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Sample records for patients preliminary results

  1. [Thoracoscopic lung lobectomy: preliminary results in pediatric patients].

    PubMed

    Martínez Ferro, Marcelo; Vidaurreta, Santiago; Buela, Enrique; Bignon, Horacio

    2010-04-01

    The objective of the present study consists of revising our initial experience with the use of thoracoscopic surgery for lung resections and their complications. Clinical histories and videos, from patients treated surgically at the Fundación Hospitalaria-Private Children Hospital and CEMIC Universitary Hospital from april 2005 to october 2008, were retrospectivelly estudied. Eleven female and 9 male patients were included. The median surgical time was 150 min (range: 60-270 min). The median time of chest tube permanence was 3 days (range: 2-10 days). Median hospital stay was 15 days (range: 3-29 days). It was concluded that thoracoscopic lung lobectomies are technically feasible and applicable to all paediatric ages; they should be considered as an alternative approach for trained groups. PMID:20467712

  2. Preliminary Results of Bedaquiline as Salvage Therapy for Patients With Nontuberculous Mycobacterial Lung Disease

    PubMed Central

    Wallace, Richard J.; Benwill, Jeana L.; Taskar, Varsha; Brown-Elliott, Barbara A.; Thakkar, Foram; Aksamit, Timothy R.; Griffith, David E.

    2015-01-01

    BACKGROUND: Bedaquiline is an oral antimycobacterial agent belonging to a new class of drugs called diarylquinolines. It has low equivalent minimal inhibitory concentrations for Mycobacterium tuberculosis and nontuberculous mycobacterial (NTM) lung disease, especially Mycobacterium avium complex (MAC) and Mycobacterium abscessus (Mab). Bedaquiline appears to be effective for the treatment of multidrug-resistant TB but has not been tested clinically for NTM disease. METHODS: We describe a case series of off-label use of bedaquiline for treatment failure lung disease caused by MAC or Mab. Only patients whose insurance would pay for the drug were included. Fifteen adult patients were selected, but only 10 (six MAC, four Mab) could obtain bedaquiline. The 10 patients had been treated for 1 to 8 years, and all were on treatment at the start of bedaquiline therapy. Eighty percent had macrolide-resistant isolates (eight of 10). The patients were treated with the same bedaquiline dosage as that used in TB trials and received the best available companion drugs (mean, 5.0 drugs). All patients completed 6 months of therapy and remain on bedaquiline. RESULTS: Common side effects included nausea (60%), arthralgias (40%), and anorexia and subjective fever (30%). No abnormal ECG findings were observed with a mean corrected QT interval lengthening of 2.4 milliseconds at 6 months. After 6 months of therapy, 60% of patients (six of 10) had a microbiologic response, with 50% (five of 10) having one or more negative cultures. CONCLUSIONS: This small preliminary report demonstrates potential clinical and microbiologic activity of bedaquiline in patients with advanced MAC or Mab lung disease but the findings require confirmation with larger studies. PMID:25675393

  3. Prostatic Artery Embolization as a Primary Treatment for Benign Prostatic Hyperplasia: Preliminary Results in Two Patients

    SciTech Connect

    Carnevale, Francisco Cesar; Antunes, Alberto Azoubel; Motta Leal Filho, Joaquim Mauricio da; Oliveira Cerri, Luciana Mendes de; Baroni, Ronaldo Hueb; Marcelino, Antonio Sergio Zafred; Freire, Geraldo Campos; Moreira, Airton Mota; Srougi, Miguel; Cerri, Giovanni Guido

    2010-04-15

    Symptomatic benign prostatic hyperplasia (BPH) typically occurs in the sixth and seventh decades, and the most frequent obstructive urinary symptoms are hesitancy, decreased urinary stream, sensation of incomplete emptying, nocturia, frequency, and urgency. Various medications, specifically 5-{alpha}-reductase inhibitors and selective {alpha}-blockers, can decrease the severity of the symptoms secondary to BPH, but prostatectomy is still considered to be the traditional method of management. We report the preliminary results for two patients with acute urinary retention due to BPH, successfully treated by prostate artery embolization (PAE). The patients were investigated using the International Prostate Symptom Score, by digital rectal examination, urodynamic testing, prostate biopsy, transrectal ultrasound (US), and magnetic resonance imaging (MRI). Uroflowmetry and postvoid residual urine volume complemented the investigation at 30, 90, and 180 days after PAE. The procedure was performed under local anesthesia; embolization of the prostate arteries was performed with a microcatheter and 300- to 500-{mu}m microspheres using complete stasis as the end point. One patient was subjected to bilateral PAE and the other to unilateral PAE; they urinated spontaneously after removal of the urethral catheter, 15 and 10 days after the procedure, respectively. At 6-month follow-up, US and MRI revealed a prostate reduction of 39.7% and 47.8%, respectively, for the bilateral PAE and 25.5 and 27.8%, respectively, for the patient submitted to unilateral PAE. The early results, at 6-month follow-up, for the two patients with BPH show a promising potential alternative for treatment with PAE.

  4. Preliminary results from the vector therapy in patients with chronic adult periodontitis.

    PubMed

    Vladimirov, S B; Firkova, E I

    2001-01-01

    Complete removal of the dental plaque, dental calculus, granulation tissue and necrotic cement from periodontal pockets is of paramount importance for the proper functioning of the regeneration process in the affected periodontium. The purpose of the current study was to obtain preliminary results of the administered vector therapy in patients with chronic periodontitis. Ten patients with 124 multiple-root and 120 single-root teeth were studied; 600 and 480 root surfaces, respectively, were treated. At each appointment we evaluated the oral hygiene of the patient, the presence of plaque-retention zones, bleeding, suppuration, recession, mobility, the probing depth, the quantity and pH of the crevicular liquid, presence of hyperesthesia. After the initial treatment of the root surfaces abrupt improvement of the clinical condition was observed. One month after the therapy there was reduction of the probing depth and the mobility of teeth, less plaque and less bleeding, decreased retention indices, as well as decrease in the crevicular liquid. PMID:15354463

  5. Long-term monitoring of sleep apnea at home in heart failure patients: preliminary results from the HHH study.

    PubMed

    Pinna, G D; Maestri, R; Gobbi, E; Capomolla, S; Campana, C; Emdin, M; Di Lenarda, A; La Rovere, M T; Andrews, D; Johnson, P; Mortara, A; Sleight, P

    2004-01-01

    Sleep apnea is very common in patients with chronic heart failure (CHF) and has important implications in terms of morbidity, mortality and clinical management. Home respiratory telemonitoring might constitute a potential low-cost, widely-applicable alternative to traditional polysomnography in the evaluation and long-term monitoring of breathing disorders in these patients. In this paper we briefly describe the technological infrastructure and present preliminary results of the European Community multicountry trial HHH (Home or Hospital in Heart Failure), which is currently testing a novel system for home telemonitoring of cardiorespiratory signals in CHF patients. The recording and transmitting devices are suitable to be self-managed by the patient. We give a detailed report on the prevalence of nocturnal respiratory disorders at the beginning of the one-year follow-up and on their persistency over the following recordings (one per month). These preliminary findings clearly indicate that intermittent home telemonitoring of respiratory signals based on patient's self-management is feasible in CHF patients and the compliance is high. Reported statistics unambiguously confirm the high prevalence of nocturnal breathing disorders in these patients and clearly show that this phenomenon tends to persist over time. PMID:17271142

  6. 6-Month Results of Transdiscal Biacuplasty on Patients with Discogenic Low Back Pain: Preliminary Findings

    PubMed Central

    Karaman, Haktan; Tüfek, Adnan; Kavak, Gönül Ölmez; Kaya, Sedat; Yildirim, Zeynep Baysal; Uysal, Ersin; Çelik, Feyzi

    2011-01-01

    Study Design: Prospective observational study. Objective: Our aim is to investigate the efficacy and safety of TransDiscal Biacuplasty. Summary of Background Data: Chronic discogenic pain is one of the leading causes of low back pain; however, the condition is not helped by most non-invasive methods. The results of major surgical operations for these patients are unsatisfactory. Recently, attention has shifted to disk heating methods for treatment. TransDiscal Biacuplasty is one of the minimally invasive treatment methods. The method was developed as an alternative to spinal surgical practices and Intradiscal Electrothermal Therapy for treatment of patients with chronic discogenic pain. Methods: The candidates for this study were patients with chronic discogenic pain that did not respond to conservative treatment. The main criteria for inclusion were: the existence of axial low back pain present for 6 months; disc degeneration or internal disc disruption at a minimum of one level, and maximum of two levels, in MR imaging; and positive discography. Physical function was assessed using the Oswestry Disability Index when measuring the pain with VAS. Patient satisfaction was evaluated using a 4-grade scale. Follow-ups were made 1, 3, and 6 months after treatment. Results: 15 patients were treated at one or two levels. The mean patient age was 43.1±9.2 years. We found the mean symptom duration to be 40.5±45.7 months. At the sixth month, 57.1% of patients reported a 50% or more reduction in pain, while 78.6% of patients reported a reduction of at least two points in their VAS values. In the final check, 78.6% of patients reported a 10-point improvement in their Oswestry Disability scores compared to the initial values. No complications were observed in any of the patients. Conclusions: TransDiscal Biacuplasty is an effective and safe method. PMID:21197258

  7. Laparoscopic gastroplasty. Technique and preliminary results in patients with morbid obesity.

    PubMed

    Awad, W; Loehnert, R

    1997-10-01

    Morbid obesity is an aesthetic, social and psychological problem, with characteristic morbidity and mortality. Surgical treatment has been developed due to the high failure rate of medical treatment. In our previous experience with 40 patients, open transverse gastroplasty reinforced with mesh, has been found to be a good procedure to deal with this problem, with very few postoperative complications. In March 1995 we started a prospective study to evaluate the feasibility and results of the same technique done laparoscopically. We operated on 10 morbid obesity patients with several failed medical treatments. Laparoscopic surgery was felt to be easier and faster than the open technique. Weight loss was similar to that in our previous patients with open surgery, but postoperative pain and complications were less frequent, and the aesthetic results were better. More patients and a longer follow-up will be needed to provide definitive conclusions. PMID:9401432

  8. Trajectory planning method for reduced patient risk in image-guided neurosurgery: concept and preliminary results

    NASA Astrophysics Data System (ADS)

    Shamir, Reuben R.; Joskowicz, Leo; Antiga, Luca; Foroni, Roberto I.; Shoshan, Yigal

    2010-02-01

    We present a new preoperative planning method to quantify and help reduce the risk associated with needle and tool insertion trajectories in image-guided keyhole neurosurgery. The goal is to quantify the risk of a proposed straight trajectory, and/or to find the trajectory with the lowest risk to nearby brain structures based on pre-operative CT/MRI images. The method automatically computes the risk associated with a given trajectory, or finds the trajectory with the lowest risk to nearby brain structures based on preoperative image segmentation and on a risk volume map. The surgeon can revise the suggested trajectory, add a new one using interactive 3D visualization, and obtain a quantitative risk measure. The trajectory risk is evaluated based on the tool placement uncertainty, on the proximity of critical brain structures, and on a predefined table of quantitative geometric risk measures. Our preliminary results on a clinical dataset with eight targets show a significant reduction in trajectory risk and a shortening of the preoperative planning time as compared to the conventional method.

  9. Preliminary speech recognition results after cochlear implantation in patients with unilateral hearing loss: a case series

    PubMed Central

    2011-01-01

    Introduction Cochlear implants known to provide support in individuals with bilateral hearing loss may also be of great benefit for individuals with unilateral hearing loss. This case report demonstrates the positive effects of cochlear implantation on speech understanding in noise conditions in patients with unilateral hearing loss and normal hearing on the contralateral side. To the best of our knowledge, the data presented here are from the first few cases to receive a cochlear implant for unilateral hearing loss. Case presentation Four Caucasian German men, two aged 48 and the others aged 51 and 57 years old, with post-lingual unilateral hearing loss and normal hearing on the contralateral side were implanted with a cochlear implant. All our patients were members of the German army. Before and after implantation, they were given a battery of speech tests in different hearing conditions to assess the effect of unilateral cochlear implantation on speech understanding in noise conditions. Test results showed that all patients benefited from unilateral cochlear implantation, particularly in terms of speech understanding in noise conditions. Conclusions Unilateral cochlear implantation might be a successful treatment method for patients with unilateral hearing loss not benefiting from alternative treatment options. The results of this case report open up the field of cochlear implantation for expanded criteria and new areas of research. PMID:21810235

  10. Involvement of IL-23 in enteropathic arthritis patients with inflammatory bowel disease: preliminary results.

    PubMed

    Gheita, Tamer A; El Gazzar, Iman I; El-Fishawy, Hussein S; Aboul-Ezz, Mohamed A; Kenawy, Sanaa A

    2014-05-01

    The role of interleukin (IL)-23 in the pathogenesis of inflammatory bowel disease (IBD) remains unclear. The aim of this work was to study the serum level of IL-23 in IBD with and without arthritis and determine its relation to the subsets and clinical features of the disease. Thirty-seven patients with IBD including 11 with arthritis were included in the study with a mean age of 30.86 ± 4.66 years. Twenty healthy subjects served as control. Seronegative spondyloarthropathy was present in 11 (29.73 %) of the IBD patients; Crohn's disease (CD) was present in 23 and 14 had ulcerative colitis (UC). Serum level of IL-23 was measured in all patients and control by ELISA. IL-23 was significantly higher in IBD patients (46.24 ± 27.19 pg/ml) compared to control (24.1 ± 2.31 pg/ml) (p < 0.0001) being higher in CD patients (52.57 ± 32.78 pg/ml) compared to those with UC (35.86 ± 6.41 pg/ml) (p = 0.026). Furthermore, it was significantly higher in those with peripheral and/or axial arthritis (67.73 ± 40.85 pg/ml) compared to patients without (37.15 ± 10.37 pg/ml) (p = 0.03). There was a tendency to a higher level in males (49.15 ± 30.97 pg/ml) compared to females (38.4 ± 9.54 pg/ml). Serum IL-23 is increased in IBD especially those with CD associated with arthritis and sacroiliitis. The IL-23 could be added to the biomarkers of development of arthritis in IBD patients. These results also confirm the findings of previous studies on the critical role played by IL-23 in the pathogenesis of IBD making it an important new therapeutic target for these patients. PMID:24384828

  11. Laparoscopic Treatment of Ventral Abdominal Wall Hernias: Preliminary Results in 100 Patients

    PubMed Central

    Martín del Olmo, Juan Carlos; Blanco, Jose Ignacio; de la Cuesta, Carmen; Martín, Fernando; Toledano, Miguel; Perna, Christiam; Vaquero, Carlos

    2000-01-01

    Objective: The laparoscopic treatment of eventrations and ventral hernias has been little used, although these hernias are well suited to a laparoscopic approach. The objective of this study was to investigate the usefulness of a laparoscopic approach in the surgical treatment of ventral hernias. Methods: Between January 1994 and July 1998, a series of 100 patients suffering from major abdominal wall defects were operated on by means of laparoscopic techniques, with a mean postoperative follow-up of 30 months. The mean number of defects was 2.7 per patient, the wall defect was 93 cm2 on average. There were 10 minor hernias (<5 cm), 52 medium-size hernias (5-10 cm), and 38 large hernia (>10 cm). The origin of the wall defect was primary in 21 cases and postsurgical in 79. Three access ports were used, and the defects were covered with PTFE Dual Mesh measuring 19 × 15 cm in 54 cases, 10 x 15 cm in 36 cases, and 12 × 8 cm in 10 cases. An additional mesh had to be added in 21 cases. In the last 30 cases, PTFE Dual Mesh Plus with holes was employed. Results: Average surgery time was 62 minutes. One procedure was converted to open surgery, and only one patient required a second operation in the early postoperative period. Minor complications included 2 patients with abdominal wall edema, 10 seromas, and 3 subcutaneous hematomas. There were no trocar site infections. Two patients developed hernia relapse (2%) in the first month after surgery and were reoperated with a similar laparoscopic technique. Oral intake and mobilization began a few hours after surgery. The mean stay in hospital was 28 hours. Conclusions: Laparoscopic technique makes it possible to avoid large incisions, the placement of drains, and produces a lower number of seromas, infections and relapses. Laparoscopic access considerably shortens the time spent in the hospital. PMID:10917121

  12. Determinants of eligibility and use of ehealth for cardiac rehabilitation patients: preliminary results.

    PubMed

    Wiggers, Anne-Marieke; Peek, Niels; Kraaijenhagen, Roderik; Jaspers, Monique

    2014-01-01

    To foster implementation of eHealth in care practice, it is important to gain insight into the factors that influence acceptance. The aim of this study was to identify determinants of eligibility and use for completing an electronic needs assessment for cardiac rehabilitation. We analysed the influence of age, gender, diagnosis, health literacy, quality of life scores, and depression and anxiety scores. Among 240 patients entering CR in two clinics, 101 patients were deemed eligible to use the system by their CR professional, of which 75 (74.2%) actually used it. Only 50% of the patients who had an acute coronary syndrome and 20% of the patients with chronic heart failure were deemed eligible. Furthermore, there was a decreasing trend towards usage in female patients, patients with symptoms of anxiety, and patients with a better quality of life. In the future we will continue to explore barriers and success factors as experienced by the patients and the participating clinics to optimize the system. PMID:25160301

  13. Home Palliative Care for Patients with Advanced Chronic Kidney Disease: Preliminary Results

    PubMed Central

    Teruel, José L.; Rexach, Lourdes; Burguera, Victor; Gomis, Antonio; Fernandez-Lucas, Milagros; Rivera, Maite; Diaz, Alicia; Collazo, Sergio; Liaño, Fernando

    2015-01-01

    Healthcare for patients with advanced chronic kidney disease (ACKD) on conservative treatment very often poses healthcare problems that are difficult to solve. At the end of 2011, we began a program based on the care and monitoring of these patients by Primary Care Teams. ACKD patients who opted for conservative treatment were offered the chance to be cared for mainly at home by the Primary Care doctor and nurse, under the coordination of the Palliative Care Unit and the Nephrology Department. During 2012, 2013, and 2014, 76 patients received treatment in this program (mean age: 81 years; mean Charlson age-comorbidity index: 10, and mean glomerular filtration rate: 12.4 mL/min/1.73 m2). The median patient follow-up time (until death or until 31 December 2014) was 165 days. During this period, 51% of patients did not have to visit the hospital’s emergency department and 58% did not require hospitalization. Forty-eight of the 76 patients died after a median time of 135 days in the program; 24 (50%) died at home. Our experience indicates that with the support of the Palliative Care Unit and the Nephrology Department, ACKD patients who are not dialysis candidates may be monitored at home by Primary Care Teams. PMID:27417813

  14. Preliminary Results of Whole Brain Radiotherapy With Concurrent Trastuzumab for Treatment of Brain Metastases in Breast Cancer Patients

    SciTech Connect

    Chargari, Cyrus; Idrissi, Hind Riahi; Pierga, Jean-Yves; Bollet, Marc A.; Dieras, Veronique; Campana, Francois; Cottu, Paul; Fourquet, Alain; Kirova, Youlia M.

    2011-11-01

    Purpose: To assess the use of trastuzumab concurrently with whole brain radiotherapy (WBRT) for patients with brain metastases from human epidermal growth factor receptor-2-positive breast cancer. Methods and Materials: Between April 2001 and April 2007, 31 patients with brain metastases from human epidermal growth factor receptor-2-positive breast cancer were referred for WBRT with concurrent trastuzumab. At brain progression, the median age was 55 years (range, 38-73), and all patients had a performance status of 0-2. The patients received trastuzumab 2 mg/kg weekly (n = 17) or 6 mg/kg repeated every 21 days (n = 14). In 26 patients, concurrent WBRT delivered 30 Gy in 10 daily fractions. In 6 patients, other fractionations were chosen because of either poor performance status or patient convenience. Results: After WBRT, radiologic responses were observed in 23 patients (74.2%), including 6 (19.4%) with a complete radiologic response and 17 (54.8%) with a partial radiologic response. Clinical responses were observed in 27 patients (87.1%). The median survival time from the start of WBRT was 18 months (range, 2-65). The median interval to brain progression was 10.5 months (range, 2-27). No Grade 2 or greater acute toxicity was observed. Conclusion: The low toxicity of trastuzumab concurrently with WBRT should probably not justify delays. Although promising, these preliminary data warrant additional validation of trastuzumab as a potential radiosensitizer for WBRT in brain metastases from breast cancer in the setting of a clinical trial.

  15. The use of relaxation techniques in the perioperative management of proctological patients: preliminary results.

    PubMed

    Renzi, C; Peticca, L; Pescatori, M

    2000-11-01

    Relaxation techniques positively affect the psychosomatic pattern of patients undergoing surgical treatment. Among these techniques guided imaging (GI) has been reported to improve outcome following colorectal surgery. This study assessed the effects of GI on the postoperative course in proctological patients. We carried out a prospective randomized trial in a group of patients operated on for anorectal diseases in our coloproctology unit. Patients were randomized into group 1 (n = 43) with standard care and group 2 (n = 43) with relaxation techniques; they listened to a GI tape with music and relaxing text before, during, and after surgery. The following parameters were evaluated by a questionnaire (a) postoperative pain measured by visual analogue score, (b) the quality of sleep measured by a similar score, and (c) the nature of first micturition, evaluated as normal or difficult. Groups were similar in age and sex distribution, type of disease, and operation performed. The pain score was 3.2 +/- 1.4 in GI patients and 4.1 +/- 2.1 in controls (P = 0.07). The quality of sleep score was 4.8 +/- 2.9 in GI patients and 6.4 +/- 2.7 in controls (P = 0.01). The first micturition was painful in 10.3% of GI patients and in 27.3% of controls (P = 0.09). Perioperative relaxation techniques thus showed a trend to reducing pain following anorectal surgery and significantly improving the quality of sleep; a decrease in anxiety and a consequent muscle relaxation may be involved. Therefore GI, a low cost and noninvasive procedure, can be recommended as an helpful tool in this type of surgery. PMID:11151436

  16. Laparoscopic highly selective vagotomy: technical considerations and preliminary results in 119 patients with duodenal ulcer or gastroesophageal reflux disease.

    PubMed

    Awad, W; Csendes, A; Braghetto, I; Yarmuch, J; Loehnert, R; Burdiles, P; Diaz, J C; Schutte, H; Maluenda, F

    1997-01-01

    The technical considerations and preliminary results of 119 patients submitted to laparoscopic highly selective vagotomy are presented. There were 33 with duodenal ulcers, 31 with duodenal ulcers plus gastroesophageal reflux, and 55 with gastroesophageal reflux. Operating time varied from 120 to 160 minutes. Six complications occurred: four perforations of the gastric fundus and two bleeding episodes. Conversion to open surgery was done in four cases and reoperation in one case. No deaths occurred, and the mean hospital stay was 3 days. The mean follow-up was 16 months, being 94% of the cases with Visick I or II and 6% with Visick III or IV. This technique is completely feasible by laparoscopic procedure and reproduces exactly what has been done with the laparotomy approach. PMID:9015168

  17. A Study of the Relationship between Child Abuse and Drug Addiction in 178 Patients: Preliminary Results.

    ERIC Educational Resources Information Center

    Cohen, Frederick S.; Densen-Gerber, Judianne

    1982-01-01

    A questionnaire on family intactness, parental and sibling relationships, and personal physical/sexual abuse histories was completed by 178 adults in treatment for drug/alcohol addiction. Results revealed that 84 percent of the sample reported a history of child abuse/neglect. (Author/CL)

  18. Can homeopathy bring additional benefits to thalassemic patients on hydroxyurea therapy? Encouraging results of a preliminary study.

    PubMed

    Banerjee, Antara; Chakrabarty, Sudipa Basu; Karmakar, Susanta Roy; Chakrabarty, Amit; Biswas, Surjyo Jyoti; Haque, Saiful; Das, Debarsi; Paul, Saili; Mandal, Biswapati; Naoual, Boujedaini; Belon, Philippe; Khuda-Bukhsh, Anisur Rahman

    2010-03-01

    Several homeopathic remedies, namely, Pulsatilla Nigricans (30th potency), Ceanothus Americanus (both mother tincture and 6th potency) and Ferrum Metallicum (30th potency) selected as per similia principles were administered to 38 thalassemic patients receiving Hydroxyurea (HU) therapy for a varying period of time. Levels of serum ferritin (SF), fetal hemoglobin (HbF), hemoglobin (Hb), platelet count (PC), mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), mean corpuscular hemoglobin (MCH), white blood cell (WBC) count, bilirubin content, alanine amino transferase (ALT), aspartate amino transferase (AST) and serum total protein content of patients were determined before and 3 months after administration of the homeopathic remedies in combination with HU to evaluate additional benefits, if any, derived by the homeopathic remedies, by comparing the data with those of 38 subjects receiving only HU therapy. Preliminary results indicated that there was a significant decrease in the SF and increase in HbF levels in the combined, treated subjects. Although the changes in other parameters were not so significant, there was a significant decrease in size of spleen in most patients with spleenomegaly and improvement in general health conditions along with an increased gap between transfusions in most patients receiving the combined homeopathic treatment. The homeopathic remedies being inexpensive and without any known side-effects seem to have great potentials in bringing additional benefits to thalassemic patients; particularly in the developing world where blood transfusions suffer from inadequate screening and fall short of the stringent safety standards followed in the developed countries. Further independent studies are encouraged. PMID:18955271

  19. Intersphincteric anal lipofilling with micro-fragmented fat tissue for the treatment of faecal incontinence: preliminary results of three patients

    PubMed Central

    De Rosa, Michele; Massa, Salvatore; Amato, Bruno; Gentile, Maurizio

    2014-01-01

    Faecal incontinence is a very debilitating problem. Many techniques have been proposed to treat this condition, with controversial results. Autologous transplant of fat tissue is an established procedure used for the repair of tissue damage, and recent studies revealed the potentiality of tissue regeneration by human adipose-derived stem cells. We treated this condition with the injection, in the intersphincteric anal groove, of lipoaspirate processed by an innovative technology (Lipogems). The aim of the study was to evaluate the efficacy of Lipogems injection for the treatment of faecal incontinence. In February 2014 we treated 3 patients with faecal incontinence. The surgical procedure required three phases: lipoaspiration, processing of lipoaspirate with the Lipogems system, and injection of the obtained product in the intersphincteric anal groove. An accurate proctological examination followed at 1 week, 1 month and 6 months after treatment. Each patient reported an improved Wexner incontinence score at 1 month after the procedure. We observed an increase of resting pressure (by at least 10 mm Hg) and thickness of the internal anal sphincter respectively at ano-rectal manometry and by ultrasound (US) evaluation at the sixth month of follow-up. Our preliminary results are encouraging, but multicentric studies with longer follow-up are needed to validate this novel technique for treatment of faecal incontinence. PMID:26240640

  20. Preliminary results in surgery of Parkinson's disease.

    PubMed

    Nasser, J A; Confort, C I; Ferraz, A; Bouza, A A

    1998-09-01

    The authors present the preliminary results of 20 patients selected to be operated on between January 1996 and April 1997. These patients presented one of the present indications for stereotactic posteroventral pallidotomy (PVP), such as: rigidity, akinesia/bradykinesia, gait dysfunction, drug induced dyskinesias and tremor. Every patient of this protocol was evaluated by: UPDRS score, Schwab and England scale, Hoehn and Yahr Staging Scale before and after surgery. The results in 3 months showed a remarkable improvement after PVP (P < 0.01) in all functional assessments, except for facial expression, speech and posture. The morbidity was 5%. 5 patients (25%) who were in Hoehn and Yahr 5 underwent a bilateral simultaneous PVP. In 5 patients (25%), who had tremor, during the PVP, VIM thalamotomy was added. These preliminary results, suggest that PVP is highly effective for PD symptoms. PMID:9850746

  1. Surveyor 3 Preliminary Science Results

    NASA Technical Reports Server (NTRS)

    1967-01-01

    Surveyor III soft-landed on the Moon at 00:04 GMT on April 20, 1967. Data obtained have significantly increased our knowledge of the Moon. The Surveyor III spacecraft was similar to Surveyor I; the only major change in scientific instrumentation was the addition of a soil mechanics surface sampler. Surveyor III results at this preliminary evaluation of data give valuable information about the relation between the surface skin of under-dense material responsible for the photometric properties and the deeper layers of material whose properties resemble those of ordinary terrestrial soils. In addition, they provide new insight into the relation between the general lunar surface as seen by Surveyor I and the interior of a large subdued crater. The new results have also contributed to our understanding of the mechanism of downhill transport. Many critical questions cannot, however, be answered until final reduction of experimental data.

  2. Preliminary Results of the Analysis

    NASA Technical Reports Server (NTRS)

    Pap, Judit

    1995-01-01

    The preliminary results of the photometry of CaII K spectroheliograms taken at the NationalSolar Observatory at Sacramento peak are presented in this paper. We have digitizedspectroheliograms for 1980 (maximum of SC21), 1985 (minimum of SC21), 1987 (beginning of theascending phase of SC22), 1988 and 1989 (ascending phase and maximum of SC22), and 1992(declining phase of SC22). We have analyzed images for 1992 and separated the plages, the magneticnetwork, internetwork elements and the chromospheric background using histogram method. Wehave derived the intensity and area of these features as well as the full disk intensity (Spatial KIndex). The Spatial K Index has been compared to the spectral Ca K index derived from the lineprofiles and total solar and UV irradiance measured by the UARS and NOAA9 satellites. Thecontribution of plages, the magnetic network and internetwork element to the changes observed intotal solar and UV irradiances are also estimated.

  3. Monsoon '90 - Preliminary SAR results

    NASA Technical Reports Server (NTRS)

    Dubois, Pascale C.; Van Zyl, Jakob J.; Guerra, Abel G.

    1992-01-01

    Multifrequency polarimetric synthetic aperture radar (SAR) images of the Walnut Gulch watershed near Tombstone, Arizona were acquired on 28 Mar. 1990 and on 1 Aug. 1990. Trihedral corner reflectors were deployed prior to both overflights to allow calibration of the two SAR data sets. During both overflights, gravimetric soil moisture and dielectric constant measurements were made. Detailed vegetation height, density, and water content measurements were made as part of the Monsoon 1990 Experiment. Preliminary results based on analysis of the multitemporal polarimetric SAR data are presented. Only the C-band data (5.7-cm wavelength) radar images show significant difference between Mar. and Aug., with the strongest difference observed in the HV images. Based on the radar data analysis and the in situ measurements, we conclude that these differences are mainly due to changes in the vegetation and not due to the soil moisture changes.

  4. Monsoon 1990: Preliminary SAR results

    NASA Technical Reports Server (NTRS)

    Vanzyl, Jakob J.; Dubois, Pascale; Guerra, Abel

    1991-01-01

    Multifrequency polarimetric synthetic aperture radar (SAR) images of the Walnut Gulch watershed near Tombstone, Arizona were acquired on 28 Mar. 1990 and on 1 Aug. 1990. Trihedral corner reflectors were deployed prior to both overflights to allow calibration of the two SAR data sets. During both overflights, gravimetric soil moisture and dielectric constant measurements were made. Detailed vegetation height, density, and water content measurements were made as part of the Monsoon 1990 Experiment. Preliminary results based on analysis of the multitemporal polarimetric SAR data are presented. Only the C-band data (5.7-cm wavelength) radar images show significant difference between Mar. and Aug., with the strongest difference observed in the HV images. Based on the radar data analysis and the in situ measurements, we conclude that these differences are mainly due to changes in the vegetation and not due to the soil moisture changes.

  5. Online counseling via e-mail for breast cancer patients on the German internet: preliminary results of a psychoeducational intervention

    PubMed Central

    David, Niklas; Schlenker, Peter; Prudlo, Uwe; Larbig, Wolfgang

    2011-01-01

    Objectives: The internet offers new possibilities in psychosocial patient care. However, empirical data are lacking for oncological patients. A field-experimental study was conducted to obtain initial data to enable evaluation of the effectiveness of online counseling via e-mail for breast cancer patients. A secondary objective was to explore how patients reached by the service can be characterized on psychosocial status and illness. Methods: On a dedicated German-language website, 235 breast cancer patients registered for psychosocial counseling via e-mail. 133 registrants were randomly assigned to a treatment group to receive immediate counseling or to a waiting list control group. The two-month counseling session took the form of a psychoeducation, individually tailored to each patient. Psychosocial outcome measures including psychological distress (BSI) and quality of life (EORTC QLQ-C30) were assessed at registration and at a two-month follow-up. Descriptive data were recorded at registration. At the conclusion of the program, participants were asked to complete a patient satisfaction questionnaire (ZUF-8). Results: BSI responses showed that 85% of all patients were initially diagnosable with comorbid psychopathology. Despite high severity of distress and attendant large reductions in quality of life, 72% of all patients were not obtaining conventional assistance. Among counseling participants (n=31), no significant improvements in distress or quality of life were found in comparison to the control group (n=34), but patient satisfaction was nonetheless high. Conclusion: The study demonstrates that online counseling via e-mail reaches patients with unmet therapeutic needs, but also indicated its limitations, suggesting that the online setting may be most useful for prompting and supporting a transition to conventional counseling services. PMID:21922032

  6. Postoperative survival for patients with thymoma complicating myasthenia gravis—preliminary retrospective results of the ChART database

    PubMed Central

    Wang, Fangrui; Fu, Jianhua; Shen, Yi; Wei, Yucheng; Tan, Lijie; Zhang, Peng; Han, Yongtao; Chen, Chun; Zhang, Renquan; Li, Yin; Chen, Keneng; Chen, Hezhong; Liu, Yongyu; Cui, Youbing; Wang, Yun; Yu, Zhentao; Zhou, Xinming; Liu, Yangchun; Liu, Yuan; Gu, Zhitao

    2016-01-01

    Background It is so far not clear that how myasthenia gravis (MG) affected the prognosis of thymoma patients. The aim of this assay is to compare the postoperative survival between patients with thymoma only and those with both thymoma and MG. Methods The Chinese Alliance for Research in Thymomas (ChART) registry recruited patients with thymoma from 18 centers over the country on an intention to treat basis from 1992 to 2012. Two groups were formed according to whether the patient complicated MG. Demographic and clinical data were reviewed, patients were followed and their survival status were analyzed. Results There were 1,850 patients included in this study, including 421 with and 1,429 without MG. Complete thymectomy were done in 91.2% patients in MG group and 71.0% in non-MG group (P<0.05). There were more percentage of patients with the histology of thymoma AB, B1, or B2 (P<0.05) in MG group, and more percentage of patients with MG were in Masaoka stage I and II. The 5- and 10-year overall survival (OS) rates were both higher in MG group (93% vs. 88%; 83% vs. 81%, P=0.034) respectively. The survival rate was significantly higher in patients with MG when the Masaoka staging was 3/4 (P=0.003). Among patients with advanced stage thymoma (stage 3, 4a, 4b), the constituent ratios of 3, 4a, 4b were similar between MG and non-MG group. Histologically, however, there were significantly more proportion of AB/B1/B2/B3 in the MG group while there were more C in the non-MG group (P=0.000). Univariate analyses for all patients showed that MG, WHO classification, Masaoka stage, surgical approach, chemotherapy and radiotherapy and resectability were significant factors, and multivariate analysis showed WHO classification, Masaoka stage, and resectability were strong independent prognostic indicators. Conclusions Although MG is not an independent prognostic factor, the survival of patients with thymoma was superior when MG was present, especially in late Masaoka stage

  7. Quality of life in colon cancer patients with skin side effects: preliminary results from a monocentric cross sectional study

    PubMed Central

    2010-01-01

    Background Epidermal growth factor receptor inhibitors are widely prescribed anticancer drugs. Patients treated commonly develop dermatologic adverse drugs reactions, but rarely they are involved in systematic evaluation of their quality of life. This monocentric cross sectional study is carried out to assess quality of life in colon cancer patients experienced skin side effects due to anti epidermal growth factor receptor inhibitors therapy. Methods Consecutive patients with skin side effects to therapy treated at Fondazione Poliambulanza were enrolled in this study. Quality of life was evaluated with the Italian validated version of Skindex-29 questionnaire, exploring three dimensions: symptoms, emotional, and physical functioning. Skindex-29 was administered one time between the eighth and the twelfth week of the treatment. Results Forty-five consecutive patients, mainly with metastatic colon cancer (29 female, 16 male), with an average age of 59.31 years (ranging from 34-78) were included in the study and analyzed. Patients showed a great impact of skin side effects on symptoms (mean 43), followed by emotional (mean 30), and functioning (mean 26) scales. In general women, the 55-65 age class, and patients with partial remission reported the worst quality of life. Conclusions Epidermal growth factor receptor inhibitors' skin side effects have an important impact on quality of life in advanced colon cancer patients; symptoms scale is the most effect respect to emotional and functioning scales. PMID:20398332

  8. Successful hepatitis B vaccination in patients who underwent transplantation for hepatitis B virus-related cirrhosis: preliminary results.

    PubMed

    Bienzle, Ulrich; Günther, Matthias; Neuhaus, Ruth; Neuhaus, Peter

    2002-06-01

    Long-term hepatitis B immunoglobulin (HBIg) prophylaxis prevents endogenous hepatitis B virus (HBV) reinfection in the majority of liver transplant recipients. Active hepatitis B vaccination after orthotopic liver transplantation (OLT) in these patients has produced conflicting results to date. On this study, patients who remained hepatitis B surface antigen (HBsAg) negative with passive immunization after OLT for HBV cirrhosis were actively immunized using recombinant HBV antigen (Engerix), together with a novel adjuvant system (monophosphoryl lipid A and a natural saponine molecule). This led to a sustained antibody response to HBsAg (>500 IU/L) in 5 of 10 patients. This antibody response prevented reinfection and allowed termination of prophylactic HBIg substitution for more than 12 months in these patients. PMID:12037789

  9. EUPORIAS: plans and preliminary results

    NASA Astrophysics Data System (ADS)

    Buontempo, C.

    2013-12-01

    Recent advances in our understanding and ability to forecast climate variability have meant that skilful predictions are beginning to be routinely made on seasonal to decadal (s2d) timescales. Such forecasts have the potential to be of great value to a wide range of decision-making, where outcomes are strongly influenced by variations in the climate. In 2012 the European Commission funded EUPORIAS, a four year long project to develop prototype end-to-end climate impact prediction services operating on a seasonal to decadal timescale, and assess their value in informing decision-making. EUPORIAS commenced on 1 November 2012, coordinated by the UK Met Office leading a consortium of 24 organisations representing world-class European climate research and climate service centres, expertise in impacts assessments and seasonal predictions, two United Nations agencies, specialists in new media, and commercial companies in climate-vulnerable sectors such as energy, water and tourism. The poster describes the setup of the project, its main outcome and some of the very preliminary results.

  10. 1.9-um diode-laser-assisted anastomoses in reconstructive microsurgery: preliminary results in 12 patients

    NASA Astrophysics Data System (ADS)

    Mordon, Serge R.; Schoffs, Michel; Martinot, Veronique L.; Buys, Bruno; Patenotre, Philippe; Lesage, Jean C.; Dhelin, Guy

    1998-01-01

    The authors reported an original 1.9 micrometer diode laser assisted microvascular anastomosis (LAMA) in human. This technique has been applied in 12 patients during reconstructive surgery for digital replantations (n equals 2), for digital revascularizations (n equals 3) and for free flap transfers (n equals 7). Fourteen end-to-end anastomoses (10 arteries, 4 veins) were performed. LAMA were always performed on vessel which did not impede the chance of success of the surgical procedure in case of thrombosis. LAMA was performed with a 1.9 micrometer diode laser after placement of 2 equidistant stitches. The didoes spot was obtained by means of an optic fiber transmitted to the vessel wall via a pencil size hand piece. The used parameters were as followed: spot size equals 400 micrometer, power equals 70 to 220 mW, time equals 0.7 to 2 seconds, mean fluence equals 115 J/cm2. The mechanism involved is a thermal effect on the collagen of the adventitia and media leading to a phenomena which the authors have termed 'heliofusion.' This preliminary trial has permitted to define the modalities of its use in human. The technique is simple, rapid and easily learned. The equipment is not cumbersome, sterilizable and very ergonomic. LAMA does not replace sutures but is complementary, thanks to a reduction in the number of stitches used and to an access to surgical areas which are not easily accessible. This study must be completed by a larger scale study to confirm this technique and its reliability. Others uses could performed on different tissues such as biliary and urinary track, specially under laparoscopic conditions.

  11. Impairments in an early stage of the decision-making process in patients with ventromedial prefrontal damage: preliminary results.

    PubMed

    Eggen, Céline; Huber, Oswald; Bär, Arlette; Huber, Odilo W; Perrig, Walter J; Müri, René; Gutbrod, Klemens

    2015-01-01

    Lesions of the ventromedial prefrontal cortex can result in a deficient decision-making behavior. So far, most experimental results in the neuropsychological decision-making research have been obtained with gambling tasks. Due to their high complexity, it is difficult to evaluate the underlying processes of the decision-making deficits. The aim of this study was to assess if patients with ventromedial prefrontal damage compared to patients with dorsolateral prefrontal damage and controls show a deficit in an early stage of the decision-making process. Nine patients with ventromedial prefrontal damage, three with dorsolateral prefrontal damage, and eleven healthy controls were tested with a newly developed decision task in which they had to search actively for the information they needed for their decisions. Our results show that patients with ventromedial prefrontal damage compared to the brain-lesioned dorsolateral prefrontal control group and healthy controls searched less for information with regard to risk defusing operators or consequences of their decisions indicating impairment already in the early stage of the decision-making process. PMID:25080839

  12. Immunomodulatory effects of total intravenous and balanced inhalation anesthesia in patients with bladder cancer undergoing elective radical Cystectomy: preliminary results

    PubMed Central

    2013-01-01

    Background Although surgery and anesthesia induce immunesuppression, remains largely unknown whether various anesthetic techniques have different immunosuppressive effects on cancer patients. Therefore, the aim of this study was to investigate the influence of total intravenous anesthesia with target-controlled infusion (TIVA-TCI) and balanced inhalation anesthesia (BAL) on the peri-operative levels of inflammatory cytokines and regulatory T cells (Tregs) in patients with bladder cancer undergoing surgery. Methods Twenty eight consecutive patients with bladder cancer who underwent radical cystectomy were prospectively randomized into two groups to receive TIVA-TCI (n = 14) or BAL (n = 14). Before the induction of anesthesia (T0), 6–8 hours (T1) post-surgery, and 5 days post-surgery (T2), Tregs and serum levels of interleukin -1beta (IL-1β), interferon-gamma (IFN-γ), tumor necrosis factor-alpha (TNF-α), interleukin −2 (IL-2), interleukin −6 (IL-6), and interleukin −10 (IL-10) were measured. Results In the peri-operative period all cancer patients showed a marked and significant increase in IL-6. Moreover, TIVA-TCI patients also showed a higher increase in IFN-γ, whereas in BAL patients Tregs were reduced by approximately 30% during surgery. The incidence of infections, metastases, and death was similar in both groups. Conclusions The increase in the Th1 response in the TIVA-TCI group and the reduction in Tregs in the BAL group seem to balance the immunosuppressive effect induced by IL-6. Therefore TIVA-TCI and BAL can be both used in major surgery in patients with bladder cancer without worsening the outcome. PMID:23374147

  13. Comparative Soot Diagnostics: Preliminary Results

    NASA Technical Reports Server (NTRS)

    Urban, David L.; Griffin, DeVon W.; Gard, Melissa Y.

    1997-01-01

    detected and suppressed. Prior to CSD, no combustion-generated particulate samples had been collected near the flame zone for well-developed microgravity flames. All of the extant data either came from drop tower tests and therefore only corresponded to the early stages of a fire or were collected far from the flame zone. The fuel sources in the drop tower tests were restricted to laminar gas-jet diffusion flames and very rapidly overheated wire insulation. The gas-jet tests indicated, through thermophoretic sampling, (2) that soot primaries and aggregates (groups of primary particles) in low-gravity may be significantly larger than those in normal gravity (1-g). This raises new scientific questions about soot processes as well as practical issues for particulate size sensitivity and detection alarm threshold levels used in on-orbit smoke detectors. Preliminary tests in the 2.2 second drop tower suggest that particulate generated by overheated wire insulation may be larger in low-g than in 1-g. Transmission Electron Microscope (TEM) grids downstream of the fire region in the Wire Insulation Flammability experiment as well as visual observation of long string-like aggregates, further confirm this suggestion. The combined impact of these limited results and theoretical predictions is that, as opposed to extrapolation from l-g data, direct knowledge of low-g combustion particulate is needed for more confident design of smoke detectors for spacecraft. This paper describes the operation and preliminary results of the CSD, a project conceived and developed at NASA Lewis Research Center. The CSD flight experiment was conducted in the Middeck Glovebox Facility (MGBX) on USMP-3. The project is support by NASA Headquarters Microgravity Science and Applications Division and Code Q. The results presented here are from the microgravity portion of the experiment, including the temporal response of the detectors and average sizes of the primary and aggregate particles captured on the

  14. Preliminary Results of Helical Tomotherapy in Patients with Complex-Shaped Meningiomas Close to the Optic Pathway

    SciTech Connect

    Schiappacasse, Luis Cendales, Ricardo; Sallabanda, Kita; Schnitman, Franco; Samblas, Jose

    2011-01-01

    Meningiomas are the most common benign intracranial tumor. Meningiomas close to the optic pathway represent a treatment challenge both for surgery and radiotherapy. The aim of this article is to describe early results of helical tomotherapy treatment in complex-shaped meningiomas close to the optic pathway. Twenty-eight patients were consecutively treated. All patients were immobilized with a thermoplastic head mask and planned with the aid of a magnetic resonance imaging-computed tomography fusion. All treatments included daily image guidance. Pretreatment symptoms and acute toxicity were recorded. Median age was 57.5 years, and 92.8% patients had Eastern Cooperative Oncology Group performance status scale {<=}1. The most common localizations were the sella turcica, followed by the cavernous sinus and the sphenoid. The most common symptoms were derived from cranial nerve deficits. Tomotherapy was administered as primary treatment in 35.7% of patients, as an adjuvant treatment in 32.4%, and as a rescue treatment after postsurgical progression in 32.1% patients. Most patients were either inoperable or Simpson IV. Total dose varied between 5000 and 5400 cGy; fractionation varied between 180 and 200 cGy. Median dose to the planning target volume was 51.7 Gy (range, 50.2-55.9 Gy). Median coverage index was 0.89 (range, 0.18-0.97). Median homogeneity index was 1.05 (range, 1-1.12). Acute transient toxicity was grade 1 and included headache in 35.7% patients, ocular pain/dryness in 28.5%, and radiation dermatitis in 25%. Thus far, with a maximal follow-up of 3 years, no late effects have been seen and all patients have a radiological stabilization of the disease. Helical tomotherapy offered a safe and effective therapeutic alternative for patients with inoperable or subtotally resected complex-shaped meningiomas close to the optic pathway. Acceptable coverage and homogeneity indexes were achieved with appropriate values for maximal doses delivered to the eyes, lenses

  15. Treatment of macular degeneration using embryonic stem cell-derived retinal pigment epithelium: preliminary results in Asian patients.

    PubMed

    Song, Won Kyung; Park, Kyung-Mi; Kim, Hyun-Ju; Lee, Jae Ho; Choi, Jinjung; Chong, So Young; Shim, Sung Han; Del Priore, Lucian V; Lanza, Robert

    2015-05-12

    Embryonic stem cells hold great promise for various diseases because of their unlimited capacity for self-renewal and ability to differentiate into any cell type in the body. However, despite over 3 decades of research, there have been no reports on the safety and potential efficacy of pluripotent stem cell progeny in Asian patients with any disease. Here, we report the safety and tolerability of subretinal transplantation of human embryonic-stem-cell (hESC)-derived retinal pigment epithelium in four Asian patients: two with dry age-related macular degeneration and two with Stargardt macular dystrophy. They were followed for 1 year. There was no evidence of adverse proliferation, tumorigenicity, ectopic tissue formation, or other serious safety issues related to the transplanted cells. Visual acuity improved 9-19 letters in three patients and remained stable (+1 letter) in one patient. The results confirmed that hESC-derived cells could serve as a potentially safe new source for regenerative medicine. PMID:25937371

  16. Could machine learning improve the prediction of pelvic nodal status of prostate cancer patients? Preliminary results of a pilot study.

    PubMed

    De Bari, B; Vallati, M; Gatta, R; Simeone, C; Girelli, G; Ricardi, U; Meattini, I; Gabriele, P; Bellavita, R; Krengli, M; Cafaro, I; Cagna, E; Bunkheila, F; Borghesi, S; Signor, M; Di Marco, A; Bertoni, F; Stefanacci, M; Pasinetti, N; Buglione, M; Magrini, S M

    2015-07-01

    We tested and compared performances of Roach formula, Partin tables and of three Machine Learning (ML) based algorithms based on decision trees in identifying N+ prostate cancer (PC). 1,555 cN0 and 50 cN+ PC were analyzed. Results were also verified on an independent population of 204 operated cN0 patients, with a known pN status (187 pN0, 17 pN1 patients). ML performed better, also when tested on the surgical population, with accuracy, specificity, and sensitivity ranging between 48-86%, 35-91%, and 17-79%, respectively. ML potentially allows better prediction of the nodal status of PC, potentially allowing a better tailoring of pelvic irradiation. PMID:25950849

  17. Preliminary results of a phase I/II clinical trial using in situ photoimmunotherapy combined with imiquimod for metastatic melanoma patients

    NASA Astrophysics Data System (ADS)

    Li, Xiaosong; Naylor, Mark F.; Nordquist, Robert E.; Teague, T. Kent; Howard, C. Anthony; Murray, Cynthia; Chen, Wei R.

    2010-02-01

    In Situ Photoimmunotherapy (ISPI), a newly developed modality for cancer therapy, has been shown to be able to modulate the body's own immune response. This clinical trial was designed to evaluate the safety and therapeutic effect of ISPI, using imiquimod as its immunoadjuvant for metastatic melanoma patients. ISPI consisted of three main components applied directly to the cutaneous metastases: 1) local application of topical imiquimod; 2) injection of indocyanine green; and 3) an 805 nm laser for local irradiation. All patients completed at least one cycle of treatment. All the patients completed at least one cycle of treatments; one patient received 6 cycles. The most common adverse effects were rash, pruritus, pain, fatigue and anorexia. Fever, chills, vomiting and cellulitis were relative rare. No grade 4 toxicity was observed. Complete Response (CR) was observed in 6 patients. Median overall survival of the 11 evaluated patients was 12.2 months. Six of the eleven patients were still alive at the time of this report. Treatment of ISPI using imiquimod is safe and well tolerant. Our preliminary clinical results suggest that this new method can be a promising modality for metastatic melanoma.

  18. Self-reported quality of life in multiple sclerosis patients: preliminary results based on the Polish MS Registry

    PubMed Central

    Brola, Waldemar; Sobolewski, Piotr; Fudala, Małgorzata; Flaga, Stanisław; Jantarski, Konrad; Ryglewicz, Danuta; Potemkowski, Andrzej

    2016-01-01

    Background The aim of the study was to analyze selected clinical and sociodemographic factors and their effects on the quality of life (QoL) of multiple sclerosis (MS) patients registered in the Polish MS Registry. Methods This was a cross-sectional observational study performed in Poland. Data on personal and disease-specific factors were collected between January 1, 2011, and December 31, 2015, via the web portal of the Polish MS Registry. All patients were assessed by a physician and asked to complete the Polish language versions of the following self-evaluation questionnaires: EuroQol 5-Dimensions, EuroQoL Visual Analog Scale, and Multiple Sclerosis Impact Scale. Univariate analysis and logistic regression were performed to determine the factors associated with QoL. Results The study included 2,385 patients (female/male ratio 2.3:1) with clinically confirmed MS (mean age 37.8±9.2 years). Average EuroQol 5-Dimensions index was 0.72±0.24, and the mean EuroQoL Visual Analog Scale score was 64.2±22.8. The average Multiple Sclerosis Impact Scale score was 84.6±11.2 (62.2±18.4 for physical condition and 23.8±7.2 for mental condition). Lower QoL scores were significantly associated with higher level of disability (odds ratio [OR], 0.932; 95% confidence interval [CI], 0.876–0.984; P=0.001), age >40 years (OR, 1.042; 95% CI, 0.924–1.158; P=0.012), longer disease duration (OR, 0.482; 95% CI, 0.224–0.998; P=0.042), and lack of disease modifying therapies (OR, 0.024; 95% CI, 0.160–0.835; P=0.024). No significant associations were found between QoL, sex, type of MS course, patient’s education, and marital status. Conclusion The Polish MS Registry is the first national registry for long-term observation that allows for self-evaluation of the QoL. QoL of Polish patients with MS is significantly lower compared with the rest of the population. The parameter is mainly affected by the level of disability, duration of the disease, and limited access to

  19. Prospective computer-assisted voice analysis for patients with early stage glottic cancer: A preliminary report of the functional result of laryngeal irradiation

    SciTech Connect

    Harrison, L.B.; Solomon, B.; Miller, S.; Fass, D.E.; Armstrong, J.; Sessions, R.B. )

    1990-07-01

    In January 1987 we began a prospective study aimed at evaluating objective parameters of vocal function for all patients treated with RT for early glottic cancer. All patients underwent vocal analysis using a voice analyzer interfaced with a computer. This allowed for the determination of percent voicing (%V) (normal = presence of phonation = 90-100%V). Other parameters such as breathiness and strain were also measured. Patients were recorded before RT, weekly during RT, and at set intervals after RT. There have been 25 patients studied. Eighteen (18) are evaluable at 9 months after treatment. All patients were male and ranged from 45-84 years old. Fourteen (14) and T1 lesions and received 66 GY/33 fractions to their larynx and 4 had T2 tumors and received 66-70 Gy/33-35 fractions. To date, all patients are locally controlled. Three distinct patterns of %V changes have been encountered. However, all patients demonstrated normal phonation pattern by 3 months after RT, and this is sustained at 9 months follow-up. In addition, 94% of patients have had significant decrease in breathiness after RT, which objectively documents diminished hoarseness. In 83%, breathiness is normal after RT. Most patients have had increased strain after RT, which documents increased vocal cord tension. However, strain remained within normal limits in 89%. Our preliminary analysis suggests that the majority of patients irradiated for early glottic cancer demonstrate a decrease in breathiness and an increase in strain after RT, and enjoy a resultant voice that has normal phonation maintained at 9 months after RT. Our data also demonstrate three distinct phonation patterns. Further follow-up will allow us to determine the prognostic significance, if any, of these patterns, and to continue to follow objective vocal parameters on larger numbers of patient.

  20. Prospective computer-assisted voice analysis for patients with early stage glottic cancer: a preliminary report of the functional result of laryngeal irradiation.

    PubMed

    Harrison, L B; Solomon, B; Miller, S; Fass, D E; Armstrong, J; Sessions, R B

    1990-07-01

    In January 1987 we began a prospective study aimed at evaluating objective parameters of vocal function for all patients treated with RT for early glottic cancer. All patients underwent vocal analysis using a voice analyzer interfaced with a computer. This allowed for the determination of percent voicing (%V) (normal = presence of phonation = 90-100%V). Other parameters such as breathiness (air turbulence or hoarseness) and strain (vocal cord tension) were also measured. Patients were recorded before RT, weekly during RT, and at set intervals after RT. There have been 25 patients studied. Eighteen (18) are evaluable at 9 months after treatment. All patients were male and ranged from 45-84 years old. Fourteen (14) and T1 lesions and received 66 GY/33 fractions to their larynx and 4 had T2 tumors and received 66-70 Gy/33-35 fractions. To date, all patients are locally controlled. Three distinct patterns of %V changes have been encountered. However, all patients demonstrated normal phonation pattern by 3 months after RT, and this is sustained at 9 months follow-up. In addition, 94% of patients have had significant decrease in breathiness after RT, which objectively documents diminished hoarseness. In 83%, breathiness is normal after RT. Most patients have had increased strain after RT, which documents increased vocal cord tension. However, strain remained within normal limits in 89%. Our preliminary analysis suggests that the majority of patients irradiated for early glottic cancer demonstrate a decrease in breathiness and an increase in strain after RT, and enjoy a resultant voice that has normal phonation maintained at 9 months after RT. Our data also demonstrate three distinct phonation patterns. Further follow-up will allow us to determine the prognostic significance, if any, of these patterns, and to continue to follow objective vocal parameters on larger numbers of patient. PMID:2380077

  1. Assessment of femur geometrical parameters using EOS™ imaging technology in patients with atypical femur fractures; preliminary results.

    PubMed

    Morin, Suzanne N; Wall, Michelle; Belzile, Etienne L; Godbout, Benoit; Moser, Thomas P; Michou, Laëtitia; Ste-Marie, Louis-Georges; de Guise, Jacques A; Rahme, Elham; Brown, Jacques P

    2016-02-01

    Atypical femur fractures (AFF) arise in the subtrochanteric and diaphyseal regions. Because of this unique distribution, we hypothesized that patients with AFF demonstrate specific geometrical variations of their lower limb whereby baseline tensile forces applied to the lateral cortex are higher and might favor the appearance of these rare stress fractures, when exposed to bisphosphonates. Using the low irradiation 2D-3D X-ray scanner EOS™ imaging technology we aimed to characterize and compare femur geometric parameters between women who sustained bisphosphonate-associated AFF and those who had experienced similar duration of exposure to bisphosphonates but did not sustain fractures. Conditional logistic regression models were constructed to estimate the association between selected geometric parameters and the occurrence of AFF. We identified 16 Caucasian women with AFF and recruited 16 ethnicity-, sex-, age-, height- and cumulative bisphosphonate exposure-matched controls from local osteoporosis clinics. Compared to controls, those with AFF had more lateral femur bowing (-3.2° SD [3.4] versus -0.8° SD [1.9] p=0.02). In regression analysis, lateral femur bowing was associated with the risk of AFF (aOR 1.54; 95% CI 1.04-2.28, p=0.03). Women who sustained a subtrochanteric AFF demonstrated a lesser femoral neck shaft angle (varus geometry) than those with a fracture at a diaphyseal site (121.9 [3.6]° versus 127.6 [7.2]°, p=0.07), whereas femur bowing was more prominent in those with a diaphyseal fracture compared to those with a subtrochanteric fracture (-4.3 [3.2]° versus -0.9 [2.7]°, p=0.07). Our analyses support that subjects with AFF exhibit femoral geometry parameters that result in higher tensile mechanical load on the lateral femur. This may play a critical role in the pathogenesis of AFF and requires further evaluation in a larger size population. PMID:26541215

  2. Hypofractionated Helical Tomotherapy for Older Aged Patients With Prostate Cancer: Preliminary Results of a Phase I-II Trial.

    PubMed

    Liu, Hai-Xia; Du, Lei; Yu, Wei; Cai, Bo-Ning; Xu, Shou-Ping; Xie, Chuan-Bin; Ma, Lin

    2016-08-01

    In our center, the feasibility and related acute toxicities of hypofractionated helical tomotherapy have been evaluated in older aged patients with prostate cancer . Between February 2009 and February 2014, 67 patients (older than 65 years) were enrolled in a prospective phase I-II study (registered number, ChiCTR-ONC-13004037). Patients in cohort 1 (n = 33) and cohort 2 (n = 34) received 76 Gy in 34 fractions (2.25 Gy/F) and 71.6 Gy in 28 fractions (2.65 Gy/F), respectively, to the prostate and seminal vesicles, while 25 patients in cohort 2 also received integrated elective lymph node irradiation (50.4 Gy). All patients were treated with helical tomotherapy, and daily image guidance was performed before each treatment. Acute toxicities were assessed with Radiation Therapy Oncology Group (RTOG)/European Organization for Research on Treatment of Cancer (EORTC) criteria. No significant difference was detected between the 2 cohorts in the incidence of acute toxicities. In cohort 1, the incidences of grade 1 and 2 genitourinary and gastrointestinal toxicities were 45.5% and 45.4%, respectively, and without grade 3 and 4 toxicities. In cohort 2, the incidences of acute grade 1 and 2 genitourinary and gastrointestinal toxicities were 47.1% and 55.9%, respectively, and grade 3 genitourinary toxicity (hematuria) was noted only in 1 patient. No significant difference was detected in the incidence of acute toxicities between the patients receiving integrated elective lymph node irradiation and those receiving irradiation to prostate and seminal vesicle in cohort 2. Univariate and multivariate analyses were performed with clinical parameters. Only the baseline weight was found negatively correlated with genitourinary toxicities at a weak level (relative risk = 0.946, 95% confidence interval 0.896-0.998], P = .043). This study shows that 2 hypofractionation regimens (76 Gy/34F and 71.6 Gy/28F) delivered with HT are well tolerated in older aged patients having prostate cancer

  3. USSR ethnic composition: preliminary 1989 census results.

    PubMed

    Kingkade, W

    1990-03-01

    Some preliminary results concerning ethnic distribution and language spoken from the 1989 census of the USSR that have been published in the Soviet media are summarized. Comparative data for 1979 are also provided. PMID:12342632

  4. REMS Wind Sensor Preliminary Results

    NASA Astrophysics Data System (ADS)

    De La Torre Juarez, M.; Gomez-Elvira, J.; Navarro, S.; Marin, M.; Torres, J.; Rafkin, S. C.; Newman, C. E.; Pla-García, J.

    2015-12-01

    The REMS instrument is part of the Mars Science Laboratory payload. It is a sensor suite distributed over several parts of the rover. The wind sensor, which is composed of two booms equipped with a set of hot plate anemometers, is installed on the Rover Sensing Mast (RSM). During landing most of the hot plates of one boom were damaged, most likely by the pebbles lifted by the Sky Crane thruster. The loss of one wind boom necessitated a full review of the data processing strategy. Different algorithms have been tested on the readings of the first Mars year, and these results are now archived in the Planetary Data System (PDS), The presentation will include a description of the data processing methods and of the resulting products, including the typical evolution of wind speed and direction session-by-session, hour-by-hour and other kinds of statistics . A review of the wind readings over the first Mars year will also be presented.

  5. Early perfusion changes in patients with recurrent high-grade brain tumor treated with Bevacizumab: preliminary results by a quantitative evaluation

    PubMed Central

    2012-01-01

    Background To determine whether early monitoring of the effects of bevacizumab in patients with recurrent high-grade gliomas, by a Perfusion Computed Tomography (PCT), may be a predictor of the response to treatment assessed through conventional MRI follow-up. Methods Sixteen patients were enrolled in the present study. For each patient, two PCT examinations, before and after the first dose of bevacizumab, were acquired. Areas of abnormal Cerebral Blood Volume (CBV) were manually defined on the CBV maps, using co-registered T1- weighted images, acquired before treatment, as a guide to the tumor location. Different perfusion metrics were derived from the histogram analysis of the normalized CBV (nCBV) maps; both hyper and hypo-perfused sub-volumes were quantified in the lesion, including tumor necrosis. A two-tailed Wilcoxon test was used to establish the significance of changes in the different perfusion metrics, observed at baseline and during treatment. The relationships between changes in perfusion and morphological MRI modifications at first follow-up were investigated. Results Significant reductions in mean and median nCBV were detected throughout the entire patient population, after only a single dose of bevacizumab. The nCBV histogram modifications indicated the normalization effect of bevacizumab on the tumor abnormal vasculature. An improvement in hypoxia after a single dose of bevacizumab was predictive of a greater reduction in T1-weighted contrast-enhanced volumes at first follow-up. Conclusions These preliminary results show that a quantification of changes in necrotic intra-tumoral regions could be proposed as a potential imaging biomarker of tumor response to anti-VEGF therapies. PMID:22494770

  6. Gender Differences in Remission and Recovery of Schizophrenic and Schizoaffective Patients: Preliminary Results of a Prospective Cohort Study

    PubMed Central

    Carpiniello, Bernardo; Pinna, Federica; Tusconi, Massimo; Zaccheddu, Enrico; Fatteri, Francesca

    2012-01-01

    The aim of the paper was to evaluate rates of clinical remission and recovery according to gender in a cohort of chronic outpatients attending a university community mental health center who had been diagnosed with schizophrenia and schizoaffective disorder according to DSM-IV-TR. A sample of 100 consecutive outpatients (70 males and 30 females) underwent comprehensive psychiatric evaluation using the Structured Clinical Interview for Diagnosis of Axis I and II DSM-IV (SCID-I and SCID-II, Version R) and an assessment of psychopathology, social functioning, clinical severity, subjective wellbeing, and quality of life, respectively by means of PANSS (Positive and Negative Syndrome Scale), PSP (Personal and Social Performance), CGI-SCH (Clinical Global Impression—Schizophrenia scale), SWN-S (Subjective Well-being under Neuroleptics—scale), and WHOQOL (WHO Quality of Life). Rates of clinical remission and recovery according to different criteria were calculated by gender. Higher rates of clinical remission and recovery were generally observed in females than males, a result consistent with literature data. Overall findings from the paper support the hypothesis of a better outcome of the disorders in women, even in the very long term. PMID:22966440

  7. Preliminary results, methodological considerations and recruitment difficulties of a randomised clinical trial comparing two treatment regimens for patients with headache and neck pain

    PubMed Central

    De Hertogh, Willem; Vaes, Peter; Devroey, Dirk; Louis, Paul; Carpay, Hans; Truijen, Steven; Duquet, William; Oostendorp, Rob

    2009-01-01

    Background Headache is a highly prevalent disorder. Irrespective of the headache diagnosis it is often accompanied with neck pain and -stiffness. Due to this common combination of headache and neck pain, physical treatments of the cervical spine are often considered. The additional value of these treatments to standard medical care or usual care (UC) is insufficiently documented. We therefore wanted to compare the treatment effects of UC alone and in combination with manual therapy (MT) in patients with a combination of headache and neck pain. UC consisted of a stepped treatment approach according to the Dutch General Practitioners Guideline for headache, the additional MT consisted of articular mobilisations and low load exercises. Due to insufficient enrolment the study was terminated prematurely. We aim to report not only our preliminary clinical findings but also to discuss the encountered difficulties and to formulate recommendations for future research. Methods A randomised clinical trial was conducted. Thirty-seven patients were included and randomly allocated to one of both treatment groups. The treatment period was 6 weeks, with follow-up measurements at weeks 7, 12 and 26. Primary outcome measures were global perceived effect (GPE) and the impact of the headache using the Headache Impact Test (HIT-6). Reduction in headache frequency, pain intensity, medication intake, absenteeism and the use of additional professional help were secondary outcome measures Results Significant improvements on primary and secondary outcome measures were recorded in both treatment groups. No significant differences between both treatment groups were found. The number of recruited patients remained low despite various strategies. Conclusion It appears that both treatment strategies can have equivalent positive influences on headache complaints. Additional studies with larger study populations are needed to draw firm conclusions. Recommendations to increase patient inflow in

  8. [Preventive effect of an immunomodulator, OM-85 BV, on acute exacerbations of chronic bronchitis in elderly patients. Preliminary results at six months in 291 patients].

    PubMed

    Orcel, B; Delclaux, B; Baud, M; Derenne, J P

    1993-01-01

    Three hundred fifty six patients aged 65 years or more (mean age 81.8 years) who were suffering from chronic bronchitis were included in a double-blind trial against placebo to assess the preventative effect of OM-85 BV against acute exacerbations of chronic bronchitis. OM-85 BV is an immunostimulant composed of lyophilised factions of 8 bacteria which are most frequently encountered during the course of respiratory tract infections. 291 patients completed the study. In the group treated by OM-85 BV, a significant increase in the number of patients with no episode of acute bronchitis was noted (96 versus 71, p = 0.006). There was a 38.8% reduction in the absolute numbers of episodes of acute bronchitis and a 33% reduction in the number of prescriptions for antibiotics, however there was no difference in the number of pneumonias and bronchopneumonias. These results show the protective effect of OM-85 BV against bronchial superinfections in a large population of elderly patients suffering from chronic bronchitis. PMID:8451491

  9. Preliminary results of a randomized controlled trial carried out with a fixed combination of S-adenosyl-L-methionine and betaine versus amitriptyline in patients with mild depression

    PubMed Central

    Di Pierro, Francesco; Settembre, Roberto

    2015-01-01

    Background S-adenosyl-L-methionine (SAMe), a safe, endogenous, pleiotropic methyl donor well known for its antidepressant role, has been assumed to have a possible role in increasing plasma levels of compounds known to be able to raise cardiovascular risk. Although the issue is still being debated, betaine (trimethylglycine), a specific methyl donor involved in the homocysteine circuit, may be able to reduce such a risk and/or, by determining a sparing effect on endogenous SAMe, may be able to improve the clinical efficiency of SAMe itself. Indeed, preliminary results have shown clinical improvement determined by an add-on therapy with betaine administered along with SAMe, versus SAMe alone, to patients affected by mild/moderate depression. Aim To evaluate the safety and antidepressant role played by the association of SAMe plus betaine versus amitriptyline administered in untreated individuals with a recent diagnosis of mild depression. Methods This small, open-label, randomized, observational study enrolled 64 individuals with a diagnosis of mild depression according to the Zung Self-Rating Depression Scale. After randomization, they were treated with either Laroxyl® (amitriptyline, 75 mg/day) or DDM Metile® (enteric-coated SAMe, 500 mg/day, plus betaine, 250 mg/day) for 12 months. Assessment of clinical scores and tolerability was performed at T=0 and after 3, 6, and 12 months. Results After 3 months, both treatments showed a small and not statistically significant improvement. After 6 and 12 months, both treated groups demonstrated a more noticeable improved response, although the group treated with SAMe plus betaine showed better results in terms of score, number of individuals in remission, and side effects. Compliance was overlapping in both treatments. Conclusion The association of SAMe plus betaine seems to be a safe and effective tool to counteract mild depression and also when used as monotherapy in subjects with a recent diagnosis. PMID:25678811

  10. [Ethnic entrepreneurship in Montreal: some preliminary results].

    PubMed

    Juteau, D; Daviau-guay, J; Moallem, M

    1992-01-01

    "This research note presents a first sketch of a study we are undertaking on ethnic entrepreneurship [in Montreal]. It details first of all our theoretical framework and then presents some preliminary results. For this research, we are studying various ethnic groups, those in the majority as well as the minority. For each of them, we will analyze the impact that immigration status, sex, the industrial sector and urban context play on entrepreneurial activity." (SUMMARY IN ENG AND SPA) PMID:12287383

  11. I Might Have Some Bad News: Disclosing Preliminary Pathology Results.

    PubMed

    Roh, Michael H; Shuman, Andrew G

    2016-01-01

    Cytopathology is a subspecialty of pathology in which pathologists frequently interact directly with patients. Often this interaction is in the context of fine needle aspiration (FNA) procedures performed at the bedside by the cytopathologist or by another clinician with the cytopathologist present. Patient requests for preliminary results in such settings raise fundamental questions about professional scope of practice and communication of uncertainty that apply not merely to pathologists but to all clinicians. In certain settings, cytopathologists may share preliminary diagnostic impressions directly with patients. Essential to these conversations is the need to articulate potential uncertainty about both the diagnosis and next steps. In addition, the involvement and notification of the referring physician is obligatory, both for care coordination and to ensure that patients receive a consistent message. PMID:27550561

  12. Preliminary impression techniques for microstomia patients.

    PubMed

    Kumar, K Aswini; Bhat, Vinaya; Nair, K Chandrasekheran; Suresh, Reshma

    2016-01-01

    The Prosthetic rehabilitation of microstomia patients presents difficulties at all the stages. The difficulty starts with the preliminary impression making. This is due to the tongue rigidity and the decreased oral opening. A maximum oral opening which is smaller than the size of the tray can make prosthetic treatment challenging. Due to the restricted mouth opening, insertion and removal of the impression trays is extremely cumbersome and various modifications of the trays have been used in the past. Among these are the flexible trays and the sectional trays used with different modes of reassembling the segments extra orally after the impression is made. This article reviews the literature published from 1971 to 2015 concerning preliminary impression techniques used in making impressions for patients with microstomia based on various tray designs. An electronic search was performed across three databases (PubMed, Science Direct and Google Scolar) for relevant citations. The keywords/combinations used for the search were microstomia, limited/constricted/restricted mouth opening/oral access, trismus, sectional trays, impressions and prosthetic/prosthodontic rehabilitation. The search was limited to papers written in English which resulted in a total of 45 related articles of which 17 articles were included for discussion of this review. PMID:27621540

  13. Stereoplotting Hominid Brain Endocasts : Some Preliminary Results

    NASA Astrophysics Data System (ADS)

    Holloway, Ralph L.

    1980-07-01

    To objectively and quantitatively demonstrate regional differences in brain endocast morphology, traditional anthropometric caliper measurements must be replaced by a system providing not only localness, but homology and reasonable freedom from allometric distortion. Stereoplotting the radial distances from endocast surface (the closest point to the once underlying brain cortex) to a homologous center every ten degrees provides some 300+ data points for each dorsal endocast surface, thus giving the requisite localness. These measurements provide a large matrix of data suitable for a number of multivariate statistical techniques, and the translation of such data and analyses to readily visualized maps, which can then be compared in relation to both taxonomic and functional knowledge about the cerebral surface. This paper descri-bes some preliminary results from using such methods on a sample of 64 undistorted endocasts composed of both pongids and fossil hominids. While sample sizes within taxonomic groups need to be augmented, the preliminary and tentative pilot studies conducted so far suggest that the method has excellent potential, and that two major areas of the brain endocast surface show the greatest shape changes : 1) the posterior association areas (inferior parietal lobule); 2) the anterior prefrontal areas.

  14. SLS-1 flight experiments preliminary significant results

    NASA Astrophysics Data System (ADS)

    1992-01-01

    Spacelab Life Sciences-1 (SLS-1) is the first of a series of dedicated life sciences Spacelab missions designed to investigate the mechanisms involved in the physiological adaptation to weightlessness and the subsequent readaptation to 1 gravity (1 G). Hypotheses generated from the physiological effects observed during earlier missions led to the formulation of several integrated experiments to determine the underlying mechanisms responsible for the observed phenomena. The 18 experiments selected for flight on SLS-1 investigated the cardiovascular, cardiopulmonary, regulatory physiology, musculoskeletal, and neuroscience disciplines in both human and rodent subjects. The SLS-1 preliminary results gave insight to the mechanisms involved in the adaptation to the microgravity environment and readaptation when returning to Earth. The experimental results will be used to promote health and safety for future long duration space flights and, as in the past, will be applied to many biomedical problems encountered here on Earth.

  15. Progress and Preliminary Results on EB Stepper

    NASA Astrophysics Data System (ADS)

    Kawata, Shintaro; Hamashima, Muneki; Miura, Takaharu; Suzuki, Kazuaki; Okamoto, Kazuya; Yamaguchi, Takeshi

    2002-06-01

    The EB stepper is an electron beam projection lithography (EPL) system. The EB stepper system is similar to an optical scanning exposure system with a reticle. Nikon has been developing EB stepper on the basis of the optical stepper design. The field size of the electron optical (EO) subsystem of EB stepper (subfield/(SF)) is 1 mm square on a reticle and 250 μm square on a wafer (demagnification: 4×). For full chip exposure, SF exposures are stitched using electron beam deflection and stage movement. A new type of stage has been developed for EB stepper using air guides and linear motors to achieve a high-throughput target. These subsystems are assembled separately at present. In this paper, preliminary results on EB stepper as an exposure system are reported. Progress on infrastructures for EPL is discussed.

  16. Breakthrough Propulsion Physics Workshop Preliminary Results

    NASA Technical Reports Server (NTRS)

    Millis, Marc G.

    1997-01-01

    In August, 1997, a NASA workshop was held to assess the prospects emerging from physics that might lead to creating the ultimate breakthroughs in space transportation: propulsion that requires no propellant mass, attaining the maximum transit speeds physically possible, and breakthrough methods of energy production to power such devices. Because these propulsion goals are presumably far from fruition, a special emphasis was to identify affordable, near-term, and credible research that could make measurable progress toward these propulsion goals. Experiments and theories were discussed regarding the coupling of gravity and electromagnetism, vacuum fluctuation energy, warp drives and wormholes, and superluminal quantum tunneling. Preliminary results of this workshop are presented, along with the status of the Breakthrough Propulsion Physics program that conducted this workshop.

  17. Multimode electromagnetic target discriminator: preliminary data results

    NASA Astrophysics Data System (ADS)

    Black, Christopher J.; McMichael, Ian T.; Nelson, Carl V.

    2004-09-01

    This paper describes the Multi-mode Electromagnetic Target Discriminator (METD) sensor and presents preliminary results from recent field experiments. The METD sensor was developed for the US Army RDECOM NVESD by The Johns Hopkins University Applied Physics Laboratory. The METD, based on the technology of the previously developed Electromagnetic Target Discriminator (ETD), is a spatial scanning electromagnetic induction (EMI) sensor that uses both the time-domain (TD) and the frequency-domain (FD) for target detection and classification. Data is collected with a custom data acquisition system and wirelessly transmitted to a base computer. We show that the METD has a high signal-to-noise ratio (SNR), the ability to detect voids created by plastic anti-tank (AT) mines, and is practical for near real-time data processing.

  18. Diagnostics of Sacroiliitis According to ASAS Criteria: A Comparative Evaluation of Conventional Radiographs and MRI in Patients with a Clinical Suspicion of Spondyloarthropathy. Preliminary Results

    PubMed Central

    Sudoł-Szopińska, Iwona; Kwiatkowska, Brygida; Włodkowska-Korytkowska, Monika; Matuszewska, Genowefa; Grochowska, Elżbieta

    2015-01-01

    Summary Background The objective of this study was a comparative evaluation of radiography and MRI in the diagnostics of sacroiliitis in patients with a clinical diagnosis of spondyloartropathy, according to the current ASAS criteria. Material/Methods Sacroiliac joints radiograms and MRI were conducted in 101 consecutive patients, aged 19–71 yrs (mean age: 40.6 yrs). The patients were referred by a senior rheumatologist, with symptoms of the chronic back pain. The sacroiliac joints were assessed on AP radiograms of the pelvis according to the modified New York criteria for ankylosing spondylitis. MRI was performed to look for active and chronic inflammatory lesions. Results Of 14 patients with radiographic sacroiliitis according to modified New York criteria, only 50% had sacroiliitis on MRI. The sensitivity and specificity of conventional radiography were 22% and 94% and of MRI were 71% and 90%. Cohen’s kappa coefficient was κ=0.0187, agreement of radiograms and MRI was 58%. Among 86 patients displaying no sacroiliitis on radiograms, MRI showed sacroiliitis in 34 patients (39.5%). Positive predictive value was 0.429, negative predictive value was 0.605. Conclusions MRI allowed to diagnose sacroiliitis in 39,5 % of patients in preradiographic stage. MRI ruled out the presence of active inflammatory lesions in 60.4% of patients with sacroiliitis on radiograms according to modified New York criteria. PMID:26082819

  19. Preliminary Results From a Prospective Study Using Limited Margin Radiotherapy in Pediatric and Young Adult Patients With High-Grade Nonrhabdomyosarcoma Soft-Tissue Sarcoma

    SciTech Connect

    Krasin, Matthew J.; Davidoff, Andrew M.; Xiong Xiaoping; Wu Shengjie; Hua, C.-H.; Navid, Fariba; Rodriguez-Galindo, Carlos; Rao, Bhaskar N.; Hoth, Kelly A.; Neel, Michael D.; Merchant, Thomas E.; Kun, Larry E.; Spunt, Sheri L.

    2010-03-01

    Purpose: To demonstrate the safety and efficacy of limited margin radiotherapy in the local control of pediatric and young adult patients with high-grade nonrhabdomyosarcoma soft tissue sarcoma (NRSTS). Methods and Materials: Pediatric patients with high-grade NRSTS requiring radiation were treated on an institutional review board approved prospective institutional study of conformal/intensity-modulated/interstitial brachytherapy using a 2-cm anatomically constrained margin. Results: A total of 32 patients (median age, 15.3 years; range, 2-22 years) received adjuvant (27 patients) or definitive (5 patients) irradiation. With a median follow-up of 32 months, the 3-year cumulative incidence of local failure was 3.7% for patients undergoing irradiation after surgical resection. Four patients experienced local failure; the mean dose to the volume of recurrence was >=97% of the prescribed dose. Conclusions: Delivery of limited margin radiotherapy using external beam or brachytherapy provides a high rate of local tumor control without marginal failure. Further follow-up is required to determine whether normal tissue effects are minimized using this approach.

  20. The Viking biological investigation - Preliminary results

    NASA Technical Reports Server (NTRS)

    Klein, H. P.; Oyama, V. I.; Berdahl, B. J.; Horowitz, N. H.; Hobby, G. L.; Levin, G. V.; Straat, P. A.; Lederberg, J.; Rich, A.; Hubbard, J. S.

    1976-01-01

    A preliminary progress report is presented for the Viking biological investigation through its first month. The carbon assimilation, gas exchange, and labeled release experiments are described in detail, and the chronology of the experiments is outlined. For the first experiment, it is found that a small amount of gas was converted into organic material in one sample and that heat treatment of a duplicate sample prevented such conversion. In the second experiment, a substantial amount of O2 was detected along with significant increases in CO2 and small changes in N2. In the third experiment, a significant amount of radioactive gas was evolved from one sample, but not from a duplicate heat-treated sample. Possible biological and nonbiological interpretations are considered for these results. It is concluded that while the experiments provide clear evidence for the occurrence of chemical reactions and while the results do not violate any prima facie criteria for biological processes, a definitive answer cannot yet be given to the question of whether life exists on Mars.

  1. Viking first encounter of phobos: preliminary results.

    PubMed

    Tolson, R H; Duxbury, T C; Born, G H; Christensen, E J; Diehl, R E; Farless, D; Hildebrand, C E; Mitchell, R T; Molko, P M; Morabito, L A; Palluconi, F D; Reichert, R J; Taraji, H; Veverka, J; Neugebauer, G; Findlay, J T

    1978-01-01

    During the last 2 weeks of February 1977, an intensive scientific investigation of the martian satellite Phobos was conducted by the Viking Orbiter-1 (VO-1) spacecraft. More than 125 television pictures were obtained during this period and infrared observations were made. About 80 percent of the illuminated hemisphere was imaged at a resolution of about 30 meters. Higher resolution images of limited areas were also obtained. Flyby distances within 80 kilometers of the surface were achieved. An estimate of the mass of Phobos (GM) was obtained by observing the effect of Phobos's gravity on the orbit of VO-1 as sensed by Earth-based radiometric tracking. Preliminary results indicate a value of GM of 0.00066 +/- 0.00012 cubic kilometer per second squared (standard deviation of 3) and a mean density of about 1.9 +/- 0.6 gram per cubic centimeter (standard deviation of 3). This low density, together with the low albedo and the recently determined spectral reflectance, suggest that Phobos is compositionally similar to type I carbonaceous chondrites. Thus, either this object formed in the outer part of the asteroid belt or Lewis's theory that such material cannot condense at 1.5 astronomical units is incorrect. The data on Phobos obtained during this first encounter period are comparable in quantity to all of the data on Mars returned by Mariner flights 4, 6, and 7. PMID:17841954

  2. Preliminary Results of the MARE Experiment

    NASA Astrophysics Data System (ADS)

    Ferri, E.; Bagliani, D.; Biassotti, M.; Ceruti, G.; Corsini, D.; Faverzani, M.; Gatti, F.; Giachero, A.; Gotti, C.; Kilbourne, C.; Kling, A.; Kraft-Bermuth, S.; Maino, M.; Manfrinetti, P.; Nucciotti, A.; Pessina, G.; Pizzigoni, G.; Ribeiro Gomes, M.; Schaeffer, D.; Sisti, M.

    2014-09-01

    The microcalorimeter array for a rhenium experiment (MARE) project aims at the direct and calorimetric measurement of the electron neutrino mass with sub-eV sensitivity. The design is based on large arrays of thermal detectors to study the beta decay of Re and the electron capture of Ho. One of the activities of the project, MARE 1 in Milan, has started in Milan using one array of 6 6 silicon implanted thermistors equipped with AgReO absorbers. The purposes of MARE 1 in Milan are to achieve a sensitivity on the neutrino mass of a few eV and to investigate the systematics of Re neutrino mass measurements, focusing on those caused by the beta environmental fine structure and the beta spectrum theoretical shape. In parallel, the MARE collaboration is performing an R&D work for producing absorbers embedded with radioactive metal Ho. We report here the status of MARE using Re as beta source and the preliminary results obtained with Ho.

  3. Preliminary test results for the SVX4

    SciTech Connect

    Christofek, L.; Hanagaki, K.; Rapidis, P.; Utes, M.; /Fermilab

    2005-06-01

    We present and summarize the preliminary test results for SVX4 chip testing. There are presently two versions of the SVX4. Version 2 has on-chip bypassing and Version 1 does not. The on-chip bypassing is a layer of transistors under the front-end analog pipeline that acts as a bypassing capacitor for the voltage supply. Its size is about a microfarad. We aggressively choose to test Version 2 because of this feature. The feature is advantageous for hybrid design because it eliminates the need for an additional passive component on the hybrid itself by placing it on the actual SVX4 die. Also, the SVX4 was designed to operate in two modes: D. and CDF. One can set which mode the chip will operate by placing a jumper in the proper position on the SVX4 chip carrier. In either mode, the chip can either use the operating parameters from the shift register or the shadow register. Similarly, this is selected by placing a jumper on the SVX4 chip carrier. This chip has this feature because it was unknown whether the new design of the shadow register would be operable. The shadow register is also call the SEU register or Single Event Upset register. An introduction into the functionality of the chip and an explanation on the difference between D. and CDF mode can be found in the SVX4 User's Manual [1].

  4. Preliminary results of radiation measurements on EURECA

    NASA Technical Reports Server (NTRS)

    Benton, E. V.; Frank, A. L.

    1995-01-01

    The eleven-month duration of the EURECA mission allows long-term radiation effects to be studied similarly to those of the Long Duration Exposure Facility (LDEF). Basic data can be generated for projections to crew doses and electronic and computer reliability on spacecraft missions. A radiation experiment has been designed for EURECA which uses passive integrating detectors to measure average radiation levels. The components include a Trackoscope, which employs fourteen plastic nuclear track detector (PNTD) stacks to measure the angular dependence of high LET (greater than or equal to 6 keV/micro m) radiation. Also included are TLD's for total absorbed doses, thermal/resonance neutron detectors (TRND's) for low energy neutron fluences and a thick PNTD stack for depth dependence measurements. LET spectra are derived from the PNTD measurements. Preliminary TLD results from seven levels within the detector array show that integrated does inside the flight canister varied from 18.8 +/- 0.6 cGy to 38.9 +/- 1.2 cGy. The TLD's oriented toward the least shielded direction averaged 53% higher in dose than those oriented away from the least shielded direction (minimum shielding toward the least shielded direction varied from 1.13 to 7.9 g/cm(exp 2), Al equivalent). The maximum dose rate on EURECA (1.16 mGy/day) was 37% of the maximum measured on LDEF and dose rates at all depths were less than measured on LDEF. The shielding external to the flight canister covered a greater solid angle about the canister than the LDEF experiments.

  5. Preliminary results of radiation measurements on EURECA

    NASA Technical Reports Server (NTRS)

    Benton, E. V.; Frank, A. L.

    1995-01-01

    The eleven-month duration of the EURECA mission allows long term radiation effects to be studied similarly to those of the Long Duration Exposure Facility (LDEF). Basic data can be generated for projections of crew doses and electronic and computer reliability on spacecraft missions. A radiation experiment has been designed for EURECA which uses passive integrating detectors to measure average radiation levels. The components include a Trackoscope, which employs fourteen plastic nuclear track detector (PNTD) stacks to measure the angular dependence of LET (greater than or equal to 6 keV/microns) radiation. Also included are TLD's for total absorbed doses, thermal/resonance neutron detectors (TRND's) for low energy neutron fluences and a thick PNTD stack for depth dependence measurements. LET spectra are derived from the PNTD measurements. Preliminary TLD results from seven levels within the detector array show that integrated doses inside the flight canister varied from 18.8 plus or minus 0.6 cGy to 38.9 plus or minus 1.2 cGy. The TLD's oriented toward the least shielded direction averaged 53 percent higher in dose than those oriented away from the least shielded direction (minimum shielding toward the least shielded direction varied from 1.13 to 7.9 g/cm(exp 2), Al equivalent). The maximum dose rate on EURECA (1.16 mGy/day) was 37 percent of the maximum measured on LDEF and dose rates at all depths were less than measured on LDEF. The shielding external to the flight canister covered a greater solid angle about the canister than in the LDEF experiments.

  6. Global Geologic Mapping of Io: Preliminary Results

    NASA Technical Reports Server (NTRS)

    Williams, David A.; Keszthelyi, L. P.; Crown, D. A.; Geissler, P. E.; Schenk, P. M.; Yff, Jessica; Jaeger, W. L.; Rathbun, J. A.

    2008-01-01

    A new global geologic map of Jupiter's volcanic moon, Io is being prepared, with the focus being on completion of a draft map by July 2008. Here initial results of the mapping are reported: a preliminary distribution of material units in terms of areas and a visual representation. Additionally, the mapping hopes to address some of the problems in Io geology. Thus far it has been discovered that Io's surface is dominated by plains material, thought to consist of Io's silicate crust covered by pyroclastic deposits and lava flows of silicate and sulfur-bearing composition. Many plains areas contain flow fields that cannot be mapped separately due to a lack of resolution or modification by alteration processes. Discrete lava flows and flow fields are the next most abundant unit, with bright (sulfur?) flows in greater abundance than dark (silicate?) flows. The source of most of Io's heat flow, the paterae, are the least abundant unit in terms of areal extent.Upon completion of the draft map for peer review, it will be used to investigate several specific questions about the geological evolution of Io that previously could not be well addressed, including: comparison of the areas versus the heights of Ionian mountains to assess their stability and evolution; correlation and comparison of Galileo Near-Infrared Mapping Spectrometer and Photopolarimeter-Radiometer hot spot locations with the mapped location of dark versus bright lava flows and patera floors to assess any variations in the types of sources for Io's active volcanism; and the creation of a global inventory of the areal coverage of dark and bright laval flows to assess the relative importance of sulfur versus silicate volcanism in resurfacing Io, and to assess whether there are regional concentrations of either style of volcanism that may have implications on interior processes.

  7. The effect of long Roux-en-Y gastrojejunostomy in gastric cancer patients with type 2 diabetes and body mass index < 35 kg/m2: preliminary results

    PubMed Central

    Kim, Ji Won; Kim, Kwang Yong; Lee, Seung Chul; Yang, Dae Hyun

    2015-01-01

    Purpose We applied a long Roux-en-Y (RY) gastrojejunostomy (bypassed jejunum over 100 cm) as a reconstruction method for diabetes control to gastric cancer patients with type 2 diabetes and body mass index (BMI) < 35 kg/m2. The effect of this procedure on diabetes control was assessed. Methods We prospectively performed modified RY gastrojejunostmy after curative radical distal gastrectomy. Thirty patients had completed a 1-year follow-up. Patients were followed concerning their diabetic status. The factors included in the investigation were length of bypassed jejunum, BMI and its reduction ratio, glycated hemoglobin (HbA1c), fasting blood glucose, and duration of diabetes. Diabetic status after surgery was assessed in three categories: remission, improvement, and stationary. In evaluation of surgical effects on diabetes control, remission and improvement groups were regarded as effective groups, while stationary was regarded as an ineffective group. Results At postoperative one year, statistical significance was observed in the mean BMI and HbA1c. Diabetes control was achieved in 50% of the patients (remission, 30%; improvement, 20%). BMI reduction ratio, preoperative HbA1c, and duration of diabetes were correlated to the status of type 2 diabetes mellitus. The preoperative HbA1c was the most influential predictor in diabetic control. Conclusion The effect of long RY gastrojejunostomy after gastrectomy for diabetes control could be contentious but an applicable reconstruction method for diabetes control in gastric cancer patients with type 2 diabetes and BMI < 35 kg/m2. Diabetes remission is expected to be higher in patients with greater BMI reduction, short duration of diabetes, and lower preoperative HbA1c. PMID:25844356

  8. Tellurium in active volcanic environments: Preliminary results

    NASA Astrophysics Data System (ADS)

    Milazzo, Silvia; Calabrese, Sergio; D'Alessandro, Walter; Brusca, Lorenzo; Bellomo, Sergio; Parello, Francesco

    2014-05-01

    Tellurium is a toxic metalloid and, according to the Goldschmidt classification, a chalcophile element. In the last years its commercial importance has considerably increased because of its wide use in solar cells, thermoelectric and electronic devices of the last generation. Despite such large use, scientific knowledge about volcanogenic tellurium is very poor. Few previous authors report result of tellurium concentrations in volcanic plume, among with other trace metals. They recognize this element as volatile, concluding that volcanic gases and sulfur deposits are usually enriched with tellurium. Here, we present some results on tellurium concentrations in volcanic emissions (plume, fumaroles, ash leachates) and in environmental matrices (soils and plants) affected by volcanic emissions and/or deposition. Samples were collected at Etna and Vulcano (Italy), Turrialba (Costa Rica), Miyakejima, Aso, Asama (Japan), Mutnovsky (Kamchatka) at the crater rims by using common filtration techniques for aerosols (polytetrafluoroethylene filters). Filters were both eluted with Millipore water and acid microwave digested, and analyzed by inductively coupled plasma mass spectrometry (ICP-MS). Volcanic ashes emitted during explosive events on Etna and Copahue (Argentina) were analyzed for tellurium bulk composition and after leaching experiments to evaluate the soluble fraction of tellurium. Soils and leaves of vegetation were also sampled close to active volcanic vents (Etna, Vulcano, Nisyros, Nyiragongo, Turrialba, Gorely and Masaya) and investigated for tellurium contents. Preliminary results showed very high enrichments of tellurium in volcanic emissions comparing with other volatile elements like mercury, arsenic, thallium and bismuth. This suggests a primary transport in the volatile phase, probably in gaseous form (as also suggested by recent studies) and/or as soluble salts (halides and/or sulfates) adsorbed on the surface of particulate particles and ashes. First

  9. Results from a preliminary review of scientific evidence for appropriateness of preparations, dosage forms and other product design elements for older adult patients.

    PubMed

    Messina, Rossella; Becker, Robert; van Riet-Nales, Diana A; Stegemann, Sven

    2015-01-30

    The aging population and the growing multimorbidity of the major patient population as well as the advanced (pharmaco)therapeutic treatment options are increasing the complexity of independent drug therapy management and administration. The increased complexity may have an impact on drug adherence (including any need for patients initiated coping strategies), and consequently on the safety and efficacy of the medicine. To overcome adherence issues caused by the design of the medicine, it is crucial that developers consider the age appropriateness of the medicine (route of administration, dosage form, excipients in the composition, frequency of dosing) in meeting patients' needs to manage their therapy without the support of a care giver. In order to understand the scientific evidence on such age appropriately designed medicines for use by older adults, a literature search was performed in the Medline database (all languages included). The search produced 34 publications that met the inclusion and exclusion criteria for the patient population of 65 years an older. An in-depth analysis of the included publications with respect to the methodological quality (study design, data collection, endpoints chosen) and results showed that none of these publications had adequately investigated the age appropriateness of the medicine for use by older adults. The authors consider that the knowledge gap in this area requires attention of all stakeholders in the healthcare community. PMID:25445516

  10. Digital myelography of spinal dysraphism in infancy: preliminary results

    SciTech Connect

    Barnes, P.D.; Reynolds, A.F.; Galloway, D.C.; Pollay, M.; Leonard, J.C.; Prince, J.R.

    1984-06-01

    For the past 2 years, the authors have used metrizamide myelography with simple, thick-section polytomography (myelotomography) to evaluate patients with spinal dysraphism. This technique has provided separation of simultaneously imaged bone and neural landmarks in standard surgical planes, while directing CT for specific transaxial plane imaging. It also allows reduction in metrizamide dosage and total radiation exposure as compared with previously used myelographic procedures employing multiple plain filming plus complex thin-section tomography. For further reductions in risk and cost, digital fluorographic techniques are currently being explored. They describe preliminary results with digital myelography in the evaluation of spinal dysraphism in infancy.

  11. Evaluation of an oral appliance in patients with mild to moderate obstructive sleep apnea syndrome intolerant to continuous positive airway pressure use: Preliminary results.

    PubMed

    Cantore, S; Ballini, A; Farronato, D; Malcangi, G; Dipalma, G; Assandri, F; Garagiola, U; Inchingolo, F; De Vito, D; Cirulli, N

    2016-06-01

    Obstructive sleep apnea syndrome (OSAS) is a phenomenon of repeated, episodic reduction, or cessation of airflow (hypopnea/apnea) as a result of upper airways obstruction. First-line treatment in younger children is adenotonsillectomy, although other available treatment options in middle-aged adults include continuous positive airways pressure (CPAP) and airway adjuncts. Oral appliances (OA) are a viable treatment alternative in patients with OSAS.The objective of this study was to assess, in a 1-year follow-up study, an OA in OSAS patients. The participants were subjected to polysomnographic examination with a validated device (MicroMESAM). Eight participants were fitted with a Thornton Adjustable Positioner (TAP). The participants were asked to wear the test appliance for 7 nights, and in case of compliance, for 6 months. The selected patients record their usage of the appliance and any adverse effects in a treatment journal. The research focused on the following outcomes: sleep apnea (i.e. reduction in the apnea/hypopnea index) and the effect of oral appliances on daytime function.In conclusion, the results suggest that OA have a definite role in the treatment of snoring and sleep apnea. PMID:26684627

  12. X-48B Preliminary Flight Test Results

    NASA Technical Reports Server (NTRS)

    Taylor, Brian R.

    2009-01-01

    This slide presentation reviews the preliminary Flight tests of the X-48B development program. The X-48B is a blended wing body aircraft that is being used to test various features of the BWB concept. The research concerns the following: (1) Turbofan Development, (2) Intelligent Flight Control and Optimization, (3) Airdata Calibration (4) Parameter Identification (i.e., Determination of the parameters of a mathematical model of a system based on observation of the system inputs and response.)

  13. Fibre tracking: probabilistic approach and preliminary results

    NASA Astrophysics Data System (ADS)

    Torresin, A.; Moscato, A.; Minella, M.; Cardinale, F.; Minati, L.; Aquino, D.

    2009-01-01

    The aim of this work is to have a preliminary experience with probabilistic tractography. We performed fibres reconstruction for three tracts of interest with data obtained from two MR imaging units equipped with different gradients system. An acquisition protocol optimization has been necessary in order to obtain a good trade-off between image quality and data collection time. Possible solutions to acquisition and processing problems are discussed. Future developments and possible applications in neurosurgery are also suggested.

  14. Plantar Pressure Changes and Correlating Risk Factors in Chinese Patients with Type 2 Diabetes: Preliminary 2-year Results of a Prospective Study

    PubMed Central

    Qiu, Xuan; Tian, De-Hu; Han, Chang-Ling; Chen, Wei; Wang, Zhan-Jian; Mu, Zhen-Yun; Liu, Kuan-Zhi

    2015-01-01

    Background: Plantar pressure serves as a key factor for predicting ulceration in the feet of diabetes patients. We designed this study to analyze plantar pressure changes and correlating risk factors in Chinese patients with type 2 diabetes. Methods: We recruited 65 patients with type 2 diabetes. They were invited to participate in the second wave 2 years later. The patients completed identical examinations at the baseline point and 2 years later. We obtained maximum force, maximum pressure, impulse, pressure-time integral, and loading rate values from 10 foot regions. We collected data on six history-based variables, six anthropometric variables, and four metabolic variables of the patients. Results: Over the course of the study, significant plantar pressure increases in some forefoot portions were identified (P < 0.05), especially in the second to forth metatarsal heads. Decreases in heel impulse and pressure-time integral levels were also found (P < 0.05). Plantar pressure parameters increased with body mass index (BMI) levels. Hemoglobin A1c (HbA1c) changes were positively correlated with maximum force (β = 0.364, P = 0.001) and maximum pressure (β = 0.366, P = 0.002) changes in the first metatarsal head. Cholesterol changes were positively correlated with impulse changes in the lateral portion of the heel (β = 0.179, P = 0.072) and pressure-time integral changes in the second metatarsal head (β = 0.236, P = 0.020). Ankle-brachial index (ABI) changes were positively correlated with maximum force changes in the first metatarsal head (β = 0.137, P = 0.048). Neuropathy symptom score (NSS) and common peroneal nerve sensory nerve conduction velocity (SCV) changes were positively correlated with some plantar pressure changes. In addition, plantar pressure changes had a correlation with the appearance of infections, blisters (β = 0.244, P = 0.014), and calluses over the course of the study. Conclusions: We should pay attention to the BMI, HbA1c, cholesterol, ABI

  15. A Phase II Study of Bevacizumab in Combination With Definitive Radiotherapy and Cisplatin Chemotherapy in Untreated Patients With Locally Advanced Cervical Carcinoma: Preliminary Results of RTOG 0417

    SciTech Connect

    Schefter, Tracey E.; Winter, Kathryn; Kwon, Janice S.; Stuhr, Kelly; Balaraj, Khalid; Yaremko, Brian P.; Small, William; Gaffney, David K.

    2012-07-15

    Purpose: Concurrent cisplatin-based chemoradiotherapy (CRT) is the standard treatment for locally advanced cervical cancer. RTOG 0417 was a Phase II study exploring the safety and efficacy of the addition of bevacizumab to standard CRT. Methods and Materials: Eligible patients with bulky tumors (Stage IB-IIIB) were treated with once-weekly cisplatin (40 mg/m{sup 2}) chemotherapy and standard pelvic radiotherapy and brachytherapy. Bevacizumab was administered at 10 mg/kg intravenously every 2 weeks for three cycles. Treatment-related serious adverse event (SAE) and other adverse event (AE) rates within the first 90 days from treatment start were determined. Treatment-related SAEs were defined as any Grade {>=}4 vaginal bleeding or thrombotic event or Grade {>=}3 arterial event, gastrointestinal (GI) bleeding, or bowel/bladder perforation, or any Grade 5 treatment-related death. Treatment-related AEs included all SAEs and Grade 3 or 4 GI toxicity persisting for >2 weeks despite medical intervention, Grade 4 neutropenia or leukopenia persisting for >7 days, febrile neutropenia, Grade 3 or 4 other hematologic toxicity, and Grade 3 or 4 GI, renal, cardiac, pulmonary, hepatic, or neurologic AEs. All AEs were scored using the National Cancer Institute Common Terminology Criteria (CTCAE) v 3.0 (MedDRA version 6.0). Results: A total of 60 patients from 28 institutions were enrolled between 2006 and 2009, and of these, 49 patients were evaluable. The median follow-up was 12.4 months (range, 4.6-31.4 months).The median age was 45 years (range, 22-80 years). Most patients had FIGO Stage IIB (63%) and were of Zubrod performance status of 0 (67%). 80% of cases were squamous. There were no treatment-related SAEs. There were 15 (31%) protocol-specified treatment-related AEs within 90 days of treatment start; the most common were hematologic (12/15; 80%). 18 (37%) occurred during treatment or follow-up at any time. 37 of the 49 patients (76%) had cisplatin and bevacizumab

  16. AVASCULAR NECROSIS OF THE FEMORAL HEAD IN HIV-INFECTED PATIENTS: PRELIMINARY RESULTS FROM SURGICAL TREATMENT FOR CERAMIC-CERAMIC JOINT REPLACEMENT

    PubMed Central

    Cabrita, Henrique Amorim; Santos, Alexandre Leme de Godoy; Gobbi, Riccardo Gomes; Lima, Ana Lúcia Munhoz; Oliveira, Priscila Rosalba; Ejnisman, Leandro; Gurgel, Henrique Melo Campos; Uip, David; Camanho, Gilberto Luis

    2015-01-01

    Objectives: To evaluate the initial functional results and early complication rate of ceramic-ceramic total hip replacements among patients living with HIV who presented osteonecrosis of the femoral head. Method: Twelve HIV–positive patients with a diagnosis of osteonecrosis of the incongruent femoral head were evaluated using clinical and laboratory criteria and the WOMAC functional scale before and after treatment with joint replacement. Results: We observed that 83.3% of the subjects were taking protease inhibitors, 75% had dyslipidemia and 66.6% had lipodystrophy syndrome. The improvement over the evolution of the WOMAC score was statistically significant at six and twelve months after the operation, in comparison with the preoperative score. We did not observe complications secondary to this procedure. Conclusion: Total hip arthroplasty with a ceramic-ceramic implant for treating avascular necrosis of the hip is an appropriate surgical option for this portion of the population. It provides a significant initial functional improvement and a low early complication rate. PMID:27047876

  17. Effects of brain-computer interface-based functional electrical stimulation on balance and gait function in patients with stroke: preliminary results

    PubMed Central

    Chung, EunJung; Park, Sang-In; Jang, Yun-Yung; Lee, Byoung-Hee

    2015-01-01

    [Purpose] The purpose of this study was to determine the effects of brain-computer interface (BCI)-based functional electrical stimulation (FES) on balance and gait function in patients with stroke. [Subjects] Subjects were randomly allocated to a BCI-FES group (n=5) and a FES group (n=5). [Methods] The BCI-FES group received ankle dorsiflexion training with FES according to a BCI-based program for 30 minutes per day for 5 days. The FES group received ankle dorsiflexion training with FES for the same duration. [Results] Following the intervention, the BCI-FES group showed significant differences in Timed Up and Go test value, cadence, and step length on the affected side. The FES group showed no significant differences after the intervention. However, there were no significant differences between the 2 groups after the intervention. [Conclusion] The results of this study suggest that BCI-based FES training is a more effective exercise for balance and gait function than FES training alone in patients with stroke. PMID:25729205

  18. [A clinical and cytogenetic investigation carried out in a special institution for mentally retarded patients: preliminary results concerning 82 cases of oligophrenia (author's transl)].

    PubMed

    Mounoud, R L; Klein, D; Bettschart, W; Cabrol, C

    1976-12-01

    A clinical and cytogenetic investigation carried out in a special institution for mentally retarded patients revealed 82 cases of oligophrenia, amongst whom were found 56 normal karyotypes (68.3%). Out of 25 karyotypes with chromosome anomalies or variants there were 18 cases of trisomy 21 and 7 others: one case of mosaicism with balanced translocation, 46,XX/46,XX,6p+,17q-; one case of partial trisomy, 46,XX,11q+; one case of pericentric inversion, 46,XY,inv(1) (p13,q21); one case with 8% chromosome breaks; three cases of marker chromosomes, of which one was of karyotype 46,XX,1qh+, and two (oligophrenic sisters) 46,XX,21p+. Moreover, there was an interesting case of testicular feminisation in a 9-year-old girl with karyotype 46,XY. The authors' results corroborate those obtained in several important previous studies based on much larger numbers of patients. Amongst the 56 cases where the karyotype was shown to be normal, there were 15 for whom a probably exogenic cause of the oligophrenia could be established, occurring mainly during the perinatal period. The authors were also able to confirm that the genetic factor plays an important role in the incidence of mental retardation, since in 22 examined patients, i.e. 26.8% of all cases, the condition was of familial type. Some interesting observations of idiopathic oligophrenia are reported, as well as several cases with well-known syndromes (Crouzon's and Cornelia de Lange's syndromes, hypothyroidism). Two cases of incest between father and daughter, which had produced children with serious oligophrenia associated, in one case, with deaf-mutism, microphthalmia, microcephaly and sclerocornea, are also discussed. The data show that mental retardation can frequently have a genetic cause, either of mendelian, chromosomal or multifactorial origin. PMID:1022853

  19. Imaging Tumor Perfusion and Oxidative Metabolism in Patients With Head-and-Neck Cancer Using 1- [{sup 11}C]-Acetate PET During Radiotherapy: Preliminary Results

    SciTech Connect

    Sun Aijun; Johansson, Silvia; Turesson, Ingela; Dasu, Alexandru; Soerensen, Jens

    2012-02-01

    Background: A growing body of in vitro evidence links alterations of the intermediary metabolism in cancer to treatment outcome. This study aimed to characterize tumor oxidative metabolism and perfusion in vivo using dynamic positron emission tomography (PET) with 1- [{sup 11}C]-acetate (ACE) during radiotherapy. Methods and Materials: Nine patients with head-and-neck cancer were studied. Oxidative metabolic rate (k{sub mono}) and perfusion (rF) of the primary tumors were assessed by dynamic ACE-PET at baseline and after 15, 30, and 55 Gy was delivered. Tumor glucose uptake (Tglu) was evaluated with [{sup 18}F]-fluorodeoxyglucose PET at baseline. Patients were grouped into complete (CR, n = 6) and partial responders (PR, n = 3) to radiotherapy. Results: The 3 PR patients died within a median follow-up period of 33 months. Baseline k{sub mono} was almost twice as high in CR as in PR (p = 0.02) and Tglu was lower in CR than in PR (p = 0.04). k{sub mono} increased during radiotherapy in PR (p = 0.004) but remained unchanged in CR. There were no differences in rF between CR and PR at any dosage. k{sub mono} and rF were coupled in CR (p = 0.001), but not in PR. Conclusions: This study shows that radiosensitive tumors might rely predominantly on oxidative metabolism for their bioenergetic needs. The impairment of oxidative metabolism in radioresistant tumors is potentially reversible, suggesting that therapies targeting the intermediary metabolism might improve treatment outcome.

  20. Preliminary Results of Field Emission Cathode Tests

    NASA Technical Reports Server (NTRS)

    Sovey, James S.; Kovaleski, Scott D.

    2001-01-01

    Preliminary screening tests of field emission cathodes such as chemical vapor deposited (CVD) diamond, textured pyrolytic graphite, and textured copper were conducted at background pressures typical of electric thruster test facilities to assess cathode performance and stability. Very low power electric thrusters which provide tens to hundreds micronewtons of thrust may need field emission neutralizers that have a capability of tens to hundreds of microamperes. From current voltage characteristics, it was found that the CVD diamond and textured metals cathodes clearly satisfied the Fowler-Nordheim emission relation. The CVD diamond and a textured copper cathode had average current densities of 270 and 380 mA/sq cm, respectively, at the beginning-of-life. After a few hours of operation the cathode emission currents degraded by 40 to 75% at background pressures in the 10(exp -5) Pa to 10(exp -4) Pa range. The textured pyrolytic graphite had a modest current density at beginning-of-life of 84 mA/sq cm, but this cathode was the most stable of all. Extended testing of the most promising cathodes is warranted to determine if current degradation is a burn-in effect or whether it is a long-term degradation process. Preliminary experiments with ferroelectric emission cathodes, which are ceramics with spontaneous electric polarization, were conducted. Peak current densities of 30 to 120 mA/sq cm were obtained for pulse durations of about 500 ns in the 10(exp -4) Pa pressure range.

  1. Results of immediate loading for implant restoration in partially edentulous patients: a 6-month preliminary prospective study using SinusQuick™ EB implant system

    PubMed Central

    Kim, Jong-Hwa; Kim, Young-Kyun; Yi, Yang-Jin; Yun, Pil-Young; Lee, Hyo-Jung; Kim, Myung-Jin

    2009-01-01

    STATEMENT OF PROBLEM Many dental clinicians are concerned about immediate loading of inserted implants. However, there have been few clinical studies surveying the success rates of immediate loading, based on Korean implant systems. PURPOSE The aim of this study was to evaluate the outcome of immediate functional loading of the implant (SinusQuick™ EB, Neobiotech Co., Seoul, Korea) in partially edentulous maxilla or mandible. MATERIAL AND METHODS Total 15 implants were placed. Within 2 weeks after implant insertion, provisional implant-supported fixed partial dentures were delivered to the patients. Quantitatively, marginal bone loss was measured at the time of immediate loading, after 3-months of continued loading and at the last follow-up. The mean follow-up period was 4.8 months. RESULTS Mean marginal bone loss from implant surgery to early loading, 3-months follow-up and last follow-up was 0.03 ± 0.07 mm, 0.16 ± 0.17 mm and 0.29 ± 0.19 mm. No implant failed up to 6 months after insertion, resulting in a 100% survival rate. CONCLUSION Immediate loading exhibited high success rate in partial edentulism for up to 6 months. Well-controlled long term clinical studies with large sample size are necessary to confirm this finding. PMID:21165269

  2. Preliminary results of a phase I/II trial of paclitaxel in patients with relapsed or cisplatin-refractory testicular cancer.

    PubMed

    Bokemeyer, C; Schmoll, H J; Natt, F; Knoche, M; Beyer, J; Souchon, R

    1994-01-01

    Paclitaxel represents a novel antitumour agent with demonstrated activity in cisplatin-sensitive tumours, particularly ovarian cancer. In addition, responses to paclitaxel have been observed in patients with cisplatin-refractory ovarian cancer. The role of paclitaxel in the treatment of testicular cancer has not been explored so far. Despite the generally high cure rates in patients with metastatic testicular cancer, patients with relapsed disease not responding to platin-based salvage chemotherapy have an extremely poor prognosis. In a phase I/II trial 10 patients with relapsed, cisplatin-refractory malignant germ-cell tumours were treated with paclitaxel as 6-h infusions (8 patients) or 3-h infusions (2 patients) at doses from 135 mg/m2 to 310 mg/m2 at 3-week intervals. Three patients achieved a response to paclitaxel, but disease recurred shortly in two patients after two and four cycles of therapy, respectively. One patient has remained in marker-negative partial response for more than 5 months. The toxicity of paclitaxel was tolerable for a dose range from 135 mg/m2 to 225 mg/m2. Granulocytopenia, WHO grades 3 and 4, occurred in all patients but was of short duration (median 3 days; range: 2-7 days). Other toxicities such as mucositis (5 patients grade 1), neurotoxicity (1 patient grade 1, 2 patients grade 2), infection (1 patient grade 3) and diarrhoea (1 patient grade 2) were not dose-limiting. There were no hypersensitivity reactions, but 1 patient developed severe myalgias during therapy with paclitaxel. Six patients with documented cisplatin-refractory disease were retreated with cisplatin-based chemotherapy after paclitaxel treatment and, in 4 of these, tumour responses of 3, 4, 5 and more than 5 months duration were achieved. In order to explore the role of paclitaxel in relapsed and/or cisplatin-refractory testicular cancer a phase II study using a 3-h infusion of 225 mg/m2 paclitaxel every 3 weeks, conducted by the German Testicular Cancer Study Group

  3. Endobronchial sonography: feasibility and preliminary results.

    PubMed Central

    Hürter, T; Hanrath, P

    1992-01-01

    Endobronchial sonography, a new ultrasound technique, has been evaluated for the assessment of normal lungs and bronchial carcinomas. The procedure was performed with ultrasound catheters, which were introduced into central and peripheral bronchi through the operating channel of fibreoptic bronchoscopes. The bronchial wall is highly echogenic and laminated. The lung parenchyma appears echo rich and patchy. Pulmonary arteries can be identified by the pulsatile changes and floating echoes within the echo free lumen. Echo poor bronchial carcinomas were detected in 69 out of 74 patients with endoscopically visible tumours and in 19 out of 26 patients with peripheral carcinomas. The correct implantation of metallic stents was facilitated by endobronchial sonography in nine patients. The sonographic examination carried no particular risk and caused little discomfort. Images PMID:1412103

  4. PRELIMINARY RESULTS FROM THE METIS-NEWDEAL® TOTAL METATARSOPHALANGEAL PROSTHESIS

    PubMed Central

    Silva, Luís Fernando Nunes Pires; Sousa, Cristina Varino; Pinto, Ricardo Rodrigues; Santos, Claudia; Geada, José Muras

    2015-01-01

    Objective: To evaluate the preliminary results from the METIS-Newdeal® metatarsophalangeal prosthesis for treating hallux rigidus grade III/IV. Methods: This was a prospective study on eight metatarsophalangeal prostheses that were placed in six patients between November 2007 and July 2009. The patients' mean age was 55 years and the mean follow-up after the surgery was 50 weeks. The results were evaluated using the AOFAS-MTP score and x-ray images as controls. Results: The AOFAS-MTP score increased significantly from 42p before the surgery to 82p after the surgery (↑ 1.95x), mainly due to improvement in the functional level. No intercurrences were identified radiologically. Among the five patients who underwent operations, only one expressed dissatisfaction with the surgery: this was expressed after early infection appeared at the surgical site, and it was the only postoperative complication found. Conclusion: Total metatarsophalangeal arthroplasty using METIS-Newdeal® presented promising short-term results. However, evaluations on a larger number of cases with a longer follow-up are needed in order to draw more consistent conclusions. PMID:27027011

  5. In-vivo Axial-strain Sonoelastography Helps Distinguish Acutely-inflamed from Fibrotic Terminal Ileum Strictures in Patients with Crohn's Disease: Preliminary Results.

    PubMed

    Sconfienza, Luca Maria; Cavallaro, Flaminia; Colombi, Valentino; Pastorelli, Luca; Tontini, Gianeugenio; Pescatori, Lorenzo; Esseridou, Anastassia; Savarino, Edoardo; Messina, Carmelo; Casale, Roberto; Di Leo, Giovanni; Sardanelli, Francesco; Vecchi, Maurizio

    2016-04-01

    We tested real-time sonoelastography (RTS) in-vivo to differentiate fibrotic from inflammatory terminal ileum strictures in patients with Crohn's disease (CD), using magnetic resonance enterography (MRE) as a reference standard. Sixteen patients (13 male, 3 female; median [interquartile interval] age = 41 [31-48.5] y; median C-reactive protein (CRP) = 0.95 [0-2.23] mg/dL; median disease duration = 108.5 [35-213.75] mo; median Harvey-Bradshaw Index (HBI) = 3 [3-5.25]) with terminal ileum CD were prospectively included. Short-axis scans were performed; each cross-section was ideally sub-divided into eight circular sectors. Color map provided by RTS was translated into semi-quantitative scale (1 = red; 2 = green; 3 = blue). At MRE, inflammation was seen in nine patients and fibrosis in seven. Total median RTS score was significantly lower in patients with inflammatory stricture (16 [16-18]) than in patients with fibrosis (20 [17.5-22]; p = 0.003). The same happened when the four most superficial quadrants of the loop were considered (8 [7-9] vs. 10 [9-11.5]; p = 0.003). No significant correlation was seen between RTS and HBI (r = 0.467; p = 0.686), RTS and CRP (r = -0.750; p = 0.567) or RTS and disease duration (r = 0.238; p = 0.483). RTS of the terminal ileum in patients with CD is feasible in-vivo, potentially differentiating between fibrotic and inflammatory strictures. PMID:26742896

  6. Earth Radiation Budget Experiment - Preliminary seasonal results

    NASA Technical Reports Server (NTRS)

    Barkstrom, Bruce R.; Harrison, Edwin F.; Lee, Robert B., III

    1990-01-01

    Data from the Earth Radiation Budget Satellite (ERBS) and from the operational NOAA-9 satellite being placed in the archive of the earth Radiation Budget Experiment (ERBE) are discussed. The results of the ERBE data validation effort are reviewed along with ERBE solar constant observations and earth-viewing results. The latter include monthly average results for July 1985, annual average clear-sky fluxes, and annual average, zonal, and global results.

  7. Acute effects of light emitting diodes therapy (LEDT) in muscle function during isometric exercise in patients with chronic obstructive pulmonary disease: preliminary results of a randomized controlled trial.

    PubMed

    Miranda, Eduardo Foschini; Leal-Junior, Ernesto Cesar Pinto; Marchetti, Paulo Henrique; Dal Corso, Simone

    2014-01-01

    Patients with chronic obstructive pulmonary disease (COPD) are susceptible to early muscle fatigue. Light-emitting diodes therapy (LEDT) has been used to minimize muscle fatigue in athletes and healthy subjects. The aim of this study is to investigate the acute effects of LEDT on muscle fatigue and perception of effort in patients with COPD during isometric endurance test of the quadriceps femoris (QF). Ten patients (VEF₁ 50 ± 13% of predicted) underwent a single LEDT and sham application, 48 h apart, in a randomized crossover design. The LEDT and sham were applied in three localized areas of the QF (rectus femoris, vastus lateralis, and vastus medialis). Before and after exposure to LEDT and sham, the patients performed an isometric endurance test (60 % of the maximum voluntary isometric contraction), until the limit of tolerance concomitant to surface electromyography recording (median frequency as mean outcome). The slope obtained from linear regression analysis of the median frequency (MF) over endurance time was also used as an endurance index. Endurance time increased significantly after exposure to LEDT (from 26 ± 2 to 53 ± 5 s) as compared to sham (from 23 ± 3 to 30 ± 4 s) (F = 64, P = 0.0001). A greater decline in MF was observed during isometric endurance test after sham, compared to LEDT (F = 14.6, P = 0.004). The slope of the MF over time was lower post-LEDT compared to post-sham (-0.7 ± 0.3 vs. -1.5 ± 0.8; P = 0.004). The dyspnea score corrected for endurance time was lower post-LEDT (P = 0.008) but similar for fatigue both post-LEDT and post-sham. A single application of LEDT minimizes muscle fatigue and increases isometric endurance time. PMID:23743817

  8. AI gamma-ray burst classification: Methodology/preliminary results

    NASA Astrophysics Data System (ADS)

    Hakkila, Jon; Haglin, David J.; Roiger, Richard J.; Mallozzi, Robert S.; Pendleton, Geoffrey N.; Meegan, Charles A.

    1998-05-01

    Artificial intelligence (AI) classifiers can be used to classify unknowns, refine existing classification parameters, and identify/screen-out ineffectual parameters. We present an AI methodology for classifying gamma-ray bursts, along with some preliminary results.

  9. Preliminary Silver-hydrogen Cell Test Results

    NASA Technical Reports Server (NTRS)

    Lurie, C.

    1984-01-01

    Silver-hydrogen cells were tested. The objective of the test was to estimate useful life by operation at accelerated, simulated geosynchronous orbit conditions. Ten simulated seasons were run and are summarized. The results to-date reflect stable, trouble-free performance and indicate that the silver-hydrogen couple shows promise as a lightweight alternative to the nickel systems.

  10. PRELIMINARY RESULTS OF STRAWBERRY FUNGICIDE STUDY

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Thirteen fungicide treatments were evaluated for their disease control efficacy on the strawberry cultivar Camarosa at the Hammond Research Station, Hammond, LA during the 2002 fruiting season. Significant differences in yield occurred as a result of fungicide treatments. Highest yield was recorde...

  11. Preliminary results of steel containment vessel model test

    SciTech Connect

    Luk, V.K.; Hessheimer, M.F.; Matsumoto, T.; Komine, K.; Arai, S.; Costello, J.F.

    1998-04-01

    A high pressure test of a mixed-scaled model (1:10 in geometry and 1:4 in shell thickness) of a steel containment vessel (SCV), representing an improved boiling water reactor (BWR) Mark II containment, was conducted on December 11--12, 1996 at Sandia National Laboratories. This paper describes the preliminary results of the high pressure test. In addition, the preliminary post-test measurement data and the preliminary comparison of test data with pretest analysis predictions are also presented.

  12. Preliminary results of steel containment vessel model test

    SciTech Connect

    Matsumoto, T.; Komine, K.; Arai, S.

    1997-04-01

    A high pressure test of a mixed-scaled model (1:10 in geometry and 1:4 in shell thickness) of a steel containment vessel (SCV), representing an improved boiling water reactor (BWR) Mark II containment, was conducted on December 11-12, 1996 at Sandia National Laboratories. This paper describes the preliminary results of the high pressure test. In addition, the preliminary post-test measurement data and the preliminary comparison of test data with pretest analysis predictions are also presented.

  13. Medical Radioisotope Data Survey: 2002 Preliminary Results

    SciTech Connect

    Siciliano, Edward R.

    2004-06-23

    A limited, but accurate amount of detailed information about the radioactive isotopes used in the U.S. for medical procedures was collected from a local hospital and from a recent report on the U.S. Radiopharmaceutical Markets. These data included the total number of procedures, the specific types of procedures, the specific radioisotopes used in these procedures, and the dosage administered per procedure. The information from these sources was compiled, assessed, pruned, and then merged into a single, comprehensive and consistent set of results presented in this report. (PIET-43471-TM-197)

  14. Viking magnetic properties investigation: preliminary results.

    PubMed

    Hargraves, R B; Collinson, D W; Spitzer, C R

    1976-10-01

    Three permanent magnet arrays are aboard the Viking lander. By sol 35, one array, fixed on a photometric reference test chart on top of the lander, has clearly attracted magnetic particles from airborne dust; two other magnet arrays, one strong and one weak, incorporated in the backhoe of the surface sampler, have both extracted considerable magnetic mineral from the surface as a result of nine insertions associated with sample acquisition. The loose martian surface material around the landing site is judged to contain 3 to 7 percent highly magnetic mineral which, pending spectrophotometric study, is thought to be mainly magnetite. PMID:17793086

  15. Viking magnetic properties investigation - Preliminary results

    NASA Technical Reports Server (NTRS)

    Hargraves, R. B.; Collinson, D. W.; Spitzer, C. R.

    1976-01-01

    Three permanent-magnet arrays are aboard the Viking lander. By sol 35, one array, fixed on a photometric reference test chart on top of the lander, has clearly attracted magnetic particles from airborne dust; two other magnet arrays, one strong and one weak, incorporated in the backhoe of the surface sampler, have both extracted considerable magnetic mineral from the surface as a result of nine insertions associated with sample acquisition. The loose Martian surface material around the landing site is judged to contain 3 to 7 per cent highly magnetic mineral which, pending spectrophotometric study, is thought to be mainly magnetite.

  16. Use of a capillary input function with cardiac output for the estimation of lesion pharmacokinetic parameters: preliminary results on a breast cancer patient

    NASA Astrophysics Data System (ADS)

    Di Giovanni, P.; Ahearn, T. S.; Semple, S. I.; Azlan, C. A.; Lloyd, W. K. C.; Gilbert, F. J.; Redpath, T. W.

    2011-03-01

    The objective of this work was to propose and demonstrate a novel technique for the assessment of tumour pharmacokinetic parameters together with a regionally estimated vascular input function. A breast cancer patient T2*-weighted dynamic contrast enhanced MRI (DCE-MRI) dataset acquired at high temporal resolution during the first-pass bolus perfusion was used for testing the technique. Extraction of the lesion volume transfer constant Ktrans together with the intravascular plasma volume fraction vp was achieved by optimizing a capillary input function with a measure of cardiac output using the principle of intravascular indicator dilution theory. For a region of interest drawn within the breast lesion a vp of 0.16 and a Ktrans of 0.70 min-1 were estimated. Despite the value of vp being higher than expected, estimated Ktrans was in accordance with the literature values. In conclusion, the technique proposed here, has the main advantage of allowing the estimation of breast tumour pharmacokinetic parameters from first-pass perfusion T2*-weighted DCE-MRI data without the need of measuring an arterial input function. The technique may also have applicability to T1-weighted DCE-MRI data.

  17. Preliminary results of a PACS implementation

    NASA Astrophysics Data System (ADS)

    Kishore, Sheel; Khalsa, Satjeet S.; Seshadri, Sridhar B.; Arenson, Ronald L.

    1991-07-01

    The Radiology Department at the University of Pennsylvania is in the process of clinically testing the first phase of its PACS implementation. The first phase has been designed to support two Intensive Care Units, two GE SIGNA MR units and a Du Pont FD 2000 Film Digitizer. The entire system has been running clinically for about three months. Any PACS effort involves integrating software and hardware from different manufactures. Some of the equipment on a PACS network are often 'closed' and provide limited access. In addition, the entire PACS system is expected to provide uninterrupted service, have adequate throughput and ensure data integrity. By and large, these goals have been met. Clinical testing has provided valuable insights about system integration and highlighted areas of improvement in the system design. A detailed discussion of these results is presented.

  18. Modelling Extortion Racket Systems: Preliminary Results

    NASA Astrophysics Data System (ADS)

    Nardin, Luis G.; Andrighetto, Giulia; Székely, Áron; Conte, Rosaria

    Mafias are highly powerful and deeply entrenched organised criminal groups that cause both economic and social damage. Overcoming, or at least limiting, their harmful effects is a societally beneficial objective, which renders its dynamics understanding an objective of both scientific and political interests. We propose an agent-based simulation model aimed at understanding how independent and combined effects of legal and social norm-based processes help to counter mafias. Our results show that legal processes are effective in directly countering mafias by reducing their activities and changing the behaviour of the rest of population, yet they are not able to change people's mind-set that renders the change fragile. When combined with social norm-based processes, however, people's mind-set shifts towards a culture of legality rendering the observed behaviour resilient to change.

  19. Inverse synthetic aperture radar: Preliminary results

    NASA Astrophysics Data System (ADS)

    Eerland, K. K.

    1982-06-01

    Theory and results of simulations, associated with inverse synthetic aperture radar (ISAR) imaging are discussed. A radar signal processing algorithm was developed which derives an ISAR image of an aircraft model. This algorithm assumes a straight unaccelerated flight path and an accurate measurement of the flight path parameters in order to perform proper imaging. However, in practice an aircraft may be maneuvering during the observation and also some flight path parameters may be measured in-accurately. In order to compensate for the two most frequent disturbing effects, the algorithm makes use of two specific correction methods. First, a measurement error in the target velocity is removed by means of an optimization procedure and, secondly, a compensation for a curved flight path is performed. Attention is also given to the influence of observation noise. The noise is assumed to be stationary, Gaussian and white (a uniform spectrum).

  20. The CLU Nearby Galaxy Catalog: Preliminary Results

    NASA Astrophysics Data System (ADS)

    Cook, David O.; Kasliwal, Mansi M.; iPTF

    2016-01-01

    The intermediate Palomar Transient Factory (iPTF) has been undertaking the Census of the Local Universe (CLU) project to complete our survey of galaxies out to 200 Mpc. CLU deploys four contiguous narrow-band filters to search for extended, emission line (Hα) sources across 3π of the sky. The estimated 5σ limiting flux for a point source is 2×10-17 erg s-1 cm-2 (Rau et al., 2009), which corresponds to a star formation rate (SFR) of 10-3 M⊙ yr-1 at a distance of 200 Mpc. Thus, the CLU galaxy catalog will capture 85% of the B-band light and 92% of the Hα luminosity out to 200 Mpc resulting in tens-of-thousands of newly discovered galaxies. We present the narrowband imaging characteristics, the criteria used for selecting galaxy candidates, and a sub-set of newly discovered galaxies that have been spectroscopically confirmed.

  1. Emetophobia: preliminary results of an internet survey.

    PubMed

    Lipsitz, J D; Fyer, A J; Paterniti, A; Klein, D F

    2001-01-01

    Through electronic mail, we surveyed members of an internet support group for emetophobia (fear of vomiting). Respondents were 50 women and 6 men with a mean age of 31 years. Results suggest that, for this sample, emetophobia is a disorder of early onset and chronic course, with highly persistent and intrusive symptoms. Emetophobia is implicated in social, home-marital, and occupational impairment and it causes significant constriction of leisure activities. Nearly half of women avoided or delayed becoming pregnant. About three quarters of respondents have eating rituals or significantly limit the foods they eat. Respondents describe other problems such as depression, panic attacks, social anxiety, compulsions, and frequent history of childhood separation anxiety. PMID:11668669

  2. Computerized Script Training for Aphasia: Preliminary Results

    PubMed Central

    Cherney, Leora R.; Halper, Anita S.; Holland, Audrey L.; Cole, Ron

    2009-01-01

    Purpose This article describes computer software that was developed specifically for training conversational scripts and illustrates its use with three individuals with aphasia. Methods Three participants with chronic aphasia (Broca’s, Wernicke’s and anomic) were assessed before and after nine weeks of a computer script training program. For each participant, three individualized scripts were developed, recorded on the software, and practiced sequentially at home. Weekly meetings with the speech-language pathologist occurred to monitor practice and assess progress. Baseline and post-treatment scripts were audio-taped, transcribed, and compared to the target scripts for content, grammatical productivity and rate of production of script-related words. Interviews with the person with aphasia and their significant other were conducted at the conclusion of treatment. Results All measures (content, grammatical productivity and rate of production of script-related words) improved for each participant on every script. Two participants gained more than five points on the Aphasia Quotient of the Western Aphasia Battery. Five positive themes were consistently identified from the exit interviews - increased verbal communication, improvements in other modalities and situations, communication changes noticed by others, increased confidence, and satisfaction with the software. Conclusion Computer-based script training potentially may be an effective intervention for persons with chronic aphasia. PMID:18230811

  3. Preliminary Results of Solid Gas Generator Micropropulsion

    NASA Technical Reports Server (NTRS)

    deGroot, Wilhelmus A.; Reed, Brian D.; Brenizer, Marshall

    1999-01-01

    A decomposing solid thruster concept, which creates a more benign thermal and chemical environment than solid propellant combustion, while maintaining, performance similar to solid combustion, is described. A Micro-Electro-Mechanical (MEMS) thruster concept with diode laser and fiber-optic initiation is proposed, and thruster components fabricated with MEMS technology are presented. A high nitrogen content solid gas generator compound is evaluated and tested in a conventional axisymmetric thrust chamber with nozzle throat area ratio of 100. Results show incomplete decomposition of this compound in both low pressure (1 kPa) and high pressure (1 MPa) environments, with decomposition of up to 80% of the original mass. Chamber pressures of 1.1 MPa were obtained, with maximum calculated thrust of approximately 2.7 N. Resistively heated wires and resistively heated walls were used to initiate decomposition. Initiation tests using available lasers were unsuccessful, but infrared spectra of the compound show that the laser initiation tests used inappropriate wavelengths for optimal propellant absorption. Optimal wavelengths for laser ignition were identified. Data presented are from tests currently in progress. Alternative solid gas generator compounds are being evaluated for future tests.

  4. Preliminary Results From the Champ Occultation Measurements

    NASA Astrophysics Data System (ADS)

    Hajj, G.; Dong, D.; Iijima, B.; Kuang, D.; Kursinski, R.; Mannucci, A.; Meehan, T.; Romans, L.; de la Torre Juárez, M.; Yunck, T.

    2001-05-01

    Champ collects 200-250 globally distributed GPS occultations every day providing a wealth of information on atmospheric parameters such as pressure, temperature, humidity between 0-60 km altitude and electron density above 60 km altitude. There are several aspects to the Champ occultation measurements which distinguish them from prior measurements (such as from GPS/MET, Oersted and SAC-C): (1) They are taken during solar maximum; (2) they are collected with a new generation receiver ("BlackJack") which provides high quality L1 and L2 measurements even when the DoD anti-spoofing of the GPS signal is turned on; (3) the tracking loop in the receiver is optimized to allow the occulted signal to descend very low in the atmosphere (<1km from the surface). A further distinction comes from the fact that selective availability (the dithering of the GPS clocks) was permanently turned off by DoD, therefore reducing or eliminating the need for 1-second ground measurements previously used to difference out high frequency GPS clock drifts. This talk will present results obtained at JPL from the early Champ occultation data sets, first collected in February, 2001, and will address the specific issues listed above. Specifically, we will present (a) statistics on how low in the atmosphere occultations are able to probe as a function of geographical latitudes and humidity conditions; (b) the limitations on higher altitude atmospheric retrievals (between 30-60 km) caused by the ionosphere at different local times and solar conditions, including comparisons to GPS/MET data taken during solar minimum; (c) individual and statistical comparisons of temperature and water vapor to atmospheric analyses such as NCEP and ECMWF and other data sets such as radiosondes; (d) the impact of including or excluding high rate ground data.

  5. Breast tomography with synchrotron radiation: preliminary results

    NASA Astrophysics Data System (ADS)

    Pani, Silvia; Longo, Renata; Dreossi, Diego; Montanari, Francesco; Olivo, Alessandro; Arfelli, Fulvia; Bergamaschi, Anna; Poropat, Paolo; Rigon, Luigi; Zanconati, Fabrizio; Dalla Palma, Ludovico; Castelli, Edoardo

    2004-05-01

    A system for in vivo breast imaging with monochromatic x-rays has been designed and built at the synchrotron radiation facility Elettra in Trieste (Italy) and will be operational in 2004. The system design involves the possibility of performing both planar mammography and breast tomography. In the present work, the first results obtained with a test set-up for breast tomography are shown and discussed. Tomographic images of in vitro breasts were acquired using monochromatic x-ray beams in the energy range 20-28 keV and a linear array silicon pixel detector. Tomograms were reconstructed using standard filtered backprojection algorithms; the effect of different filters was evaluated. The attenuation coefficients of fibroglandular and adipose tissue were measured, and a quantitative comparison of images acquired at different energies was performed by calculating the differential signal-to-noise ratio of fibroglandular details in adipose tissue. All images required a dose comparable to the dose delivered in clinical, conventional mammography and showed a high resolution of the breast structures without the overlapping effects that limit the visibility of the structures in 2D mammography. A quantitative evaluation of the images proves that the image quality at a given dose increases in the considered energy range and for the considered breast sizes. This work is dedicated to the memory of Paolo Poropat, who died tragically on June 8th, 2002. He was a brilliant experimental scientist and gave relevant contributions to the fields of high energy physics and medical physics. He had a very rich and versatile personality, a brilliant character, a big vitality. We will never forget him, his love of life, the passion and the enthusiasm he put into everything he did.

  6. Preliminary Results of Bisphosphonate ISS Flight Experiment

    NASA Technical Reports Server (NTRS)

    LeBlanc, Adrian; Jones, Jeff; Shapiro, Jay; Lang, Tom; Shackelford, Linda C.; Smith, Scott M.; Evans, Harlan J.; Spector, Elisabeth R.; Sibonga, Jean; Matsumoti, Toshio; Nakamura, Toshitaka; Kohri, Kenjiro; Ohshima, Hiroshi

    2010-01-01

    Bone loss has been recognized as a potential problem from the beginning of human spaceflight. With the spaceflight missions lasting 6 months to potentially 3 years or longer this issue has assumed increased significance. Detailed measurements from the Mir and ISS long duration missions have documented losses in bone mineral density (BMD) from the total skeleton and critical sub-regions. The most important losses are from the femoral hip averaging about -1.6%/mo integral to -2.3%/mo trabecular BMD. Importantly these studies have documented the wide range in individual response from -0.5 to -5%/mo in BMD. Given the small size of any expedition crew, the wide range of responses has to be considered in the implementation of any countermeasure. Assuming that it is unlikely that the susceptibility for bone loss in any given crewmember will be known, a suite of bone loss countermeasures will likely be needed to insure protection of all crewmembers. The hypothesis for this experiment is that the combined effect of anti-resorptive drugs plus the standard in-flight exercise regimen will have a measurable effect on preventing space flight induced bone loss and strength and will reduce renal stone risk. To date, 4 crewmembers have completed the flight portion of the protocol in which crewmembers take a 70-mg alendronate tablet once a week before and during flight, starting 17 days before launch. Compared to previous ISS crewmembers (n=14) not taking alendronate, DXA measurements of the total hip BMD were significantly changed from -1.1 0.5%/mo to 0.04 0.3%/mo (p<0.01); QCT-determined trabecular BMD of the total hip was significantly changed from -2.3 1.0%/mo to -0.3 1.6%/mo (p<0.01). Significance was calculated from a one-tailed t test. While these results are encouraging, the current n (4) is small, and the large SDs indicate that while the means are improved there is still high variability in individual response. Four additional crewmembers have been recruited to participate

  7. Intraarterial Ultrasound in Pancreatic Cancer: Feasibility Study and Preliminary Results

    SciTech Connect

    Larena-Avellaneda, Axel; Timm, Stephan; Kickuth, Ralph; Kenn, Werner; Steger, Ulrich; Jurowich, Christian; Germer, Christoph-Thomas

    2010-08-15

    Despite technological advances in computed tomography (CT) and magnetic resonance imaging, the involvement of the celiac or mesenteric artery in pancreatic cancer remains uncertain in many cases. Infiltration of these vessels is important in making decisions about therapy choices but often can only be definitively determined through laparotomy. Local (intraarterial) ultrasound may increase diagnostic accuracy. Using the Volcano intravascular ultrasound (IVUS) system, we applied a transfemoral method to scan the celiac and mesenteric arteries directly intraarterial. This technique was used in five patients with suspected pancreatic cancer. Technical success was achieved in all cases. In one case, a short dissection of the mesenteric artery occurred but could be managed interventionally. In tumors that did not contact with the vessels, IVUS was unable to display the tissue pathology. Our main interest was the infiltration of the arteries. In one case, infiltration was certain in the CT scan but uncertain in two patients. In the latter two cases, IVUS correctly predicted infiltration in one and freedom from tumor in the other case. In our preliminary study, IVUS correctly predicted arterial infiltration in all cases. IVUS did not provide new information when the tumor was far away from the vessel. Compared with IVUS in the portal vein, the information about the artery is more detailed, and the vessel approach is easier. These results encouraged us to design a prospective study to evaluate the sensitivity and specificity of this method.

  8. In situ photoimmunotherapy for melanoma: preliminary clinical results

    NASA Astrophysics Data System (ADS)

    Naylor, Mark F.; Nordquist, Robert E.; Teauge, T. Kent; Perry, Lisa A.; Chen, Wei R.

    2006-02-01

    Although melanoma accounts for only 4% of skin cancer cases, it causes 79% of all skin cancer deaths. Patients with metastatic melanoma have a poor prognosis, and long term survival is only about 5% [1, 2]. Conventional therapies such as surgery and radiation therapy usually do not cure stage III or stage IV melanoma, while traditional chemotherapy is primarily palliative. Over the last decade we have been developing new methods for treating solid tumors like melanoma, first in animal models and now in humans. We present here preliminary results from a new technique that utilizes a combination of laser stimulation and drug therapy to stimulate brisk immunological responses in cases of advanced melanoma with cutaneous metastases. A high-power, near-infrared diode laser (805 nm) is used to kill tumors in situ and a topical toll-like receptor agonist (imiquimod cream, 5%) is used to intensify the resulting immunological response. This is essentially an in situ, tumor vaccine approach to treating solid tumors.

  9. [Neonatal pilonidal sinuses and screening by medullary ultrasonography: preliminary results].

    PubMed

    Avni, E F; Matos, C; Grassart, A; Christophe, C; Pardou, A; Baleriaux, D

    1991-01-01

    The authors report on their preliminary experience with ultrasound as a screening examination in neonates presenting pilonidal sinuses. Of the 100 patients examined over the 2 previous years, three pathological cases were found (1 tethered cord, 1 lipoma of the filum terminale and one localized hydromelia). Abnormal or doubtful cases were confirmed or further investigated by magnetic resonance. Ultrasound seems to be an accurate technique for the detection of malformation of spinal canal content in neonates under one month of age. PMID:1660120

  10. Connecticut Transit (CTTRANSIT) Fuel Cell Transit Bus: Preliminary Evaluation Results

    SciTech Connect

    Chandler, K.; Eudy, L.

    2008-10-01

    This report provides preliminary results from a National Renewable Energy Laboratory evaluation of a protoptye fuel cell transit bus operating at Connecticut Transit in Hartford. Included are descriptions of the planned fuel cell bus demonstration and equipment; early results and agency experience are also provided.

  11. Hydrogen-burn survival: preliminary thermal model and test results

    SciTech Connect

    McCulloch, W.H.; Ratzel, A.C.; Kempka, S.N.; Furgal, D.T.; Aragon, J.J.

    1982-08-01

    This report documents preliminary Hydrogen Burn Survival (HBS) Program experimental and analytical work conducted through February 1982. The effects of hydrogen deflagrations on safety-related equipment in nuclear power plant containment buildings are considered. Preliminary results from hydrogen deflagration experiments in the Sandia Variable Geometry Experimental System (VGES) are presented and analytical predictions for these tests are compared and discussed. Analytical estimates of component thermal responses to hydrogen deflagrations in the upper and lower compartments of an ice condenser, pressurized water reactor are also presented.

  12. Preliminary Results of the 1979 Doctorate Employment Survey.

    ERIC Educational Resources Information Center

    Stapp, Joy; Fulcher, Robert

    Preliminary results of the 1979 Doctorate Employment Survey, which is designed to assess the employment experiences of new doctorates in psychology, are briefly described. The survey focuses on employment status, employment settings, and salaries, and is the first survey designed to allow respondents to provide detailed information on their…

  13. Preliminary Investigation of Economics Issues in Hospitalized Patients with Stroke

    PubMed Central

    Tolou-Ghamari, Zahra; Shaygannejad, Vahid; Khorvash, Fariborz

    2013-01-01

    Background: The study of economics is important in Iranian stroke patients, because it is one of the costly diseases that could be linked to disability, mortality, and morbidity. The aim of this preliminary study was to investigate total treatment costs of hospitalized patients with stroke. Methods: A cross-sectional study of 24 patients conducted to Isfahan Neurosciences Research Centre was carried out between April 1, 2012 and September 31, 2012. Demographic (sex, age) and economic variables (Raise tariffs, accumulated surplus, the total amount, of patients’, patients’ paid, and home insurance contribution) were extracted from the patients’ profiles. All information recorded and processed using Excel. Results: The mean age of patients was 71 years (ranged; 40-93 years old). Preliminary analysis of available costs issues could be described as: Raise tariffs (mean: 3500256 Rial, ranged: 504460-9775455 Rial), accumulated surplus (mean: 565578 Rial, ranged: 56700-2343664 Rial), the total amount (mean: 4045556 Rial, ranged: 715460-12219119 Rial), of patients’ (mean: 756037 Rial, ranged: 0-8365447 Rial), patients’ paid (mean: 1307762 Rial, ranged: 45300-9193000 Rial), and home insurance contribution (mean: 3070713 Rial, ranged 0-8887907 Rial). Conclusions: The cost disparity within this study after stroke could be mainly connected to variations in duration of hospital stay. Inspecting agenda towards this direction could reduce the economic cost of stroke significantly. Therefore, further assessment correlated to attain strategies in order to reduce costs associated to patients’ paid and home insurance contribution could be much more advantageous. PMID:23776748

  14. Hellenic Amateur Astronomy Association's activities: Preliminary results on Perseids 2010

    NASA Astrophysics Data System (ADS)

    Maravelias, G.

    2011-01-01

    Preliminary results on the Perseids 2010 are presented. Visual and video observations were obtained by the author and a first reduction of the visual data shows that a maximum of ZHR ~120 was reached during the night 12-13 of August 2010. Moreover, a video setup was tested (DMK camera and UFO Capture v2) and the results show that, under some limitations, valuable data can be obtained.

  15. Preliminary Simulation Results of the 23 June, 2001 Peruvian Tsunami

    NASA Astrophysics Data System (ADS)

    Titov, V. V.; Koshimura, S.; Ortiz, M.; Borrero, J.

    2001-12-01

    The tsunami generated by the June 23, 2001 Peruvian earthquake devastated a 50--km section of coast near the earthquake epicenter and was recorded on tide-gages throughout the Pacific. The coastal town of Camana sustained the most damage with tsunami waves penetrating up to 1--km inland and runup exceeding 5--m. The extreme local effects and widespread impact motivated modeling efforts to produce a realistic tsunami simulation of this event. Preliminary results were produced by the TIME center using two resident numerical models, TUNAMI--2 and MOST. Both models were used to produce preliminary simulations shortly after the earthquake, and first results were posted on the Internet a day after the event (http://www.pmel.noaa.gov/tsunami/peru_pmel.html). These numerical results aimed to quantify the magnitude of the tsunami and, to certain extent, to guide the post-tsunami survey. The first simulations have been revised using new data about the seismic source and the results of the post-tsunami survey. Measured inundation distances, flow depths, and runup along topographic transects are used to constrain the inundation model. Preliminary numerical analysis of tsunami inundation will be presented.

  16. Preliminary Results of the MOSES II 2015 Flight

    NASA Astrophysics Data System (ADS)

    Smart, Roy; Courrier, Hans; Kankelborg, Charles

    2016-05-01

    The Multi-Order Extreme Ultraviolet Spectrograph (MOSES) is a slitless spectrograph which aims to produce simultaneous spatial-spectral imaging of the solar transition region. This is accomplished through a multilayer concave diffraction grating which produces three images for the spectral orders m = 0, ± 1. The multilayer coating provides a narrow passband, dominated by Ne VII (46.5 nm), which allows the three images to be compared in order to determine line broadenings and identify explosive events in the Solar Transition Region. Here, we examine the preliminary results of MOSES II, the instrument’s second flight which was launched on a sounding rocket from White Sands Missile Range, NM in August 2015. We present the first images of the Sun in Ne VII since Skylab and the preliminary results of observed doppler shifts within an active region.

  17. Preliminary Langmuir probe results on the CTX gun experiment

    SciTech Connect

    Tuszewski, M.

    1981-12-01

    Preliminary results obtained with a double Langmuir probe in the Compact Toroid experiment facility confirm the existence of a gun plasma of n approx. 5 x 10/sup 14/ cm/sup -3/ and T approx. 10 eV lasting for approx. 250 to 400 ..mu..s, which is consistent with interferometry and Thomson scattering data. The probe current characteristics as a function of voltage suggest non-Maxwellian features of the particles distribution functions.

  18. Preliminary result of Indonesian strain map based on geodetic measurements

    NASA Astrophysics Data System (ADS)

    Susilo, Meilano, Irwan; Abidin, Hasanuddin Z.; Sapiie, Benyamin; Efendi, Joni; Wijanarto, Antonius B.

    2016-05-01

    GPS measurements from 1993 until 2014 across Indonesia region are providing longer time series at 2 - 3 millimetre-level precision from which surface velocity estimates are derived. In this study, we use this GPS velocities field to construct a crustal strain rate map and not including the physical model yet. In our preliminary result, we only compute the magnitude of the strain rate. The strain map is useful to construct the deformation model in Indonesia and to support the Indonesia datum.

  19. Preliminary results of the echo-seeding experiment at SLAC

    SciTech Connect

    Xiang, D.; Colby, E.; Ding, Y.; Dunning, M.; Frederico, J.; Gilevich, S.; Hast, C.; Jobe, K.; McCormick, D.; Nelson, J.; Raubenheimer, T.O.; Soong, K.; Stupakov, G.; Szalata, Z.; Walz, D.; Weathersby, S.; Woodley, M.; Corlett, J.; Qiang, J.; Penn, G.; Prestemon, S.; Schlueter, R.; Venturini, M.; Wan, W.; Pernet, P-L.

    2010-05-23

    ECHO-7 is a proof-of-principle echo-enabled harmonic generation FEL experiment in the Next Linear Collider Test Accelerator (NLCTA) at SLAC. The experiment aims to generate coherent radiation at 318 nm and 227 nm, which are the 5th and 7th harmonic of the infrared seed laser. In this paper we present the preliminary results from the commissioning run of the completed experimental setup which started in April 2010.

  20. Shoe-box orbit determination system for SMM preliminary results

    NASA Technical Reports Server (NTRS)

    Tasaki, K. K.; Goorevich, C.

    1979-01-01

    The implementation of both sequential and batch methods of estimation on IMP-16 microprocessors was investigated. Simulated data was used from a tracking and data relay satellite whose target satellite was the Solar Maximum Mission. An interesting feature of the hardware was the use of two interconnected IMP-16's. Some preliminary results from the study, as well as the difficulties and advantages in the use of microprocessors, are presented.

  1. Preliminary results of noncircular plasma experiments in Doublet III

    SciTech Connect

    Ohkawa, T.

    1980-02-01

    Preliminary results of noncircular plasma experiments in Doublet III are reported. Shaping and discharge characteristics in doublet plasmas with high-Z limiters are described. Electron energy confinement and maximum plasma density are in agreement with standard circular tokamak empirical scaling laws. Chromium and molybdenum appear to be the dominant high-Z contaminants while carbon appears to dominate low-Z contaminants. High-Z impurity radiation does not appear to dominate the central power balance.

  2. 9.4T Human MRI: Preliminary Results

    PubMed Central

    Vaughan, Thomas; DelaBarre, Lance; Snyder, Carl; Tian, Jinfeng; Akgun, Can; Shrivastava, Devashish; Liu, Wanzahn; Olson, Chris; Adriany, Gregor; Strupp, John; Andersen, Peter; Gopinath, Anand; van de Moortele, Pierre-Francois; Garwood, Michael; Ugurbil, Kamil

    2014-01-01

    This work reports the preliminary results of the first human images at the new high-field benchmark of 9.4T. A 65-cm-diameter bore magnet was used together with an asymmetric 40-cm-diameter head gradient and shim set. A multichannel transmission line (transverse electromagnetic (TEM)) head coil was driven by a programmable parallel transceiver to control the relative phase and magnitude of each channel independently. These new RF field control methods facilitated compensation for RF artifacts attributed to destructive interference patterns, in order to achieve homogeneous 9.4T head images or localize anatomic targets. Prior to FDA investigational device exemptions (IDEs) and internal review board (IRB)-approved human studies, preliminary RF safety studies were performed on porcine models. These data are reported together with exit interview results from the first 44 human volunteers. Although several points for improvement are discussed, the preliminary results demonstrate the feasibility of safe and successful human imaging at 9.4T. PMID:17075852

  3. Preliminary Results on Uncertainty Quantification for Pattern Analytics

    SciTech Connect

    Stracuzzi, David John; Brost, Randolph; Chen, Maximillian Gene; Malinas, Rebecca; Peterson, Matthew Gregor; Phillips, Cynthia A.; Robinson, David G.; Woodbridge, Diane

    2015-09-01

    This report summarizes preliminary research into uncertainty quantification for pattern ana- lytics within the context of the Pattern Analytics to Support High-Performance Exploitation and Reasoning (PANTHER) project. The primary focus of PANTHER was to make large quantities of remote sensing data searchable by analysts. The work described in this re- port adds nuance to both the initial data preparation steps and the search process. Search queries are transformed from does the specified pattern exist in the data? to how certain is the system that the returned results match the query? We show example results for both data processing and search, and discuss a number of possible improvements for each.

  4. Preliminary science results of Voyager 1 Saturn encounter

    NASA Technical Reports Server (NTRS)

    Bane, D.

    1981-01-01

    Preliminary science results of the Voyager 1 encounter of the planet Saturn are reported. On August 22, 1980, the spacecraft was 109 million km (68 million mi) from Saturn. Closest approach to Saturn took place on November 12, at 3:46 p.m. (PDT), when the spacecraft passed 126,000 km (78,000 mi) from the cloud tops. Measurements of the atmosphere, wind speed, radiation, six surrounding rings, and the planet's old and newly found satellites were recorded. The encounter ended December 15, 1980. The spacecraft took more than 17,500 photographs of Saturn and its satellites.

  5. Analysis and Preliminary Results of The NPDGamma Experiment

    NASA Astrophysics Data System (ADS)

    Fry, Jason

    2014-03-01

    The NPDGamma Experiment measures the parity violating gamma asymmetry from polarized neutrons captured on protons at the Spallation Neutron Source at ORNL. The parity violating asymmetry Aγ between the neutron spin and the photon momentum is proportional to the ΔI = 1 long range weak meson coupling hπ1 between nucleons in the hadronic weak interaction. Liquid para-hydrogen production data has been taken since May 2012 and will continue in 2014 to measure Aγ to a precision of 1 ×10-8. Various aspects of the experiment, preliminary results, and plans to complete NPDGamma in 2014 will be discussed.

  6. Microwave remote sensing of snow experiment description and preliminary results

    NASA Technical Reports Server (NTRS)

    Ulaby, F. T. (Principal Investigator); Stiles, W. H.; Hanson, B. C.

    1977-01-01

    The active and passive microwave responses to snow were investigated at a site near Steamboat Springs, Colorado during the February and March winter months. The microwave equipment was mounted atop truck-mounted booms. Data were acquired at numerous frequencies, polarizations, and angles of incidence for a variety of snow conditions. The experiment description, the characteristics of the microwave and ground truth instruments, and the results of a preliminary analysis of a small portion of the total data volume acquired in Colorado are documented.

  7. Preliminary results from the second flight of CREAM

    NASA Astrophysics Data System (ADS)

    Marrocchesi, P. S.; Ahn, H. S.; Allison, P.; Bagliesi, M. G.; Barbier, L.; Beatty, J. J.; Bigongiari, G.; Brandt, T. J.; Childers, J. T.; Conklin, N. B.; Coutu, S.; DuVernois, M. A.; Ganel, O.; Han, J. H.; Jeon, J. A.; Kim, K. C.; Lee, M. H.; Lutz, L.; Maestro, P.; Malinine, A.; Minnick, S.; Mognet, S. I.; Nam, S. W.; Nutter, S.; Park, I. H.; Park, N. H.; Seo, E. S.; Sina, R.; Walpole, P.; Wu, J.; Yang, J.; Yoon, Y. S.; Zei, R.; Zinn, S. Y.

    Launched from McMurdo (Antarctica) in December 2005, the balloon experiment CREAM (cosmic ray energetics and mass) collected about 15 million triggers during its second flight of 28 days. Redundant charge identification, by two pixelated silicon arrays and a time resolved pulse shaping technique from a scintillator system, allowed a clear signature of the primary nuclei. The energy was measured with a tungsten/SciFi calorimeter preceded by a graphite target. Preliminary results from the analysis of the data of the second flight are presented.

  8. Preliminary results from the second flight of CREAM

    NASA Astrophysics Data System (ADS)

    Marrocchesi, P. S.; Cream Collaboration

    Launched from McMurdo Antarctica in December 2005 CREAM Cosmic Ray Energetics And Mass balloon experiment collected about 15 million triggers during its second flight of 28 days Redundant charge identification by two pixellated silicon arrays and a time resolved pulse shaping technique from a scintillator system allowed a clear signature of the primary nuclei The energy was measured with a tungsten SciFi calorimeter preceded by a graphite target Preliminary results on cosmic ray elemental composition from the data of the second flight will be presented

  9. V and V Efforts of Auroral Precipitation Models: Preliminary Results

    NASA Technical Reports Server (NTRS)

    Zheng, Yihua; Kuznetsova, Masha; Rastaetter, Lutz; Hesse, Michael

    2011-01-01

    Auroral precipitation models have been valuable both in terms of space weather applications and space science research. Yet very limited testing has been performed regarding model performance. A variety of auroral models are available, including empirical models that are parameterized by geomagnetic indices or upstream solar wind conditions, now casting models that are based on satellite observations, or those derived from physics-based, coupled global models. In this presentation, we will show our preliminary results regarding V&V efforts of some of the models.

  10. Preliminary Results from a New Analysis Method for EGRET Data

    NASA Technical Reports Server (NTRS)

    Thompson, D. J.; Bertsch, D. L.; Hunter, S. D.; Deines-Jones, P.; Dingus, B. L.; Kniffen, D. A.; Sreekumar, P.

    1999-01-01

    In order to extend the life of EGRET, the gas in the spark chamber was allowed to deteriorate more than was originally planned for the nominal two year Compton Observatory mission. Gamma ray events are lost because the pattern recognition analysis rules are not optimized for the poorer quality data. By changing the rules used by the data analysts, we can recover a significant fraction of the lost events, allowing improved statistics for detection and study of sources. Preliminary results from the Crab, Geminga, and BL Lacertae indicate the feasibility of this analysis.

  11. Preliminary Results from the Space Probe Pioneer V

    NASA Technical Reports Server (NTRS)

    Fan, C. Y.; Meyer, P.; Simpson, J. A.

    1960-01-01

    The space probe Pioneer V was launched March 11, 1960, into an orbit around the sun and inside the orbit of earth. The scientific apparatus included instruments identical with the University of Chicago apparatus used on Explorer VI [Fan, Meyer, and Simpson, 1960b], namely, energetic particle detectors which measure fluxes of protons with energies greater than 75 Mev, electrons with energies greater than 15 Mev, and the bremsstrahlung from electrons and y rays of lower energy. Simultaneously with the measurements in Pioneer V a series of four neutron monitor piles were recording the changes in cosmic radiation intensity at the earth. We report here on some preliminary results obtained from the Chicago experiments during the time within which Pioneer V traveled to a distance of approximately 8 x 10 km from earth. Beginning on March 20, solar activity rapidly increased with many solar flares, radio noise bursts, etc., over a period of 10 days. Most of our results relate to this period. The preliminary data are given in Figures 1 and 2.

  12. The 2011 Draconid outburst: UCM group preliminary results from Spain

    NASA Astrophysics Data System (ADS)

    Ocana, Francisco; Palos, Mario F.; Zamorano, Jaime; Sanchez de Miguel, Alejandro; Izquierdo, Jaime; Munoz-Ibanez, Barbara; Santamaria, Alejandro; Gallego, Jesus

    2013-01-01

    The Draconid outburst of October 8, 2011, originating from the 1900 and 1907 trails, took place as predicted (Vaubaillon et al., 2011, and references therein) at approximately 20h UT. The UCM group observed the event from the Observatorio de Sierra Nevada, a well-placed location at an elevation of 2900 m, with the radiant above 40 degrees altitude during the entire outburst. Continuous monitoring was also done from the Observatorio UCM at Madrid. Both stations used video techniques for flux measurements and DSLR imaging for orbit determination purposes. We obtained preliminary values of (221 +- 49) × 10-3 meteoroids per square kilometer per hour on October 8, 2012, at 20h06m UT, for meteoroids causing meteors brighter than magnitude +6.5 (meteoroid mass over 5 mg), assuming a population index r = 2.8. For meteoroids over 0.2 g, the maximum flux was (4.9 +- 1.1) × 10-3 km-2 h-1. These results are in good agreement with other preliminary results recently published. Despite the abundance of faint meteors, we recorded seven bright fireballs simultaneously from two or more stations, including a Draconid of magnitude -11 (Madiedo et al., 2012). They are currently being analyzed for trajectory and orbit determination.

  13. Preliminary Results Of A 600 Joules Small Plasma Focus Device

    NASA Astrophysics Data System (ADS)

    Lee, S. H.; Yap, S. L.; Wong, C. S.

    2009-07-01

    Preliminary results of a 600 J (3.7 μF, 18 kV) Mather type plasma focus device operated at low pressure will be presented. The discharge is formed between a solid anode with length of 6 cm and six symmetrically and coaxially arranged cathode rods of same lengths. The cathode base is profiled in a knife-edge design and a set of coaxial plasma gun are attached to it in order to initiate the breakdown and enhance the current sheath formation. The experiments have been performed in argon gas under a low pressure condition of several microbars. The discharge current and the voltage across the electrodes during the discharge are measured with high voltage probe and current coil. The current and voltage characteristics are used to determine the possible range of operating pressure that gives good focusing action. At a narrow pressure regime of 9.0±0.5 μbar, focusing action is observed with good reproducibility. Preliminary result of ion beam energy is presented. More work will be carried out to investigate the radiation output.

  14. Preliminary Results from the Smoke Aerosol Measurement Experiment - Reflight

    NASA Astrophysics Data System (ADS)

    Urban, D. L.; Ruff, G. A.; Mulholland, G. W.; Yuan, Z.; Cleary, T.; Yang, J.; Meyer, M. E.; Bryg, V. M.

    2012-01-01

    Preliminary results are presented from the Reflight of the Smoke Aerosol Measurement Experiment (SAME- R) which was conducted during Expedition 24 (July- September 2010). The reflight experiment built upon the results of the original flight during Expedition 15 by adding diagnostic measurements and expanding the test matrix. Five different materials representative of those found in spacecraft (Teflon, Kapton, cotton, silicone rubber and Pyrell) were heated to temperatures below the ignition point with conditions controlled to provide repeatable sample surface temperatures and air flow. Particle size determinations were made using aerosol instruments and by capturing particles for ground based examination in a Transmission Electron Microscope (TEM). Overall the majority of the average smoke particle sizes were found to be in the 200 to 400 nanometer range with the some of the quiescent cases producing substantially larger particles. When combined with particle morphology data from the TEM analysis, these results can be used to guide the design of future smoke detectors.

  15. Breast ultrasound tomography with two parallel transducer arrays: preliminary clinical results

    NASA Astrophysics Data System (ADS)

    Huang, Lianjie; Shin, Junseob; Chen, Ting; Lin, Youzuo; Intrator, Miranda; Hanson, Kenneth; Epstein, Katherine; Sandoval, Daniel; Williamson, Michael

    2015-03-01

    Ultrasound tomography has great potential to provide quantitative estimations of physical properties of breast tumors for accurate characterization of breast cancer. We design and manufacture a new synthetic-aperture breast ultrasound tomography system with two parallel transducer arrays. The distance of these two transducer arrays is adjustable for scanning breasts with different sizes. The ultrasound transducer arrays are translated vertically to scan the entire breast slice by slice and acquires ultrasound transmission and reflection data for whole-breast ultrasound imaging and tomographic reconstructions. We use the system to acquire patient data at the University of New Mexico Hospital for clinical studies. We present some preliminary imaging results of in vivo patient ultrasound data. Our preliminary clinical imaging results show promising of our breast ultrasound tomography system with two parallel transducer arrays for breast cancer imaging and characterization.

  16. Magnetic Field Observations near Mercury: Preliminary Results from Mariner 10.

    PubMed

    Ness, N F; Behannon, K W; Lepping, R P; Whang, Y C; Schatten, K H

    1974-07-12

    Results are presented from a preliminary analysis of data obtained near Mercury on 29 March 1974 by the NASA-GSFC magnetic field experiment on Mariner 10. Rather unexpectedly, a very well-developed, detached bow shock wave, which develops as the super-Alfvénic solar wind interacts with the planet, has been observed. In addition, a magnetosphere-like region, with maximum field strength of 98 gammas at closest approach (704 kilometers altitude), has been observed, contained within boundaries similar to the terrestrial magnetopause. The obstacle deflecting the solar wind flow is global in size, but the origin of the enhanced magnetic field has not yet been uniquely established. The field may be intrinsic to the planet and distorted by interaction with the solar wind. It may also be associated with a complex induction process whereby the planetary interior-atmosphere-ionosphere interacts with the solar wind flow to generate the observed field by a dynamo action. The complete body of data favors the preliminary conclusion that Mercury has an intrinsic magnetic field. If this is correct, it represents a major scientific discovery in planetary magnetism and will have considerable impact on studies of the origin of the solar system. PMID:17810508

  17. Preliminary test results with a Stirling Laboratory Research Engine

    NASA Technical Reports Server (NTRS)

    Hoehn, F. W.; Nguyen, B. D.; Schmit, D. D.

    1979-01-01

    The Jet Propulsion Laboratory has designed, assembled, and initiated testing of a Stirling Laboratory Research Engine (SLRE). This preprototype engine provides a research tool to support the development of a broad range of analytical modeling and experimental efforts. The SLRE is a horizontally opposed, two-piston, single-acting Stirling engine with a split crankshaft drive mechanism. The paper discusses the preliminary results obtained during engine motoring tests and compares these results with two different analytical prediction models. Comparisons are made between experiment, the classical Schmidt analysis, and the JPL Stirling Cycle Analysis Model (SCAM). SCAM is a computerized one-dimensional, cyclic, compressible flow model of the SLRE and consists of a compilation of individual component subroutines. The formulation and current state of development of the SCAM program is briefly described.

  18. Multi-GNSS Orbit and Clock Combination: Preliminary Results

    NASA Astrophysics Data System (ADS)

    Fritsche, Mathias

    2016-04-01

    In the framework of the Multi-GNSS Experiment (MGEX) a number of Analysis Centers (ACs) extended their software capabilities to process signals from the BeiDou, Galileo, and QZSS systems in addition to the well established systems GPS and GLONASS. Currently, the MGEX product portfolio covers precise satellite orbits and clocks, receiver clocks, signal biases, and Earth rotation parameters generated by the individual ACs. This presentation will provide an overview on the available AC-specific MGEX products. In addition, an introduction to a multi-GNSS orbit and clock combination procedure will be given. Finally, preliminary results from that multi-GNSS combination including a comparison with corresponding operational IGS products will be reported along with a discussion of the results.

  19. Implications of Scheduled ITC Reversion for RPS Compliance: Preliminary Results

    SciTech Connect

    Lowder, Travis; Miller, John; O'Shaughnessy, Eric; Heeter, Jenny

    2015-09-14

    This poster presents DRAFT initial results of a forthcoming NREL analysis. The analysis investigates the impacts of the scheduled investment tax credit (ITC) reversion from 30 percent to 10 percent for certain solar photovoltaic projects. Specifically, it considers whether the reversion will result in increased use of alternative compliance payments (ACPs) in lieu of solar renewable energy credits (SRECs) for renewable portfolio standard (RPS) compliance. The analysis models the effect of a 10 percent ITC on power purchase agreement (PPA) prices for non-residential systems in the eight states with solar carve-outs and solar ACPs. Our preliminary results suggest that states will likely install sufficient capacity to meet long-term targets through SRECs rather than ACPs following the ITC reversion. However, the analysis shows that the ITC reversion could affect project economics such that capacity shortfalls in certain states could temporarily increase the use of ACPs. NREL anticipates publishing a full report of this analysis in fall 2015. credits (SRECs) for renewable portfolio standard (RPS) compliance. The analysis models the effect of a 10 percent ITC on power purchase agreement (PPA) prices for non-residential systems in the eight states with solar carve-outs and solar ACPs. Our preliminary results suggest that states will likely install sufficient capacity to meet long-term targets through SRECs rather than ACPs following the ITC reversion. However, the analysis shows that the ITC reversion could affect project economics such that capacity shortfalls in certain states could temporarily increase the use of ACPs. NREL anticipates publishing a full report of this analysis in fall 2015.

  20. Preliminary Results from Galaxy Zoo: The Sloan by Eye

    NASA Astrophysics Data System (ADS)

    Lintott, Chris; Schawinski, K.; Land, K.; Slosar, A.; Szalay, A.; Bamford, S.; Nichol, R.; Thomas, D.; van den Berg, J.; Murray, P.; Raddick, J.; Andreescu, D.; Galaxy Zoo Team

    2007-12-01

    The relationship between the morphology of a galaxy and its formation and evolution is a fundamental question for modern astrophysics. However, classification by morphology is still most reliably performed by visual inspection of the data, and so in the era of large redshift surveys it is normal to estimate morphology via proxies for galaxy shape such as colour or the density profile (e.g. Bernardi et al. 2003). The use of such proxies must introduce a bias into the result (See Schawinski et al. 2007). In this presentation we present the first scientific results of the Galaxy Zoo project, which invited the public to inspect and classify galaxies drawn from the Sloan Digital Sky Survey (SDSS). (Our methodology is described in an accompanying outreach poster) More than 110,000 people have viewed more than 30 million images, leading to a catalogue of more than 300,000 galaxies with secure classifications. A comparison with smaller catalogues produced by professional astronomers (e.g. Fukugita et al. 2007) is used to demonstrate the accuracy of Galaxy Zoo classifications. One obvious advantage of our approach is the identification of galaxies that appear morphologically normal, but are otherwise unusual. As an example, we present preliminary results from a study of extremely blue early-type galaxies identified by the project. We also derive for the first time a low-redshift morphology-density relation which is based on visual morphologies, covering an unprecedented range of environments across the whole SDSS. In addition to galaxy morphology, classifiers were also asked to identify the sense of rotation of spiral galaxies; we present preliminary results providing a test of the cosmological principle, as well as constraints on the tidal torque theory of structure formation.

  1. Use of the KineSpring system in the treatment of medial knee osteoarthritis: preliminary results

    PubMed Central

    MADONNA, VINCENZO; CONDELLO, VINCENZO; PIOVAN, GIANLUCA; SCREPIS, DANIELE; ZORZI, CLAUDIO

    2015-01-01

    Purpose the purpose of this study was to analyze our preliminary results obtained with the KineSpring system in patients suffering from medial compartment knee osteoarthritis (OA). Methods between September 2012 and May 2014, 53 patients underwent treatment with the KineSpring system. Patient self-assessment was performed pre-operatively and at 3, 6 and 12 months postoperatively, and included the KOOS, Tegner activity score, Lysholm functional knee score, VAS knee pain score, and IKDC score. Device- and procedure-related adverse events were recorded. Results mean KOOS subscales, except for the Sport/Recreation subscale at six months, improved over time. Mean WOMAC Pain and Function domains, Lysholm score, IKDC score and VAS knee pain score improved over the follow-up period and were significantly improved at 3, 6 and 12 months postoperatively compared to baseline. Mean Tegner score improved slightly over time. In 5 of the 53 (9.4%) patients re-operation was necessary. In 3 patients the device was removed due to infection (one case) or persistent knee pain (two cases). Surgical arthrolysis was performed in two patients. Conclusions in our preliminary experience, the KineSpring system gave good short-term clinical results. Level of evidence Level IV, therapeutic case series. PMID:26889469

  2. Preliminary Results from the Mars Pathfinder ASI/MET Experiment

    NASA Technical Reports Server (NTRS)

    Haberle, R. M.; Schofield, J. T.; Crisp, D.; Barnes, J. R.; Magalhaes, J. A.; Murphy, J. R.; Seiff, A.; Wilson, G.; Larsen, S.; Young, Richard E. (Technical Monitor)

    1997-01-01

    Mars Pathfinder successfully landed in the Ares Vallis flood plain (19.3 N, 33.6 W) on July 4, 1997. The spacecraft carried a suite of instruments to record the structure of the atmosphere during the entry, descent, and landing as well as for monitoring meteorological phenomenon while on the surface. Collectively, these instruments are known as the ASI/MET experiment (Atmospheric Structure Investigation/Meteorology). In this paper we present preliminary results from the ASI/MET experiment. As of this writing, the spacecraft is healthy and continues to take daily meteorological measurements. We expect this will continue for almost one more earth year. Additional information is contained in the original extended abstract.

  3. Whole-body imaging at 7T: preliminary results.

    PubMed

    Vaughan, J Thomas; Snyder, Carl J; DelaBarre, Lance J; Bolan, Patrick J; Tian, Jinfeng; Bolinger, Lizann; Adriany, Gregor; Andersen, Peter; Strupp, John; Ugurbil, Kamil

    2009-01-01

    The objective of this study was to investigate the feasibility of whole-body imaging at 7T. To achieve this objective, new technology and methods were developed. Radio frequency (RF) field distribution and specific absorption rate (SAR) were first explored through numerical modeling. A body coil was then designed and built. Multichannel transmit and receive coils were also developed and implemented. With this new technology in hand, an imaging survey of the "landscape" of the human body at 7T was conducted. Cardiac imaging at 7T appeared to be possible. The potential for breast imaging and spectroscopy was demonstrated. Preliminary results of the first human body imaging at 7T suggest both promise and directions for further development. PMID:19097214

  4. Preliminary Experimental Results from a MARS Micro-CT System

    PubMed Central

    He, Peng; Yu, Hengyong; Thayer, Patrick; Jin, Xin; Xu, Qiong; Bennett, James; Tappenden, Rachael; Wei, Biao; Goldstein, Aaron; Renaud, Peter; Butler, Anthony; Butler, Phillip; Wang, Ge

    2013-01-01

    The Medipix All Resolution System (MARS) system is a commercial spectral/multi-energy micro-CT scanner designed and assembled by the MARS Bioimaging, Ltd. in New Zealand. This system utilizes the state-of-the-art Medipix photon-counting, energy-discriminating detector technology developed by a collaboration based at European Organization for Nuclear Research (CERN). In this paper, we report our preliminary experimental results using this system, including geometrical alignment, photon energy characterization, protocol optimization, and spectral image reconstruction. We produced our scan datasets with a multi-material phantom, and then applied ordered subset-simultaneous algebraic reconstruction technique (OS-SART) to reconstruct images in different energy ranges and principal component analysis (PCA) to evaluate spectral deviation between the energy ranges. PMID:22635175

  5. Preliminary XCOV26 results for EC14012-1446

    NASA Astrophysics Data System (ADS)

    Provencal, J. L.; Thompson, S.; Montgomery, M.; Kanaan, A.; Shipman, H. L.; Dalessio, J.; Childers, D.; Clemens, C.; Rosen, R.; Henrique, P.; Kim, A.; Strickland, W.; Chandler, D.; Walter, B.; Watson, T. K.; Castanheira, B.; Wood, M.; Vennes, S.; Kepler, S. O.; Reed, M.; Nitta, A.; Kleinman, S. J.; Brown, T.; Kim, S.-L.; Sullivan, D.; Chen, Wen-Ping; Yang, M.; Shih, Chia-You; Jiang, X. J.; Sergeev, A. V.; Maksim, A.; Janulis, R.; Vats, H. O.; Baliyan, K. S.; Zola, S.; Baran, A.; Winiarski, M.; Ogloza, W.; Paparo, M.; Bognar, Z.; Papics, P.; Kilkenny, D.; Sefako, R.; Buckley, D.; Loaring, N.; Kniazev, A.; Silvotti, R.; Galleti, S.; Handler, G.; Nagel, T.; Vauclair, G.; Dolez, N.; Fremy, J. R.; Perez, J.; Almenara, J. M.; Fraga, L.

    2009-06-01

    EC14012-1446 is a hydrogen atmosphere (DA) white dwarf pulsator. Its rich pulsation spectrum displays a range of excited modes with complex multiplet structure, in addition to numerous combination frequencies. In April 2008, EC14012-1446 was the primary target of XCOV26. We obtained over 300 hrs of nearly continuous high speed photometry with the goal of using the nonlinear pulse shapes to empirically determine the parameters of the convection zone. The Fourier transform (FT) of the light curve contains power between 1000 to 4000 μHz, with the dominant peak at 1234 μHz. We find 13 independent frequencies distributed in 8 modes, as well as a myriad of combination frequencies. In the following, we present preliminary results and lay the groundwork for future investigation leading to light curve fitting of EC14012-1446.

  6. Preliminary Results from the Second EUVE Right Angle Program Catalog

    NASA Astrophysics Data System (ADS)

    Christian, D. J.; Craig, N.; Cahill, W. D.; Roberts, B.; Malina, R. F.

    1997-12-01

    We present preliminary results of our search for new sources in the EUVE Right Angle Program (RAP) data. The EUVE all-sky survey telescopes (also known as ``scanners'') are mounted at right angles to the Deep Survey and spectrometer instruments, and obtain photometric data in four bands centered at ~ 100 Angstroms (Lexan/B), ~ 200 Angstroms (Al/Ti/C), ~ 400 Angstroms (Ti/Sb/Al), and ~ 550 Angstroms (Sn/SiO). This allows the Right Angle Program to accumulate data serendipitously during pointed spectroscopic observations. The long exposure times possible with RAP observations provide much greater sensitivity than the all-sky survey. One-half of the scanner data since January 1994 has been analyzed, yielding approximately 200 new source detections. We present light-curves and variability measurements for the brighter sources. We have detected stellar flares from several yet to be identified sources. Source identifications and distribution by type will be also be presented.

  7. MEMS-based microgratings: preliminary results of novel configurations

    NASA Astrophysics Data System (ADS)

    Castracane, James; Gutin, Mikhail A.

    1998-03-01

    The advent of micromachining has opened new doors for reducing the size and weight of conventional systems. A significant example is in the area of optics in which the size reduction can be exploited to produce ultra-miniature systems using MEMS device as the sensing or control elements. Using MEMS-based fabrication methods (the MUMPS runs), a series of optical diffraction gratings has been produced to examine limitations on the production methods and explore alternative applications. These devices consist of a variety of structures including single gratings, arrays of gratings and multi-periodic gratings. These devices are based on 3D architectures which can be adjusted in real time using electrostatic attraction from custom segmented electrode structures. The gratings were released and packaged for laboratory tests. Selected packaged devices were equipped with windows and integrated into a compact spectrograph to document spectral quality and performance. Preliminary results of mechanical, optical and electrical tests will be discussed.

  8. Preliminary results from LADEE's Neutral Mass Spectrometer (NMS)

    NASA Astrophysics Data System (ADS)

    Benna, Mehdi; Mahaffy, Paul; Hodges, Richard

    2014-05-01

    The Neutral Mass Spectrometer (NMS) of the Lunar Atmosphere and Dust Environment Explorer (LADEE) Mission is a high sensitivity quadrupole mass spectrometer designed to measure the composition and variability of the tenuous lunar atmosphere. The instrument has been observing the lunar exosphere since 10/17/2013, initially from a near circular 250 km altitude orbit and since 11/11/2013 from an elliptical orbit that reaches to 30-60 km altitude near the sunrise terminator. During its first four months in orbit, the NMS instrument successfully detected exospheric helium, argon and neon and mapped their spatial and temporal variability. Furthermore, the NMS instrument was able to establish new upper limits for many other exospheric species either sputtered or thermally evolved from the lunar surface. This talk will summarize these preliminary results from the NMS measurements.

  9. Preliminary Test Results for the MICE Spectrometer Superconducting Solenoids

    SciTech Connect

    Virostek, Steve P.; Green, Michael A; Li, Derun; Zisman, Michael S.; Wang, S.T.; Wahrer, R.; Taylor, Clyde; Lu, X.; Chen, J. Y.; Wang, Mimi; Juang, Tiki

    2008-08-02

    This report describes the MICE spectrometer solenoids as built. Each magnet consists of five superconducting coils. Two coils are used to tune the beam going from or to the MICE spectrometer from the rest of the MICE cooling channel. Three spectrometer coils (two end coils and a long center coil) are used to create a uniform 4 T field (to {+-}0.3 percent) over a length of 1.0 m within a diameter of 0.3 m. The three-coil spectrometer set is connected in series. The two end coils use small power supplies to tune the uniform field region where the scintillating fiber tracker is located. This paper will present the results of the preliminary testing of the first spectrometer solenoid.

  10. Preliminary results of non-contact THz imaging of cornea

    NASA Astrophysics Data System (ADS)

    Sung, Shijun; Garritano, James; Bajwa, Neha; Deng, Sophie; Hubschman, Jean-Pierre; Grundfest, Warren S.; Taylor, Zachary D.

    2015-03-01

    This paper presents a novel THz optical design that allows the acquisition of THz reflectivity maps of in vivo cornea without the need for a field flattening window and preliminary imaging results of in vivo rabbit cornea. The system's intended use is to sense small changes in corneal tissue water content (CTWC) that can be precursors for a host of diseases and pathologies. Unique beam optics allows the scanning of a curved surface at normal incidence while keeping the source detector and target stationary. Basic system design principles are discussed and image sets of spherical calibration targets and corneal phantom models are presented. The presented design will enable, for the first time, non-contact THz imaging of animal and human cornea.

  11. Preliminary results of non-contact THz imaging of cornea

    PubMed Central

    Sung, Shijun; Garritano, James; Bajwa, Neha; Deng, Sophie; Hubschman, Jean-Pierre; Grundfest, Warren S.

    2015-01-01

    This paper presents a novel THz optical design that allows the acquisition of THz reflectivity maps of in vivo cornea without the need for a field flattening window and preliminary imaging results of in vivo rabbit cornea. The system’s intended use is to sense small changes in corneal tissue water content (CTWC) that can be precursors for a host of diseases and pathologies. Unique beam optics allows the scanning of a curved surface at normal incidence while keeping the source detector and target stationary. Basic system design principles are discussed and image sets of spherical calibration targets and corneal phantom models are presented. The presented design will enable, for the first time, non-contact THz imaging of animal and human cornea. PMID:26321784

  12. Esa's biopan 1 — "Vitamin" experiment preliminary results

    NASA Astrophysics Data System (ADS)

    Moatti, J.-P.; Dousset, N.; Moattit, N.; Degre, M.; Eche, B.; Gasset, G.; Tixador, R.

    The purpose of "Vitamin" experiment is to study the efficiency of protective substances on three biological acellular systems aqueous solutions exposed to cosmic radiation in space. The first system "LDL"is a low density lipoprotein. The second is "E2-TeBG complexe" in which estradiol (E2) is bound to its plasmatic carrier protein, testosterone-estradiol binding globulin (TeBG). The third is "pBR 322", a plasmid. "Vitamin" experiment was accomodated in the Biopan which had been mounted on the outer surface of a Foton retrievable satellite. The experiment was exposed to space environment during 15 days. A stable temperature of about 20 °C was maintained throughout the flight. "Vitamin" experiment preliminary results are presented and discussed.

  13. RF tomography of metallic objects in free space: preliminary results

    NASA Astrophysics Data System (ADS)

    Li, Jia; Ewing, Robert L.; Berdanier, Charles; Baker, Christopher

    2015-05-01

    RF tomography has great potential in defense and homeland security applications. A distributed sensing research facility is under development at Air Force Research Lab. To develop a RF tomographic imaging system for the facility, preliminary experiments have been performed in an indoor range with 12 radar sensors distributed on a circle of 3m radius. Ultra-wideband pulses are used to illuminate single and multiple metallic targets. The echoes received by distributed sensors were processed and combined for tomography reconstruction. Traditional matched filter algorithm and truncated singular value decomposition (SVD) algorithm are compared in terms of their complexity, accuracy, and suitability for distributed processing. A new algorithm is proposed for shape reconstruction, which jointly estimates the object boundary and scatter points on the waveform's propagation path. The results show that the new algorithm allows accurate reconstruction of object shape, which is not available through the matched filter and truncated SVD algorithms.

  14. Preliminary Results From the First Flight of ATIC

    NASA Technical Reports Server (NTRS)

    Seo, E. S.; Adams, James H., Jr.; Ahn, H.; Ampe, J.; Bashindzhagyan, G.; Case, G.; Whitaker, Ann F. (Technical Monitor)

    2001-01-01

    The Advanced Thin Ionization Calorimeter (ATIC) instrument is designed to measure the composition C and energy spectra of Z = 1 to 28 cosmic rays over the energy range approximately 10 GeV - 100 TeV. The instrument was calibrated in September 1999 at CERN using accelerated electron, proton and pion beams. ATIC was launched as a long duration balloon test flight on 12/28/00 local time from McMurdo, Antarctica. After flying successfully for about 16 days the payload was recovered in excellent condition. Absolute calibration of the detector response was made using cosmic-ray muons. The data analysis algorithm which was developed with Monte Carlo simulations and validated with the CERN beam test will be used for the flight data analysis. Preliminary results of the protons and C helium spectra will be reported in this paper.

  15. Preliminary Results From The First Flight of ATIC

    NASA Technical Reports Server (NTRS)

    Seo, E. S.; Whitaker, Ann F. (Technical Monitor)

    2001-01-01

    The Advanced Thin Ionization Calorimeter (ATIC) instrument is designed to measure the composition and energy spectra of Z = 1 to 28 cosmic rays over the energy range approximately 10 GeV - 100 TeV. The instrument was calibrated in September 1999 at CERN using accelerated electron, proton and pion beams. ATIC was launched as a long duration balloon test flight on 12/28/00 local time from McMurdo, Antarctica. After flying successfully for about 16 days the payload was recovered in excellent condition. Absolute calibration of the detector response was made using cosmic-ray muons. The data analysis algorithm which was developed with Monte Carlo simulations and validated with the CERN beam test will be used for the flight data analysis. Preliminary results of the proton and helium spectra will be reported in this paper.

  16. Preliminary winter results in the thermal envelope concept test room

    SciTech Connect

    Chen, B.; Hollingsworth, E.; Holmes, W.; Maloney, J.; Pedersen, K.; Sash, R.; Thorp, J.; Wang, M.

    1980-01-01

    Within the passive solar energy field few passive techniques have caught the imagination and the attention of the public as has the continuous thermal envelope (CTE) concept. The Tom Smith residence located in Lake Tahoe has been the center of attention of a number of popular magazines. Yet despite the widespread public interest not a great deal is known concerning the actual technical performance of continuous thermal envelope systems, that is until now. Just such a CTE test room was erected during the spring and summer of 1979 at the Passive Solar Energy Test Facility located on the Omaha campus of the University of Nebraska. The CTE system has been undergoing testing since November of 1979. The CTE test room is heavily instrumented with temperature sensors and air flow meters which are located throughout, around, and under the structure. There are nearly one hundred such sensors. The results of these preliminary experiments are presented.

  17. Preliminary science results from the Shuttle Imaging Radar-B

    NASA Technical Reports Server (NTRS)

    Ruzek, M.

    1985-01-01

    Preliminary results of analyzing digital radar imagery data obtained by the SIR-B aboard the Space Shuttle Challenger STS 41-G are presented. The data cover 5 million square kilometers of the earth surface between 57 deg north and south latitudes. Radar imagery of the same target at different incidence angles was used to classify surfaces by their backscatter response as a function of incidence angle. The SIR-B proved to be useful for collecting multiple incidence angle data sets over a broad range of targets, providing information in the areas of geology, archeology, forestry, agriculture, oceanography, geography, and hydrology. The analysis is also used to optimize radar parameters such as look angle for future missions.

  18. Charge breeder for the SPIRAL1 upgrade: Preliminary results

    NASA Astrophysics Data System (ADS)

    Maunoury, L.; Delahaye, P.; Dubois, M.; Angot, J.; Sole, P.; Bajeat, O.; Barton, C.; Frigot, R.; Jeanne, A.; Jardin, P.; Kamalou, O.; Lecomte, P.; Osmond, B.; Peschard, G.; Lamy, T.; Savalle, A.

    2016-02-01

    In the framework of the SPIRAL1 upgrade under progress at the GANIL lab, the charge breeder based on a LPSC Phoenix ECRIS, first tested at ISOLDE has been modified to benefit of the last enhancements of this device from the 1+/n+ community. The modifications mainly concern the 1 + optics, vacuum techniques, and the RF—buffer gas injection into the charge breeder. Prior to its installation in the midst of the low energy beam line of the SPIRAL1 facility, it has been decided to qualify its performances and several operation modes at the test bench of LPSC lab. This contribution shall present preliminary results of experiments conducted at LPSC concerning the 1 + to n+ conversion efficiencies for noble gases as well as for alkali elements and the corresponding transformation times.

  19. The endovenous ASVAL method: principles and preliminary results

    PubMed Central

    Atasoy, Mehmet Mahir; Oğuzkurt, Levent

    2016-01-01

    PURPOSE We aimed to investigate the feasibility and safety of the endovenous ambulatory selective varicose vein ablation under local anesthesia (eASVAL) method in a selected group of patients with varicose disease and present the short-term results of one-year ultrasonographic follow-up. METHODS Three hundred and ninety-five consecutive patients with varicose veins who had been treated with endovenous laser ablation (EVLA) were retrospectively reviewed over a period of two years. From this group, 41 patients who were treated using the eASVAL technique and had the great saphenous vein (GSV) preserved were included in the study. These patients had only limited segmental GSV reflux accompanied by a competent terminal valve. The eASVAL technique can be defined as EVLA of the proximal straight segments of the major tributaries connecting the symptomatic varicose veins with the GSV, followed by ultrasound-guided foam sclerotherapy of the superficial varicose veins themselves. The patients were assessed before and after the treatment by duplex scan findings and clinical assessment scores. RESULTS The GSVs were successfully preserved in all 41 cases, and all patients showed significant clinical improvement using the eASVAL approach (P < 0.001). Segmental reflux was no longer present in 75.3% of patients. The mean diameters of the GSVs were significantly reduced at one-year follow-up (8.5 mm vs. 7.5 mm, P < 0.001). CONCLUSION eASVAL is a feasible and safe procedure in selected patients, with promising results at one-year ultrasonographic follow-up. However, prospective studies are required, comparing this approach with the standard techniques. PMID:26573978

  20. Polyurethane-Covered Self-expandable Nitinol Stent for Malignant Biliary Obstruction: Preliminary Results

    SciTech Connect

    Han, Young-Min; Hwang, Seung-Bae; Lee, Soo-Teik; Lee, Jeong-Min; Chung, Gyung-Ho

    2002-10-15

    Purpose: To evaluate the immediate and long-term results in ten patients with malignant biliary obstruction using a polyurethane-covered, self-expandable nitinol stent.Methods: A nitinol stent, fully covered with high-elasticity polyurethane, with an unconstrained diameter of 10 mm and a total length of 60-80 mm, was placed transhepatically under fluoroscopic guidance in ten patients. The length of the biliary obstruction varied between 30-50 mm. The follow-up examination included a clinical assessment, serum bilirubin measurement, and ultrasound examinations at one-month intervals in all patients. Results: Initial stent deployment was successful in eight patients. Two patients experienced proximal migration,which was solved by insertion of two, uncovered Wallstents. One patient had the stent removed after two weeks because of severe nausea and vomiting. One patient had delayed migration of the covered stent after 40 weeks. The follow-up duration was 3-40 weeks (Mean: 16.9 weeks). Seven patients died(3-26 weeks) and three patients survived (24-40 weeks). The bilirubin measurements in all patients had significantly decreased one week after stent insertion. The levels of amylase and lipase had did not increase after stent insertion. Conclusions: Apolyurethane-covered, self-expandable nitinol stent can be used effectively and safely in the treatment of malignant biliary obstruction. The preliminary results are favorable, but there is a need for further large studies to determine both long-term survival and patency.

  1. Benchmarking the Integration of WAVEWATCH III Results into HAZUS-MH: Preliminary Results

    NASA Technical Reports Server (NTRS)

    Berglund, Judith; Holland, Donald; McKellip, Rodney; Sciaudone, Jeff; Vickery, Peter; Wang, Zhanxian; Ying, Ken

    2005-01-01

    The report summarizes the results from the preliminary benchmarking activities associated with the use of WAVEWATCH III (WW3) results in the HAZUS-MH MR1 flood module. Project partner Applied Research Associates (ARA) is integrating the WW3 model into HAZUS. The current version of HAZUS-MH predicts loss estimates from hurricane-related coastal flooding by using values of surge only. Using WW3, wave setup can be included with surge. Loss estimates resulting from the use of surge-only and surge-plus-wave-setup were compared. This benchmarking study is preliminary because the HAZUS-MH MR1 flood module was under development at the time of the study. In addition, WW3 is not scheduled to be fully integrated with HAZUS-MH and available for public release until 2008.

  2. Preliminary on-orbit results of trigger system for DAMPE

    NASA Astrophysics Data System (ADS)

    Zhang, Yongqiang; Chang, Jin; Guo, Jian hua; Dong, TieKuang; Liu, Yang

    2016-07-01

    The Dark Matter Particle Explorer (DAMPE), Chinese first high energy cosmic ray explorer in space, has been successfully launched at Jiuquan Satellite Launch Center, with the mission of searching dark matter particle. Large energy range for electron/gamma, good energy resolution, and excellent PID ability, make DAMPE to be the most promising detector so far to find the signal of dark matter. DAMPE consists of four sub-detectors: Plastic Scintillation detector, Silicon-Tungsten tracker, BGO calorimeter and Neutron detector. The hit signals generated by the BGO calorimeter and the trigger board (in DAQ) constitute the trigger system of DAMPE, which will generate trigger signals for the four sub-detectors to start data acquisition. The trigger system reduces the trigger rates on orbit from about 1kHz to 70~100Hz, that releases the stress of DAQ transmitting data to ground. In this paper, we will introduce the trigger system of DAMPE, and present some preliminary on-orbit results e.g. trigger efficiency, together with the beam test results at CERN and the simulation results as comparison.

  3. Avian demography in mosaic landscapes: modeling paradigm and preliminary results

    SciTech Connect

    Urban, D.L.; Shugart, H.H. Jr.

    1984-01-01

    We pursued a mechanistic explanation for the local extinction of some avian species from small and/or isolated patches in a habitat mosaic. A model was developed to simulate demographic processes of natality, dispersal, and mortality as these might occur in a mosaic of discrete habitat patches. These processes were adjusted to reflect life-history attributes that seem to confer sensitivity to habitat fragmentation. We used the model to explore the effects of restricted vagility and reduced natality resulting from biotic interactions for a hypothetical bird species. Restricted vagility resulted in local extinctions in small, isolated patches, but this effect was buffered by an available pool of surplus nonbreeders. Lower natality reduced this suplus so as to increase the frequency of local extinction, and allowed restricted vagility to play a more important role in affecting species distribution. Moderate levels of restricted vagility and reduced natality were synergistic in effect. In general, small patches in isolation tended to lose their populations permanently, large patches rarely suffered extinctions, but small and intermediate patches adjacent to other patches suffered extinctions and were recolonized repeatedly. The basic modeling approach can be expanded to include greater mechanistic detail, but implementation has been limited by a lack of appropriate data. Our preliminary results suggest which data are necessary to pursue a mechanistic, patch-scale understanding of species demography at the landscape scale. 17 references, 5 figures, 3 tables.

  4. Analytic study of the Tadoma method: background and preliminary results.

    PubMed

    Norton, S J; Schultz, M C; Reed, C M; Braida, L D; Durlach, N I; Rabinowitz, W M; Chomsky, C

    1977-09-01

    Certain deaf-blind persons have been taught, through the Tadoma method of speechreading, to use vibrotactile cues from the face and neck to understand speech. This paper reports the results of preliminary tests of the speechreading ability of one adult Tadoma user. The tests were of four major types: (1) discrimination of speech stimuli; (2) recognition of words in isolation and in sentences; (3) interpretation of prosodic and syntactic features in sentences; and (4) comprehension of written (Braille) and oral speech. Words in highly contextual environments were much better perceived than were words in low-context environments. Many of the word errors involved phonemic substitutions which shared articulatory features with the target phonemes, with a higher error rate for vowels than consonants. Relative to performance on word-recognition tests, performance on some of the discrimination tests was worse than expected. Perception of sentences appeared to be mildly sensitive to rate of talking and to speaker differences. Results of the tests on perception of prosodic and syntactic features, while inconclusive, indicate that many of the features tested were not used in interpreting sentences. On an English comprehension test, a higher score was obtained for items administered in Braille than through oral presentation. PMID:904318

  5. The Myres Hill remote sensing intercomparison study: preliminary results

    NASA Astrophysics Data System (ADS)

    Clive, P. J. M.; Chindurza, I.; Ravey, I.; Bass, J.; Boyle, R. J.; Jones, P.; Lang, S. J.; Bradley, S.; Hay, L.; Oldroyd, A.; Stickland, M.

    2008-05-01

    Two remote sensing techniques (SODAR and LIDAR) have been developed for measuring wind speed and turbulence from ground level up to altitudes of 300 m or higher. Although originally developed in the defence sector, these techniques are now generating considerable interest in the renewable energy and meteorological sectors. Despite the benefits of these instruments they are not yet generally accepted for due diligence measurements by wind energy developers and financial institutions. There is a requirement for a series of independent assessments of these new metrology techniques, comparing their measurements with the approved cup-type anemometer readings. This is being addressed at TUV NEL's Myres Hill wind turbine test site in a measurement programme supported by the DIUS National Measurement Systems Measurement for Innovators scheme and a consortium of 21 industrial collaborators. Data from SODAR and LIDAR systems are being compared with results from cup-type anemometers mounted at different heights on an 80m meteorological mast. An ultrasonic sensor is also mounted on the mast. The objective of the test programme is to assess the effectiveness of SODAR and LIDAR wind speed measurement techniques under different operating regimes and atmospheric conditions. Results from the measurements will provide definitive data on the performance of the remote wind speed sensing techniques under test on complex terrain typical of many wind farm sites. Preliminary measurements based on data acquired during the initial measurement campaign are presented.

  6. Sand transport on Mars: Preliminary results from models

    NASA Technical Reports Server (NTRS)

    Greeley, R.; Anderson, F. S.; Blumberg, D.; Lo, E.; Xu, P.; Pollack, J.

    1993-01-01

    Most studies of active aeolian processes on Mars have focused on dust, i.e., particles approximately 1 micron in diameter that are transported in suspension by wind. The presence of sand dunes on Mars indicates that larger grains (approximately greater than 60 microns, transported primarily in saltation) are also present. Although indirect evidence suggests that some dunes may be active, definitive evidence is lacking. Nonetheless, numerous studies demonstrate that sand is substantially easier to transport by wind than dust, and it is reasonable to infer that sand transportation in saltation occurs under present Martian conditions. In order to assess potential source regions, transportation pathways, and sites of deposition for sand on Mars, an iterative sand transport algorithm was developed that is based on the Mars General Circulation Model of Pollack et al. The results of the dust transport model are then compared with observed surface features, such as dune field locations observed on images, and surficial deposits as inferred from Viking IRTM observations. Preliminary results suggest that the north polar dune fields in the vicinity of 270 degrees W, 70 degrees N originated from weathered polar layered plains centered at 280 degrees W, 85 degrees N, and that Thaumasia Fossae, southern Hellas Planitia, and the area west of Hellespontus Montes are sand depositional sites. Examples of transportation 'corridors' include a westward pathway in the latitudinal band 35 degrees N to 45 degrees N, and a pathway southward from Solis Planum to Thaumasia Fossae, among others.

  7. Preliminary results of centroiding experiment for the STEP mission

    NASA Astrophysics Data System (ADS)

    Li, Haitao; Li, Baoquan; Cao, Yang; Chen, Ding; Li, Ligang

    2015-08-01

    Search for Terrestrial Exo-Planet (STEP)[1] was originally proposed in 2013 by the National Space Science Center, Chinese Academy of Sciences, which is currently being under background engineering study phase in China. The STEP mission is a space astrometry telescope working at visible light wavelengths. The STEP aims at the nearby terrestrial planets detection through micro-arcsecond-level astrometry. Determination of the separation between star images on a detector with high precision is very important for astrometric exoplanets detection through the observation of star wobbles due to planets. The requirement of centroiding accuracy for STEP is 1e-5 pixel. A centroiding experiment have been carried out on a metrology testbed in open laboratory. In this paper, we present the preliminary results of determining the separations between star images. Without calibration of pixel positions and intra-pixel response, we have demonstrated that the standard deviation of differential centroiding is below 7.4e-3 pixel by the algorithm of linear corrected photon weighted means(LCPWM)[2,3]. For comparison, the photon weighted means(PWM) and Gauss fitting are also used in the data reduction. These results pave the way for the geometrical calibration and the intra-pixel quantum efficiency(QE) calibration of detector array equipment for micro-pixel accuracy centroiding.

  8. Tissue characterization using magnetic resonance elastography: preliminary results*

    NASA Astrophysics Data System (ADS)

    Kruse, S. A.; Smith, J. A.; Lawrence, A. J.; Dresner, M. A.; Manduca, A.; Greenleaf, J. F.; Ehman, R. L.; Kruse, S. A.; Smith, J. A.; Lawrence, A. J.; Dresner, M. A.; Manduca, A.; Greenleaf, J. F.

    2000-06-01

    The well-documented effectiveness of palpation as a diagnostic technique for detecting cancer and other diseases has provided motivation for developing imaging techniques for non-invasively evaluating the mechanical properties of tissue. A recently described approach for elasticity imaging, using propagating acoustic shear waves and phase-contrast MRI, has been called magnetic resonance elastography (MRE). The purpose of this work was to conduct preliminary studies to define methods for using MRE as a tool for addressing the paucity of quantitative tissue mechanical property data in the literature. Fresh animal liver and kidney tissue specimens were evaluated with MRE at multiple shear wave frequencies. The influence of specimen temperature and orientation on measurements of stiffness was studied in skeletal muscle. The results demonstrated that all of the materials tested (liver, kidney, muscle and tissue-simulating gel) exhibit systematic dependence of shear stiffness on shear rate. These data are consistent with a viscoelastic model of tissue mechanical properties, allowing calculation of two independent tissue properties from multiple-frequency MRE data: shear modulus and shear viscosity. The shear stiffness of tissue can be substantially affected by specimen temperature. The results also demonstrated evidence of shear anisotropy in skeletal muscle but not liver tissue. The measured shear stiffness in skeletal muscle was found to depend on both the direction of propagation and polarization of the shear waves.

  9. Spitzer IRS Spectra of Basaltic Asteroids: Preliminary Results

    NASA Technical Reports Server (NTRS)

    Lim, Lucy F.; Emery, Joshua P.; Moskovitz, Nick; Stewart, Heather; Marchis, Frank

    2008-01-01

    We present preliminary results of a Spitzer program to observe the 5.2--38 micron spectra of small basaltic asteroids using the Spitzer IRS (Infrared Spectrograph). Our targets include members of the dynamical family of the unique large differentiated asteroid 4 Vesta ("Vestoids"), four outer-main-belt basaltic asteroids whose orbits exclude them from originating on 4 Vesta, and the basaltic near-Earth asteroid (NEA) 4055 Magellan. We will compare the compositions and thermophysical properties of the non-Vestoid objects with those of the dynamical vestoids to provide insight on the extent of metal-silicate differentiation on planetsimals during the epoch of planet formation in the early Solar System. As of this writing, spectra of asteroids 10537 (1991 RY16) and 2763 Jeans have been returned. Analysis of these data are ongolng. Observations of 956 Elisa, 2653 Principia, 4215 Kamo, 7472 Kumakiri, and 1459 Magnya have been scheduled and are expected to be available by the time of the DPS meeting. NIR spectra and lightcurves o f the target asteroids are also being observed in support of this program.

  10. Ultrasonic Evaluation of Deeply Located Trabecular Bones - Preliminary Results

    NASA Astrophysics Data System (ADS)

    Cieślik, Lucyna; Litniewski, Jerzy

    The analysis of ultrasonic signals scattered by soft tissues have been successfully applied for their characterization. Similarly, the trabecular bone backscattered signal contains information about the properties of the bone structure. Therefore scattering-based ultrasonic technique potentially enables the assessment of microstructure characteristics of a bone. The femoral neck fracture often occurs in the course of osteoporosis and can lead to severe complications. Therefore assessment of femoral bone microstructure and condition is important and essential for the diagnosis and treatment monitoring. As far most of the trabecular bone investigations have been performed in vitro. The only in vivo measurements were carried out in transmission and mostly concerned estimation of the attenuation in heel bone. We have built the ultrasonic scanner that could be useful in acquiring the RF (Radio Frequency) echoes backscattered by the trabecular bone in vivo. Moreover, the bone scanner provides data not only from heel bone but from deeply located bones as well (e.g. femoral bone). It can be also used for easily accessible bones like heel bone or breastbone. In this case a gel-pad is applied to assure focusing of ultrasound in trabecular bone (approximately 10 mm beneath the cortical bone). This study presents preliminary results of the attenuating properties evaluation of trabecular bone from the ultrasonic echoes backscattered by heel bone and femoral neck.

  11. Enhancement of perfluoropolyether boundary lubrication performance: I. Preliminary results

    NASA Technical Reports Server (NTRS)

    Jones, W. R., Jr.; Ajayi, O. O.; Goodell, A. J.; Wedeven, L. D.; Devine, E.; Premore, R. E.

    1995-01-01

    A ball bearing simulator operating under starved conditions was used to evaluate the boundary lubrication performance of a perfluoropolyether (PFPE) Krytox 143 AB. Several approaches to enhance boundary lubrication were studied. These included: (1) soluble boundary additives, (2) bearing surface modifications, (3) 'run-in' surface films, and (4) ceramic bearing components. In addition, results were compared with two non-perfluorinated liquid lubricant formulations. Based on these preliminary tests, the following tentative conclusions can be made: (1) substantial improvements in boundary lubrication performance were observed with a beta-diketone boundary additive and a tricresyl phosphate (TCP) liquid surface pretreatment; (2) the use of rough Si3N4 balls (Ra = 40 micro-in) also provided substantial improvement but with concomitant abrasive wear; (3) marginal improvements were seen with two boundary additives (a phosphine and a phosphatriazine) and a neat (100%) fluid (a carboxylic acid terminated PFPE); and surface pretreatments with a synthetic hydrocarbon, a PTFE coating, and TiC coated 440C and smooth Si3N4 balls (R(sub a) less than 1 micro-in); and (4) two non-PFPE lubricant formulations (a PAO and a synthetic hydrocarbon) yielded substantial improvements.

  12. Auroral Spatial Structures Probe Sub-Orbital Mission Preliminary Results

    NASA Astrophysics Data System (ADS)

    Pratt, J.; Swenson, C.; Martineau, R. J.; Fish, C. S.; Conde, M.; Hampton, D.; Crowley, G.

    2015-12-01

    The NASA Auroral Spatial Structures Probe, 49.002, was launched January 28, 2015 from the Poker Flat Research Range into active aurora over the northern coast of Alaska. The primary objective of this mission was to determine the contribution of small spatial and temporal scale fluctuations of the electric fields to the larger-scale energy deposition processes associated with the aurora. The Auroral Spatial Structures Probe Sub-Orbital Mission consisted of a formation of 7 spacecraft (a main payload with 6 deployable sub-payloads) designed for multiple temporally spaced co-located measurements of electric and magnetic fields in the earth's ionosphere. The mission was able to make observations at a short time scale and small spatial scale convergence that is unobservable by either satellite or ground-based observations. The payloads included magnetometers, electric field double probes, and Langmuir probes as well as a sweeping impedance probe on the main payload. We present here preliminary results from the measurements taken that hint at the underlying spatial structure of the currents and energy deposition in the aurora. The Poynting flux derived from the observations is shown and implications are discussed in terms of the contribution of small spatial scale, rapid temporal scale fluctuations in the currents that deposit energy in the auroral region. Funding provided by NASA Grants NNX11AE23G and NNX13AN20A.

  13. SWCX Emission from the Helium Focusing Cone - Preliminary Results

    NASA Technical Reports Server (NTRS)

    Snowden, S. L.; Kuntz, K. D.; Collier, M. R.

    2008-01-01

    Preliminary results from an XMM-Newton campaign to study solar wind charge exchange (SWCX) emission from the heliospheric focusing cone of interstellar helium are presented. The detections of enhanced O VII and O VIII emission from the cone are at the 2(sigma) and 4(sigma) levels. The solar wind charge exchange (SWCX) emission in the heliosphere not associated with distinct objects (e.g., comets and planets including exospheric material in and near Earth s magnetosheath) is proportional to the flux of the solar wind and the space density of neutral material. The neutral material originates in the interstellar medium (ISM) and passes through the solar system due to the relative motion of the Sun and the ISM. The flow of the neutral material through the solar system is strongly perturbed by the Sun both by gravity and by radiation pressure. Because of the relative radiative scattering cross sections and the effect of solar gravitation the density of interstellar hydrogen near the Sun is reduced while interstellar helium is gravitationally focused. This creates a helium focusing cone downstream of the Sun [e.g., 1, and references therein].

  14. Large co-axial pulse tube preliminary results

    NASA Astrophysics Data System (ADS)

    Emery, N.; Caughley, A.; Meier, J.; Nation, M.; Tanchon, J.; Trollier, T.; Ravex, A.

    2014-01-01

    We report that Callaghan Innovation, formally known as Industrial Research Ltd (IRL), has designed and built its largest of three high frequency single-stage co-axial pulse tubes, closely coupled to a metal diaphragm pressure wave generator (PWG). The previous pulse tube achieved 110 W of cooling power @ 77 K, with an electrical input power of 3.1 kW from a 90 cc swept volume PWG. The pulse tubes have all been tuned to operate at 50 Hz, with a mean helium working pressure of 2.5 MPa. Sage pulse tube simulation software was used to model the latest pulse tube and predicted 280 W of cooling power @ 77 K. The nominal 250 W cryocooler was designed to be an intermediate step to up-scale pulse tube technology for our 1000 cc swept-volume PWG, to provide liquefaction of gases and cooling for HTS applications. Details of the modeling, design, development and preliminary experimental results are discussed.

  15. Pg shingles: preliminary results from the onshore GLIMPCE refraction experiment

    NASA Astrophysics Data System (ADS)

    Mereu, R. F.; Epili, D.; Green, A. G.

    1990-02-01

    In 1986, a series of near vertical Seismic reflection lines and coincident Seismic refraction lines were recorded across the Great Lakes in the GLIMPCE experiment. From a refraction point of view this experiment was unique as this was the first time in North America that long range refraction lines up to 350 km were recorded with a trace spacing of less than 100 metres. The source of energy was a large air gun. Some preliminary results of the nature of the onshore recordings made by the University of Western Ontario are presented in this paper. Observations of many of the in-line profiles show that the character of the Pg crustal phase is not simple but has a "shingle-like" pattern which may be caused by wide-angle reflection effects from numerous long and short reflectors within the crust. Theoretical studies indicate that the amplitudes of the wide-angle reflected signals from thin high-velocity layers are in general much larger than those from thin low-velocity layers. Supercritical reflected waves are not possible from the top of a low-velocity layer. The closely spaced traces show in minute detail the manner in which one travel-time branch fades and the next one arrives. The results seem to indicate that the Pg phase in our data set has little direct wave component but, instead, is made up of a whole series of "shingled or fish-scaled" wide-angle reflection components, each with successively larger apparent velocities. These results are in agreement with the findings of the near-vertical reflection component of the experiment.

  16. Preliminary Results From the COMET CGPS Network in Greece

    NASA Astrophysics Data System (ADS)

    Floyd, M. A.; Nocquet, J.; Billiris, H.; Paradissis, D.; England, P.; Parsons, B.

    2004-12-01

    The Hellenic subduction zone accommodates the convergence between the oceanic lithosphere of the African plate and the extending continental lithosphere of the Aegean. Former studies (e.g. Jackson & McKenzie, 1988) concluded that earthquakes can only account for 10% of the relative motion, suggesting that the subduction is in a stable sliding state. In contrast, some authors (e.g. Pirazzoli et al., 1982), using the Holocene geological record, suggested that large earthquakes (M>8) may have occurred in historical times, indicating that the zone may be locked. In order to discriminate between these two views, a network of permanent GPS stations is being developed throughout the south-west Aegean region to monitor the strain accumulation and release along the interface and over the surrounding region, and potentially detect aseismic slip events as seen in others subduction zone (e.g. Dragert et al., 2001). We analyse the CGPS network together with a subset of IGS and EUREF sites in Europe on a routine basis to derive the daily solutions and time series. We present the analysis of the time series and results for sites having about 18 months of data. Preliminary estimates of velocities suggest that the current convergence rate accommodated across the Hellenic trench is ˜35 mm/yr, in agreement with McClusky et al. (2000, 2003). No shortening perpendicular to the trench is found between sites located in the southern Peloponnese and Crete relative to sites located further landward. The results are compared to the seismicity of the region in order to reassess the ratio of seismic and aseismic deformation. Moreover, the geodetic results confirm the presence of strike-parallel spreading along the arc at ˜3.5 mm/yr between south-western Peloponnese and western Crete, which correlates with several extensional structures described by Armijo et al. (1992) and earthquake focal mechanisms.

  17. Mapping urban forest tree species using IKONOS imagery: preliminary results.

    PubMed

    Pu, Ruiliang

    2011-01-01

    A stepwise masking system with high-resolution IKONOS imagery was developed to identify and map urban forest tree species/groups in the City of Tampa, Florida, USA. The eight species/groups consist of sand live oak (Quercus geminata), laurel oak (Quercus laurifolia), live oak (Quercus virginiana), magnolia (Magnolia grandiflora), pine (species group), palm (species group), camphor (Cinnamomum camphora), and red maple (Acer rubrum). The system was implemented with soil-adjusted vegetation index (SAVI) threshold, textural information after running a low-pass filter, and brightness threshold of NIR band to separate tree canopies from non-vegetated areas from other vegetation types (e.g., grass/lawn) and to separate the tree canopies into sunlit and shadow areas. A maximum likelihood classifier was used to identify and map forest type and species. After IKONOS imagery was preprocessed, a total of nine spectral features were generated, including four spectral bands, three hue-intensity-saturation indices, one SAVI, and one texture image. The identified and mapped results were examined with independent ground survey data. The experimental results indicate that when classifying all the eight tree species/ groups with the high-resolution IKONOS image data, the identifying accuracy was very low and could not satisfy a practical application level, and when merging the eight species/groups into four major species/groups, the average accuracy is still low (average accuracy = 73%, overall accuracy = 86%, and κ = 0.76 with sunlit test samples). Such a low accuracy of identifying and mapping the urban tree species/groups is attributable to low spatial resolution IKONOS image data relative to tree crown size, to complex and variable background spectrum impact on crown spectra, and to shadow/shaded impact. The preliminary results imply that to improve the tree species identification accuracy and achieve a practical application level in urban area, multi-temporal (multi

  18. Preliminary Results of the Effect of Microgravity on Seated Height

    NASA Technical Reports Server (NTRS)

    Rajulu, Sudhakar; Young, Karen; Mesloh, Miranda

    2011-01-01

    The new vehicle for future space travel to the International Space Station (ISS) and beyond will be highly dependent on the seat layout. A primary concern with the seat layout design of the new vehicle is the amount of seated height growth that occurs in space; this could cause a major accommodation issue. The design of the seats, seat layout, suit fit, and crew accommodation are all critically affected due to the increase in height that occurs in microgravity. The increase in height due to spinal elongation caused by the absence of gravity could lead to inadequate clearances that would have implications for the ability of crewmembers to return safely or to conduct nominal operations during the mission. This study was designed to reduce the risk of inadequate design of the vehicle, environment, tools, equipment, etc. (SHFE risk 2.3.1.1) and safely return crewmembers to earth from low-earth orbit travel, ISS, and beyond. In order to safely return the crewmembers, the design requirements must anticipate microgravity growth, elongation of the spine, bone and muscle loss, fluid shifts, etc. Thus, this study is to determine the amount of torso growth (spinal elongation) for a seated posture during Shuttle and ISS missions. Crewmembers seated heights were collected before, during, and after spaceflight to quantify the amount of growth that occurred as a result of microgravity. The changes in seated height will provide the designers with a design requirement which allows for change in spinal growth for a seated posture. Preliminary results have shown that , during flight, seated height increases by a range of approximately 2-6 percent compared to pre-launch seated height.

  19. Preliminary results of the XR2-1 experiment

    SciTech Connect

    Gauntt, R.O.; Helmick, P.H.; Humphries, L.

    1996-03-01

    The XR2-1 (Ex-Reactor) experiment, investigating metallic core-melt relocation in boiling water reactor geometry, was performed on October 12, 1995, following two previous simpler XR1-series tests in August and November of 1993. The XR2-1 test made use of a highly detailed replication of the lower region of the BWR core, including the control blade and channel box structures, fuel rods, fuel canister nosepieces, control blade velocity limiter, and fuel support pieces, in order to investigate a key core melt progression uncertainty for BWR Station Blackout type accidents. The purpose of this experiment program is to examine the behavior of downward-draining molten metallic core materials in a severe reactor accident in a dry BWR core, and to determine conditions under which the molten materials drain out of the core region, or freeze to form blockages in the lower portion of the core. In the event that the draining metallic materials do not form stable blockages in the lower core region, and instead erode the lower core structures such as the lower core plate, then the subsequent core melt progression processes may proceed quite differently than was observed in the TMI-2 accident, with correspondingly different impact on vessel loading and vessel release behavior. The results of the Ex-Reactor tests are preliminary. All of the tests conducted have shown a significant degree of channel box destruction induced by the draining control blade materials. The XR2-1 test further showed that the draining zircaloy melt causes significant disruption of the fuel rod geometry. All of the tests have shown tendencies to form interim blockages as the melts temporarily freeze, but that these blockages re-melt, assisted by eutectic interactions, resulting in the sudden draining of accumulated metallic melt pools.

  20. Transforming Growth Factor β-1 (TGF-β1) Is a Serum Biomarker of Radiation Induced Fibrosis in Patients Treated With Intracavitary Accelerated Partial Breast Irradiation: Preliminary Results of a Prospective Study

    SciTech Connect

    Boothe, Dustin L.; Coplowitz, Shana; Greenwood, Eleni; Barney, Christian L.; Christos, Paul J.; Parashar, Bhupesh; Nori, Dattatreyudu; Chao, K. S. Clifford; Wernicke, A. Gabriella

    2013-12-01

    Purpose: To examine a relationship between serum transforming growth factor β -1 (TGF-β1) values and radiation-induced fibrosis (RIF). Methods and Materials: We conducted a prospective analysis of the development of RIF in 39 women with American Joint Committee on Cancer stage 0-I breast cancer treated with lumpectomy and accelerated partial breast irradiation via intracavitary brachytherapy (IBAPBI). An enzyme-linked immunoassay (Quantikine, R and D, Minneapolis, MN) was used to measure serum TGF-β1 before surgery, before IBAPBI, and during IBAPBI. Blood samples for TGF-β1 were also collected from 15 healthy, nontreated women (controls). The previously validated tissue compliance meter (TCM) was used to objectively assess RIF. Results: The median time to follow-up for 39 patients was 44 months (range, 5-59 months). RIF was graded by the TCM scale as 0, 1, 2, and 3 in 5 of 20 patients (25%), 6 of 20 patients (30%), 5 of 20 patients (25%), and 4 of 20 patients (20%), respectively. The mean serum TGF-β1 values were significantly higher in patients before surgery than in disease-free controls, as follows: all cancer patients (30,201 ± 5889 pg/mL, P=.02); patients with any type of RIF (32,273 ± 5016 pg/mL, P<.0001); and women with moderate to severe RIF (34,462 ± 4713 pg/mL, P<0.0001). Patients with moderate to severe RIF had significantly elevated TGF-β1 levels when compared with those with none to mild RIF before surgery (P=.0014) during IBAPBI (P≤0001), and the elevation persisted at 6 months (P≤.001), 12 months (P≤.001), 18 months (P≤.001), and 24 months (P=.12). A receiver operating characteristic (ROC) curve of TGF-β1 values predicting moderate to severe RIF was generated with an area under the curve (AUC){sub ROC} of 0.867 (95% confidence interval 0.700-1.000). The TGF-β1 threshold cutoff was determined to be 31,000 pg/mL, with associated sensitivity and specificity of 77.8% and 90.0%, respectively. Conclusions: TGF-β1 levels correlate with

  1. Preliminary Characterization Results from the DebriSat Project

    NASA Technical Reports Server (NTRS)

    Rivero, M.; Shiotani, B.; Kleespies, J.; Toledo-Burdett, R.; Moraguez, M.; Carrasquila, M.; Fitz-Coy, N.; Liou, J.-C.; Sorge, M.; Huynh, T.

    2016-01-01

    preliminary results presented. Additionally, lessons learned from the implemented automations and their impacts on the integrity of the results are discussed.

  2. COSMIC EVOLUTION OF DUST IN GALAXIES: METHODS AND PRELIMINARY RESULTS

    SciTech Connect

    Bekki, Kenji

    2015-02-01

    We investigate the redshift (z) evolution of dust mass and abundance, their dependences on initial conditions of galaxy formation, and physical correlations between dust, gas, and stellar contents at different z based on our original chemodynamical simulations of galaxy formation with dust growth and destruction. In this preliminary investigation, we first determine the reasonable ranges of the most important two parameters for dust evolution, i.e., the timescales of dust growth and destruction, by comparing the observed and simulated dust mass and abundances and molecular hydrogen (H{sub 2}) content of the Galaxy. We then investigate the z-evolution of dust-to-gas ratios (D), H{sub 2} gas fraction (f{sub H{sub 2}}), and gas-phase chemical abundances (e.g., A {sub O} = 12 + log (O/H)) in the simulated disk and dwarf galaxies. The principal results are as follows. Both D and f{sub H{sub 2}} can rapidly increase during the early dissipative formation of galactic disks (z ∼ 2-3), and the z-evolution of these depends on initial mass densities, spin parameters, and masses of galaxies. The observed A {sub O}-D relation can be qualitatively reproduced, but the simulated dispersion of D at a given A {sub O} is smaller. The simulated galaxies with larger total dust masses show larger H{sub 2} and stellar masses and higher f{sub H{sub 2}}. Disk galaxies show negative radial gradients of D and the gradients are steeper for more massive galaxies. The observed evolution of dust masses and dust-to-stellar-mass ratios between z = 0 and 0.4 cannot be reproduced so well by the simulated disks. Very extended dusty gaseous halos can be formed during hierarchical buildup of disk galaxies. Dust-to-metal ratios (i.e., dust-depletion levels) are different within a single galaxy and between different galaxies at different z.

  3. Mapping Antarctica using Landsat-8 - the preliminary results

    NASA Astrophysics Data System (ADS)

    Cheng, X.; Hui, F.; Qi, X.

    2014-12-01

    The first Landsat Image Mosaic of Antarctica (LIMA) was released in 2009, which was created by USGS, BAS, and NASA from more than 1,000 Landsat ETM+ scenes. As the first major scientific outcome of the IPY, LIMA supports current scientific polar research, encourages new projects, and helps the general public visualize Antarctica and changes happening to this southernmost environment. As the latest satellite of Landsat mission, the Landsat-8 images the entire Earth every 16 days in an 8-day offset from Landsat-7. Data collected by the instruments onboard the satellite are available to download at no charge within 24 hours of reception. The standard Landsat 8 products provided by the USGS EROS Center consist of quantized and calibrated scaled Digital Numbers (DN) in 16-bit unsigned integer format and can be rescaled to the Top Of Atmosphere (TOA) reflectance and/or radiance. With the support of USGS portal, we searched and downloaded more than 1600 scenes of Level 1 T- Terrain Corrected Landsat 8 image products covering Antarctica from late 2013 to early 2014. These data were converted to planetary radiance for further processing. Since the distribution of clouds in these images are random and much complicated, statistics on the distribution of clouds were performed and then help to decide masking those thicker cloud to keep more useful information left and avoid observation holes. A preliminary result of the Landsat-8 mosaic of Antarctica under the joint efforts of Beijing Normal University, NSIDC and University of Maryland will be released on this AGU fall meeting. Comparison between Landsat 7 and 8 mosaic products will also be done to find the difference or advantage of the two products.

  4. Environment modelling in near Earth space: Preliminary LDEF results

    NASA Technical Reports Server (NTRS)

    Coombs, C. R.; Atkinson, D. R.; Wagner, J. D.; Crowell, L. B.; Allbrooks, M.; Watts, A. J.

    1992-01-01

    Hypervelocity impacts by space debris cause not only local cratering or penetrations, but also cause large areas of damage in coated, painted or laminated surfaces. Features examined in these analyses display interesting morphological characteristics, commonly exhibiting a concentric ringed appearance. Virtually all features greater than 0.2 mm in diameter possess a spall zone in which all of the paint was removed from the aluminum surface. These spall zones vary in size from approximately 2 - 5 crater diameters. The actual craters in the aluminum substrate vary from central pits without raised rims, to morphologies more typical of craters formed in aluminum under hypervelocity laboratory conditions for the larger features. Most features also possess what is referred to as a 'shock zone' as well. These zones vary in size from approximately 1 - 20 crater diameters. In most cases, only the outer-most layer of paint was affected by this impact related phenomenon. Several impacts possess ridge-like structures encircling the area in which this outer-most paint layer was removed. In many ways, such features resemble the lunar impact basins, but on an extremely reduced scale. Overall, there were no noticeable penetrations, bulges or spallation features on the backside of the tray. On Row 12, approximately 85 degrees from the leading edge (RAM direction), there was approximately one impact per 15 cm(exp 2). On the trailing edge, there was approximately one impact per 72 cm(exp 2). Currently, craters on four aluminum experiment trays from Bay E09, directly on the leading edge are being measured and analyzed. Preliminary results have produced more than 2200 craters on approximately 1500 cm(exp 2) - or approximately 1 impact per 0.7 cm(exp 2).

  5. Preliminary results of spectral reflectance studies of tycho crater

    NASA Technical Reports Server (NTRS)

    Hawke, B. R.; Coombs, C. R.; Lucey, P. G.; Bell, J. F.; Jaumann, R.; Neukum, G.; Pieters, Carle M.

    1987-01-01

    The preliminary analysis and interpretation of near infrared spectra obtained for both the interior and exterior deposits associated with the Tycho crater is presented. Specific objectives were: (1) to determine the composition and stratigraphy of the highland crust in the Tycho target site; (2) to determine the likely composition of the primary ejecta which may be present in ray deposits; (3) to investigate the nature of spectral units defined in previous studies; (4) to further investigate the nature and origin of both the bright and dark haloes around the rim crest; and (5) to compare the compositions determined for the Tycho units with those of the Aristarchus crater as well as typical highland deposits. The spectra obtained for the interior areas exhibit similar spectral features. These include relatively strong 1 micron absorption bands whose minima are centered between 0.97 and 0.99 microns and shallow to intermediate continuum slopes. The spectra generally exhibit indications of a 1.3 micron feature consistent with the presence of Fe(2+) bearing plagioclase feldspar. The strong 1 micron absorption features indicate a dominant high Ca clinopyroxene component. Results obtained from the ejecta deposits show that the spectrum of the inner, bright halo is almost identical with those obtained for interior units. The spectrum of the dark halo exhibits a wide, relatively shallow absorption feature centered at 1.01 microns, a 1.3 micron absorption, and a steep continuum slope. This spectrum is interpreted as indicating the presence of pyroxene, Fe-bearing feldspar, and a significant component of Fe-bearing impact melt glass. Finally, the spectra of spots inside Tycho show similarity with certain spectra for Aristarchus. However, the suite of spectra obtained for Tycho exhibits a different trend in terms of band center versus width.

  6. Autonomous Ozone and Aerosol Lidar Platform: Preliminary Results

    NASA Astrophysics Data System (ADS)

    Strawbridge, K. B.

    2014-12-01

    Environment Canada is developing an autonomous tropospheric ozone and aerosol lidar system for deployment in support of short-term field studies. Tropospheric ozone and aerosols (PM10 and PM2.5) are important atmospheric constituents in low altitude pollution affecting human health and vegetation. Ozone is photo-chemically active with nitrogen oxides and can have a distinct diurnal variability. Aerosols contribute to the radiative budget, are a tracer for pollution transport, undergo complex mixing, and contribute to visibility and cloud formation. This particular instrument will employ two separate lidar transmitter and receiver assemblies. The tropospheric ozone lidar, based on the differential absorption lidar (DIAL) technique, uses the fourth harmonics of a Nd:YAG laser directed into a CO2 Raman cell to produce 276 nm, 287nm and 299 nm (first to third Stokes lines) output wavelengths. The aerosol lidar is based on the 3+2 design using a tripled Nd:YAG to output 355 nm, 532 nm and 1064nm wavelengths. Both lidars will be housed in a modified cargo trailer allowing for easy deployment to remote areas. The unit can be operated and monitored 24 hours a day via an internet link and requires an external power source. Simultaneous ozone and aerosol lidar measurements will provide the vertical context necessary to understand the complex mixing and transformation of pollutants - particularly when deployed near other ground-based in-situ sensors. Preliminary results will be shown from a summer field study at the Centre For Atmospheric Research Experiments (CARE).

  7. Magnetic Resonance Elastography of Liver Tumors- Preliminary Results

    PubMed Central

    Venkatesh, Sudhakar K; Yin, Meng; Glockner, James F; Takahashi, Naoki; Araoz, Philip A; Talwalkar, Jayant A; Ehman, Richard L

    2010-01-01

    Aim To evaluate the potential value of magnetic resonance elastography (MRE) for characterizing solid liver tumors. Materials and Methods Forty-four liver tumors (metastases-14, hepatocellular carcinoma- 12, hemangioma-9, cholangiocarcinoma-5, focal nodular hyperplasia-3, and hepatic adenoma-1) were evaluated with MRE. MRE was performed on a 1.5 T scanner with a modified phase-contrast, gradient echo sequence to collect axial wave images sensitized along the through-plane motion direction. The tumors were identified in T2-, T1-weighted and gadolinium enhanced T1-weighted images and the MRE images were obtained through the tumor. A stiffness map (elastogram) was generated by an automated process using an inversion algorithm. The mean shear stiffness of the tumor was calculated using a manually specified region of interest placed over the tumor in the stiffness map. The stiffness value of non-tumor bearing hepatic parenchyma was also calculated. Statistical analysis was performed on the stiffness values for differentiation between normal liver, fibrotic liver, benign tumors and malignant tumors. Results Malignant liver tumors had significantly higher mean shear stiffness than benign tumors, fibrotic liver and normal liver (10.1kPa vs. 2.7kpa (p<0.001), vs. 5.9kPa (p<0.001) and vs. 2.3kPa (p<0.001) respectively). Fibrotic livers had stiffness values overlapping both the benign and malignant tumors. Cut-off values of 5kPa accurately differentiate malignant tumors from benign tumors and normal liver parenchyma in this preliminary investigation. Conclusions MR elastography is a promising, non-invasive technique for assessing solid liver tumors. MRE may provide new, quantitative tissue characterization parameters for differentiating benign and malignant liver tumors. PMID:18492904

  8. Transforming Growth Factor Beta-1 (TGF-β1) is a Serum Biomarker of Radiation Induced Fibrosis in Patients Treated with Intracavitary Accelerated Partial Breast Irradiation (IBAPBI): Preliminary Results of a Prospective Study

    PubMed Central

    Boothe, Dustin L.; Coplowitz, Shana; Greenwood, Eleni; Christos, Paul J.; Parashar, Bhupesh; Nori, Dattatreyudu; Chao, KS Clifford; Wernicke, A. Gabriella

    2014-01-01

    Purpose To examine a relationship between serum transforming growth factor beta-1 (TGF-β1) values and radiation induced fibrosis (RIF). Methods We conducted a prospective analysis of development of RIF in 38 women with AJCC Stage 0-I breast cancer treated with lumpectomy and accelerated partial breast irradiation via interstitial brachytherapy (IBAPBI). An ELISA (Quantikine ®, R&D, MN) immunoassay was used to measure serum TGF-β1 pre-surgery, pre- IBAPBI, and during IBAPBI. Blood samples for TGF-β1 were also collected from 15 healthy, non-treated women (controls). The previously validated tissue compliance meter (TCM) was used to objectively assess radiation-induced fibrosis (RIF). Results Median time to follow-up for 38 patients is 44 months (range, 5 – 59 months). RIF is graded by the TCM scale as 0, 1, 2 and 3 in 5/20 (25%), 6/20 (30%), 5/20 (25%) and 4/20 (20%) patients, respectively. ΔTCM ≥6mm (moderate-to-severe RIF) is statistically different from ΔTCM ≤3mm (none-to-mild RIF) (p<0.05). Mean serum TGF-β1 values are significantly higher in patients pre-surgery than disease-free controls in: a) all cancer patients (30,201 ± 5,889 pg/ml, p=0.02), b) patients with any type of RIF (32,273 ± 5,016 pg/ml, p<0.0001) and c) women with moderate-to-severe RIF (34,462 ± 4,713 pg/ml, p<0.0001). The post-IBAPBI mean serum TGF-β1 is 21,915pg/ml in patients with ΔTCM ≥6mm (moderate-severe RIF). This is significantly higher than the mean serum TGF-β1, 14,940pg/ml, in patients with ΔTCM ≤3mm (p = 0.036). In patients who develop moderate-to-severe RIF, pre-IAPBI mean TGF-β1 values are also predictive of this sequela (17,885 ± 3,952 pg/ml, p=0.007). Conclusions TGF-β1 levels correlate with development of moderate-to-severe RIF. The pre-IBAPBI mean TGF-β1 levels can serve as an early biomarker for development of moderate-to-severe RIF after IBAPBI PMID:24139518

  9. Mycodiversity in marine sediments contaminated by heavy metals: preliminary results

    NASA Astrophysics Data System (ADS)

    Zotti, Mirca; Carbone, Cristina; Cecchi, Grazia; Consani, Sirio; Cutroneo, Laura; Di Piazza, Simone; Gabutto, Giacomo; Greco, Giuseppe; Vagge, Greta; Capello, Marco

    2016-04-01

    .6 CFU per gram of sediments. The maximum value of 11 CFU g-1 has been recorded in two stations (off the Sestri Levante Tombolo), while the minimum value has been recorded closer to the coast. As concern qualitative results, the most recurrent genera are Aspergillus and Penicillium. These data confirm the occurrence of a mycobiota in these heavy metal contaminated sediments. Our preliminary results are a first contribution to the knowledge of presence of microfungi in marine sediments, and propel us to increase our research in order to find out new organisms for bioremediation purpose.

  10. Toward DNA-based facial composites: preliminary results and validation.

    PubMed

    Claes, Peter; Hill, Harold; Shriver, Mark D

    2014-11-01

    The potential of constructing useful DNA-based facial composites is forensically of great interest. Given the significant identity information coded in the human face these predictions could help investigations out of an impasse. Although, there is substantial evidence that much of the total variation in facial features is genetically mediated, the discovery of which genes and gene variants underlie normal facial variation has been hampered primarily by the multipartite nature of facial variation. Traditionally, such physical complexity is simplified by simple scalar measurements defined a priori, such as nose or mouth width or alternatively using dimensionality reduction techniques such as principal component analysis where each principal coordinate is then treated as a scalar trait. However, as shown in previous and related work, a more impartial and systematic approach to modeling facial morphology is available and can facilitate both the gene discovery steps, as we recently showed, and DNA-based facial composite construction, as we show here. We first use genomic ancestry and sex to create a base-face, which is simply an average sex and ancestry matched face. Subsequently, the effects of 24 individual SNPs that have been shown to have significant effects on facial variation are overlaid on the base-face forming the predicted-face in a process akin to a photomontage or image blending. We next evaluate the accuracy of predicted faces using cross-validation. Physical accuracy of the facial predictions either locally in particular parts of the face or in terms of overall similarity is mainly determined by sex and genomic ancestry. The SNP-effects maintain the physical accuracy while significantly increasing the distinctiveness of the facial predictions, which would be expected to reduce false positives in perceptual identification tasks. To the best of our knowledge this is the first effort at generating facial composites from DNA and the results are preliminary

  11. Preliminary Results from an Hydroacoustic Experiment in the Indian Ocean

    NASA Astrophysics Data System (ADS)

    Royer, J.; Dziak, R. P.; Delatre, M.; Brachet, C.; Haxel, J. H.; Matsumoto, H.; Goslin, J.; Brandon, V.; Bohnenstiehl, D. R.; Guinet, C.; Samaran, F.

    2008-12-01

    We report initial results from a 14-month hydroacoustic experiment in the Indian Ocean conducted by CNRS/University of Brest and NOAA/Oregon State University. The objective was to monitor the low-level seismic activity associated with the three contrasting spreading ridges and deforming zones in the Indian Ocean. Three autonomous hydrophones, moored in the SOFAR channel, were deployed in October 2006 and recovered early 2008 by R/V Marion Dufresne, in the Madagascar Basin, and northeast and southwest of Amsterdam Island, complementing the two permanent hydroacoustic stations of the Comprehensive nuclear-Test-Ban Treaty Organization (CTBTO) located near Diego Garcia Island and off Cape Leeuwin. Our temporary network detected more than 2000 events. Inside the array, we located 592 events (compared to 49 in the NEIC earthquake catalog) with location errors less than 5 km and time error less than 2s. The hydrophone array detected on average 5 to 40 times more events per month than land-based networks. First-order observations indicate that hydroacoustic seismicity along the Southeast Indian ridge (SEIR) occurs predominantly along the transform faults. The Southwest Indian Ridge exhibits some periodicity in earthquake activity between adjacent ridge segments. Two large tectonic/volcanic earthquake swarms are observed along the Central Indian Ridge (near the triple junction) in September and December 2007. Moreover, many off ridge-axis events are also observed both south and north of the SEIR axis. Improved localization using the CTBTO records will help refine these preliminary results and further investigate extended volcanic sequences along the SEIR east of 80°E and other events outside of the temporary array. The records also display numerous vocalizations of baleen whales in the 20-40Hz bandwidth. The calls are attributed to fin whales, Antarctic blue whales and pygmy blue whales of Madagascar and Australian type. Their vocal activity is found to be highly seasonal

  12. Monitoring of a slope affected by shallow landslides: preliminary results

    NASA Astrophysics Data System (ADS)

    Meisina, Claudia; Zizioli, Davide; Bordoni, Massimiliano; Valentino, Roberto; Bittelli, Marco; Chersich, Silvia

    2013-04-01

    pluviometer, a thermo-hygrometer, a barometer, a sonic anemometer and a net radiometer. Six TDR probes (Time Domain Reflectometer) are installed at 0.2, 0.4, 0.6, 1, 1.2, 1.4 meters from ground level to measure the soil volumetric water content. To measure soil matric suction three tensiometers and three heat dissipation sensors are installed at 0.2, 0.6, 1.2 meters from ground level. The data are collected by a CR1000 datalogger (Campbell Sci. Inc.) every 10 minutes. In this work preliminary results obtained from 12 months of monitoring are presented: emphasis is given to the response of the cover materials after dry and wet periods in terms of soil water content and matric potential. These results will be linked to determine the hydro-geotechnical processes that could predispose the triggering of shallow landslides.

  13. Anisotropy of Pore Structure and Permeability in Granite: Preliminary Results

    NASA Astrophysics Data System (ADS)

    Onishi, C. T.; Shimizu, I.; Mizoguchi, K.; Uehara, S.; Shimamoto, T.

    2001-12-01

    of 25- 200 MPa, with pore pressure kept around 20 MPa. Preliminary results indicate relatively high permeability for undeformed biotite granite, about 10-16m2 at the initial confining pressure (Pc=30MPa), and with a gradual decrease to 10-17m2 at the highest Pc(=198MPa). The fractured sample with cataclastic seams has lower permeability (in the order of 10-17 to 10-18m2) possibly due to crack sealing by hydrothermal activities.

  14. Some Preliminary Scientific Results of Chang'E-3 Mission

    NASA Astrophysics Data System (ADS)

    Zou, Y.; Li, W.; Zheng, Y.; Li, H.

    2015-12-01

    Chang'E-3 mission is the main task of Phase two of China Lunar Exploration Program (CLEP), and also is Chinese first probe of landing, working and roving on the moon. Chang'E-3 craft composed of a lander and a rover, and each of them carry four scientific payloads respectively. The landing site of Chang'E-3 was located at 44.12 degrees north latitude and 19.51 degrees west longitude, where is in the northern part of Imbrium Which the distance in its west direction from the landing site of former Soviet probe Luna-17 is about 400 km, and about 780km far from the landing site of Appolo-17 in its southeast direction. Unfortunately, after a series of scientific tests and exploration on the surface of the moon, the motor controller communication of the rover emerged a breakdown on January 16, 2014, which leaded the four payloads onboard the rover can't obtain data anymore. However, we have received some interesting scientific data which have been studied by Chinese scientists. During the landing process of Chang'E-3, the Landing camera got total 4673 images with the Resolution in millimeters to meters, and the lander and rover took pictures for each other at different point with Topography camera and Panoramic camera. We can find characteristic changes in celestial brightness with time by analyzing image data from Lunar-based Ultraviolet Telescope (LUT) and an unprecedented constraint on water content in the sunlit lunar exosphere seen by LUT). The figure observed by EUV camera (EUVC) shows that there is a transient weak area of the Earth's plasma sphere; This event took place about three hours. The scientists think that it might be related to the change of the particle density of mid-latitude ionosphere. The preliminary spectral and mineralogical results from the landing site are derived according to the data of Visible and Near-infrared Imaging Spectrometer (VNIS). Seven major elements including Mg, Al, Si, K, Ca, Ti and Fe have been identified by the Active Particle

  15. Mapping the contours of the Local bubble: preliminary results

    NASA Astrophysics Data System (ADS)

    Sfeir, D. M.; Lallement, R.; Crifo, F.; Welsh, B. Y.

    1999-06-01

    We present preliminary results from a long-term program of mapping the neutral absorption characteristics of the local interstellar medium, taking advantage of Hipparcos stellar distances. Equivalent widths of the NaI D-line doublet at 5890 Å are presented for the lines-of-sight towards some 143 new target stars lying within 300 pc of the Sun. Using these data which were obtained at the Observatoire de Haute Provence, together with previously published NaI absorption measurements towards a further 313 nearby targets, we present absorption maps of the distribution of neutral gas in the local interstellar medium as viewed from 3 different galactic projections. In particular, these maps reveal the Local Bubble region as a low neutral density interstellar cavity in the galactic plane with radii between 65-250 pc that is surrounded by a (dense) neutral gas boundary (or ``wall''). We have compared our iso-column contours with the contours derived by Snowden et al. (\\cite{snowden98}) using ROSAT soft X-ray emission data. Consistency in the global dimensions derived for both sets of contours is found for the case of a million degree hot LB plasma of emissivity 0.0023 cm(-6) pc with an electron density of 0.005 cm(-2) . We have detected only one relatively dense accumulation of cold, neutral gas within 60 pc of the Sun that surrounds the star delta Cyg, and note that the nearest molecular cloud complex of MBM 12 probably resides at the very edge of the Local Bubble at a distance of ~ 90 pc. Our observations may also explain the very different physical properties of the columns of interstellar gas in the line-of-sight to the two hot stars epsilon CMa and beta CMa as being due to their locations with respect to the Bubble contours. Finally, in the meridian plane the LB cavity is found to be elongated perpendicularly to the Gould's Belt plane, possibly being ``squeezed'' by the expanding shells of the Sco-Cen and Perseus-Taurus OB associations. Tables 1 and 2 are also

  16. Preliminary results of LISM/SELENE (Kaguya); current status

    NASA Astrophysics Data System (ADS)

    Honda, Chikatoshi; Haruyama, Junichi; Ohtake, Makiko; Matsunaga, Tsuneo; Morota, Tomokatsu; Yokota, Yasuhiro; Ogawa, Yoshiko; Torii, Masaya; Abe, Masanao; Lism Science Team

    The LISM (Lunar Imager / SpectroMeter), including the Terrain Camera (TC), Multi-band Imager (MI), and Spectral Profiler (SP) onboard SELENE (Kaguya), which was launched by an H-IIA launch vehicle on September 14, 2007, from Tanegashima Space Center in Japan, is an optical instrument suite. The first-light data of LISM for functional testing were successfully acquired on November 2, 2007 (UTC). The SELENE mission team made the transition to nominal observation from December 21, 2007, and the LISM data are currently being acquired without any problems. The TC 10-bit image data with a spatial resolution of about 10 m provide global DTMs with a relative height resolution of a few tens of meters or better, ultimately a DEM with absolute height information, and global or local high-contrast mosaicked maps for examination of detailed morphologies of the lunar surface and for age determination of such geological units using CSFDs or characteristics of degraded craters. The MI image data are acquired by a high-resolution multiband imaging camera consisting of visible sensors (415, 750, 900, and 1000 nm; 10-bit image) and near-infrared sensors (1000, 1050, 1250, and 1550 nm; 12- bit image). The spatial resolution of the visible sensors is 20m; that of the near-infrared sensors is 62 m. The MI data provide the global mineral distribution of the lunar surface such as olivine, pyroxene, plagioclase, and ilmenite. The SP has been obtaining continuous reflectance spectra of the lunar surface with broad spectral coverage (500 to 2600 nm), high spectral resolution (6 to 8 nm), and high spatial resolution (500 m). The SP data provide information on ironbearing minerals similar to MI data, and the horizontal distribution of fresh or space-weathered materials. We will describe the current LISM data processing, and some preliminary results of the LISM team, such as DTMs, age determinations, a part of mineral distribution and its spectra. These LISM (and other SELENE instrument data

  17. Preliminary results of a cosmic dust experiment on the moon

    NASA Technical Reports Server (NTRS)

    Berg, O. E.; Richardson, F. F.; Auer, S.; Rhee, J. W.

    1974-01-01

    A three-axis cosmic dust experiment placed on the lunar surface by the Apollo 17 crew is registering impact parameters of cosmic dust and lunar ejecta. A total of 1117 events have been recorded in eight months of data. Preliminary conclusions on the nature of the data include possible evidence of lunar soil transport associated with the terminators. Particle fluxes have been derived for two of the three sensor systems and for specified conditions of exposure.

  18. Preliminary Results from SCEC Earthquake Simulator Comparison Project

    NASA Astrophysics Data System (ADS)

    Tullis, T. E.; Barall, M.; Richards-Dinger, K. B.; Ward, S. N.; Heien, E.; Zielke, O.; Pollitz, F. F.; Dieterich, J. H.; Rundle, J. B.; Yikilmaz, M. B.; Turcotte, D. L.; Kellogg, L. H.; Field, E. H.

    2010-12-01

    realistic fault geometies and slip rates taken from California, excluding the Cascadia subduction zone. In order to make as close comparisons between the simulators as possible we have developed shared data formats for both input and output and a growing set of tools that can be used to make statistical comparisons between the simulator outputs. To date all five simulators have run a Northern California fault model and are in various stages of working on an All California fault model. The plan in the near future is to run them on the UCERF2 fault model. Initial comparisons show significant differences among the simulators and some differences from observed earthquake statistics. However, it is too early in the process to infer too much from these preliminary results. For example, the differences in how each simulator treats fault friction means that they may each need to use values for the assumed stress drops that are better tuned to their approach than are the common values used in the first comparison.

  19. Preliminary results of the PREFER FP7 Project

    NASA Astrophysics Data System (ADS)

    Fusilli, Lorenzo; Laneve, Giovanni; De Bonis, Roberto; Sebastian, Ana; Ferrucci, Fabrizio; Oliveira, Sandra

    2014-05-01

    The need to improve the information and intelligence support for forest fire prevention is widely recognized. Fire prevention is still the most cost-effective strategy when compared to firefighting and extinguishing that are costly, local, and triggered only in response to already ongoing crises. PREFER project, funded under the EU FP7 (G.A. 312931), intends to contribute at responding to such a pragmatic need of southern Europe's forests by: providing timely information products based on the exploitation of all available spacecraft sensors, offering a portfolio of products focused on pre- and post-crisis forest fire emergency, suitable for the users in the different countries of the European Mediterranean area. The PREFER Service portfolio consists of two main services: 1. Information Support to Fire Preparedness/Prevention Phase" (ISP) Service 2. Information Support to Fire Recovery/Reconstruction Phase" (ISR) Service This service is already at an advanced stage having completed the first year of activity. During this time several products have been consolidated: seasonal fuel maps; daily and seasonal fire hazard maps; seasonal risk maps; prescribed fire maps. This paper aims at presenting the preliminary results of the research activity carried out in the framework of the PREFER project, focusing, in particular, on these recalled above. As for Fire Risk and Hazard assessment, many indexes have been developed in the last years. Hardly any of them uses data derived from satellite images. The FPI index is an exception to this rule which, in addition, makes use of meteorological data. In spite of being a very complete index, the FPI still allows room for improvement which justify the interest of PREFER in it. PREFER's innovative approach to FPI will allow taking into account the effect of solar illumination conditions in determining the humidity present in the dead vegetation, and therefore its proneness to burn. PREFER innovation also focus in allowing the index to

  20. Ca Isotopic Ratios in Igneous Rocks: Some Preliminary Results

    NASA Astrophysics Data System (ADS)

    Huang, S.; Farkas, J.; Jacobsen, S. B.

    2009-12-01

    isotopic endmember. Specifically, among Hawaiian shield lavas, Makapuu-stage Koolau lavas have the lowest isotopic ratios of Nd, Hf and Pb , and the highest isotopic ratios of Sr and Os and olivine δ18O, and these observed isotopic characteristics are attributed to sampling recycled ancient oceanic crust (including sediments). Specifically, Makapuu-stage Koolau lavas have the highest Sr/Nb and La/Nb among Hawaiian lavas, which were interpreted as a result of sampling up to 3% recycled ancient carbonate-phosphate-rich sediments. Since ancient carbonates tend to have significantly lower 44Ca/40Ca than mantle value (up to 1 per mil), it is expected that Makapuu-stage Koolau lavas also have lower 44Ca/40Ca than other Hawiian shield lavas. Our preliminary Ca isotopic data confirmed this prediction. Specifically, Makapuu-stage Koolau lavas have slightly lower 44Ca/40Ca (average δ44/40Ca of 0.78±0.06, 2σ, n=4) than other Hawaiian lavas, mantle clinopyroxenes and nephelinites from the Oslo rift (average δ44/40Ca of 0.97±0.12, 2σ, n=17). The lighter 44Ca/40Ca observed in Makapuu-stage Koolau lavas can be explained as a result of adding 2-5% recycled ancient (2-3 Ga) carbonate into a typical mantle source. The amount of required ancient carbonate estimated based on Ca isotopes is comparable to those inferred using trace elements.

  1. Intensity Modulated Radiation Therapy for Primary Soft Tissue Sarcoma of the Extremity: Preliminary Results

    SciTech Connect

    Alektiar, Kaled M. . E-mail: alektiak@mskcc.org; Hong, Linda; Brennan, Murray F.; Della-Biancia, Cesar; Singer, Samuel

    2007-06-01

    Purpose: To report preliminary results on using intensity modulated radiation therapy (IMRT) as an adjuvant treatment in primary soft tissue sarcoma (STS) of the extremity. Methods and Materials: Between February 2002 and March 2005, 31 adult patients with primary STS of the extremity were treated with surgery and adjuvant IMRT. Tumor size was >10 cm in 74% of patients and grade was high in 77%. Preoperative IMRT was given to 7 patients (50 Gy) and postoperative IMRT (median dose, 63 Gy) was given to 24 patients. Complete gross resection including periosteal stripping or bone resection was required in 10, and neurolysis or nerve resection in 20. The margins were positive or within 1 mm in 17. Complications from surgery and radiation therapy (RT) were assessed using the Common Terminology Criteria for Adverse Events grading system. Results: Median follow-up time was 23 months. Grade 1 RT dermatitis developed in 71% of patients, Grade 2 in 16%, and Grade 3 in 10%. Infectious wound complications developed in 13% and noninfectious complications in 10%. Two patients (6.4%) developed fractures. Grade 1 neuropathy developed in 28% of patients and Grade 2 in 5%. The rates of Grade 1 and 2 joint stiffness were each 19%. Grade 1 edema was observed in 19% of patients and Grade 2 in 13%. The 2-year local control, distant control, and overall survival were 95%, 65%, and 81%, respectively. Conclusion: Intensity modulated RT appears to provide excellent local control in a difficult group of high-risk patients. The morbidity profile is also favorable, but longer follow-up is needed to confirm the results from this study.

  2. Radiative shocks on large scale lasers. Preliminary results

    NASA Astrophysics Data System (ADS)

    Leygnac, S.; Bouquet, S.; Stehle, C.; Barroso, P.; Batani, D.; Benuzzi, A.; Cathala, B.; Chièze, J.-P.; Fleury, X.; Grandjouan, N.; Grenier, J.; Hall, T.; Henry, E.; Koenig, M.; Lafon, J. P. J.; Malka, V.; Marchet, B.; Merdji, H.; Michaut, C.; Poles, L.; Thais, F.

    2001-05-01

    Radiative shocks, those structure is strongly influenced by the radiation field, are present in various astrophysical objects (circumstellar envelopes of variable stars, supernovae ...). Their modeling is very difficult and thus will take benefit from experimental informations. This approach is now possible using large scale lasers. Preliminary experiments have been performed with the nanosecond LULI laser at Ecole Polytechnique (France) in 2000. A radiative shock has been obtained in a low pressure xenon cell. The preparation of such experiments and their interpretation is performed using analytical calculations and numerical simulations.

  3. Optical scattering (TAOS) by tire debris particles: preliminary results

    NASA Astrophysics Data System (ADS)

    Crosta, Giovanni F.; Camatini, Marina C.; Zomer, Simeone; Holler, Stephen; Pan, Yongle; Bhaskara, Praveena; Muangchareon, Pongphisanu; Sung, Changmo; Cencetti, Simone; Regazzoni, Claudia

    2001-03-01

    Tire debris particles from low severity laboratory wear tests have been investigated by the TAOS optical scattering facility at Yale University. The incident wavelength is 532 nm. After the TAOS event some particle samples have been imaged by a scanning electron microscope and microanalyzed. The TAOS intensity patterns recorded within a solid angle in the backward sector have been processed by cluster analysis and compared with the patterns computed by a T-matrix code. Preliminary agreement has been found between TAOS data and the particle models (size, shape, refractive index). The purpose of the investigation is to obtain signatures of the material, based on its TAOS pattern.

  4. Preliminary results from the MINERvA experiment

    SciTech Connect

    Harris, Deborah A.; /Fermilab

    2011-11-01

    The MINERvA experiment, operating since 2009 in the NuMI neutrino beam line at Fermilab, has collected neutrino and antineutrino scattering data on a variety of nuclear targets. The detector is designed to identify events originating in plastic scintillator, lead, carbon, iron, water, and liquid helium. The goal of the experiment is to measure inclusive and exclusive cross sections for neutrino and antineutrino with much greater precision than previous experiments. We present preliminary kinematic distributions for charged current quasi-elastic scattering and other processes.

  5. Preliminary results on the conversion of laser energy into electricity

    NASA Technical Reports Server (NTRS)

    Thompson, R. W.; Manista, E. J.; Alger, D. L.

    1978-01-01

    A preliminary experiment was performed to investigate conversion of 10.6 micron laser energy to electrical energy via a laser-sustained argon plasma. Short-circuit currents of 0.7 A were measured between a thoriated-tungsten emitter and collector electrodes immersed in the laser-sustained argon plasma. Open-circuit voltages of about 1.5 V were inferred from the current-voltage load characteristics. The dominant mechanism of laser energy conversion is uncertain at this time. Much higher output powers appear possible.

  6. Experimental Studies of Ion Beam Neutralization: Preliminary Results

    SciTech Connect

    Ding, N.; Polansky, J.; Downey, R.; Wang, J.

    2011-05-20

    A testing platform is designed to study ion beam neutralization in the mesothermal, collisionless region. In the experimental setup, argon neutrals were ionized in a microwave cavity and accelerated by a plasma lens system which was biased to 2500 V above the system ground. Electrons were boiled off from two hot tungsten filaments to neutralize the ion beam. The plasma is diagnosed using Langmuir probe and Faraday probe. A 3-D traversing system and a complete data acquisition loop were developed to efficiently measure 3-D beam profile. Preliminary measurements of beam profiles are presented for different operating conditions.

  7. Ultraviolet observations of venus from mariner 10: preliminary results.

    PubMed

    Broadfoot, A L; Kumar, S; Belton, M J; McElroy, M B

    1974-03-29

    An objective grating spectrometer on Mariner 10 has measured air-glow in the wavelength range 200 to 1700 angstroms. The data reveal the presence of significant concentrations of hydrogen, helium, carbon, and oxygen atoms in the upper atmosphere of Venus. A preliminary analysis of the hydrogen data indicates an exospheric temperature of 400 degrees K. There is evidence for intense air-glow emission at wavelengths longward of 1350 angstroms; the nature of this emission is unclear, but the radiation is spatially extensive and detectable on both day and night sides of the planet. PMID:17791374

  8. Paleomagnetic dating of ferricretes in New Caledonia. Preliminary results.

    NASA Astrophysics Data System (ADS)

    Sevin, Brice; Ricordel-Prognon, Caroline; Quesnel, Florence; Cluzel, Dominique; Maurizot, Pierre; Robineau, Bernard

    2010-05-01

    Although the description of the emplacement (Cluzel et al., 2001) and the weathering (Trescases, 1975; Latham, 1986; Chevillotte et al., 2006) of the New Caledonia peridotites is well documented in the literature, the knowledge and the age of formation of the landsurfaces formed upon the ultrabasic massifs are poorly documented. Several surfaces have been recognised along the island but no reliable ages could be attributed to the associated regolith. In fact, the overthrust of the Ophiolitic Nappe in the South is stratigraphically constrained by a younger autochthonous olistostrom dated by Late Priabonian pelagic foraminifera (Cluzel et al., 1998). The supergene weathering being still active, the beginning of the ferruginisation of the various plateaux is not well constrained and estimated to have occurred between 34 Ma and Actual. The processes of absolute dating are not relevant to these weathering profiles (K-Mn oxides are poorly concentrated). Ferricretes and various ferruginous materials have the potential to record the ancient geomagnetic field providing means of age determination. In tropical soils, most of the primary remanence carring minerals are dissolved during weathering and secondary magnetic minerals, such as goethite and haematite, are formed in situ acquiring a crystallisation (or chemical) remanent magnetization (CRM). The paleomagnetic pole recovered by demagnetizing the CRMs are plotted on the local apparent polar wandering (APWP) reference curve providing an age for the different parts of the paleoweathering profiles. The data and interpretations we present here are based on paleomagnetic analysis of ferricretes of Goro and Tiebaghi. The preliminary results suggest, for the first time ever, well constrained ages between 20 and 25 Ma of major ferruginisation stages of the peridotites of New Caledonia. References Chevillotte V., Chardon D., Beauvais A, Maurizot P. & Colin F. (2006). Long-term tropical morphogenesis of New Caledonia (Southwest

  9. Preliminary results in large bone segmentation from 3D freehand ultrasound

    NASA Astrophysics Data System (ADS)

    Fanti, Zian; Torres, Fabian; Arámbula Cosío, Fernando

    2013-11-01

    Computer Assisted Orthopedic Surgery (CAOS) requires a correct registration between the patient in the operating room and the virtual models representing the patient in the computer. In order to increase the precision and accuracy of the registration a set of new techniques that eliminated the need to use fiducial markers have been developed. The majority of these newly developed registration systems are based on costly intraoperative imaging systems like Computed Tomography (CT scan) or Magnetic resonance imaging (MRI). An alternative to these methods is the use of an Ultrasound (US) imaging system for the implementation of a more cost efficient intraoperative registration solution. In order to develop the registration solution with the US imaging system, the bone surface is segmented in both preoperative and intraoperative images, and the registration is done using the acquire surface. In this paper, we present the a preliminary results of a new approach to segment bone surface from ultrasound volumes acquired by means 3D freehand ultrasound. The method is based on the enhancement of the voxels that belongs to surface and its posterior segmentation. The enhancement process is based on the information provided by eigenanalisis of the multiscale 3D Hessian matrix. The preliminary results shows that from the enhance volume the final bone surfaces can be extracted using a singular value thresholding.

  10. Diode laser supported partial nephrectomy in laparoscopic surgery: preliminary results

    NASA Astrophysics Data System (ADS)

    Sroka, Ronald; Hennig, Georg; Zillinberg, Katja; Khoder, Wael Y.

    2011-07-01

    Introduction: Warm ischemia and bleeding during laparoscopic partial nephrectomy place technical constraints on surgeons. Therefore it was the aim to develop a safe and effective laser assisted partial nephrectomy technique without need for ischemia. Patients and methods: A diode laser emitting light at 1318nm in cw mode was coupled into a bare fibre (core diameter 600 μm) thus able to transfer up to 100W to the tissue. After dry lab experience, a total of 8 patients suffering from kidney malformations underwent laparoscopic/retroperitoneoscopic partial nephrectomy. Clinically, postoperative renal function and serum c-reactive protein (CRP) were monitored. Laser induced coagulation depth and effects on resection margins were evaluated. Demographic, clinical and follow-up data are presented. Results: Overall interventions, the mean operative time was 116,5 minutes (range 60-175min) with mean blood loss of 238ml (range 50-600ml) while laser assisted resection of the kidney tissue took max 15min. After extirpation of the tumours all patients showed clinical favourable outcome during follow up period. The tumour size was measured to be 1.8 to 5cm. With respect to clinical safety and due to blood loos, two warm ischemia (19 and 24min) must be performed. Immediate postoperative serum creatinine and CRP were elevated within 0.1 to 0.6 mg/dl (mean 0.18 mg/dl) and 2.1-10 mg/dl (mean 6.24 mg/dl), respectively. The depth of the coagulation on the removed tissue ranged between <1 to 2mm without effect on histopathological evaluation of tumours or resection margin. As the surface of the remaining kidney surface was laser assisted coagulated after removal. The sealing of the surface was induced by a slightly larger coagulation margin, but could not measured so far. Conclusion: This prospective in-vivo feasibility study shows that 1318nm-diode laser assisted partial nephrectomy seems to be a safe and promising medical technique which could be provided either during open surgery

  11. No Detectable Hypoxia in Malignant Salivary Gland Tumors: Preliminary Results

    SciTech Connect

    Wijffels, Karien; Hoogsteen, Ilse J.; Lok, Jasper; Rijken, Paulus F.J.W.; Marres, Henri A.M.; Wilde, Peter C.M. de; Kogel, Albert J. van der; Kaanders, Johannes H.A.M.

    2009-04-01

    Purpose: Hypoxia is detected in most solid tumors and is associated with malignant progression and adverse treatment outcomes. However, the oxygenation status of malignant salivary gland tumors has not been previously studied. The aim of this study was to investigate the potential clinical relevance of hypoxia in this tumor type. Methods and Materials: Twelve patients scheduled for surgical resection of a salivary gland tumor were preoperatively injected with the hypoxia marker pimonidazole and the proliferation marker iododeoxyuridine. Tissue samples of the dissected tumor were immunohistochemically stained for blood vessels, pimonidazole, carbonic anhydrase-IX, glucose transporters-1 and -3 (Glut-1, Glut-3), hypoxia-inducible factor-1{alpha}, iododeoxyuridine, and epidermal growth factor receptor. The tissue sections were quantitatively assessed by computerized image analysis. Results: The tissue material from 8 patients was of sufficient quality for quantitative analysis. All tumors were negative for pimonidazole binding, as well as for carbonic anhydrase-IX, Glut-1, Glut-3, and hypoxia-inducible factor-1{alpha}. The vascular density was high, with a median value of 285 mm{sup -2} (range, 209-546). The iododeoxyuridine-labeling index varied from <0.1% to 12.2% (median, 2.2%). Epidermal growth factor receptor expression levels were mostly moderate to high. In one-half of the cases, nuclear expression of epidermal growth factor receptor was observed. Conclusion: The absence of detectable pimonidazole binding, as well as the lack of expression of hypoxia-associated proteins in all tumors, indicates that malignant salivary gland tumors are generally well oxygenated. It is unlikely that hypoxia is a relevant factor for their clinical behavior and treatment responsiveness.

  12. Geological evaluation of Radarsat data: Plans and preliminary results

    SciTech Connect

    Berger, Z.; Irving, R.E.L.; Thompson, M.D.

    1996-12-31

    Radarsat, the Canadian synthetic aperture radar satellite to be launched in September 1995, is anticipated to become the prime active imaging system for geological mapping of tropical areas and other humid areas. Radarsat will provide adequate spatial resolution, stereo capabilities and relatively low incidence angles to reduce the geometric distortions of geological structures due to layover effects. As part of the Radarsat User Development Program of the Canadian Space Agency, it has been proposed to conduct an evaluation program of the terrain surface mapping capabilities of Radarsat and its application to hydrocarbon exploration, coal development, geological hazard mapping and environmental monitoring. The evaluation program will be carried out in three test sites: (1) Western Canadian Basin (a mature exploration area in Alberta with a range of geology/topography), (2) Andean Foothills (frontier tropical sedimentary basins in Columbia representing prototype active exploration areas), and (3) Philippine volcanic region (frontier tropical earthquake-prone geohazard area of Philippine wrench fault system on Luzon Island, in a typical structural setting of the sedimentary basins of southeast Asia). The paper will include the project plans, illustrate the structural setting and the relationships between surface and subsurface structures for each of the three test sites, and present a preliminary evaluation of simulated and actual Radarsat data as compared to data from ERS-1, airborne SAR, Landsat Thematic Mapper and SPOT. The preliminary application of Radarsat for exploration will be discussed.

  13. Geological evaluation of Radarsat data: Plans and preliminary results

    SciTech Connect

    Berger, Z. ); Irving, R.E.L.; Thompson, M.D. )

    1996-01-01

    Radarsat, the Canadian synthetic aperture radar satellite to be launched in September 1995, is anticipated to become the prime active imaging system for geological mapping of tropical areas and other humid areas. Radarsat will provide adequate spatial resolution, stereo capabilities and relatively low incidence angles to reduce the geometric distortions of geological structures due to layover effects. As part of the Radarsat User Development Program of the Canadian Space Agency, it has been proposed to conduct an evaluation program of the terrain surface mapping capabilities of Radarsat and its application to hydrocarbon exploration, coal development, geological hazard mapping and environmental monitoring. The evaluation program will be carried out in three test sites: (1) Western Canadian Basin (a mature exploration area in Alberta with a range of geology/topography), (2) Andean Foothills (frontier tropical sedimentary basins in Columbia representing prototype active exploration areas), and (3) Philippine volcanic region (frontier tropical earthquake-prone geohazard area of Philippine wrench fault system on Luzon Island, in a typical structural setting of the sedimentary basins of southeast Asia). The paper will include the project plans, illustrate the structural setting and the relationships between surface and subsurface structures for each of the three test sites, and present a preliminary evaluation of simulated and actual Radarsat data as compared to data from ERS-1, airborne SAR, Landsat Thematic Mapper and SPOT. The preliminary application of Radarsat for exploration will be discussed.

  14. Percutaneous laser discectomy of cervical discs: preliminary clinical results.

    PubMed

    Siebert, W

    1995-06-01

    Thirty-one patients with herniated cervical discs were treated with PLDD from 1991 to 1993. In 1990, a few of these patients were treated with the Nd:YAG laser with no complications. Since 1991 we have used the holmium:YAG laser; 28 of the 31 patients experienced pain relief in a 6-week follow-up. PLDD for the cervical discs is a viable therapy. PMID:10150647

  15. Electromagnetic-Tracked Biopsy under Ultrasound Guidance: Preliminary Results

    SciTech Connect

    Hakime, Antoine Deschamps, Frederic; Marques De Carvalho, Enio Garcia; Barah, Ali; Auperin, Anne; Baere, Thierry De

    2012-08-15

    Purpose: This study was designed to evaluate the accuracy and safety of electromagnetic needle tracking for sonographically guided percutaneous liver biopsies. Methods: We performed 23 consecutive ultrasound-guided liver biopsies for liver nodules with an electromagnetic tracking of the needle. A sensor placed at the tip of a sterile stylet (18G) inserted in a coaxial guiding trocar (16G) used for biopsy was localized in real time relative to the ultrasound imaging plane, thanks to an electromagnetic transmitter and two sensors on the ultrasound probe. This allows for electronic display of the needle tip location and the future needle path overlaid on the real-time ultrasound image. Distance between needle tip position and its electronic display, number of needle punctures, number of needle pull backs for redirection, technical success (needle positioned in the target), diagnostic success (correct histopathology result), procedure time, and complication were evaluated according to lesion sizes, depth and location, operator experience, and 'in-plane' or 'out-of-plane' needle approach. Results: Electronic display was always within 2 mm from the real position of the needle tip. The technical success rate was 100%. A single needle puncture without repuncture was used in all patients. Pull backs were necessary in six patients (26%) to obtain correct needle placement. The overall diagnostic success rate was 91%. The overall true-positive, true-negative, false-negative, and failure rates of the biopsy were 100% (19/19) 100% (2/2), 0% (0/23), and 9% (2/23). The median total procedure time from the skin puncture to the needle in the target was 30 sec (from 5-60 s). Lesion depth and localizations, operator experience, in-plane or out-of-plane approach did not affect significantly the technical, diagnostic success, or procedure time. Even when the tumor size decreased, the procedure time did not increase. Conclusions: Electromagnetic-tracked biopsy is accurate to determine

  16. Cementless bulk alumina socket: preliminary results at 6 years.

    PubMed

    Hamadouche, M; Nizard, R S; Meunier, A; Bizot, P; Sedel, L

    1999-09-01

    To avoid polyethylene wear observed in total hip replacement, an alumina-alumina combination has been used since 1977. The aim of this study is to report the results of a hybrid alumina-alumina total hip arthroplasty with a cementless press-fit bulk alumina socket and a cemented titanium alloy stem in 55 patients (62 hips) operated on between 1982 and 1990. The bearing surfaces were a 32-mm alumina head articulating within the alumina socket. Four failures occurred: 3 aseptic loosenings of the socket and 1 femoral head fracture. Considering aseptic loosening as the endpoint, the survival rate was 93.2% after 6 years. At a mean of 72.1 months' follow-up, 92.4% of the surviving hips were graded as very good or good using the Merle d'Aubigné-Postel hip score. Radiolucent lines were observed on the acetabular side in 68.1 of the hips. The future of this interface, which is probably fibrous, remains questionable. With the exception of 1 femoral head fracture, all revisions were related to failure of the bony fixation of the socket, and no problem was encountered related to the alumina-alumina friction coupling. Alumina sockets with other types of cementless fixation have therefore been designed and are presently under clinical investigation. PMID:10512442

  17. Preliminary Results of the Extreme Ultraviolet Explorer Right Angle Program

    NASA Astrophysics Data System (ADS)

    McDonald, K.; Craig, N.; Sirk, M. M.; Drake, J. J.; Malina, R. F.

    1993-12-01

    During the guest observer phase of the EUVE Mission, data are being collected with the survey scanners and the Deep Survey Scanner. The EUVE Right Angle Program (RAP) involves the analysis of this data set and the coordination of possible simultaneous observations with ground based instruments. This data set consists of several discrete pointings performed at a much deeper level than the previous EUVE all-sky survey, although covering only a few percent of the sky. Analysis of this data set has detected a large number of previously undetected EUV sources. We present here a preliminary list of the sources observed during the EUVE Right Angle Program and compare properties of this list with properties of the EUVE Bright Source List. This work has been supported by NASA contract NAS5--30180.

  18. Design and preliminary test results of Daya Bay RPC modules*

    SciTech Connect

    Hackenburg, R.

    2011-09-01

    Resistive Plate Chamber (RPC) modules will be used as one part of the cosmic muon veto system in the Daya Bay reactor neutrino experiment. A total of 189 RPC modules will cover the three water pools in the experiment. To achieve track reconstruction and high efficiency, each module consists of 4 layers, each of which contains two sizes of bare chambers. The placement of bare chambers is reversed in different layers to reduce the overlapping dead areas. The module efficiency and patch efficiency were studied both in simulation and test of the data analysis. 143 modules have been constructed and tested. The preliminary study shows that the module and patch 3 out of 4 layers efficiency reaches about 98%.

  19. Preliminary Results on Lunar Interior Properties from the GRAIL Mission

    NASA Technical Reports Server (NTRS)

    Williams, James G.; Konopliv, Alexander S.; Asmar, Sami W.; Lemoine, H. Jay; Melosh, H. Jay; Neumann, Gregory A.; Phillips, Roger J.; Smith, David E.; Solomon, Sean C.; Watkins, Michael M.; Wieczorek, Mark A.; Zuber, Maria T.; Andrews-Hanna, Jeffrey C.; Head, James W.; Kiefer, Walter S.; Matsuyama, Isamu; McGovern, Patrick J.; Nimmo, Francis; Weber, Renee C.; Boggs, D. H.; Goossens, Sander J.; Kruizinga, Gerhard L.; Mazarico, Erwan; Park, Ryan S.; Yuan, Dah-Ning

    2013-01-01

    The Gravity Recovery and Interior Laboratory (GRAIL) mission has provided lunar gravity with unprecedented accuracy and resolution. GRAIL has produced a high-resolution map of the lunar gravity field while also determining tidal response. We present the latest gravity field solution and its preliminary implications for the Moon's interior structure, exploring properties such as the mean density, moment of inertia of the solid Moon, and tidal potential Love number k2. Lunar structure includes a thin crust, a deep mantle, a fluid core, and a suspected solid inner core. An accurate Love number mainly improves knowledge of the fluid core and deep mantle. In the future GRAIL will search for evidence of tidal dissipation and a solid inner core.

  20. 77 FR 17013 - Sodium Hexametaphosphate From the People's Republic of China: Preliminary Results of Second...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-23

    ... 15, 2012.\\3\\ \\1\\ See Initiation of Antidumping and Countervailing Duty Administrative Reviews, 76 FR... Hexametaphosphate From the People's Republic of China: Extension of Preliminary Results, 76 FR 73599 (November 29... China: Extension of Preliminary Results, 77 FR 6060 (February 7, 2012). Submissions by...

  1. Cytoxan, epirubicin, methotrexate and 5-fluorouracil with hormonal synchronization (tamoxifen/premarin) in advanced breast cancer. Preliminary results.

    PubMed

    Zaniboni, A; Simoncini, E; Marpicati, P; Gorni, F; Cervi, G C; Marini, G

    1986-10-01

    Thirty-three patients with advanced breast cancer were treated with combination chemotherapy and hormonal synchronization in an attempt to increase the overall response rate generally obtained with traditional modalities of treatment. Among the 31 evaluable patients 1 complete (3%), 7 partial (22%), 13 stable disease (42%) and 10 progression of disease (53%) were obtained. Side effects were quite manageable although there were two episodes of life-threatening hematological toxicity. Taking into account the poor prognostic characteristics of our patients (high percentage of dominant visceral disease, 21/31 previously treated patients), our preliminary results with this regimen are interesting and the treatment deserves further evaluation. PMID:3024851

  2. Serotonine and suicide: a preliminary study concerning a sample of violent suicidal patients.

    PubMed

    Cremniter, D; Thenault, M; Jamain, S; Meidinger, A; Delmas, C; Gaillard, M

    1994-09-01

    1. A sample of patients having attempted to commit suicide by using violent methods (hanging, jumping) was investigated according to the following procedure: for each patient, some evaluative tests (the MADRS, the SCL 90 and an agressivity scale) were administered and DSM III diagnosis was provided as well as the therapeutical orientation. 2. The 5 HIAA' level was measured in the CSF soon after the suicide attempt except for patients with rachis fracture or exposed to a cerebral oedeme. 3. Results were compared to those of a control group composed with patients having operated with rachi-anesthesia for orthopedic surgery. 4. The preliminary results show that 5 HIAA' levels were lower for suicide patients except for one schizophrenic patient. 5. This study suggests the possible link between a low 5 HIAA' level in CSF and the clinical aspects of severe suicidal behaviour. PMID:7526419

  3. Radioimmunodetection of non-Hodgkin`s lymphoma with radiolabelled LL2 monoclonal antibody. Preliminary results

    SciTech Connect

    Gasparini, M.; Buraggi, G.L.; Tondini, C.

    1994-05-01

    Radioimmunodetection (RAID) with 99m technetium labelled B cell lymphoma monoclonal antibody (MAb) (IMMU-LL2 Fab`, Immunomedics, Inc., Morris Plains, N.J.) was investigated in 8 patients (5 female and 3 male; age range 20-72 years) with histologically proven non-Hodgkin`s lymphoma (NHL). Of the 8 lymphomas, 5 were intermediate grade and 3 low grade. Whole body images with multiple planar views were obtained at 30 min, 4-6 and 24 hours after the I.V. injection of 1 mg LL2-Fab` labelled with 20-25 mCi (740-925 MBq) {sup 99}Tc. SPECT of chest or abdomen was performed at 5-8 hours after injection in all patients. No adverse reactions were observed in any patient after MAb infusion and no appreciable changes were seen in the blood counts, renal and liver function tests. A total of 17 of 18 (94.4%) lymphoma lesions were detected by RAID. All the tumor localizations were confirmed by clinical examination and with other imaging techniques, such as CT scan, MRI or gallium scan. In this series of patients no false positive results were noted and only 1 false negative resulted in a patient who had a mediastinal bulky disease. As regard the biodistribution of the immunoreagent we can make the following conclusions: (1) no appreciable bone marrow activity was seen, (2) splenic targeting was demonstrated in all patients, (3) tumor-to-non tumor ratios ranged from 1.2 to 2.8 as measured by ROI technique, (4) no difference of uptake was noted for different tumor grades. The images performed 24 hours after injection did not detect new lesions, but areas of doubtful uptake were seen as positive focal areas in the delayed scan. In these preliminary results the LL2-Fab` MAb seems to be useful for detection, staging and follow up of NHL patients.

  4. Seismic Hazard Maps for the Maltese Archipelago: Preliminary Results

    NASA Astrophysics Data System (ADS)

    D'Amico, S.; Panzera, F.; Galea, P. M.

    2013-12-01

    The Maltese islands form an archipelago of three major islands lying in the Sicily channel at about 140 km south of Sicily and 300 km north of Libya. So far very few investigations have been carried out on seismicity around the Maltese islands and no maps of seismic hazard for the archipelago are available. Assessing the seismic hazard for the region is currently of prime interest for the near-future development of industrial and touristic facilities as well as for urban expansion. A culture of seismic risk awareness has never really been developed in the country, and the public perception is that the islands are relatively safe, and that any earthquake phenomena are mild and infrequent. However, the Archipelago has been struck by several moderate/large events. Although recent constructions of a certain structural and strategic importance have been built according to high engineering standards, the same probably cannot be said for all residential buildings, many higher than 3 storeys, which have mushroomed rapidly in recent years. Such buildings are mostly of unreinforced masonry, with heavy concrete floor slabs, which are known to be highly vulnerable to even moderate ground shaking. We can surely state that in this context planning and design should be based on available national hazard maps. Unfortunately, these kinds of maps are not available for the Maltese islands. In this paper we attempt to compute a first and preliminary probabilistic seismic hazard assessment of the Maltese islands in terms of Peak Ground Acceleration (PGA) and Spectral Acceleration (SA) at different periods. Seismic hazard has been computed using the Esteva-Cornell (1968) approach which is the most widely utilized probabilistic method. It is a zone-dependent approach: seismotectonic and geological data are used coupled with earthquake catalogues to identify seismogenic zones within which earthquakes occur at certain rates. Therefore the earthquake catalogues can be reduced to the

  5. True and false autobiographical memories in schizophrenia: preliminary results of a diary study.

    PubMed

    Pernot-Marino, Elodie; Schuster, Caroline; Hedelin, Guy; Berna, Fabrice; Zimmermann, Marie-Agathe; Danion, Jean-Marie

    2010-08-30

    The frequency of true and false autobiographical memories and associated states of conscious awareness, i.e., conscious recollection and simply knowing, as well as the respective roles of affective and cognitive processes in autobiographical memory construction, were assessed in eight patients with schizophrenia and eight control participants. A diary study methodology was used in combination with the Remember/Know procedure. The results showed a higher frequency of Know responses associated with the retrieval of both true and false memories in patients than in control participants. Whereas control participants rated higher at retrieval than at encoding the distinctiveness and personal importance of events, as well as the extent to which events furthered current personal plans, patients exhibited an opposite pattern of ratings, with ratings being lower at retrieval than at encoding. These preliminary results show a high frequency of simply knowing associated with the retrieval of true and false autobiographical memories in patients with schizophrenia and provide evidence for the interest of the diary study methodology for studying autobiographical memory in schizophrenia. PMID:20478623

  6. Cassini Observations of Saturn's Magnetotail Region: Preliminary Results

    NASA Technical Reports Server (NTRS)

    Sittler, E. C.; Arridge, C.; Rymer, A.; Coates, A.; Krupp, N.; Blanc, M.; Richardson, J.; Andre, N.; Thomsen, M.; Tokar, R. L.; McAndrews, H. J.; Henderson, Mike; Cooper, J. F.; Burger, M.; Simpson, D.; Khurana, K. K.; Russell, C.; Dougherty, M.; Young, D. T.

    2007-01-01

    Using Cassini thermal plasma, hot plasma and magnetic field observations for several intervals between the dawn meridian of Saturn's outer magnetosphere and Saturn's magnetotail region, we investigate the structure of the magnetotail, plasma and magnetic field properties within tail-like current sheet regions and ion flows within the magnetotail regions. We use Cassini Plasma Spectrometer (CAPS) Ion Mass Spectrometer (IMS), Electron Plasma Spectrometer (ELS) observations, MIMI LEMMS ion and electron observations and Cassini magnetometer data (MAG) to characterize the plasma environment. IMS observations are used to measure plasma flow velocities from which one can infer rotation versus convective flows. IMS composition measurements are used to trace the source of plasma from the inner magnetosphere (protons, H2+ and water group ions) versus an external solar wind source (protons and e +i+on s). A critical parameter for both models is the strength of the convection electric field with respect to the rotational electric field for the large scale magnetosphere. For example, are there significant return flows (i.e., negative radial velocities, VR < 0) and/or plasmoids (V(sub R) > 0) within the magnetotail region? Initial preliminary evidence of such out flows and return flows was presented by Sittler et al. This talk complements the more global analysis by McAndrews et al.

  7. Annoyance Caused by Propeller Airplane Flyover Noise: Preliminary Results

    NASA Technical Reports Server (NTRS)

    Mccurdy, D. A.; Powell, C. A.

    1981-01-01

    The annoyance response of people to the noise of propeller airplane flyovers was examined. The specific items of interest were: (1) the annoyance prediction ability of current noise metrics; (2) the effect of tone corrections on prediction ability; (3) the effect of duration corrections on prediction ability; and (4) the effect of 'critical band' corrections on the prediction ability of perceived noise level. Preliminary analyses of the data obtained from two experiments are presented. The first experiment examined 11 propeller airplanes with maximum takeoff weights greater than or equal to 5700 kg. The second experiment examined 14 propeller airplanes weighting 5700 kg or less. Also included in each experiment were five different commercial service jet airplanes. Each airplane noise was presented at D-weighted sound pressure levels of 70, 80, and 90 dB to subjects in a testing room which simulates the outdoor acoustic environment. Subjects judged 108 stimuli in the first experiment and 132 stimuli in the second experiment. Perceived noise level predicted annoyance better than A, D, or E-weighted sound pressure level. Corrections for tones greater than of equal to 500 Hz generally improved prediction ability for the heavier propeller airplanes.

  8. Genesis Silicon Carbide Concentrator Target 60003 Preliminary Ellipsometry Mapping Results

    NASA Technical Reports Server (NTRS)

    Calaway, M. J.; Rodriquez, M. C.; Stansbery, E. K.

    2007-01-01

    The Genesis concentrator was custom designed to focus solar wind ions primarily for terrestrial isotopic analysis of O-17/O-16 and O-18/O-16 to +/-1%, N-15/N-14 to +/-1%, and secondarily to conduct elemental and isotopic analysis of Li, Be, and B. The circular 6.2 cm diameter concentrator target holder was comprised of four quadrants of highly pure semiconductor materials that included one amorphous diamond-like carbon, one C-13 diamond, and two silicon carbide (SiC). The amorphous diamond-like carbon quadrant was fractured upon impact at Utah Test and Training Range (UTTR), but the remaining three quadrants survived fully intact and all four quadrants hold an important collection of solar wind. The quadrants were removed from the target holder at NASA Johnso n Space Center Genesis Curation Laboratory in April 2005, and have been housed in stainless steel containers under continual nitrogen purge since time of disintegration. In preparation for allocation of a silicon carbide target for oxygen isotope analyses at UCLA, the two SiC targets were photographed for preliminary inspection of macro particle contamination from the hard non-nominal landing as well as characterized by spectroscopic ellipsometry to evaluate thin film contamination. This report is focused on Genesis SiC target sample number 60003.

  9. Smokers’ Expectancies for Abstinence: Preliminary Results from Focus Groups

    PubMed Central

    Hendricks, Peter S.; Wood, Sabrina B.; Hall, Sharon M.

    2010-01-01

    Smokers’ expectancies regarding the effects of cigarette use are powerful predictors of smoking motivation and behavior. However, studies have not investigated the consequences that smokers expect when they attempt to quit smoking: abstinence-related expectancies. The primary goal of this qualitative study was to gain initial insight into smokers’ expectancies for abstinence. Eight focus groups were conducted with 30 smokers diverse with respect to age, gender, and ethnoracial background. Content analyses indicated that smokers anticipate a variety of outcomes from abstinence. The most frequently reported expectancies included pharmacologic withdrawal symptoms, behavioral withdrawal symptoms, decreased monetary expense, and immediate improvement of certain aspects of physical functioning and health. Additional expectancies concerned weight gain, improved attractiveness, enhanced social functioning/self-esteem, long-term health outcomes, and loss of relationships. Finally, a number of relatively unheralded expectancies were revealed. These involved NRT effectiveness, alcohol and other drug use, vigilance to cue reactivity, cessation-related social support, aversion to smoking, and “political process” implications. This study provides a preliminary step in understanding smokers’ expectancies for abstinence from cigarettes. PMID:19586157

  10. Preliminary results of a computerized Placido disk surgical corneal topographer

    NASA Astrophysics Data System (ADS)

    Carvalho, Luis A.; Tonissi, S. A.; Castro, Jarbas C.

    1999-06-01

    We have developed a novel instrument for computerized corneal topography during surgery. The instrument measures a region of approximately 7 mm in diameter, providing the surgeon with precise values of power and astigmatism. The system is based on a Placido Disc projecting system, which is attached to the objective lens of the surgical microscope. The Placido Disc pattern is reflected by a 50% beam splitter attached to the body of the microscope. At the beam splitter we installed our home-made adaptor and a CCD monochromatic high resolution camera. A high quality frame grabber is installed on a PC and images are digitized at a 480x640 resolution. Algorithms based on image processing techniques were implemented for edge detection of pattern. Calibrating curves based on 4 spherical surfaces were generated and approximately 3600 points were calculated for each exam. Preliminary measurements on 10 healthy corneas were compared with the measurements made on an EyeSys Corneal Topographer. Mean deviation was 0.05 for radius of curvature, 0.24 D for power and 5 degrees for cylinder. This system, with some improvements, may be successfully used to diminish high post surgical astigmatisms in surgeries such as cataract and corneal transplant. This system could also be used to gather preoperative data in corneal topography assisted LASIK.

  11. WISE/NEOWISE OBSERVATIONS OF THE HILDA POPULATION: PRELIMINARY RESULTS

    SciTech Connect

    Grav, T.; Mainzer, A. K.; Bauer, J.; Masiero, J.; Eisenhardt, P. R.; Blauvelt, E.; DeBaun, E.; Elsbury, D.; Gautier, T.; Gomillion, S.; Hand, E.; Wilkins, A.; Spahr, T.; McMillan, R. S.; Walker, R.; Cutri, R.; Wright, E.

    2012-01-10

    We present the preliminary analysis of 1023 known asteroids in the Hilda region of the solar system observed by the NEOWISE component of the Wide-field Infrared Survey Explorer (WISE). The sizes of the Hildas observed range from {approx}3 to 200 km. We find no size-albedo dependency as reported by other projects. The albedos of our sample are low, with a weighted mean value of p{sub V} = 0.055 {+-} 0.018, for all sizes sampled by the NEOWISE survey. We observed a significant fraction of the objects in the two known collisional families in the Hilda population. It is found that the Hilda collisional family is brighter, with a weighted mean albedo of p{sub V} = 0.061 {+-} 0.011, than the general population and dominated by D-type asteroids, while the Schubart collisional family is darker, with a weighted mean albedo of p{sub V} = 0.039 {+-} 0.013. Using the reflected sunlight in the two shortest WISE bandpasses, we are able to derive a method for taxonomic classification of {approx}10% of the Hildas detected in the NEOWISE survey. For the Hildas with diameter larger than 30 km, there are 67{sup +7}{sub -15}% D-type asteroids and 26{sup +17}{sub -5%} C-/P-type asteroids (with the majority of these being P-types).

  12. Prophylactic volume expansion therapy for the prevention of delayed cerebral ischemia after early aneurysm surgery. Results of a preliminary trial.

    PubMed

    Solomon, R A; Fink, M E; Lennihan, L

    1988-03-01

    From June 1986 to June 1987, 47 consecutive patients with ruptured intracranial aneurysms were treated with immediate aneurysm surgery and prophylactic volume expansion therapy for ten to 14 days after subarachnoid hemorrhage (SAH). Twenty-four patients were admitted within three days of SAH. Twenty-three of these patients had an excellent result, and one patient died. There were no cases of delayed cerebral infarction. In 18 of 23 patients admitted more than three days after SAH, there was an excellent result. The other five patients had permanent morbidity related to the original SAH. These preliminary data suggest that immediate aneurysm surgery and aggressive postoperative prophylactic volume expansion in all patients can substantially reduce rebleeding and delayed cerebral ischemia, potential causes of morbidity, after aneurysmal subarachnoid hemorrhage. A more extensive prospective trial of this approach will be required to test this hypothesis. PMID:3277601

  13. Preliminary results of proton-beam therapy for stage III non-small-cell lung cancer

    PubMed Central

    Hatayama, Y.; Nakamura, T.; Suzuki, M.; Azami, Y.; Ono, T.; Yamaguchi, H.; Hayashi, Y.; Tsukiyama, I.; Hareyama, M.; Kikuchi, Y.; Takai, Y.

    2015-01-01

    Background We conducted a preliminary retrospective evaluation of the efficacy and toxicity of proton-beam therapy (pbt) for stage iii non-small-cell lung cancer. Methods Between January 2009 and August 2013, 27 patients (26 men, 1 woman) with stage iii non-small-cell lung cancer underwent pbt. The relative biologic effectiveness value of the proton beam was defined as 1.1. The beam energy and spread-out Bragg peak were fine-tuned such that the 90% isodose volume of the prescribed dose encompassed the planning target volume. Of the 27 patients, 11 underwent neoadjuvant chemotherapy. Cumulative survival curves were calculated using the Kaplan–Meier method. Treatment toxicities were evaluated using version 4 of the Common Terminology Criteria for Adverse Events. Results Median age of the patients was 72 years (range: 57–91 years), and median follow-up was 15.4 months (range: 7.8–36.9 months). Clinical stage was iiia in 14 patients (52%) and iiib in 13 (48%). The median dose of pbt was 77 GyE (range: 66–86.4 GyE). The overall survival rate in the cohort was 92.3% at 1 year and 51.1% at 2 years. Locoregional failure occurred in 7 patients, and distant metastasis, in 10. In 2 patients, initial failure was both locoregional and distant. The 1-year and 2-year rates of local control were 68.1% and 36.4% respectively. The 1-year and 2-year rates of progression-free survival were 39.9% and 21.4% respectively. Two patients experienced grade 3 pneumonitis. Conclusions For patients with stage iii non-small-cell lung cancer, pbt can be an effective and safe treatment option. PMID:26628878

  14. Comparison of stroke infarction between CT perfusion and diffusion weighted imaging: preliminary results

    NASA Astrophysics Data System (ADS)

    Abd. Rahni, Ashrani Aizzuddin; Arka, Israna Hossain; Chellappan, Kalaivani; Mukari, Shahizon Azura; Law, Zhe Kang; Sahathevan, Ramesh

    2016-03-01

    In this paper we present preliminary results of comparison of automatic segmentations of the infarct core, between that obtained from CT perfusion (based on time to peak parameter) and diffusion weighted imaging (DWI). For each patient, the two imaging volumes were automatically co-registered to a common frame of reference based on an acquired CT angiography image. The accuracy of image registration is measured by the overlap of the segmented brain from both images (CT perfusion and DWI), measured within their common field of view. Due to the limitations of the study, DWI was acquired as a follow up scan up to a week after initial CT based imaging. However, we found significant overlap of the segmented brain (Jaccard indices of approximately 0.8) and the percentage of infarcted brain tissue from the two modalities were still fairly highly correlated (correlation coefficient of approximately 0.9). The results are promising with more data needed in future for clinical inference.

  15. 78 FR 48147 - Polyethylene Terephthalate Film, Sheet, and Strip From India: Preliminary Results of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-07

    ... International Trade Administration Polyethylene Terephthalate Film, Sheet, and Strip From India: Preliminary... film, sheet and strip (PET film) from India for the period of review (POR) January 1, 2011, through... Strip from India (Preliminary Decision Memorandum), dated concurrently with these results and...

  16. 78 FR 15699 - Certain Frozen Warmwater Shrimp From the Socialist Republic of Vietnam: Preliminary Results of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-12

    ... Decision, 76 FR 23277 (April 26, 2011), remains dispositive. \\5\\ See Preliminary Decision Memorandum for a... Orders, 77 FR 29875 (May 21, 2012). Reference to 19 CFR 351.222(b) thus refers to the Department's... Warmwater Shrimp From the Socialist Republic of Vietnam: Preliminary Results of Administrative Review, 77...

  17. [Cardiac transplantation in the infant and young child. Preliminary results].

    PubMed

    Le Bidois, J; Vouhé, P; Kachaner, J; Neveux, J Y; Sidi, D; Touati, G; Sluysmans, T; Guarnera, S; Gay, F; Villain, E

    1988-05-01

    Between January and December, 1987, a programme of heart transplantation in paediatrics was designed and carried out in 9 children by the medical and surgical teams of the Necker/Enfants Malades-Laënnec hospitals group, Paris. Six of the patients were infants of less than 2 years (4 were under one year), and the oldest child was 10 years old. All patients seemed to be condemned to an early death either because their congenital heart disease was beyond the resources of conventional surgery (6 cases) or because their dilated cardiomyopathy was refractory to all medical treatments. Three children died at the end of the operation or a few days afterwards, due to poor quality graft (1 case), fulminating bacterial superinfection (1 case) or intractable pulmonary hypertension (1 case). The remaining 6 children are now living as normally as possible in their respective families. The long-term immunosuppressive treatment consists of cyclosporine and azathrioprine; corticosteroids are only used at the very beginning of treatment or in case of graft rejection. Only two episodes of rejection, confirmed by endomyocardial biopsy, were observed in the same patient during the first postoperative month. Biopsy was never performed systematically in order to spare the patient's vein, and the diagnosis of rejection was suspected on clinical grounds.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:3136723

  18. Preliminary Results on Sediment Sorting Under Intense Bedload Transport

    NASA Astrophysics Data System (ADS)

    Hernandez Moreira, R. R.; Vautin, D.; Mathews, S. L.; Kuprenas, R.; Viparelli, E.

    2014-12-01

    Previous experiments show that parallel-laminated deposits are emplaced under upper plane bed regime by the migration of small-amplitude, long-wavelength bedforms. The present research focuses on how sediment is sorted under upper plane bed and sheet flow transport regimes, and whether parallel-lamination is inhibited during sheet flow transport. The problem of studying the sorting of sediment under so intense transport conditions is plagued by the uncertainties related to flow resistances and bedload transport rates. We simplify the problem by first running the experiments with uniform sediment, to establish a baseline that will aid in the design of the experiments with poorly sorted material. We are running experiments at the Hydraulics Laboratory of the Department of Civil and Environmental Engineering at the University of South Carolina in Columbia, in a unidirectional sediment-feed flume, 9 meters long by 0.2 meters wide, of which 7 meters are used as test section. During the experiments, water surface and bed elevations are periodically measured to characterize the global parameters of the flow, e.g. mean flow velocity and bed shear stress. When the flow and the sediment transport reach conditions of mobile bed equilibrium, bed elevation fluctuations are measured with ultrasonic transducer systems at six fixed locations. Channel bed aggradation is then induced by slowly raising the tail gate of the flume such that there is no change in transport regime, as confirmed by additional measurements of water surface and bed elevation and bed elevation fluctuations. Preliminary observations under upper plane bed regime show the formation of the small-amplitude and long-wavelength bedforms, as well as hints of parallel lamination in the deposits. In the near future we aim to achieve sheet flow transport conditions with both uniform and non-uniform grain size distributions to look at the internal structure of the emplaced deposit.

  19. The extent of vitamin K deficiency in patients with cholestatic jaundice: a preliminary communication.

    PubMed Central

    O'Brien, D P; Shearer, M J; Waldron, R P; Horgan, P G; Given, H F

    1994-01-01

    Eleven patients with cholestatic jaundice had measurements of plasma vitamin K1 performed. Seven of these 11 (64%) had subnormal levels. The prothrombin time (PT) was prolonged in three of 15 patients with cholestasis (20%), the patient with the longest PT had the lowest vitamin K1 level. A single intramuscular (im) dose of 10 mg vitamin K1 lowered the PT in 9/15 patients (includes correcting the three prolonged PTs). The initial mean plasma vitamin K1 level rose 24 h later, to a mean plasma level which was 33 times the upper limit of the normal physiological range. These preliminary results suggest that a majority of patients presenting with cholestatic jaundice have low tissue reserves of vitamin K1, and that guidelines for vitamin K1 therapy in patients with cholestatic jaundice should be revised. PMID:8046700

  20. Mobile biofeedback of heart rate variability in patients with diabetic polyneuropathy: a preliminary study.

    PubMed

    Druschky, Katrin; Druschky, Achim

    2015-09-01

    Biofeedback of heart rate variability (HRV) was applied to patients with diabetic polyneuropathy using a new mobile device allowing regularly scheduled self-measurements without the need of visits to a special autonomic laboratory. Prolonged generation of data over an eight-week period facilitated more precise investigation of cardiac autonomic function and assessment of positive and negative trends of HRV parameters over time. Statistical regression analyses revealed significant trends in 11 of 17 patients, while no significant differences were observed when comparing autonomic screening by short-term HRV and respiratory sinus arrhythmia at baseline and after the 8 weeks training period. Four patients showed positive trends of HRV parameters despite the expected progression of cardiac autonomic dysfunction over time. Patient compliance was above 50% in all but two patients. The results of this preliminary study indicate a good practicality of the handheld device and suggest a potential positive effect on cardiac autonomic neuropathy in patients with type 2 diabetes. PMID:24438496

  1. Evaluating outcomes of palliative photodynamic therapy: instrument development and preliminary results

    NASA Astrophysics Data System (ADS)

    Goodell, Teresa T.; Bargo, Paulo R.; Jacques, Steven L.

    2002-06-01

    Background: Subjective measures are considered the gold standard in palliative care evaluation, but no studies have evaluated palliative photodynamic therapy (PDT) subjectively. If PDT is to be accepted as a palliative therapy for later-stage obstructing esophageal and lung cancer, evidence of its effectiveness and acceptability to patients must be made known. Study Design/Materials and Methods: This ongoing study's major aim is to evaluate subjective outcomes of PDT in patients with obstructing esophageal and lung cancer. Existing measures of health status, dysphagia and performance status were supplemented with an instrument developed to evaluate PDT symptom relief and side effect burden, the PDT Side Effects Survey (PSES). Results: PDT patients treated with porfimer sodium (Photofrin) and 630-nm light experienced reduced dysphagia grade and stable performance status for at least one month after PDT (N= 10-17), but these effects did not necessarily persist at three months. Fatigue, appetite and quality of life may be the most burdensome issues for these patients. Conclusions: Preliminary data suggest that the PSES is an acceptable and valid tool for measuring subjective outcomes of palliative PDT. This study is the first attempt to systematically evaluate subjective outcomes of palliative PDT. Multi-center outcomes research is needed to draw generalizable conclusions that will establish PDT's effectiveness in actual clinical practice and enhance the wider adoption of PDT as a cancer symptom relief modality.

  2. Radiologically Defined Ecological Dynamics and Clinical Outcomes in Glioblastoma Multiforme: Preliminary Results1

    PubMed Central

    Zhou, Mu; Hall, Lawrence; Goldgof, Dmitry; Russo, Robin; Balagurunathan, Yoganand; Gillies, Robert; Gatenby, Robert

    2014-01-01

    MATERIALS AND METHODS: We examined pretreatment magnetic resonance imaging (MRI) examinations from 32 patients with glioblastoma multiforme (GBM) enrolled in The Cancer Genome Atlas (TCGA). Spatial variations in T1 post-gadolinium and either T2-weighted or fluid attenuated inversion recovery sequences from each tumor MRI study were used to characterize each small region of the tumor by its local contrast enhancement and edema/cellularity (“habitat”). The patient cohort was divided into group 1 (survival < 400 days, n = 16) and group 2 (survival > 400 days, n = 16). RESULTS: Histograms of relative values in each sequence demonstrated that the tumor regions were consistently divided into high and low blood contrast enhancement, each of which could be subdivided into regions of high, low, and intermediate cell density/interstitial edema. Group 1 tumors contained greater volumes of habitats with low contrast enhancement but intermediate and high cell density (not fully necrotic) than group 2. Both leave-one-out and 10-fold cross-validation schemes demonstrated that individual patients could be correctly assigned to the short or long survival group with 81.25% accuracy. CONCLUSION: We demonstrate that novel image analytic techniques can characterize regional habitat variations in GBMs using combinations of MRI sequences. A preliminary study of 32 patients from the TCGA database found that the distribution of MRI-defined habitats varied significantly among the different survival groups. Radiologically defined ecological tumor analysis may provide valuable prognostic and predictive biomarkers in GBM and other tumors. PMID:24772202

  3. Preliminary Results From the C-Pulse® OPTIONS HF European Multicenter Post-Market Study

    PubMed Central

    Schulz, Antonia; Krabatsch, Thomas; Schmitto, Jan D.; Hetzer, Roland; Seidel, Mirko; Dohmen, Pascal M.; Hotz, Holger

    2016-01-01

    Background The C-Pulse® System is an extra-aortic balloon counterpulsation device. It is used to treat patients with heart failure disease in NYHA functional class III or ambulatory class IV. Material/Methods We present preliminary site-reported 6-month data from 3 centers in Germany as part of the prospective observational post-market OPTIONS HF study. Results Between May 2013 and March 2014, the C-Pulse System was implanted in 8 patients (7 male) with a mean age of 61.6±9.3 years. Four had ischemic and 4 had non-ischemic cardiomyopathy. No stroke, myocardial infarction, major bleeding, or major infection due to the device were reported. One patient developed non-device-related refractory tachycardia with worsening heart failure 12 h after surgery and underwent left ventricular assist device implantation. Within 6 months of observation, functional status improved from NYHA III to II in 5 patients, and 2 remained in NYHA III. Mean left ventricular ejection fraction increased from 24.3±7.9% to 44.5±4.5% (p<0.0001). Mean Kansas City Cardiomyopathy Questionnaire overall score improved from 28.6±19.1 to 59.1±22.5 (p=0.0183). Six-minute walk test was performed in 6 out of 7 patients at follow-up. The mean distance improved from 252.0±85.1 m to 279.2±87.5 m (p>0.05). One patient was weaned off the device after 6 months of support. Conclusions The C-Pulse System provides a therapeutic option for patients with moderate-to-severe heart failure and seems to improve quality of life and cardiac function over time. PMID:26887528

  4. Intraarterial combined immunochemotherapy for unresectable hepatocellular carcinoma: preliminary results.

    PubMed

    Oka, M; Hazama, S; Yoshino, S; Shimoda, K; Suzuki, M; Shimizu, R; Yano, K; Nishida, M; Suzuki, T

    1994-03-01

    An important objective for patients with unresectable hepatocellular carcinoma (HCC) is the development of effective chemotherapy. We administered a combination of biological response modifiers and anticancer agents to 24 patients with unresectable HCC. Each case had an implanted infuser port which was connected to a catheter placed in the hepatic artery for the intraarterial (i.a.) administration of chemotherapy. The following agents were administered to each patient: recombinant interleukin-2 (800,000 JRU/day infused i.a. continuously for 6 days/week); OK-432 (5 KE injected i.a. twice in 4 weeks and i.m. three times per week); Adriamycin (10 mg injected i.a. twice in 4 weeks); cyclophosphamide (300 mg injected i.a. twice in 4 weeks), and famotidine (40 mg/day administered orally). Objective response was assessed according to tumor size measured by computed tomography and angiography before and after treatment. We observed a complete response (CR) in 4, partial response (PR) in 3, minor response (MR) in 7, no change (NC) in 7, and progressive disease (PD) in 3. The response rate (CR+PR+MR) was 58.3%. The overall 2-year survival rate was 52%. The 2-year survival rate of the responders (CR+PR+MR) was 80%, while that of the non-responders (NC+PD) was 0%. There was a significant difference between the responders and non-responders in respect to survival rate (P < 0.05). The percentages of CD25+ cells, CD56+ cells, and Leu7-CD16+ cells and NK activity in the peripheral blood showed a significant increase following the regimen. Serum levels of tumor necrosis factor alpha TNF alpha rose after the initiation of OK-432. TNF alpha levels were higher in the responders than in the non-responders. Adverse effects included high fever (all patients) and severe transient hypotension (15 patients) that was controlled by conservative therapy. Combined immunochemotherapy administered intraarterially may be a new strategy for treating unresectable HCC. PMID:8124688

  5. Microbial extremophiles from the 2008 Schirmacher Oasis Expedition: preliminary results

    NASA Astrophysics Data System (ADS)

    Hoover, Richard B.; Pikuta, Elena V.; Townsend, Alisa; Anthony, Joshua; Guisler, Melissa; McDaniel, Jasmine; Bej, Asim; Storrie-Lombardi, Michael

    2008-08-01

    Among the most interesting targets for Astrobiology research are the polar ice caps and the permafrost of Mars and the ice and liquid water bodies that may lie beneath the frozen crusts of comets, the icy moons of Jupiter (Europa, Io and Ganymede) and Saturn (Titan and Enceladus). The permanently ice-covered lakes of Antarctica, such as Lake Vostok and Lake Untersee, provide some of the best terrestrial analogues for these targets. The 2008 International Tawani Schirmacher Oasis/Lake Untersee Expeditions have been organized to conduct studies of novel microbial extremophiles and investigate the biodiversity of the glaciers and ice-covered lakes of Dronning Maud Land, East Antarctica. This paper describes the preliminary analysis of the anaerobic microbial extremophiles isolated from samples collected during the 2008 International Schirmacher Oasis Antarctica Reconnaissance Expedition. These samples showed great diversity of psychrophlic and psychrotolerant bacteria. Six new anaerobic strains have been isolated in pure cultures and partially characterized. Two of them (strains ARHSd-7G and ARHSd-9G) were isolated from a small tidal pool near the colony of African Penguins Spheniscus demersus. Strain ARHSd-7G was isolated on mineral anaerobic medium with 3 % NaCl, pH 7 and D-glucose, it has motile, vibrion shape cells, and is Gram variable. Strain ARHSd-9G grew on anaerobic, alkaline medium with pH 9 and 1 % NaCl at 3°C. The substrate was D-glucose supplemented with yeast extract (0.05 %). Cells of strain ARHSd-9G had morphology of straight or slightly curved elongated rods and demonstrated unusual optical effects under dark-field visible light microscopy. The cells were spore-forming and Gram positive. From the mat sample collected near Lake Zub, the new strain LZ-3 was isolated in pure culture at 3°C. Strain LZ-3 was anaerobic and grew on 0.5 % NaCl mineral medium with Dglucose as a substrate. The gram positive cells were spore-forming. They exhibited a

  6. Preliminary results of the ground geophysical monitoring in Gschliefgraben

    NASA Astrophysics Data System (ADS)

    Jochum, Birgit; Lovisolo, Mario; Supper, Robert; Ita, Anna; Baron, Ivo; Ottowitz, David

    2010-05-01

    In September 2009, a fully automatic multiparametric in place column D.M.S. IUT, (68 sensors, active monitoring depth = 33 m) designed and manufactured by the Italian company C.S.G. S.r.l., was installed in an inclinometric borehole by helicopter at Gschliefgraben landslide. The landslide is affecting houses and a road at the eastern rim of the Traunsee and caused considerable damage in 2007/2008. The survey area is located at the border of the Flysch Zone and the Northern Limestone Alps, which is known to be prone to landslide activity. Extensive drainaging reduces the amount of precipitation seeping into the ground. Thus, the displacement monitored in real time by DMS at the present time seems to be not strickly dependent of rainfall. The preliminary data show a main sliding zone occurring at 10-12 m bgl. The mean velocity was 10 mm/month in the interval time 24 September - 24 November, then the time history shows an increase up to 15 mm/month until the end of December. In the first days of January 2010 the velocity trend is reducing to 2 mm/week. An extensive geolectrical survey has been performed before to interpret the subsurface structure regarding possible depths and spatial delimitation of the sliding zone and to find the best position of the monitoring system. In the vicinity of the inclinometer a geoelectric monitoring system (GeoMonitor4D, developed by the Geological Survey of Austria) was installed to correlate measured resistivity values with displacement rates. It consists of 2 profiles, with a length of 120m and 192m. Both systems send their data once a day automatically by UMTS to the data centers in Ricaldone (Italy) and Vienna (Austria). In spring 2010 a second DMS column will be placed at the foot of the hill. The integrated analysis of the airborne and ground measurements, carried out by the Geological Survey of Austria combined with several other parameters, provided by the Torrent and Avalanche Control, will contribute to understand the

  7. Coastal Transport Integrated System in the Aegean Sea Islands: Framework, Methodology, Data Issues and Preliminary Results

    NASA Astrophysics Data System (ADS)

    Pantazis, D. N.; Stratakis, P.; Karathanasis, C.; Gkadolou, E.; Pagounis, V.; Chronis, K.; Gatsiou, M.; Moumouri-Frag, F.; Tsekos, P.

    2013-05-01

    Greece has more than one hundred inhabited islands, the majority of them are geographically scattered in small distances in the Aegean Sea. The Aegean Sea suffers systematically from two major issues. First, many islands are not served quite frequently with the continent or other islands' major ports. It is a situation rather problematic for the habitants of the islands who wish to travel, for the patients in need to be transferred to metropolitan hospitals, for the goods transport from and to islands. Second, there is a crucial issue in the Aegean Sea regarding the so-called "thin lines". Governments spend every year tens of million euros in subsidies in order to sustain the thin lines. Our aim is the development of an integrated and holistic spatial information system to effectively design coastal transportation lines to combat the above mentioned problems. This paper will present the project framework, the methodology followed, data issues and preliminary results.

  8. Clinicopathological characteristics of infiltrating lobular breast carcinoma in elderly women: Preliminary results

    PubMed Central

    RUIBAL, ALVARO; AGUIAR, PABLO; DEL CAMEN DEL RÍO, MARIA; MENÉNDEZ, PRIMITIVA; ARIAS, JOSÉ IGNACIO; HERRANZ, MICHEL

    2015-01-01

    This study was conducted to investigate the clinicopathological parameters in elderly women (aged >70 years) with infiltrating lobular carcinoma (ILC) of the breast and compare the results with those obtained from younger patients (aged 55–70 years). The study sample included a total of 46 women with ILCs, 10 aged >70 and 36 aged 55–70 years. The parameters analysed were tumor size, histological grade (HG), axillary lymph node involvement, distant metastasis and immunohistochemical expression of estrogen, progesterone and androgen receptors, Ki67, p53 and B cell lymphoma 2. Compared to women aged 55–70 years, ILCs in women aged >70 years were commonly of larger size (P=0.068) and were more frequently HG3 (P=0.024). There were no statistically significant differences in the other parameters analysed. Furthermore, we were unable to determine differences in cancer recurrence and mortality in the two patient subgroups during our follow-up. In conclusion, our preliminary results, based on the limited number of cases included in this study, indicate that i) ILCs in women aged >70 years tended to be larger compared to those in women aged 55–70 years and were more frequently of grade 3; and ii) there were no significant differences in terms of recurrence and mortality between the two patient subgroups during our follow-up. PMID:26807244

  9. Target error for image-to-physical space registration: preliminary clinical results using laser range scanning

    NASA Astrophysics Data System (ADS)

    Cao, Aize; Miga, Michael I.; Dumpuri, P.; Ding, S.; Dawant, B. M.; Thompson, R. C.

    2007-03-01

    In this paper, preliminary results from an image-to-physical space registration platform are presented. The current platform employs traditional and novel methods of registration which use a variety of data sources to include: traditional synthetic skin-fiducial point-based registration, surface registration based on facial contours, brain feature point-based registration, brain vessel-to-vessel registration, and a more comprehensive cortical surface registration method that utilizes both geometric and intensity information from both the image volume and physical patient. The intraoperative face and cortical surfaces were digitized using a laser range scanner (LRS) capable of producing highly resolved textured point clouds. In two in vivo cases, a series of registrations were performed using these techniques and compared within the context of a true target error. One of the advantages of using a textured point cloud data stream is that true targets among the physical cortical surface and the preoperative image volume can be identified and used to assess image-to-physical registration methods. The results suggest that iterative closest point (ICP) method for intraoperative face surface registration is equivalent to point-based registration (PBR) method of skin fiducial markers. With regard to the initial image and physical space registration, for patient 1, mean target registration error (TRE) were 3.1+/-0.4 mm and 3.6 +/-0.9 mm for face ICP and skin fiducial PBR, respectively. For patient 2, the mean TRE were 5.7 +/-1.3 mm, and 6.6 +/-0.9 mm for face ICP and skin fiducial PBR, respectively. With regard to intraoperative cortical surface registration, SurfaceMI outperformed feature based PBR and vessel ICP with 1.7+/-1.8 mm for patient 1. For patient 2, the best result was achieved by using vessel ICP with 1.9+/-0.5 mm.

  10. The Mount Logan (Yukon) Ice Cores: Preliminary Results

    NASA Astrophysics Data System (ADS)

    Fisher, D. A.

    2004-05-01

    Bourgeois, Mike Demuth, David Fisher, Roy Koerner,Chris Zdanowicz, James Zheng. University of Ottawa: Ian Clarke,Raphaelle Cardyn. National Institute of Polar Research (Japan): Kumiko Goto-Azuma University of New Hampshire: Cam Wake, Kaplan Yalcin. University of Maine: Karl Kreutz, Paul Mayewski, Erich Osterberg. Arctic Institute of North America: Gerald Holdsworth. University of Washington: Eric J. Steig, Summer B. Rupper. University of Copenhagen: Dorthe Dahl-Jensen. David Fisher is the presenter but many contributed to what is a joint preliminary offering.