Sample records for particles alpha particles

  1. Alpha Particle

    Microsoft Academic Search

    P. Murdin

    2000-01-01

    Term that is sometimes used to describe a helium nucleus, a positively charged particle that consists of two protons and two neutrons, bound together. Alpha particles, which were discovered by Ernest Rutherford (1871-1937) in 1898, are emitted by atomic nuclei that are undergoing alpha radioactivity. During this process, an unstable heavy nucleus spontaneously emits an alpha particle and transmut...

  2. Imaging alpha particle detector

    DOEpatents

    Anderson, D.F.

    1980-10-29

    A method and apparatus for detecting and imaging alpha particles sources is described. A dielectric coated high voltage electrode and a tungsten wire grid constitute a diode configuration discharge generator for electrons dislodged from atoms or molecules located in between these electrodes when struck by alpha particles from a source to be quantitatively or qualitatively analyzed. A thin polyester film window allows the alpha particles to pass into the gas enclosure and the combination of the glass electrode, grid and window is light transparent such that the details of the source which is imaged with high resolution and sensitivity by the sparks produced can be observed visually as well. The source can be viewed directly, electronically counted or integrated over time using photographic methods. A significant increase in sensitivity over other alpha particle detectors is observed, and the device has very low sensitivity to gamma or beta emissions which might otherwise appear as noise on the alpha particle signal.

  3. Summary of Alpha Particle Transport

    SciTech Connect

    Medley, S.S.; White, R.B.; Zweben, S.J.

    1998-08-19

    This paper summarizes the talks on alpha particle transport which were presented at the 5th International Atomic Energy Agency's Technical Committee Meeting on "Alpha Particles in Fusion Research" held at the Joint European Torus, England in September 1997.

  4. Alpha-particle spectrometer experiment

    NASA Technical Reports Server (NTRS)

    Gorenstein, P.; Bjorkholm, P.

    1972-01-01

    Mapping the radon emanation of the moon was studied to find potential areas of high activity by detection of radon isotopes and their daughter products. It was felt that based on observation of regions overflown by Apollo spacecraft and within the field of view of the alpha-particle spectrometer, a radon map could be constructed, identifying and locating lunar areas of outgassing. The basic theory of radon migration from natural concentrations of uranium and thorium is discussed in terms of radon decay and the production of alpha particles. The preliminary analysis of the results indicates no significant alpha emission.

  5. cap alpha. Particle confinement in compact tori

    Microsoft Academic Search

    Bozhokin

    1986-01-01

    The motion of high-energy ..cap alpha.. particles in compact tori is studied. The classically accessible regions of motion of charged particles are found. The conditions are formulated under which the ..cap alpha.. particles produced in fusion reactions are absolutely confined. An ..cap alpha.. particle starting in a region enclosed by a ''critical'' surface will never, in the course of its

  6. cap alpha. -Particle confinement in compact tori

    SciTech Connect

    Bozhokin, S.V.

    1986-11-01

    The motion of high-energy ..cap alpha.. particles in compact tori is studied. The classically accessible regions of motion of charged particles are found. The conditions are formulated under which the ..cap alpha.. particles produced in fusion reactions are absolutely confined. An ..cap alpha.. particle starting in a region enclosed by a ''critical'' surface will never, in the course of its motion, intersect the separatrix of a compact torus. These critical surfaces are constructed. The ratio of the volume of absolute ..cap alpha.. confinement to the total volume of a compact torus is calculated as a function of the magnetic field strength and the dimensions of the compact torus.

  7. Radioimmunotherapy with alpha-particle emitting radionuclides.

    PubMed

    Zalutsky, M R; Pozzi, O R

    2004-12-01

    An important consideration in the development of effective strategies for radioimmunotherapy is the nature of the radiation emitted by the radionuclide. Radionuclides decaying by the emission of alpha-particles offer the possibility of matching the cell specific reactivity of monoclonal antibodies with radiation with a range of only a few cell diameters. Furthermore, alpha-particles have important biological advantages compared with external beam radiation and beta-particles including a higher biological effectiveness, which is nearly independent of oxygen concentration, dose rate and cell cycle position. In this review, the clinical settings most likely to benefit from alpha-particle radioimmunotherapy will be discussed. The current status of preclinical and clinical research with antibodies labeled with 3 promising alpha-particle emitting radionuclides - (213)Bi, (225)Ac, and (211)At - also will be summarized. PMID:15640792

  8. Calculations of Alpha-Particle Trajectories for Long-Range Alpha Particles Emitted in Spontaneous Fission

    Microsoft Academic Search

    Y. Boneh; Z. Fraenkel; I. Nebenzahl

    1967-01-01

    Calculated angular and energy distributions of the alpha particles in long-range alpha-particle fission are presented. The distributions were obtained from calculated alpha-particle trajectories based on a three-point-charge model for the scissioning nucleus. The calculation is two dimensional, and spontaneous fission (no preferred direction) is assumed. This reduces the number of free variables of the system to seven (except for the

  9. The status of alpha-particle diagnostics

    SciTech Connect

    Young, K.M.; Johnson, D.W.

    1992-08-01

    There is a flurry of activity to complete alpha-particle diagnostics so that they can undergo some experimental testing in DT plasmas on JET or TFTR prior to implementation on ITER. Successful measurements of escaping charged fusion products have been made in DD plasmas, and the {alpha}-particle source can be well characterized by neutron profile measurement. These methods can be extrapolated to DT plasmas. Measurement of the confined {alpha}-particles requires a new technique. Collective Thomson scattering, methods involving charge-exchange interactions and nuclear reactions with impurities will be discussed. Some assessment is given of the capabilities of these techniques, bearing in mind the potential for their use in the physics phase of the ITER program.

  10. The status of alpha-particle diagnostics

    SciTech Connect

    Young, K.M.; Johnson, D.W.

    1992-01-01

    There is a flurry of activity to complete alpha-particle diagnostics so that they can undergo some experimental testing in DT plasmas on JET or TFTR prior to implementation on ITER. Successful measurements of escaping charged fusion products have been made in DD plasmas, and the {alpha}-particle source can be well characterized by neutron profile measurement. These methods can be extrapolated to DT plasmas. Measurement of the confined {alpha}-particles requires a new technique. Collective Thomson scattering, methods involving charge-exchange interactions and nuclear reactions with impurities will be discussed. Some assessment is given of the capabilities of these techniques, bearing in mind the potential for their use in the physics phase of the ITER program.

  11. Alternating current long range alpha particle detector

    DOEpatents

    MacArthur, D.W.; McAtee, J.L.

    1993-02-16

    An alpha particle detector, utilizing alternating currents, which is capable of detecting alpha particles from distinct sources. The use of alternating currents allows use of simpler ac circuits which, in turn, are not susceptible to dc error components. It also allows the benefit of gas gain, if desired. In the invention, a voltage source creates an electric field between two conductive grids, and between the grids and a conductive enclosure. Air containing air ions created by collision with alpha particles is drawn into the enclosure and detected. In some embodiments, the air flow into the enclosure is interrupted, creating an alternating flow of ions. In another embodiment, a modulated voltage is applied to the grid, also modulating the detection of ions.

  12. Alternating current long range alpha particle detector

    DOEpatents

    MacArthur, Duncan W. (Los Alamos, NM); McAtee, James L. (Los Alamos, NM)

    1993-01-01

    An alpha particle detector, utilizing alternating currents, whcih is capable of detecting alpha particles from distinct sources. The use of alternating currents allows use of simpler ac circuits which, in turn, are not susceptible to dc error components. It also allows the benefit of gas gain, if desired. In the invention, a voltage source creates an electric field between two conductive grids, and between the grids and a conductive enclosure. Air containing air ions created by collision with alpha particles is drawn into the enclosure and detected. In some embodiments, the air flow into the enclosure is interrupted, creating an alternating flow of ions. In another embodiment, a modulated voltage is applied to the grid, also modulating the detection of ions.

  13. Patient-specific alpha-particle dosimetry.

    PubMed

    Palm, Stig; Elgqvist, Jörgen; Jacobsson, Lars

    2011-10-01

    Alpha-particle therapy has received increased attention during the last few years because of the development of new targeting constructs and new labeling techniques and the availability of suitable ?-particle - emitting radionuclides. This work provides an overview of methods that have been used in clinical trials in estimating the absorbed dose to tumors and healthy tissue in patients following such ?-particle therapy. Similarities and differences compared to conventional therapies using ?¯-particle emitters are presented. The specific challenges of establishing accurate dosimetry for ?- particles in the individual patient are also discussed, as is the effect that improved patient-specific dosimetry might have on the overall efficacy of this type of therapy. PMID:22202155

  14. Nuclear diagnostic for fast alpha particles

    DOEpatents

    Grisham, Larry R. (Lawrence Township, Mercer County, NJ); Post, Jr., Douglass E. (Belle Mead, NJ); Dawson, John M. (Pacific Palisades, CA)

    1986-01-01

    Measurement of the velocity distribution of confined energetic alpha particles resulting from deuterium-tritium fusion reactions in a magnetically contained plasma is provided. The fusion plasma is seeded with energetic boron neutrals for producing, by means of the reaction .sup.10 B (.alpha.,n) .sup.13 N reaction, radioactive nitrogen nuclei which are then collected by a probe. The radioactivity of the probe is then measured by conventional techniques in determining the energy distribution of the alpha particles in the plasma. In a preferred embodiment, diborane gas (B.sub.2 H.sub.6) is the source of the boron neutrals to produce .sup.13 N which decays almost exclusively by positron emission with a convenient half-life of 10 minutes.

  15. Gallium Nitride Room Temperature alpha Particle Detectors

    Microsoft Academic Search

    Min Lu; Guo-Guang Zhang; Kai Fu; Guo-Hao Yu

    2010-01-01

    Gallium Nitride (GaN) room temperature alpha particle detectors are fabricated and characterized, whose device structure is Schottky diode. The current-voltage (I - V) measurements reveal that the reverse breakdown voltage of the detectors is more than 200 V owing to the consummate fabrication processes, and that the Schottky barrier and ideal factor of the detectors are 0.64 eV and 1.02,

  16. Alpha-particle-induced soft errors in dynamic memories

    Microsoft Academic Search

    T. C. May; M. H. Woods

    1979-01-01

    A new physical soft error mechanism in dynamic RAM's and CCD's is the upset of stored data by the passage of alpha particles through the memory array area. The alpha particles are emitted by the radioactive decay of uranium and thorium which are present in parts-per-million levels in packaging materials. When an alpha particle penetrates the die surface, it can

  17. ALPHA-PARTICLE RADIOBIOLOGICAL EXPERIMENTS USING THIN CR-39 DETECTORS

    E-print Network

    Yu, K.N.

    ALPHA-PARTICLE RADIOBIOLOGICAL EXPERIMENTS USING THIN CR-39 DETECTORS K. F. Chan1 , S. Y. M. Siu2 advantages of using CR-39 detectors as the cell-culture substrates in alpha-particle radiobiological the DNA damage in individual HeLa cervix cancer cells after alpha-particle irradiation. We prepared thin

  18. Alpha particle analysis using PEARLS spectrometry

    SciTech Connect

    McKlveen, J.W.; Klingler, G.W.; McDowell, W.J.; Case, G.N.

    1984-01-01

    Alpha particle assay by conventional plate-counting methods is difficult because chemical separation, tracer techniques, and/or self-absorption losses in the final sample may cause either non-reproducible results or create unacceptable errors. PEARLS (Photon-Electron Rejecting Alpha Liquid Scintillation) Spectrometry is an attractive alternative since radionuclides may be extracted into a scintillator in which there would be no self-absorption or geometry problems and in which up to 100% chemical recovery and counting efficiency is possible. Sample preparation may include extraction of the alpha emitter of interest by a specific organic-phase-soluble compound directly into the liquid scintillator. Detection electronics use energy and pulse-shape discrimination to provide discrete alpha spectra and virtual absence of beta and gamma backgrounds. Backgrounds on the order of 0.01 cpm are readily achievable. Accuracy and reproducibility are typically in the 100 +-1% range. Specific procedures have been developed for gross alpha, uranium, plutonium, thorium, and polonium assay. This paper will review liquid scintillation alpha counting methods and reference some of the specific applications. 8 refs., 1 fig.

  19. Measurement of Alpha Particle Radioactivtiy in IC Device Packages

    Microsoft Academic Search

    E. S. Meieran; P. R. Engel; T. C. May

    1979-01-01

    Alpha particle radioactivity in package materials has been shown to cause soft errors in semiconductor devices. The particles are emitted by uranium and thorium decay sequence radioactive isotopes present as trace impurities in the raw materials used to make the package component parts. Chemical and radiation analys s techniques were correlated to alpha particle fluxes, which range in value from

  20. Targeted alpha particle immunotherapy for myeloid leukemia.

    PubMed

    Jurcic, Joseph G; Larson, Steven M; Sgouros, George; McDevitt, Michael R; Finn, Ronald D; Divgi, Chaitanya R; Ballangrud, Ase M; Hamacher, Klaus A; Ma, Dangshe; Humm, John L; Brechbiel, Martin W; Molinet, Roger; Scheinberg, David A

    2002-08-15

    Unlike beta particle-emitting isotopes, alpha emitters can selectively kill individual cancer cells with a single atomic decay. HuM195, a humanized anti-CD33 monoclonal antibody, specifically targets myeloid leukemia cells and has activity against minimal disease. When labeled with the beta-emitters (131)I and (90)Y, HuM195 can eliminate large leukemic burdens in patients, but it produces prolonged myelosuppression requiring hematopoietic stem cell transplantation at high doses. To enhance the potency of native HuM195 yet avoid the nonspecific cytotoxicity of beta-emitting constructs, the alpha-emitting isotope (213)Bi was conjugated to HuM195. Eighteen patients with relapsed and refractory acute myelogenous leukemia or chronic myelomonocytic leukemia were treated with 10.36 to 37.0 MBq/kg (213)Bi-HuM195. No significant extramedullary toxicity was seen. All 17 evaluable patients developed myelosuppression, with a median time to recovery of 22 days. Nearly all the (213)Bi-HuM195 rapidly localized to and was retained in areas of leukemic involvement, including the bone marrow, liver, and spleen. Absorbed dose ratios between these sites and the whole body were 1000-fold greater than those seen with beta-emitting constructs in this antigen system and patient population. Fourteen (93%) of 15 evaluable patients had reductions in circulating blasts, and 14 (78%) of 18 patients had reductions in the percentage of bone marrow blasts. This study demonstrates the safety, feasibility, and antileukemic effects of (213)Bi-HuM195, and it is the first proof-of-concept for systemic targeted alpha particle immunotherapy in humans. PMID:12149203

  1. Epithermal and thermal alpha-particle transport and control

    SciTech Connect

    Miley, G.H.; Hu, S.C.; Varadarajan, V. (Illinois Univ., Urbana, IL (United States))

    1990-12-01

    In this paper alpha-particle ash accumulation in tokamaks and two possible ash control techniques are discussed. The effect of thermal alpha-particle ash accumulation on plasma performance is examined using a zero-dimensional analysis with profile corrections. Alpha-particle accumulation is shown to have serious effects on ignition requirements. An analytical model developed to predict the effect of sawtooth disruption on ash accumulation is discussed. The analytical results indicate that the sawtooth is effective when the temperature profile is parabolic or flatter. Alpha-particle ejection by a fishbone oscillation is envisaged to be helpful in ash control, and a model of the physics in a large-aspect-ratio approximation is discussed using an extended version of a Chen et al. formalism. The trapped particle destabilization of the internal kinks due to the alpha particles and a second hot-particle species is considered, and the expected oscillation frequency and growth rates are derived.

  2. Alpha particle effects on the internal kink and fishbone modes

    SciTech Connect

    Wu, Y.; Cheng, C.Z.; White, R.B. (Plasma Physics Laboratory, Princeton University, Princeton, New Jersey 08540 (United States))

    1994-10-01

    The effects of alpha particles on the internal kink and fishbone modes are studied analytically. The nonadiabatic contribution from untrapped alpha particles is negligible. Finite inverse aspect ratio, plasma [beta], and plasma shaping effects can significantly enhance the trapped particle drift reversal domain in the pitch angle space and reduce the bounce-averaged magnetic drift frequency. The decrease of the drift magnitude and drift reversal effects on the ideal kink mode is small, but the [beta][sub [alpha

  3. Alpha particle loss in the TFTR DT experiments

    SciTech Connect

    Zweben, S.J.; Darrow, D.S.; Herrmann, H.W. [and others

    1995-01-01

    Alpha particle loss was measured during the TFTR DT experiments using a scintillator detector located at the vessel bottom in the ion grad-B drift direction. The DT alpha particle loss to this detector was consistent with the calculated first-orbit loss over the whole range of plasma current I=0.6-2.7 MA. In particular, the alpha particle loss rate per DT neutron did not increase significantly with fusion power up to 10.7 MW, indicating the absence of any new ``collective`` alpha particle loss processes in these experiments.

  4. Analysis of radiation risk from alpha particle component of soalr particle events

    NASA Technical Reports Server (NTRS)

    Cucinotta, F. A.; Townsend, L. W.; Wilson, J. W.; Golightly, M. J.; Weyland, M.

    1994-01-01

    The Solar Particle Events (SPE) will contain a primary alpha particle component, representing a possible increase in the potential risk to astronauts during an SPE over the often studied proton component. We discuss the physical interactions of alpha particles important in describing the transport of these particles through spacecraft and body shielding. Models of light ion reactions are presented and their effects on energy and Linear Energy Transfer (LET) spectra in shielding are discussed. We present predictions of particle spectra, dose, and dose equivalent in organs of interest for SPE spectra typical of those occurring in recent solar cycles. The large events of solar cycle 19 are found to have substantial increase in biological risk from alpha particles, including a large increase in secondary neutron production from alpha particle breakup.

  5. Alpha-Particle Condensation in Nuclear Systems

    NASA Astrophysics Data System (ADS)

    Schuck, P.; Funaki, Y.; Horiuchi, H.; Röpke, G.; Tohsaki, A.; Yamada, T.

    2013-02-01

    The onset of quartetting, i.e. ?-particle condensation, in symmetric and asymmetric nuclear matter is studied with the help of an in-medium modified four nucleon equation. It is found that at very low density quartetting wins over pairing, because of the strong binding of the ?-particles. The critical temperature can reach values up to around 8 MeV. The disappearance of ?-particles with increasing density, i.e. the Mott transition, is investigated. In finite nuclei the Hoyle state, that is the 02+ of 12C is identified as an '?-particle condensate' state. It is conjectured that such states also exist in heavier n?-nuclei, like 16O, 20Ne, etc. The sixth 0+ state in 16O is proposed as an analogue to the Hoyle state. The Gross-Pitaevski equation is employed to make an estimate of the maximum number of ? particles a condensate state can contain. Possible quartet condensation in other systems is discussed briefly.

  6. Analytic expressions for {alpha} particle preformation in heavy nuclei

    SciTech Connect

    Zhang, H. F.; Wang, Y. J.; Dong, J. M. [School of Nuclear Science and Technology, Lanzhou University, Lanzhou 730000 (China); Royer, G. [Laboratoire Subatech, UMR IN2P3/CNRS Universite Ecole des Mines, Nantes 44 (France); Zuo, W.; Li, J. Q. [School of Nuclear Science and Technology, Lanzhou University, Lanzhou 730000 (China); Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000 (China)

    2009-11-15

    Experimental {alpha} decay energies and half-lives are investigated systematically to extract {alpha} particle preformation in heavy nuclei. Formulas for the preformation factors are proposed that can be used to guide microscopic studies on preformation factors and perform accurate calculations of the {alpha} decay half-lives. There is little evidence for the existence of an island of long stability of superheavy nuclei.

  7. Alpha particle effects on the internal kink and fishbone modes

    SciTech Connect

    Wu, Y.; Cheng, C.Z.; White, R.B.

    1994-06-01

    The effects of alpha particles on the internal kink and fishbone modes are studied analytically. The nonadiabatic contribution from untrapped alpha particles is negligible. Finite inverse aspect ratio, plasma {beta} and plasma shaping effects can significantly enhance the trapped particle drift reversal domain in the pitch angle space and reduce the bounce-averaged magnetic drift frequency. The drift reversal effect on the ideal kink mode is small, but the {beta}{sub {alpha}} threshold for the fishbone mode can be much lower than previously predicted. Moreover, the fishbone mode could be excited by alpha particles even when the plasma is stable in the ideal MHD limit. In addition, the ion diamagnetic drift frequency (finite ion Larmor radius effect) has a strong destabilizing effect on the fishbone mode when it is comparable with the trapped alpha averaged precessional drift frequency, even though it stabilizes the plasma in the ideal MHD limit.

  8. Effect of alpha particles on Toroidal Alfven Eigenmodes

    SciTech Connect

    Berk, H.L.

    1992-11-01

    An overview is given of the analytic structure for the linear theory of the Toroidal Alfven Eigenmode (TAE), where multiple gap structures occur. A discussion is given of the alpha particle drive and the various dissipation mechanisms that can stabilize the system. A self-consistent calculation of the TAE mode, for a low-beta high-aspect-ratio plasma, indicates that though the alpha particle drive is comparable to the dissipation mechanisms, overall stability is still achieved for ignited ITER-like plasma. A brief discussion is given of the nonlinear theory for the TAE mode and how nonlinear alpha particle dynamics can be treated by mapping methods.

  9. ITER alpha particle diagnostics using knock-on ion tails

    SciTech Connect

    Fisher, R.K.; Parks, P.B.; McChesney, J.M. [and others

    1995-09-01

    Alpha particles will play a critical role in the physics and successful operation of ITER. Achieving fusion ignition requires that the {alpha} particles created by deuterium-tritium (D-T) reactions deposit a large fraction of their energy in the reacting plasma before they are lost. Toroidal field ripple can localize any alpha particle losses and cause first wall damage. We have proposed a new method of measuring the fast confined {alpha}-particle distribution in a reacting plasma. The same elastic collisions that transfer the alpha energy to the D-T plasma ions and allow fusion ignition will also create a high energy tail on the deuterium and tritium ion energy distributions. Some of these energetic tail ions will undergo fusion reactions with the background plasma producing neutrons whose energy is increased significantly above 14 MeV due to the kinetic energy of the reacting ions. Measurement of this high energy tail on the D-T neutron distribution as a function of plasma minor radius would provide information on the alpha density profile with a time response equal to the ion slowing-down time. Although this technique may provide only limited information on the {alpha}-particle energy distribution, experimental studies of fast ions on existing tokamaks have shown that the observed slowing-down is essentially classical. Hence the {alpha}-energy distribution is expected to be classical except in situations where the {alpha}-confinement is poor. The confinement of {alpha}`s can be affected by ripple losses and a number of instabilities. Toroidal field ripple can cause both prompt orbit losses and stochastic ripple diffusion losses. Magnetohydrodynamic activity, including fishbone instabilities, toroidal Alfven eigenmodes, and sawtooth oscillations, may also affect alpha confinement. The diagnostic proposed here, by monitoring the confined alpha population, can provide valuable information on the confinement of fast alphas in a reacting plasma.

  10. Dosimetry and radiobiological studies of automated alpha-particle irradiator.

    PubMed

    M V, Jyothish Babu; Shinde, Sanjay G; S, Sunil Kumar; Ali, Manjoor; Vasumathy, R; Kumar, Amit; Kolekar, R; Kumar, Manish; Nema, P; Bhagwat, P V; Pandey, Badri N

    2013-01-01

    Understanding the effect of alpha radiation on biological systems is an important component of radiation risk assessment and associated health consequences. However, due to the short path length of alpha radiation in the atmosphere, in vitro radiobiological experiments cannot be performed with accuracy in terms of dose and specified exposure time. The present paper describes the design and dosimetry of an automated alpha-particle irradiator named 'BARC BioAlpha', which is suitable for in vitro radiobiological studies. Compared to alpha irradiators developed in other laboratories, BARC BioAlpha has integrated computer-controlled movement of the alpha-particle source, collimator, and electronic shutter. The diaphragm blades of the electronic shutter can control the area (diameter) of irradiation without any additional shielding, which is suitable for radiobiological bystander studies. To avoid irradiation with incorrect parameters, a software interlock is provided to prevent shutter opening, unless the user-specified speed of the source and collimator are achieved. The dosimetry of the alpha irradiator using CR-39 and silicon surface barrier detectors showed that ~4 MeV energy of the alpha particle reached the cells on the irradiation dish. The alpha irradiation was also demonstrated by the evaluation of DNA double-strand breaks in human cells. In conclusion, 'BARC BioAlpha' provides a user-friendly alpha irradiation system for radiobiological experiments with a novel automation mechanism for better accuracy of dose and exposure time. PMID:24266413

  11. Full orbit calculation for lost alpha particle measurement on ITERa)

    NASA Astrophysics Data System (ADS)

    Funaki, D.; Isobe, M.; Nishiura, M.; Sato, Y.; Okamoto, A.; Kobuchi, T.; Kitajima, S.; Sasao, M.

    2008-10-01

    An orbit following calculation code with full gyromotion under the ITER magnetic field configuration has been developed to investigate escaping alpha particle orbits in ITER and to determine the geometrical arrangement for alpha particle detection. The code contained the full geometrical information of the first wall panels. It was carefully investigated whether an alpha particle escaping from the plasma through the last closed flux surface does not touch or intersect the first wall boundary before reaching the detection point. Candidates of blanket module modification have been studied to achieve effective measurement geometry for escaping alpha particle detection. The calculations showed that direct orbit loss and banana diffusion can be detected with a probe head recessed from the first wall surface.

  12. Evaluation of silicon active pixel sensors for alpha particle detection

    NASA Astrophysics Data System (ADS)

    Maneuski, Dzmitry; Blue, Andrew; Hynds, Daniel; Mac Raighne, Aaron; O'Shea, Val

    2011-12-01

    Alpha particles can be used as a test stimulus offering several advantages for probing materials of micrometre thicknesses. In this work a silicon CMOS Active Pixel Sensor (APS) is evaluated for alpha particle detection and imaging. These devices can replace traditionally used solid-state track detectors, giving advantages of increased sensitivity, improved linearity and higher dynamic range. CMOS APSs offer high detection efficiency, low noise and digital readout. Qualitative and quantitative analysis of the back-illuminated back-thinned (BT) and standard sensor response to 5.5 MeV alpha particles is presented. Alpha particle detection efficiency was estimated and energy resolution was measured. Imaging capabilities were assessed and quantified. Cluster centroiding algorithms were implemented for image quality improvement.

  13. Full orbit calculation for lost alpha particle measurement on ITER

    SciTech Connect

    Funaki, D.; Isobe, M.; Nishiura, M.; Sato, Y.; Okamoto, A.; Kobuchi, T.; Kitajima, S.; Sasao, M. [Department of Quantum Energy Science, Tohoku University, Sendai 980-8579 (Japan)

    2008-10-15

    An orbit following calculation code with full gyromotion under the ITER magnetic field configuration has been developed to investigate escaping alpha particle orbits in ITER and to determine the geometrical arrangement for alpha particle detection. The code contained the full geometrical information of the first wall panels. It was carefully investigated whether an alpha particle escaping from the plasma through the last closed flux surface does not touch or intersect the first wall boundary before reaching the detection point. Candidates of blanket module modification have been studied to achieve effective measurement geometry for escaping alpha particle detection. The calculations showed that direct orbit loss and banana diffusion can be detected with a probe head recessed from the first wall surface.

  14. Q Values in alpha-Particle-Accompanied Ternary Fission

    Microsoft Academic Search

    N. Feather

    1968-01-01

    In relation to any mode of binary fission, there are nine possible ways in which the constituents of an alpha particle can be assembled using nucleons from one or both of the nascent binary fragments. Basing a definition of \\

  15. Alpha particle radiography with the CR39 nuclear track detector

    Microsoft Academic Search

    B. A. de Souza; S. C. Cabral; R. T. Lopes

    1995-01-01

    This work studies the alpha particle radiography technique, in conjunction with the CR-39 plastic track detector. The irradiations were made in the CV-28 cyclotron at IEN\\/CNEN\\/RJ, using a 7 MeV\\/nucleon alpha particle beam. All etches were performed by using a 6.25 N NaOH solution, at 70°C. The best etch time to obtain radiographs was determined. A calibration curve (Gray Levels

  16. Alpha particle effects on the internal kink modes

    SciTech Connect

    Wu, Yanlin; Cheng, C.Z.

    1994-08-01

    The {alpha}-particle effects on the internal kink mode stability are studied. Finite Grad-Shafranov Shift, plasma {beta}, and plasma shape can significantly enhance the trapped particle drift reversal domain in pitch angle space and reduce average magnetic drift frequency. The drift reversal effect on the ideal kink mode is small, but the {beta}{sub {alpha}} threshold for the fishbone mode can be much lower than previously predicted. In addition, the ion diamagnetic drift has a stronger destabilizing effect.

  17. Shielding of manned space vehicles against protons and alpha particles

    NASA Technical Reports Server (NTRS)

    Alsmiller, R. G., Jr.; Santoro, R. T.; Barish, J.; Claiborne, H. C.

    1972-01-01

    The available information on the shielding of manned space vehicles against protons and alpha particles is summarized. The emphasis is placed on shielding against Van Allen belt protons and against solar-flare protons and alpha particles, but information on shielding against galactic cosmic rays is also presented. The approximation methods for use by nonexperts in the space shielding field are those that are standard in the space shielding literature.

  18. Alpha particle backscattering measurements used for chemical analysis of surfaces

    NASA Technical Reports Server (NTRS)

    Patterson, J. H.

    1967-01-01

    Alpha particle backscattering performs a chemical analysis of surfaces. The apparatus uses a curium source and a semiconductor detector to determine the energy spectrum of the particles. This in turn determines the chemical composition of the surface after calibration to known samples.

  19. Alpha particle losses from Tokamak Fusion Test Reactor deuteriumtritium plasmas*

    E-print Network

    Alpha particle losses from Tokamak Fusion Test Reactor deuterium­tritium plasmas* D. S. Darrow, S. Petrov,e) C. K. Phillips, M. H. Redi, E. Ruskov,d) D. A. Spong,b) E. J. Strait,c) G. Taylor, R. B. White have a significant influence on tokamak reactor viability, the loss of deuterium­tritium alpha

  20. Measurement of alpha particle energy using windowless electret ion chambers.

    PubMed

    Dua, S K; Kotrappa, P; Srivastava, R; Ebadian, M A; Stieff, L R

    2002-10-01

    Electret ion chambers are inexpensive, lightweight, robust, commercially available, passive, charge-integrating devices for accurate measurement of different ionizing radiations. In an earlier work a chamber of dimensions larger than the range of alpha particles having aluminized Mylar windows of different thickness was used for measurement of alpha radiation. Correlation between electret mid-point voltage, alpha particle energy, and response was developed and it was shown that this chamber could be used for estimating the effective energy of an unknown alpha source. In the present study, the electret ion chamber is used in the windowless mode so that the alpha particles dissipate their entire energy inside the volume, and the alpha particle energy is determined from the first principles. This requires that alpha disintegration rate be accurately known or measured by an alternate method. The measured energies were within 1 to 4% of the true values for different sources (230Th, 237Np, 239Pu, 241Am, and 224Cm). This method finds application in quantitative determination of alpha energy absorbed in thin membrane and, hence, the absorbed dose. PMID:12240732

  1. Actinium-225 in targeted alpha-particle therapeutic applications.

    PubMed

    Scheinberg, David A; McDevitt, Michael R

    2011-10-01

    Alpha particle-emitting isotopes are being investigated in radioimmunotherapeutic applications because of their unparalleled cytotoxicity when targeted to cancer and their relative lack of toxicity towards untargeted normal tissue. Actinium- 225 has been developed into potent targeting drug constructs and is in clinical use against acute myelogenous leukemia. The key properties of the alpha particles generated by 225Ac are the following: i) limited range in tissue of a few cell diameters; ii) high linear energy transfer leading to dense radiation damage along each alpha track; iii) a 10 day halflife; and iv) four net alpha particles emitted per decay. Targeting 225Ac-drug constructs have potential in the treatment of cancer. PMID:22202153

  2. Targeted alpha-particle immunotherapy for acute myeloid leukemia.

    PubMed

    Jurcic, Joseph G; Rosenblat, Todd L

    2014-01-01

    Because alpha-particles have a shorter range and a higher linear energy transfer (LET) compared with beta-particles, targeted alpha-particle immunotherapy offers the potential for more efficient tumor cell killing while sparing surrounding normal cells. To date, clinical studies of alpha-particle immunotherapy for acute myeloid leukemia (AML) have focused on the myeloid cell surface antigen CD33 as a target using the humanized monoclonal antibody lintuzumab. An initial phase I study demonstrated the safety, feasibility, and antileukemic effects of bismuth-213 ((213)Bi)-labeled lintuzumab. In a subsequent study, (213)Bi-lintuzumab produced remissions in some patients with AML after partial cytoreduction with cytarabine, suggesting the utility of targeted alpha-particle therapy for small-volume disease. The widespread use of (213)Bi, however, is limited by its short half-life. Therefore, a second-generation construct containing actinium-225 ((225)Ac), a radiometal that generates four alpha-particle emissions, was developed. A phase I trial demonstrated that (225)Ac-lintuzumab is safe at doses of 3 ?Ci/kg or less and has antileukemic activity across all dose levels studied. Fractionated-dose (225)Ac-lintuzumab in combination with low-dose cytarabine (LDAC) is now under investigation for the management of older patients with untreated AML in a multicenter trial. Preclinical studies using (213)Bi- and astatine-211 ((211)At)-labeled anti-CD45 antibodies have shown that alpha-particle immunotherapy may be useful as part conditioning before hematopoietic cell transplantation. The use of novel pretargeting strategies may further improve target-to-normal organ dose ratios. PMID:24857092

  3. Utility of extracting {alpha}-particle energy by waves

    SciTech Connect

    Fisch, N.J.; Herrmann, M.C.

    1994-05-01

    The utility of extracting {alpha}-particle power, and then diverting this power to fast fuel ions, is investigated. As power is diverted to fast ions and then to ions, a number of effects come into play, as the relative amounts of pressure taken up by electrons, fuel ions, and fast {alpha}-particles shift. In addition, if the {alpha}-particle power is diverted to fast fuel ions, there is an enhanced fusion reactivity because of the nonthermal component of the ion distribution. Some useful expressions for describing these effects are derived, and it is shown that fusion reactors with power density about twice what otherwise might be obtained can be contemplated, so long as a substantial amount of the {alpha}-particle power can be diverted. Interestingly, in this mode of operation, once the electron heat is sufficiently confined, further improvement in confinement is actually not desirable. A similar improvement in fusion power density can be obtained for advanced fuel mixtures such as D-He{sup 3}, where the power of both the energetic {alpha}-particles and the energetic protons might be diverted advantageously.

  4. Mutagenic effects of alpha particles in normal human skin fibroblasts

    SciTech Connect

    Chen, D.J.; Carpenter, S.; Hanks, T. [Los Alamos National Lab., NM (United States)

    1992-12-31

    Alpha-irradiation to the bronchial airways from inhaled radon progeny increases the risk of developing lung cancer. The molecular mechanism of radon-induced lung cancer is not clear, but one of the most important genetic effects of ionizing radiation is the induction of gene mutation. Mutations, especially those associated with visible chromosome abnormalities in humans, have been associated with cancer. Therefore, our objective is to use a well-defined model system to determine the mutagenic potential of alpha particles in normal human skin cells and to define this action at the molecular level. Normal human skin fibroblasts were irradiated with alpha particles (3.59 MeV, LET 115 keV {mu}m{sup {minus}1}) emitted from the decay of {sup 238}Pu. Mutagenicity was determined at the X-linked hypoxanthine guanine phosphoribosyl transferase (HPRT) locus. Results from this study indicate that beta particles were more efficient in mutation induction than gamma rays. Based on the initial slopes of the dose-response curves, the RBE for mutation is about 8 for alpha particles. HPRT-deficient mutants which are resistant to 6-thioguanine have been isolated and analyzed by the Southern blot technique. To date, we have characterized 69 gamma-ray-induced and 195 alpha-particle-induced HPRT-deficient mutants. Our data indicate that more than 50% of all gamma-ray-induced mutants have band patterns identical to that observed for the normal structural HPRT gene, whereas the remaining mutants (45%) contain either a rearrangement, partial deletion, or total deletion of the HPRT gene. In contrast, only 30% of alpha-particle-induced human HPRT mutants contain a normal Southern blot pattern, and about 50% indicate total deletion of the HPRT gene. Our results support the notion that high-LET radiation produces more unrepaired or misrepaired DNA damage than do gamma rays.

  5. Validating modeling assumptions of alpha particles in electrostatic turbulence

    NASA Astrophysics Data System (ADS)

    Wilkie, G. J.; Abel, I. G.; Highcock, E. G.; Dorland, W.

    2015-06-01

    To rigorously model fast ions in fusion plasmas, a non-Maxwellian equilibrium distribution must be used. In this work, the response of high-energy alpha particles to electrostatic turbulence has been analyzed for several different tokamak parameters. Our results are consistent with known scalings and experimental evidence that alpha particles are generally well confined: on the order of several seconds. It is also confirmed that the effect of alphas on the turbulence is negligible at realistically low concentrations, consistent with linear theory. It is demonstrated that the usual practice of using a high-temperature Maxwellian, while previously shown to give an adequate order-of-magnitude estimate of the diffusion coefficient, gives incorrect estimates for the radial alpha particle flux, and a method of correcting it in general is provided. Furthermore, we see that the timescales associated with collisions and transport compete at moderate energies, calling into question the assumption that alpha particles remain confined to a flux surface that is used in the derivation of the slowing-down distribution.

  6. Optical appearance of alpha particle tracks in CR39 SSNTD

    Microsoft Academic Search

    K. N. Yu; H. H. W. Lee; A. W. T. Wong; Y. L. Law; S. F. L. Cheung; D. Nikezic; F. M. F. Ng

    2007-01-01

    A ray tracing method based on geometrical optics was used to study the tracks from alpha particles with different energies and with an incident angle of 50°. The transmission operation mode of the microscope is simulated. Considering the distribution of light intensities from the tracks, the mean and the 80% percentile gray levels from real experiments are proposed as quantitative

  7. Modelling and Dosimetry for Alpha-Particle Therapy

    PubMed Central

    Sgouros, George; Hobbs, Robert F.; Song, Hong

    2015-01-01

    As a consequence of the high potency and short range of alpha-particles, radiopharmaceutical therapy with alpha-particle emitting radionuclides is a promising treatment approach that is under active pre-clinical and clinical investigation. To understand and predict the biological effects of alpha-particle radiopharmaceuticals, dosimetry is required at the micro or multi-cellular scale level. At such a scale, highly non-uniform irradiation of the target volume may be expected and the utility of a single absorbed dose value to predict biological effects comes into question. It is not currently possible to measure the pharmacokinetic input required for micro scale dosimetry in humans. Accordingly, pre-clinical studies are required to provide the pharmacokinetic data for dosimetry calculations. The translation of animal data to the human requires a pharmacokinetic model that links macro- and micro-scale pharmacokinetics thereby enabling the extrapolation of micro-scale kinetics from macroscopic measurements. These considerations along with a discussion of the appropriate physical quantity and related units for alpha-particle radiopharmaceutical therapy are examined in this review. PMID:22201712

  8. Nuclear alpha-particle condensates or the emperor's new clothes

    E-print Network

    Zinner, N T

    2007-01-01

    We assess the validity of recent claims for appearance of alpha-cluster condensation in nuclei. We compare different measures of condensation and show that few-body nuclear condensates are ill-defined. We use the quantality condition of Mottelson, separating solid and mean-field structures, to emphasize the conflict between localization and condensate formation. We explore the connection between Ikeda diagrams, linear chains and Tonks-Girardeau gasses. We show that no new information is contained in approximations of nuclear states as alpha-cluster condensates. Condensate states of more than three alpha-particles do not exist due to couplings to other degrees of freedom.

  9. Selective flow path alpha particle detector and method of use

    DOEpatents

    Orr, Christopher Henry (Sellafield, Seascale, Cumbria, GB); Luff, Craig Janson (Sellafield, Seascale, Cumbria, GB); Dockray, Thomas (Sellafield, Seascale, Cumbria, GB); Macarthur, Duncan Whittemore (P.O. Box 1663, Los Alamos, NM 87545)

    2002-01-01

    A method and apparatus for monitoring alpha contamination are provided in which ions generated in the air surrounding the item, by the passage of alpha particles, are moved to a distant detector location. The parts of the item from which ions are withdrawn can be controlled by restricting the air flow over different portions of the apparatus. In this way, detection of internal and external surfaces separately, for instance, can be provided. The apparatus and method are particularly suited for use in undertaking alpha contamination measurements during the commissioning operations.

  10. The effects of alpha particle irradiation on stainless steel 

    E-print Network

    Shipp, John Douglas

    1999-01-01

    (1000), Pu 239, Pu 240, Am 241 +, deveta(1000), dev Jz, devflux, avgSae(1000) +, avgeta(1000), avg Jz, avgflux, stdSae(1000) +, stdeta(1000), std Jz, stdflux, particle(10), avgparticle, stdparticle, +sumparticle, Elow, Elo(10), devElo, stdElo, sum...THE EFFECTS OF ALPHA PARTICLE IRRADIATION ON STAINLESS STEEL A Thesis by JOHN DOUGLAS SHIPP Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE...

  11. Quality factors for alpha particles emitted in tissue

    NASA Technical Reports Server (NTRS)

    Borak, Thomas B.; Chatterjee, A. (Principal Investigator)

    2002-01-01

    A concept of a mean or dose averaged quality factor was defined in ICRP Publication 26 using relationships for quality factor as a function of LET. The concept of radiation weighting factors, wR, was introduced in ICRP Publication 60 in 1990. These are meant to be generalized factors that modify absorbed dose to reflect the risk of stochastic effects as a function of the quality of the radiation incident on the body or emitted by radioactivity within the body. The values of wr are equal to 20 for all alpha particles externally or internally emitted. This note compares the dose averaged quality factor for alpha particles originating in tissue using the old and revised recommendations for quality factor as a function of LET. The dose averaged quality factor never exceeds 20 using the old recommendations and is never less than 20 with the revised recommendations.

  12. GaN-based PIN alpha particle detectors

    Microsoft Academic Search

    Guo Wang; Kai Fu; Chang-sheng Yao; Dan Su; Guo-guang Zhang; Jin-yan Wang; Min Lu

    GaN-based PIN alpha particle detectors are studied in this article. The electrical properties of detectors have been investigated, such as current–voltage (I–V) and capacitance–voltage (C–V). The reverse current of all detectors is in nA range applied at 30V, which is suitable for detector operation. The charge collection efficiency (CCE) is measured to be approximately 80% but the energy resolution is

  13. A Novel Experiment to Investigate the Attenuation of Alpha Particles in Air

    ERIC Educational Resources Information Center

    Andrews, D. G. H.

    2008-01-01

    A simple student experiment investigating dependence on air pressure of the attenuation of alpha particles in air is described. An equation giving the pressure needed to absorb all alpha particles of a given energy is derived from the Bethe-Bloch formula. Results are presented for the attenuation of alpha particles from americium 241 and radium…

  14. Influence of Magnolol on the bystander effect induced by alpha-particle irradiation

    E-print Network

    Yu, K.N.

    Influence of Magnolol on the bystander effect induced by alpha-particle irradiation T.P.W. Wong, Hong Kong a r t i c l e i n f o Keywords: Bystander effect Alpha-particle CHO cells Magnolol a b s t r a c t In this work, the influence of Magnolol on the bystander effect in alpha-particle irradiated

  15. {alpha}-particle spectrum in the reaction p + {sup 11}B {yields} {alpha} + {sup 8}Be* {yields} 3{alpha}

    SciTech Connect

    Dmitriev, V. F., E-mail: dmitriev@inp.nsk.s [Budker Institute of Nuclear Physics (Russian Federation)

    2009-07-15

    Using a simple phenomenological parametrization of the reaction amplitude we calculated {alpha}-particle spectrumin the reaction p + {sup 11}B {yields} {alpha} + {sup 8}Be* {yields} 3{alpha} at the resonance proton energy of 675 keV. The parametrization includes Breit-Wigner factor with an energy-dependent width for intermediate {sup 8}Be* state and the Coulomb and the centrifugal factors in {alpha}-particle-emission vertices. The shape of the spectrum consists of a well-defined peak corresponding to emission of the primary {alpha} and a flat shoulder going down to very low energy. We found that below 1.5MeV there are 17.5% of {alpha}'s and below 1MeV there are 11% of them.

  16. Control of alpha-particle transport by ion cyclotron resonance heating

    SciTech Connect

    Chang, C.S.; Imre, K.; Weitzner, H.; Colestock, P. (Princeton Univ., NJ (United States). Plasma Physics Lab.)

    1990-12-01

    In this paper control of radial alpha-particle transport by using ion cyclotron range of frequency (ICRF) waves is investigated in a large-aspect-ratio tokamak geometry. Spatially inhomogeneous ICRF wave energy with properly selected frequencies and wave numbers can induce fast convective transports of alpha particles at the speed of order v{sub {alpha}} {approximately} (P{sub RF}/n{sub {alpha}}{epsilon}{sub 0}){rho}{sup p}, where R{sub RF} is the ICRF wave power density, n{sub {alpha}} is the alpha-particle density, {epsilon}{sub 0} is the alpha-particle birth energy, and {rho}{sub p} is the poloidal gyroradius of alpha particles at the birth energy. Application to International Thermonuclear Experimental Reactor (ITER) plasma is studied and possible antenna designs to control alpha-particle flux are discussed.

  17. Alpha-particle physics in the tokamak fusion test reactor DT experiment

    Microsoft Academic Search

    S. J. Zweben; V. Arunasalam; S. H. Batha; R. V. Budny; C. E. Bush; S. Cauffman; C. S. Chang; Z. Chang; C. Z. Cheng; D. S. Darrow; R. O. Dendy; H. H. Duong; N. J. Fisch; E. D. Fredrickson; R. K. Fisher; R. J. Fonck; G. Y. Fu; V. Goloborod'ko; N. Gorelenkov; R. J. Hawryluk; R. Heeter; W. W. Heidbrink; H. W. Herrmann; M. Herrmann; D. W. Johnson; J. Machuzak; R. Majeski; K. M. McGuire; G. McKee; S. S. Medley; H. E. Mynick; R. Nazikian; M. P. Petrov; M. H. Redi; S. Reznik; J. Rogers; G. Schilling; D. A. Spong; J. D. Strachan; B. C. Stratton; E. Synakowski; G. Taylor; S. Wang; R. B. White; K. L. Wong; V. Yavorski

    1997-01-01

    A summary is presented of recent alpha-particle experiments on the tokamak fusion test reactor. Alpha particles are generally well confined in MHD-quiescent discharges, and alpha heating of electrons has been observed. The theoretically predicted toroidicity-induced Alfvén eigenmode has been seen in discharges of <= 1 MW of alpha power, but only in plasmas with weak magnetic shear.

  18. SPECIAL TOPIC: Alpha particle physics experiments in the Tokamak Fusion Test Reactor

    NASA Astrophysics Data System (ADS)

    Zweben, S. J.; Budny, R. V.; Darrow, D. S.; Medley, S. S.; Nazikian, R.; Stratton, B. C.; Synakowski, E. J.; Taylor, G.; TFTR Group

    2000-01-01

    Alpha particle physics experiments were done on TFTR during its DT run from 1993 to 1997. These experiments utilized several new alpha particle diagnostics and hundreds of DT discharges to characterize the alpha particle confinement and wave-particle interactions. In general, the results from the alpha particle diagnostics agreed with the classical single particle confinement model in MHD quiescent discharges. The alpha loss due to toroidal field ripple was identified in some cases, and the low radial diffusivity inferred for high energy alphas was consistent with orbit averaging over small scale turbulence. Finally, the observed alpha particle interactions with sawteeth, toroidal Alfvén eigenmodes and ICRF waves were approximately consistent with theoretical modelling. What was learned is reviewed and what remains to be understood is identified.

  19. AlphaRad, a new integrated CMOS System-On-Chip for high efficiency alpha particle counting.

    E-print Network

    Paris-Sud XI, Université de

    1 AlphaRad, a new integrated CMOS System-On-Chip for high efficiency alpha particle counting. D * corresponding author : daniel.husson@ires.in2p3.fr Abstract An integrated System-on-Chip (SoC) has been designed; #12;2 Key words: Solid state detectors; System-on-chip; Alpha particles; Neutrons. The field

  20. Alpha-particle Measurements Needed for Burning Plasma Experiments

    SciTech Connect

    Kenneth M. Young

    2001-09-26

    The next major step in magnetic fusion studies will be the construction of a burning plasma (BP) experiment where the goals will be to achieve and understand the plasma behavior with the internal heating provided by fusion-generated alpha particles. Two devices with these physics goals have been proposed: the International Thermonuclear Experimental Reactor (ITER) and the Fusion Ignition Research Experiment (FIRE). Extensive conceptual design work for the instrumentation to try to meet the physics demands has been done for these devices, especially ITER. This article provides a new look at the measurements specifically important for understanding the physics aspects of the alpha particles taking into account two significant events. The first is the completion of physics experiments on the Joint European Torus (JET) and the Tokamak Fusion Test Reactor (TFTR) with deuterium-tritium fueling with the first chances to study alpha physics and the second is the realization that relatively compact plasmas, making use of advanced tokamak plasma concepts, are the most probable route to burning plasmas and ultimately a fusion reactor.

  1. Self-consistent study of the alpha particle driven TAE mode

    SciTech Connect

    Wu, Y.; White, R.B.

    1994-04-01

    The interaction of high energy particles with an Alfven eigenmode is investigated self-consistently by using a realistic kinetic dispersion relation. All important poloidal mode numbers and their radial mode profiles as calculated with the NOVA-K code are included. A Hamiltonian guiding center code is used to simulate the alpha particle motion. The numerical simulations include particle orbit width, nonlinear particle dynamics and the effects of the modes on the particles. Modification of the particle distribution leading to mode saturation is observed. Particle loss is limited to devices in which the alpha particle gyro radius is a significant fraction of the minor radius.

  2. GaN-based PIN alpha particle detectors

    NASA Astrophysics Data System (ADS)

    Wang, Guo; Fu, Kai; Yao, Chang-sheng; Su, Dan; Zhang, Guo-guang; Wang, Jin-yan; Lu, Min

    2012-01-01

    GaN-based PIN alpha particle detectors are studied in this article. The electrical properties of detectors have been investigated, such as current-voltage ( I- V) and capacitance-voltage ( C- V). The reverse current of all detectors is in nA range applied at 30 V, which is suitable for detector operation. The charge collection efficiency (CCE) is measured to be approximately 80% but the energy resolution is calculated to be about 40% mostly because the intrinsic layer is not sufficiently thick enough.

  3. Radiolytic gas production in the alpha particle degradation of plastics

    SciTech Connect

    Reed, D.T.; Hoh, J.; Emery, J. (Argonne National Lab., IL (United States)); Hobbs, D. (Westinghouse Savannah River Co., Aiken, SC (United States))

    1992-01-01

    Net gas generation due to alpha particle irradiation of polyethylene and polyvinyl chloride was investigated. Experiments were performed in an air environment at 30, 60, and 100{degree}C. The predominant radiolytic degradation products of polyethylene were hydrogen and carbon dioxide with a wide variety of trace organic species noted. Irradiation of polyvinyl chloride resulted in the formation of HCl in addition to the products observed for polyethylene. For both plastic materials, a strong enhancement of net yields was noted at 100{degree}C.

  4. Radiolytic gas production in the alpha particle degradation of plastics

    SciTech Connect

    Reed, D.T.; Hoh, J.; Emery, J. [Argonne National Lab., IL (United States); Hobbs, D. [Westinghouse Savannah River Co., Aiken, SC (United States)

    1992-05-01

    Net gas generation due to alpha particle irradiation of polyethylene and polyvinyl chloride was investigated. Experiments were performed in an air environment at 30, 60, and 100{degree}C. The predominant radiolytic degradation products of polyethylene were hydrogen and carbon dioxide with a wide variety of trace organic species noted. Irradiation of polyvinyl chloride resulted in the formation of HCl in addition to the products observed for polyethylene. For both plastic materials, a strong enhancement of net yields was noted at 100{degree}C.

  5. Particle-Mesh Simulations of the Lyman-Alpha Forest

    E-print Network

    A. Meiksin; M. White

    2000-08-15

    Numerical hydrodynamical simulations have proven a successful means of reproducing many of the statistical properties of the Lyman-Alpha forest as measured in high redshift quasar spectra. Pseudo-hydrodynamical methods based only on simulating the dark matter component have been claimed to yield a comparable level of success. We investigate the degree to which two pseudo-methods, with and without allowing for a pseudo-gas pressure, are able to match the predictions of fully hydrodynamical plus dark matter simulations. We also address the requirements for convergence to the statistics of the spectra and the inferred properties of the Lyman-Alpha forest as a function of resolution and box size. Generally we find it is possible to reach agreement with full hydrodynamic simulations at the 10% level in the cumulative distributions of the flux and absorption line parameter statistics for readily achievable particle and grid numbers, but difficult to do much better.

  6. Profiles and parameters of tracks in the LR115 detector irradiated with alpha particles

    E-print Network

    Yu, K.N.

    Profiles and parameters of tracks in the LR115 detector irradiated with alpha particles D. Nikezic particles. Some differences between the behavior of CR39 and LR115 detectors are discussed. Track parameters have been calculated and plotted for the CR39 detector irradiated with alpha particles [11]. Another

  7. Two-electron capture from helium by fast [alpha] particles

    SciTech Connect

    Belkic, D.; Mancev, I.; Mudrinic, M. (University of Stockholm, Atomic Physics, Frescativaegen 24, S-104 05 Stockholm (Sweden) Institute of Physics, P.O. Box 57, 11001 Belgrade (Yugoslavia) Department of Physics, University of Nis, P.O. Box 91, 18001 Nis (Yugoslavia))

    1994-05-01

    Two-electron capture from helium by fast [alpha] particles is investigated. Working within the four-body framework of scattering theory, we perform detailed computations for differential as well as total cross sections, by means of the second-order Born distorted-wave (BDW) approximation, and find good agreement with the available experimental data. We also report the results obtained by means of the continuum distorted-wave (CDW) method in both the four-body formalism and the independent-particle model. The former fails to reproduce the measurement, whereas the latter emerges as a satisfactory method for [alpha]-He double-charge exchange. The reported study of the electronic continuum intermediate states clearly indicates that double-charge exchange is remarkably sensitive to inclusion of these long-range Coulomb effects, even at incident energies at which the Thomas double scattering is completely unimportant. This is in sharp contrast to the familiar situation at the comparable energies encountered in treating single-electron transfer in ion-atom collisions.

  8. Enhanced production of low energy electrons by alpha particle impact.

    PubMed

    Kim, Hong-Keun; Titze, Jasmin; Schöffler, Markus; Trinter, Florian; Waitz, Markus; Voigtsberger, Jörg; Sann, Hendrik; Meckel, Moritz; Stuck, Christian; Lenz, Ute; Odenweller, Matthias; Neumann, Nadine; Schössler, Sven; Ullmann-Pfleger, Klaus; Ulrich, Birte; Fraga, Rui Costa; Petridis, Nikos; Metz, Daniel; Jung, Annika; Grisenti, Robert; Czasch, Achim; Jagutzki, Ottmar; Schmidt, Lothar; Jahnke, Till; Schmidt-Böcking, Horst; Dörner, Reinhard

    2011-07-19

    Radiation damage to living tissue stems not only from primary ionizing particles but to a substantial fraction from the dissociative attachment of secondary electrons with energies below the ionization threshold. We show that the emission yield of those low energy electrons increases dramatically in ion-atom collisions depending on whether or not the target atoms are isolated or embedded in an environment. Only when the atom that has been ionized and excited by the primary particle impact is in immediate proximity of another atom is a fragmentation route known as interatomic Coulombic decay (ICD) enabled. This leads to the emission of a low energy electron. Over the past decade ICD was explored in several experiments following photoionization. Most recent results show its observation even in water clusters. Here we show the quantitative role of ICD for the production of low energy electrons by ion impact, thus approaching a scenario closer to that of radiation damage by alpha particles: We choose ion energies on the maximum of the Bragg peak where energy is most efficiently deposited in tissue. We compare the electron production after colliding He(+) ions on isolated Ne atoms and on Ne dimers (Ne(2)). In the latter case the Ne atom impacted is surrounded by a most simple environment already opening ICD as a deexcitation channel. As a consequence, we find a dramatically enhanced low energy electron yield. The results suggest that ICD may have a significant influence on cell survival after exposure to ionizing radiation. PMID:21730184

  9. Alpha particle transport in the presence of toroidal driftwaves

    NASA Astrophysics Data System (ADS)

    Nishimura, Y.; Huang, B.; Cheng, C. Z.

    2013-10-01

    Transport of fusion born ? particles is investigated in the presence of poloidally mode coupled ballooning type driftwaves. The onset of orbit stochasticity is understood as an overlapping of electric islands produced by the driftwaves, whose overlapping threshold is lower for the thermal particles than for the ? particles (high energy particles). For the trapped particles, transport is determined by the particles' sensitive response to the fluctuation at the banana tip where the parallel velocity decreases drastically. Time dependent turbulent signals (finite ?* effects) give rise to the shift of the resonant radial locations, which again is larger for the thermal particles than the high energy particles. The transport process is influenced by the microscopic structure of the islands, which deviates from the Gaussian process. This work is supported by National Science Council of Taiwan, NSC 100-2112-M-006-021-MY3 and NCKU Top University Project.

  10. A self-consistent theory of collective alpha particle losses induced by Alfvenic turbulence

    SciTech Connect

    Biglari, H. [Princeton Univ., NJ (United States). Plasma Physics Lab.; Diamond, P.H. [California Univ., San Diego, La Jolla, CA (United States). Dept. of Physics

    1992-01-01

    The nonlinear dynamics of kinetic Alfven waves, resonantly excited by energetic ions/alpha particles, is investigated. It is shown that {alpha}-particles govern both linear instability and nonlinear saturation dynamics, while the background MHD turbulence results only in a nonlinear real frequency shift. The most efficient saturation mechanism is found to be self-induced profile modification. Expressions for the fluctuation amplitudes and the {alpha}-particle radial flux are self-consistently derived. The work represents the first self-consistent, turbulent treatment of collective {alpha}-particle losses by Alfvenic fluctuations.

  11. Relative biological effectiveness of alpha particles at radon exposure.

    PubMed

    Zhukovsky, M; Bastrikova, N; Vasilyev, A

    2015-06-01

    The relative biological effectiveness (RBE) of alpha particles at radon exposure is estimated by comparison of radiation risks at external gamma exposure and radon exposure in different situations. For external gamma exposure, the BEIR VII model of radiation risk assessment was used. For occupational and indoor radon exposure, models such as BEIR VI, WISMUT, Tomasek's and combined miners population were considered. It was demonstrated that RBE values are strongly dependent on models of radiation risk assessment used for RBE calculation, sex of exposed peoples and age at the exposure. The average values of RBE in dependence on model of risk assessment choice are in the range from 1.5 to 12.0 for males and in the range from 0.34 to 2.7 for females. PMID:25979745

  12. Alpha particle losses from Tokamak Fusion Test Reactor deuterium-tritium plasmas

    SciTech Connect

    Darrow, D.S.; Zweben, S.J. [Princeton Univ., NJ (United States). Plasma Physics Lab.] [Princeton Univ., NJ (United States). Plasma Physics Lab.; Batha, S. [Fusion Physics and Technology, Torrance, CA (United States)] [Fusion Physics and Technology, Torrance, CA (United States)

    1996-01-01

    Because alpha particle losses can have a significant influence on tokamak reactor viability, the loss of deuterium-tritium alpha particles from the Tokamak Fusion Test Reactor (TFTR) has been measured under a wide range of conditions. In TFTR, first orbit loss and stochastic toroidal field ripple diffusion are always present. Other losses can arise due to magnetohydrodynamic instabilities or due to waves in the ion cyclotron range of frequencies. No alpha particle losses have yet been seen due to collective instabilities driven by alphas. Ion Bernstein waves can drive large losses of fast ions from TFTR, and details of those losses support one element of the alpha energy channeling scenario.

  13. Realizing the potential of the Actinium-225 radionuclide generator in targeted alpha particle therapy applications.

    PubMed

    Miederer, Matthias; Scheinberg, David A; McDevitt, Michael R

    2008-09-01

    Alpha particle-emitting isotopes have been proposed as novel cytotoxic agents for augmenting targeted therapy. Properties of alpha particle radiation such as their limited range in tissue of a few cell diameters and their high linear energy transfer leading to dense radiation damage along each alpha track are promising in the treatment of cancer, especially when single cells or clusters of tumor cells are targeted. Actinium-225 (225 Ac) is an alpha particle-emitting radionuclide that generates 4 net alpha particle isotopes in a short decay chain to stable 209 Bi, and as such can be described as an alpha particle nanogenerator. This article reviews the literature pertaining to the research, development, and utilization of targeted 225 Ac to potently and specifically affect cancer. PMID:18514364

  14. A CMOS integrated pulse mode alpha-particle counter for application in radon monitoring

    SciTech Connect

    Ahmed, A.; Walkey, D.J.; Tarr, N.G. [Carleton Univ., Ottawa, Ontario (Canada). Dept. of Electronics] [Carleton Univ., Ottawa, Ontario (Canada). Dept. of Electronics

    1997-06-01

    A custom integrated circuit for detecting alpha particles for application in the monitoring of radon has been designed and tested. The design uses the reverse-biased well to a substrate capacitance of a p-n junction in a conventional CMOS process as a sense capacitor for incident alpha particles. A simple CMOS inverter is used as an analog amplifier to detect the small potential change induced by an alpha-particle strike on the sense capacitor. The design was implemented in a 1.2-{micro}m conventional CMOS process with a sense capacitor area of 110 {micro}m{sup 2}. Tests carried out under vacuum conditions using a calibrated {sup 241}Am alpha-particle source showed an output voltage swing of {ge}2.0 V for an alpha event. The detector is also shown to have good immunity to noise and high-quantum efficiency for alpha particles.

  15. An alpha particle instrument with alpha, proton, and X-ray modes for planetary chemical analyses

    NASA Technical Reports Server (NTRS)

    Economou, T. E.; Turkevich, A. L.

    1976-01-01

    The interaction of alpha particles with matter is employed in a compact instrument that could provide rather complete in-situ chemical analyses of surfaces and thin atmospheres of extraterrestrial bodies. The instrument is a miniaturized and improved version of the Surveyor lunar instrument. The backscattering of alpha particles and (alpha, p) reactions provide analytical data on the light elements (carbon-iron). An X-ray mode that detects the photons produced by the alpha sources provides sensitivity and resolution for the chemical elements heavier than about silicon. The X-rays are detected by semiconductor detectors having a resolution between 150 and 250 eV at 5.9 keV. Such an instrument can identify and determine with good accuracy 99 percent of the atoms (except hydrogen) in rocks. For many trace elements, the detecting sensitivity is a few ppm. Auxiliary sources could be used to enhance the sensitivities for elements of special interest. The instrument could probably withstand the acceleration involved in semi-hard landings.

  16. Intense alpha-particle emitting crystallites in uranium mill wastes

    USGS Publications Warehouse

    Landa, E.R.; Stieff, L.R.; Germani, M.S.; Tanner, A.B.; Evans, J.R.

    1994-01-01

    Nuclear emulsion microscopy has demonstrated the presence of small, intense ??-particle emitting crystallites in laboratory-produced tailings derived from the sulfuric acid milling of uranium ores. The ??-particle activity is associated with the isotope pair 210Pb 210Po, and the host mineral appears to be PbSO4 occurring as inclusions in gypsum laths. These particles represent potential inhalation hazards at uranium mill tailings disposal areas. ?? 1994.

  17. Enhanced homologous recombination is induced by alpha-particle radiation in somatic cells of Arabidopsis thaliana

    NASA Astrophysics Data System (ADS)

    Bian, Po; Liu, Ping; Wu, Yuejin

    Almost 9 percent of cosmic rays which strike the earth's atmosphere are alpha particles. As one of the ionizing radiations (IR), its biological effects have been widely studied. However, the plant genomic instability induced by alpha-particle radiation was not largely known. In this research, the Arabidopsis thaliana transgenic for GUS recombination substrate was used to evaluate the genomic instability induced by alpha-particle radiation (3.3MeV). The pronounced effects of systemic exposure to alpha-particle radiation on the somatic homologous recombination frequency (HRF) were found at different doses. The 10Gy dose of radiation induced the maximal HRF which was 1.9-fold higher than the control. The local radiation of alpha-particle (10Gy) on root also resulted in a 2.5-fold increase of somatic HRF in non-radiated aerial plant, indicating that the signal(s) of genomic instability was transferred to non-radiated parts and initiated their genomic instability. Concurrent treatment of seedlings of Arabidopsis thaliana with alpha-particle and DMSO(ROS scavenger) both in systemic and local radiation signifi- cantly suppressed the somatic HR, indicating that the free radicals produced by alpha-particle radiation took part in the production of signal of genomic instability rather than the signal transfer. Key words: alpha-particle radiation, somatic homologous recombination, genomic instability

  18. A global 2.5-dimensional three fluid solar wind model with alpha particles

    Microsoft Academic Search

    Bo Li; Xing Li; Nicolas Labrosse

    2006-01-01

    A global 2.5-dimensional three fluid solar wind model is presented. Two ion species, namely protons and alpha particles, are heated by an empirical energy flux while electrons are heated by the classical heat flux and Coulomb coupling with ions. It is found that for a reasonable relative speed between alpha particles and protons at 1 AU to be achieved, the

  19. WIND Measurements of Proton and Alpha Particle Flow and Number Density J. T. Steinberg

    E-print Network

    Richardson, John

    for investigating the interplanetary edium. The solar wind experiment (SWE) on WIND e e includes 2 Faraday cup-alpha particle differential flow can s a be determined. We present early SWE Faraday cup result nd compare proton detectors for measuring th nergy/charge spectrum of solar wind protons and alpha f t particles. The Faraday

  20. Ion Densities and Particle Charges for Alpha Ionization in an Aerosol Atmosphere: Columnar Recombination Corrections

    Microsoft Academic Search

    Y. S. Mayya; W. Holländer

    1995-01-01

    Ionization by alpha sources in an environment containing small aerosol particles is of interest in aerosol neutralizes, particle chargers and atmospheric electricity. It is known that the conventional ion-balance equation is inadequate in describing the bulk ion densities for alpha sources in view of the columnar recombination process. An earlier self-consistent formulation to include this effect is extended to the

  1. Anomalous loss of DT alpha particles in the Tokamak Fusion Test Reactor

    SciTech Connect

    Herrmann, H.W.

    1997-09-01

    An escaping alpha collector probe has been developed for TFTR`s DT phase. Energy distributions of escaping alphas have been determined by measuring the range of {alpha}-particles implanted into nickel foils located within the alpha collector. Results at 1.0 MA of plasma current are in good agreement with predictions for first orbit alpha loss. Results at 1.8 MA, however, show a significant anomalous loss of partially thermalized alphas (in addition to the expected first orbit loss), which is not observed with the lost alpha scintillator detectors in DT plasmas, but does resemble the anomalous delayed loss seen in DD plasmas. None of the candidate explanations proposed thus far are fully consistent with the anomalous loss observations. An experiment designed to study the effect of plasma major radius shifts on {alpha}-particle loss has led to a better understanding of {alpha}-particle dynamics in tokamaks. Intuitively, one might suppose that confined marginally passing {alpha}-particles forced to move toward higher magnetic field during an inward major radius shift (i.e., compression) would mirror and become trapped particles, leading to increased alpha loss. Such an effect was looked for during the shift experiment, however, no significant changes in alpha loss to the 90{degree} lost alpha scintillator detector were observed during the shifts. It is calculated that the energy gained by an {alpha}-particle during the inward shift is sufficient to explain this result. However, an unexpected loss of partially thermalized {alpha}-particles near the passing/trapped boundary was observed to occur between inward and outward shifts at an intermediate value of plasma current (1.4 MA). This anomalous loss feature is not yet understood.

  2. Use of /sup 3/He/sup + +/ ICRF minority heating to simulate alpha particle heating

    DOEpatents

    Post, D.E. Jr.; Hwang, D.Q.; Hovey, J.

    1983-11-16

    It is an object of the present invention to provide a better understanding of alpha particle behavior in a magnetically confined, energetic plasma. Another object of the present invention is to provide an improved means and method for studying and measuring the energy distribution of heated alpha particles in a confined plasma. Yet another object of the present invention is to permit detailed analysis of energetic alpha particle behavior in a magnetically confined plasma for use in near term fusion reactor experiments. A still further object of the present invention is to simulate energetic alpha particle behavior in a deuterium-tritium plasma confined in a fusion reactor without producing the neutron activation associated with the thus produced alpha particles.

  3. Anomalous Loss of DT Alpha Particles in the Tokamak Fusion Test Reactor

    SciTech Connect

    Herrmann, Hans W.

    1997-06-01

    Princeton's Tokamak Fusion Test Reactor (TFTR) is the first experimental fusion device to routinely use tritium to study the deuterium-tritium (DT) fusion reaction,allowing the first systematic study of DT alpha particles in tokamak plasmas. A crucial aspect of alpha-particle physics is the fraction of alphas that escape from the plasma, particularly since these energetic particles can do severe damage to the first wall of a reactor. An escaping alpha collector probe has been developed for TFTR's DT phase. Energy distributions of escaping alphas have been determined by measuring the range of alpha-particles implanted into nickel foils located within the alpha collector. Results at 1.0 MA of plasma current are in good agreement with predictions for first orbit alpha loss. Results at 1.8 MA, however, show a significant anomalous loss of partially thermalized alphas (in addition to the expected first orbit loss), which is not observed with the lost alpha scintillator detectors in DT plasmas, but does resemble the anomalous "delayed" loss seen in DD plasmas. None of the candidate explanations proposed thus far are fully consistent with the anomalous loss observations. An experiment designed to study the effect of plasma major radius shifts on alpha-particle loss has led to a better understanding of alpha-particle dynamics in tokamaks. Intuitively, one might suppose that confined marginally passing alpha-particles forced to move toward higher magnetic field during an inward major radius shift (i.e. compression) would mirror and become trapped particles, leading to increased alpha loss. Such an effect was looked for during the shift experiment, however, no significant changes in alpha loss to the 90 degree lost alpha scintillator detector were observed during the shifts. It is calculated that the energy gained by an alpha-particle during the inward shift is sufficient to explain this result. However, an unexpected loss of partially thermalized alpha-particles near the passing/trapped boundary was observed to occur between inward and outward shifts at an intermediate value of plasma current (1.4 MA). This anomalous loss feature is not yet understood.

  4. Simulation of Alpha Particles in Rotating Plasma Interacting with a Stationary Ripple

    SciTech Connect

    Abraham J. Fetterman and Nathaniel J. Fisch

    2011-01-11

    Superthermal ExB rotation can provide magnetohydrodynamic (MHD) stability and enhanced confinement to axisymmetric mirrors. However, the rotation speed has been limited by phenomena at end electrodes. A new prediction is that rotation might instead be produced using a magnetic ripple and alpha particle kinetic energy, in an extension of the alpha channeling concept. The interaction of alpha particles with the ripple results in visually interesting and practically useful orbits.

  5. Experimental determination of LR115 detector efficiency for exposure to alpha particles

    Microsoft Academic Search

    D Marocco; F Bochicchio

    2001-01-01

    The alpha particle detection efficiency of LR-115 detectors has been measured against alpha particle energy E and incidence angle ? (with respect to the normal to the detector surface), using an experimental apparatus with an 241Am alpha source and air in a pressure-controlled chamber as the degrading medium, and a spark-counter for counting tracks. About 200 LR-115 detectors were exposed

  6. PPPL-3253, Preprint: June 1997, UC-420, 426, 427 Alpha Particle Loss in TFTR Deuterium-Tritium Plasmas

    E-print Network

    PPPL-3253, Preprint: June 1997, UC-420, 426, 427 Alpha Particle Loss in TFTR Deuterium-Tritium ions. This paper presents calculations of guiding-center code alpha particle orbit loss from deuterium-tritium

  7. Alpha particles induce apoptosis through the sphingomyelin pathway.

    PubMed

    Seideman, Jonathan H; Stancevic, Branka; Rotolo, Jimmy A; McDevitt, Michael R; Howell, Roger W; Kolesnick, Richard N; Scheinberg, David A

    2011-10-01

    The sphingomyelin pathway involves the enzymatic cleavage of sphingomyelin to produce ceramide, a second messenger that serves as a key mediator in the rapid apoptotic response to various cell stressors. Low-linear energy transfer (LET) ? radiation can initiate this pathway, independent of DNA damage, via the cell membrane. Whether short-ranged, high-LET ? particles, which are of interest as potent environmental carcinogens, radiotherapies and potential components of dirty bombs, can act through this mechanism to signal apoptosis is unknown. Here we show that irradiation of Jurkat cells with ? particles emitted by the ²²?Ac-DOTA-anti-CD3 IgG antibody construct results in dose-dependent apoptosis. This apoptosis was significantly reduced by pretreating cells with cholesterol-depleting nystatin, a reagent known to inhibit ceramide signaling by interfering with membrane raft coalescence and ceramide-rich platform generation. The effects of nystatin on ?-particle-induced apoptosis were related to disruption of the ceramide pathway and not to microdosimetry alterations, because similar results were obtained after external irradiation of the cells with a broad beam of collimated ? particles using a planar ²?¹Am source. External irradiation allowed for more precise control of the dosimetry and geometry of the irradiation, independent of antibody binding or cell internalization kinetics. Mechanistically consistent with these findings, Jurkat cells rapidly increased membrane concentrations of ceramide after external irradiation with an average of five ?-particle traversals per cell. These data indicate that ? particles can activate the sphingomyelin pathway to induce apoptosis. PMID:21631289

  8. Energetic/alpha particle effects on MHD modes and transport

    SciTech Connect

    Cheng, C.Z.; Budny, R. [Princeton Univ., NJ (United States). Plasma Physics Lab.; Chen, L. [Univ. of California, Irvine, CA (United States). Dept. of Physics

    1995-01-01

    A nonvariational kinetic-MHD stability code (NOVA-K) has been employed to study TAE stability in TFRR D-T and DIII-D experiments and to achieve understanding of TAE instability drive and damping mechanism. Reasonably good agreement between theory and experiment has been obtained. In these experiments the dominant damping mechanism is due to both the thermal ion Landau damping and/or the beam ion Landau damping. Based on ITER EDA parameters, the TAE modes are expected to be unstable in normal ITER operations. Energetic particle transport has been studied using a test particle code (ORBIT). Energetic particle loss scales linearly with the TAE mode amplitude and can be large for TFRR and DIII-D for {delta}B{sub r}/B > 10{sup {minus}4} due to large banana orbit. From quasi-linear (ORBIT) and nonlinear kinetic-MHD (MH3D-K) simulations the saturation of TAE modes is due to nonlinear wave particle trapping and energetic particle profile modification in both radial and energy space. Finally, a convective bucket transport mechanism by MHD waves with time-dependent frequency is presented. Based on the energy-selective characteristics of the bucket transport mechanism, undesirable particles such as helium ash can be removed from the plasma core efficiently.

  9. Behavior of low-energy protons and alpha particles during a disturbed time period

    NASA Technical Reports Server (NTRS)

    Ipavich, F. M.; Gloeckler, G.; Fan, C. Y.; Hovestadt, D.

    1976-01-01

    The paper presents observations of 130- to 1200-keV protons and 40- to 420-keV/nucleon alpha particles made on the earth-orbiting spacecraft Imp 8 and Imp 7 during an active solar period in September 1974, concentrating, in particular, on an energetic storm particle (ESP) event observed in association with an interplanetary shock wave on September 21. It is found that the observed variations in the proton-to-alpha particle ratios and spectral indices can be explained either by 'pileup' or by acceleration models of ESP events. Several instances of local acceleration of particles in the near-earth environment are also discussed.

  10. On resonant excitations of high-n magnetohydrodynamic modes by energetic/alpha particles in tokamaks

    SciTech Connect

    Chen, Liu

    1989-03-01

    Analytical theories for the excitations in tokamaks of magnetohydrodynamic (MHD) modes with large toroidal mode numbers (n>>1) are presented. Specifically, only instability mechanisms due to resonances with energetic ions/alpha particles are considered. It is noted that, while trapped energetic particles contribute to the ideal region, circulating energetic particles contribute mainly to the singular layer dynamics. A unified dispersion relation manifesting both fishbone-like modes and beam transit-resonance modes is then driven. Finally, we also analyze the stability property of toroidicity-induced shear Alfven waves excited via transit resonances with alpha particles in ignited tokamaks. 11 refs.

  11. WIND measurements of proton and alpha particle flow and number density

    NASA Technical Reports Server (NTRS)

    Steinberg, J. T.; Lazarus, A. J.; Ogilvie, J. T.; Lepping, R.; Byrnes, J.; Chornay, D.; Keller, J.; Torbert, R. B.; Bodet, D.; Needell, G. J.

    1995-01-01

    We propose to review measurements of the solar wind proton and alpha particle flow velocities and densities made since launch with the WIND SWE instrument. The SWE Faraday cup ion sensors are designed to be able to determine accurately flow vector directions, and thus can be used to detect proton-alpha particle differential flow. Instances of differential flow, and the solar wind features with which they are associated will be discussed. Additionally, the variability of the percentage of alpha particles as a fraction of the total solar wind ion density will be presented.

  12. Feasibility study on the use of polyallyldiglycol-carbonate cell dishes in TUNEL assay for alpha particle radiobiological experiments

    E-print Network

    Yu, K.N.

    on polyallyldiglycol-carbonate (PADC) films to investigate the effects of alpha particles on HeLa cervix cancer cells to investigate the effects of alpha particles on HeLa cervix cancer cells. To directly provide evidence alpha particle hit positions. A special method involving ``base tracks'' for aligning the images of cell

  13. Alpha Particles Induce Apoptosis through the Sphingomyelin Pathway

    PubMed Central

    Seideman, Jonathan H.; Stancevic, Branka; Rotolo, Jimmy A.; McDevitt, Michael R.; Howell, Roger W.; Kolesnick, Richard N.; Scheinberg, David A.

    2011-01-01

    The sphingomyelin pathway involves the enzymatic cleavage of sphingomyelin to produce ceramide, a second messenger that serves as a key mediator in the rapid apoptotic response to various cell stressors. Low-linear energy transfer (LET) ? radiation can initiate this pathway, independent of DNA damage, via the cell membrane. Whether short-ranged, high-LET a particles, which are of interest as potent environmental carcinogens, radiotherapies and potential components of dirty bombs, can act through this mechanism to signal apoptosis is unknown. Here we show that irradiation of Jurkat cells with a particles emitted by the 225Ac-DOTA-anti-CD3 IgG antibody construct results in dose-dependent apoptosis. This apoptosis was significantly reduced by pretreating cells with cholesterol-depleting nystatin, a reagent known to inhibit ceramide signaling by interfering with membrane raft coalescence and ceramide-rich platform generation. The effects of nystatin on ?-particle-induced apoptosis were related to disruption of the ceramide pathway and not to microdosimetry alterations, because similar results were obtained after external irradiation of the cells with a broad beam of collimated a particles using a planar 241Am source. External irradiation allowed for more precise control of the dosimetry and geometry of the irradiation, independent of antibody binding or cell internalization kinetics. Mechanistically consistent with these findings, Jurkat cells rapidly increased membrane concentrations of ceramide after external irradiation with an average of five ?-particle traversals per cell. These data indicate that a particles can activate the sphingomyelin pathway to induce apoptosis. PMID:21631289

  14. Measurement of the Internal Magnetic Field of Plasmas using an Alpha Particle Source

    SciTech Connect

    S.J. Zweben; D.S. Darrow; P.W. Ross; J.L. Lowrance; G. Renda

    2004-05-13

    The internal magnetic fields of plasmas can be measured under certain conditions from the integrated v x B deflection of MeV alpha particles emitted by a small radioactive source. This alpha source and large-area alpha particle detector would be located inside the vacuum vessel but outside the plasma. Alphas with a typical energy of 5.5 MeV (241Am) can reach the center of almost all laboratory plasmas and magnetic fusion devices, so this method can potentially determine the q(r) profile of tokamaks or STs. Orbit calculations, background evaluations, and conceptual designs for such a vxB (or ''AVB'') detector are described.

  15. Alpha particle driven current and torque in ITER baseline scenarios with 3D perturbations

    NASA Astrophysics Data System (ADS)

    Snicker, A.; Asunta, O.; Ylitie, H.; Kurki-Suonio, T.; Schneider, M.; Pinches, S. D.

    2015-06-01

    In this paper three-dimensional (3D) kinetic Monte Carlo orbit-following simulations are carried out with the ASCOT code to estimate the alpha particle driven current and torque profiles in ITER baseline scenarios. Several different 3D magnetic field configurations, including TF ripple, ferritic inserts, test blanket modules and edge localized mode coil perturbations, are used in these simulations. The alpha particle current is found to be less than one percent for all configurations and scenarios. In axisymmetric magnetic field configurations, the collisional and j × B torque components cancel each other, whilst in non-axisymmetric cases, the total torque is nonzero. The total alpha driven torque is found to oppose that generated by the neutral beam injection particles and to be an order of magnitude smaller. Consequently, alpha particles will not significantly contribute to the plasma current nor act as a source of plasma rotation in the ITER baseline scenarios considered.

  16. Influence of rotation-induced nuclear deformation on. alpha. -particle evaporation spectra

    SciTech Connect

    Huizenga, J.R.; Behkami, A.N.; Govil, I.M.; Schroder, W.U.; Toke, J. (Department of Chemistry and Nuclear Structure Research Laboratory, University of Rochester, Rochester, New York 14627 (US))

    1989-08-01

    The shapes of {alpha}-particle spectra from hot, high-spin compound nuclei produced in energetic heavy-ion fusion reactions are analyzed within the framework of a statistical model. Contrary to claims made in the literature, good agreement is obtained between calculated and experimental spectra when the evaporation barrier of each nuclide in the complex cascade is assumed equal to its respective absorption channel barrier. The dependence of the shape of {alpha}-particle spectra on nuclear deformation is discussed both in terms of the transmission coefficients and the spin-dependent level density of deformed nuclei. For deformations of the magnitude given by the rotating liquid drop model, {alpha}-particle spectra and effective barriers are insensitive to whether deformed or spherical nucleus transmission coefficients are used. It is important, however, to include the deformation dependence in the nuclear level density. Model calculations indicate that the shape of {alpha}-particle spectra may be quite insensitive to large deformations.

  17. Direct and indirect effects of alpha-particle irradiations of human prostate tumor cells

    E-print Network

    Wang, Rong, Ph. D. Massachusetts Institute of Technology

    2005-01-01

    The objective of this project is to establish a model system to study the direct effect, the bystander effect and the combinational effect of alpha-particle irradiations of human prostate tumor cells, toward the goal of ...

  18. Angular distribution of {alpha} particles from oriented {sup 253,254}Es and {sup 255}Fm nuclei

    SciTech Connect

    Severijns, N.; Golovko, V.V.; Kraev, I.S.; Phalet, T. [Instituut voor Kern- en Stralingsfysica, K.U. Leuven, B-3001 Leuven (Belgium); Belyaev, A.A.; Lukhanin, A.A.; Noga, V.I. [Kharkov Institute of Physics and Technology, 61108 Kharkov (Ukraine); Erzinkyan, A.L.; Parfenova, V.P. [Institute of Nuclear Physics, Moscow State University, 119992 Moscow (Russian Federation); Eversheim, P.-D.; Herzog, P.; Tramm, C. [Helmholtz Institute fuer Strahlen- und Kernphysik, Universitaet Bonn, D-53115 Bonn (Germany); Filimonov, V.T.; Toporov, Yu.G.; Zotov, E. [Research Institute for Atomic Reactors, 433510 Dimitrovgrad-10 (Russian Federation); Gurevich, G.M.; Rusakov, A.V. [Institute for Nuclear Research, Russian Academy of Sciences, 119312, Moscow (Russian Federation); Vyachin, V.N. [RFNC All-Russian Scientific Research Institute of Experimental Physics, 607190 Sarov (Russian Federation); Zakoucky, D. [Nuclear Physics Institute, Academy of Sciences of Czech Republic, CZ-25068 Rez (Czech Republic)

    2005-04-01

    The anisotropy in the angular distribution of {alpha} particles from oriented {sup 253,254}Es and {sup 255}Fm nuclei, which are among the strongest deformed {alpha} emitters, was measured. Large {alpha} anisotropies have been observed for all three nuclei. The results are compared with calculations based on {alpha}-particle tunneling through a deformed Coulomb barrier.

  19. {alpha}-particle optical potentials for nuclear astrophysics (NA) and nuclear technology (NT)

    SciTech Connect

    Avrigeanu, V.; Avrigeanu, M. [Horia Hulubei National Institute for Physics and Nuclear Engineering, POBox MG-6, 077125 Magurele, Ilfov (Romania)

    2012-11-20

    The high precision of recent measurements for low-energy {alpha}-particle elastic-scattering as well as induced-reaction data makes possible the understanding of actual limits and possible improvement of the global optical model potentials parameters. Involvement of recent optical potentials for reliable description of both the elastic scattering and emission of {alpha}-particles, of equal interest for nuclear astrophysics (NA) and nuclear technology (NT) for fusion devices, is discussed in the present work.

  20. Alpha-particle interactions with nuclei at 12A GeV/c

    SciTech Connect

    Claesson, G.; Garpman, S.; Lund, I.; Otterlund, I.; Stenlund, E.; Soederstroem, K.; Bhalla, K.B.; Bharti, A.; Kumar, V.; Lokanathan, S.

    1986-05-01

    Pseudorapidity-density distributions of shower particles from 12A-GeV/c ..cap alpha..-emulsion interactions are presented. As compared to extrapolations from p-nucleus data, the central ..cap alpha..+(Ag,Br) interactions exhibit an excess of particles in the middle pseudorapidity region. The correlation between and can be understood within a wounded-nucleon model.

  1. Physical aspects of precise spectrometry of alpha-particles with silicon pn-junction detectors

    Microsoft Academic Search

    E. Verbitskaya; V. Eremin; N. Strokan; J. Kemmer; B. Schmidt; J. von Borany

    1994-01-01

    Investigations of energy and charge losses have been carried out for silicon planar alpha-particle detectors. The detectors were manufactured by an advanced technology, using ion implantation and various annealing temperatures. A detailed analysis of the recombination processes in alpha-particle tracks with a high electron-hole density and a measurement procedure for the main parameters of charge carrier loss have been developed.

  2. High-spin particle states in 151Sm studied with the (alpha, 3He) reaction

    Microsoft Academic Search

    G. Løvhøiden; J. R. Lien; J. C. Waddington; J. Rekstad; I. Espe; C. Gaarde; J. S. Larsen; S. van der Werf

    1981-01-01

    High-spin states have been located in 151Sm by means of the (alpha, 3He) reaction with 40 MeV alpha-particles. The scattered particles were momentum analyzed in a QMG\\/2 magnetic spectrometer and recorded in a position sensitive detector. Several high-spin states were observed in the energy range below 1.7 MeV excitation. The previously unknown strongly populated levels at 867 and 1480 keV

  3. High-spin particle states in 153Sm studied with the (alpha, 3He) reaction

    Microsoft Academic Search

    J. R. Lien; G. Løvhøiden; J. Rekstad; A. Henriques; C. Gaarde; J. S. Larsen; S. Y. van der Werf

    1984-01-01

    High-spin states have been located in 153Sm by means of the (alpha, 3He) reaction with 40 MeV alpha-particles. The scattered particles were momentum-analysed in a QMG\\/2 magnetic spectrometer and recorded in a position-sensitive detector. Several high-spin states were observed below 2 MeV of excitation. Strongly populated levels at 698, 1118 and 1708 keV can most likely be interpreted as 13\\/2+

  4. Evaluation of ZnO(Ga)Coatings as Alpha Particle Transducers Within a Neutron Generator

    Microsoft Academic Search

    J. T. Mihalczo; J. S. Neal; J. C. Cooper; D. S. Koltick

    2002-01-01

    We report investigations and preliminary results from efforts to develop a recoil alpha particle detector for use in a portable neutron generator. The associated particle sealed tube neutron generator (APSTNG) will be used as an interrogation source for the Nuclear Materials Identification System (NMIS). With the emission of 14.1 MeV neutrons produced by the D-T reaction, associated 3.5 MeV alpha

  5. Relative determination of W-values for alpha particles in tissue-equivalent and other gases

    Microsoft Academic Search

    G L Krieger; J W Baum; M N Varma; J L Beach

    1979-01-01

    W (the average energy to form an ion pair) for 5.4 MeV 241Am alpha particles in a Rossi-type tissue-equivalent (TE) gas, argon and methane was determined to an accuracy better than 0.2% using a new automated data handling system. A vibrating reed electrometer and current digitiser were used to measure the current produced by completely stopping the alpha particles in

  6. Energy dependence of the differential W-value of alpha particles in tissue-equivalent gas

    Microsoft Academic Search

    J. Booz; Th Smit; A. Waker

    1972-01-01

    The linear ion density of alpha -particles of energies 0.27 to 5.3 MeV was measured in tissue-equivalent gas. The results were compared with experimental and theoretical mass stopping powers in order to evaluate the differential W-value of alpha -particles, walpha . Above 1.6 MeV walpha was within 3% agreement with Winfinity , the constant W-value of electrons. For low energies

  7. IV. ALPHA-PARTICLE PHYSICS IN BPX D. J. SIGMAR (MIT)

    E-print Network

    al- FUSION TECHNOLOGY VOL. 21 MAY 1992 pha power balance that the coupling parameter qa E [Pa distribution (fa) averaged al- pha pressure including the effect of ur, on the ki- netic equation for fa. (For. Quantitative measurements of 7"" due to al- pha particles require Q 2 2. 1113 #12;Sigmar ALPHA-PARTICLE PHYSICS

  8. MIRD Pamphlet No. 22 (Unabridged): Radiobiology and Dosimetry of alpha-Particle Emitters for Targeted Radionuclide Therapy

    SciTech Connect

    Sgouros, George; Roeske, John C.; McDevitt, Michael S.; Palm, Stig; Allen, Barry J.; Fisher, Darrell R.; Brill, Bertrand A.; Song, Hong; Howell, R. W.; Akabani, Gamal

    2010-02-28

    The potential of alpha-particle emitters to treat cancer has been recognized since the early 1900s. Advances in the targeted delivery of radionuclides, in radionuclide conjugation chemistry, and in the increased availability of alpha-emitters appropriate for clinical use have recently led to patient trials of alpha-particle-emitter labeled radiopharmaceuticals. Although alpha-emitters have been studied for many decades, their current use in humans for targeted therapy is an important milestone. The objective of this work is to review those aspects of the field that are pertinent to targeted alpha-particle-emitter therapy and to provide guidance and recommendations for human alpha-particle-emitter dosimetry.

  9. LIMITS ON ALPHA PARTICLE TEMPERATURE ANISOTROPY AND DIFFERENTIAL FLOW FROM KINETIC INSTABILITIES: SOLAR WIND OBSERVATIONS

    SciTech Connect

    Bourouaine, Sofiane; Verscharen, Daniel; Chandran, Benjamin D. G. [Space Science Center, University of New Hampshire, Durham, NH 03824 (United States)] [Space Science Center, University of New Hampshire, Durham, NH 03824 (United States); Maruca, Bennett A. [Space Science Laboratory, University of California, Berkeley, CA 94720 (United States)] [Space Science Laboratory, University of California, Berkeley, CA 94720 (United States); Kasper, Justin C., E-mail: s.bourouaine@unh.edu [Harvard-Smithsonian Center for Astrophysics, Cambridge, MA 02138 (United States)

    2013-11-01

    Previous studies have shown that the observed temperature anisotropies of protons and alpha particles in the solar wind are constrained by theoretical thresholds for pressure and anisotropy driven instabilities such as the Alfvén/ion-cyclotron (A/IC) and fast-magnetosonic/whistler (FM/W) instabilities. In this Letter, we use a long period of in situ measurements provided by the Wind spacecraft's Faraday cups to investigate the combined constraint on the alpha proton differential flow velocity and the alpha particle temperature anisotropy due to A/IC and FM/W instabilities. We show that the majority of the data are constrained to lie within the region of parameter space in which A/IC and FM/W waves are either stable or have extremely low growth rates. In the minority of observed cases in which the growth rate of the A/IC (FM/W) instability is comparatively large, we find relatively higher values of T {sub ?}/T {sub p} (T {sub ??}/T {sub ?p}) when the alpha proton differential flow velocity is small, where T {sub ?} and T {sub p} (T {sub ??} and T {sub ?p}) are the perpendicular (parallel) temperatures of alpha particles and protons. We conjecture that this observed feature might arise from preferential alpha particle heating which can drive the alpha particles beyond the instability thresholds.

  10. Limits on Alpha Particle Temperature Anisotropy and Differential Flow from Kinetic Instabilities: Solar Wind Observations

    NASA Astrophysics Data System (ADS)

    Bourouaine, Sofiane; Verscharen, Daniel; Chandran, Benjamin D. G.; Maruca, Bennett A.; Kasper, Justin C.

    2013-11-01

    Previous studies have shown that the observed temperature anisotropies of protons and alpha particles in the solar wind are constrained by theoretical thresholds for pressure and anisotropy driven instabilities such as the Alfvén/ion-cyclotron (A/IC) and fast-magnetosonic/whistler (FM/W) instabilities. In this Letter, we use a long period of in situ measurements provided by the Wind spacecraft's Faraday cups to investigate the combined constraint on the alpha proton differential flow velocity and the alpha particle temperature anisotropy due to A/IC and FM/W instabilities. We show that the majority of the data are constrained to lie within the region of parameter space in which A/IC and FM/W waves are either stable or have extremely low growth rates. In the minority of observed cases in which the growth rate of the A/IC (FM/W) instability is comparatively large, we find relatively higher values of T ?/T p (T ??/T ?p ) when the alpha proton differential flow velocity is small, where T ? and T p (T ?? and T ?p ) are the perpendicular (parallel) temperatures of alpha particles and protons. We conjecture that this observed feature might arise from preferential alpha particle heating which can drive the alpha particles beyond the instability thresholds.

  11. Modification of alpha-particle emission spectrum in beam-injected deuterium-tritium plasmas

    SciTech Connect

    Matsuura, H.; Nakao, Y. [Department of Applied Quantum Physics and Nuclear Engineering, Kyushu University, Motooka, Fukuoka 819-0395 (Japan)

    2009-04-15

    The alpha ({alpha})-particle and neutron emission spectra in a deuterium-tritium plasma accompanied with neutral-beam-injection (NBI) heating are evaluated in a consistent way by solving the Boltzmann-Fokker-Planck equations for deuteron, triton, and {alpha}-particle simultaneously. It is shown that owing to the existence of non-Maxwellian tail component in fuel-ion distribution function due to NBI and/or nuclear elastic scattering, the generation rate of the energetic ({>=}4 MeV) {alpha}-particle increases significantly. When 20 MW intense deuterium beam with 1 MeV beam-injection energy is injected into an 800 m{sup 3} plasma (T{sub e}=10 keV, n{sub e}=6.2x10{sup 19} m{sup -3}), the enhancement of the fraction of the power carried by {alpha}-particles with energy above 4 (3.9) MeV to total {alpha}-particle power is almost twice (1.5 times) as much from the value for Gaussian distribution. A verification scenario for the modification of the emission spectrum by using the gamma ({gamma})-ray-generating {sup 9}Be({alpha},n{gamma}){sup 12}C reaction is also presented.

  12. The Effects of Alpha Particle Confinement on Burning Plasma Tokamak Performance

    NASA Astrophysics Data System (ADS)

    Gormley, Robert P.

    In this thesis, three effects of alpha particle plasma interactions on the global performance of a fusion reactor are studied, namely, (i) the energy coupling efficiency of the fast alpha particles with the bulk plasma, (ii) the relationship between imperfect alpha energy coupling to the bulk plasma and the resultant alpha particle/helium ash fuel dilution; and (iii) the neoclassical bootstrap current induced by fusion born alpha particles calculated self-consistently with the plasma equilibrium. First, the ion drift kinetic equation for the high energy alpha particles is reduced from the exact five dimensional form to a two dimensional form in radius r and energy E (plus time t). The resulting slowing-down diffusion equation is solved by a multiple energy group method. A theoretically based anomalous diffusion coefficient D_sp{alpha}{an} is then introduced from a self-consistent alpha particle Alfven wave turbulence solution (by F. Gang), in which D_sp{alpha}{an } itself depends on the gradient in alpha density. The temporal and spatial behavior of eta_ alpha is analyzed for an ITER-CDA physics phase fusion reactor. We find that eta_ alpha can be as low as 0.95 depending on the plasma operating temperature. Next, the relationship between the alpha-particle power coupling efficiency and the actual alpha-particle power that is coupled with the bulk plasma is investigated, this time taking into account the concomitant helium ash accumulation. It is found that the coupled power varies less than linearly with eta_alpha and is, in fact, significantly depressed for eta_alpha near unity. Combining these effects with a thermal power balance shows that the high temperature "thermally stable" side of the ignition boundary is pushed toward lower temperatures if either D_alpha increases (which results in a lower eta_alpha) or the helium-ash confinement time lengthens. This is a consequence of strengthened fuel dilution and imperfect alpha power coupling. Implications on the thermal stability of a fusion reactor are also discussed. Lastly, we calculate the alpha particle induced bootstrap current produced, while retaining the effects of slowing-down drag, pitch-angle scattering, and arbitrary aspect ratio. The alpha drift kinetic equation is solved for the alpha bootstrap current density; and the resulting expression inserted into a simple cylindrical Ampere's Law. In addition, the alpha bootstrap current is more rigorously solved, self-consistently, with the full 2-D Grad-Shafranov equilibrium equations for three currently conceived tokamaks: TPX, ITER-CDA and ITER-EDA. In particular, the effect of varying plasma Zeff on the alpha bootstrap current is investigated. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617 -253-5668; Fax 617-253-1690.).

  13. Nuclear reactions induced by high-energy alpha particles

    NASA Technical Reports Server (NTRS)

    Shen, B. S. P.

    1974-01-01

    Experimental and theoretical studies of nuclear reactions induced by high energy protons and heavier ions are included. Fundamental data needed in the shielding, dosimetry, and radiobiology of high energy particles produced by accelerators were generated, along with data on cosmic ray interaction with matter. The mechanism of high energy nucleon-nucleus reactions is also examined, especially for light target nuclei of mass number comparable to that of biological tissue.

  14. Absorbed fractions for alpha-particles in tissues of cortical bone

    NASA Astrophysics Data System (ADS)

    Watchman, Christopher J.; Bolch, Wesley E.

    2009-10-01

    Bone-seeking alpha-particle emitting radionuclides are common health physics hazards. Additionally, they are under consideration as an option for therapeutic molecular radiotherapy applications. Current dose models do not account for energy or bone-site dependence as shown by alpha-particle absorbed fractions given in ICRP Publication 30. Energy-dependent, yet bone-site independent, alpha-particle absorbed fractions have been presented by the models of Stabin and Siegel (2003 Health Phys. 85 294-310). In this work, a chord-based computational model of alpha-particle transport in cortical bone has been developed that explicitly accounts for both the bone-site and particle-energy dependence of alpha-particle absorbed fractions in this region of the skeleton. The model accounts for energy deposition to three targets: cortical endosteum, haversian space tissues and cortical bone. Path length distributions for cortical bone given in Beddoe (1977 Phys. Med. Biol. 22 298-308) provided additional transport regions in the absorbed fraction calculation. Significant variations in absorbed fractions between different skeletal sites were observed. Differences were observed between this model and the absorbed fractions given in ICRP Publication 30, which varied by as much as a factor of 2.1 for a cortical bone surface source irradiating cortical endosteum.

  15. Use of .sup.3 He.sup.30 + ICRF minority heating to simulate alpha particle heating

    DOEpatents

    Post, Jr., Douglass E. (Belle Mead, NJ); Hwang, David Q. (Lawrencevill, NJ); Hovey, Jane (Plainsboro, NJ)

    1986-04-22

    Neutron activation due to high levels of neutron production in a first heated deuterium-tritium plasma is substantially reduced by using Ion Cyclotron Resonance Frequency (ICRF) heating of energetic .sup.3 He.sup.++ ions in a second deuterium-.sup.3 He.sup.++ plasma which exhibit an energy distribution and density similar to that of alpha particles in fusion reactor experiments to simulate fusion alpha particle heating in the first plasma. The majority of the fast .sup.3 He.sup.++ ions and their slowing down spectrum can be studied using either a modulated hydrogen beam source for producing excited states of He.sup.+ in combination with spectrometers or double charge exchange with a high energy neutral lithium beam and charged particle detectors at the plasma edge. The maintenance problems thus associated with neutron activation are substantially reduced permitting energetic alpha particle behavior to be studied in near term large fusion experiments.

  16. Bose-Einstein condensation of {alpha} particles and Airy structure in nuclear rainbow scattering

    SciTech Connect

    Ohkubo, S. [Department of Applied Science and Environment, Kochi Women's University, Kochi 780-8515 (Japan); Hirabayashi, Y. [Information Initiative Center, Hokkaido University, Sapporo 060-0810 (Japan)

    2004-10-01

    It is shown that the dilute density distribution of {alpha} particles in nuclei can be observed in the Airy structure in nuclear rainbow scattering. We have analyzed {alpha}+{sup 12}C rainbow scattering to the 0{sub 2}{sup +} (7.65 MeV) state of {sup 12}C in a coupled-channel method with the precise wave functions for {sup 12}C. It is found that the enhanced Airy oscillations in the experimental angular distributions for the 0{sub 2}{sup +} state is caused by the dilute density distribution of this state in agreement for the idea of Bose-Einstein condensation of the three alpha particles.

  17. Theory of energetic/alpha particle effects on magnetohydrodynamic modes in tokamaks

    SciTech Connect

    Chen, L.; White, R.B.; Rewoldt, G.; Colestock, P.; Rutherford, P.H.; Chen, Y.P.; Ke, F.J.; Tsai, S.T.; Bussac, M.N.

    1989-01-01

    The presence of energetic particles is shown to qualitatively modify the stability properties of ideal as well as resistive magnetohydrodynamic (MHD) modes in tokamaks. Specifically, we demonstrate that, consistent with highpower ICRF heating experiments in JET, high energy trapped particles can effectively stabilize the sawtooth mode, providing a possible route to stable high current tokamak operation. An alternative stabilization scheme employing barely circulating energetic particles is also proposed. Finally, we present analytical and numerical studies on the excitations of high-n MHD modes via transit resonances with circulating alpha particles. 14 refs., 3 figs.

  18. CR-SA hysteresis phenomenon on the basis of alpha-particle satellite data

    NASA Astrophysics Data System (ADS)

    Dorman, L. I.; Iucci, N.; Parisi, M.; Villoresi, G.

    We analyzed satellite 5-min data on alpha-particle fluxes in energy intervals 60-160 MeV, 160-260 MeV and 330-500 MeV during January 1986 -- May 2000. In the first we excluded periods with great CR increases caused by particle acceleration in solar flare events. Then we determined monthly averaged fluxes as well as 5 months and 11 months smooth averaged data. We corrected these data on drift effects according to the procedure described in Dorman (2004) in dependence of alpha-particle energies. Corrected on drifts alpha-particles fluxes we compare with expected according to convection-diffusion modulation for different values of supposed dimension of the modulation region (measured by time of solar wind propagation from the Sun to the boundary of this region Xo from 1 to 60 av. months; described in Dorman, 2004). By this way we can determine Xomax, at what the correlation coefficient reaches the maximum value. Then it can be determined the dimension of modulation region (with taking into account the influence of nonlinear processes on the solar wind speed in the outer Heliosphere according to Le Roux and Fichtner, 1997), the radial diffusion coefficient and transport path as well as expected alpha-particle intensity out of the modulation region and absolute alpha-particle modulation (relative to the alpha-particle intensity level in the interstellar space). References: Dorman L.I. ``Expected relative role of drift and convection-diffusion mechanisms in global small energy cosmic ray modulation''. Paper, submitted on the Session D1.2 of COSPAR 2004. Le Roux J.A. and H. Fichtner ``The influence of pickup, anomalous, and galactic cosmic ray protons on the structure of the heliospheric shock: a self consistent approach'', Astrophys. J, 477, L115-L118, 1997.

  19. Destabilization of planar lipid bilayers by. cap alpha. particles from polonium-210

    SciTech Connect

    Nelson, G.A.

    1984-01-01

    A system for measuring the interacton between ..cap alpha.. particles from /sup 210/Polonium and planar lipid bilayers is described. Membrane capacitance and conductance were simultaneously measured with a voltage clamp. A micrometer advance mechanism was used to control the position of a /sup 210/Polonium source with respect to a bowed-out bilayer. Conductance records showed an abrupt failure of the bilayer when the source was approximately 30 microns or less from the bilayer. Comparisons of conductance noise characteristics just prior to membrane breakage and noise characteristics with a source - bilayer separation of 50 microns or greater showed no difference. The range of the ..cap alpha.. particles inferred from observations of membrane failure is consistent with the expected maximum range of approximately 35 microns for ..cap alpha.. particles from the particular gold-covered source in water. The breakage mechanism is not directly peroxide-mediated as experiments with added peroxide alone did not show significant alterations. The breakdown of lipid bilayers by ..cap alpha.. particles may be analogous to the observations in a set of experiments which showed ..cap alpha.. particle destabilization of surfactant films in air. Evidence supports the hypothesis that free radicals generated in the bilayer, as opposed to aqueous solution free radicals, are the most important agent for bilayer destabilization.

  20. Alpha Particles Play a Relatively Minor Role in Magnetized Target Fusion Systems

    SciTech Connect

    Ryutov, D.D. [Lawrence Livermore National Laboratory (United States)

    2002-03-15

    Two problems related to alpha particle physics in magnetized target fusion (MTF) systems are briefly discussed. First, we evaluate the pressure and density of alpha particles under the assumption that they are perfectly confined and have a classical slowing-down distribution. It turns out that because of a comparatively low plasma temperature in MTF systems, the relative pressure and density of alpha particles are more than an order of magnitude less than in fusion reactors based on ITER-type tokamaks. Therefore, one may expect that even in the extreme case of a perfect confinement of alpha particles, their presence will have a much weaker (than in the case of tokamaks) effect on plasma stability and transport. Second, we discuss the kinetics of plasma burn under the opposite extreme assumption that all the alpha particles are instantaneously lost, without leaving any energy in a plasma. It turns out that even in this case, the plasma energy yield in batch-burn systems is only weakly affected by burnout effects.

  1. Effects of alpha-particles on survival and chromosomal aberrations in human mammary epithelial cells

    NASA Technical Reports Server (NTRS)

    Durante, M.; Grossi, G. F.; Gialanella, G.; Pugliese, M.; Nappo, M.; Yang, T. C.

    1995-01-01

    We have studied the radiation responses of a human mammary epithelial cell line, H184B5 F5-1 M/10. This cell line was derived from primary mammary cells after treatment with chemicals and heavy ions. The F5-1 M/10 cells are immortal, density-inhibited in growth, and non-tumorigenic in athymic nude mice and represent an in vitro model of the human epithelium for radiation studies. Because epithelial cells are the target of alpha-particles emitted from radon daughters, we concentrated our studies on the efficiency of alpha-particles. Confluent cultures of M/10 cells were exposed to accelerated alpha-particles [beam energy incident at the cell monolayer = 3.85 MeV, incident linear energy transfer (LET) in cell = 109 keV/microns] and, for comparison, to 80 kVp x-rays. The following endpoints were studied: (1) survival, (2) chromosome aberrations at the first postirradiation mitosis, and (3) chromosome alterations at later passages following irradiation. The survival curve was exponential for alpha-particles (D0 = 0.73 +/- 0.04 Gy), while a shoulder was observed for x-rays (alpha/beta = 2.9 Gy; D0 = 2.5 Gy, extrapolation number 1.6). The relative biological effectiveness (RBE) of high-LET alpha-particles for human epithelial cell killing was 3.3 at 37% survival. Dose-response curves for the induction of chromosome aberrations were linear for alpha-particles and linearquadratic for x-rays. The RBE for the induction of chromosome aberrations varied with the type of aberration scored and was high (about 5) for chromosome breaks and low (about 2) for chromosome exchanges.(ABSTRACT TRUNCATED AT 250 WORDS).

  2. Simple experimental method for alpha particle range determination in lead iodide films.

    PubMed

    Dmitriev, Yuri; Bennett, Paul R; Cirignano, Leonard J; Klugerman, Mikhail; Shah, Kanai S

    2007-05-01

    An experimental method for determining the range of alpha particles in films based on I-V(s) analysis has been suggested. The range of 5.5 MeV alpha particles in PbI(2) films determined by this technique is 30+/-5 microm, and this value is in agreement with the value calculated by SRIM (the stopping and range of ions in matter), r=24 microm in PbI(2). More than 100 I-V(s) of PbI(2) films with different thicknesses and quality have been analyzed, and the influence of alpha particle radiation on PbI(2) I-V(s) curves has been studied. Developed analytical methods (dependence of current density on electric field and conception of surface defects) were used, and the method limitations are discussed. It was shown that I-V(s) demonstrate the tendency to obey Ohm's law under alpha radiation. On the other hand, dark conductivity of the lead iodide films shows a typical impure character that can lead to an overestimation of the alpha particles' range in PbI(2) films. After films were exposed to alpha radiation, the dark resistivity and I-V shape of some films improved. Also, a weak decrease of the charge carrier concentration, due to a decrease of the "surface defect" concentration ("surface refining"), was registered after successive measurements of I-V(s). PMID:17552841

  3. Cross section balance in the 14N + 159Tb reaction and the origin of fast alpha particles

    NASA Astrophysics Data System (ADS)

    Siemssen, R. H.; Balster, G. J.; Wilschut, H. W.; Bond, P. D.; Crouzen, P. C. N.; Goldhoorn, P. B.; Shukui, Han; Sujkowski, Z.

    1985-10-01

    Exclusive cross sections have been obtained from particle-K X-ray coincidence data measured at 236 MeV for ejectiles ranging from 4He to 15N. Production cross sections for primary fragments and alpha particle multiplicities associated with different channels have been deduced. The major fraction of the alpha particles appears to originate from inelastic (damped) processes in which only light particles with Z ? 2 are emitted.

  4. High resolution alpha particle detectors based on 4H-SiC epitaxial layer

    NASA Astrophysics Data System (ADS)

    Zat'ko, B.; Dubecký, F.; Šagátová, A.; Sedla?ová, K.; Ry?, L.

    2015-04-01

    We fabricated and characterized 4H-SiC Schottky diodes as a spectrometric detector of alpha particles. A thin blocking contact of Ni/Au (15 nm) was used to minimize the influence on alpha particles energy. Current-voltage characteristics of the detector were measured and a low current density below 0.3 nAcm?2 was observed at room temperature. 239Pu241Am244Cm was used as a source of alpha particles within the energy range between 5.1 MeV and 5.8 MeV for detector testing. The charge collection efficiency close to 100 % at reverse bias exceeding 50 V was determined. The best spectrometric performance shows a pulse height spectrum at a reverse bias of 200 V giving an energy resolution of 0.25 % in the full width and half maximum for 5.486 MeV of 241Am.

  5. A study of the effects of MeV alpha particles in PE and PVDC

    SciTech Connect

    Evelyn, A.L.; Ila, D.; Zimmerman, R.L.; Bhat, K. [Center for Irradiation of Materials, Departments of Physics and Chemistry, Alabama AM University, P.O. Box 1447, Normal, Alabama 35762-1447 (United States); Poker, D.B.; Hensley, D.K. [Solid State Division, Oak Ridge National Laboratory, P.O. Box 2008, MS 6048, Oak Ridge, Tennessee 37831 (United States)

    1997-02-01

    We have mapped and studied the effects of MeV alpha-particle bombardment in polyvinylidene chloride (PVDC) and polyethylene (PE). We used 3.5 and 5.0 MeV alpha-particle incident beams and stacked polymer films to separate the contributing effects of the electronic ({var_epsilon}{sub e}) and nuclear ({var_epsilon}{sub n}) stopping powers. The electrical conductance and change in the chemical structures were measured by direct resistivity measurement, Raman microprobe, RBS and FTIR. The results indicate significant differences in the ({var_epsilon}{sub e}) and ({var_epsilon}{sub n}) effects at higher alpha-particle bombardment fluences. {copyright} {ital 1997 American Institute of Physics.}

  6. Rigidity-independent coronal propagation and escape of solar protons and alpha particles

    NASA Technical Reports Server (NTRS)

    Perron, C.; Domingo, V.; Reinhard, R.; Wenzel, K.-P.

    1978-01-01

    In a study of rigidity-independent coronal propagation processes, data on the azimuthal variation of the solar proton/alpha-particle ratio were obtained. Sources for the data included a statistical analysis of events observed by Heos-2, a comparative study of events recorded by both Heos-2 and Pioneer-10 and -11, and a multiday survey of individual events observed by Heos-2 and Pioneer-10. The statistical investigation of Heos-2 events reveals an increase of the lower value of the proton/alpha-particle ratio away from the well-connected region. The data from one or two spacecraft connected at different heliolongitudes indicates no azimuthal dependence of the proton/alpha-particle ratio. All the data appear to suggest rigidity-independent propagation or escape processes.

  7. Investigation of alpha particle induced single-event upsets in charge-coupled devices

    NASA Astrophysics Data System (ADS)

    Pepper, Gary T.; Fechete, Andrew

    1991-12-01

    The mechanisms for generation of single-event upsets (SEUs) in a linear charge coupled device (CCD) were studied through irradiation with monoenergetic 5.48 MeV alpha particles from a very low flux Am source. Spatial correlation (cluster analysis) of soft errors due to single alpha particle hits was demonstrated to be a necessary prerequisite for quantitative analysis of different SEU error-generating phenomena. The Texas Instruments TC-103 virtual phase CCD used in this study is shown to be sensitive to alpha particles not only in the vicinity of photosites as expected, but also in the transport CCDs. This latter effect may have adverse consequences for applications employing CCDs as position-sensitive ionizing radiation detectors. The techniques developed in this work for the analysis of one dimensional arrays is readily extensible to two dimensional CCD arrays.

  8. Prediction of Lung Cells Oncogenic Transformation for Induced Radon Progeny Alpha Particles Using Sugarscape Cellular Automata

    PubMed Central

    Baradaran, Samaneh; Maleknasr, Niaz; Setayeshi, Saeed; Akbari, Mohammad Esmaeil

    2014-01-01

    Background Alpha particle irradiation from radon progeny is one of the major natural sources of effective dose in the public population. Oncogenic transformation is a biological effectiveness of radon progeny alpha particle hits. The biological effects which has caused by exposure to radon, were the main result of a complex series of physical, chemical, biological and physiological interactions. The cellular and molecular mechanisms for radon-induced carcinogenesis have not been clear yet. Methods Various biological models, including cultured cells and animals, have been found useful for studying the carcinogenesis effects of radon progeny alpha particles. In this paper, sugars cape cellular automata have been presented for computational study of complex biological effect of radon progeny alpha particles in lung bronchial airways. The model has included mechanism of DNA damage, which has been induced alpha particles hits, and then formation of transformation in the lung cells. Biomarkers were an objective measure or evaluation of normal or abnormal biological processes. In the model, the metabolism rate of infected cell has been induced alpha particles traversals, as a biomarker, has been followed to reach oncogenic transformation. Results The model results have successfully validated in comparison with “in vitro oncogenic transformation data” for C3H 10T1/2 cells. This model has provided an opportunity to study the cellular and molecular changes, at the various stages in radiation carcinogenesis, involving human cells. Conclusion It has become well known that simulation could be used to investigate complex biomedical systems, in situations where traditional methodologies were difficult or too costly to employ. PMID:25250147

  9. Enhanced retention of the alpha-particle-emitting daughters of Actinium-225 by liposome carriers.

    PubMed

    Sofou, Stavroula; Kappel, Barry J; Jaggi, Jaspreet S; McDevitt, Michael R; Scheinberg, David A; Sgouros, George

    2007-01-01

    Targeted alpha-particle emitters hold great promise as therapeutics for micrometastatic disease. Because of their high energy deposition and short range, tumor targeted alpha-particles can result in high cancer-cell killing with minimal normal-tissue irradiation. Actinium-225 is a potential generator for alpha-particle therapy: it decays with a 10-day half-life and generates three alpha-particle-emitting daughters. Retention of (225)Ac daughters at the target increases efficacy; escape and distribution throughout the body increases toxicity. During circulation, molecular carriers conjugated to (225)Ac cannot retain any of the daughters. We previously proposed liposomal encapsulation of (225)Ac to retain the daughters, whose retention was shown to be liposome-size dependent. However, daughter retention was lower than expected: 22% of theoretical maximum decreasing to 14%, partially due to the binding of (225)Ac to the phospholipid membrane. In this study, Multivesicular liposomes (MUVELs) composed of different phospholipids were developed to increase daughter retention. MUVELs are large liposomes with entrapped smaller lipid-vesicles containing (225)Ac. PEGylated MUVELs stably retained over time 98% of encapsulated (225)Ac. Retention of (213)Bi, the last daughter, was 31% of the theoretical maximum retention of (213)Bi for the liposome sizes studied. MUVELs were conjugated to an anti-HER2/neu antibody (immunolabeled MUVELs) and were evaluated in vitro with SKOV3-NMP2 ovarian cancer cells, exhibiting significant cellular internalization (83%). This work demonstrates that immunolabeled MUVELs might be able to deliver higher fractions of generated alpha-particles per targeted (225)Ac compared to the relative fractions of alpha-particles delivered by (225)Ac-labeled molecular carriers. PMID:17935286

  10. Distributions of Alpha Particles Escaping to the Wall because of Sawtooth Oscillations in TFTR

    SciTech Connect

    Kolesnichenko, Ya.I.; Lutsenko, V.V.; White, R.B.; Yakovenko, Yu.V., Zweben, S.J.

    1998-11-01

    It has been observed experimentally in deuterium-tritium shots of the Tokamak Fusion Test Reactor (TFTR) that crashes of sawtooth oscillations may result in very inhomogeneous flux of alpha particles to the wall. Namely, measurements with four detectors installed at the wall at 20°, 45°, 60°, and 90° below the midplane of the torus have shown that the alpha flux to the wall is strongly peaked at the 20° and 90° detectors and on the noise level at the 45° detector. To explain this phenomenon, both theoretical analysis and numerical simulation have been carried out. It is concluded that the "crash-induced prompt loss," i.e., the orbital loss of marginally trapped particles arising because of the crash-induced orbit transformation of circulating particles, is responsible for the flux to the 90° and 60° detectors, whereas the crash-induced stochastic diffusion of moderately trapped particles explains the large signal at the 20° detector. The calculated poloidal distributions of the integral alpha flux are in reasonable agreement with experimental data. In addition to the integral flux, the flux of particles with given energy was calculated. The energy spectrum of the escaping particles has also been calculated, which can be used for diagnostics of the crash type.

  11. Annealing effect of the 6H-SiC semiconductor detector for alpha particles

    Microsoft Academic Search

    J. H. HA; S. M. Kang; S. H. Park; H. S. Kim; Y. H. Cho; J. H. Lee; N. H. Lee; J. B. Kim; Y. K. Kim

    2008-01-01

    Alpha-particle detectors based on 6H-SiC semiconductor were fabricated and their electrical and radiation performances were measured. Detector structure was Au\\/Ni\\/6H-SiC\\/Ni\\/Au multi-layer structure. The current–voltage characteristics of the SiC detectors were measured and the radiation response was evaluated by 238Pu with 5.5MeV alpha particles at room temperature in air. The 6H-SiC detectors were annealed by a rapid temperature annealing (RTA) device

  12. Map model for nonlinear alpha particle interaction with toroidal Alfven waves

    SciTech Connect

    Berk, H.L.; Breizman, B.N.; Ye, H.

    1992-09-01

    A map model has been developed for studying the nonlinear interaction of alpha particles with the toroidal Alfven eigenmodes. The map is constructed by assuming a linear interaction during a single poloidal transit, which allows the study of the nonlinear interaction over many transits. By using this map, analytic expressions are obtained for the particle nonlinear bounce frequency, and the wave amplitude threshold for the onset of particle orbit stochasticity. The map model can also facilitate self-consistent simulations which incorporate the time variation of the waves.

  13. Investigation of thermal and slowing-down alpha particles on JET using charge-exchange spectroscopy

    Microsoft Academic Search

    M. von Hellermann; W. Mandl; H. P. Summers; A. Boileau; R. Hoekstra; F. J. de Heer; J. Frieling

    1991-01-01

    Thermal alpha particles are observed in JET during helium discharges using spectral emission in He II (n=4 to 3) near 4685 AA following charge transfer reactions along the path of the neutral deuterium heating beams. New and reappraised He22\\/H charge transfer cross-sections are presented. The effects of cross-section energy dependence on temperatures, velocities and absolute densities deduced from thermal alpha

  14. Alpha particle condensation in {sup 12}C and nuclear rainbow scattering

    SciTech Connect

    Ohkubo, S. [Department of Applied Science and Environment, Kochi Women's University, Kochi 780-8515 (Japan); Hirabayashi, Y. [Information Initiative Center, Hokkaido University, Sapporo 060-0811 (Japan)

    2008-05-12

    It is shown that the large radius of the Hoyle state of {sup 12}C with a dilute density distribution in an {alpha} particle condensate can be clearly seen in the shift of the rainbow angle (therefore the Airy minimum) to a larger angle in {alpha}+{sup 12}C rainbow scattering at the high energy region and prerainbow oscillations in {sup 3}He+{sup 12}C scattering at the lower energy region.

  15. Track reconstruction and performance of DRIFT directional dark matter detectors using alpha particles

    Microsoft Academic Search

    S. Burgos; J. Forbes; C. Ghag; M. Gold; V. A. Kudryavtsev; T. B. Lawson; D. Loomba; P. Majewski; D. Muna; A. St J. Murphy; G. G. Nicklin; S. M. Paling; A. Petkov; S. J. S. Plank; M. Robinson; N. Sanghi; N. J. T. Smith; D. P. Snowden-Ifft; N. J. C. Spooner; T. J. Sumner; J. Turk; E. Tziaferi; T. Tziaferi

    2008-01-01

    First results are presented from an analysis of data from the DRIFT-IIa and DRIFT-IIb directional dark matter detectors at Boulby Mine in which alpha particle tracks were reconstructed and used to characterise detector performance—an important step towards optimising directional technology. The drift velocity in DRIFT-IIa was 59.3±0.2(stat)±7.5(sys)ms-1 based on an analysis of naturally occurring alpha-emitting background. The drift velocity in

  16. Cytotoxic reaction and TNF-alpha response of macrophages to polyurethane particles.

    PubMed

    Ma, Nan; Petit, Alain; Yahia, L'Hocine; Huk, Olga L; Tabrizian, Maryam

    2002-01-01

    Their unique mechanical and biological properties make polyurethanes (PUs) ideal materials for many implantable devices. However, uncertain long-term biostability in the human physiological environment limits their extensive clinical applications. Chronic inflammatory response associated with macrophage activation has been suggested as a prime factor; although the mechanism of macrophage activation in response to biomaterial surfaces and debris is still unknown. The overall objective of this work was to study the response of macrophages to PU materials in vitro by measuring cell viability and activity. The studies were carried out using phagocytozable-size PU particles from three types of commercially-available PUs: Pellethane 2363 80ABA (PL); Tecothane TT2065 (TC65); and Tecothane TT2085 (TC85). These polymers posess the same generic composition but differ in the length of hard and soft segments, as revealed by the FTIR and NMR studies. The results showed that PU particles affected both viability and activity of J774 macrophages. The percentage of mortality ranged from 1 to 15% with 10-100 microg ml(-1) of particles after 24 and 48 h incubation. These three types of particles induced different mortality on the macrophages. Specifically, the mortality with PL particles was 1-4% (p > 0.05), while the mortality with TC85 particles was 2-10% (p < 0.05) and 4-15% with TC65 (p < 0.05). Conversely, these particles also affected cell proliferation. Cell numbers increased by 132 and 167% after 24 and 48 h incubation, respectively, without particles, whereas the cell numbers increased only 46 and 78% with TC65, 66 and 105% with TC85, and 67 and 110% with PL in the presence of 100 microg ml(-1) of particles for the respective incubation times. PU particles also increased TNF-alpha release from macrophage. After having been incubated for 24 h with 100 microg ml(-1) particles of TC65, TC85, and PL, macrophages release TNF-alpha 7.4, 5.2, and 4.1 times more than the control. In conclusion, PU particles had cytotoxic effects on J774 macrophage at high concentrations. The order of macrophage response for three types of particles was TC65 > TC85 > PL. PU particles' effect on macrophage viability and activity depends on the concentration of particles and their chemical composition, especially on the ratio of hard to soft segments. PMID:12102593

  17. Simulation of {alpha}-particle redistribution due to sawteeth on TFTR

    SciTech Connect

    Yi Zhao; White, R.B.

    1996-12-31

    In recent Deuterium-Tritium experiments on the Tokamak Fusion Test Reactor (TFTR), both the Pellet Charge Exchange (PCX) and the alpha Charge Exchange Recombination Spectroscopy ({alpha}-CHERS) diagnostics indicate that sawtooth oscillations can cause significant broadening of the fusion alpha radial density profile. The authors investigate this sawtooth mixing phenomenon by applying a Hamiltonian guiding center approach. A model of time evolution of the Kadomtsev-type sawtooth is constructed. The presence of more than one mode in the nonlinear stage of the sawtooth crash is necessary to cause significant broadening of the alpha density profile. Use of numerical equilibria allows us to perform detailed comparisons with TFTR experimental data. The results are in reasonable agreement with {alpha}-CHERS and show a broadening of alpha particles similar to that seen in PCX measurements.

  18. Fire hose instability driven by alpha particles in the solar wind

    NASA Astrophysics Data System (ADS)

    Matteini, Lorenzo; Hellinger, Petr; Schwartz, Steven J.; Landi, Simone

    2015-04-01

    We discuss the dynamics of fire hose parallel instability driven by anisotropic alpha particles in a plasma with typical solar wind composition (n? = 5%ne). We show, for the first time, the liner and nonlinear dynamics of the instability by means of hybrid numeric simulations, highlighting its dependence on the main plasma parameters, including the relative drift between the alphas and the main proton population. Our results confirm that the parallel fire hose instability can be efficiently excited by anisotropic distribution of the less abundant alpha particles, even when the rest of the plasma (electrons and protons) is Maxwellian. Moreover, our finding suggest that the dynamics driven by the alphas can also influence the properties of the protons. In particular the instability is found to significantly affect the evolution of the alpha-proton drift, constraining its final intensity to values smaller than the local Alfvén speed, as observed in the solar wind far from the Sun. When simulations with both species initially anisotropic are performed, we find a coexistence of the fire hose wave activity excited by both ions, leading to final stable configurations which reflect the marginal stability state of each species. As a consequence, when observed in the commonly used (?||,T?/T||) plane, alpha particles and protons are seen to saturate in different regions of the parameter space. This property is in very good agreement with recent solar wind in situ observations and strongly suggests that those instabilities play a role in regulating the anisotropy solar wind ions.

  19. Mechanics and multiple-particle tracking microheterogeneity of alpha-actinin-cross-linked actin filament networks.

    PubMed Central

    Tseng, Y; Wirtz, D

    2001-01-01

    Cell morphology is controlled by the actin cytoskeleton organization and mechanical properties, which are regulated by the available contents in actin and actin regulatory proteins. Using rheometry and the recently developed multiple-particle tracking method, we compare the mechanical properties and microheterogeneity of actin filament networks containing the F-actin cross-linking protein alpha-actinin. The elasticity of F-actin/alpha-actinin networks increases with actin concentration more rapidly for a fixed molar ratio of actin to alpha-actinin than in the absence of alpha-actinin, for networks of fixed alpha-actinin concentration and of fixed actin concentration, but more slowly than theoretically predicted for a homogeneous cross-linked semiflexible polymer network. These rheological measurements are complemented by multiple-particle tracking of fluorescent microspheres imbedded in the networks. The distribution of the mean squared displacements of these microspheres becomes progressively more asymmetric and wider for increasing concentration in alpha-actinin and, to a lesser extent, for increasing actin concentration, which suggests that F-actin networks become progressively heterogeneous for increasing protein content. This may explain the slower-than-predicted rise in elasticity of F-actin/alpha-actinin networks. Together these in vitro results suggest that actin and alpha-actinin provides the cell with an unsuspected range of regulatory pathways to modulate its cytoskeleton's micromechanics and local organization in vivo. PMID:11509377

  20. Gene expression profile of human lymphocytes exposed to (211)At alpha particles.

    PubMed

    Turtoi, A; Brown, I; Schläger, M; Schneeweiss, F H A

    2010-08-01

    In this study, the Whole Human Genome 44K DNA microarray assay was used for the first time to obtain gene expression profiles in human peripheral blood lymphocytes 2 h after exposure (in suspension) to 6.78 MeV mean energy alpha particles from extracellular (211)At. Lymphocytes were exposed to fluences of 0.3-9.6 x 10(6) alpha particles/cm(2) [corresponding to mean absorbed alpha-particle doses (D(alpha)) of 0.05-1.60 Gy] over 30 min. Significantly modulated expression was identified in 338 early-response genes. Up-regulated expression was evident in 183 early-response genes, while the remaining 155 were down-regulated. Over half of the up-regulated genes and 40% of the down-regulated genes had a known biological process related primarily to cell growth and maintenance and cell communication. Genes associated with cell death were found only in the up-regulated genes and those with development only in the down-regulated genes. Eight selected early-response genes that displayed a sustained up- or down-regulation (CD36, HSPA2, MS4A6A, NFIL3, IL1F9, IRX5, RASL11B and SULT1B1) were further validated in alpha-particle-irradiated lymphocytes of two human individuals using the TaqMan(R) RT-qPCR technique. The results confirmed the observed microarray gene expression patterns. The expression modulation profiles of IL1F9, IRX5, RASL11B and SULT1B1 genes demonstrated similar trends in the two individuals studied. However, no significant linear correlation between increasing relative gene expression and the alpha-particle dose was evident. The results suggest the possibility that a panel of genes that react to alpha-particle radiation does exist and that they merit further study in a greater number of individuals to determine their possible value regarding alpha-particle biodosimetry. PMID:20681779

  1. CURRENT DRIVE BY LOWER HYBRID WAVES IN THE PRESENCE OF ENERGETIC ALPHA PARTICLES

    E-print Network

    energetic reactor plasma and, if they do, the wave power may be absorbed by alpha particles rather than not penetrate into the centre of the more energetic reactor plasma, and, second, if they do, as pointed out, reactor plasma, because there are sufficient hot electrons at a distance from the plasma centre

  2. Boron compounds as a dominant source of alpha particles in semiconductor devices

    Microsoft Academic Search

    Robert Baumann; Tim Hossain; Shinya Murata; Hideki Kitagawa

    1995-01-01

    The interaction of cosmic ray neutrons and boron is demonstrated as the dominant source of alpha particles and other radiations in electronic devices utilizing borophosphosilicate glass (BPSG). A simple process modification is proposed to significantly reduce this intense source of ionizing radiation without compromising the reflow and passivation properties of BPSG.

  3. RADON AND PROGENY ALPHA-PARTICLE ENERGY ANALYSIS USING NUCLEAR TRACK METHODOLOGY

    SciTech Connect

    Espinosa Garcia, Guillermo [ORNL; Golzarri y Moreno, Dr. Jose Ignacio [Instituto de Fisica, Mexico; Bogard, James S [ORNL

    2008-01-01

    A preliminary procedure for alpha energy analysis of radon and progeny using Nuclear Track Methodology (NTM) is described in this paper. The method is based on the relationship between alpha-particle energies deposited in polycarbonate material (CR-39) and the track size developed after a well-established chemical etching process. Track geometry, defined by parameters such as major or minor diameters, track area and overall track length, is shown to correlate with alpha-particle energy over the range 6.00 MeV (218Po) to 7.69 MeV (214Po). Track features are measured and the data analyzed automatically using a digital imaging system and commercial PC software. Examination of particle track diameters in CR-39 exposed to environmental radon reveals a multi-modal distribution. Locations of the maxima in this distribution are highly correlated with alpha particle energies of radon daughters, and the distributions are sufficiently resolved to identify the radioisotopes. This method can be useful for estimating the radiation dose from indoor exposure to radon and its progeny.

  4. PPPL-3164 -Preprint Date: January 1996, UC-420 Alpha Particle Losses from Tokamak Fusion Test Reactor

    E-print Network

    Reactor Deuterium-Tritium Plasmas D. S. Darrow, S. J. Zweben, S. Batha*, R. V. Budny, C. E. Bush, Z. Chang. S. Medley, M. Murakami, M. Petrov¶, C. K. Phillips, M. H. Redi, E. Ruskov§, D. A. Spong, E. J on tokamak reactor viability, the loss of deuterium-tritium alpha particles from the Tokamak Fusion Test

  5. alpha-particle knock-on signature in the neutron emission of DT plasmas

    Microsoft Academic Search

    L. Ballabio; G. Gorini; J. Käautllne

    1997-01-01

    The fast alpha-particle kinetic effects in fusion plasmas of deuterium and tritium are studied in the perspective that they can give rise to minority populations of fast fuel ions. The resulting modification of the neutron emission spectrum is computed for a plasma in the state of steady thermonuclear burn of conditions similar to those envisaged for the planned ITER tokamak.

  6. Depleted uranium-catalyzed oxidative DNA damage: absence of significant alpha particle decay

    Microsoft Academic Search

    Alexandra C. Miller; Michael Stewart; Kia Brooks; Lin Shi; Natalie Page

    2002-01-01

    Depleted uranium (DU) is a dense heavy metal used primarily in military applications. Published data from our laboratory have demonstrated that DU exposure in vitro to immortalized human osteoblast cells (HOS) is both neoplastically transforming and genotoxic. DU possesses both a radiological (alpha particle) and a chemical (metal) component. Since DU has a low-specific activity in comparison to natural uranium,

  7. The new Athena alpha particle X-ray spectrometer for the Mars Exploration Rovers

    Microsoft Academic Search

    R. Rieder; R. Gellert; J. Brückner; G. Klingelhöfer; G. Dreibus; A. Yen; S. W. Squyres

    2003-01-01

    The new alpha particle X-ray spectrometer (APXS) is part of the Athena payload of the two Mars Exploration Rovers (MER). The APXS sensor head is attached to the turret of the instrument deployment device (IDD) of the rover. The APXS is a very light-weight instrument for determining the major and minor elemental composition of Martian soils, rocks, and other geological

  8. Differential Flow Between Solar Wind Protons and Alpha Particles: First WIND Observations

    E-print Network

    Richardson, John

    made using the SWE Faraday cup detectors on the WIND p spacecraft are reported. Some overall trends solar wind. e e SWE includes two Faraday cup detectors for measuring th nergy-per-charge spectrum of solar wind protons and alpha - u particles [Ogilvie et al., 1995]. The Faraday cups provide meas rements

  9. Environmental Radioactivity 60 (2002) 293305 Absorbed dose delivered by alpha particles

    E-print Network

    Yu, K.N.

    2002-01-01

    fraction of alpha particles in sensitive cells of the tracheobronchial tree obtained by NRC and ICRP are in good agreement with those obtained previously by NRC and ICRP66. Using the semi-analytical method by NRC and ICRP, respectively, have been satisfactorily reproduced. Using the tissue stopping power

  10. Low temperature alpha particle irradiation of a STAR1000 CMOS APS

    Microsoft Academic Search

    G. R. Hopkinson; A. Mohammadzadeh

    2007-01-01

    A STAR1000 CMOS active pixel sensor was irradiated with alpha particles at -130degC and dark current measurements were made at temperatures up to 25degC. Approximately 90% of dark current spikes were seen to anneal near room temperature. This implies that room temperature irradiations will not give a good estimate of on-orbit effects for cooled applications.

  11. Low Temperature Alpha Particle Irradiation of a STAR1000 CMOS APS

    Microsoft Academic Search

    G. R. Hopkinson; A. Mohammadzadeh

    2008-01-01

    A STAR1000 CMOS active pixel sensor was irradiated with alpha particles at -130deg C and dark current measurements were made at temperatures up to 25degC. Approximately 90% of dark current spikes were seen to anneal near room temperature. This implies that room temperature irradiations will not give a good estimate of on-orbit effects for cooled applications.

  12. BJT detector with FPGA-based read-out for alpha particle monitoring

    Microsoft Academic Search

    V. Tyzhnevyi; G.-F. Dalla Betta; L. Rovati; G. Verzellesi; N. Zorzi

    2011-01-01

    In this work we introduce a new prototype of readout electronics (ALPHADET), which was designed for an alpha-particle detection system based on a bipolar junction transistor (BJT) detector. The system uses an FPGA, which provides many advantages at the stage of prototyping and testing the detector. The main design and electrical features of the board are discussed in this paper,

  13. Anomalous energy loss distributions of alpha particles in heavily implanted thin aluminium films

    Microsoft Academic Search

    K. M. Barfoot; S. E. Donnelly; R. Werz; P. Rietveld

    1982-01-01

    Anomalous energy loss distributions of Gd alpha particles have been observed in heavily implanted thin aluminium films. It is surmised that thin film micro-wrinkling is responsible for the observed effect and that the novel technique of energy loss spectral analysis (ELSA) should be useful in studies of the topography of such films.

  14. Destabilization of low mode number Alfven modes in a tokamak by energetic or alpha particles

    SciTech Connect

    Tsang, K. T.; Sigmar, D. J.; Whitson, J. C.

    1980-12-01

    With the inclusion of finite Larmor radius effects in the shear Alfven eigenmode equation, the continuous Alfven spectrum, which has been extensively discussed in ideal magnetohydrodynamics, is removed. Neutrally stable, discrete radial eigenmodes appear in the absence of sources of free energy and dissipation. Alpha (or energetic) particle toroidal drifts destabilize these modes, provided the particles are faster than the Alfven speed. Although the electron Landu resonance contributes to damping, a stability study of the parametric variation of the energy and the density scale length of the energetic particles shows that modes with low radial mode numbers remain unstable in most cases. Since the alpha particles are concentrated in the center of the plasma, this drift-type instability suggests anomalous helium ash diffusion. Indeed, it is shown that stochasticity of alpha orbits due to the overlapping of radially neighboring Alfven resonances is induced at low amplitudes, e/sub i//sup approx./phi/T/sub i/ greater than or equal to 0.05, implying a diffusion coefficient D/sub r//sup ..cap alpha../ greater than or equal to 4.4 x 10/sup 3/cm/sup 2//s.

  15. Variation of the track etch rates of alpha-particle trajectory in PADC

    NASA Astrophysics Data System (ADS)

    Zaki, M. F.; Hegazy, T. M.; Seddik, U.; Morsy, A. A.

    2005-01-01

    The formation of etched tracks in solid-state nuclear track detectors is usually described by assuming an unequivocal correlation of the etch-rate ratio with the energy loss of charged particles. For alpha particles, this assumption could be verified within the scatter of the experimental data. In this article, the dependence of the depth (x) on the track etch rate (V-T) was determined experimentally by track length measurement. It is found that the track etch rate as a function of the depth within the detector follows the Bragg curve. The track etch rate has been found to be described by a generalization of the restricted energy loss, in good approximation along the trajectories of alpha particles.

  16. Fabrication of substrates with curvature for cell cultivation by alpha-particle irradiation and chemical etching of PADC films

    E-print Network

    Yu, K.N.

    . As an application, the present work studied mechanosensing of substrate curvature by epithelial cells (HeLa cellsFabrication of substrates with curvature for cell cultivation by alpha-particle irradiation online 16 February 2012 Keywords: Microfabrication Cell-culture substrates Alpha particles PADC Substrate

  17. Alpha Particle-Driven Toroidal Alfv en Eigenmodes in Tokamak Fusion Test Reactor Deuterium-Tritium Plasmas: Theory and

    E-print Network

    Alpha Particle-Driven Toroidal Alfv en Eigenmodes in Tokamak Fusion Test Reactor Deuterium-Tritium 26, 11 1984 Deuterium- Tritium plasmas are analyzed using the NOVA-K code C. Z. Cheng, Phys. Reports Deuterium-Tritium DT plasma, the fusion product alpha particles are born with an energy of 3:5 Me

  18. Studying effects of Magnolol on alpha-particle induced bystander effects using PADC-film based dishes

    E-print Network

    Yu, K.N.

    Studying effects of Magnolol on alpha-particle induced bystander effects using PADC-film based May 2009 Accepted 17 October 2009 Keywords: Bystander effect Alpha-particle CHO cells Magnolol PADC irradiated directly by ionizing radiation. In the present paper, the effects of Magnolol, an extract from

  19. Alpha particle induced DNA damage and repair in normal cultured thyrocytes of different proliferation status.

    PubMed

    Lyckesvärd, Madeleine Nordén; Delle, Ulla; Kahu, Helena; Lindegren, Sture; Jensen, Holger; Bäck, Tom; Swanpalmer, John; Elmroth, Kecke

    2014-07-01

    Childhood exposure to ionizing radiation increases the risk of developing thyroid cancer later in life and this is suggested to be due to higher proliferation of the young thyroid. The interest of using high-LET alpha particles from Astatine-211 ((211)At), concentrated in the thyroid by the same mechanism as (131)I [1], in cancer treatment has increased during recent years because of its high efficiency in inducing biological damage and beneficial dose distribution when compared to low-LET radiation. Most knowledge of the DNA damage response in thyroid is from studies using low-LET irradiation and much less is known of high-LET irradiation. In this paper we investigated the DNA damage response and biological consequences to photons from Cobolt-60 ((60)Co) and alpha particles from (211)At in normal primary thyrocytes of different cell cycle status. For both radiation qualities the intensity levels of ?H2AX decreased during the first 24h in both cycling and stationary cultures and complete repair was seen in all cultures but cycling cells exposed to (211)At. Compared to stationary cells alpha particles were more harmful for cycling cultures, an effect also seen at the pChk2 levels. Increasing ratios of micronuclei per cell nuclei were seen up to 1Gy (211)At. We found that primary thyrocytes were much more sensitive to alpha particle exposure compared with low-LET photons. Calculations of the relative biological effectiveness yielded higher RBE for cycling cells compared with stationary cultures at a modest level of damage, clearly demonstrating that cell cycle status influences the relative effectiveness of alpha particles. PMID:24769180

  20. Lung cancer risk from exposure to alpha particles and inhalation of other pollutants in rats

    SciTech Connect

    Burns, F.J.

    1990-01-01

    The goal of these experiments is to establish a quantitative correlation between early DNA damage and cancer incidence in a way that would be helpful for assessing the carcinogenic risk of radon alone or in combination with specific indoor pollutants. Rat tracheal epithelium has been exposed in vivo to {sup 210}Po alpha particles in the presence and absence of NO{sub 2} or cigarette smoke. The major accomplishments so far are: the design and implementation of a tracheal implant to simulate radon alpha particle exposure, the measurement of DNA breaks in a small 7.0 mm segment of the trachea exposed to external x-irradiation, the measurement of the rate of repair of the x-ray induced tracheal DNA strand breaks, the measurement of DNA strand breaks following inhalation of cigarette smoke or NO{sub 2}, the measurement of tracheal DNA stand breaks following exposure to high doses {sup 210}Po alpha particle radiation, the assessment of the amount of mucous in the goblet cells and in the underlying mucous glands. So far we have been unable to detect DNA strand breaks in the tracheal epithelium as a result of exposure to NO{sub 2} cigarette smoke or {sup 210}Po alpha particles. We have developed a simple artificial' trachea consisting of rat tracheal epithelial cells growing on a basement membrane coated millipore filter. Experiments are proposed to utilize these artificial tracheas to eliminate the potential interference of increased mucous secretion and/or inflammation that can significantly affect the radiation dose from the alpha particles. 61 refs., 17 figs.

  1. Neoclassical Simulations of Fusion Alpha Particles in Pellet Charge Exchange Experiments on the Tokamak Fusion Test Reactor

    SciTech Connect

    Batha, S.H.; Budny, R.V.; Darrow, D.S.; Levinton, F.M.; Redi, M.H.; et al

    1999-02-01

    Neoclassical simulations of alpha particle density profiles in high fusion power plasmas on the Tokamak Fusion Test Reactor (TFTR) [Phys. Plasmas 5 (1998) 1577] are found to be in good agreement with measurements of the alpha distribution function made with a sensitive active neutral particle diagnostic. The calculations are carried out in Hamiltonian magnetic coordinates with a fast, particle-following Monte Carlo code which includes the neoclassical transport processes, a recent first-principles model for stochastic ripple loss and collisional effects. New global loss and confinement domain calculations allow an estimate of the actual alpha particle densities measured with the pellet charge exchange diagnostic.

  2. Preferential energization of alpha particles in polar coronal holes at one solar radius above the photosphere

    NASA Astrophysics Data System (ADS)

    Chakravarty, Aniruddha; Bose, M.

    2015-04-01

    Heating of polar coronal holes (PCH) during solar minimum and acceleration of the fast solar wind issuing therefrom lack comprehensive theoretical understanding. Wave-particle interactions are considered to have crucial effects on the extreme properties of heavy ions in the collisionless region of the PCH. In this paper, we have presented a novel sensitivity analysis to investigate plasma heating by radio waves at lower hybrid (LH) frequencies. We have employed a three-fluid Maxwell model comprising electrons, protons, and ?-particles at around two solar radii heliocentric distance in the PCH and derived a dispersion relation as a 13th-order polynomial for the frequency. Our model provides indications of preferential heating of ?-particles in comparison with protons by means of LH instabilities. We have employed the electron velocity and spatial charge distribution as our basic study tools so as to show the effects of alpha-proton differential mass and differential perpendicular velocity on the preferential heating of ?-particles.

  3. Alpha particle transport in the presence of ballooning type electrostatic driftwaves

    NASA Astrophysics Data System (ADS)

    Nishimura, Y.; Huang, B.; Cheng, C. Z.

    2015-07-01

    Employing Hamiltonian mechanics, the transport of fusion born alpha particles in the presence of driftwave turbulence is investigated. An analytical turbulence model based on the toroidal drift eigenmode is employed for guiding center orbit-following calculations. It is shown that high energy particles are less susceptible to driftwave turbulence. The passing particle transport is due to overlapping of guiding center electric islands whose widths are inversely proportional to the square root of the parallel velocity. For trapped particles, through a coordinate transformation from the poloidal angle and the parallel velocity to the action-angle variables, the resonance between the bounce motion and the toroidal precession motion, which can cause secondary island formation in the phase space, is demonstrated.

  4. Ionization and scintillation response of high-pressure xenon gas to alpha particles

    NASA Astrophysics Data System (ADS)

    Álvarez, V.; Borges, F. I. G.; Cárcel, S.; Cebrián, S.; Cervera, A.; Conde, C. A. N.; Dafni, T.; Díaz, J.; Egorov, M.; Esteve, R.; Evtoukhovitch, P.; Fernandes, L. M. P.; Ferrario, P.; Ferreira, A. L.; Freitas, E. D. C.; Gehman, V. M.; Gil, A.; Goldschmidt, A.; Gómez, H.; Gómez-Cadenas, J. J.; González-Díaz, D.; Gutiérrez, R. M.; Hauptman, J.; Hernando Morata, J. A.; Herrera, D. C.; Irastorza, I. G.; Jinete, M. A.; Labarga, L.; Laing, A.; Liubarsky, I.; Lopes, J. A. M.; Lorca, D.; Losada, M.; Luzón, G.; Marí, A.; Martín-Albo, J.; Miller, T.; Moiseenko, A.; Monrabal, F.; Monteiro, C. M. B.; Mora, F. J.; Moutinho, L. M.; Muñoz Vidal, J.; Natal da Luz, H.; Navarro, G.; Nebot-Guinot, M.; Nygren, D.; Oliveira, C. A. B.; Palma, R.; Pérez, J.; Pérez Aparicio, J. L.; Renner, J.; Ripoll, L.; Rodríguez, A.; Rodríguez, J.; Santos, F. P.; dos Santos, J. M. F.; Seguí, L.; Serra, L.; Shuman, D.; Simón, A.; Sofka, C.; Sorel, M.; Toledo, J. F.; Tomás, A.; Torrent, J.; Tsamalaidze, Z.; Vázquez, D.; Veloso, J. F. C. A.; Webb, R.; White, J. T.; Yahlali, N.

    2013-05-01

    High-pressure xenon gas is an attractive detection medium for a variety of applications in fundamental and applied physics. In this paper we study the ionization and scintillation detection properties of xenon gas at 10 bar pressure. For this purpose, we use a source of alpha particles in the NEXT-DEMO time projection chamber, the large scale prototype of the NEXT-100 neutrinoless double beta decay experiment, in three different drift electric field configurations. We measure the ionization electron drift velocity and longitudinal diffusion, and compare our results to expectations based on available electron scattering cross sections on pure xenon. In addition, two types of measurements addressing the connection between the ionization and scintillation yields are performed. On the one hand we observe, for the first time in xenon gas, large event-by-event correlated fluctuations between the ionization and scintillation signals, similar to that already observed in liquid xenon. On the other hand, we study the field dependence of the average scintillation and ionization yields. Both types of measurements may shed light on the mechanism of electron-ion recombination in xenon gas for highly-ionizing particles. Finally, by comparing the response of alpha particles and electrons in NEXT-DEMO, we find no evidence for quenching of the primary scintillation light produced by alpha particles in the xenon gas.

  5. Alpha-particle-induced luminescence of rare-earth-doped Y 2O 3 nanophosphors

    NASA Astrophysics Data System (ADS)

    Cress, Cory D.; Redino, Christopher S.; Landi, Brian J.; Raffaelle, Ryne P.

    2008-08-01

    The feasibility of utilizing Y 2O 3:Tb 3+ and Y 2O 3:Eu 3+ as radioluminescent nanophosphors under alpha-particle excitation is investigated. Materials synthesized by the urea homogeneous precipitation method were characterized using scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray diffraction (XRD). The XRD analysis of as-produced precipitates and nanophosphors fired at temperatures ranging from 950 to 1100 °C indicated the presence of highly crystalline cubic Y 2O 3 with crystallite sizes of ˜40 nm. SEM and TEM analysis revealed that particles with average diameters of ˜200 nm and comprised of ˜40 nm grains were obtained. High-resolution radioluminescence and photoluminescence spectra were used to investigate the unwanted radioluminescence saturation effects associated with the high ionization rate of alpha-particles. Additionally, the radioluminescence intensity as a function of rare-earth ion dopant concentration is investigated for these materials under alpha-particle excitation. The prospect for utilizing these materials as intermediate absorbers in indirect-conversion radioisotope batteries is discussed.

  6. Acceleration of low-energy protons and alpha particles at interplanetary shock waves

    NASA Technical Reports Server (NTRS)

    Scholer, M.; Hovestadt, D.; Ipavich, F. M.; Gloeckler, G.

    1983-01-01

    The low-energy protons and alpha particles in the energy range 30 keV/charge to 150 keV/charge associated with three different interplanetary shock waves in the immediate preshock and postshock region are studied using data obtained by the ISEE 3. The spatial distributions in the preshock and postshock medium are presented, and the dependence of the phase space density at different energies on the distance from the shock and on the form of the distribution function of both species immediately at the shock is examined. It is found that in the preshock region the particles are flowing in the solar wind frame of reference away from the shock and in the postshock medium the distribution is more or less isotropic in this frame of reference. The distribution function in the postshock region can be represented by a power law in energy which has the same spectral exponent for both protons and alpha particles. It is concluded that the first-order Fermi acceleration process can consistently explain the data, although the spectra of diffuse bow shock associated particles are different from the spectra of the interplanetary shock-associated particles in the immediate vicinity of the shock. In addition, the mean free path of the low energy ions in the preshock medium is found to be considerably smaller than the mean free path determined by the turbulence of the background interplanetary medium.

  7. Coinhibition of viral interferon induction by Benzo(. alpha. )pyrene in association with occupation-related particles

    SciTech Connect

    Hahon, N. (National Inst. for Occupational Safety and Health, Morgantown, WV (United States) West Virginia Univ., Morgantown (United States)); Booth, J.A. (West Virginia Univ., Morgantown (United States)); Flowers, L. (Univ. of Pennsylvania, Philadelphia (United States))

    1990-06-01

    Benzo({alpha})pyrene (B(a)P) in combination with coal, asbestos, silicate, or metal particles was studied for its inhibitory effects on interferon-{alpha}/{beta} induction by influenza virus in rhesus monkey kidney (LLC-MK{sub 2}) cell monolayers. B(a)P per se had no adverse effect on the induction process. However, when cell cultures were pretreated with B(a)P that was bioactivated by rat liver S9 homogenate, from 52 to 65% inhibition of interferon induction occurred. Significantly greater depression (coinhibition) of viral interferon induction (>83%) resulted when bioactivated B(a)P was incorporated with coal particles representative of coal rank (anthracite, bituminous, lignite, peat). Coinhibition affected by bioactivated B(a)P was coal rank-independent but any interferon inhibitory activity affected by coal particles per se was coal rank-independent. When metals (aluminum, aluminum oxide, ferric oxide, nickel, or chromium) or asbestos fibers were individually mixed with bioactivated B(a)P, coinhibition of cellular interferon synthesis also resulted which was significantly greater than that manifested by bioactivated B(a)P or particles per se. Coinhibition of interferon induction by silicates and the bioactivated hydrocarbon was not in evidence although some silicates alone partially inhibited the induction process. Viral interferon induction was inhibited in a dose-response manner by B(a)P ({+-}S9) in combination with selected particles.

  8. Mutagenic effects of a single and an exact number of alpha particles in mammalian cells

    NASA Technical Reports Server (NTRS)

    Hei, T. K.; Wu, L. J.; Liu, S. X.; Vannais, D.; Waldren, C. A.; Randers-Pehrson, G.

    1997-01-01

    One of the main uncertainties in risk estimation for environmental radon exposure using lung cancer data from underground miners is the extrapolation from high- to low-dose exposure where multiple traversal is extremely rare. The biological effects of a single alpha particle are currently unknown. Using the recently available microbeam source at the Radiological Research Accelerator Facility at Columbia University, we examined the frequencies and molecular spectrum of S1- mutants induced in human-hamster hybrid (A(L)) cells by either a single or an exact number of alpha particles. Exponentially growing cells were stained briefly with a nontoxic concentration of Hoechst dye for image analysis, and the location of individual cells was computer-monitored. The nucleus of each cell was irradiated with either 1,2,4, or 8 alpha particles at a linear energy transfer of 90 keV/microm consistent with the energy spectrum of domestic radon exposure. Although single-particle traversal was only slightly cytotoxic to A(L) cells (survival fraction approximately 0.82), it was highly mutagenic, and the induced mutant fraction averaged 110 mutants per 10(5) survivors. In addition, both toxicity and mutant induction were dose-dependent. Multiplex PCR analysis of mutant DNA showed that the proportion of mutants with multilocus deletions increased with the number of particle traversals. These data provide direct evidence that a single a particle traversing a nucleus will have a high probability of resulting in a mutation and highlight the need for radiation protection at low doses.

  9. Electronic Properties of DNA-Based Schottky Barrier Diodes in Response to Alpha Particles.

    PubMed

    Al-Ta'ii, Hassan Maktuff Jaber; Periasamy, Vengadesh; Amin, Yusoff Mohd

    2015-01-01

    Detection of nuclear radiation such as alpha particles has become an important field of research in recent history due to nuclear threats and accidents. In this context; deoxyribonucleic acid (DNA) acting as an organic semiconducting material could be utilized in a metal/semiconductor Schottky junction for detecting alpha particles. In this work we demonstrate for the first time the effect of alpha irradiation on an Al/DNA/p-Si/Al Schottky diode by investigating its current-voltage characteristics. The diodes were exposed for different periods (0-20 min) of irradiation. Various diode parameters such as ideality factor, barrier height, series resistance, Richardson constant and saturation current were then determined using conventional, Cheung and Cheung's and Norde methods. Generally, ideality factor or n values were observed to be greater than unity, which indicates the influence of some other current transport mechanism besides thermionic processes. Results indicated ideality factor variation between 9.97 and 9.57 for irradiation times between the ranges 0 to 20 min. Increase in the series resistance with increase in irradiation time was also observed when calculated using conventional and Cheung and Cheung's methods. These responses demonstrate that changes in the electrical characteristics of the metal-semiconductor-metal diode could be further utilized as sensing elements to detect alpha particles. PMID:26007733

  10. Electronic Properties of DNA-Based Schottky Barrier Diodes in Response to Alpha Particles

    PubMed Central

    Al-Ta’ii, Hassan Maktuff Jaber; Periasamy, Vengadesh; Amin, Yusoff Mohd

    2015-01-01

    Detection of nuclear radiation such as alpha particles has become an important field of research in recent history due to nuclear threats and accidents. In this context; deoxyribonucleic acid (DNA) acting as an organic semiconducting material could be utilized in a metal/semiconductor Schottky junction for detecting alpha particles. In this work we demonstrate for the first time the effect of alpha irradiation on an Al/DNA/p-Si/Al Schottky diode by investigating its current-voltage characteristics. The diodes were exposed for different periods (0–20 min) of irradiation. Various diode parameters such as ideality factor, barrier height, series resistance, Richardson constant and saturation current were then determined using conventional, Cheung and Cheung’s and Norde methods. Generally, ideality factor or n values were observed to be greater than unity, which indicates the influence of some other current transport mechanism besides thermionic processes. Results indicated ideality factor variation between 9.97 and 9.57 for irradiation times between the ranges 0 to 20 min. Increase in the series resistance with increase in irradiation time was also observed when calculated using conventional and Cheung and Cheung’s methods. These responses demonstrate that changes in the electrical characteristics of the metal-semiconductor-metal diode could be further utilized as sensing elements to detect alpha particles. PMID:26007733

  11. Lost alpha-particle diagnostics from a D-T plasma by using nuclear reactions

    SciTech Connect

    Sasao, Mamiko [Organization for Research Initiative and Development, Doshisha University, Kyotanabe, Kyoto 610-0321 (Japan); Wada, Motoi [Graduate School of Science and Engineering, Doshisha University, Kyotanabe, Kyoto 610-0321 (Japan); Isobe, Mitsutaka [National Institute for Fusion Science, Toki Gifu 509-5292 (Japan)

    2014-08-21

    Among various methods proposed for alpha-particles loss measurement, we studied on those by measuring gamma rays of three cases, from (1) nuclear reactions induced by alpha particles, (2) those from short-life-time activities and (3) those from long-life-time activities induced by alpha particles. The time evolution of local alpha flux may possibly be measured by using the {sup 9}Be (a, n) {sup 12}C reaction (1). Using the same system, but with a target set up close to the first wall, activation measurement on site right after turning-off the discharge is possible (2). Nuclear reaction, {sup 25}Mg (a, p) {sup 28}Al, that produce radioisotopes of short lifetime of 2.2 minutes in one of the best candidates. As to the activation to a long lifetime (3), it is predicted that the gamma ray yield from {sup 19}F (a, n) {sup 22}Na reaction is enough for the measurement at the reactor site.

  12. Production of actinium-225 for alpha particle mediated radioimmunotherapy.

    PubMed

    Boll, Rose A; Malkemus, Dairin; Mirzadeh, Saed

    2005-05-01

    The initial clinical trials for treatment of acute myeloid leukemia have demonstrated the effectiveness of the alpha emitter (213)Bi in killing cancer cells. Bismuth-213 is obtained from a radionuclide generator system from decay of 10-days (225)Ac parent. Recent pre-clinical studies have also shown the potential application of both (213)Bi, and the (225)Ac parent radionuclide in a variety of cancer systems and targeted radiotherapy. This paper describes our five years of experience in production of (225)Ac in partial support of the on-going clinical trials. A four-step chemical process, consisting of both anion and cation exchange chromatography, is utilized for routine separation of carrier-free (225)Ac from a mixture of (228)Th, (229)Th and (232)Th. The separation of Ra and Ac from Th is achieved using the marcoporous anion exchange resin MP1 in 8M HNO(3) media. Two sequential MP1/NO(3) columns provide a separation factor of approximately 10(6) for Ra and Ac from Th. The separation of Ac from Ra is accomplished on a low cross-linking cation exchange resin AG50-X4 using 1.2M HNO(3) as eluant. Two sequential AG50/NO(3) columns provide a separation factor of approximately 10(2) for Ac from Ra. A 60-day processing schedule has been adopted in order to reduce the processing cost and to provide the highest levels of (225)Ac possible. Over an 8-week campaign, a total of approximately 100 mCi of (225)Ac (approximately 80% of the theoretical yield) is shipped in 5-6 batches, with the first batch typically consisting of approximately 50 mCi. After the initial separation and purification of Ac, the Ra pool is re-processed on a bi-weekly schedule or as needed to provide smaller batches of (225)Ac. The averaged radioisotopic purity of the (225)Ac was 99.6 +/- 0.7% with a (225)Ra content of < or =0.6%, and an average (229)Th content of (4(-4)(+5)) x 10(-5)%. PMID:15763472

  13. Wurtzite Gallium Nitride as a scintillator detector for alpha particles (a Geant4 simulation)

    NASA Astrophysics Data System (ADS)

    Taheri, A.; Sheidaiy, M.

    2015-05-01

    Gallium Nitride has become a very popular material in electronics and optoelectronics. Because of its interesting properties, it is suitable for a large range of applications. This material also shows very good scintillation properties that make it a possible candidate for use as a charged particles scintillator detector. In this work, we simulated the scintillation and optical properties of the gallium nitride in the presence of alpha particles using Geant4. The results show that gallium nitride can be an appropriate choice for this purpose.

  14. Skeletal dosimetry models for alpha-particles for use in molecular radiotherapy

    NASA Astrophysics Data System (ADS)

    Watchman, Christopher J.

    Molecular radiotherapy is a cancer treatment methodology whereby a radionuclide is combined with a biologically active molecule to preferentially target cancer cells. Alpha-particle emitting radionuclides show significant potential for use in molecular radiotherapy due to the short range of the alpha-particles in tissue and their high rates of energy deposition. Current radiation dosimetry models used to assess alpha emitter dose in the skeleton were developed originally for occupational applications. In medical dosimetry, individual variability in uptake, translocation and other biological factors can result in poor correlation of clinical outcome with marrow dose estimates determined using existing skeletal models. Methods presented in this work were developed in response to the need for dosimetry models which account for these biological and patient-specific factors. Dosimetry models are presented for trabecular bone alpha particle dosimetry as well as a model for cortical bone dosimetry. These radiation transport models are the 3D chord-based infinite spongiosa transport model (3D-CBIST) and the chord-based infinite cortical transport model (CBICT), respectively. Absorbed fraction data for several skeletal tissues for several subjects are presented. Each modeling strategy accounts for biological parameters, such as bone marrow cellularity, not previously incorporated into alpha-particle skeletal dosimetry models used in radiation protection. Using these data a study investigating the variability in alpha-particle absorbed fractions in the human skeleton is also presented. Data is also offered relating skeletal tissue masses in individual bone sites for a range of ages. These data are necessary for dose calculations and have previously only been available as whole body tissue masses. A revised 3D-CBIST model is also presented which allows for changes in endosteum thickness to account for revised target cell location of tissues involved in the radiological induction of bone cancer. In addition, new data are presented on the location of bone-marrow stem cells within the marrow cavities of trabecular bone of the pelvis. All results presented in this work may be applied to occupational exposures, but their greatest utility lies in dose assessments for alpha-emitters in molecular radiotherapy.

  15. Survival and yields of chromosome aberrations in hamster and human lung cells irradiated by alpha particles

    SciTech Connect

    Simmons, J.A.; Cohn, P.; Min, T. [Univ. of Westminster, London (United Kingdom)

    1996-02-01

    The effects of {alpha}-particle irradiation on hamster and human lung cells have been studied. In both cases two end points were taken, cell death and the induction of chromosome aberrations. The hamster cells were common stock V79 cells; the human ones were freshly derived from fetal material. For both types of cells, the survival curves could be described by straight lines in the conventional exponential plot, with values of D{sub 0} of 0.78 and 0.37 Gy for the hamster and human cells, respectively. The rate of induction of chromosome aberrations could also be described by straight lines with slopes of 0.30 and 0.62 aberration per cell per gray. Thus, for this second end point also, it appears that human cells are twice as sensitive to the effects of {alpha}-particle irradiation as hamster cells. 30 refs., 3 figs., 2 tabs.

  16. Targeted alpha-particle radiotherapy with 211At-labeled monoclonal antibodies.

    PubMed

    Zalutsky, Michael R; Reardon, David A; Pozzi, Oscar R; Vaidyanathan, Ganesan; Bigner, Darell D

    2007-10-01

    An attractive feature of targeted radionuclide therapy is the ability to select radionuclides and targeting vehicles with characteristics that are best suited for a particular clinical application. One combination that has been receiving increasing attention is the use of monoclonal antibodies (mAbs) specifically reactive to receptors and antigens that are expressed in tumor cells to selectively deliver the alpha-particle-emitting radiohalogen astatine-211 (211At) to malignant cell populations. Promising results have been obtained in preclinical models with multiple 211At-labeled mAbs; however, translation of the concept to the clinic has been slow. Impediments to this process include limited radionuclide availability, the need for suitable radiochemistry methods operant at high activity levels and lack of data concerning the toxicity of alpha-particle emitters in humans. Nonetheless, two clinical trials have been initiated to date with 211At-labeled mAbs, and others are planned for the near future. PMID:17921029

  17. Determination of the range of alpha particles in histological samples using a proton beam

    Microsoft Academic Search

    M Giacomelli; J Skvar?; R Ili?

    2001-01-01

    The 70?m-thick sliced mouse samples used in boron neutron capture therapy research are normally freeze-dried and permanently mounted on a sticky tape. Such a preparation alters the tissue density and makes it impossible to correctly determine the ranges of the alpha particles from the 10B(n,?)7Li reaction. Proton radiography utilising etched-track detectors can be successfully used for the density determination of

  18. Ionisation cross sections of Cd, Sn, Te, I and Ba for protons and alpha particles

    Microsoft Academic Search

    L. Avaldi; M. Milazzo; G. Trivia; I. V. Mitchell

    1983-01-01

    K-shell X-ray production cross sections of 48Cd, 50Sn, 52Te, 53I and 56Ba have been measured for alpha particles with energies between 2.2 and 2.8 MeV. In addition, production cross sections for 52Te have been measured for protons between 1.6 and 3 MeV. The values have been compared with the earlier experiments and with the theoretical predictions given by four different

  19. Choosing fitting functions to describe peak tails in alpha-particle spectrometry

    Microsoft Academic Search

    C. John Bland

    1998-01-01

    We seek to identify the major differences between two types of peak-fitting programs for alpha-particle spectrometry. One function is the well-known convolution of a Gaussian function with two (usually) left-handed exponential functions. The other function is contained in an analysis program described by Koskelo et al. (Koskelo, M. J., Burnett, W. C. and Cable, P. H. (1996) An advanced analysis

  20. Alpha-Particle-Driven Toroidal Alfvén Eigenmodes in the Tokamak Fusion Test Reactor

    Microsoft Academic Search

    R. Nazikian; G. Y. Fu; S. H. Batha; M. G. Bell; R. E. Bell; R. V. Budny; C. E. Bush; Z. Chang; Y. Chen; C. Z. Cheng; D. S. Darrow; P. C. Efthimion; E. D. Fredrickson; N. N. Gorelenkov; B. Leblanc; F. M. Levinton; R. Majeski; E. Mazzucato; S. S. Medley; H. K. Park; M. P. Petrov; D. A. Spong; J. D. Strachan; E. J. Synakowski; G. Taylor; S. von Goeler; R. B. White; K. L. Wong; S. J. Zweben

    1997-01-01

    Alpha-particle-driven toroidal Alfvén eigenmodes (TAEs) have been observed for the first time in deuterium-tritium (D-T) plasmas on the tokamak fusion test reactor (TFTR). These modes are observed 100-200 ms following the end of neutral beam injection in plasmas with reduced central magnetic shear and elevated central safety factor [q0>1]. Mode activity is localized to the central region of the discharge

  1. GaN as a detector of alpha-particles and neutrons

    Microsoft Academic Search

    A. Y. Polyakov; N. B. Smirnov; A. V. Govorkov; In-Hwan Lee; S. J. Pearton; N. G. Kolin; I. L. Gazizov; V. M. Zalyetin

    2011-01-01

    Properties of GaN radiation detectors are analyzed. It is shown that present day epitaxial material is suitable for detection of alpha-particles with the charge collection efficiency close to 100%. Such detectors can operate at temperatures of at least 60°C and withstand irradiation with reactor neutrons fluences higher than 1015 cm-2. They keep the collection efficiency at 30% even after irradiation

  2. Study of the beta-delayed alpha-particle emission of [sup 16]N

    Microsoft Academic Search

    Z. Zhao; R. H. France; K. S. Lai; M. Gai; E. L. Wilds; R. A. Kryger; J. A. Winger; K. B. Beard

    1993-01-01

    The beta-delayed alpha-particle emission of [sup 16]N has been studied, with [sup 16]N nuclei produced using 80 MeV\\/nucleon [sup 18]O beams on [sup 9]Be targets. The [sup 16]N secondary nuclei were mass analyzed and separated from the reaction products using the Michigan State University A1200 isotope separator. A detector array, including four thin surface barrier detectors, a [ital p]-[ital i]-[ital

  3. Study of the beta-delayed alpha-particle emission of 16N

    Microsoft Academic Search

    Z. Zhao; R. H. France III; K. S. Lai; M. Gai; E. L. Wilds; R. A. Kryger; J. A. Winger; K. B. Beard

    1993-01-01

    The beta-delayed alpha-particle emission of 16N has been studied, with 16N nuclei produced using 80 MeV\\/nucleon 18O beams on 9Be targets. The 16N secondary nuclei were mass analyzed and separated from the reaction products using the Michigan State University A1200 isotope separator. A detector array, including four thin surface barrier detectors, a p-i-n diode, a Ge gamma-ray detector, and a

  4. Fusion alpha-particle losses in a high-beta rippled tokamak

    SciTech Connect

    Bunno, M.; Nakamura, Y. [Graduate School of Energy Science, Kyoto University, Gokasho, Uji, Kyoto 611-0011 (Japan)] [Graduate School of Energy Science, Kyoto University, Gokasho, Uji, Kyoto 611-0011 (Japan); Suzuki, Y. [National Institute for Fusion Science, Toki 509-5292 (Japan)] [National Institute for Fusion Science, Toki 509-5292 (Japan); Shinohara, K.; Matsunaga, G. [Japan Atomic Energy Agency, Naka, Ibaraki 311-0193 (Japan)] [Japan Atomic Energy Agency, Naka, Ibaraki 311-0193 (Japan); Tani, K. [Nippon Advanced Technology, Naka, Ibaraki 311-0102 (Japan)] [Nippon Advanced Technology, Naka, Ibaraki 311-0102 (Japan)

    2013-08-15

    In tokamak plasmas, the confinement of energetic ions depends on the magnetic field structure. If the plasma pressure is finite, the equilibrium current (i.e., the Pfirsch-Schlüter current and diamagnetic current) flows in the plasma to maintain the magnetohydrodynamic (MHD) equilibrium. These plasma currents generate poloidal and toroidal magnetic field and alter the field structure. Moreover, if we consider the non-axisymmetry of magnetic field structures such as toroidal field (TF) ripples, the non-axisymmetric component of the equilibrium current can alter TF ripples themselves. When the plasma beta becomes high, the changes in the field structure due to the equilibrium current might affect the confinement of energetic ions significantly. We intend to clarify how these currents alter the field structure and affect the confinement of alpha particles in high-beta plasma. The MHD equilibrium is calculated using VMEC and the orbits of fusion alpha particles are followed by using the fully three-dimensional magnetic field orbit-following Monte Carlo code. In relatively low-beta plasma (e.g., the volume-averaged beta value ?2%), the changes in the magnetic field component due to the plasma current negligibly affect the confinement of alpha particles except for the Shafranov shift effect. However, for ?3%, the diamagnetic effect reduces the magnetic field strength and significantly increases alpha-particle losses. In these high-beta cases, the non-axisymmetric field component generated by the equilibrium current also increases these losses, but not as effectively as compared to the diamagnetic effect.

  5. Accuracy testing using thick source alpha-particle spectroscopy for the U and Th series estimations.

    PubMed

    Michael, C T; Zacharias, N; Hein, A

    2010-01-01

    The new technique for the calculation of U and Th based on the alpha particle spectrum taken from a thick sample by using a silicon detector (PIPS) is tested and some technical problems are encountered and also some notifications for better accuracy are addressed. This technique which is mainly developed to be used for dose rate determination in TL, OSL and ESR dating applications, gives also the possibility for detecting and estimating possible disequilibrium in U and Th series. PMID:19900816

  6. Quantum 1/f noise in nondegenerate semiconductors and emission statistics of alpha particles

    SciTech Connect

    Kousik, G.S.

    1985-01-01

    Charged particle scattering is accompanied by the emission of soft photons. Handel's theory of 1/f noise, based on the infrared divergent coupling of the system to the electromagnetic field or other elementary excitations, states that the current associated with a beam of scattered particles will exhibit 1/f noise. The fraction of the particles scattered with an energy loss epsilon to soft photon emission is proportional to 1/epsilon and herein lies the origin of the quantum theory of 1/f noise. The 1/f noise caused by mobility fluctuations in semiconductors is related to the scattering cross section fluctuation given by Handel's theory, through the relaxation time. Results are presented of the detailed calculation of mobility fluctuation 1/f noise and Hooge parameter in nondegenerate semiconductors. Numerical results are given for silicon and gallium arsenide. Data obtained from extensive measurements on counting techniques for alpha-particle radioactive decay from a source containing /sub 94/Pu/sup 239/, /sub 95/Am/sup 241/ and /sub 96/Cm/sup 244/ are presented. These data show that the statistics are non-Poissonian for large counting times (of the order of 1000 minutes) contrary to the popular belief that alpha decay is an example of Poissonian statistics.

  7. Malignant transformation of human benign prostate epithelial cells by high linear energy transfer alpha-particles.

    PubMed

    Li, Hongzhen; Gu, Yongpeng; Miki, Jun; Hukku, Bharati; McLeod, David G; Hei, Tom K; Rhim, Johng S

    2007-09-01

    Although epidemiological studies have suggested a positive correlation between environmental radon exposure and prostate cancer, the mechanism involved is not clear. In the present study, we examined the oncogenic transforming potency of alpha-particles using non-tumorigenic, telomerase-immortalized human benign prostate epithelial cells. We report the malignant transformation of human benign prostate epithelial cells after a single exposure to 0.6 Gy dose of alpha-particles. Transformed cells showed anchorage-independent growth in soft agar and induced progressively growing tumors when transplanted into SCID mice. The tumors were characterized histologically as poorly differentiated adenocarcinomas. The cell line derived from tumor (SCID 5015), like the unirradiated cells, expressed cytokeratin 5, 8 and 18, NKX3.1 and AMACR. The malignant cells showed increased secretion of MMP2. Stepwise chromosomal changes in the progression to tumorigenicity were observed. Chromosome abnormalities were identified in both irradiated and tumorigenic cells relative to the non-irradiated control cells. Prominent changes in chromosomes 6, 11 and 16, as well as mutations and deletions of the p53 gene were observed in the tumor outgrowth and tumor cells. These findings provide the first evidence of malignant transformation of human benign prostate epithelial cells exposed to a single dose of alpha-particles. This model provides an opportunity to study the cellular and molecular alterations that occur in radiation carcinogenesis in human prostate cells. PMID:17671680

  8. Hormetic effect induced by alpha-particle-induced stress communicated in vivo between zebrafish embryos.

    PubMed

    Choi, V W Y; Cheung, A L Y; Cheng, S H; Yu, K N

    2012-11-01

    We report data showing that embryos of the zebrafish, Danio rerio, at 1.5 h post fertilization (hpf) subjected to a low-dose alpha-particle irradiation can release a stress signal into the water, which can be communicated to unirradiated bystander zebrafish embryos sharing the same water medium to induce a hormetic effect in the bystander embryos. Hormetic responses are characterized as biphasic dose-response relationships exhibiting a low-dose stimulation and a high-dose inhibition. The effects on the whole embryos were studied through quantification of apoptotic signals at 24 hpf through staining with the vital dye acridine orange, followed by counting the stained cells under a microscope. The results show that, for low alpha-particle dose, the number of apoptotic signals decreases in the irradiated embryos and also in the unirradiated bystander embryos having partnered with the irradiated embryos. These suggested that alpha-particle-irradiated zebrafish embryos could release a stress signal into the water, which could be communicated to unirradiated bystander zebrafish embryos sharing the same water medium to induce a hormetic effect in the bystander embryos. PMID:23050846

  9. Study of the beta-delayed alpha-particle emission of 16N

    NASA Astrophysics Data System (ADS)

    Zhao, Z.; France, R. H., III; Lai, K. S.; Gai, M.; Wilds, E. L.; Kryger, R. A.; Winger, J. A.; Beard, K. B.

    1993-07-01

    The beta-delayed alpha-particle emission of 16N has been studied, with 16N nuclei produced using 80 MeV/nucleon 18O beams on 9Be targets. The 16N secondary nuclei were mass analyzed and separated from the reaction products using the Michigan State University A1200 isotope separator. A detector array, including four thin surface barrier detectors, a p-i-n diode, a Ge gamma-ray detector, and a two-dimensional position sensitive parallel plate avalanche counter, was used for implantation and study of the separated nuclei. A beta-decay branching ratio of (1.3+/-0.3)×10-5 to the 1- state at 9.6 MeV and a centroid of 2.35+/-0.05 MeV for the beta-delayed alpha-particle emission were measured. These results are essential for the analysis of a high sensitivity measurement at Yale University of the low-energy beta-delayed alpha-particle emission of 16N, and for understanding the 12C(?,?)16O reaction in the helium burning process in massive stars.

  10. Electrostatic ion-acoustic-like instabilities in the solar wind with a backstreaming alpha particle beam

    SciTech Connect

    Gomberoff, L. [Departamento de Fisica, Facultad de Ciencias, Universidad de Chile, Santiago (Chile); Gomberoff, K. [Department of Physics, Technion, Haifa 32000 (Israel); Deutsch, A. [Rafael, P.O. Box 2250, Haifa 31021 (Israel)

    2010-06-15

    Nonlinear electrostatic instabilities have been shown to occur frequently and under very different conditions in plasma with two ion beams such as the fast solar wind. These instabilities can be triggered when the phase velocity of electrostatic ion-acoustic waves propagating forward and backward relative to the interplanetary magnetic field overlaps due to the presence of a finite amplitude of circularly polarized wave. The instabilities can be triggered by waves supported by the same ion component, or by waves supported by different ion components. By assuming a beam of alpha particles moving backward relative to the external magnetic field, as observed in some events in the fast solar wind, it is shown that a very small negative drift velocity of the alpha particle beam relative to the core plasma--a few percent of the local Alfven velocity--can trigger a very rich variety of nonlinear electrostatic acousticlike instabilities. Their growth rates can be rather large and they persist for larger negative alpha particles drift velocities and temperatures.

  11. Cryogenic microcalorimeter system for ultra-high resolution alpha-particle spectrometry

    SciTech Connect

    Rabin, Michael W [Los Alamos National Laboratory; Hoover, Andrew S [Los Alamos National Laboratory; Bacrania, Mnesh K [Los Alamos National Laboratory; Croce, Mark P [Los Alamos National Laboratory; Hoteling, N J [Los Alamos National Laboratory; Lamont, S P [Los Alamos National Laboratory; Plionis, A A [Los Alamos National Laboratory; Dry, D E [Los Alamos National Laboratory; Ullom, J N [NIST; Bennett, D A [NIST; Horansky, R [NIST; Kotsubo, V [NIST; Cantor, R [STAR CRYOELECTRONICS

    2009-01-01

    Microcalorimeters have been shown to yield unsurpassed energy resolution for alpha spectrometry, up to 1.06 keV FWHM at 5.3 MeV. These detectors use a superconducting transition-edge sensor (TES) to measure the temperature change in an absorber from energy deposited by an interacting alpha particle. Our system has four independent detectors mounted inside a liquid nitrogen/liquid helium cryostat. An adiabatic demagnetization refrigerator (ADR) cools the detector stage to its operating temperature of 80 mK. Temperature regulation with {approx}15 uK peak-to-peak variation is achieved by PID control of the ADR. The detectors are voltage-biased, and the current signal is amplified by a commercial SQUID readout system and digitized for further analysis, This paper will discuss design and operation of our microcalorimeter alpha spectrometer, and will show recent results.

  12. Beams of protons and alpha particles greater than approximately 30 keV/charge from the earth's bow shock

    NASA Technical Reports Server (NTRS)

    Scholer, M.; Ipavich, F. M.; Gloeckler, G.

    1981-01-01

    Two beamlike particle events (30 keV/charge to 160 keV/charge) upstream of the earth's bow shock have been investigated with the Max-Planck-Institut/University of Maryland ultralow energy and charge analyzer on ISEE 1. These beams consist of protons as well as of alpha particles, and the spectra are generally steep and are decreasing with increasing energy. During one event the spectra of both protons and alpha particles have a maximum at approximately 65 keV/charge. During these events, the interplanetary magnetic field through the satellite position was almost tangent to the bow shock, and application of the theory of acceleration predicts acceleration of a solar wind particle up to 60 keV/nucleon in a single reflection. The observation of reflected protons as well as alpha particles has implications for the physical reflection process usually not discussed in acceleration theories.

  13. Effects of alpha particles on the angular momentum loss from the Sun

    E-print Network

    Bo Li; Xing Li

    2006-06-07

    The classic Weber-Davis model of the solar wind is reconsidered by incorporating alpha particles and by allowing the solar wind to flow out of the equatorial plane in an axisymmetrical configuration. In the ion momentum equations of the solar wind, the ion gyro-frequency is many orders of magnitude higher than any other frequency. This requires that the difference between proton and alpha velocity vectors be aligned with the background magnetic field. With the aid of this alignment condition, the governing equations of the multi-fluid solar wind are derived from the standard transport equations. The governing equations are numerically solved along a prescribed meridional magnetic field line located at colatitude $70^\\circ$ at 1AU and a steady state fast solar wind solution is found. A general analysis concludes, in agreement with the Weber-Davis model, that the magnetic field helps the coronal plasma to achieve an effective corotation out to the Alfv\\'enic radius, where the poloidal Alfv\\'enic Mach number $M_T$ equals unity ($M_T$ is defined by equation (\\ref{eq:mach})). The model computations show that, magnetic stresses predominate the angular momentum loss of the Sun. For the fast wind considered, the proton contribution to the angular momentum loss, which can be larger than the magnetic one, is almost completely canceled by the alpha particles that develop an azimuthal speed in the direction opposite to the solar rotation. The Poynting flux associated with the azimuthal components is negligible in the energy budget. However, the solar rotation can play some role in reducing the relative speed between alpha particles and protons for low latitude fast solar wind streams in interplanetary space.

  14. Exciton dynamics in alpha-particle tracks in organic crystals: Magnetic field study of the scintillation in tetracene crystals

    Microsoft Academic Search

    Nicholas E. Geacintov; Michael Binder; Charles E. Swenberg; Martin Pope

    1975-01-01

    The mechanisms of scintillation of organic crystals bombarded by alpha particles are discussed in terms of the current knowledge of exciton dynamics, which has been derived from a study of the photofluorescence of crystals such as anthracene and tetracene. The scintillation of tetracene excited by 4.4-MeV alpha particles incident in a direction perpendicular to the ab plane has been studied

  15. Deep level defects and carrier removal due to proton and alpha particle irradiation of InP

    Microsoft Academic Search

    George C. Rybicki; Christian A. Zorman

    1994-01-01

    Deep level transient spectroscopy and capacitance voltage measurements of the defect introduction rates and carrier removal rates for 2 MeV proton and 2 MeV alpha particle irradiations in p-type InP have been performed. The carrier removal rate for 2 MeV protons was 6500 cm?1 and for 2 MeV alpha particles was 73 400 cm?1, or 12 times higher. The defect

  16. Comparitive Ionization Energies for Protons, Deuterons and Alpha Particles in High Purity Germanium and Si(Li) Nuclear Radiation Detectors

    Microsoft Academic Search

    M. Martini; T. W. Raudorf; W. R. Stott; J. C. Waddington

    1975-01-01

    Relative measurements of the average energy, ¿, expended for electron-hole pair generation in silicon and high purity germanium detectors were made using 10 to 19 MeV proton, deuteron and alpha particle beams. The results show that ¿ is constant for different particles in high purity germanium detectors but not in silicon detectors. A model is presented which could explain both

  17. Scattering of 42 MeV alpha particles from copper-65

    NASA Technical Reports Server (NTRS)

    Stewart, W. M.; Seth, K. K.

    1973-01-01

    Beams of 42-MeV alpha particles were elastically and inelastically scattered from Cu-65 in an attempt to excite states which may be described in terms of an excited core model. Angular distributions were measured for 17 excited states. Seven of the excited states had angular distributions similar to a core quadrupole excitation and eight of the excited states had angular distributions similar to a core octupole excitation. The excited state at 2.858 MeV had an angular distribution which suggests that it may have results from the particle coupling to a two-phonon core state. An extended particle-core coupling calculation was performed and the predicted energy levels and reduced transition probabilities compared to the experimental data. The low lying levels are described quite well and the wavefunctions of these states explain the large spectroscopic factors measured in stripping reactions. For Cu-65 the coupling of the particle to the core is no larger weak as in the simpler model, and configuration mixing results.

  18. Differential Effects of Alpha-Particle Radiation and X-Irradiation on Genes Associated with Apoptosis

    PubMed Central

    Chauhan, Vinita; Howland, Matthew; Chen, Jeremy; Kutzner, Barbara; Wilkins, Ruth C.

    2011-01-01

    This study examined differential effects of alpha-(?-) particle radiation and X-rays on apoptosis and associated changes in gene expression. Human monocytic cells were exposed to ?-particle radiation and X-rays from 0 to 1.5?Gy. Four days postexposure, cell death was measured by flow cytometry and 84 genes related to apoptosis were analyzed using real-time PCR. On average, 33% of the cells were apoptotic at 1.5?Gy of ?-particle radiation. Transcript profiling showed statistical expression of 15 genes at all three doses tested. Cells exposed to X-rays were <5% apoptotic at ~1.5?Gy and induced less than a 2-fold expression in 6 apoptotic genes at the higher doses of radiation. Among these 6 genes, Fas and TNF-? were common to the ?-irradiated cells. This data suggests that ?-particle radiation initiates cell death by TNF-? and Fas activation and through intermediate signalling mediators that are distinct from X-irradiated cells. PMID:22091383

  19. Alpha particle beam interactions with Fe-based FeCo-based amorphous magnets

    SciTech Connect

    Sorescu, M. [Duquesne Univ., Pittsburgh, PA (United States). Physics Dept.; Barb, D. [Inst. of Atomic Physics, Bucharest-Magurele (Romania)

    1997-12-01

    Samples of Fe{sub 78}B{sub 13}Si{sub 9} and Fe{sub 66}Co{sub 18}B{sub 15}Si{sub 1} metallic glasses were irradiated with alpha particle beams (W = 2.8 MeV) using radiation doses of 10{sup 16} and 10{sup 17} cm{sup {minus}2}. Irradiation-induced effects on the magnetic and structural properties of alloy samples were studied by transmission and conversion electron Moessbauer spectroscopy. The evolution of phases and microstructure during the radiation-induced amorphous-to-crystalline transformation was found to depend on the particle flux and sample composition. Differences between bulk and surface irradiation behaviors were demonstrated.

  20. Quantum 1/f noise in non-degerate semiconductors and emission statistics of alpha particles

    SciTech Connect

    Kousik, G.S.

    1985-01-01

    Charged particle scattering is accompanied by the emission of soft photons. Handel's theory of 1/f noise, based on the infrared divergent coupling of the system to the electromagnetic field or other elementary excitations, states that the current associated with a beam of scattered particles will exhibit 1/f noise. The fraction of the particles scattered with an energy loss epsilon to soft photon emission is proportional to 1/epsilon and herein lies the origin of the quantum theory of 1/f noise. The 1/f noise caused by mobility fluctuations in semiconductors is related to the scattering cross section fluctuation given by Handel's theory, through the relaxation time. Chapters Two through Five of this dissertation presents the results of the detailed calculation of mobility fluctuation 1/f noise and Hooge parameter in nondegenerate semiconductors. Numerical results are given for silicon and gallium arsenide. Data obtained from extensive measurements on counting techniques for alpha-particles radioactive decay from a source containing /sub 94/Pu/sup 239/, /sub 95/Am/sup 241/ and /sub 96/Cm/sup 244/ are presented in Chapters Six and Seven of this dissertation. These data show that the statistics are non-Poissonian for large counting times (of the order of 1000 minutes) contrary to the popular belief that alpha-decay is an example of Poissonian statistics. Measurements of the Allan variance indicated the presence of a slow Lorentzian flicker noise and 1/f noise and the magnitude of the noise for large counting times is considerably larger than that predicted by Poissonian statistics.

  1. Chemistry of Rocks and Soils in Gusev Crater from the Alpha Particle X-ray Spectrometer

    NASA Technical Reports Server (NTRS)

    Gellert, R.; Rieder, R.; Anderson, R. C.; Brueckner, J.; Clark, B. C.; Dreibus, G.; Economou, T.; Klingelhoefer, G.; Lugmair, G. W.; Ming, D. W.

    2005-01-01

    The alpha particle x-ray spectrometer on the Spirit rover determined major and minor elements of soils and rocks in Gusev crater in order to unravel the crustal evolution of planet Mars. The composition of soils is similar to those at previous landing sites, as a result of global mixing and distribution by dust storms. Rocks (fresh surfaces exposed by the rock abrasion tool) resemble volcanic rocks of primitive basaltic composition with low intrinsic potassium contents. High abundance of bromine (up to 170 parts per million) in rocks may indicate the alteration of surfaces formed during a past period of aqueous activity in Gusev crater.

  2. Damage of EUV optical coatings induced by alpha-particles bombardment

    NASA Astrophysics Data System (ADS)

    Pelizzo, M. G.; Zuccon, S.; Napolitani, E.; Corso, A. J.; Zuppella, P.; Tessarolo, E.; Nardello, M.; Gerlin, F.; Naletto, G.; Fineschi, S.; Antonucci, E.

    2014-09-01

    Future solar missions will investigate the Sun from very close distances and optical components are constantly exposed to low energy ions irradiation. Single layer thin films as well as extreme ultraviolet multilayer coatings have been exposed to low energy alpha particles (4keV). In order to change the total dose accumulated, for each ion fluency the time of exposure was varied. The experiment was carried out considering typical doses accumulated during the ESA Solar Orbiter mission. Results show that ion implantation affects the performances of both single and multilayer coatings.

  3. Chemistry of rocks and soils in Gusev Crater from the alpha particle x-ray spectrometer.

    PubMed

    Gellert, R; Rieder, R; Anderson, R C; Brückner, J; Clark, B C; Dreibus, G; Economou, T; Klingelhöfer, G; Lugmair, G W; Ming, D W; Squyres, S W; D'Uston, C; Wänke, H; Yen, A; Zipfel, J

    2004-08-01

    The alpha particle x-ray spectrometer on the Spirit rover determined major and minor elements of soils and rocks in Gusev crater in order to unravel the crustal evolution of planet Mars. The composition of soils is similar to those at previous landing sites, as a result of global mixing and distribution by dust storms. Rocks (fresh surfaces exposed by the rock abrasion tool) resemble volcanic rocks of primitive basaltic composition with low intrinsic potassium contents. High abundance of bromine (up to 170 parts per million) in rocks may indicate the alteration of surfaces formed during a past period of aqueous activity in Gusev crater. PMID:15297665

  4. Chemistry of rocks and soils at Meridiani Planum from the Alpha Particle X-ray Spectrometer.

    PubMed

    Rieder, R; Gellert, R; Anderson, R C; Brückner, J; Clark, B C; Dreibus, G; Economou, T; Klingelhöfer, G; Lugmair, G W; Ming, D W; Squyres, S W; d'Uston, C; Wänke, H; Yen, A; Zipfel, J

    2004-12-01

    The Alpha Particle X-ray Spectrometer on the Opportunity rover determined major and minor elements of soils and rocks in Meridiani Planum. Chemical compositions differentiate between basaltic rocks, evaporite-rich rocks, basaltic soils, and hematite-rich soils. Although soils are compositionally similar to those at previous landing sites, differences in iron and some minor element concentrations signify the addition of local components. Rocky outcrops are rich in sulfur and variably enriched in bromine relative to chlorine. The interaction with water in the past is indicated by the chemical features in rocks and soils at this site. PMID:15576611

  5. A Metastable Alpha-Particle Irradiation Induced Defect in n-GaAs

    NASA Astrophysics Data System (ADS)

    Auret, F.; Erasmus, Rudolph; Goodman, Stewart

    1994-04-01

    We report the introduction and characterization of a metastable alpha-particle irradiation induced defect, E?8, in n-GaAs by deep level transient spectroscopy (DLTS) using Schottky barrier diodes. The E?8 defect, with an energy level 0.18 eV below the conduction band, as determined by low-field DLTS measurements, could be reversibly transformed (removed and re-introduced) by employing zero and reverse bias anneals, respectively, in the 100 140 K temperature range. The transformation kinetics of E?8 displayed first order behaviour and was found to be charge state dependant.

  6. Mapping alpha-Particle X-Ray Fluorescence Spectrometer (Map-X)

    NASA Technical Reports Server (NTRS)

    Blake, D. F.; Sarrazin, P.; Bristow, T.

    2014-01-01

    Many planetary surface processes (like physical and chemical weathering, water activity, diagenesis, low-temperature or impact metamorphism, and biogenic activity) leave traces of their actions as features in the size range 10s to 100s of micron. The Mapping alpha-particle X-ray Spectrometer ("Map-X") is intended to provide chemical imaging at 2 orders of magnitude higher spatial resolution than previously flown instruments, yielding elemental chemistry at or below the scale length where many relict physical, chemical, and biological features can be imaged and interpreted in ancient rocks.

  7. Absolute number of photons produced by alpha-particles in liquid and gaseous xenon

    NASA Astrophysics Data System (ADS)

    Miyajima, Mitsuhiro; Sasaki, Shinichi; Shibamura, Eido

    1992-02-01

    The Ws which is defined as an average energy expended per scintillation photon, was found to be 16.3 ± 0.3 eV for alpha-particles in liquid xenon, and 49.6 ± 1.1 eV in gaseous xenon, respectively. These results followed from the number of photoelectrons measured with a VUV sensitive photomultiplier tube, which was used as a photodiode. The number of photoelectrons from the photomultiplier photocathode was measured absolutely with a well calibrated charge sensitive amplifier system as a function of distance between the alpha-source and the photomultiplier photocathode. The detection geometries included both reflective and nonreflective walls. The data were well fitted to corresponding curves obtained with a Monte Carlo simulation, and yielded the total number of scintillation photons.

  8. Orbit-averaged drift kinetic equation for the study of alpha-particle transport in tokamaks

    SciTech Connect

    Sager, G.T.; Miley, G.H. (Illinois Univ., Urbana, IL (United States). Fusion Studies Lab.); Burrell, K.H. (General Atomics Co., San Diego, CA (United States))

    1990-11-01

    Neoclassical transport of minority suprathermal alpha particles is investigated. This paper departs from previous investigations in that (a) the banana-width ordering parameter {rho}{sub {theta}}/L is not formally restricted to be a small parameter and (b) a linearized collision operator that retains the effects of pitch-angle scattering, electron and ion drag, and speed diffusion is used. A step model approximation for the large-aspect-ratio, circular-cross-section tokamak magnetic field is adopted to simplify the orbit-averaging procedure. Assuming that the suprathermal alphas are in the banana regime, an asymptotic expansion in {tau}{sub B}/{tau}{sub S} {much lt} l is carried out.

  9. Electron-hole pair generation in SiC high-temperature alpha particle detectors

    NASA Astrophysics Data System (ADS)

    Garcia, Timothy R.; Kumar, Ashutosh; Reinke, Benjamin; Blue, Thomas E.; Windl, Wolfgang

    2013-10-01

    We demonstrate alpha-particle detection in an n-type 4H-SiC Schottky diode detector up to a temperature of 500 °C using an Am-241 disc source. The measured spectra were used to calculate the electron-hole pair creation energy in 4H-SiC and its non-bandgap contribution, which are both found to decrease with increasing temperature. The full width at half maximum (FWHM) of the measured alpha-energy peaks was found to increase exponentially with temperature due to an exponential increase of leakage current. For our measurement system, above 300 °C, where the leakage current was 10-6 A, this increase exceeded the FWHM at room temperature.

  10. Electron-Hole Pair Generation in SiC High-Temperature Alpha Particle Detectors

    E-print Network

    Garcia, Timothy R; Reinke, Benjamin T; Blue, Thomas E; Windl, Wolfgang E

    2013-01-01

    We demonstrate alpha-particle detection in an n-type 4H-SiC Schottky diode detector up to an unprecedented temperature of 500 {\\deg}C using an Am-241 disc source. The measured spectra were used to calculate the electron-hole pair creation energy in 4H-SiC and its non-bandgap contribution, which are both found to decrease with increasing temperature. The full width at half maximum (FWHM) of the measured alpha-energy peaks was found to increase exponentially with temperature due to an exponential increase of leakage current. For our measurement system, above 300 {\\deg}C, where the leakage current was 10-6 A, this increase exceeded the FWHM at room temperature.

  11. Search for {alpha}-states in {sup 13}C via elastic resonant scattering of {alpha} particles on {sup 9}Be

    SciTech Connect

    Lombardo, I.; Campajola, L.; Rosato, E.; Spadaccini, G.; Vigilante, M. [Dipartimento di Scienze Fisiche dell'Universita di Napoli Federico II INFN - Sezione di Napoli, Napoli (Italy)

    2013-07-18

    We will discuss new experimental data concerning the elastic resonant scattering of {alpha}-particles on {sup 9}Be nuclei at bombarding energies from 3.5 MeV up to 9.9 MeV. Several excitation functions have been obtained at different polar angles, mainly in the backward hemisphere in the centre of mass frame. Excitation functions show various anomalies that can be linked to the presence of various excited states in the {sup 13}C compound nucleus. In the literature, some of these states have been proposed to belong to rotational bands built on deformed a-cluster excited state. Unfortunately, up to date the spin-parity assignment of many of these states is doubtful. The set of excitation functions we obtained from the present experiment can contribute to improve spectroscopy of highling excited states of {sup 13}C.

  12. Observation of lunar radon emanation with the Apollo 15 alpha particle spectrometer.

    NASA Technical Reports Server (NTRS)

    Gorenstein, P.; Bjorkholm, P.

    1972-01-01

    The alpha particle spectrometer, a component of the orbital Sim Bay group of 'geochemistry' experiments on Apollo 15, was designed to detect alpha particles emitted during the decay of isotopes of radon gas and her daughter products. The purpose was to measure the gross activity of radon on the lunar surface and to find possible regions of increased local activity. Results are presented from a partial analysis of Apollo 15 data. For the moon as a whole, Rn220 was not observed and the upper limit on its decay rate above the lunar surface is 0.00038 disintegrations/sq cm-sec. Rn222 was marginally observed. Possible variations of radon activity on the lunar surface are being investigated. Po210 (a daughter product of Rn222) has been detected in a broad region from west of Mare Crisium to the Van de Graaff-Orlov region. The observed count rate is (4.6 plus or minus 1.4) x 0.001 disintegrations/sq cm-sec. The observed level of Po210 activity is in excess of the amount that would be in equilibrium with Rn222 by about an order of magnitude. This implies that larger levels of radon emanation have occurred on the moon within a time scale of 10 to 100 years.

  13. Results of the Alpha-Particle-X-Ray Spectrometer on Board of the Mars Exploration Rovers

    NASA Technical Reports Server (NTRS)

    Geller, R.; Zipfel, J.; Brueckner, J.; Dreibus, G.; Lugmair, G.; Rieder, R.; Waenke, H.; Klingelhoefer, G.; Clark, B. C.; Ming, D. W.

    2005-01-01

    The Mars Exploration Rovers Spirit and Opportunity landed at Gusev crater and Meridiani Planum. The Alpha Particle X-ray Spectrometer (APXS) is part of the instrument suite on both rovers. It is equipped with six 244Cm sources which provide x-ray excitation with alpha-particles (PIXE) and x-ray radiation (XRF). This combination allows x-ray spectroscopy of elements from Na to Br in the energy range of 0.9 to 16 keV. X-ray detectors with a high energy resolution of 160 eV at Fe K allow us to separate even closely spaced energy peaks, such as Na, Mg, Al and Si. The APXS is attached to the rover s arm and provides in-situ measurements of the chemical composition of soils, surfaces of rocks and outcrops and their abraded surfaces. This abstract gives an overview of APXS results obtained during the first year of operation on both landing sites.

  14. Study of the absorption coefficient of alpha particles to lower hybrid waves in tokamak

    NASA Astrophysics Data System (ADS)

    Wang, Jianbing; Zhang, Xianmei; Yu, Limin; Zhao, Xiang

    2014-02-01

    Part of the energy of the Lower Hybrid (LH) waves may be absorbed by the ? particles via the so-called perpendicular landau damping mechanism, which depends on various parameters of fusion reactors and the LH waves. In this article, we calculate the absorption coefficient ?? of LH waves due to ? particles. Results show that, the ?? increases with the parallel refraction index n? while deceases with increasing the frequency of LH waves ?LH over a wide range. Higher background plasma temperature and toroidal magnetic field will increase the absorption, and there is a peak value of ?? when ne?8×1019m-3 for ITER-like scenario. The thermal corrections to the cold plasma dispersion relation will change the damping rate to a certain extent under some specific conditions. We have also evaluated the fraction of LH power absorbed by the alpha particles, ? ? 0.47% and 4.1% for an LH frequency of 5 GHz and 3.7 GHz respectively for ITER-like scenario. This work gives the effective reference for the choice of parameters of future fusion reactors.

  15. Study of the absorption coefficient of alpha particles to lower hybrid waves in tokamak

    SciTech Connect

    Wang, Jianbing, E-mail: zhangxm@ecust.edu.cn; Zhang, Xianmei, E-mail: zhangxm@ecust.edu.cn; Yu, Limin, E-mail: zhangxm@ecust.edu.cn; Zhao, Xiang, E-mail: zhangxm@ecust.edu.cn [Department of Physics, East China University of Science and Technology, P.O. Box 385, Shanghai 200237 (China)

    2014-02-12

    Part of the energy of the Lower Hybrid (LH) waves may be absorbed by the ? particles via the so-called perpendicular landau damping mechanism, which depends on various parameters of fusion reactors and the LH waves. In this article, we calculate the absorption coefficient ?{sub ?} of LH waves due to ? particles. Results show that, the ?{sub ?} increases with the parallel refraction index n{sub ?} while deceases with increasing the frequency of LH waves ?{sub LH} over a wide range. Higher background plasma temperature and toroidal magnetic field will increase the absorption, and there is a peak value of ?{sub ?} when n{sub e}?8×10{sup 19}m{sup ?3} for ITER-like scenario. The thermal corrections to the cold plasma dispersion relation will change the damping rate to a certain extent under some specific conditions. We have also evaluated the fraction of LH power absorbed by the alpha particles, ? ? 0.47% and 4.1% for an LH frequency of 5 GHz and 3.7 GHz respectively for ITER-like scenario. This work gives the effective reference for the choice of parameters of future fusion reactors.

  16. Feasibility study on the use of polyallyldiglycol-carbonate cell dishes in TUNEL assay for alpha particle radiobiological experiments

    NASA Astrophysics Data System (ADS)

    Chan, K. F.; Yum, E. H. W.; Wan, C. K.; Fong, W. F.; Yu, K. N.

    2007-08-01

    In the present work, we have studied the feasibility of a method based on polyallyldiglycol-carbonate (PADC) films to investigate the effects of alpha particles on HeLa cervix cancer cells. Thin PADC films with thickness of about 20 ?m were prepared from commercially available CR-39 films by chemical etching to fabricate custom-made petri dishes for cell culture, which could accurately record alpha particle hit positions. A special method involving "base tracks" for aligning the images of cell nuclei and alpha particle hits has been proposed, so that alpha particle transversals of cell nuclei can be visually counted. Radiobiological experiments were carried out to induce DNA damages, with the TdT-mediated d UTP Nick- End Labeling (TUNEL) fluorescence method employed to detect DNA strand breaks. The staining results were investigated by flow cytometer. The preliminary results showed that more strand breaks occurred in cells hit by alpha particles with lower energies. Moreover, large TUNEL positive signals were obtained even with small percentages of cells irradiated and TUNEL signals were also obtained from non-targeted cells. These provided evidence for the bystander effect.

  17. Selective Alpha-Particle Mediated Depletion of Tumor Vasculature with Vascular Normalization

    PubMed Central

    Seshan, Surya V.; Kappel, Barry J.; Chattopadhyay, Debjit; May, Chad; McDevitt, Michael R.; Nolan, Daniel; Mittal, Vivek; Benezra, Robert; Scheinberg, David A.

    2007-01-01

    Background Abnormal regulation of angiogenesis in tumors results in the formation of vessels that are necessary for tumor growth, but compromised in structure and function. Abnormal tumor vasculature impairs oxygen and drug delivery and results in radiotherapy and chemotherapy resistance, respectively. Alpha particles are extraordinarily potent, short-ranged radiations with geometry uniquely suitable for selectively killing neovasculature. Methodology and Principal Findings Actinium-225 (225Ac)-E4G10, an alpha-emitting antibody construct reactive with the unengaged form of vascular endothelial cadherin, is capable of potent, selective killing of tumor neovascular endothelium and late endothelial progenitors in bone-marrow and blood. No specific normal-tissue uptake of E4G10 was seen by imaging or post-mortem biodistribution studies in mice. In a mouse-model of prostatic carcinoma, 225Ac-E4G10 treatment resulted in inhibition of tumor growth, lower serum prostate specific antigen level and markedly prolonged survival, which was further enhanced by subsequent administration of paclitaxel. Immunohistochemistry revealed lower vessel density and enhanced tumor cell apoptosis in 225Ac-E4G10 treated tumors. Additionally, the residual tumor vasculature appeared normalized as evident by enhanced pericyte coverage following 225Ac-E4G10 therapy. However, no toxicity was observed in vascularized normal organs following 225Ac-E4G10 therapy. Conclusions The data suggest that alpha-particle immunotherapy to neovasculature, alone or in combination with sequential chemotherapy, is an effective approach to cancer therapy. PMID:17342201

  18. Alfven waves, alpha particles, and pickup ions in the solar wind

    NASA Technical Reports Server (NTRS)

    Goldstein, B. E.; Neugebauer, M.; Smith, E. J.

    1995-01-01

    Past studies of the properties of Alfven waves in the solar wind have indicated that (1) the amplitude of the velocity fluctuations is almost always smaller than expected on the basis of the amplitude of the field fluctuations, even when the anisotropy of the plasma is taken into account, and (2) the alpha particles do not participate in the wave motions because they 'surf' on the waves carried by the proton fluid. Ulysses data are used to demonstrate that (1) the discrepancy between the velocity and field fluctuations is greater at high heliographic latitudes than in the ecliptic plane, and (2) the alphas do participate in the waves, being either in phase or out of phase with the proton motions depending on whether the differential flow speed between the alphas and protons is greater than or less than the 'observed' wave speed, B(sub o)(delta v squared / delta B squared)exp 1/2, as determined from the ratio of the amplitudes of the velocity and magnetic fluctuations. It is proposed that the modification of Alfven wave propagation speed is due to pressure anisotropies resulting from asymmetric distributions of interstellar pickup ions. If the proposed explanation is correct, it indicates that scattering of pickup ions onto a (bi)spherical shell may not be as complete as generally supposed.

  19. Design, spectrum measurements and simulations for a 238Pu alpha-particle irradiator for bystander effect and genomic instability experiments.

    PubMed

    Hakanen, Arvi; Siiskonen, Teemu; Pöllänen, Roy; Kosunen, Antti; Turunen, Asko; Belyakov, Oleg

    2006-08-01

    Design, spectrum measurements and simulations for an alpha-particle irradiator for bystander effect and genomic instability experiments are presented. Measured alpha-particle energy spectra were used to confirm the characteristics of the source of the irradiator specified by the manufacturer of the source. The spectra were measured in vacuum with a high-resolution spectrometer and simulated with an AASI Monte Carlo code. As a next step, we simulated alpha-particle energy spectra at the target plane of the irradiator for three different source-to-target distances. In these simulations, helium was used as the medium between the source and the exit window of the irradiator; its pressure and temperature corresponded to those of the ambient air. Mean energies and full-widths at half-maximum (FWHM) were calculated for the three different helium gas tracks. PMID:16618543

  20. Propagation distance of the alpha-particle-induced bystander effect: the role of nuclear traversal and gap junction communication.

    PubMed

    Gaillard, Sylvain; Pusset, David; de Toledo, Sonia M; Fromm, Michel; Azzam, Edouard I

    2009-05-01

    When cell populations are exposed to low-dose alpha-particle radiation, a significant fraction of the cells will not be traversed by a radiation track. However, stressful effects occur in both irradiated and bystander cells in the population. Characterizing these effects, and investigating their underlying mechanism(s), is critical to understanding human health risks associated with exposure to alpha particles. To this end, confluent normal human fibroblast cultures were grown on polyethylene terephthalate foil grafted to an ultrathin solid-state nuclear track detector and exposed under non-perturbing conditions to low-fluence alpha particles from a broadbeam irradiator. Irradiated and affected bystander cells were localized with micrometer precision. The stress-responsive protein p21(Waf1) (also known as CDKN1A) was induced in bystander cells within a 100-microm radius from an irradiated cell. The mean propagation distance ranged from 20 to 40 microm around the intranuclear alpha-particle impact point, which corresponds to a set of approximately 30 cells. Nuclear traversal, induced DNA damage, and gap junction communication were critical contributors to propagation of this stressful effect. The strategy described here may be ideal to investigate the size of radiation-affected target and the relative contribution of different cellular organelles to bystander effects induced by energetic particles, which is relevant to radioprotection and cancer radiotherapy. PMID:19580486

  1. An SiC\\/GaN Detector\\/Front-End Detection System for High-Resolution Alpha-Particle Spectroscopy

    Microsoft Academic Search

    A. Pullia; G. Bertuccio; D. Maiocchi; S. Caccia; F. Zocca

    2008-01-01

    An alpha-particle spectrometer has been assembled, consisting of an epitaxial 50 mum thick 4H silicon carbide (SiC) detector connected to a gallium-nitride (GaN) high-electron mobility transistor (HEMT) used as input transistor of the front-end electronics. The depleted layer of the SiC diode detector was sufficient to stop all alpha particles in the 4.8-MeV to 5.8-MeV energy range. An excellent energy

  2. An alpha particle measurement system using an energetic neutral helium beam in ITER (invited)

    SciTech Connect

    Sasao, M.; Tanaka, N.; Terai, K.; Kaneko, O. [Graduate school of Engineering, Tohoku University, Sendai 980-8579 (Japan); Kisaki, M.; Kobuchi, T.; Tsumori, K.; Okamoto, A.; Kitajima, S. [National Institute for Fusion Science, Toki, Gifu 509-5292 (Japan); Shinto, K. [IFMIF R and D Center, Japan Atomic Energy Agency, Rokkasho, Aomori 039-3212 (Japan); Wada, M. [Graduate School of Engineering, Doshisha University, Kyotanabe, Kyoto 610-0321 (Japan)

    2012-02-15

    An energetic helium neutral beam is involved in the beam neutralization measurement system of alpha particles confined in a DT fusion plasma. A full size strong-focusing He{sup +} ion source (2 A, the beam radius of 11.3 mm, the beam energy less than 20 keV). Present strong-focusing He{sup +} ion source shows an emittance diagram separated for each beamlet of multiple apertures without phase space mixing, despite the space charge of a beamlet is asymmetric and the beam flow is non-laminar. The emittance of beamlets in the peripheral region was larger than that of center. The heat load to the plasma electrode was studied to estimate the duty factor for the ITER application.

  3. Solar flare protons and alpha particles during the last three solar cycles

    NASA Technical Reports Server (NTRS)

    Goswami, J. N.; Mcguire, R. E.; Reedy, R. C.; Lal, D.; Jha, R.

    1988-01-01

    This paper presents solar-flare-associated proton and alpha-particle fluxes determined for major events from October 1972 through March 1987 (the period that represents the last part of solar cycle 20 and the whole of solar cycle 21), using data obtained by detectors on board the IMP-7 and IMP-8 satellites, along with earlier obtained data for cycle 20. It was found that the average omnidirectional flux of protons with kinetic energy above 10 MeV for cycle 21 (64/sq cm per sec) is lower than the corresponding number for cycle 20 (92/sq cm per sec) and for the cycle 19 (378/sq cm per sec). No definitive correlation was found to exist between cycle-averaged solar flare proton fluxes and peak sunspot numbers.

  4. Study of the beta-delayed alpha-particle emission of [sup 16]N

    SciTech Connect

    Zhao, Z.; France, R.H. III; Lai, K.S.; Gai, M. (A.W. Wright Nuclear Structure Laboratory, Department of Physics, Yale University, New Haven, Connecticut 06511 (United States)); Wilds, E.L. (Department of Physics, The University of Connecticut, Storrs, Connecticut 06268 (United States)); Kryger, R.A.; Winger, J.A. (National Superconducting Cyclotron Laboratory, Michigan State University, East Lansing, Michigan 48824 (United States)); Beard, K.B. (Department of Physics, Hampton University, Hampton, Virgina 23668 (United States))

    1993-07-01

    The beta-delayed alpha-particle emission of [sup 16]N has been studied, with [sup 16]N nuclei produced using 80 MeV/nucleon [sup 18]O beams on [sup 9]Be targets. The [sup 16]N secondary nuclei were mass analyzed and separated from the reaction products using the Michigan State University A1200 isotope separator. A detector array, including four thin surface barrier detectors, a [ital p]-[ital i]-[ital n] diode, a Ge gamma-ray detector, and a two-dimensional position sensitive parallel plate avalanche counter, was used for implantation and study of the separated nuclei. A beta-decay branching ratio of (1.3[plus minus]0.3)[times]10[sup [minus]5] to the 1[sup [minus

  5. Receiver calibration of the JET fast ion and alpha particle diagnostic

    SciTech Connect

    Machuzak, J.S.; Woskov, P.P. (MIT Plasma Fusion Center, Cambridge, Massachusetts 02139 (United States)); Bindslev, H.; Comiskey, M.; Fessey, J.; Hoekzema, J.A.; Hughes, T.P. (JET Joint Undertaking, Abingdon, Oxon OX14 3EA (United Kingdom)); Orsitto, F. (ENEA CRE Frascati (Italy))

    1992-10-01

    A collective Thomson scattering diagnostic is being implemented at JET to diagnose the velocity distribution and density of alpha particles and energetic ions. This diagnostic consists of a number of major subsystems including: a high-power 140-GHz gyrotron, a 32-channel 12-GHz bandwidth heterodyne receiver, efficient corrugated waveguide systems, variable polarizers, and in vacuum beam steering mirrors. Proper calibration of these subsystems for signal level losses, positioning, and polarization is imperative for the successful operation of the diagnostic and to facilitate the interpretation of the scattered data. A low-power Gunn oscillator was used to verify the polarization rotation induced by the seven miter bends in the receiver transmission line. The full bandwidth receiver front end losses, including the sapphire tokamak vacuum window, were initially calibrated by using the hot tokamak vessel wall as a blackbody source at approximately 310 {degree}C. Background ECE measurements will be presented.

  6. Mitigation of radiation nephropathy after internal {alpha}-particle irradiation of kidneys

    SciTech Connect

    Jaggi, Jaspreet Singh [Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Seshan, Surya V. [Department of Pathology, Cornell University Weill Medical College, New York, NY (United States); McDevitt, Michael R. [Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Sgouros, George [Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD (United States); Hyjek, Elizabeth [Department of Pathology, Cornell University Weill Medical College, New York, NY (United States); Scheinberg, David A. [Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, NY (United States) and Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY (United States)]. E-mail: d-scheinberg@ski.mskcc.org

    2006-04-01

    Purpose: Internal irradiation of kidneys as a consequence of radioimmunotherapy, radiation accidents, or nuclear terrorism can result in radiation nephropathy. We attempted to modify pharmacologically, the functional and morphologic changes in mouse kidneys after injection with the actinium ({sup 225}Ac) nanogenerator, an in vivo generator of {alpha}- and {beta}-particle emitting elements. Methods and Materials: The animals were injected with 0.35 {mu}Ci of the {sup 225}Ac nanogenerator, which delivers a dose of 27.6 Gy to the kidneys. Then, they were randomized to receive captopril (angiotensin-converting enzyme inhibitor), L-158,809 (angiotensin II receptor-1 blocker), spironolactone (aldosterone receptor antagonist), or a placebo. Results: Forty weeks after the {sup 225}Ac injection, the placebo-control mice showed a significant increase in blood urea nitrogen (BUN) (87.6 {+-} 6.9 mg/dL), dilated Bowman spaces, and tubulolysis with basement membrane thickening. Captopril treatment accentuated the functional (BUN 119.0 {+-} 4.0 mg/dL; p <0.01 vs. placebo controls) and histopathologic damage. In contrast, L-158,809 offered moderate protection (BUN 66.6 {+-} 3.9 mg/dL; p = 0.02 vs. placebo controls). Spironolactone treatment, however, significantly prevented the development of histopathologic and functional changes (BUN 31.2 {+-} 2.5 mg/dL; p <0.001 vs. placebo controls). Conclusions: Low-dose spironolactone and, to a lesser extent, angiotensin receptor-1 blockade can offer renal protection in a mouse model of internal {alpha}-particle irradiation.

  7. Renal tubulointerstitial changes after internal irradiation with alpha-particle-emitting actinium daughters.

    PubMed

    Jaggi, Jaspreet Singh; Seshan, Surya V; McDevitt, Michael R; LaPerle, Krista; Sgouros, George; Scheinberg, David A

    2005-09-01

    The effect of external gamma irradiation on the kidneys is well described. However, the mechanisms of radiation nephropathy as a consequence of targeted radionuclide therapies are poorly understood. The functional and morphologic changes were studied chronologically (from 10 to 40 wk) in mouse kidneys after injection with an actinium-225 (225Ac) nanogenerator, a molecular-sized, antibody-targeted, in vivo generator of alpha-particle-emitting elements. Renal irradiation from free, radioactive daughters of 225Ac led to time-dependent reduction in renal function manifesting as increase in blood urea nitrogen. The histopathologic changes corresponded with the decline in renal function. Glomerular, tubular, and endothelial cell nuclear pleomorphism and focal tubular cell injury, lysis, and karyorrhexis were observed as early as 10 wk. Progressive thinning of the cortex as a result of widespread tubulolysis, collapsed tubules, glomerular crowding, decrease in glomerular cellularity, interstitial inflammation, and an elevated juxtaglomerular cell count were noted at 20 to 30 wk after treatment. By 35 to 40 wk, regeneration of simplified tubules with tubular atrophy and loss with focal, mild interstitial fibrosis had occurred. A lower juxtaglomerular cell count with focal cytoplasmic vacuolization, suggesting increased degranulation, was also observed in this period. A focal increase in tubular and interstitial cell TGF-beta1 expression starting at 20 wk, peaking at 25 wk, and later declining in intensity with mild increase in the extracellular matrix deposition was noticed. These findings suggest that internally delivered alpha-particle irradiation-induced loss of tubular epithelial cells triggers a chain of adaptive changes that result in progressive renal parenchymal damage accompanied by a loss of renal function. These findings are dissimilar to those seen after gamma or beta irradiation of kidneys. PMID:15987754

  8. Cancer Stem Cell Targeting Using the Alpha-Particle Emitter, 213Bi: Mathematical Modeling and Feasibility Analysis

    PubMed Central

    Sgouros, George; Song, Hong

    2010-01-01

    There is increasing recognition that treatment failure in cancer may be associated with the failure to sterilize a small subpopulation of tumor cells that have been characterized as tumor stem cells. Defined as cells that are able to self-renew and also to replenish a phenotypically diverse tumor-cell population, such cells are also considered resistant to chemotherapy. These characteristics are optimal for targeting by using alpha-particle-emitting radionuclides. Because of their high-energy deposition density per track, alpha-particles are capable of targeting single cells or small clusters of cells with minimal normal organ toxicity. The DNA damage induced by alpha-particles is largely irreparable and, therefore, alpha-particle-induced damage is minimally susceptible to resistance mechanisms. In this work, theoretical modeling was performed to examine the potential of alpha-emitter targeting of such small clusters of cancer stem cells. Critical parameters influencing efficacy and toxicity were identified and their relationship elucidated. The results identify specific activity, antigen site density, and number of target cells as critical parameters for effective cell killing and demonstrate substantial efficacy gains by targeting a smaller number of stem cells, as opposed to the entire tumor-cell population. PMID:18298331

  9. Particle size and interfacial effects on heat transfer characteristics of water and {alpha}-SiC nanofluids.

    SciTech Connect

    Timofeeva, E.; Smith, D. S.; Yu, W.; France, D. M.; Singh, D.; Routbort, J. L. (Energy Systems); ( NE); (Univ. of Illinois)

    2010-01-01

    The effect of average particle sizes on basic macroscopic properties and heat transfer performance of {alpha}-SiC/water nanofluids was investigated. The average particle sizes, calculated from the specific surface area of nanoparticles, were varied from 16 to 90 nm. Nanofluids with larger particles of the same material and volume concentration provide higher thermal conductivity and lower viscosity increases than those with smaller particles because of the smaller solid/liquid interfacial area of larger particles. It was also demonstrated that the viscosity of water-based nanofluids can be significantly decreased by pH of the suspension independently from the thermal conductivity. Heat transfer coefficients were measured and compared to the performance of base fluids as well as to nanofluids reported in the literature. Criteria for evaluation of the heat transfer performance of nanofluids are discussed and optimum directions in nanofluid development are suggested.

  10. Study of excitation functions of alpha-particle induced nuclear reactions on holmium for 167Tm production.

    PubMed

    Tárkányi, F; Hermanne, A; Király, B; Takács, S; Ignatyuk, A V

    2010-03-01

    (167)Tm is a candidate radioisotope for both nuclear medicine diagnostics and therapy due to its emitted Auger-electrons, low energy X- and gamma-rays. In the frame of a systematic study of excitation functions for production of medically relevant radioisotopes by charged particle induced reactions on rare earths, the (165)Ho(alpha,2n)(167)Tm reaction and the (165)Ho(alpha,n)(168)Tm, (165)Ho(alpha,3n)(166)Tm, (165)Ho(alpha,4n)(165)Tm side reactions were measured up to 40 MeV by the stacked foil irradiation technique and gamma-ray spectroscopy. The measured results were compared to the ALICE-IPPE and EMPIRE-II theoretical curves. Thick target yields, impurity levels and specific activities were deduced and compared with the same parameters for other charged particle production routes of (167)Tm. PMID:20022515

  11. Alpha-particle-driven instability of alfven waves in a tandem mirror. Final summary report, 21 February-20 May 1985

    SciTech Connect

    Ho, S.K.

    1985-08-20

    Alpha particles born at D-T fusion are mirror confined in the tandem mirror due to their relatively high energy. Therefore, they have a loss-cone type distribution in the velocity space. This anisotropy is susceptible to microinstability. The objective of this work is to study the possible instability that can be driven by the alpha loss-cone. The low frequency (at the order of the ion cyclotron frequency) wave spectrum is studied to seek the waves that can be destabilized by the alphas. The radial mode structure is found for the growth rate calculation. The alpha particle distribution with a loss-cone is obtained from a Legendre function expansion and a diffusion front method. The growth rate of the instability is formulated from linear stability theory and computed numerically. A marginal stability boundary in the ion density and temperature parameters is calculated.

  12. Investigations of factors affecting the use of uranium metal as a source of alpha particles for the evaluation of alpha track detectors

    E-print Network

    Voirin, Marc

    1994-01-01

    , an uranium foil was used as the alpha particle source. The foil created new problems which needed to be studied in detail. Among these problems, the effect of the thickness of the oxide layer on the uranium metal foil surface was the most important. To study...

  13. Investigations of factors affecting the use of uranium metal as a source of alpha particles for the evaluation of alpha track detectors 

    E-print Network

    Voirin, Marc

    1994-01-01

    , an uranium foil was used as the alpha particle source. The foil created new problems which needed to be studied in detail. Among these problems, the effect of the thickness of the oxide layer on the uranium metal foil surface was the most important. To study...

  14. 2948 IEEE TRANSACTIONS ON PLASMA SCIENCE, VOL. 39, NO. 11, NOVEMBER 2011 Simulation of Alpha Particles in Rotating Plasma

    E-print Network

    throat, and these electrodes limited the rotation speed to the Alfven critical ionization velocity (CIV2948 IEEE TRANSACTIONS ON PLASMA SCIENCE, VOL. 39, NO. 11, NOVEMBER 2011 Simulation of Alpha Particles in Rotating Plasma Interacting With a Stationary Ripple Abraham J. Fetterman and Nathaniel J

  15. Channeling of Fusion Alpha-Particle Power Using Minority Ion Catalysis A. I. Zhmoginov and N. J. Fisch

    E-print Network

    , with electrons kept cold, so that the effective fusion reactivity can be increased [9­11]. The meansChanneling of Fusion Alpha-Particle Power Using Minority Ion Catalysis A. I. Zhmoginov and N. J greatly facilitate controlled nuclear fusion. The parameter range for achieving this temperature disparity

  16. Lower hybrid instability driven by mono-energy {alpha}-particles with finite pitch angle spread in a plasma

    SciTech Connect

    Kumar, Pawan; Singh, Vishwesh; Tripathi, V. K. [Department of Physics, IIT Delhi, New Delhi-110016 (India)

    2013-02-15

    A kinetic formalism of lower hybrid wave instability, driven by mono-energy {alpha}-particles with finite pitch angle spread, is developed. The instability arises through cyclotron resonance interaction with high cyclotron harmonics of {alpha}-particles. The {alpha}-particles produced in D-T fusion reactions have huge Larmor radii ({approx}10 cm) as compared to the wavelength of the lower hybrid wave, whereas their speed is an order of magnitude smaller than the speed of light in vacuum. As a result, large parallel phase velocity lower hybrid waves, suitable for current drive in tokamak, are driven unstable via coupling to high cyclotron harmonics. The growth rate decreases with increase in pitch angle spread of the beam. At typical electron density of {approx}10{sup 19} m{sup -3}, magnetic field {approx}4 Tesla and {alpha}-particle concentration {approx}0.1%, the large parallel phase velocity lower hybrid wave grows on the time scale of 20 ion cyclotron periods. The growth rate decreases with plasma density.

  17. Cytotoxicity of alpha-particle-emitting astatine-211-labelled antibody in tumour spheroids: no effect of hyperthermia.

    PubMed Central

    Hauck, M. L.; Larsen, R. H.; Welsh, P. C.; Zalutsky, M. R.

    1998-01-01

    The high linear energy transfer, alpha-particle-emitting radionuclide astatine-211 (211At) is of interest for certain therapeutic applications; however, because of the 55- to 70-microm path length of its alpha-particles, achieving homogeneous tracer distribution is critical. Hyperthermia may enhance the therapeutic efficacy of alpha-particle endoradiotherapy if it can improve tracer distribution. In this study, we have investigated whether hyperthermia increased the cytotoxicity of an 211At-labelled monoclonal antibody (MAb) in tumour spheroids with a radius (approximately 100 microm) greater than the range of 211At alpha-particles. Hyperthermia for 1 h at 42 degrees C was used because this treatment itself resulted in no regrowth delay. Radiolabelled chimeric MAb 81C6 reactive with the extracellular matrix antigen tenascin was added to spheroids grown from the D-247 MG human glioma cell line at activity concentrations ranging from 0.125 to 250 kBq ml(-1). A significant regrowth delay was observed at 125 and 250 kBq ml(-1) in both hyperthermia-treated and untreated spheroids. For groups receiving hyperthermia, no increase in cytotoxicity was seen compared with normothermic controls at any activity concentration. These results and those from autoradiographs indicate that hyperthermia at 42 degrees C for 1 h had no significant effect on the uptake or distribution of this antitenascin MAb in D-247 MG spheroids. Images Figure 4 Figure 5 PMID:9514054

  18. Determination of Geometry and Absorption Effects and Their Impact on the Accuracy of Alpha Particle Soft Error Rate Extrapolations

    Microsoft Academic Search

    Robert C. Baumann; Daniele Radaelli

    2007-01-01

    The results of a physical experiment and extensive simulation runs are presented for the first time demonstrating the significant effects of geometry and air absorption on accelerated alpha particle soft error rate tests. These results show that geometry and absorption must be properly accounted for even when the source is in close proximity to the device to avoid substantial underestimation

  19. Determining the impact of alpha-particle-emitting contamination from the Fukushima Daiichi disaster on Japanese manufacturing sites

    Microsoft Academic Search

    Robert C. Baumann

    2011-01-01

    We briefly review nuclear reactor operation from the point of view of the major radioactive contaminants formed and consider how these were released and dispersed into the air, water, and soil around Fukushima. The risk of contamination from alpha-particle-emitting uranium and plutonium isotopes at semiconductor manufacturing sites in Japan is considered from theoretical aspects. We report the results of low

  20. Production and evaluation of ZnS thin films by the MOCVD technique as alpha-particle detectors

    Microsoft Academic Search

    H. Kashani

    1996-01-01

    Zinc sulphide thin films are deposited on several substrates such as glass, quartz, silicon, Teflon and Mylar. The chemical reaction of hydrogen sulphide with dimethylzinc is utilised for the deposition process. The optimum working conditions (deposition rate versus flow rate, temperature and pressure) are obtained. The acquired films are characterised and the films are examined for alpha-particle sensitivity. In general,

  1. Low doses of alpha particles do not induce sister chromatid exchanges in bystander Chinese hamster cells defective in homologous recombination

    SciTech Connect

    Nagasawa, H; Wilson, P F; Chen, D J; Thompson, L H; Bedford, J S; Little, J B

    2007-10-26

    We reported previously that the homologous recombinational repair (HRR)-deficient Chinese hamster mutant cell line irs3 (deficient in the Rad51 paralog Rad51C) showed only a 50% spontaneous frequency of sister chromatid exchange (SCE) as compared to parental wild-type V79 cells. Furthermore, when irradiated with very low doses of alpha particles, SCEs were not induced in irs3 cells, as compared to a prominent bystander effect observed in V79 cells (Nagasawa et al., Radiat. Res. 164, 141-147, 2005). In the present study, we examined additional Chinese hamster cell lines deficient in the Rad51 paralogs Rad51C, Rad51D, Xrcc2, and Xrcc3 as well as another essential HRR protein, Brca2. Spontaneous SCE frequencies in non-irradiated wild-type cell lines CHO, AA8 and V79 were 0.33 SCE/chromosome, whereas two Rad51C-deficient cell lines showed only 0.16 SCE/chromosome. Spontaneous SCE frequencies in cell lines defective in Rad51D, Xrcc2, Xrcc3, and Brca2 ranged from 0.23-0.33 SCE/chromosome, 0-30% lower than wild-type cells. SCEs were induced significantly 20-50% above spontaneous levels in wild-type cells exposed to a mean dose of 1.3 mGy of alpha particles (<1% of nuclei traversed by an alpha particle). However, induction of SCEs above spontaneous levels was minimal or absent after {alpha}-particle irradiation in all of the HRR-deficient cell lines. These data suggest that Brca2 and the Rad51 paralogs contribute to DNA damage repair processes induced in bystander cells (presumably oxidative damage repair in S-phase cells) following irradiation with very low doses of alpha particles.

  2. Deceleration of Alpha Particles in the Solar Wind by Instabilities and the Rotational Force: Implications for Heating, Azimuthal Flow, and the Parker Spiral Magnetic Field

    E-print Network

    Verscharen, Daniel; Bourouaine, Sofiane; Hollweg, Joseph V

    2014-01-01

    Protons and alpha particles in the fast solar wind are only weakly collisional and exhibit a number of non-equilibrium features, including relative drifts between particle species. Two non-collisional mechanisms have been proposed for limiting differential flow between alpha particles and protons: plasma instabilities and the rotational force. Both mechanisms decelerate the alpha particles. In this paper, we derive an analytic expression for the rate $Q_{\\mathrm{flow}}$ at which energy is released by alpha-particle deceleration, accounting for azimuthal flow and conservation of total momentum. We find that $Q_{\\mathrm{flow}} > 0 $ at $r r_{\\mathrm{crit}}$. We compare the value of $Q_{\\mathrm{flow}}$ at $rUlysses spacecraft. We find that $Q_{\\mathrm{flow}}$ exceeds $Q_{\\alpha}$ at $r < 1\\,\\mathrm{AU}$, $Q_{...

  3. Particle generator

    DOEpatents

    Hess, Wayne P.; Joly, Alan G.; Gerrity, Daniel P.; Beck, Kenneth M.; Sushko, Peter V.; Shlyuger, Alexander L.

    2005-06-28

    Energy tunable solid state sources of neutral particles are described. In a disclosed embodiment, a halogen particle source includes a solid halide sample, a photon source positioned to deliver photons to a surface of the halide, and a collimating means positioned to accept a spatially defined plume of hyperthermal halogen particles emitted from the sample surface.

  4. Recommended Energy and Intensity Values of Alpha Particles from Radioactive Decay

    Microsoft Academic Search

    A. Rytz

    1991-01-01

    The present compilation in the third revised version of a collection of selected α-particle data found in the literature. It includes 516 values from 286 α-particle emitters, corresponding to an increase of 12% and 17%, respectively, over the 1979 version. The weighted means form a consistent set of recommended energy and branching values.

  5. Alpha-Particle/Proton Differential Flow in the Solar Wind: Implications for Plasma Heating, Azimuthal Flow, and the Parker Spiral Magnetic Field

    NASA Astrophysics Data System (ADS)

    Verscharen, D.; Bourouaine, S.; Chandran, B. D. G.

    2014-12-01

    Protons and alpha particles in the fast solar wind are only weakly collisional and exhibit a number of non-equilibrium features, including temperature anisotropies and relative drifts along the direction of the background magnetic field. Two mechanisms have been proposed for limiting differential flow between alpha particles and protons: plasma instabilities and the rotational force. Both mechanisms decelerate the alpha particles - for example, the Alfvén/ion-cyclotron and fast-magnetosonic/whistler instabilities limit the drift velocity to a value comparable to the Alfvén speed, which decreases with increasing heliocentric distance r. However, while plasma instabilities transform bulk-flow kinetic energy into heat and plasma waves, the rotational force does not. We present an analytic expression for the rate Qflow at which energy is released when alpha particles are decelerated by instabilities. We find that Qflow becomes zero at a critical radius r=rcrit, where rcrit is between 1.5 AU and 2 AU in the fast solar wind in the ecliptic plane, and rcrit increases with increasing heliographic latitude. We show that instabilities control the deceleration of alpha particles at ralpha particles at r>rcrit. We compare the value of Qflow at ralpha particles deduced from in-situ measurements of fast-wind streams from the Helios and Ulysses spacecraft. We find that Qflow exceeds the empirical heating rate for alpha particles at r<1 AU. We conclude that the continuous energy input from alpha-particle deceleration at ralpha-particle drift for the azimuthal flow velocities of the ions and for the Parker spiral magnetic field.

  6. Particle energization

    SciTech Connect

    Gisler, G.

    1990-01-01

    A first-principles approach to the physics of particle energization is presented. The general physics of particle acceleration is then applied to a number of the classical astrophysical mechanisms for accelerating particles, with references to recent literature where these are used in specific circumstances. The solar flare is recommended as a microcosm for studying particle acceleration because many different processes seem to be occurring in close proximity, and there is abundant high time resolution data for diagnosing those processes. Finally, a list of possible sites and mechanisms for particle acceleration in spiral galaxies is presented. 66 refs., 6 figs., 3 tabs.

  7. Particle Detectors

    NASA Astrophysics Data System (ADS)

    Grupen, Claus; Shwartz, Boris

    2011-09-01

    Preface to the first edition; Preface to the second edition; Introduction; 1. Interactions of particles and radiation with matter; 2. Characteristic properties of detectors; 3. Units of radiation measurements and radiation sources; 4. Accelerators; 5. Main physical phenomena used for particle detection and basic counter types; 6. Historical track detectors; 7. Track detectors; 8. Calorimetry; 9. Particle identification; 10. Neutrino detectors; 11. Momentum measurement and muon detection; 12. Ageing and radiation effects; 13. Example of a general-purpose detector: Belle; 14. Electronics; 15. Data analysis; 16. Applications of particle detectors outside particle physics; 17. Glossary; 18. Solutions; 19. Resumé; Appendixes; Index.

  8. Thorium and actinium polyphosphonate compounds as bone-seeking alpha particle-emitting agents.

    PubMed

    Henriksen, Gjermund; Bruland, Oyvind S; Larsen, Roy H

    2004-01-01

    The present study explores the use of alpha-particle-emitting, bone-seeking agents as candidates for targeted radiotherapy. Actinium and thorium 1,4,7,10 tetraazacyclododecane N,N',N'',N''' 1,4,7,10-tetra(methylene) phosphonic acid (DOTMP) and thorium-diethylene triamine N,N',N'' penta(methylene) phosphonic acid (DTMP) were prepared and their biodistribution evaluated in conventional Balb/C mice at four hours after injection. All three bone-seeking agents showed a high uptake in bone and a low uptake in soft tissues. Among the soft tissue organs, only kidney had a relatively high uptake. The femur/kidney ratios for 227Th-DTMP, 228-Ac-DOTMP and 227Th-DOTMP were 14.2, 7.6 and 6.0, respectively. A higher liver uptake of 228Ac-DOTMP was seen than for 227Th-DTMP and 227Th-DOTMP. This suggests that some demetallation of the 228Ac-DOTMP complex had occurred. The results indicate that 225Ac-DOTMP, 227Th-DOTMP and 227Th-DTMP have promising properties as potential therapeutic bone-seeking agents. PMID:15015582

  9. The Alpha Particle X-Ray Spectrometer (APXS): Results from Gusev Crater and Calibration Report

    NASA Technical Reports Server (NTRS)

    Gellert, R.; Rieder, R.; Brueckner, J.; Clark, B.; Dreibus, G.; Klingelhoefer, G.; Lugmair, G.; Ming, D.; Waenke, H.; Yen, A.; Zipfel, J.; Squyres, S.

    2006-01-01

    The chemical composition of rocks and soils on Mars analyzed during the Mars Exploration Rover Spirit Mission was determined by X-ray analyses with the Alpha Particle X-Ray Spectrometer (APXS). Details of the data analysis method and the instrument calibration are presented. Measurements performed on Mars to address geometry effects and background contributions are shown. Cross calibration measurements among several instrument sensors and sources are discussed. An unintentional swap of the two flight instruments is evaluated. New concentration data acquired during the first 470 sols of rover Spirit in Gusev Crater are presented. There are two geological regions, the Gusev plains and the Columbia Hills. The plains contain soils that are very similar to previous landing sites on Mars. A meteoritic component in the soil is identified. Rocks in the plains revealed thin weathering rinds. The underlying abraded rock was classified as primitive basalt. One of these rocks contained significant Br that is probably associated with vein-filling material of different composition. One of the trenches showed large subsurface enrichments of Mg, S, and Br. Disturbed soils and rocks in the Columbia Hills revealed different elemental compositions. These rocks are significantly weathered and enriched in mobile elements, such as P, S, Cl, or Br. Even abraded rock surfaces have high Br concentrations. Thus, in contrast to the rocks and soils in the Gusev Plains, the Columbia Hills material shows more significant evidence of ancient aqueous alteration.

  10. Non-equilibrium effects in alpha-particle-induced reactions in light, medium and heavy nuclei up to 120 MeV

    Microsoft Academic Search

    J. Rama Rao; A. V. Mohan Rao; S. Mukherjee; R. Upadhyay; N. L. Singh; S. Agarwal; L. Chaturvedi; P. P. Singh

    1987-01-01

    Alpha-particle-induced reactions on the target elements vanadium, niobium and holmium were investigated in the energy range from 10 to 120 MeV, using the foil stack activation technique and Ge(Li) gamma-ray spectroscopy. The excitation functions of six reactions of the ( alpha , xn) type were studied, of which three reactions 51V( alpha ,n)54Mn, 165Ho( alpha ,2n)167Tm and 165Ho( alpha ,4n)165Tm

  11. Schottky barrier detectors on 4H-SiC n-type epitaxial layer for alpha particles

    NASA Astrophysics Data System (ADS)

    Chaudhuri, S. K.; Krishna, R. M.; Zavalla, K. J.; Mandal, K. C.

    2013-02-01

    Schottky barrier detectors have been fabricated on 50 ?m n-type 4H-SiC epitaxial layers grown on 360 ?m SiC substrates by depositing ?10 nm nickel contact. Current-voltage (I-V) and capacitance-voltage (C-V) measurements were carried out to investigate the Schottky barrier properties. The detectors were evaluated for alpha particle detection using a 241Am alpha source. An energy resolution of ?2.7% was obtained with a reverse bias of 100 V for 5.48 MeV alpha particles. The measured charge collection efficiency (CCE) was seen to vary as a function of bias voltage following a minority carrier diffusion model. Using this model, a diffusion length of?3.5 ?m for holes was numerically calculated from the CCE vs. bias voltage plot. Rise-time measurements of digitally recorded charge pulses for the 5.48 MeV alpha particles showed a presence of two sets of events having different rise-times at a higher bias of 200 V. A biparametric correlation scheme was successfully implemented for the first time to visualize the correlated pulse-height distribution of the events with different rise-times. Using the rise-time measurements and the biparametric plots, the observed variation of energy resolution with applied bias was explained.

  12. An investigation of alpha-like particles in the DIII-D tokamak using fusion-product diagnostics

    SciTech Connect

    Duong, H.H.

    1993-01-01

    Two important issues associated with alpha physics, the single-particle behavior and the effect of collective fast-ion-driven instabilities on fast-ion confinement, have been studied in the DIII-D tokamak using fusion product diagnostics. The single-particle behavior of alpha-like tritons and [sup 3]He ions produced in deuterium-deuterium fusion reactions is studied using the d(t,n)[alpha] and d([sup 3]he,p)[alpha] fusion reactions. Fusion-produced MeV ions exhibit classical behavior in high field (B[sub T] [ge] 1.0 T) DIII-D discharges, including the new class of [open quotes]very high[close quotes] confinement plasmas. However, discharges with strong sawtooth, fishbone, or TAE activity exhibit anomalous fusion product losses. For the high field discharges without strong MHD activity, the data imply an effective diffusion coefficient smaller than [approximately]0.1 m[sup 2]/s, but in the presence of strong MHD activity, the effective diffusion of the MeV ions exceeds 1.0 m[sup 2]/s. Collective alpha particle processes are simulated by means of neutral beam injected energetic ion minorities. Toroidicity-induced Alfven Eigenmodes (TAE) are observed in DIII-D when energetic beam ions ([approximately]75 keV) are used to destabilize the mode. Measurements of the neutron emission indicate that up to 70% of the injected power is lost during strong TAE activity. Measurements of the poloidal distribution of fast-ion losses suggest that the losses are greatest near the vessel midplane. Fast-ion losses in discharges with combined fishbones and TAE bursts are 1.5 to 2 times greater than losses in fishbone discharges without TAE activity. The scaling of fast ion losses with MHD mode amplitude exhibits no threshold in the mode amplitude, suggesting that mode-particle pumping is the dominant loss mechanism.

  13. Alpha-quartz-induced chemokine expression by rat lung epithelial cells: effects of in vivo and in vitro particle exposure.

    PubMed Central

    Driscoll, K. E.; Howard, B. W.; Carter, J. M.; Asquith, T.; Johnston, C.; Detilleux, P.; Kunkel, S. L.; Isfort, R. J.

    1996-01-01

    Chemokines are chemotactic cytokines that can play a key role in leukocyte recruitment to sites of tissue injury or infection. Previous studies have demonstrated that exposure to alpha-quartz as well as other noxious particles increases chemokine gene expression in rat lung, although the cells responsible for chemokine expression and the mechanisms underlying this response have remained unclear. The present studies demonstrate that exposure of rats to alpha-quartz induced expression of mRNA for the chemokine macrophage-inflammatory protein (MIP)-2 in epithelial cells lining the terminal bronchioles and alveolar ducts as well as macrophages and alveolar type II cells in the more distal lung. Treatment of rats with an anti-MIP-2 antiserum before alpha-quartz exposure markedly attenuated neutrophilic infiltration of the lungs demonstrating an important role for MIP-2 in alpha-quartz-induced pulmonary inflammation. In vitro exposure of primary cultures of rat alveolar type II cells or the rat alveolar type II cell line RLE-6TN to tumor necrosis factor-alpha, endotoxin, or alpha-quartz increased mRNA for MIP-2 as well as the structurally and functionally similar chemokine cytokine-induced neutrophil chemoattractant but not the chemokine MIP-1 alpha. The alpha-quartz-induced increase in epithelial MIP-2 mRNA resulted, at least in part, from increased gene transcription and was associated with the release of active MIP-2 protein. Induction of RLE-6TN MIP-2 and cytokine-induced neutrophil chemoattractant mRNA expression was not unique to alpha-quartz, being also increased by crocidolite asbestus fibers but not by titanium dioxide or MMVF-10 glass fibers. These findings indicate that epithelial cells contribute to chemokine expression in rat lung after exposure to alpha-quartz and potentially other noxious particles and suggest that alpha-quartz-activated MIP-2 expression in vivo results, at least in part, from a direct action of the particles on the lung epithelium. Images Figure 1 Figure 3 Figure 5 Figure 6 Figure 7 Figure 8 PMID:8909252

  14. Particle separator

    DOEpatents

    Hendricks, Charles D. (Livermore, CA)

    1990-01-01

    Method and apparatus (10) are provided for separating and classifying particles (48,50,56) by dispersing the particles within a fluid (52) that is upwardly flowing within a cone-shaped pipe (12) that has its large end (20) above its small end (18). Particles of similar size and shape (48,50) migrate to individual levels (A,B) within the flowing fluid. As the fluid is deflected by a plate (42) at the top end of the pipe (12), the smallest particles are collected on a shelf-like flange (40). Ever larger particles are collected as the flow rate of the fluid is increased. To prevent particle sticking on the walls (14) of the pipe (12), additional fluid is caused to flow into the pipe (12) through holes (68) that are specifically provided for that purpose. Sticking is further prevented by high frequency vibrators (70) that are positioned on the apparatus (10).

  15. Particle therapy

    SciTech Connect

    Raju, M.R.

    1993-09-01

    Particle therapy has a long history. The experimentation with particles for their therapeutic application got started soon after they were produced in the laboratory. Physicists played a major role in proposing the potential applications in radiotherapy as well as in the development of particle therapy. A brief review of the current status of particle radiotherapy with some historical perspective is presented and specific contributions made by physicists will be pointed out wherever appropriate. The rationale of using particles in cancer treatment is to reduce the treatment volume to the target volume by using precise dose distributions in three dimensions by using particles such as protons and to improve the differential effects on tumors compared to normal tissues by using high-LET radiations such as neutrons. Pions and heavy ions combine the above two characteristics.

  16. Effect of Differential Flow of Alpha Particles on Proton Pressure Anisotropy Instabilities in the Solar Wind

    NASA Astrophysics Data System (ADS)

    Podesta, John J.; Gary, S. Peter

    2011-11-01

    In the solar wind, when the effects of proton-proton Coulomb collisions are negligible, alpha particles usually flow faster than the protons in such a way that the differential alpha-proton flow velocity V d = V ? - V p is on the order of the Alfvén speed, is directed away from the Sun, and is nearly aligned with the local mean magnetic field. When this differential flow is taken into account, solutions of the hot plasma dispersion relation show that for the parallel propagating electromagnetic ion cyclotron (EMIC) instability driven by the proton temperature anisotropy T bottomp > T parp , the maximum growth rate occurs in the + V d direction and for the parallel firehose instability driven by the opposite proton temperature anisotropy T parp > T bottomp , the maximum growth rate occurs in the - V d direction. Thus, the EMIC instability preferentially generates left circularly polarized Alfvén-ion-cyclotron waves propagating away from the Sun and the parallel firehose instability preferentially generates right circularly polarized magnetosonic-whistler waves propagating toward the Sun with the maximum growth rates occurring for frequencies on the order of the proton cyclotron frequency and wavenumbers on the order of the proton inertial length. Because of the Doppler shift caused by the motion of the solar wind, both types of waves are left circularly polarized in the spacecraft frame for observations taken when the local mean magnetic field is collinear with the solar wind flow velocity. Theoretical investigation of these instabilities also shows that regions of parameter space exist where the unstable waves are generated propagating unidirectionally such as, for the EMIC instability for example, when the temperature anisotropy is small |(T bottomp /T parp ) - 1| < 1. Taken together, the above properties can explain the origin of parallel propagating electromagnetic waves recently observed near the proton inertial length in high-speed solar wind. The observed waves are most likely produced in situ by these instabilities. A remarkable property of the proposed mechanism that may be of practical importance is that the magnetic helicity of the unstable waves has the same sign no matter whether the proton temperature anisotropy (T pbottom/T ppar) - 1 is positive or negative.

  17. Determination of alpha-particle track depths in CR39 detector from their cross-sections and replica heights

    Microsoft Academic Search

    F. M. F. Ng; K. Y. Luk; D. Nikezic; K. N. Yu

    2007-01-01

    A challenging task in the application of solid-state nuclear track detectors (SSNTDs) is the measurement of depths of the tracks. One approach involves breaking and polishing the side of SSNTDs to reveal the cross-sections of the tracks for direct measurements. Recently, surface profilometry was used to measure the heights of the replicas of alpha-particle tracks to give the track depths.

  18. Study on the Sensitivity of Solid State Nuclear Track Detector (SSNTD) CR39 for Alpha-Particles Registration

    Microsoft Academic Search

    M. Gaber; A. A. Abou El-Khier; N. M. Fahmi

    1991-01-01

    The bulk etch rate, VB, in CR-39 was determined by using three methods at different etching conditions. The study was carried out for alpha-particles of energies ranging from 2.35 to 4.3 MeV at three different dissolved layers of 5.4, 7.2 and 9 ?m. Based on published REL-data, a very simple empirical formula was given to calculate REL for different ions

  19. Alpha-Particle-Driven Toroidal Alfv{acute e}n Eigenmodes in the Tokamak Fusion Test Reactor

    Microsoft Academic Search

    R. Nazikian; G. Fu; M. Bell; R. Bell; R. Budny; C. Bush; Z. Chang; Y. Chen; C. Cheng; D. Darrow; P. Efthimion; E. Fredrickson; B. Leblanc; R. Majeski; E. Mazzucato; S. Medley; J. Strachan; E. Synakowski; G. Taylor; S. Von Goeler; R. White; K. Wong; S. Zweben; S. Batha; F. Levinton; N. Gorelenkov; M. Petrov; D. Spong

    1997-01-01

    Alpha-particle-driven toroidal Alfv{acute e}n eigenmodes (TAEs) have been observed for the first time in deuterium-tritium (D-T) plasmas on the tokamak fusion test reactor (TFTR). These modes are observed 100â200ms following the end of neutral beam injection in plasmas with reduced central magnetic shear and elevated central safety factor [q(0)<1]. Mode activity is localized to the central region of the discharge

  20. Mechanism of Scintillation of Helium, Helium-Argon, and Helium-Neon Gas Mixtures Excited by Alpha Particles

    Microsoft Academic Search

    Shinzou Kubota; Tan Takahashi; Tadayoshi Doke

    1968-01-01

    An experimental investigation of the mechanism of scintillation of helium, helium-argon, and helium-neon mixtures excited by alpha particles has been performed. No detectable decrease in light yield was observed at pressures less than 3 atm when the applied electric field was increased in steps to Ep~1.0 V\\/cm Torr, where E is the electric field and p is the gas pressure.

  1. Cross sections for the production of berylium isotopes from the 880 MeV alpha-particle bombardment of carbon

    Microsoft Academic Search

    J. Lestringuez; G. M. Raisbeck; F. Yiou; R. Bernas

    1971-01-01

    The cross sections for the production of 9Be and 10Be from the 880 MeV alpha-particle bombardment of carbon have been measured to be 10.6 +\\/- 1.7 and 6.5 +\\/- 1.4 mb. These values are essentially twice the high-energy proton cross sections. It is shown that the effect of the interstellar helium on the distribution of berylium isotopes in cosmic rays

  2. Evaluation of Melt-Grown, ZnO Single Crystals for Use as Alpha-Particle Detectors

    Microsoft Academic Search

    John S. Neal; Nancy C. Giles; Xiaocheng Yang; R. Andrew Wall; K. Burak Ucer; Richard T. Williams; Dariusz J. Wisniewski; Lynn A. Boatner; Varatharajan Rengarajan; Jeff E Nause; Bill Nemeth

    2008-01-01

    As part of an ongoing investigation of the scintillation properties of zinc-oxide-(ZnO)-based scintillators, several melt-grown, ZnO single crystals have been characterized using alpha-particle excitation, infrared reflectance, and room temperature photoluminescence. The crystals, grown by Cermet, Inc., using an oxygen-pressurized melt-growth process, were doped with Group 1 elements (Li), Group 2 elements (Mg), Group 3 elements (Ga, In) and lanthanides (Gd,

  3. Cytogenetic and molecular genetic analysis of tumorigenic human bronchial epithelial cells induced by radon alpha particles.

    PubMed

    Weaver, D A; Hei, T K; Hukku, B; McRaven, J A; Willey, J C

    1997-06-01

    To establish a cell culture model for lung carcinogenesis, independent populations of the human papillomavirus 18-immortalized human bronchial epithelial cell line BEP2D were treated with high linear energy transfer radon-simulated alpha-particles, expanded and xenotransplanted into Nu/Nu mice. Six independent cell lines were established from tumors that developed from three separate radiation treatments as follows: treatment (Tx) 1 (30 cGy--two doses), H2BT, Tx 2 (30 cGy--single dose), R30T1L, R30T2 and R30T3L, Tx 3 (30 cGy--single dose), H1ATN and H1ATBA1. Cytogenetic analysis revealed common changes in all tumor lines: loss of the Y chromosome (ch), one of three copies of ch8, one of three copies of ch14, and one of two copies of ch4p16-pter and ch11p15-pter. Analysis of polymerase chain reaction-amplified short tandem repeats of informative loci confirmed the loss of chY in all lines and loss of heterozygosity (LOH) at eight loci spanning the length of ch8 in all lines from Tx's 1 and 2. Our data support previous studies indicating the presence of tumor suppressor genes on ch8. LOH also was confirmed on ch14 at locus D14S306 in all cell lines from Tx 2 and in one of two lines from Tx 3. This region, 14q12-q13, may contain changes in one of the five known somatostatin receptor genes (SSTR1). No LOH was detected at any of the informative loci tested for on ch4 or ch11. PMID:9214610

  4. Production of TNF-alpha and bone resorbing activity by macrophages in response to different types of bone cement particles.

    PubMed

    Ingham, E; Green, T R; Stone, M H; Kowalski, R; Watkins, N; Fisher, J

    2000-05-01

    We have compared the capacity of clinically relevant wear debris from seven different cement types to activate macrophages to produce TNF-alpha, IL-1beta, IL-6 and bone resorbing activity in vitro. The bone cements were: CMW 1 original (PMMA only); CMW 1RO (1 microm BaSO4; 9.2%); CMW copolymer bone cement 1 (10 microm BaSO4; 10%); CMW copolymer bone cement 2 (1 microm BaSO4; 10%); Palacos R (10 microm ZrO2; 15.6%); CMW Calcium phosphate cement 20% (10 microm tri-calcium phosphate; 20%) and CMW calcium phosphate cement 30% (10 microm tri-calcium phosphate; 30%). Cement debris was produced aseptically using a simple configuration wear test. The majority of particles were in the size range 0.1-0.5 microm for each cement type. The cement particles were co-cultured with the U937 macrophage cell line at ratios of 10 and 100 microm3 particle volumes to macrophage cell numbers for 24 h. At the 10:1 ratio the particles had no effect on the cells. At the 100:1 ratio, the major cytokine produced was TNF-alpha and there were no statistical differences between the different types of cement debris. The bone resorption activity of the co-culture supernatants was significantly greater than the control (U937 cells without particles) for particles of CMW 1RO, CMW copolymer bone cement 1, CMW copolymer bone cement 2 and Palacos R (P < 0.05, ANOVA). However there were no statistical differences between the levels of bone resoprtion evoked by these four cement types. The CMW1 original and CMW calcium phosphate containing cements failed to induce the macrophages to elaborate bone resorption activity at the 100:1 ratio. These data suggest that the addition of radio-opaque additives to bone cement may increase the capacity of the debris to induce osteolysis. PMID:10768752

  5. Use of neutralized knock-on ion fluxes for alpha-particle confinement studies

    NASA Astrophysics Data System (ADS)

    Nesenevich, V. G.; Afanasyev, V. I.; Goncharov, P. R.; Mironov, M. I.; Petrov, M. P.; Petrov, S. Ya

    2014-12-01

    One of the objectives of neutral particle diagnostics on large tokamaks exploring DT plasma is to measure the distribution functions of fast deuterium (D) and tritium (T) ions in a suprathermal energy range. High energy tails in D,T-ion energy distributions (so-called knock-on ions) appear as a result of close elastic collisions between thermal fuel ions and fusion ?-particles. The knock-on ion density depends directly on the density and energy distribution of the ?-particles. Therefore measurements of the neutralized knock-on D,T-ion fluxes escaping from the plasma volume can provide information on the ?-particle confinement in DT plasma. This paper presents the results of a numerical simulation for the neutralized fast D,T-ion fluxes in the case of ITER fusion plasma. Feasible experimental measurements of the fluxes are considered with respect to the neutral particle diagnostics. We will show that the diagnostics can provide information on the confinement properties of fast ions in DT fusion plasma.

  6. Very High Efficiency, Miniaturized, Long-Lived Alpha Particle Power Source Using Diamond Devices for Extreme Space Environments

    NASA Technical Reports Server (NTRS)

    Kolawa, Elizabeth A. (Inventor); Patel, Jagdishbhai U. (Inventor); Fleurial, Jean-Pierre (Inventor)

    2004-01-01

    A power source that converts a-particle energy into electricity by coulomb collision in doped diamond films is described. Alpha particle decay from curium-244 creates electron-hole pairs by free- ing electrons and holes inside the crystal lattice in N- and P-doped diamond films. Ohmic contacts provide electrical connection to an electronic device. Due to the built-in electric field at the rectifying junction across the hT- and P-doped diamond films, the free electrons are constrained to traveling in generally one direction. This one direction then supplies electrons in a manner similar to that of a battery. The radioactive curium layer may be disposed on diamond films for even distribution of a-particle radiation. The resulting power source may be mounted on a diamond substrate that serves to insulate structures below the diamond substrate from a-particle emission. Additional insulation or isolation may be provided in order to prevent damage from a-particle collision. N-doped silicon may be used instead of N-doped diamond.

  7. AIRBORNE PARTICLES

    EPA Science Inventory

    The document summarizes the literature on airborne particles related to effects on man and his environment for consideration of the Environmental Protection Agency in updating the information in the Air Quality Criteria for Particulate Matter. Specific particles such as lead, ars...

  8. Particle preconcentrator

    SciTech Connect

    Linker, Kevin L. (Albuquerque, NM); Conrad, Frank J. (Russellville, SC); Custer, Chad A. (Albuquerque, NM); Rhykerd, Jr., Charles L. (Albuquerque, NM)

    2000-01-01

    An apparatus and method for preconcentrating particles and vapors. The preconcentrator apparatus permits detection of highly diluted amounts of particles in a main gas stream, such as a stream of ambient air. A main gas stream having airborne particles entrained therein is passed through a pervious screen. The particles accumulate upon the screen, as the screen acts as a sort of selective particle filter. The flow of the main gas stream is then interrupted by diaphragm shutter valves, whereupon a cross-flow of carrier gas stream is blown parallel past the faces of the screen to dislodge the accumulated particles and carry them to a particle or vapor detector, such as an ion mobility spectrometer. The screen may be heated, such as by passing an electrical current there through, to promote desorption of particles therefrom during the flow of the carrier gas. Various types of screens are disclosed. The apparatus and method of the invention may find particular utility in the fields of narcotics, explosives detection and chemical agents.

  9. Particle preconcentrator

    DOEpatents

    Linker, Kevin L.; Conrad, Frank J.; Custer, Chad A.; Rhykerd, Jr., Charles L.

    2005-09-20

    An apparatus and method for preconcentrating particles and vapors. The preconcentrator apparatus permits detection of highly diluted amounts of particles in a main gas stream, such as a stream of ambient air. A main gas stream having airborne particles entrained therein is passed through a pervious screen. The particles accumulate upon the screen, as the screen acts as a sort of selective particle filter. The flow of the main gas stream is then interrupted by diaphragm shutter valves, whereupon a cross-flow of carrier gas stream is blown parallel past the faces of the screen to dislodge the accumulated particles and carry them to a particle or vapor detector, such as an ion mobility spectrometer. The screen may be heated, such as by passing an electrical current there through, to promote desorption of particles therefrom during the flow of the carrier gas. Various types of screens are disclosed. The apparatus and method of the invention may find particular utility in the fields of narcotics, explosives detection and chemical agents.

  10. Particle preconcentrator

    SciTech Connect

    Linker, Kevin L. (Albuquerque, NM); Conrad, Frank J. (Russellville, NM); Custer, Chad A. (Albuquerque, NM); Rhykerd, Jr., Charles L. (Albuquerque, NM)

    1998-01-01

    An apparatus and method for preconcentrating particles and vapors. The preconcentrator apparatus permits detection of highly diluted amounts of particles in a main gas stream, such as a stream of ambient air. A main gas stream having airborne particles entrained therein is passed through a pervious screen. The particles accumulate upon the screen, as the screen acts as a sort of selective particle filter. The flow of the main gas stream is then interrupted by diaphragm shutter valves, whereupon a cross-flow of carrier gas stream is blown parallel past the faces of the screen to dislodge the accumulated particles and carry them to a particle or vapor detector, such as an ion mobility spectrometer. The screen may be heated, such as by passing an electrical current there through, to promote desorption of particles therefrom during the flow of the carrier gas. Various types of screens are disclosed. The apparatus and method of the invention may find particular utility in the fields of narcotics, explosives detection and chemical agents.

  11. Particle preconcentrator

    SciTech Connect

    Linker, K.L.; Conrad, F.J.; Custer, C.A.; Rhykerd, C.L. Jr

    2000-07-11

    An apparatus and method are disclosed for preconcentrating particles and vapors. The preconcentrator apparatus permits detection of highly diluted amounts of particles in a main gas stream, such as a stream of ambient air. A main gas stream having airborne particles entrained therein is passed through a previous screen. The particles accumulate upon the screen, as the screen acts as a sort of selective particle filter. The flow of the main gas stream is then interrupted by diaphragm shutter valves, whereupon a cross-flow of carrier gas stream is blown parallel past the faces of the screen to dislodge the accumulated particles and carry them to a particle or vapor detector, such as an ion mobility spectrometer. The screen may be heated, such as by passing an electrical current there through, to promote desorption of particles therefrom during the flow of the carrier gas. Various types of screens are disclosed. The apparatus and method of the invention may find particular utility in the fields of narcotics, explosives detection and chemical agents.

  12. Particle preconcentrator

    DOEpatents

    Linker, K.L.; Conrad, F.J.; Custer, C.A.; Rhykerd, C.L. Jr.

    1998-12-29

    An apparatus and method are disclosed for preconcentrating particles and vapors. The preconcentrator apparatus permits detection of highly diluted amounts of particles in a main gas stream, such as a stream of ambient air. A main gas stream having airborne particles entrained therein is passed through a pervious screen. The particles accumulate upon the screen, as the screen acts as a sort of selective particle filter. The flow of the main gas stream is then interrupted by diaphragm shutter valves, whereupon a cross-flow of carrier gas stream is blown parallel past the faces of the screen to dislodge the accumulated particles and carry them to a particle or vapor detector, such as an ion mobility spectrometer. The screen may be heated, such as by passing an electrical current there through, to promote desorption of particles therefrom during the flow of the carrier gas. Various types of screens are disclosed. The apparatus and method of the invention may find particular utility in the fields of narcotics, explosives detection and chemical agents. 3 figs.

  13. The emission probabilities of long range alpha particles from even-even 244-252Cm isotopes

    NASA Astrophysics Data System (ADS)

    Santhosh, K. P.; Krishnan, Sreejith; Priyanka, B.

    2014-10-01

    The alpha accompanied cold ternary fission of even-even 244Cm, 246Cm, 248Cm, 250Cm and 252Cm isotopes has been studied by taking the interacting barrier as the sum of the Coulomb and proximity potential with the fragments in equatorial configuration. The favorable fragment combinations are obtained from the cold reaction valley plot and by calculating the relative yield for the charge minimized fragments. In the alpha accompanied ternary fission of the 244Cm isotope, the highest yield is found for the fragment combination 110Ru+4He+130Sn, which possess near doubly magic nuclei 130Sn. For the ternary fission of 246Cm, 248Cm, 250Cm and 252Cm isotopes with 4He as the light charged particle, the highest yield is obtained for the fragment combination with doubly magic nuclei 132Sn as the heavier fragment. The emission probabilities and kinetic energies of long range alpha particles have been computed for the 242,244,246,248Cm isotopes and are found to be in good agreement with the experimental data. The relative yields for the 4He accompanied ternary fission (equatorial and collinear) of 242-252Cm isotopes are compared with the corresponding yield for binary fission. The effect of deformation and orientation of fragments in the 4He accompanied ternary fission of 244-252Cm isotopes are studied. Our study reveals that the ground state deformation has as an important role in the alpha accompanied ternary fission as that of the shell effect.

  14. The emission probabilities of long range alpha particles from even-even 244-252Cm isotopes

    E-print Network

    K. P. Santhosh; Sreejith Krishnan; B. Priyanka

    2014-09-02

    The alpha accompanied cold ternary fission of even-even 244Cm, 246Cm, 248Cm, 250Cm and 252Cm isotopes have been studied by taking the interacting barrier as the sum of Coulomb and proximity potential with the fragments in equatorial configuration. The favorable fragment combinations are obtained from the cold reaction valley plot and by calculating the relative yield for the charge minimized fragments. In the alpha accompanied ternary fission of 244Cm isotope, the highest yield is found for the fragment combination 110Ru+4He+130Sn, which possess near doubly magic nuclei 130Sn. For the ternary fission of 246Cm, 248Cm, 250Cm and 252Cm isotopes with 4He as light charged particle, the highest yield is obtained for the fragment combination with doubly magic nuclei 132Sn as the heavier fragment. The emission probabilities and kinetic energies of long range alpha particle have been computed for the 242,244,246,248Cm isotopes and are found to be in good agreement with the experimental data. The relative yields for the 4He accompanied ternary fission (equatorial and collinear) of 242-252Cm isotopes are compared with the corresponding yield for binary fission. The effect of deformation and orientation of fragments in the 4He accompanied ternary fission of 244-252Cm isotopes are studied. Our study reveals that the ground state deformation has an important role in the alpha accompanied ternary fission as that of shell effect.

  15. Alpha-particle-induced luminescence of rare-earth-doped Y{sub 2}O{sub 3} nanophosphors

    SciTech Connect

    Cress, Cory D. [NanoPower Research Laboratories at the Rochester Institute of Technology, 85 Lomb Memorial Road, Rochester, NY 14623 (United States); Microsystems Engineering Program at the Rochester Institute of Technology, Rochester, NY 14623 (United States)], E-mail: cory_cress@hotmail.com; Redino, Christopher S. [NanoPower Research Laboratories at the Rochester Institute of Technology, 85 Lomb Memorial Road, Rochester, NY 14623 (United States)], E-mail: csr8932@rit.edu; Landi, Brian J. [NanoPower Research Laboratories at the Rochester Institute of Technology, 85 Lomb Memorial Road, Rochester, NY 14623 (United States)], E-mail: bjlsps@rit.edu; Raffaelle, Ryne P. [NanoPower Research Laboratories at the Rochester Institute of Technology, 85 Lomb Memorial Road, Rochester, NY 14623 (United States); Microsystems Engineering Program at the Rochester Institute of Technology, Rochester, NY 14623 (United States)], E-mail: rprsps@rit.edu

    2008-08-15

    The feasibility of utilizing Y{sub 2}O{sub 3}:Tb{sup 3+} and Y{sub 2}O{sub 3}:Eu{sup 3+} as radioluminescent nanophosphors under alpha-particle excitation is investigated. Materials synthesized by the urea homogeneous precipitation method were characterized using scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray diffraction (XRD). The XRD analysis of as-produced precipitates and nanophosphors fired at temperatures ranging from 950 to 1100 deg. C indicated the presence of highly crystalline cubic Y{sub 2}O{sub 3} with crystallite sizes of {approx}40 nm. SEM and TEM analysis revealed that particles with average diameters of {approx}200 nm and comprised of {approx}40 nm grains were obtained. High-resolution radioluminescence and photoluminescence spectra were used to investigate the unwanted radioluminescence saturation effects associated with the high ionization rate of alpha-particles. Additionally, the radioluminescence intensity as a function of rare-earth ion dopant concentration is investigated for these materials under alpha-particle excitation. The prospect for utilizing these materials as intermediate absorbers in indirect-conversion radioisotope batteries is discussed. - Graphical abstract: The photoluminescence and radioluminesce emission from rare-earth doped Y{sub 2}O{sub 3} nanophosphors are being investigated. Below is a representative image of the photoluminescence from Y{sub 2}O{sub 3}:Eu{sup 3+} (left) and Y{sub 2}O{sub 3}:Tb{sup 3+} (right) under UV-light excitation.

  16. Dynamic radioactive particle source

    DOEpatents

    Moore, Murray E.; Gauss, Adam Benjamin; Justus, Alan Lawrence

    2012-06-26

    A method and apparatus for providing a timed, synchronized dynamic alpha or beta particle source for testing the response of continuous air monitors (CAMs) for airborne alpha or beta emitters is provided. The method includes providing a radioactive source; placing the radioactive source inside the detection volume of a CAM; and introducing an alpha or beta-emitting isotope while the CAM is in a normal functioning mode.

  17. Particle astrophysics

    SciTech Connect

    Sadoulet, B. (Univ. of California, Berkeley (United States)); Cronin, J.W. (Univ. of Chicago, IL (United States))

    1991-04-01

    Particle astrophysics emerged in the 1980s as a new field at the junction of high-energy astrophysics, cosmology and particle physics. This new experimental, observational and theoretical discipline concerns itself, for example, with the nature of dark matter; the detection of neutrinos from the Sun and from supernovae; the evidence for powerful acceleration mechanisms in the vicinity of neutron stars; and the suggestion that quantum fluctuation and topological singularities in the first moments of the cosmos played a role in the formation of the great structures we see today stretching over hundreds of millions of light-years. The extensive-air-shower array recently built in Dugway, Utah by a Chicago-Michigan collaboration, illustrates the symbiosis of particle physics and astronomy. Although particle astrophysics received some consideration in the previous surveys of astronomy and astrophysics, the present survey is the first to avail itself of a special panel on particle astrophysics. This panel was assigned three subfields: particle physics and cosmology; particle physics and the physics of stars; and high-energy astrophysics, including, for example, the presence of ultrahigh-energy gammas in cosmic rays.

  18. The Radiation Chemistry of Aqueous Solutions. I. The Effect of Changing Linear Energy Transfer Along a Polonium alpha-Particle Track

    Microsoft Academic Search

    E. Collinson; F. S. Dainton; J. Kroh

    1962-01-01

    Absolute G values for chemical change when various aqueous solutions are irradiated with alpha-particles from an external polonium source have been determined for different fractions (x) of the alpha-particle track spent within the solution. G(Fe3+) for an aerated solution containing 1 mM ferrous ions and 0\\\\cdot1 N sulphuric acid decreases from 5\\\\cdot0 at x = 0\\\\cdot02 through a minimum value

  19. High-resolution alpha-particle spectroscopy with an hybrid SiC\\/GaN detector\\/front-end detection system

    Microsoft Academic Search

    A. Pullia; G. Bertuccio; D. Maiocchi; S. Caccia; F. Zocca

    2007-01-01

    An alpha-particle spectrometer has been assembled, consisting of an epitaxial 50 mum thick 4H silicon carbide detector connected to a gallium nitride HEMT used as input transistor of the front-end electronics. The depleted layer of the SiC diode detector was sufficient to stop all alpha particles of the used emitter in the 4.8-MeV to 5.8-MeV energy range. An excellent energy

  20. Studies on the variation of the track etch rate along alpha particle trajectories in CR39

    Microsoft Academic Search

    B Dörschel; H Hartmann; K Kadner; P Rö?ler

    1995-01-01

    At the beginning of the etching process a constant track etch rate can be assumed. In deeper detector layers, however, the etch rate varies drastically along the particle trajectories. Consequently, the indirect determination of the track etch rate by measuring the etch pit diameters on the detector surface does not yield correct results. Therefore, a method for the direct measurement

  1. Polymer Particles

    NASA Astrophysics Data System (ADS)

    Okubo, Masayoshi

    In this special volume on polymer particles, recent trends and developments in the synthesis of nano- to micron-sized polymer particles by radical polymerization (Emulsion, Miniemulsion, Microemulsion, and Dispersion Polymerizations) of vinyl monomers in environmentally friendly heterogeneous aqueous and supercritical carbon dioxide fluid media are reviewed by prominent worldwide researchers. In addition to the important challenges and possibilities with regards to design and preparation of functionalized polymer particles of controlled size, the topics described are of great current interest due to the increased awareness of environmental issues.

  2. Alpha track analysis and fission track analysis for localizing actinide-bearing micro-particles in the Yenisey River bottom sediments

    Microsoft Academic Search

    I. E. Vlasova; St. N. Kalmykov; Yu. V. Konevnik; S. G. Simakin; I. S. Simakin; A. Yu. Anokhin; Yu. A. Sapozhnikov

    2008-01-01

    Distribution of actinides in bottom sediment and flood land soil cores collected from the Yenisey River near the Krasnoyarsk Mining and Chemical Combine (MCC) were analyzed. Actinide-bearing micro-particles were localized using alpha track analysis (ATA) and fission track analysis (FTA). Different types of radioactive micro-particles were found by analysis of the ratios of fission tracks to ?-tracks from single particles.

  3. Selective gene amplification in mammalian cells after exposure to 60Co gamma rays, 241Am alpha particles, or uv light

    SciTech Connect

    Luecke-Huhle, C.P.; Pech, M.; Herrlich, P.

    1986-06-01

    Simian Virus 40 wild type (SV40)-transformed Chinese hamster embryo cells (Co631) contain about five viral copies integrated per cell genome. These SV40 sequences were used as endogenous indicator genes to study the response of mammalian cells to radiation at the gene level. An increase in copy number was detected by dispersed cell blotting and Southern analysis in combination with specific DNA hybridization. All types of radiation tested induce a 15- to 25-fold amplification of SV40 sequences without producing intact virus. The amplification is dose dependent and increases with time after irradiation: a maximum effect is observed at Day 3 after alpha particle or uv exposure and at Day 6 after gamma-ray exposure. A RBE of 6 can be calculated for alpha particles if amplification rates at Day 3 are compared. However, when the maximum effect is considered independent of time, no difference between different types of radiation is observed. Southern blots of genomic DNA show that not all integrated SV40 sequences are amplified upon radiation. Amplified sequences are found either in restriction fragments of relatively high molecular weight or in unit size fragments. SV40 amplification is selective in that the amplification of other genes, e.g., of alpha-actin, dhfr (dihydrofolate reductase), and of two oncogenes of the ras family (Kirsten ras and Harvey ras), was below detection level.

  4. Particle Detection

    NSDL National Science Digital Library

    2012-12-06

    This is an activity about the the functioning of the Interstellar Boundary Explorer, or IBEX, spacecraft. Learners will participate in an interactive demonstration to illustrate how the IBEX spacecraft uses its particle detectors to collect and sort particles that come from the boundary of the Solar System. This activity complements other IBEX informal education materials. An instructional video explaining how to facilitate this activity is available: http://bit.ly/YqwWCd.

  5. Auroral particles

    NASA Technical Reports Server (NTRS)

    Evans, David S.

    1987-01-01

    The problems concerning the aurora posed prior to the war are now either solved in principle or were restated in a more fundamental form. The pre-war hypothesis concerning the nature of the auroral particles and their energies was fully confirmed, with the exception that helium and oxygen ions were identified as participating in the auroral particle precipitation in addition to the protons. The nature of the near-Earth energization processes affecting auroral particles was clarified. Charged particle trajectories in various electric field geometries were modeled. The physical problems have now moved from determining the nature and geometry of the electric fields, which accelerate charged particles near the Earth, to accounting for the existence of these electric fields as a natural consequence of the solar wind's interaction with Earth. Ultimately the reward in continuing the work in auroral and magnetospheric particle dynamics will be a deeper understanding of the subtleties of classical electricity and magnetism as applied to situations not blessed with well-defined and invariant geometries.

  6. TEST PROCEDURE FOR GROSS ALPHA PARTICLE ACTIVITY IN DRINKING WATER: INTERLABORATORY COLLABORATIVE STUDY

    EPA Science Inventory

    Gross alpha activity values were calculated with four different alpha emitting radionuclide standard counting efficiencies to see which standard was best for gross alpha activity determinations. Thorium-230, a pure alpha emitter, appeared to be the best standard for gross alpha c...

  7. Radioimmunotherapy of Breast Cancer Metastases with Alpha-Particle-emitter 225Ac: Comparing Efficacy with 213Bi, 90Y

    PubMed Central

    Song, Hong; Hobbs, Robert F.; Vajravelu, Ravy; Huso, David L.; Esaias, Caroline; Apostolidis, Christos; Morgenstern, Alfred; Sgouros, George

    2009-01-01

    Alpha-particles are suitable to treat cancer micrometastases because of their short range and very high linear energy transfer. Alpha-particle-emitter 213Bi based radioimmunotherapy has shown efficacy in a variety of metastatic animal cancer models, such as breast, ovarian, prostate cancer and leukemia. Its clinical implementation, however, is challenging due to the limited supply of 225Ac, the high technical requirement to prepare radioimmunoconjugate with very short half-life (T1/2=45.6 mins) on site and prohibitive cost. In this study, we investigated the efficacy of the alpha-particle-emitter 225Ac, parent of 213Bi, in a mouse model of breast cancer metastases. A single administration of 225Ac (400 nCi) labeled anti-rat HER-2/neu monoclonal antibody (7.16.4) completely eradicated breast cancer lung micrometastases in about 67% of HER-2/neu transgenic mice and led to long-term survival of these mice for up to one year. Treatment with 225Ac-7.16.4 is significantly more effective than 213Bi-7.16.4 (120 ?Ci) (median survival = 61 days, P=0.001), and 90Y-7.16.4 (120 ?Ci) (median survival = 50 days, P<0.001), as well as untreated control (median survival = 41 days, P=0.0001). Dosimetric analysis showed that 225Ac treated metastases received a total dose of 9.6 Gy, significantly higher than 2.0 Gy from 213Bi and 2.4 Gy from 90Y. Biodistribution studies revealed that 225Ac daughters, 221Fr and 213Bi, accumulated in kidneys and probably contributed to the long-term renal toxicity observed in surviving mice. These data suggest 225Ac labeled anti-HER-2/neu monoclonal antibody could significantly prolong survival in HER-2/neu-positive metastatic breast cancer patients. PMID:19920193

  8. Radioimmunotherapy of breast cancer metastases with alpha-particle emitter 225Ac: comparing efficacy with 213Bi and 90Y.

    PubMed

    Song, Hong; Hobbs, Robert F; Vajravelu, Ravy; Huso, David L; Esaias, Caroline; Apostolidis, Christos; Morgenstern, Alfred; Sgouros, George

    2009-12-01

    alpha-Particles are suitable to treat cancer micrometastases because of their short range and very high linear energy transfer. alpha-Particle emitter (213)Bi-based radioimmunotherapy has shown efficacy in a variety of metastatic animal cancer models, such as breast, ovarian, and prostate cancers. Its clinical implementation, however, is challenging due to the limited supply of (225)Ac, high technical requirement to prepare radioimmunoconjugate with very short half-life (T(1/2) = 45.6 min) on site, and prohibitive cost. In this study, we investigated the efficacy of the alpha-particle emitter (225)Ac, parent of (213)Bi, in a mouse model of breast cancer metastases. A single administration of (225)Ac (400 nCi)-labeled anti-rat HER-2/neu monoclonal antibody (7.16.4) completely eradicated breast cancer lung micrometastases in approximately 67% of HER-2/neu transgenic mice and led to long-term survival of these mice for up to 1 year. Treatment with (225)Ac-7.16.4 is significantly more effective than (213)Bi-7.16.4 (120 microCi; median survival, 61 days; P = 0.001) and (90)Y-7.16.4 (120 microCi; median survival, 50 days; P < 0.001) as well as untreated control (median survival, 41 days; P < 0.0001). Dosimetric analysis showed that (225)Ac-treated metastases received a total dose of 9.6 Gy, significantly higher than 2.0 Gy from (213)Bi and 2.4 Gy from (90)Y. Biodistribution studies revealed that (225)Ac daughters, (221)Fr and (213)Bi, accumulated in kidneys and probably contributed to the long-term renal toxicity observed in surviving mice. These data suggest (225)Ac-labeled anti-HER-2/neu monoclonal antibody could significantly prolong survival in HER-2/neu-positive metastatic breast cancer patients. PMID:19920193

  9. Proton-nucleus optical potential in the alpha-particle model

    NASA Astrophysics Data System (ADS)

    Tan, Zhen-Qiang; Ruan, Wen-Ying

    1990-07-01

    In this paper, by using a phenomenological amplitude fitted with p- 4He elastic scattering data, and on the basis of the ?-particle model of the nucleus, a theoretical proton-nucleus optical potential is constructed. With this potential, the differential cross section, the polarization and the spin-rotation parameter for p- 12C elastic scattering are calculated at Tp = 200 and 398 MeV. The theoretical calculations are in good agreement with the experimental data.

  10. Minimum ionizing and alpha particles detectors based on epitaxial semiconductor silicon carbide

    Microsoft Academic Search

    F. Nava; P. Vanni; M. Bruzzi; S. Lagomarsino; S. Sciortino; G. Wagner; C. Lanzieri

    2004-01-01

    The relatively high value of the energy required to produce an electron-hole pair in silicon carbide, SiC, by a minimum ionizing particle (MIP) against the value for Si, imposes severe constrains in the crystallographic quality, the thickness and the doping concentration of the SiC epitaxial layer used as the detection medium. In this work, a 40 ?m thick 4 H-SiC

  11. Alpha-particle formation and decay rates from Skyrme-HFB wave functions

    NASA Astrophysics Data System (ADS)

    Ward, D. E.; Carlsson, B. G.; Åberg, S.

    2014-05-01

    ? decay is treated microscopically, where the unstable mother nucleus and residual daughter nucleus are described using Hartree-Fock-Bogoliubov (HFB) wave functions, obtained with the Skyrme effective interaction. From these wave functions the amplitude for forming ? particles in the mother nucleus is computed. Two different Skyrme parametrizations with different pairing properties are compared, and we find good agreement with experiment for relative decay rates in both cases. The absolute values of the decay rates are underestimated.

  12. Investigation on polycrystalline CVD diamond-based alpha-particle detectors

    Microsoft Academic Search

    S. G Wang; Q Zhang; S. F Yoon; J Ahn

    2002-01-01

    In this paper, ?-particle detectors have been fabricated using good quality polycrystalline CVD diamond thin films deposited by HFCVD technique. Coplanar electrical contacts with interelectrode spacing of 100?m were prepared on the growth side of the CVD diamond film using lift-off technology. The detector performance has been tested with a 241Am source with a characteristic energy of 5.5MeV at room

  13. Alpha-particle capture reactions in inverse kinematics relevant to p-process nucleosynthesis

    NASA Astrophysics Data System (ADS)

    Uji?, P.; Lagoyannis, A.; Mertzimekis, T. J.; de Oliveira Santos, F.; Harissopulos, S.; Demetriou, P.; Perrot, L.; Stodel, Ch.; Saint-Laurent, M.-G.; Kamalou, O.; Lefebvre-Schuhl, A.; Spyrou, A.; Amthor, M. A.; Grevy, S.; Caceres, L.; Koivisto, H.; Laitinen, M.; Uusitalo, J.; Julin, R.

    2011-10-01

    The first feasibility study of an ?-particle capture reaction in inverse kinematics at energies relevant to the p process was performed at the Wien Filter of the LISE spectrometer at GANIL. Hereby, the 4He(78Kr,?)82Sr reaction was investigated using as target an 4He-implanted thin Al foil. The analysis of the data has shown that the determination of (?,?) reaction cross sections at rather low energies around 2 MeV/u in inverse kinematics is indeed feasible regarding the high rejection rate of the primary beam, which in the present work was better than a factor of 109. However, the expected position of the recoils of interest was completely masked by particles of currently unknown origin that could hardly be attributed to scattering of the primary beam. The most probable explanation for the origin of these "pollutants" could be microscopic dust particles of 10 ?m diameter and less, that are extremely difficult to avoid in standard experimental conditions. Hence, the use of a gas-jet target instead of a solid one is compulsory.

  14. The role of nuclear reactions and {alpha}-particle transport in the dynamics of inertial confinement fusion capsules

    SciTech Connect

    Garnier, Josselin [Laboratoire de Probabilites et Modeles Aleatoires and Laboratoire Jacques-Louis Lions, Universite Paris VII, 2 Place Jussieu, 75251 Paris Cedex 05 (France); Cherfils-Clerouin, Catherine [Commissariat a l'Energie Atomique, Direction des Applications Militaires, Boite Postale 12, 91680 Bruyeres le Chatel (France)

    2008-10-15

    This paper is devoted to the study of the deceleration phase of inertial confinement capsules. The purpose is to obtain a zero-dimensional model that has the form of a closed system of ordinary differential equations for the main hydrodynamic quantities. The model takes into account the energy released by nuclear reactions, a nonlocal model for the {alpha}-particle energy deposition process, and radiation loss by electron bremsstrahlung. The asymptotic analysis is performed in the case of a strong temperature dependence of the thermal conductivity. We finally study the beginning of the expansion phase after stagnation to derive an ignition criterion.

  15. Development of a He- and He0 beam source for alpha particle measurement in a burning plasma.

    PubMed

    Tanaka, N; Sasao, M; Terai, K; Okamoto, A; Kitajima, S; Yamaoka, H; Wada, M

    2012-02-01

    Proof of principle experiments of neutral helium beam production for alpha particle diagnostics was carried out on a test stand. Negative helium ions were produced in the Li charge exchange cell, in which stable and long time operation was possible. He(-) beam was accelerated to 157 keV. Finally, He(0) beam was successfully produced after the flight in the drift-tube through the auto-electron-detachment process from He(-) to He(0). A neutral beam detector using a pyroelectric device was also developed to measure He(0) beam intensity. The metastable component in the neutral helium beam was found to be less than 2%. PMID:22380272

  16. 1.5D Quasilinear Model for Alpha Particle-TAE Interaction in ARIES ACT-I

    SciTech Connect

    K. Ghantous, N.N. Gorelenkov, C. Kessel, F. Poli

    2013-01-30

    We study the TAE interaction with alpha particle fusion products in ARIES ACT-I using the 1.5D quasilinear model. 1.5D uses linear analytic expressions for growth and damping rates of TAE modes evaluated using TRANSP pro les to calculates the relaxation of pressure pro les. NOVA- K simulations are conducted to validate the analytic dependancies of the rates, and to normalize their absolute value. The low dimensionality of the model permits calculating loss diagrams in large parameter spaces.

  17. Pileup Per Particle Identification

    E-print Network

    Daniele Bertolini; Philip Harris; Matthew Low; Nhan Tran

    2014-09-30

    We propose a new method for pileup mitigation by implementing "pileup per particle identification" (PUPPI). For each particle we first define a local shape $\\alpha$ which probes the collinear versus soft diffuse structure in the neighborhood of the particle. The former is indicative of particles originating from the hard scatter and the latter of particles originating from pileup interactions. The distribution of $\\alpha$ for charged pileup, assumed as a proxy for all pileup, is used on an event-by-event basis to calculate a weight for each particle. The weights describe the degree to which particles are pileup-like and are used to rescale their four-momenta, superseding the need for jet-based corrections. Furthermore, the algorithm flexibly allows combination with other, possibly experimental, probabilistic information associated with particles such as vertexing and timing performance. We demonstrate the algorithm improves over existing methods by looking at jet $p_T$ and jet mass. We also find an improvement on non-jet quantities like missing transverse energy.

  18. Redefining Relative Biological Effectiveness in the Context of the EQDX Formalism: Implications for Alpha-Particle Emitter Therapy

    PubMed Central

    Hobbs, Robert F.; Howell, Roger W.; Song, Hong; Baechler, Sébastien; Sgouros, George

    2014-01-01

    Alpha-particle radiopharmaceutical therapy (?RPT) is currently enjoying increasing attention as a viable alternative to chemotherapy for targeting of disseminated micrometastatic disease. In theory, ?RPT can be personalized through pre-therapeutic imaging and dosimetry. However, in practice, given the particularities of ?-particle emissions, a dosimetric methodology that accurately predicts the thresholds for organ toxicity has not been reported. This is in part due to the fact that the biological effects caused by ?-particle radiation differ markedly from the effects caused by traditional external beam (photon or electron) radiation or ?-particle emitting radiopharmaceuticals. The concept of relative biological effectiveness (RBE) is used to quantify the ratio of absorbed doses required to achieve a given biological response with alpha particles versus a reference radiation (typically a beta emitter or external beam radiation). However, as conventionally defined, the RBE varies as a function of absorbed dose and therefore a single RBE value is limited in its utility because it cannot be used to predict response over a wide range of absorbed doses. Therefore, efforts are underway to standardize bioeffect modeling for different fractionation schemes and dose rates for both nuclear medicine and external beam radiotherapy. Given the preponderant use of external beams of radiation compared to nuclear medicine in cancer therapy, the more clinically relevant quantity, the 2 Gy equieffective dose, EQD2(?/?), has recently been proposed by the ICRU. In concert with EQD2(?/?), we introduce a new, redefined RBE quantity, named RBE2(?/?), as the ratio of the two linear coefficients that characterize the ? particle absorbed dose-response curve and the low-LET megavoltage photon 2 Gy fraction equieffective dose-response curve. The theoretical framework for the proposed new formalism is presented along with its application to experimental data obtained from irradiation of a breast cancer cell line. Radiobiological parameters are obtained using the linear quadratic model to fit cell survival data for MDA-MB-231 human breast cancer cells that were irradiated with either ? particles or a single fraction of low-LET 137Cs ? rays. From these, the linear coefficient for both the biologically effective dose (BED) and the EQD2(?/?) response lines were derived for fractionated irradiation. The standard RBE calculation, using the traditional single fraction reference radiation, gave RBE values that ranged from 2.4 for a surviving fraction of 0.82–6.0 for a surviving fraction of 0.02, while the dose-independent RBE2(4.6) value was 4.5 for all surviving fraction values. Furthermore, bioeffect modeling with RBE2(?/?) and EQD2(?/?) demonstrated the capacity to predict the surviving fraction of cells irradiated with acute and fractionated low-LET radiation, ? particles and chronic exponentially decreasing dose rates of low-LET radiation. RBE2(?/?) is independent of absorbed dose for ?-particle emitters and it provides a more logical framework for data reporting and conversion to equieffective dose than the conventional dose-dependent definition of RBE. Moreover, it provides a much needed foundation for the ongoing development of an ?-particle dosimetry paradigm and will facilitate the use of tolerance dose data available from external beam radiation therapy, thereby helping to develop ?RPT as a single modality as well as for combination therapies. PMID:24502376

  19. Effect of composition and radiation on the Hertzian indentation behavior of nuclear waste glasses. [77-MeV alpha particles

    SciTech Connect

    Matzke, H.; Kahl, L.; Routbort, J.L.; Saidl, J.

    1983-01-01

    The Hertzian indentation technique has been used to determine the fracture toughness, K/sub Ic/ of two borosilicate glasses developed to contain high-level nuclear waste. For the product VG 98/12, adding selected groups of fission products leaves K/sub Ic/ unchanged, but addition of Pb lowers K/sub Ic/ by approx. 20%. Radiation with 77 MeV ..cap alpha..-particles to a dose of approx. 10/sup 15/ ..cap alpha../cm/sup 2/ increases K/sub Ic/ by approx. 75%. For the product SM 58 LW 11, the fracture toughness was measured on pieces taken from different parts of a large cylinder to investigate the effects of segregation phenomena and of partial crystallization and formation of small cristobalite inclusions which decrease K/sub Ic/ by approx. 25%.

  20. Fabrication, testing and simulation of a high spatial resolution alpha-particle imager based on ZnO nanowires in a polycarbonate nanoporous membrane

    NASA Astrophysics Data System (ADS)

    Taheri, Ali; Saramad, Shahyar; Ghalenoi, Samira; Setayeshi, Saeed

    2013-12-01

    A new architecture consisting of ZnO nanowires embedded in a polycarbonate nanoporous membrane was proposed, fabricated and simulated as a high spatial resolution alpha particle imager. The experimental and Geant4 simulation results showed that ZnO nanowires could act as scintillating fibers to prevent spread of the generated optical photons inside the imager. This property can be used to precisely determine alpha collision coordinates. An array of these nanowires can be also applied as a new high spatial resolution alpha particle imager.

  1. Determination of 239Pu and 240Pu isotope ratio for a nuclear bomb particle using X-ray spectrometry in conjunction with gamma-ray spectrometry and non-destructive alpha-particle spectrometry

    Microsoft Academic Search

    R. Pöllänen; K. Ruotsalainen; H. Toivonen

    2009-01-01

    A nuclear bomb particle from Thule containing Pu and U was analyzed using X-ray spectrometry in combination with gamma-ray spectrometry and non-destructive alpha-spectrometry. The main objective was to investigate the possibility to determine the 239Pu and 240Pu isotope ratios. Previously, X-ray spectrometry together with the above-mentioned methods has been successfully applied for radiochemically processed samples, but not for individual particles.

  2. Deceleration of Alpha Particles in the Solar Wind by Instabilities and the Rotational Force: Implications for Heating, Azimuthal Flow, and the Parker Spiral Magnetic Field

    NASA Astrophysics Data System (ADS)

    Verscharen, Daniel; Chandran, Benjamin D. G.; Bourouaine, Sofiane; Hollweg, Joseph V.

    2015-06-01

    Protons and alpha particles in the fast solar wind are only weakly collisional and exhibit a number of non-equilibrium features, including relative drifts between particle species. Two non-collisional mechanisms have been proposed for limiting differential flow between alpha particles and protons: plasma instabilities and the rotational force. Both mechanisms decelerate the alpha particles. In this paper, we derive an analytic expression for the rate {Q}{flow} at which energy is released by alpha-particle deceleration, accounting for azimuthal flow and conservation of total momentum. We show that instabilities control the deceleration of alpha particles at r\\lt {r}{crit}, and the rotational force controls the deceleration of alpha particles at r\\gt {r}{crit}, where {r}{crit}? 2.5 {AU} in the fast solar wind in the ecliptic plane. We find that {Q}{flow} is positive at r\\lt {r}{crit} and {Q}{flow}=0 at r?slant {r}{crit}, consistent with the previous finding that the rotational force does not lead to a release of energy. We compare the value of {Q}{flow} at r\\lt {r}{crit} with empirical heating rates for protons and alpha particles, denoted {Q}p and {Q}? , deduced from in situ measurements of fast-wind streams from the Helios and Ulysses spacecraft. We find that {Q}{flow} exceeds {Q}? at r\\lt 1 {AU}, and that {Q}{flow}/{Q}p decreases with increasing distance from the Sun from a value of about one at r = 0.29–0.42 AU to about 1/4 at 1 AU. We conclude that the continuous energy input from alpha-particle deceleration at r\\lt {r}{crit} makes an important contribution to the heating of the fast solar wind. We also discuss the implications of the alpha-particle drift for the azimuthal flow velocities of the ions and for the Parker spiral magnetic field.

  3. Radioactive Positron Emitter Production by Energetic Alpha Particles in Solar Flares

    NASA Astrophysics Data System (ADS)

    Murphy, R. J.; Kozlovsky, B.; Share, G. H.

    2014-12-01

    Measurements of the 0.511 MeV positron-annihilation line from solar flares are used to explore the flare process in general and ion acceleration in particular. In flares, positrons are produced primarily by the decay of radioactive positron-emitting isotopes resulting from nuclear interactions of flare-accelerated ions with ambient solar material. Kozlovsky et al. provided ion-energy-dependent production cross sections for 67 positron emitters evaluated from their threshold energies (some <1 MeV nucleon-1) to a GeV nucleon-1, incorporating them into a computer code for calculating positron-emitter production. Adequate cross-section measurements were available for proton reactions, but not for ?-particle reactions where only crude estimates were possible. Here we re-evaluate the ?-particle cross sections using new measurements and nuclear reaction codes. In typical large gamma-ray line flares, proton reactions dominate positron production, but ?-particle reactions will dominate for steeper accelerated-ion spectra because of their relatively low threshold energies. With the accelerated-3He reactions added previously, the code is now reliable for calculating positron production from any distribution of accelerated-ion energies, not just those of typical flares. We have made the code available in the online version of the Journal. We investigate which reactions, projectiles, and ion energies contribute to positron production. We calculate ratios of the annihilation-line fluence to fluences of other gamma-ray lines. Such ratios can be used in interpreting flare data and in determining which nuclear radiation is most sensitive for revealing acceleration of low-energy ions at the Sun.

  4. RADIOACTIVE POSITRON EMITTER PRODUCTION BY ENERGETIC ALPHA PARTICLES IN SOLAR FLARES

    SciTech Connect

    Murphy, R. J. [Code 7650, Naval Research Laboratory, Washington, DC 20375 (United States); Kozlovsky, B. [Tel Aviv University, Tel Aviv (Israel); Share, G. H., E-mail: murphy@ssd5.nrl.navy.mil, E-mail: benz@wise.tau.ac.il, E-mail: share@astro.umd.edu [University of Maryland, College Park, MD 20742 (United States)

    2015-01-01

    Measurements of the 0.511 MeV positron-annihilation line from solar flares are used to explore the flare process in general and ion acceleration in particular. In flares, positrons are produced primarily by the decay of radioactive positron-emitting isotopes resulting from nuclear interactions of flare-accelerated ions with ambient solar material. Kozlovsky et al. provided ion-energy-dependent production cross sections for 67 positron emitters evaluated from their threshold energies (some <1 MeV nucleon{sup –1}) to a GeV nucleon{sup –1}, incorporating them into a computer code for calculating positron-emitter production. Adequate cross-section measurements were available for proton reactions, but not for ?-particle reactions where only crude estimates were possible. Here we re-evaluate the ?-particle cross sections using new measurements and nuclear reaction codes. In typical large gamma-ray line flares, proton reactions dominate positron production, but ?-particle reactions will dominate for steeper accelerated-ion spectra because of their relatively low threshold energies. With the accelerated-{sup 3}He reactions added previously, the code is now reliable for calculating positron production from any distribution of accelerated-ion energies, not just those of typical flares. We have made the code available in the online version of the Journal. We investigate which reactions, projectiles, and ion energies contribute to positron production. We calculate ratios of the annihilation-line fluence to fluences of other gamma-ray lines. Such ratios can be used in interpreting flare data and in determining which nuclear radiation is most sensitive for revealing acceleration of low-energy ions at the Sun.

  5. Gene amplification and microsatellite instability induced in tumorigenic human bronchial epithelial cells by alpha particles and heavy ions

    NASA Technical Reports Server (NTRS)

    Piao, C. Q.; Hei, T. K.; Hall, E. J. (Principal Investigator)

    2001-01-01

    Gene amplification and microsatellite alteration are useful markers of genomic instability in tumor and transformed cell lines. It has been suggested that genomic instability contributes to the progression of tumorigenesis by accumulating genetic changes. In this study, amplification of the carbamyl-P-synthetase, aspartate transcarbamylase, dihydro-orotase (CAD) gene in transformed and tumorigenic human bronchial epithelial (BEP2D) cells induced by either alpha particles or (56)Fe ions was assessed by measuring resistance to N-(phosphonacetyl)-l-aspartate (PALA). In addition, alterations of microsatellite loci located on chromosomes 3p and 18q were analyzed in a series of primary and secondary tumor cell lines generated in nude mice. The frequency of PALA-resistant colonies was 1-3 x 10(-3) in tumor cell lines, 5-8 x 10(-5) in transformed cells prior to inoculation into nude mice, and less than 10(-7) in control BEP2D cells. Microsatellite alterations were detected in all 11 tumor cell lines examined at the following loci: D18S34, D18S363, D18S877, D3S1038 and D3S1607. No significant difference in either PALA resistance or microsatellite instability was found in tumor cell lines that were induced by alpha particles compared to those induced by (56)Fe ions.

  6. High resolution alpha particle detection using 4H-SiC epitaxial layers: Fabrication, characterization, and noise analysis

    NASA Astrophysics Data System (ADS)

    Chaudhuri, Sandeep K.; Zavalla, Kelvin J.; Mandal, Krishna C.

    2013-11-01

    In this article we report the fabrication and characterization of large area, room-temperature operable and very high resolution Schottky barrier detectors for alpha particles using 20 ?m thick n-type 4H-SiC epitaxial layers. Schottky barriers were fabricated by depositing circular nickel contacts of ~11 mm2 area on the 4H-SiC epitaxial layers. Room temperature current-voltage measurements revealed very high Schottky barrier height of 1.6 eV and extremely low leakage current of 3.5 pA at an operating reverse bias of -90 V. We also report an energy resolution of 0.29%, which is the best resolution obtained so far for uncollimated 5.48 MeV alpha particles in 4H-SiC epitaxial detectors with such a large area. Very low micropipe density (<1 cm-2) and low effective doping concentration (2.4×1014 cm-3) in the epilayer helped to achieve a high resolution even with the large detector area and a broad source. A diffusion length of ~18.6 ?m for holes has been determined in these detectors following a calculation based on a drift-diffusion model. A noise analysis in terms of equivalent noise charge revealed that the white series noise due to the detector capacitance has substantial effect on their spectroscopic performance.

  7. Evaluation of Melt-Grown, ZnO Single Crystals for Use as Alpha-Particle Detectors

    SciTech Connect

    Neal, John S [ORNL; Giles, N. C. [West Virginia University; Yang, Xiaocheng [West Virginia University; Wall, R. Andrew [Wake Forest University, Winston-Salem, NC; Ucer, Burak [Wake Forest University, Winston-Salem, NC; Williams, Richard T. [Wake Forest University, Winston-Salem, NC; Wisniewski, Dariusz J [ORNL; Boatner, Lynn A [ORNL; Rengarajan, Varatharajan [ORNL; Nause, Jeff E [ORNL; Nemeth, Bell [Cermet, Inc., Atlanta

    2008-01-01

    As part of an ongoing investigation of the scintillation properties of zinc-oxide-based scintillators, several melt-grown, ZnO single crystals have been characterized using -particle excitation, infrared reflectance, and room temperature photoluminescence. The crystals, grown by Cermet, Inc. using a pressurized melt growth process, were doped with Group 1 elements (Li), Group 2 elements (Mg), Group 3 elements (Ga, In) and Lanthanides (Gd, Er, Tm). The goals of these studies are to better understand the scintillation mechanisms associated with various members of the ZnO scintillator family and to then use this knowledge to improve the radiation detection capabilities of ZnO-based scintillators. One application for which ZnO is particularly well suited as a scintillator is as the associated particle detector in a deuterium-tritium (D-T) neutron generator. Application requirements include the exclusion of organic materials, outstanding timing resolution, and high radiation resistance. ZnO(Ga) and ZnO(In) have demonstrated fast (sub-nanosecond) decay times with relatively low light yields, and ZnO(Ga) has been used in a powder form as the associated particle detector for a D-T neutron generator. Four promising candidate materials, ZnO, ZnO:Ga, ZnO:In,Li, and ZnO:Er,Li, were identified in this study. These four samples demonstrated sub-nanosecond decay times and alpha particle excited luminescence comparable to BC-400 fast plastic scintillator. The ZnO:Mg,Ga, ZnO:Gd, and ZnO:Li samples demonstrated appreciable slow (microsecond) decay components that would be incompatible with high-counting-rate applications.

  8. Improve the catalytic activity of {alpha}-Fe{sub 2}O{sub 3} particles in decomposition of ammonium perchlorate by coating amorphous carbon on their surface

    SciTech Connect

    Zhang Yifu [Engineering Research Center of Organosilicon Compound and Material, Ministry of Education of China, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072 (China); Liu Xinghai, E-mail: liuxh@whu.edu.c [School of Printing and Packaging, Wuhan University, Wuhan 430079 (China); Nie Jiaorong [Jianghe Chemical Factory of CSSG, Yuan'an 444200 (China); Yu Lei; Zhong Yalan [Engineering Research Center of Organosilicon Compound and Material, Ministry of Education of China, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072 (China); Huang Chi, E-mail: chihuang@whu.edu.c [Engineering Research Center of Organosilicon Compound and Material, Ministry of Education of China, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072 (China)

    2011-02-15

    Sphere- and pod-like {alpha}-Fe{sub 2}O{sub 3} particles have been selectively synthesized using NH{sub 3}.H{sub 2}O and NaOH solution to adjust the pH value of the designed synthetic system, respectively. The sphere-like {alpha}-Fe{sub 2}O{sub 3} particles with diameter about 25 nm on average were encapsulated into carbon shells to fabricate a novel core-shell composite ({alpha}-Fe{sub 2}O{sub 3}-C) through the coating experiments. The catalytic performance of the products on the thermal decomposition of ammonium perchlorate (AP) was investigated by thermal gravimetric analyzer (TG) and differential thermal analysis (DTA). The thermal decomposition temperatures of AP in the presence of pod-like {alpha}-Fe{sub 2}O{sub 3}, sphere-like {alpha}-Fe{sub 2}O{sub 3} and {alpha}-Fe{sub 2}O{sub 3}-C are reduced by 72, 81 and 109 {sup o}C, respectively, which show that {alpha}-Fe{sub 2}O{sub 3}-C core-shell composites have higher catalytic activity than that of {alpha}-Fe{sub 2}O{sub 3}. -- Graphical abstract: The catalytic performance of pod-like {alpha}-Fe{sub 2}O{sub 3}, sphere-like {alpha}-Fe{sub 2}O{sub 3} and {alpha}-Fe{sub 2}O{sub 3}-C on the thermal decomposition of ammonium perchlorate (AP). Display Omitted Research highlights: {yields} Sphere- and pod-like {alpha}-Fe{sub 2}O{sub 3} particles have been selectively synthesized using NH{sub 3}.H{sub 2}O and NaOH solution to adjust the pH value. {yields} A novel core-shell composite ({alpha}-Fe{sub 2}O{sub 3}-C core-shell structured composite) has been successfully synthesized using sphere-like {alpha}-Fe{sub 2}O{sub 3} particles as the cores and glucose as the source of carbon. {yields} The thermal decomposition temperatures of AP in the presence of pod-like {alpha}-Fe{sub 2}O{sub 3}, sphere-like {alpha}-Fe{sub 2}O{sub 3} and {alpha}-Fe{sub 2}O{sub 3}-C are reduced by 72, 81 and 109 {sup o}C, respectively, which shows that these materials have high catalytic activity.

  9. Applications of 211At and 223Ra in Targeted Alpha-Particle Radiotherapy

    PubMed Central

    Vaidyanathan, Ganesan; Zalutsky, Michael R.

    2012-01-01

    Targeted radiotherapy using agents tagged with ?-emitting radionuclides is gaining traction with several clinical trials already undertaken or ongoing, and others in the advanced planning stage. The most commonly used ?-emitting radionuclides are 213Bi, 211At, 223Ra and 225Ac. While each one of these has pros and cons, it can be argued that 211At probably is the most versatile based on its half life, decay scheme and chemistry. On the other hand, for targeting bone metastases, 223Ra is the ideal radionuclide because simple cationic radium can be used for this purpose. In this review, we will discuss the recent developments taken place in the application of 211At-labeled radiopharmaceuticals and give an overview of the current status of 223Ra for targeted ?-particle radiotherapy. PMID:22202151

  10. Readout cross-talk for alpha-particle measurements in a pixelated sensor system

    NASA Astrophysics Data System (ADS)

    Norlin, B.; Reza, S.; Krapohl, D.; Fröjdh, E.; Thungström, G.

    2015-05-01

    Simulations in Medici are performed to quantify crosstalk and charge sharing in a hybrid pixelated silicon detector. Crosstalk and charge sharing degrades the spatial and spectral resolution of single photon processing X-ray imaging systems. For typical medical X-ray imaging applications, the process is dominated by charge sharing between the pixels in the sensor. For heavier particles each impact generates a large amount of charge and the simulation seems to over predict the charge collection efficiency. This indicates that some type of non modelled degradation of the charge transport efficiency exists, like the plasma effect where the plasma might shield the generated charges from the electric field and hence distorts the charge transport process. Based on the simulations it can be reasoned that saturation of the amplifiers in the Timepix system might generate crosstalk that increases the charge spread measured from ion impact on the sensor.

  11. Applications of 211At and 223Ra in targeted alpha-particle radiotherapy.

    PubMed

    Vaidyanathan, Ganesan; Zalutsky, Michael R

    2011-10-01

    Targeted radiotherapy using agents tagged with ?-emitting radionuclides is gaining traction with several clinical trials already undertaken or ongoing, and others in the advanced planning stage. The most commonly used ?-emitting radionuclides are 213Bi, 211At, 223Ra and 225Ac. While each one of these has pros and cons, it can be argued that 211At probably is the most versatile based on its half life, decay scheme and chemistry. On the other hand, for targeting bone metastases, 223Ra is the ideal radionuclide because simple cationic radium can be used for this purpose. In this review, we will discuss the recent developments taken place in the application of 211At-labeled radiopharmaceuticals and give an overview of the current status of 223Ra for targeted ?-particle radiotherapy. PMID:22202151

  12. Alpha-Particle Emitting 213Bi-Anti-EGFR Immunoconjugates Eradicate Tumor Cells Independent of Oxygenation

    PubMed Central

    Gaertner, Florian C.; Bruchertseifer, Frank; Morgenstern, Alfred; Essler, Markus; Senekowitsch-Schmidtke, Reingard

    2013-01-01

    Hypoxia is a central problem in tumor treatment because hypoxic cells are less sensitive to chemo- and radiotherapy than normoxic cells. Radioresistance of hypoxic tumor cells is due to reduced sensitivity towards low Linear Energy Transfer (LET) radiation. High LET ?-emitters are thought to eradicate tumor cells independent of cellular oxygenation. Therefore, the aim of this study was to demonstrate that cell-bound ?-particle emitting 213Bi immunoconjugates kill hypoxic and normoxic CAL33 tumor cells with identical efficiency. For that purpose CAL33 cells were incubated with 213Bi-anti-EGFR-MAb or irradiated with photons with a nominal energy of 6 MeV both under hypoxic and normoxic conditions. Oxygenation of cells was checked via the hypoxia-associated marker HIF-1?. Survival of cells was analysed using the clonogenic assay. Cell viability was monitored with the WST colorimetric assay. Results were evaluated statistically using a t-test and a Generalized Linear Mixed Model (GLMM). Survival and viability of CAL33 cells decreased both after incubation with increasing 213Bi-anti-EGFR-MAb activity concentrations (9.25 kBq/ml–1.48 MBq/ml) and irradiation with increasing doses of photons (0.5–12 Gy). Following photon irradiation survival and viability of normoxic cells were significantly lower than those of hypoxic cells at all doses analysed. In contrast, cell death induced by 213Bi-anti-EGFR-MAb turned out to be independent of cellular oxygenation. These results demonstrate that ?-particle emitting 213Bi-immunoconjugates eradicate hypoxic tumor cells as effective as normoxic cells. Therefore, 213Bi-radioimmunotherapy seems to be an appropriate strategy for treatment of hypoxic tumors. PMID:23724085

  13. NOTES ON MEASUREMENTS OF $alpha$PARTICLE ACTIVITY OF SOILS, FERTILIZERS, PLANTS AND ANIMALS

    Microsoft Academic Search

    1960-01-01

    A method is described for determining total alpha activity of a sample ; and at the same time determining the relative contributions of the uranium--; radium and thorium families. Results are reported from applications of the ; method in measurements of natural alpha radioactivity of samples of soils, ; fertilizers, plants, and animal materials. (C.H.);

  14. Particle acceleration

    NASA Technical Reports Server (NTRS)

    Vlahos, L.; Machado, M. E.; Ramaty, R.; Murphy, R. J.; Alissandrakis, C.; Bai, T.; Batchelor, D.; Benz, A. O.; Chupp, E.; Ellison, D.

    1986-01-01

    Data is compiled from Solar Maximum Mission and Hinothori satellites, particle detectors in several satellites, ground based instruments, and balloon flights in order to answer fundamental questions relating to: (1) the requirements for the coronal magnetic field structure in the vicinity of the energization source; (2) the height (above the photosphere) of the energization source; (3) the time of energization; (4) transistion between coronal heating and flares; (5) evidence for purely thermal, purely nonthermal and hybrid type flares; (6) the time characteristics of the energization source; (7) whether every flare accelerates protons; (8) the location of the interaction site of the ions and relativistic electrons; (9) the energy spectra for ions and relativistic electrons; (10) the relationship between particles at the Sun and interplanetary space; (11) evidence for more than one acceleration mechanism; (12) whether there is single mechanism that will accelerate particles to all energies and also heat the plasma; and (13) how fast the existing mechanisms accelerate electrons up to several MeV and ions to 1 GeV.

  15. Coincidence measurements between alpha particles and gamma rays in reactions induced by 85 and 155 MeV ¹²C on ¹??Sm

    E-print Network

    Cala, Steven Edward

    1978-01-01

    COINCIDENCE MEASUREMENTS BETWEEN ALPHA PARTICLES AND GAMMA RAYS 12 154 IN REACTIONS INDUCED BY 85 AND 155 MEV C ON Sm A Thesis by STEVEN EDWARD CALA Submitted to the Graduate College of Texas A&M University in partial fulfillment... of the requirement for the degree of MASTER OF SCIENCE August 1978 Major Subject: Chemistry COINCIDENCE MEASUREMENTS BETWEEN ALPHA PARTICLES AND GAMMA RAYS 12 154 IN REACTIONS INDUCED BY 85 AND 155 MEV C ON Sm A Thesis by STEVEN EDWARD CALA Approved...

  16. Complex aberrations in lymphocytes exposed to mixed beams of (241)Am alpha particles and X-rays.

    PubMed

    Staaf, Elina; Deperas-Kaminska, Marta; Brehwens, Karl; Haghdoost, Siamak; Czub, Joanna; Wojcik, Andrzej

    2013-08-30

    Modern radiotherapy treatment modalities are associated with undesired out-of-field exposure to complex mixed beams of high and low energy transfer (LET) radiation that can give rise to secondary cancers. The biological effectiveness of mixed beams is not known. The aim of the investigation was the analysis of chromosomal damage in human peripheral blood lymphocytes (PBL) exposed to a mixed beam of X-rays and alpha particles. Using a dedicated exposure facility PBL were exposed to increasing doses of alpha particles (from (241)Am), X-rays and a mixture of both. Chromosomal aberrations were analysed in chromosomes 2, 8 and 14 using fluorescence in situ hybridisation. The found and expected frequencies of simple and complex aberrations were compared. Simple aberrations showed linear dose-response relationships with doses. A higher than expected frequency of simple aberrations was only observed after the highest mixed beam dose. A linear-quadratic dose response curve for complex aberrations was observed after mixed-beam exposure. Higher than expected frequencies of complex aberrations were observed for the two highest doses. Both the linear-quadratic dose-response relationship and the calculation of expected frequencies show that exposure of PBL to mixed beams of high and low LET radiation leads to a higher than expected frequency of complex-type aberrations. Because chromosomal changes are associated with cancer induction this result may imply that the cancer risk of exposure to mixed beams in radiation oncology may be higher than expected based on the additive action of the individual dose components. PMID:23669292

  17. The implications of particle energy and acidic media on gross alpha and gross beta determination using liquid scintillation.

    PubMed

    Zapata-García, D; Llauradó, M; Rauret, G

    2012-04-01

    The interaction of humans with radioactivity present in the environment from natural and artificial sources necessitates an evaluation of its risk on human health. Gross alpha and gross beta activities can provide a rapid evaluation of the radioactive content of a sample and can be simultaneously determined by using liquid scintillation counters. However, calibration of the liquid scintillation counter is required and is affected by many factors, such as particle energy and the acidity of the media. This study investigates what effect the particle energy used for calibration has on misclassification and how to account for this misclassification in routine measurements. The variability in measurement produced by the final pH, as well as any acids used in sample treatment, was also studied. These results showed that the most commonly used acid for these types of analyses, HNO(3), produced a high amount of misclassifications at very low pH. The results improved when HCl was used to adjust the sample to low pH. PMID:22200448

  18. Targeting Aberrant DNA double strand break repair in triple negative breast cancer with alpha particle emitter radiolabeled anti-EGFR antibody

    PubMed Central

    Song, Hong; Hedayati, Mohammad; Hobbs, Robert F.; Shao, Chunbo; Bruchertseifer, Frank; Morgenstern, Alfred; DeWeese, Theodore L.; Sgouros, George

    2013-01-01

    The higher potential efficacy of alpha-particle radiopharmaceutical therapy lies in the 3 to 8-fold greater biological effectiveness (RBE) of alpha particles relative to photon or beta-particle radiation. This greater RBE, however, also applies to normal tissue, thereby reducing the potential advantage of high RBE. Since alpha particles typically cause DNA double strand breaks (DSBs), targeting tumors that are defective in DSB repair effectively increases the RBE, yielding a secondary, RBE-based differentiation between tumor and normal tissue that is complementary to conventional, receptor-mediated tumor targeting. In some triple negative breast cancers (TNBC, ER?/PR?/HER-2?), germline mutation in BRCA-1, a key gene in homologous recombination (HR) DSB repair, predisposes patients to early onset of breast cancer. These patients have few treatment options once the cancer has metastasized. In this study, we investigated the efficacy of alpha particle emitter, 213Bi labeled anti-EGFR antibody, Cetuximab, in BRCA-1 defective TNBC. 213Bi-Cetuximab was found to be significantly more effective in the BRCA-1 mutated TNBC cell line HCC1937 than BRCA-1 competent TNBC cell MDA-MB-231. siRNA knockdown of BRCA-1 or DNA-PKcs, a key gene in non-homologous end joining (NHEJ) DSB repair pathway, also sensitized TNBC cells to 213Bi-Cetuximab. Furthermore, the small molecule inhibitor of DNA-PKcs, NU7441, sensitized BRCA-1 competent TNBC cells to alpha particle radiation. Immunofluorescent staining of ?H2AX foci and comet assay confirmed that enhanced RBE is caused by impaired DSB repair. These data offer a novel strategy for enhancing conventional receptor-mediated targeting with an additional, potentially synergistic radiobiological targeting that could be applied to TNBC. PMID:23873849

  19. Targeting aberrant DNA double-strand break repair in triple-negative breast cancer with alpha-particle emitter radiolabeled anti-EGFR antibody.

    PubMed

    Song, Hong; Hedayati, Mohammad; Hobbs, Robert F; Shao, Chunbo; Bruchertseifer, Frank; Morgenstern, Alfred; Deweese, Theodore L; Sgouros, George

    2013-10-01

    The higher potential efficacy of alpha-particle radiopharmaceutical therapy lies in the 3- to 8-fold greater relative biological effectiveness (RBE) of alpha particles relative to photon or beta-particle radiation. This greater RBE, however, also applies to normal tissue, thereby reducing the potential advantage of high RBE. As alpha particles typically cause DNA double-strand breaks (DSB), targeting tumors that are defective in DSB repair effectively increases the RBE, yielding a secondary, RBE-based differentiation between tumor and normal tissue that is complementary to conventional, receptor-mediated tumor targeting. In some triple-negative breast cancers (TNBC; ER(-)/PR(-)/HER-2(-)), germline mutation in BRCA-1, a key gene in homologous recombination DSB repair, predisposes patients to early onset of breast cancer. These patients have few treatment options once the cancer has metastasized. In this study, we investigated the efficacy of alpha-particle emitter, (213)Bi-labeled anti-EGF receptor antibody, cetuximab, in BRCA-1-defective TNBC. (213)Bi-cetuximab was found to be significantly more effective in the BRCA-1-mutated TNBC cell line HCC1937 than BRCA-1-competent TNBC cell MDA-MB-231. siRNA knockdown of BRCA-1 or DNA-dependent protein kinase, catalytic subunit (DNA-PKcs), a key gene in non-homologous end-joining DSB repair pathway, also sensitized TNBC cells to (213)Bi-cetuximab. Furthermore, the small-molecule inhibitor of DNA-PKcs, NU7441, sensitized BRCA-1-competent TNBC cells to alpha-particle radiation. Immunofluorescent staining of ?-H2AX foci and comet assay confirmed that enhanced RBE is caused by impaired DSB repair. These data offer a novel strategy for enhancing conventional receptor-mediated targeting with an additional, potentially synergistic radiobiological targeting that could be applied to TNBC. PMID:23873849

  20. PPPL3164 Preprint Date: January 1996, UC420 Alpha Particle Losses from Tokamak Fusion Test Reactor

    E-print Network

    Reactor Deuterium­Tritium Plasmas D. S. Darrow, S. J. Zweben, S. Batha*, R. V. Budny, C. E. Bush + , Z. A. Spong + , E. J. Strait # , G. Taylor, R. B. White, J. R. Wilson, K.­L. Wong, and M. C. Zarnstorff can have a significant influence on tokamak reactor viability, the loss of deuterium­tritium alpha

  1. Nickel-59 in Surface Layers of Lunar Basalt 74275: Implications for the Solar Alpha Particle Flux

    NASA Technical Reports Server (NTRS)

    Schnabel, C.; Xue, S.; Ma, P.; Herzog, G. F.; Fifield, K.; Cresswell, R. G.; diTada, M. L.; Hausladen, Paul; Reedy, R. C.

    2000-01-01

    By using AMS we have profiled 59 Ni/Ni ratios in lunar basalt 74275. Activities (dpm 59 Ni/[kg Fe]) range from 120 to 10 at depths (mg/cm 2) from about 30 to 650. Modeling results hint at higher solar alpha fluxes during the last about 0.5 My than during the last approximately 1 My.

  2. TF Ripple Loss of Alpha Particles from the ITER Interim Design: Simulation and Theory

    E-print Network

    the normalization of a simple model for stochastic ripple losses within the TRANSP code [6]. Collisions were found without collisional eects. Good agree- ment was found in comparing appropriately normalized TRANSP in the ITER database. TRANSP simulations of ITER also provided alpha source pro#12;les, before and after

  3. TF Ripple Loss of Alpha Particles from the ITER Interim Design: Simulation and Theory

    E-print Network

    the normalization of a simple model for stochastic ripple losses within the TRANSP code [6]. Collisions were found without collisional effects. Good agree­ ment was found in comparing appropriately normalized TRANSP database. TRANSP simulations of ITER also provided alpha source profiles, before and after sawtooth

  4. Screening materials with the XIA UltraLo alpha particle counter at Southern Methodist University

    SciTech Connect

    Nakib, M. Z.; Cooley, J.; Kara, B.; Qiu, H.; Scorza, S. [Department of Physics, Southern Methodist University, Dallas, TX (United States)] [Department of Physics, Southern Methodist University, Dallas, TX (United States); Guiseppe, V. E. [Department of Physics, University of South Dakota, Vermillion, SD (United States)] [Department of Physics, University of South Dakota, Vermillion, SD (United States); Rielage, K. [Los Alamos National Laboratory, Los Alamos, NM (United States)] [Los Alamos National Laboratory, Los Alamos, NM (United States); Schnee, R. W. [Department of Physics, Syracuse University, Syracuse, NY (United States)] [Department of Physics, Syracuse University, Syracuse, NY (United States)

    2013-08-08

    Southern Methodist University houses one of five existing commercially available UltraLo 1800 production model alpha counters made by XIA LLC. The instrument has an electron drift chamber with a 707 cm{sup 2} or 1800 cm{sup 2} counting region which is determined by selecting the inner electrode size. The SMU team operating this device is part of the SuperCDMS screening working group, and uses the alpha counter to study the background rates from the decay of radon in materials used to construct the SuperCDMS experiment. We have studied four acrylic samples obtained from the MiniCLEAN direct dark matter search with the XIA instrument demonstrating its utility in low background experiments by investigating the plate-out of {sup 210}Pb and comparing the effectiveness of cleaning procedures in removing {sup 222}Rn progenies from the samples.

  5. A Method of Measuring Hydrogen Isotopes in Surface Layers of Planetary Soils by Spectroscopy of Recoil Protons in Alpha Particle Elastic Scattering

    Microsoft Academic Search

    B. N. Korchuganov; G. G. Dol'nikov; M. V. Gerasimov; O. F. Prilutskii; R. Rider; G. Waenke; T. Economou

    2004-01-01

    A theoretical and experimental feasibility study of possible determination of the hydrogen and deuterium concentrations in the surface layers of planetary bodies is presented. The method under study is the recoil proton and deuteron spectrometry of forward scattering in the course of elastic interaction of alpha particles with the nuclei of hydrogen isotopes. The spectra of recoil protons and deuterons

  6. Observation of alpha particle loss from JET plasmas during ion cyclotron resonance frequency heating using a thin foil Faraday cup detector array

    Microsoft Academic Search

    D. S. Darrow; F. E. Cecil; V. Kiptily; K. Fullard; A. Horton; A. Murari; Jet Efda Contributors

    2010-01-01

    The loss of MeV alpha particles from JET plasmas has been measured with a set of thin foil Faraday cup detectors during third harmonic heating of helium neutral beam ions. Tail temperatures of ~2 MeV have been observed, with radial scrape off lengths of a few centimeters. Operational experience from this system indicates that such detectors are potentially feasible for

  7. Substate Populations and Nuclear Polarization Produced by Inelastic Alpha-Particle Scattering on Carbon12

    Microsoft Academic Search

    T. D. Hayward; F. H. Schmidt

    1970-01-01

    We have measured the normalized alpha-gamma angular correlation in the reaction plane for excitation of the 4.44-MeV, 2+ state of 12C at 22.750 MeV. These data yield the relative populations (am)2 of the three magnetic substates referred to the normal to the reaction plane. The ambiguity between (a+2)2 and (a-2)2 was resolved by coincidence measurements of the circular polarization of

  8. Effects of pre-equilibrium nucleon emission on excitation functions of various reactions in vanadium induced by alpha particles

    Microsoft Academic Search

    N L Singh; S Mukherjee; A V Mohan Rao; L Chaturvedi; P P Singh

    1995-01-01

    Excitation functions for the 51V(( alpha ,n), ( alpha ,3n), ( alpha ,p3n), ( alpha ,p6n), ( alpha , alpha 3n), ( alpha , alpha 2pn), ( alpha ,2 alpha ), ( alpha ,2 alpha n) and ( alpha ,2 alpha 3n)) reactions have been measured up to 120 MeV using the stacked foil technique with a view to improving

  9. Cross-sections for Balmer-alpha excitation in heavy-particle collisions

    SciTech Connect

    Bae, Y.K.

    1982-08-01

    Doppler shifted and unshifted Balmer-alpha radiation has been observed in the absolute sense for energetic H/sup +/, H/sub 2//sup +/ and H/sub 3//sup +/ ions incident on molecular hydrogen by the method of decay inside the target within the energy range of 20 keV to 150 keV. Most of the measurements were based on single-collision conditions, but a simple thick-target experiment has been tried for the case of dissociative excitation of the target molecules by H atoms.

  10. Microfabricated particle focusing device

    DOEpatents

    Ravula, Surendra K.; Arrington, Christian L.; Sigman, Jennifer K.; Branch, Darren W.; Brener, Igal; Clem, Paul G.; James, Conrad D.; Hill, Martyn; Boltryk, Rosemary June

    2013-04-23

    A microfabricated particle focusing device comprises an acoustic portion to preconcentrate particles over large spatial dimensions into particle streams and a dielectrophoretic portion for finer particle focusing into single-file columns. The device can be used for high throughput assays for which it is necessary to isolate and investigate small bundles of particles and single particles.

  11. Optical appearance of alpha particle tracks in CR-39 SSNTD K.N. Yu *, H.H.W. Lee, A.W.T. Wong, Y.L. Law, S.F.L. Cheung, D. Nikezic, F.M.F. Ng

    E-print Network

    Yu, K.N.

    .40; 23.60 Keywords: CR-39 detector; Alpha particles; Tracks; Ray tracing; Gray level 1. Introduction OneOptical appearance of alpha particle tracks in CR-39 SSNTD K.N. Yu *, H.H.W. Lee, A.W.T. Wong, Y of the challenging tasks in the application of solid- state nuclear track detectors (SSNTDs) is the automation

  12. Quark matter or new particles?

    NASA Technical Reports Server (NTRS)

    Michel, F. Curtis

    1988-01-01

    It has been argued that compression of nuclear matter to somewhat higher densities may lead to the formation of stable quark matter. A plausible alternative, which leads to radically new astrophysical scenarios, is that the stability of quark matter simply represents the stability of new particles compounded of quarks. A specific example is the SU(3)-symmetric version of the alpha particle, composed of spin-zero pairs of each of the baryon octet (an 'octet' particle).

  13. Further explorations of the alpha-particle optical model potential at low energies for the mass range A=45-209

    E-print Network

    V. Avrigeanu; M. Avrigeanu; C. M?n?ilescu

    2014-10-28

    The recent high-precision measurements of alpha-particle induced reaction data below the Coulomb barrier (B) make possible the understanding of limits and possible improvement of a previous optical model potential (OMP) for alpha-particles on nuclei within the mass number range 45130. Moreover, underestimation of reaction cross sections for well-deformed nuclei is removed by using ~7% larger radius for the surface imaginary part of this spherical OMP. Improved input parameters based on recent independent data, particularly gamma-ray strength functions, but no empirical rescaling factor of the gamma and/or neutron widths have been involved within statistical model calculation of the corresponding (alpha,x) reaction cross sections.

  14. Characteristics and mechanisms of the bystander response in monolayer cell cultures exposed to very low fluences of alpha particles

    NASA Astrophysics Data System (ADS)

    Little, John B.; Azzam, Edouard I.; de Toledo, Sonia M.; Nagasawa, Hatsumi

    2005-02-01

    When confluent cultures of mammalian cells are irradiated with very low fluences of alpha particles whereby only occasional cells receive any radiation exposure, genetic changes are observed in the non-irradiated ("bystander") cells. Upregulation of the p53 damage-response pathway as well as activation of proteins in the MAPK family occurred in bystander cells; p53 was phosphorylated on the serine 15 residue suggesting that the upregulation of p53 was a consequence of DNA damage. Damage signals were transmitted to bystander cells through gap junctions, as confirmed by the use of genetically manipulated cells including connexin43 knockouts. Expression of connexin43 was markedly enhanced by irradiation. A moderate bystander effect was observed for specific gene mutations and chromosomal aberrations. This effect was markedly enhanced in cells defective in the non-homologous end joining DNA repair pathway. Finally, an upregulation of oxidative metabolism occurred in bystander cells; the increased levels of reactive oxygen species appeared to be derived from flavine-containing oxidase enzymes. We hypothesize that genetic effects observed in non-irradiated bystander cells are a consequence of oxidative base damage; >90% of mutations in bystander cells were point mutations. When bystander cells cannot repair DNA double strand breaks, they become much more sensitive to the induction of chromosomal aberrations and mutations, the latter consisting primarily of deletion mutants. While we propose that the genetic effects occurring in bystander cells are a consequence of oxidative stress, the nature of the signal that initiates this process remains to be determined.

  15. Cell Cycle Checkpoint Proteins p21 and Hus1 Regulating Intercellular Signaling Induced By Alpha Particle Irradiation

    NASA Astrophysics Data System (ADS)

    Wu, Lijun; Zhao, Ye; Wang, Jun; Hang, Haiying

    In recent years, the attentions for radiation induced bystander effects (RIBE) have been paid on the intercellular signaling events connecting the irradiated and non-irradiated cells. p21 is a member of the Cip/Kip family and plays essential roles in cell cycle progression arrest after cellular irradiation. DNA damage checkpoint protein Hus1 is a member of the Rad9-Rad1-Hus1 complex and functions as scaffold at the damage sites to facilitate the activation of downstream effectors. Using the medium trasfer method and the cells of MEF, MEF (p21-/-), MEF (p21-/-Hus1-/-) as either medium donor or receptor cells, it was found that with 5cGy alpha particle irradiation, the bystander cells showed a significant induction of -H2AX for normal MEFs (p¡0.05). However, the absence of p21 resulted in deficiency in inducing bystander effects. Further results indicated p21 affected the intercellular DNA damage signaling mainly through disrupting the production or release of the damage signals from irradiated cells. When Hus1 and p21 were both knocked out, an obvious induction of -H2AX recurred in bystander cells and the induction of -H2AX was GJIC (gap junction-mediated intercellular communication) dependent, indicating the interrelationship between p21 and Hus1 regulated the production and relay of DNA damage signals from irradiated cells to non-irradiated bystander cells.

  16. Calculation of effective atomic number and electron density of essential biomolecules for electron, proton, alpha particle and multi-energetic photon interactions

    NASA Astrophysics Data System (ADS)

    Kurudirek, Murat; Onaran, Tayfur

    2015-07-01

    Effective atomic numbers (Zeff) and electron densities (Ne) of some essential biomolecules have been calculated for total electron interaction, total proton interaction and total alpha particle interaction using an interpolation method in the energy region 10 keV-1 GeV. Also, the spectrum weighted Zeff for multi-energetic photons has been calculated using Auto-Zeff program. Biomolecules consist of fatty acids, amino acids, carbohydrates and basic nucleotides of DNA and RNA. Variations of Zeff and Ne with kinetic energy of ionizing charged particles and effective photon energies of heterogeneous sources have been studied for the given materials. Significant variations in Zeff and Ne have been observed through the entire energy region for electron, proton and alpha particle interactions. Non-uniform variation has been observed for protons and alpha particles in low and intermediate energy regions, respectively. The maximum values of Zeff have found to be in higher energies for total electron interaction whereas maximum values have found to be in relatively low energies for total proton and total alpha particle interactions. When it comes to the multi-energetic photon sources, it has to be noted that the highest Zeff values were found at low energy region where photoelectric absorption is the pre-dominant interaction process. The lowest values of Zeff have been shown in biomolecules such as stearic acid, leucine, mannitol and thymine, which have highest H content in their groups. Variation in Ne seems to be more or less the same with the variation in Zeff for the given materials as expected.

  17. Production of the therapeutic radionuclides 193mPt and 195mPt with high specific activity via alpha-particle-induced reactions on 192Os.

    PubMed

    Hilgers, K; Coenen, H H; Qaim, S M

    2008-04-01

    For the production of therapy-relevant radionuclides (193m)Pt (T(1/2)=4.33 d) and (195m)Pt (T(1/2)=4.03 d) with a high specific activity, the (192)Os(alpha,n)(195m)Pt and (192)Os(alpha,3n)(193m)Pt nuclear reactions were investigated for the first time from their respective thresholds up to 28 MeV. Thin samples of enriched (192)Os were prepared by electrodeposition on Ni, and the conventional stacked-foil technique was used for cross-section measurements. The calculated thick target yields were found to be 0.013 MBq/microA h for the (192)Os(alpha,n)(195m)Pt reaction in the energy range of E(alpha)=24-->18 MeV, and 0.25 MBq/microA h for the (192)Os(alpha,3n)(193m)Pt reaction in the energy range of E(alpha)=28-->24 MeV. The two radionuclides could not be detected in the interactions of (3)He particles with (192)Os. A production method involving high-current alpha-particle irradiation of enriched (192)Os and efficient chemical separation of radioplatinum was developed. Batch yields of about 1 MBq (195m)Pt and 8.7 MBq (193m)Pt were achieved. Compared to the reactor production these batch yields are very low, but the (192)Os(alpha,n)(195m)Pt and (192)Os(alpha,3n)(193m)Pt reactions are superior with respect to the specific activity of the products which is higher by two orders of magnitude. PMID:18083038

  18. Single particle tracking of alpha7 nicotinic AChR in hippocampal neurons reveals regulated confinement at glutamatergic and GABAergic perisynaptic sites.

    PubMed

    Bürli, Thomas; Baer, Kristin; Ewers, Helge; Sidler, Corinne; Fuhrer, Christian; Fritschy, Jean-Marc

    2010-01-01

    Alpha7 neuronal nicotinic acetylcholine receptors (alpha7-nAChR) form Ca(2+)-permeable homopentameric channels modulating cortical network activity and cognitive processing. They are located pre- and postsynaptically and are highly abundant in hippocampal GABAergic interneurons. It is unclear how alpha7-nAChRs are positioned in specific membrane microdomains, particularly in cultured neurons which are devoid of cholinergic synapses. To address this issue, we monitored by single particle tracking the lateral mobility of individual alpha7-nAChRs labeled with alpha-bungarotoxin linked to quantum dots in live rat cultured hippocampal interneurons. Quantitative analysis revealed different modes of lateral diffusion of alpha7-nAChR dependent on their subcellular localization. Confined receptors were found in the immediate vicinity of glutamatergic and GABAergic postsynaptic densities, as well as in extrasynaptic clusters of alpha-bungarotoxin labeling on dendrites. alpha7-nAChRs avoided entering postsynaptic densities, but exhibited reduced mobility and long dwell times at perisynaptic locations, indicative of regulated confinement. Their diffusion coefficient was lower, on average, at glutamatergic than at GABAergic perisynaptic sites, suggesting differential, synapse-specific tethering mechanisms. Disruption of the cytoskeleton affected alpha7-nAChR mobility and cell surface expression, but not their ability to form clusters. Finally, using tetrodotoxin to silence network activity, as well as exposure to a selective alpha7-nAChR agonist or antagonist, we observed that alpha7-nAChRs cell surface dynamics is modulated by chronic changes in neuronal activity. Altogether, given their high Ca(2+)-permeability, our results suggest a possible role of alpha7-nAChR on interneurons for activating Ca(2+)-dependent signaling in the vicinity of GABAergic and glutamatergic synapses. PMID:20634896

  19. PARTICLE IMPACT DAMPING

    Microsoft Academic Search

    R. D. FRIEND; V. K. KINRA

    2000-01-01

    Particle impact damping (PID) is a means for achieving high structural damping by the use of a particle-filled enclosure attached to the structure in a region of high displacements. The particles absorb kinetic energy of the structure and convert it into heat through inelastic collisions between the particles and the enclosure, and amongst the particles. In this work, PID is

  20. Monte Carlo particle-trajectory models for neutral cometary gases. I. Models and equations. II. The spatial morphology of the Lyman-alpha coma

    SciTech Connect

    Combi, M.R.; Smyth, W.H.

    1988-04-01

    The mathematical derivations of various methods employed in the Monte Carlo particle-trajectory model (MCPTM) are presented, and the application of the MCPTM to the calculation of the photochemical heating of the inner coma through the partial thermalization of cometary hydrogen atoms produced by the photodissociation of water is discussed. This model is then used to explain the observed morphology of the spatially extended Ly-alpha comas of comets. The rocket and Skylab images of the Ly-alpha coma of Comet Kohoutek are examined. 90 references.

  1. Non-destructive alpha-particle activation analysis of P, Cl, K and Ca in marine macro-alga samples using synthetic multielement reference material as comparative standard

    Microsoft Academic Search

    Y. Iwata; H. Naitoh; N. Suzuki

    1992-01-01

    A Synthetic Reference Material (SyRM) composed with accurately known amounts of 12 elements has been prepared. The elemental composition of the SyRM is closely similar to that of marine macro-algac sample. The elemental composition of the SyRM was regulated by the starting materials used for the synthesis. The SyRM was used as a comparative standard for non-destructive alpha-particle activation analysis

  2. Observation of alpha particle loss from JET plasmas during ion cyclotron resonance frequency heating using a thin foil Faraday cup detector array.

    PubMed

    Darrow, D S; Cecil, F E; Kiptily, V; Fullard, K; Horton, A; Murari, A

    2010-10-01

    The loss of MeV alpha particles from JET plasmas has been measured with a set of thin foil Faraday cup detectors during third harmonic heating of helium neutral beam ions. Tail temperatures of ? 2?MeV have been observed, with radial scrape off lengths of a few centimeters. Operational experience from this system indicates that such detectors are potentially feasible for future large tokamaks, but careful attention to screening rf and MHD induced noise is essential. PMID:21058457

  3. Observation of alpha particle loss from JET plasmas during ion cyclotron resonance frequency heating using a thin foil Faraday cup detector array

    SciTech Connect

    Darrow, D. S. [Princeton Plasma Physics Laboratory, Princeton, New Jersey 08543 (United States); Cecil, F. E. [Physics Department, Colorado School of Mines, Golden, Colorado 80401 (United States); Kiptily, V.; Fullard, K.; Horton, A. [Culham Centre for Fusion Energy, Euratom/CCFE Fusion Assoc., Abingdon, Oxon OX14 3DB (United Kingdom); Murari, A. [Consorzio RFX-Associazione EURATOM ENEA per la Fusione, I-35127 Padova (Italy); Collaboration: JET EFDA Contributors

    2010-10-15

    The loss of MeV alpha particles from JET plasmas has been measured with a set of thin foil Faraday cup detectors during third harmonic heating of helium neutral beam ions. Tail temperatures of {approx}2 MeV have been observed, with radial scrape off lengths of a few centimeters. Operational experience from this system indicates that such detectors are potentially feasible for future large tokamaks, but careful attention to screening rf and MHD induced noise is essential.

  4. Design and calibration of a two-channel low-noise heterodyne receiver for use in a CO/sub 2/ laser Thomson scattering alpha particle diagnostic

    SciTech Connect

    Bennett, C.A.; Richards, R.K.; Hutchinson, D.P.

    1988-03-01

    A dual channel low noise heterodyne receiver has been constructed as part of a development effort to build a carbon dioxide laser based Thomson scattering alpha particle diagnostic for a burning plasma experiment. The receiver employs two wide bandwidth (>1 GHz) HgCdTe photovoltaic mixers followed by low noise IF amplifiers. A noise equivalent power of less than 3.0 )times) 10/sup -20/ WHz has been demonstrated. Design details and calibration methods are described. 8 refs

  5. Optical-Model Analysis of Alpha-Particle Scattering by 36Ar from 12.83 to 17.83 MeV

    Microsoft Academic Search

    W. J. Wallace; K. R. Knuth; R. H. Davis

    1970-01-01

    Forty-six-point angular distributions for the elastic scattering of alpha particles by 36Ar have been measured with a gas target from 12.83 to 17.83 MeV in 20-keV intervals throughout the angular range from 29.0 to 167.8° (c.m.). Optical-model fits to the data smoothed in energy with a Lorentzian weighting function have been obtained. The computed cross sections were obtained from an

  6. Stopping of 0.3 1.2 MeV/u protons and alpha particles in Si

    NASA Astrophysics Data System (ADS)

    Abdesselam, M.; Ouichaoui, S.; Azzouz, M.; Chami, A. C.; Siad, M.

    2008-09-01

    The stopping cross sections ?(E) of silicon for protons and alpha particles have been measured over the velocity range 0.3-1.2 MeV/u from a Si//SiO2//Si (SIMOX) target using the Rutherford backscattering spectrometry (RBS) with special emphasis put on experimental aspects. A detection geometry coupling simultaneously two solid-state Si detectors placed at 165° and 150° relative to each side of the incident beam direction was used to measure the energies of the scattered ions and determine their energy losses within the stopping medium. In this way, the basic energy parameter, Ex, at the Si/SiO2 interface for a given incident energy E0 is the same for ions backscattered in the two directions off both the Si and O target elements, and systematic uncertainties in the ?(E) data mainly originating from the target thickness are significantly minimized. A powerful computer code has been elaborated for extracting the relevant ?(E) experimental data and the associated overall uncertainty that amounts to less than 3%. The measured ?(E) data sets were found to be in fair agreement with Paul's compilation and with values calculated by the SRIM 06 computer code. In the case of 4He+ ions, experimental data for the ? effective charge parameter have been deduced by scaling the measured stopping cross sections to those of protons crossing the same target with the same velocity, and compared to the predictions of the SRIM 06 computer code. It is found that the ?-parameter values generated by the latter code slightly deviate from experiment over the velocity region around the stopping cross section maximum where strong charge exchanges usually occur.

  7. Particle Physics Tutor

    NSDL National Science Digital Library

    Particle Data Group of Lawrence Berkeley National Laboratory

    The particle physics group of Lawrence Berkeley National Laboratory presents and award winning interactive tour of quarks, neutrinos, antimatter, extra dimensions, dark matter, accelerators, and particle detectors.

  8. Variation in RBE for Survival of V79-4 Cells as a Function of Alpha-Particle (Helium Ion) Energy.

    PubMed

    Tracy, Bliss L; Stevens, David L; Goodhead, Dudley T; Hill, Mark A

    2015-07-01

    High linear energy transfer (LET) ? particles are important with respect to the carcinogenic risk associated with human exposure to ionizing radiation, most notably to radon and its progeny. Additionally, the potential use of alpha-particle-emitting radionuclides in radiotherapy is increasingly being explored. Within the body the emitted alpha particles slow down, traversing a number of cells with a range of energies and therefore with varying efficiencies at inducing biological response. The LET of the particle typically rises from between ~70-90 keV ?m(-1) at the start of the track (depending on initial energy) to a peak of ~237 keV ?m(-1) towards the end of the track, before falling again at the very end of its range. To investigate the variation in biological response with incident energy, a plutonium-238 alpha-particle irradiator was calibrated to enable studies with incident energies ranging from 4.0 MeV down to 1.1 MeV. The variation in clonogenic survival of V79-4 cells was determined as a function of incident energy, along with the relative variation in the initial yields of DNA double-strand breaks (DSB) measured using the FAR assay. The clonogenic survival data also extends previously published data obtained at the Medical Research Council (MRC), Harwell using the same cells irradiated with helium ions, with energies ranging from 34.9 MeV to 5.85 MeV. These studies were performed in conjunction with cell morphology measurements on live cells enabling the determination of absorbed dose and calculation of the average LET in the cell. The results show an increase in relative biological effectiveness (RBE) for cell inactivation with decreasing helium ion energy (increasing LET), reaching a maximum for incident energies of ~3.2 MeV and corresponding average LET of 131 keV ?m(-1), above which the RBE is observed to fall at lower energies (higher LETs). The effectiveness of single alpha-particle traversals (relevant to low-dose exposure) at inducing cell inactivation was observed to increase with decreasing energy to a peak of ~68% survival probability for incident energies of ~1.8 MeV (average LET of 190 keV ?m(-1)) producing ~0.39 lethal lesions per track. However, the efficiency of a single traversal will also vary significantly with cell morphology and angle of incidence, as well as cell type. PMID:26121227

  9. Low-altitude measurements of precipitating protons, alpha particles, and heavy ions during the geomagnetic storm on March 26-27, 1976

    NASA Technical Reports Server (NTRS)

    Scholer, M.; Hovestadt, D.; Hartmann, G.; Blake, J. B.; Fennell, J. F.; Gloeckler, G.

    1979-01-01

    During the geomagnetic storm of March 16-17, 1976, observations were made of precipitating protons, alpha particles, and heavy ions by two counter telescopes aboard the low-altitude S3-2 satellite. These observations are presented in this paper and their significance discussed. Briefly, a two-zone precipitation region is observed on the nightside, at L equals 2.7 and L equals 4.0 with an alpha/p ratio of about 0.008 in the low-latitude region and about 0.0009 at higher latitude at 0.4 MeV/necleon. The heavier ions, CNO nuclei, are seen in the low-latitude zone with a CNO/alpha ratio of about 0.056 at 0.25 MeV/nucleon.

  10. Elemental Analysis of the Surface of Comet 67p/Churyumov-Gerasimenko with the Alpha Particle X-Ray Spectrometer APXS on the Rosetta Lander Philae: Preliminary Results

    NASA Astrophysics Data System (ADS)

    Klingelhoefer, G.; Schmanke, D.; Girones-Lopez, J.; Brueckner, J.; d'Uston, C.; Economou, T.; Gellert, R.; Markovski, C.

    2014-12-01

    After a 10 years cruise the Rosetta probe has reached its final target, the comet 67P/Churyumov-Gerasimenko. The main objectives of the mission are to gain more knowledge of the composition, the origin and formation of comets and the solar system. After extensive remote exploration of the comet the lander Philae will be separated to land on the comet surface, starting immediately examining its landing site with its scientific payload. Part of this payload is the APXS (Alpha Particle X-Ray Spectrometer). It will measure in situ the chemical composition of the comet's surface and it's changes during the journey of the comet towards the sun. APXS is a combination of two spectrometers in one single instrument. It will irradiate the comet surface using Curium 244 sources, which are emitting alpha-particle and X-rays. In the alpha-mode the instrument uses alpha backscattering spectroscopy to detect lower Z elements like C, N and O and groups of elements with higher Z. In the X-ray mode alpha particle / X-ray induced X-ray spectroscopy (XRF) will allow the detection of most of the higher Z elements from Na up to Ni and above. Both modes will be always run in parallel allowing to determine lower and higher Z elements simultaneously. For 3 years the solar powered Rosetta probe had to pass a hibernation phase because of a long passage far away to the sun. After wakeup in January 2014 an extensive test phase of all instruments and subsystems has been performed, including the APXS. After landing on the comet an intense initial measurement phase of all instruments is planned, the First Science Sequence (FSS). It will be followed by a long term science phase (LTS). As long as possible APXS and the other instruments will continue to measure and monitor the changes and increasing activity of the comet during its journey towards the inner region of the solar system.The project is funded by the German Space Agency DLR under contracts 50 QP 0404 and 50 QP 0902. References: G. Klingelhöfer et al., The Rosetta Alpha Particle X-ray Spectrometer (APXS), Space Science Reviews, Vol.128 (2007) 383-396;

  11. Particle Tracks in Aerogel

    NASA Technical Reports Server (NTRS)

    2005-01-01

    In an experiment using a special air gun, particles are shot into aerogel at high velocities. Closeup of particles that have been captured in aerogel are shown here. The particles leave a carrot-shaped trail in the aerogel. Aerogel was used on the Stardust spacecraft to capture comet particles from Comet Wild 2.

  12. Physics of particle detection

    Microsoft Academic Search

    Claus Grupen

    2000-01-01

    In this review the basic interaction mechanisms of charged and neutral particles are presented. The ionization energy loss of charged particles is fundamental to most particle detectors and is therefore described in more detail. The production of electromagnetic radiation in various spectral ranges leads to the detection of charged particles in scintillation, Cherenkov and transition radiation counters. Photons are measured

  13. Actinides associated with particles

    Microsoft Academic Search

    Brit Salbu

    2001-01-01

    Following nuclear events such as nuclear weapons tests and nuclear accidents, particles containing actinides are released into the environment. Furthermore, actinides associated with colloids and particles are present in effluents from nuclear installations during normal operations. Thus, the presence of radioactive particles in releases from nuclear sources occurs more frequently than is usually anticipated. The composition of radionuclides in particles

  14. POPULATION BASED PARTICLE FILTERING

    Microsoft Academic Search

    Harish Bhaskar; Lyudmila Mihaylova; Simon Maskell

    This paper proposes a novel particle flltering strat- egy by combining population Monte Carlo Markov chain methods with sequential Monte Carlo chain particle which we call evolving population Monte Carlo Markov Chain (EP MCMC) flltering. Iter- ative convergence on groups of particles (popula- tions) is obtained using a specifled kernel moving particles toward more likely regions. The proposed technique introduces

  15. Radium-223 dichloride bone-targeted alpha particle therapy for hormone-refractory breast cancer metastatic to bone

    PubMed Central

    2014-01-01

    Background Hormone-refractory breast cancer metastatic to bone is a clinically challenging disease associated with high morbidity, poor prognosis, and impaired quality of life owing to pain and skeletal-related events. In a preclinical study using a mouse model of breast cancer and bone metastases, Ra-223 dichloride was incorporated into bone matrix and inhibited proliferation of breast cancer cells and differentiation of osteoblasts and osteoclasts (all P values?alpha-particle therapy for the treatment of symptomatic bone metastases in patients with castration-resistant prostate cancer. On the basis of a strong preclinical rationale, we used Ra-223 dichloride to treat bone metastases in a patient with breast cancer. Results A 44-year-old white woman with metastatic breast cancer who was estrogen receptor–positive, BRCA1-negative, BRCA2-negative, PIK3CA mutation (p.His1047Arg) positive presented with diffuse bony metastases and bone pain. She had hormone refractory and chemotherapy refractory breast cancer. After Ra-223 therapy initiation her bone pain improved, with corresponding decrease in tumor markers and mixed response in 18F-FDG PET/CT and 18F-NaF bone PET/CT. The patient derived clinical benefit from therapy. Conclusion We have shown that Ra-223 dichloride can be safely administered in a patient with hormone-refractory bone metastasis from breast cancer at the US FDA–approved dose for prostate cancer. Furthermore, because the treatment did not cause any drop in hematologic parameters, it has the potential to be combined with other radiosensitizing therapies, which may include chemotherapy or targeted therapies. Given that Ra-223 dichloride is already commercially available, this case report may help future patients and provide a rationale for initiating clinical research in the use of Ra-223 dichloride to treat bone metastasis from breast cancer. A randomized clinical trial is needed to provide evidence of efficacy, safety, and good outcomes. PMID:25243101

  16. Particle count and analysis by using a cyclone particle sampler

    Microsoft Academic Search

    N. Tokunaga; S. Okamura; S. Sasaki; S. Nakamura; F. Mieno

    1995-01-01

    We performed particle composition analysis of clean room particles by using a particle analyzer (PT1000) and a Cyclone Particle Sampler. While we expected to find only small particles in the clean room, we detected many large particles as well. Many floating particles are greatly influenced by air flow current. Particles are created by human movement and we speculate that this

  17. Determination of alpha quartz particle distribution in respirable coal-mine dust samples and reference standards. Rept. of Investigations\\/1985

    Microsoft Academic Search

    C. W. Huggins; S. N. Johnson; J. M. Segreti; J. G. Snyder

    1985-01-01

    The objective of the Bureau of Mines research was to compare the size distribution of respirable quartz collected at coal mines with that of several reference standards used to quantify quartz in coal-mine dust samples. Particle-size measurements were made on 23 samples and 4 reference standards using a scanning electron microscope in the backscatter electron mode of operation, interfaced with

  18. What is a Matter Particle?

    Microsoft Academic Search

    Tsan Ung Chan

    2006-01-01

    Positive baryon numbers (A>0) and positive lepton numbers (L>0) characterize matter particles while negative baryon numbers and negative lepton numbers characterize antimatter particles. Matter particles and antimatter particles belong to two distinct classes of particles. Matter neutral particles are particles characterized by both zero baryon number and zero lepton number. This third class of particles includes mesons formed by a

  19. Particle sensor array

    NASA Technical Reports Server (NTRS)

    Buehler, Martin G. (Inventor); Blaes, Brent R. (Inventor); Lieneweg, Udo (Inventor)

    1994-01-01

    A particle sensor array which in a preferred embodiment comprises a static random access memory having a plurality of ion-sensitive memory cells, each such cell comprising at least one pull-down field effect transistor having a sensitive drain surface area (such as by bloating) and at least one pull-up field effect transistor having a source connected to an offset voltage. The sensitive drain surface area and the offset voltage are selected for memory cell upset by incident ions such as alpha-particles. The static random access memory of the present invention provides a means for selectively biasing the memory cells into the same state in which each of the sensitive drain surface areas is reverse biased and then selectively reducing the reversed bias on these sensitive drain surface areas for increasing the upset sensitivity of the cells to ions. The resulting selectively sensitive memory cells can be used in a number of applications. By way of example, the present invention can be used for measuring the linear energy transfer of ion particles, as well as a device for assessing the resistance of CMOS latches to Cosmic Ray induced single event upsets. The sensor of the present invention can also be used to determine the uniformity of an ion beam.

  20. Synthesis of single phase. alpha. -Fe, Fe sub 3 C and Fe sub 7 C sub 3 nano-particles by CO sub 2 laser pyrolysis technique

    SciTech Connect

    Eklund, P.C.; Bi, X.X.

    1992-01-01

    Iron-containing catalysts have been known to be useful in assisting the Fischer-Tropsch (FT) reaction for synthesizing hydrocarbons. However, it has been well recognized that iron catalyst are not stable during the reaction but converted into iron carbides. It is thus important to understand the role of the iron carbides in the catalytic reaction of the FT-synthesis. It has been found difficult to produce iron carbide nano-particles as a single phase, because iron carbide phases are only metastable under 1 atm pressure. Iron carbide bulk particles prepared so far are often contaminated with metallic iron, iron oxides and free carbon. In this study, we investigate the synthesis of iron carbide nano-particles using CO{sub 2} laser pyrolysis technique. We show that this technique is successful in synthesizing {alpha}-Fe, Fe{sub 3}C and Fe{sub 7}C{sub 3} nano-particles in their single phase with sizes in the range of 5--20nm. In particular, we have produced for the first time the Fe{sub 7}C{sub 3} which has been known to exist but unable to be produced as a single phase. Furthermore, it is interesting that Fe{sub 5}C{sub 2} which has carbon and iron ratio between Fe{sub 3}C and Fe{sub 7}C{sub 3}, is not seen in any run of our synthesis.

  1. The Particle Adventure

    NSDL National Science Digital Library

    The US Department of Energy, National Science Foundation (NSF), and Lawrence Berkeley National Laboratory (LBNL) cosponsor the Particle Data Group. This group makes available the Particle Adventure Website, an "interactive tour of the inner workings of the atom." This site provides a very brief introduction to the theory of fundamental particles and forces, and particle decay. Different paths such as Particle Adventure Preview Movie (QuickTime format), Standard Model Path, Experimental Evidence Path, and Beyond the Standard Model Path explain how the matter of the universe interacts. Other features included at the site are the Complete Menu (table of contents and search tools), Why do Atoms and Particles Decay, Classroom Particle Physics Activities, and the History of Particle Physics, among others. Links to other educational particle physics educational sites are also available. This site is also available in Spanish, Polish, and French.

  2. Laser particle sorter

    DOEpatents

    Martin, John C. (Los Alamos, NM); Buican, Tudor N. (Los Alamos, NM)

    1989-01-01

    Method and apparatus for sorting particles, such as biological particles. A first laser defines an optical path having an intensity gradient which is effective to propel the particles along the path but which is sufficiently weak that the particles are not trapped in an axial direction. A probe laser beam interrogates the particles to identify predetermined phenotypical characteristics of the particles. A second laser beam intersects the driving first laser beam, wherein the second laser beam is activated by an output signal indicative of a predetermined characteristic. The second laser beam is switchable between a first intensity and a second intensity, where the first intensity is effective to displace selected particles from the driving laser beam and the second intensity is effective to propel selected particles along the deflection laser beam. The selected particles may then be propelled by the deflection beam to a location effective for further analysis.

  3. Particles in the wake of other particles

    NASA Astrophysics Data System (ADS)

    Block, Dietmar; Miloch, Wojciech Jacek

    2013-10-01

    The charging of dust grains in the wake of another grains in sonic and supersonic collisionless plasma flows is studied by numerical simulations. The simulations are carried out with DiP3D, a three dimensional particle-in-cell code with both electrons and ions represented as numerical particles. We consider two grains aligned with the flow, as well as dust chains and multiple grain arrangements. It is found that the dust charge depends significantly on the flow speed, distance between the grains, and the grain arrangement. Special attention is paid to typical experimental situations like a particle below a layer of particles and small 3D clusters. The charging of dust grains in the wake of another grains in sonic and supersonic collisionless plasma flows is studied by numerical simulations. The simulations are carried out with DiP3D, a three dimensional particle-in-cell code with both electrons and ions represented as numerical particles. We consider two grains aligned with the flow, as well as dust chains and multiple grain arrangements. It is found that the dust charge depends significantly on the flow speed, distance between the grains, and the grain arrangement. Special attention is paid to typical experimental situations like a particle below a layer of particles and small 3D clusters. Funded by DFG in the framework of the SFB TR24 project A3.

  4. Energetic particle physics issues for ITER

    SciTech Connect

    Cheng, C.Z.; Budny, R.; Fu, G.Y. [and others

    1996-12-31

    This paper summarizes our present understanding of the following energetic/alpha particle physics issues for the 21 MA, 20 TF coil ITER Interim Design configuration and operational scenarios: (a) toroidal field ripple effects on alpha particle confinement, (b) energetic particle interaction with low frequency MHD modes, (c) energetic particle excitation of toroidal Alfven eigenmodes, and (d) energetic particle transport due to MHD modes. TF ripple effects on alpha loss in ITER under a number of different operating conditions are found to be small with a maximum loss of 1%. With careful plasma control in ITER reversed-shear operation, TF ripple induced alpha loss can be reduced to below the nominal ITER design limit of 5%. Fishbone modes are expected to be unstable for {beta}{sub {alpha}} > 1%, and sawtooth stabilization is lost if the ideal kink growth rate exceeds 10% of the deeply trapped alpha precessional drift frequency evaluated at the q = 1 surface. However, it is expected that the fishbone modes will lead only to a local flattening of the alpha profile due to small banana size. MHD modes observed during slow decrease of stored energy after fast partial electron temperature collapse in JT-60U reversed-shear experiments may be resonant type instabilities; they may have implications on the energetic particle confinement in ITER reversed-shear operation. From the results of various TAE stability code calculations, ITER equilibria appear to lie close to TAE linear stability thresholds. However, the prognosis depends strongly on q profile and profiles of alpha and other high energy particles species. If TAE modes are unstable in ITER, the stochastic diffusion is the main loss mechanism, which scales with ({delta}B{sub r}/B){sup 2}, because of the relatively small alpha particle banana orbit size. For isolated TAE modes the particle loss is very small, and TAE modes saturate via the resonant wave-particle trapping process at very small amplitude.

  5. {alpha}-particle production: Direct and compound contribution in the reaction {sup 7}Li+{sup 28}Si at near-barrier energies

    SciTech Connect

    Pakou, A.; Nicolis, N.G.; Papachristodoulou, C. [Department of Physics, The University of Ioannina, GR-45110 Ioannina (Greece); Rusek, K. [Department of Nuclear Reactions, The Andrzej Soltan Institute for Nuclear Studies, Hoza 69, PL-00-681 Warsaw (Poland); Alamanos, N.; Gillibert, A.; Pollacco, E.C. [DSM/DAPNIA CEA SACLAY, F-91191 Gif-sur-Yvette (France); Doukelis, G. [Technical Educational Institute of Athens, GR-12210 Athens (Greece); Kalyva, G.; Lagoyannis, A.; Perdikakis, G.; Spyrou, A.; Zarkadas, Ch. [National Research Center, Demokritos (Greece); Kokkoris, M. [National Technical University of Athens, Athens (Greece); Musumarra, A. [Dipartimento di Metodologie Fisiche e Chimiche per l'Ingegneria dell'Universita di Catania, Catania (Italy); Pierroutsakou, D. [INFN Sezione di Napoli, I-80125 Naples (Italy)

    2005-06-01

    The production of {alpha} particles in the {sup 7}Li+{sup 28}Si reaction was studied at near-barrier energies. Angular distributions were measured at four energies, namely 9, 10, 11, and 13 MeV. The data were treated in a statistical model and DWBA framework to disentangle the degree of competition between direct and compound channels in the reaction and its energy evolution near the barrier. It was found that whereas the compound mechanism is substantial, d transfer and possibly t transfer are the dominant mechanism at near-barrier energies. The influence of the reaction channels on the optical potential threshold anomaly is discussed.

  6. A mechanism of variation in the electrical properties of polycrystalline p-PbSe films as a result of irradiation with {alpha} particles

    SciTech Connect

    Salii, Ya. P. [Stefanik Carpathian-region National University (Ukraine)

    2006-02-15

    The effect of irradiation with 5.5-MeV {alpha} particles on the electrical properties of polycrystalline p-PbSe films is studied. It is found that the concentration (p) and mobility ({mu}) of charge carriers decreases as a result of irradiation. The linear dependence of p and {mu}{sup -1} on the square root of the integrated flux {phi}{sup 1/2} is accounted for on the assumption that interstitial atoms in both sublattices are captured by intrinsic extended defects (dislocations and grain boundaries)

  7. Collective relaxation, single particle motion and short range order in. cap alpha. '-NbD/sub x/: A quasielastic neutron scattering study

    SciTech Connect

    Hempelmann, R.; Richter, D.; Faux, D.A.; Ross, D.K.

    1988-01-01

    Applying both incoherent and coherent quasielastic neutron scattering we have studied simultaneously single particle motion, collective relaxation and short range order of deuterium in ..cap alpha..'-NbD/sub x/. A comparison with recent Monte Carlo simulations lead to a consistent description of all results in terms of strongly repulsive deuterium-deuterium interactions. Relating the independently determined tracer and chemical diffusion coefficients with the also measured structure factor we show experimentally that for lattice gases the de Gennes narrowing Ansatz needs to be modified by correlation factors. 18 refs., 3 figs., 1 tab.

  8. The use of alpha particle tagged neutrons for the inspection of objects on the sea floor for the presence of explosives

    NASA Astrophysics Data System (ADS)

    Valkovic, V.; Sudac, D.; Obhodas, J.; Eleon, C.; Perot, B.; Carasco, C.; Sannié, G.; Boudergui, K.; Kondrasovs, V.; Corre, G.; Normand, S.; Woo, R.; Bourbotte, J. M.

    2013-03-01

    A system using a neutron sensor installed within a Remotely Operated Vehicle (ROV) for underwater inspection has been developed. The system can inspect objects for the presence of threat materials, such as explosives and chemical agents, by using alpha particle tagged neutrons from a sealed tube d+t neutron generator to produce characteristic gamma rays within the interrogated object. Here we show that the measured gamma spectra for commonly found ammunition charged with TNT explosives are dominated by C, O and Fe peaks enabling the underwater determination of explosives inside an ammunition shell.

  9. 1Carl Gagliardi Modern Particle

    E-print Network

    Boas, Harold P.

    ! Gold nucleus Charge = +79 Lead nucleus Charge = +82 We need another trick! #12;11Carl Gagliardi Another of light. · Can penetrate to the nucleus of essentially any atom up to lead Alpha particle Charge = +2 Lead Not Useful for Reactions with Heavy Nuclei · Can accelerate gold nuclei to ~200 MeV, but this is only ~1 Me

  10. Wave mechanics of particle detectors

    Microsoft Academic Search

    A. A. Broyles

    1993-01-01

    The operations of many detection devices are usually explained in terms of the ionization tracks produced by classical charged particles. A wave-mechanical analysis does not seem to be available. Mott [Proc. R. Soc. London Ser. A 126, 79 (1929)] has shown that an incident alpha wave emitted by a radioactive nucleus would be scattered by atoms primarily in directions almost

  11. Formation of the isomeric pair {sup 194}Ir{sup m,g} in interactions of {alpha} particles with {sup 192}Os

    SciTech Connect

    Uddin, M. S.; Qaim, S. M. [Institut fuer Neurowissenschaften und Medizin, INM-5: Nuklearchemie, Forschungszentrum Juelich, D-52425 Juelich (Germany); Sudar, S. [Institut fuer Neurowissenschaften und Medizin, INM-5: Nuklearchemie, Forschungszentrum Juelich, D-52425 Juelich (Germany); Institute of Experimental Physics, Debrecen University, H-4001 Debrecen (Hungary)

    2011-08-15

    Cross sections were measured by the activation technique for the nuclear processes {sup 192}Os({alpha},d+pn+np){sup 194}Ir{sup m,g} up to {alpha}-particle energies of 39 MeV. From the measured data the isomeric cross-section ratio was deduced as a function of projectile energy. The present experimental data as well as those for the {sup 194}Pt(n,p){sup 194}Ir{sup m,g} reaction, given in the literature, were compared with the results of nuclear model calculations using the code talys, which combines the statistical, precompound, and direct interactions. In general, the experimental data were reproduced well by the model calculations, which were done using relatively low values of {eta} (i.e., {Theta}{sub eff}/{Theta}{sub rigid}). The results provide more evidence for the mass dependence of {eta}. The level density parameter for {sup 194}Ir was determined unambiguously.

  12. Pileup per particle identification

    E-print Network

    Bertolini, Daniele

    We propose a new method for pileup mitigation by implementing “pileup per particle identification” (PUPPI). For each particle we first define a local shape ? which probes the collinear versus soft diffuse structure in the ...

  13. HZE-particle dosimetry

    Microsoft Academic Search

    D. D. Peterson; E. V. Benton; M. Tran

    1978-01-01

    An experiment designed to measure high-LET particle radiation on board the COSMOS 782 satellite is described. Plastic nuclear track detectors were used to measure flux, integral LET spectrum, charge distribution, and stopping density of high-LET particles.

  14. Acoustic particle separation

    NASA Technical Reports Server (NTRS)

    Barmatz, M. B.; Stoneburner, J. D.; Jacobi, N.; Wang, T. (inventors)

    1985-01-01

    A method is described which uses acoustic energy to separate particles of different sizes, densities, or the like. The method includes applying acoustic energy resonant to a chamber containing a liquid of gaseous medium to set up a standing wave pattern that includes a force potential well wherein particles within the well are urged towards the center, or position of minimum force potential. A group of particles to be separated is placed in the chamber, while a non-acoustic force such as gravity is applied, so that the particles separate with the larger or denser particles moving away from the center of the well to a position near its edge and progressively smaller lighter particles moving progressively closer to the center of the well. Particles are removed from different positions within the well, so that particles are separated according to the positions they occupy in the well.

  15. Charged Particle Flux Sensor

    NASA Technical Reports Server (NTRS)

    Gregory, D. A.; Stocks, C. D.

    1983-01-01

    Improved version of Faraday cup increases accuracy of measurements of flux density of charged particles incident along axis through collection aperture. Geometry of cone-and-sensing cup combination assures most particles are trapped.

  16. High energy particle astronomy.

    NASA Technical Reports Server (NTRS)

    Buffington, A.; Muller, R. A.; Smith, L. H.; Smoot, G. F.

    1972-01-01

    Discussion of techniques currently used in high energy particle astronomy for measuring charged and neutral cosmic rays and their isotope and momentum distribution. Derived from methods developed for accelerator experiments in particle physics, these techniques help perform important particle astronomy experiments pertaining to nuclear cosmic ray and gamma ray research, electron and position probes, and antimatter searches.

  17. Particle charge spectrometer

    NASA Technical Reports Server (NTRS)

    Fuerstenau, Stephen D. (Inventor)

    2004-01-01

    An airflow through a tube is used to guide a charged particle through the tube. A detector may be used to detect charge passing through the tube on the particle. The movement of the particle through the tube may be used to both detect its charge and size.

  18. When is a Particle?

    ERIC Educational Resources Information Center

    Drell, Sidney D.

    1978-01-01

    Gives a new definition for the concept of the elementary particle in nuclear physics. Explains why the existance of the quark as an elementary particle could be an accepted fact even though it lacks what traditionally identifies a particle. Compares this with the development which took place during the discovery of the neutrino in the early…

  19. Single and multiple cross sections for ionizing processes of biological molecules by protons and alpha-particle impact: a classical Monte Carlo approach.

    PubMed

    Abbas, I; Champion, C; Zarour, B; Lasri, B; Hanssen, J

    2008-02-21

    A classical trajectory model has been used to predict total cross sections of single and double ionizing processes (including capture processes) for several ion-biological molecule collisional systems in the intermediate and high energy range. In this work, the systems studied are water, adenine or cytosine targets ionized by protons and alpha-particles with kinetic energies ranging from 25 keV amu(-1) to 3000 keV amu(-1). In our approach, we have combined several features of two classical methods namely the classical trajectory Monte Carlo (CTMC) and the classical over-barrier (COB) models. For the water target, our results are compared, for high kinetic energies of incident particles, to the available experimental and theoretical results, and reasonable agreement are generally observed especially for the single ionization (liberated electron moves freely after the collision) and the single capture (liberated electron captured by the projectile), both processes representing ionizing processes. Considering the double ionizing processes which have been largely less studied, the unique comparison concerns the double capture process for alpha+H(2)O collision for which we reproduce the experiment reasonably well. Finally, we present total cross sections of single and double ionizing processes for biological targets such as adenine and cytosine where no experimental results exist till now. PMID:18263940

  20. Do the various radiations present in BNCT act synergistically? Cell survival experiments in mixed alpha-particle and gamma-ray fields.

    PubMed

    Phoenix, Ben; Green, Stuart; Hill, Mark A; Jones, Bleddyn; Mill, Andrew; Stevens, David L

    2009-07-01

    In many radiotherapy situations patients are exposed to mixed field radiation. In particular in BNCT, as with all neutron beam exposures, a significant fraction of the dose is contributed by low LET gamma ray photons. The components of such a mixed field may show a synergistic interaction and produce a greater cell kill effect than would be anticipated from the independent action of the different radiation types. Such a synergy would have important implications for treatment planning and in the interpretation of clinical results. An irradiation setup has been created at the Medical Research Council in Harwell to allow simultaneous irradiation of cells by cobalt-60 gamma rays and plutonium-238 alpha-particles. The setup allows for variation of dose and dose rates for both sources along with variation of the alpha particle energy. A series of cell survival assays for this mixed field have been carried out using V79-4 cells and compared to exposures to the individual components of the field under identical conditions. In the experimental setup described no significant synergistic effect was observed. PMID:19376715

  1. Activation cross sections of $\\alpha$-particle induced nuclear reactions on hafnium and deuteron induced nuclear reaction on tantalum: production of $^{178}$W/$^{178m}$Ta generator

    E-print Network

    Tárk'anyi, F; Ditrói, F; Hermanne, A; Ignatyuk, A V; Uddin, M S

    2014-01-01

    In the frame of a systematic study of charged particle production routes of medically relevant radionuclei, the excitation function for indirect production of $^{178m}$Ta through $^{nat}$Hf($\\alpha$,xn)$^{178}$W-$^{178m}$Ta nuclear reaction was measured for the first time up to 40 MeV. In parallel, the side reactions $^{nat}$Hf($\\alpha$,x)$^{179,177,176,175}$W, $^{183,182,178g,177,176,175}$Ta, $^{179m,177m,175}$Hf were also assessed. Stacked foil irradiation technique and $\\gamma$-ray spectrometry were used. New experimental cross section data for the $^{nat}$Ta(d,xn)$^{178}$W reaction are also reported up to 40 MeV. The measured excitation functions are compared with the results of the ALICE-IPPE, and EMPIRE nuclear reaction model codes and with the TALYS 1.4 based data in the TENDL-2013 library. The thick target yields were deduced and compared with yields of other charged particle ((p,4n), (d,5n) and ($^3$He,x)) production routes for $^{178}$W.

  2. High speed imaging system in continuum and H-alpha at the Hida observatory for the study of high energy particles in solar flares

    NASA Astrophysics Data System (ADS)

    Ichimoto, K.; Kawate, T.; Yoshikazu, N.; Ishii, T.; Nagata, S.; Asai, A.; Masuda, S.; Kusano, K.; Yamamoto, T. T.; Minoshima, T.; Yokoyama, T.; Watanabe, K.

    2011-12-01

    Non-thermal particles are the fundamental ingredient of solar flares that carry the bulk energy released from the coronal magnetic fields and cause subsequent heating of the solar atmosphere to produce the radiation of wide range of electro-magnetic waves. The observations of hard X-ray and radio emissions suggest a rapid change of population of high energy particles with a time scale of sub-second. Flare kernels observed in visible lights, ex., H-alpha and continuum, show drastic evolutions in space and time during the rising phase of solar flares, and thought to be representing the locations of the precipitation of high energy particles into the chromosphere. Therefore the observations of flare kernels with high spatial and temporal resolutions provide valuable diagnosis of the distribution of high energy particles together with the information of connectivity of coronal magnetic fields. We developed a new high speed imaging system on a 25cm diameter telescope of the Solar Magnetic Activity Research Telescope (SMART) at the Hida observatory of Kyoto University. Images in H-alpha (width~3A) and continuum (6547A, width~10A) are recorded simultaneously with two CCD cameras with a spatial sampling of 0.2 arcsec/pix, field coverage of 344 arcsec x 258 arcsec, and a frame rate of 30fr/sec. Observation is conducted continuously by focusing a targeted active region every day, while only data sets that capture flare events are permanently stored for further analysis. The spatial and temporal evolutions of flare kernels thus obtained are combined with photospheric vector magnetic field taken by the SMART, SOT/Hinode and HMI/SDO, radio data by NoRH, hard X-ray image by RHESSI, and X-ray / UV images by SXT/Hinode and AIA/SDO to identify the instantaneous locations of high energy particles injection in the corona. In this paper we will present an overview of the observing system and its initial results. This work was carried out by the joint research program of the Solar-Terrestorial Environment Laboratory, Nagoya University.

  3. Particle separator scroll vanes

    SciTech Connect

    Lastrina, F. A.; Mayer, J. C.; Pommer, L. M.

    1985-07-09

    An inlet particle separator for a gas turbine engine is provided with unique vanes distributed around an entrance to a particle collection chamber. The vanes are uniquely constructed to direct extraneous particles that enter the engine into the collection chamber and prevent the particles from rebounding back into the engine's air flow stream. The vanes are provided with several features to accomplish this function, including upstream faces that are sharply angled towards air flow stream direction to cause particles to bounce towards the collection chamber. In addition, throat regions between the vanes cause a localized air flow acceleration and a focusing of the particles that aid in directing the particles in a proper direction.

  4. Adhesive particle shielding

    DOEpatents

    Klebanoff, Leonard Elliott (Dublin, CA); Rader, Daniel John (Albuquerque, NM); Walton, Christopher (Berkeley, CA); Folta, James (Livermore, CA)

    2009-01-06

    An efficient device for capturing fast moving particles has an adhesive particle shield that includes (i) a mounting panel and (ii) a film that is attached to the mounting panel wherein the outer surface of the film has an adhesive coating disposed thereon to capture particles contacting the outer surface. The shield can be employed to maintain a substantially particle free environment such as in photolithographic systems having critical surfaces, such as wafers, masks, and optics and in the tools used to make these components, that are sensitive to particle contamination. The shield can be portable to be positioned in hard-to-reach areas of a photolithography machine. The adhesive particle shield can incorporate cooling means to attract particles via the thermophoresis effect.

  5. Simulation of particle agglomeration using dissipative particle dynamics

    E-print Network

    Mokkapati, Srinivas Praveen

    2009-05-15

    Attachment of particles to one another due to action of certain inter-particle forces is called as particle agglomeration. It has applications ranging from efficient capture of ultra-fine particles generated in coal-burning boilers to effective...

  6. Fabrication of high resolution n-type 4H-SiC epitaxial layer alpha particle detectors, defect characterization and electronic noise analysis

    NASA Astrophysics Data System (ADS)

    Zavalla, Kelvin J.; Chaudhuri, Sandeep K.; Mandal, Krishna C.

    2013-09-01

    In the present work high-resolution alpha particle detectors have been fabricated on high quality 20 ?m thick n-type 4H-SiC epitaxial layers. Schottky barrier detectors have been fabricated by depositing 10 nm thick nickel contacts on the Si face of the epilayers. The detectors were characterized using current-voltage (I-V), capacitance-voltage (CV), alpha spectroscopic measurements, and deep level transient spectroscopy (DLTS). I-V measurements revealed a barrier height of ~1.6 eV, diode ideality factor of 1.09, and leakage current of the order of 14 pA at an operating bias of 110 V. C-V measurements revealed low effective doping concentrations of 3.1 × 1014 cm-3 in the epilayers. A micropipe density lower than 1 cm-2 was evaluated in the epilayers. Pulse-height spectroscopy exhibited energy resolution as high as 0.37 % for 5.48 MeV alpha particles with a detector active area of 11 mm2. A diffusion length of ~13.2 ?m for holes has been determined in these detectors following a calculation based on a drift-diffusion model. Detailed electronic noise analysis in terms of equivalent noise charge (ENC) was carried out to study the effect of various noise components that contribute to the total electronic noise in the detection system. The noise analysis revealed that the white series noise due to the detector capacitance has substantial effect on the detector's overall performance. DLTS measurements have revealed the presence of at least four majority (electron) carrier trap levels that can act as recombination/generation or trapping centers.

  7. Cadmium zinc telluride charged particle nuclear detectors

    SciTech Connect

    Toney, J.E. [Sandia National Labs., Livermore, CA (United States)]|[Carnegie Mellon Univ., Pittsburgh, PA (United States); James, R.B.; Antolak, A. [Sandia National Labs., Livermore, CA (United States)] [and others

    1997-02-01

    This report describes the improvements in understanding of transport phenomena in cadmium zinc telluride radiation sensors achieved through studies of alpha particle response and spatially resolved photoconductivity mapping. Alpha particle response waveforms and photocurrent profiles both indicate non-uniformities in the electric field which may have detrimental effects on detector performance. Identifying and eliminating the sources of these nonuniformities will ultimately lead to improved detector performance.

  8. Precision gap particle separator

    DOEpatents

    Benett, William J.; Miles, Robin; Jones, II., Leslie M.; Stockton, Cheryl

    2004-06-08

    A system for separating particles entrained in a fluid includes a base with a first channel and a second channel. A precision gap connects the first channel and the second channel. The precision gap is of a size that allows small particles to pass from the first channel into the second channel and prevents large particles from the first channel into the second channel. A cover is positioned over the base unit, the first channel, the precision gap, and the second channel. An port directs the fluid containing the entrained particles into the first channel. An output port directs the large particles out of the first channel. A port connected to the second channel directs the small particles out of the second channel.

  9. Particle Swarm Optimization

    NASA Technical Reports Server (NTRS)

    Venter, Gerhard; Sobieszczanski-Sobieski Jaroslaw

    2002-01-01

    The purpose of this paper is to show how the search algorithm known as particle swarm optimization performs. Here, particle swarm optimization is applied to structural design problems, but the method has a much wider range of possible applications. The paper's new contributions are improvements to the particle swarm optimization algorithm and conclusions and recommendations as to the utility of the algorithm, Results of numerical experiments for both continuous and discrete applications are presented in the paper. The results indicate that the particle swarm optimization algorithm does locate the constrained minimum design in continuous applications with very good precision, albeit at a much higher computational cost than that of a typical gradient based optimizer. However, the true potential of particle swarm optimization is primarily in applications with discrete and/or discontinuous functions and variables. Additionally, particle swarm optimization has the potential of efficient computation with very large numbers of concurrently operating processors.

  10. Modeling an HIV Particle

    NSDL National Science Digital Library

    2013-05-15

    This activity helps learners visualize the Human Immunodeficiency Virus (HIV) by constructing three-dimensional HIV particle models from paper. The model to be used is a 20-sided polyhedron (icosahedron) and represents a complete viral particle. Learners combine their finished models into one mass. This is a first step toward estimating how many HIV particles could be contained inside a white blood cell before being released into the blood stream to attack new cells.

  11. Analysis of boron by charged particle bombardment

    Microsoft Academic Search

    N. Moncoffre

    1992-01-01

    The determination of boron concentration in thin films, semiconductors or other materials requires techniques providing good depth resolution and high sensitivities. For this purpose nuclear analysis techniques can be powerful tools and this paper presents a review of the nuclear reactions essentially with charged particles (p, alpha, d) that have been used (including charge particle activation analysis). Irradiation with neutrons

  12. Unstable Particles near Threshold

    E-print Network

    Dongjin Chway; Tae Hyun Jung; Hyung Do Kim

    2015-02-12

    We explore physics of unstable particles when mother particle mass is around the sum of its daughter particle masses. In this case, the conventional wave function renormalization factor is ill-defined. We propose a simple resolution of the threshold singularity problem which still allows the use of narrow width approximation by defining branching ratio in terms of spectral density. The resonance peak and shape is different for different decay channels and no single decay width can be assigned to the unstable particles. Non-exponential decay happens in all time scales.

  13. Bioactivation of particles

    DOEpatents

    Pinaud, Fabien (Berkeley, CA); King, David (San Francisco, CA); Weiss, Shimon (Los Angeles, CA)

    2011-08-16

    Particles are bioactivated by attaching bioactivation peptides to the particle surface. The bioactivation peptides are peptide-based compounds that impart one or more biologically important functions to the particles. Each bioactivation peptide includes a molecular or surface recognition part that binds with the surface of the particle and one or more functional parts. The surface recognition part includes an amino-end and a carboxy-end and is composed of one or more hydrophobic spacers and one or more binding clusters. The functional part(s) is attached to the surface recognition part at the amino-end and/or said carboxy-end.

  14. Suppression of the Critical Temperature of Superconducting NdFeAs(OF) Single Crystals by Kondo-Like Defect Sites Induced by {alpha}-Particle Irradiation

    SciTech Connect

    Tarantini, C.; Gurevich, A.; Larbalestier, D. C. [National High Magnetic Field Laboratory, Florida State University, Tallahassee, 32310 Florida (United States); Putti, M. [CNR-SPIN and Department of Physics, University of Genova, 16146 Genova (Italy); Shen, Y.; Singh, R. K.; Rowell, J. M.; Newman, N. [Department of Materials Science and Engineering, Arizona State University, Tempe, 85287 Arizona (United States); Cheng Peng; Jia Ying; Wen Haihu [Institute of Physics and National Laboratory of Condensed Matter Physics, Chinese Academy of Sciences, 100190 Beijing (China)

    2010-02-26

    We report the effect of {alpha}-particle irradiation on the reduction of the critical temperature T{sub c} of a NdFeAs(OF) single crystal. Our data indicate that irradiation defects cause both nonmagnetic and magnetic scattering, resulting in the Kondo-like excess resistance {Delta}{rho}(T)propor tolnT over 2 decades in temperatures above T{sub c}. The critical density of magnetic irradiation defects which suppresses T{sub c} is found to be much higher than those for cuprates and multiband BCS superconductors. We suggest that such anomalously weak pair breaking by irradiation defects indicates that magnetic scattering in pnictides is coupled with pairing interactions mediated by spin fluctuations.

  15. Scaling of cross sections for K-electron capture by high-energy protons and alpha-particles from the multielectron atoms

    NASA Technical Reports Server (NTRS)

    Omidvar, K.

    1976-01-01

    Electron capture by protons from H, He, and the K-shell of Ar, and alpha particles from He are considered. It is shown that when a certain function of the experimental cross sections is plotted versus the inverse of the collision energy, at high energies the function falls on a straight line. At lower energies the function concaves up or down, depending on the charge of the projectile, the effective charge and the ionization potential of the electron that is being captured. The plot can be used to predict cross sections where experimental data are not available, and as a guide in future experiments. High energy scaling formulas for K-electron capture by low-charge projectiles are given.

  16. Development of a strongly focusing high-intensity He{sup +} ion source for a confined alpha particle measurement at ITER

    SciTech Connect

    Kisaki, M.; Shinto, K.; Kobuchi, T.; Okamoto, A.; Kitajima, S.; Sasao, M.; Tsumori, K.; Nishiura, M.; Kaneko, O.; Matsuda, Y.; Wada, M.; Sakakita, H.; Kiyama, S.; Hirano, Y. [School of Engineering, Tohoku University, Sendai 980-0579 (Japan); National Institute for Fusion Science, Toki, Gifu 509-5292 (Japan); Department of Electronics, Doshisha University, Kyotanabe, Kyoto 610-0321 (Japan); National Institute of Advanced Industrial Science and Technology, Tsukuba 305-8568 (Japan)

    2008-02-15

    A strongly focusing high-intensity He{sup +} ion source has been designed and constructed as a beam source for a high-energy He{sup 0} beam probe system for diagnosis of fusion produced alpha particles in the thermonuclear fusion plasmas. The He{sup +} beam was extracted from the ion source at an acceleration voltage of 18-35 kV. Temperature distributions of the beam target were observed with an IR camera. The 1/e-holding beam profile half-width was about 15 mm at optimum perveance (Perv) of 0.03 (I{sub beam}=2.4 A). A beam current about 3 A was achieved at an acceleration voltage of 26.7 kV with an arc power of 10 kW (Perv=0.023)

  17. Development of a He{sup -} and He{sup 0} beam source for alpha particle measurement in a burning plasma

    SciTech Connect

    Tanaka, N.; Sasao, M.; Terai, K.; Okamoto, A.; Kitajima, S. [Tohoku University, Aoba, Sendai 980-8579 (Japan); Yamaoka, H. [Harima Institute, RIKEN, Sayo, Hyogo 679-5148 (Japan); Wada, M. [Doshisha University, Kyotanabe, Kyoto 610-0321 (Japan)

    2012-02-15

    Proof of principle experiments of neutral helium beam production for alpha particle diagnostics was carried out on a test stand. Negative helium ions were produced in the Li charge exchange cell, in which stable and long time operation was possible. He{sup -} beam was accelerated to 157 keV. Finally, He{sup 0} beam was successfully produced after the flight in the drift-tube through the auto-electron-detachment process from He{sup -} to He{sup 0}. A neutral beam detector using a pyroelectric device was also developed to measure He{sup 0} beam intensity. The metastable component in the neutral helium beam was found to be less than 2%.

  18. Associated particle imaging (API)

    SciTech Connect

    NONE

    1998-05-01

    Associated Particle Imaging (API) is an active neutron probe technique that provides a 3-D image with elemental composition of the material under interrogation, and so occupies a unique niche in the interrogation of unknown objects. The highly penetrating nature of neutrons enables API to provide detailed information about targets of interest that are hidden from view. Due to the isotropic nature of the induced reactions, radiation detectors can be set on the same side of the object as the neutron source, so that the object can be interrogated from a single side. At the heat of the system is a small generator that produces a continuous, monoenergetic flux of neutrons. By measuring the trajectory of coincident alpha particles that are produced as part of the process, the trajectory of the neutron can be inferred. Interactions between a neutron and the material in its path often produce a gamma ray whose energy is characteristic of that material. When the gamma ray is detected, its energy is measured and combined with the trajectory information to produce a 3-D image of the composition of the object being interrogated. During the course of API development, a number of improvements have been made. A new, more rugged sealed Tube Neutron Generator (STNG) has been designed and fabricated that is less susceptible to radiation damage and better able to withstand the rigors of fielding than earlier designs. A specialized high-voltage power supply for the STNG has also been designed and built. A complete package of software has been written for the tasks of system calibration, diagnostics and data acquisition and analysis. A portable system has been built and field tested, proving that API can be taken out of the lab and into real-world situations, and that its performance in the field is equal to that in the lab.

  19. Evaluation of internal alpha-particle radiation exposure and subsequent fertility among a cohort of women formerly employed in the radium dial industry.

    PubMed

    Schieve, L A; Davis, F; Roeske, J; Handler, A; Freels, S; Stinchcomb, T; Keane, A

    1997-02-01

    This study examined the effect of internal exposure to alpha-particle radiation on subsequent fertility among women employed in the radium dial industry prior to 1930, when appreciable amounts of radium were often ingested through the practice of pointing the paint brush with the lips. The analysis was limited to women for whom a radium body burden measurement had been obtained and who were married prior to age 45 (n = 603). Internal radiation dose to the ovary was calculated based on initial intakes of radium-226 and radium-228, average ovarian mass, number and energy of alpha particles emitted, fraction of energy absorbed within the ovary, effective retention integrals and estimated photon irradiation. Time between marriage and pregnancy, number of pregnancies and number of live births served as surrogates for fertility. Radiation appeared to have no effect on fertility at estimated cumulative ovarian dose equivalents below 5 Sv; above this dose, however, statistically significant declines in both number of pregnancies and live births were observed. These trends persisted after multivariable adjustment for potential confounding variables and after exclusion of subjects contributing a potential classification or selection bias to the study. Additionally, the high-dose group experienced fewer live births than would have been expected based on population rates. There were no differences in time to first pregnancy between high- and low-dose groups. These results are consistent with earlier studies of gamma-ray exposures and suggest that exposure to high doses of radiation from internally deposited radium reduces fertility rather than inducing sterility. PMID:9008216

  20. Evaluation of internal alpha-particle radiation exposure and subsequent fertility among a cohort of women formerly employed in the radium dial industry

    SciTech Connect

    Schieve, L.A.; Davis, F.; Freels, S. [Univ. of Illinois, Chicago, IL (United States)] [and others

    1997-02-01

    This study examined the effect of internal exposure to {alpha}-particle radiation on subsequent fertility among women employed in radium dial industry prior to 1930, when appreciable amounts of radium were often ingested through the practice of pointing the paint brush with the lips. The analysis was limited to women for whom a radium body burden measurement had been obtained and who were married prior to age 45 (n = 603). Internal radiation dose to the ovary was calculated based on initial intakes of radium-226 and radium-228, average ovarian mass, number and energy of {alpha} particles emitted, fraction of energy absorbed within the ovary, effective retention integrals and estimated photon irradiation. Time between marriage and pregnancy, number of pregnancies and number of live births served as surrogates for fertility. Radiation appeared to have no effect on fertility at estimated cumulative ovarian dose equivalents below 5 Sv; above this dose, however, statistically significant declines in both number of pregnancies and live births were observed. These trends persisted after multivariable adjustment for potential confounding variables and after exclusion of subjects contributing a potential classification or selection bias to the study. Additionally, the high-dose group experienced fewer live births than would have been expected based on population rates. There were no differences in time to first pregnancy between high- and low-dose groups. These results are consistent with earlier studies of {gamma}-ray exposures and suggest that exposure to high doses of radiation from internally deposited radium reduces fertility rather than inducing sterility. 42 refs., 5 tabs.

  1. Alpha-Lipoic Acid Reduces LDL-Particle Number and PCSK9 Concentrations in High-Fat Fed Obese Zucker Rats

    PubMed Central

    Carrier, Bradley; Wen, Shin; Zigouras, Sophia; Browne, Richard W.; Li, Zhuyun; Patel, Mulchand S.; Williamson, David L.; Rideout, Todd C.

    2014-01-01

    We characterized the hypolipidemic effects of alpha-lipoic acid (LA, R-form) and examined the associated molecular mechanisms in a high fat fed Zucker rat model. Rats (n?=?8) were assigned to a high fat (HF) diet or the HF diet with 0.25% LA (HF-LA) for 30 days and pair fed to remove confounding effects associated with the anorectic properties of LA. Compared with the HF controls, the HF-LA group was protected against diet-induced obesity (102.5±3.1 vs. 121.5±3.6,% change BW) and hypercholesterolemia with a reduction in total-C (?21%), non-HDL-C (?25%), LDL-C (?16%), and total LDL particle number (?46%) and an increase in total HDL particles (?22%). This cholesterol-lowering response was associated with a reduction in plasma PCSK9 concentration (?70%) and an increase in hepatic LDLr receptor protein abundance (2 fold of HF). Compared with the HF-fed animals, livers of LA-supplemented animals were protected against TG accumulation (?46%), likely through multiple mechanisms including: a suppressed lipogenic response (down-regulation of hepatic acetyl-CoA carboxylase and fatty acid synthase expression); enhanced hepatic fat oxidation (increased carnitine palmitoyltransferase I? expression); and enhanced VLDL export (increased hepatic diacylglycerol acyltransferase and microsomal triglyceride transfer protein expression and elevated plasma VLDL particle number). Study results also support an enhanced fatty acid uptake (2.8 fold increase in total lipase activity) and oxidation (increased CPT1? protein abundance) in muscle tissue in LA-supplemented animals compared with the HF group. In summary, in the absence of a change in caloric intake, LA was effective in protecting against hypercholesterolemia and hepatic fat accumulation under conditions of strong genetic and dietary predisposition toward obesity and dyslipidemia. PMID:24595397

  2. Energetic particle experiment ERNE

    Microsoft Academic Search

    J. Torsti; E. Valtonen; M. Lumme; P. Peltonen; T. Eronen; M. Louhola; E. Riihonen; G. Schultz; M. Teittinen; K. Ahola; C. Holmlund; V. Kelhä; K. Leppälä; P. Ruuska; E. Strömmer

    1995-01-01

    The Energetic and Relativistic Nuclei and Electron (ERNE) experiment will investigate the solar atmosphere and the heliosphere by detecting particles produced in various kinds of energy release processes. ERNE is at the upper end in energy among the SOHO particle instruments. The instrument will measure the energy spectra of elements in the range Z=1–30. The energy coverage varies dependent on

  3. RESEARCH IN PARTICLE PHYSICS

    SciTech Connect

    Kearns, Edward [Boston Universiy] [Boston Universiy

    2013-07-12

    This is the final report for the Department of Energy Grant to Principal Investigators in Experimental and Theoretical Particle Physics at Boston University. The research performed was in the Energy Frontier at the LHC, the Intensity Frontier at Super-Kamiokande and T2K, the Cosmic Frontier and detector R&D in dark matter detector development, and in particle theory.

  4. Particle swarm optimization

    Microsoft Academic Search

    James N. Kennedy; Russell C. Eberhart

    1995-01-01

    A concept for the optimization of nonlinear functions using particle swarm methodology is introduced. The evolution of several paradigms is outlined, and an implementation of one of the paradigms is discussed. Benchmark testing of the paradigm is described, and applications, including nonlinear function optimization and neural network training, are proposed. The relationships between particle swarm optimization and both artificial life

  5. The Behavior of Particles

    Microsoft Academic Search

    James Kennedy

    1998-01-01

    The particle swarm algorithm has been shown to optimize a wide variety of complex functions. This paper examines a simplified version of the algorithm in an effort to understand the trajectories of particles as they search for solutions. Findings address optimal parameter values, point out issues for future research, and contribute to understanding this new optimization method.

  6. Interactive Terascale Particle Visualization

    NASA Technical Reports Server (NTRS)

    Ellsworth, David; Green, Bryan; Moran, Patrick

    2004-01-01

    This paper describes the methods used to produce an interactive visualization of a 2 TB computational fluid dynamics (CFD) data set using particle tracing (streaklines). We use the method introduced by Bruckschen et al. [2001] that pre-computes a large number of particles, stores them on disk using a space-filling curve ordering that minimizes seeks, and then retrieves and displays the particles according to the user's command. We describe how the particle computation can be performed using a PC cluster, how the algorithm can be adapted to work with a multi-block curvilinear mesh, and how the out-of-core visualization can be scaled to 296 billion particles while still achieving interactive performance on PG hardware. Compared to the earlier work, our data set size and total number of particles are an order of magnitude larger. We also describe a new compression technique that allows the lossless compression of the particles by 41% and speeds the particle retrieval by about 30%.

  7. Coherent Particle Scattering

    Microsoft Academic Search

    Eric Cummings

    2005-01-01

    The concept and modeling of coherent particle scattering (CPS) are presented. CPS is transport that arises from interactions of molecules with periodic, spatially non-uniform fields. CPS supports a variety of novel micro- and nanofluidic technologies including coherent nonlinear chromatography (CNC). CNC is a novel separation technique that promises ultra-rapid sorting of particles and molecules. Employing interactions with field nonuniformities in

  8. RESONATOR PARTICLE SEPARATOR

    Microsoft Academic Search

    J. P. Blewett; J. D. Kiesling

    1963-01-01

    A wave-guide resonator structure is designed for use in separating ; particles of equal momentum but differing in mass, having energies exceeding one ; billion eiectron volts. The particles referred to are those of sub-atomic size ; and are generally produced as a result of the bombardment of a target by a beam ; such as protons produced in a

  9. RESONATOR PARTICLE SEPARATOR

    Microsoft Academic Search

    1962-01-01

    A wave guide resonator structure is described for use in separating ; particles of equal momentum but differing in mass and having energies exceeding ; one billion electron volts. The particles are those of sub-atomic size and are ; generally produced as a result of the bombardment of a target by a beam such as ; protons produced in a

  10. Pileup per particle identification

    NASA Astrophysics Data System (ADS)

    Bertolini, Daniele; Harris, Philip; Low, Matthew; Tran, Nhan

    2014-10-01

    We propose a new method for pileup mitigation by implementing "pileup per particle identification" (PUPPI). For each particle we first define a local shape ? which probes the collinear versus soft diffuse structure in the neighborhood of the particle. The former is indicative of particles originating from the hard scatter and the latter of particles originating from pileup interactions. The distribution of ? for charged pileup, assumed as a proxy for all pileup, is used on an event-by-event basis to calculate a weight for each particle. The weights describe the degree to which particles are pileup-like and are used to rescale their four-momenta, superseding the need for jet-based corrections. Furthermore, the algorithm flexibly allows combination with other, possibly experimental, probabilistic information associated with particles such as vertexing and timing performance. We demonstrate the algorithm improves over existing methods by looking at jet p T and jet mass. We also find an improvement on non-jet quantities like missing transverse energy.

  11. Ambient Tropospheric Particles

    EPA Science Inventory

    Atmospheric particulate matter (PM) is a complex mixture of solid and liquid particles suspended in ambient air (also known as the atmospheric aerosol). Ambient PM arises from a wide-range of sources and/or processes, and consists of particles of different shapes, sizes, and com...

  12. Submicron particle sampler apparatus

    Microsoft Academic Search

    Don D. Gay; William G. McMillan

    1987-01-01

    Apparatus and method steps for collecting sub-micron sized particles include a collection chamber and cryogenic cooling. The cooling is accomplished by coil tubing carrying nitrogen in liquid form, with the liquid nitrogen changing to the gas phase before exiting from the collection chamber in the tubing. Standard filters are used to filter out particles of diameter greater than or equal

  13. Particle impact location detector

    NASA Technical Reports Server (NTRS)

    Auer, S. O.

    1974-01-01

    Detector includes delay lines connected to each detector surface strip. When several particles strike different strips simultaneously, pulses generated by each strip are time delayed by certain intervals. Delay time for each strip is known. By observing time delay in pulse, it is possible to locate strip that is struck by particle.

  14. DNA Double Strand Breaks as Predictor of Efficacy of the Alpha-Particle Emitter Ac-225 and the Electron Emitter Lu-177 for Somatostatin Receptor Targeted Radiotherapy

    PubMed Central

    Graf, Franziska; Fahrer, Jörg; Maus, Stephan; Morgenstern, Alfred; Bruchertseifer, Frank; Venkatachalam, Senthil; Fottner, Christian; Weber, Matthias M.; Huelsenbeck, Johannes; Schreckenberger, Mathias; Kaina, Bernd; Miederer, Matthias

    2014-01-01

    Rationale Key biologic effects of the alpha-particle emitter Actinium-225 in comparison to the beta-particle emitter Lutetium-177 labeled somatostatin-analogue DOTATOC in vitro and in vivo were studied to evaluate the significance of ?H2AX-foci formation. Methods To determine the relative biological effectiveness (RBE) between the two isotopes (as - biological consequence of different ionisation-densities along a particle-track), somatostatin expressing AR42J cells were incubated with Ac-225-DOTATOC and Lu-177-DOTATOC up to 48 h and viability was analyzed using the MTT assay. DNA double strand breaks (DSB) were quantified by immunofluorescence staining of ?H2AX-foci. Cell cycle was analyzed by flow cytometry. In vivo uptake of both radiolabeled somatostatin-analogues into subcutaneously growing AR42J tumors and the number of cells displaying ?H2AX-foci were measured. Therapeutic efficacy was assayed by monitoring tumor growth after treatment with activities estimated from in vitro cytotoxicity. Results Ac-225-DOTATOC resulted in ED50 values of 14 kBq/ml after 48 h, whereas Lu-177-DOTATOC displayed ED50 values of 10 MBq/ml. The number of DSB grew with increasing concentration of Ac-225-DOTATOC and similarly with Lu-177-DOTATOC when applying a factor of 700-fold higher activity compared to Ac-225. Already 24 h after incubation with 2.5–10 kBq/ml, Ac-225-DOTATOC cell-cycle studies showed up to a 60% increase in the percentage of tumor cells in G2/M phase. After 72 h an apoptotic subG1 peak was also detectable. Tumor uptake for both radio peptides at 48 h was identical (7.5%ID/g), though the overall number of cells with ?H2AX-foci was higher in tumors treated with 48 kBq Ac-225-DOTATOC compared to tumors treated with 30 MBq Lu-177-DOTATOC (35% vs. 21%). Tumors with a volume of 0.34 ml reached delayed exponential tumor growth after 25 days (44 kBq Ac-225-DOTATOC) and after 21 days (34 MBq Lu-177-DOTATOC). Conclusion ?H2AX-foci formation, triggered by beta- and alpha-irradiation, is an early key parameter in predicting response to internal radiotherapy. PMID:24516620

  15. Aggregation of anisotropic particles

    NASA Astrophysics Data System (ADS)

    Meakin, Paul; Chen, Zhong-Ying; Evesque, Pierre

    1987-07-01

    The diffusion limited aggregation of particles with anisotropic sticking probabilities has been investigated using computer models. All of our simulations have been carried out using 2d square lattices with square ``particles'' having two more sticky and two less sticky sides with sides of different kinds adjacent to each other. In both the limits of fast and slow particle rotation the anisotropy of the particles enhances the anisotropy of the square lattice and cross-shaped clusters (with side branches) are formed which resemble those generated by very much larger scale simulations of the regular DLA process. In the slow rotation limit a bias in the number of particles launched with sticky sides facing in the X or Y directions on the lattice leads to the formation of needle-shaped clusters whose radius of gyration (Rg) increases with cluster mass (M) according to Rg ˜M2/3.

  16. Sequential Cytarabine and Alpha-Particle Immunotherapy with Bismuth-213-Lintuzumab (HuM195) for Acute Myeloid Leukemia

    PubMed Central

    Rosenblat, Todd L.; McDevitt, Michael R.; Mulford, Deborah A.; Pandit-Taskar, Neeta; Divgi, Chaitanya R.; Panageas, Katherine S.; Heaney, Mark L.; Chanel, Suzanne; Morgenstern, Alfred; Sgouros, George; Larson, Steven M.; Scheinberg, David A.; Jurcic, Joseph G.

    2010-01-01

    Purpose Lintuzumab (HuM195), a humanized anti-CD33 antibody, targets myeloid leukemia cells and has modest single-agent activity against acute myeloid leukemia (AML). To increase the antibody’s potency without the nonspecific cytotoxicity associated with ?-emitters, the ? particle-emitting radionuclide bismuth-213 (213Bi) was conjugated to lintuzumab. This phase I/II trial was conducted to determine the maximum tolerated dose (MTD) and antileukemic effects of 213Bi-lintuzumab, the first targeted ?-emitter, after partially cytoreductive chemotherapy. Experimental Design Thirty-one patients with newly diagnosed (n = 13) or relapsed/refractory (n = 18) AML (median age, 67 years; range, 37–80) were treated with cytarabine 200 mg/m2/day for 5 days followed by 213Bi-lintuzumab 18.5–46.25 MBq/kg. Results The MTD of 213Bi-lintuzumab was 37 MB/kg; myelosuppression lasting > 35 days was dose-limiting. Extramedullary toxicities were primarily limited to ? grade 2 events, including infusion-related reactions. Transient grade 3/4 liver function abnormalities were seen in 5 patients (16%). Treatment-related deaths occurred in 2 of 21 patients (10%) who received the MTD. Significant reductions in marrow blasts were seen at all dose levels. The median response duration was 6 months (range, 2–12). Biodistribution and pharmacokinetic studies suggested that saturation of available CD33 sites by 213Bi-lintuzumab was achieved after partial cytoreduction with cytarabine. Conclusions Sequential administration of cytarabine and 213Bi-lintuzumab is tolerable and can produce remissions in patients with AML. PMID:20858843

  17. Energetic particle effects on global magnetohydrodynamic modes

    SciTech Connect

    Cheng, C.Z. (Princeton Plasma Physics Laboratory, Princeton University, Princeton, New Jersey 08543 (USA))

    1990-06-01

    The effects of energetic particles on magnetohydrodynamic (MHD) type modes are studied using analytical theories and the nonvariational kinetic-MHD stability code (NOVA-K) ({ital Workshop} {ital on} {ital Theory} {ital of} {ital Fusion} {ital Plasmas}, (Societa Italiana di Fisica, Bologna, 1987), p. 185). In particular, the problems of (1) the stabilization of ideal MHD internal kink modes and the excitation of resonant fishbone'' internal modes and (2) the alpha particle destabilization of toroidicity-induced Alfven eigenmodes (TAE) via transit resonances are addressed. Analytical theories are presented to help explain the NOVAresults. For energetic trapped particles generated by neutral beam injection or ion cyclotron resonant heating, a stability window for the {ital n}=1 internal kink mode in the hot particle beta space exists even in the absence of core ion finite Larmor radius effect. On the other hand, the trapped alpha particles are found to resonantly excite instability of the {ital n}=1 internal mode and can lower the critical beta threshold. The circulating alpha particles can strongly destabilize TAE modes via inverse Landau damping associated with the spatial gradient of the alpha-particle pressure.

  18. Energetic particle effects on global MHD modes

    SciTech Connect

    Cheng, C.Z.

    1990-01-01

    The effects of energetic particles on MHD type modes are studied by analytical theories and the nonvariational kinetic-MHD stability code (NOVA-K). In particular we address the problems of (1) the stabilization of ideal MHD internal kink modes and the excitation of resonant fishbone'' internal modes and (2) the alpha particle destabilization of toroidicity-induced Alfven eigenmodes (TAE) via transit resonances. Analytical theories are presented to help explain the NOVA-K results. For energetic trapped particles generated by neutral-beam injection (NBI) or ion cyclotron resonant heating (ICRH), a stability window for the n=1 internal kink mode in the hot particle beat space exists even in the absence of core ion finite Larmor radius effect (finite {omega}{sub *i}). On the other hand, the trapped alpha particles are found to resonantly excite instability of the n=1 internal mode and can lower the critical beta threshold. The circulating alpha particles can strongly destabilize TAE modes via inverse Landau damping associated with the spatial gradient of the alpha particle pressure. 23 refs., 5 figs.

  19. Particle acceleration efficiencies in astrophysical shear flows

    E-print Network

    F. M. Rieger; P. Duffy

    2005-02-04

    The acceleration of energetic particles in astrophysical shear flows is analyzed. We show that in the presence of a non-relativistic gradual velocity shear, power law particle momentum distributions $f(p) \\propto p^{-(3+\\alpha)}$ may be generated, assuming a momentum-dependent scattering time $\\tau \\propto p^{\\alpha}$, with $\\alpha > 0$. We consider possible acceleration sites in astrophysical jets and study the conditions for efficient acceleration. It is shown, for example, that in the presence of a gradual shear flow and a gyro-dependent particle mean free path, synchrotron radiation losses no longer stop the acceleration once it has started to work efficiently. This suggests that shear acceleration may naturally account for a second, non-thermal population of energetic particles in addition to a shock-accelerated one. The possible relevance of shear acceleration is briefly discussed with reference to the relativistic jet in the quasar 3C 273.

  20. Particle acceleration efficiencies in astrophysical shear flows

    E-print Network

    Rieger, F M

    2005-01-01

    The acceleration of energetic particles in astrophysical shear flows is analyzed. We show that in the presence of a non-relativistic gradual velocity shear, power law particle momentum distributions $f(p) \\propto p^{-(3+\\alpha)}$ may be generated, assuming a momentum-dependent scattering time $\\tau \\propto p^{\\alpha}$, with $\\alpha > 0$. We consider possible acceleration sites in astrophysical jets and study the conditions for efficient acceleration. It is shown, for example, that in the presence of a gradual shear flow and a gyro-dependent particle mean free path, synchrotron radiation losses no longer stop the acceleration once it has started to work efficiently. This suggests that shear acceleration may naturally account for a second, non-thermal population of energetic particles in addition to a shock-accelerated one. The possible relevance of shear acceleration is briefly discussed with reference to the relativistic jet in the quasar 3C 273.

  1. I. Excluded Volume Effects in Ising Cluster Distributions and Nuclear Multifragmentation II. Multiple-Chance Effects in Alpha-Particle Evaporation

    SciTech Connect

    Breus, Dimitry E.

    2005-05-16

    In Part 1, geometric clusters of the Ising model are studied as possible model clusters for nuclear multifragmentation. These clusters may not be considered as non-interacting (ideal gas) due to excluded volume effect which predominantly is the artifact of the cluster's finite size. Interaction significantly complicates the use of clusters in the analysis of thermodynamic systems. Stillinger's theory is used as a basis for the analysis, which within the RFL (Reiss, Frisch, Lebowitz) fluid-of-spheres approximation produces a prediction for cluster concentrations well obeyed by geometric clusters of the Ising model. If thermodynamic condition of phase coexistence is met, these concentrations can be incorporated into a differential equation procedure of moderate complexity to elucidate the liquid-vapor phase diagram of the system with cluster interaction included. The drawback of increased complexity is outweighted by the reward of greater accuracy of the phase diagram, as it is demonstrated by the Ising model. A novel nuclear-cluster analysis procedure is developed by modifying Fisher's model to contain cluster interaction and employing the differential equation procedure to obtain thermodynamic variables. With this procedure applied to geometric clusters, the guidelines are developed to look for excluded volume effect in nuclear multifragmentation. In part 2, an explanation is offered for the recently observed oscillations in the energy spectra of {alpha}-particles emitted from hot compound nuclei. Contrary to what was previously expected, the oscillations are assumed to be caused by the multiple-chance nature of {alpha}-evaporation. In a semi-empirical fashion this assumption is successfully confirmed by a technique of two-spectra decomposition which treats experimental {alpha}-spectra has having contributions from at least two independent emitters. Building upon the success of the multiple-chance explanation of the oscillations, Moretto's single-chance evaporation theory is augmented to include multiple-chance emission and tested on experimental data to yield positive results.

  2. Apparatus for measuring particle properties

    DOEpatents

    Rader, D.J.; Castaneda, J.N.; Grasser, T.W.; Brockmann, J.E.

    1998-08-11

    An apparatus is described for determining particle properties from detected light scattered by the particles. The apparatus uses a light beam with novel intensity characteristics to discriminate between particles that pass through the beam and those that pass through an edge of the beam. The apparatus can also discriminate between light scattered by one particle and light scattered by multiple particles. The particle`s size can be determined from the intensity of the light scattered. The particle`s velocity can be determined from the elapsed time between various intensities of the light scattered. 11 figs.

  3. Review of Particle Physics

    NASA Astrophysics Data System (ADS)

    Yao, W.-M.; Amsler, C.; Asner, D.; Barnett, R. M.; Beringer, J.; Burchat, P. R.; Carone, C. D.; Caso, C.; Dahl, O.; D'Ambrosio, G.; De Gouvea, A.; Doser, M.; Eidelman, S.; Feng, J. L.; Gherghetta, T.; Goodman, M.; Grab, C.; Groom, D. E.; Gurtu, A.; Hagiwara, K.; Hayes, K. G.; Hernández-Rey, J. J.; Hikasa, K.; Jawahery, H.; Kolda, C.; Kwon, Y.; Mangano, M. L.; Manohar, A. V.; Masoni, A.; Miquel, R.; Mönig, K.; Murayama, H.; Nakamura, K.; Navas, S.; Olive, K. A.; Pape, L.; Patrignani, C.; Piepke, A.; Punzi, G.; Raffelt, G.; Smith, J. G.; Tanabashi, M.; Terning, J.; Törnqvist, N. A.; sTrippe, T. G.; Vogel, P.; Watari, T.; Wohl, C. G.; Workman, R. L.; Zyla, P. A.; Armstrong, B.; Harper, G.; Lugovsky, V. S.; Schaffner, P.; Artuso, M.; Babu, K. S.; Band, H. R.; Barberio, E.; Battaglia, M.; Bichsel, H.; Biebel, O.; Bloch, P.; Blucher, E.; Cahn, R. N.; Casper, D.; Cattai, A.; Ceccucci, A.; Chakraborty, D.; Chivukula, R. S.; Cowan, G.; Damour, T.; DeGrand, T.; Desler, K.; Dobbs, M. A.; Drees, M.; Edwards, A.; Edwards, D. A.; Elvira, V. D.; Erler, J.; Ezhela, V. V.; Fetscher, W.; Fields, B. D.; Foster, B.; Froidevaux, D.; Gaisser, T. K.; Garren, L.; Gerber, H.-J.; Gerbier, G.; Gibbons, L.; Gilman, F. J.; Giudice, G. F.; Gritsan, A. V.; Grünewald, M.; Haber, H. E.; Hagmann, C.; Hinchliffe, I.; Höcker, A.; Igo-Kemenes, P.; JAckson, J. D.; Johnson, K. F.; Karlen, D.; Kayser, B.; Kirkby, D.; Klein, S. R.; Kleinknecht, K.; Knowles, I. G.; Kowalewski, R. V.; Kreitz, P.; Kursche, B.; Kuyanov, Yu. V.; Lahav, O.; Langacker, P.; Liddle, A.; Ligeti, Z.; Liss, T. M.; Littenberg, L.; Liu, J. C.; Lugovsky, K. S.; Lugovsky, s. B.; Mannel, T.; Manley, D. M.; Marciano, W. J.; Martin, A. D.; Milstead, D.; Narain, M.; Nason, P.; Nir, Y.; Peacock, J. A.; Prell, S. A.; Quadt, A.; Raby, S.; Ratcliff, B. N.; Razuvaev, E. A.; Renk, B.; Richardson, P.; Roesler, S.; Rolandi, G.; Ronan, M. T.; Rosenberg, L. J.; Sachrajda, C. T.; Sakai, Y.; Sarkar, S.; Schmitt, M.; Schneider, O.; Scott, D.; Sjöstrand, T.; Smoot, G. F.; Sokolsky, P.; Spanier, S.; Spieler, H.; Stahl, A.; Stanev, T.; Streitmatter, R. E.; Sumiyoshi, T.; Tkachenko, N. P.; Trilling, G. H.; Valencia, G.; van Bibber, K.; Vincter, M. G.; Ward, D. R.; Webber, B. R.; Wells, J. D.; Whalley, M.; Wolfenstsein, L.; Womersley, J.; Woody, C. L.; Yamamoto, A.; Zenin, O. V.; Zhang, J.; Zhu, R.-Y.

    2006-07-01

    This biennial Review summarizes much of particle physics. Using data from previous editions, plus 2633 new measurements from 689 papers, we list, evaluate, and average measured properties of gauge bosons, leptons, quarks, mesons, and baryons. We also summarize searches for hypothetical particles such as Higgs bosons, heavy neutrinos, and supersymmetric particles. All the particle properties and search limits are listed in Summary Tables. We also give numerous tables, figures, formulae, and reviews of topics such as the Standard Model, particle detectors, probability, and statistics. Among the 110 reviews are many that are new or heavily revised including those on CKM quark-mixing matrix, Vud & Vus, Vcb & Vub, top quark, muon anomalous magnetic moment, extra dimensions, particle detectors, cosmic background radiation, dark matter, cosmological parameters, and big bang cosmology. A booklet is available containing the Summary Tables and abbreviated versions of some of the other sections of this full Review. All tables, listings, and reviews (and errata) are also available on the Particle Data Group website: http://pdg.lbl.gov.

  4. Review of Particle Physics

    NASA Astrophysics Data System (ADS)

    Amsler, C.; Doser, M.; Antonelli, M.; Asner, D. M.; Babu, K. S.; Baer, H.; Band, H. R.; Barnett, R. M.; Bergren, E.; Beringer, J.; Bernardi, G.; Bertl, W.; Bichsel, H.; Biebel, O.; Bloch, P.; Blucher, E.; Blusk, S.; Cahn, R. N.; Carena, M.; Caso, C.; Ceccucci, A.; Chakraborty, D.; Chen, M.-C.; Chivukula, R. S.; Cowan, G.; Dahl, O.; D'Ambrosio, G.; Damour, T.; de Gouvêa, A.; DeGrand, T.; Dobrescu, B.; Drees, M.; Edwards, D. A.; Eidelman, S.; Elvira, V. D.; Erler, J.; Ezhela, V. V.; Feng, J. L.; Fetscher, W.; Fields, B. D.; Foster, B.; Gaisser, T. K.; Garren, L.; Gerber, H.-J.; Gerbier, G.; Gherghetta, T.; Giudice, G. F.; Goodman, M.; Grab, C.; Gritsan, A. V.; Grivaz, J.-F.; Groom, D. E.; Grünewald, M.; Gurtu, A.; Gutsche, T.; Haber, H. E.; Hagiwara, K.; Hagmann, C.; Hayes, K. G.; Hernández-Rey, J. J.; Hikasa, K.; Hinchliffe, I.; Höcker, A.; Huston, J.; Igo-Kemenes, P.; Jackson, J. D.; Johnson, K. F.; Junk, T.; Karlen, D.; Kayser, B.; Kirkby, D.; Klein, S. R.; Knowles, I. G.; Kolda, C.; Kowalewski, R. V.; Kreitz, P.; Krusche, B.; Kuyanov, Yu. V.; Kwon, Y.; Lahav, O.; Langacker, P.; Liddle, A.; Ligeti, Z.; Lin, C.-J.; Liss, T. M.; Littenberg, L.; Liu, J. C.; Lugovsky, K. S.; Lugovsky, S. B.; Mahlke, H.; Mangano, M. L.; Mannel, T.; Manohar, A. V.; Marciano, W. J.; Martin, A. D.; Masoni, A.; Milstead, D.; Miquel, R.; Mönig, K.; Murayama, H.; Nakamura, K.; Narain, M.; Nason, P.; Navas, S.; Nevski, P.; Nir, Y.; Olive, K. A.; Pape, L.; Patrignani, C.; Peacock, J. A.; Piepke, A.; Punzi, G.; Quadt, A.; Raby, S.; Raffelt, G.; Ratcliff, B. N.; Renk, B.; Richardson, P.; Roesler, S.; Rolli, S.; Romaniouk, A.; Rosenberg, L. J.; Rosner, J. L.; Sachrajda, C. T.; Sakai, Y.; Sarkar, S.; Sauli, F.; Schneider, O.; Scott, D.; Seligman, W. G.; Shaevitz, M. H.; Sjöstrand, T.; Smith, J. G.; Smoot, G. F.; Spanier, S.; Spieler, H.; Stahl, A.; Stanev, T.; Stone, S. L.; Sumiyoshi, T.; Tanabashi, M.; Terning, J.; Titov, M.; Tkachenko, N. P.; Törnqvist, N. A.; Tovey, D.; Trilling, G. H.; Trippe, T. G.; Valencia, G.; van Bibber, K.; Vincter, M. G.; Vogel, P.; Ward, D. R.; Watari, T.; Webber, B. R.; Weiglein, G.; Wells, J. D.; Whalley, M.; Wheeler, A.; Wohl, C. G.; Wolfenstein, L.; Womersley, J.; Woody, C. L.; Workman, R. L.; Yamamoto, A.; Yao, W.-M.; Zenin, O. V.; Zhang, J.; Zhu, R.-Y.; Zyla, P. A.; Harper, G.; Lugovsky, V. S.; Schaffner, P.; Particle Data Group

    2008-09-01

    This biennial Review summarizes much of particle physics. Using data from previous editions, plus 2778 new measurements from 645 papers, we list, evaluate, and average measured properties of gauge bosons, leptons, quarks, mesons, and baryons. We also summarize searches for hypothetical particles such as Higgs bosons, heavy neutrinos, and supersymmetric particles. All the particle properties and search limits are listed in Summary Tables. We also give numerous tables, figures, formulae, and reviews of topics such as the Standard Model, particle detectors, probability, and statistics. Among the 108 reviews are many that are new or heavily revised including those on CKM quark-mixing matrix, V ud & V us, V cb & V ub, top quark, muon anomalous magnetic moment, extra dimensions, particle detectors, cosmic background radiation, dark matter, cosmological parameters, and big bang cosmology. A booklet is available containing the Summary Tables and abbreviated versions of some of the other sections of this full Review. All tables, listings, and reviews (and errata) are also available on the Particle Data Group website: http://pdg.lbl.gov.

  5. The Particle Adventure

    NSDL National Science Digital Library

    This interactive presentation introduces users to particle physics. There is a discussion of the history of the study of what matter is made of, the current way scientists visualize the atom, and the size of the atom. It also describes the search for the 'fundamental' particle and the development of the Standard Model, which explains what the world is and what holds it together. There are also brief descriptions of some of the more exotic particles (quarks, leptons, neutrinos, hadryons, mesons, baryons and others). The presentation includes a brief introduction to the concepts of generations of matter, the four fundamental interactions between particles, and the forces that hold particles together, as well as how scientists study these particles, how they have reached their conclusions, and some of the unsolved mysteries of particle physics. Other materials include a variety of media (books, CD ROMs, posters, charts), a set of classroom actvities, a glossary, and links to related sites. The site is available in a number of languages, including French and Spanish.

  6. Test of statistical model predictions for alpha-particle decay of 90,92,94,96Ru compound nuclei

    Microsoft Academic Search

    B. Fornal; F. Gramegna; G. Prete; G. Nebbia; R. Smith; G. D'erasmo; L. Fiore; A. Pantaleo; G. Viesti; P. Blasi; F. Lucarelli; I. Iori; A. Moroni

    1990-01-01

    The alpha decay of Ru compound nuclei populated in 32S on 58,60,62,64Ni reactions at Ebeam=135-185 MeV has been studied. Experimental data have been compared with statistical model calculations performed with two different computer codes. The quality of the agreement between calculations and experimental data was found, in one case, to depend on the compound nucleus populated. Comparing the results from

  7. Measurement of the OXYGEN-17(PROTON, Alpha Particle) Nitrogen -14 Cross Section at Stellar Energies (proton Energies, Resonant Reaction)

    NASA Astrophysics Data System (ADS)

    Blackmon, Jeffery Curtis

    The isotopic abundance ratio 16O/17O has been shown to be a good probe of mass flow and mixing in stars. This ratio is sensitive to the depth of convective mixing which occurs on the giant branch and to the amount of nonconvective mixing occurring on the main sequence. The interpretation of recent observations of this ratio in red giants is limited by a large uncertainty in the value of the 17O(p, alpha)14N reaction rate. This reaction rate is dominated at stellar energies by a resonance at E_{rm x} = 5673 keV in the compound nucleus 18 F, whose strength was previously uncertain. We have carried out a measurement of the ^ {17}O(p,alpha)^{14 }N cross section at proton energies of 75 keV and 65 keV. Thick, high-purity rm Ta_2O _5 targets enriched to 77% ^ {17}O were used in conjunction with beam currents of 0.45 mA and large-solid-angle detectors. The background for the experiment was measured using targets of natural isotopic composition. The resonance peak was observed in the data collected at 75 keV, and we determined the proton width of the 5673 keV state to be 22 +/- 4 neV. This implies a rate for the 17O(p,alpha)^ {14}N reaction that is ten times greater than the typical rates used previously in stellar models.

  8. Soil Particle Density Protocol

    NSDL National Science Digital Library

    The GLOBE Program, University Corporation for Atmospheric Research (UCAR)

    2003-08-01

    The purpose of this resource is to measure the soil particle density of each horizon in a soil profile. Students weigh a sample of dry, sieved soil from a horizon, mix it with distilled water and then boil the mixture to remove any air. The mixture cools for a day and then students add water until the volume of the mixture is 100 mL. Students measure the temperature and mass of the final mixture and use the Soil Particle Density Data Sheet to calculate the soil particle density. Three samples should be measured for each horizon.

  9. Fermilab: Particle Physics

    NSDL National Science Digital Library

    This Fermilab website offers physicists the chance to educate individuals about the "fundamental particles and forces of our universe." The website offers a database containing over 250 hands-on activities, special events, research participation, and other educational and outreach programs. The information can be searched by state, audience, and institution. The database offers a brief description of each program and a link to its website. Students can learn about the basics of particle physics through a concise article. Educators can discover why particle physics education is important.

  10. Charged particle accelerator grating

    DOEpatents

    Palmer, Robert B. (Shoreham, NY)

    1986-01-01

    A readily disposable and replaceable accelerator grating for a relativistic particle accelerator. The grating is formed for a plurality of liquid droplets that are directed in precisely positioned jet streams to periodically dispose rows of droplets along the borders of a predetermined particle beam path. A plurality of lasers are used to direct laser beams into the droplets, at predetermined angles, thereby to excite the droplets to support electromagnetic accelerating resonances on their surfaces. Those resonances operate to accelerate and focus particles moving along the beam path. As the droplets are distorted or destroyed by the incoming radiation, they are replaced at a predetermined frequency by other droplets supplied through the jet streams.

  11. Entanglement of Accelerating Particles

    E-print Network

    W. L. Ku; M. -C. Chu

    2007-09-03

    We study how the entanglement of a maximally entangled pair of particles is affected when one or both of the pair are uniformly accelerated, while the detector remains in an inertial frame. We find that the entanglement is unchanged if all degrees of freedom are considered. However, particle pairs are produced, and the entanglements of different bipartite systems may change with the acceleration. In particular, the entanglement between accelerating fermions is transferred preferentially to the produced antiparticles when the acceleration is large, and the entanglement transfer is complete when the acceleration approaches infinity. However, for scalar particles, no entanglement transfer to the antiparticles is observed.

  12. Big Bang Day: 5 Particles - 5. The Next Particle

    SciTech Connect

    None

    2009-10-08

    Simon Singh looks at the stories behind the discovery of 5 of the universe's most significant subatomic particles: the Electron, the Quark, the Anti-particle, the Neutrino and the "next particle". 5. The Next Particle The "sparticle" - a super symmetric partner to all the known particles could be the answer to uniting all the known particles and their interactions under one grand theoretical pattern of activity. But how do researchers know where to look for such phenomena and how do they know if they find them? Simon Singh reviews the next particle that physicists would like to find if the current particle theories are to ring true.

  13. The Alpha Particle X-Ray Spectrometer APXS on the Rosetta lander Philae to explore the surface of comet 67P/Churyumov-Gerasimenko

    NASA Astrophysics Data System (ADS)

    Klingelhoefer, Goestar; Girones Lopez, Jordi; Schmanke, Dirk; Markovski, Cristina; Brückner, Johannes; d'Uston, Claude; Economu, Tom; Gellert, Ralf

    2015-04-01

    The Rosetta Mission was launched in 2004 with the main objectives to gain a better understanding of the origin and formation of comets and the solar system. After 10 years of cruise Rosetta rendevouded with the comet 67P/Churyumov-Gerasimenko in 2014 to study the nucleus of the comet and its environment. Rosetta consists of an orbiter and a lander (Philae) with 11 and 9 scientific experiments respectively. It did what has never been attempted before, orbiting and landing on a comet. After orbit insertion in August 2014, the main spacecraft will follow the comet for several months to investigate its surface. Subsequently, Philae has been deployed for a safe landing. As part of the lander payload the APXS will measure in situ the chemical composition of the comet's surface and it's changes during the journey of the comet around the sun. The data obtained with the APXS will be used to characterize the surface of the comet, to determine the chemical composition of the dust component, and to compare the dust with known meteorite types. APXS combines an alpha mode for alpha backscattering spectroscopy and an x-ray mode for alpha particle/x-ray induced x-ray spectroscopy (XRF) in one single instrument, being low in mass (640g) and power consumption (1.5 W in operating mode) [4]. The comet surface will be irradiated by a Curium 244 source exciting characteristic x-rays of the elements present in the surface material. The alpha mode will allow detection of elements like C and O and groups of elements with a higher Z. The x-ray-SD-detector will allow the detection of most of the elements from Na up to Ni and above. The design of the Rosetta APX spectrometer is based on the experience gained with the APXS built for Russian and American Mars missions: Mars 96 spacecraft and Mars Pathfinder, MPF [1]. Two APXS were also built for the Mars Exploration Rovers mission of the NASA, MER [2-3]. Acknowledgements This project is funded by the German Space Agency DLR under contracts 50 QP 0404 and 50 QP 0902 and the Max Planck Society. References: [1] Brückner, J., Dreibus, G., Rieder, R., and Wänke, H.: 2003, J. Geophys. Res. 108(E12), 8094. [2] Gellert, R., et al.: 2006, J. Geophys. Res. - Planets 111, E02S05. [3] Klingelhöfer, G., Brückner, J., D'uston, C., Gellert, R. und Rieder, R.: 2007, Space Science Reviews 383, 128.

  14. Volumetric particle modeling 

    E-print Network

    Dingle, Brent Michael

    2007-09-17

    This dissertation presents a robust method of modeling objects and forces for computer animation. Within this method objects and forces are represented as particles. As in most modeling systems, the movement of objects is driven by physically based...

  15. Review of Particle Physics

    E-print Network

    Nakamura, Kenzo

    2010-01-01

    and ?(f f ) are the electron and fermion partial widths ofhanded incident electron to produce a fermion f traveling infermions, are their own antiparticles. An electrically charged particle (like the electron)

  16. Particle Physics Masterclass

    ScienceCinema

    Helio Takai

    2010-01-08

    Students from six local high schools -- Farmingdale, Sachem East, Shoreham, Smithtown East, Ward Melville, and William Floyd -- came to Brookhaven National Laboratory to experience research with particle physicist Helio Takai. They were among more than 6,

  17. Particle Size Analysis.

    ERIC Educational Resources Information Center

    Barth, Howard G.; Sun, Shao-Tang

    1989-01-01

    Presents a review of research focusing on scattering, elution techniques, electrozone sensing, filtration, centrifugation, comparison of techniques, data analysis, and particle size standards. The review covers the period 1986-1988. (MVL)

  18. Particles in complex fluids 

    E-print Network

    Zand, Daniëlle D. van ’t

    2010-01-01

    This thesis describes experimental studies of colloidal particles dispersed in solvents which themselves have phase transitions. One common definition of soft matter is: a material characterized by a mesoscopic length ...

  19. m anchester particle physics

    E-print Network

    and identification of charged pions, kaons, protons and leptons. They are each composed of a high precision silicon. tracking volume and refined calorimetry, complements these experiments by specialising in neutral particle

  20. Magnetic Particle Imaging

    SciTech Connect

    Minard, Kevin R.

    2010-02-01

    Rapid advances in the synthesis of superparamagnetic nanoparticles has stimulated widespread interest in their use as contrast agents for visualizing biological processes with Magnetic Resonance Imaging (MRI). With this approach, strong particle magnetism alters the MRI signal from nearby water protons and this, in turn, affects observed image contrast. Magnetic particle detection with MRI is therefore indirect and suffers from several associated problems, including poor quantification and tissuedependent performance. Magnetic Particle Imaging (MPI) overcomes these by directly measuring the amount of superparamagnetic material at each location. Mass sensitivity, spatial resolution, and imaging time is also comparable to or better than that achieved with MRI. Moreover, MPI is relatively inexpensive, meets all current safety guidelines, is quantitative, provides unambiguous contrast with tissue-independent performance, and can detect lower particle concentrations. Here, the basic principles behind MPI are described, factors affecting sensitivity and resolution are discussed, and potential utility for biomedical use is examined.

  1. Particle Engulfment and Pushing

    NASA Technical Reports Server (NTRS)

    2001-01-01

    As a liquefied metal solidifies, particles dispersed in the liquid are either pushed ahead of or engulfed by the moving solidification front. Similar effects can be seen when the ground freezes and pushes large particles out of the soil. The Particle Engulfment and Pushing (PEP) experiment, conducted aboard the fourth U.S. Microgravity Payload (USMP-4) mission in 1997, used a glass and plastic beads suspended in a transparent liquid. The liquid was then frozen, trapping or pushing the particles as the solidifying front moved. This simulated the formation of advanced alloys and composite materials. Such studies help scientists to understand how to improve the processes for making advanced materials on Earth. The principal investigator is Dr. Doru Stefanescu of the University of Alabama. This image is from a video downlink.

  2. Accelerating Particles with Plasma

    SciTech Connect

    Litos, Michael; Hogan, Mark

    2014-11-05

    Researchers at SLAC explain how they use plasma wakefields to accelerate bunches of electrons to very high energies over only a short distance. Their experiments offer a possible path for the future of particle accelerators.

  3. Ultra High Energy Particles

    E-print Network

    Burra G. Sidharth

    2011-07-22

    We revisit considerations of temporal order in relativistic effects, taking into account Heisenberg's Uncertainty Principle. We then use a formulation of relativistic Quantum Mechanical equations given by Feshbach and Villars to exhibit novel particle antiparticle effects.

  4. Particle separation by dielectrophoresis

    PubMed Central

    Gascoyne, Peter R. C.; Vykoukal, Jody

    2009-01-01

    The application of dielectrophoresis to particle discrimination, separation, and fractionation is reviewed, some advantages and disadvantages of currently available approaches are considered, and some caveats are noted. PMID:12210248

  5. Particle Accelerators Test Cosmological Theory.

    ERIC Educational Resources Information Center

    Schramm, David N.; Steigman, Gary

    1988-01-01

    Discusses the symbiotic relationship of cosmology and elementary-particle physics. Presents a brief overview of particle physics. Explains how cosmological considerations set limits on the number of types of elementary particles. (RT)

  6. Alpha particle and proton relative thermoluminescence efficiencies in LiF:Mg,Cu,P:is track structure theory up to the task?

    PubMed

    Horowitz, Y S; Siboni, D; Oster, L; Livingstone, J; Guatelli, S; Rosenfeld, A; Emfietzoglou, D; Bilski, P; Obryk, B

    2012-07-01

    Low-energy alpha particle and proton heavy charged particle (HCP) relative thermoluminescence (TL) efficiencies are calculated for the major dosimetric glow peak in LiF:Mg,Cu,P (MCP-N) in the framework of track structure theory (TST). The calculations employ previously published TRIPOS-E Monte Carlo track segment values of the radial dose in condensed phase LiF calculated at the Instituto National de Investigaciones Nucleares (Mexico) and experimentally measured normalised (60)Co gamma-induced TL dose-response functions, f(D), carried out at the Institute of Nuclear Physics (Poland). The motivation for the calculations is to test the validity of TST in a TL system in which f(D) is not supralinear (f(D) >1) and is not significantly dependent on photon energy contrary to the behaviour of the dose-response of composite peak 5 in the glow curve of LiF:Mg,Ti (TLD-100). The calculated HCP relative efficiencies in LiF:MCP-N are 23-87% lower than the experimentally measured values, indicating a weakness in the major premise of TST which exclusively relates HCP effects to the radiation action of the secondary electrons liberated by the HCP slowing down. However, an analysis of the uncertainties involved in the TST calculations and experiments (i.e. experimental measurement of f(D) at high levels of dose, sample light self-absorption and accuracy in the estimation of D(r), especially towards the end of the HCP track) indicate that these may be too large to enable a definite conclusion. More accurate estimation of sample light self-absorption, improved measurements of f(D) and full-track Monte Carlo calculations of D(r) incorporating improvements of the low-energy electron transport are indicated in order to reduce uncertainties and enable a final conclusion. PMID:22042968

  7. Dark matter particles

    E-print Network

    V. Berezinsky

    1996-10-31

    The baryonic and cold dark matter are reviewed in the context of cosmological models. The theoretical search for the particle candidates is limited by supersymmetric extension of the Standard Model. Generically in such models there are just two candidates associated with each other: generalized neutralino, which components are usual neutralino and axino, and axion which is a partner of axino in supermultiplet. The status of these particles as DM candidates is described.

  8. Particle swarm optimization

    Microsoft Academic Search

    Riccardo Poli; James Kennedy; Tim Blackwell

    2007-01-01

    Particle swarm optimization (PSO) has undergone many changes since its introduction in 1995. As researchers have learned about\\u000a the technique, they have derived new versions, developed new applications, and published theoretical studies of the effects\\u000a of the various parameters and aspects of the algorithm. This paper comprises a snapshot of particle swarming from the authors’\\u000a perspective, including variations in the

  9. Safe biodegradable fluorescent particles

    DOEpatents

    Martin, Sue I. (Berkeley, CA); Fergenson, David P. (Alamo, CA); Srivastava, Abneesh (Santa Clara, CA); Bogan, Michael J. (Dublin, CA); Riot, Vincent J. (Oakland, CA); Frank, Matthias (Oakland, CA)

    2010-08-24

    A human-safe fluorescence particle that can be used for fluorescence detection instruments or act as a safe simulant for mimicking the fluorescence properties of microorganisms. The particle comprises a non-biological carrier and natural fluorophores encapsulated in the non-biological carrier. By doping biodegradable-polymer drug delivery microspheres with natural or synthetic fluorophores, the desired fluorescence can be attained or biological organisms can be simulated without the associated risks and logistical difficulties of live microorganisms.

  10. Volumetric particle modeling

    E-print Network

    Dingle, Brent Michael

    2007-09-17

    Packings of unit spheres for side length, s, of 4.05, 8.95, and 5.40 units....................... 42 14 A demonstration of grouping internal particles ............................................................. 45 15 A particle in a basic grid... here can be used to create volumetric objects directly from scanned density data or from reasonable assumptions about the internal structure of surface scanned data. Specifically, with regard to scanning methods where the density values of the scanned...

  11. The Least Particle Theory

    NASA Astrophysics Data System (ADS)

    Hartsock, Robert

    2011-10-01

    The Least Particle Theory states that the universe was cast as a great sea of energy. MaX Planck declared a quantum of energy to be the least value in the universe. We declare the quantum of energy to be the least particle in the universe. Stephen Hawking declared quantum mechanics to be of no value in todays gross mechanics. That's like saying the number 1 has no place in mathematics.

  12. ELEMENTARY PARTICLE INTERACTIONS

    SciTech Connect

    EFREMENKO, YURI; HANDLER, THOMAS; KAMYSHKOV, YURI; SIOPSIS, GEORGE; SPANIER, STEFAN

    2013-07-30

    The High-Energy Elementary Particle Interactions group at UT during the last three years worked on the following directions and projects: Collider-based Particle Physics; Neutrino Physics, particularly participation in “NO?A”, “Double Chooz”, and “KamLAND” neutrino experiments; and Theory, including Scattering amplitudes, Quark-gluon plasma; Holographic cosmology; Holographic superconductors; Charge density waves; Striped superconductors; and Holographic FFLO states.

  13. PARTICLES OF DIFFERENCE.

    SciTech Connect

    SCHWARTZ,S.E.

    2000-09-21

    It is no longer appropriate, if it ever was, to think of atmospheric aerosols as homogeneous spheres of uniform composition and size. Within the United States, and even more globally, not only the mass loading but also the composition, morphology, and size distribution of atmospheric aerosols are highly variable, as a function of location, and at a given location as a function of time. Particles of a given aerodynamic size may differ from one another, and even within individual particles material may be inhomogeneously distributed, as for example, carbon spherules imbedded in much larger sulfate particles. Some of the particulate matter is primary, that is, introduced into the atmosphere directly as particles, such as carbon particles in diesel exhaust. Some is secondary, that is, formed in the atmosphere by gas-to-particle conversion. Much of the material is inorganic, mainly sulfates and nitrates resulting mainly from energy-related emissions. Some of the material is carbonaceous, in part primary, in part secondary, and of this material some is anthropogenic and some biogenic. While the heterogeneity of atmospheric aerosols complicates the problem of understanding their loading and distribution, it may well be the key to its solution. By detailed examination of the materials comprising aerosols it is possible to infer the sources of these materials. It may be possible as well to identify specific health impairing agents. The heterogeneity of aerosol particles is thus the key to identifying their sources, to understanding the processes that govern their loading and properties, and to devising control strategies that are both effective and efficient. Future research must therefore take cognizance of differences among aerosol particles and use these differences to advantage.

  14. On Characterizing Particle Shape

    NASA Technical Reports Server (NTRS)

    Ennis, Bryan J.; Rickman, Douglas; Rollins, A. Brent; Ennis, Brandon

    2014-01-01

    It is well known that particle shape affects flow characteristics of granular materials, as well as a variety of other solids processing issues such as compaction, rheology, filtration and other two-phase flow problems. The impact of shape crosses many diverse and commercially important applications, including pharmaceuticals, civil engineering, metallurgy, health, and food processing. Two applications studied here include the dry solids flow of lunar simulants (e.g. JSC-1, NU-LHT-2M, OB-1), and the flow properties of wet concrete, including final compressive strength. A multi-dimensional generalized, engineering method to quantitatively characterize particle shapes has been developed, applicable to both single particle orientation and multi-particle assemblies. The two-dimension, three dimension inversion problem is also treated, and the application of these methods to DEM model particles will be discussed. In the case of lunar simulants, flow properties of six lunar simulants have been measured, and the impact of particle shape on flowability - as characterized by the shape method developed here -- is discussed, especially in the context of three simulants of similar size range. In the context of concrete processing, concrete construction is a major contributor to greenhouse gas production, of which the major contributor is cement binding loading. Any optimization in concrete rheology and packing that can reduce cement loading and improve strength loading can also reduce currently required construction safety factors. The characterization approach here is also demonstrated for the impact of rock aggregate shape on concrete slump rheology and dry compressive strength.

  15. System for forming janus particles

    DOEpatents

    Hong, Liang (Midland, MI); Jiang, Shan (Champaign, IL); Granick, Steve (Champaign, IL)

    2011-01-25

    The invention is a method of forming Janus particles, that includes forming an emulsion that contains initial particles, a first liquid, and a second liquid; solidifying the first liquid to form a solid that contains at least a portion of the initial particles on a surface of the solid; and treating the exposed particle sides with a first surface modifying agent, to form the Janus particles. Each of the initial particles on the surface has an exposed particle side and a blocked particle side.

  16. Macroscopic Quantum State Analyzed Particle by Particle

    NASA Astrophysics Data System (ADS)

    Beduini, Federica A.; Zieli?ska, Joanna A.; Lucivero, Vito G.; de Icaza Astiz, Yannick A.; Mitchell, Morgan W.

    2015-03-01

    Macroscopic quantum phenomena, e.g., superconductivity and squeezing, are believed to result from entanglement of macroscopic numbers of particles. We report the first direct study of this kind of entanglement: we use discrete quantum tomography to reconstruct the joint quantum state of photon pairs extracted from polarization-squeezed light. Our observations confirm several predictions from spin-squeezing theory [Beduini et al., Phys. Rev. Lett. 111, 143601 (2013)], including strong entanglement and entanglement of all photon pairs within the squeezing coherence time. This photon-by-photon analysis may give insight into other macroscopic many-body systems, e.g., photon Bose-Einstein condensates.

  17. Measurement of the track etch rates along proton and alpha particle trajectories in CR39 and calculation of the detection efficiency

    Microsoft Academic Search

    B. Dörschel; R. Bretschneider; D. Hermsdorf; K. Kadner; H. Kühne

    1999-01-01

    Computation of the neutron response of CR-39 detectors needs to simulate the track formation by neutron induced charged particles taking into account the bulk etch rate and the track etch rate varying along the particle trajectories. The latter one was determined experimentally by track length measurement. The results allowed to derive the relationship between the track etch rate and the

  18. First In Vivo Evaluation of Liposome-encapsulated 223Ra as a Potential Alpha-particle-emitting Cancer Therapeutic Agent

    SciTech Connect

    Jonasdottir, Thora J.; Fisher, Darrell R.; Borrebaek, Jorgen; Bruland, Oyvind S.; Larsen, Roy H.

    2006-09-13

    Liposomes carrying chemotherapeutics have had some success in cancer treatment and may be suitable carriers for therapeutic radionuclides. This study was designed to evaluate the biodistribution of and to estimate the radiation doses from the alpha emitter 223Ra loaded into pegylated liposomes in selected tissues. 223Ra was encapsulated in pegylated liposomal doxorubicin by ionophore-mediated loading. The biodistribution of liposomal 223Ra was compared to free cationic 223Ra in Balb/C mice. We showed that liposomal 223 Ra circulated in the blood with an initial half-time in excess of 24 hours, which agreed well with that reported for liposomal doxorubicin in rodents, while the blood half-time of cationic 223Ra was considerably less than one hour. When liposomal 223 Ra was catabolized, the released 223Ra was either excreted or taken up in the skeleton. This skeletal uptake increased up to 14 days after treatment, but did not reach the level seen with free 223Ra. Pre-treatment with non-radioactive liposomal doxorubicin 4 days in advance lessened the liver uptake of liposomal 223 Ra. Dose estimates showed that the spleen, followed by bone surfaces, received the highest absorbed doses. Liposomal 223 Ra was relatively stable in vivo and may have potential for radionuclide therapy and combination therapy with chemotherapeutic agents.

  19. Particle-Charge Spectrometer

    NASA Technical Reports Server (NTRS)

    Fuerstenau, Stephen; Wilson, Gregory R.

    2008-01-01

    An instrument for rapidly measuring the electric charges and sizes (from approximately 1 to approximately 100 micrometers) of airborne particles is undergoing development. Conceived for monitoring atmospheric dust particles on Mars, instruments like this one could also be used on Earth to monitor natural and artificial aerosols in diverse indoor and outdoor settings for example, volcanic regions, clean rooms, powder-processing machinery, and spray-coating facilities. The instrument incorporates a commercially available, low-noise, ultrasensitive charge-sensing preamplifier circuit. The input terminal of this circuit--the gate of a field-effect transistor--is connected to a Faraday-cage cylindrical electrode. The charged particles of interest are suspended in air or other suitable gas that is made to flow along the axis of the cylindrical electrode without touching the electrode. The flow can be channeled and generated by any of several alternative means; in the prototype of this instrument, the gas is drawn along a glass capillary tube (see upper part of figure) coaxial with the electrode. The size of a particle affects its rate of acceleration in the flow and thus affects the timing and shape of the corresponding signal peak generated by the charge-sensing amplifier. The charge affects the magnitude (and thus also the shape) of the signal peak. Thus, the signal peak (see figure) conveys information on both the size and electric charge of a sensed particle. In experiments thus far, the instrument has been found to be capable of measuring individual aerosol particle charges of magnitude greater than 350 e (where e is the fundamental unit of electric charge) with a precision of +/- 150 e. The instrument can sample particles at a rate as high as several thousand per second.

  20. Particles causing lung disease.

    PubMed Central

    Kilburn, K H

    1984-01-01

    The lung has a limited number of patterns of reaction to inhaled particles. The disease observed depends upon the location: conducting airways, terminal bronchioles and alveoli, and upon the nature of inflammation induced: acute, subacute or chronic. Many different agents cause narrowing of conducting airways (asthma) and some of these cause permanent distortion or obliteration of airways as well. Terminal bronchioles appear to be particularly susceptible to particles which cause goblet cell metaplasia, mucous plugging and ultimately peribronchiolar fibrosis. Cancer is the last outcome at the bronchial level and appears to depend upon continuous exposure to or retention of an agent in the airway and failure of the affected cells to be exfoliated which may be due to squamous metaplasia. Alveoli are populated by endothelial cells, Type I or pavement epithelial cells and metabolically active cuboidal Type II cells that produce the lungs specific surfactant, dipalmytol lecithin. Disturbances of surfactant lead to edema in distal lung while laryngeal edema due to anaphylaxis or fumes may produce asphyxia. Physical retention of indigestible particles or retention by immune memory responses may provoke hyaline membranes, stimulate alveolar lipoproteinosis and finally fibrosis. This later exuberant deposition of connective tissue has been best studied in the occupational pneumoconioses especially silicosis and asbestosis. In contrast emphysema a catabolic response, appears frequently to result from leakage or release of lysosomal proteases into the lung during processing of cigarette smoke particles. The insidious and probably most important human lung disease due to particles is bronchiolar obstruction and obliteration, producing progressive impairment of air flow. The responsible particle is the complex combination of poorly digestive lipids and complex carbohydrates with active chemicals which we call cigarette smoke. More research is needed to perfect, correct and quantify our preliminary picture of the pathogenesis of lung disease by particles, but a useful start has been made. Images FIGURE 1. PMID:6376114

  1. Trapped particle destabilization of the internal kink mode

    SciTech Connect

    White, R.B.; Chen, L.; Romanelli, F.; Hay, R.

    1984-06-01

    The internal kink mode is destabilized by trapped high energy particles, leading to a new branch of the internal kink dispersion relation with a real frequency near the average trapped particle precession frequency and a growth rate of the same magnitude. This trapped particle branch of the dispersion relation is investigated numerically for a variety of particle distributions. Mode growth rate and frequency are found as a function of plasma ..beta.., density, and trapped particle energy and distribution. The high energy trapped particle sources considered are neutral beam injection, ion cyclotron heating, and fusion alpha particles. Relevance for various plasma heating schemes is discussed.

  2. Evaluation of alpha-fetoprotein (AFP) in human serum by chemiluminescence enzyme immunoassay with magnetic particles and coated tubes as solid phases.

    PubMed

    Zhang, Qianyun; Wang, Xu; Li, Zhenjia; Lin, Jin-Ming

    2009-01-12

    In this work, the monoclonal antibodies (McAbs) to alpha-fetoprotein (AFP) were immobilized on two different solid phases, i.e., magnetic particles (MP) and coated tubes (CT). Based on this, a MP based chemiluminescence enzyme immunoassay (MP-CLEIA) and a CT based CLEIA (CT-CLEIA) were proposed for the evaluation of AFP in human serum and their analytical merits were studied and compared. By detailed discussion of several performance variants, including the concentration of immobilized McAb, dilution ratio of horseradish peroxidase (HRP) labeled McAb (HRP-McAb), total assay time, substrate volume, chemiluminescent kinetics, and hook effect concentration, the advantages of MP-CLEIA became conspicuously apparent. Moreover, in the presence of MP, the catalytic activity of labeled enzyme was kept to high extent and the stability of immunoreagents was satisfied. Finally, 59 human serum samples were detected by the MP-CLEIA and a good correlation was obtained when comparing the results with that from a commercial electrochemiluminescence immunoassay kit. PMID:19084628

  3. Geochemical properties of rocks and soils in Gusev Crater, Mars: Results of the Alpha Particle X-Ray Spectrometer from Cumberland Ridge to Home Plate

    NASA Astrophysics Data System (ADS)

    Ming, D. W.; Gellert, R.; Morris, R. V.; Arvidson, R. E.; Brückner, J.; Clark, B. C.; Cohen, B. A.; d'Uston, C.; Economou, T.; Fleischer, I.; Klingelhöfer, G.; McCoy, T. J.; Mittlefehldt, D. W.; Schmidt, M. E.; Schröder, C.; Squyres, S. W.; Tréguier, E.; Yen, A. S.; Zipfel, J.

    2008-12-01

    Geochemical diversity of rocks and soils has been discovered by the Alpha Particle X-Ray Spectrometer (APXS) during Spirit's journey over Husband Hill and down into the Inner Basin from sol 470 to 1368. The APXS continues to operate nominally with no changes in calibration or spectral degradation over the course of the mission. Germanium has been added to the Spirit APXS data set with the confirmation that it occurs at elevated levels in many rocks and soils around Home Plate. Twelve new rock classes and two new soil classes have been identified at the Spirit landing site since sol 470 on the basis of the diversity in APXS geochemistry. The new rock classes are Irvine (alkaline basalt), Independence (low Fe outcrop), Descartes (outcrop similar to Independence with higher Fe and Mn), Algonquin (mafic-ultramafic igneous sequence), Barnhill (volcaniclastic sediments enriched in Zn, Cl, and Ge), Fuzzy Smith (high Si and Ti rock), Elizabeth Mahon (high Si, Ni, and Zn outcrop and rock), Halley (hematite-rich outcrop and rock), Montalva (high K, hematite-rich rock), Everett (high Mg, magnetite-rich rock), Good Question (high Si, low Mn rock), and Torquas (high K, Zn, and Ni magnetite-rich rock). New soil classes are Gertrude Weise (very high Si soil) and Eileen Dean (high Mg, magnetite-rich soil). Aqueous processes have played a major role in the formation and alteration of rocks and soils on Husband Hill and in the Inner Basin.

  4. Particle composition measurements during CLOUD7

    NASA Astrophysics Data System (ADS)

    Lawler, Michael; Smith, James; Winkler, Paul; Cloud Collaboration

    2013-05-01

    The chemical composition of >8 nm diameter aerosol was measured using the Timeof-Flight Thermal Desorption Chemical Ionization Mass Spectrometer (TOF-TDCIMS) during CLOUD7 particle nucleation experiments in Fall 2012 at the CLOUD chamber at CERN in Geneva, Switzerland. Sulfate dominated the negative ion particle spectra during all events with enough particle mass to observe, both in experiments with amine and alpha-pinene. Ammonium was also a major particle constituent during all observable events, though gaseous ammonia was present in the chamber only as a contaminant. During nucleation events following the oxidation of alpha-pinene, highly oxidized organic acids such as oxalic and oxoacetic acid were observed to be significant components of the collected aerosol.

  5. Big Bang Day: 5 Particles - 3. The Anti-particle

    SciTech Connect

    None

    2009-10-07

    Simon Singh looks at the stories behind the discovery of 5 of the universe's most significant subatomic particles: the Electron, the Quark, the Anti-particle, the Neutrino and the "next particle". 3. The Anti-particle. It appears to be the stuff of science fiction. Associated with every elementary particle is an antiparticle which has the same mass and opposite charge. Should the two meet and combine, the result is annihilation - and a flash of light. Thanks to mysterious processes that occurred after the Big Bang there are a vastly greater number of particles than anti-particles. So how could their elusive existence be proved? At CERN particle physicists are crashing together subatomic particles at incredibly high speeds to create antimatter, which they hope will finally reveal what happened at the precise moment of the Big Bang to create the repertoire of elementary particles and antiparticles in existence today.

  6. Big Bang Day: 5 Particles - 3. The Anti-particle

    ScienceCinema

    None

    2011-04-25

    Simon Singh looks at the stories behind the discovery of 5 of the universe's most significant subatomic particles: the Electron, the Quark, the Anti-particle, the Neutrino and the "next particle". 3. The Anti-particle. It appears to be the stuff of science fiction. Associated with every elementary particle is an antiparticle which has the same mass and opposite charge. Should the two meet and combine, the result is annihilation - and a flash of light. Thanks to mysterious processes that occurred after the Big Bang there are a vastly greater number of particles than anti-particles. So how could their elusive existence be proved? At CERN particle physicists are crashing together subatomic particles at incredibly high speeds to create antimatter, which they hope will finally reveal what happened at the precise moment of the Big Bang to create the repertoire of elementary particles and antiparticles in existence today.

  7. Gravitational radiation in massless-particle collisions

    E-print Network

    Pavel Spirin; Theodore N. Tomaras

    2015-06-27

    The angular and frequency characteristics of the gravitational radiation emitted in collisions of massless particles is studied perturbatively in the context of classical General Relativity for small values of the ratio $\\alpha\\equiv 2 r_S/b$ of the Schwarzschild radius over the impact parameter. The particles are described with their trajectories, while the contribution of the leading nonlinear terms of the gravitational action is also taken into account. The old quantum results are reproduced in the zero frequency limit $\\omega\\ll 1/b$. The radiation efficiency $\\epsilon \\equiv E_{\\rm rad}/2E$ outside a narrow cone of angle $\\alpha$ in the forward and backward directions with respect to the initial particle trajectories is given by $\\epsilon \\sim \\alpha^2$ and is dominated by radiation with characteristic frequency $\\omega \\sim {\\mathcal O}(1/r_S)$.

  8. Gravitational radiation in massless-particle collisions

    E-print Network

    Spirin, Pavel

    2015-01-01

    The angular and frequency characteristics of the gravitational radiation emitted in collisions of massless particles is studied perturbatively in the context of classical General Relativity for small values of the ratio $\\alpha\\equiv 2 r_S/b$ of the Schwarzschild radius over the impact parameter. The particles are described with their trajectories, while the contribution of the leading nonlinear terms of the gravitational action is also taken into account. The old quantum results are reproduced in the zero frequency limit $\\omega\\ll 1/b$. The radiation efficiency $\\epsilon \\equiv E_{\\rm rad}/2E$ outside a narrow cone of angle $\\alpha$ in the forward and backward directions with respect to the initial particle trajectories is given by $\\epsilon \\sim \\alpha^2$ and is dominated by radiation with characteristic frequency $\\omega \\sim {\\mathcal O}(1/r_S)$.

  9. Do Particles have Barcodes?

    NASA Astrophysics Data System (ADS)

    Goradia, Shantilal

    2007-03-01

    If an elementary particle shown in Fig 2 of gr-qc/0507130 has an UNSTABLE quantum connection to the rest of the universe calibrated by nature in terms of Planck times, as also proposed in my separate MAR07 abstract, there exists a possibility that each particle has a barcode of its own. Instability implies varying periods of connections and disconnections of particles to the universe, which would be equivalent to the varying widths of white and black strips of commercial barcodes. Considering the high order of magnitude of Planck times in a second, each particle and the universe generated by its radiations may have their unique birth times registered in their barcodes. My quest for the cause of consciousness, in MAR06 abstracts, as an additional implication of physics/0210040, leads to the inquiry if these unique parallel universes are like the ones that give rise to consciousness as proposed by some physicists. With all due respect, the attempts to explain TOE of inert matter may not be attempts to explain one step to climb up on a stairway at a time. They may be attempts to explain only half a step at a time to on a stairway made with only integer number of steps. The search for TOE assumes such a theory exists. Mathematics has no barrels to fire bullets that can shoot down a non-existent bird. A Hamiltonian knows no consciousness, a missing ingredient of biology made of particles or vice versa, and of realistic TOE.

  10. Particle physics and cosmology

    SciTech Connect

    Kolb, E.W.

    1986-10-01

    This series of lectures is about the role of particle physics in physical processes that occurred in the very early stages of the bug gang. Of particular interest is the role of particle physics in determining the evolution of the early Universe, and the effect of particle physics on the present structure of the Universe. The use of the big bang as a laboratory for placing limits on new particle physics theories will also be discussed. Section 1 reviews the standard cosmology, including primordial nucleosynthesis. Section 2 reviews the decoupling of weakly interacting particles in the early Universe, and discusses neutrino cosmology and the resulting limits that may be placed on the mass and lifetime of massive neutrinos. Section 3 discusses the evolution of the vacuum through phase transitions in the early Universe and the formation of topological defects in the transitions. Section 4 covers recent work on the generation of the baryon asymmetry by baryon-number violating reactions in Grand Unified Theories, and mentions some recent work on baryon number violation effects at the electroweak transition. Section 5 is devoted to theories of cosmic inflation. Finally, Section 6 is a discussion of the role of extra spatial dimensions in the evolution of the early Universe. 78 refs., 32 figs., 6 tabs.

  11. Soluble tumor necrosis factor (TNF) receptors p55 and p75 and interleukin-10 downregulate TNF-alpha activity during the lung response to silica particles in NMRI mice.

    PubMed

    Huaux, F; Arras, M; Vink, A; Renauld, J C; Lison, D

    1999-07-01

    We have found reduced activity of tumor necrosis factor (TNF)-alpha accompanying resolving and fibrosing alveolitis induced in NMRI mice by mineral particles (MnO2 and SiO2, respectively), which is in apparent contradiction to the well-recognized proinflammatory and profibrotic activities of this cytokine. The objective of this study was to examine the mechanisms involved in this paradoxical response in NMRI mice. Although lung tissue messenger RNA (mRNA) levels for TNF-alpha were transiently (up to 15 d) and persistently (up to 120 d) upregulated in the resolving and fibrosing models, respectively, these changes were not accompanied by a parallel release of TNF-alpha protein, which was respectively transiently and persistently downregulated in bronchoalveolar lavage fluid and bronchoalveolar lavage cell cultures. The downregulation of the TNF-alpha protein was concurrent with the accumulation of recruited polymorphonuclear neutrophils (PMNs) in alveoli, and coculture experiments showed that PMN explanted from the lungs of mice treated with silica particles were able to downregulate the expression of TNF-alpha protein by naive alveolar macrophages. In addition, PMN depletion prevented the downregulation of TNF-alpha induced by silica, further establishing the role of PMNs in the downregulation of TNF-alpha. The possible degradation of TNF-alpha by proteolytic enzymes could be excluded. Marked increases in soluble p55 and p75 TNF receptors (sTNF-R), as well as in interleukin (IL)-10, paralleled the downregulation of TNF-alpha protein. The role of these mediators in the observed reduction of TNF-alpha activity was confirmed by immunoneutralizing the activity of p55 and p75 sTNF-R and by using IL-10-deficient animals. Because IL-10 also exerts profibrotic activity in addition to its antiinflammatory activity, the protracted overproduction of IL-10 observed in fibrosing alveolitis may help the understanding of why, in NMRI mice treated with silica particles, lung fibrosis develops in association with a downregulation of TNF-alpha. PMID:10385602

  12. Individual Particle Morphology and Acidity

    Microsoft Academic Search

    Esther Coz; Begoña Artíñano; Allen L. Robinson; Gary S. Casuccio; Traci L. Lersch; Spyros N. Pandis

    2008-01-01

    The morphological characterization of particles during the Pittsburgh Air Quality Study (PAQS) suggests that particle shape and physical state depends on their acidity. The aerosol shape parameters measured by Computer-Controlled Scanning Electron Microscopy (CCSEM) are statistically different in periods when atmospheric particles are neutral and when they are acidic. High concentrations of particles smaller than 500 nm with high sulfur

  13. Non-accelerator Particle Physics

    E-print Network

    Wechsler, Risa H.

    Non-accelerator Particle Physics and Neutrino Physics Research programs of: Prof. Martin that often connect particle physics with astrophysics and cosmology Some questions: - What particles of the neutrino? #12;The techniques: Laboratory experiments, in the style of particle physics · High energy

  14. Solar Flares and particle acceleration

    E-print Network

    Solar Flares and particle acceleration Eduard Kontar School of Physics and Astronomy University and accelerated particles #12;Solar flares and accelerated particles From Emslie et al., 2004, 2005 Free magnetic Spectroscopic Imager RHESSI is designed to investigate particle acceleration and energy release in solar flares

  15. Ice nucleation on soot particles

    Microsoft Academic Search

    B Gorbunov; A Baklanov; N Kakutkina; H. L Windsor; R Toumi

    2001-01-01

    The ice-forming activity of soot particles of various sizes has been studied in a cloud chamber under temperatures ranging from ?5 to ?20°C. It was found that the fraction of aerosol particles forming ice crystals was influenced by the temperature, the mean radius of aerosol particles and the degree of oxidising of the soot particle surface. It was suggested that

  16. Supertwistors and massive particles

    E-print Network

    Luca Mezincescu; Alasdair J. Routh; Paul K. Townsend

    2014-04-24

    In the (super)twistor formulation of massless (super)particle mechanics, the mass-shell constraint is replaced by a "spin-shell" constraint from which the spin content can be read off. We extend this formalism to massive (super)particles (with N-extended spacetime supersymmetry) in three and four space-time dimensions, explaining how the spin-shell constraints are related to spin, and we use it to prove equivalence of the massive N=1 and BPS-saturated N=2 superparticle actions. We also find the supertwistor form of the action for "spinning particles" with N-extended worldline supersymmetry, massless in four dimensions and massive in three dimensions, and we show how this simplifies special features of the N=2 case.

  17. Biological particle identification apparatus

    DOEpatents

    Salzman, Gary C. (Los Alamos, NM); Gregg, Charles T. (Los Alamos, NM); Grace, W. Kevin (Los Alamos, NM); Hiebert, Richard D. (Los Alamos, NM)

    1989-01-01

    An apparatus and method for making multiparameter light scattering measurements from suspensions of biological particles is described. Fourteen of the sixteen Mueller matrix elements describing the particles under investigation can be substantially individually determined as a function of scattering angle and probing radiations wavelength, eight elements simultaneously for each of two apparatus configurations using an apparatus which incluees, in its simplest form, two polarization modulators each operating at a chosen frequency, one polarizer, a source of monochromatic electromagnetic radiation, a detector sensitive to the wavelength of radiation employed, eight phase-sensitive detectors, and appropriate electronics. A database of known biological particle suspensions can be assembled, and unknown samples can be quickly identified once measurements are performed on it according to the teachings of the subject invention, and a comparison is made with the database.

  18. On particle track detectors

    NASA Technical Reports Server (NTRS)

    Benton, E. V.; Gruhn, T. A.; Andrus, C. H.

    1973-01-01

    Aqueous sodium hydroxide is widely used to develop charged particle tracks in polycarbonate film, particularly Lexan. The chemical nature of the etching process for this system has been determined. A method employing ultra-violet absorbance was developed for monitoring the concentration of the etch products in solution. Using this method it was possible to study the formation of the etching solution saturated in etch products. It was found that the system super-saturates to a significant extent before precipitation occurs. It was also learned that the system approaches its equilibrium state rather slowly. It is felt that both these phenomena may be due to the presence of surfactant in the solution. In light of these findings, suggestions are given regarding the preparation and maintenance of the saturated etch solution. Two additional research projects, involving automated techniques for particle track analysis and particle identification using AgCl crystals, are briefly summarized.

  19. Charged particle accelerator grating

    DOEpatents

    Palmer, R.B.

    1985-09-09

    A readily disposable and replaceable accelerator grating for a relativistic particle accelerator is described. The grating is formed for a plurality of liquid droplets that are directed in precisely positioned jet streams to periodically dispose rows of droplets along the borders of a predetermined particle beam path. A plurality of lasers are used to direct laser beams onto the droplets, at predetermined angles, thereby to excite the droplets to support electromagnetic accelerating resonances on their surfaces. Those resonances operate to accelerate and focus particles moving along the beam path. As the droplets are distorted or destroyed by the incoming radiation, they are replaced at a predetermined frequency by other droplets supplied through the jet streams.

  20. The Review of Particle Physics

    NSDL National Science Digital Library

    The Particle Physics Group (PDG) is an "international collaboration that reviews particle physics and related areas of Astrophysics, and compiles/analyzes data on particle properties." The Web site features the 2002 publication, The Review of Particle Physics, which is described as "the most cited publication in particle physics during the last decade." Visitors have access to summary tables and conservation laws; reviews, tables, and plots; and particle listings, which list, average, evaluate, and reference various data used. Other features include a link to particle physics information and databases, archives of past reports, and other helpful resources.

  1. Wave-particle Interactions In Rotating Mirrors

    SciTech Connect

    Abraham J. Fetterman and Nathaniel J. Fisch

    2011-01-11

    Wave-particle interactions in E×B rotating plasmas feature an unusual effect: particles are diffused by waves in both potential energy and kinetic energy. This wave-particle interaction generalizes the alpha channeling effect, in which radio frequency waves are used to remove alpha particles collisionlessly at low energy. In rotating plasmas, the alpha particles may be removed at low energy through the loss cone, and the energy lost may be transferred to the radial electric field. This eliminates the need for electrodes in the mirror throat, which have presented serious technical issues in past rotating plasma devices. A particularly simple way to achieve this effect is to use a high azimuthal mode number perturbation on the magnetic field. Rotation can also be sustained by waves in plasmas without a kinetic energy source. This type of wave has been considered for plasma centrifuges used for isotope separation. Energy may also be transferred from the electric field to particles or waves, which may be useful for ion heating and energy generation.

  2. Charged Particle in Capacitor

    NSDL National Science Digital Library

    In this interactive simulation, the path of a charged particle in a capacitor can be traced. Users may adjust the strength of field, initial velocity and mass of the moving particle, and magnitude of its charge. The simulated path can be viewed in continuous or step mode, with or without a vector display of the position, velocity, acceleration, or force. Also available for display are bar graphs depicting kinetic and potential energy. This item is part of a larger collection of physics simulations sponsored by the MAP project (Modular Approach to Physics).

  3. Particle Physics in the UK

    NSDL National Science Digital Library

    Supported by the Particle Physics and Astronomy Research Council, this website was created to educate everyone about particle physics. Individuals can find archived press releases, news articles, and particle physics pictures. The website summarizes the role of particle physics in industry and offers links to educational and employment opportunities. Students and educators can find out about famous physicists and the principles of particle physics and its history. Scientists can locate high energy physics universities, groups, and experiments.

  4. Diesel exhaust particles induce the over expression of tumor necrosis factor-alpha (TNF-alpha) gene in alvelor machrophage and failed to induce apoptosis through activation of nuclear factor-kappaB (NF-kappaB)

    EPA Science Inventory

    Exposure to particulate matter (PM2.5-10), including diesel exhaust particles (DEP) has been reported to induce lung injury and exacerbation of asthma and chronic obstructive pulmonary disease. Alveolar macrophages play a major role in the lung's response to inhaled particles and...

  5. Insights into particle cycling from thorium and particle data.

    PubMed

    Lam, Phoebe J; Marchal, Olivier

    2015-01-01

    Marine particles are a main vector by which the biological carbon pump in the ocean transfers carbon from the atmosphere to the deep ocean. Marine particles exist in a continuous spectrum of sizes, but they can be functionally grouped into a small, suspended class (which constitutes most of the total particle mass) and a large, sinking class (which contributes most of the particle flux). These two classes are connected by aggregation and disaggregation processes. The interplay of processes that create, aggregate, and destroy marine particles determines the strength and transfer efficiency of the biological pump. Measurements of radiocarbon, barium, and organic biomarkers on suspended and sinking particles have provided qualitative insights into particle dynamics, and measurements of thorium isotopes have provided quantitative estimates of rates. Here, we review what has been learned so far about particle dynamics in the ocean from chemical measurements on suspended and sinking particles. We then discuss future directions for this approach. PMID:25251275

  6. m anchester particle physics

    E-print Network

    m anchester particle physics MAN/HEP/97­1 3rd January, 1997 Four­fermion events in electron of Physics Manchester University Manchester M13 9PL England Abstract A study of neutral­current four­fermion at DPF '96, Minneapolis #12; 1 Introduction Four­fermion processes are important as a background to Higgs

  7. Deliquescence of small particles

    NASA Astrophysics Data System (ADS)

    Russell, Lynn M.; Ming, Yi

    2002-01-01

    The deliquescence of particles smaller than 100 nm in diameter from crystalline form to liquid droplets involves both solvation effects and surface energies. Here we study this phenomenon for the case of salt particles of initial dry diameters from 8 to 100 nm that are exposed to humid conditions from 45 to 95% relative humidity. With a simple thermodynamic equilibrium model for three soluble species (sodium chloride, ammonium sulfate, and a soluble organic compound), we show that the role of surface tension is to increase the relative humidity at which particles will deliquesce. For example, 15 nm dry diameter sodium chloride particles deliquesce at 83%, an 8% increase over the 75% deliquescence relative humidity for supermicron droplets and bulk solution. Many soluble species in air above 45% relative humidity are wetted with multiple layers of water molecules such that the relevant interface is that between the partially dissolved salt crystal and a saturated salt solution rather than between the dry crystal and air. Since surface tensions for this solid/liquid interface are not well known, a range of values have been used from the literature, yielding consistent results. While the existence of unstable equilibria during deliquescence of the system precludes complete experimental verification of the predicted behavior with measurements, a recent experiment suggests indirect agreement with the change in predicted deliquescence relative humidity.

  8. FPGA Particle Graphics Hardware

    Microsoft Academic Search

    John Sachs Beeckler; Warren J. Gross

    2005-01-01

    Particle graphics simulations are well suited for model- ing phenomena such as water, cloth, explosions, fire, smoke, and clouds. They are normal realized in software, as part of an interactive graphics application, such as a video game. Their use in such applications is limited by the computa- tional burden and resource competition they create for a host application. We present

  9. Lunar Soil Particle Separator

    NASA Technical Reports Server (NTRS)

    Berggren, Mark

    2010-01-01

    The Lunar Soil Particle Separator (LSPS) beneficiates soil prior to in situ resource utilization (ISRU). It can improve ISRU oxygen yield by boosting the concentration of ilmenite, or other iron-oxide-bearing materials found in lunar soils, which can substantially reduce hydrogen reduction reactor size, as well as drastically decreasing the power input required for soil heating

  10. Dynamic particle holographic instrument

    Microsoft Academic Search

    Guozhi Wang; San Feng; Zhengrong Wang; Shuyan Wang

    1991-01-01

    The sizes, distributions, and speeds of sprayed particles can be ascertained under various circumstances through the use of the in-line\\/off-axis holography and sequential pulse laser system discussed. The optical system used is of multifunctional architecture, allowing either the making of a reflecting object's hologram or serving as a holographic interferometer for transparent objects and fluid fields. The light source used

  11. Elementary Particles and Forces.

    ERIC Educational Resources Information Center

    Quigg, Chris

    1985-01-01

    Discusses subatomic particles (quarks, leptons, and others) revealed by higher accelerator energies. A connection between forces at this subatomic level has been established, and prospects are good for a description of forces that encompass binding atomic nuclei. Colors, fundamental interactions, screening, camouflage, electroweak symmetry, and…

  12. Photons as quasicharged particles

    Microsoft Academic Search

    K.-P. Marzlin; Jürgen Appel; A. I. Lvovsky

    2008-01-01

    The Schrödinger motion of a charged quantum particle in an electromagnetic potential can be simulated by the paraxial dynamics of photons propagating through a spatially inhomogeneous medium. The inhomogeneity induces geometric effects that generate an artificial vector potential to which signal photons are coupled. This phenomenon can be implemented with slow light propagating through a gas of double- Lambda atoms

  13. Particles causing lung disease

    SciTech Connect

    Kilburn, K.H.

    1984-04-01

    The lung has a limited number of patterns of reaction to inhaled particles. The disease observed depends upon the location: conducting airways, terminal bronchioles and alveoli, and upon the nature of inflammation induced: acute, subacute or chronic. Many different agents cause narrowing of conducting airways (asthma) and some of these cause permanent distortion or obliteration of airways as well. Terminal bronchioles appear to be particularly susceptible to particles which cause goblet cell metaplasia, mucous plugging and ultimately peribronchiolar fibrosis. Cancer is the last outcome at the bronchial level and appears to depend upon continuous exposure to or retention of an agent in the airway and failure of the affected cells to be exfoliated which may be due to squamous metaplasia. Alveoli are populated by endothelial cells, Type I or pavement epithelial cells and metabolically active cuboidal Type II cells that produce the lungs specific surfactant, dipalmytol lecithin. Disturbances of surfactant lead to edema in distal lung while laryngeal edema due to anaphylaxis or fumes may produce asphyxia. Physical retention of indigestible particles or retention by immune memory responses may provoke hyaline membranes, stimulate alveolar lipoproteinosis and finally fibrosis. This later exuberant deposition of connective tissue has been best studied in the occupational pneumoconioses especially silicosis and asbestosis. In contrast emphysema a catabolic response appears frequently to result from leakage or release of lysosomal proteases into the lung during processing of cigarette smoke particles. 164 references, 1 figure, 2 tables.

  14. Tetrahedrons by Patchy Particles

    NSDL National Science Digital Library

    Zhang, Zhenli

    2005-01-31

    Simulation Software: Glotzer Group Code Simulation Method: Brownian Dynamics A system of 24 spherical particles with patch of double patches at a concentration of 0.20, was run starting at an effectively infinite temperature then instantaneously quenched to a temperature of 0.88. The final equillibrium structure is tetrahedrons. Simulation Model: United Atom Rigid Body with Lennard-Jones

  15. Wires by Patchy Particles

    NSDL National Science Digital Library

    Zhang, Zhenli

    2005-01-31

    Simulation Software: Glotzer Group Code Simulation Method: Brownian Dynamics A system of 80 spherical particles with two patches at a concentration of 0.20, was run starting at an effectively infinite temperature then instantaneously quenched to a temperature of 0.5. The final equillibrium structure is wires or chains. Simulation Model: United Atom Rigid Body with Lennard-Jones

  16. Rings by Patchy Particles

    NSDL National Science Digital Library

    Zhang, Zhenli

    2005-01-31

    Simulation Software: Glotzer Group Code Simulation Method: Brownian Dynamics A system of 90 spherical particles with two patterned linear patches at a concentration of 0.20, was run starting at an effectively infinite temperature then instantaneously quenched to a temperature of 0.33. The final equillibrium structure is rings. Simulation Model: United Atom Rigid Body with Lennard-Jones

  17. Icosahedrons by Patchy Particles

    NSDL National Science Digital Library

    Zhang, Zhenli

    2005-01-31

    Simulation Software: Glotzer Group Code Simulation Method: Brownian Dynamics A system of 24 spherical particles with patch of double patches at a concentration of 0.20, was run starting at an effectively infinite temperature then instantaneously quenched to a temperature of 0.88. The final equillibrium structure is icosahedron terminated clusters. Simulation Model: United Atom Rigid Body with Lennard Jones

  18. Particle-Size Analysis

    SciTech Connect

    Gee, Glendon W. (BATTELLE (PACIFIC NW LAB)); Or, Dani (Utah State University); J.H. Dane and G.C. Topp

    2002-11-01

    Book Chapter describing methods of particle-size analysis for soils. Includes a variety of classification schemes. Standard methods for size distributions using pipet and hydrometer techniques are described. New laser-light scattering and related techniques are discussed. Complete with updated references.

  19. Particle Acceleration in Jets

    NASA Technical Reports Server (NTRS)

    Nishikawa, Ken-Ichi

    2005-01-01

    Nonthermal radiation observed from astrophysical systems containing relativistic jets and shocks, e.g., active galactic nuclei (AGNs), gamma ray burst (GRBs), and Galactic microquasar systems usually have power-law emission spectra. Fermi acceleration is the mechanism usually assumed for the acceleration of particles in astrophysical environments.

  20. m anchester particle physics

    E-print Network

    an error then the maximum number of useful samples is of order (N=n) 2 . #12; 1. Introduction The bootstrapm anchester particle physics MAN/HEP/99/4 April 14, 2000 Application of the Bootstrap resampling Manchester M13 9PL England Abstract When using the Monte Carlo Bootstrap technique to estimate the mean