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Sample records for partner nuclear profile

  1. Sister Lab Program Prospective Partner Nuclear Profile: Indonesia

    SciTech Connect

    Bissani, M; Tyson, S

    2006-12-14

    Indonesia has participated in cooperative technical programs with the IAEA since 1957, and has cooperated with regional partners in all of the traditional areas where nuclear science is employed: in medicine, public health (such as insect control and eradication programs), agriculture (e.g. development of improved varieties of rice), and the gas and oil industries. Recently, Indonesia has contributed significantly to the Reduced Enrichment Research and Training Reactor (RERTR) Program by conducting experiments to confirm the feasibility of Mo-99 production using high-density low enriched uranium (LEU) fuel, a primary goal of the RERTR Program. Indonesia's first research reactor, the TRIGA Mark II at Bandung, began operation in 1964 at 250 kW and was subsequently upgraded in 1971 to 1 MW and further upgraded in 2000 to 2 MW. This reactor was joined by another TRIGA Mark II, the 100-kW Kartini-PPNY at Yogyakarta, in 1979, and by the 30-MW G.A. Siwabessy multipurpose reactor in Serpong, which achieved criticality in July 1983. A 10-MW radioisotope production reactor, to be called the RPI-10, also was proposed for construction at Serpong in the late 1990s, but the project apparently was not carried out. In the five decades since its nuclear research program began, Indonesia has trained a cadre of scientific and technical staff who not only operate and conduct research with the current facilities, but also represent the nucleus of a skilled labor pool to support development of a nuclear power program. Although Indonesia's previous on-again, off-again consideration of nuclear power has not gotten very far in the past, it now appears that Indonesia again is giving serious consideration to beginning a national nuclear energy program. In June 2006, Research and Technology Minister Kusmayanto Kadiman said that his ministry was currently putting the necessary procedures in place to speed up the project to acquire a nuclear power plant, indicating that, ''We will need around

  2. Sister Lab Program Prospective Partner Nuclear Profile: Malaysia

    SciTech Connect

    Bissani, M; Tyson, S

    2006-12-14

    The Malaysian Deputy Prime Minister Tun Dr Ismail Abdul Rahman suggested in the early 1970s that Malaysia should have a role in the development of nuclear science and technology for peaceful purposes. Accordingly, the Center for the Application of Nuclear Energy (CRANE) was established, with a focus on the development of a scientific and technical pool critical to a national nuclear power program. The Malaysian Cabinet next established the Tun Ismail Atomic Research Center (TIARC) under the Ministry of Science, Technology and the Environment on 19 September 1972, at a site in Bangi, about 35 km south of Kuala Lampur. On 28 June 1982, the PUSPATI reactor, a 1-MW TRIGA MK-II research reactor, first reached criticality. On 10 August 1994, TIARC was officially renamed as the Malaysian Institute for Nuclear Technology Research (MINT). In addition to radioisotope production and neutron radiography conducted at the PUSPATI research reactor, MINT also supports numerous programs employing nuclear technology for medicine, agriculture and industry, and has been involved in both bilateral and multilateral technical cooperation to extend its capabilities. As an energy exporting country, Malaysia has felt little incentive to develop a nuclear energy program, and high level opposition within the government discouraged it further. A recent statement by Malaysia's Science, Technology and Innovation Minister supported this view, indicating that only a near-catastrophic jump in world oil prices might change the government's view. However, the rate at which Malaysia is using its natural gas and oil reserves is expected to force it to reassess the role of nuclear energy in the near future. In addition, the government does intend to construct a radioactive waste repository to dispose of naturally occurring radioactive materials (extracted during tin mining, in particular). Also, Malaysia's growing economy could encourage expansion in Malaysia's existing nuclear-applications programs

  3. Sister Lab Program Prospective Partner Nuclear Profile: Vietnam

    SciTech Connect

    Bissani, M; Tyson, S

    2006-12-14

    Vietnam's nuclear program began in the 1960s with the installation at Dalat of a 250 kW TRIGA Mk-II research reactor under the U.S. Atoms for Peace Program. The reactor was shut down and its core removed only a few years later, and the nuclear research program was suspended until after the end of the civil war in the late 1970s. The Soviet Union assisted Vietnam in restoring the Dalat reactor to an operational status in 1984, trained a cadre of scientific and technical staff in its operation, and contributed to the development of nuclear science for the medical and agricultural sectors. In the agricultural area in particular, Vietnamese experts have been very successful in developing mutant strains of rice, and continue to work with the IAEA to yield strains that have a shorter growing period, increased resistance to disease, and other desirable characteristics. Rice has always been the main crop in Vietnam, but technical cooperation with the IAEA and other states has enabled the country to become one of the top rice producers in the world, exporting much of its annual crop to over two dozen countries annually. More recently, Vietnam's government has shown increasing interest in developing a civil nuclear program to supplement its fossil fuel and other energy resources. Projections from a variety of open sources, ranging from the IAEA, the U.S. Department of Energy's Energy Information Administration (EIA), the Vietnamese government, energy corporations, and think tanks all predict a massive increase in energy consumption--especially electricity--within Vietnam and the region as a whole. This growth in consumption will require a corresponding increase in energy production, which in Vietnam is currently satisfied mainly by fossil fuels (coal) and renewable energy (hydropower and biomass); Vietnam has a refining capacity of about 800 barrels/day. Most of its crude oil is exported to generate export income, and is not used to generate electricity. Although Vietnam is

  4. "Are we Facebook official?" Implications of dating partners' Facebook use and profiles for intimate relationship satisfaction.

    PubMed

    Papp, Lauren M; Danielewicz, Jennifer; Cayemberg, Crystal

    2012-02-01

    Extending previous research on positive and negative correlates of Facebook use for individuals' outcomes, this study examined male and female dating partners' (n=58 couples) Facebook use and portrayals of their intimate relationship on the Facebook profile. Confirming hypotheses from compatibility theories of mate selection, partners demonstrated similar Facebook intensity (e.g., usage, connection to Facebook), and were highly likely to portray their relationship on their Facebook profiles in similar ways (i.e., display partnered status and show their partner in profile picture). These Facebook profile choices played a role in the overall functioning of the relationship, with males' indications of a partnered status linked with higher levels of their own and their partners' (marginal) relationship satisfaction, and females' displays of their partner in their profile picture linked with higher levels of their own and their partners' relationship satisfaction. Finally, male and female reports of having had disagreements over the Facebook relationship status was associated with lower level of females' but not males' relationship satisfaction, after accounting for global verbal conflict. Thus, the findings point to the unique contribution of Facebook disagreements to intimate relationship functioning. Results from this study encourage continued examination of technology use and behaviors in contexts of intimate relationships. PMID:21988733

  5. Anger Problem Profiles among Partner Violent Men: Differences in Clinical Presentation and Treatment Outcome

    ERIC Educational Resources Information Center

    Murphy, Christopher M.; Taft, Casey T.; Eckhardt, Christopher I.

    2007-01-01

    Cluster analysis of 139 partner violent men's self-reports on the State-Trait Anger Expression Inventory identified profiles reflecting pathological anger (PA), low anger control (LAC), and normal anger (NA). The PA group self-reported higher pretreatment partner abuse, interpersonal dysfunction, distress, and substance abuse and had lower…

  6. Police Attitudes toward Policing Partner Violence against Women: Do They Correspond to Different Psychosocial Profiles?

    ERIC Educational Resources Information Center

    Gracia, Enrique; Garcia, Fernando; Lila, Marisol

    2011-01-01

    This study analyzed whether police attitudes toward policing partner violence against women corresponded with different psychosocial profiles. Two attitudes toward policing partner violence were considered--one reflecting a general preference for a conditional law enforcement (depending on the willingness of the victim to press charges against the…

  7. Perceived Partner Responsiveness Predicts Diurnal Cortisol Profiles 10 Years Later

    PubMed Central

    Slatcher, Richard B.; Selcuk, Emre; Ong, Anthony D.

    2015-01-01

    Several decades of research have demonstrated that marital relationships have a powerful influence on physical health. However, surprisingly little is known about how marriage affects health—both in terms of psychological processes and biological ones. We investigated the associations between perceived partner responsiveness—the extent to which people feel understood, cared for and appreciated by their romantic partner—and diurnal cortisol over a 10-year period in a large sample of married and cohabitating couples in the U.S. Partner responsiveness predicted higher wakeup cortisol values and steeper (“healthier”) cortisol slopes at the 10-year follow-up, and these associations remained strong after controlling for demographic factors, depressive symptoms, agreeableness, and other positive and negative relationship factors. Further, declines in negative affect over the 10-year period mediated the prospective association between responsiveness and cortisol slope. These findings suggest that diurnal cortisol may be a key biological pathway through which social relationships impact long-term health. PMID:26015413

  8. Partners.

    PubMed

    Westover, P F

    1986-01-01

    The Salt Lake Clinic's problem was one of balance. Although the organizational values of the clinic were well developed, the organizational structure was not. The board of directors historically was accountable to its partners or shareholders, but the competitive, consumer-oriented environment also called for recognition of community, business, and consumer interest. To achieve a more balanced approach to clinic governance, a lay advisory board was appointed, made up of members active in civic affairs who each had a unique contribution to make and represented a business, community, or consumer perspective. PMID:10278455

  9. Latent profiles of perceived time adequacy for paid work, parenting, and partner roles.

    PubMed

    Lee, Soomi; Almeida, David M; Davis, Kelly D; King, Rosalind B; Hammer, Leslie B; Kelly, Erin L

    2015-10-01

    This study examined feelings of having enough time (i.e., perceived time adequacy) in a sample of employed parents (N = 880) in information technology and extended-care industries. Adapting a person-centered latent profile approach, we identified 3 profiles of perceived time adequacy for paid work, parenting, and partner roles: family time protected, family time sacrificed, and time balanced. Drawing upon the conservation of resources theory (Hobfòll, 1989), we examined the associations of stressors and resources with the time adequacy profiles. Parents in the family time sacrificed profile were more likely to be younger, women, have younger children, work in the extended-care industry, and have nonstandard work schedules compared to those in the family time protected profile. Results from multinomial logistic regression analyses revealed that, with the time balanced profile as the reference group, having fewer stressors and more resources in the family context (less parent-child conflict and more partner support), work context (longer company tenure, higher schedule control and job satisfaction), and work-family interface (lower work-to-family conflict) was linked to a higher probability of membership in the family time protected profile. By contrast, having more stressors and fewer resources, in the forms of less partner support and higher work-to-family conflict, predicted a higher likelihood of being in the family time sacrificed profile. Our findings suggest that low work-to-family conflict is the most critical predictor of membership in the family time protected profile, whereas lack of partner support is the most important factor to be included in the family time sacrificed profile. PMID:26075739

  10. Distinguishing Risk Profiles among Parent-Only, Partner-Only, and Dually-Perpetrating Physical Aggressors

    PubMed Central

    Smith Slep, Amy M.; O’Leary, Susan G.

    2009-01-01

    This study addressed whether and how men and women who are not physically aggressive, only physically aggressive against their children or their partners, or aggressive against both family members differ in their risk profiles. Risk factors that were unrelated to the partner or parenting role (e.g., impulsivity) and that were specific to one of these roles (e.g., negative parenting attributions, negative partner attributions) were examined using profile analysis. Dually aggressive men and women had the highest overall risk across all types of risk factors; non-aggressive men and women had consistently low risk. Individuals who were aggressive toward only their partners or only their children had distinct risk profiles, with highest levels of risk on the role-specific variable sets. With the exception of parent-only aggressive men, singly aggressive individuals’ risk levels were significantly lower on role-independent and the unrelated role-specific risk than they were on the role-related risk factors. These results suggest theories of partner and parent aggression might gain precision if co-occurrence status were specifically taken into account. PMID:19803606

  11. Oxidative stress-induced assembly of PML nuclear bodies controls sumoylation of partner proteins.

    PubMed

    Sahin, Umut; Ferhi, Omar; Jeanne, Marion; Benhenda, Shirine; Berthier, Caroline; Jollivet, Florence; Niwa-Kawakita, Michiko; Faklaris, Orestis; Setterblad, Niclas; de Thé, Hugues; Lallemand-Breitenbach, Valérie

    2014-03-17

    The promyelocytic leukemia (PML) protein organizes PML nuclear bodies (NBs), which are stress-responsive domains where many partner proteins accumulate. Here, we clarify the basis for NB formation and identify stress-induced partner sumoylation as the primary NB function. NB nucleation does not rely primarily on intermolecular interactions between the PML SUMO-interacting motif (SIM) and SUMO, but instead results from oxidation-mediated PML multimerization. Oxidized PML spherical meshes recruit UBC9, which enhances PML sumoylation, allow partner recruitment through SIM interactions, and ultimately enhance partner sumoylation. Intermolecular SUMO-SIM interactions then enforce partner sequestration within the NB inner core. Accordingly, oxidative stress enhances NB formation and global sumoylation in vivo. Some NB-associated sumoylated partners also become polyubiquitinated by RNF4, precipitating their proteasomal degradation. As several partners are protein-modifying enzymes, NBs could act as sensors that facilitate and confer oxidative stress sensitivity not only to sumoylation but also to other post-translational modifications, thereby explaining alterations of stress response upon PML or NB loss. PMID:24637324

  12. Elucidating Posttraumatic Stress Symptom Profiles and Their Correlates Among Women Experiencing Bidirectional Intimate Partner Violence

    PubMed Central

    Hellmuth, Julianne C.; Jaquier, Véronique; Swan, Suzanne C.; Sullivan, Tami P.

    2014-01-01

    Objective This study employed latent class analysis to identify profiles of women experiencing intimate partner violence (IPV) based on the severity of posttraumatic stress disorder (PTSD) symptoms. Method Self-report data from a sample of 369 women experiencing bidirectional IPV was used. Results A 3-class solution comprising low, moderate, and high PTSD severity profiles best fit the data. Profiles were differentially related to whether IPV victimization was considered traumatic (PTSD criterion A); whether functioning was impaired as a result of PTSD symptoms (PTSD criterion F); whether the woman met full diagnostic criteria for PTSD; depression symptom severity; and severity of psychological, physical, and sexual IPV victimization and use of IPV. An extremely high percentage of women in the high (96%) and moderate (88%) severity classes experienced functional impairment, although many did not meet full diagnostic criteria for PTSD. Conclusions Findings support the need for interventions individually tailored to one’s treatment needs based on the nature of one’s traumatic stressor and the impact of PTSD on daily functioning. PMID:24752965

  13. In Situ Detection of Interactions Between Nuclear Envelope Proteins and Partners.

    PubMed

    Barateau, Alice; Buendia, Brigitte

    2016-01-01

    Proximity ligation assay (PLA) appears as a quick and easy technique to visualize within fixed cells the occurrence and in situ distribution of protein complexes. PLA has been validated to detect protein-protein interactions within the nuclear compartment. Here, we describe a protocol which allows the detection of interactions between A-type nuclear lamins and either LEM-domain proteins (such as emerin, integrated within the inner nuclear membrane, and LAP2α which accumulates within the nucleoplasm) or gene regulatory factors (e.g., the transcription factor SREBP1). The distinct amounts and patterns of PLA signals obtained for various complexes highlight the pertinence of using PLA to reveal in situ where and to which extent nuclear envelope proteins bind specific partners. PMID:27147040

  14. Oxygen depth profiling by nuclear resonant scattering

    SciTech Connect

    Gibson, G. T.; Sheu, W. J.; Glass, G. A.; Wang, Y. Q.

    1999-06-10

    Nuclear resonance scattering (NRS) {sup 16}O({alpha},{alpha}){sup 16}O at 3.045 MeV ({gamma}=10 keV) has been used for oxygen depth profiling in various thin oxide films. There are two ways by which the oxygen concentration versus depth profile can be obtained from the experimental data: energy spectrum simulation or yield distribution analysis. Energy spectrum simulation is done using the standard RBS software/Rutherford Universal Manipulation Program (RUMP) where only one spectrum is usually needed from the measurement. Yield distribution analysis is accomplished by using a custom developed software/Resonance Analysis Program (RAP) and involves a series of spectra obtained by stepping up the beam energy above the resonance energy. This article aims at comparing the fundamentals of both methods and also discussing their advantages and disadvantages in terms of the data acquisition and the post data analysis. A thermally grown thick SiO{sub 2} film and a thin titanium oxide film grown by corona point discharge were examined.

  15. Oxygen depth profiling by nuclear resonant scattering

    SciTech Connect

    Gibson, G.T.; Sheu, W.J.; Glass, G.A. Wang, Y.Q.

    1999-06-01

    Nuclear resonance scattering (NRS) {sup 16}O({alpha},{alpha}){sup 16}O at 3.045 MeV ({Gamma}=10&hthinsp;keV) has been used for oxygen depth profiling in various thin oxide films. There are two ways by which the oxygen concentration versus depth profile can be obtained from the experimental data: energy spectrum simulation or yield distribution analysis. Energy spectrum simulation is done using the standard RBS software/Rutherford Universal Manipulation Program (RUMP) where only one spectrum is usually needed from the measurement. Yield distribution analysis is accomplished by using a custom developed software/Resonance Analysis Program (RAP) and involves a series of spectra obtained by stepping up the beam energy above the resonance energy. This article aims at comparing the fundamentals of both methods and also discussing their advantages and disadvantages in terms of the data acquisition and the post data analysis. A thermally grown thick SiO{sub 2} film and a thin titanium oxide film grown by corona point discharge were examined. {copyright} {ital 1999 American Institute of Physics.}

  16. A profile of Michigan independent inventors and partnering activity: 1991 survey. Final report

    SciTech Connect

    Eldersveld, B.B.

    1991-12-01

    The Inventors` Council of Michigan created a survey to investigate the use of partnering among independent inventors. A packet consisting of the survey, a cover letter, an informational brochure and a postpaid return envelope was mailed up to 2500 independent inventors selected from the organization`s data base. There were 460 total responses. Of these, the 296 received before the preselected cut-off date were analyzed. The data from these included in the report. Further interviews were conducted with five inventors who had commercialized their inventions with a partner. These case studies led to the conclusion that inventors need to find partners. Although low numbers of inventors actually use partners, the need was expressed for people who can provide skills that inventors lack. These needs include marketing expertise, manufacturing facilities and assistance with financing. Inventors need education and contacts in order to bring their products to market successfully, thereby providing jobs and economic development. Governments should encourage this activity.

  17. A profile of Michigan independent inventors and partnering activity: 1991 survey

    SciTech Connect

    Eldersveld, B.B.

    1991-12-01

    The Inventors' Council of Michigan created a survey to investigate the use of partnering among independent inventors. A packet consisting of the survey, a cover letter, an informational brochure and a postpaid return envelope was mailed up to 2500 independent inventors selected from the organization's data base. There were 460 total responses. Of these, the 296 received before the preselected cut-off date were analyzed. The data from these included in the report. Further interviews were conducted with five inventors who had commercialized their inventions with a partner. These case studies led to the conclusion that inventors need to find partners. Although low numbers of inventors actually use partners, the need was expressed for people who can provide skills that inventors lack. These needs include marketing expertise, manufacturing facilities and assistance with financing. Inventors need education and contacts in order to bring their products to market successfully, thereby providing jobs and economic development. Governments should encourage this activity.

  18. Factors Discriminating among Profiles of Resilience and Psychopathology in Children Exposed to Intimate Partner Violence (IPV)

    ERIC Educational Resources Information Center

    Graham-Bermann, Sandra A.; Gruber, Gabrielle; Howell, Kathryn H.; Girz, Laura

    2009-01-01

    Objective: To evaluate the social and emotional adjustment of 219 children in families with varying levels of intimate partner violence (IPV) using a model of risk and protection. To explore factors that differentiate children with poor adjustment from those with resilience. Methodology: Mothers who experienced IPV in the past year and their…

  19. Personality Profiles of Intimate Partner Violence Offenders with and without PTSD

    ERIC Educational Resources Information Center

    Hoyt, Tim; Wray, Alisha M.; Wiggins, Kathryn T.; Gerstle, Melissa; Maclean, Peggy C.

    2012-01-01

    Intimate partner violence (IPV) is a serious forensic and clinical problem throughout the United States. Research aimed at defining and differentiating subgroups of IPV offenders using standardized personality instruments may eventually help with matching treatments to specific individuals to reduce recidivism. The current study used a convenience…

  20. Bile acids inhibit duodenal secretin expression via orphan nuclear receptor small heterodimer partner (SHP).

    PubMed

    Lam, Ian P Y; Lee, Leo T O; Choi, Hueng-Sik; Alpini, Gianfranco; Chow, Billy K C

    2009-07-01

    Small heterodimer partner (SHP) is an orphan nuclear receptor in which gene expression can be upregulated by bile acids. It regulates its target genes by repressing the transcriptional activities of other nuclear receptors including NeuroD, which has been shown to regulate secretin gene expression. Here, we evaluated the regulation on duodenal secretin gene expression by SHP and selected bile acids, cholic acid (CA) and chenodeoxycholic acid (CDCA). In vitro treatment of CDCA or fexaramine elevated the SHP transcript level and occupancy on secretin promoter. The increase in the SHP level, induced by bile acid treatment or overexpression, reduced secretin gene expression, whereas this gene inhibitory effect was reversed by silencing of endogenous SHP. In in vivo studies, double-immunofluorescence staining demonstrated the coexpression of secretin and SHP in mouse duodenum. Feeding mice with 1% CA-enriched rodent chow resulted in upregulation of SHP and a concomitant decrease in secretin transcript and protein levels in duodenum compared with the control group fed with normal chow. A diet enriched with 5% cholestyramine led to a decrease in SHP level and a corresponding increase in secretin expression. Overall, this study showed that bile acids via SHP inhibit duodenal secretin gene expression. Because secretin is a key hormone that stimulates bile flow in cholangiocytes, this pathway thus provides a novel means to modulate secretin-stimulated choleresis in response to intraduodenal bile acids. PMID:19372104

  1. The orphan nuclear receptor small heterodimer partner mediates male infertility induced by diethylstilbestrol in mice

    PubMed Central

    Volle, David H.; Decourteix, Mélanie; Garo, Erwan; McNeilly, Judy; Fenichel, Patrick; Auwerx, Johan; McNeilly, Alan S.; Schoonjans, Kristina; Benahmed, Mohamed

    2009-01-01

    Studies in rodents have shown that male sexual function can be disrupted by fetal or neonatal administration of compounds that alter endocrine homeostasis, such as the synthetic nonsteroidal estrogen diethylstilbestrol (DES). Although the molecular basis for this effect remains unknown, estrogen receptors likely play a critical role in mediating DES-induced infertility. Recently, we showed that the orphan nuclear receptor small heterodimer partner (Nr0b2), which is both a target gene and a transcriptional repressor of estrogen receptors, controls testicular function by regulating germ cell entry into meiosis and testosterone synthesis. We therefore hypothesized that some of the harmful effects of DES on testes could be mediated through Nr0b2. Here, we present data demonstrating that Nr0b2 deficiency protected mice against the negative effects of DES on testis development and function. During postnatal development, Nr0b2-null mice were resistant to DES-mediated inhibition of germ cell differentiation, which may be the result of interference by Nr0b2 with retinoid signals that control meiosis. Adult Nr0b2-null male mice were also protected against the effects of DES; however, we suggest that this phenomenon was due to the removal of the repressive effects of Nr0b2 on steroidogenesis. Together, these data demonstrate that Nr0b2 plays a critical role in the pathophysiological changes induced by DES in the mouse testis. PMID:19884658

  2. Noninvasive nuclear magnetic resonance profiling of painting layers

    NASA Astrophysics Data System (ADS)

    Presciutti, Federica; Perlo, Juan; Casanova, Federico; Glöggler, Stefan; Miliani, Costanza; Blümich, Bernhard; Brunetti, Brunetto Giovanni; Sgamellotti, Antonio

    2008-07-01

    In this work we demonstrate the potential of single-sided nuclear magnetic resonance (NMR) sensors to access deeper layers of paintings noninvasively by means of high-resolution depth profiles spanning several millimeters. The performance of the sensor in resolving painting structures was tested on models for which excellent agreement with microscopy techniques was obtained. The depth profiling NMR technique was used in situ to investigate old master paintings. The observation of differences in NMR relaxation times of tempera binders from these paintings and from artificially aged panels raises the possibility to differentiate between original and recently restored areas.

  3. A New STAT3-binding Partner, ARL3, Enhances the Phosphorylation and Nuclear Accumulation of STAT3.

    PubMed

    Togi, Sumihito; Muromoto, Ryuta; Hirashima, Koki; Kitai, Yuichi; Okayama, Taichiro; Ikeda, Osamu; Matsumoto, Naoki; Kon, Shigeyuki; Sekine, Yuichi; Oritani, Kenji; Matsuda, Tadashi

    2016-05-20

    Signal transducer and activator of transcription 3 (STAT3) is involved in cell proliferation, differentiation, and cell survival during immune responses, hematopoiesis, neurogenesis, and other biological processes. STAT3 activity is regulated by a variety of mechanisms, including phosphorylation and nuclear translocation. To clarify the molecular mechanisms underlying the regulation of STAT3 activity, we performed yeast two-hybrid screening. We identified ARL3 (ADP-ribosylation factor-like 3) as a novel STAT3-binding partner. ARL3 recognizes the DNA-binding domain as well as the C-terminal region of STAT3 in vivo, and their binding was the strongest when both proteins were activated. Importantly, small interfering RNA-mediated reduction of endogenous ARL3 expression decreased IL-6-induced tyrosine phosphorylation, nuclear accumulation, and transcriptional activity of STAT3. These results indicate that ARL3 interacts with STAT3 and regulates the transcriptional activation of STAT3 by influencing its nuclear accumulation of STAT3. PMID:27048653

  4. Global partnering related to nuclear materials safeguards and security - A pragmatic approach to international safeguards work

    SciTech Connect

    Stanford, Dennis

    2007-07-01

    This paper documents issues Nuclear Fuel Services, Inc. has addressed in the performance of international work to safeguards and security work. It begins with a description of the package we put together for a sample proposal for the Global Threat Reduction Initiative, for which we were ranked number one for technical approach and cost, and concludes with a discussion of approaches that we have taken to performing this work, including issues related to performing the work as part of a team. The primary focus is on communication, workforce, equipment, and coordination issues. Finally, the paper documents the rules that we use to assure the work is performed safely and successfully. (author)

  5. Orphan nuclear receptor small heterodimer partner inhibits transforming growth factor-beta signaling by repressing SMAD3 transactivation.

    PubMed

    Suh, Ji Ho; Huang, Jiansheng; Park, Yun-Yong; Seong, Hyun-A; Kim, Dongwook; Shong, Minho; Ha, Hyunjung; Lee, In-Kyu; Lee, Keesook; Wang, Li; Choi, Hueng-Sik

    2006-12-22

    Orphan nuclear receptor small heterodimer partner (SHP) is an atypical member of the nuclear receptor superfamily; SHP regulates the nuclear receptor-mediated transcription of target genes but lacks a conventional DNA binding domain. In this study, we demonstrate that SHP represses transforming growth factor-beta (TGF-beta)-induced gene expression through a direct interaction with Smad, a transducer of TGF-beta signaling. Transient transfection studies demonstrate that SHP represses Smad3-induced transcription. In vivo and in vitro protein interaction assays revealed that SHP directly interacts with Smad2 and Smad3 but not with Smad4. Mapping of domains mediating the interaction between SHP and Smad3 showed that the entire N-terminal domain (1-159 amino acids) of SHP and the linker domain of Smad3 are involved in this interaction. In vitro glutathione S-transferase pulldown competition experiments revealed the SHP-mediated repression of Smad3 transactivation through competition with its co-activator p300. SHP also inhibits the activation of endogenous TGF-beta-responsive gene promoters, the p21, Smad7, and plasminogen activator inhibitor-1 (PAI-1) promoters. Moreover, adenovirus-mediated overexpression of SHP decreases PAI-1 mRNA levels, and down-regulation of SHP by a small interfering RNA increases both the transactivation of Smad3 and the PAI-1 mRNA levels. Finally, the PAI-1 gene is expressed in SHP(-/-) mouse hepatocytes at a higher level than in normal hepatocytes. Taken together, these data indicate that SHP is a novel co-regulator of Smad3, and this study provides new insights into regulation of TGF-beta signaling. PMID:17074765

  6. A parameterization of nuclear track profiles in CR-39 detector

    NASA Astrophysics Data System (ADS)

    Azooz, A. A.; Al-Nia'emi, S. H.; Al-Jubbori, M. A.

    2012-11-01

    on any theory of liability, whether in contract, strict liability, or tort (including negligence or otherwise) arising in any way out of the use of this software, even if advised of the possibility of such damage. No. of lines in distributed program, including test data, etc.: 15598 No. of bytes in distributed program, including test data, etc.: 3933244 Distribution format: tar.gz Programming language: MATLAB. Computer: Any Desktop or Laptop. Operating system: Windows 1998 or above (with MATLAB R13 or above installed). RAM: 512 Megabytes or higher Classification: 17.5. Nature of problem: A new semispherical parameterization of charged particle tracks in CR-39 SSNTD is carried out in a previous paper. This parameterization is developed here into a MATLAB based software to calculate the track length and track profile for any proton or alpha particle energy or etching time. This software is intended to compete with the TRACK_TEST [1] and TRACK_VISION [2] software currently in use by all people working in the field of SSNTD. Solution method: Based on fitting of experimental results of protons and alpha particles track lengths for various energies and etching times to a new semispherical formula with four free fitting parameters, the best set of energy independent parameters were found. These parameters are introduced into the software and the software is programmed to solve the set of equations to calculate the track depth, track etching rate as a function of both time and residual range for particles of normal and oblique incidence, the track longitudinal profile at both normal and oblique incidence, and the three dimensional track profile at normal incidence. Running time: 1-8 s on Pentium (4) 2 GHz CPU, 3 GB of RAM depending on the etching time value References: [1] ADWT_v1_0 Track_Test Computer program TRACK_TEST for calculating parameters and plotting profiles for etch pits in nuclear track materials. D. Nikezic, K.N. Yu Comput. Phys. Commun. 174(2006)160 [2] AEAF

  7. Profiles of Intimate Partner Violence Victimization, Substance Misuse, and Depression Among Female Caregivers Involved with Child Protective Services

    PubMed Central

    Hellmuth, Julianne C.; Sullivan, Tami P.; Connell, Christian M.

    2014-01-01

    Intimate partner violence (IPV) victimization, substance misuse, and depression are highly prevalent among female caregivers involved with child protective services (CPS). Understanding heterogeneity in the occurrence of these problems is essential to improving pathways to intervention for women in this population. Latent class analysis was employed to determine whether there exist homogeneous subgroups of female caregivers who experience different patterns of IPV victimization, substance misuse, and depression. A restricted three-class solution best fit the data, suggesting high risk, moderate risk, and no risk subgroups. A substantial number of female caregivers comprise the high-risk subgroup (33%) in which caregivers reported very high rates of IPV victimization, substance misuse, and depression. Only a very small proportion comprised the no-risk subgroup (9%). Findings emphasize the heterogeneity among subgroups of female caregivers based on these risk factors, which may have implications for practitioners, such as CPS caseworkers, and researchers alike. PMID:26617433

  8. A parameterization of nuclear track profiles in CR-39 detector

    NASA Astrophysics Data System (ADS)

    Azooz, A. A.; Al-Nia'emi, S. H.; Al-Jubbori, M. A.

    2012-11-01

    on any theory of liability, whether in contract, strict liability, or tort (including negligence or otherwise) arising in any way out of the use of this software, even if advised of the possibility of such damage. No. of lines in distributed program, including test data, etc.: 15598 No. of bytes in distributed program, including test data, etc.: 3933244 Distribution format: tar.gz Programming language: MATLAB. Computer: Any Desktop or Laptop. Operating system: Windows 1998 or above (with MATLAB R13 or above installed). RAM: 512 Megabytes or higher Classification: 17.5. Nature of problem: A new semispherical parameterization of charged particle tracks in CR-39 SSNTD is carried out in a previous paper. This parameterization is developed here into a MATLAB based software to calculate the track length and track profile for any proton or alpha particle energy or etching time. This software is intended to compete with the TRACK_TEST [1] and TRACK_VISION [2] software currently in use by all people working in the field of SSNTD. Solution method: Based on fitting of experimental results of protons and alpha particles track lengths for various energies and etching times to a new semispherical formula with four free fitting parameters, the best set of energy independent parameters were found. These parameters are introduced into the software and the software is programmed to solve the set of equations to calculate the track depth, track etching rate as a function of both time and residual range for particles of normal and oblique incidence, the track longitudinal profile at both normal and oblique incidence, and the three dimensional track profile at normal incidence. Running time: 1-8 s on Pentium (4) 2 GHz CPU, 3 GB of RAM depending on the etching time value References: [1] ADWT_v1_0 Track_Test Computer program TRACK_TEST for calculating parameters and plotting profiles for etch pits in nuclear track materials. D. Nikezic, K.N. Yu Comput. Phys. Commun. 174(2006)160 [2] AEAF

  9. Repression of the nuclear receptor small heterodimer partner by steatotic drugs and in advanced nonalcoholic fatty liver disease.

    PubMed

    Benet, Marta; Guzmán, Carla; Pisonero-Vaquero, Sandra; García-Mediavilla, M Victoria; Sánchez-Campos, Sonia; Martínez-Chantar, M Luz; Donato, M Teresa; Castell, José Vicente; Jover, Ramiro

    2015-04-01

    The small heterodimer partner (SHP) (NR0B2) is an atypical nuclear receptor that lacks a DNA-binding domain. It interacts with and inhibits many transcription factors, affecting key metabolic processes, including bile acid, cholesterol, fatty acid, and drug metabolism. Our aim was to determine the influence of steatotic drugs and nonalcoholic fatty liver disease (NAFLD) on SHP expression and investigate the potential mechanisms. SHP was found to be repressed by steatotic drugs (valproate, doxycycline, tetracycline, and cyclosporin A) in cultured hepatic cells and the livers of different animal models of NAFLD: iatrogenic (tetracycline-treated rats), genetic (glycine N-methyltransferase-deficient mice), and nutritional (mice fed a methionine- and choline-deficient diet). Among the different transcription factors investigated, CCAAT-enhancer-binding protein α (C/EBPα) showed the strongest dominant-repressive effect on SHP expression in HepG2 and human hepatocytes. Reporter assays revealed that the inhibitory effect of C/EBPα and steatotic drugs colocalize between -340 and -509 base pair of the SHP promoter, and mutation of a predicted C/EBPα response element at -473 base pair abolished SHP repression by both C/EBPα and drugs. Moreover, inhibition of major stress signaling pathways demonstrated that the mitogen-activated protein kinase kinase 1/2 pathway activates, while the phosphatidylinositol 3 kinase pathway represses SHP in a C/EBP-dependent manner. We conclude that SHP is downregulated by several steatotic drugs and in advanced NAFLD. These conditions can activate signals that target C/EBPα and consequently repress SHP, thus favoring the progression and severity of NAFLD. PMID:25576488

  10. Women’s Stress, Depression, and Relationship Adjustment Profiles as They Relate to Intimate Partner Violence and Mental Health During Pregnancy and Postpartum

    PubMed Central

    Flanagan, Julianne C.; Gordon, Kristina Coop; Moore, Todd M.; Stuart, Gregory L.

    2014-01-01

    Objective This study applied latent class analysis to examine whether homogeneous subgroups of women emerged based on their self-reported stress, depression, and relationship adjustment during pregnancy. We also examined whether women in different groups experienced different intimate partner violence (IPV) and mental health symptoms during pregnancy and postpartum. Method 180 women completed assessments during the first 18 weeks of pregnancy and 122 completed follow-up assessments six weeks postpartum. Results A two-class solution best fit the data. One group reported higher mean stress and depression and poorer relationship adjustment compared to the other group. The high severity class reported more psychological IPV victimization and perpetration and more physical IPV victimization during pregnancy compared to the low severity class. Membership in the high severity class was associated with higher postpartum depression. Conclusions Findings highlight the associations between different profiles of mental and relational health during pregnancy and postpartum. Future studies should explore the utility of dyadic interventions aimed at reducing stress, depression, and IPV, and improving relationship adjustment as a means to improve women’s health during pregnancy and postpartum. These findings also highlight the potential utility of applying person-centered analytic approaches to the study of women’s and couples’ health during this time period. PMID:25642352

  11. Nuclear microprobe analysis of lead profile in crocodile bones

    NASA Astrophysics Data System (ADS)

    Orlic, I.; Siegele, R.; Hammerton, K.; Jeffree, R. A.; Cohen, D. D.

    2003-09-01

    Elevated concentrations of lead were found in Australian free ranging saltwater crocodile ( Crocodylus porosus) bone and flesh. Lead shots were found as potential source of lead in these animals. ANSTO's heavy ion nuclear microprobe was used to measure the distribution of Pb in a number of bones and osteoderms. The aim was to find out if elevated Pb concentration remains in growth rings and if the concentration is correlated with the blood levels recorded at the time. Results of our study show a very distinct distribution of accumulated Pb in bones and osteoderms as well as good correlation with the level of lead concentration in blood. To investigate influence of ion species on detection limits measurements of the same sample were performed by using 3 MeV protons, 9 MeV He ions and 20 MeV carbon ions. Peak to background ratios, detection limits and the overall 'quality' of obtained spectra are compared and discussed.

  12. Civic Partners.

    ERIC Educational Resources Information Center

    Pew Partnership for Civic Change, Charlottesville, VA.

    This issue of "Civic Partners" is a call to action on behalf of American's cities. The issue opens with John W. Gardner's discussion of the "responsibles" whose vision and energy sustain communities. He stresses that all of us are "responsibles." Among the many tasks that face those responsible for urban improvement is the teaching of conflict…

  13. Nup2 requires a highly divergent partner, NupA, to fulfill functions at nuclear pore complexes and the mitotic chromatin region

    PubMed Central

    Markossian, Sarine; Suresh, Subbulakshmi; Osmani, Aysha H.; Osmani, Stephen A.

    2015-01-01

    Chromatin and nuclear pore complexes (NPCs) undergo dramatic changes during mitosis, which in vertebrates and Aspergillus nidulans involves movement of Nup2 from NPCs to the chromatin region to fulfill unknown functions. This transition is shown to require the Cdk1 mitotic kinase and be promoted prematurely by ectopic expression of the NIMA kinase. Nup2 localizes with a copurifying partner termed NupA, a highly divergent yet essential NPC protein. NupA and Nup2 locate throughout the chromatin region during prophase but during anaphase move to surround segregating DNA. NupA function is shown to involve targeting Nup2 to its interphase and mitotic locations. Deletion of either Nup2 or NupA causes identical mitotic defects that initiate a spindle assembly checkpoint (SAC)–dependent mitotic delay and also cause defects in karyokinesis. These mitotic problems are not caused by overall defects in mitotic NPC disassembly–reassembly or general nuclear import. However, without Nup2 or NupA, although the SAC protein Mad1 locates to its mitotic locations, it fails to locate to NPCs normally in G1 after mitosis. Collectively the study provides new insight into the roles of Nup2 and NupA during mitosis and in a surveillance mechanism that regulates nucleokinesis when mitotic defects occur after SAC fulfillment. PMID:25540430

  14. Subcellular RNA profiling links splicing and nuclear DICER1 to alternative cleavage and polyadenylation

    PubMed Central

    Neve, Jonathan; Burger, Kaspar; Li, Wencheng; Hoque, Mainul; Patel, Radhika; Tian, Bin; Gullerova, Monika; Furger, Andre

    2016-01-01

    Alternative cleavage and polyadenylation (APA) plays a crucial role in the regulation of gene expression across eukaryotes. Although APA is extensively studied, its regulation within cellular compartments and its physiological impact remains largely enigmatic. Here, we used a rigorous subcellular fractionation approach to compare APA profiles of cytoplasmic and nuclear RNA fractions from human cell lines. This approach allowed us to extract APA isoforms that are subjected to differential regulation and provided us with a platform to interrogate the molecular regulatory pathways that shape APA profiles in different subcellular locations. Here, we show that APA isoforms with shorter 3′ UTRs tend to be overrepresented in the cytoplasm and appear to be cell-type–specific events. Nuclear retention of longer APA isoforms occurs and is partly a result of incomplete splicing contributing to the observed cytoplasmic bias of transcripts with shorter 3′ UTRs. We demonstrate that the endoribonuclease III, DICER1, contributes to the establishment of subcellular APA profiles not only by expected cytoplasmic miRNA-mediated destabilization of APA mRNA isoforms, but also by affecting polyadenylation site choice. PMID:26546131

  15. Subcellular RNA profiling links splicing and nuclear DICER1 to alternative cleavage and polyadenylation.

    PubMed

    Neve, Jonathan; Burger, Kaspar; Li, Wencheng; Hoque, Mainul; Patel, Radhika; Tian, Bin; Gullerova, Monika; Furger, Andre

    2016-01-01

    Alternative cleavage and polyadenylation (APA) plays a crucial role in the regulation of gene expression across eukaryotes. Although APA is extensively studied, its regulation within cellular compartments and its physiological impact remains largely enigmatic. Here, we used a rigorous subcellular fractionation approach to compare APA profiles of cytoplasmic and nuclear RNA fractions from human cell lines. This approach allowed us to extract APA isoforms that are subjected to differential regulation and provided us with a platform to interrogate the molecular regulatory pathways that shape APA profiles in different subcellular locations. Here, we show that APA isoforms with shorter 3' UTRs tend to be overrepresented in the cytoplasm and appear to be cell-type-specific events. Nuclear retention of longer APA isoforms occurs and is partly a result of incomplete splicing contributing to the observed cytoplasmic bias of transcripts with shorter 3' UTRs. We demonstrate that the endoribonuclease III, DICER1, contributes to the establishment of subcellular APA profiles not only by expected cytoplasmic miRNA-mediated destabilization of APA mRNA isoforms, but also by affecting polyadenylation site choice. PMID:26546131

  16. A new approach to nuclear fuel safeguard enhancement through radionuclide profiling

    NASA Astrophysics Data System (ADS)

    Peterson, Aaron Dawon

    The United States has led the effort to promote peaceful use of nuclear power amongst states actively utilizing it as well as those looking to deploy the technology in the near future. With the attraction being demonstrated by various countries towards nuclear power comes the concern that a nation may have military aspirations for the use of nuclear energy. The International Atomic Energy Agency (IAEA) has established nuclear safeguard protocols and procedures to mitigate nuclear proliferation. The work herein proposed a strategy to further enhance existing safeguard protocols by considering safeguard in nuclear fuel design. The strategy involved the use of radionuclides to profile nuclear fuels. Six radionuclides were selected as identifier materials. The decay and transmutation of these radionuclides were analyzed in reactor operation environment. MCNPX was used to simulate a reactor core. The perturbation in reactivity of the core due to the loading of the radionuclides was insignificant. The maximum positive and negative reactivity change induced was at day 1900 with a value of 0.00185 +/- 0.00256 and at day 2000 with -0.00441 +/- 0.00249, respectively. The mass of the radionuclides were practically unaffected by transmutation in the core; the change in radionuclide inventory was dominated by natural decay. The maximum material lost due to transmutation was 1.17% in Eu154. Extraneous signals from fission products identical to the radionuclide compromised the identifier signals. Eu154 saw a maximum intensity change at EOC and 30 days post-irradiation of 1260% and 4545%, respectively. Cs137 saw a minimum change of 12% and 89%, respectively. Mitigation of the extraneous signals is cardinal to the success of the proposed strategy. The predictability of natural decay provides a basis for the characterization of the signals from the radionuclide.

  17. Profiles.

    ERIC Educational Resources Information Center

    School Arts, 1979

    1979-01-01

    Profiles seven Black, Native American, and Chicano artists and art teachers: Hale A. Woodruff, Allan Houser, Luis Jimenez, Betrand D. Phillips, James E. Pate, I, and Fernando Navarro. This article is part of a theme issue on multicultural art. (SJL)

  18. Benefits of utilizing CellProfiler as a characterization tool for U-10Mo nuclear fuel

    SciTech Connect

    Collette, R.; Douglas, J.; Patterson, L.; Bahun, G.; King, J.; Keiser, D.; Schulthess, J.

    2015-05-01

    Automated image processing techniques have the potential to aid in the performance evaluation of nuclear fuels by eliminating judgment calls that may vary from person-to-person or sample-to-sample. Analysis of in-core fuel performance is required for design and safety evaluations related to almost every aspect of the nuclear fuel cycle. This study presents a methodology for assessing the quality of uranium-molybdenum fuel images and describes image analysis routines designed for the characterization of several important microstructural properties. The analyses are performed in CellProfiler, an open-source program designed to enable biologists without training in computer vision or programming to automatically extract cellular measurements from large image sets. The quality metric scores an image based on three parameters: the illumination gradient across the image, the overall focus of the image, and the fraction of the image that contains scratches. The metric presents the user with the ability to ‘pass’ or ‘fail’ an image based on a reproducible quality score. Passable images may then be characterized through a separate CellProfiler pipeline, which enlists a variety of common image analysis techniques. The results demonstrate the ability to reliably pass or fail images based on the illumination, focus, and scratch fraction of the image, followed by automatic extraction of morphological data with respect to fission gas voids, interaction layers, and grain boundaries.

  19. Benefits of utilizing CellProfiler as a characterization tool for U-10Mo nuclear fuel

    DOE PAGESBeta

    Collette, R.; Douglas, J.; Patterson, L.; Bahun, G.; King, J.; Keiser, D.; Schulthess, J.

    2015-05-01

    Automated image processing techniques have the potential to aid in the performance evaluation of nuclear fuels by eliminating judgment calls that may vary from person-to-person or sample-to-sample. Analysis of in-core fuel performance is required for design and safety evaluations related to almost every aspect of the nuclear fuel cycle. This study presents a methodology for assessing the quality of uranium-molybdenum fuel images and describes image analysis routines designed for the characterization of several important microstructural properties. The analyses are performed in CellProfiler, an open-source program designed to enable biologists without training in computer vision or programming to automatically extract cellularmore » measurements from large image sets. The quality metric scores an image based on three parameters: the illumination gradient across the image, the overall focus of the image, and the fraction of the image that contains scratches. The metric presents the user with the ability to ‘pass’ or ‘fail’ an image based on a reproducible quality score. Passable images may then be characterized through a separate CellProfiler pipeline, which enlists a variety of common image analysis techniques. The results demonstrate the ability to reliably pass or fail images based on the illumination, focus, and scratch fraction of the image, followed by automatic extraction of morphological data with respect to fission gas voids, interaction layers, and grain boundaries.« less

  20. Temperature Profile in Fuel and Tie-Tubes for Nuclear Thermal Propulsion Systems

    SciTech Connect

    Vishal Patel

    2015-02-01

    A finite element method to calculate temperature profiles in heterogeneous geometries of tie-tube moderated LEU nuclear thermal propulsion systems and HEU designs with tie-tubes is developed and implemented in MATLAB. This new method is compared to previous methods to demonstrate shortcomings in those methods. Typical methods to analyze peak fuel centerline temperature in hexagonal geometries rely on spatial homogenization to derive an analytical expression. These methods are not applicable to cores with tie-tube elements because conduction to tie-tubes cannot be accurately modeled with the homogenized models. The fuel centerline temperature directly impacts safety and performance so it must be predicted carefully. The temperature profile in tie-tubes is also important when high temperatures are expected in the fuel because conduction to the tie-tubes may cause melting in tie-tubes, which may set maximum allowable performance. Estimations of maximum tie-tube temperature can be found from equivalent tube methods, however this method tends to be approximate and overly conservative. A finite element model of heat conduction on a unit cell can model spatial dependence and non-linear conductivity for fuel and tie-tube systems allowing for higher design fidelity of Nuclear Thermal Propulsion.

  1. Benefits of utilizing CellProfiler as a characterization tool for U–10Mo nuclear fuel

    SciTech Connect

    Collette, R.; Douglas, J.; Patterson, L.; Bahun, G.; King, J.; Keiser, D.; Schulthess, J.

    2015-07-15

    Automated image processing techniques have the potential to aid in the performance evaluation of nuclear fuels by eliminating judgment calls that may vary from person-to-person or sample-to-sample. Analysis of in-core fuel performance is required for design and safety evaluations related to almost every aspect of the nuclear fuel cycle. This study presents a methodology for assessing the quality of uranium–molybdenum fuel images and describes image analysis routines designed for the characterization of several important microstructural properties. The analyses are performed in CellProfiler, an open-source program designed to enable biologists without training in computer vision or programming to automatically extract cellular measurements from large image sets. The quality metric scores an image based on three parameters: the illumination gradient across the image, the overall focus of the image, and the fraction of the image that contains scratches. The metric presents the user with the ability to ‘pass’ or ‘fail’ an image based on a reproducible quality score. Passable images may then be characterized through a separate CellProfiler pipeline, which enlists a variety of common image analysis techniques. The results demonstrate the ability to reliably pass or fail images based on the illumination, focus, and scratch fraction of the image, followed by automatic extraction of morphological data with respect to fission gas voids, interaction layers, and grain boundaries. - Graphical abstract: Display Omitted - Highlights: • A technique is developed to score U–10Mo FIB-SEM image quality using CellProfiler. • The pass/fail metric is based on image illumination, focus, and area scratched. • Automated image analysis is performed in pipeline fashion to characterize images. • Fission gas void, interaction layer, and grain boundary coverage data is extracted. • Preliminary characterization results demonstrate consistency of the algorithm.

  2. Lipoprotein Particle Profiles by Nuclear Magnetic Resonance Spectroscopy in Medically-Underserved HIV-Infected Persons

    PubMed Central

    Swanson, Barbara; Sha, Beverly E.; Keithley, Joyce K.; Fogg, Louis; Nerad, Judith; Novak, Richard; Adeyemi, Oluwatoyin

    2009-01-01

    Background HIV infection is associated with dyslipidemia and increased risk for cardiovascular events. Few studies have described lipid status in medically-underserved, HIV-infected ethnic minorities, a group that is characterized by health disparities. Objective The objective was to characterize the lipid profile of a medically-underserved, largely ethnic minority sample of HIV-infected persons using standard lipid panels and nuclear magnetic resonance (NMR) -derived lipoprotein particle profiles. Methods Participants were recruited from a randomized controlled trial of a dietary supplement to manage HIV-related dyslipidemia (N=132). At the initial screening visit, sociodemographic, clinical, and behavioral data were collected, and fasting peripheral venous blood specimens were obtained and lipid status was analyzed using the standard lipid panel and the NMR-derived lipoprotein particle profile. Results Using NMR-derived LDL particle cutoffs, a higher percentage of participants was outside the target range (50%) than when standard LDL cholesterol NCEP cutoffs were used (24%). Antiretroviral therapy, especially protease inhibitor-containing regimens, was associated with higher LDL particle concentration. Conclusion Substantial numbers of medically-underserved, asymptomatic HIV-infected minorities may be at increased risk for CHD based on NMR-derived lipoprotein values. PMID:20161509

  3. Modulation of expression of the nuclear receptor NR0B2 (small heterodimer partner 1) and its impact on proliferation of renal carcinoma cells

    PubMed Central

    Prestin, Katharina; Olbert, Maria; Hussner, Janine; Isenegger, Tamara L; Gliesche, Daniel G; Böttcher, Kerstin; Zimmermann, Uwe; Meyer zu Schwabedissen, Henriette E

    2016-01-01

    Mammalian nuclear receptors (NRs) are transcription factors regulating the expression of target genes that play an important role in drug metabolism, transport, and cellular signaling pathways. The orphan and structurally unique receptor small heterodimer partner 1 (syn NR0B2) is not only known for its modulation of drug response, but has also been reported to be involved in hepatocellular carcinogenesis. Indeed, previous studies show that NR0B2 is downregulated in human hepatocellular carcinoma, suggesting that NR0B2 acts as a tumor suppressor via inhibition of cellular growth and activation of apoptosis in this tumor entity. The aim of our study was to elucidate whether NR0B2 may also play a role in other tumor entities. Comparing NR0B2 expression in renal cell carcinoma and adjacent nonmalignant transformed tissue revealed significant downregulation in vivo. Additionally, the impact of heterologous expression of NR0B2 on cell cycle progression and proliferation in cells of renal origin was characterized. Monitoring fluorescence intensity of resazurin turnover in RCC-EW cells revealed no significant differences in metabolic activity in the presence of NR0B2. However, there was a significant decrease of cellular proliferation in cells overexpressing this NR, and NR0B2 was more efficient than currently used antiproliferative agents. Furthermore, flow cytometry analysis showed that heterologous overexpression of NR0B2 significantly reduced the amount of cells passing the G1 phase, while on the other hand, more cells in S/G2 phase were detected. Taken together, our data suggest that downregulation of NR0B2 may also play a role in renal cell carcinoma development and progression. PMID:27540300

  4. Modulation of expression of the nuclear receptor NR0B2 (small heterodimer partner 1) and its impact on proliferation of renal carcinoma cells.

    PubMed

    Prestin, Katharina; Olbert, Maria; Hussner, Janine; Isenegger, Tamara L; Gliesche, Daniel G; Böttcher, Kerstin; Zimmermann, Uwe; Meyer Zu Schwabedissen, Henriette E

    2016-01-01

    Mammalian nuclear receptors (NRs) are transcription factors regulating the expression of target genes that play an important role in drug metabolism, transport, and cellular signaling pathways. The orphan and structurally unique receptor small heterodimer partner 1 (syn NR0B2) is not only known for its modulation of drug response, but has also been reported to be involved in hepatocellular carcinogenesis. Indeed, previous studies show that NR0B2 is downregulated in human hepatocellular carcinoma, suggesting that NR0B2 acts as a tumor suppressor via inhibition of cellular growth and activation of apoptosis in this tumor entity. The aim of our study was to elucidate whether NR0B2 may also play a role in other tumor entities. Comparing NR0B2 expression in renal cell carcinoma and adjacent nonmalignant transformed tissue revealed significant downregulation in vivo. Additionally, the impact of heterologous expression of NR0B2 on cell cycle progression and proliferation in cells of renal origin was characterized. Monitoring fluorescence intensity of resazurin turnover in RCC-EW cells revealed no significant differences in metabolic activity in the presence of NR0B2. However, there was a significant decrease of cellular proliferation in cells overexpressing this NR, and NR0B2 was more efficient than currently used antiproliferative agents. Furthermore, flow cytometry analysis showed that heterologous overexpression of NR0B2 significantly reduced the amount of cells passing the G1 phase, while on the other hand, more cells in S/G2 phase were detected. Taken together, our data suggest that downregulation of NR0B2 may also play a role in renal cell carcinoma development and progression. PMID:27540300

  5. Miniaturized Nuclear Magnetic Resonance Platform for Detection and Profiling of Circulating Tumor Cells

    PubMed Central

    Castro, Cesar M.; Ghazani, Arezou A.; Chung, Jaehoon; Shao, Huilin; Issadore, David; Yoon, Tae-Jong; Weissleder, Ralph; Lee, Hakho

    2013-01-01

    Accurate detection and profiling of circulating tumor cells (CTCs) is a highly sought after technology to improve cancer management. Such “liquid biopsies” could offer a non-invasive, repeatable window into each patient’s tumor, facilitating early cancer diagnosis and treatment monitoring. The rarity of CTCs, approximated at 1 CTC for every billion peripheral blood cells, however, poses significant challenges to sensitive and reliable detection. We have recently developed a new biosensor platform, namely a micro-nuclear magnetic resonance (µNMR). Through the synergistic integration of microfabrication, nanosensors, and novel chemistries, the µNMR platform offers high detection sensitivity and point-of-care operation, overcoming technical barriers in CTC research. We herein review the µNMR technology with emphasis on its application on CTC detection. Recent advances in the sensing technology will be summarized, followed by the description on the dynamic interplay between preclinical and clinical CTC studies. PMID:23835814

  6. Genome-wide promoter binding profiling of protein phosphatase-1 and its major nuclear targeting subunits

    PubMed Central

    Verheyen, Toon; Görnemann, Janina; Verbinnen, Iris; Boens, Shannah; Beullens, Monique; Van Eynde, Aleyde; Bollen, Mathieu

    2015-01-01

    Protein phosphatase-1 (PP1) is a key regulator of transcription and is targeted to promoter regions via associated proteins. However, the chromatin binding sites of PP1 have never been studied in a systematic and genome-wide manner. Methylation-based DamID profiling in HeLa cells has enabled us to map hundreds of promoter binding sites of PP1 and three of its major nuclear interactors, i.e. RepoMan, NIPP1 and PNUTS. Our data reveal that the α, β and γ isoforms of PP1 largely bind to distinct subsets of promoters and can also be differentiated by their promoter binding pattern. PP1β emerged as the major promoter-associated isoform and shows an overlapping binding profile with PNUTS at dozens of active promoters. Surprisingly, most promoter binding sites of PP1 are not shared with RepoMan, NIPP1 or PNUTS, hinting at the existence of additional, largely unidentified chromatin-targeting subunits. We also found that PP1 is not required for the global chromatin targeting of RepoMan, NIPP1 and PNUTS, but alters the promoter binding specificity of NIPP1. Our data disclose an unexpected specificity and complexity in the promoter binding of PP1 isoforms and their chromatin-targeting subunits. PMID:25990731

  7. Kinetic Profile of Amyloid Formation in the Presence of an Aromatic Inhibitor by Nuclear Magnetic Resonance

    PubMed Central

    2012-01-01

    The self-assembly of amyloid proteins into β-sheet rich assemblies is associated with human amyloidoses including Alzheimer's disease, Parkinson's disease, and type 2 diabetes. An attractive therapeutic strategy therefore is to develop small molecules that would inhibit protein self-assembly. Natural polyphenols are potential inhibitors of β-sheet formation. How these compounds affect the kinetics of self-assembly studied by thioflavin T (ThT) fluorescence is not understood primarily because their presence interferes with ThT fluorescence. Here, we show that by plotting peak intensities from nuclear magnetic resonance (NMR) against incubation time, kinetic profiles in the presence of the polyphenol can be obtained from which kinetic parameters of self-assembly can be easily determined. In applying this technique to the self-assembly of the islet amyloid polypeptide in the presence of curcumin, a biphenolic compound found in turmeric, we show that the kinetic profile is atypical in that it shows a prenucleation period during which there is no observable decrease in NMR peak intensities. PMID:24900390

  8. Tissue-Specific Metabolic Profile Study of Moringa oleifera L. Using Nuclear Magnetic Resonance Spectroscopy

    PubMed Central

    Mahmud, Iqbal; Chowdhury, Kamal

    2014-01-01

    Moringa oleifera, an important multipurpose crop, is rich in various phytochemicals: flavonoids, antioxidants, vitamins, minerals and carotenes. The purpose of this study was to profile the groups of metabolites in leaf and stem tissues of M. oleifera. Various sugars, amino acids, and organic acid derivatives were found in all of the M. oleifera tissues with different profiles/peak intensities depending on the tissue. 1D proton nuclear magnetic resonance (NMR) was applied for collecting metabolite spectra. Approximately 30 metabolites with 2 unknown peaks were identified with Chenomx and verified with MMCD databases using carbon data. Among these metabolites, 22 metabolites were identified as common in both leaf and stem tissues. Of the remaining 8 metabolites, 4-aminobutyrate, adenosine, guanosine, tyrosine, and p-cresol were found only in leaf tissues; however, glutamate, glutamine, and tryptophan were found only in stem tissues. Biochemical pathway analysis revealed that 28 identified metabolites were interconnected with 36 different pathways as well as related to different fatty acids and secondary metabolites synthesis biochemical pathways. It is well known that different tissues of M. oleifera have nutritional, medicinal, and therapeutic values; therefore, our main objective is to provide a publicly available M. oliefera tissue specific metabolite database. PMID:26366209

  9. Nuclear magnetic resonance-based study reveals the metabolomics profile of nasopharyngeal carcinoma.

    PubMed

    Wang, Y; Luo, X; Zhang, G H; Li, S L

    2016-01-01

    Proton nuclear magnetic resonance ([(1)H]-NMR) spectroscopy has been used to investigate metabolites in serum and several types of tissue. We used NMR spectroscopy to explore the differential metabolic profiles in serum from nasopharyngeal carcinoma (NPC) patients. Moreover, metabolites with potential as biomarkers for identifying NPC patients were primarily identified. Serum samples were collected from 40 enrolled participants comprising 20 healthy subjects and 20 NPC patients. Samples were analyzed using a 600-MHz NMR spectrometer. The [(1)H]-NMR spectra were further analyzed with partial least squares-discriminant analysis for screening differential metabolites. NMR spectroscopy identified a total of eight metabolites that were present at different levels when the sera of NPC patients were compared with those of healthy individuals. Methionine, taurine (P < 0.05), and choline-like metabolites (P < 0.05) were mostly elevated in the sera of NPC patients. In contrast, the levels of lipids (P < 0.01), isoleucine (P < 0.05), unsaturated lipids (P < 0.01), trimethylamine oxidase (P < 0.05), and carbohydrates (P < 0.05) were lower in the sera of the NPC patients than in the healthy controls. We explored the differential metabolic profiles in sera from NPC patients. [(1)H]-NMR spectroscopy can be used to identify specific metabolites, and is capable of distinguishing between NPC patients and healthy individuals. PMID:27323073

  10. Compact Detection System for High Sensitivity Hydrogen Profiling of Materials by Nuclear Reaction Analysis

    SciTech Connect

    Marble, Daniel Keith; Urban, Ben; Pacheco, Jose

    2009-03-10

    Hydrogen is a ubiquitous contaminant that is known to have dramatic effects on the electrical, chemical, and mechanical properties of many types of materials in even minute quantities. Thus, the detection of hydrogen in materials is of major importance. Nuclear Reaction Analysis (NRA) is a powerful technique for nondestructive profiling hydrogen in materials. However, NRA has found only limited use in many applications because of poor sensitivity due to cosmic ray background (CSRB). Most attempts to eliminate CSRB to achieve ppm detection levels using higher energy nuclear reactions or tons of passive shielding are not compatible with commercial ion beam analysis space and equipment requirements Zimmerman, et al. have previously reported upon a coincidence detector that meets IBA space requirements and reduces the cosmic ray background, but the detector suffers from lower detection efficiency and small sample size. We have replaced the BGO well detector in the Zimmerman coincidence detection scheme with a larger Nal well detector and used faster timing electronics to produce a detector that can handle larger samples with higher detection efficiency, and still eliminate cosmic ray background.

  11. Unexpected Novel Relational Links Uncovered by Extensive Developmental Profiling of Nuclear Receptor Expression

    PubMed Central

    Tavares, Raquel; Sachs, Laurent; Chaumot, Arnaud; Bardet, Pierre-Luc; Escrivà, Héctor; Duffraisse, Maryline; Marchand, Oriane; Safi, Rachid; Thisse, Christine; Laudet, Vincent

    2007-01-01

    Nuclear receptors (NRs) are transcription factors that are implicated in several biological processes such as embryonic development, homeostasis, and metabolic diseases. To study the role of NRs in development, it is critically important to know when and where individual genes are expressed. Although systematic expression studies using reverse transcriptase PCR and/or DNA microarrays have been performed in classical model systems such as Drosophila and mouse, no systematic atlas describing NR involvement during embryonic development on a global scale has been assembled. Adopting a systems biology approach, we conducted a systematic analysis of the dynamic spatiotemporal expression of all NR genes as well as their main transcriptional coregulators during zebrafish development (101 genes) using whole-mount in situ hybridization. This extensive dataset establishes overlapping expression patterns among NRs and coregulators, indicating hierarchical transcriptional networks. This complete developmental profiling provides an unprecedented examination of expression of NRs during embryogenesis, uncovering their potential function during central nervous system and retina formation. Moreover, our study reveals that tissue specificity of hormone action is conferred more by the receptors than by their coregulators. Finally, further evolutionary analyses of this global resource led us to propose that neofunctionalization of duplicated genes occurs at the levels of both protein sequence and RNA expression patterns. Altogether, this expression database of NRs provides novel routes for leading investigation into the biological function of each individual NR as well as for the study of their combinatorial regulatory circuitry within the superfamily. PMID:17997606

  12. Profiling planktonic biomass using element-specific, multicomponent nuclear magnetic resonance spectroscopy.

    PubMed

    Komatsu, Takanori; Kobayashi, Toshiya; Hatanaka, Minoru; Kikuchi, Jun

    2015-06-01

    Planktonic metabolism plays crucial roles in Earth's elemental cycles. Chemical speciation as well as elemental stoichiometry is important for advancing our understanding of planktonic roles in biogeochemical cycles. In this study, a multicomponent solid-state nuclear magnetic resonance (NMR) approach is proposed for chemical speciation of cellular components, using several advanced NMR techniques. Measurements by ssNMR were performed on (13)C and (15)N-labeled Euglena gracilis, a flagellated protist. 3D dipolar-assisted rotational resonance, double-cross-polarization (1)H-(13)C correlation spectroscopy, and (1)H-(13)C solid-state heteronuclear single quantum correlation spectroscopy successively allowed characterization of cellular components. These techniques were then applied to E. gracilis cultured in high and low ammonium media to demonstrate the power of this method for profiling and comparing cellular components. Cellular NMR spectra indicated that ammonium induced both paramylon degradation and amination. Arginine was stored as a nitrogen reserve and ammonium replaced by arginine catabolism via the arginine dihydrolase pathway. (15)N and (31)P cellular ssNMR indicated arginine and polyphosphate accumulation in E. gracilis, respectively. This chemical speciation technique will contribute to environmental research by providing detailed information on environmental chemical properties. PMID:25973714

  13. Nuclear microprobe analysis of solar proton implantation profiles in lunar rock surfaces

    NASA Technical Reports Server (NTRS)

    Stauber, M. C.; Padawer, G. M.; D'Agostino, M. D.; Kamykowski, E.; Brandt, W.; Young, D. A.

    1973-01-01

    Discussion of the results of hydrogen (proton) depth profile concentration analyses conducted on selected Apollo 16 rocks. A modeling of solar particle implantation profiles in lunar rocks is shown to trace the evolvement of these profiles under the combined influence of diffusion of atomic particles implanted in the rock, and rock surface erosion. It is also demonstrated that such diffusion may have a significant effect on the shape of the implantation profiles in certain rock materials.

  14. Protein profiles of bovine placenta derived from somatic cell nuclear transfer.

    PubMed

    Kim, Hong Rye; Kang, Jae Ku; Yoon, Jong Taek; Seong, Hwan Hoo; Jung, Jin Kwan; Lee, Hong Mie; Sik Park, Chang; Jin, Dong Il

    2005-11-01

    Practical application of animal cloning by somatic cell nuclear transfer (SCNT) has been hampered by an extremely low success rate. To address whether placental dysfunction in SCNT causes fetal loss during pregnancy, we have used a global proteomics approach using 2-DE and MS to analyze the differential protein patterns of three placentae from the afterbirth of cases of postnatal death, derived from SCNT of Korean Native cattle, and three normal placentae obtained from the afterbirth of fetuses derived from artificial insemination. Proteins within a pI range of 4.0-7.0 and 6.0-9.0 were analyzed separately by 2-DE in triplicate. A total of approximately 2000 spots were detected in placental 2-DE gels stained with CBB. In the comparison of normal and SCNT samples, 60 spots were identified as differentially expressed proteins, of which 33 spots were up-regulated proteins in SCNT placentae, while 27 spots were down-regulated proteins. Most of the proteins identified in this analysis appeared to be related with protein repair or protection, cytoskeleton, signal transduction, immune system, metabolism, extracellular matrix and remodeling, transcription regulation, cell structure or differentiation and ion transport. One of up-regulated proteins in SCNT was TIMP-2 protein known to be related to extracellular matrix and remodeling during pregnancy. Western blot analysis showed an increased level of TIMP-2 in SCNT placenta compared to normal. Our results revealed composite profiles of key proteins involved in abnormal placenta derived from SCNT, and suggested expression abnormality of these genes in SCNT placenta, resulting in fetal losses following SCNT. PMID:16196098

  15. C and N depth profiles of SiCN layers determined with nuclear reaction analyses and AES

    NASA Astrophysics Data System (ADS)

    Link, F.; Baumann, H.; Bethge, K.; Klewe-Nebenius, H.; Bruns, M.

    1998-04-01

    Si 1C xN y layers were prepared by sequential implantation of 40 keV 13C- and 50 keV 15N-ions into c-Si <1 1 1> samples near RT. The carbon and nitrogen depth distributions were measured using the resonant nuclear (p,γ) reactions 15N(p,αγ) 12C at Eres=429 keV and 13C(p,γ) 14N at Eres=1748 keV, respectively. The measured raw data of depth profiling (gamma yield versus the proton beam energy) are converted to concentration-depth profiles of the elements C, N and Si with a common depth scale by using a new developed computer algorithm. These concentration profiles are compared with those obtained with Auger Electron Spectroscopy (AES) and non-Rutherford Backscattering Spectrometry (n-RBS).

  16. An intrinsically safe facility for forefront research and training on nuclear technologies — Target profile optimization

    NASA Astrophysics Data System (ADS)

    Ciotti, Marco

    2014-04-01

    A simple 1D algorithm for a spallation target profile optimization is presented. The profile efficacy is tested considering different real particle beams profiles impinging on the target. The results are commented in terms of power non-homogeneity for unit length for different beam/profile choices, showing a non-trivial parameters selection. In details, target shaping optimization is possible knowing the beam parameters with a large benefit for surface power homogeneity, but results of the simulations show that a small increase of the beam dimension, or a beam shift with respect to the assumed one, could rapidly erase the advantages.

  17. Partners: Promoting Accessible Recreation.

    ERIC Educational Resources Information Center

    Sable, Janet; Gravink, Jill

    1995-01-01

    The Promoting Accessible Recreation through Networking, Education, Resources and Services (PARTNERS) Project, a partnership between Northeast Passage, the University of New Hampshire, and Granite State Independent Living Foundation, helps create barrier-free recreation for individuals with physical disabilities. The paper describes PARTNERS and…

  18. Mirincamycin, an old candidate for malaria combination treatment and prophylaxis in the 21st century: in vitro interaction profiles with potential partner drugs in continuous culture and field isolates

    PubMed Central

    2014-01-01

    Background Spreading resistance of Plasmodium falciparum to existing drugs calls for the search for novel anti-malarial drugs and combinations for the treatment of falciparum malaria. Methods In vitro and ex vivo investigations were conducted with fresh P. falciparum field isolates and culture-adapted P. falciparum clones to evaluate the anti-malarial potential of mirincamycin, a lincosamide, alone and in combination with tafenoquine (TQ), dihydroartemisinin (DHA), and chloroquine (CQ). All samples were tested in a histidine-rich protein 2 (HRP2) drug susceptibility assay. Results Interaction analysis showed additive to synergistic interaction profiles with these potential partner drugs, with an overall geometric mean fractional inhibitory concentration at 50% inhibition (FIC50) of 0.78, 0.80 and 0.80 for mirincamycin with TQ, DHA, and CQ, respectively. Antagonism was not found in any of the tested field isolates or clones. The strongest tendency toward synergy (i.e. the lowest FIC) was seen with a combination ratio of 1:0.27 to 1:7.2 (mean 1:2.7) for the combination with tafenoquine. The optimal combination ratios for DHA and CQ were 1:444.4 to 1:36,000 (mean 1:10,755.5) and 1:2.7 to 1:216 (mean 1:64.5), respectively. No evidence of an activity correlation (i.e. potential cross-resistance) with DHA, mefloquine, quinine or chloroquine was seen whereas a significant correlation with the activity of clindamycin and azithromycin was detected. Conclusions Mirincamycin combinations may be promising candidates for further clinical investigations in the therapy and prophylaxis of multidrug-resistant falciparum malaria or in combination with 4 or 8-aminoquinolines for the treatment and relapse prevention of vivax malaria. PMID:24916383

  19. 1H-Nuclear Magnetic Resonance-Based Plasma Metabolic Profiling of Dairy Cows with Fatty Liver

    PubMed Central

    Xu, Chuang; Sun, Ling-wei; Xia, Cheng; Zhang, Hong-you; Zheng, Jia-san; Wang, Jun-song

    2016-01-01

    Fatty liver is a common metabolic disorder of dairy cows during the transition period. Historically, the diagnosis of fatty liver has involved liver biopsy, biochemical or histological examination of liver specimens, and ultrasonographic imaging of the liver. However, more convenient and noninvasive methods would be beneficial for the diagnosis of fatty liver in dairy cows. The plasma metabolic profiles of dairy cows with fatty liver and normal (control) cows were investigated to identify new biomarkers using 1H nuclear magnetic resonance. Compared with the control group, the primary differences in the fatty liver group included increases in β-hydroxybutyric acid, acetone, glycine, valine, trimethylamine-N-oxide, citrulline, and isobutyrate, and decreases in alanine, asparagine, glucose, γ-aminobutyric acid glycerol, and creatinine. This analysis revealed a global profile of endogenous metabolites, which may present potential biomarkers for the diagnosis of fatty liver in dairy cows. PMID:26732447

  20. (1)H-Nuclear Magnetic Resonance-Based Plasma Metabolic Profiling of Dairy Cows with Fatty Liver.

    PubMed

    Xu, Chuang; Sun, Ling-Wei; Xia, Cheng; Zhang, Hong-You; Zheng, Jia-San; Wang, Jun-Song

    2016-02-01

    Fatty liver is a common metabolic disorder of dairy cows during the transition period. Historically, the diagnosis of fatty liver has involved liver biopsy, biochemical or histological examination of liver specimens, and ultrasonographic imaging of the liver. However, more convenient and noninvasive methods would be beneficial for the diagnosis of fatty liver in dairy cows. The plasma metabolic profiles of dairy cows with fatty liver and normal (control) cows were investigated to identify new biomarkers using (1)H nuclear magnetic resonance. Compared with the control group, the primary differences in the fatty liver group included increases in β-hydroxybutyric acid, acetone, glycine, valine, trimethylamine-N-oxide, citrulline, and isobutyrate, and decreases in alanine, asparagine, glucose, γ-aminobutyric acid glycerol, and creatinine. This analysis revealed a global profile of endogenous metabolites, which may present potential biomarkers for the diagnosis of fatty liver in dairy cows. PMID:26732447

  1. Nuclear localization and molecular partners of BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors.

    PubMed

    Padilla, Philip Ian; Pacheco-Rodriguez, Gustavo; Moss, Joel; Vaughan, Martha

    2004-03-01

    Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) is an approximately 200-kDa brefeldin A-inhibited guanine nucleotide-exchange protein that preferentially activates ADP-ribosylation factor 1 (ARF1) and ARF3. BIG1 was found in cytosol in a multiprotein complex with a similar ARF-activating protein, BIG2, which is also an A kinase-anchoring protein. In HepG2 cells growing with serum, BIG1 was primarily cytosolic and Golgi-associated. After incubation overnight without serum, a large fraction of endogenous BIG1 was in the nuclei. By confocal immunofluorescence microscopy, BIG1 was localized with nucleoporin p62 at the nuclear envelope (probably during nucleocytoplasmic transport) and also in nucleoli, clearly visible against the less concentrated overall matrix staining. BIG1 was also identified by Western blot analyses in purified subnuclear fractions (e.g., nucleoli and nuclear matrix). Antibodies against BIG1, nucleoporin, or nucleolin coimmunoprecipitated the other two proteins from purified nuclei. In contrast, BIG2 was not associated with nuclear BIG1. Also of note, ARF was never detected among proteins precipitated from purified nuclei by anti-BIG1 antibodies, although microscopically the two proteins do appear sometimes to be colocalized in the nucleus. These data are consistent with independent intracellular movements and actions of BIG1 and BIG2, and they are also evidence of the participation of BIG1 in both Golgi and nuclear functions. PMID:14973189

  2. {beta}-Catenin can act as a nuclear import receptor for its partner transcription factor, lymphocyte enhancer factor-1 (lef-1)

    SciTech Connect

    Asally, Munehiro; Yoneda, Yoshihiro . E-mail: yyoneda@anat3.med.osaka-u.ac.jp

    2005-08-15

    Nuclear accumulation of {beta}-catenin plays an important role in the Wnt signaling pathway. In the nucleus, {beta}-catenin acts as a transcriptional co-activator for TCF/LEF family of transcription factors. It has been shown that lef-1 contains a typical basic type nuclear localization signal (NLS) and is transported into the nucleus by the conventional import pathway. In this study, we found that a mutant lef-1 lacking the classical NLS accumulated in the nucleus of living cells, when {beta}-catenin was co-expressed. In addition, in a cell-free import assay, lef-1 migrated into the nucleus in the presence of {beta}-catenin alone without any other soluble factors. In contrast, another mutant lef-1 lacking the {beta}-catenin binding domain failed to migrate into the nucleus, even in the presence of {beta}-catenin. These findings indicate that {beta}-catenin alone can mediate the nuclear import of lef-1 through the direct binding. Collectively, we propose that there are two distinct pathways for the nuclear import of lef-1: importin {alpha}/{beta}-mediated and {beta}-catenin-mediated one, which provides a novel paradigm for Wnt signaling pathway.

  3. Profiles of embryonic nuclear protein binding to the proximal promoter region of the soybean β-conglycinin α subunit gene.

    PubMed

    Yoshino, M; Tsutsumi, K; Kanazawa, A

    2015-01-01

    β-Conglycinin, a major component of seed storage protein in soybean, comprises three subunits: α, α' and β. The expression of genes for these subunits is strictly controlled during embryogenesis. The proximal promoter region up to 245 bp upstream of the transcription start site of the α subunit gene sufficiently confers spatial and temporal control of transcription in embryos. Here, the binding profile of nuclear proteins in the proximal promoter region of the α subunit gene was analysed. DNase I footprinting analysis indicated binding of proteins to the RY element and DNA regions including box I, a region conserved in cognate gene promoters. An electrophoretic mobility shift assay (EMSA) using different portions of box I as a probe revealed that multiple portions of box I bind to nuclear proteins. In addition, an EMSA using nuclear proteins extracted from embryos at different developmental stages indicated that the levels of major DNA-protein complexes on box I increased during embryo maturation. These results are consistent with the notion that box I is important for the transcriptional control of seed storage protein genes. Furthermore, the present data suggest that nuclear proteins bind to novel motifs in box I including 5'-TCAATT-3' rather than to predicted cis-regulatory elements. PMID:24943483

  4. Resources for Partners

    SciTech Connect

    2006-02-01

    This DOE Industrial Technologies Program fact sheet describes the resources and opportunities available to partners how manufacturing plants can save energy and money by making energy efficiency improvements to their industrial process heating systems.

  5. Partnering for the Future

    NASA Video Gallery

    With an ambitious new direction and a new way of doing business, NASA's Kennedy Space Center is embracing a new relationship with the commercial space industry and other partners to build a multi-u...

  6. In situ effective diffusion coefficient profiles in live biofilms using pulsed-field gradient nuclear magnetic resonance

    PubMed Central

    Renslow, Ryan S.; Majors, Paul D.; McLean, Jeffrey S.; Fredrickson, Jim K.; Ahmed, Bulbul; Beyenal, Haluk

    2010-01-01

    Diffusive mass transfer in biofilms is characterized by the effective diffusion coefficient. It is well-documented that the effective diffusion coefficient can vary by location in a biofilm. The current literature is dominated by effective diffusion coefficient measurements for distinct cell clusters and stratified biofilms showing this spatial variation. Regardless of whether distinct cell clusters or surface-averaging methods are used, position-dependent measurements of the effective diffusion coefficient are currently: 1) invasive to the biofilm, 2) performed under unnatural conditions, 3) lethal to cells, and/or 4) spatially restricted to only certain regions of the biofilm. Invasive measurements can lead to inaccurate results and prohibit further (time-dependent) measurements which are important for the mathematical modeling of biofilms. In this study our goals were to: 1) measure the effective diffusion coefficient for water in live biofilms, 2) monitor how the effective diffusion coefficient changes over time under growth conditions, and 3) correlate the effective diffusion coefficient with depth in the biofilm. We measured in situ two-dimensional effective diffusion coefficient maps within Shewanella oneidensis MR-1 biofilms using pulsed-field gradient nuclear magnetic resonance methods, and used them to calculate surface-averaged relative effective diffusion coefficient (Drs) profiles. We found that 1) Drs decreased from the top of the biofilm to the bottom, 2) Drs profiles differed for biofilms of different ages, 3) Drs profiles changed over time and generally decreased with time, 4) all the biofilms showed very similar Drs profiles near the top of the biofilm, and 5) the Drs profile near the bottom of the biofilm was different for each biofilm. Practically, our results demonstrate that advanced biofilm models should use a variable effective diffusivity which changes with time and location in the biofilm. PMID:20589671

  7. In Situ Effective Diffusion Coefficient Profiles in Live Biofilms Using Pulsed-Field Gradient Nuclear Magnetic Resonance

    SciTech Connect

    Renslow, Ryan S.; Majors, Paul D.; McLean, Jeffrey S.; Fredrickson, Jim K.; Ahmed, B.; Beyenal, Haluk

    2010-08-15

    Diffusive mass transfer in biofilms is characterized by the effective diffusion coefficient. It is well-documented that the effective diffusion coefficient can vary by location in a biofilm. The current literature is dominated by effective diffusion coefficient measurements for distinct cell clusters and stratified biofilms showing this spatial variation. Regardless of whether distinct cell clusters or surface-averaging methods are used, position-dependent measurements of the effective diffusion coefficient are currently: 1) invasive to the biofilm, 2) performed under unnatural conditions, 3) lethal to cells, and/or 4) spatially restricted to only certain regions of the biofilm. Invasive measurements can lead to inaccurate results and prohibit further (time dependent) measurements which are important for the mathematical modeling of biofilms. In this study our goals were to: 1) measure the effective diffusion coefficient for water in live biofilms, 2) monitor how the effective diffusion coefficient changes over time under growth conditions, and 3) correlate the effective diffusion coefficient with depth in the biofilm. We measured in situ two-dimensional effective diffusion coefficient maps within Shewanella oneidensis MR-1biofilms using pulsed-field gradient nuclear magnetic resonance methods, and used them to calculate surface-averaged relative effective diffusion coefficient (Drs) profiles. We found that 1) Drs decreased from the top of the biofilm to the bottom, 2) Drs profiles differed for biofilms of different ages, 3) Drs profiles changed over time and generally decreased with time, 4) all the biofilms showed very similar Drs profiles near the top of the biofilm, and 5) the Drs profile near the bottom of the biofilm was different for each biofilm. Practically, our results demonstrate that advanced biofilm models should use a variable effective diffusivity which changes with time and location in the biofilm.

  8. Nuclear Magnetic Resonance (NMR) Spectroscopy For Metabolic Profiling of Medicinal Plants and Their Products.

    PubMed

    Kumar, Dinesh

    2016-09-01

    NMR spectroscopy has multidisciplinary applications, including excellent impact in metabolomics. The analytical capacity of NMR spectroscopy provides information for easy qualitative and quantitative assessment of both endogenous and exogenous metabolites present in biological samples. The complexity of a particular metabolite and its contribution in a biological system are critically important for understanding the functional state that governs the organism's phenotypes. This review covers historical aspects of developments in the NMR field, its applications in chemical profiling, metabolomics, and quality control of plants and their derived medicines, foods, and other products. The bottlenecks of NMR in metabolic profiling are also discussed, keeping in view the future scope and further technological interventions. PMID:26575437

  9. Absolute hydrogen depth profiling using the resonant 1H(15N, αγ)12C nuclear reaction

    NASA Astrophysics Data System (ADS)

    Reinhardt, Tobias P.; Akhmadaliev, Shavkat; Bemmerer, Daniel; Stöckel, Klaus; Wagner, Louis

    2016-08-01

    Resonant nuclear reactions are a powerful tool for the determination of the amount and profile of hydrogen in thin layers of material. Usually, this tool requires the use of a standard of well-known composition. The present work, by contrast, deals with standard-less hydrogen depth profiling. This approach requires precise nuclear data, e.g. on the widely used 1 H(15 N, αγ)12 C reaction, resonant at 6.4 MeV 15 N beam energy. Here, the strongly anisotropic angular distribution of the emitted γ -rays from this resonance has been re-measured, resolving a previous discrepancy. Coefficients of (0.38 ± 0.04) and (0.80 ± 0.04) have been deduced for the second and fourth order Legendre polynomials, respectively. In addition, the resonance strength has been re-evaluated to (25.0 ± 1.5) eV, 10% higher than previously reported. A simple working formula for the hydrogen concentration is given for cases with known γ -ray detection efficiency. Finally, the absolute approach is illustrated using two examples.

  10. Specificity of antinuclear autoantibodies recognizing the dense fine speckled nuclear pattern: Preferential targeting of DFS70/LEDGFp75 over its interacting partner MeCP2.

    PubMed

    Basu, Anamika; Woods-Burnham, Leanne; Ortiz, Greisha; Rios-Colon, Leslimar; Figueroa, Johnny; Albesa, Roger; Andrade, Luis E; Mahler, Michael; Casiano, Carlos A

    2015-12-01

    Human antinuclear autoantibodies (ANAs) targeting the dense fine speckled (DFS) nuclear protein DFS70, commonly known as lens epithelium derived growth factor p75 (LEDGFp75), present a clinical puzzle since their significance remains elusive. While their frequencies are low in ANA-positive autoimmune rheumatic diseases, they are relatively elevated in clinical laboratory referrals, diverse inflammatory conditions, and 'apparently' healthy individuals. We reported previously that DFS70/LEDGFp75 is an autoantigen in prostate cancer that closely interacts with another 70kD DFS nuclear protein, methyl CpG binding protein 2 (MeCP2). This led us to investigate if anti-DFS sera exclusively target DFS70/LEDGFp75 or also recognize MeCP2. Using several complementary autoantibody detection platforms and cellular/molecular approaches we evaluated 65 human sera producing anti-DFS autoantibodies. Our results show that these antibodies are highly specific for DFS70/LEDGFp75 and do not target MeCP2. Establishing the specificity of anti-DFS autoantibodies has implications for increasing our understanding of their biological significance and clinical utility. PMID:26235378

  11. Protein profiles in cortical and nuclear regions of aged human donor lenses: A confocal Raman microspectroscopic and imaging study.

    PubMed

    Vrensen, Gijs F J M; Otto, Cees; Lenferink, Aufried; Liszka, Barbara; Montenegro, Gustavo A; Barraquer, Rafael I; Michael, Ralph

    2016-04-01

    A combination of Raman spectroscopy, imaging, hierarchical cluster analysis (HCA) and peak ratio analysis was used to analyze protein profiles in the superficial cortex (SC), deep cortex (DC) and nucleus of old human lenses with cortical, nuclear and mixed cataracts. No consistent differences were observed in protein spectra and after cluster analysis between the three locations irrespective of the presence or absence of cortical opacities and/or coloration. A sharp increase (∼15%-∼33%) in protein content from SC to DC, normal for human lenses, was found in 7 lenses. In 4 lenses, characterized by the absence of cortical opacities, the SC has a protein content of ∼35%. A significant increase in the disulfide-to-protein ratio is found only in the SC of the 7 cortical cataracts. No changes were found in sulfhydryl-to-protein ratio. The relative contents of α-helices and β-sheets increase from SC to nucleus. β-Sheets are more common in the SC of lenses with cortical cataract. The absence of significant and consistent changes in protein profiles between nucleus and cortex even in cases of severe coloration is not favoring the prevailing concept that ubiquitous protein oxidation is a key factor for age related nuclear (ARN) cataracts. The observations favor the idea that multilamellar bodies or protein aggregates at very low volume densities are responsible for the rise in Mie light scatter as a main cause of ARN cataracts leaving the short-range-order of the fiber cytoplasm largely intact. The absence of significant changes in the protein spectra of the deep cortical opacities, milky white as a result of the presence of vesicle-like features, indicate they are packed with relatively undisturbed crystallins. PMID:26611157

  12. Partnering with Homeschoolers.

    ERIC Educational Resources Information Center

    Caruana, Vicki

    1999-01-01

    Homeschooled students from families representing all ethnicities, socioeconomic backgrounds, and education levels are increasingly entering public schools part-time. This article explains how school administrators, teachers, parents, and homeschoolers can become partners. Tips are provided on classroom deportment, parental aspirations, and…

  13. Intimate partner violence.

    PubMed

    Pibernat, Artur Dalfó

    2016-05-01

    IT IS with great interest that I read the article 'Identifying signs of intimate partner violence' (Art & science) by Ali et al in February's issue of Emergency Nurse. The issue has been widely recognised as one which needs promoting among adolescents in schools and in nurse education. PMID:27165383

  14. Partners of the Community.

    ERIC Educational Resources Information Center

    Reese, Susan

    2002-01-01

    Oklahoma has a long tradition of partnering with the community and its career-tech system is viewed as the economic development arm of the Oklahoma Public School system. A partnership between the Tri County Technology Center and University of Oklahoma, for example, involves dental hygiene students in providing oral health care for poor rural…

  15. Collaboration with Community Partners

    ERIC Educational Resources Information Center

    Sterling, Donna R.; Frazier, Wendy M.

    2006-01-01

    For eight years, relationships with community partners have been the mainstay of a science enrichment program for secondary students. Through the use of problem-based learning, science classes use, the techniques and tools of scientists to solve authentic problems directly related to students' interests and needs. In this article, the author…

  16. The Partners Program.

    ERIC Educational Resources Information Center

    Raughton, Jim L.

    In response to alarming drop-out rates among high school students and indications that the emerging workforce will be predominantly minority and disadvantaged, the Colorado Community College and Occupational Education System (CCCOES) developed the Partners program to encourage minority students from as early as seventh grade to remain and succeed…

  17. Nuclear factor 45 of half smooth tongue sole Cynoglossus semilaevis: gene structure, expression profile, and immunoregulatory property.

    PubMed

    Chi, Heng; Xiao, Zhi-zhong; Sun, Li

    2013-09-01

    Nuclear factor 45 (NF45) is a component of the protein complex called nuclear factor of activated T-cells (NFAT), which in mammals regulates interleukin (IL)-2 expression. To date very little is known about fish NF45. In this study, we identified a NF45 (named CsNF45) from half smooth tongue sole Cynoglossus semilaevis and examined its gene organization, expression profile, and regulatory function. We found that CsNF45 is composed of 387 residues and shares 90.3%-97.9% overall sequence identities with the NF45 of human and teleosts. Genetic analysis showed that the genomic sequence of the ORF region of CsNF45 consists of 14 exons and 13 introns. Constitutive expression of CsNF45 occurred in multiple tissues including gill, muscle, brain, heart, liver, head kidney, spleen, and gut. Experimental infection with viral and bacterial pathogens upregulated the expression of CsNF45 in head kidney and spleen in a time-dependent manner. Transient transfection analysis showed that CsNF45 was localized in the nucleus and able to stimulate the activity of mouse IL-2 promoter. These results indicate that CsNF45 possesses immunoregulatory property and is possibly involved in host immune defense against bacterial and viral infection. PMID:23872474

  18. Predictability of Conversation Partners

    NASA Astrophysics Data System (ADS)

    Takaguchi, Taro; Nakamura, Mitsuhiro; Sato, Nobuo; Yano, Kazuo; Masuda, Naoki

    2011-08-01

    Recent developments in sensing technologies have enabled us to examine the nature of human social behavior in greater detail. By applying an information-theoretic method to the spatiotemporal data of cell-phone locations, [C. Song , ScienceSCIEAS0036-8075 327, 1018 (2010)] found that human mobility patterns are remarkably predictable. Inspired by their work, we address a similar predictability question in a different kind of human social activity: conversation events. The predictability in the sequence of one’s conversation partners is defined as the degree to which one’s next conversation partner can be predicted given the current partner. We quantify this predictability by using the mutual information. We examine the predictability of conversation events for each individual using the longitudinal data of face-to-face interactions collected from two company offices in Japan. Each subject wears a name tag equipped with an infrared sensor node, and conversation events are marked when signals are exchanged between sensor nodes in close proximity. We find that the conversation events are predictable to a certain extent; knowing the current partner decreases the uncertainty about the next partner by 28.4% on average. Much of the predictability is explained by long-tailed distributions of interevent intervals. However, a predictability also exists in the data, apart from the contribution of their long-tailed nature. In addition, an individual’s predictability is correlated with the position of the individual in the static social network derived from the data. Individuals confined in a community—in the sense of an abundance of surrounding triangles—tend to have low predictability, and those bridging different communities tend to have high predictability.

  19. Partner Facilitation and Partner Interference in Individuals' Weight Loss Goals.

    PubMed

    Theiss, Jennifer A; Carpenter, Amanda M; Leustek, John

    2016-08-01

    Drawing on the logic of the relational turbulence model, this study examined the ways in which romantic partners facilitate and interfere with individuals' weight loss goals. Participants (N = 122) described the ways in which their romantic partner had recently helped or hindered their weight loss at four times over the course of 2 months. We conducted a content analysis of responses to identify themes of partner facilitation (Research Question 1 [RQ1]) and partner interference (RQ2) in individuals' weight loss goals. Results revealed seven themes of partner facilitation: (a) partner enabling diet, (b) motivation and encouragement, (c) emotional support and positive reinforcement, (d) exercising together, (e) partner enabling exercise, (f) dieting together, and (g) relationship influence and priorities. Four themes of partner interference emerged in the data: (a) inability to plan for healthy meals, (b) inability to control the food environment, (c) preventing or discouraging exercise, and (d) emotional or relational discouragement. PMID:25904678

  20. Parents as Writing Partners

    ERIC Educational Resources Information Center

    Ehrenworth, Mary

    2014-01-01

    Parents know that writing is essential to their children's success, and they're eager to help their children become good writers. But often, they're at a loss about how to help. Instead of leaving them in the dark, schools can make parents into valuable writing partners by giving them a toolkit of guidelines for coaching writers.…

  1. Nuclear Microprobe using Elastic Recoil Detection (ERD) for Hydrogen Profiling in High Temperature Protonic Conductors

    NASA Technical Reports Server (NTRS)

    Berger, Pascal; Sayir, Ali; Berger, Marie-Helene

    2004-01-01

    The interaction between hydrogen and various high temperature protonic conductors (HTPC) has not been clearly understood due to poor densification and unreacted secondary phases. the melt-processing technique is used in producing fully dense simple SrCe(0.9)Y (0.10) O(3-delta) and complex Sr3Ca(1+x)Nb(2+x)O(9-delta) perovskites that can not be achieved by solid-state sintering. the possibilities of ion beam analysis have been investigated to quantify hydrogen distribution in HTPC perovskites subjected to water heat treatment. Nuclear microprobe technique is based on the interactions of a focused ion beam of MeV light ions (H-1, H-2, He-3, He-4,.) with the sample to be analyzed to determine local elemental concentrations at the cubic micrometer scale, the elastic recoil detection analysis technique (ERDA) has been carried out using He-4(+) microbeams and detecting the resulting recoil protons. Mappings of longitudinal sections of water treated SrCeO3 and Sr(Ca(1/3)Nb(2/3))O3 perovskites have been achieved, the water treatment strongly alters the surface of simple SrCe(0.9)Y(0.10)O(3-delta) perovskite. From Rutherford Back Scattering measurements (RBS), both Ce depletion and surface re-deposition is evidenced. the ERDA investigations on water treated Sr3Ca(1+x)Nb(2+x)O(9-delta) perovskite did not exhibit any spatial difference for the hydrogen incorporation from the surface to the centre. the amount of hydrogen incorporation for Sr3Ca(1+x)Nb(2+x)O(9-delta) was low and required further development of two less conventional techniques, ERDA in forward geometry and forward elastic diffusion H-1(p,p) H-1 with coincidence detection.

  2. Metabolic profiling of a Schistosoma mansoni infection in mouse tissues using magic angle spinning-nuclear magnetic resonance spectroscopy.

    PubMed

    Li, Jia V; Holmes, Elaine; Saric, Jasmina; Keiser, Jennifer; Dirnhofer, Stephan; Utzinger, Jürg; Wang, Yulan

    2009-04-01

    In order to enhance our understanding of physiological and pathological consequences of a patent Schistosoma mansoni infection in the mouse, we examined the metabolic responses of different tissue samples recovered from the host animal using a metabolic profiling strategy. Ten female NMRI mice were infected with approximately 80 S. mansoni cercariae each, and 10 uninfected age- and sex-matched animals served as controls. At day 74 post infection (p.i.), mice were killed and jejunum, ileum, colon, liver, spleen and kidney samples were removed. We employed (1)H magic angle spinning-nuclear magnetic resonance spectroscopy to generate tissue-specific metabolic profiles. The spectral data were analyzed using multivariate modelling methods including an orthogonal signal corrected-projection to latent structure analysis and hierarchical principal component analysis to assess the differences and/or similarities in metabolic responses between infected and non-infected control mice. Most tissues obtained from S. mansoni-infected mice were characterized by high levels of amino acids, such as leucine, isoleucine, lysine, glutamine and asparagine. High levels of membrane phospholipid metabolites, including glycerophosphoryl choline and phosphoryl choline were found in the ileum, colon, liver and spleen of infected mice. Additionally, low levels of energy-related metabolites, including lipids, glucose and glycogen were observed in ileum, spleen and liver samples of infected mice. Energy-related metabolites in the jejunum, liver and renal medulla were found to be positively correlated with S. mansoni worm burden upon dissection. These findings show that a patent S. mansoni infection causes clear disruption of metabolism in a range of tissues at a molecular level, which can be interpreted in relation to the previously reported signature in a biofluid (i.e. urine), giving further evidence of the global effect of the infection. PMID:19068218

  3. Interaction Quality during Partner Reading

    PubMed Central

    Meisinger, Elizabeth B.; Schwanenflugel, Paula J.; Bradley, Barbara A.; Stahl, Steven A.

    2009-01-01

    The influence of social relationships, positive interdependence, and teacher structure on the quality of partner reading interactions was examined. Partner reading, a scripted cooperative learning strategy, is often used in classrooms to promote the development of fluent and automatic reading skills. Forty-three pairs of second grade children were observed during partner reading sessions taking place in 12 classrooms. The degree to which the partners displayed social cooperation (instrumental support, emotional support, and conflict management) and on/off task behavior was evaluated. Children who chose their own partners showed greater social cooperation than those children whose teacher selected their partner. However, when the positive interdependence requirements of the task were not met within the pair (neither child had the skills to provide reading support or no one needed support), lower levels of on-task behavior were observed. Providing basic partner reading script instruction at the beginning of the year was associated with better social cooperation during partner reading, but providing elaborated instruction or no instruction was associated with poorer social cooperation. It is recommended that teachers provide basic script instruction and allow children to choose their own partners. Additionally, pairings of low ability children with other low ability children and high ability children with other high ability children should be avoided. Teachers may want to suggest alternate partners for children who inadvertently choose such pairings or adjust the text difficulty to the pair. Overall, partner reading seems to be an enjoyable pedagogical strategy for teaching reading fluency. PMID:19830259

  4. Identification of 1- and 3-methylhistidine as biomarkers of skeletal muscle toxicity by nuclear magnetic resonance-based metabolic profiling.

    PubMed

    Aranibar, Nelly; Vassallo, Jeffrey D; Rathmacher, John; Stryker, Steve; Zhang, Yingru; Dai, Jun; Janovitz, Evan B; Robertson, Don; Reily, Michael; Lowe-Krentz, Linda; Lehman-McKeeman, Lois

    2011-03-01

    Nuclear magnetic resonance (NMR)-based metabolomic profiling identified urinary 1- and 3-methylhistidine (1- and 3-MH) as potential biomarkers of skeletal muscle toxicity in Sprague-Dawley rats following 7 and 14 daily doses of 0.5 or 1mg/kg cerivastatin. These metabolites were highly correlated to sex-, dose- and time-dependent development of cerivastatin-induced myotoxicity. Subsequently, the distribution and concentration of 1- and 3-MH were quantified in 18 tissues by gas chromatography-mass spectrometry. The methylhistidine isomers were most abundant in skeletal muscle with no fiber or sex differences observed; however, 3-MH was also present in cardiac and smooth muscle. In a second study, rats receiving 14 daily doses of 1mg/kg cerivastatin (a myotoxic dose) had 6- and 2-fold elevations in 1- and 3-MH in urine and had 11- and 3-fold increases in 1- and 3-MH in serum, respectively. Selectivity of these potential biomarkers was tested by dosing rats with the cardiotoxicant isoproterenol (0.5mg/kg), and a 2-fold decrease in urinary 1- and 3-MH was observed and attributed to the anabolic effect on skeletal muscle. These findings indicate that 1- and 3-MH may be useful urine and serum biomarkers of drug-induced skeletal muscle toxicity and hypertrophy in the rat, and further investigation into their use and limitations is warranted. PMID:21094120

  5. FEAR OF PAST ABUSIVE PARTNER(S) IMPACTS CURRENT POSTTRAUMATIC STRESS AMONG WOMEN EXPERIENCING PARTNER VIOLENCE

    PubMed Central

    Jaquier, Véronique; Sullivan, Tami P.

    2014-01-01

    This study examines the impact of fear of past abusive partner(s) on posttraumatic stress among 212 community-recruited women currently exposed to intimate partner violence (IPV). The path analysis model tested explained 60% of the variation in IPV-related posttraumatic stress. Findings revealed that fear of past abusive partner(s) was uniquely associated with the severity of current posttraumatic stress symptoms over and above the impact of current IPV or childhood abuse and neglect. Future research should continue examining women's subjective emotional experience of past and current victimization so as to further inform both clinical practice and intervention planning. PMID:24590514

  6. Classifying partner femicide.

    PubMed

    Dixon, Louise; Hamilton-Giachritsis, Catherine; Browne, Kevin

    2008-01-01

    The heterogeneity of domestic violent men has long been established. However, research has failed to examine this phenomenon among men committing the most severe form of domestic violence. This study aims to use a multidimensional approach to empirically construct a classification system of men who are incarcerated for the murder of their female partner based on the Holtzworth-Munroe and Stuart (1994) typology. Ninety men who had been convicted and imprisoned for the murder of their female partner or spouse in England were identified from two prison samples. A content dictionary defining offense and offender characteristics associated with two dimensions of psychopathology and criminality was developed. These variables were extracted from institutional records via content analysis and analyzed for thematic structure using multidimensional scaling procedures. The resultant framework classified 80% (n = 72) of the sample into three subgroups of men characterized by (a) low criminality/low psychopathology (15%), (b) moderate-high criminality/ high psychopathology (36%), and (c) high criminality/low-moderate psychopathology (49%). The latter two groups are akin to Holtzworth-Munroe and Stuart's (1994) generally violent/antisocial and dysphoric/borderline offender, respectively. The implications for intervention, developing consensus in research methodology across the field, and examining typologies of domestic violent men prospectively are discussed. PMID:18087033

  7. Depth distribution of 137Cs, 134Cs, and 131I in soil profile after Fukushima Dai-ichi Nuclear Power Plant Accident.

    PubMed

    Kato, Hiroaki; Onda, Yuichi; Teramage, Mengistu

    2012-09-01

    Soil, vegetation and other ecological compartments are expected to be highly contaminated by the deposited radionuclides after the Fukushima Dai-ichi Nuclear Power Plant (FDNPP) accident triggered by a magnitude 9.0 earthquake and the resulting tsunami on 11 March 2011. However, there is no field measurement data on the depth distributions of radiocaesium and (131)I concentrations in soil profile. In this study, the depth distribution of the deposited radionuclides in the cultivated soil profile was investigated in one of the most contaminated area after FDNPP accident. The result of this study demonstrated that greater than 86% of total radiocaesium and 79% of total (131)I were absorbed in the upper 2.0 cm in the soil profile. The relaxation mass depth (h(0)) derived from the depth distribution of radiocaesium and (131)I in the soil profile at the study site were 9.1 kg m(-2) and 10.4 kg m(-2), respectively. The h(0) of (137)Cs in the studied soil profile was greater than those for the cultivated soils nearby the Chernobyl NPP. The positive relationship was found between clay content of topsoil and the h(0) of (137)Cs. However, further analysis is required to clarify the effect of clay content on the initial penetration depth of deposited (137)Cs in soil profile. PMID:22029969

  8. Partnering for success.

    PubMed

    Gookin, L B

    1996-01-01

    Almost every health care journal or newsletter I pick up has at least one article about the changes occurring in the health care delivery system. The changes for providers in all settings are enormous as we downsize, rightsize, merge, or simply change to meet the demands of managed care. The bottom line is that hospitals are shrinking and health care is moving into the outpatient and community environment. Those of us who are providers in any of these settings must respond rapidly to the changes, which are having a profound impact on the practice of nursing today that will continue into the future. Are nursing educators prepared to respond as quickly as providers to the environmental changes, and are they prepared to make the necessary curriculum changes to prepare students for their future profession? It seems more critical than ever for providers and educators to partner to successfully meet the current and future demands of the nursing profession. PMID:9157919

  9. Metabolic profiles using (1)H-nuclear magnetic resonance spectroscopy in postpartum dairy cows with ovarian inactivity.

    PubMed

    Xu, Chuchu; Xia, Cheng; Sun, Yuhang; Xiao, Xinhuan; Wang, Gang; Fan, Ziling; Shu, Shi; Zhang, Hongyou; Xu, Chuang; Yang, Wei

    2016-10-01

    To understand the differences in metabolic changes between cows with ovarian inactivity and estrus cows, we selected cows at 60-90 days postpartum from an intensive dairy farm. According to clinical manifestations, B-ultrasound scan, rectal examination, 10 cows were assigned to the estrus group (A) and 10 to the ovarian inactivity group (B). All plasma samples were analyzed by (1)H-nuclear magnetic resonance spectroscopy to compare plasma metabolomic profiles between the groups. We used multivariate pattern recognition to screen for different metabolites in plasma of anestrus cows. Compared with normal estrous cows, there were abnormalities in 12 kinds of metabolites in postpartum cows with ovarian inactivity (|r|> 0.602), including an increase in acetic acid (r = -0.817), citric acid (r = -0.767), and tyrosine (r = -0.714), and a decrease in low-density lipoprotein (r = 0.820), very low-density lipoprotein (r = 0.828), lipids (r = 0.769), alanine (r = 0.816), pyruvate (r = 0.721), creatine (r = 0.801), choline (r = 0.639), phosphorylcholine (r = 0.741), and glycerophosphorylcholine (r = 0.881). These metabolites were closely related to abnormality of glucose, amino acid, lipoprotein and choline metabolism, which may disturb the normal estrus. The decrease in plasma creatine and the increase in tyrosine were new changes for ovarian inactivity of postpartum cows. The decrease in plasma creatine and choline and the increase in tyrosine and p-hydroxyphenylalanine in cows with ovarian inactivity provide new directions for research on the mechanism of ovarian inactivity in cows. PMID:27291083

  10. A phytochemical comparison of saw palmetto products using gas chromatography and 1H nuclear magnetic resonance spectroscopy metabolomic profiling

    PubMed Central

    Booker, Anthony; Suter, Andy; Krnjic, Ana; Strassel, Brigitte; Zloh, Mire; Said, Mazlina; Heinrich, Michael

    2014-01-01

    Objectives Preparations containing saw palmetto berries are used in the treatment of benign prostatic hyperplasia (BPH). There are many products on the market, and relatively little is known about their chemical variability and specifically the composition and quality of different saw palmetto products notwithstanding that in 2000, an international consultation paper from the major urological associations from the five continents on treatments for BPH demanded further research on this topic. Here, we compare two analytical approaches and characterise 57 different saw palmetto products. Methods An established method – gas chromatography – was used for the quantification of nine fatty acids, while a novel approach of metabolomic profiling using 1H nuclear magnetic resonance (NMR) spectroscopy was used as a fingerprinting tool to assess the overall composition of the extracts. Key findings The phytochemical analysis determining the fatty acids showed a high level of heterogeneity of the different products in the total amount and of nine single fatty acids. A robust and reproducible 1H NMR spectroscopy method was established, and the results showed that it was possible to statistically differentiate between saw palmetto products that had been extracted under different conditions but not between products that used a similar extraction method. Principal component analysis was able to determine those products that had significantly different metabolites. Conclusions The metabolomic approach developed offers novel opportunities for quality control along the value chain of saw palmetto and needs to be followed further, as with this method, the complexity of a herbal extract can be better assessed than with the analysis of a single group of constituents. PMID:24417505

  11. Computer program TRACK_TEST for calculating parameters and plotting profiles for etch pits in nuclear track materials

    NASA Astrophysics Data System (ADS)

    Nikezic, D.; Yu, K. N.

    2006-01-01

    A computer program called TRACK_TEST for calculating parameters (lengths of the major and minor axes) and plotting profiles in nuclear track materials resulted from light-ion irradiation and subsequent chemical etching is described. The programming steps are outlined, including calculations of alpha-particle ranges, determination of the distance along the particle trajectory penetrated by the chemical etchant, calculations of track coordinates, determination of the lengths of the major and minor axes and determination of the contour of the track opening. Descriptions of the program are given, including the built-in V functions for the two commonly employed nuclear track materials commercially known as LR 115 (cellulose nitrate) and CR-39 (poly allyl diglycol carbonate) irradiated by alpha particles. Program summaryTitle of the program:TRACK_TEST Catalogue identifier:ADWT Program obtainable from:CPC Program Library, Queen's University of Belfast, N. Ireland Program summary URL:http://cpc.cs.qub.ac.uk/summaries/ADWT Computer:Pentium PC Operating systems:Windows 95+ Programming language:Fortran 90 Memory required to execute with typical data:256 MB No. of lines in distributed program, including test data, etc.: 2739 No. of bytes in distributed program, including test data, etc.:204 526 Distribution format:tar.gz External subprograms used:The entire code must be linked with the MSFLIB library Nature of problem: Fast heavy charged particles (like alpha particles and other light ions etc.) create latent tracks in some dielectric materials. After chemical etching in aqueous NaOH or KOH solutions, these tracks become visible under an optical microscope. The growth of a track is based on the simultaneous actions of the etchant on undamaged regions (with the bulk etch rate V) and along the particle track (with the track etch rate V). Growth of the track is described satisfactorily by these two parameters ( V and V). Several models have been presented in the past describing

  12. WASPs (Wives As Senior Partners).

    ERIC Educational Resources Information Center

    Atkinson, Maxine P.; Boles, Jacqueline

    For the past decade dual-earner marriages in which wives are junior partners have been a major topic in marriage and family literature. In marriages which consider wives as senior partners (WASPs), however, the wife's career is emphasized. In an effort to study the rewards and costs of WASP marriages and to discover the structural conditions under…

  13. Partnering with the NCPV (Brochure)

    SciTech Connect

    Not Available

    2013-06-01

    Brochure that explains the basic partnering opportunities that exist within the National Center for Photovoltaics for industry and university groups: non-proprietary partnering opportunities, competitive solicitations, Technology Partnership Agreements, seed fund to develop Technology Partnership Agreements, Hands-On PV Experience Workshop, and NCPV Fellowship Program.

  14. Intimate Partner Violence. Prevention Update

    ERIC Educational Resources Information Center

    Higher Education Center for Alcohol, Drug Abuse, and Violence Prevention, 2011

    2011-01-01

    The Centers for Disease Control and Prevention (CDC) defines intimate partner violence (IPV) as violence between two people in a close relationship, including current and former spouses and dating partners. IPV occurs on a continuum from a single episode to ongoing battering and can include physical violence, sexual violence, threats, emotional…

  15. Care Partners and Multiple Sclerosis

    PubMed Central

    Quig, Mary Elizabeth; Tyry, Tuula; Marrie, Ruth Ann; Cutter, Gary; Shearin, Edward; Johnson, Kamau; Simsarian, James

    2015-01-01

    Background: Caring for someone with multiple sclerosis (MS) can be a stressful experience that requires clinical attention. We investigated the impact of caregiver stress on the emotional well-being and physical health of the MS care partner using the North American Research Committee on Multiple Sclerosis (NARCOMS) Registry. Methods: Care partners of NARCOMS participants were invited to complete an online questionnaire that captured demographic characteristics, health status, caregiver burden as measured by the Zarit Caregiver Burden Interview, and impact of caregiving on employment. Results: Of 1446 care partners who agreed to participate, 1333 had complete data. Most were men (n = 825, 61.9%), with a mean (SD) age of 51.1 (11.2) years. The mean (SD) Zarit total score was 24.6 (15.1), placing the overall group in the mild caregiver burden range. Compared with male care partners, female care partners reported higher levels of burden and stress and more medication use for stress/anxiety and mood disorders. Male care partners were more likely to report physical concerns. Care partners of people with primary progressive MS reported greater perceived burden than did partners of people with secondary progressive MS and relapsing-remitting MS. More than 40% of care partners (559 of 1288) had missed work during the past year owing to caregiving responsibilities. Conclusions: Care partners of people with MS have substantial physical and psychological health concerns and experience an adverse impact on employment. Future research should evaluate how to mitigate the adverse effects of caregiving and evaluate positive aspects of the role. PMID:26664330

  16. Quantification of Hydrogen Concentrations in Surface and Interface Layers and Bulk Materials through Depth Profiling with Nuclear Reaction Analysis.

    PubMed

    Wilde, Markus; Ohno, Satoshi; Ogura, Shohei; Fukutani, Katsuyuki; Matsuzaki, Hiroyuki

    2016-01-01

    Nuclear reaction analysis (NRA) via the resonant (1)H((15)N,αγ)(12)C reaction is a highly effective method of depth profiling that quantitatively and non-destructively reveals the hydrogen density distribution at surfaces, at interfaces, and in the volume of solid materials with high depth resolution. The technique applies a (15)N ion beam of 6.385 MeV provided by an electrostatic accelerator and specifically detects the (1)H isotope in depths up to about 2 μm from the target surface. Surface H coverages are measured with a sensitivity in the order of ~10(13) cm(-2) (~1% of a typical atomic monolayer density) and H volume concentrations with a detection limit of ~10(18) cm(-3) (~100 at. ppm). The near-surface depth resolution is 2-5 nm for surface-normal (15)N ion incidence onto the target and can be enhanced to values below 1 nm for very flat targets by adopting a surface-grazing incidence geometry. The method is versatile and readily applied to any high vacuum compatible homogeneous material with a smooth surface (no pores). Electrically conductive targets usually tolerate the ion beam irradiation with negligible degradation. Hydrogen quantitation and correct depth analysis require knowledge of the elementary composition (besides hydrogen) and mass density of the target material. Especially in combination with ultra-high vacuum methods for in-situ target preparation and characterization, (1)H((15)N,αγ)(12)C NRA is ideally suited for hydrogen analysis at atomically controlled surfaces and nanostructured interfaces. We exemplarily demonstrate here the application of (15)N NRA at the MALT Tandem accelerator facility of the University of Tokyo to (1) quantitatively measure the surface coverage and the bulk concentration of hydrogen in the near-surface region of a H2 exposed Pd(110) single crystal, and (2) to determine the depth location and layer density of hydrogen near the interfaces of thin SiO2 films on Si(100). PMID:27077920

  17. Risk Comparison among Youth Who Report Sex with Same-Sex versus Both-Sex Partners

    ERIC Educational Resources Information Center

    Moon, Martha W.; Fornili, Katherine; O'Briant, Amanda L.

    2007-01-01

    This article examines risk behavior among youth attending support groups for sexual minority youth in Richmond, Virginia, using a structured survey, with particular attention to partner selection and its relationship to risk. Within this generally high-risk group, youth reporting sex partners of both sexes had significantly higher risk profiles,…

  18. Intermolecular protein interactions in solutions of calf lens alpha-crystallin. Results from 1/T1 nuclear magnetic relaxation dispersion profiles.

    PubMed Central

    Koenig, S H; Brown, R D; Spiller, M; Chakrabarti, B; Pande, A

    1992-01-01

    From analyses of the magnetic field dependence of 1/T1 (NMRD profiles) of water protons in solutions of calf lens alpha-crystallin at several concentrations, we find two regimes of solute behavior in both cortical and nuclear preparations. Below approximately 15% vol/vol protein concentration, the solute molecules appear as compact globular proteins of approximately 1,350 (cortical) and approximately 1,700 (nuclear) kD. At higher concentrations, the effective solute particle size increases, reversibly, as evidenced by the appearance of spectra-like 14N peaks in the NMRD profiles and a change in the field and temperature dependence of 1/T1. At these higher concentrations, the profiles are very similar to those of calf gamma II-crystallin, a crystallin that undergoes an analogous transition near approximately 15% protein (Koenig, S. H., C.F. Beaulieu, R. D. Brown III, and M. Spiller, 1990. Biophys. J. 57:461-469). By comparison with recent analyses of NMRD results for solutions of immobilized proteins as models for the transition from protein solutions to tissue (Koenig, S. H., and R. D. Brown III. 1991. Prog. NMR Spectr. 22:487-567), we argue that alpha-crystallin solute behaves as aggregates approximately greater than 50,000 kD as protein concentration is progressively increased above 15%. Finally, the concentration dependence of the NMRD profiles of alpha- and gamma II-crystallin can readily explain recent osmotic pressure data, in particular the intersection of the respective pressure curves at approximately 23% vol/vol (Vérétout, F., and A. Tardieu. 1989. Eur. Biophys. J. 17:61-68). Images FIGURE 1 FIGURE 2 FIGURE 3 FIGURE 4 FIGURE 7 PMID:1504248

  19. Partner Ballroom Dance Robot -PBDR-

    NASA Astrophysics Data System (ADS)

    Kosuge, Kazuhiro; Takeda, Takahiro; Hirata, Yasuhisa; Endo, Mitsuru; Nomura, Minoru; Sakai, Kazuhisa; Koizumi, Mizuo; Oconogi, Tatsuya

    In this research, we have developed a dance partner robot, which has been developed as a platform for realizing the effective human-robot coordination with physical interaction. The robot could estimate the next dance step intended by a human and dance the step with the human. This paper introduce the robot referred to as PBDR (Partner Ballroom Dance Robot), which has performed graceful dancing with the human in EXPO 2005, Aichi, Japan.

  20. Partner violence and abortion characteristics.

    PubMed

    Colarossi, Lisa; Dean, Gillian

    2014-01-01

    We conducted a retrospective cohort study using randomly selected medical charts of women reporting a history of partner violence and women with no history of partner violence at the time of a family planning or abortion appointment (n = 6,564 per group). We analyzed lifetime history of partner violence for odds of lifetime history of abortion and miscarriage number, and birth control problems. To more closely match timing, we analyzed a subsample of 2,186 women reporting current violence versus not at the time of an abortion appointment for differences in gestational age, medical versus surgical method choice, and return for follow-up visit. After adjusting for years at risk and demographic characteristics, women with a past history of partner violence were not more likely to have ever had one abortion, but they were more likely to have had problems with birth control, repeat abortions, and miscarriages than women with no history of violence. Women with current partner violence were also more likely to be receiving an abortion at a later gestational age. We found no differences between the groups in return for abortion follow-up visit or choice of surgical versus medication abortion. Findings support screening for the influence of partner violence on reproductive health and related safety planning. PMID:24580133

  1. Using Smartphone Apps in STD Interviews to Find Sexual Partners

    PubMed Central

    Pennise, Melissa; Herpin, Kate; Owens, John; Bedard, Brenden A.; Weimer, Anita C.; Kennedy, Byron S.; Younge, Mary

    2015-01-01

    Objectives Smartphone applications (apps) are increasingly used to facilitate casual sexual relationships, increasing the risk of sexually transmitted diseases (STDs). In STD investigations, traditional contact elicitation methods can be enhanced with smartphone technology during field interviews. Methods In 2013, the Monroe County Department of Public Health conducted a large, multi-infection STD investigation among men who have sex with men (MSM) using both index case and cluster interviews. When patients indicated meeting sexual partners online, disease intervention specialists (DISs) had access to smartphone apps and were able to elicit partners through access to inboxes and profiles where traditional contact information was lacking. Social network mapping was used to display the extent of the investigation and the impact of access to smartphones on the investigation. Results A total of 14 index patient interviews and two cluster interviews were conducted; 97 individuals were identified among 117 sexual dyads. On average, eight partners were elicited per interview (range: 1–31). The seven individuals who used apps to find partners had an average of three Internet partners (range: 1–5). Thirty-six individuals either had a new STD (n=7) or were previously known to be HIV-positive (n=29). Of the 117 sexual dyads, 21 (18%) originated either online (n=8) or with a smartphone app (n=13). Of those originating online or with a smartphone app, six (29%) partners were located using the smartphone and two (10%) were notified of their exposure via a website. Three of the new STD/HIV cases were among partners who met online. Conclusion Smartphone technology used by DISs in the field improved contact elicitation and resulted in successful partner notification and case finding. PMID:25931628

  2. (1)H-Nuclear magnetic resonance-based metabolic profiling of nonsteroidal anti-inflammatory drug-induced adverse effects in rats.

    PubMed

    Um, So Young; Park, Jung Hyun; Chung, Myeon Woo; Choi, Ki Hwan; Lee, Hwa Jeong

    2016-09-10

    Nonsteroidal anti-inflammatory drugs (NSAIDs), which are globally prescribed, exhibit mainly anti-inflammatory and analgesic effects but also can cause adverse effects including gastrointestinal erosions, ulceration, bleeding, and perforation. The purpose of this study was to investigate surrogate biomarkers associated with the gastrointestinal (GI) damage caused by NSAID treatment using pattern recognition analysis of (1)H-nuclear magnetic resonance ((1)H NMR) spectra of rat urine. Urine was collected for 5h after oral administration of the following NSAIDs at low or high doses: acetylsalicylic acid (10 or 200mgkg(-1)), diclofenac (0.5 or 15mgkg(-1)), piroxicam (1 or 10mgkg(-1)), indomethacin (1 or 25mgkg(-1)), or ibuprofen (10, or 150mgkg(-1)) as nonselective COX inhibitors and celecoxib (10 or 100mgkg(-1)) as a COX-2 selective inhibitor. The urine was analyzed using 500MHz (1)H NMR for spectral binning and targeted profiling and the level of gastric damage was examined. The nonselective COX inhibitors caused severe gastric damage while no lesions were observed in the celecoxib-treated rats. The (1)H NMR urine spectra were divided into spectral bins (0.04ppm) for global profiling, and a total of 44 endogenous metabolites were assigned for targeted profiling. Multivariate data analyses were performed to recognize the spectral pattern of endogenous metabolites related to NSAIDs using partial least square-discrimination analysis (PLS-DA). The (1)H NMR spectra clustered differently according to gastric damage score in global profiling. In targeted profiling, the endogenous metabolites of citrate, allantoin, 2-oxoglutarate, acetate, benzoate, glycine, and trimethylamine N-oxide were selected as putative biomarkers for gastric damage caused by NSAIDs. These putative biomarkers might be useful for predicting the risk of adverse effects caused by NSAIDs in the early stage of drug development process. PMID:27497650

  3. Intimate partner violence, partner notification, and expedited partner therapy: a qualitative study.

    PubMed

    Rosenfeld, Elian A; Marx, John; Terry, Martha A; Stall, Ronald; Pallatino, Chelsea; Borrero, Sonya; Miller, Elizabeth

    2016-07-01

    SummaryOver one-third of women experience intimate partner violence (IPV) in their lifetime. IPV increases the risk of infection and re-infection with sexually transmitted infections (STIs). The extent to which health care providers consider IPV when recommending partner notification and expedited partner therapy is unknown. The objective of this qualitative study was to understand health care providers' views on IPV and STIs when recommending partner treatment to patients with chlamydia. Using a purposive sampling strategy to include health care providers who treat young women at risk for chlamydia, 23 semi-structured, in-depth interviews were conducted. While some health care providers expressed concern for their patients' safety and believed assessing for IPV was needed before provision of expedited partner therapy, nearly a third had not considered the links between IPV and STIs. Strategies used by health care providers to assess for IPV did not include inquiry about specific behaviours related to IPV, STI risk, and sexual coercion. Many health care providers understand the risk for IPV in the setting of STI treatment, yet a significant portion of those interviewed failed to recognise the link between IPV and STIs. Provider education is necessary to increase knowledge and implement more effective inquiry and counselling about IPV to more safely recommend expedited partner therapy. PMID:26088259

  4. Publishing protocols for partnered research.

    PubMed

    Hysong, Sylvia J; Woodard, LeChauncy; Garvin, Jennifer H; Murawsky, Jeffrey; Petersen, Laura A

    2014-12-01

    Published scientific protocols are advocated as a means of controlling bias in research reporting. Indeed, many journals require a study protocol with manuscript submission. However, publishing protocols of partnered research (PPR) can be challenging in light of the research model's dynamic nature, especially as no current reporting standards exist. Nevertheless, as these protocols become more prevalent, a priori documentation of methods in partnered research studies becomes increasingly important. Using as illustration a suite of studies aimed at improving coordination and communication in the primary care setting, we sought to identify challenges in publishing PPR relative to traditional designs, present alternative solutions to PPR publication, and propose an initial checklist of content to be included in protocols of partnered research. Challenges to publishing PPR include reporting details of research components intended to be co-created with operational partners, changes to sampling and entry strategy, and alignment of scientific and operational goals. Proposed solutions include emulating reporting standards of qualitative research, participatory action research, and adaptive trial designs, as well as embracing technological tools that facilitate publishing adaptive protocols, with version histories that are able to be updated as major protocol changes occur. Finally, we present a proposed checklist of reporting elements for partnered research protocols. PMID:25355092

  5. Violence between Therapy-Seeking Veterans and Their Partners: Prevalence and Characteristics of Nonviolent, Mutually Violent, and One-Sided Violent Couples

    ERIC Educational Resources Information Center

    Teten, Andra L.; Sherman, Michelle D.; Han, Xiaotong

    2009-01-01

    Among male veterans and their female partners seeking therapy for relationship issues, three violence profiles were identified based on self-reports of physical violence: nonviolent, in which neither partner reported perpetrating physical violence (44%); one-sided violent, in which one partner reported perpetrating violence (30%); and mutually…

  6. Isotopic signature of selected lanthanides for nuclear activities profiling using cloud point extraction and ICP-MS/MS.

    PubMed

    Labrecque, Charles; Lebed, Pablo J; Larivière, Dominic

    2016-05-01

    The presence of fission products, which include numerous isotopes of lanthanides, can impact the isotopic ratios of these elements in the environment. A cloud point extraction (CPE) method was used as a preconcentration/separation strategy prior to measurement of isotopic ratios of three lanthanides (Nd, Sm, and Eu) by inductively coupled plasma tandem mass spectrometry (ICP-MS/MS). To minimise polyatomic interference, the combination of interferents removal by CPE, reaction/collision cell conditions in He and NH3 mode and tandem quadrupole configuration was investigated and provided optimal results for the determination of isotopic ratio in environmental samples. Isotopic ratios were initially measured in San Joaquin soil (NIST-2709a), an area with little contamination of nuclear origin. Finally, samples collected from three sites with known nuclear activities (Fangataufa Lagoon in French Polynesia, Chernobyl and the Ottawa River near Chalk River Laboratory) were analysed and all exhibited altered isotopic ratios for (143/145)Nd, (147/149)Sm, and (151/153)Eu. These results demonstrate the potential of CPE and ICP-MS/MS for the detection of altered isotopic ratio in environmental samples collected in area subjected to nuclear anthropogenic contamination. The detection of variations in these isotopic ratios of fission products represents the first application of CPE in nuclear forensic investigations of environmental samples. PMID:26895346

  7. Three-dimensional Stellar Kinematics at the Galactic Center: Measuring the Nuclear Star Cluster Spatial Density Profile, Black Hole Mass, and Distance

    NASA Astrophysics Data System (ADS)

    Do, T.; Martinez, G. D.; Yelda, S.; Ghez, A.; Bullock, J.; Kaplinghat, M.; Lu, J. R.; Peter, A. H. G.; Phifer, K.

    2013-12-01

    We present three-dimensional (3D) kinematic observations of stars within the central 0.5 pc of the Milky Way (MW) nuclear star cluster (NSC) using adaptive optics imaging and spectroscopy from the Keck telescopes. Recent observations have shown that the cluster has a shallower surface density profile than expected for a dynamically relaxed cusp, leading to important implications for its formation and evolution. However, the true 3D profile of the cluster is unknown due to the difficulty in de-projecting the stellar number counts. Here, we use spherical Jeans modeling of individual proper motions and radial velocities to constrain, for the first time, the de-projected spatial density profile, cluster velocity anisotropy, black hole mass (M BH), and distance to the Galactic center (R 0) simultaneously. We find that the inner stellar density profile of the late-type stars, ρ(r)vpropr -γ, have a power law slope \\gamma =0.05_{-0.60}^{+0.29}, much more shallow than the frequently assumed Bahcall-Wolf slope of γ = 7/4. The measured slope will significantly affect dynamical predictions involving the cluster, such as the dynamical friction time scale. The cluster core must be larger than 0.5 pc, which disfavors some scenarios for its origin. Our measurement of M_{BH}=5.76_{-1.26}^{+1.76}\\times 10^6 M ⊙ and R_0=8.92_{-0.55}^{+0.58} kpc is consistent with that derived from stellar orbits within 1'' of Sgr A*. When combined with the orbit of S0-2, the uncertainty on R 0 is reduced by 30% (8.46_{-0.38}^{+0.42}\\ kpc). We suggest that the MW NSC can be used in the future in combination with stellar orbits to significantly improve constraints on R 0.

  8. Small Heterodimer Partner and Innate Immune Regulation

    PubMed Central

    Jin, Hyo Sun

    2016-01-01

    The nuclear receptor superfamily consists of the steroid and non-steroid hormone receptors and the orphan nuclear receptors. Small heterodimer partner (SHP) is an orphan family nuclear receptor that plays an essential role in the regulation of glucose and cholesterol metabolism. Recent studies reported a previously unidentified role for SHP in the regulation of innate immunity and inflammation. The innate immune system has a critical function in the initial response against a variety of microbial and danger signals. Activation of the innate immune response results in the induction of inflammatory cytokines and chemokines to promote anti-microbial effects. An excessive or uncontrolled inflammatory response is potentially harmful to the host, and can cause tissue damage or pathological threat. Therefore, the innate immune response should be tightly regulated to enhance host defense while preventing unwanted immune pathologic responses. In this review, we discuss recent studies showing that SHP is involved in the negative regulation of toll-like receptor-induced and NLRP3 (NACHT, LRR and PYD domains-containing protein 3)-mediated inflammatory responses in innate immune cells. Understanding the function of SHP in innate immune cells will allow us to prevent or modulate acute and chronic inflammation processes in cases where dysregulated innate immune activation results in damage to normal tissues. PMID:26754583

  9. Small Heterodimer Partner and Innate Immune Regulation.

    PubMed

    Yuk, Jae Min; Jin, Hyo Sun; Jo, Eun Kyeong

    2016-03-01

    The nuclear receptor superfamily consists of the steroid and non-steroid hormone receptors and the orphan nuclear receptors. Small heterodimer partner (SHP) is an orphan family nuclear receptor that plays an essential role in the regulation of glucose and cholesterol metabolism. Recent studies reported a previously unidentified role for SHP in the regulation of innate immunity and inflammation. The innate immune system has a critical function in the initial response against a variety of microbial and danger signals. Activation of the innate immune response results in the induction of inflammatory cytokines and chemokines to promote anti-microbial effects. An excessive or uncontrolled inflammatory response is potentially harmful to the host, and can cause tissue damage or pathological threat. Therefore, the innate immune response should be tightly regulated to enhance host defense while preventing unwanted immune pathologic responses. In this review, we discuss recent studies showing that SHP is involved in the negative regulation of toll-like receptor-induced and NLRP3 (NACHT, LRR and PYD domains-containing protein 3)-mediated inflammatory responses in innate immune cells. Understanding the function of SHP in innate immune cells will allow us to prevent or modulate acute and chronic inflammation processes in cases where dysregulated innate immune activation results in damage to normal tissues. PMID:26754583

  10. 2H nuclear magnetic resonance order parameter profiles suggest a change of molecular shape for phosphatidylcholines containing a polyunsaturated acyl chain.

    PubMed Central

    Holte, L. L.; Peter, S. A.; Sinnwell, T. M.; Gawrisch, K.

    1995-01-01

    Solid-state 2H nuclear magnetic resonance spectroscopy was used to determine the orientational order parameter profiles for a series of phosphatidylcholines with perdeuterated stearic acid, 18:0d35, in position sn-1 and 18:1 omega 9, 18:2 omega 6, 18:3 omega 3, 20:4 omega 6, 20:5 omega 3, or 22:6 omega 3 in position sn-2. The main phase transition temperatures were derived from a first moment analysis, and order parameter profiles of sn-1 chains were calculated from dePaked nuclear magnetic resonance powder patterns. Comparison of the profiles at 37 degrees C showed that unsaturation causes an inhomogenous disordering along the sn-1 chain. Increasing sn-2 chain unsaturation from one to six double bonds resulted in a 1.6-kHz decrease in quadrupolar splittings of the sn-1 chain in the upper half of the chain (or plateau region) and maximum splitting difference of 4.4 kHz at methylene carbon 14. The change in chain order corresponds to a decrease in the 18:0 chain length of 0.4 +/- 0.2 A with 18:2 omega 6 versus 18:1 omega 9 in position sn-2. Fatty acids containing three or more double bonds in sn-2 showed a decrease in sn-1 chain length of 0.7 +/- 0.2 A compared with 18:1 omega 9. The chain length of all lipids decreased with increasing temperature. Highly unsaturated phosphatidylcholines (three or more double bonds in sn-2) had shorter sn-1 chains, but the chain length was somewhat less sensitive to temperature. The profiles reveal that the sn-1 chain exhibits a selective increase in motional freedom in a region located toward the bottom half of the chain as sn-2 unsaturation is increased. This corresponds to an area increase around carbon atom number 14 that is three to four times greater than the increase for the top part of the chain. A similar asymmetric decrease in order, largest toward the methyl end of the chain, was observed when 1 -palmitoyl-2-oleoylphosphatidylethanolamine goes from a lamellar to an inverse hexagonal (H,,) phase. This is consistent with a

  11. Tetrapyrrole profiling in Arabidopsis seedlings reveals that retrograde plastid nuclear signaling is not due to Mg-protoporphyrin IX accumulation

    PubMed Central

    Moulin, Michael; McCormac, Alex C.; Terry, Matthew J.; Smith, Alison G.

    2008-01-01

    Chloroplast biogenesis involves careful coordination of both plastid and nuclear gene expression, which is achieved in part by retrograde signaling from the chloroplast to the nucleus. This can be demonstrated by the fact that the herbicide, Norflurazon (NF), which causes bleaching of chloroplasts, prevents the light induction of photosynthesis-related genes in the nucleus. It has been proposed that the tetrapyrrole pathway intermediate Mg-protoporphyrin IX acts as the signaling molecule in this pathway and accumulates in the chloroplasts and cytosol of the cell after NF treatment. Here we present data that demonstrate that this model is too simplistic. We have developed a sensitive liquid chromatography-mass spectrometry (LC/MS) method to measure tetrapyrrole intermediates and have shown that no Mg-protoporphyrin IX, nor indeed any other chlorophyll-biosynthesis intermediate, can be detected in NF-treated plants under conditions in which nuclear gene expression is repressed. Conversely when endogenous Mg-protoporphyrin IX levels are artificially increased by supplementation with the tetrapyrrole precursor, 5-aminolevulinic acid, the expression of nuclear-encoded photosynthetic genes is induced, not repressed. We also demonstrate that NF-treatment leads to a strong down-regulation of tetrapyrrole biosynthesis genes, consistent with the absence of an accumulation of tetrapyrrole intermediates. Finally, there is no correlation between nuclear-gene expression and any of the chlorophyll biosynthetic intermediates over a range of growth conditions and treatments. Instead, it is possible that a perturbation of tetrapyrrole synthesis may lead to localized ROS production or an altered redox state of the plastid, which could mediate retrograde signaling. PMID:18818314

  12. The Computer as Lab Partner.

    ERIC Educational Resources Information Center

    Nicklin, R. C.

    1985-01-01

    Microcomputers can record laboratory measurements which human laboratory partners can never collect. Simple, harder, and general-purpose interfaces are discussed, with suggestions for several experiments involving an exercise bike, acceleration, and pendulums. Additional applications with pH meters, spectrophotometers, and chromatographs are also…

  13. OLC Partners with the People.

    ERIC Educational Resources Information Center

    Dellinger, Laura M.

    2001-01-01

    Discusses ways in which Oglala Lakota College (South Dakota) helps to strengthen the cultural fabric of the Lakota community and how it has partnered with other institutions of higher learning throughout the state. Reports that the college has a number of community-based initiatives that emphasize the relationship between academics and ancestral…

  14. The Symmetry of Partner Modelling

    ERIC Educational Resources Information Center

    Dillenbourg, Pierre; Lemaignan, Séverin; Sangin, Mirweis; Nova, Nicolas; Molinari, Gaëlle

    2016-01-01

    Collaborative learning has often been associated with the construction of a shared understanding of the situation at hand. The psycholinguistics mechanisms at work while establishing common grounds are the object of scientific controversy. We postulate that collaborative tasks require some level of mutual modelling, i.e. that each partner needs…

  15. Partnering for Student Transfer Success

    ERIC Educational Resources Information Center

    Washington State Board for Community and Technical Colleges, 2015

    2015-01-01

    Washington's community and technical colleges, private non-profit baccalaureate, and public baccalaureate colleges and universities have a proud history of partnering to serve students. Nowhere is this cooperation more evident than in the smooth transfer process from community and technical colleges into four-year colleges and universities. This…

  16. Macomb Reading Partners Research Report.

    ERIC Educational Resources Information Center

    Snoddy, James E.

    A study evaluated Macomb Reading Partners (MRP), the tutoring program of the Macomb Literacy Project. It researched the effectiveness of literacy training and its impact on the lives of a target group of 30 automotive workers. Data sources were a structured interview, the Word Opposites Test of the Botel Reading Inventory (1962), and participant…

  17. Partner Teaching: A Promising Model

    ERIC Educational Resources Information Center

    Bronson, Carroll E.; Dentith, Audrey M.

    2014-01-01

    This paper describes an ethnographic case study of a partner or co-teaching classroom in an urban preschool classroom. As part of a larger project that evaluated classroom size and team teaching structures in Kindergarten classrooms in several high poverty urban schools, one successful co-teaching classroom was studied further. Systematic…

  18. Measuring radial profiles of nuclear burn in ICF implosions at OMEGA and the NIF using proton emission imaging

    NASA Astrophysics Data System (ADS)

    Seguin, F. H.; Rinderknecht, H. G.; Rosenberg, M.; Zylstra, A.; Frenje, J.; Li, C. K.; Petrasso, R.; Marshall, F. J.; Sangster, T. C.; Hoffman, N. M.; Amendt, P. A.; Bellei, C.; Le Pape, S.; Wilks, S. C.

    2014-10-01

    Fusion reactions in ICF implosions of D3He-filled capsules produce 14.7-MeV D3He protons and 3-MeV DD protons. Measurements of the spatial distributions of the D3He and DD reactions are studied with a penumbral imaging system that utilizes a CR-39-based imaging detector to simultaneously record separate penumbral images of the two types of protons. Measured burn profiles are useful for studying implosion physics and provide a critical test for benchmarking simulations. Recent implosions at OMEGA of CD capsules containing 3He gas fill and SiO2 capsules containing low-pressure D3He gas were expected to have hollow D3He burn profiles (in the 3He-filled capsule, due to fuel-shell mix), but penumbral imaging showed that the reactions were centrally peaked due to enhanced ion diffusion. The imaging technique is to be implemented soon on the NIF. This work was supported in part by NLUF, DOE, and LLE.

  19. Measuring the stellar luminosity function and spatial density profile of the inner 0.5 pc of the Milky Way nuclear star cluster

    NASA Astrophysics Data System (ADS)

    Do, Tuan; Ghez, Andrea; Lu, Jessica R.; Morris, Mark R.; Yelda, Sylvana; Martinez, Gregory D.; Peter, Annika H. G.; Wright, Shelley; Bullock, James; Kaplinghat, Manoj; Matthews, K.

    2012-07-01

    We report on measurements of the luminosity function of early (young) and late-type (old) stars in the central 0.5 pc of the Milky Way nuclear star cluster as well as the density profiles of both components. The young (~ 6 Myr) and old stars (> 1 Gyr) in this region provide different physical probes of the environment around a supermassive black hole; the luminosity function of the young stars offers us a way to measure the initial mass function from star formation in an extreme environment, while the density profile of the old stars offers us a probe of the dynamical interaction of a star cluster with a massive black hole. The two stellar populations are separated through a near-infrared spectroscopic survey using the integral-field spectrograph OSIRIS on Keck II behind the laser guide star adaptive optics system. This spectroscopic survey is able to separate early-type (young) and late-type (old) stars with a completeness of 50% at K' = 15.5. We describe our method of completeness correction using a combination of star planting simulations and Bayesian inference. The completeness corrected luminosity function of the early-type stars contains significantly more young stars at faint magnitudes compared to previous surveys with similar depth. In addition, by using proper motion and radial velocity measurements along with anisotropic spherical Jeans modeling of the cluster, it is possible to measure the spatial density profile of the old stars, which has been difficult to constrain with number counts alone. The most probable model shows that the spatial density profile, n(r) propto r-γ, to be shallow with γ = 0.4 ± 0.2, which is much flatter than the dynamically relaxed case of γ = 3/2 to 7/4, but does rule out a 'hole' in the distribution of old stars. We show, for the first time, that the spatial density profile, the black hole mass, and velocity anisotropy can be fit simultaneously to obtain a black hole mass that is consistent with that derived from

  20. Nuclear APC.

    PubMed

    Neufeld, Kristi L

    2009-01-01

    Mutational inactivation of the tumor suppressor gene APC (Adenomatous polyposis coli) is thought to be an initiating step in the progression of the vast majority ofcolorectal cancers. Attempts to understand APC function have revealed more than a dozen binding partners as well as several subcellular localizations including at cell-cell junctions, associated with microtubules at the leading edge of migrating cells, at the apical membrane, in the cytoplasm and in the nucleus. The present chapter focuses on APC localization and functions in the nucleus. APC contains two classical nuclear localization signals, with a third domain that can enhance nuclear import. Along with two sets of nuclear export signals, the nuclear localization signals enable the large APC protein to shuttle between the nucleus and cytoplasm. Nuclear APC can oppose beta-catenin-mediated transcription. This down-regulation of nuclear beta-catenin activity by APC most likely involves nuclear sequestration of beta-catenin from the transcription complex as well as interaction of APC with transcription corepressor CtBP. Additional nuclear binding partners for APC include transcription factor activator protein AP-2alpha, nuclear export factor Crm1, protein tyrosine phosphatase PTP-BL and perhaps DNA itself. Interaction of APC with polymerase beta and PCNA, suggests a role for APC in DNA repair. The observation that increases in the cytoplasmic distribution of APC correlate with colon cancer progression suggests that disruption of these nuclear functions of APC plays an important role in cancer progression. APC prevalence in the cytoplasm of quiescent cells points to a potential function for nuclear APC in control of cell proliferation. Clear definition of APC's nuclear function(s) will expand the possibilities for early colorectal cancer diagnostics and therapeutics targeted to APC. PMID:19928349

  1. Molecular Profiling of Giant Cell Tumor of Bone and the Osteoclastic Localization of Ligand for Receptor Activator of Nuclear Factor κB

    PubMed Central

    Morgan, Teresa; Atkins, Gerald J.; Trivett, Melanie K.; Johnson, Sandra A.; Kansara, Maya; Schlicht, Stephen L.; Slavin, John L.; Simmons, Paul; Dickinson, Ian; Powell, Gerald; Choong, Peter F.M.; Holloway, Andrew J.; Thomas, David M.

    2005-01-01

    Giant cell tumor of bone (GCT) is a generally benign, osteolytic neoplasm comprising stromal cells and osteoclast-like giant cells. The osteoclastic cells, which cause bony destruction, are thought to be recruited from normal monocytic pre-osteoclasts by stromal cell expression of the ligand for receptor activator of nuclear factor κB (RANKL). This model forms the foundation for clinical trials in GCTs of novel cancer therapeutics targeting RANKL. Using expression profiling, we identified both osteoblast and osteoclast signatures within GCTs, including key regulators of osteoclast differentiation and function such as RANKL, a C-type lectin, osteoprotegerin, and the wnt inhibitor SFRP4. After ex vivo generation of stromal- and osteoclast-enriched cultures, we unexpectedly found that RANKL mRNA and protein were more highly expressed in osteoclasts than in stromal cells, as determined by expression profiling, flow cytometry, immunohistochemistry, and reverse transcriptase-polymerase chain reaction. The expression patterns of molecules implicated in signaling between stromal cells and monocytic osteoclast precursors were analyzed in both primary and fractionated GCTs. Finally, using array-based comparative genomic hybridization, neither GCTs nor the derived stromal cells demonstrated significant genomic gains or losses. These data raise questions regarding the role of RANKL in GCTs that may be relevant to the development of molecularly targeted therapeutics for this disease. PMID:15972958

  2. Nuclear transcriptome profiling of induced pluripotent stem cells and embryonic stem cells identify non-coding loci resistant to reprogramming

    PubMed Central

    Fort, Alexandre; Yamada, Daisuke; Hashimoto, Kosuke; Koseki, Haruhiko; Carninci, Piero

    2015-01-01

    Identification of functionally relevant differences between induced pluripotent stem cells (iPSC) and reference embryonic stem cells (ESC) remains a central question for therapeutic applications. Differences in gene expression between iPSC and ESC have been examined by microarray and more recently with RNA-SEQ technologies. We here report an in depth analyses of nuclear and cytoplasmic transcriptomes, using the CAGE (cap analysis of gene expression) technology, for 5 iPSC clones derived from mouse lymphocytes B and 3 ESC lines. This approach reveals nuclear transcriptomes significantly more complex in ESC than in iPSC. Hundreds of yet not annotated putative non-coding RNAs and enhancer-associated transcripts specifically transcribed in ESC have been detected and supported with epigenetic and chromatin-chromatin interactions data. We identified super-enhancers transcriptionally active specifically in ESC and associated with genes implicated in the maintenance of pluripotency. Similarly, we detected non-coding transcripts of yet unknown function being regulated by ESC specific super-enhancers. Taken together, these results demonstrate that current protocols of iPSC reprogramming do not trigger activation of numerous cis-regulatory regions. It thus reinforces the need for already suggested deeper monitoring of the non-coding transcriptome when characterizing iPSC clones. Such differences in regulatory transcript expression may indeed impact their potential for clinical applications. PMID:25664506

  3. The uterine and vascular actions of estetrol delineate a distinctive profile of estrogen receptor α modulation, uncoupling nuclear and membrane activation

    PubMed Central

    Abot, Anne; Fontaine, Coralie; Buscato, Mélissa; Solinhac, Romain; Flouriot, Gilles; Fabre, Aurélie; Drougard, Anne; Rajan, Shyamala; Laine, Muriel; Milon, Alain; Muller, Isabelle; Henrion, Daniel; Adlanmerini, Marine; Valéra, Marie-Cécile; Gompel, Anne; Gerard, Céline; Péqueux, Christel; Mestdagt, Mélanie; Raymond-Letron, Isabelle; Knauf, Claude; Ferriere, François; Valet, Philippe; Gourdy, Pierre; Katzenellenbogen, Benita S; Katzenellenbogen, John A; Lenfant, Françoise; Greene, Geoffrey L; Foidart, Jean-Michel; Arnal, Jean-François

    2014-01-01

    Estetrol (E4) is a natural estrogen with a long half-life produced only by the human fetal liver during pregnancy. The crystal structures of the estrogen receptor α (ERα) ligand-binding domain bound to 17β-estradiol (E2) and E4 are very similar, as well as their capacity to activate the two activation functions AF-1 and AF-2 and to recruit the coactivator SRC3. In vivo administration of high doses of E4 stimulated uterine gene expression, epithelial proliferation, and prevented atheroma, three recognized nuclear ERα actions. However, E4 failed to promote endothelial NO synthase activation and acceleration of endothelial healing, two processes clearly dependent on membrane-initiated steroid signaling (MISS). Furthermore, E4 antagonized E2 MISS-dependent effects in endothelium but also in MCF-7 breast cancer cell line. This profile of ERα activation by E4, uncoupling nuclear and membrane activation, characterizes E4 as a selective ER modulator which could have medical applications that should now be considered further. PMID:25214462

  4. The Role of Character Strengths in Adolescent Romantic Relationships: An Initial Study on Partner Selection and Mates' Life Satisfaction

    ERIC Educational Resources Information Center

    Weber, Marco; Ruch, Willibald

    2012-01-01

    The present study investigated the role of 24 character strengths in 87 adolescent romantic relationships focusing on their role in partner selection and their role in mates' life satisfaction. Measures included the Values in Action Inventory of Strengths for Youth, the Students' Life Satisfaction Scale, and an Ideal Partner Profiler for the…

  5. Comprehensive profiling and marker identification in non-volatile citrus oil residues by mass spectrometry and nuclear magnetic resonance.

    PubMed

    Marti, Guillaume; Boccard, Julien; Mehl, Florence; Debrus, Benjamin; Marcourt, Laurence; Merle, Philippe; Delort, Estelle; Baroux, Lucie; Sommer, Horst; Rudaz, Serge; Wolfender, Jean-Luc

    2014-05-01

    The detailed characterization of cold-pressed lemon oils (CPLOs) is of great importance for the flavor and fragrance (F&F) industry. Since a control of authenticity by standard analytical techniques can be bypassed using elaborated adulterated oils to pretend a higher quality, a combination of advanced orthogonal methods has been developed. The present study describes a combined metabolomic approach based on UHPLC-TOF-MS profiling and (1)H NMR fingerprinting to highlight metabolite differences on a set of representative samples used in the F&F industry. A new protocol was set up and adapted to the use of CPLO residues. Multivariate analysis based on both fingerprinting methods showed significant chemical variations between Argentinian and Italian samples. Discriminating markers identified in mixtures belong to furocoumarins, flavonoids, terpenoids and fatty acids. Quantitative NMR revealed low citropten and high bergamottin content in Italian samples. The developed metabolomic approach applied to CPLO residues gives some new perspectives for authenticity assessment. PMID:24360445

  6. Talking to Your Partner about Condoms

    MedlinePlus

    ... at the top of your (or your partner's) penis. This gets rid of trapped air, which can ... Remove the condom immediately after ejaculation, before the penis softens. You or your partner should hold the ...

  7. For Better Skin Cancer Checks, Partner Up

    MedlinePlus

    ... gov/medlineplus/news/fullstory_159632.html For Better Skin Cancer Checks, Partner Up Melanoma survivors benefited when ... out: Getting a partner trained to spot potential skin cancers can be a lifesaver for melanoma survivors, ...

  8. Dilemmas in intimate partner violence.

    PubMed

    Cook, Rebecca J; Dickens, Bernard M

    2009-07-01

    Intimate partner violence (IPV), usually men's violence against women, appears universal. It may be associated with pregnancy, but this may be because pregnant women receive more medical attention. Violence may cause bruises, abrasions, and cuts, but its extremes include hospitalization, death, and suicide. IPV is often disclosed when women are asked why they feel in poor health or depressed. A legal dilemma arises when healthcare providers consider that intervention such as law-enforcement is appropriate, but patients refuse approval. Patients may fatalistically accept violence, or fear loss of support for their children and themselves if their partners are held in custody. Legal reforms, such as punishing spousal rape, may provide some protection of women's autonomy. Ethical dilemmas concern intervention without patients' approval, and whether treating violent injuries without taking preventive action breaches the principle to Do No Harm. Professional advocacy and social action have been urged to expose and reduce IPV. PMID:19368921

  9. Partner attachment and interpersonal characteristics.

    PubMed

    Kilmann, Peter R; Finch, Holmes; Parnell, Michele M; Downer, Jason T

    2013-01-01

    This study investigated partner attachment and interpersonal characteristics in 134 nonclinical couples in long-term marriages. Irrespective of gender, spouses with greater anxiety over abandonment or discomfort with closeness endorsed dysfunctional relationship beliefs to a greater extent. On the anxiety over abandonment dimension, husbands with higher scores were rated less aggressive, less controlling, and more rebellious, whereas wives with higher scores were rated more dependent, more self-critical, and less competitive. Husbands higher on discomfort with closeness were rated less cooperative and responsible and were rated more aggressive and rebellious. Matched secure couples reported lower marital dissatisfaction than matched insecure or mismatched couples. Future research should contrast samples of nonclinical and clinical couples by marital duration to identify specific partner behaviors that are likely to foster marital dissatisfaction within particular attachment pairings. The authors' findings suggest the importance of marital therapists being attuned to the attachment-related beliefs and interpersonal styles uniquely operating within each couple. PMID:23252639

  10. Partnering: The foundation for performance

    SciTech Connect

    Edelman, L.

    1994-12-31

    Over the past several decades, the US has experienced an unprecedented increase in the number of disputes in litigation. The environmental area, particularly contracts involving remediation projects, have not been immune from this situation. The adverse impact of this litigation mindset on the financial and personnel resources of the contracting parties has escalated and the detrimental effect on contractual relationships has become more apparent. Both owners and contractors are confronted with unrealized contract expectations, hostility on the jobsite and disappointment in the traditional dispute resolution processes. Relying exclusively on litigation when negotiations fail to settle contract disputes is time consuming, costly and frustrating. Now in the 1990s, the Corps along with the construction industry are moving to establish a new relationship beneficial to all contracting parties that focus on disputes avoidance. This new relationship is fostered by a process called Partnering. In undertaking environmental remediation work, Partnering can lay the foundation for a successful relationship among all involved parties.

  11. Light 't Hooft top partners

    NASA Astrophysics Data System (ADS)

    Cacciapaglia, Giacomo; Parolini, Alberto

    2016-04-01

    Vectorlike quarks, usually dubbed top partners, are a common presence in composite Higgs models. Being composite objects, their mass is expected to be of the order of their inverse size, that is the condensation scale of the new strong interactions. Light top partners, while not being a generic prediction, are, however, often considered in phenomenological models. We suggest that their lightness may be due to the matching of global 't Hooft anomalies of the underlying theory. We check this mechanism in explicit models, showing that, in one case, composite fermions with the quantum numbers of the top quark obtain a mass which is controlled by a soft breaking term and can be made parametrically small.

  12. Chemical recognition of partner plant species by foundress ant queens in Macaranga-Crematogaster myrmecophytism.

    PubMed

    Inui, Y; Itioka, T; Murase, K; Yamaoka, R; Itino, T

    2001-10-01

    The partnership in the Crematogaster-Macaranga ant-plant interaction is highly species-specific. Because a mutualistic relationship on a Macaranga plant starts with colonization by a foundress queen of a partner Crematogaster species, we hypothesized that the foundress queens select their partner plant species by chemical recognition. We tested this hypothesis with four sympatric Macaranga species and their Crematogaster plant-ant species. We demonstrated that foundress Crematogaster queens can recognize their partner Macaranga species by contact with the surface of the seedlings, that they can recognize compounds from the stem surface of seedlings of their partner plant species, and that the gas chromatographic profiles are characteristic of the plant species. These findings support the hypothesis that foundress queens of the Crematogaster plant-ant species select their partner Macaranga species by recognizing nonvolatile chemical characteristics of the stem surfaces of seedlings. PMID:11710609

  13. Desistance From Intimate Partner Violence

    PubMed Central

    Bowen, Erica; Brown, Sarah; Sleath, Emma

    2015-01-01

    Intimate partner violence (IPV) is an international issue that social and criminal justice workers will encounter regularly. It has been identified that men can, and do stop using, or desist from, IPV although it is unclear how this process of change develops. This article introduces a conceptual model to outline how the process of desistance evolves and what it encompasses. Using thematic analysis of interview data from partner-violent men, survivors, and treatment facilitators, the resulting model demonstrates that the process of change is a dynamic one where men’s use of, and cessation from, violence needs to be understood within the context of each individual’s life. Three global themes were developed: (a) lifestyle behaviors (violent): what is happening in the men’s lives when they use violence; (b) catalysts for change: the triggers and transitions required to initiate the process of change; and (c) lifestyle behaviors (non-violent): what is different in the men’s lives when they have desisted from IPV. The purpose of this model is to offer a framework for service providers to assist them to manage the process of change in partner-violent men. PMID:25315483

  14. THREE-DIMENSIONAL STELLAR KINEMATICS AT THE GALACTIC CENTER: MEASURING THE NUCLEAR STAR CLUSTER SPATIAL DENSITY PROFILE, BLACK HOLE MASS, AND DISTANCE

    SciTech Connect

    Do, T.; Martinez, G. D.; Bullock, J.; Kaplinghat, M.; Peter, A. H. G.; Yelda, S.; Ghez, A.; Phifer, K.; Lu, J. R.

    2013-12-10

    We present three-dimensional (3D) kinematic observations of stars within the central 0.5 pc of the Milky Way (MW) nuclear star cluster (NSC) using adaptive optics imaging and spectroscopy from the Keck telescopes. Recent observations have shown that the cluster has a shallower surface density profile than expected for a dynamically relaxed cusp, leading to important implications for its formation and evolution. However, the true 3D profile of the cluster is unknown due to the difficulty in de-projecting the stellar number counts. Here, we use spherical Jeans modeling of individual proper motions and radial velocities to constrain, for the first time, the de-projected spatial density profile, cluster velocity anisotropy, black hole mass (M {sub BH}), and distance to the Galactic center (R {sub 0}) simultaneously. We find that the inner stellar density profile of the late-type stars, ρ(r)∝r {sup –γ}, have a power law slope γ=0.05{sub −0.60}{sup +0.29}, much more shallow than the frequently assumed Bahcall-Wolf slope of γ = 7/4. The measured slope will significantly affect dynamical predictions involving the cluster, such as the dynamical friction time scale. The cluster core must be larger than 0.5 pc, which disfavors some scenarios for its origin. Our measurement of M{sub BH}=5.76{sub −1.26}{sup +1.76}×10{sup 6} M {sub ☉} and R{sub 0}=8.92{sub −0.55}{sup +0.58} kpc is consistent with that derived from stellar orbits within 1'' of Sgr A*. When combined with the orbit of S0-2, the uncertainty on R {sub 0} is reduced by 30% (8.46{sub −0.38}{sup +0.42} kpc). We suggest that the MW NSC can be used in the future in combination with stellar orbits to significantly improve constraints on R {sub 0}.

  15. Adult Attachment as a Risk Factor for Intimate Partner Violence : The "Mispairing" of Partners' Attachment Styles

    ERIC Educational Resources Information Center

    Doumas, Diana M.; Pearson, Christine L.; Elgin, Jenna E.; McKinley, Lisa L.

    2008-01-01

    This study examined the relationship between intimate partner violence and adult attachment in a sample of 70 couples. The attachment style of each partner and the interaction of the partners' attachment styles were examined as predictors of intimate partner violence. Additional analyses were conducted to examine violence reciprocity and to…

  16. Adamantyl-Substituted Retinoid-Derived Molecules That Interact with the Orphan Nuclear Receptor Small Heterodimer Partner: Effects of Replacing the 1-Adamantyl or Hydroxyl Group on Inhibition of Cancer Cell Growth, Induction of Cancer Cell Apoptosis, and Inhibition of Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase-2 Activity

    PubMed Central

    Dawson, Marcia I.; Xia, Zebin; Jiang, Tao; Ye, Mao; Fontana, Joseph A.; Farhana, Lulu; Patel, Bhaumik; Xue, Li Ping; Bhuiyan, Mohammad; Pellicciari, Roberto; Macchiarulo, Antonio; Nuti, Roberto; Zhang, Xiao-Kun; Han, Young-Hoon; Tautz, Lutz; Hobbs, Peter D.; Jong, Ling; Waleh, Nahid; Chao, Wan-ru; Feng, Gen-Sheng; Pang, Yuhong; Su, Ying

    2014-01-01

    (E)-4-[3-(1-Adamantyl)-4′-hydroxyphenyl]-3-chlorocinnamic acid (3-Cl-AHPC) induces the cell-cycle arrest and apoptosis of leukemia and cancer cells. Studies demonstrated that 3-Cl-AHPC bound to the atypical orphan nuclear receptor small heterodimer partner (SHP). Although missing a DNA-binding domain, SHP heterodimerizes with the ligand-binding domains of other nuclear receptors to repress their abilities to induce or inhibit gene expression. 3-Cl-AHPC analogues having the 1-adamantyl and phenolic hydroxyl pharmacophoric elements replaced with isosteric groups were designed, synthesized, and evaluated for their inhibition of proliferation and induction of human cancer cell apoptosis. Structure–anticancer activity relationship studies indicated the importance of both groups to apoptotic activity. Docking of 3-Cl-AHPC and its analogues to an SHP computational model that was based on the crystal structure of ultraspiracle complexed with 1-stearoyl-2-palmitoylglycero-3-phosphoethanolamine suggested why these 3-Cl-AHPC groups could influence SHP activity. Inhibitory activity against Src homology 2 domain-containing protein tyrosine phosphatase 2 (Shp-2) was also assessed. The most active Shp-2 inhibitor was found to be the 3′-(3,3-dimethylbutynyl) analogue of 3-Cl-AHPC. PMID:18759424

  17. Partner selection in the mycorrhizal mutualism.

    PubMed

    Werner, Gijsbert D A; Kiers, E Toby

    2015-03-01

    Partner selection in the mycorrhizal symbiosis is thought to be a key factor stabilising the mutualism. Both plant hosts and mycorrhizal fungi have been shown to preferentially allocate resources to higher quality partners. This can help maintain underground cooperation, although it is likely that different plant species vary in the spatial precision with which they can select partners. Partner selection in the mycorrhizal symbiosis is presumably context-dependent and can be mediated by factors like (relative) resource abundance and resource fluctuations, competition among mycorrhizas, arrival order and cultivation history. Such factors complicate our current understanding of the importance of partner selection and its effectiveness in stimulating mutualistic cooperation. PMID:25421912

  18. Maternal Re-Partnering and New-Partner Fertility: Associations with Nonresident Father Investments in Children

    PubMed Central

    Berger, Lawrence M.; Cancian, Maria; Meyer, Daniel R.

    2011-01-01

    Research suggests that paternal re-partnering and new-partner fertility are associated with decreased nonresident father investments in children. Few studies, however, have examined the influence of maternal re-partnering and new-partner births on nonresident father investments. We use data from the National Longitudinal Survey of Youth to examine associations of maternal re-partnering (through cohabitation or marriage with a new partner) and new-partner births with nonresident father visitation and child support payments. Results suggest that maternal re-partnering is associated with a decrease in both yearly father-child contact and child support received by the mother. New-partner fertility for mothers who are co-residing with a partner is associated with an additional decrease in monthly father-child contact, but does not have an additional influence on yearly father-child contact or child support receipt. PMID:22581998

  19. Depth Profiling of N and C in Ion Implanted ZnO and Si Using Deuterium Induced Nuclear Reaction Analysis

    SciTech Connect

    Kennedy, John; Murmu, Peter; Markwitz, Andreas

    2008-11-03

    Nuclear Reaction Analysis (NRA) with deuteron ion beams has been used to probe for ion implanted nitrogen and carbon with high sensitivity in zinc oxide and silicon single crystals. The ion implanted N was measured using 1.4 MeV deuteron ion beams and was found to be in agreement with calculated values. The limit of detection for N in ZnO is 8x10{sup 14} ions cm{sup -2}. Raman measurements of the ion implanted samples showed three additional modes at 275, 504, and 644 cm{sup -1} compared to the un-implanted ZnO crystals. The NRA and Raman results provided information on the N concentration, depth distribution, and structural changes that occur in dependence on the nitrogen ion fluences. The deuterium induced {sup 12}C(d,p){sup 13}C reaction was used to measure the carbon impurity/dose in ion implanted silicon. It was found that the use of a large cold shield (liquid nitrogen trap) in the ion implanter chamber greatly reduces the amount of carbon impurity on the surface of ion implanted silicon. Various implantations with N{sub 2}, O{sub 2}, NO, NO{sub 2} and Pb ions were performed with and without cooling of the liquid nitrogen trap. Simultaneous detection of ppm-level concentrations of {sup 12}C, {sup 16}O and {sup 14}N enables highly sensitive measurement of impurities that may be incorporated during the fabrication process, transport of the samples and/or storage of the samples in air.

  20. Profiles of nuclear and mitochondrial encoded mRNAs in developing and quiescent embryos of Artemia franciscana.

    PubMed

    Hardewig, I; Anchordoguy, T J; Crawford, D L; Hand, S C

    1996-05-24

    Embryos of the brine shrimp Artemia franciscana are able to withstand long bouts of environmental anoxia by entering a quiescent state during which metabolism is greatly depressed. Recent evidence supports a global arrest of protein synthesis during quiescence. In this study we measured the amounts of mRNA for a mitochondrial-encoded subunit of cytochrome c oxidase (COX I) and for nuclear-encoded actin during aerobic development, anaerobiosis, and aerobic acidosis (artificial quiescence imposed by intracellular acidification under aerobic conditions). The levels of both COX I and actin transcripts increased significantly during aerobic development. COX I mRNA levels were tightly correlated with previous measures of COX catalytic activity, which suggests that COX synthesis could be regulated by message concentration during aerobic development. The ontogenetic increase for these mRNAs was blocked by anoxia and aerobic acidosis. Importantly, the levels of COX I and actin mRNA did not decline appreciably during the 6 h bouts of quiescence, even though protein synthesis is acutely arrested by these same treatments. Thus, the constancy of mRNA levels during quiescence indicate that reduced protein synthesis is not caused by message limitation, but rather, is likely controlled at the translational level. One advantage of this regulatory mechanism is the conservation of mRNA molecules during quiescence, which would potentially favor a quick resumption of translation as soon as oxygen is returned to the embryos. Finally, because anoxia and aerobic acidosis are both characterized by acidic intracellular pH, the reduction in pH may serve, directly or indirectly, as one signal regulating levels of mRNA in this embryo during quiescence. PMID:8817476

  1. The Profile of Immune Modulation by Cannabidiol (CBD) Involves Deregulation of Nuclear Factor of Activated T Cells (NFAT)

    PubMed Central

    Kaplan, Barbara L. F.; Springs, Alison E. B.; Kaminski, Norbert E.

    2009-01-01

    Cannabidiol (CBD) is a cannabinoid compound derived from Cannabis Sativa that does not possess high affinity for either the CB1 or CB2 cannabinoid receptors. Similar to other cannabinoids, we demonstrated previously that CBD suppressed interleukin-2 (IL-2) production from phorbol ester plus calcium ionophore (PMA/Io)-activated murine splenocytes. Thus, the focus of the present studies was to further characterize the effect of CBD on immune function. CBD also suppressed IL-2 and interferon-γ (IFN-γ) mRNA expression, proliferation, and cell surface expression of the IL-2 receptor alpha chain, CD25. While all of these observations support the fact that CBD suppresses T cell function, we now demonstrate that CBD suppressed IL-2 and IFN-γ production in purified splenic T cells. CBD also suppressed activator protein-1 (AP-1) and nuclear factor of activated T cells (NFAT) transcriptional activity, which are critical regulators of IL-2 and IFN-γ. Furthermore, CBD suppressed the T cell-dependent anti-sheep red blood cell immunoglobulin M antibody forming cell (anti-sRBC IgM AFC) response. Finally, using splenocytes derived from CB1-/-/CB2-/- mice, it was determined that suppression of IL-2 and IFN-γ and suppression of the in vitro anti-sRBC IgM AFC response occurred independently of both CB1 and CB2. However, the magnitude of the immune response to sRBC was significantly depressed in CB1-/-/CB2-/- mice. Taken together, these data suggest that CBD suppresses T cell function and that CB1 and/or CB2 play a critical role in the magnitude of the in vitro anti-sRBC IgM AFC response. PMID:18656454

  2. To punish or to leave: distinct cognitive processes underlie partner control and partner choice behaviors.

    PubMed

    Martin, Justin W; Cushman, Fiery

    2015-01-01

    When a cooperative partner defects, at least two types of response are available: Punishment, aimed at modifying behavior, and ostracism, aimed at avoiding further social interaction with the partner. These options, termed partner control and partner choice, have been distinguished at behavioral and evolutionary levels. However, little work has compared their cognitive bases. Do these disparate behaviors depend on common processes of moral evaluation? Specifically, we assess whether they show identical patterns of dependence on two key dimensions of moral evaluation: A person's intentions, and the outcomes that they cause. We address this issue in a "trembling hand" economic game. In this game, an allocator divides a monetary stake between themselves and a responder based on a stochastic mechanism. This allows for dissociations between the allocator's intent and the actual outcome. Responders were either given the opportunity to punish or reward the allocator (partner control) or to switch to a different partner for a subsequent round of play (partner choice). Our results suggest that partner control and partner choice behaviors are supported by distinct underlying cognitive processes: Partner control exhibits greater sensitivity to the outcomes a partner causes, while partner choice is influenced almost exclusively by a partner's intentions. This cognitive dissociation can be understood in light of the unique adaptive functions of partner control and partner choice. PMID:25915550

  3. Results of joint processing of data on nuclear and chemical explosions recorded on the long-range Quartz profile (Murmansk-Kyzyl)

    NASA Astrophysics Data System (ADS)

    Pavlenkova, G. A.; Pavlenkova, N. I.

    2008-04-01

    The long-range seismic profile Quartz, measured by the GEON Center (Ministry of Geology of the USSR), crosses a few large geostructures: the East European platform, Timan-Pechora plate, Northern Urals, West Siberian plate (WSP), and Altai. Observations of nuclear and chemical explosions were conducted on the profile. Joint processing of records from sources of both types provided detailed structures of the crust and upper mantle. They have confirmed the known patterns in the structure of these shells of the Earth and revealed new ones. Mountain roots are observed beneath the Urals and Altai, and areas of a higher heat flow are matched by lower velocity zones in the upper mantle. Moreover, it is shown that the Timan-Pechora plate is characterized by a two-layer crust untypical of other young plates of central Eurasia and the upper mantle has the same velocities beneath the ancient East European platform and the young Altai orogen. It is also shown that the vast region including the Timan-Pechora plate, Urals, and WSP is bounded on both sides by deep faults in the upper mantle dipping toward the center of Western Siberia. A few nearly continuous reflectors traceable in the upper mantle are represented by thin-layered heterogeneous beds. The largest horizontal heterogeneity is observed in the upper 100-km layer, often underlain by a lower velocity zone. The asthenosphere, as a layer of lower seismic velocities at the depth of a possible solidus (200 250 km), has not been revealed. The latter is evidently a feature specific to inner parts of the Eurasian continent; in marginal regions, e.g., in Western Europe, the asthenospheric layer is identified almost ubiquitously.

  4. BDE-47 causes developmental retardation with down-regulated expression profiles of ecdysteroid signaling pathway-involved nuclear receptor (NR) genes in the copepod Tigriopus japonicus.

    PubMed

    Hwang, Dae-Sik; Han, Jeonghoon; Won, Eun-Ji; Kim, Duck-Hyun; Jeong, Chang-Bum; Hwang, Un-Ki; Zhou, Bingsheng; Choe, Joonho; Lee, Jae-Seong

    2016-08-01

    2,2',4,4'-Tetrabromodiphenyl ether (BDE-47) is a persistent organic pollutant (POP) in marine environments. Despite its adverse effects (e.g. developmental retardation) in ecdysozoa, the effects of BDE-47 on transcription of ecdysteroid signaling pathway-involved-nuclear receptor (NR) genes and metamorphosis-related genes have not been examined in copepods. To examine the deleterious effect of BDE-47 on copepod molting and metamorphosis, BDE-47 was exposed to the harpacticoid copepod Tigriopus japonicus, followed by monitoring developmental retardation and transcriptional alteration of NR genes. The developmental rate was significantly inhibited (P<0.05) in response to BDE-47 and the agricultural insecticide gamma-hexachlorocyclohexane. Conversely, the ecdysteroid agonist ponasterone A (PoA) led to decreased molting and metamorphosis time (P<0.05) from the nauplius stage to the adult stage. In particular, expression profiles of all NR genes were the highest at naupliar stages 5-6 except for SVP, FTZ-F1, and HR96 genes. Nuclear receptor USP, HR96, and FTZ-F1 genes also showed significant sex differences (P<0.05) in gene expression levels over different developmental stages, indicating that these genes may be involved in vitellogenesis. NR gene expression patterns showed significant decreases (P<0.05) in response to BDE-47 exposure, implying that molting and metamorphosis retardation is likely associated with NR gene expression. In summary, BDE-47 leads to molting and metamorphosis retardation and suppresses transcription of NR genes. This information will be helpful in understanding the molting and metamorphosis delay mechanism in response to BDE-47 exposure. PMID:27337698

  5. Computational protein design suggests that human PCNA-partner interactions are not optimized for affinity.

    PubMed

    Fridman, Yearit; Gur, Eyal; Fleishman, Sarel J; Aharoni, Amir

    2013-02-01

    Increasing the affinity of binding proteins is invaluable for basic and applied biological research. Currently, directed protein evolution experiments are the main approach for generating such proteins through the construction and screening of large mutant libraries. Proliferating cell nuclear antigen (PCNA) is an essential hub protein that interacts with many different partners to tightly regulate DNA replication and repair in all eukaryotes. Here, we used computational design to generate human PCNA mutants with enhanced affinity for several different partners. We identified double mutations in PCNA, outside the main partner binding site, that were predicted to increase PCNA-partner binding affinities compared to the wild-type protein by forming additional hydrophobic interactions with conserved residues in the PCNA partners. Affinity increases were experimentally validated with four different PCNA partners, demonstrating that computational design can reveal unexpected regions where affinity enhancements in natural systems are possible. The designed PCNA mutants can be used as a valuable tool for further examination of the regulation of PCNA-partner interactions during DNA replication and repair both in vitro and in vivo. More broadly, the ability to engineer affinity increases toward several PCNA partners suggests that interaction affinity is not an evolutionarily optimized trait of this system. PMID:23011891

  6. Depth profiles of radioactive cesium in soil using a scraper plate over a wide area surrounding the Fukushima Dai-ichi Nuclear Power Plant, Japan.

    PubMed

    Matsuda, Norihiro; Mikami, Satoshi; Shimoura, Susumu; Takahashi, Junko; Nakano, Masakazu; Shimada, Kiyotaka; Uno, Kiichiro; Hagiwara, Shigetomo; Saito, Kimiaki

    2015-01-01

    During the Fukushima Dai-ichi Nuclear Power Plant (NPP) accident, radioactive cesium was released in the environment and deposited on the soils. Depth profiles of radioactive cesium in contaminated soils provide useful information not only for radiation protection and decontamination operations but also for geoscience and radioecology studies. Soil samples were collected using a scraper plate three times between December 2011 and December 2012 at 84 or 85 locations within a 100-km radius of the Fukushima Dai-ichi NPP. In most of the obtained radioactive cesium depth profiles, it was possible to fit the concentration to a function of mass depth as either an exponential or hyperbolic secant function. By using those functions, following three parameters were estimated: (i) relaxation mass depth β (g cm(-2)), (ii) effective relaxation mass depth βeff (g cm(-2)), which is defined for a hyperbolic secant function as the relaxation mass depth of an equivalent exponential function giving the same air kerma rate at 1 m above the ground as the inventory, and (iii) 1/10 depth L1/10 (cm), at which the soil contains 90% of the inventory. The average β value (wet weight) including ones by hyperbolic secant function in December 2012, was 1.29 times higher than that in December 2011. In fact, it was observed that depth profiles at some study sites deviated from the typical exponential distributions over time. These results indicate the gradual downward migration of radioactive cesium in the soils. The L1/10 values in December 2012 were summarized and presented on a map surrounding the Fukushima Dai-ichi NPP, and the average value of L1/10 was 3.01 cm (n = 82) at this time. It was found that radioactive cesium remained within 5 cm of the ground surface at most study sites (71 sites). The sech function can also be used to estimate the downward migration rate V (kg m(-2) y(-1)). The V values in December 2012 (n = 25) were in good agreement with those found by a

  7. Collaborative vaccine development: partnering pays.

    PubMed

    Ramachandra, Rangappa

    2008-01-01

    Vaccine development, supported by infusions of public and private venture capital, is re-entering a golden age as one of the fastest growing sectors in the life-sciences industry. Demand is driven by great unmet need in underdeveloped countries, increased resistance to current treatments, bioterrorism, and for prevention indications in travelers, pediatric, and adult diseases. Production systems are becoming less reliant on processes such as egg-based manufacturing, while new processes can help to optimize vaccines. Expeditious development hinges on efficient study conduct, which is greatly enhanced through research partnerships with specialized contract research organizations (CROs) that are licensed and knowledgeable in the intricacies of immunology and with the technologic and scientific foundation to support changing timelines and strategies inherent to vaccine development. The CRO often brings a more objective assessment for probability of success and may offer alternative development pathways. Vaccine developers are afforded more flexibility and are free to focus on innovation and internal core competencies. Functions readily outsourced to a competent partner include animal model development, safety and efficacy studies, immunotoxicity and immunogenicity, dose response studies, and stability and potency testing. These functions capitalize on the CRO partner's regulatory and scientific talent and expertise, and reduce infrastructure expenses for the vaccine developer. Successful partnerships result in development efficiencies, elimination or reduced redundancies, and improved time to market. Keys to success include honest communications, transparency, and flexibility. PMID:18388488

  8. Semiconductor foundry, lithography, and partners

    NASA Astrophysics Data System (ADS)

    Lin, Burn J.

    2002-07-01

    The semiconductor foundry took off in 1990 with an annual capacity of less than 0.1M 8-inch-equivalent wafers at the 2-mm node. In 2000, the annual capacity rose to more than 10M. Initially, the technology practiced at foundries was 1 to 2 generations behind that at integrated device manufacturers (IDMs). Presently, the progress in 0.13-mm manufacturing goes hand-in-hand with any of the IDMs. There is a two-order of magnitude rise in output and the progress of technology development outpaces IDMs. What are the reasons of the success? Is it possible to sustain the pace? This paper shows the quick rise of foundries in capacity, sales, and market share. It discusses the their uniqueness which gives rise to advantages in conjunction with challenges. It also shows the role foundries take with their customer partners and supplier partners, their mutual dependencies, as well as expectations. What role then does lithography play in the foundries? What are the lithographic challenges to sustain the pace of technology? The experience of technology development and transfer, at one of the major foundries, is used to illustrate the difficulties and progresses made. Looking into the future, as semiconductor manufacturing will become even more expensive and capital investment more prohibitive, we will make an attempt to suggest possible solutions.

  9. Intimate Partner Violence among California Couples: Multilevel Analysis of Environmental and Partner Risk Factors

    PubMed Central

    Cunradi, Carol B.; Todd, Michael; Mair, Christina; Remer, Lillian

    2014-01-01

    This study assessed the extent to which environmental (Census block-group alcohol outlet density, neighborhood demographic characteristics) and partner risk factors (e.g., hazardous drinking, psychosocial characteristics) contribute to the likelihood of intimate partner violence among 1,753 couples residing in 50 medium-to-large California cities. Multilevel logistic regression models were used to analyze the role of alcohol outlets (off-premise outlets, bars/pubs and restaurants), neighborhood demographic characteristics, and partner risk factors in relation to male-to-female partner violence (MFPV) and female-to-male partner violence (FMPV) risk. Approximately 12% of couples reported past-year partner violence. Results showed that none of the environmental measures were related to MFPV or FMPV. Male partner's impulsivity and each partner's adverse childhood experiences were associated with MFPV risk. Risk factors for FMPV were male partner's impulsivity and frequency of intoxication and female partner's adverse childhood experiences. Individual/couple characteristics appear to be the most salient IPV risk factors. The male partner's heavy drinking may lead to negative partner/spousal interactions that result in FMPV. The male partner's impulsivity, and each partner's adverse childhood experiences, may potentiate couple conflict and result in aggression. Interventions that target prevention of family dysfunction during childhood may help reduce interpersonal violence in adulthood. PMID:24812578

  10. To Punish or to Leave: Distinct Cognitive Processes Underlie Partner Control and Partner Choice Behaviors

    PubMed Central

    Martin, Justin W.; Cushman, Fiery

    2015-01-01

    When a cooperative partner defects, at least two types of response are available: Punishment, aimed at modifying behavior, and ostracism, aimed at avoiding further social interaction with the partner. These options, termed partner control and partner choice, have been distinguished at behavioral and evolutionary levels. However, little work has compared their cognitive bases. Do these disparate behaviors depend on common processes of moral evaluation? Specifically, we assess whether they show identical patterns of dependence on two key dimensions of moral evaluation: A person’s intentions, and the outcomes that they cause. We address this issue in a “trembling hand” economic game. In this game, an allocator divides a monetary stake between themselves and a responder based on a stochastic mechanism. This allows for dissociations between the allocator’s intent and the actual outcome. Responders were either given the opportunity to punish or reward the allocator (partner control) or to switch to a different partner for a subsequent round of play (partner choice). Our results suggest that partner control and partner choice behaviors are supported by distinct underlying cognitive processes: Partner control exhibits greater sensitivity to the outcomes a partner causes, while partner choice is influenced almost exclusively by a partner’s intentions. This cognitive dissociation can be understood in light of the unique adaptive functions of partner control and partner choice. PMID:25915550

  11. Slow Magic Angle Sample Spinning: A Non- or Minimally Invasive Method for High- Resolution 1H Nuclear Magnetic Resonance (NMR) Metabolic Profiling

    SciTech Connect

    Hu, Jian Z.

    2011-05-01

    High resolution 1H magic angle spinning nuclear magnetic resonance (NMR), using a sample spinning rate of several kHz or more (i.e., high resolution-magic angle spinning (hr-MAS)), is a well established method for metabolic profiling in intact tissues without the need for sample extraction. The only shortcoming with hr-MAS is that it is invasive and is thus unusable for non-destructive detections. Recently, a method called slow-MAS, using the concept of two dimensional NMR spectroscopy, has emerged as an alternative method for non- or minimal invasive metabolomics in intact tissues, including live animals, due to the slow or ultra-slow-sample spinning used. Although slow-MAS is a powerful method, its applications are hindered by experimental challenges. Correctly designing the experiment and choosing the appropriate slow-MAS method both require a fundamental understanding of the operation principles, in particular the details of line narrowing due to the presence of molecular diffusion. However, these fundamental principles have not yet been fully disclosed in previous publications. The goal of this chapter is to provide an in depth evaluation of the principles associated with slow-MAS techniques by emphasizing the challenges associated with a phantom sample consisting of glass beads and H2O, where an unusually large magnetic susceptibility field gradient is obtained.

  12. Targeted disruption of the mouse Lipoma Preferred Partner gene

    SciTech Connect

    Vervenne, Hilke B.V.K.; Crombez, Koen R.M.O.; Delvaux, Els L.; Janssens, Veerle; Ven, Wim J.M. van de Petit, Marleen M.R.

    2009-02-06

    LPP (Lipoma Preferred Partner) is a zyxin-related cell adhesion protein that is involved in the regulation of cell migration. We generated mice with a targeted disruption of the Lpp gene and analysed the importance of Lpp for embryonic development and adult functions. Aberrant Mendelian inheritance in heterozygous crosses suggested partial embryonic lethality of Lpp{sup -/-} females. Fertility of Lpp{sup -/-} males was proven to be normal, however, females from Lpp{sup -/-} x Lpp{sup -/-} crosses produced a strongly reduced number of offspring, probably due to a combination of female embryonic lethality and aberrant pregnancies. Apart from these developmental and reproductive abnormalities, Lpp{sup -/-} mice that were born reached adulthood without displaying any additional macroscopic defects. On the other hand, Lpp{sup -/-} mouse embryonic fibroblasts exhibited reduced migration capacity, reduced viability, and reduced expression of some Lpp interaction partners. Finally, we discovered a short nuclear form of Lpp, expressed mainly in testis via an alternative promoter.

  13. Intimate partner violence in African American women.

    PubMed

    Campbell, Doris Williams; Sharps, Phyllis W; Gary, Faye A; Campbell, Jacquelyn C; Lopez, Loretta M

    2002-01-01

    Violence against African American women, specifically intimate partner abuse, has a significant impact on their health and well being. Intimate partner femicide and near fatal intimate partner femicide are the major causes of premature death and disabling injuries for African American women. Yet, despite this, there is a paucity of research and interventions specific and culturally relevant for these women. This article focuses on issues relevant to intimate partner violence and abuse against African American women by examining existing empirical studies of prevalence and health outcomes of intimate partner violence against women in general, plus what limited research there is about African American women, specifically. It includes a discussion of specific recommendations for research, practice, education, and policy to reduce and prevent intimate partner violence against African American women. PMID:12044219

  14. Putting intimate partner violence on your radar.

    PubMed

    Collett, DeShana; Bennett, Tamara

    2015-10-01

    Intimate partner violence is a preventable health problem that affects more than 12 million people in the United States each year. Those affected can be of any sex, race, ethnicity, socioeconomic status, religion, education level, or sexual orientation. All clinicians should screen for intimate partner violence as part of the routine history and physical examination. This article describes the dynamics of intimate partner violence and the 2013 screening guidelines from the US Preventive Services Task Force. PMID:26352870

  15. Screening for Intimate Partner Violence.

    PubMed

    Paterno, Mary T; Draughon, Jessica E

    2016-05-01

    Intimate partner violence (IPV) is a serious concern for women that is associated with significant adverse health effects. Routine screening for IPV is recommended, but there are many barriers to screening that have been identified by providers, including discomfort, lack of training, and not knowing how to respond to a positive screen. This article reviews IPV screening and appropriate techniques for responding to a positive screen. IPV screening best practices include using a systematic protocol, developing a screening script, using a validated screening tool, and considerations for privacy and mandatory reporting. Responding to a positive screen should include acknowledging the experience, asking if the woman desires help, offering support and referrals, encouraging safety planning, and completing additional assessments to determine level of danger and to identify any comorbidities. Using these techniques along with therapeutic communication may increase IPV identification and create an environment in which women feel empowered to get help. PMID:26990666

  16. ECHO Status for International Partners

    NASA Technical Reports Server (NTRS)

    Weinstein, Beth; Lubelczyk, Jeff

    2006-01-01

    The EOS Clearinghouse (ECHO) is a clearinghouse of spatial and temporal metadata, inclusive of NASA's Distributed Active Archive Center (DAAC) data holdings, that enables the science community to more easily exchange NASA data and information. Currently, ECHO has metadata descriptors for over 55 million individual data granules and 13 million browse images. The majority of ECHO's holdings come directly from data held in the NASA DAACs. The science disciplines and domains represented in ECHO are diverse and include metadata for all of NASA's Science Focus Area data. As middleware for a service-oriented enterprise, ECHO offers access to its capabilities through a set of publicly available Application Program Interfaces (APIs). More information about ECHO is available at http://eos.nasa.gov.echo. The presentation will discuss the status of the ECHO Partners, holdings, and activities, including the transition from the EOS Data Gateway to the Warehouse Inventory Search Tool (WIST)

  17. Health Problems of Partner Violence Victims

    PubMed Central

    Hines, Denise A.; Douglas, Emily M.

    2014-01-01

    Background National population-based studies show that 40%–50% of physical partner violence victims in a 1-year time period are men. However, studies assessing the health concerns related to partner violence victimization tend to focus on women, and none have assessed the health of male physical partner violence victims who sought help for their victimization. Purpose To understand men’s mental and physical health concerns that may be related to partner violence victimization. Methods In 2012–2013, two samples of men—611 physical partner violence victims who sought help and 1,601 men from a population-based sample – completed online questionnaires on their demographics, various types of partner violence victimization, physical health, mental health, and other risks. Data were analyzed using logistic regression, log binomial models, and robust Poisson models in 2013. Results In comparison to the population-based sample of men, male partner violence victims who sought help had significantly poorer health, particularly with regard to post-traumatic stress disorder, depression, high blood pressure, sexually transmitted diseases, and asthma. These differences remained after controlling for sample differences in demographics, substance use, previous traumatic exposure, and social support. Conclusions Practitioners should assess for health problems among partner violence victims and for partner violence victimization among men presenting with health problems. PMID:25442232

  18. Oligomerization and conformation change in solutions of calf lens gamma II-crystallin. Results from 1/T1 nuclear magnetic relaxation dispersion profiles.

    PubMed Central

    Koenig, S H; Beaulieu, C F; Brown, R D; Spiller, M

    1990-01-01

    From analyses of the magnetic field dependence of 1/T1 (nuclear magnetic relaxation dispersion [NMRD] profiles) of water protons in solutions of highly purified calf lens gamma II-crystallin, we find that monomers form oligomers at relatively low concentrations, which increase in size with increasing concentration and decreasing temperature. At approximately 16% by volume and -4 degrees C, the mean oligomeric molecular weight is approximately 120-fold greater than the monomeric value of 20 kD. Below this concentration, there is no indication of any substantive change in conformation of the monomeric subunits. At higher concentrations, the tertiary structure of the monomer appears to reconfigure rather abruptly, but reversibly, as evidenced by the appearance of spectra-like 14N peaks in the NMRD profiles. The magnitudes of these peaks, known to arise from cross-relaxation of water protons through access to amide (NH) moieties of the protein backbone, indicate that the high concentration conformation is not compact, but open and extended in a manner that allows enhanced interaction with solvent. The data are analogous to those found for homogenates of calf and chicken lens (Beaulieu, C. F., J. I. Clark, R. D. Brown III, M. Spiller, and S. H. Koenig. 1988. Magn. Reson. Med. 8:47-57; Beaulieu, C. F., R. D. Brown III, J. I. Clark, M. Spiller, and S. H. Koenig. 1989. Magn. Reson. Med. 10:62-72). This unusually large dependence of oligomeric size and conformation on concentration in the physiological range is suggested as the mechanism by which osmotic equilibrium is maintained, at minimal metabolic expense, in the presence of large gradients of protein concentration in the lens in vivo (cf Vérétout and Tardieu, 1989. Eur. Biophys. J. 17:61-68). Finally, the results of the NMRD data provide a ready explanation of the low temperature phase transition, and "cold-cataract" separation of phases, observed in gamma II-crystallin solutions; we suggest that the phases that

  19. Vertical distribution and temporal changes of 137Cs in soil profiles under various land uses after the Fukushima Dai-ichi Nuclear Power Plant accident.

    PubMed

    Takahashi, Junko; Tamura, Kenji; Suda, Tomoya; Matsumura, Ryo; Onda, Yuichi

    2015-01-01

    We monitored the vertical distribution of (137)Cs in soil profiles under eight different land uses for the 2 y after the Fukushima Dai-ichi Nuclear Power Plant accident, and discussed the temporal changes in the early-stage of the migration and the determinants of the initial distribution. The soil samples were collected for four surveys using a scraper plate at each study site, which consisted of three forests (mixed forest, mature cedar, and young cedar), two grasslands (pasture and meadow) and three abandoned agricultural fields (farm land, tobacco field, and paddy field). The land use patterns have a large influence on some soil properties and the migration processes of (137)Cs above ground, resulting in different distribution of (137)Cs in those soil profiles. Specifically, the secondary deposition of (137)Cs from the coniferous canopy, retention of (137)Cs by litter layer, and the homogenization of (137)Cs concentrations in surface soil by natural soil mixing such as the disturbance by cattle grazing, roots growing and the formation of needle ice were important to cause redistribution of the deposited (137)Cs. Only in the paddy field, the (137)Cs inventory in subsurface soils (5-10 cm) gradually increased and comprised 26% of the total (137)Cs in 2 y, showing the downward migration of (137)Cs to subsurface soil. In the other sites, it was considered that (137)Cs were strongly adsorbed by soil particles and rarely migrated downward as soluble form. Vertical distributions during the first survey were able to be used as the initial distributions and were well fitted to the exponential equation. The distribution parameters α (relaxation depth) and β (relaxation mass depth), calculated by the exponential equation were correlated with RIP (r = -0.806, p < 0.05), macro pore (r = 0.651, p = 0.11), and dispersible fine particle content (r = 0.856, p < 0.05). It indicated that the initial distribution would be influenced by the Cs fixation ability of

  20. Communication Partners' Journey through Their Partner's Hearing Impairment

    PubMed Central

    Manchaiah, Vinaya K. C.; Stephens, Dafydd; Lunner, Thomas

    2013-01-01

    The objective of this study was to further develop the Ida Institute model on communication partners' (CPs) journey through experiences of person with hearing impairment (PHI), based on the perspectives of CPs. Nine CPs of hearing aid users participated in this study, recruited through the Swansea hearing impaired support group. Semi-structured interviews were conducted, the data were analysed using qualitative thematic analysis and presented with the use of process mapping approach. Seven main phases were identified in the CP journey which includes: (1) contemplation, (2) awareness, (3) persuasion, (4) validation, (5) rehabilitation, (6) adaptation, and (7) resolution. The Ida Institute model (based on professionals' perspective) was compared with the new template developed (based on CPs' perspectives). The results suggest some commonalities and differences between the views of professionals and CPs. A new phase, adaptation, was identified from CPs reported experiences, which was not identified by professionals in the Ida Institute model. The CP's journey model could be a useful tool during audiological enablement/rehabilitation sessions to promote discussion between the PHI and the CP. In addition, it can be used in the training of hearing healthcare professionals. PMID:23533422

  1. Quantitative 1H Nuclear Magnetic Resonance Metabolite Profiling as a Functional Genomics Platform to Investigate Alkaloid Biosynthesis in Opium Poppy1[W

    PubMed Central

    Hagel, Jillian M.; Weljie, Aalim M.; Vogel, Hans J.; Facchini, Peter J.

    2008-01-01

    Opium poppy (Papaver somniferum) produces a diverse array of bioactive benzylisoquinoline alkaloids and has emerged as a versatile model system to study plant alkaloid metabolism. The plant is widely cultivated as the only commercial source of the narcotic analgesics morphine and codeine. Variations in plant secondary metabolism as a result of genetic diversity are often associated with perturbations in other metabolic pathways. As part of a functional genomics platform, we used 1H nuclear magnetic resonance (NMR) metabolite profiling for the analysis of primary and secondary metabolism in opium poppy. Aqueous and chloroform extracts of six different opium poppy cultivars were subjected to chemometric analysis. Principle component analysis of the 1H NMR spectra for latex extracts clearly distinguished two varieties, including a low-alkaloid variety and a high-thebaine, low-morphine cultivar. Distinction was also made between pharmaceutical-grade opium poppy cultivars and a condiment variety. Such phenotypic differences were not observed in root extracts. Loading plots confirmed that morphinan alkaloids contributed predominantly to the variance in latex extracts. Quantification of 34 root and 21 latex metabolites, performed using Chenomx NMR Suite version 4.6, showed major differences in the accumulation of specific alkaloids in the latex of the low-alkaloid and high-thebaine, low-morphine varieties. Relatively few differences were found in the levels of other metabolites, indicating that the variation was specific for alkaloid metabolism. Exceptions in the low-alkaloid cultivar included an increased accumulation of the alkaloid precursor tyramine and reduced levels of sucrose, some amino acids, and malate. Real-time polymerase chain reaction analysis of 42 genes involved in primary and secondary metabolism showed differential gene expression mainly associated with alkaloid biosynthesis. Reduced alkaloid levels in the condiment variety were associated with the

  2. Involving Support Partners in Obesity Treatment

    ERIC Educational Resources Information Center

    Gorin, Amy; Phelan, Suzanne; Tate, Deborah; Sherwood, Nancy; Jeffery, Robert; Wing, Rena

    2005-01-01

    In this study, the authors examined whether the number or success of weight loss partners influences participants' outcomes in behavioral weight loss treatment. Overweight participants (n=109) assigned to an exercise intensive group in a larger trial were encouraged to invite up to 3 partners to attend treatment. Weight losses at 6, 12, and 18…

  3. Partners in Science. [CD-ROM].

    ERIC Educational Resources Information Center

    2000

    Partners in Science students, aided by community professionals, learn science by designing and conducting their own research. Partners in Science brings the community and schools closer together through a mentorship program. Scientists, in fields ranging from wildlife biology to space physics, are in frequent contact with classes and home-schooled…

  4. 77 FR 76380 - Partner's Distributive Share

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-28

    ... Internal Revenue Service 26 CFR Part 1 RIN 1545-BJ37 Partner's Distributive Share AGENCY: Internal Revenue... attributes of its partners in order to determine whether a partnership's allocations are substantial. However..., provided the partnership's assumptions are reasonable, allocations that would be substantial on the...

  5. Intimate Partner Violence in Older Women

    ERIC Educational Resources Information Center

    Bonomi, Amy E.; Anderson, Melissa L.; Reid, Robert J.; Carrell, David; Fishman, Paul A.; Rivara, Frederick P.; Thompson, Robert S.

    2007-01-01

    Purpose: We describe the prevalence, types, duration, frequency, and severity of intimate partner violence ("partner violence") in older women. Design and Methods: We randomly sampled a total of 370 English-speaking women (65 years of age and older) from a health care system to participate in a cross-sectional telephone interview. Using 5…

  6. The Relationship Talk: Assessing Partner Commitment

    ERIC Educational Resources Information Center

    Nelms, Bobbie Jo; Knox, David; Easterling, Beth

    2012-01-01

    "The talk" is culturally understood to mean a discussion whereby both partners in a relationship reveal their feelings about each other and their commitment to a future together. Typically, one partner feels a greater need to clarity the future and instigates "the talk." This study reports the analysis of a 15 item questionnaire completed by 211…

  7. Odd top partners at the LHC

    NASA Astrophysics Data System (ADS)

    Anandakrishnan, Archana; Collins, Jack H.; Farina, Marco; Kuflik, Eric; Perelstein, Maxim

    2016-04-01

    LHC searches for fermionic top partners T focus on three decay topologies: T →b W , T →t Z , and T →t h . However, top partners may carry new conserved quantum numbers that forbid these decays. The simplest possibility is a conserved parity, under which the top partner is odd and all SM states are even. In this case, decays of top partners may involve new particle-odd scalars, leading to signal topologies more commonly associated with supersymmetry, either with or without R -parity conservation. We study a simplified model in which this possibility is realized, and estimate the bounds on the top partner mass in this model implied by LHC searches for supersymmetry. We find that the bounds can be significantly weaker than in the conventional top partner decay scenario. For example, if the new parity is exact, a 500 GeV top partner is allowed as long as the lightest parity-odd scalar mass is between 325 and 500 GeV. The lower allowed top partner mass reduces the need for fine-tuning in the Higgs mass parameter, compared to the conventional decay scenario. We also present an explicit model, the oddest little Higgs, which exhibits this phenomenology.

  8. X (5568 ) and its partner states

    NASA Astrophysics Data System (ADS)

    Liu, Yan-Rui; Liu, Xiang; Zhu, Shi-Lin

    2016-04-01

    Stimulated by the recent observation of the X (5568 ), we study the X (5568 ) and its partners under the tetraquark scenario. In the framework of the color-magnetic interaction, we estimate the masses of the partner states of the X (5568 ) and discuss their decay pattern, which provides valuable information on the future experimental search of these states.

  9. Advice from working women with retired partners.

    PubMed

    Cooley, Eileen L; Adorno, Gail

    2016-01-01

    in the 21st century, as more women are employed full-time and couples increasingly share egalitarian values, more women continue employment after their partners have voluntarily retired. However, we know very little about the experiences of this growing population of women. We asked working women with retired partners to share their advice for other women who may face this developmental transition. Open-ended responses from 97 women were analyzed to identify pertinent issues and themes. Four primary content areas were identified: time management, division of household labor, financial planning, and communication. Communication between partners was both a topic of concern as well as the solution suggested to resolve conflicts or differences that may arise when women live with a retired partner. It is expected that future changes in the workforce and improvements in the gender balance within relationships will continue to impact experiences for working women with retired partners. PMID:26933760

  10. Teleportation with Multiple Accelerated Partners

    NASA Astrophysics Data System (ADS)

    Sagheer, A.; Hamdoun, H.; Metwally, N.

    2015-09-01

    As the current revolution in communication is underway, quantum teleportation can increase the level of security in quantum communication applications. In this paper, we present a quantum teleportation procedure that capable to teleport either accelerated or non-accelerated information through different quantum channels. These quantum channels are based on accelerated multi-qubit states, where each qubit of each of these channels represents a partner. Namely, these states are the W state, Greenberger-Horne-Zeilinger (GHZ) state, and the GHZ-like state. Here, we show that the fidelity of teleporting accelerated information is higher than the fidelity of teleporting non-accelerated information, both through a quantum channel that is based on accelerated state. Also, the comparison among the performance of these three channels shows that the degree of fidelity depends on type of the used channel, type of the measurement, and value of the acceleration. The result of comparison concludes that teleporting information through channel that is based on the GHZ state is more robust than teleporting information through channels that are based on the other two states. For future work, the proposed procedure can be generalized later to achieve communication through a wider quantum network.

  11. Intimate Partner Violence and Partner STI Notification Among Adolescent and Young Adult Family Planning Clinic Patients

    PubMed Central

    Decker, Michele R.; Miller, Elizabeth; McCauley, Heather L.; Tancredi, Daniel J.; Levenson, Rebecca R.; Waldman, Jeffrey; Schoenwald, Phyllis; Silverman, Jay G.

    2013-01-01

    Objectives Patient-initiated partner STI notification, i.e., patients informing their sexual partners of diagnosis, is a cornerstone of STI prevention. Growing evidence suggests that women exposed to intimate partner violence (IPV) may fear such notification, or face negative consequences in response to STI disclosure. The current study assessed associations of IPV with fear of partner STI notification, and experiences of partner STI notification, among adolescent and young adult female family planning clinic patients. Methods Females patients ages 16–29 years in five family planning clinics in Northern California (n=1282) participated in a cross-sectional survey. Results History of physical or sexual IPV was associated with fear of partner STI notification. Moreover, participants exposed to IPV were more likely to have partners say it was not from them or otherwise accuse them of cheating in response to STI notification. Such partners were less likely to seek indicated STI treatment or testing. Conclusions Current findings suggest that STI partner notification may be compromised by IPV. Clinical practices and policies to support effective partner STI notification should include IPV assessment, and provide mechanisms to address related fears concerning partner notification. PMID:21680673

  12. Male partner selectivity, romantic confidence, and media depictions of partner scarcity.

    PubMed

    Taylor, Laramie D

    2013-01-01

    An experiment was conducted to explore the effects of exposure to partner scarcity or abundance messages on men's partner selectivity, romantic confidence, and self-assessed attractiveness. Undergraduate male participants watched a soap opera narrative featuring either two men competing over one potential female partner (partner scarcity) or two women competing over one potential male partner (partner abundance). Relative to control subjects, watching either narrative reduced romantic confidence. Experimental condition also affected partner selectivity and self-assessed attractiveness, though both effects were moderated by endorsement of traditional masculine ideology. Viewing the abundance narrative resulted in greater selectivity and self-assessed attractiveness for men high in endorsement of traditional masculinity but diminished selectivity and self-assessed attractiveness for men low in endorsement of traditional masculine identity. PMID:23335697

  13. Sleep loss and partner violence victimization.

    PubMed

    Walker, Robert; Shannon, Lisa; Logan, T K

    2011-07-01

    Intimate partner violence victimization has been associated with serious health problems among women, including many disorders that involve sleep disturbances. However, there has been only limited examination of sleep duration among women with victimization experiences. A total of 756 women with a domestic violence order (DVO) against a male intimate partner were interviewed about their health, mental health, substance use, and partner violence victimization. Face-to-face interviews were conducted from February 2001 to November 2003 for data collection in three rural and one urban county representing different jurisdictional settings. Because the current analyses focused on understanding intimate partner victimization in the past year and associations with sleep disturbance, 147 participants were excluded for reporting a relationship with the DVO partner for less than 6 months in the past year. The final sample for this article was 609. The women reported an average of a little above 5.5 hours of sleep per night. For women in the current study, significant predictors of sleep disturbance included race, number of children, number of other symptoms of depression in the past 2 weeks excluding sleep criteria, number of other symptoms of PTSD in the past 2 weeks excluding sleep criteria, number of chronic physical health problems, and severity of physical violence by the DVO partner in the past year. Addressing short sleep duration among partner victims in health care settings might enhance safety planning and prevent the development of health/mental health problems that can arise from victimization. PMID:20587469

  14. Attitude and behavior changes among gay and bisexual men after use of rapid home HIV tests to screen sexual partners.

    PubMed

    Frasca, Timothy; Balan, Ivan; Ibitoye, Mobolaji; Valladares, Juan; Dolezal, Curtis; Carballo-Diéguez, Alex

    2014-05-01

    HIV testing can now be self-administered outside clinical settings through the purchase of home testing (HT) kits. Individuals also can use the kits to perform a test on a potential sexual partner prior to intercourse. We provided a 3-month supply of HT kits to men who reported multiple male partners and little or no condom use for anal intercourse. Participants used the test kits with partners in over 100 occasions. At the end of the study, approximately half of the participants described shifts in their attitudes and/or behaviors related to sexual risk. Reported changes included increased awareness of risk, increased discussion of STI/HIV safety measures, changes in partner choice and heightened consciousness of partner thinking. Easy access to HT kits may be a risk-reduction strategy for men with a high risk profile because their regular use could have an impact beyond the specific sexual encounter. PMID:24077975

  15. Partners in Leadership for Pearl River

    NASA Technical Reports Server (NTRS)

    2007-01-01

    Members of the 2007 class of Partners in Leadership toured NASA Stennis Space Center in Hancock County, Miss., on Jan. 11. They visited the center's B Test Stand, part of the center's rocket engine test complex. The Partners in Leadership training program is designed to teach Pearl River County leaders about their county's government, economic development, health and human services, history and arts, environment and education during a 10-month period. The program, sponsored by the Partners for Pearl River County, helps fulfill the mission of the economic and community development agency.

  16. Intimate partner violence in rural environments.

    PubMed

    Annan, Sandra L

    2008-01-01

    The purpose of this chapter is to review nursing and other research related to rural intimate partner violence. The author presents a review of research in the area of intimate partner violence in the rural setting. The findings indicate that there is limited nursing research related to intimate partner violence in rural communities. The review describes the prevalence and types of abuse, the rural service issues, and the consequences of battering. The chapter also discusses the health implications of violence in the rural setting. The author concludes with a presentation of a research agenda for nursing research in rural environments. PMID:18709747

  17. Screening for Intimate Partner Violence During Pregnancy

    PubMed Central

    Deshpande, Neha A; Lewis-O’Connor, Annie

    2013-01-01

    Intimate partner violence (IPV) is defined as an actual or threatened abuse by an intimate partner that may be physical, sexual, psychological, or emotional in nature. Each year approximately 1.5 million women in the United States report some form of sexual or physical assault by an intimate partner; it is estimated that approximately 324,000 women are pregnant when violence occurs. Pregnancy may present a unique opportunity to identify and screen for patients experiencing IPV. This article provides health care practitioners and clinicians with the most current valid assessment and screening tools for evaluating pregnant women for IPV. PMID:24920977

  18. Partnering with Families through Institutional Advancement.

    ERIC Educational Resources Information Center

    McInnis, Dion

    2001-01-01

    Because of limited resources and rising populations, more intentional relationships among university departments are needed to achieve common goals, especially in parent programming. Article focuses on novel partnering opportunities for student affairs and institutional advancement departments. (GCP)

  19. A framework for treating partner aggressive women.

    PubMed

    Dowd, Lynn; Leisring, Penny A

    2008-01-01

    Women are increasingly referred to intervention programs to address their use of physical violence against intimate partners. This article reviews the scant treatment outcome and attrition literature for partner aggressive women and describes important characteristics of partner aggressive women that must be taken into consideration in designing treatment. Recommended treatment modules are described in detail and include skill-building to enhance safety planning, conflict management, emotional regulation, communication and negotiation, and stress management. Additional modules should be included for some women based on individualized needs. These may include parenting skills and education and referral for treatment of conditions that undermine emotional stability, such as posttraumatic stress symptoms, substance abuse, and mood disorders. Treatment structure is outlined and pragmatic issues regarding the implementation of treatment are discussed. Interventions for partner aggressive woman must be designed to address women's victimization experiences as well as their perpetration. PMID:18624093

  20. Cheating Partners, Conditional Probability and Contingency Tables

    ERIC Educational Resources Information Center

    Watson, Jane M.

    2011-01-01

    Developing statistical literacy for older school students includes recognizing and interpreting conditional statements in the media. Data on couples' success in predicting whether their partners have cheated provides a motivating context for teachers to lead their students through this process.

  1. Commercial Crew Program CCiCap Partners

    NASA Video Gallery

    NASA's Commercial Crew Program and its newest Commercial Crew Integrated Capability (CCiCap) partners are embracing the American spirit as they advance their integrated rocket and spacecraft design...

  2. Developing Community Partner Training: Regulations and Relationships

    PubMed Central

    Solomon, Stephanie; Piechowski, Patricia J.

    2012-01-01

    While funders increasingly support research that partners with communities, community partners still must submit to a regulatory oversight structure that does not reflect their unique research ethics challenges and needs. In recognition of the importance of collaborative research endeavors, the authors engaged in a process of reconnaissance and negotiations with local community partners and research ethics boards (REBs) at the University of Michigan to begin to address the mismatch between regulatory demands and community-based research realities. This preliminary process yielded both changes in the REB oversight structure and training required of community partnered research. While the ultimate impact of these changes remains to be seen, the process itself yielded insights and materials of use to both our local REBs, and hopefully those at other institutions as well. This article will present those insights and provide links to those materials. PMID:21680974

  3. Intimate Partner Violence among West African Immigrants

    PubMed Central

    AKINSULURE-SMITH, ADEYINKA M.; CHU, TRACY; KEATLEY, EVA; RASMUSSEN, ANDREW

    2013-01-01

    Although the number of African immigrants arriving to the United States has increased significantly, there has been little investigation regarding their experiences of intimate partner violence or coping strategies. This study used focus groups and individual interviews to explore intimate partner violence among 32 heterosexual West African immigrants. Results suggest that although cultural expectations influence their coping strategies, West African–born men and women face different realities, with women reporting multiple instances of abuse and a sense of frustration with the existing options for assistance. Although participants discussed multilevel support structures within the immediate West African community to address intimate partner violence, all of these options maintained a gender hierarchy, leaving women dissatisfied. Challenges and barriers to partner violence resolution and coping strategies are identified. Results are examined in terms of their implications for addressing the needs of this underserved population. Implications for future research and services are discussed and highlighted. PMID:23730146

  4. For Better Skin Cancer Checks, Partner Up

    MedlinePlus

    ... 159632.html For Better Skin Cancer Checks, Partner Up Melanoma survivors benefited when they and a loved ... the researchers explained. During two years of follow-up, 66 of the patients did go on to ...

  5. 76 FR 66012 - Partner's Distributive Share

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-25

    ...)(iii)(e) The de minimis partner rule in Sec. 1.704-1(b)(2)(iii)(e) (TD 9398, 73 FR 28699-01) was... Internal Revenue Service 26 CFR Part 1 RIN 1545-BJ37 Partner's Distributive Share AGENCY: Internal Revenue... through Friday between the hours of 8 a.m. and 4 p.m. to CC:PA:LPD:PR (REG- 109564-10), Courier's...

  6. Partner Choice in Raven (Corvus corax) Cooperation

    PubMed Central

    Asakawa-Haas, Kenji; Schiestl, Martina; Bugnyar, Thomas; Massen, Jorg J. M.

    2016-01-01

    Although social animals frequently make decisions about when or with whom to cooperate, little is known about the underlying mechanisms of partner choice. Most previous studies compared different dyads’ performances, though did not allow an actual choice among partners. We tested eleven ravens, Corvus corax, in triads, giving them first the choice to cooperate with either a highly familiar or a rather unfamiliar partner and, second, with either a friend or a non-friend using a cooperative string-pulling task. In either test, the ravens had a second choice and could cooperate with the other partner, given that this one had not pulled the string in the meantime. We show that during the experiments, these partner ravens indeed learn to wait and inhibit pulling, respectively. Moreover, the results of these two experiments show that ravens’ preferences for a specific cooperation partner are not based on familiarity. In contrast, the ravens did show a preference based on relationship quality, as they did choose to cooperate significantly more with friends than with non-friends and they were also more proficient when cooperating with a friend. In order to further identify the proximate mechanism of this preference, we designed an open-choice experiment for the whole group where all birds were free to cooperate on two separate apparatuses. This set-up allowed us to distinguish between preferences for close proximity and preferences to cooperate. The results revealed that friends preferred staying close to each other, but did not necessarily cooperate with one another, suggesting that tolerance of proximity and not relationship quality as a whole may be the driving force behind partner choice in raven cooperation. Consequently, we stress the importance of experiments that allow such titrations and, suggest that these results have important implications for the interpretations of cooperation studies that did not include open partner choice. PMID:27286247

  7. Perceptions of the physical attractiveness of the self, current romantic partners, and former partners.

    PubMed

    Swami, Viren; Allum, Lucy

    2012-02-01

    This study examined ratings of physical attractiveness of the self and former and current partners. A total of 304 participants completed measures of attractiveness, relationship satisfaction, love dimensions, self-esteem and sociosexual orientation. Consistent with previous work, results showed that participants rated their current partners as more attractive than themselves and their former partners. However, results also showed that former partners were rated as more attractive than the self on a number of bodily characteristics. Finally, results showed that ratings of former partner physical attractiveness were associated with passion for the former partner, self-esteem, sociosexual orientation, and attributions of relationship termination. These results are discussed in relation to the available literature on positive illusions in intimate relationships. PMID:21995611

  8. Partner choice creates fairness in humans.

    PubMed

    Debove, Stéphane; André, Jean-Baptiste; Baumard, Nicolas

    2015-06-01

    Many studies demonstrate that partner choice has played an important role in the evolution of human cooperation, but little work has tested its impact on the evolution of human fairness. In experiments involving divisions of money, people become either over-generous or over-selfish when they are in competition to be chosen as cooperative partners. Hence, it is difficult to see how partner choice could result in the evolution of fair, equal divisions. Here, we show that this puzzle can be solved if we consider the outside options on which partner choice operates. We conduct a behavioural experiment, run agent-based simulations and analyse a game-theoretic model to understand how outside options affect partner choice and fairness. All support the conclusion that partner choice leads to fairness only when individuals have equal outside options. We discuss how this condition has been met in our evolutionary history, and the implications of these findings for our understanding of other aspects of fairness less specific than preferences for equal divisions of resources. PMID:25972467

  9. Partner Caregiving in Older Cohabiting Couples

    PubMed Central

    2011-01-01

    Objectives. Despite the rapidly increasing prevalence of cohabitation among older adults, the caregiving literature has exclusively focused on formally married individuals. Extending prior work on intra-couple care, this study contrasts frail cohabitors’ patterns of care receipt from a partner to that of frail spouses. Methods. Using nationally representative panel data from the Health and Retirement Study (2000, 2002, 2004, and 2006), we estimate random effects cross-sectional times series models predicting frail cohabitors’ likelihood of receiving partner care compared with their married counterparts’. Conditional on the receipt of intra-couple care, we also examine differences in marital and nonmarital partners’ caregiving hours and caregiving involvement relative to other helpers. Results. Net of sociodemographic, disability, and comorbidity factors, we find that cohabitors are less likely to receive partner care than married individuals. However, caregiving nonmarital partners provide as many hours of care as spouses while providing a substantially larger share of disabled respondents’ care than marital partners. Discussion. Cohabitation and marriage have distinct implications for older adults’ patterns of partner care receipt. This study adds weight to a growing body of research emphasizing the importance of accounting for older adults’ nontraditional union forms and of examining the ramifications of cohabitation for older adults’ well-being. PMID:21482588

  10. Partner choice creates fairness in humans

    PubMed Central

    Debove, Stéphane; André, Jean-Baptiste; Baumard, Nicolas

    2015-01-01

    Many studies demonstrate that partner choice has played an important role in the evolution of human cooperation, but little work has tested its impact on the evolution of human fairness. In experiments involving divisions of money, people become either over-generous or over-selfish when they are in competition to be chosen as cooperative partners. Hence, it is difficult to see how partner choice could result in the evolution of fair, equal divisions. Here, we show that this puzzle can be solved if we consider the outside options on which partner choice operates. We conduct a behavioural experiment, run agent-based simulations and analyse a game-theoretic model to understand how outside options affect partner choice and fairness. All support the conclusion that partner choice leads to fairness only when individuals have equal outside options. We discuss how this condition has been met in our evolutionary history, and the implications of these findings for our understanding of other aspects of fairness less specific than preferences for equal divisions of resources. PMID:25972467

  11. A Community-Academic Partnered Grant Writing Series to Build Infrastructure for Partnered Research.

    PubMed

    King, Keyonna M; Pardo, Yvette-Janine; Norris, Keith C; Diaz-Romero, Maria; Morris, D'Ann; Vassar, Stefanie D; Brown, Arleen F

    2015-10-01

    Grant writing is an essential skill necessary to secure financial support for community programs and research projects. Increasingly, funding opportunities for translational biomedical research require studies to engage community partners, patients, or other stakeholders in the research process to address their concerns. However, there is little evidence on strategies to prepare teams of academic and community partners to collaborate on grants. This paper presents the description and formative evaluation of a two-part community-academic partnered grant writing series designed to help community organizations and academic institutions build infrastructure for collaborative research projects using a partnered approach. The first phase of the series was a half-day workshop on grant readiness, which was open to all interested community partners. The second phase, open only to community-academic teams that met eligibility criteria, was a 12-week session that covered partnered grant writing for foundation grants and National Institutes of Health grants. Participants in both phases reported an increase in knowledge and self-efficacy for writing partnered proposals. At 1-year follow-up, participants in Phase 2 had secured approximately $1.87 million in funding. This community-academic partnered grant writing series helped participants obtain proposal development skills and helped community-academic teams successfully compete for funding. PMID:26365589

  12. 26 CFR 301.6224(c)-1 - Tax matters partner may bind nonnotice partners.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... of fraud, malfeasance, or misrepresentation of fact, if the tax matters partner enters into a... contained in 26 CFR part 1, revised April 1, 2001. ... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Tax matters partner may bind nonnotice...

  13. 26 CFR 301.6224(c)-1 - Tax matters partner may bind nonnotice partners.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... of fraud, malfeasance, or misrepresentation of fact, if the tax matters partner enters into a... contained in 26 CFR part 1, revised April 1, 2001. ... 26 Internal Revenue 18 2011-04-01 2011-04-01 false Tax matters partner may bind nonnotice...

  14. 26 CFR 301.6224(c)-1 - Tax matters partner may bind nonnotice partners.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... of fraud, malfeasance, or misrepresentation of fact, if the tax matters partner enters into a... contained in 26 CFR part 1, revised April 1, 2001. ... 26 Internal Revenue 18 2012-04-01 2012-04-01 false Tax matters partner may bind nonnotice...

  15. 26 CFR 301.6224(c)-1 - Tax matters partner may bind nonnotice partners.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... of fraud, malfeasance, or misrepresentation of fact, if the tax matters partner enters into a... contained in 26 CFR part 1, revised April 1, 2001. ... 26 Internal Revenue 18 2014-04-01 2014-04-01 false Tax matters partner may bind nonnotice...

  16. 26 CFR 301.6224(c)-1 - Tax matters partner may bind nonnotice partners.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... of fraud, malfeasance, or misrepresentation of fact, if the tax matters partner enters into a... contained in 26 CFR part 1, revised April 1, 2001. ... 26 Internal Revenue 18 2013-04-01 2013-04-01 false Tax matters partner may bind nonnotice...

  17. Examining intimate partner aggression assessment among returning veterans and their partners.

    PubMed

    LaMotte, Adam D; Taft, Casey T; Weatherill, Robin P; Scott, Jillian Panuzio; Eckhardt, Christopher I

    2014-03-01

    There is a growing research base focusing on intimate partner aggression (IPA) in combat veterans, although little work has focused on IPA assessment. In the current study, the authors investigated IPA assessment among 65 male Operation Iraqi Freedom (OIF) and Operation Enduring Freedom (OEF) combat veterans and their female partners. Specifically, we compared overall levels of veteran- and partner-perpetrated IPA, conducted concordance analyses to examine the degree of interpartner agreement on IPA occurrence and frequency, and investigated both veterans' and partners' relationship satisfaction and posttraumatic stress disorder (PTSD) symptoms as correlates of concordance. Results indicated that female partners perpetrated higher levels of physical IPA than did the male veterans, according to both veteran and combined reports. Concordance analyses revealed low to moderate levels of agreement between veterans and their partners on the perpetration of physical and psychological IPA, with particularly low agreement on the veterans' physical IPA. Female partners' relationship satisfaction was associated with reporting less of the veterans' and their own IPA relative to the veterans' reports, and their PTSD symptoms were associated with reporting more of the veterans' and their own IPA. In contrast, the veterans' PTSD symptoms were associated with reporting less of their own IPA relative to their partners' reports. The findings emphasize the need for those researching and treating IPA among military couples to assess IPA perpetrated by both members of the relationship and to consider possible factors that might impact the accuracy of IPA reporting. PMID:24079959

  18. AIDS, partner notification and gender issues.

    PubMed

    Hildesheimer, Galya M

    2002-01-01

    The interplay between public health, human rights, legal obligations and physicians' ethical concerns was revealed dramatically in Israel in recent cases involving reporting of the HIV positive status of patients. This paper reviews and critically analyses the decision-making process of Israeli Ethics Committees regarding HIV partner notification. One aim of this analysis is to suggest principles that may guide the decision in such cases. It is argued that the resolution concerning disclosure to partners be based on the Principle of Proportionality, taking into account the type of relationship between partner and patient, their cultural background and gender issues. The paper demonstrates the advantages of addressing such issues by professional multidisciplinary Ethics Committees, whose decisions can bring to bear the scope of relevant considerations. PMID:12017441

  19. [Typology of incarcerated intimate partner aggressors].

    PubMed

    Loinaz, Ismael; Echeburúa, Enrique; Torrubia, Rafael

    2010-02-01

    Typology of incarcerated intimate partner aggressors. People who engage in intimate partner violence do not constitute a homogeneous group. Many studies in the Anglo-Saxon countries back the possibility of differentiating several subtypes of aggressors, but there are differences among them. One of the main applications of these typologies is the adaptation of the treatments to the subjects' characteristics. The aim of the present pilot study was to empirically establish a typology of batterers in Spain. The sample of 50 convicted violent intimate partner offenders was obtained from the Brians-2 penitentiary (Barcelona). Self-esteem, anger, cognitive distortions, and personality disorders were evaluated, as well as the frequency and type of violence. The results suggest the existence of two subtypes, distinguishable on the basis of the predictive dimensions, and so, partially confirm the typological proposals. PMID:20100435

  20. Parkinson patients as partners in care.

    PubMed

    Hirsch, Mark A; Sanjak, Mohammed; Englert, Danielle; Iyer, Sanjay; Quinlan, Margaret M

    2014-01-01

    Increasing physical activity, as part of an active lifestyle, is an important health goal for individuals with Parkinson's disease (PD). Exercise can positively impact health related quality of life. Given this, how can we promote physically active lifestyles among PD patients (most of whom are sedentary)? Here we suggest that health care professionals could significantly expand their impact by collaborating with PD patients and their spouses (or caregivers) as partners-in-care. We outline reasons why partners-in-care approaches are important in PD, including the need to increase social capital, which deals with issues of trust and the value of social networks in linking members of a community. We then present results of a qualitative study involving partners-in-care exercise beliefs among 19 PD patients and spouses, and conclude with our perspective on future benefits of this approach. PMID:24262175

  1. Witness of Intimate Partner Violence in Childhood and Perpetration of Intimate Partner Violence in Adulthood

    PubMed Central

    Roberts, Andrea L.; Gilman, Stephen E.; Fitzmaurice, Garrett; Decker, Michele R.; Koenen, Karestan C.

    2011-01-01

    Background At least half a million women are victims of intimate partner violence in the United States annually, resulting in substantial harm. However, the etiology of violence to intimate partners is not well understood. Witnessing such violence in childhood has been proposed as a principal cause of adulthood perpetration, yet it remains unknown whether the association between witnessing intimate partner violence and adulthood perpetration is causal. Method We conducted a propensity-score analysis of intimate partner violence perpetration to determine whether childhood witnessing is associated with perpetration in adulthood, independent of a wide range of potential confounding variables, and therefore might be a causal factor. We used data from 14,564 U.S. men ages 20 and older from the 2004–2005 wave of the National Epidemiologic Survey on Alcohol and Related Conditions. Results Nearly 4% of men reported violent behavior toward an intimate partner in the past year. In unadjusted models, we found a strong association between childhood witnessing of intimate partner violence and adulthood perpetration (for witnessing any intimate partner violence, risk ratio [RR] = 2.6 [95% confidence interval = 2.1–3.2]; for witnessing frequent or serious violence, 3.0 [2.3–3.9]). In propensity-score models, the association was substantially attenuated (for witnessing any intimate partner violence, adjusted RR = 1.6 [1.2–2.0]; for witnessing frequent or serious violence, 1.6 [1.2–2.3]). Conclusions Men who witness intimate partner violence in childhood are more likely to commit such acts in adulthood, compared with men who are otherwise similar with respect to a large range of potential confounders. Etiological models of intimate partner violence perpetration should consider a constellation of childhood factors. PMID:20811285

  2. Sexuality and the Commission of Physical Violence to Partners and Non-Partners by Men and Women

    ERIC Educational Resources Information Center

    Cogan, Rosemary; Fennell, Tiffanie

    2007-01-01

    In 2 studies of physical violence and sexuality among college students, more than 75% of men and more than 60% of women reported committing physical violence in the past year, including more women to partners and more men to non-partners. More than 90% of men who committed violence to partners were also violent to non-partners. In Study 1, among…

  3. When a partner dies: lesbian widows.

    PubMed

    Bent, Katherine N; Magilvy, J Kathy

    2006-06-01

    Death of a life partner and the subsequent bereavement are profound experiences for an individual. By far, the majority of bereavement research reported is focused on heterosexual couples, primarily married and often in the later years of life. The purpose of this study was to describe the bereavement experiences of lesbians whose life partners have died. The study used a descriptive, qualitative design informed by feminist scholarship and phenomenology to access the depth of personal experiences, as well as internally interpreted meanings of those experiences, among lesbian widows. PMID:16613798

  4. Partners in policymaking: the first five years.

    PubMed

    Zirpoli, T J; Wieck, C; Hancox, D; Skarnulis, E R

    1994-12-01

    Many individuals with disabilities and their families are becoming empowered by learning effective self-advocacy strategies. In this article one enpowerment and self-advocacy training program, Partners in Policymaking, for parents of young children and adults with disabilities was described. Initially developed in Minnesota, the Partners program has completed its fifth year, has 163 graduates, and is being replicated in several other states. Follow-up data, qualitative and quantitative, were collected from program graduates. Results indicated both satisfaction with the program and the presence of many active citizen-advocates in the community. PMID:7854135

  5. Community-Partnered Research Conference Model: The Experience of Community Partners in Care Study

    PubMed Central

    Khodyakov, Dmitry; Pulido, Esmeralda; Ramos, Ana; Dixon, Elizabeth

    2013-01-01

    The Problem Conducting community-partnered research conferences is a powerful yet underutilized approach to translating research into practice and improving result dissemination and intervention sustainability strategies. Nonetheless, detailed descriptions of conference features and ways to use them in empirical research are rare. Purpose of Article We describe how community-partnered conferences may be integrated into research projects by using an example of Community Partners in Care, a large cluster-randomized controlled trial that uses Community Partnered Participatory Research principles. Key Points Our conceptual model illustrates the role community-partnered research conferences may play in three study phases and describes how different conference features may increase community engagement, build two-way capacity, and ensure equal project ownership. Conclusion(s) As the number of community-partnered studies grows, so too does the need for practical tools to support this work. Community-partnered research conferences may be effectively employed in translational research to increase two-way capacity-building and promote long-term intervention success. PMID:24859106

  6. Associations of unprotected anal intercourse with Grindr-met partners among Grindr-using young men who have sex with men in Los Angeles.

    PubMed

    Winetrobe, Hailey; Rice, Eric; Bauermeister, Jose; Petering, Robin; Holloway, Ian W

    2014-01-01

    Grindr, a geosocial smartphone application, is a networking medium for men who have sex with men. Although three quarters of young men who have sex with men (YMSM) Grindr users report having sex with a Grindr-met partner, the correlates of risky sexual behavior with Grindr-met partners are unknown. A randomly selected sample of 18- to 24-year-old, Grindr-using YMSM completed an anonymous online questionnaire assessing patterns of Grindr use and sexual behavior with their last Grindr-met partners. Of the 146 YMSM who reported having sex with Grindr-met partners, 20% had unprotected anal intercourse (UAI) at last sex with their Grindr-met partner. In the multivariable model, YMSM who used Grindr for at least one year showed naked chest/abs in their profile photo, and reported more past month Grindr-met partners were more likely to report UAI. These findings suggest that familiarity with the app was associated with YMSM's UAI with Grindr-met partners. Moreover, sexualized profile photos (i.e., naked chest/abs) may be associated with sexual risk-taking behaviors. HIV prevention interventions delivered or linked through such apps should target individuals who are longer/frequent users and who present sexualized profiles. PMID:24754563

  7. Subtyping Male Perpetrators of Intimate Partner Violence

    ERIC Educational Resources Information Center

    Fowler, Katherine A.; Westen, Drew

    2011-01-01

    Domestic violence is a serious problem with far-reaching consequences. This study applies a new methodology to derive subtypes of male perpetrators of intimate partner violence. As part of a larger National Institute of Mental Health (NIMH)-funded study, a national sample of randomly selected psychologists and psychiatrists describe 188 adult male…

  8. Risk Recognition and Intimate Partner Violence

    ERIC Educational Resources Information Center

    Witte, Tricia H.; Kendra, Rachel

    2010-01-01

    The objective of this study was to determine whether female victims of physical forms of intimate partner violence (IPV) displayed deficits in risk recognition, or the ability to detect danger, in physically violent dating encounters. A total of 182 women watched a video depicting a psychologically and physically aggressive encounter between…

  9. Librarians as Community Partners: An Outreach Handbook

    ERIC Educational Resources Information Center

    Smallwood, Carol, Ed.

    2010-01-01

    Including 66 focused snapshots of outreach in action, this resource reflects the creative solutions of librarians searching for new and innovative ways to build programs that meet customer needs while expanding the library's scope into the community. This contributed volume includes: (1) A huge array of program options for partnering with other…

  10. Sleep Loss and Partner Violence Victimization

    ERIC Educational Resources Information Center

    Walker, Robert; Shannon, Lisa; Logan, T. K.

    2011-01-01

    Intimate partner violence victimization has been associated with serious health problems among women, including many disorders that involve sleep disturbances. However, there has been only limited examination of sleep duration among women with victimization experiences. A total of 756 women with a domestic violence order (DVO) against a male…

  11. Sound Partners. What Works Clearinghouse Intervention Report

    ERIC Educational Resources Information Center

    What Works Clearinghouse, 2010

    2010-01-01

    "Sound Partners" (Vadasy et al., 2004) is a phonics-based tutoring program that provides supplemental reading instruction to elementary school students grades K-3 with below average reading skills. The program is designed specifically for use by tutors with minimal training and experience. Instruction emphasizes letter-sound correspondences,…

  12. Expanding NASA Science Cooperation with New Partners

    NASA Astrophysics Data System (ADS)

    Allen, Marc; Bress, Kent

    Expanding NASA Science Cooperation with New Partners When NASA was created in 1958, it was given a goal of "cooperation by the United States with other nations and groups of nations in work done pursuant to this Act and in the peaceful application of the results." As science has become increasingly globalized during the past 50 years, NASA and its many partners in space and Earth science research have benefited enormously from pooling ideas, skills, and resources for joint undertakings. The discoveries made have powerfully advanced public awareness of science and its importance all over the world. Today, the U.S. Administra-tion is encouraging NASA to expand its cooperation with new and emerging partners. NASA space and Earth science cooperation is founded on scientist-to-scientist research collaboration. Space missions are very costly and technically challenging, but there are many other important areas for international cooperation. Areas ripe for expansion with new partners include space data sharing, scientist-to-scientist collaborative research, international research program plan-ning and coordination, Earth applications for societal benefit, ground-based measurements for Earth system science, and education and public outreach. This presentation lays out NASA's general principles for international science cooperation, briefly describes each of these opportu-nity areas, and suggests avenues for initiating new cooperative relationships.

  13. Gender Symmetry, Sexism, and Intimate Partner Violence

    ERIC Educational Resources Information Center

    Allen, Christopher T.; Swan, Suzanne C.; Raghavan, Chitra

    2009-01-01

    This study of a predominantly Hispanic sample of 92 male and 140 female college students examines both gender symmetry in intimate partner violence (IPV) and inconsistent relationships found in previous studies between sexist attitudes and IPV. Results indicate that although comparable numbers of men and women perpetrate and are victimized in…

  14. The Forgotten Partner: The Superintendent's Husband.

    ERIC Educational Resources Information Center

    Staples, Judith; Neal, Christine

    2000-01-01

    Female superintendents prize spouses who are emotionally secure and supportive and assist with household chores. Partners should communicate priorities, vacation together periodically, keep healthy, stay flexible, avoid guilt, establish family rituals, stay in frequent contact, respect each others' roles, and not strive for perfect balance. (MLH)

  15. Sustained Engagement with a Single Community Partner

    ERIC Educational Resources Information Center

    Lear, Darcy W.; Sanchez, Alejandro

    2013-01-01

    As scholarly work has recently turned its attention to the role of the community partner in Community Service-Learning (CSL) relationships, empirical frameworks for describing and executing community partnerships have emerged. This article applies those frameworks to one such partnership, which is presented from the perspective of both the…

  16. Intimate Partner Violence within Law Enforcement Families

    ERIC Educational Resources Information Center

    Anderson, Anita S.; Lo, Celia C.

    2011-01-01

    Using data from the Baltimore Police Stress and Domestic Violence study, the authors examined how exposure to stressful events on the job affects law enforcement employees' physical aggression toward domestic partners, evaluating the role of negative emotions and authoritarian spillover in mediating the impact of such task-related stress. The…

  17. Women's Response to Intimate Partner Violence

    ERIC Educational Resources Information Center

    Ruiz-Perez, Isabel; Mata-Pariente, Nelva; Plazaola-Castano, Juncal

    2006-01-01

    The responses of women to a situation of abuse by their partner has hardly been addressed in the literature. Using a self-administered, anonymous questionnaire, 400 women attending three practices in a primary health care center in Granada (Spain) were studied. The women's response to abuse was used as a dependent variable. Sociodemographics,…

  18. Physical Health Effects of Intimate Partner Abuse

    ERIC Educational Resources Information Center

    Sillito, Carrie LeFevre

    2012-01-01

    Although intimate partner violence has been recognized as both a social problem and health issue, the extent to which it is a health issue for both males and females in the general population is largely unknown. This longitudinal research uses data from the National Survey of Family and Households (1987-2003). Random effects logistic regression…

  19. Strategy Guideline: Partnering for High Performance Homes

    SciTech Connect

    Prahl, D.

    2013-01-01

    High performance houses require a high degree of coordination and have significant interdependencies between various systems in order to perform properly, meet customer expectations, and minimize risks for the builder. Responsibility for the key performance attributes is shared across the project team and can be well coordinated through advanced partnering strategies. For high performance homes, traditional partnerships need to be matured to the next level and be expanded to all members of the project team including trades, suppliers, manufacturers, HERS raters, designers, architects, and building officials as appropriate. In an environment where the builder is the only source of communication between trades and consultants and where relationships are, in general, adversarial as opposed to cooperative, the chances of any one building system to fail are greater. Furthermore, it is much harder for the builder to identify and capitalize on synergistic opportunities. Partnering can help bridge the cross-functional aspects of the systems approach and achieve performance-based criteria. Critical success factors for partnering include support from top management, mutual trust, effective and open communication, effective coordination around common goals, team building, appropriate use of an outside facilitator, a partnering charter progress toward common goals, an effective problem-solving process, long-term commitment, continuous improvement, and a positive experience for all involved.

  20. Parents-as-Partners-as-Learners Guide.

    ERIC Educational Resources Information Center

    Fear, Marion

    This guide provides information on the Parents-as-Partners-as-Learners project that is designed to encourage a love of reading in children and to increase communication between the home and school. Section A is an overview of the four phases of the project that are initiated by an adult literacy animator (facilitator) in a primary school: Phase I,…

  1. Head Injury in Partner-Abusive Men.

    ERIC Educational Resources Information Center

    Rosenbaum, Alan; And Others

    1994-01-01

    Fifty-three partner-abusive men, 45 maritally satisfied, and 32 maritally discordant, nonviolent men were evaluated for past history of head injury. Logistic regressions confirmed head injury was significant predictor of being a batterer. Implications of findings for both marital aggression and posthead injury rehabilitation are discussed. (Author)

  2. Programs of 1993 Winning Teams: Pioneering Partners.

    ERIC Educational Resources Information Center

    1993

    Pioneering Partners for Educational Technology was created to enhance learning in K-12 classrooms by accelerating the use of educational technology. This document outlines the projects of the 1993 winning teams. The Illinois programs are: "A Travel Log Via Computer"; "Weatherization Audit Training for Teachers and Students"; and "Technology for…

  3. Be a Partner in Clinical Research

    MedlinePlus

    ... part of the U.S. Department of Health and Human Services Latest Issue This Issue Features Be a Partner in Clinical Research Better Check Your Bowels Health Capsules Are You at Risk for Alcohol-Medication Interactions? Measles: Preventable with Vaccines Featured Website: National Center ...

  4. Programs of 1992 Winning Teams. Pioneering Partners.

    ERIC Educational Resources Information Center

    Council of Great Lakes Governors, Inc., Madison, WI.

    Pioneering Partners for Educational Technology was created to enhance learning in kindergarten through grade 12 by accelerating the use of educational technology. The program spotlights 24 project teams from Great Lakes states that are already using technology in creative ways in the following states: (1) Illinois; (2) Indiana; (3) Michigan; (4)…

  5. Individual differences in the propensity for partner sexual coercion.

    PubMed

    Camilleri, Joseph A; Quinsey, Vernon L

    2009-03-01

    Lalumière, Harris, Quinsey, and Rice (2005) proposed a three-path model (psychopathy, young male syndrome, and competitive disadvantage) of the development of sexually coercive behavior, but none of these individual difference characteristics have been tested among partner rapists. Using a community sample in Study 1, the authors find that psychopathy is the only significant predictor of self-reported propensity for partner sexual coercion. This model is tested in Study 2 by comparing convicted partner rapists, nonsexual partner assaulters, and heterosexual child molesters. One third of partner rapists are psychopaths, and their psychopathy scores are no different from those found in correctional samples. Partner rapists have an average IQ, providing further evidence that competitive disadvantage is less characteristic of partner rapists. There is some indication that partner rapists desist with age. The authors discuss these findings in light of recent findings that implicate cuckoldry risk in partner sexual assault. PMID:19218481

  6. Toxicogenomic Dissection of the Perfluorooctanoic Acid Transcript Profile in Mouse Liver: Evidence for the Involvement of Nuclear Receptors PPARα and CAR

    EPA Science Inventory

    A number of perfluorinated alkyl acids including perfluorooctanoic acid (PFOA) elicit effects similar to peroxisome proliferator chemicals (PPC) in mouse and rat liver. There is strong evidence that PPC cause many of their effects linked to liver cancer through the nuclear recep...

  7. Gender, Psychopathy Factors and Intimate Partner Violence

    PubMed Central

    Mager, Kenna L.; Bresin, Konrad; Verona, Edelyn

    2014-01-01

    The present study sheds light on relationships between distinct psychopathic traits and perpetration of IPV in women versus men. Men and women with recent drug and/or violence histories (N = 250) were assessed for psychopathic traits using the Psychopathy Checklist: Screening Version and for their and their partner's use of IPV with the Revised Conflict Tactics Scale. The first goal was to examine the moderating role of gender in psychopathy factor relationships to IPV. Although both the interpersonal-affective traits (Factor1) and the impulsive-antisocial traits (Factor 2) of psychopathy were related to higher frequency of IPV perpetration, the relationship between Factor 1 and IPV was stronger in men. Our second goal examined the moderating role of psychopathy traits in the relationship between partner's perpetration of IPV and participant perpetration (mutual violence) in the two genders. Relationships between partner- and self-IPV were similar at both low and high levels of Factor 1 in men, although the partner- and self-IPV relationship was significantly stronger among women at low relative to high levels of Factor 1. The relationship between partner- and self-IPV was stronger at high levels of Factor 2 in men, whereas Factor 2 did not moderate mutual violence in women. These results indicate that relationships between psychopathy factors and IPV differ by gender, with psychopathy generally exacerbating IPV perpetration in men and Factor 1 traits playing a unique role in mutual violence in women. These findings add to the literature on female psychopathy and have important implications for future research on gender and IPV. PMID:25020252

  8. Exploring the intersection of partner stalking and sexual abuse.

    PubMed

    Logan, T K; Cole, Jennifer

    2011-07-01

    This study examined a range of sexually abusive acts women with protective orders against violent partners experienced using three groups: (a) women who never experience stalking or rape by the violent partner; (b) women who experienced stalking but who had never been raped by the violent partner; and (c) women who were stalked and raped by the violent partner. Findings suggest that women in violent relationships experienced a wide range of sexually abusive experiences and that there is a significant association of partner stalking and partner sexual abuse beyond rape. Implications for practice and future research are discussed. PMID:21665857

  9. Identification of FAM96B as a novel prelamin A binding partner.

    PubMed

    Xiong, Xing-Dong; Wang, Junwen; Zheng, Huiling; Jing, Xia; Liu, Zhenjie; Zhou, Zhongjun; Liu, Xinguang

    2013-10-11

    Prelamin A accumulation causes nuclear abnormalities, impairs nuclear functions, and eventually promotes cellular senescence. However, the underlying mechanism of how prelamin A promotes cellular senescence is still poorly understood. Here we carried out a yeast two-hybrid screen using a human skeletal muscle cDNA library to search for prelamin A binding partners, and identified FAM96B as a prelamin A binding partner. The interaction of FAM96B with prelamin A was confirmed by GST pull-down and co-immunoprecipitation experiments. Furthermore, co-localization experiments by fluorescent confocal microscopy revealed that FAM96B colocalized with prelamin A in HEK-293 cells. Taken together, our data demonstrated the physical interaction between FAM96B and prelamin A, which may provide some clues to the mechanisms of prelamin A in premature aging. PMID:24041693

  10. BWR AXIAL PROFILE

    SciTech Connect

    J. Huffer

    2004-09-28

    The purpose of this calculation is to develop axial profiles for estimating the axial variation in burnup of a boiling water reactor (BWR) assembly spent nuclear fuel (SNF) given the average burnup of an assembly. A discharged fuel assembly typically exhibits higher burnup in the center and lower burnup at the ends of the assembly. Criticality safety analyses taking credit for SNF burnup must account for axially varying burnup relative to calculations based on uniformly distributed assembly average burnup due to the under-burned tips. Thus, accounting for axially varying burnup in criticality analyses is also referred to as accounting for the ''end effect'' reactivity. The magnitude of the reactivity change due to ''end effect'' is dependent on the initial assembly enrichment, the assembly average burnup, and the particular axial profile characterizing the burnup distribution. The set of bounding axial profiles should incorporate multiple BWR core designs and provide statistical confidence (95 percent confidence that 95 percent of the population is bound by the profile) that end nodes are conservatively represented. The profiles should also conserve the overall burnup of the fuel assembly. More background on BWR axial profiles is provided in Attachment I.

  11. 76 FR 50715 - Briefing on Partner Vetting System Pilot Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-16

    ...; ] DEPARTMENT OF STATE Agency for International Development Briefing on Partner Vetting System Pilot Program... briefing. SUMMARY: Notice is hereby given of a briefing on the Partner Vetting System (PVS) pilot...

  12. Sex Partner with No Zika Symptoms Transmits Virus: CDC

    MedlinePlus

    ... html Sex Partner With No Zika Symptoms Transmits Virus: CDC New report also highlights ties between Zika ... News) -- U.S. health officials report that the Zika virus can be spread sexually even when a partner ...

  13. National Intimate Partner and Sexual Violence Survey: 2010 Highlights

    MedlinePlus

    National Intimate Partner and Sexual Violence Survey CDC’s National Intimate Partner and Sexual Violence Survey (NISVS) is an ongoing, nationally-representative telephone survey that collects detailed information ...

  14. HEIGHT, PARTNERS AND OFFSPRING: EVIDENCE FROM TAIWAN.

    PubMed

    Tao, Hung-Lin; Yin, Ching-Chen

    2016-09-01

    Using Taiwanese data, this study finds that tall males are more successful in mate selection and reproduction, but the results are weakly significant. Height is not helpful for females' reproductive success. Specifically, tall males are more likely to have a partner at present or in the past, have at least one child, have more children, have a shorter period of celibacy and have a longer time duration of living with a partner in their lifetime. Using mediation analysis, the study shows that tall males' reproductive success is not due to their achievements in the labour market (earnings), but is simply due to their height per se. Finally, a college student data set is used to explore the relation between height and dating hours. Tall male students have more dating hours, but no relation is found between females' height and dating hours. PMID:26449270

  15. Efficient DSMC collision-partner selection schemes.

    SciTech Connect

    Gallis, Michail A.; Torczynski, John Robert

    2010-07-01

    The effect of collision-partner selection schemes on the accuracy and the efficiency of the Direct Simulation Monte Carlo (DSMC) method of Bird is investigated. Several schemes to reduce the total discretization error as a function of the mean collision separation and the mean collision time are examined. These include the historically first sub-cell scheme, the more recent nearest-neighbor scheme, and various near-neighbor schemes, which are evaluated for their effect on the thermal conductivity for Fourier flow. Their convergence characteristics as a function of spatial and temporal discretization and the number of simulators per cell are compared to the convergence characteristics of the sophisticated and standard DSMC algorithms. Improved performance is obtained if the population from which possible collision partners are selected is an appropriate fraction of the population of the cell.

  16. Efficient DSMC collision-partner selection schemes.

    SciTech Connect

    Gallis, Michail A.; Torczynski, John Robert

    2010-05-01

    The effect of collision-partner selection schemes on the accuracy and the efficiency of the Direct Simulation Monte Carlo (DSMC) method of Bird is investigated. Several schemes to reduce the total discretization error as a function of the mean collision separation and the mean collision time are examined. These include the historically first sub-cell scheme, the more recent nearest-neighbor scheme, and various near-neighbor schemes, which are evaluated for their effect on the thermal conductivity for Fourier flow. Their convergence characteristics as a function of spatial and temporal discretization and the number of simulators per cell are compared to the convergence characteristics of the sophisticated and standard DSMC algorithms. Improved performance is obtained if the population from which possible collision partners are selected is an appropriate fraction of the population of the cell.

  17. Intimate partner violence and children's memory.

    PubMed

    Gustafsson, Hanna C; Coffman, Jennifer L; Harris, Latonya S; Langley, Hillary A; Ornstein, Peter A; Cox, Martha J

    2013-12-01

    The current study was designed to examine the relation between intimate partner violence (IPV) and children's memory and drew from a socioeconomically and racially diverse sample of children living in and around a midsized southeastern city (n = 140). Mother-reported IPV when the children were 30 months old was a significant predictor of children's short-term, working, and deliberate memory at 60 months of age, even after controlling for the children's sex and race, the families' income-to-needs ratio, the children's expressive vocabulary, and maternal harsh-intrusive parenting behaviors. These findings add to the limited extant literature that finds linkages between IPV and children's cognitive functioning and suggest that living in households in which physical violence is perpetrated among intimate partners may have a negative effect on multiple domains of children's memory development. PMID:24188084

  18. Nurses Christian Fellowship International: Partners in Care.

    PubMed

    White, Barbara

    2013-01-01

    The Nurses Christian Fellowship International Quadrennial Conference was held November 5-10, 2012, in Santiago, Chile. The theme, "Partners in Care: Unity in diversity through Christ" brought together nurses from all over the world for Bible teaching, education, networking, and fellowship. Plenary and session abstracts are available as supplemental digital content through the HTML and PDF versions of this article at journalofchristiannursing.com. PMID:23607156

  19. Social norms for intimate partner violence.

    PubMed

    Witte, Tricia H; Mulla, Mazheruddin M

    2013-01-01

    This study investigated perceived descriptive norms (i.e., perceived prevalence) for intimate partner violence (IPV) among college students. Male and female college students were asked to estimate the prevalence of IPV for same-sex "typical students" on their campus. Perpetrators of IPV made higher estimates than nonperpetrators. Both perpetrators and nonperpetrators overestimated the prevalence of IPV when compared to actual prevalence rates. Findings lend support for using social-norms-based prevention programs on college campuses. PMID:24547674

  20. Patterns in PARTNERing across Public Health Collaboratives

    PubMed Central

    Bevc, Christine A.; Retrum, Jessica H.; Varda, Danielle M.

    2015-01-01

    Inter-organizational networks represent one of the most promising practice-based approaches in public health as a way to attain resources, share knowledge, and, in turn, improve population health outcomes. However, the interdependencies and effectiveness related to the structure, management, and costs of these networks represents a critical item to be addressed. The objective of this research is to identify and determine the extent to which potential partnering patterns influence the structure of collaborative networks. This study examines data collected by PARTNER, specifically public health networks (n = 162), to better understand the structured relationships and interactions among public health organizations and their partners, in relation to collaborative activities. Combined with descriptive analysis, we focus on the composition of public health collaboratives in a series of Exponential Random Graph (ERG) models to examine the partnerships between different organization types to identify the attribute-based effects promoting the formation of network ties within and across collaboratives. We found high variation within and between these collaboratives including composition, diversity, and interactions. The findings of this research suggest common and frequent types of partnerships, as well as opportunities to develop new collaborations. The result of this analysis offer additional evidence to inform and strengthen public health practice partnerships. PMID:26445053

  1. Do aphids actively search for ant partners?

    PubMed

    Fischer, Christophe Y; Vanderplanck, Maryse; Lognay, Georges C; Detrain, Claire; Verheggen, François J

    2015-04-01

    The aphid-ant mutualistic relationships are not necessarily obligate for neither partners but evidence is that such interactions provide them strong advantages in terms of global fitness. While it is largely assumed that ants actively search for their mutualistic partners namely using volatile cues; whether winged aphids (i.e., aphids' most mobile form) are able to select ant-frequented areas had not been investigated so far. Ant-frequented sites would indeed offer several advantages for these aphids including a lower predation pressure through ant presence and enhanced chances of establishing mutuaslistic interactions with neighbor ant colonies. In the field, aphid colonies are often observed in higher densities around ant nests, which is probably linked to a better survival ensured by ants' services. Nevertheless, this could also result from a preferential establishment of winged aphids in ant-frequented areas. We tested this last hypothesis through different ethological assays and show that the facultative myrmecophilous black bean aphid, Aphis fabae L., does not orientate its search for a host plant preferentially toward ant-frequented plants. However, our results suggest that ants reduce the number of winged aphids leaving the newly colonized plant. Thus, ants involved in facultative myrmecophilous interactions with aphids appear to contribute to structure aphid populations in the field by ensuring a better establishment and survival of newly established colonies rather than by inducing a deliberate plant selection by aphid partners based on the proximity of ant colonies. PMID:24659520

  2. Restricting mutualistic partners to enforce trade reliance.

    PubMed

    Wyatt, Gregory A K; Kiers, E Toby; Gardner, Andy; West, Stuart A

    2016-01-01

    Mutualisms are cooperative interactions between members of different species, often involving the trade of resources. Here, we suggest that otherwise-cooperative mutualists might be able to gain a benefit from actively restricting their partners' ability to obtain resources directly, hampering the ability of the restricted partner to survive and/or reproduce without the help of the restricting mutualist. We show that (i) restriction can be favoured when it makes the resources of the restricting individual more valuable to their partner, and thus allows them to receive more favourable terms of trade; (ii) restriction maintains cooperation in conditions where cooperative behaviour would otherwise collapse; and (iii) restriction can lead to either an increase or decrease in a restricted individual's fitness. We discuss the applicability of this scenario to mutualisms such as those between plants and mycorrhizal fungi. These results identify a novel conflict in mutualisms as well as several public goods dilemmas, but also demonstrate how conflict can help maintain cooperation. PMID:26813888

  3. Restricting mutualistic partners to enforce trade reliance

    PubMed Central

    Wyatt, Gregory A. K.; Kiers, E. Toby; Gardner, Andy; West, Stuart A.

    2016-01-01

    Mutualisms are cooperative interactions between members of different species, often involving the trade of resources. Here, we suggest that otherwise-cooperative mutualists might be able to gain a benefit from actively restricting their partners' ability to obtain resources directly, hampering the ability of the restricted partner to survive and/or reproduce without the help of the restricting mutualist. We show that (i) restriction can be favoured when it makes the resources of the restricting individual more valuable to their partner, and thus allows them to receive more favourable terms of trade; (ii) restriction maintains cooperation in conditions where cooperative behaviour would otherwise collapse; and (iii) restriction can lead to either an increase or decrease in a restricted individual's fitness. We discuss the applicability of this scenario to mutualisms such as those between plants and mycorrhizal fungi. These results identify a novel conflict in mutualisms as well as several public goods dilemmas, but also demonstrate how conflict can help maintain cooperation. PMID:26813888

  4. Patterns in PARTNERing across Public Health Collaboratives.

    PubMed

    Bevc, Christine A; Retrum, Jessica H; Varda, Danielle M

    2015-10-01

    Inter-organizational networks represent one of the most promising practice-based approaches in public health as a way to attain resources, share knowledge, and, in turn, improve population health outcomes. However, the interdependencies and effectiveness related to the structure, management, and costs of these networks represents a critical item to be addressed. The objective of this research is to identify and determine the extent to which potential partnering patterns influence the structure of collaborative networks. This study examines data collected by PARTNER, specifically public health networks (n = 162), to better understand the structured relationships and interactions among public health organizations and their partners, in relation to collaborative activities. Combined with descriptive analysis, we focus on the composition of public health collaboratives in a series of Exponential Random Graph (ERG) models to examine the partnerships between different organization types to identify the attribute-based effects promoting the formation of network ties within and across collaboratives. We found high variation within and between these collaboratives including composition, diversity, and interactions. The findings of this research suggest common and frequent types of partnerships, as well as opportunities to develop new collaborations. The result of this analysis offer additional evidence to inform and strengthen public health practice partnerships. PMID:26445053

  5. 45 CFR 162.915 - Trading partner agreements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Trading partner agreements. 162.915 Section 162... REQUIREMENTS ADMINISTRATIVE REQUIREMENTS General Provisions for Transactions § 162.915 Trading partner agreements. A covered entity must not enter into a trading partner agreement that would do any of...

  6. 12 CFR 1710.18 - Change of audit partner.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 7 2011-01-01 2011-01-01 false Change of audit partner. 1710.18 Section 1710... audit partner. An Enterprise may not accept audit services from an external auditing firm if the lead or coordinating audit partner who has primary responsibility for the external audit of the Enterprise, or...

  7. 12 CFR 1710.18 - Change of audit partner.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 9 2012-01-01 2012-01-01 false Change of audit partner. 1710.18 Section 1710... audit partner. An Enterprise may not accept audit services from an external auditing firm if the lead or coordinating audit partner who has primary responsibility for the external audit of the Enterprise, or...

  8. 12 CFR 1710.18 - Change of audit partner.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 9 2013-01-01 2013-01-01 false Change of audit partner. 1710.18 Section 1710... audit partner. An Enterprise may not accept audit services from an external auditing firm if the lead or coordinating audit partner who has primary responsibility for the external audit of the Enterprise, or...

  9. 12 CFR 1710.18 - Change of audit partner.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 10 2014-01-01 2014-01-01 false Change of audit partner. 1710.18 Section 1710... audit partner. An Enterprise may not accept audit services from an external auditing firm if the lead or coordinating audit partner who has primary responsibility for the external audit of the Enterprise, or...

  10. Factors Associated with Multiple-Partner Fertility among Fathers

    ERIC Educational Resources Information Center

    Manlove, Jennifer; Logan, Cassandra; Ikramullah, Erum; Holcombe, Emily

    2008-01-01

    This article uses a sample of 1,731 fathers aged 16 - 45 from the 2002 National Survey of Family Growth to identify factors associated with multiple-partner fertility. Almost one third of fathers who reported multiple-partner fertility did so across a series of nonmarital relationships, and nonmarital-only multiple-partner fertility has been…

  11. Partner Power: A Study of Two Distance Education Consortia

    ERIC Educational Resources Information Center

    Pidduck, Anne Banks; Carey, Tom

    2006-01-01

    This research reports findings from a study which explored the process and criteria of partner selection--how and why partners are chosen--for two distance education consortia. The researchers reviewed recent literature on partnerships and partner selection. Two Canada-wide distance education consortia were identified as large-scale case studies…

  12. Trends in Intimate Partner Violence: 1980-2008

    ERIC Educational Resources Information Center

    Powers, Rachael A.; Kaukinen, Catherine Elizabeth

    2012-01-01

    Research on trends in partner violence has primarily relied on official measures of victimization focusing primarily on women's risk for intimate partner homicide. The current study uses 28 years of data from the National Crime Victimization Survey (NCVS) to examine the trends of intimate partner violence against female victims and identify…

  13. Expression profiling of nuclear receptors in breast cancer identifies TLX as a mediator of growth and invasion in triple-negative breast cancer

    PubMed Central

    Remenyi, Judit; Banerji, Christopher R.S.; Lai, Chun-Fui; Periyasamy, Manikandan; Lombardo, Ylenia; Busonero, Claudia; Ottaviani, Silvia; Passey, Alun; Quinlan, Philip R.; Purdie, Colin A.; Jordan, Lee B.; Thompson, Alastair M.; Finn, Richard S.; Rueda, Oscar M.; Caldas, Carlos; Gil, Jesus; Coombes, R. Charles; Fuller-Pace, Frances V.; Teschendorff, Andrew E.; Buluwela, Laki; Ali, Simak

    2015-01-01

    The Nuclear Receptor (NR) superfamily of transcription factors comprises 48 members, several of which have been implicated in breast cancer. Most important is estrogen receptor-α (ERα), which is a key therapeutic target. ERα action is facilitated by co-operativity with other NR and there is evidence that ERα function may be recapitulated by other NRs in ERα-negative breast cancer. In order to examine the inter-relationships between nuclear receptors, and to obtain evidence for previously unsuspected roles for any NRs, we undertook quantitative RT-PCR and bioinformatics analysis to examine their expression in breast cancer. While most NRs were expressed, bioinformatic analyses differentiated tumours into distinct prognostic groups that were validated by analyzing public microarray data sets. Although ERα and progesterone receptor were dominant in distinguishing prognostic groups, other NR strengthened these groups. Clustering analysis identified several family members with potential importance in breast cancer. Specifically, RORγ is identified as being co-expressed with ERα, whilst several NRs are preferentially expressed in ERα-negative disease, with TLX expression being prognostic in this subtype. Functional studies demonstrated the importance of TLX in regulating growth and invasion in ERα-negative breast cancer cells. PMID:26280373

  14. The outreach-assisted model of partner notification with IDUs.

    PubMed Central

    Levy, J A; Fox, S E

    1998-01-01

    OBJECTIVE: This analysis describes the Outreach-Assisted Model of Partner Notification, an innovative strategy for encouraging seropositive injecting drug users (IDUs) to inform their partners of shared human immunodeficiency virus (HIV) exposure. The analysis focuses on two core components of the notification process: the identification of at-risk partners and preferences for self-tell vs. outreach assistance in informing partners of possible exposure to the virus. METHODS: Using community outreach techniques, 386 IDUs were recruited for HIV pretest counseling, testing, and partner notification over a 12-month period. Of these, 63 tested HIV seropositive, and all but three returned for their test results. The 60 who were informed of their serostatus were randomly assigned to either a minimal or an enhanced intervention condition. Participants assigned to the minimal (self-tell) group were strongly encouraged to inform their partners of possible exposure. Those assigned to the enhanced (outreach-assisted) group had the option of either informing one or more of their partner(s) themselves or choosing to have the project's outreach team do so. RESULTS: Together, the 60 index persons who received their results provided names or at least one piece of locating information for a total of 142 partners with whom they perceived having shared possible exposure to the virus within the past five years. By itself, drug use accounted for half of all partners named. Sexual behavior alone accounted for 25% of named partners. Eighty-two percent of the enhanced group preferred to have the outreach team tell at least one partner; the team was requested to notify 71% of the total number of partners whom this group named. CONCLUSIONS: Findings suggest that IDUs want to notify their partners of shared HIV exposure. Outreach assistance was the preferred mode in the majority of cases. Expanding traditional community-based HIV outreach activities to include delivering street

  15. Dyadic, Partner, and Social Network Influences on Intimate Partner Violence among Male-Male Couples

    PubMed Central

    Stephenson, Rob; Sato, Kimi N.; Finneran, Catherine

    2013-01-01

    Introduction: Despite a recent focus on intimate partner violence (IPV) among men who have sex with men (MSM), the male-male couple is largely absent from the IPV literature. Specifically, research on dyadic factors shaping IPV in male-male couples is lacking. Methods: We took a subsample of 403 gay/bisexual men with main partners from a 2011 survey of approximately 1,000 gay and bisexual men from Atlanta. Logistic regression models of recent (<12 month) experience and perpetration of physical and sexual IPV examined dyadic factors, including racial differences, age differences, and social network characteristics of couples as key covariates shaping the reporting of IPV. Results: Findings indicate that men were more likely to report perpetration of physical violence if they were a different race to their main partner, whereas main partner age was associated with decreased reporting of physical violence. Having social networks that contained more gay friends was associated with significant reductions in the reporting of IPV, whereas having social networks comprised of sex partners or closeted gay friends was associated with increased reporting of IPV victimization and perpetration. Conclusion: The results point to several unique factors shaping the reporting of IPV within male-male couples and highlight the need for intervention efforts and prevention programs that focus on male couples, a group largely absent from both research and prevention efforts. PMID:23930144

  16. Synchronising movements with the sounds of a virtual partner enhances partner likeability.

    PubMed

    Launay, Jacques; Dean, Roger T; Bailes, Freya

    2014-11-01

    Previous studies have demonstrated that synchronising movements with other people can influence affiliative behaviour towards them. While research has focused on synchronisation with visually observed movement, synchronisation with a partner who is heard may have similar effects. We replicate findings showing that synchronisation can influence ratings of likeability of a partner, but demonstrate that this is possible with virtual interaction, involving a video of a partner. Participants performed instructed synchrony in time to sounds instead of the observable actions of another person. Results show significantly higher ratings of likeability of a partner after moving at the same time as sounds attributed to that partner, compared with moving in between sounds. Objectively quantified synchrony also correlated with ratings of likeability. Belief that sounds were made by another person was manipulated in Experiment 2, and results demonstrate that when sounds are attributed to a computer, ratings of likeability are not affected by moving in or out of time. These findings demonstrate that interaction with sound can be experienced as social interaction in the absence of genuine interpersonal contact, which may help explain why people enjoy engaging with recorded music. PMID:24805849

  17. Theory-of-mind-related neural activity for one's romantic partner predicts partner well-being.

    PubMed

    Dodell-Feder, David; Felix, Steven; Yung, Matthew G; Hooker, Christine I

    2016-04-01

    Healthy social relationships are linked to myriad positive physical and mental health outcomes, raising the question of how to enhance relationship formation and quality. Behavioral data suggest that theory of mind (ToM) may be one such process. ToM is supported by a network of brain regions including the temporo-parietal junction (TPJ), medial prefrontal cortex and precuneus (PC). However, little research has investigated how the ToM network supports healthy social relationships. Here, we investigate whether recruitment of the ToM network when thinking about the mental states of one's romantic partner predicts the partner's well-being. We find that selectivity in left TPJ (LTPJ) and PC for beliefs vs physical attributes of one's partner is positively associated with partner well-being the day of and day after a meaningful encounter. Furthermore, LTPJ and PC selectivity moderated how the partner's perception of being understood during the encounter affected their later well-being. Finally, we find the association between ToM-related neural selectivity and well-being robust to other factors related to the relationship and the encounter. Together, these data suggest that selective engagement of the neural network supporting ToM may be a key ingredient for the development and maintenance of healthy romantic relationships. PMID:26609107

  18. Identifying unique and shared risk factors for physical intimate partner violence and clinically-significant physical intimate partner violence.

    PubMed

    Slep, Amy M Smith; Foran, Heather M; Heyman, Richard E; Snarr, Jeffery D; Usaf Family Advocacy Research Program

    2014-12-01

    Intimate partner violence (IPV) is a significant public health concern. To date, risk factor research has not differentiated physical violence that leads to injury and/or fear (i.e., clinically significant IPV; CS-IPV) from general physical IPV. Isolating risk relations is necessary to best inform prevention and treatment efforts. The current study used an ecological framework and evaluated relations of likely risk factors within individual, family, workplace, and community levels with both CS-IPV and general IPV to determine whether they were related to one type of IPV, both, or neither for both men and women. Probable risk and promotive factors from multiple ecological levels of influence were selected from the literature and assessed, along with CS-IPV and general IPV, via an anonymous, web-based survey. The sample comprised US Air Force (AF) active duty members and civilian spouses (total N = 36,861 men; 24,331 women) from 82 sites worldwide. Relationship satisfaction, age, and alcohol problems were identified as unique risk factors (in the context of the 23 other risk factors examined) across IPV and CS-IPV for men and women. Other unique risk factors were identified that differed in prediction of IPV and CS-IPV. The results suggest a variety of both established and novel potential foci for indirectly targeting partner aggression and clinically-significant IPV by improving people's risk profiles at the individual, family, workplace, and community levels. Aggr. Behav. 9999:XX-XX, 2014. © 2014 Wiley Periodicals, Inc. PMID:25474230

  19. Identifying unique and shared risk factors for physical intimate partner violence and clinically-significant physical intimate partner violence.

    PubMed

    Slep, Amy M Smith; Foran, Heather M; Heyman, Richard E; Snarr, Jeffery D; Usaf Family Advocacy Research Program

    2015-05-01

    Intimate partner violence (IPV) is a significant public health concern. To date, risk factor research has not differentiated physical violence that leads to injury and/or fear (i.e., clinically significant IPV; CS-IPV) from general physical IPV. Isolating risk relations is necessary to best inform prevention and treatment efforts. The current study used an ecological framework and evaluated relations of likely risk factors within individual, family, workplace, and community levels with both CS-IPV and general IPV to determine whether they were related to one type of IPV, both, or neither for both men and women. Probable risk and promotive factors from multiple ecological levels of influence were selected from the literature and assessed, along with CS-IPV and general IPV, via an anonymous, web-based survey. The sample comprised US Air Force (AF) active duty members and civilian spouses (total N = 36,861 men; 24,331 women) from 82 sites worldwide. Relationship satisfaction, age, and alcohol problems were identified as unique risk factors (in the context of the 23 other risk factors examined) across IPV and CS-IPV for men and women. Other unique risk factors were identified that differed in prediction of IPV and CS-IPV. The results suggest a variety of both established and novel potential foci for indirectly targeting partner aggression and clinically-significant IPV by improving people's risk profiles at the individual, family, workplace, and community levels. Aggr. Behav. 41:227-241, 2015. © 2014 Wiley Periodicals, Inc. PMID:27541201

  20. The Influence of Individual and Partner Characteristics on the Perpetration of Intimate Partner Violence in Young Adult Relationships

    ERIC Educational Resources Information Center

    Herrera, Veronica M.; Wiersma, Jacquelyn D.; Cleveland, H. Harrington

    2008-01-01

    This study examines individual and partner characteristics associated with the perpetration of intimate partner violence (IPV) in young adult relationships with opposite sex partners. Using data from Waves 1 and 3 of the National Longitudinal Study of Adolescent Health, this study examined 1,275 young adults' heterosexual romantic relationships.…

  1. Effects of Dance on Gait and Balance in Parkinson Disease: A Comparison of Partnered and Non-Partnered Dance Movement

    PubMed Central

    Hackney, Madeleine E.; Earhart, Gammon M.

    2009-01-01

    Partnered tango dance can improve balance and gait in individuals with Parkinson disease (PD). Partnered dance may allow individuals with PD to challenge balance more than non-partnered dance. Alternatively, partnered practice could reduce balance gains because the patient may rely on the partner as a balance aid when challenged. We compared effects of partnered to non-partnered dance on balance and mobility in 39 people (11 females) with mild-moderate PD (Hoehn & Yahr stages I-III). Participants were randomly assigned to partnered or non-partnered tango and attended 1-hour classes twice per week, completing 20 lessons within 10 weeks. Balance and gait were evaluated in the weeks immediately before, immediately after, and one month after the intervention. Both groups significantly improved on the Berg Balance scale, comfortable and fast as possible walking velocity and cadence. Improvements were maintained at the one-month follow-up. The non-partnered class improved as much as the partnered class; however, Partner participants expressed more enjoyment and interest in continuing. PMID:20008820

  2. Reactions to a Partner-Assisted Emotional Disclosure Intervention: Direct Observation and Self-Report of Patient and Partner Communication

    ERIC Educational Resources Information Center

    Porter, Laura S.; Baucom, Donald H.; Keefe, Francis J.; Patterson, Emily S.

    2012-01-01

    Partner-assisted emotional disclosure is a couple-based intervention designed to help patients disclose cancer-related concerns to their spouses-partners. We previously found that, compared with an education/support control condition, partner-assisted emotional disclosure led to significant improvements in relationship quality and intimacy for…

  3. Identification of new interacting partners of the shuttling protein ubinuclein (Ubn-1)

    SciTech Connect

    Lupo, Julien; Conti, Audrey; Sueur, Charlotte; Coly, Pierre-Alain; Coute, Yohann; Hunziker, Walter; Burmeister, Wim P.; Germi, Raphaelle; Manet, Evelyne; Gruffat, Henri; and others

    2012-03-10

    We have previously characterized ubinuclein (Ubn-1) as a NACos (Nuclear and Adherent junction Complex components) protein which interacts with viral or cellular transcription factors and the tight junction (TJ) protein ZO-1. The purpose of the present study was to get more insights on the binding partners of Ubn-1, notably those present in the epithelial junctions. Using an in vivo assay of fluorescent protein-complementation assay (PCA), we demonstrated that the N-terminal domains of the Ubn-1 and ZO-1 proteins triggered a functional interaction inside the cell. Indeed, expression of both complementary fragments of venus fused to the N-terminal parts of Ubn-1 and ZO-1 was able to reconstitute a fluorescent venus protein. Furthermore, nuclear expression of the chimeric Ubn-1 triggered nuclear localization of the chimeric ZO-1. We could localize this interaction to the PDZ2 domain of ZO-1 using an in vitro pull-down assay. More precisely, a 184-amino acid region (from amino acids 39 to 223) at the N-terminal region of Ubn-1 was responsible for the interaction with the PDZ2 domain of ZO-1. Co-imunoprecipitation and confocal microscopy experiments also revealed the tight junction protein cingulin as a new interacting partner of Ubn-1. A proteomic approach based on mass spectrometry analysis (MS) was then undertaken to identify further binding partners of GST-Ubn-1 fusion protein in different subcellular fractions of human epithelial HT29 cells. LYRIC (Lysine-rich CEACAM1-associated protein) and RACK-1 (receptor for activated C-kinase) proteins were validated as bona fide interacting partners of Ubn-1. Altogether, these results suggest that Ubn-1 is a scaffold protein influencing protein subcellular localization and is involved in several processes such as cell-cell contact signalling or modulation of gene activity.

  4. Chemical profile of white wines produced from 'Greco bianco' grape variety in different Italian areas by nuclear magnetic resonance (NMR) and conventional physicochemical analyses.

    PubMed

    Caruso, Marisa; Galgano, Fernanda; Castiglione Morelli, Maria Antonietta; Viggiani, Licia; Lencioni, Livio; Giussani, Barbara; Favati, Fabio

    2012-01-11

    In this study the characterization of white wines produced from the monovarietal 'Greco bianco' grape variety is presented for the first time. A total of 40 commercial wines, from two different southern Italian regions, Calabria and Campania, from the same grape variety and two different vintages, were investigated. The analyses were performed by means of chromatographic methods, conventional analyses, and nuclear magnetic resonance (NMR) spectroscopy. No differentiation was observed according to the year of production but a significant discrimination was achieved using principal component analysis (PCA) and partial least squares-discriminant analysis (PLS-DA). In particular, PLS-DA allowed the selection of compounds (total acidity; citric, malic, succinic, and lactic acids; total polyphenol index; glucose and proline/arginine ratio) useful for differentiating the studied wines on the basis of geographical origin. PMID:22148282

  5. Nuclear World Order and Nonproliferation

    SciTech Connect

    Joeck, N

    2007-02-05

    The decision by India and Pakistan in May 1998 to conduct nuclear weapon tests and declare themselves as nuclear weapon states challenged South Asian regional stability calculations, US nonproliferation policy, and prevailing assumptions about international security. A decade later, the effects of those tests are still being felt and policies are still adjusting to the changed global conditions. This paper will consider non- and counter-proliferation policy options for the United States and Pakistan as they work as partners to prevent the transfer of nuclear technology and further nuclear proliferation.

  6. Imprecision profiling.

    PubMed

    Sadler, William A

    2008-08-01

    * Imprecision profiles express precision characteristics of an assay over a range of concentration values. They can convert large quantities of potentially complex data into an easily interpreted graphical summary. * Imprecision profile estimation does not require precisely structured data. This implies that structured method evaluation data can be easily compared with, or merged with, less structured internal quality control (QC) data (or with data from any other source). * Although originally conceived for immunoassays, imprecision profiles could, in principle, be used as a summary method with any measurement system where precision varies with level of measurand. PMID:18852854

  7. Building America Top Innovations 2013 Profile – Building America Solution Center

    SciTech Connect

    none,

    2013-09-01

    This Top Innovation profile provides information about the Building America Solution Center created by Pacific Northwest National Laboratory, a web tool connecting users to thousands of pieces of building science information developed by DOE’s Building America research partners.

  8. Intergenerational transmission of partner violence: a 20-year prospective study.

    PubMed

    Ehrensaft, Miriam K; Cohen, Patricia; Brown, Jocelyn; Smailes, Elizabeth; Chen, Henian; Johnson, Jeffrey G

    2003-08-01

    An unselected sample of 543 children was followed over 20 years to test the independent effects of parenting, exposure to domestic violence between parents (ETDV), maltreatment, adolescent disruptive behavior disorders, and emerging adult substance abuse disorders (SUDs) on the risk of violence to and from an adult partner. Conduct disorder (CD) was the strongest risk for perpetrating partner violence for both sexes, followed by ETDV, and power assertive punishment. The effect of child abuse was attributable to these 3 risks. ETDV conferred the greatest risk of receiving partner violence; CD increased the odds of receiving partner violence but did not mediate this effect. Child physical abuse and CD in adolescence were strong independent risks for injury to a partner. SUD mediated the effect of adolescent CD on injury to a partner but not on injury by a partner. Prevention implications are highlighted. PMID:12924679

  9. Leadership Profiles.

    ERIC Educational Resources Information Center

    Teach, Beverly; And Others

    1994-01-01

    Presents profiles of two leaders in the field of educational media and technology: Carolyn Guss and Mendel Sherman, both retired professors from Indiana University's program in Information Systems Technology. (KRN)

  10. Pioneer Profile.

    ERIC Educational Resources Information Center

    Butcher, Channa Beth

    1987-01-01

    Profiles Herbert A. Sweet, founder and director of Acorn Farms Day Camp (Indiana) for 44 years. Includes reminiscences about the camp's program, staffing, food, World War II, affiliation with the American Camping Association, and camps/directors of today. (NEC)

  11. TEP Power Partners Project [Tucson Electric Power

    SciTech Connect

    None, None

    2014-02-06

    The Arizona Governor’s Office of Energy Policy, in partnership with Tucson Electric Power (TEP), Tendril, and Next Phase Energy (NPE), formed the TEP Power Partners pilot project to demonstrate how residential customers could access their energy usage data and third party applications using data obtained from an Automatic Meter Reading (AMR) network. The project applied for and was awarded a Smart Grid Data Access grant through the U.S. Department of Energy. The project participants’ goal for Phase I is to actively engage 1,700 residential customers to demonstrate sustained participation, reduction in energy usage (kWh) and cost ($), and measure related aspects of customer satisfaction. This Demonstration report presents a summary of the findings, effectiveness, and customer satisfaction with the 15-month TEP Power Partners pilot project. The objective of the program is to provide residential customers with energy consumption data from AMR metering and empower these participants to better manage their electricity use. The pilot recruitment goals included migrating 700 existing customers from the completed Power Partners Demand Response Load Control Project (DRLC), and enrolling 1,000 new participants. Upon conclusion of the project on November 19, 2013; 1,390 Home Area Networks (HANs) were registered; 797 new participants installed a HAN; Survey respondents’ are satisfied with the program and found value with a variety of specific program components; Survey respondents report feeling greater control over their energy usage and report taking energy savings actions in their homes after participating in the program; On average, 43 % of the participants returned to the web portal monthly and 15% returned weekly; and An impact evaluation was completed by Opinion Dynamics and found average participant savings for the treatment period1 to be 2.3% of their household use during this period.2 In total, the program saved 163 MWh in the treatment period of 2013.

  12. Children's exposure to intimate partner violence.

    PubMed

    MacMillan, Harriet L; Wathen, C Nadine

    2014-04-01

    Children's exposure to intimate partner violence (IPV) is now recognized as a form of child maltreatment associated with significant mental health impairment. This article provides an overview of the epidemiology of children's exposure to IPV, including prevalence, risk, and protective factors and associated impairment, and a summary of assessment and interventions aimed at preventing its occurrence and responding to children and families. Information about evidence-based approaches to responding to children who present with impairment after exposure to IPV, such as posttraumatic-stress disorder symptoms, is discussed. Some of the challenges in understanding children's needs with regard to safety and protection are outlined with recommendations for future directions. PMID:24656581

  13. Partners in Science Education: SOFIA EPO Program

    NASA Astrophysics Data System (ADS)

    Backman, D.; DeVore, E.; Bennett, M.

    2003-05-01

    NASA's Stratospheric Observatory for Infrared Astronomy (SOFIA) represents a unique opportunity for education and public outreach (EPO) as the first research observatory designed to include by educators, journalists and others in research missions. The EPO program will include formal K-12 and undergraduate educational activities, informal education, public outreach, and media relations. SOFIA will carry educators on science flights, enabling them to partner with scientists and see science in action. Up to 200 formal and informal educators will participate in the SOFIA Airborne Astronomy Ambassadors (AAA) program each year. The AAAs will be sustained as a national network via continued communications and material support from the observatory's EPO program office, and will constitute a wide-spread outreach cadre for NASA and space sciences. wide-spread outreach cadre for NASA and space sciences. Scientists, engineers, and other members of the SOFIA team will partner with local teachers and visit their classrooms as a part of the SOFIA Education Partners Program. Trained via the Project ASTRO network of astronomy education sites, SOFIA team members will work with teachrs and students to forge long-lasting science education partnerships. Participating educators may fly onboard SOFIA with their scientist partners. The professors and instructors at community colleges, small colleges, and minority serving institutions teach astronomy in general education courses that include the majority of future K-12 teachers. SOFIA EPO will provide an opportunity for this important segment of the college/university faculty plus staff of science and technology centers and planetaria to learn about research astronomy through summer workshops at the observatory. Participants will be encouraged to develop partnerships with SOFIA-affiliated scientists and participate in research flights. SOFIA is being developed and will be operated for NASA by SOFIA is being developed and will be operated

  14. Biological Correlates of Intimate Partner Violence Perpetration

    PubMed Central

    Pinto, Lavinia A.; Sullivan, Eric L.; Rosenbaum, Alan; Wyngarden, Nicole; Umhau, John C.; Miller, Mark W.; Taft, Casey T.

    2013-01-01

    An extensive literature documents biological correlates of general aggression, but there has been less focus on biological correlates of intimate partner violence (IPV). The purpose of this review is to summarize the research literature to date that has reported on biological factors in IPV perpetration. We review the existing literature on four domains of biological processes that have been examined with respect to IPV perpetration, including: head injury and neuropsychology; psychophysiology; neurochemistry, metabolism and endocrinology; and genetics. We critique the literature, discuss the clinical relevance of research findings, and provide some recommendations for future biologically-oriented IPV research. PMID:23393423

  15. Hiring your next partner: AOA critical issues.

    PubMed

    Blasier, R Dale; Gagnon, Michael R; Iannotti, Joseph P; Jarvis-Selinger, Sandra

    2014-09-01

    Hiring a new partner into an orthopaedic department or group can be a daunting task. A recent American Orthopedic Association symposium sought to address three major aspects of hiring that affect orthopaedic leaders: (1) when to hire-the chairperson's role; (2) generational issues that affect hiring; and (3) the development of an initial compensation package.How does the chairperson recruit new physicians? Hiring a new partner into the academic setting requires a good deal of foresight. There must be an established game plan. Advertising and interviews need to be orchestrated. Chairpersons can find information about candidates from many unique sources. Fit within the department and community is important and must be cultivated. Spouses and families need special attention. Research candidates have individual needs. Perhaps the most important aspect of recruitment is the development of a realistic business plan. This paper provides an overview of factors to consider in managing a new hire.Generational issues are intriguing. Should they affect our hiring practices? It seems clear to established physicians that the new generation of graduates is different from their predecessors. Is this really true? Most everyone is familiar with the terms "Silent Generation," "Baby Boomers," "Generation X," and "Generation Y." Is there anything to be gained by categorizing an applicant? Is it important to hire a replica of one's self? This paper provides a thoughtful overview of generational issues as they apply to hiring new partners.Most department chairpersons are not trained as negotiators. Some preparation and experience are helpful in guiding the process of making an initial offer to a candidate. It is not all about pay. The package includes the guarantee period, expectations for the new hire, mentorship, and resources. How much should new orthopaedic academic hires be paid? Recent benchmark data from the Academic Orthopaedic Consortium suggest a mean income of $282,667 for

  16. Treaty verification with an uncertain partner

    SciTech Connect

    Weissenberger, S.

    1991-01-01

    A simple model is used to analyze the performance of a system for verifying compliance with an arms control treaty. Blue and Red are partners in to a treaty. Blue prefers to comply, but is uncertain whether Red similarly prefers compliance (in the absence of threatened violation detection). Blue's uncertainty is modeled as a probability distribution over three different Red types: Violators, Compilers, and Deterrables. Criteria are derived to determine the level at which Blue should set his detection threshold, and when it is best for Blue not to verify at all. The results involve both game-theoretic and Bayes solutions. 9 refs., 14 figs.

  17. Intimate Partner Violence Against Women in Zimbabwe.

    PubMed

    Fidan, Ahmet; Bui, Hoan N

    2016-08-01

    The present study examines intimate partner violence (IPV) reported by a sample of women in Zimbabwe to explore factors associated with the problem. Findings from the study indicate an important role of gender relationships in violence against women. The effects of gender inequalities on the likelihood of IPV vary with types of violence, but husband's patriarchal behaviors increase the likelihood of all forms of violence. The study suggests the importance of improving gender equality through public education on gender relationships, increasing women's education and economic opportunities, and eliminating customary laws that sustain gender inequality as necessary steps to combat IPV against women in Zimbabwe. PMID:26644331

  18. Gay Apps for Seeking Sex Partners in China: Implications for MSM Sexual Health.

    PubMed

    Bien, Cedric H; Best, John M; Muessig, Kathryn E; Wei, Chongyi; Han, Larry; Tucker, Joseph D

    2015-06-01

    Anti-gay stigma and harsh local environments in many low and middle-income countries (LMIC) encourage men who have sex with men (MSM) partner-seeking mobile application (gay app) use. To investigate the sexual risk profiles of gay app users and guide future HIV prevention programs, we conducted a cross-sectional online survey among 1,342 MSM in China examining associations between gay app use and sexual behaviors, including HIV and sexually transmitted disease testing. Compared to non-app users, app users were more likely to be younger, better educated, "out" about their sexual orientation, and single. They were also more likely to report multiple recent sex partners and HIV testing, but there was no difference in condomless sex between the two groups. Future research among MSM in LMIC is needed to characterize gay app use and explore its potential for future public health interventions. PMID:25572834

  19. Gay apps for seeking sex partners in China: Implications for MSM sexual health

    PubMed Central

    Bien, Cedric H.; Best, John M.; Muessig, Kathryn E.; Wei, Chongyi; Han, Larry; Tucker, Joseph D.

    2015-01-01

    Anti-gay stigma and harsh local environments in many low and middle-income countries (LMIC) encourage men who have sex with men (MSM) partner-seeking mobile application (gay app) use. To investigate the sexual risk profiles of gay app users and guide future HIV prevention programs, we conducted a cross-sectional online survey among 1,342 MSM in China examining associations between gay app use and sexual behaviors, including HIV and sexually transmitted disease (STD) testing. Compared to non-app users, app users were more likely to be younger, better educated, “out” about their sexual orientation, and single. They were also more likely to report multiple recent sex partners and HIV testing, but there was no difference in condomless sex between the two groups. Future research among MSM in LMIC is needed to characterize gay app use and explore its potential for future public health interventions. PMID:25572834

  20. Aqueous and lipid nuclear magnetic resonance metabolomic profiles of the earthworm Aporrectodea caliginosa show potential as an indicator species for environmental metabolomics.

    PubMed

    Brown, Jeffrey N; Samuelsson, Linda; Bernardi, Giuliana; Gooneratne, Ravi; Larsson, D G Joakim

    2014-10-01

    The common pasture earthworm Aporrectodea caliginosa has often been neglected in environmental metabolomics in favor of species easily bred in the laboratory. The present study assigns aqueous metabolites in A. caliginosa using high-resolution 1- and 2-dimensional nuclear magnetic resonance (NMR) spectroscopy. In total, 51 aqueous metabolites were identified, including typical amino acids (alanine, leucine, asparagine, phenylalanine), sugars (maltose, glucose), the dominant earthworm-specific 2-hexyl-5-ethyl-furansulfonate, and several previously unreported metabolites (oxoglutarate, putrescine). Examining the lesser-known earthworm lipid metabolome showed various lipid fatty acyl chains, cholesterol, and phosphatidylcholine. To briefly test if the NMR metabolomic techniques could differentiate A. caliginosa from different sites, earthworms were collected from 2 adjacent farms. Orthogonal partial least squares discriminant analysis detected metabolomic differences, suggesting the worms from the 2 sites differed in their energy metabolism, as indicated by altered levels of alanine, glutamine, glutamate, malate, fumarate, and lipids. Evidence of greater utilization of lipid energy reserves and onset of protein catabolism was also present. While the precise cause of the metabolomic differences could not be determined, the results show the potential of this species for further environmental metabolomic studies. PMID:24995628

  1. Polycystins and partners: proposed role in mechanosensitivity

    PubMed Central

    Retailleau, Kevin; Duprat, Fabrice

    2014-01-01

    Mutations of the two polycystins, PC1 and PC2, lead to polycystic kidney disease. Polycystins are able to form complexes with numerous families of proteins that have been suggested to participate in mechanical sensing. The proposed role of polycystins and their partners in the kidney primary cilium is to sense urine flow. A role for polycystins in mechanosensing has also been shown in other cell types such as vascular smooth muscle cells and cardiac myocytes. At the plasma membrane, polycystins interact with diverse ion channels of the TRP family and with stretch-activated channels (Piezos, TREKs). The actin cytoskeleton and its interacting proteins, such as filamin A, have been shown to be essential for these interactions. Numerous proteins involved in cell–cell and cell–extracellular matrix junctions interact with PC1 and/or PC2. These multimeric protein complexes are important for cell structure integrity, the transmission of force, as well as for mechanosensing and mechanotransduction. A group of polycystin partners are also involved in subcellular trafficking mechanisms. Finally, PC1 and especially PC2 interact with elements of the endoplasmic reticulum and are essential components of calcium homeostasis. In conclusion, we propose that both PC1 and PC2 act as conductors to tune the overall cellular mechanosensitivity. PMID:24687583

  2. Touch increases autonomic coupling between romantic partners

    PubMed Central

    Chatel-Goldman, Jonas; Congedo, Marco; Jutten, Christian; Schwartz, Jean-Luc

    2014-01-01

    Interpersonal touch is of paramount importance in human social bonding and close relationships, allowing a unique channel for affect communication. So far the effect of touch on human physiology has been studied at an individual level. The present study aims at extending the study of affective touch from isolated individuals to truly interacting dyads. We have designed an ecological paradigm where romantic partners interact only via touch and we manipulate their empathic states. Simultaneously, we collected their autonomic activity (skin conductance, pulse, respiration). Fourteen couples participated to the experiment. We found that interpersonal touch increased coupling of electrodermal activity between the interacting partners, regardless the intensity and valence of the emotion felt. In addition, physical touch induced strong and reliable changes in physiological states within individuals. These results support an instrumental role of interpersonal touch for affective support in close relationships. Furthermore, they suggest that touch alone allows the emergence of a somatovisceral resonance between interacting individuals, which in turn is likely to form the prerequisites for emotional contagion and empathy. PMID:24734009

  3. The male partner involved in legal abortion.

    PubMed

    Kero, A; Lalos, A; Högberg, U; Jacobsson, L

    1999-10-01

    This study comprises 75 men who have been involved in legal abortion. The men answered a questionnaire concerning living conditions and attitudes about pregnancy and abortion. Most men were found to be in stable relationships with good finances. More than half clearly stated that they wanted the woman to have an abortion while 20 stressed that they submitted themselves to their partner's decision. Only one man wanted the woman to complete the pregnancy. Apart from wanting children within functioning family units, the motivation for abortion revealed that the desire to have children depended on the ability to provide qualitatively good parenting. More than half the men had discussed with their partner what to do in event of pregnancy and half had decided to have an abortion if a pregnancy occurred. More than half expressed ambivalent feelings about the coming abortion, using words such as anxiety, responsibility, guilt, relief and grief. In spite of these contradictory feelings, prevailing expectations concerning lifestyle make abortion an acceptable form of birth control. A deeper understanding of the complexity of legal abortion makes it necessary to accept the role of paradox, which the ambivalence reflects. Obviously, men must constitute a target group in efforts to prevent abortions. PMID:10528006

  4. Reputation-based partner choice promotes cooperation in social networks

    PubMed Central

    Fu, Feng; Hauert, Christoph; Nowak, Martin A.; Wang, Long

    2009-01-01

    We investigate the cooperation dynamics attributed to the interplay between evolution of individual strategies and evolution of individual partnerships. We focus on the effect of reputation on individual's partner switching process. We assume individuals can either change their strategies by imitating their partners or adjust their partnerships based on local information about reputations. We manipulate the partner switching in two ways, that is, individuals can switch from the lowest reputation partners, either to their partners' partners who have the highest reputation (i.e., ordering in partnership) or to others randomly chosen from the entire population (i.e., randomness in partnership). We show that when individuals are able to alter their behavioral strategies and their social interaction partnerships on the basis of reputation, cooperation can prevail. We find that the larger temptation to defect and the denser the partner network, the more frequently individuals need shift their partnerships in order for cooperation to thrive. Furthermore, increasing tendency of switching to partners' partners is more likely to lead to higher level of cooperation. We show that when reputation is absent in such partner-switching process, cooperation is much less favored than that of reputation involved. Moreover, we investigate the effect of discounting individual's reputation on the evolution of cooperation. Our results highlight the importance of consideration of reputation (indirect reciprocity) on promotion of cooperation when individuals can adjust their partnerships. PMID:18850907

  5. Perceptions of partner sexual satisfaction in heterosexual committed relationships.

    PubMed

    Fallis, Erin E; Rehman, Uzma S; Purdon, Christine

    2014-04-01

    Sexual script theory implies that partners' ability to gauge one another's level of sexual satisfaction is a key factor in determining their own sexual satisfaction. However, relatively little research has examined how well partners gauge one another's sexual satisfaction and the factors that predict their accuracy. We hypothesized that the degree of bias in partner judgments of sexual satisfaction would be associated with quality of sexual communication. We further posited that emotion recognition would ameliorate the biases in judgment such that poor communicators with good emotion recognition would make less biased judgments of partner satisfaction. Participants were 84 married or cohabiting heterosexual couples who completed measures of their own and their partners' sexual satisfaction, relationship satisfaction, quality of communication about sexual issues within their relationships, and emotion recognition ability. Results indicated that both men and women tended to be accurate in perceiving their partners' levels of sexual satisfaction (i.e., partner perceptions were strongly correlated with self-reports). One sample t-tests indicated that men's perceptions of their partners' sexual satisfaction were biased such that they slightly underestimated their partners' levels of sexual satisfaction whereas women neither over- nor underestimated their partners' sexual satisfaction. However, the gender difference was not significant. Bias was attenuated by quality of sexual communication, which interacted with emotion recognition ability such that when sexual communication was good, there was no significant association between emotion recognition ability and bias, but when sexual communication was poor, better emotion recognition ability was associated with less bias. PMID:23990145

  6. Partnering with Community-Based Organizations to Reduce Intimate Partner Violence

    ERIC Educational Resources Information Center

    Bloom, Tina; Wagman, Jennifer; Hernandez, Rebecca; Yragui, Nan; Hernandez-Valdovinos, Noelia; Dahlstrom, Marie; Glass, Nancy

    2009-01-01

    Latinas experiencing intimate partner violence (IPV) often avoid formal resources due to fear, distrust, and cultural and language barriers, yet little research addresses culturally appropriate interventions for abused Latinas. To develop effective interventions, we must include abused Latinas' voices in research and collaborate with the…

  7. Actor and Partner Effects of Adolescents' Romantic Working Models and Styles on Interactions with Romantic Partners

    ERIC Educational Resources Information Center

    Furman, Wyndol; Simon, Valerie A.

    2006-01-01

    The present study examined how adolescents' and their romantic partners' romantic working models and relational styles were related to their interactions with each other. Sixty-five couples (M age=18.1 years) were observed interacting. Romantic working models were assessed in interviews about their romantic experiences; romantic styles were…

  8. 26 CFR 1.707-1 - Transactions between partner and partnership.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 8 2011-04-01 2011-04-01 false Transactions between partner and partnership. 1...) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Partners and Partnerships § 1.707-1 Transactions between partner and partnership. (a) Partner not acting in capacity as partner. A partner who engages in...

  9. Database of Ligand-Receptor Partners, a DIP subset

    DOE Data Explorer

    Graeber, Thomas G.; Eisenberg, David

    The Database of Ligand-Receptor Partners (DLRP) is a subset of DIP (Database of Interacting Proteins). The DLRP is a database of protein ligand and protein receptor pairs that are known to interact with each other. By interact we mean that the ligand and receptor are members of a ligand-receptor complex and, unless otherwise noted, transduce a signal. In some instances the ligand and/or receptor may form a heterocomplex with other ligands/receptors in order to be functional. We have entered the majority of interactions in DLRP as full DIP entries, with links to references and additional information (see the DIP User's Guide). DLRP is a web supplement for: Thomas G. Graeber and David Eisenberg. Bioinformatic identification of potential autocrine signaling loops in cancers from gene expression profiles. Nature Genetics, 29(3):295-300 (November 2001). [Quoted from the DLRP homepage at http://dip.doe-mbi.ucla.edu/dip/DLRP.cgi] Also available from this page is the DLRP chemokine subset.

  10. Employment status and intimate partner violence among Mexican women.

    PubMed

    Terrazas-Carrillo, Elizabeth C; McWhirter, Paula T

    2015-04-01

    Exploring risk factors and profiles of intimate partner violence in other countries provides information about whether existing theories of this phenomenon hold consistent in different cultural settings. This study will present results of a regression analysis involving domestic violence among Mexican women (n = 83,159). Significant predictors of domestic violence among Mexican women included age, number of children in the household, income, education, self-esteem, family history of abuse, and controlling behavior of the husband. Women's employment status was not a significant predictor when all variables were included in the model; however, when controlling behavior of the husband was withdrawn from the model, women's employment status was a significant predictor of domestic violence toward women. Results from this research indicate that spousal controlling behavior may serve as a mediator of the predictive relationship between women's employment status and domestic violence among Mexican women. Findings provide support for continued exploration of the factors that mediate experiences of domestic violence among women worldwide. PMID:25031103

  11. Expression Profile of Genes as Indicators of Developmental Competence and Quality of In Vitro Fertilization and Somatic Cell Nuclear Transfer Bovine Embryos

    PubMed Central

    Monteleone, Melisa Carolina; Mucci, Nicolas; Kaiser, German Gustavo; Brocco, Marcela; Mutto, Adrián

    2014-01-01

    Reproductive biotechnologies such as in vitro fertilization (IVF) and somatic cell nuclear transfer (SCNT) enable improved reproductive efficiency of animals. However, the birth rate of in vitro-derived embryos still lags behind that of their in vivo counterparts. Thus, it is critical to develop an accurate evaluation and prediction system of embryo competence, both for commercial purposes and for scientific research. Previous works have demonstrated that in vitro culture systems induce alterations in the relative abundance (RA) of diverse transcripts and thus compromise embryo quality. The aim of this work was to analyze the RA of a set of genes involved in cellular stress (heat shock protein 70-kDa, HSP70), endoplasmic reticulum (ER) stress (immunoglobulin heavy chain binding protein, Bip; proteasome subunit β5, PSMB5) and apoptosis (BCL-2 associated X protein, Bax; cysteine aspartate protease-3, Caspase-3) in bovine blastocysts produced by IVF or SCNT and compare it with that of their in vivo counterparts. Poly (A) + mRNA was isolated from three pools of 10 blastocysts per treatment and analyzed by real-time RT-PCR. The RA of three of the stress indicators analyzed (Bax, PSMB5 and Bip) was significantly increased in SCNT embryos as compared with that of in vivo-derived blastocysts. No significant differences were found in the RA of HSP70 and Caspase-3 gene transcripts. This study could potentially complement morphological analyses in the development of an effective and accurate technique for the diagnosis of embryo quality, ultimately aiding to improve the efficiency of assisted reproductive techniques (ART). PMID:25269019

  12. Intimate partner homicide: review and implications of research and policy.

    PubMed

    Campbell, Jacquelyn C; Glass, Nancy; Sharps, Phyllis W; Laughon, Kathryn; Bloom, Tina

    2007-07-01

    Current rates of intimate partner homicide of females are approximately 4 to 5 times the rate for male victims, although the rates for both have decreased during the past 25 years. The major risk factor for intimate partner homicide, no matter if a female or male partner is killed, is prior domestic violence. This review presents and critiques the evidence supporting the other major risk factors for intimate partner homicide in general, and for intimate partner homicide of women (femicide) in particular, namely guns, estrangement, stepchild in the home, forced sex, threats to kill, and nonfatal strangulation (choking). The demographic risk factors are also examined and the related phenomena of pregnancy-related homicide, attempted femicide, and intimate partner homicide-suicide. PMID:17596343

  13. Gainful Activity and Intimate Partner Aggression in Emerging Adulthood*

    PubMed Central

    Alvira-Hammond, Marta; Longmore, Monica A.; Manning, Wendy D.; Giordano, Peggy C.

    2014-01-01

    Although intimate partner aggression crosses social class boundaries, education and income are important predictors. Yet given that emerging adulthood is a transitional period, completed education and employment, as single measures, are not ideal indicators of socioeconomic status for young people. We examined associations between self-reports of gainful activity, defined as enrollment in school or full-time employment, and intimate partner aggression among young adults in dating, cohabiting, or married relationships (N=648). Both men and women's participation in gainful activity was negatively associated with aggression. We found that when neither partner was gainfully active, individuals reported higher frequency of physical aggression. In cases of gainful activity asymmetry, the gender of the gainfully active partner did not predict intimate partner aggression. Additionally, we found no evidence that the association between gainful activity and frequency of intimate partner aggression differed by union type. PMID:25309829

  14. Infrastructure for Personalized Medicine at Partners HealthCare

    PubMed Central

    Weiss, Scott T.; Shin, Meini Sumbada

    2016-01-01

    Partners HealthCare Personalized Medicine (PPM) is a center within the Partners HealthCare system (founded by Massachusetts General Hospital and Brigham and Women’s Hospital) whose mission is to utilize genetics and genomics to improve the care of patients in a cost effective manner. PPM consists of five interconnected components: (1) Laboratory for Molecular Medicine (LMM), a CLIA laboratory performing genetic testing for patients world-wide; (2) Translational Genomics Core (TGC), a core laboratory providing genomic platforms for Partners investigators; (3) Partners Biobank, a biobank of samples (DNA, plasma and serum) for 50,000 Consented Partners patients; (4) Biobank Portal, an IT infrastructure and viewer to bring together genotypes, samples, phenotypes (validated diagnoses, radiology, and clinical chemistry) from the electronic medical record to Partners investigators. These components are united by (5) a common IT system that brings researchers, clinicians, and patients together for optimal research and patient care. PMID:26927187

  15. Profile video

    NASA Astrophysics Data System (ADS)

    Voglewede, Paul E.; Zampieron, Jeffrey

    2009-05-01

    For unattended persistent surveillance there is a need for a system which provides the following information: target classification, target quantity estimate, cargo presence and characterization, direction of travel, and action. Over highly bandwidth restricted links, such as Iridium, SATCOM or HF, the data rates of common techniques are too high, even after aggressive compression, to deliver the required intelligence in a timely, low power manner. We propose the following solution to this data rate problem: Profile Video. Profile video is a new technique which provides all of the required information in a very low data-rate package.

  16. Intimate Partner Violence Screening and Pregnant Latinas

    PubMed Central

    Rodriguez, Michael; Shoultz, Jan; Richardson, Erin

    2009-01-01

    Little is known about factors associated with healthcare screening of Intimate Partner Violence (IPV) for Latinas during pregnancy. This study builds on current research examining IPV-associated outcomes among Latinas by analyzing 210 pregnant Latina responses to a patient survey. A multivariate logistic regression model examined factors associated with being screened for IPV. One-third of pregnant women reported being screened for IPV. Factors related to being screened for IPV are reported and did not match those associated with having experienced IPV. While most pregnant Latinas were not screened for IPV, having systematic processes in place for IPV screening and fostering good patient-provider communication may facilitate identification of IPV. Having a greater awareness of the risk factors associated with IPV may also provide cues for clinicians to better address the issue of IPV. PMID:19694355

  17. Top partners searches and composite Higgs models

    NASA Astrophysics Data System (ADS)

    Matsedonskyi, Oleksii; Panico, Giuliano; Wulzer, Andrea

    2016-04-01

    Colored fermionic partners of the top quark are well-known signatures of the Composite Higgs scenario and for this reason they have been and will be subject of an intensive experimental study at the LHC. Performing an assessment of the theoretical implications of this experimental effort is the goal of the present paper. We proceed by analyzing a set of simple benchmark models, characterized by simple two-dimensional parameter spaces where the results of the searches are conveniently visualized and their impact quantified. We only draw exclusion contours, in the hypothesis of no signal, but of course our formalism could equally well be used to report discoveries in a theoretically useful format.

  18. Uncertainty in Partner Selection for Virtual Enterprises

    NASA Astrophysics Data System (ADS)

    Crispim, José; de Sousa, Jorge Pinho

    A virtual enterprise (VE) is a temporary organization that pools the core competencies of its member enterprises and exploits fast changing market opportunities. The success of such an organization is strongly dependent on its composition, and the selection of partners becomes therefore a crucial issue. This problem is particularly difficult because of the uncertainties related to information, market dynamics, customer expectations and technology speed up. In this paper we propose an integrated approach to rank alternative VE configurations in business environments with uncertainty, using an extension of the TOPSIS method for fuzzy data, improved through the use of a stochastic multiobjective tabu search meta-heuristic. Preliminary computational results clearly demonstrate the potential of this approach for practical application.

  19. Campaigns targeting perpetrators of intimate partner violence.

    PubMed

    Cismaru, Magdalena; Lavack, Anne M

    2011-10-01

    Intimate partner violence (IPV) is a global public health concern with significant physical, emotional, and economic costs. Persuading IPV perpetrators to change their behavior could play an important role in ending violence. This article reviews and analyzes 16 campaigns targeting IPV perpetrators, created in the United States, Canada, United Kingdom, Australia, and New Zealand. Two well-known models, the Transtheoretical (Stages of Change) model and Protection Motivation theory (PMT), are combined to create the analytical framework. For each stage of change, the most salient PMT variables are outlined, the people found in that stage are described, and the most effective strategies for persuasion are posited. Together, these two models would suggest that future campaigns targeting IPV perpetrators should place a stronger emphasis on the benefits of changing and place a greater focus on increasing perpetrators' confidence that they can abstain from violence. PMID:21908438

  20. Partnering approach facilitates hazardous waste cleanup

    SciTech Connect

    Marini, R.C.; Gates, S.R.; Tunnicliffe, P.W.

    1994-12-31

    The court dockets are overflowing with lawsuits filed by parties involved in environmental restoration (hazardous waste site cleanup) projects. And it seems that no one is free from potential liability these days. Among other common litigation scenarios, remedial action contractors are suing their clients, the owners; employees and other site workers are suing their employers, the remedial action contractors; and owners are suing their designers, the engineers. In the search for viable solutions to the litigation-riddled environmental cleanup business, several options are emerging. Among them, the design/build, or turnkey approach has become common, as has the less well known, but increasingly popular partnering concept, in which the owner, engineer, and constructor form an alliance that allows them to work in concert toward common goals and under shared and properly assigned risks.

  1. Physical intimate partner violence in northern India.

    PubMed

    Ragavan, Maya I; Iyengar, Kirti; Wurtz, Rebecca M

    2014-04-01

    In this article, we examine perceptions about the definition of physical intimate partner violence (IPV) in northern India utilizing feminist perspectives as a framework. We interviewed 56 women and 52 men affiliated with a health services nongovernmental organization in the Udaipur district of Rajasthan. We transcribed, coded, and analyzed the interviews utilizing grounded theory. We found that perceptions regarding physical IPV were associated with both structural and ideological patriarchal beliefs and microlevel constructs such as alcohol use. We discovered multiple types of physical IPV in the study region, including rationalized violence (socially condoned violence perpetrated by a husband against his wife), unjustified violence (socially prohibited violence perpetrated by a husband against his wife), and majboori violence (violence perpetrated by a wife against her husband). Our results add to the breadth of research available about IPV in India and create a framework for future research and IPV prevention initiatives. PMID:24598776

  2. Strategy Guideline. Partnering for High Performance Homes

    SciTech Connect

    Prahl, Duncan

    2013-01-01

    High performance houses require a high degree of coordination and have significant interdependencies between various systems in order to perform properly, meet customer expectations, and minimize risks for the builder. Responsibility for the key performance attributes is shared across the project team and can be well coordinated through advanced partnering strategies. For high performance homes, traditional partnerships need to be matured to the next level and be expanded to all members of the project team including trades, suppliers, manufacturers, HERS raters, designers, architects, and building officials as appropriate. This guide is intended for use by all parties associated in the design and construction of high performance homes. It serves as a starting point and features initial tools and resources for teams to collaborate to continually improve the energy efficiency and durability of new houses.

  3. Intimate Partner Violence in the Great Recession.

    PubMed

    Schneider, Daniel; Harknett, Kristen; McLanahan, Sara

    2016-04-01

    In the United States, the Great Recession was marked by severe negative shocks to labor market conditions. In this study, we combine longitudinal data from the Fragile Families and Child Wellbeing Study with U.S. Bureau of Labor Statistics data on local area unemployment rates to examine the relationship between adverse labor market conditions and mothers' experiences of abusive behavior between 2001 and 2010. Unemployment and economic hardship at the household level were positively related to abusive behavior. Further, rapid increases in the unemployment rate increased men's controlling behavior toward romantic partners even after we adjust for unemployment and economic distress at the household level. We interpret these findings as demonstrating that the uncertainty and anticipatory anxiety that go along with sudden macroeconomic downturns have negative effects on relationship quality, above and beyond the effects of job loss and material hardship. PMID:27003136

  4. Identifying signs of intimate partner violence.

    PubMed

    Ali, Parveen; McGarry, Julie; Dhingra, Katie

    2016-02-01

    Intimate partner violence is a major public health and social problem that affects people everywhere. Nurses can play an important role in identifying victims who present to healthcare settings with domestic abuse-related health issues. Evidence suggests that most women who present to emergency departments have experienced domestic abuse at some point in their lives, but that only 5% are identified by healthcare professionals. To identify and respond to victims effectively, emergency nurses must understand domestic abuse and its associated complexities. This article provides an overview of these issues, including the different types of abuse, and their prevalence, causes and effects on health. The article also explores how emergency nurses can identify and manage the effects of violence at work. PMID:26853673

  5. Partner Selection for Interfirm Collaboration: The Context of Ship Design

    NASA Astrophysics Data System (ADS)

    Solesvik, Marina Z.; Encheva, Sylvia

    There is a growing body of research devoted to the issues of cooperative design. However, there are still gaps in the existing knowledge on partner selection for cooperation. This paper intends to explore partner selection issues in the context of collaborative ship design. The study aims to fill a gap in the partner selection literature by proposing a quantitative technique based on formal concept analysis. An illustrative example of the selection of a partner for a project-based alliance in a naval architect firm is presented. The study has implications for practitioners and researchers.

  6. Meeting Weight Management Goals: The Role of Partner Confirmation.

    PubMed

    Dailey, René M; Crook, Brittani; Glowacki, Elizabeth; Prenger, Erica; Winslow, Addie Anderson

    2016-12-01

    Social support research suggests romantic partners could play a vital role in the success of individuals' weight management (WM) efforts, but contradictory findings from previous research have impeded our understanding of how romantic partners influence weight management goal attainment. Employing a confirmation perspective, overweight participants (body mass index [BMI] greater than 25) who were actively trying to manage their weight (N = 53) were asked to respond to daily questionnaires for a period of 2 weeks regarding their interactions with their romantic partner. Diet, exercise, and general weight management goal accomplishment were assessed. HLM was employed to assess the independent and interactive effects of partner acceptance and challenge on each of these goals. Findings suggest that perceiving high levels of both acceptance and challenge from partners was associated with more general WM and diet goal accomplishment. However, greater attainment of exercise goals was associated with only challenge. Fluctuations in partner acceptance and challenge were also examined to determine whether consistency in confirmation behaviors was associated with WM goals. Hierarchical regressions revealed that fluctuations in acceptance, but not challenge, were linked with goal attainment. Specifically, fluctuations in acceptance were helpful for those whose partners were perceived to exhibit lower levels of acceptance, but fluctuations were detrimental for those whose partners exhibited greater acceptance. Implications for communication among couples in which one partner is attempting to lose weight are discussed. PMID:27092591

  7. Power and the pursuit of a partner's goals.

    PubMed

    Laurin, Kristin; Fitzsimons, Gráinne M; Finkel, Eli J; Carswell, Kathleen L; vanDellen, Michelle R; Hofmann, Wilhelm; Lambert, Nathaniel M; Eastwick, Paul W; Fincham, Frank D; Brown, Preston C

    2016-06-01

    We investigated how power dynamics in close relationships influence the tendency to devote resources to the pursuit of goals valued by relationship partners, hypothesizing that low (vs. high) power in relationships would lead individuals to center their individual goal pursuit around the goals of their partners. We study 2 related phenomena: partner goal prioritization, whereby individuals pursue goals on behalf of their partners, and partner goal contagion, whereby individuals identify and adopt as their own the goals that their partner pursues. We tested our ideas in 5 studies that employed diverse research methods, including lab experiments and dyadic studies of romantic partners, and multiple types of dependent measures, including experience sampling reports, self-reported goal commitment, and behavioral goal pursuit in a variety of goal domains. Despite this methodological diversity, the studies provided clear and consistent evidence that individuals with low power in their relationships are especially likely to engage in both partner goal prioritization and partner goal contagion. (PsycINFO Database Record PMID:27281354

  8. Identification of male-biased microRNA-107 as a direct regulator for nuclear receptor subfamily 5 group A member 1 based on sexually dimorphic microRNA expression profiling from chicken embryonic gonads.

    PubMed

    Miao, Nan; Wang, Xin; Hou, Yue; Feng, Yanping; Gong, Yanzhang

    2016-07-01

    Several studies indicate that sexual dimorphic microRNAs (miRNAs) in chicken gonads are likely to have important roles in sexual development, but a more global understanding of the roles of miRNAs in sexual differentiation is still needed. To this end, we performed miRNA expression profiling in chicken gonads at embryonic day 5.5 (E5.5). Among the sex-biased miRNAs validated by qRT-PCR, twelve male-biased and six female-biased miRNAs were consistent with the sequencing results. Bioinformatics analysis revealed that some sex-biased miRNAs were potentially involved in gonadal development. Further functional analysis found that over-expression of miR-107 directly inhibited nuclear receptor subfamily 5 group A member 1 (NR5a1), and its downstream cytochrome P450 family 19 subfamily A, polypeptide 1 (CYP19A1). However, anti-Mullerian hormone (AMH) was not directly or indirectly regulated by miR-107. Overall results indicate that miR-107 may specifically mediate avian ovary-development by post-transcriptional regulation of NR5a1 and CYP19A1 in estrogen signaling pathways. PMID:27036932

  9. Combined use of high-resolution α-glucosidase inhibition profiling and high-performance liquid chromatography-high-resolution mass spectrometry-solid-phase extraction-nuclear magnetic resonance spectroscopy for investigation of antidiabetic principles in crude plant extracts.

    PubMed

    Kongstad, Kenneth T; Özdemir, Ceylan; Barzak, Asmah; Wubshet, Sileshi G; Staerk, Dan

    2015-03-01

    Type 2 diabetes is a metabolic disorder affecting millions of people worldwide, and new drug leads or functional foods containing selective α-glucosidase inhibitors are needed. Crude extract of 24 plants were assessed for α-glucosidase inhibitory activity. Methanol extracts of Cinnamomum zeylanicum bark, Rheum rhabarbarum peel, and Rheum palmatum root and ethyl acetate extracts of C. zeylanicum bark, Allium ascalonicum peel, and R. palmatum root showed IC50 values below 20 μg/mL. Subsequently, high-resolution α-glucosidase profiling was used in combination with high-performance liquid chromatography-high-resolution mass spectrometry-solid-phase extraction-nuclear magnetic resonance spectroscopy for identification of metabolites responsible for the α-glucosidase inhibitory activity. Quercetin (1) and its dimer (2), trimer (3), and tetramer (4) were identified as main α-glucosidase inhibitors in A. ascalonicum peel, whereas (E)-piceatannol 3'-O-β-D-glucopyranoside (5), (E)-rhapontigenin 3'-O-β-D-glucopyranoside (6), (E)-piceatannol (8), and emodin (12) were identified as main α-glucosidase inhibitors in R. palmatum root. PMID:25652946

  10. SI – SRH Sexual-risk factors of partner age-discordance in adolescent girls and their male partners

    PubMed Central

    Morrison-Beedy, Dianne; Xia, Yinglin; Passmore, Denise

    2013-01-01

    Aim and objectives To investigate differences in sexual-risk factors between adolescent girls reporting similar-aged or older sex partners. Background Adolescent girls are at significant risk for heterosexual-acquired HIV infection and other long term reproductive health issues. Sexual partner age-discordance in teen girls has been correlated with STIs, lack of protection, multiple partners, and earlier age of sexual transition. Design A descriptive study comparing girls currently involved with age-discordant partners to those with similar-aged partners. Two-sample t-test for continuous variables and for categorical variables, Chi-square or Fisher exact test were used to compare groups. Methods Baseline data from 738 sexually-active, urban, adolescent girls ages 15 to 19, were analyzed to determine which behaviors were more likely to occur in girls with older partners. Data were collected as part of a gender specific HIV-prevention intervention in a randomized controlled trial tailored to adolescent girls. Results Multiple reported sexual risk behaviors were found to significantly differ between the two groups at baseline. Overall, girls with older partners had more episodes of sexual instances (vaginal, anal, and oral). Specific sexual risk behaviors were found to be statistically significant between the two groups. Girls with older partners started having sex at earlier ages, had more lifetime sexual partners, higher incidents of STIs and were reluctant to discuss using condoms with their partners. Girls with similar-aged partners were less willing to engage in risky sexual behaviors. Conclusions Findings from this investigation support data from other studies. Relationships with older male partners place adolescent girls at increased risk for HIV/STIs and unintended pregnancy. Relevance to clinical practice Adolescent girls in age-discordant relationships are at risk for immediate and long term sexual health morbidities. Identifying girls who are at increased

  11. Romantic partners in a market perspective: expectations about what ensures a highly desirable partner.

    PubMed

    Castro, Felipe N; Hattori, Wallisen T; Yamamoto, Maria Emília; Lopes, Fívia A

    2013-10-01

    This study used the biological market perspective and influential statistical models from the marketing field to investigate males' and females' expectations regarding which combination of characteristics are most relevant in ensuring desirable partnerships for same-sex individuals. Thus, 358 Brazilian undergraduates assessed eight descriptions of same-gender stimulus targets (formulated with different levels of physical attractiveness, social skills, and current or prospective social status) and evaluated the overall desirability of the targets' expected or probable partners. From the possible combinations, three groups emerged: for one group, mainly composed of men, status characteristics were the most important attributes; for the others, mostly composed of women, social skills or physical characteristics were identified as most important in appealing to a desirable partner. This work expands the understanding of variability in male and female romantic expectations, and its implications are discussed from an evolutionary perspective. PMID:24597452

  12. Between rigidity and chaos: worldviews of partners experiencing intimate partner violence.

    PubMed

    Enosh, Guy; Eisikovits, Zvi; Gross, Chen

    2013-09-01

    The goal of this article was to examine the worldviews of cohabiting or married men and women who experienced domestic violence in their relationships. The study was based on content analysis of in-depth interviews with 48 men and women (24 couples), who were living together after experiencing at least one violent event in their relationships over the previous 12 months. Using constructivist grounded theory, the authors examined the deep structure of the ways by which partners living with intimate partner violence constructed their world. The men and women under study constructed heuristic models in two major life domains-psychological processes and how the world works overall. The analysis has revealed two axes resulting in four worldviews. The two axes were the construction of the world and the construction of the mind. Constructions of the mind ranged from chaotic to deterministic. Constructions of external reality ranged from static to fluid and uncontrollable. The theoretical model developed suggested four different types of basic worldviews. The suggested typology was examined in relation to existing typologies in the field of intimate partner violence and in relation to future research and interventions. PMID:23479434

  13. Profiles of sibling bullying.

    PubMed

    Skinner, Jessica A; Kowalski, Robin M

    2013-05-01

    Considerable research has been done on childhood bullying, including its antecedents and consequences. Yet, with all of the attention on bullying, particularly school bullying, sibling bullying has been vastly overlooked. Sibling bullying is a type of violence prevalent in the lives of most children, but little is known about the phenomenon. The purpose of this study was to profile sibling bullying by examining prevalence rates, the extent to which siblings perceive sibling bullying to be normative, and victim-perpetrator differences in perceptions of sibling bullying. Twenty-seven sibling pairs who wrote stories about personal experiences of sibling bullying and victimization completed questionnaires about these experiences and responded to their sibling partners' stories. Of the siblings surveyed, 78% reported being bullied by their sibling and 85% reported bullying their sibling during their childhood. This is far greater than published statistics on peer bullying. Not surprisingly, victims viewed sibling bullying more negatively than perpetrators. Sadly, there was a norm of acceptance of sibling bullying among most of the sibling pairs. Practical implications are discussed. PMID:23348680

  14. Patent profiles

    SciTech Connect

    Not Available

    1980-01-01

    This report presents profiles of US patents in the area of solar energy technology, and in the related areas of wind, geothermal and tide and wave energy. Each profile is divided into three parts. The first part identifies the area which is examined, lists the pertinent US Patent Classification(s), and graphically illustrates patent activity across a designated 10-year span. The second part tabulates the data upon which the graphs of the first part were based, provides a list of assignees for the period 1969 to 1978 both by the number of patents and alphabetically, and presents on alphabetical listing of inventors of unassigned patents. The third part updates the preceding material for the period January-October 1979. (SPH)

  15. Psychopathology and Marital Satisfaction: The Importance of Evaluating Both Partners

    ERIC Educational Resources Information Center

    Whisman, Mark A.; Uebelacker, Lisa A.; Weinstock, Lauren M.

    2004-01-01

    Using path analysis and hierarchical linear modeling, the authors evaluated the associations between both partners' level of depression and anxiety, as measured by Minnesota Multiphasic Personality Inventory-2 (MMPI-2) content scales, and both partners' level of marital satisfaction among married couples (N = 774) that participated in the MMPI…

  16. Partners in Quality: Communities = Partenaires pour la qualite: Collectivites.

    ERIC Educational Resources Information Center

    Kaiser, Barbara; Rasminsky, Judy Sklar

    Partners in Quality is a research and development project sponsored by the Canadian Child Care Federation and its affiliates to explore how child care providers, parents, and other partners can work together to support and improve quality in child care. This booklet, in both English and French, is the fourth in a series to support child care…

  17. Attitudes toward Intimate Partner Violence in Dating Relationships

    ERIC Educational Resources Information Center

    Fincham, Frank D.; Cui, Ming; Braithwaite, Scott; Pasley, Kay

    2008-01-01

    Prevention of intimate partner violence on college campuses includes programs designed to change attitudes, and hence, a scale that assesses such attitudes is needed. Study 1 (N = 859) cross validates the factor structure of the Intimate Partner Violence Attitude Scale-Revised using exploratory factor analysis and presents initial validity data on…

  18. Intimate Partner Violence: Building Resilience with Families and Children

    ERIC Educational Resources Information Center

    Wortham, Thomasine T.

    2014-01-01

    Intimate partner violence includes physical, emotional, or sexual maltreatment from an intimate partner that may include name-calling, hitting, controlling behaviors, use of weapons, rape, intimidation, and a plethora of other physical and emotional tactics (Kress, Protivnak, & Sadlak, 2008; United States Department of Justice, 2013). Such…

  19. 78 FR 69802 - Partner Vetting in USAID Assistance; Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-21

    ...; Email: ghigginbotham@usaid.gov . Correction In the Federal Register of August 29, 2013, in FR Doc. 2013... DEVELOPMENT 22 CFR Part 226 RIN 0412-AA71 Partner Vetting in USAID Assistance; Correction AGENCY: Agency for... additional 15 days to provide comments on its proposed Partner Vetting in USAID Assistance Rule. There was...

  20. 77 FR 77070 - Black Bear Hydro Partners, LLC;

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-31

    ... Energy Regulatory Commission Black Bear Hydro Partners, LLC; Notice of Intent To File License Application...-filing Process. b. Project No.: 2727-086. c. Dated Filed: October 24, 2012. d. Submitted By: Black Bear Hydro Partners, LLC (Black Bear Hydro). e. Name of Project: Ellsworth Hydroelectric Project. f....

  1. Care Partner Responses to the Onset of Mild Cognitive Impairment

    ERIC Educational Resources Information Center

    Blieszner, Rosemary; Roberto, Karen A.

    2010-01-01

    Purpose: We examined characteristics, responses, and psychological well-being of care partners who support and assist older adults recently diagnosed with mild cognitive impairment (MCI). Design and Methods: Based on a sample of 106 care partners of community residents diagnosed with MCI at memory clinics, we conducted face-to-face interviews…

  2. 45 CFR 162.915 - Trading partner agreements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 1 2012-10-01 2012-10-01 false Trading partner agreements. 162.915 Section 162.915 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES ADMINISTRATIVE DATA STANDARDS AND RELATED REQUIREMENTS ADMINISTRATIVE REQUIREMENTS General Provisions for Transactions § 162.915 Trading partner agreements. A covered entity must not enter...

  3. Prevalence and Correlates of Partner Violence among South African Adolescents

    ERIC Educational Resources Information Center

    Flisher, Alan J.; Myer, Landon; Merais, Adele; Lombard, Carl; Reddy, Priscilla

    2007-01-01

    Background: Little is known about the prevalence of partner violence among adolescents, nor of the factors with which it is associated. The objectives of this study were to document prevalence rates for partner violence among high school students in Cape Town, and to explore factors that are associated with such violence. Method: The sample…

  4. Writing Partners: Expanding the Audiences for Student Writing.

    ERIC Educational Resources Information Center

    Gillis, Candida

    1994-01-01

    Describes how one English teacher developed an approach to teaching writing that pairs student writers with writers in the community outside the school. Outlines the features of this writing partners project, including the responsibilities of each partner. Argues that such programs foster writer skill and self-esteem. (HB)

  5. Targets of Partner Violence: The Importance of Understanding Coping Trajectories

    ERIC Educational Resources Information Center

    Arriaga, Ximena B.; Capezza, Nicole M.

    2005-01-01

    Partner violence causes many negative outcomes for the target of the violence. Preventing negative outcomes in part hinges on altogether preventing the violence from occurring. There have been advances in violence prevention that the authors briefly review. However, some of the most notable advances focus on dealing with partner violence once it…

  6. A Professor's Life after Becoming the University Presidential Partner

    ERIC Educational Resources Information Center

    Vargas, Juanita Gamez

    2011-01-01

    The purpose of this qualitative study was to identify a public, state-supported university's role expectations of the presidential partner. The study identified various challenges and obstacles, as well as useful strategies for retaining the presidential partner's professional identity as a professor. This paper will provide a glossary of…

  7. Associating Pregnancy with Partner Violence against Chinese Women

    ERIC Educational Resources Information Center

    Chan, Ko Ling; Brownridge, Douglas A.; Tiwari, Agnes; Fong, Daniel Y. T.; Leung, Wing Cheong; Ho, Pak Chung

    2011-01-01

    The present study discusses if pregnancy is a risk factor for intimate partner violence using a large, representative sample containing detailed information on partner violence including physical and sexual abuse as well as perpetrator-related risk factors. Data from a representative sample of 2,225 men were analyzed. The self-reported prevalence…

  8. The Adapted Dance Process: Planning, Partnering, and Performing

    ERIC Educational Resources Information Center

    Block, Betty A.; Johnson, Peggy V.

    2011-01-01

    This article contains specific planning, partnering, and performing techniques for fully integrating dancers with special needs into a dance pedagogy program. Each aspect is discussed within the context of the domains of learning. Fundamental partnering strategies are related to each domain as part of the integration process. The authors recommend…

  9. 75 FR 27551 - Keystone Energy Partners, LP; Notice of Filing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-17

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Keystone Energy Partners, LP; Notice of Filing May 10, 2010. Take notice that on December 16, 2009, Keystone Energy Partners, LP submit for filing an Updated Market...

  10. Trauma Symptoms among Infants Exposed to Intimate Partner Violence

    ERIC Educational Resources Information Center

    Bogat, G. Anne; DeJonghe, Erika; Levendosky, Alytia A.; Davidson, William S.; von Eye, Alexander

    2006-01-01

    Objective: To determine whether infants have a traumatic response to intimate partner violence (male violence toward their female partner; IPV) experienced by their mothers, two questions were explored: (1) Is the number of infant trauma symptoms related to the infant's temperament and the mother's mental health? (2) Does severity of violence…

  11. Do Love Styles Predict Lifetime Number of Sex Partners?

    ERIC Educational Resources Information Center

    Hans, Jason D.

    2008-01-01

    The relationship between love styles and lifetime number of sexual partners was explored using survey data from 507 college students. Love styles significantly (p less than 0.001) contributed to the prediction of number of lifetime sex partners after controlling for demographic characteristics and attitudes toward sexually transmitted infections.…

  12. The Paradox of Support: Charter Schools and Their Institutional Partners.

    ERIC Educational Resources Information Center

    Jacobowitz, Robin

    Nonprofit organizations, private foundations, and for-profit corporations interested in shaping public education regularly partner with charter schools in New York. State law allows charter schools to pursue external partners to help meet their fiscal, facilities, operational, and instructional needs. This qualitative study of 10 schools in New…

  13. 77 FR 100 - Caledonia Energy Partners, LLC; Notice of Application

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-03

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Caledonia Energy Partners, LLC; Notice of Application Take notice that on December 16, 2011, Caledonia Energy Partners, LLC (Caledonia), 20329 Highway 249, Suite 400, Houston,...

  14. Intimate Partner Violence and Belief Systems in Liberia

    ERIC Educational Resources Information Center

    Allen, Mary; Devitt, Catherine

    2012-01-01

    Intimate partner violence is endemic in parts of the African continent. A small scale survey (n = 229) was conducted in 2009 in Northern Liberia, West Africa, to determine the prevalence and nature of intimate partner violence, and the cultural beliefs and gender norms that underpin respondent experiences and views towards intimate partner…

  15. The Role of Partners for Employees' Recovery during the Weekend

    ERIC Educational Resources Information Center

    Hahn, Verena C.; Binnewies, Carmen; Haun, Sascha

    2012-01-01

    We examined the effects of positive and negative experiences with the partner (absorption in joint activities and conflict with the partner) during the weekend on affective states at the beginning of the following work week and tested whether recovery experiences (psychological detachment, relaxation, and mastery experiences) mediated these…

  16. Partners in Quality: Infrastructure = Partenaires pour la qualite: Infrastructure.

    ERIC Educational Resources Information Center

    Kaiser, Barbara; Rasminsky, Judy Sklar

    Partners in Quality is a research and development project sponsored by the Canadian Child Care Federation and its affiliates to explore how child care providers, parents, and other partners can work together to support and improve quality in child care. This booklet, in both English and French, is the third in a series to support child care…

  17. Female Intimate Partner Violence Survivors' Experiences with Accessing Resources

    ERIC Educational Resources Information Center

    McLeod, Amy L.; Hays, Danica G.; Chang, Catherine Y.

    2010-01-01

    This phenomenological study investigates the types of personal and community resources that female intimate partner violence (IPV) survivors used when leaving an abusive male partner. Three African American and 2 European American IPV survivors, ages 24 to 38 years, described positive and negative experiences with social support, personal…

  18. Gender Differences in Expectations of Self and Future Partner.

    ERIC Educational Resources Information Center

    Ganong, Lawrence H.; Coleman, Marilyn

    1992-01-01

    Investigated expectations that 131 single female and 103 male college students had for themselves and their future marital partners. Genders did not differ on expectations for personal success but did differ on expectations for success of future marital partner. Women expected more success for future husbands than men expected for wives.…

  19. 75 FR 30018 - Hudson Transmission Partners, LLC; Notice of Filing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-28

    ... Energy Regulatory Commission Hudson Transmission Partners, LLC; Notice of Filing May 20, 2010. Take notice that on May 19, 2010, Hudson Transmission Partners, LLC filed an application requesting the... section 212.4(c) and Attachment O, section 6.5 of the PJM Open Access Transmission Tariff, PJM OATT...

  20. 78 FR 49748 - Hudson Transmission Partners, LLC; Notice of Filing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-15

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Hudson Transmission Partners, LLC; Notice of Filing Take notice that on July 12, 2013, Hudson Transmission Partners, LLC filed a request for exemption from, or waiver of,...

  1. Differences between Partners from Heterosexual, Gay, and Lesbian Cohabiting Couples

    ERIC Educational Resources Information Center

    Kurdek, Lawrence A.

    2006-01-01

    Partners from four types of couples without children (gay unmarried, lesbian unmarried, heterosexual unmarried, and heterosexual married, Ns=1,412, 1,310, 1,036, and 1,728, respectively) were compared to partners from heterosexual married couples with children ("N"= 3,116) on mean levels of variables from a model of relationship adjustment as well…

  2. Middle School Aggression and Subsequent Intimate Partner Physical Violence

    ERIC Educational Resources Information Center

    O'Donnell, Lydia; Stueve, Ann; Myint-U, Athi; Duran, Richard; Agronick, Gail; Wilson-Simmons, Renee

    2006-01-01

    This study examined the relationship between middle-school aggressive behaviors and young adults' experiences as victims and perpetrators of intimate partner physical violence. As part of the Reach for Health longitudinal study, surveys were conducted with 977 8th graders who were resurveyed as young adults, when lifetime partner violence was…

  3. Developing Teacher Inquiry in Partner Schools through Preservice Teacher Research.

    ERIC Educational Resources Information Center

    Duffield, Judith A.; Townsend, Stephanie S.

    1999-01-01

    Demonstrates how a graduate-level Initial Teacher Education Program at one university and its 12 partner schools conducts teacher research to promote educational renewal, describing a required teacher inquiry course and its implications for the partner schools and the students and teachers involved. Other efforts related to the partnership and…

  4. 76 FR 68745 - Seneca Power Partners, L.P.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-07

    ... Energy Regulatory Commission Seneca Power Partners, L.P. v. New York Independent System Operator, Inc... Power Act, 16 U.S.C. 824e and 825e and Rule 206 of the Federal Energy Regulatory Commission's (Commission) Rules of Practice and Procedures, 18 CFR 385.206, Seneca Power Partners, L.P. (Complainant)...

  5. Parenting and Women Arrested for Intimate Partner Violence

    ERIC Educational Resources Information Center

    Simmons, Catherine A.; Lehmann, Peter; Dia, David A.

    2010-01-01

    Exploring the relationship between parenting and women's use of violence the current study surveyed 106 mothers arrested for intimate partner violence (IPV) related crimes on parenting styles and attitudes toward when using violence against their partner is justified. Findings indicate parenting styles indicative of low belief in using physical…

  6. Romantic Partner Selection and Socialization during Early Adolescence

    ERIC Educational Resources Information Center

    Simon, Valerie A.; Aikins, Julie Wargo; Prinstein, Mitchell J.

    2008-01-01

    This prospective study examined romantic partner selection and socialization among a sample of 78 young adolescents (6th-8th graders). Independent assessments of adolescent and romantic partner adjustment were collected before and after relationships initiated via peer nomination and self-report. Prior to their relationship, adolescents and…

  7. Age Got to Do With It? Partner Age Difference, Power, Intimate Partner Violence, and Sexual Risk in Urban Adolescents

    PubMed Central

    Volpe, Ellen M.; Hardie, Thomas L.; Cerulli, Catherine; Sommers, Marilynn S.; Morrison-Beedy, Dianne

    2013-01-01

    Adolescent girls with older male main partners are at greater risk for adverse sexual health outcomes than other adolescent girls. One explanation for this finding is that low relationship power occurs with partner age difference. Using a cross-sectional, descriptive design, we investigated the effect of partner age difference between an adolescent girl and her male partner on sexual risk behavior through the mediators of sexual relationship power, and physical intimate partner violence (IPV), and psychological IPV severity. We chose Blanc’s framework to guide this study as it depicts the links among demographic, social, economic, relationship, family and community characteristics, and reproductive health outcomes with gender-based relationship power and violence. Urban adolescent girls (N = 155) completed an anonymous computer-assisted self-interview survey to examine partner and relationship factors’ effect on consistent condom use. Our sample had an average age of 16.1 years with a mean partner age of 17.8 years. Partners were predominantly African American (75%), non-Hispanic (74%), and low-income (81%); 24% of participants reported consistent condom use in the last 3 months. Descriptive, correlation, and multiple mediation analyses were conducted. Partner age difference was negatively associated with consistent condom use (−.4292, p < .01); however, the indirect effects through three proposed mediators (relationship power, physical IPV, or psychological IPV severity) were not statistically significant. Further studies are needed to explore alternative rationale explaining the relationship between partner age differences and sexual risk factors within adolescent sexual relationships. Nonetheless, for clinicians and researchers, these findings underscore the heightened risk associated with partner age differences and impact of relationship dynamics on sexual risk behavior. PMID:23345572

  8. Intimate partner violence: what do movies have to teach us?

    PubMed

    Lenahan, Patricia M

    2009-06-01

    Intimate partner violence is one of the most pervasive global public health problems affecting women. It results in untold costs to the healthcare system and is positively linked to eight out of ten leading indicators for Healthy People 2010. Intimate partner violence also is one of the factors associated with adverse childhood experiences that result in negative healthcare behaviours. Intimate partner violence has been the subject of film, made for television movies and music videos. The use of film as an innovative tool to teach about common health and mental health disorders is well-documented. Film also has been used as an adjunctive therapeutic tool in counselling. This paper will provide an overview of intimate partner violence, its portrayal in popular film and ways in which educators may use film to teach intimate partner violence-related topics. PMID:19459093

  9. Body ideals for heterosexual romantic partners: gender and sociocultural influences.

    PubMed

    Murnen, Sarah K; Poinsatte, Katherine; Huntsman, Karen; Goldfarb, Jesse; Glaser, Daniel

    2015-01-01

    In the present study, heterosexual college women (N=327) and men (N=160) were asked about their body type preferences for (hypothetical) romantic partners. Participants chose a particular silhouette value as ideal for a romantic partner, and rated how important it was to them for their partner to have this ideal body type. Men placed more importance on the body silhouette they chose for a partner than women did, and men's importance ratings were positively associated with the rated sexual permissiveness of their peer group and their total media use. Consuming sports media and watching reality television were the best media predictors of men's judgments about women's bodies. Less variability was explained in women's preferences for men partners' bodies, but endorsing adversarial sexual attitudes was positively related to judging the ideals chosen for men's bodies as important. Results were interpreted within both evolutionary and sociocultural theoretical frameworks. PMID:25462878

  10. Role of Partner Novelty in Sexual Functioning: A Review.

    PubMed

    Morton, Heather; Gorzalka, Boris B

    2015-01-01

    This review investigates whether sexual desire and arousal decline in response to partner familiarity, increase in response to partner novelty, and show differential responding in men and women. These questions were considered through the perspective of two leading evolutionary theories regarding human mating strategies: sexual strategies theory and attachment fertility theory. The hypotheses emerging from these theories were evaluated through a critical analysis of several areas of research including habituation of arousal to erotic stimuli, preferences regarding number of sexual partners, the effect of long-term monogamous relationships on sexual arousal and desire, and prevalence and risk factors associated with extradyadic behavior. The current literature best supports the predictions made by sexual strategies theory in that sexual functioning has evolved to promote short-term mating. Sexual arousal and desire appear to decrease in response to partner familiarity and increase in response to partner novelty in men and women. Evidence to date suggests this effect may be greater in men. PMID:25222339

  11. Experiences of female partners of masculine identifying trans persons

    PubMed Central

    Theron, Liesl; Collier, Kate L.

    2013-01-01

    This study explores the intimate relationship experiences of cisgender (i.e., not transgender) female partners of masculine identifying transgender persons, with a particular focus on these partners’ self-understanding of their sexual orientation. Limited research about this topic has been conducted to date. Semi-structured interviews were conducted with eight South African women who are or have been cisgender female partners of masculine identifying trans persons. Although the interviews showed that the relationship experiences of female partners of masculine identifying trans persons are diverse, several common themes emerged in the narratives. The way that participants labelled their sexual orientation did not change from before to after their relationship with a transgender partner. The participants reported varied family and community responses to their relationships. Specific emotional and informational support needs for women with transgender partners were identified. PMID:23668602

  12. Secondary traumatization in partners and parents of Dutch peacekeeping soldiers.

    PubMed

    Dirkzwager, Anja J E; Bramsen, Inge; Adèr, Herman; van der Ploeg, Henk M

    2005-06-01

    This study examines secondary traumatization among 708 partners and 332 parents of Dutch peacekeepers (i.e., personnel who participated in military actions implemented by international organizations such as the United Nations). Partners or parents of peacekeepers with 4 levels of posttraumatic stress symptoms were compared on posttraumatic stress, health problems, the quality of the marital relationship, and social support. In comparison with partners of peacekeepers without posttraumatic stress disorder (PTSD) symptoms, partners of peacekeepers with PTSD symptoms reported more sleeping and somatic problems, reported more negative social support, and judged the marital relationship as less favorable. No significant differences were found for parents. Thus, peacekeepers' stress reactions were related to various problems of their partners. A systemic approach to the treatment of persons with PTSD appears appropriate. PMID:15982097

  13. Patterns of misreporting intimate partner violence using matched pairs.

    PubMed

    Wenger, Marin R

    2015-01-01

    Intimate partner violence (IPV) is an issue of serious public concern. However, policy interventions and theoretical development have been complicated by mixed evidence about whether men or women experience higher levels of IPV. Some of this discrepancy arises from measurement and whether abuse and victimization are asked of one or both partners. This study uses matched partner data from 1,393 heterosexual couples collected in Wave IIIof the National Longitudinal Study of Adolescent to Adult Health to examine partner IIV reporting discrepancies and develop hypotheses for why such discrepancies might exist. Consistent with expectations, the findings suggest that research on the prevalence of IIV should rely on reports from both partners, rather than just one, and that gendered patterns of social desirability create differences in men's and women's IPV reporting. PMID:25929136

  14. How to choose a new partner in general practice.

    PubMed Central

    King, J; Whitfield, M

    1990-01-01

    OBJECTIVE--To provide a guide to choosing a new partner in general practice by using psychometric assessments. DESIGN--A descriptive account of the experience of one practice. SETTING--A general practice in Bristol. RESULTS--The partners found that using a psychologist to assess both themselves and the candidates facilitated the selection process. During the pre-interview stage the partners learnt about the dynamics of the practice and their own personalities. The examination of the candidates by an outside assessor as well as the partners gave a sense of security and a certainty that mistakes were unlikely to be made. CONCLUSION--More practices should consider adopting a selection process using psychometric assessments when appointing a new partner. PMID:2271828

  15. Food transfers in capuchin monkeys: an experiment on partner choice.

    PubMed

    Sabbatini, Gloria; De Bortoli Vizioli, Aurora; Visalberghi, Elisabetta; Schino, Gabriele

    2012-10-23

    Although most primates live in groups, experiments on reciprocity usually test individuals in dyads. This could hide the processes emerging in richer social settings, reducing the ecological validity of the results. We run an experiment on reciprocal food transfers testing capuchin monkeys (Cebus apella) in triads, so that subjects could choose to allow access to their food to either of their two partners. We tested the hypothesis that partner choice was related to a comparison of long-term social bonds with the two partners, more than to a comparison of recent food transfer events from the two partners. The results confirmed this hypothesis, thus supporting the notion that reciprocal partner preferences are based on long-term accounts of benefits that have been exchanged. PMID:22832127

  16. Food transfers in capuchin monkeys: an experiment on partner choice

    PubMed Central

    Sabbatini, Gloria; De Bortoli Vizioli, Aurora; Visalberghi, Elisabetta; Schino, Gabriele

    2012-01-01

    Although most primates live in groups, experiments on reciprocity usually test individuals in dyads. This could hide the processes emerging in richer social settings, reducing the ecological validity of the results. We run an experiment on reciprocal food transfers testing capuchin monkeys (Cebus apella) in triads, so that subjects could choose to allow access to their food to either of their two partners. We tested the hypothesis that partner choice was related to a comparison of long-term social bonds with the two partners, more than to a comparison of recent food transfer events from the two partners. The results confirmed this hypothesis, thus supporting the notion that reciprocal partner preferences are based on long-term accounts of benefits that have been exchanged. PMID:22832127

  17. Sex coaching for physicians: combination treatment for patient and partner.

    PubMed

    Perelman, M A

    2003-10-01

    Physicians dealing with sexual dysfunction (SD) must consider the psychological and behavioral aspects of their patient's diagnosis and management, as well as organic causes and risk factors. Integrating sex therapy and other psychological techniques into their office practice will improve effectiveness in treating SD. This presentation provides information about the psychological forces of patient and partner resistance, which impact patient compliance and sex lives beyond organic illness and mere performance anxiety. Four key areas are reviewed: (1). 'Sex coaching for physicians' uses the 'Cornell Model' for conceptualizing and treating SD. A 5-min 'sex status,' manages 'time crunch' by rapidly identifying common causes of sexual dysfunction (insufficient stimulation, depression, etc). (2). Augmenting pharmacotherapy with sex therapy when treating erectile dysfunction (ED) specifically, or SD generally is stressed. Sex therapy is useful as a monotherapy or an adjunctive treatment and is often the 'combination therapy' of choice when treating SD. The following therapeutic integrations are highlighted: modifying patient's initial expectations; sexual pharmaceuticals use as a therapeutic probe; 'follow-up' to manage noncompliance and improve outcome; relapse prevention. (3). Issues specific to the role of the partner of the ED patient are described. The physician must appreciate the role of couple's issues in causing and/or exacerbating the ED and the impact of the ED on the patient/partner relationship. Successful treatment requires a supportive available sexual partner, yet partner cooperation may be independent of partner attendance during the office visit. Preliminary data from a survey of SMSNA members practice patterns, regarding partner issues, is presented and discussed. The importance of evoking partner support and cooperation independent of actual attendance during office visits is emphasized. (4). Finally, the need for more patient and partner educational

  18. Sexual discordance and sexual partnering among heterosexual women.

    PubMed

    Nield, Jennifer; Magnusson, Brianna; Brooks, Christopher; Chapman, Derek; Lapane, Kate L

    2015-05-01

    This study examined characteristics of self-identified heterosexual women who were concordant or discordant in their sexual behavior and the association of discordance and sexual partnering among those aged 15-44 years from the 2006-2010 National Survey of Family Growth (n = 7,353). Sexual concordance was defined as reporting a heterosexual identity and no female partners in the past year; discordance was reporting a heterosexual identity and having at least one female partner in the past year. Sexual partnering was defined as being concurrent, serially monogamous or monogamous with a male partner in the previous year. Polytomous logistic regression models evaluated the association between sexual discordance and sexual partnering. Among self-identified heterosexual, sexually active women, 11.2 % reported ever having had a same sex partner. Heterosexually discordant women who had both male and female partners in the previous year were 5.5 times as likely to report having a concurrent relationship (95 % CI 2.77-11.09) and 2.4 times as likely to report engaging in serially monogamous relationships (95 % CI 1.19-4.97) with male partners. Discordance between heterosexual identity and same sex behavior is a factor in risky behaviors. Women who have sex with women and men may act as bridges for the transmission of STDs, particularly to their female partners. Sexual education should include information inclusive of non-heteronormative behaviors and identities to provide sexual minorities with the tools and information they need. Clinical guidelines should ensure that all women are offered counseling and screening for reproductive and sexual health. PMID:24718674

  19. Partnering for Geospatial Innovations in Indian Country

    NASA Astrophysics Data System (ADS)

    Jhon Goes in Center, . D.

    2003-12-01

    In the spirit of collaboration and reciprocity, Sinte Gleska University on the Rosebud Reservation of South Dakota will present recent developments, experiences, insights and a vision for education in Native America. As a thirty year young institution, Sinte Gleska University is founded by a strong vision of ancestral leadership and the values of the Lakota Way of Life. A recent relationship building endeavor that utilized a recent Executive Order to empower federal agencies to work hand in hand with tribal colleges has resulted in a formal Memorandum of Understanding with the United States Geologic Survey. This relationship has paved the way toward significant progress that is measured in the enhanced educational services and relevant research for Sinte Gleska University and the Lakota Nation. As an institution of higher learning for the region in the Great Plains, SGU's leadership is unparalleled. Sinte Gleska University proposes to share a vision of collaboration with not only sister institutions but with the greater national and global community. This vision is already in place with SGU's leadership in developing and participating in the World Indigenous Higher Education Consortium. As a recent recipient of the NASA REASoN CAN award and ongoing projects with the NSF and NOAA, SGU will exemplify the culmination of these endeavors to illustrate and promote innovative partnerships with Federal Agencies, Industry Partners, mainstream academic institutions and other tribal colleges.

  20. Spin-one top partner: phenomenology

    NASA Astrophysics Data System (ADS)

    Collins, Jack H.; Jain, Bithika; Perelstein, Maxim; Lorier, Nicolas Rey-Le

    2014-08-01

    Cai, Cheng, and Terning (CCT) suggested a model in which the left-handed top quark is identified with a gaugino of an extended gauge group, and its superpartner is a spin-1 particle. We perform a phenomenological analysis of this model, with a focus on the spin-1 top partner, which we dub the "swan". We find that precision electroweak fits, together with direct searches for Z ' bosons at the LHC, place a lower bound of at least about 4.5 TeV on the swan mass. An even stronger bound, 10 TeV or above, applies in most of the parameter space, mainly due to the fact that the swan is typically predicted to be significantly heavier than the Z '. We find that the 125 GeV Higgs can be easily accommodated in this model with non-decoupling D-terms. In spite of the strong lower bound on the swan mass, we find that corrections to Higgs couplings to photons and gluons induced by swan loops are potentially observable at future Higgs factories. We also briefly discuss the prospects for discovering a swan at the proposed 100 TeV pp collider.

  1. Intimate partner aggression and women's work outcomes.

    PubMed

    LeBlanc, Manon Mireille; Barling, Julian; Turner, Nick

    2014-10-01

    Using conservation of resources theory, we examined the relationship between intimate partner aggression enacted against heterosexual women and 3 types of work-related outcomes for these women: withdrawal while at work (i.e., cognitive distraction, work neglect), withdrawal from work (i.e., partial absenteeism, intentions to quit), and performance. In Study 1, we compared withdrawal both at and from work across 3 clinically categorized groups of women (n = 50), showing that experiencing physical aggression is related to higher work neglect. We replicated and extended these findings in Study 2 using a community sample of employed women (n = 249) by considering the incremental variance explained by both physical aggression and psychological aggression on these same outcomes. Results showed that physical aggression predicted higher levels of withdrawal both at and from work, with psychological aggression predicting additional variance in partial absenteeism over and above the effects of physical aggression. Study 3 extended the model to include academic performance as an outcome in a sample of female college students (n = 122) in dating relationships. Controlling for the women's conscientiousness, psychological aggression predicted lower academic performance after accounting for the effects of physical aggression. We discuss theoretical and practical implications of these results, as well as directions for future research. PMID:25068818

  2. Partners in quality: managing your suppliers.

    PubMed

    Conway, B A

    1991-05-01

    Just expecting more from your supplier is not what partnership is about. We have had the experience where the quality improvement and partnership banner has been waved but the tone and spirit of the meeting did not encourage or support a joint quality improvement effort. Benefits will not be achieved until the wall truly begins to come apart and the relationship is built on mutual respect and trust. Data collection and open answers to questions often reveal embarrassing errors and obvious needs for improvements. As stated before, blame and finger-pointing must be replaced with a mutual commitment to asking and answering the question, "How can we improve?" As Dr. W. Edwards Deming has stated, "End the practice of awarding business on the basis of price tag. Instead, minimize total cost. Move toward a single supplier for any one item on a long-term relationship of loyalty and trust." The structured approach of a quality improvement process and the application of quality methods and techniques has proven useful in removing emotion and helping the team focus on the process rather than the people and the issues involved. Quality improvement methods are focused on achieving both customer and supplier goals--customer satisfaction, employee satisfaction, and operational efficiency and effectiveness. Our experience with Partners in Quality as well as our experience with the quality leadership process supports a recent quote in the Harvard Business Review: "Quality is not just a slogan...(it is) the most profitable way to run a business." PMID:10110237

  3. PARTNER INVOLVEMENT: NEGOTIATING THE PRESENCE OF PARTNERS IN PSYCHOSOCIAL ASSESSMENT AS CONDUCTED BY MIDWIVES AND CHILD AND FAMILY HEALTH NURSES.

    PubMed

    Rollans, Mellanie; Kohlhoff, Jane; Meade, Tanya; Kemp, Lynn; Schmied, Virginia

    2016-05-01

    Universal screening for maternal depression and assessment of psychosocial risks has been integrated into the routine perinatal care provided in many Australian hospitals, but to date, partners/fathers have been largely excluded from the process. This study explored the ways in which clinicians in health service settings include partners who attend antenatal and postnatal visits with women. Qualitative data were collected using observations (n = 54), interviews (n = 60), and discussion groups (n = 7) with midwives and child and family health nurses who conducted the appointments. Transcripts from observations, interviews, and discussion groups underwent qualitative analysis, and key themes were identified. Results showed partners to have little or no involvement in psychosocial assessment and depression screening. Thematic analysis revealed four key themes: negotiating partner exclusion, partial inclusion, women's business or a couple concern? and they know anyway. Partner involvement appeared to be challenged particularly by mandatory interpersonal violence screening, which, according to health service policy, is to be conducted confidentially. Overall, results highlighted partner involvement in perinatal depression screening and psychosocial assessment processes and identified some of the benefits such as partner disclosure, but also the challenges and complexities of inclusion of partners. Clinical implications and directions for further education and research are discussed. PMID:27111339

  4. Co-Production at the Strategic Level: Co-Designing an Integrated Care System with Lay Partners in North West London, England.

    PubMed

    Morton, Michael; Paice, Elisabeth

    2016-01-01

    In North West London, health and social care leaders decided to design a system of integrated care with the aim of improving the quality of care and supporting people to maintain independence and participation in their community. Patients and carers, known as 'lay partners,' were to be equal partners in co-production of the system. Lay partners were recruited by sending a role profile to health, social care and voluntary organisations and requesting nominations. They formed a Lay Partners Advisory Group from which pairs were allocated to system design workstreams, such as which population to focus on, financial flow, information technology and governance. A larger and more diverse Lay Partners Forum provided feedback on the emerging plans. A key outcome of this approach was the development of an integration toolkit co-designed with lay partners. Lay partners provided challenge, encouraged innovation, improved communication, and held the actions of other partners to account to ensure the vision and aims of the emerging integrated care system were met. Key lessons from the North West London experience for effective co-production include: recruiting patients and carers with experience of strategic work; commitment to the vision; willingness to challenge and to listen; strong connections within the community being served; and enough time to do the work. Including lay partners in co-design from the start, and at every level, was important. Agreeing the principles of working together, providing support and continuously recruiting lay representatives to represent their communities are keys to effective co-production. PMID:27616958

  5. Intimacy as an interpersonal process: the importance of self-disclosure, partner disclosure, and perceived partner responsiveness in interpersonal exchanges.

    PubMed

    Laurenceau, J P; Barrett, L F; Pietromonaco, P R

    1998-05-01

    H. T. Reis and P. Shaver's (1988) interpersonal process model of intimacy suggests that both self-disclosure and partner responsiveness contribute to the experience of intimacy in interactions. Two studies tested this model using an event-contingent diary methodology in which participants provided information immediately after their social interactions over 1 (Study 1) or 2 (Study 2) weeks. For each interaction, participants reported on their self-disclosures, partner disclosures, perceived partner responsiveness, and degree of intimacy experienced in the interaction. Overall, the findings strongly supported the conceptualization of intimacy as a combination of self-disclosure and partner disclosure at the level of individual interactions with partner responsiveness as a partial mediator in this process. Additionally, in Study 2, self-disclosure of emotion emerged as a more important predictor of intimacy than did self-disclosure of facts and information. PMID:9599440

  6. MPI Profiling

    SciTech Connect

    Han, D K; Jones, T R

    2005-02-11

    The Message Passing Interface (MPI) is the de facto message-passing standard for massively parallel programs. It is often the case that application performance is a crucial factor, especially for solving grand challenge problems. While there have been many studies on the scalability of applications, there have not been many focusing on the specific types of MPI calls being made and their impact on application performance. Using a profiling tool called mpiP, a large spectrum of parallel scientific applications were surveyed and their performance results analyzed.

  7. Chart Venture Partners' perspective on dual-use CBRNE technologies

    NASA Astrophysics Data System (ADS)

    Van Nice, C. S.; Gardner, P. J.

    2008-04-01

    Chart Venture Partners' (CVP) approach to investing in Chemical, Biological, Radiological, Nuclear, and Explosives (CBRNE) detection technologies can be best understood in the context of the unique partnership between the firm's two founding institutions. CVP was founded as a partnership between the Chart Group, a New York-based merchant banking and venture capital boutique, and InSitech Incorporated, a 501(c)(3) non-profit commercial partnership intermediary for the U.S. Army's Armament Research Development and Engineering Center (ARDEC) at Picatinny Arsenal in New Jersey. The partnership between Chart Group and Insitech has yielded a new investment model. Unlike most venture funds, CVP operates with a singular focus on early-stage defense and security technologies, with the important caveat that everything we invest in must also have dual-use application in large-scale commercial markets. CVP believes that early-stage CBRNE companies require five qualities to be viable investment candidates and successful start-up companies: Great Science, Strong IP Positions, Recognized Scientific Champions, Identified Dual-Use Market Pull, and "Real World" Technical Performance Data. When earlystage CBRNE companies decide to seek venture capital and pursue higher growth dual-use business models, we often find that certain issues arise that are not always fully contemplated at the outset, and that can create gaps between what the start-up companies are offering to investors and what those investors are seeking from their potential portfolio companies. These same issues can have significant positive or negative impact on shareholder value over time, depending on how they are managed. Specifically, startups should consider carefully their strategies related to business development, market positioning, government funding, and investment syndicate formation.

  8. Identification of brain-specific angiogenesis inhibitor 2 as an interaction partner of glutaminase interacting protein

    SciTech Connect

    Zencir, Sevil; Ovee, Mohiuddin; Dobson, Melanie J.; Banerjee, Monimoy; Topcu, Zeki; Mohanty, Smita

    2011-08-12

    Highlights: {yields} Brain-specific angiogenesis inhibitor 2 (BAI2) is a new partner protein for GIP. {yields} BAI2 interaction with GIP was revealed by yeast two-hybrid assay. {yields} Binding of BAI2 to GIP was characterized by NMR, CD and fluorescence. {yields} BAI2 and GIP binding was mediated through the C-terminus of BAI2. -- Abstract: The vast majority of physiological processes in living cells are mediated by protein-protein interactions often specified by particular protein sequence motifs. PDZ domains, composed of 80-100 amino acid residues, are an important class of interaction motif. Among the PDZ-containing proteins, glutaminase interacting protein (GIP), also known as Tax Interacting Protein TIP-1, is unique in being composed almost exclusively of a single PDZ domain. GIP has important roles in cellular signaling, protein scaffolding and modulation of tumor growth and interacts with a number of physiological partner proteins, including Glutaminase L, {beta}-Catenin, FAS, HTLV-1 Tax, HPV16 E6, Rhotekin and Kir 2.3. To identify the network of proteins that interact with GIP, a human fetal brain cDNA library was screened using a yeast two-hybrid assay with GIP as bait. We identified brain-specific angiogenesis inhibitor 2 (BAI2), a member of the adhesion-G protein-coupled receptors (GPCRs), as a new partner of GIP. BAI2 is expressed primarily in neurons, further expanding GIP cellular functions. The interaction between GIP and the carboxy-terminus of BAI2 was characterized using fluorescence, circular dichroism (CD) and nuclear magnetic resonance (NMR) spectroscopy assays. These biophysical analyses support the interaction identified in the yeast two-hybrid assay. This is the first study reporting BAI2 as an interaction partner of GIP.

  9. Nuclear Medicine

    MedlinePlus

    ... Parents/Teachers Resource Links for Students Glossary Nuclear Medicine What is nuclear medicine? What are radioactive tracers? ... funded researchers advancing nuclear medicine? What is nuclear medicine? Nuclear medicine is a medical specialty that uses ...

  10. Perpetration and Victimization of Intimate Partner Aggression Among Rural Mothers

    PubMed Central

    Schwab Reese, Laura M.; Harland, Karisa; Smithart, Kelsey

    2015-01-01

    Abstract Intimate partner aggression is a leading cause of injury among women of child-bearing age. Research suggests that pregnancy and the postpartum period are times of increased vulnerability to aggression. Since rural women are at an increased risk of intimate partner aggression, research is needed to examine the role of pregnancy and the presence of children on intimate partner aggression among this vulnerable population. The purpose of this study is to examine the association between young children and intimate partner aggression victimization and perpetration among a rural sample. This analysis utilized data from biologic females of child-bearing age from the Keokuk County Rural Health Study, a cohort study of over 1,000 rural families conducted from 1994 to 2011. Crude and adjusted logistic regression was used to determine the relationship between having a young child and experiencing four forms of intimate partner aggression: verbal aggression perpetration, verbal aggression victimization, physical aggression perpetration, and physical aggression victimization. Having young children was significantly associated with increased odds of perpetrating verbal aggression but not victimization of verbal aggression or perpetration and victimization of physical aggression. This significant relationship persisted after adjustment for education, employment, or location of residence but not age or marital status. The increased odds of perpetrating verbal aggression among mothers in a rural area highlight the need for interventions designed for rural parents. One method of reducing intimate partner aggression may be to incorporate intimate partner aggression prevention activities into existing child abuse intervention activities.

  11. INTIMATE PARTNER VIOLENCE AND INCIDENCE OF HYPERTENSION IN WOMEN

    PubMed Central

    Mason, SM; Wright, RJ; Hibert, EN; D, Spiegelman; Forman, JP; Rich-Edwards, JW

    2013-01-01

    Purpose Intimate partner violence, a prevalent stressor for women, may influence cardiovascular disease risk. We estimated the association between intimate partner violence and development of hypertension, an important risk factor for cardiovascular disease, using data on intimate partner violence in the Nurses’ Health Study II cohort. Methods Intimate partner violence measures included adult lifetime physical and sexual partner violence and the Women’s Experiences with Battering Scale, which ascertained women’s subjective experience of recent emotional abuse. Physician-diagnosed hypertension was self-reported on biennial questionnaires. We used Cox proportional hazards models to estimate the association between report of intimate partner violence in 2001 and incidence of hypertension from 2001 through 2007. Results Of 51,434 included respondents, 22% reported being physically hurt and 10% reported being forced into sexual activities at some point in adulthood by an intimate partner. After adjustment for confounders, physical and sexual abuse were not associated with hypertension. However, women reporting the most severe emotional abuse had a 24% increased rate of hypertension (hazard ratio=1.24; 95% confidence interval: 1.02, 1.53) when compared to women unexposed to emotional abuse. Conclusion Hypertension risk appears to be elevated in the small number of women recently exposed to severe emotional abuse. PMID:22717307

  12. Intimate partner violence injuries--Oklahoma, 2002.

    PubMed

    2005-10-21

    Intimate partner violence (IPV) is a serious public health problem in the United States and a common cause of injury. Prevalence rates of IPV vary by the surveillance methods and definitions used. National data from the 1995 National Violence Against Women Survey indicate that 22.1% of women and 7.4% of men experience IPV during their lifetimes and that 1.3% of women and 0.9% of men experience IPV annually. IPV results in an estimated 4.1 billion dollars each year in direct medical and mental health-care costs, including 159 million dollars in emergency department (ED) treatments for IPV physical assaults. IPV might constitute as much as 17% of all violence-related injuries treated in EDs. To determine the magnitude of the IPV problem in Oklahoma, including IPV-related injuries and medical service utilization, researchers analyzed injury surveillance data from ED medical records and data from the Oklahoma Women's Health Survey (OWHS). This report summarizes the findings, which indicated that, during 2002 in Oklahoma, approximately 16% of all ED visits for assaults were for IPV injuries, including 35% of assault visits among females and 3% of assault visits among males. In addition, results of the OWHS for 2001-2003 indicated that 5.9% of surveyed Oklahoma women aged 18-44 years sustained an IPV injury during the preceding year. Overall, IPV resulted in a substantial number of injuries, particularly to women, many of whom required treatment in EDs. Medical recognition and documentation of IPV are important for identification of persons in need of services. PMID:16237374

  13. Understanding intimate partner violence and its correlates

    PubMed Central

    Ramadugu, Shashikumar; Jayaram, Prasad V.; Srivastava, Kalpana; Chatterjee, Kaushik; Madhusudan, T.

    2015-01-01

    Objectives: This study assessed intimate partner violence (IPV) and alcohol use in an urban population in Pune, India. The prevalence of IPV and alcohol use was assessed along with the correlation of IPV with alcohol and other variables. Materials and Methods: The study was cross-sectional, questionnaire-based. The materials used were the hurt insult threaten scream (HITS) scale, the alcohol use disorders identification test, and a brief psychosocial questionnaire. Systematic random sampling was done on the target population. Regression analysis of various factors in relation to HITS score was done. Results: Sample size (n) was 318 individuals. Prevalence of IPV was found to be 16% and the victims were mostly women. Prevalence of alcohol use was 44%, of which 8.9% were harmful users. No female subjects consumed alcohol, but 94% were aware of their husband's alcohol consumption. No significant correlation was found between IPV and education (P = 0.220) or income of women (P = 0.250). Alcohol consumption by males was a significant risk factor for women experiencing IPV (σ = +0.524; P< 0.001). Regression analysis also revealed that increasing marital age (P = 0.019) and financial support from in-laws (P = 0.040) were significantly protective. Conclusion: IPV prevalence was less than the national average for India, but the majority of victims was women. The most common type of IPV was verbal. Alcohol use prevalence was higher than the national average, but harmful use was lower. Alcohol use is a significant risk factor for IPV. Education and income of women were not significantly protective against IPV but increased age at marriage and support from in-laws were. PMID:27212823

  14. Partnering Strategies for Childhood Agricultural Safety and Health

    PubMed Central

    Hard, David L.

    2015-01-01

    The National Institute for Occupational Safety and Health (NIOSH) has been the lead federal agency of the national Childhood Agricultural Injury Prevention Initiative (CAIPI) since the program's inception in 1996 and in this role, collaborated with numerous partners in childhood agricultural injury prevention activities. This collaboration has likely helped achieve the current reduction in childhood agricultural injury. The paper looks at existing groups with past and current childhood agricultural injury prevention activities for partnering strategies that could contribute to reducing the morbidity and mortality of childhood agricultural injuries. Based upon the review, suggestions are made for future partnering strategies to continue progress in this area. PMID:22490034

  15. PTSD and conflict behavior between veterans and their intimate partners

    PubMed Central

    Miller, Mark W.; Wolf, Erika J.; Reardon, Annemarie F.; Harrington, Kelly M.; Ryabchenko, Karen; Castillo, Diane; Freund, Rachel; Heyman, Richard

    2013-01-01

    This study examined the influence of trauma history and PTSD symptoms on the behavior of veterans and their intimate partners (287 couples; N = 574) observed during conflict discussions and coded using the Rapid Marital Interaction Coding System (Heyman, 2004). Dyadic structural equation modeling analyses showed that PTSD was associated with more frequent displays of hostility and psychological abuse and fewer expressions of acceptance and humor in both veterans and their partners. Findings provide new insight into the social and emotional deficits associated with PTSD and emphasize the importance of addressing the trauma histories and PTSD of both partners when treating veteran couples with relationship disturbance. PMID:23523947

  16. [Chronic heart failure and its consequences on the partner relationship].

    PubMed

    Sztajzel, Juan

    2015-12-01

    There are presently few data on chronic heart failure (CHF) and its consequences on the partner relationship. The aim of our study was to assess how patients with severe CHF and their female partners were affected in their relationship. First, there was a need to address the issue of sexuality with the doctor because of fear of the occurrence of a cardiac event or an implantable cardioverter defibrillator shock. Second, there was often a significant decrease in libido and erectile dysfunction associated with general depressive symptoms. Finally, the female partners in several couples developed an overprotective behavior leading to resentment and frustration in patients towards them. PMID:26790235

  17. Identification of FAM96B as a novel prelamin A binding partner

    SciTech Connect

    Xiong, Xing-Dong; Wang, Junwen; Zheng, Huiling; Jing, Xia; Liu, Zhenjie; Zhou, Zhongjun; Liu, Xinguang

    2013-10-11

    Highlights: •We screen the binding protein of prelamin A by yeast two-hybrid screen. •FAM96B colocalizes with prelamin A in HEK-293 cells. •FAM96B physically interacts with prelamin A. -- Abstract: Prelamin A accumulation causes nuclear abnormalities, impairs nuclear functions, and eventually promotes cellular senescence. However, the underlying mechanism of how prelamin A promotes cellular senescence is still poorly understood. Here we carried out a yeast two-hybrid screen using a human skeletal muscle cDNA library to search for prelamin A binding partners, and identified FAM96B as a prelamin A binding partner. The interaction of FAM96B with prelamin A was confirmed by GST pull-down and co-immunoprecipitation experiments. Furthermore, co-localization experiments by fluorescent confocal microscopy revealed that FAM96B colocalized with prelamin A in HEK-293 cells. Taken together, our data demonstrated the physical interaction between FAM96B and prelamin A, which may provide some clues to the mechanisms of prelamin A in premature aging.

  18. Urban Adolescent Girls’ Perspectives on Multiple Partners in the Context of the Sexual Double Standard and Intimate Partner Violence

    PubMed Central

    Teitelman, Anne M.; Tennille, Julie; Bohinski, Julia; Jemmott, Loretta S.; Jemmott, John B.

    2013-01-01

    This article describes the influence of abusive and non-abusive relationship dynamics on the number of sex partners among urban adolescent girls. Focus groups were conducted with 64 sexually active adolescent girls ages 14 to 17 years. General coding and content analyses identified patterns, themes, and salient beliefs. More than one third (37.5%) reported having experienced physical, intimate partner violence; 32.8% had 2 or more recent sex partners, and 37.5% had ever had a sexually transmitted infection (STI) or HIV. Although some girls in abusive relationships feared retribution if they had more than one partner, others sought additional partners for solace or as an act of resistance. Adolescent HIV/STI prevention programs need to address the influence of gender norms such as the sexual double standard as well as partner pressure and partner abuse on adolescent decision-making about safer sex, and also promote healthy relationships as integral to advancing HIV/STI risk reduction. PMID:23790274

  19. Urban adolescent girls' perspectives on multiple partners in the context of the sexual double standard and intimate partner violence.

    PubMed

    Teitelman, Anne M; Tennille, Julie; Bohinski, Julia; Jemmott, Loretta S; Jemmott, John B

    2013-01-01

    This article describes the influence of abusive and nonabusive relationship dynamics on the number of sex partners among urban adolescent girls. Focus groups were conducted with 64 sexually active adolescent girls ages 14 to 17 years. General coding and content analyses identified patterns, themes, and salient beliefs. More than one third (37.5%) reported having experienced physical, intimate partner violence; 32.8% had two or more recent sex partners, and 37.5% had ever had a sexually transmitted infection (STI) or HIV. Although some girls in abusive relationships feared retribution if they had more than one partner, others sought additional partners for solace or as an act of resistance. Adolescent HIV/STI prevention programs need to address the influence of gender norms such as the sexual double standard, as well as partner pressure and partner abuse on adolescent decision-making about safer sex, and also promote healthy relationships as integral to advancing HIV/STI risk reduction. PMID:23790274

  20. Preparing Scientists to be Community Partners

    NASA Astrophysics Data System (ADS)

    Pandya, R. E.

    2012-12-01

    Many students, especially students from historically under-represented communities, leave science majors or avoid choosing them because scientific careers do not offer enough opportunity to contribute to their communities. Citizen science, or public participation in scientific research, may address these challenges. At its most collaborative, it means inviting communities to partner in every step of the scientific process from defining the research question to applying the results to community priorities. In addition to attracting and retaining students, this level of community engagement will help diversify science, ensure the use and usability of our science, help buttress public support of science, and encourage the application of scientific results to policy. It also offers opportunities to tackle scientific questions that can't be accomplished in other way and it is demonstrably effective at helping people learn scientific concepts and methods. In order to learn how to prepare scientists for this kind of intensive community collaboration, we examined several case studies, including a project on disease and public health in Africa and the professionally evaluated experience of two summer interns in Southern Louisiana. In these and other cases, we learned that scientific expertise in a discipline has to be accompanied by a reservoir of humility and respect for other ways of knowing, the ability to work collaboratively with a broad range of disciplines and people, patience and enough career stability to allow that patience, and a willingness to adapt research to a broader set of scientific and non-scientific priorities. To help students achieve this, we found that direct instruction in participatory methods, mentoring by community members and scientists with participatory experience, in-depth training on scientific ethics and communication, explicit articulation of the goal of working with communities, and ample opportunity for personal reflection were essential

  1. Migration, Social Organization, and the Sexual Partners of Mexican Men

    PubMed Central

    Parrado, Emilio A.; Flippen, Chenoa A.

    2015-01-01

    We build on recent developments in social organization theory to examine the sexual partnering of Mexican men in a new area of immigrant destination. We elaborate on two levels of contextual influence: 1) how differences in social capital between sending and receiving communities affect partner formation and 2) how neighborhood social cohesion influences immigrants’ behavior. Data come from an original survey conducted in Durham, NC and migrant sending communities in Mexico. We show dramatic differences in sexual partnering between Mexico and the U.S. that are directly linked to lack of social networks and familial support. Neighborhood level social cohesion in part counteracts those effects. The role of social capital and neighborhoods, however, is highly gendered. The presence of women is a critical dimension of the social organization of immigrant communities and its effect extends beyond mere partner availability. PMID:26962267

  2. PARTNERING TO COLLECT IMPROVED HUMAN EXPOSURE MEASUREMENT DATA

    EPA Science Inventory

    Partnering allows complex environmental challenges to be efficiently addressed by leveraging resources and scientific expertise. The US Environmental Protection Agency's Office of Research and Development (ORD) routinely collaborates with other federal, state, and local governme...

  3. Intimate Partner Violence in the United States - 2010

    MedlinePlus

    ... Partner Violence in the United States—2010 • An estimated 16.9% of women and 8.0% of ... proportion of the unknowns that are eligible is estimated. The weighted cooperation rate was 81.3%. A ...

  4. 20 CFR 404.1088 - Retirement payment to retired partners.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... financial obligations to you (in his or her capacity as a partner) except to make the retirement payments... set out in 26 CFR 1.1402(a)-(17) and the conditions in paragraph (b) of this section are met....

  5. Partner dyspareunia--a report of six cases.

    PubMed

    Petri, Eckhard; Ashok, Kiran

    2012-01-01

    One of the rarely cited complications of the use of alloplastic materials in pelvic floor surgery is dyspareunia of the partner caused by prominence or vaginal exposure of the sling material. Even though this entity is real and an important problem, it is rarely reported in literature. We report six cases of partner dyspareunia, in which there were two incidences of partner penile injury, occurring as a complication of synthetic midurethral sling surgery. There were three tension-free vaginal tapes, two transobturator tapes and one anterior intravaginal sling in the series. Time interval between tape insertion and the presentation of complications ranged from 3 to 48 months. Vaginal exposure was seen in five of the six cases and in one patient prominence of sling material without exposure was noted. Recognizing partner dyspareunia as an important complication of the vaginal use of alloplastic prosthesis is not only important in preoperative counseling of patients but also to avoid legal implications. PMID:21800200

  6. A Systematic Review of Risk Factors for Intimate Partner Violence

    PubMed Central

    Capaldi, Deborah M.; Knoble, Naomi B.; Shortt, Joann Wu; Kim, Hyoun K.

    2012-01-01

    A systematic review of risk factors for intimate partner violence was conducted. Inclusion criteria included publication in a peer-reviewed journal, a representative community sample or a clinical sample with a control-group comparison, a response rate of at least 50%, use of a physical or sexual violence outcome measure, and control of confounding factors in the analyses. A total of 228 articles were included (170 articles with adult and 58 with adolescent samples). Organized by levels of a dynamic developmental systems perspective, risk factors included: (a) contextual characteristics of partners (demographic, neighborhood, community and school factors), (b) developmental characteristics and behaviors of the partners (e.g., family, peer, psychological/behavioral, and cognitive factors), and (c) relationship influences and interactional patterns. Comparisons to a prior review highlight developments in the field in the past 10 years. Recommendations for intervention and policy along with future directions for intimate partner violence (IPV) risk factor research are presented. PMID:22754606

  7. 20 CFR 404.1088 - Retirement payment to retired partners.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... set out in 26 CFR 1.1402(a)-(17) and the conditions in paragraph (b) of this section are met. The... partner in the DEF partnership, retired from the partnership as of December 31, 1976. The taxable year...

  8. Isovector and hidden-beauty partners of the X(3872)

    NASA Astrophysics Data System (ADS)

    Høgaasen, Hallstein; Kou, Emi; Richard, Jean-Marc; Sorba, Paul

    2014-05-01

    The isovector partners of the X(3872), recently found at BES III, Belle and CLEO-c were predicted in a simple model based on the chromomagnetic interaction among quarks. The extension to the hidden-beauty sector is discussed.

  9. The role of the sexual partner in managing erectile dysfunction.

    PubMed

    Li, Hongjun; Gao, Tiejun; Wang, Run

    2016-03-01

    Erectile dysfunction (ED) has detrimental social and psychological effects on the quality of life of affected individuals and their sexual partners. When medical intervention is introduced to treat ED, physicians, nurses, and clinical educators should consider this disorder as a shared health problem for the men with ED and their sexual partners. New therapeutics such as phosphodiesterase-5 inhibitors improve erectile function in affected men, and the ultimate goal of medical intervention for ED should be achievement of a satisfactory sex life for couples engaged sexual relationships. Sexual partners of men with ED have an important role in its management and improvement in quality of sex life; therefore, they should be involved in assessment of, diagnosis, education, counselling, and choice of therapy. This sexual- partner-engaged approach might assist treatment and rehabilitation, helping the couples affected by ED to achieve a high-quality sex life. PMID:26832165

  10. Intersection of Intimate Partner Violence and HIV in Women

    MedlinePlus

    ... in approximately 40 to 45 percent of physically violent intimate relationships and increases a woman’s risk for ... might negotiate condom use with partners while avoiding violent reactions. For example, condom requests that describe HIV ...

  11. Domestic Homicide: Neuropsychological Profiles of Murderers Who Kill Family Members and Intimate Partners.

    PubMed

    Hanlon, Robert E; Brook, Michael; Demery, Jason A; Cunningham, Mark D

    2016-01-01

    Domestic homicide is the most extreme form of domestic violence and one of the most common types of homicide. The objective was to examine differences between spontaneous domestic homicide and nondomestic homicide offenders regarding demographics, psychiatric history, crime characteristics, and neuropsychological status, utilizing neuropsychological test data from forensic examinations of 153 murderers. Using standard crime classification criteria, 33% committed spontaneous domestic homicides (SDH) and 61% committed nondomestic homicides (NDH). SDH offenders were more likely to manifest psychotic disorders, but less likely to be diagnosed with antisocial personality disorder or to have prior felony convictions. SDH offenders manifested significantly worse neuropsychological impairments than NDH offenders. The mean number of victims was lower for the SDH than the NDH group and only 14% of SDH offenders used a firearm, whereas 59% of NDH offenders used a firearm. These findings corroborate the notion that spontaneous domestic homicide may represent a discernible criminological phenotype. PMID:26292990

  12. Profile and programming needs of federal offenders with histories of intimate partner violence.

    PubMed

    Stewart, Lynn A; Power, Jenelle

    2014-10-01

    This study presents data on male perpetrators of domestic violence (DV) in the Correctional Service of Canada (CSC) using two samples: (a) a snapshot of all male offenders in CSC who had been assessed for DV (n = 15,166) and (b) a cumulative sample of male offenders in CSC from 2002-2010 who had been assessed as moderate or high risk for further DV (n = 4,261) DV offenders were compared to a cohort sample of non-DV offenders (n = 4,261). Analyses were disaggregated for Aboriginal and non-Aboriginal offenders. Results indicated that 40% of the federal male population had a suspected history of DV and were therefore screened in for in-depth DV risk assessment. Of these, 45% were assessed as moderate or high risk for future DV. DV offenders had higher risk and criminogenic need ratings, more learning disabilities, more mental health problems, and more extensive criminal histories than those without DV histories. Aboriginal DV offenders had high levels of alcohol dependence, suggesting a need for substance abuse treatment as part of DV programming. Most federal offenders with DV histories would be described as belonging to the Antisocial/Generalized Aggressive typology and, therefore, adhering to the Risk-Need-Responsivity principles of the effective correctional literature, cognitive-behavioral treatment that focuses on teaching skills of self-management, and changing attitudes supporting relationship violence would be recommended. PMID:24664249

  13. Partner Services as Targeted HIV Screening—Changing the Paradigm

    PubMed Central

    Stephens, Sally C.; Moss, Nicholas; Scheer, Susan; Parisi, Maree Kay; Philip, Susan S.

    2014-01-01

    Objectives The San Francisco Department of Public Health (SFDPH) has the goal of offering HIV partner services (PS) to all individuals newly diagnosed with HIV in San Francisco. However, measuring the potential impact of these services is challenging. Building on an existing syphilis partner notification program, we developed a framework for expanding and monitoring HIV PS in San Francisco. Methods We identified process and outcome measures to evaluate HIV PS in San Francisco, including the number of index patients interviewed, the proportion of named partners who had previously diagnosed HIV infection, the proportion of HIV-uninfected partners who tested through HIV PS, and the positivity rate among the partners tested. Results were recorded in a locally developed electronic surveillance and case-management system at SFDPH. Results We examined HIV PS data from 2005–2011. In 2011, 426 new HIV diagnoses were reported, and 178 were assigned for HIV PS; of these, 124 (69.7%) patients were successfully interviewed, naming a total of 109 sex partners. Of the named partners, 34 (31.2%) had been previously diagnosed with HIV. Among the remaining named partners not known to be HIV infected, 31 (32.3%) were tested, for a positivity of 22.6% (n=7). The proportion of HIV that was newly diagnosed by a provider who participated in the citywide HIV PS program increased from 15.4% in 2005 to 69.5% in 2011. Conclusions As HIV PS expand, locally relevant outcome measures are increasingly important. Using these criteria, HIV PS as a targeted screening activity resulted in the identification of newly diagnosed HIV cases. PMID:24385649

  14. The evolution of monogamy in response to partner scarcity

    PubMed Central

    Schacht, Ryan; Bell, Adrian V.

    2016-01-01

    The evolution of monogamy and paternal care in humans is often argued to have resulted from the needs of our expensive offspring. Recent research challenges this claim, however, contending that promiscuous male competitors and the risk of cuckoldry limit the scope for the evolution of male investment. So how did monogamy first evolve? Links between mating strategies and partner availability may offer resolution. While studies of sex roles commonly assume that optimal mating rates for males are higher, fitness payoffs to monogamy and the maintenance of a single partner can be greater when partners are rare. Thus, partner availability is increasingly recognized as a key variable structuring mating behavior. To apply these recent insights to human evolution, we model three male strategies – multiple mating, mate guarding and paternal care – in response to partner availability. Under assumed ancestral human conditions, we find that male mate guarding, rather than paternal care, drives the evolution of monogamy, as it secures a partner and ensures paternity certainty in the face of more promiscuous competitors. Accordingly, we argue that while paternal investment may be common across human societies, current patterns should not be confused with the reason pairing first evolved. PMID:27600189

  15. The Neurobiology of Sexual Partner Preferences in Rams

    PubMed Central

    Roselli, Charles E.; Stormshak, Fred

    2009-01-01

    The question of what causes a male animal to seek out and choose a female as opposed to another male mating partner is unresolved and remains an issue of considerable debate. The most developed biologic theory is the perinatal organizational hypothesis, which states that perinatal hormone exposure mediates sexual differentiation of the brain. Numerous animal experiments have assessed the contribution of perinatal testosterone and/or estradiol exposure to the development of a male-typical mate preference, but almost all have used hormonally manipulated animals. In contrast, variations in sexual partner preferences occur spontaneously in domestic rams, with as many as 8% of the population exhibiting a preference for same-sex mating partners (male-oriented rams). Thus, the domestic ram is an excellent experimental model to study possible links between fetal neuroendocrine programming of neural mechanisms and adult sexual partner preferences. In this review, we present an overview of sexual differentiation in relation to sexual partner preferences. We then summarize results that test the relevance of the organizational hypothesis to expression of same-sex sexual partner preferences in rams. Finally, we demonstrate that the sexual differentiation of brain and behavior in sheep do not depend critically on aromatization of testosterone to estradiol. PMID:19446078

  16. The evolution of monogamy in response to partner scarcity.

    PubMed

    Schacht, Ryan; Bell, Adrian V

    2016-01-01

    The evolution of monogamy and paternal care in humans is often argued to have resulted from the needs of our expensive offspring. Recent research challenges this claim, however, contending that promiscuous male competitors and the risk of cuckoldry limit the scope for the evolution of male investment. So how did monogamy first evolve? Links between mating strategies and partner availability may offer resolution. While studies of sex roles commonly assume that optimal mating rates for males are higher, fitness payoffs to monogamy and the maintenance of a single partner can be greater when partners are rare. Thus, partner availability is increasingly recognized as a key variable structuring mating behavior. To apply these recent insights to human evolution, we model three male strategies - multiple mating, mate guarding and paternal care - in response to partner availability. Under assumed ancestral human conditions, we find that male mate guarding, rather than paternal care, drives the evolution of monogamy, as it secures a partner and ensures paternity certainty in the face of more promiscuous competitors. Accordingly, we argue that while paternal investment may be common across human societies, current patterns should not be confused with the reason pairing first evolved. PMID:27600189

  17. Juvenile play conditions sexual partner preference in adult female rats.

    PubMed

    Paredes-Ramos, Pedro; Miquel, Marta; Manzo, Jorge; Coria-Avila, Genaro A

    2011-10-24

    Rats can display a conditioned partner preference for individuals that bear an odor previously associated with sexual reward. Herein we tested the possibility that odors associated with the reward induced by social play in prepubescent rats would induce a conditioned partner preference in adulthood. Two groups of 31-day-old, single-housed female rats were formed, and were given daily 30-min periods of social play with scented females. In one group, almond scent was paired with juvenile play during conditioning trials, whereas lemon scent functioned as a novel odor in the final test. The counterbalanced group received the opposite association. At age 42, females were tested for play partner preference with two males, one almond-scented and one lemon-scented. In both groups females displayed a play partner preference only for males scented with the paired odor. They were ovariectomized, hormone-primed, and at age 55 were tested for sexual partner preference with two scented stud males. Females displayed a sexual preference towards males scented with the paired odor as observed with more visits, solicitations, hops and darts, intromissions and ejaculations. These results indicate that olfactory stimuli paired with juvenile play affects later partner choice for play as well as for sex in female rats. PMID:21777597

  18. Older Romantic Partners and Depressive Symptoms During Adolescence

    PubMed Central

    Halpern, Carolyn Tucker

    2010-01-01

    Although developmental theory predicts that adolescent romantic relationships have important benefits, empirical evidence suggests that they may also carry substantial psychosocial risk. This study uses data from 4,948 respondents (50% female) in Wave I and Wave II of the National Longitudinal Study of Adolescent Health to examine the association between involvement with an older romantic partner and depressive symptoms during adolescence. Ordinary least squares regression models compared Wave II depressive symptoms among respondents with older partners (defined as an age difference of 2 or more years) to respondents with same-age or younger partners, controlling for baseline depressive symptoms and sociodemographic characteristics. Ten percent of females and two percent of males reported having an older romantic partner at Wave II. Among females only, involvement with an older romantic partner was associated with a modest but significant increase in depressive symptoms between waves. This association was largely mediated by increases in substance use. Findings suggest that involvement with an older male partner during adolescence may increase the risk of poor emotional outcomes among females. PMID:20424899

  19. Venues for Meeting Sex Partners and Partner HIV Risk Characteristics: HIV Prevention Trials Network (HPTN064) Women's HIV Seroincidence Study (ISIS).

    PubMed

    Roman Isler, M; Golin, C; Wang, J; Hughes, J; Justman, J; Haley, D; Kuo, I; Adimora, A; Chege, W; Hodder, S

    2016-06-01

    Identifying venues where women meet sexual partners, particular partners who increase women's risk of acquiring HIV, could inform prevention efforts. We categorized venues where women enrolled in HPTN 064 reported meeting their last three sex partners as: (1) Formal, (2) Public, (3) Private, and (4) Virtual spaces. We used multinomial logistic regression to assess the association between these venues and women's individual characteristics and reports of their partners' HIV risk characteristics. The 2099 women reported meeting 3991 partners, 51 % at Public, 30 % Private, 17 % Formal and 3 % at Virtual venues. Women meeting partners at Formal venues reported more education and condom use than women meeting partners at other venues. Fewer partners met through Formal venues had "high" risk characteristics for HIV than through other venues and hence may pose less risk of HIV transmission. HIV prevention interventions can help women choose partners with fewer risk characteristics across all venue types. PMID:25863466

  20. Childhood Bullying Involvement and Exposure to Intimate Partner Violence

    PubMed Central

    Bauer, Nerissa S.; Herrenkohl, Todd I.; Lozano, Paula; Rivara, Frederick P.; Hill, Karl G.; Hawkins, J. David

    2008-01-01

    OBJECTIVE Our objectives with this study were to describe the prevalence of bullying involvement (ie, bullying and victimization) among children from a multigenerational study and to examine the relationship of these childhood behaviors and exposure to intimate partner violence. METHODS A community-based cohort of 112 children (aged 6 to 13 years) was asked to self-report on physical, verbal, and relational types of bullying and victimization experienced in the past year. Parents reported on their child’s externalizing and internalizing behaviors during the previous 6 months using items from Achenbach’s Child Behavior Checklist. The frequency of parental experiences of intimate partner violence perpetration and victimization at 2 time points during the preceding 5 years was measured using Conflict Tactics Scale items. The association of intimate partner violence and parent-reported child behavioral problems was examined, followed by exposure to intimate partner violence and child-reported bullying or victimization. Parental risk factors (eg, race/ethnicity, education, problem drinking) that predispose to intimate partner violence were controlled for using propensity score statistical modeling. RESULTS Eighty-two (73.2%) children reported being victimized by peers, and 38 (33.9%) children reported bullying behaviors in the past year. More reports came from girls than from boys (55% for victimization and 61% for bullying). Almost all (97%) child bullies were also victims themselves. Intimate partner violence was reported by parent respondents in 53 (50.5%) households at any or both of the 2 time points. Exposure to intimate partner violence was not associated with child-reported relational bullying behaviors or victimization by peers, However, intimate partner violence–exposed children were at increased risk for problematic levels of externalizing behavior/physical aggression and internalizing behaviors. CONCLUSIONS In our sample, children who were 6 to 13

  1. Social desirability and partner agreement of men's reporting of intimate partner violence in substance abuse treatment settings.

    PubMed

    Freeman, Andrew J; Schumacher, Julie A; Coffey, Scott F

    2015-02-01

    Estimates indicate that intimate partner violence (IPV) occurs in approximately 30% of relationships and up to 85% of the relationships of men in substance abuse treatment. However, partners consistently display poor agreement in reporting the presence of IPV. Social desirability is frequently offered as the primary reason for under-reporting of IPV by perpetrators. The goal of the current study was to explicitly test the social desirability hypothesis using both partners' reports of negotiation, psychological aggression, physical aggression, sexual aggression, and injuries in a substance abuse treatment sample. A total of 54 males and their female partners were recruited from a residential adult substance use treatment facility. Consistent with prior literature, partners displayed poor agreement about the presence of different types of IPV. The male partner's social desirability was not associated with his reporting of male-to-female physical aggression, psychological aggression, or injuries. Men who engaged in higher levels of self-deceptive enhancement and lower levels of impression management were more likely to under-report male-to-female sexual coercion. Overall, the findings question the generalized importance of social desirability in IPV reporting in substance abuse treatment populations. PMID:24923888

  2. Coping Skills Training and 12-Step Facilitation for Women Whose Partner Has Alcoholism: Effects on Depression, the Partner's Drinking, and Partner Physical Violence

    ERIC Educational Resources Information Center

    Rychtarik, Robert G.; McGillicuddy, Neil B.

    2005-01-01

    Women (N = 171), distressed from their partners' untreated alcoholism, received either coping skills training (CST), 12-step facilitation (TSF), or delayed treatment (DTC). CST and TSF resulted in lower depression levels than DTC but did not differ from one another. Skill acquisition mediated the treatment effects of CST; Al-Anon attendance did…

  3. Heteronormativity and Sexual Partnering Among Bisexual Latino Men

    PubMed Central

    Garcia, Jonathan; Wilson, Patrick A.; Parker, Richard G.; Severson, Nicolette

    2015-01-01

    Our analyses address the question of how bisexual Latino men organize their sexual partnerships. Heteronormativity can be understood as the set of social norms and normative structures that guide sexual partnering among men and women. We provide descriptive statistics to describe bisexual Latino men’s sexual partnerships. Logistic and linear regression modeling were used to explore bivariate and multivariate relationships. Of our total sample (N = 142), 41.6% had unprotected vaginal intercourse 2 months prior to the interview; 21.8 % had unprotected anal intercourse with female partners; 37.5 % had unprotected insertive anal intercourse with male partners; and 22.5 % had unprotected receptive anal intercourse with male partners. In our multivariate model, machismo was directly associated with meeting female partners through formal spaces (workplace, school, and/or church), but inversely associated with meeting male partners in formal spaces. Machismo was positively associated with meeting male sex partners through social networks (i.e., friendship and kinship networks). The more comfortable men were with homosexuality the less likely they were to meet men online and the more likely they were to meet men through social networks of friends and kinship. Interventions to reduce sexually transmitted diseases that target bisexual behavior as an epidemiological “bridge” of transmission from homosexual to heterosexual networks might very well benefit from a more complex understanding of how Latino bisexuality is patterned. Thus, this exploratory analysis might lead to a rethinking of how to address risk and vulnerability among Latino bisexual men and their sexual networks. PMID:25128415

  4. Barrier-to-Autointegration Factor Proteome Reveals Chromatin-Regulatory Partners

    PubMed Central

    Montes de Oca, Rocío; Shoemaker, Christopher J.; Gucek, Marjan; Cole, Robert N.; Wilson, Katherine L.

    2009-01-01

    Nuclear lamin filaments and associated proteins form a nucleoskeletal (“lamina”) network required for transcription, replication, chromatin organization and epigenetic regulation in metazoans. Lamina defects cause human disease (“laminopathies”) and are linked to aging. Barrier-to-autointegration factor (BAF) is a mobile and essential component of the nuclear lamina that binds directly to histones, lamins and LEM-domain proteins, including the inner nuclear membrane protein emerin, and has roles in chromatin structure, mitosis and gene regulation. To understand BAF's mechanisms of action, BAF associated proteins were affinity-purified from HeLa cell nuclear lysates using BAF-conjugated beads, and identified by tandem mass spectrometry or independently identified and quantified using the iTRAQ method. We recovered A- and B-type lamins and core histones, all known to bind BAF directly, plus four human transcription factors (Requiem, NonO, p15, LEDGF), disease-linked proteins (e.g., Huntingtin, Treacle) and several proteins and enzymes that regulate chromatin. Association with endogenous BAF was independently validated by co-immunoprecipitation from HeLa cells for seven candidates including Requiem, poly(ADP-ribose) polymerase 1 (PARP1), retinoblastoma binding protein 4 (RBBP4), damage-specific DNA binding protein 1 (DDB1) and DDB2. Interestingly, endogenous BAF and emerin each associated with DDB2 and CUL4A in a UV- and time-dependent manner, suggesting BAF and emerin have dynamic roles in genome integrity and might help couple DNA damage responses to the nuclear lamina network. We conclude this proteome is a rich source of candidate partners for BAF and potentially also A- and B-type lamins, which may reveal how chromatin regulation and genome integrity are linked to nuclear structure. PMID:19759913

  5. Nuclear power and nuclear weapons

    SciTech Connect

    Vaughen, V.C.A.

    1983-01-01

    The proliferation of nuclear weapons and the expanded use of nuclear energy for the production of electricity and other peaceful uses are compared. The difference in technologies associated with nuclear weapons and nuclear power plants are described.

  6. Tissue specificity in the nuclear envelope supports its functional complexity

    PubMed Central

    de las Heras, Jose I; Meinke, Peter; Batrakou, Dzmitry G; Srsen, Vlastimil; Zuleger, Nikolaj; Kerr, Alastair RW; Schirmer, Eric C

    2013-01-01

    Nuclear envelope links to inherited disease gave the conundrum of how mutations in near-ubiquitous proteins can yield many distinct pathologies, each focused in different tissues. One conundrum-resolving hypothesis is that tissue-specific partner proteins mediate these pathologies. Such partner proteins may have now been identified with recent proteome studies determining nuclear envelope composition in different tissues. These studies revealed that the majority of the total nuclear envelope proteins are tissue restricted in their expression. Moreover, functions have been found for a number these tissue-restricted nuclear envelope proteins that fit with mechanisms proposed to explain how the nuclear envelope could mediate disease, including defects in mechanical stability, cell cycle regulation, signaling, genome organization, gene expression, nucleocytoplasmic transport, and differentiation. The wide range of functions to which these proteins contribute is consistent with not only their involvement in tissue-specific nuclear envelope disease pathologies, but also tissue evolution. PMID:24213376

  7. 26 CFR 301.6231(a)(7)-1 - Designation or selection of tax matters partner.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...) Identifies the partnership, the partner filing the statement, and the successor tax matters partner by name... statement. (e) Designation by general partners with majority interest. The partnership may designate a tax... (d), (e), or (f) of this section shall supersede all prior designations of a tax matters partner...

  8. 20 CFR 662.200 - Who are the required One-Stop partners?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Who are the required One-Stop partners? 662... DESCRIPTION OF THE ONE-STOP SYSTEM UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT One-Stop Partners and the Responsibilities of Partners § 662.200 Who are the required One-Stop partners? (a) WIA section 121(b)(1)...

  9. 24 CFR 943.150 - What procurement standards apply to a PHA's joint venture partner?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... a PHA's joint venture partner? 943.150 Section 943.150 Housing and Urban Development Regulations...'s joint venture partner? (a) General. A joint venture partner is not a grantee or subgrantee and... administration. (b) Exception. If the joint venture partner is a subsidiary, affiliate, or identity of...

  10. 24 CFR 943.150 - What procurement standards apply to a PHA's joint venture partner?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... a PHA's joint venture partner? 943.150 Section 943.150 Housing and Urban Development REGULATIONS...'s joint venture partner? (a) General. A joint venture partner is not a grantee or subgrantee and... administration. (b) Exception. If the joint venture partner is a subsidiary, affiliate, or identity of...

  11. 26 CFR 1.701-1 - Partners, not partnership, subject to tax.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 8 2010-04-01 2010-04-01 false Partners, not partnership, subject to tax. 1.701...) INCOME TAX (CONTINUED) INCOME TAXES Partners and Partnerships § 1.701-1 Partners, not partnership, subject to tax. Partners are liable for income tax only in their separate capacities. Partnerships as...

  12. 26 CFR 1.701-1 - Partners, not partnership, subject to tax.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 8 2011-04-01 2011-04-01 false Partners, not partnership, subject to tax. 1.701...) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Partners and Partnerships § 1.701-1 Partners, not partnership, subject to tax. Partners are liable for income tax only in their separate...

  13. 26 CFR 1.707-1 - Transactions between partner and partnership.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 8 2010-04-01 2010-04-01 false Transactions between partner and partnership. 1.707-1 Section 1.707-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Partners and Partnerships § 1.707-1 Transactions between partner and partnership. (a) Partner not acting...

  14. Common mental disorders and intimate partner violence in pregnancy

    PubMed Central

    Ludermir, Ana Bernarda; Valongueiro, Sandra; de Araújo, Thália Velho Barreto

    2014-01-01

    OBJECTIVE To investigate the association between common mental disorders and intimate partner violence during pregnancy. METHODS A cross sectional study was carried out with 1,120 pregnant women aged 18-49 years old, who were registered in the Family Health Program in the city of Recife, Northeastern Brazil, between 2005 and 2006. Common mental disorders were assessed using the Self-Reporting Questionnaire (SRQ-20). Intimate partner violence was defined as psychologically, physically and sexually abusive acts committed against women by their partners. Crude and adjusted odds ratios were estimated for the association studied utilizing logistic regression analysis. RESULTS The most common form of partner violence was psychological. The prevalence of common mental disorders was 71.0% among women who reported all form of violence in pregnancy and 33.8% among those who did not report intimate partner violence. Common mental disorders were associated with psychological violence (OR 2.49, 95%CI 1.8;3.5), even without physical or sexual violence. When psychological violence was combined with physical or sexual violence, the risk of common mental disorders was even higher (OR 3.45; 95%CI 2.3;5.2). CONCLUSIONS Being assaulted by someone with whom you are emotionally involved can trigger feelings of helplessness, low self-esteem and depression. The pregnancy probably increased women`s vulnerability to common mental disorders PMID:24789634

  15. Intimate partner violence and belief systems in Liberia.

    PubMed

    Allen, Mary; Devitt, Catherine

    2012-11-01

    Intimate partner violence is endemic in parts of the African continent. A small scale survey (n = 229) was conducted in 2009 in Northern Liberia, West Africa, to determine the prevalence and nature of intimate partner violence, and the cultural beliefs and gender norms that underpin respondent experiences and views towards intimate partner violence. Results show widespread experience of intimate partner violence among the respondent group, including physical abuse, sexual and verbal, and economic abuse. Acceptance of the situation was identified by most respondents as a way of responding to violence, and arises from the lack of financial and legal supports for women within the community. Despite the range of abuses experienced, beliefs about the power position of men in Liberian society provide evidence to reflect the predominance of certain cultural beliefs in framing respondents' perceptions of gender relations. The article concludes with a discussion on the possible impact of Liberia's recent conflict in contributing to the perpetuation and normalization of intimate partner violence. Further large scale research in this area is required. PMID:22610827

  16. [Chronic disease impact on partners. An explorative study].

    PubMed

    Pacini, G; Sarmiento, I

    2008-01-01

    In the last years there has been a growing interest of researchers for themes dealing with chronic illness and issues related to that condition. Several authors have studied the difficulties caregivers have to cope with, especially when the patient's partner has this role. That condition would have both physical and psychological consequences, but its real effects seem to depend on a complex set of interacting elements. On the basis of these researches, in the current study we aimed to explore the influence of adult attachment and marital satisfaction on the impact that chronic illness can have on patient's partner and on his/her health-related quality of life. The sample is composed of 40 chronic renal failure patients' partner-caregivers. Each caregiver filled in a battery of tests for finding out the characteristics of adult attachment and marital satisfaction, health-related quality of life and the association between these variables and the impact of chronic illness on partners. Descriptive statistics, correlations and one-sample t test analysis have been performed. Results show a significant correlation between attachment style and caregiving burden; there are no gender differences in disease impact on caregiver. Moreover caregivers seem to have a worse quality of life in comparison to general population. Understanding caregiving can lead, at a future time, to planning specific interventions for both patients and partners, using a global and integrated approach that respects individuals and couples in their biologic, psychological and relational dimensions. PMID:19288778

  17. Intimate partner relationship distress in the DSM-5.

    PubMed

    Foran, Heather M; Whisman, Mark A; Beach, Steven R H

    2015-03-01

    Over the past 40 years, a large body of literature has documented intimate partner relationship distress as a primary reason for seeking mental health services as well as an integral factor in the prognosis and treatment of a range of mental and physical health conditions. In recognition of its relevance to clinical care, the description of intimate partner relationship distress has been expanded in the DSM-5. Nonetheless, this is irrelevant if the DSM-5 code for intimate partner relationship distress is not reliably used in clinical practice and research settings. Thus, with the goal of dissemination in mind, the purpose of this paper was to provide clinicians and researchers with specific guidelines on how to reliably assess intimate partner relationship distress and how this information can be used to inform treatment planning. In addition to the implications for direct clinical care, we discuss the importance of reliable assessment and documentation of intimate partner relationship distress for future progress in epidemiology, etiology, and public health research. PMID:25582661

  18. Men's perceptions and attitudes toward the partner with premenstrual syndrome.

    PubMed

    Reberte, Luciana Magnoni; de Andrade, José Henrique Cogo; Hoga, Luiza Akiko Komura; Rudge, Trudy; Rodolpho, Juliana Reale Caçapava

    2014-03-01

    This study focused on the young adult men's perceptions and behavior toward their women partners who they acknowledged as experiencing the effects of premenstrual syndrome (PMS). A qualitative study was conducted, framed by social constructivism, where individual interviews with 20 young Brazilian men aged 21 to 29 years were analyzed thematically. Four descriptive categories to express the men's experiences: (a) men's observations on partner's behavior changes, (b) early in the relationship: apprehension and confusion, (c) knowledge about PMS led men to better understanding about changes, and (d) need for support from a health care provider and medication. The men's perceptions and behavior toward their partners were strongly influenced by biomedical conceptions of PMS. Participants believed that their partners' emotions and behaviors were determined by PMS during some days of the month, consequently PMS had affected the couple's relationship. Another consequence of such medicalization was that women's complaints about PMS were rendered invisible except when viewed as a serious medical problem requiring cure, rather than a part of women's cyclical patterns. It is the case that the systematic description of men's perceptions about their partner's PMS provides an approach to this topic in educational and health care activities, with the potential to improve gender relations. PMID:23884789

  19. Condom use among Hispanic men with secondary female sexual partners.

    PubMed Central

    Marin, B V; Gomez, C A; Tschann, J M

    1993-01-01

    Greater understanding of psychosocial predictors of the use of condoms among Hispanics is needed in prevention efforts related to the human immunodeficiency virus and sexually transmitted disease epidemics among Hispanics in the United States. A telephone survey was carried out in nine States that have large populations of Hispanics, using a stratified clustered random digit dialing sampling strategy. The survey yielded interviews with 968 Hispanic men ages 18-49 years. Of them, 361 (37.8 percent) reported at least one secondary female sexual partner in the 12 months prior to the interview. Predictors were identified of condom use by those men with their secondary sex partners. Key predictors of the subjects' condom use with secondary partners included carrying condoms; self-efficacy, or a measure of the subject's perceived ability to use condoms under difficult circumstances; positive attitude toward condom use; having friends who used condoms; and lack of symptoms of depression in the week before the interview (R2 = 0.35). Significant predictors of condom carrying were being comfortable in sexual situations, positive attitude toward condom use, and self-efficacy to use condoms. Less acculturated men had more positive attitudes toward condom use and carried them more than did more acculturated men. The researchers found encouraging levels of condom use with secondary sexual partners among Hispanic men with multiple partners.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:8265759

  20. Partners of people on ART - a New Evaluation of the Risks (The PARTNER study): design and methods

    PubMed Central

    2012-01-01

    Background It is known that being on antiretroviral therapy reduces the risk of HIV transmission through sex. However it remains unknown what the absolute level of risk of transmission is in a person on ART with most recent measured HIV plasma viral load<50 c/mL in the absence of condom use. There are no data on risk of transmission for anal sex in MSM when the index partner is on ART. Methods/Design The PARTNER study is an international, observational multi-centre study, taking place from 2010 to 2014 in which HIV serodifferent partnerships who at enrolment reported recently having had condom-less vaginal or anal sexual intercourse are followed over time, with 46 monthly reporting of transmission risk behaviour through a confidential self completed risk behaviour questionnaire and with 46 monthly HIV testing for the HIV negative partner. The objective is to study (i) the risk of HIV transmission to partners, in particular in partnerships that continue not to use condoms consistently and the HIV-positive partner is on therapy with a viral load<50 copies/mL and (ii) why some partnerships do not use condoms, to describe the proportion who begin to adopt consistent condom use, and factors associated with this. For any negative partner who becomes infected phylogenetic analysis will be used following anonymisation of the samples to assess if transmission had been from the HIV infected partner. Discussion This observational study will provide missing information on the absolute risk of HIV transmission for both vaginal and anal sex when the index case is on ART with a VL<50 copies/mL in the absence of condom use. PMID:22520171

  1. Profiling and Racial Profiling: An Interactive Exercise

    ERIC Educational Resources Information Center

    Semple, Philip

    2013-01-01

    Racial Profiling has been recognized as a serious problem that affects many segments of our society and is especially notable in law enforcement. Governments and police services have pronounced that racial profiling is not acceptable and will not be tolerated. They have gone to great lengths in trying to eradicate racial profiling through…

  2. Internet Sex Ads for MSM and Partner Selection Criteria: The Potency of Race/Ethnicity Online

    PubMed Central

    Paul, Jay P.; Ayala, George; Choi, Kyung-Hee

    2009-01-01

    The explosive growth in Internet use by MSM to find sexual partners has been noted in the research literature. However, little attention has been given to the impact of participating in this online sexual marketplace for MSM of color, despite race/ethnicity as a frequently used selection criterion in personal ads or profiles. Six focus group discussions [n=50], and 35 in-depth qualitative interviews were conducted with African American, Latino, Asian and Pacific Islander MSM in Los Angeles, which included discussion of their use of Internet sites to meet/interact with other MSM. Men reported race/ethnicity as a pervasive and powerful factor in facilitating or derailing Internet-mediated sexual encounters. The racialized interactions that MSM of color reported ranged from simple expressions of race-based preferences to blatantly discriminatory/hostile interactions and often demeaning race-based sexual objectification. Experiences of rejection and a perceived hierarchy of value in the sexual market based on race had definite costs for these MSM using these online sites. Furthermore, the private and solitary nature of seeking partners online meant that there was little to buffer the corrosive aspects of those negative experiences. These online dynamics have implications for the power balance in Internet-mediated sexual liaisons, including sexual decision-making and sexual risk. PMID:21322176

  3. Syphilis Profiles, 2012

    MedlinePlus

    ... STD on Facebook Data & Statistics Sexually Transmitted Diseases Syphilis Profiles, 2012 Recommend on Facebook Tweet Share Compartir ... Profiles The following profiles provide an overview of syphilis morbidity in each of the 50 states, the ...

  4. COMPENDEX Profiling Guide.

    ERIC Educational Resources Information Center

    Standera, Oldrich

    This manual provides instructions for completing the COMPENDEX (Computerized Engineering Index) Profile Submission Form used to prepare Current Information Selection (CIS) profiles. An annotated bibliography lists nine items useful in searching for proper profile words. (AB)

  5. Nuclear rights - nuclear wrongs

    SciTech Connect

    Paul, E.F.; Miller, F.D.; Paul, J.; Ahrens, J.

    1986-01-01

    This book contains 11 selections. The titles are: Three Ways to Kill Innocent Bystanders: Some Conundrums Concerning the Morality of War; The International Defense of Liberty; Two Concepts of Deterrence; Nuclear Deterrence and Arms Control; Ethical Issues for the 1980s; The Moral Status of Nuclear Deterrent Threats; Optimal Deterrence; Morality and Paradoxical Deterrence; Immoral Risks: A Deontological Critique of Nuclear Deterrence; No War Without Dictatorship, No Peace Without Democracy: Foreign Policy as Domestic Politics; Marxism-Leninism and its Strategic Implications for the United States; Tocqueveille War.

  6. The role of alcohol use in intimate partner femicide.

    PubMed

    Sharps, P W; Campbell, J; Campbell, D; Gary, F; Webster, D

    2001-01-01

    The purpose of this study was to examine alcohol use by victims and perpetrators as a risk factor for intimate partner violence and femicide. A case control design was used to describe alcohol use among Femicide/Attempted Femicide victims (n = 380), Abused Controls (n = 384) and Non-Abused Controls (n = 376), and their intimate partners. Telephone interviews of proxies (family members or friends) of femicide victims and actual survivors of attempted femicide were conducted in 10 cities. The purpose of the interviews was to gather information about relationship violence and alcohol use by femicide victims, attempted femicide survivors, and their perpetrators. Telephone interviews of controls, recruited from the same cities by random digit dialing, were also conducted. Perpetrator problem drinking was associated with an eight fold increase in partner abuse (e beta = 8.24, p < .0001) and a two fold increased risk of femicide/attempted femicide (e beta = 2.39, p = .001), controlling for demographic differences. PMID:11444155

  7. Commercial Building Partners Catalyze High Performance Buildings Across the Nation

    SciTech Connect

    Baechler, Michael C.; Dillon, Heather E.; Bartlett, Rosemarie

    2012-08-01

    In 2008 the US Department of Energy (DOE) launched the Commercial Buildings Partnership (CBP) project to accelerate market adoption of commercially available energy saving technologies into the design process for new and upgraded commercial buildings. The CBP represents a unique collaboration between industry leaders and DOE to develop high performance buildings as a model for future construction and renovation. CBP was implemented in two stages. This paper focuses on lessons learned at Pacific Northwest National Laboratory (PNNL) in the first stage and discusses some partner insights from the second stage. In the first stage, PNNL and the National Renewable Energy Laboratory recruited CBP partners that own large portfolios of buildings. The labs provide assistance to the partners' design teams and make a business case for energy investments.

  8. Themes of relational uncertainty and interference from partners in depression.

    PubMed

    Knobloch, Leanne K; Delaney, Amy L

    2012-01-01

    This article draws on the relational turbulence model to illuminate the dynamics of depression in romantic relationships using a thematic analysis of online discourse. Three content areas of relational uncertainty were apparent: (a) depression uncertainty (questions about physical harm, source of depression, and understanding), (b) self and partner uncertainty (questions about helplessness and identity), and (c) relationship uncertainty (questions about physical intimacy, relationship satisfaction, and the future of the relationship). Three content areas of interference from partners also emerged: (a) daily routines (disruptions to household tasks; finances, work, and school; children and parenting; and family and social life), (b) personal well-being (disruptions to health and safety as well as treatment), and (c) the relationship (disruptions to sexual activity, emotional intimacy, and openness). Relational uncertainty and interference from partners coincided in people's experiences in seven ways. The article concludes by discussing the conceptual, empirical, and pragmatic implications of the findings. PMID:22260385

  9. College students' perceptions of intimate partner cyber harassment.

    PubMed

    Melander, Lisa A

    2010-06-01

    Little is known about cyber harassment in general, and in order to understand more about online harassment among intimate partners, it is important to examine people's perceptions of this new form of aggression. Using Johnson's typology of relationship violence as a guiding framework, the role of technology in partner violence was explored using data from five focus group interviews. Six themes emerged from the analyses, four of which revealed that this partner violence typology accounted for the aggressive use of technology in dating relationships. The remaining themes centered on the ways in which online harassment differs from offline violence. These findings have important theoretical implications and may inform future prevention and intervention efforts. PMID:20557245

  10. Understanding intimate partner violence against women in the rural South.

    PubMed

    Shuman, Robert D; McCauley, Jeanne; Waltermaurer, Eve; Roche, W Patrick; Hollis, Helen; Gibbons, Anne Kilgannon; Dever, Alan; Jones, Solita; McNutt, Louise-Anne

    2008-01-01

    Most U.S. intimate partner violence (IPV) research to date has been limited to women residing in urban areas, with the small body of research focusing on rural populations being primarily qualitative. In this case-control study of Southern rural women, while many factors are consistent with those found in urban settings, unlike findings elsewhere, IPV risk appears to increase with age, and race showed no increased risk. Furthermore, in rural areas where guns are more acceptable than in other parts of the United States, partners of IPV victims are considerably more likely to carry weapons than partners of nonabused women. Given the geographic limitations to police and medical response to severe IPV in a rural setting, an improved understanding of IPV risk among this population can aid health care providers in ascertaining risk before it escalates further. PMID:18624102

  11. The effect of physical attractiveness comparison on choice of partners.

    PubMed

    Kowner, R

    1995-04-01

    The roles of several presumed factors in the choice of partners during a first group encounter were examined, when the only available information was a ranking of group members' physical attractiveness. After they had received bogus feedback about their own attractiveness rank in a newly formed group, 99 Japanese students were asked to choose a partner for a task. The results indicated that feedback about one's own attractiveness was the primary factor that determined choice of others and that susceptibility to this type of feedback was characterized by a notable gender difference. These findings suggest that when the only information available about others concerns their physical appearance, the choice of partner or competitor, even for appearance-irrelevant tasks, is partially dependent on others' rankings of one's own physical attractiveness. PMID:7776639

  12. The Strategic Partners Network's Extraction: The XStrat.Net Project

    NASA Astrophysics Data System (ADS)

    Taifi, Nouha; Passiante, Giuseppina

    The firms in the business environment have to choose adequate partners in order to sustain their competitive advantage and their economic performance. Plus, the creation of special communities consisting of these partners is essential for the life-long development of these latter and the firms creating them. The research project XStrat.Net aims at the identification of factors and indicators about the organizations for the modelling of intelligent agents -XStrat intelligent agents- and the engineering of a software -XStrat- to process these backbones intelligent agents. Through the use of the software, the firms will be able to select the needed partners for the creation of special communities for the purpose of learning, interest or innovation. The XStrat.Net project also intends to provide guidelines for the creation of the special communities.

  13. Future research on gender symmetry in physical assaults on partners.

    PubMed

    Straus, Murray A

    2006-11-01

    In the light of evidence from about 200 studies showing gender symmetry in perpetration of partner assault, research can now focus on why gender symmetry is predominant and on the implications of symmetry for primary prevention and treatment of partner violence. Progress in such research is handicapped by a number of problems: (1) Insufficient empirical research and a surplus of discussion and theory, (2) Blinders imposed by commitment to a single causal factor theory-patriarchy and male dominance-in the face of overwhelming evidence that this is only one of a multitude of causes, (3) Research purporting to investigate gender differences but which obtains data on only one gender, (4) Denial of research grants to projects that do not assume most partner violence is by male perpetrators, (5) Failure to investigate primary prevention and treatment programs for female offenders, and (6) Suppression of evidence on female perpetration by both researchers and agencies. PMID:17043370

  14. Forgiveness increases the likelihood of subsequent partner transgressions in marriage.

    PubMed

    McNulty, James K

    2010-12-01

    Despite a growing literature on the positive implications of forgiveness and recent efforts to promote forgiveness in marriage, there is reason to believe forgiveness could have yet-unknown negative implications. In particular, forgiveness may increase the likelihood that offenders will offend again by removing unwanted outcomes for those offenders (e.g., criticism, guilt, loneliness) that would otherwise discourage them from reoffending. Consistent with this possibility, the current 7-day-diary study revealed that newlywed spouses were more likely to report that their partners had engaged in a negative behavior on days after they had forgiven those partners for a negative behavior than on days after they had not forgiven those partners for a negative behavior. Interpersonal theories and interventions designed to treat and prevent relationship distress may benefit by acknowledging this potential cost of forgiveness. PMID:21171779

  15. The Baltics: Regional energy profiles

    SciTech Connect

    Not Available

    1993-01-01

    However, all three Baltic Republics are heavily dependent on primary energy imports. Domestic energy sources in the Baltics are limited to oil shale mines in Estonia, small oil deposits in Lithuania, peat, and some very small hydroelectric power plants. A RBMK nuclear power station, similar to Chernobyl, operates at Snieckus in Lithuania, but the reactor fuel is also imported from Russia. However, Lithuania and Estonia are net exporters of electricity despite their reliance on primary fuels imports. The major power stations in these two Republics are the Ignalina Nuclear Power Station and the two thermal power plants at Narva in Estonia which are fueled by oil shale. The only oil refinery in the Baltics is also located in Lithuania, at Mazeikiai. This refinery has the capacity to satisfy the demand for selected refined products of the entire region, including the Kaliningrad oblast, a noncontiguous part of Russia. The Mazeikiai refinery has operated at only forty to sixty percent capacity since 1990 due to halts in crude oil supplies from Russia. The Baltic Republics also import one hundred percent of their coal and natural gas supplies. Russia is the main trading partner for all the Baltic states, accounting for more than half of their trade flow. Mutual trade within the Baltics has been surprisingly low. Other Baltic states contribute less than ten percent to each Republic`s exports or imports, even less than Belarus or Ukraine. Aside from Russia, Ukraine, and Belarus, only Kazakhstan contributes more than two percent to Baltics trade.

  16. The Baltics: Regional energy profiles

    SciTech Connect

    Not Available

    1993-01-01

    However, all three Baltic Republics are heavily dependent on primary energy imports. Domestic energy sources in the Baltics are limited to oil shale mines in Estonia, small oil deposits in Lithuania, peat, and some very small hydroelectric power plants. A RBMK nuclear power station, similar to Chernobyl, operates at Snieckus in Lithuania, but the reactor fuel is also imported from Russia. However, Lithuania and Estonia are net exporters of electricity despite their reliance on primary fuels imports. The major power stations in these two Republics are the Ignalina Nuclear Power Station and the two thermal power plants at Narva in Estonia which are fueled by oil shale. The only oil refinery in the Baltics is also located in Lithuania, at Mazeikiai. This refinery has the capacity to satisfy the demand for selected refined products of the entire region, including the Kaliningrad oblast, a noncontiguous part of Russia. The Mazeikiai refinery has operated at only forty to sixty percent capacity since 1990 due to halts in crude oil supplies from Russia. The Baltic Republics also import one hundred percent of their coal and natural gas supplies. Russia is the main trading partner for all the Baltic states, accounting for more than half of their trade flow. Mutual trade within the Baltics has been surprisingly low. Other Baltic states contribute less than ten percent to each Republic's exports or imports, even less than Belarus or Ukraine. Aside from Russia, Ukraine, and Belarus, only Kazakhstan contributes more than two percent to Baltics trade.

  17. Violence in Childhood, Attitudes about Partner Violence, and Partner Violence Perpetration among Men in Vietnam

    PubMed Central

    Pham, Huyen Tran; Minh, Tran Hung; Krause, Kathleen H.; Schuler, Sidney Ruth; Anh, Hoang Tu; VanderEnde, Kristin; Kramer, Michael R.

    2014-01-01

    Purpose We assess the association of men's exposure to violence in childhood--witnessing physical violence against one’s mother and being hit or beaten by a parent or adult relative--with their attitudes about intimate partner violence (IPV) against women. We explore whether men’s perpetration of IPV mediates this relationship and whether men’s attitudes about IPV mediate any relationship of exposure to violence in childhood with perpetration of IPV. Methods 522 married men 18–51 years in Vietnam were interviewed. Multivariate regressions for ordinal and binary responses were estimated to assess these relationships. Results Compared to men experiencing neither form of violence in childhood, men experiencing either or both had higher adjusted odds of reporting more reasons to hit a wife (aORs, 95%CIs: 1.43, 1.03–2.00 and 1.66, 1.05–2.64, respectively). Men’s lifetime perpetration of IPV accounted fully for these associations. Compared to men experiencing neither form of violence in childhood, men experiencing either or both had higher adjusted odds of ever perpetrating IPV (aORs, 95%CIs: 3.28, 2.15–4.99 and 4.56, 2.90–7.17, respectively). Attitudes about IPV modestly attenuated these associations. Conclusion Addressing violence in childhood is needed to change men’s risk of perpetrating IPV and greater subsequent justification of it. PMID:24630242

  18. Partner Pressure, Victimization History, and Alcohol: Women's Condom-Decision Abdication Mediated by Mood and Anticipated Negative Partner Reaction.

    PubMed

    George, William H; Davis, Kelly Cue; Masters, N Tatiana; Kajumulo, Kelly F; Stappenbeck, Cynthia A; Norris, Jeanette; Heiman, Julia R; Staples, Jennifer M

    2016-01-01

    Highly intoxicated versus sober women were evaluated using multi-group path analyses to test the hypothesis that sexual victimization history would interact with partner pressure to forgo condom use, resulting in greater condom-decision abdication-letting the man decide whether or not to use a condom. After beverage administration, community women (n = 408) projected themselves into a scenario depicting a male partner exerting high or low pressure for unprotected sex. Mood, anticipated negative reactions from the partner, and condom-decision abdication were assessed. In both control and alcohol models, high pressure increased anticipated negative partner reaction, and positive mood was associated with increased abdication. In the alcohol model, victimization predicted abdication via anticipated negative partner reaction, and pressure decreased positive mood and abdication. In the control model, under high pressure, victimization history severity was positively associated with abdication. Findings implicate condom-decision abdication as an important construct in understanding how women's sexual victimization histories may exert sustained impact on sexual interactions. PMID:26340952

  19. Partnering to Enhance Planetary Science Education and Public Outreach Program

    NASA Astrophysics Data System (ADS)

    Dalton, Heather; Shipp, Stephanie; Shupla, Christine; Shaner, Andrew; LaConte, Keliann

    2015-11-01

    The Lunar and Planetary Institute (LPI) in Houston, Texas utilizes many partners to support its multi-faceted Education and Public Outreach (E/PO) program. The poster will share what we have learned about successful partnerships. One portion of the program is focused on providing training and NASA content and resources to K-12 educators. Teacher workshops are performed in several locations per year, including LPI and the Harris County Department of Education, as well as across the country in cooperation with other programs and NASA Planetary Science missions.To serve the public, LPI holds several public events per year called Sky Fest, featuring activities for children, telescopes for night sky viewing, and a short scientist lecture. For Sky Fest, LPI partners with the NASA Johnson Space Center Astronomical Society; they provide the telescopes and interact with members of the public as they are viewing celestial objects. International Observe the Moon Night (InOMN) is held annually and involves the same aspects as Sky Fest, but also includes partners from Johnson Space Center’s Astromaterials Research and Exploration Science group, who provide Apollo samples for the event.Another audience that LPI E/PO serves is the NASA Planetary Science E/PO community. Partnering efforts for the E/PO community include providing subject matter experts for professional development workshops and webinars, connections to groups that work with diverse and underserved audiences, and avenues to collaborate with groups such as the National Park Service and the Afterschool Alliance.Additional information about LPI’s E/PO programs can be found at http://www.lpi.usra.edu/education. View a list of LPI E/PO’s partners here: http://www.lpi.usra.edu/education/partners/.

  20. Partnering to Enhance Planetary Science Education and Public Outreach Programs

    NASA Astrophysics Data System (ADS)

    Dalton, H.; Shipp, S. S.; Shupla, C. B.; Shaner, A. J.; LaConte, K.

    2015-12-01

    The Lunar and Planetary Institute (LPI) in Houston, Texas utilizes many partners to support its multi-faceted Education and Public Outreach (E/PO) program. The poster will share what we have learned about successful partnerships. One portion of the program is focused on providing training and NASA content and resources to K-12 educators. Teacher workshops are performed in several locations per year, including LPI and the Harris County Department of Education, as well as across the country in cooperation with other programs and NASA Planetary Science missions. To serve the public, LPI holds several public events per year called Sky Fest, featuring activities for children, telescopes for night sky viewing, and a short scientist lecture. For Sky Fest, LPI partners with the NASA Johnson Space Center Astronomical Society; they provide the telescopes and interact with members of the public as they are viewing celestial objects. International Observe the Moon Night (InOMN) is held annually and involves the same aspects as Sky Fest, but also includes partners from Johnson Space Center's Astromaterials Research and Exploration Science group, who provide Apollo samples for the event. Another audience that LPI E/PO serves is the NASA Planetary Science E/PO community. Partnering efforts for the E/PO community include providing subject matter experts for professional development workshops and webinars, connections to groups that work with diverse and underserved audiences, and avenues to collaborate with groups such as the National Park Service and the Afterschool Alliance. Additional information about LPI's E/PO programs can be found at http://www.lpi.usra.edu/education. View a list of LPI E/PO's partners here: http://www.lpi.usra.edu/education/partners/.

  1. Lovestruck: women, romantic love and intimate partner violence.

    PubMed

    Power, Charmaine; Koch, Tina; Kralik, Debbie; Jackson, Debra

    2006-05-01

    Intimate Partner Violence remains a significant problem globally despite health promotion aimed at raising awareness. In particular, there is a current trend for many young women to view some abusive/violent behaviours as acceptable in their relationships. Intimate Partner Violence has serious implications for its short and long term impacts on the health of women and children. Health workers may find working with women a challenging and sometimes frustrating experience. A way forward is to develop clearer understandings of the complexities of Intimate Partner Violence and to better understand women's investments in romantic relationships. In this paper a secondary analysis of data from a narrative study of women's recovery from IPV relationships is presented in order to illustrate discourses that inform underpinnings of romantic relationships. Transcriptions of audio-taped interviews were analysed using a feminist post-structural approach in order to make visible the ways in which the women negotiated their identities in the discourses of femininity. A critical review of current literature was also undertaken to develop the construct of romantic love. Women revealed that cues for Intimate Partner Violence were present early in the relationship but were not recognised at the time. Two positions within the discourse of romantic love were identified that underpinned their desires to establish and invest in the relationship despite the presence of cues for Intimate Partner Violence. These were 'Desperate for a man' and interpreting jealousy as a sign of love. Romantic love may be desirable for the sharing of warmth, safety and protection, and yet can mask behaviours that are cues for domestic violence. Understanding the complex nature of the ways that women's desires are located in the discourse of romantic love has implications for all nurses working to prevent and reduce the incidence of Intimate Partner Violence. PMID:16696600

  2. Experiences and socialization of Jamaican men with multiple sex partners.

    PubMed

    Simeon, D T; LeFranc, E; Bain, B; Wyatt, G E

    1999-12-01

    One of the goals of the Acquired Immunodeficiency Syndrome (AIDS) control programme in Jamaica is to encourage persons to have a single sex partner. Before this can be achieved in men, it is important to identify the demographic characteristics as well as the sexual attitudes and socialization of men who have multiple sex partners. A national survey was conducted on sexual decision-making in Jamaica in which a random sample of 3,001 persons was selected for study and of 2,580 (86%) interviewed 979 were men. The following analyses included the 769 men who were sexually active. Thirty-four per cent (34%), 95% CI, 30.6-37.4%) of these men said that they were currently having sex with more than one woman. Although condom use was higher in men with multiple sex partners, 33% of them said that they never used condoms. Independent predictors of having multiple sex partners were: not being in a stable union; being raised by fathers only; and having a secondary school education. There was no significant association with church attendance or with occupation. Compared with other males, men who had multiple sex partners started having sex at an earlier age and were more likely to engage in high-risk sex behaviours such as having sex with prostitutes and abusing drugs prior to coitus. They were also more likely to believe in the use of sex as a means to control their partners and were less likely to think that being married or involved in a long-term relationship was important. These data must be taken into consideration by the AIDS control programme in Jamaica when formulating policies to promote monogamy. There may also be a need to implement parenting support or education programmes for single men who raise their sons. PMID:10639842

  3. Midwest Nuclear Science and Engineering Consortium

    SciTech Connect

    Dr. Wynn Volkert; Dr. Arvind Kumar; Dr. Bryan Becker; Dr. Victor Schwinke; Dr. Angel Gonzalez; Dr. DOuglas McGregor

    2010-12-08

    The objective of the Midwest Nuclear Science and Engineering Consortium (MNSEC) is to enhance the scope, quality and integration of educational and research capabilities of nuclear sciences and engineering (NS/E) programs at partner schools in support of the U.S. nuclear industry (including DOE laboratories). With INIE support, MNSEC had a productive seven years and made impressive progress in achieving these goals. Since the past three years have been no-cost-extension periods, limited -- but notable -- progress has been made in FY10. Existing programs continue to be strengthened and broadened at Consortium partner institutions. The enthusiasm generated by the academic, state, federal, and industrial communities for the MNSEC activities is reflected in the significant leveraging that has occurred for our programs.

  4. Identification of Cell Cycle Dependent Interaction Partners of the Septins by Quantitative Mass Spectrometry.

    PubMed

    Renz, Christian; Oeljeklaus, Silke; Grinhagens, Sören; Warscheid, Bettina; Johnsson, Nils; Gronemeyer, Thomas

    2016-01-01

    The septins are a conserved family of GTP-binding proteins that, in the baker's yeast, assemble into a highly ordered array of filaments at the mother bud neck. These filaments undergo significant structural rearrangements during the cell cycle. We aimed at identifying key components that are involved in or regulate the transitions of the septins. By combining cell synchronization and quantitative affinity-purification mass-spectrometry, we performed a screen for specific interaction partners of the septins at three distinct stages of the cell cycle. A total of 83 interaction partners of the septins were assigned. Surprisingly, we detected DNA-interacting/nuclear proteins and proteins involved in ribosome biogenesis and protein synthesis predominantly present in alpha-factor arrested that do not display an assembled septin structure. Furthermore, two distinct sets of regulatory proteins that are specific for cells at S-phase with a stable septin collar or at mitosis with split septin rings were identified. Complementary methods like SPLIFF and immunoprecipitation allowed us to more exactly define the spatial and temporal characteristics of selected hits of the AP-MS screen. PMID:26871441

  5. Does neighborhood environment differentiate intimate partner femicides from other femicides?

    PubMed

    Beyer, Kirsten M M; Layde, Peter M; Hamberger, L Kevin; Laud, Purushottam W

    2015-01-01

    We examined the association between neighborhood-level factors and intimate partner femicide (IPF) using Wisconsin Violent Death Reporting System (WVDRS) data and Wisconsin Coalition Against Domestic Violence (WCADV) reports, in concert with neighborhood-level information. After controlling for individual characteristics, neighborhood-level disadvantage was associated with a decreased likelihood of IPF status, as compared with other femicides, whereas neighborhood-level residential instability was associated with an increased likelihood of IPF status. Neighborhood plays a role in differentiating IPFs from other femicides in our study area. Our findings demonstrate the importance of multilevel strategies for understanding and reducing the burden of intimate partner violence. PMID:25540251

  6. Normative Misperceptions of Abuse Among Perpetrators of Intimate Partner Violence

    PubMed Central

    Neighbors, Clayton; Walker, Denise D.; Mbilinyi, Lyungai F.; O’Rourke, Allison; Edleson, Jeffrey L.; Zegree, Joan; Roffman, Roger A.

    2012-01-01

    This research was designed to evaluate the applicability of social norms approaches to interventions with male perpetrators of intimate partner violence (IPV). Participants included 124 nonadjudicated IPV perpetrating men recruited from the general population who completed assessment of their own IPV behaviors via telephone interviews and estimated the prevalence of behaviors in other men. Results indicated that IPV perpetrators consistently overestimated the percentage of men who engaged in IPV and that their estimates were associated with violence toward their partner over the past 90 days. Findings provide preliminary support for incorporating social norms approaches into clinical applications. PMID:20200408

  7. First same-sex partner and the internet.

    PubMed

    Franssens, Dirk; Hospers, Harm J; Kok, Gerjo

    2010-12-01

    The present study examined the first episode of anal intercourse of young gay and bisexual men (YGBM) who were in the midst of their coming-out. Cross-sectional data regarding the first episode of anal intercourse were extracted from Outcomes, a longitudinal study on coming-out and sexual behavior of YGBM in the Netherlands. Overall, 45% of respondents reported unprotected anal intercourse (UAI) with their first same-sex partner. Rates of UAI did not significantly differ between meeting place (offline vs. online) and partner status (steady, regular or casual). PMID:20300819

  8. DOES NEIGHBORHOOD ENVIRONMENT DIFFERENTIATE INTIMATE PARTNER FEMICIDES FROM OTHER FEMICIDES?

    PubMed Central

    Beyer, Kirsten M. M.; Layde, Peter M.; Hamberger, L. Kevin; Laud, Purushottam W.

    2015-01-01

    We examined the association between neighborhood-level factors and intimate partner femicide (IPF) using Wisconsin Violent Death Reporting System (WVDRS) data and Wisconsin Coalition Against Domestic Violence (WCADV) reports, in concert with neighborhood-level information. After controlling for individual characteristics, neighborhood-level disadvantage was associated with a decreased likelihood of IPF status, as compared to other femicides, while neighborhood-level residential instability was associated with an increased likelihood of IPF status. Neighborhood plays a role in differentiating IPFs from other femicides in our study area. Our findings demonstrate the importance of multilevel strategies for understanding and reducing the burden of intimate partner violence. PMID:25540251

  9. Partners or rivals? Strategies for the iterated prisoner's dilemma☆

    PubMed Central

    Hilbe, Christian; Traulsen, Arne; Sigmund, Karl

    2015-01-01

    Within the class of memory-one strategies for the iterated Prisoner's Dilemma, we characterize partner strategies, competitive strategies and zero-determinant strategies. If a player uses a partner strategy, both players can fairly share the social optimum; but a co-player preferring an unfair solution will be penalized by obtaining a reduced payoff. A player using a competitive strategy never obtains less than the co-player. A player using a zero-determinant strategy unilaterally enforces a linear relation between the two players' payoffs. These properties hold for every strategy used by the co-player, whether memory-one or not. PMID:26339123

  10. Intimate Partner Violence Among Mothers of Sick Newborns in Ghana.

    PubMed

    Spangenberg, Kathryn; Wobil, Priscilla; Betts, Cassandra L; Wiesner, Theodore F; Gold, Katherine J

    2016-05-01

    Intimate partner violence (IPV) is a major public health problem estimated to affect 15%-71% of women worldwide. We sought to elicit IPV risks among mothers of sick newborns in Ghana. As part of a broader study on postpartum depression, we conducted semistructured surveys of 153 women in a mother-baby unit, assessing demographics, depression, social support, and IPV with the present partner. Forty-six percent of mothers reported some form of violence, mostly emotional (34%), followed by physical (17%), and sexual (15%). The study highlights the frequency of perinatal IPV and the associated risk factors of depression and poor social support. PMID:25864483

  11. Teen Mothers' Experience of Intimate Partner Violence: A Metasynthesis.

    PubMed

    Bekaert, Sarah; SmithBattle, Lee

    2016-01-01

    Pregnant and parenting teens suffer higher rates of intimate partner violence (IPV) than older mothers. This qualitative metasynthesis explores teen mothers' experience with IPV during pregnancy and postpartum. Organized by the metaphor of a web, findings highlight how pervasive violence during childhood contributes to teen pregnancy and the risk of IPV as violence is normalized. The web constricts through the partner's control as violence emerges or worsens with pregnancy. Young mothers become increasingly isolated, and live with the physical and psychological consequences of IPV. Trauma-informed nursing practice is needed to support teen mothers in violent intimate relationships to spin a new web. PMID:27490882

  12. Intimate partner violence after the diagnosis of sexually transmitted diseases

    PubMed Central

    Andrade, Roumayne Fernandes Vieira; Araújo, Maria Alix Leite; Vieira, Luiza Jane Eyre de Souza; Reis, Cláudia Bastos Silveira; Miranda, Angélica Espinosa

    2015-01-01

    OBJECTIVE To assess the prevalence and factors associated with intimate partner violence after the diagnosis of sexually transmitted diseases. METHODS This cross-sectional study was conducted in Fortaleza, CE, Northeastern Brazil, in 2012 and involved 221 individuals (40.3% male and 59.7% female) attended to at reference health care units for the treatment of sexually transmitted diseases. Data were collected using a questionnaire applied during interviews with each participant. A multivariate analysis with a logistic regression model was conducted using the stepwise technique. Only the variables with a p value < 0.05 were included in the adjusted analysis. The odds ratio (OR) with 95% confidence interval (CI) was used as the measure of effect. RESULTS A total of 30.3% of the participants reported experiencing some type of violence (27.6%, psychological; 5.9%, physical; and 7.2%, sexual) after the diagnosis of sexually transmitted disease. In the multivariate analysis adjusted to assess intimate partner violence after the revelation of the diagnosis of sexually transmitted diseases, the following variables remained statistically significant: extramarital relations (OR = 3.72; 95%CI 1.91;7.26; p = 0.000), alcohol consumption by the partner (OR = 2.16; 95%CI 1.08;4.33; p = 0.026), history of violence prior to diagnosis (OR = 2.87; 95%CI 1.44;5.69; p = 0.003), and fear of disclosing the diagnosis to the partner (OR = 2.66; 95%CI 1.32;5.32; p = 0.006). CONCLUSIONS Individuals who had extramarital relations, experienced violence prior to the diagnosis of sexually transmitted disease, feared disclosing the diagnosis to the partner, and those whose partner consumed alcohol had an increased likelihood of suffering violence. The high prevalence of intimate partner violence suggests that this population is vulnerable and therefore intervention efforts should be directed to them. Referral health care services for the treatment of sexually transmitted diseases can be strategic

  13. Cohabitation with a sick partner increases allergic lung inflammatory response in mice.

    PubMed

    Hamasato, Eduardo Kenji; de Lima, Ana Paula Nascimento; de Oliveira, Ana Paula Ligeiro; dos Santos Franco, Adriana Lino; de Lima, Wothan Tavares; Palermo-Neto, João

    2014-11-01

    results suggest that allergic lung inflammatory response exacerbation in CSP mice is a consequence of the psychological stress induced by forced cohabitation with the sick partner. Strong involvement of the sympathetic nervous system (SNS) through adrenaline and noradrenaline release and a shift of the Th1/Th2 cytokine profile toward a Th2 response were considered to be the mechanisms underlying the cell recruitment to the animal's airways. PMID:24929194

  14. Small Heterodimer Partner (NR0B2) Coordinates Nutrient Signaling and the Circadian Clock in Mice.

    PubMed

    Wu, Nan; Kim, Kang Ho; Zhou, Ying; Lee, Jae Man; Kettner, Nicole M; Mamrosh, Jennifer L; Choi, Sungwoo; Fu, Loning; Moore, David D

    2016-09-01

    Circadian rhythm regulates multiple metabolic processes and in turn is readily entrained by feeding-fasting cycles. However, the molecular mechanisms by which the peripheral clock senses nutrition availability remain largely unknown. Bile acids are under circadian control and also increase postprandially, serving as regulators of the fed state in the liver. Here, we show that nuclear receptor Small Heterodimer Partner (SHP), a regulator of bile acid metabolism, impacts the endogenous peripheral clock by directly regulating Bmal1. Bmal1-dependent gene expression is altered in Shp knockout mice, and liver clock adaptation is delayed in Shp knockout mice upon restricted feeding. These results identify SHP as a potential mediator connecting nutrient signaling with the circadian clock. PMID:27427832

  15. NTP system simulation and detailed nuclear engine modeling

    NASA Technical Reports Server (NTRS)

    Anghaie, Samim

    1993-01-01

    The topics are presented in viewgraph form and include the following: nuclear thermal propulsion (NTP) & detailed nuclear engine modeling; modeling and engineering simulation of nuclear thermal rocket systems; nuclear thermal rocket simulation system; INSPI-NTVR core axial flow profiles; INSPI-NTRV core axial flow profiles; specific impulse vs. chamber pressure; turbine pressure ratio vs. chamber pressure; NERVA core axial flow profiles; P&W XNR2000 core axial flow profiles; pump pressure rise vs. chamber pressure; streamline of jet-induced flow in cylindrical chamber; flow pattern of a jet-induced flow in a chamber; and radiative heat transfer models.

  16. [An economic evaluation of intimate partner violence in France].

    PubMed

    Nectoux, Marc; Mugnier, Claude; Baffert, Sandrine; Albagly, Maité; Thélot, Bertrand

    2010-01-01

    This study aims to carry out an economic evaluation of intimate partner violence in France. Using published data, institutional sources, field studies and expert opinions, the cost of intimate partner violence is estimated in terms of the overall cost to society. A range of different economic approaches are used (micro-economic, meso-economic and macro-economic approaches). The total cost of intimate partner violence in France is estimated at 2.5 billion Euros per year (between 1.7 and 3.5 billion Euros). The total cost of intimate partner violence includes healthcare costs (483 ? million), social and justice services (355 ? million), production losses as a result of deaths, imprisonments and absenteeism (1099 ? million), and the human costs of rape and prejudice (535 ? million). By increasing the budget allocated to the prevention of domestic violence by one euro, it is estimated that the state, health insurance and local authorities could make savings of up to 87 Euros of social spending, including 30 Euros of direct expenses. PMID:20858339

  17. Methodological Review of Intimate Partner Violence Prevention Research

    ERIC Educational Resources Information Center

    Murray, Christine E.; Graybeal, Jennifer

    2007-01-01

    The authors present a methodological review of empirical program evaluation research in the area of intimate partner violence prevention. The authors adapted and utilized criterion-based rating forms to standardize the evaluation of the methodological strengths and weaknesses of each study. The findings indicate that the limited amount of…

  18. Gender and Intimate Partner Violence: Evaluating the Evidence

    ERIC Educational Resources Information Center

    Gilfus, Mary E.; Trabold, Nicole; O'Brien, Patricia; Fleck-Henderson, Ann

    2010-01-01

    Intimate partner violence (IPV) is a complex social problem that social workers must be trained to address, using the best available evidence. In this article we review divergent theories, research findings, and methods that underpin debates about the role of gender in IPV perpetration and victimization. We examine the literature that…

  19. Partnering at Superfund sites -- a win-win situation

    SciTech Connect

    Neumann, M.G.; Ohlinger, B.

    1994-12-31

    Combining today`s litigious society with shrinking profit margins for Superfund contractors results in adversarial relationships among all parties involved in Superfund site remediation, such as regulatory agencies, designers, contractors, suppliers and owners. These negative relationships have a detrimental effect on the project at hand. Partnering is an available solution to the problem and creates a win-win situation for everyone. This presentation defines partnering, describes the process and gives real-world examples from two Superfund Sites, citing successes and giving tips on how to make partnering work for you. Partnering is working at the Bofors-Nobel Superfund Site in Muskegon, Michigan. Located six miles east of downtown Muskegon, the 85-acre Bofors site includes an active chemical production facility, an unused landfill, and abandoned sludge lagoons. Used for chemical manufacturing since the early 1960s, soil and groundwater at Bofors-Nobel are contaminated with pesticides, dye intermediates, aromatic hydrocarbons, and chlorinated organic compounds. Within 13 miles of the Bofors site is the Ott/Story/Cordova Superfund site. The 1.35 mgd groundwater treatment facility under construction there will surpass the capacity of the Bofors plant by nearly a quarter-million gallons per day. The 20-acre Ott/Story/Cordova site sits on more than 1 billion gallons of groundwater contaminated with chlorides, phenols, volatile organic compounds, and heavy metals which have percolated through the sandy soil of wastewater lagoons.

  20. Partnering with Librarians to Meet NCATE Standards in Teacher Education

    ERIC Educational Resources Information Center

    Birch, Tobeylynn; Greenfield, Louise; Janke, Karen; Schaeffer, Deborah; Woods, Ada

    2008-01-01

    As colleges of education prepare to meet NCATE standards they will find technically savvy allies and willing partners at their campus libraries. The information literacy and technology targets in the standards of the National Council for Accreditation of Teacher Education (NCATE) parallel the information literacy standards developed by the…

  1. Gender Differences in Intended Escalatory Tendencies among Marital Partners

    ERIC Educational Resources Information Center

    Winstok, Zeev; Straus, Murray A.

    2011-01-01

    This study addresses the intended escalatory tendency in eight hypothetical situations in which the provocator's identity (partner or stranger, male or female) and the provocation form (verbal or physical aggression) were manipulated. The research question is "how does the identity of the provocator and the form of his or her provocation affect…

  2. Faculty and Community Partners in Gerontological Curriculum Enrichment

    ERIC Educational Resources Information Center

    Dorfman, Lorraine T.; Murty, Susan A.; Ingram, Jerry G.; Li, Han

    2008-01-01

    This study examined outcomes for faculty and community partners of a gerontological curriculum enrichment effort at a midwestern state university. The study was supported by the John A. Hartford Foundation. Faculty from three academic centers around the state were involved in revising the foundation (core) curriculum. Community practitioners from…

  3. An eMERGE Clinical Center at Partners Personalized Medicine

    PubMed Central

    Smoller, Jordan W.; Karlson, Elizabeth W.; Green, Robert C.; Kathiresan, Sekar; MacArthur, Daniel G.; Talkowski, Michael E.; Murphy, Shawn N.; Weiss, Scott T.

    2016-01-01

    The integration of electronic medical records (EMRs) and genomic research has become a major component of efforts to advance personalized and precision medicine. The Electronic Medical Records and Genomics (eMERGE) network, initiated in 2007, is an NIH-funded consortium devoted to genomic discovery and implementation research by leveraging biorepositories linked to EMRs. In its most recent phase, eMERGE III, the network is focused on facilitating implementation of genomic medicine by detecting and disclosing rare pathogenic variants in clinically relevant genes. Partners Personalized Medicine (PPM) is a center dedicated to translating personalized medicine into clinical practice within Partners HealthCare. One component of the PPM is the Partners Healthcare Biobank, a biorepository comprising broadly consented DNA samples linked to the Partners longitudinal EMR. In 2015, PPM joined the eMERGE Phase III network. Here we describe the elements of the eMERGE clinical center at PPM, including plans for genomic discovery using EMR phenotypes, evaluation of rare variant penetrance and pleiotropy, and a novel randomized trial of the impact of returning genetic results to patients and clinicians. PMID:26805891

  4. Pros and Cons of Partnering: A VCampus Perspective.

    ERIC Educational Resources Information Center

    Stallings, Dees

    2001-01-01

    Discussion of the growth of online courses in higher education and outsourcing for online course development focuses on the work of VCampus, an application service provider that develops online instruction for corporations and academic institutions. Discusses partnering arrangements; merging goals; intellectual property rights; marketing plans;…

  5. How Children and Their Caregivers Adjust after Intimate Partner Femicide

    ERIC Educational Resources Information Center

    Hardesty, Jennifer L.; Campbell, Jacquelyn C.; McFarlane, Judith M.; Lewandowski, Linda A.

    2008-01-01

    Approximately 3,300 children are affected by intimate partner femicide each year. Despite the multitude of stressors and the potential for negative outcomes, little is known about these children or their caregivers. This in-depth interview study used family stress theory to explore caregivers' and children's adjustment after intimate partner…

  6. Partnering to Enhance Education and Public Engagement Programs

    NASA Technical Reports Server (NTRS)

    Shupla, C.; Bialeschki, D.; Buxner, S.; Felske, L.; Foxworth, S.; Graff, P.; Peticolas, L.; Shaner, A.; Hackler, A. Smith

    2016-01-01

    Collaborating with partners is a fundamental aspect of the Lunar and Planetary Institute's (LPI) educational and public engagement efforts. Such partnerships enable scientists and educators to include members of the audience in program planning and execution. Ultimately, partnerships strengthen programs by providing diverse resources, expertise, and expanding the potential audience.

  7. Child and Adolescent Predictors of Male Intimate Partner Violence

    ERIC Educational Resources Information Center

    Theobald, Delphine; Farrington, David P.

    2012-01-01

    Background: This study addresses to what extent child and adolescent explanatory factors predict male perpetrated intimate partner violence (IPV) in adulthood. Methods: We use prospective longitudinal data from the Cambridge Study in Delinquent Development (CSDD). The CSDD is a survey of 411 male born in the 1950s in an inner London area. The men…

  8. College and Industry: Partners in the Handicapped Employment Role (CIPHER).

    ERIC Educational Resources Information Center

    Schneps, Jack A.; Katz, David

    Presented is a report of the CIPHER (College and Industry--Partners in the Handicapped Employment Role) program which involved statewide (New York) conference/workshops and a survey to expose industry and community college groups to the work capabilities, aspirations, and educational needs of disabled students. Information is provided on the three…

  9. The Conversational Partner's Perspective Affects Spatial Memory and Descriptions

    ERIC Educational Resources Information Center

    Galati, Alexia; Michael, Christina; Mello, Catherine; Greenauer, Nathan M.; Avraamides, Marios N.

    2013-01-01

    We examined whether people spontaneously represent the partner's viewpoint in spatial memory when it is available in advance and whether they adapt their spontaneous descriptions accordingly. In 18 pairs, Directors studied arrays of objects while: (1) not knowing about having to describe the array to a Matcher, (2) knowing about the subsequent…

  10. Characteristics of Victims Coarrested for Intimate Partner Violence

    ERIC Educational Resources Information Center

    Houry, Debra; Reddy, Sudha; Parramore, Constance

    2006-01-01

    This study evaluated the frequency of coarrest in female victims who utilized 911 for intimate partner violence (IPV) and any patterns or circumstances that increased the likelihood of coarrest. All cases of police-documented IPV where a female IPV victim was arrested in conjunction with the perpetrator were included. Each incident report was…

  11. Geographical variation in mutualistic networks: similarity, turnover and partner fidelity

    PubMed Central

    Trøjelsgaard, Kristian; Jordano, Pedro; Carstensen, Daniel W.; Olesen, Jens M.

    2015-01-01

    Although species and their interactions in unison represent biodiversity and all the ecological and evolutionary processes associated with life, biotic interactions have, contrary to species, rarely been integrated into the concepts of spatial β-diversity. Here, we examine β-diversity of ecological networks by using pollination networks sampled across the Canary Islands. We show that adjacent and distant communities are more and less similar, respectively, in their composition of plants, pollinators and interactions than expected from random distributions. We further show that replacement of species is the major driver of interaction turnover and that this contribution increases with distance. Finally, we quantify that species-specific partner compositions (here called partner fidelity) deviate from random partner use, but vary as a result of ecological and geographical variables. In particular, breakdown of partner fidelity was facilitated by increasing geographical distance, changing abundances and changing linkage levels, but was not related to the geographical distribution of the species. This highlights the importance of space when comparing communities of interacting species and may stimulate a rethinking of the spatial interpretation of interaction networks. Moreover, geographical interaction dynamics and its causes are important in our efforts to anticipate effects of large-scale changes, such as anthropogenic disturbances. PMID:25632001

  12. Leave or Stay? Battered Women's Decision after Intimate Partner Violence

    ERIC Educational Resources Information Center

    Kim, Jinseok; Gray, Karen A.

    2008-01-01

    Battered women's reasons for staying with or leaving their male partners are varied and complex. Using data from the Domestic Violence Experience in Omaha, Nebraska, a discrete-time hazard model was employed to examine a woman's decision based on four factors: financial independence, witness of parental violence, psychological factors, and the…

  13. Impact of Emergency Department Intimate Partner Violence Intervention

    ERIC Educational Resources Information Center

    Kendall, Jayne; Pelucio, Maria Tereza; Casaletto, Jennifer; Thompson, Karen Parker; Barnes, Sherry; Pettit, Erin; Aldrich, Mae

    2009-01-01

    The objective of the study is to assess the impact of emergency department (ED) intimate partner violence (IPV) counseling and resource referrals on patient-perceived safety and safety planning. ED patients with risk factors were offered consultation with trained IPV advocacy counselors who completed safety assessments, provided resource…

  14. A Caregiving Model of Coping with a Partner's Depression

    ERIC Educational Resources Information Center

    Jeglic, Elizabeth L.; Pepper, Carolyn M.; Ryabchenko, Karen A.; Griffith, James W.; Miller, Allison B.; Johnson, Matthew D.

    2005-01-01

    To test a caregiving model of depression in spouses, 31 married couples completed interview and questionnaire assessments of depressive symptoms and caregiving activities. Spouses living with a partner with depressive symptoms had more symptoms of depression themselves. However, this association was found to be fully mediated by spouses' perceived…

  15. Is Partner Violence Worse in the Context of Control?

    ERIC Educational Resources Information Center

    Anderson, Kristin L.

    2008-01-01

    M. P. Johnson's (1995) proposal that there are two qualitatively distinct types of intimate partner violence--intimate terrorism and situational couple violence--has been an influential explanation for disparate findings on sex symmetry in domestic violence. This study examines whether this typology increases our ability to explain variations in…

  16. MyTeachingPartner-Secondary. What Works Clearinghouse Intervention Report

    ERIC Educational Resources Information Center

    What Works Clearinghouse, 2015

    2015-01-01

    "MyTeachingPartner-Secondary (MTP-S)" is a professional development program that aims to increase student learning and development through improved teacher-student interactions. The program uses a classroom-assessment instrument to observe effective teaching practices and guide teachers' efforts to improve teacher-student interactions.…

  17. Does High Educational Attainment Limit the Availability of Romantic Partners?

    ERIC Educational Resources Information Center

    Burt, Isaac; Lewis, Sally V.; Beverly, Monifa G.; Patel, Samir H.

    2010-01-01

    Research indicates that highly educated individuals endure hardships in finding suitable romantic partners. Romantic hardships affect social and emotional adjustment levels, leading to low self-efficacy in relationship decision making. To address the need for research pertaining to this topic, the authors explored the experiences of eight…

  18. Correlates of Partner Violence for Incarcerated Women and Men

    ERIC Educational Resources Information Center

    Robertson, Kirsten; Murachver, Tamar

    2007-01-01

    This study examines partner violence within an incarcerated sample of women and men. Specifically, it focused on the relationship between explicit and implicit attitudes to the perpetration and victimization of violence. Findings revealed that violence was bidirectional, with males and females equally likely to report being the perpetrator or…

  19. Intimate Partner Violence among Male and Female Russian University Students

    ERIC Educational Resources Information Center

    Lysova, Aleksandra V.; Douglas, Emily M.

    2008-01-01

    This article reports data from three Russian sites of the International Dating Violence Study. Using a sample of 338 university students (54% female) from three Russian university sites, four different types of partner violence are examined: physical assault, physical injury, sexual coercion, and psychological aggression. High prevalence rates…

  20. Revisiting the Role of Communication in Adolescent Intimate Partner Violence

    ERIC Educational Resources Information Center

    Messinger, Adam M.; Rickert, Vaughn I.; Fry, Deborah A.; Lessel, Harriet; Davidson, Leslie L.

    2012-01-01

    A growing literature suggests that communication strategies can promote or inhibit intimate partner violence (IPV). Research on communication is still needed on a group ripe for early IPV intervention: high school-aged adolescents. This article revisits our previous analyses of young female reproductive clinic patients (Messinger, Davidson, &…

  1. Domestic Violence between Same-Sex Partners: Implications for Counseling.

    ERIC Educational Resources Information Center

    Peterman, Linda M.; Dixon, Charlotte G.

    2003-01-01

    Discusses the dynamics of domestic violence between partners of the same sex. The social and cultural issues in the gay and lesbian communities play a large part in perpetuating the myths of domestic violence, which keeps the abuse hidden. This article is based on an extensive review of the literature and a clinical consensus among experts in the…

  2. Arranged marriages, unlikely partners. How will their offspring look?

    PubMed

    Connors, E J

    1995-05-01

    In the new era of managed care, many religious healthcare providers are making "arranged marriages"--permanent partnerships with secular organizations. As they do so, the religious partners naturally ponder how best to ensure that their values permeate the new entity and thus prevail in later organizational "offspring." The organizations most likely to perpetuate their values are those with ethical corporate cultures and climates. These include religiously based healthcare providers, but such providers seem to lack confidence today in their ability to maintain culture and climate in newly formed partnerships. That may be fortunate because it prevents them from trying to impose their values on secular partners. Nevertheless, such values are often attractive to a prospective partner. A religious healthcare provider will need market leverage, as well as attractive values, to make a good "marriage." Even so, religious providers and secular investor-owned organizations are unlikely partners, because their motives and incentives differ radically. But religious providers can form solid relationships with secular, not-for-profit healthcare organizations if they take care to negotiate a binding commitment to maintain an ethical culture and climate. However, Catholic providers are at a disadvantage in such negotiations because Catholic religious congregations are unlikely to continue as owner-sponsors much beyond another decade. It is crucial that a stable source of influence develop to ensure a religious presence in the offspring of new partnerships. PMID:10142222

  3. 48 CFR 1852.236-75 - Partnering for construction contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Partnering for construction contracts. 1852.236-75 Section 1852.236-75 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Texts of Provisions and Clauses 1852.236-75...

  4. Depressive Symptoms in Women Experiencing Intimate Partner Violence

    ERIC Educational Resources Information Center

    Houry, Debra; Kaslow, Nadine J.; Thompson, Martie P.

    2005-01-01

    The study was a cross-sectional examination of African American women positive for intimate partner violence (IPV) who presented to the medical or psychiatric emergency department (ED) for treatment. African American women with a recent history of IPV who presented following an attempted suicide (n = 100) were compared to demographically…

  5. Risky Business: An Ecological Analysis of Intimate Partner Violence Disclosure

    ERIC Educational Resources Information Center

    Alaggia, Ramona; Regehr, Cheryl; Jenney, Angelique

    2012-01-01

    Objective: A multistage, mixed-methods study using grounded theory with descriptive data was conducted to examine factors in disclosure of intimate partner violence (IPV). Method: In-depth interviews with individuals and focus groups were undertaken to collect data from 98 IPV survivors and service providers to identify influential factors.…

  6. Intimate Partner Violence during Pregnancy and Mothers' Child Abuse Potential

    ERIC Educational Resources Information Center

    Casanueva, Cecilia E.; Martin, Sandra L.

    2007-01-01

    This research examines whether women who have experienced intimate partner violence (IPV) during pregnancy have a higher child abuse potential than women who have not experienced IPV. Data were analyzed from a longitudinal investigation of IPV during pregnancy. This study recruited 88 pregnant women during prenatal care and followed them for 1 1/2…

  7. Intimate Partner Violence and Welfare Participation: A Longitudinal Causal Analysis

    ERIC Educational Resources Information Center

    Cheng, Tyrone C.

    2013-01-01

    This longitudinal study examined the temporal-ordered causal relationship between intimate partner violence (IPV), five mental disorders (depression, generalized anxiety disorder, social phobia, panic attack, posttraumatic stress disorder [PTSD]), alcohol abuse/dependence, drug abuse/ dependence, treatment seeking (from physician, counselor, and…

  8. From Recipients to Partners: Children in Malaria Education in Uganda

    ERIC Educational Resources Information Center

    Nakiwala, Aisha Sembatya

    2016-01-01

    Purpose: Health education that integrates community participation is essential for malaria control. However, children's participation is not generally as active as that of adults, thus turning children into recipients, as opposed to partners in malaria control. The purpose of this paper is to develop a better understanding of how children can…

  9. Women's perception of partner violence in a rural Igbo community.

    PubMed

    Ilika, Amobi Linus

    2005-12-01

    Partner violence is a serious public health problem affecting mostly women. This qualitative study assessed the perceptions of rural Igbo women of Nigeria of intimate partner violence. Information was elicited using in-depth interviews and focus group discussion. Women of childbearing age were selected from the various women age grades in Ozubulu, Anambra State, Nigeria. Findings revealed that the women generally condone and are complacent with intimate partner violence, perceiving it as cultural and religious norms. The women felt that reprimands, beating and forced sex affecting their physical, mental and reproductive wellbeing are normal in marriage. They did not support reporting such cases to the police or divorcing the man, they would rather prefer reporting to family members. They felt that exiting the marriage would not gain the support of family members. They also expressed fear for the uncertainty in re-marrying, means of livelihood after re-marriage, social stigmatisation, and concern for their children. Socio-cultural norms and structures favour partner violence in Anambra State of Nigeria. There is a need for advocacy and concerted action that will involve the educational, health, civil and religious sectors of the society to evolve sustainable structures that will empower women and provide support to enable victims to react appropriately to violence. PMID:16623192

  10. Intimate Partner Violence in Colombia: Who Is at Risk?

    ERIC Educational Resources Information Center

    Friedemann-Sanchez, Greta; Lovaton, Rodrigo

    2012-01-01

    The role that domestic violence plays in perpetuating poverty is often overlooked as a development issue. Using data from the 2005 Demographic Health Survey, this paper examines the prevalence of intimate partner violence in Colombia. Employing an intrahousehold bargaining framework and a bivariate probit model, it assesses the prevalence of and…

  11. Perceptions of Help Resources for Victims of Intimate Partner Violence

    ERIC Educational Resources Information Center

    Krugman, Scott D.; Witting, Michael D.; Furuno, Jon P.; Hirshon, Jon Mark; Limcangco, Rhona; Perisse, Andre R. S.; Rasch, Elizabeth K.

    2004-01-01

    Intimate partner violence (IPV) constitutes a major public health problem in the United States. This cross-sectional survey of 108 emergency department (ED) care providers and 146 ED visitors at three metropolitan EDs compared the beliefs of ED health care providers with those of community members about the relative benefits of the helpfulness of…

  12. Public Schools as Partners in Rural Development: Considerations for Policymakers.

    ERIC Educational Resources Information Center

    Harmon, Hobart L.

    This paper describes four considerations for policymakers who wish to have public schools serve as viable partners in the rural development efforts of their communities. First, schools are a community resource. When rural students are given opportunities to engage in community-based learning, they develop responsible citizenship and leadership…

  13. Intimate Partner Violence in Interracial and Monoracial Couples

    ERIC Educational Resources Information Center

    Martin, Brittny A.; Cui, Ming; Ueno, Koji; Fincham, Frank D.

    2013-01-01

    This study, using a nationally representative sample, investigated intimate partner violence (IPV) in interracial and monoracial relationships. Regression analyses indicated that interracial couples demonstrated a higher level of mutual IPV than monoracial White couples but a level similar to monoracial Black couples. There were significant gender…

  14. Partner Choice Drives the Evolution of Cooperation via Indirect Reciprocity

    PubMed Central

    Roberts, Gilbert

    2015-01-01

    Indirect reciprocity potentially provides an important means for generating cooperation based on helping those who help others. However, the use of ‘image scores’ to summarize individuals’ past behaviour presents a dilemma: individuals withholding help from those of low image score harm their own reputation, yet giving to defectors erodes cooperation. Explaining how indirect reciprocity could evolve has therefore remained problematic. In all previous treatments of indirect reciprocity, individuals are assigned potential recipients and decide whether to cooperate or defect based on their reputation. A second way of achieving discrimination is through partner choice, which should enable individuals to avoid defectors. Here, I develop a model in which individuals choose to donate to anyone within their group, or to none. Whereas image scoring with random pairing produces cycles of cooperation and defection, with partner choice there is almost maximal cooperation. In contrast to image scoring with random pairing, partner choice results in almost perfect contingency, producing the correlation between giving and receiving required for cooperation. In this way, partner choice facilitates much higher and more stable levels of cooperation through image scoring than previously reported and provides a simple mechanism through which systems of helping those who help others can work. PMID:26057241

  15. Friendship-based partner switching promotes cooperation in heterogeneous populations

    NASA Astrophysics Data System (ADS)

    Chen, Wei; Wu, Te; Li, Zhiwu; Wang, Long

    2016-02-01

    The forming of human social ties tends to be with similar individuals. This study concentrates on the emergence of cooperation among heterogeneous populations. A simple model is proposed by considering the impact of interplay between the evolution of strategies and that of social partnerships on cooperation dynamics. Whenever two individuals acquire the rewards by playing prisoner's dilemma game with each other, the friendship (friendship is quantified as the weight of a link) between the two individuals deepens. Individuals can switch off the social ties with the partners who are unfriendly and rewire to similar new ones. Under this partner switching mechanism, population structure is divided into several groups and cooperation can prevail. It is observed that the frequent tendency of partner switching can lead to the enhancement of cooperative behavior under the enormous temptation to defect. Moreover, the influence of discounting the relationship between different individuals is also investigated. Meanwhile, the cooperation prevails when the adjustment of friendships mainly depends on the incomes of selected individuals rather than that of their partners. Finally, it is found that too similar population fail to maximize the cooperation and there exists a moderate similarity that can optimize cooperation.

  16. Partner choice, relationship satisfaction, and oral contraception: the congruency hypothesis.

    PubMed

    Roberts, S Craig; Little, Anthony C; Burriss, Robert P; Cobey, Kelly D; Klapilová, Kateřina; Havlíček, Jan; Jones, Benedict C; DeBruine, Lisa; Petrie, Marion

    2014-07-01

    Hormonal fluctuation across the menstrual cycle explains temporal variation in women's judgment of the attractiveness of members of the opposite sex. Use of hormonal contraceptives could therefore influence both initial partner choice and, if contraceptive use subsequently changes, intrapair dynamics. Associations between hormonal contraceptive use and relationship satisfaction may thus be best understood by considering whether current use is congruent with use when relationships formed, rather than by considering current use alone. In the study reported here, we tested this congruency hypothesis in a survey of 365 couples. Controlling for potential confounds (including relationship duration, age, parenthood, and income), we found that congruency in current and previous hormonal contraceptive use, but not current use alone, predicted women's sexual satisfaction with their partners. Congruency was not associated with women's nonsexual satisfaction or with the satisfaction of their male partners. Our results provide empirical support for the congruency hypothesis and suggest that women's sexual satisfaction is influenced by changes in partner preference associated with change in hormonal contraceptive use. PMID:24818612

  17. Adaptive Inferential Feedback Partner Training for Depression: A Pilot Study

    ERIC Educational Resources Information Center

    Dobkin, Roseanne DeFronzo; Allen, Lesley A.; Alloy, Lauren B.; Menza, Matthew; Gara, Michael A.; Panzarella, Catherine

    2007-01-01

    Adaptive inferential feedback (AIF) partner training is a cognitive technique that teaches the friends and family members of depressed patients to respond to the patients' dysfunctional thoughts in a targeted manner. These dysfunctional attributions, which AIF addresses, are a common residual feature of depression amongst remitted patients, and…

  18. Older Adolescents' Positive Attitudes toward Younger Adolescents as Sexual Partners

    ERIC Educational Resources Information Center

    Hegna, Kristinn; Mossige, Svein; Wichstrom, Lars

    2004-01-01

    The prevalence of older adolescents' positive attitudes toward younger sexual partners was investigated through three measures of self-reported hypothetical likelihood of having sex with preadolescents and younger adolescents (LSA), using a school-based cluster sample of 710 Norwegian 18- to 19-year-olds attending nonvocational high schools in…

  19. The Role of Gender in Officially Reported Intimate Partner Abuse

    ERIC Educational Resources Information Center

    Melton, Heather C.; Sillito, Carrie Lefeve

    2012-01-01

    The role of gender in intimate partner abuse (IPA) perpetration and victimization has been debated for the last several decades. Two perspectives have emerged regarding this debate. Researchers from the family violence perspective argue that men and women are violent at near equal rates and call for a reframing of the issue from one of woman…

  20. Community partners as co-teachers in resident continuity clinics.

    PubMed

    Sturm, Lynne A; Shultz, Janet; Kirby, Rebecca; Stelzner, Sarah M

    2011-12-01

    Standard approaches to teaching the management of psychosocial issues in pediatrics--visits to community-based organizations and stand-alone block rotations in developmental-behavioral pediatrics and community pediatrics--neither expose residents to models of interdisciplinary collaboration between faculty preceptors and community providers nor take advantage of the efficacy of learning in continuity clinics. The authors describe their project, developed from an existing Community Pediatrics Training Initiative with long-standing relationships with a domestic violence shelter, a community center for Latino families, and a special needs resource organization for parents. They lay out in detail the project's innovative use of partners from community-based organizations, colocated within pediatric continuity clinics, who teach both residents and faculty about community resources and linkages with multidisciplinary providers. The authors present lessons learned by faculty preceptors, residents, the community partners, and project staff that can guide future applications of this model in other residency training programs. Faculty and residents indicated an increased awareness of available community resources and how linkages can be incorporated into pediatric outpatient visits. Community partners identified keys to successful co-teaching, including readiness to adopt an assertive communication style and frequent presence in the clinics. Project staff recognized the challenges of staff turnover at community-based organizations and the need to choose community partners with expertise that fits the sociodemographic issues of the clinic's patients. PMID:22030765