Sample records for pectus excavatum tratamiento

  1. Pectus excavatum: history, hypotheses and treatment options

    PubMed Central

    Brochhausen, Christoph; Turial, Salmai; Müller, Felix K.P.; Schmitt, Volker H.; Coerdt, Wiltrud; Wihlm, Jean-Marie; Schier, Felix; Kirkpatrick, C. James

    2012-01-01

    Pectus excavatum and pectus carinatum represent the most frequent chest wall deformations. However, the pathogenesis is still poorly understood and research results remain inconsistent. To focus on the recent state of knowledge, we summarize and critically discuss the pathological concepts based on the history of these entities, beginning with the first description in the sixteenth century. Based on the early clinical descriptions, we review and discuss the different pathogenetic hypotheses. To open new perspectives for the potential pathomechanisms, the embryonic and foetal development of the ribs and the sternum is highlighted following the understanding that the origin of these deformities is given by the disruption in the maturation of the parasternal region. In the second, different therapeutical techniques are highlighted and based on the pathogenetic hypotheses and the embryological knowledge potential new biomaterial-based perspectives with interesting insights for tissue engineering-based treatment options are presented. PMID:22394989

  2. Pectus excavatum: history, hypotheses and treatment options.

    PubMed

    Brochhausen, Christoph; Turial, Salmai; Müller, Felix K P; Schmitt, Volker H; Coerdt, Wiltrud; Wihlm, Jean-Marie; Schier, Felix; Kirkpatrick, C James

    2012-06-01

    Pectus excavatum and pectus carinatum represent the most frequent chest wall deformations. However, the pathogenesis is still poorly understood and research results remain inconsistent. To focus on the recent state of knowledge, we summarize and critically discuss the pathological concepts based on the history of these entities, beginning with the first description in the sixteenth century. Based on the early clinical descriptions, we review and discuss the different pathogenetic hypotheses. To open new perspectives for the potential pathomechanisms, the embryonic and foetal development of the ribs and the sternum is highlighted following the understanding that the origin of these deformities is given by the disruption in the maturation of the parasternal region. In the second, different therapeutical techniques are highlighted and based on the pathogenetic hypotheses and the embryological knowledge potential new biomaterial-based perspectives with interesting insights for tissue engineering-based treatment options are presented. PMID:22394989

  3. Silastic Molding Method for Pectus Excavatum Correction Using a Polyvinyl Alcohol (Ivalon) Sponge

    PubMed Central

    Lee, Jun-Ho; Kim, Sung-Jin; Chung, Won-Sang; Kim, Hyuck; Chon, Soon-Ho

    2012-01-01

    Pectus excavatum is rare, but it is the most common type of sternal congenital disorder. There are many surgical methods to correct pectus excavatum such as the Ravitch method, Wada method, Silastic mold method, and the Nuss operation. We report a case of minimal invasive surgery for pectus excavatum using a polyvinyl alcohol sponge. PMID:23275928

  4. Pectus Excavatum and Heritable Disorders of the Connective Tissue

    PubMed Central

    Tocchioni, Francesca; Ghionzoli, Marco; Messineo, Antonio; Romagnoli, Paolo

    2013-01-01

    Pectus excavatum, the most frequent congenital chest wall deformity, may be rarely observed as a sole deformity or as a sign of an underlying connective tissue disorder. To date, only few studies have described correlations between this deformity and heritable connective tissue disorders such as Marfan, Ehlers-Danlos, Poland, MASS (Mitral valve prolapse, not progressive Aortic enlargement, Skeletal and Skin alterations) phenotype among others. When concurring with connective tissue disorder, cardiopulmonary and vascular involvement may be associated to the thoracic defect. Ruling out the concomitance of pectus excavatum and connective tissue disorders, therefore, may have a direct implication both on surgical outcome and long term prognosis. In this review we focused on biological bases of connective tissue disorders which may be relevant to the pathogenesis of pectus excavatum, portraying surgical and clinical implication of their concurrence. PMID:24198927

  5. Pectus excavatum in blunt chest trauma: a case report

    PubMed Central

    2013-01-01

    Introduction Blunt cardiac rupture is an exceedingly rare injury. Case presentation We report a case of blunt cardiac trauma in a 43-year-old Caucasian German mother with pectus excavatum who presented after a car accident in which she had been sitting in the front seat holding her two-year-old boy in her arms. The mother was awake and alert during the initial two hours after the accident but then proceeded to hemodynamically collapse. The child did not sustain any severe injuries. Intraoperatively, a combined one-cm laceration of the left atrium and right ventricle was found. Conclusion Patients with pectus excavatum have an increased risk for cardiac rupture after blunt chest trauma because of compression between the sternum and spine. Therefore, patients with pectus excavatum and blunt chest trauma should be admitted to a Level I Trauma Center with a high degree of suspicion. PMID:23320897

  6. Minimally invasive repair of pectus excavatum deformity.

    PubMed

    Krasopoulos, George; Goldstraw, Peter

    2011-02-01

    This review is trying to address the effectiveness and sustainability of results following minimally invasive repair of pectus excavatum (MIRPE). The aim is to present these results for the benefit of clinicians and the patients. Literature search has revealed 179 hits, which were independently assessed and led to 80 publications being formally reviewed. Studies reporting results from less than 10 patients were excluded. Thirty-five studies were found to be reporting results from patients' and/or surgeons' perspective and they were included in this review. Data from the United Kingdom registry for MIRPE were also included. Results from over 2997 patients (age: <1-85 years) who had MIRPE and 1393 patients who had their metallic bar removed were assessed. The most common indication for surgery was cosmesis. There was a net gain with regard to self-esteem for 96-100% of the individuals. A percentage of procedures (0-20%) was assessed by surgeons as having an 'unsatisfactory outcome' and a number of patients (0-25%) reported an 'unsatisfactory end result.' However, these percentages are not necessarily referring to the same patients and an unsatisfactory result does not seem to affect the positive effect on self-esteem. The reported changes in social life, lung capacity, cardiovascular capacity, exercise capacity and general health are based on weak data and significant improvements, if any, are probably seen in a limited number of patients. The metallic bars were removed after 1.5-4.5 years and there is an overall 0-4.5% reported recurrence post-bar removal. In conclusion, MIRPE may improve cosmesis and self-esteem of patients with pectus excavatum deformity. Direct or indirect improvement in other physiological parameters may also help the 'well-being' of these patients and their social integration. There is a clear need for standardisation in the way results are reported in the literature and a socioeconomic analysis with regard to gains, benefits and costs related to MIRPE. PMID:20739187

  7. Pectus excavatum, not always as harmless as it seems.

    PubMed

    Winkens, Ron; Guldemond, Frank; Hoppener, Paul; Kragten, Hans; van Leeuwen, Yvonne

    2009-01-01

    Pectus excavatum is usually considered meaningless and without clinical significance. The following case may put a different complexion on the matter. A healthy 59-year-old male patient complained of progressive heart palpitations, fatigue and postural dyspnoea; bending over caused a clear increase of dyspnoea. At repeated examinations no overt abnormality or explanation was found, except a supraventricular arrhythmia and a nodal tachycardia. In the years to follow the symptoms led to considerable physical impairments. Finally, the patient himself, after searching the web, came up with a possible cause: his pectus excavatum. A lateral chest x-ray with the patient bending over and a lateral computed tomography of the thorax revealed an impression of the heart by the sternum. Ten years after the patient's signs and symptoms first appeared, a modified Ravitch procedure was carried out, after which the physical condition of the patient improved rapidly. PMID:22171234

  8. Positional hyperventilation-induced hypoxaemia in pectus excavatum.

    PubMed

    Wallaert, B; Cavestri, B; Fournier, C; Nevière, R; Aguilaniu, B

    2006-07-01

    The presented case is of a young male (aged 19 yrs) with a pectus excavatum who showed significant exercise intolerance, despite normal pulmonary function at rest, including carbon monoxide diffusing capacity. Clinical exercise testing led to a strong suspicion of a right-to-left shunt due to an abnormally wide alveolo-arterial oxygen gradient (26.4 kPa) at peak oxygen uptake, with severe arterial hypoxaemia (arterial oxygen tension 12.54 kPa). A right-to-left shunt was confirmed by transoesophageal echocardiography demonstrating a permeable foramen ovale, despite normal right heart pressures. The right-to-left venous flow was mainly dependent on the upright body position and the deep inspiration. Indeed, i.v. dobutamine infusion to selectively affect cardiac output and hyperventilation induced by tidal volume expansion at constant breathing rate in the supine position did not result in arterial oxygen desaturation or shunting. Closure of the foramen ovale through atrial umbrella placement dramatically improved clinical and physiological abnormalities. This observation demonstrates that a hyperventilatory manoeuvre in the upright position is able to detect a permeable foramen ovale favouring flow in the inferior vena cava in the direction of the abnormal pre-existing atrial channel in a patient with a pectus excavatum. PMID:16816351

  9. Operative correction of pectus excavatum: an evolving perspective.

    PubMed

    Haller, A J; Katlic, M; Shermeta, D W; Shaker, I J; White, J J

    1976-11-01

    From 1949 to 1975, 220 children have undergone surgical reconstruction of pectus excavatum using a variety of operations on our Pediatric Surgical Service. The first 183 were previously reported and have had subsequent, careful followup evaluation. From 1970 to 1975, an identifiable group of 45 children had a standard operation, a modified Ravitch repair, with the addition of a three-point or tripod internal fixation technique for support of the sternum. These children have all obtained satisfactory reconstruction without prosthetic support of any kind. We have thus avoided the possible danger of foreign material within the chest and have obviated the need for another procedure to remove a supporting stent. The two groups have been analyzed and compared with respect to age distribution, postoperative complications and end results to see if we could detect any trends in the evolving management of children with this condition. The main indications for surgical correction remain cosmetic and postural. Specific trends which have emerged from our experience include an increased percentage of patients between 3 and 8 years of age (average 5.8 years); a decreased need for blood transfusion (10%); a near resolution of postoperative seromas with the use of substernal and subcutaneous suction drains; and in the last 45 children, a 100% excellent or acceptable result to date. We feel that age selection is an important factor in the improved operative result and in the emotional impact on these young patients. Eighty per cent of the children in the recent series were between 3 and 8 years of age at the time of repair. On the basis of this experience, we now feel confident in recommending our standardized operation for pectus excavatum at an elective age of 4 to 6 years. PMID:984924

  10. The vacuum bell for treatment of pectus excavatum: an alternative to surgical correction?

    Microsoft Academic Search

    Frank-Martin Haecker; Johannes Mayr

    2006-01-01

    Objective: Pectus excavatum (PE) is the most common chest wall malformation and one of the most frequent major congenital anomalies. The surgical repair of PE in childhood is a well-established procedure. Previously used operative techniques to correct PE were largely based on the Ravitch technique. Today, the minimally invasive repair (MIRPE) by Nuss is well established. Conservative treatment with the

  11. Virtual simulation of the postsurgical cosmetic outcome in patients with Pectus Excavatum

    NASA Astrophysics Data System (ADS)

    Vilaça, João L.; Moreira, António H. J.; L-Rodrigues, Pedro; Rodrigues, Nuno; Fonseca, Jaime C.; Pinho, A. C. M.; Correia-Pinto, Jorge

    2011-03-01

    Pectus excavatum is the most common congenital deformity of the anterior chest wall, in which several ribs and the sternum grow abnormally. Nowadays, the surgical correction is carried out in children and adults through Nuss technic. This technic has been shown to be safe with major drivers as cosmesis and the prevention of psychological problems and social stress. Nowadays, no application is known to predict the cosmetic outcome of the pectus excavatum surgical correction. Such tool could be used to help the surgeon and the patient in the moment of deciding the need for surgery correction. This work is a first step to predict postsurgical outcome in pectus excavatum surgery correction. Facing this goal, it was firstly determined a point cloud of the skin surface along the thoracic wall using Computed Tomography (before surgical correction) and the Polhemus FastSCAN (after the surgical correction). Then, a surface mesh was reconstructed from the two point clouds using a Radial Basis Function algorithm for further affine registration between the meshes. After registration, one studied the surgical correction influence area (SCIA) of the thoracic wall. This SCIA was used to train, test and validate artificial neural networks in order to predict the surgical outcome of pectus excavatum correction and to determine the degree of convergence of SCIA in different patients. Often, ANN did not converge to a satisfactory solution (each patient had its own deformity characteristics), thus invalidating the creation of a mathematical model capable of estimating, with satisfactory results, the postsurgical outcome.

  12. Nuss technique in pectus excavatum: a mono-institutional experience

    PubMed Central

    2015-01-01

    Background Pectus excavatum (PE) is the most common anomaly of the anterior chest wall. Prior PE was corrected by a modified Ravitch operation, but since Nuss published his minimal technique in 1998, most surgeons have preferred this technique. Methods Since 2001 the modified Nuss procedure has routinely been used for correction of more than 1,500 patients at Aarhus University Hospital. In the time period between January 1, 2011 and January 31, 2015, 675 patients have been corrected. The median age was 16 years (range, 11-58 years). All patients had preoperatively an epidural catheter and the operations were done in general anaesthesia. The postoperative pain treatment was planned for 4-5 weeks and the patients were routinely seen in the outpatient clinic 6 weeks after surgery and the bars removed after 3 years. Results Four hundred-and-fifty patients had one bar, 216 patients with two bars and nine patients with three bars inserted. The median length of the bar was 10 inch. The median duration of the operation was 29 minutes. The median postoperative stay was 3 days. No death, cardiac perforation or deep infection occurred and only 5% of the patients experienced a complication. Conclusions The Nuss procedure should still be considered in the treatment of PE. To my opinion, it should be the choice for correction of PE. The short bar should be used to achieve the best stability of the system, to obtain a good cosmetic result, a reduced dysfunction motion of the chest wall and an increased cardiac performance. PMID:25984364

  13. [Cardiopulmonary exercise testing in patients with pectus excavatum].

    PubMed

    Cavestri, B; Wurtz, A; Bart, F; Nevière, R; Aguilaniu, B; Wallaert, B

    2010-09-01

    The functional consequences of physiologic impairments due to pectus excavatum (PE) are not known. This study was conducted to determine the exercise performance in patients with this condition. This prospective study included all patients presenting for PE during a 5-year period. Patients had a chest CT scan to measure the PE severity index, resting pulmonary function tests, cardiopulmonary exercise testing (CPET) with gas exchange analysis and echocardiography. Thirty-two patients were included, with a mean age of 25.9 years. The mean PE severity index was 3.72 ± 0.87. The maximal oxygen uptake (VO(2-max)) was 78.6 ± 22.1% predicted. Only four out of the 32 patients had a normal CPET. In the remaining patients, we observed three main patterns of limitation: 18 patients had a marked limitation in increasing their tidal volume (41 ± 5% of FVC at VO(2-max) versus 51 ± 7.5%); five patients had abnormal gas exchange with increased P(A-a)O(2) at VO(2-max) (47 ± 23 mmHg versus 20 ± 7.5 mmHg) associated with a patent foramen ovale without elevation of right pressure. The five last patients had cardiovascular impairment with a decreased oxygen pulse at VO(2-max) (57 ± 9% versus 90 ± 20%). They exhibited the most severe limitation (VO(2-max) = 55 ± 10%; P = 0.003). CPET abnormalities were predicted by neither PE index severity nor the results of resting pulmonary function tests. PE is associated with abnormal CPET, including impairments in ventilatory, cardiovascular responses and/or gas exchange, which may be of importance in disease management. PMID:20863972

  14. Screening for pectus excavatum among primary students and establishment of a pectus excavatum screening program in Dongguan, China

    PubMed Central

    Zou, Xusen; Lin, Yanqing; Jin, Hui; Cai, Sumei; Xu, Xin; Yin, Weiqiang; Geng, Qingshan; Chen, Jiuhao; Liang, Bing

    2015-01-01

    Objective To carry out pectus excavatum (PEx) screening among primary school students in Dongguan, with an attempt to establish a PEx screening program and provide epidemiological evidences for developing guidelines on the diagnosis and treatment of PEx for young children. Methods A total of 479,402 primary school students who were already in school in 2012 or newly enrolled in 2013 from 422 primary schools in 32 towns in Dongguan, Guangdong Province were screened for PEx. Meanwhile, about 420 medical staff from the infirmaries of 422 primary schools were provided with a serial of training, with an attempt to establish a PEx screening program and network. Results Valid screening results were obtained from 477,627 pupils (99.62%) from 406 primary schools in 31 towns. These students aged 4-15 years (mean: 8.78 years), among whom there were 244,545 males (N1; mean age: 8.22 years) and 233,082 females (N2; mean age: 8.89 years). Totally 257 PEx patients were identified, yielding a prevalence of 0.583%, among whom there were 176 males (N3; mean age: 8.79 years) and 81 females (N4; mean age: 8.77 years). With the PEx patients as the PEx group and the healthy children as the control group, chi square test with gender as the dependent variable showed that the incidence of PEx was significantly different between male and female students (P=0.00) (N3:N4 =2.172:1). In addition, 410 medical staff from the school infirmaries were trained, and a PEx screening program and network was established. Conclusions The screening for PEx was successfully performed among pupils who were already in school in 2012 or newly enrolled in 2013 from 422 primary schools in Dongguan, Guangdong Province. Statistical analysis showed that the incidence of PEx differed between male and female pupils. A stable effective PEx screening program was established, which will provide personal and technical supports for the early diagnosis and treatment of this condition.

  15. Pectus excavatum in relief from Ancient Egypt (dating back to circa 2400 BC).

    PubMed

    Bialas, Adam J; Kaczmarski, Jacek; Kozak, Jozef; Kempinska-Miroslawska, Bogumila

    2015-04-01

    Pectus excavatum is one of the most common congenital deformities of the chest wall. The aim of the study was to analyse 621 artefacts (reliefs, sculptures, paintings) from Ancient Egypt in terms of anatomical defects of the chest. The team which analysed artefacts consisted of historians of medicine and thoracic surgeons. The researchers found a relief, depicting a man with an abnormal shape of the chest. The relief was from Niankhkhnum and Khnumhotep mastaba and dates back to circa 2400 BC. The authors think it is possible that the relief may represent a pectus excavatum deformity and believe the image will open up debate on the occurrence of this deformity in ancient times. PMID:25564580

  16. The vacuum bell for conservative treatment of pectus excavatum: the Basle experience

    Microsoft Academic Search

    Frank-Martin Haecker

    2011-01-01

    Objective  Surgical repair of pectus excavatum (PE) in childhood is a well-established procedure. Previously used operative techniques\\u000a to correct PE were largely based on the Ravitch technique. Since about 10 years, the minimally invasive repair (MIRPE) by\\u000a Nuss is well established. Conservative treatment with the vacuum bell to elevate the funnel in patients with PE represents\\u000a a potential alternative to surgery in

  17. Variation of the Anthropometric Index for pectus excavatum relative to age, race, and sex

    PubMed Central

    Rebeis, Eduardo Baldassari; de Campos, Jose Ribas Milanez; Moreira, Luis Felipe Pinho; Pastorino, Antonio Carlos; Pêgo-Fernandes, Paulo Manuel; Jatene, Fabio Biscegli

    2013-01-01

    OBJECTIVES: To determine possible variations in the Anthropometric Index for pectus excavatum relative to age, race, and sex in individuals free of thoracic wall deformities. METHODS: Between 2002 and 2012, 166 individuals with morphologically normal thoracic walls consented to have their chests and the perimeter of the lower third of the thorax measured according to the Anthropometric Index for pectus excavatum. The participant characteristics are presented (114 men and 52 women; 118 Caucasians and 48 people of African descent). RESULTS: Measurements of the Anthropometric Index for pectus excavatum were statistically significantly different between men and women (11–40 years old); however, no significant difference was found between Caucasians and people of African descent. For men, the index measurements were not significantly different across all of the age groups. For women, the index measurements were significantly lower for individuals aged 3 to 10 years old than for individuals aged 11 to 20 years old and 21 to 40 years old; however, no such difference was observed between women aged 11 to 20 years old and those aged 21 to 40 years old. CONCLUSION: In the sample, significant differences were observed between women aged 11 to 40 years old and the other age groups; however, there was no difference between Caucasian and people of African descent. PMID:24141837

  18. Pectus excavatum with delayed diagnosis of implant tear on MRI apparently causing recurrent postoperative seromas: A case report.

    PubMed

    Iyer, Arti R; Powell, Daniel K; Irish, Robert D; Math, Kevin R

    2015-08-01

    Seroma formation is the most common early postoperative complication after pectus excavatum repair, but later seromas are rare. While many seromas eventually resorb or decrease in size after aspiration, our case demonstrates recurrent seroma formation as a late complication of pectus excavatum repair in a patient with an implant tear. Postoperative seromas can result in prolonged chest wall pain, large chest wall masses, and increased mass effect on the heart with potential risk for resultant right ventricular outflow obstruction. This case report illustrates a solid silicone implant tear. Though rare, early recognition may help to decrease the likelihood of recurrent postoperative seromas. PMID:25452151

  19. Assessment of psychosocial functioning and its risk factors in children with pectus excavatum

    Microsoft Academic Search

    Yi Ji; Wenying Liu; Siyuan Chen; Bing Xu; Yunman Tang; Xuejun Wang; Gang Yang; Liming Cao

    2011-01-01

    Background  Psychosocial functioning is poor in patients with pectus excavatum (PE). However, a comprehensive understanding of this issue\\u000a does not exist. The aim of this study was to assess the severity of psychosocial problems as associated with PE, as well as\\u000a to identify its risk factors.\\u000a \\u000a \\u000a \\u000a \\u000a Methods  A comparative study was performed at the Sichuan Academy of Medical Sciences\\/Sichuan Provincial People's Hospital

  20. Body Disfigurement and the Quality of Life of Adolescents with Pectus Excavatum: Effects of the Nuss Procedure

    ERIC Educational Resources Information Center

    Roberts, Jillian; MacMath, Sheryl; English, Margot; Martin, Joan; Hayashi, Al; Sigalet, David L.

    2006-01-01

    This article takes a comprehensive look at the effects of pectus excavatum, a congenital deformity with psychosocial and physical ramifications, and the Nuss procedure on the quality of life of adolescents. The Nuss procedure is a minimally invasive corrective surgery. Twenty-five participants from Calgary, Alberta were interviewed (10 adolescents…

  1. A 3-year experience of a minimally invasive technique for correction of pectus excavatum in Croatia.

    PubMed

    Zganjer, Mirko; Cigit, Irenej; Cizmi?, Ante; Paji?, Anto

    2005-06-01

    The aim of this study was to assess the early results of a three-year experience with the minimally invasive correction of pectum excavatum, which requires no cartilage incision or excision, and no sternal osteotomy. Since 2001 we have performed 35 minimally invasive pectus excavatum procedures at our hospital. A convex steel bar is inserted under the sternum through small bilateral incisions, and removed after 2 years when permanent remolding had occured, the bar is removed. Complications were pneumothorax in 5 patients (only 1 required a thoracostomy tube, the other 4 resolved spontaneously), pneumonia in 3 patients, and bar displacement in 1 patient. The mean follow-up was 3 months to 3 years. Initial excellent results were maintained in 28 patients (normal postoperative chest), good results in 5patients (mild residual pectus) and poor in 2 patients (severe recurrence requiring further treatment). Poor results occurred because the steel bar was too soft in 1 patient, and the sternum too soft in 1 patient with Marfan's syndrome. Our early results with the minimally invesive technique without cartilage incision and resection or sternal osteotomy showed that the procedure is effective with excellent preliminary results. PMID:16117307

  2. Gpr126/Adgrg6 deletion in cartilage models idiopathic scoliosis and pectus excavatum in mice.

    PubMed

    Karner, Courtney M; Long, Fanxin; Solnica-Krezel, Lilianna; Monk, Kelly R; Gray, Ryan S

    2015-08-01

    Adolescent idiopathic scoliosis (AIS) and pectus excavatum (PE) are common pediatric musculoskeletal disorders. Little is known about the tissue of origin for either condition, or about their genetic bases. Common variants near GPR126/ADGRG6 (encoding the adhesion G protein-coupled receptor 126/adhesion G protein-coupled receptor G6, hereafter referred to as GPR126) were recently shown to be associated with AIS in humans. Here, we provide genetic evidence that loss of Gpr126 in osteochondroprogenitor cells alters cartilage biology and spinal column development. Microtomographic and x-ray studies revealed several hallmarks of AIS, including postnatal onset of scoliosis without malformations of vertebral units. The mutants also displayed a dorsal-ward deflection of the sternum akin to human PE. At the cellular level, these defects were accompanied by failure of midline fusion within the developing annulus fibrosis of the intervertebral discs and increased apoptosis of chondrocytes in the ribs and vertebrae. Molecularly, we found that loss of Gpr126 upregulated the expression of Gal3st4, a gene implicated in human PE, encoding Galactose-3-O-sulfotransferase 4. Together, these data uncover Gpr126 as a genetic cause for the pathogenesis of AIS and PE in a mouse model. PMID:25954032

  3. A sensorized Nuss bar for patient-specific treatment of Pectus Excavatum.

    PubMed

    Betti, Stefano; Ciuti, Gastone; Ricotti, Leonardo; Ghionzoli, Marco; Cavallo, Filippo; Messineo, Antonio; Menciassi, Arianna

    2014-01-01

    Pectus Excavatum is an anatomical deformation characterized by a depression of the anterior chest wall. Nuss technique (representing the current clinical golden standard) consists in the introduction of a corrective metal bar, in order to raise the sternum in its anatomic natural position. Nowadays, the bar plays purely a mechanical/corrective action and is kept implanted for about three years, supporting up to a maximum force of 250 N. Our study aims at optimizing the procedure of correction, in terms of monitoring the bar effect, minimizing the body response, and facilitating the bar removal. The sensorized Nuss bar prototype inserted in a platform for telemedicine described in this article is able to monitor in vitro pressure data variations, with more than 150 discrete measurements during the operating period. This behavior is promising for future clinical applications, in which the device could be exploited to monitor the forces at work, thus, providing a customized therapeutic protocol, which in turn may optimize the period of implant. The sensorized bar was also provided with a polymeric coating, able to influence human dermal fibroblast behavior in vitro. This highlights the possibility to minimize, in future in vivo applications, tissue fibrotic responses. PMID:25268912

  4. Automatic modeling of pectus excavatum corrective prosthesis using artificial neural networks.

    PubMed

    Rodrigues, Pedro L; Rodrigues, Nuno F; Pinho, A C M; Fonseca, Jaime C; Correia-Pinto, Jorge; Vilaça, João L

    2014-10-01

    Pectus excavatum is the most common deformity of the thorax. Pre-operative diagnosis usually includes Computed Tomography (CT) to successfully employ a thoracic prosthesis for anterior chest wall remodeling. Aiming at the elimination of radiation exposure, this paper presents a novel methodology for the replacement of CT by a 3D laser scanner (radiation-free) for prosthesis modeling. The complete elimination of CT is based on an accurate determination of ribs position and prosthesis placement region through skin surface points. The developed solution resorts to a normalized and combined outcome of an artificial neural network (ANN) set. Each ANN model was trained with data vectors from 165 male patients and using soft tissue thicknesses (STT) comprising information from the skin and rib cage (automatically determined by image processing algorithms). Tests revealed that ribs position for prosthesis placement and modeling can be estimated with an average error of 5.0 ± 3.6mm. One also showed that the ANN performance can be improved by introducing a manually determined initial STT value in the ANN normalization procedure (average error of 2.82 ± 0.76 mm). Such error range is well below current prosthesis manual modeling (approximately 11 mm), which can provide a valuable and radiation-free procedure for prosthesis personalization. PMID:25070021

  5. A Sensorized Nuss Bar for Patient-Specific Treatment of Pectus Excavatum

    PubMed Central

    Betti, Stefano; Ciuti, Gastone; Ricotti, Leonardo; Ghionzoli, Marco; Cavallo, Filippo; Messineo, Antonio; Menciassi, Arianna

    2014-01-01

    Pectus Excavatum is an anatomical deformation characterized by a depression of the anterior chest wall. Nuss technique (representing the current clinical golden standard) consists in the introduction of a corrective metal bar, in order to raise the sternum in its anatomic natural position. Nowadays, the bar plays purely a mechanical/corrective action and is kept implanted for about three years, supporting up to a maximum force of 250 N. Our study aims at optimizing the procedure of correction, in terms of monitoring the bar effect, minimizing the body response, and facilitating the bar removal. The sensorized Nuss bar prototype inserted in a platform for telemedicine described in this article is able to monitor in vitro pressure data variations, with more than 150 discrete measurements during the operating period. This behavior is promising for future clinical applications, in which the device could be exploited to monitor the forces at work, thus, providing a customized therapeutic protocol, which in turn may optimize the period of implant. The sensorized bar was also provided with a polymeric coating, able to influence human dermal fibroblast behavior in vitro. This highlights the possibility to minimize, in future in vivo applications, tissue fibrotic responses. PMID:25268912

  6. Metal/polymer composite Nuss bar for minimally invasive bar removal after Pectus Excavatum treatment: FEM simulations.

    PubMed

    Ricotti, Leonardo; Ciuti, Gastone; Ghionzoli, Marco; Messineo, Antonio; Menciassi, Arianna

    2014-12-01

    This study aims at assessing the mechanical behavior of a composite metal/polymer bar to be implanted in the retrosternal position, in order to correct chest wall deformities, such as Pectus Excavatum. A 300-mm-long, 12.7-mm-wide, and 3.5-mm-thick Nuss bar was considered, made of different metals and biodegradable polymers, fixed at its extremities, and with a constant force of 250?N applied on its center. Two different geometries for the metal elements to be embedded in the polymeric matrix were tested: in the former, thin metal sheets and in the latter, cylindrical metal reinforcing rods were considered. Finite element method simulation results are reported, in terms of maximum stress and strain of the bar. Furthermore, the maximum stress values obtained by varying metal sheet thickness or rod diameter (and therefore the volumetric percentage of metal within the matrix) for different material combinations are also shown; optimal configuration for the Pectus Excavatum treatment was finally identified for a composite Nuss bar. PMID:25208771

  7. Correction of pectus excavatum with a self-retaining seagull wing prosthesis. Long-term follow-up.

    PubMed

    Actis Dato, G M; De Paulis, R; Actis Dato, A; Bassano, C; Pepe, N; Borioni, R; Panero, G B

    1995-02-01

    Between June 1958 and December 1991, 315 patients (217 male and 98 female, mean age = 17.8 +/- 5.5 years) affected by pectus excavatum (PE) were surgically treated. Most of the patients required operation for aesthetic reasons only (299 patients; 95 percent). The grade of PE (Chin classification) was I in 72 patients, II in 152, and III in the remaining 91. The surgical technique consisted of a double transversal sternotomy at the level of the lowest and highest part of the depression associated with a longitudinal sternotomy. A wedge resection of the ribs was then performed and the sternum was fixed using a stainless steel strut molded into a seagull wing prosthesis. The strut was removed 12 months postoperatively. There were no operative mortalities. Four patients had sternal wound infection that was successfully treated. The mean follow-up was 15.8 years per patient and was 60 percent complete. From the aesthetic point of view, the postoperative results were excellent in 246 patients (78 percent), good in 57 (18 percent), and poor in 12 (4 percent). All subjective symptoms, when present, disappeared after surgery. The seagull wing prosthesis appears to be safe, easy to implant and to remove, and comfortable for the patient. This technique has shown good long-term results independently of type of deformity and patient age. PMID:7842751

  8. Sternal Cleft and Pectus Excavatum: A Combined Approach for the Correction of a Complex Anterior Chest Wall Malformation in a Teenager.

    PubMed

    Tocchioni, Francesca; Ghionzoli, Marco; Lo Piccolo, Roberto; Deaconu, Diana E; Facchini, Flavio; Milanez De Campos, Jose R; Messineo, Antonio

    2015-06-01

    Congenital sternal cleft is a rare chest wall malformation. Because of the flexibility of the chest in infants, surgical repair should be performed by primary closure in the neonatal period. In adolescents and adults, different techniques have been suggested to overcome the lack of sternal bone tissue. We describe a very rare case of an 18-year-old woman with a complete bifid sternum associated with pectus excavatum for whom a satisfactory cosmetic and functional result was obtained by adequate surgical planning, which entailed a combination of two standardized surgical techniques. PMID:26046903

  9. Pectus excavatum repair

    MedlinePLUS

    ... any allergies your child may have to medicine, latex, tape, or skin cleaner During the days before ... up, take deep breaths, and get out of bed and walk. These activities will help healing. At ...

  10. Technical innovation in minimally invasive repair of pectus excavatum.

    PubMed

    Rygl, Michal; Vyhnanek, M; Kucera, A; Mixa, V; Kyncl, M; Snajdauf, J

    2014-01-01

    The aim of study was to introduce technical innovation of MIRPE which reduces the risk of cardiac injury. Modification of MIRPE method with semiflexible thoracoscope and sternum elevating technique has been used. Volkmann bone hook has been inserted percutaneously to the sternum. The hook elevates the sternum forward and enlarges the retrosternal space for safer passage of thoracoscopically guided introducer. Using semiflexible thoracoscope allows better view from various angles via one site of insertion. During the period 2005-2012, the MIRPE was performed on 29 girls and 151 boys; the mean age at the time of surgery was 15.9 years (range 13-18.7 years). The mean Haller index was 4.7 (range 2.7-20.5). The most common complication was pneumothorax (3.3 %) and the incidence of bar displacement was 2 %. The most serious complication was cardiac perforation when inserting Lorenz introducer. This occurred in a 16-year-old girl; she required urgent sternotomy with right atrial repair and recovered well. External elevation of sternum with the hook was used since this case. Subsequent 113 patients underwent surgery without any serious complications. Technical innovation using semiflexible thoracoscope and hook elevation of the sternum reduces the risk of cardiac injury. The hook opens the anterior mediastinum space effectively and makes the following dissection relatively safe and straightforward. PMID:24292408

  11. Surgical repair of pectus carinatum.

    PubMed

    Saxena, A K; Willital, G H

    1999-01-01

    Pectus carinatum represents a variety of protrusion deformities of the anterior chest wall. Although various non-operative methods of treatment have been employed, surgery has been widely accepted as the only effective method for the correction of pectus carinatum. We evaluate our 14 year single center experience of pectus carinatum correction on 111 patients using a uniform technique of internal stabilization employing stainless steel struts. Operative correction required double bilateral chondrotomy parasternally and at points of transition to normal ribs, followed by detorsion of the sternum, retrosternal mobilization and correction of the everted sternum as well as of the everted and inverted ribs. The mobilized sternum after incomplete wedge osteotomy was finally stabilized by one transternal and two bilateral parasternal metal struts. The corrections were completed with successful repair in 109 patients (98.2%). Major recurrences in 2 patients (1.8%) were corrected while mild recurrence were observed in 3 patients (2.7%). PMID:10667812

  12. Enhancement by gonyautoxin V of the iron(III) reducing or binding activity produced by the dinoflagellate, Alexandrium excavatum

    Microsoft Academic Search

    James E. Stewart

    2011-01-01

    Reduction or binding of Fe(III) by agent(s) produced by a highly toxigenic strain of Alexandrium excavatum was detected at approximately the same levels in culture filtrates of this dinoflagellate grown either axenically or non-axenically. Nanomolar concentrations of pure Paralytic Shellfish Poisons (PSP) produced by this phytoplankton, the carbamate toxins saxitoxin, 2\\/3 gonyautoxin or the N-sulfamoyl carbamate toxins C1\\/C2, added to

  13. In vitro acaricidal effect of plant extract of neem seed oil ( Azadirachta indica) on egg, immature, and adult stages of Hyalomma anatolicum excavatum (Ixodoidea: Ixodidae)

    Microsoft Academic Search

    S. Abdel-Shafy; A. A. Zayed

    2002-01-01

    Effects of the plant extract of neem seed (Azadirachta indica) on eggs, immature, and adult stages of Hyalomma anatolicum excavatum was studied at concentrations of 1.6, 3.2, 6.4, and 12.8%. The extract was found to have a significant effect on the hatching rate of eggs. It significantly increased the hatching rate during the first 7 days post-treatment (DPT) giving incompletely

  14. Anti-Inflammatory and Analgesic Effects of the Marine-Derived Compound Excavatolide B Isolated from the Culture-Type Formosan Gorgonian Briareum excavatum

    PubMed Central

    Lin, Yen-You; Lin, Sung-Chun; Feng, Chien-Wei; Chen, Pei-Chin; Su, Yin-Di; Li, Chi-Min; Yang, San-Nan; Jean, Yen-Hsuan; Sung, Ping-Jyun; Duh, Chang-Yih; Wen, Zhi-Hong

    2015-01-01

    In recent years, several marine-derived compounds have been clinically evaluated. Diterpenes are secondary metabolites from soft coral that exhibit anti-inflammatory, anti-tumor and cytotoxic activities. In the present study, we isolated a natural diterpene product, excavatolide B, from cultured Formosan gorgonian Briareum excavatum and investigated its anti-inflammatory activities. We found that excavatolide B significantly inhibited the mRNA expression of the proinflammatory mediators, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), in lipopolysaccharide (LPS)-challenged murine macrophages (RAW 264.7). We also examined the anti-inflammatory and anti-nociceptive effects of excavatolide B on intraplantar carrageenan-induced inflammatory responses. Excavatolide B was found to significantly attenuate carrageenan-induced nociceptive behaviors, mechanical allodynia, thermal hyperalgesia, weight bearing deficits and paw edema. In addition, excavatolide B inhibited iNOS, as well as the infiltration of immune cells in carrageenan-induced inflammatory paw tissue. PMID:25923315

  15. Características y tratamiento del trastorno obsesivo resistente al tratamiento

    Microsoft Academic Search

    Daniel Navarro Bayón

    Este artículo presenta el perfil clínico del trastorno obsesivo resistente a las intervenciones terapéuti- cas de primera elección (cognitivo-conductuales y farmacológicas). No existen criterios claros en la definición del concepto de resistencia al tratamiento para los pacientes obsesivos. Para considerar a un paciente como resistente se pueden considerar los siguientes criterios: el paciente ha recibido un mí- nimo de dos

  16. Neoplasias mielodisplásicas o mieloproliferativas: Tratamiento (PDQ®)

    Cancer.gov

    Resumen de información revisada por expertos acerca del tratamiento de las neoplasias mielodisplásicas o mieloproliferativas, incluso las leucemias mielomonocíticas crónicas o juveniles, y la LMC atípica.

  17. Deletion of short arm of chromosome 18, Del(18p) syndrome.

    PubMed

    Babaji, Prashant; Singh, Anurag; Lau, Himani; Lamba, G; Somasundaram, P

    2014-01-01

    Deletion of the short arm of chromosome 18 is a rare syndrome clinically presenting with variable mental retardation, growth retardation, low height, pectus excavatum, craniofacial malformations including long ear, ptosis, microcephaly and short neck. This case report presents with characteristic features along with rare feature of single nostril. PMID:24531606

  18. Investigación sobre el tratamiento de cáncer

    Cancer.gov

    La Iniciativa de Respuestas Excepcionales (Exceptional Responders Initiative), un estudio que investiga los factores moleculares de los tumores en pacientes de cáncer que responden en forma excepcional al tratamiento con medicamentos, se inició hoy bajo la guía del Instituto Nacional del Cáncer (NCI). Los científicos tratarán de identificar en los tumores las características moleculares que predicen si un medicamento o una clase de medicamento en particular será beneficioso o no.

  19. El uso de la neuromodulación para el tratamiento del temblor

    PubMed Central

    Bendersky, Damián; Ajler, Pablo; Yampolsky, Claudio

    2014-01-01

    Introducción: El temblor puede ser un desorden incapacitante y el tratamiento de primera línea para estos pacientes es farmacológico. Sin embargo, este tratamiento puede llevar a una reducción satisfactoria del temblor en sólo el 50% de los pacientes con temblor esencial. La talamotomía era el tratamiento de elección para el temblor refractario al tratamiento médico hasta que comenzó a utilizarse la estimulación cerebral profunda (ECP) del núcleo ventral intermedio (Vim) del tálamo. En la actualidad, raramente se realiza la talamotomía. Métodos: Este artículo es una revisión no sistemática de las indicaciones, resultados, parámetros de programación y técnica quirúrgica de la ECP del Vim para el tratamiento del temblor. Resultados: Aunque los resultados clínicos son similares usando la talamotomía o la ECP del Vim, la primera causa más efectos adversos que la última. Además, la ECP puede ser usada bilateralmente, mientras que la talamotomía tiene un alto riesgo de causar disartria cuando se realiza de ambos lados. La ECP del Vim logró una adecuada mejoría del temblor en varias series de pacientes con temblor causado por temblor esencial, enfermedad de Parkinson o esclerosis múltiple. Además del Vim, hay otros blancos que están siendo usados por varios autores, tales como la zona incerta y las radiaciones prelemniscales. Conclusión: La ECP del Vim es un tratamiento útil para el temblor incapacitante refractario al tratamiento médico. Es esencial realizar una precisa selección de pacientes, así como utilizar una técnica quirúrgica correcta. Aún se desconoce el mejor blanco estereotáctico para el temblor, aunque el Vim es el más usado. PMID:25165613

  20. Flail chest stabilization with Nuss operation in presence of multiple myeloma

    PubMed Central

    Lee, Song Am; Hwang, Jae Joon; Chee, Hyun Keun; Kim, Yo Han

    2014-01-01

    Nowadays the Nuss operation has been widely adopted as a minimally invasive procedure and standard surgical choice in pectus excavatum. However, much debate and concern have been raised regarding its applicability in adults with pectus excavatum flail chest and other thoratic wall deformities, as compared with younger patients, in terms of complications after surgery. To stabilize the segment of paradoxical chest wall movement we performed the Nuss operation on a patient with multiple myeloma who sustained blunt thoracic trauma. The patient presented with paradoxical movement of the thoracic wall and sternum instability due to multiple myeloma, which led to severe dyspnea, hypoxemia, hypercapnea, and bedridden state. His condition progressed to acute respiratory distress syndrome and did not respond to conservative treatment. We performed the Nuss operation on the patient, and his clinical symptoms were relieved after surgery. The patient regained the ability to walk unassisted and was discharged from the hospital without any specific events. PMID:24822124

  1. Shprintzen-Goldberg marfanoid syndrome: a case followed up for 24 years.

    PubMed

    Stoll, C

    2002-01-01

    A patient with Shprintzen-Goldberg syndrome was followed up for 24 years. The patient's parents were unrelated and unaffected. Walking and speech were delayed. Facial dysmorphism was obvious as well as pectus excavatum, scoliosis, bilateral dislocation of the radial heads, hammer toes and hallux valgus, pes planus, arachnodactyly, and camptodactyly. Skin was thin and fragile. CT scan showed ventricular enlargement. He had a mitral valve prolapse. He was operated on twice for bilateral inguinal and crural hernia and several times for his foot deformities. Puberty was delayed until 18 years. At 24 years of age he was still thin, dolichocephalic, and the facial dysmorphic features were still obvious. Pectus excavatum was still severe but the thoracolumbar scoliosis was mild. His foot deformities had improved and his joints were less hypermobile. Psychomotor development was quite normal. His main concern was the minimal subcutaneous fat and fragility of skin. Echocardiography was now normal. PMID:11822698

  2. PAQUETES TECNOLÓGICOS PARA EL TRATAMIENTO DE DATOS EN INVESTIGACIÓN EN

    Microsoft Academic Search

    EDUCACIÓN MATEMÁTICA

    En este artículo se presentan algunas aplicaciones de paquetes tecnológicos para el tratamiento y análisis de datos en educación matemática. Para tal fin se efectúa un estudio documental, a partir del cual se clasifican los paquetes tecnológicos de acuerdo a diversos criterios de autores como Algarabel y Sanmartín, Valles, Buendía, Colás y Hernández. Se toma en cuenta los tipos de

  3. Base molecular de la fenilcetonuria: Del genotipo al tratamiento clínico

    Microsoft Academic Search

    Johannes Zschocke

    2010-01-01

    ResumenEn la era de la detección sistemática neonatal y el tratamiento presintomático de individuos con fenilcetonuria, la definición de la enfermedad ha variado desde una serie de síntomas clínicos observados en pacientes no tratados, hasta una predisposición hereditaria necesitada de una intervención alimentaria para evitar el daño cerebral y el deterioro intelectual. En consecuencia, el análisis de correlaciones entre genotipo

  4. Programa de análisis molecular para la elección de tratamientos del NCI (NCI-MATCH)

    Cancer.gov

    Información sobre el Programa de análisis molecular para la elección de tratamientos del NCI (NCI-MATCH), en el cual los investigadores examinarán tejidos de tumor de pacientes con tumores sólidos y linfomas avanzados que han dejado de responder al tratamiento.

  5. Fumar durante el tratamiento de cáncer–para profesionales de salud (PDQ®)

    Cancer.gov

    Resumen de información revisada por expertos acerca de la influencia de seguir fumando sobre el tratamiento del cáncer y el riesgo de segundos cánceres. Se mencionan las intervenciones que estimulan dejar el hábito de fumar.

  6. Cánceres poco comunes en la niñez: Tratamiento–para profesionales de salud (PDQ®)

    Cancer.gov

    Resumen de información revisada por expertos acerca del tratamiento de los cánceres poco comunes en la niñez como los cánceres de la cabeza y el cuello, el tórax, el abdomen, el aparato reproductor, la piel y otros.

  7. Warfarin-Associated Diaphragmatic Hernia: An Unusual Diagnosis

    PubMed Central

    Vilhena, Cristina; Gameiro, Cátia; Tomás, Cláudia; Santos, Antónia; Ilgenfritz, Raquel

    2015-01-01

    Fetal warfarin syndrome is a consequence of maternal intake of warfarin during pregnancy and comprises a wide range of manifestations, including some typical facial dysmorphologic features. The authors report a case of prenatal ultrasonographic diagnosis of warfarin embryopathy in an obese woman on unsupervised warfarin prophylaxis at the 16th week of gestation. The fetus presented with facial dysmorphism, pectus excavatum, diaphragmatic hernia, and pulmonary hypoplasia. To the best of our knowledge, this is the second reported case of warfarin-associated diaphragmatic hernia.

  8. Tratamiento psicológico de la cefalea. Predicción de la mejoría en un acercamiento activo-pasivo

    Microsoft Academic Search

    María I. Comeche; Miguel A. Vallejo; Marta I. Díaz

    Este trabajo pretende estudiar las va ri ables que pudieran predecir la eficacia de dos acercamientos dis- tintos al tratamiento psicológico de las cefaleas pr i m a ri a s : en uno se potencia la implicación activa del paciente y su implicación pasiva en el otro. 21 pacientes de cefalea fueron asignados a 2 grupos. El pri- mer

  9. Variaciones en el tratamiento de las sibilantes Inconsistencia en el seseo sevillano: Un enfoque sociolingüístico

    E-print Network

    Gonzalez-Bueno, Manuela

    1993-04-01

    linguisticos. Una de estas causas, muy importante, a mi en- tender, es el tratamiento que los rasgos dialectales andaluces reciben en los libros de texto de EGB (Ensenanza General Basica, equivalents a la ensenanza primaria) y BUP (Bachiller Unificado... Polivalente, equivalente a la ensenanza secundaria). A causa de [esta] valorati6n [...],la contiencialinguisticade los hablantes andaluces se debate en la actualidad entre el complejo de inferioridad y la acepta- ti6n, con tierto orgullo, de la propia...

  10. -ESTUDIO Y TRATAMIENTO DEL DOLOR Los alumnos que hayan cursado los crditos obligatorios en el Mster Oficial que se

    E-print Network

    Rey Juan Carlos, Universidad

    procedentes de otros estudios oficiales de posgrado. En esos casos, la transferencia y reconocimiento de- ESTUDIO Y TRATAMIENTO DEL DOLOR Los alumnos que hayan cursado los créditos obligatorios en el Máster Oficial que se imparte en la actualidad, podrán solicitar su adaptación al nuevo plan de estudios

  11. Abnormalities of the lungs and thoracic cage in the Ehlers-Danlos syndrome.

    PubMed Central

    Ayres, J G; Pope, F M; Reidy, J F; Clark, T J

    1985-01-01

    Twenty patients with the Ehlers-Danlos syndrome, (10 type I, six type II, and four type IV) were studied to assess the frequency of respiratory abnormalities in this condition. Five patients (25%) had had at least one episode of haemoptysis, but none had any defect of coagulation. There was a high frequency of recurrent sinusitis, notably in those with the type I syndrome. Two patients had bullous lung disease, one of whom (type IV) had had three pneumothoraces and subsequent pleurodesis; he also had tracheomegaly (the Mounier-Kuhn abnormality). Minor skeletal abnormalities such as pectus excavatum were common, particularly in patients with type IV disease. Three patients had the straight back syndrome. There were no consistent spirometric or lung volume abnormalities, but eight patients (40%) had a raised gas transfer coefficient (Kco), possibly due to an increased intrapulmonary vascular volume. Two other patients had very low values of Kco that were unexplained. Images PMID:4023980

  12. Early detection of chromosome 9q22.32q31.1 microdeletion and the nevoid basal cell carcinoma syndrome.

    PubMed

    de Ravel, Thomy J L; Ameye, Liliane; Ballon, Katleen; Borghgraef, Martine; Vermeesch, Joris R; Devriendt, Koen

    2009-01-01

    We report on a patient with a microdeletion of chromosome region 9q22.32q31.1 including the PTCH1 gene (human homologue of the Drosophila patched 1 gene), review the findings in the reported patients with similar array CGH findings, and highlight the non nevoid basal cell carcinoma/non-Gorlin syndrome findings at an earlier age. These are macrocephaly, neonatal hypotonia, severe psychomotor retardation with markedly delayed motor milestones and speech development, epicanthic folds, a thin upper lip, a short and wide/webbed neck, pectus excavatum and (kypho)scoliosis. These features should alert the physician to an early diagnosis of the microdeletion and allow the initiation of essential clinical management hereof. PMID:19233320

  13. Congenital dyserythropoietic anemia type I presenting as persistent pulmonary hypertension with pigeon chest deformity.

    PubMed

    El-Sheikh, Ayman A; Hashem, Hasan; Holman, Carol; Vyas, Yatin M

    2014-08-01

    Congenital dyserythropoietic anemia (CDA) type-1 is a rare genetic disorder of ineffective erythropoiesis, which manifests in macrocytic anemia. We report a CDA1 patient who as a newborn presented with macrocytic anemia and persistent pulmonary hypertension of the newborn (PPHN) requiring mechanical ventilation. Post-infancy, the patient developed acral dysmorphism and pectus excavatum the latter rarely found in CDA1. Patient is a compound heterozygote for a known maternal-derived missense-mutation (c.1796A?>?G/p.Asn589Ser) and a novel paternal-derived deletion-mutation (c.1104_1106del/Phe365del) in CDAN1. This report highlights the importance of recognizing PPHN as a presenting symptom of CDA1 and expands the repertoire of the accompanying mutations and axial skeletal malformations. PMID:24420417

  14. A de novo 3.57 Mb microdeletion in 8q12.3q13.2 in a patient with mild intellectual disability and epilepsy.

    PubMed

    Verhoeven, Willem M A; Egger, Jos I M; Feenstra, Ilse; de Leeuw, Nicole

    2012-05-01

    A female patient, nine years of age, is reported with a history characterized by delay of psychomotor and speech development, mild to moderate intellectual disability and persistent sleep disturbances since the age of two. The patient showed facial dysmorphisms, a pectus excavatum and a sandal gap. Apart from lowered intelligence, neuropsychological functioning disclosed impaired attentional capacities and executive control as well as weak motor skills. Genome wide SNP array analysis revealed a 3.57 Mb de novo microdeletion in band q12.3 of chromosome 8. The long lasting sleep disorders turned out to originate from a rare juvenile epilepsy, continuous spike-waves during slow sleep (CSWS) syndrome, that includes the electrical status epilepticus in sleep (ESES) phenomenon. MRI-scanning of the brain showed no abnormalities. To the authors knowledge, this is the first report of a de novo 8q12.3q13.2 microdeletion syndrome that presents with ESES/CSWS. PMID:22138216

  15. Tratamiento Quirúrgico de los Meningiomas del Foramen Óptico, Técnicay Resultados de una Serie de 18 Pacientes

    PubMed Central

    Goldschmidt, Ezequiel; Ajler, Pablo; Campero, Álvaro; Landriel, Federico; Sposito, Maximiliano; Carrizo, Antonio

    2014-01-01

    Introducción: los meningiomas del foramen óptico producen un rápido deterioro de la función visual aún cuando su tamaño es pequeño, por eso su diagnóstico y manejo difiere del resto de los meningiomas clinoideos. El propósito de este estudio es presentar la técnica y los resultados de nuestro manejo quirúrgico de meningiomas foraminales (MF). Pacientes y Métodos: se llevó a cabo una revisión de las historias clínicas de 47 pacientes con meningiomas primarios intraorbitarios. Se realizaron 52 cirugías en los pacientes con MF. Se empleó una craneotomía fronto-orbitaria, seguida de una descompresión extradural del canal óptico, resección del componente intraorbitario y exploración intradural del nervio óptico. Resultados: de los 12 pacientes con MF que presentaban la visión conservada, la agudeza visual fue preservada en 7 casos, mejoró en 2, y empeoró en 3. En 18 pacientes, el principal síntoma fue exoftalmos y en 35 pacientes ceguera unilateral. Ocurrieron 6 recurrencias, 2 a 10 años después de la resección quirúrgica. Cinco de ellos fueron reoperados. Se indicó radioterapia después de la recurrencia en 3 pacientes. Conclusión: el manejo de los MF continúa siendo controvertido y frecuentemente se propone un tratamiento conservador. Basados en nuestros hallazgos de frecuente extensión intracraneal, proponemos realizar una resección total o subtotal del tumor, preservando el nervio óptico en pacientes con visión prequirúrgica conservada. PMID:25165616

  16. Tratamiento del dolor agudo

    Microsoft Academic Search

    E. Blanco-Tarrío

    2010-01-01

    Acute pain is a physiological short-term response to an adverse stimulus associated with surgery, trauma or acute disease. A correct evaluation should be made, using simple, quick and useful pain intensity scales.The best interventional strategy should be to achieve a greater well-being with the least adverse effects. This should take into account the patient risk profile and the comorbidities.Acetaminophen (paracetamol)

  17. Validity and Reliability of the Turkish Version of the Nuss Questionnaire Modified for Adults

    PubMed Central

    Bahadir, A. Tugba; Kuru, Pinar; Afacan, Ceyda; Ermerak, Nezih Onur; Bostanci, Korkut; Yuksel, Mustafa

    2015-01-01

    Background Pectus excavatum (PE) is the most common chest wall deformity. The Nuss Questionnaire modified for Adults (NQmA) is a disease-specific health-related quality of life assessment tool for patients with pectus deformities. The aim of this study is to adapt the NQmA into Turkish. Methods Two hundred and sixty-five patients with PE were participated, with an age range of 14 to 29 years. All patients underwent a physical examination and had not undergone corrective surgery. The Turkish version of the NQmA was completed by patients and their parents. Results The content validity index based on expert opinions was 91% for the patient questionnaire and 96% for the parent questionnaire. The Cronbach’s alpha value for the NQmA was found to be 0.805 for the patient questionnaire and 0.800 for the parent questionnaire. Exploratory factor analysis was used to assess construct validity. Two factors explained 51.1% of the total variance in the patient questionnaire (psychosocial: 31.145%, Cronbach’s alpha=0.818; physical: 19.955%, Cronbach’s alpha=0.862). In the parent questionnaire, two factors explained 51.422% of the total variance (psychosocial: 26.097%, Cronbach’s alpha=0.743; physical: 25.325%, Cronbach’s alpha=0.827). Construct validity was confirmed by confirmatory factor analysis. Conclusion The Turkish version of the NQmA was found to be valid and reliable for the assessment of quality of life in patients with PE. PMID:25883894

  18. Importance of a multidisciplinary approach and monitoring in fetal warfarin syndrome.

    PubMed

    Silveira, Daniélle B; da Rosa, Ernani B; de Mattos, Vinicius F; Goetze, Thayse B; Sleifer, Pricila; Santa Maria, Fernanda D; Rosa, Rosana C M; Rosa, Rafael F M; Zen, Paulo R G

    2015-06-01

    Warfarin is a synthetic oral anticoagulant that crosses the placenta and can lead to a number of congenital abnormalities known as fetal warfarin syndrome. Our aim is to report on the follow-up from birth to age 8 years of a patient with fetal warfarin syndrome. He presented significant respiratory dysfunction, as well as dental and speech and language complications. The patient was the second child of a mother who took warfarin during pregnancy due to a metallic heart valve. The patient had respiratory dysfunction at birth. On physical examination, he had a hypoplastic nose, pectus excavatum, and clubbing of the fingers. Nasal fibrobronchoscopy showed upper airway obstruction due to narrowing of the nasal cavities. He underwent surgical correction with Max Pereira graft, zetaplasty, and osteotomies for the piriform aperture. At dental evaluation, he had caries and delayed eruption of the upper incisors. Speech and language assessment revealed high palate, mouth breathing, little nasal patency, and shortened upper lip. Auditory long latency and cognitive-related potential to auditory stimuli demonstrated functional changes in the cortical auditory pathways. We believe that the frequency of certain findings observed in our patient may be higher in fetal warfarin syndrome than is appreciated, since a significant number result in abortions, stillbirths, or children evaluated in the first year of life without a follow-up. Thus, a multidisciplinary approach and long-term monitoring of these patients may be necessary. © 2015 Wiley Periodicals, Inc. PMID:25899236

  19. Gastrointestinal manifestations in diploid/triploid mixoploidy.

    PubMed

    Lalani, Farida K; Elsner, Garrett L; Lebel, Robert Roger; Beg, Mirza B

    2015-06-01

    A girl infant was delivered by cesarean section at 32 weeks of gestation because of growth arrest and poor movement patterns. The infant had feeding problems, which were based on gastroesophageal reflux, laryngomalacia, and decreased gut motility. Hypotonia was notable from the outset, and the patient eventually displayed significant delays in both motor and cognitive milestones. Meanwhile, lymphocytes had yielded a normal karyotype (46,XX), but at 2 years of age the patient underwent a skin biopsy and mosaicism because a 68,XX cell line was discovered in fibroblasts. At the age 6.4 years, the patient is short of stature below the 3rd percentile but has a weight at the 42nd percentile and head circumference above the 97th percentile. Other phenotypic features include low-set ears, piebald irides and scalp hair, eyelid ptosis, strabismus, broad nasal bridge, anteverted nares, upswept eyebrows, hypoplastic teeth, pectus excavatum, hypoplastic labia, scoliosis, 3-4 finger syndactyly, and 2-3 toe syndactyly. We present this case with a review of the literature for mixoploidy (the rare event of mosaicism for diploid and triploid cell lines). We add to the existing data on the clinical features of diploid/triploid mixoploidy. The complexities of the gastrointestinal problems make this case unusual. PMID:25373857

  20. Moyamoya disease associated with asymptomatic mosaic Turner syndrome: a rare cause of hemorrhagic stroke.

    PubMed

    Manjila, Sunil; Miller, Benjamin R; Rao-Frisch, Anitha; Otvos, Balint; Mitchell, Anna; Bambakidis, Nicholas C; De Georgia, Michael A

    2014-01-01

    Moyamoya disease is a rare cerebrovascular anomaly involving the intracranial carotid arteries that can present clinically with either ischemic or hemorrhagic disease. Moyamoya syndrome, indistinguishable from moyamoya disease at presentation, is associated with multiple clinical conditions including neurofibromatosis type 1, autoimmune disease, prior radiation therapy, Down syndrome, and Turner syndrome. We present the first reported case of an adult patient with previously unrecognized mosaic Turner syndrome with acute subarachnoid and intracerebral hemorrhage as the initial manifestation of moyamoya syndrome. A 52-year-old woman was admitted with a subarachnoid hemorrhage with associated flame-shaped intracerebral hemorrhage in the left frontal lobe. Physical examination revealed short stature, pectus excavatum, small fingers, micrognathia, and mild facial dysmorphism. Cerebral angiography showed features consistent with bilateral moyamoya disease, aberrant intrathoracic vessels, and an unruptured 4-mm right superior hypophyseal aneurysm. Genetic analysis confirmed a diagnosis of mosaic Turner syndrome. Our case report is the first documented presentation of adult moyamoya syndrome with subarachnoid and intracerebral hemorrhage as the initial presentation of mosaic Turner syndrome. It illustrates the utility of genetic evaluation in patients with cerebrovascular disease and dysmorphism. PMID:24103673

  1. Sudden death in a patient with idiopathic scoliosis.

    PubMed

    Satoh, Fumiko; Fujita, Masaki Q; Seto, Yoshihisa; Tsuboi, Akio; Takeichi, Sanae

    2006-01-01

    We report an autopsy case of sudden death in a 36-year-old craftsman with idiopathic scoliosis. The doctor identified his scoliosis at the age of thirteen, and he was under medical care for three years until he stopped consulting the doctor. He collapsed while walking at the station and was sent to an emergency room in cardiopulmonary arrest state, where he was declared dead in spite of more than an hour of CPR. Numbers of petechiae were seen on the bilateral palpebral conjunctivae and the lips were cyanotic. There were no particular injuries except for small abrasions observed on the face. The back showed right rib hump owing to midthoracic scoliosis (with 73 degrees of Cobb's angle) and right hemithorax was deformed showing an appearance of pectus excavatum in the front. The volume of the right thoracic cavity was significantly decreased. In the right lung, there was extensive stromal fibrosis, leaving almost no normal alveolar structures, and medial hypertrophy of pulmonary arteriolar walls. Hypertrophy of the right heart ventricle due to these pulmonary changes and the congestion of other organs suggested that the cause of death in this case was cor pulmonale due to pulmonary hypertension. This was a rare case of fatal outcome of advanced idiopathic scoliosis without medical care in spite of early detection through mass screening. PMID:17023193

  2. Herrmann multiple synostosis syndrome with neurological complications caused by spinal canal stenosis.

    PubMed

    Edwards, M J; Rowe, L; Petroff, V

    2000-11-13

    A young man was found to have multiple synostosis syndrome type I after presenting with a neck injury causing a cervical spinal cord contusion. Neurological symptoms and signs suggested spinal cord compression. Magnetic resonance (MR) and computerized tomography (CT) imaging of the spine showed spinal canal stenosis with cord compression at C3-C6, a deformed spinal canal flattened in the anteroposterior dimension, vertebral fusions and deformed lateral processes of the vertebrae. He had a long broad nose with hypoplasia of the alae nasi, conductive hearing loss requiring hearing aids, muscular build, stiff spine, prominent acromia, pectus excavatum, ischial prominences, short fifth fingers, fusion at the proximal interphalangeal joints of the fifth fingers with indistinct overlying creases, and toe syndactyly. Spinal cord stenosis is a serious complication of multiple synostosis syndrome, that should be kept in mind in considering the risk of neck or back injury associated with certain sports or other activities. In both the multiple synostosis syndrome and the less severe proximal symphalangism deafness syndrome, mutations have been detected in the human homologue of the noggin gene on chromosome 17q21-q22. PMID:11078560

  3. A new X-linked syndrome with agenesis of the corpus callosum, mental retardation, coloboma, micrognathia, and a mutation in the Alpha 4 gene at Xq13.

    PubMed

    Graham, John M; Wheeler, Patricia; Tackels-Horne, Darci; Lin, Angela E; Hall, Bryan D; May, Melanie; Short, Kieran M; Schwartz, Charles E; Cox, Timothy C

    2003-11-15

    We describe two brothers with a unique pattern of malformations that includes coloboma (iris, optic nerve), high forehead, severe retrognathia, mental retardation, and agenesis of the corpus callosum (ACC). Both boys have low-set cupped ears with sensorineural hearing loss, normal phallus, pectus excavatum, scoliosis, and short stature. One brother had choanal atresia and cardiac defects consisting of ventricular septal defect (VSD) and patent ductus arteriosus (PDA) which resolved spontaneously. Differential diagnosis between a number of clinical entities was considered, however, because ACC and the distinctive facial features were reminiscent of FG syndrome, DNA was analyzed for markers linked to the FGS1 locus at Xq13-q21. Notably, the brothers were concordant for markers spanning this presumed FG region, and in both we have identified adjacent alterations (-57delT and T-55A) in the Alpha 4 gene located within this interval. Alpha 4 is a regulatory subunit of the major cellular phosphatase, PP2A, that has recently been shown to interact with MID1, the product of the gene mutated in X-linked Opitz GBBB syndrome. The double nucleotide change identified in this family was not observed in 410 control chromosomes, suggesting that it may be a pathogenetic change. Altered expression of Alpha 4, through either a change in translational efficiency, mRNA stability or splicing, could explain the clinical phenotype in these boys and the phenotypic overlap with Opitz GBBB syndrome. PMID:14556245

  4. Modern CT applications in veterinary medicine.

    PubMed

    Garland, Melissa R; Lawler, Leo P; Whitaker, Brent R; Walker, Ian D F; Corl, Frank M; Fishman, Elliot K

    2002-01-01

    Although computed tomography (CT) is used primarily for diagnosis in humans, it can also be used to diagnose disease in veterinary patients. CT and associated three-dimensional reconstruction have a role in diagnosis of a range of illnesses in a variety of animals. In a sea turtle with failure to thrive, CT showed a nodal mass in the chest, granulomas in the lungs, and a ball in the stomach. CT of a sea dragon with balance and movement problems showed absence of the swim bladder. In a sloth with failure to thrive, CT allowed diagnosis of a coin in the intestine. CT of a puffin with failure to thrive showed a mass in the chest, which was found to be a hematoma. In a smooth-sided toad whose head was tilted to one side and who was circling in that direction, CT showed partial destruction of the temporal bone. CT of a domestic cat with listlessness showed a mass with focal calcification, which proved to be a leiomyosarcoma. CT of a sea otter showed pectus excavatum, which is caused by the animal smashing oysters against its chest. In a Japanese koi with abdominal swelling, CT allowed diagnosis of a hepatoma. PMID:11796898

  5. A new mutation in the C-SH2 domain of PTPN11 causes Noonan syndrome with multiple giant cell lesions.

    PubMed

    Carapito, Raphael; Paul, Nicodème; Untrau, Meiggie; Ott, Louise; Corradini, Nadège; Poignant, Sylvaine; Geffroy, Loïc; Caldagues, Emmanuelle; Heymann, Marie-Françoise; Cassagnau, Elisabeth; Isidor, Bertrand; Bahram, Seiamak

    2014-01-01

    Noonan syndrome (NS), an autosomal dominant multisystem disorder, is caused by the dysregulation of the RAS-MAPK pathway and is characterized by short stature, heart defects, pectus excavatum, webbed neck, learning problems, cryptorchidism and facial dysmorphism. We here present the clinical and molecular characterization of a family with NS and multiple giant cell lesions (MGCLs). The proband is a 12-year-old girl with NS and MGCL. Her mother shows typical NS without MGCL. Whole-exome sequencing of the girl, her mother and her healthy maternal grand parents revealed a previously unobserved mutation in exon 5 of the PTPN11 gene (c.598 A>T; p.N200Y), transmitted from the mother to the proband. As no other modification in the RAS-MAPK pathway genes as related to Rasopathies was detected in the proband, this report demonstrates for the first time that a unique mutation affecting this, otherwise unaffected signaling route, can cause both NS and NS/MGCL in the same family. This observation further confirms that NS/MGCL is not a distinct entity but rather that MGCL represents a rare complication of NS. Moreover, the localization of the p.N200Y mutation suggests an alternative molecular mechanism for the excessive phosphatase activity of the PTPN11-encoded protein. PMID:24225993

  6. Varicose veins of lower extremities in pregnant women and birth outcomes.

    PubMed

    Bánhidy, Ferenc; Acs, Nándor; Puhó, Erzsébet H; Czeizel, Andrew E

    2010-09-01

    The objective of the study was to estimate the association of pregnant women with varicose veins of lower extremities (VVLE) and the possible risk for adverse birth outcomes and among them different congenital abnormalities (CAs) in their children. Prospectively and medically recorded VVLE were evaluated in 332 pregnant women who delivered infants with CA (case group) and 566 pregnant women with VVLE who delivered infants without CA (control group) and matched to cases were compared in the population-based data set of the Hungarian Case-Control Surveillance System of Congenital Abnormalities, 1980-1996. About one-quarter of pregnant women had chronic VVLE while new onset VVLE occurred in the rest of pregnant women. There was no higher risk for adverse birth outcomes of pregnant women with VVLE, in fact the rate of preterm birth and low birth weight was somewhat lower than in the newborns of pregnant women without VVLE. The comparison of VVLE occurrence in pregnant women who had offspring with 21 different CA groups and in pregnant women who later delivered babies without CA showed a higher risk only for pectus excavatum, a mild CA. In conclusion, VVLE in pregnant women does not associate with obvious hazard for their fetuses. PMID:21033612

  7. Clinical report: Two patients with atelosteogenesis type I caused by missense mutations affecting the same FLNB residue.

    PubMed

    Li, Ben C; Hogue, Jacob; Eilers, Meg; Mehrotra, Pavni; Hyland, James; Holm, Tara; Prosen, Tracy; Slavotinek, Anne M

    2013-03-01

    We present two patients with Atelosteogenesis Type I (AO type I) caused by two novel Filamin B (FLNB) mutations affecting the same FLNB residue: c.542G > A, predicting p.Gly181Asp and c.542G > C, predicting p.Gly181Arg. Both children had typical manifestations of AO type I, with severe rhizomelic shortening of the extremities, limited elbow and knee extension with mild webbing, pectus excavatum, broad thumbs with brachydactyly that was most marked for digits 3-5, dislocated hips and bilateral talipes equinovarus. Facial features included proptosis, hypertelorism, downslanting palpebral fissures, cleft palate, and retromicrognathia. The clinical course of one child was influenced by airway instability and bronchopulmonary dysplasia that complicated intubation and prevented separation from ventilator support. Respiratory insufficiency with tracheal hypoplasia, laryngeal stenosis, and pulmonary hypoplasia have all been described in patients with AO type I and we conclude that compromised pulmonary function is a major contributor to morbidity and mortality in this condition. PMID:23401428

  8. Tratamiento de Fibromialgia mediante Hipnosis

    Microsoft Academic Search

    F. Martínez Pintor; I. Pérez Hidalgo; J. Chamorro Álvarez; N. Martí Gasulla; A. Reig Gourlot

    2006-01-01

    Summary Nowadays the treatment of chronic pain syndrome such asfibromyalgia, only with the use of medication results obviously insufficient as we check in our every doy attendance. Considering the relevance ofthe emotional stress in the causes ofmany ofthese syndromes and also the con- cept of neuron plasticity, we decided to initiate a study inside a more general treatment which included

  9. Germline TGF-beta receptor mutations and skeletal fragility: a report on two patients with Loeys-Dietz syndrome.

    PubMed

    Kirmani, Salman; Tebben, Peter J; Lteif, Aida N; Gordon, David; Clarke, Bart L; Hefferan, Theresa E; Yaszemski, Michael J; McGrann, Pamela S; Lindor, Noralane M; Ellison, Jay W

    2010-04-01

    Loeys-Dietz syndrome (LDS, OMIM # 609192) caused by heterozygous mutations in TGFBR1 and TGFBR2 has recently been described as an important cause of familial aortic aneurysms. These patients have craniofacial and skeletal features that overlap with the Marfan syndrome (MFS), and more importantly, have significant vascular fragility as is seen in MFS and Ehlers-Danlos syndrome Type IV (EDS-IV). The skeletal phenotype with respect to low bone mineral density and skeletal fragility is not clear. We present two patients with LDS with significant skeletal fragility. The first is a 17-year-old male who had talipes equinovarus, diaphragmatic and inguinal and herniae, aortic root dilatation necessitating surgical repair, craniofacial and skeletal dysmorphism consistent with LDS, and a history of numerous fragility fractures leading to significant skeletal deformity. He was found to be heterozygous for a c.923T > C transition in exon 4 of TGFBR2. The second is a 26-year-old male with submucous cleft palate, talipes equinovarus, pectus excavatum requiring surgery, inguinal hernia, and aneurysms in the ascending aorta, abdominal aorta, carotid, subclavian, vertebral and brachial arteries requiring surgical repairs. He also had craniofacial and skeletal dysmorphism consistent with LDS, multiple fractures in childhood, low bone mineral density, and was found to be heterozygous for a c.1561 T > C transition in exon 7 of TGFBR2. These case studies highlight the importance of paying close attention to fractures and bone density in patients with LDS. Osteopenia or osteoporosis may become increasingly important issues as earlier detection and treatment of the vascular complications of LDS improves life expectancy in these patients. PMID:20358619

  10. Efectos adversos del tratamiento del cáncer oral

    Microsoft Academic Search

    F. J. Silvestre-Donat; A. Puente Sandoval

    2008-01-01

    SUMMARY In this article a revision of most frequent adverse effects of head and neck surgery, radiotherapy and chemotherapy is maid, because frequently general dentists deal with complications at their practises like mucositis, xerostomia, osteonecrosis, taste alterations and other pathologies which will cause disturbances to the patients, affecting their quality of live. The role of the dentist in the multidisciplinary

  11. Tratamientos psicológ icos eficaces para la agorafobia

    Microsoft Academic Search

    Arturo Bados López

    2001-01-01

    Efficacious psychological treatments for agoraphobia. In vivo exposure and cognitive-behavioral the - rapy have demonstrated their efficacy f or ag oraphobic anxiety and avoidance; however, the ef fects of cognitive-behavioral ther apy might be smaller if time g iven to in vivo exposure is r educed. Cogniti- ve-behavioral ther ap y is also a probably ef ficacious treatment f or

  12. Avances en el tratamiento de la amiloidosis

    Microsoft Academic Search

    Fernando Martinez-Valle; Mercedes Gironella Mesa; Roser Solans-Laqué

    Amyloidosis is a clinical disorder caused by extracellular deposition of proteins that are normally soluble as insoluble fibrils that damage different organs. More than 20 proteins can form amyloid deposits. All types of amyloid fibrils have a secondary structure with a ? folded shape that is characteristic and makes them to adopt a green birefringence after stained with Congo red

  13. Tratamiento con fulvestrant en mujeres posmenopáusicas con cáncer de mama avanzado tras tratamiento hormonal previo

    Microsoft Academic Search

    Virginia Martínez Marín; Andrés J. Muñoz Martín; M. Carmen Viñuela Benéitez; Pilar García Alfonso; Antonio Alonso Muñoz; Gumersindo Pérez Manga

    2009-01-01

    Background and objectiveFulvestrant (Flv) is a pure antiestrogen without agonist activity. Flv is effective as second line treatment in postmenopausal women with advanced breast cancer after tamoxifen.

  14. Chromosome 10q tetrasomy: First reported case

    SciTech Connect

    Blackston, R.D.; May, K.M.; Jones, F.D. [Emory Univ., Atlanta, GA (United States)] [and others

    1994-09-01

    While there are several reports of trisomy 10q (at least 35), we are not aware of previous cases of 10q tetrasomy. We present what we believe to be the initial report of such a case. R.J. is a 6 1/2 year old white male who presented with multiple dysmorphic features, marked articulation problems, hyperactivity, and developmental delays. He is the product of a term uncomplicated pregnancy. There was a normal spontaneous vaginal delivery with a birth weight of 6 lbs. 4oz. and length was 19 1/2 inch. Dysmorphic features include small size, an asymmetrically small head, low set ears with overfolded helixes, bilateral ptosis, downslanting eyes, right eye esotropia, prominent nose, asymmetric facies, high palate, mild pectus excavatum deformity of chest, and hyperextensible elbow joints. The patient is in special needs classes for mildly mentally handicapped students. Chromosome analysis at a resolution of 800 bands revealed a complex rearrangement of chromosomes 10 and 11. The segment 10q25.3 to q16.3 appears to be inverted and duplicated within the long arm of chromosome 10 at band q25.3 and the same segment of chromosome 10 is present on the terminal end of the short arm of chromosome 11. There is no visible loss of material from chromosome 11. Fluorescence in situ hybridization was performed with a chromosome 10 specific {open_quotes}paint{close_quotes} to confirm that all of the material on the abnormal 10 and the material on the terminal short arm of 11 was from chromosome 10. Thus, it appears that the segment 10q25.3 to q26.3 is present in four copies. Parental chromosome studies are normal. We compared findings which differ in that the case of 10q tetrasomy did not have prenatal growth deficiency, microphthalmia, cleft palate, digital anomalies, heart, or renal defects. Whereas most cases of 10q trisomy are said to have severe mental deficiency, our case of 10q tetrasomy was only mildly delayed. We report this first apparent cited case of 10q tetrasomy.

  15. Tratamiento individualizado de la EPOC: una propuesta de cambio

    Microsoft Academic Search

    Marc Miravitlles

    2009-01-01

    Chronic obstructive pulmonary disease (COPD) is a highly prevalent but poorly defined disease and there is wide confusion regarding its treatment. The available knowledge should allow guidelines for specific treatment to be established according to each patient's clinical features. The present article describes a proposal for individually-tailored treatment. Long-acting bronchodilators, alone or in various combinations, would be the basis of

  16. La espiritualidad en el tratamiento del cáncer (PDQ®)

    Cancer.gov

    Resumen de información revisada por expertos acerca de la influencia que tiene la espiritualidad y la religión en las personas que tienen cáncer. Se discuten varios métodos sobre manejo e intervención.

  17. Tratamiento y prevención del síndrome de neurotoxicidad inducido por opioides

    Microsoft Academic Search

    C. CENTENO; E. BRUERA; Grey Nuns

    1999-01-01

    Close attention to patients treated with morphine or drugs derived from it can accelerate the diagnosis of the Opioid Induced Neurotoxicity Syndrome (OIN). It may allow the application of some therapeutic measu- res that provide hopeful results. Rotation of the type of opioid that had been used in combination with suitable hydration have been proved to be an efficient treatment

  18. Tratamiento quirúrgico en pacientes con hipertensión pulmonar tromboembólica crónica

    Microsoft Academic Search

    David Sánchez Lorente; Paolo Macchiarini

    2009-01-01

    Chronic thromboembolic pulmonary hypertension (CTEPH), which has a natural history with low long-term survival, is increasingly being diagnosed. Pulmonary endarterectomy (PE) is the treatment of choice, which can be curative. This technique consists of a true endarterectomy through a midline sternotomy with extracorporeal circulation and periods of hypothermic circulatory arrest. The following procedures should be performed before surgery: transesophageal echocardiogram,

  19. Tratamiento médico en pacientes con hipertensión pulmonar tromboembólica crónica

    Microsoft Academic Search

    Pilar Escribano Subias; María José Ruiz Cano; Ángela Flox

    2009-01-01

    Pulmonary thromboendarterectomy is the treatment of choice in patients with chronic thromboembolic pulmonary hypertension (CTEPH). However, specific medical treatment of pulmonary hypertension (PH) can be an alternative or play a complementary role to surgery. Thus, in patients unsuitable for surgery due to distal thrombotic obstruction, residual or persistent PH after surgery or very severe PH and a high-risk hemodynamic profile,

  20. Tratamiento de los síndromes periódicos asociados a la criopirina (CAPS)

    Microsoft Academic Search

    Santiago Jiménez Treviño; Eduardo Ramos Polo

    2011-01-01

    Non-steroidal anti-inflammatories, corticoids and antihistamines, as well as a great many other molecules, have classically been used to control the symptoms of cryopyrin-associated periodic syndromes (CAPS), with very few encouraging results. Knowledge of its genetic character, and its aetiopathogenesis associated with inflammasome and the production of interlekin-1 (IL-1) has led to the development of new therapeutic weapons that have not

  1. HEMORRAGIA DIGESTIVA ALTA AGUDA NO VARICOSA: TRATAMIENTO DE LA RECIDIVA

    Microsoft Academic Search

    Magna Adolfina Maidana; Sandra Elizabet Sesin; Marcos Ormella; Fernando David Boudot

    The upper gastrointestinal bleeding is the loss of blood into the light of digestive tract, caused by lesions, localized between the upper esophageal sphincter and the treiz angle. The recurrence, is defined as the presence of haematemesis or haemorrhagic signs of activity (hematico gastric aspirates and \\/ or melena) associated of hypovolaemia (PAS<100mmHg and \\/ or FC> 100 lat. \\/

  2. Tratamiento fisioterápico de la epicondilitis en un tenista joven

    Microsoft Academic Search

    M. Menayo Antúnez; R. Menayo Antúnez; J. P. Fuentes García; D. Sanz Rivas

    2005-01-01

    This case-study analyzed the physical therapy applied to a young tennis player with tennis elbow. It was placed in an interdisciplinary health team system for recovery based on the collaboration of physical therapist and trainer, permitting a rigorous and objective analysis of the different aspects considered as determinants for the injury, as well as the seriousness, the causes that provoked

  3. Tratamientos psicológ icos eficaces para el trastorno bipolar

    Microsoft Academic Search

    Carmen Lorenzo

    Efficacious psychological treatments for bipolar disorder. The bipolar disorder is a chronic dysfunc- tion and a illness condition f or many people. Their treatment has been classically pharmacological (lit - hium), although in the last y ears it has been demonstrated that its combina tion with different psycho- logical treatments allows a bigg er impr ovement in these patients. The

  4. Citología con atipias en células glandulares. Evaluación, tratamiento y resultados

    Microsoft Academic Search

    Daniel Andía Ortiz; Enrique Izaguirre Gondra; Borja Rivero Torrejón; Mikel Goitia Ibarra

    2006-01-01

    ObjectiveTo study the frequency of a cytological result of atypical glandular cells of unknown significance\\/atypical glandular cells, not otherwise specified (AGUS\\/GAC-NOS) in the pap smear and the final diagnosis in patients with this result.

  5. El grano y la criba de los tratamientos psicológ icos

    Microsoft Academic Search

    Marino Pérez

    Se presentan las conclusiones de revisar la eficacia (así como la efectividad) terapéutica par a los ca- torce tr astornos psicológ icos siguientes: Esquizofrenia, Drogadicción, Anor exia y Bulimia, Trastornos de Personalidad, Hipocondría, Trastorno Obsesivo Compulsivo, Disfunciones Se xuales, Ansiedad Ge- neralizada, Fobias Específicas, Agorafobia, Trastorno de Pánico, Trastorno por Estrés P ost-traumáti- co, Depresión unipolar y De presión bipolar

  6. Como Lo Hago Yo: Tratamiento Quirurgico Del Mielomeningocele

    PubMed Central

    Portillo, Santiago

    2014-01-01

    En Argentina hay plan de fortificación con ácido fólico. Diagnostico prenatal no siempre es correcto. Cierre según técnica. Cerramos músculo. No favorecemos corpectomía temprana en casos de cifosis. Suturamos la plaqueta. Cerramos el plano muscular. Hidrocefalia: Válvula de derivación, generalmente dentro de los dos primeros meses. Ventriculostomía no está indicada. Chiari II. Laminectomia cervical alta. Siringomielia: Derivación desde la cavidad al peritoneo. PMID:24791219

  7. ESTUDIO CINETICO DE LA DEGRADACION DE LA ACTIVIDAD ANTIOXIDANTE HIDROSOLUBLE DE JUGOS CITRICOS POR TRATAMIENTO TERMICO

    Microsoft Academic Search

    Belén ACEVEDO; Mabel MONTIEL; Jorge AVANZA

    In this work we have studied the degradation of Antioxidant Activities by thermic treat- ment at 70, 80 y 90ºC in juices of varios citrus: orange (Citrus sinensis), mandarins (Citrus reticu- lata), lemon (Citrus limon), pomelo (Citrus paradisi) y lime Rangpur (Citrus limonia Osbeck). Antioxidant Activities were measured using the DPPH method. Antioxidant Activities degradation follows a zero-order reaction.

  8. Várices por insuficiencia de la vena perforante poplítea. Nuestra experiencia en el diagnóstico y tratamiento quirúrgico

    Microsoft Academic Search

    Jorge A. Pozzi

    Introduction: Until recently, popliteal perforator vein insufficiency was not considered as a source of varicose veins. The study of its diagnosis and treatment must be considered by the vascular surgeon to avoid varicose recurrences at the popliteal region. Objectives: To show the results of the diagnostic and therapeutic measures in limbs with popliteal perforator vein insufficiency and its complications. Patients

  9. Sigla: MAT-224. Cronograma de tratamiento de los contenidos Profesora: I Markina.

    E-print Network

    Markina, Irina

    .00. SEMANA CONTENIDOS Julio 21 ­ Julio25 Espacios topológicos y espacios medibles. Funciones medibles, composición funciones continuas y medibles. Álgebra de Borel. Limites superiores y inferiores. Funciones simples, aproximación de funciones medibles por funciones simples. Julio 28 ­ Agosto 1 Medidas positivas

  10. Radioterapia preoperatoria frente a cirugía como tratamiento en el carcinoma de recto

    Microsoft Academic Search

    María del Carmen Fernández Fernández; Luis Errázquin de Sáenz Tejada; María Dolores Jiménez Gamero; Carmen Cordero Fernández

    2001-01-01

    Resumen  El propósito fue realizar un estudio retrospectivo de 133 pacientes afectados por un carcinoma rectal en el cual se ha comparado\\u000a la supervivencia, la supervivencia libre de recurrencia local y las complicaciones de 61 pacientes tratados con radioterapia\\u000a preoperatorio con 72 pacientes tratados solamente con cirugía.\\u000a \\u000a En cuanto al material y los métodos, se realizó un estudio retrospectivo de 61

  11. Evaluación de un componente de inducción al tratamiento con adolescentes usuarios de alcohol del Distrito Federal

    Microsoft Academic Search

    Martha Leticia; Salazar Garza; Kalina Isela Martínez Martínez; Vania Barrientos Casarrubias

    2009-01-01

    SUMMARY There are two main problems reported in the intervention programs addressing teenage substance users: 1) limited admission to treatment, 2) high drop out rates. Institutions in other countries working with teenage substance users report a dropout rate between 50 and 70% after the first session at early treatment stages. In Mexico, a study on dropout rates in a brief

  12. Láser infrarrojo frente a acupuntura en el tratamiento del espolón calcáneo

    Microsoft Academic Search

    A. Orellana Molina; A. Hernández Díaz; P. J. Larrea Cox; S. Fernández Yanes; B. M. González Méndez

    2010-01-01

    IntroductionPhysical Medicine and Rehabilitation and Traditional and Natural Medicine are medical specialties that develop measures for the promotion of health, prevention, diagnosis and treatment, using physiotherapy and natural agents, along with acupuncture and therapeutic laser. The heel spur is an osteophyte that grows in the front part of the plantar tuberosity of the heel bone secondary to inflammatory processes of

  13. Tratamiento hormonal de reasignación de sexo en España: nuestra experiencia en 236 casos

    Microsoft Academic Search

    Antonio Becerra Fernández; María Jesús Lucio Pérez; José Luis Llopis Agelan

    2007-01-01

    IntroductionIn recent decades, demand for gender reassignment therapy (psychological, hormonal and surgical) has significantly increased. In Spain, this type of therapy has not generally been provided in public hospitals. Consequently, endocrinologists and other health professionals have insufficient experience of this treatment and transsexuals have to resort to self therapy or to private hospitals.

  14. Tratamiento de Afecciones Músculo-Esqueléticas con Ondas de Choque Extracorpóreas

    Microsoft Academic Search

    Juan Luis

    Summary Extracorporeal shock waves are pressure waves used to treat certain musculoskeletal conditions. Focused wave therapy, the same that is used in lithotripsy, but acting through a different mechanism, is used to treat pseudoar- thritis and delayed consolidation, avascular necrosis of large joints, osteochondritis dissecans, calcific tendoni - tis and enthesopathies. We study its use in myocardial infarction. Results are

  15. RESULTADOS DEL TRATAMIENTO QUIRÚRGICO DE LOS NEU ROMAS INTERDIGITALES MEDIANTE TÉCNICAS MÍNIMAMENTE INVASIVAS

    Microsoft Academic Search

    Señarís J; Baamonde C; Aizpurúa J; Prego A; Arriaza R

    SUMMARY In the last years diverse minimally invasive techni- ques have been developed for the treatment of foot pathologies. In case of the interdigital neuromas, it has proposed to realize percutaneal osteotomies of t the adjacent metatarsal neck to the injury, as well as the percutaneal liberation of the intermetatarsal ligament of the sympathetic space, with the aim of decompress

  16. Gliomas del adulto: acercamiento al diagnóstico y tratamiento Gliomas in adults: diagnostic and therapeutical approach

    Microsoft Academic Search

    Germán Alonso; Reyes Botero

    SUMMARY Gliomas are the most common primary malignancies of central nervous system. Progress in neuroradiology with use of magnetic resonance imaging allows establishing diagnosis in earlier when an opportune treatment can be perfformed. Even though prognosis is poor for this group of patients, evidence has showed that treatments with surgery, radiotherapy and chemotherapy have a significant impact in quality of

  17. Tratamiento farmacológico de la mujer embarazada: fármacos contraindicados durante la gestación

    Microsoft Academic Search

    E. Rodríguez-Pinilla; M. L. Martínez-Frías

    As primary care doctors treat pregnant women and those of fertile age, they must decide which treatments they should follow. Therefore, they have to confront the difficult situation of assessing the risks that different alternative treatments may have on embryo\\/foetal development. An assessment that is not straightforward as established general guidelines may not be applicable. For example, one drug may

  18. Cmo expresar sus deseos sobre su cuidado y tratamiento 450 Brookline Ave.

    E-print Network

    Liu, Xiaole Shirley

    podría obtener. Se necesita la toma seria de decisiones médicas al considerar las numerosas opciones.dana-farber.org Decisiones para cuidados de salud: planificación por adelantado Usted tiene derecho a tomar las decisiones decisiones médicas por sí mismo. En Massachusetts, la persona que usted elige se denomina apoderado de

  19. EL USO DE LA VISUALIZACIÓN EN EL TRATAMIENTO PSICOLÓGICO DE ENFERMOS DE CÁNCER

    Microsoft Academic Search

    María Valiente

    2006-01-01

    The article is attempting to offer a histo- rical vision on the evolution and beginning of technology of visualization. He gave a brief review on his different uses and his clinical application up to the present about patients with cancer. Finally, included in the article is the called visualization of the Simonton Therapy, refe- rring to the controversy provoke on

  20. La hipnosis como adjunto en el tratamiento del hábito de fumar. Estudio de caso

    Microsoft Academic Search

    María Elena; Mendoza Figueroa

    2000-01-01

    Se presenta el caso de una paciente de 33 años con dependencia a la nicotina que lle vaba 9 años fu- mando una media de 35 cigarrillos diarios. Intentó dejarlo hace 3 años pero tuvo una recaída a los seis meses por problemas de ansiedad y continuó con su adicción. El tr atamiento tuvo como objetivo que la paciente dejara

  1. SIMULACIÓN MATEMÁTICA DE UN DIGESTOR ANAEROBIO TIPO TANQUE AGITADO PARA EL TRATAMIENTO DE VERTIDOS RESIDUALES

    Microsoft Academic Search

    Jorge DEL REAL OLVERA; Francisco PRIETO GARCÍA; Eva María; SANTOS LÓPEZ

    2009-01-01

    In the last years, mathematical modeling has been used to try to represent the chemi- cal changes that occur in the environment. Traditionally the models are based on the mass balance and the kinetic chemistry of the bioprocesses. In this study the equations obtained for a biological isothermal reactor type shaken tank are applied and simulated by using adimensional linear

  2. La depresión con inicio temprano: prevalencia, curso natural y latencia para buscar tratamiento

    Microsoft Academic Search

    Corina Benjet; Guilherme Borges; Ma Elena Medina-Mora; Clara Fleiz-Bautista; Joaquín Zambrano-Ruiz

    2004-01-01

    Objective. To estimate the prevalence of early onset de- pression in the Mexican population and compare its natural history, comorbidity and treatment latency between early onset and adult onset depression. Material and Meth- ods. The National Survey of Psychiatric Epidemiology (ENEP) is representative of the Mexican urban population aged 18 to 65. The diagnostic instrument is the Composite Interna- tional

  3. AVANCES EN EL TRATAMIENTO COGNITIVO-CONDUCTUAL DEL TRASTORNO DE ESTRÉS POSTRAUMÁTICO

    Microsoft Academic Search

    Enrique Echeburúa; Paz de Corral

    This paper deals with a review of the literature on cognitive-behavioral treatment for post-traumatic stress disorder. Addresses 2 issues: different types of victims (rape victims as well as victims of natural disasters and motor vehicle ac- cidents) and different sets of treatments (exposure based procedures, eye movement desensitization and reprocessing, and anxiety management tech- niques). The relevance of this review

  4. Situación de la braquiterapia en España. Análisis de complejidad y tiempos de preparación y tratamiento

    Microsoft Academic Search

    José López Torrecilla; Ernesto Bataller Alonso

    2001-01-01

    Resumen  Se ha analizado la situación de la braquiterapia en los hospitales españoles y valorado la complejidad y el tiempo que se\\u000a emplea en la realización de las aplicaciones.\\u000a \\u000a En mayo de 1999 se envió una encuesta, dividida en 2 partes a 71 servicios de Oncología Radioterápica. La primera tenía por\\u000a objeto conocer la carga asistencial del servicio y la segunda

  5. Paralelizacion y Optimizacion a bajo nivel de algoritmos de tratamiento de imagenes

    E-print Network

    Granada, Universidad de

    im´agenes tienen una alta demanda de CPU, lo cual se traduce en un elevado consumo de tiempo de tiempo de ejecuci´on del soft- ware mediante una gran cantidad de t´ecnicas difer- entes: aumento de la procesamiento de datos en tiempo real. Centr´andonos en las t´ecnicas utilizadas en este art´iculo, cabe

  6. TRATAMIENTO DE EFLUENTES DE DESTILERÍA EN UN FILTRO ANAEROBIO DE FLUJO ASCENDENTE

    Microsoft Academic Search

    Alejandro RIVERA; Jorge S. GONZÁLEZ; Reinaldo CASTRO; Barbarita GUERRERO; Gertrudis NIEVES

    The possibility of using an upflow anaerobic filter, packed with Raschig rings, for the treatment of distillery effluents was demonstrated. Mantaining a hydraulic retention time of 48 hours, organic loads varying from 0.20 to 10.52 kg COD\\/m 3 day were applied. COD removal efficiencies over 65 % were achieved with only one pass through the reactor, for organic loads below

  7. TÉCNICAS FISIOTERÁPICAS Y OSTEOPÁTICAS EN EL TRATAMIENTO DE LA CEFALEA TENSIONAL

    Microsoft Academic Search

    ELISA ROMERO OLUCHA; ROBERT ROIG REQUENA

    The tension-type headache is a problem that affects a lot of people, but nowadays it hasn't yet been determined with certainty the etiology of the problem, and therefore the various proposed treatments are more or less effective, although neither the totally eradicated.

  8. Ensayo no aleatorizado del tratamiento con acupuntura de la cefalea resistente a terapias convencionales

    Microsoft Academic Search

    E. Collazo

    2010-01-01

    ObjectivesTo evaluate the overall effectiveness of acupuncture as a complementary therapy in relieving chronic pain in paired groups (before-after) of patients with headache refractory to conventional therapies in a real life clinical setting. To determine the extent to which analgesic consumption is reduced in these patients after an acupuncture cycle. To determine the adverse reactions due to acupuncture.

  9. Un caso de cefalea post traumática: consideraciones sobre clasificación, fisiopatología y tratamiento

    Microsoft Academic Search

    M. G. Meli

    2010-01-01

    Case report of a 35 year old woman with a post traumatic headache (PTH). Onset of the pain three years earlier, after falling on the ground, which required resuscitation. She had to be on mechanical ventilation for 11 days and suffered several contusions on the right frontal-temporal area of the skull. On discharge, she complained of a continuous bilateral tension

  10. La espiritualidad en el tratamiento del cáncer–para profesionales de salud (PDQ®)

    Cancer.gov

    Resumen de información revisada por expertos acerca de la influencia que tiene la espiritualidad y la religión en las personas que tienen cáncer. Se discuten varios métodos sobre manejo e intervención.

  11. Klinefelter's syndrome presenting with leg ulcers.

    PubMed

    De Morentin, Helena Martinez; Dodiuk-Gad, Roni P; Brenner, Sarah

    2004-01-01

    A 54-year-old man of Persian origin presented to our department with a 1-year history of ulcers on the right leg that had been unresponsive to numerous topical treatments, accompanied by lymphedema of the right leg. Medical history included hypergonadotropic hypogonadism, which had not been further investigated. He was treated for 20 years with testosterone IM once monthly, which he stopped a year before the current hospitalization for unclear reasons. The patient reported no congenital lymphedema. Physical examination revealed two deep skin ulcers (Figure 1) on the right leg measuring 10 cm in diameter with raised irregular inflammatory borders and a boggy, necrotic base discharging a purulent hemorrhagic exudate. Bilateral leg pitting edema and right lymphangitis with lymphadenitis were noted. He had low head hair implantment, sparse hair on the body and head, hyperpigmentation on both legs, onychodystrophia of the toenails (mainly the large toe and less prominent on the other toes), which was atrophic lichen-planus-like in appearance and needed no trimming (Figure 2), normal hand nails, oral thrush, and angular cheilitis. Other physical findings were gynecomastia, pectus excavatum, small and firm testicles, long extremities, asymmetrical goiter, systolic murmur 2/6 in left sternal border, and slow and inappropriate behavior. The patient's temperature on admission was 39 degrees C. Blood cultures were negative for bacterial growth. Results of laboratory investigations included hemoglobin (11.2 g/dL), hematocrit (26.8%), normal mean corpuscular volume and mean corpuscular hemoglobin volume, and red blood cell distribution width (16%). Blood smear showed spherocytes, slight hypochromia, anisocytosis, macrocytosis, and microcytosis. Blood chemistry values were taken for iron (4 micro g/dL [normal range 40-150 micro g/dL]), transferrin (193 mg/dL [normal range 220-400 mg/dL]), ferritin (1128 ng/mL [normal range 14-160 ng/mL]), transferrin saturation (1.5% [normal range 20%-55%]), serum folate (within normal limits), and vitamin B12 (within normal limits). Direct Coombs' test equaled positive 2 + IgG. All these values indicated anemia of chronic diseases combined with hemolytic anemia. Further blood work-up tested antinuclear antibody (positive <1:80 homogeneous pattern), rheumatoid factors (143 IU/mL [positive >8.5 IU/mL]), C-reactive protein (286 mg/L [normal range 0-5 mg/L]), anticardiolipin IgM antibody (9.0 monophosphoryl lipid U/mL [normal range 0-7.00 MPL U/mL]) and antithrombin III activity (135% [normal range 74%-114%]). Results of other blood tests were within normal limits or negative, including lupus anticoagulant, beta2 glycoprotein, anticardiolipin IgG Ab, anti-ss DNA Ab, C3, C4, anti-RO, anti-LA, anti-SC-70, anti-SM Ab, P-ANCA, C-ANCA, TSH, FT4, anti-T microsomal, antithyroglobulin, protein C activity, protein S free, cryoglobulins, serum immunoelectrophoresis, VDRL, hepatitis C antibodies, hepatitis B antigen, and human immunodeficiency virus. Endocrinological work-up examined luteinizing hormone (22.9 mIU/mL [normal range for adult men 0.8-6 mIU/mL]), follicle stimulating hormone (49.7 mIU/mL [normal range for adult men 1-11 mIU/mL]), testosterone (0.24 ng/mL [normal range for adult men 2.5-8.0 ng/mL]), bioavailable testosterone (0.02 ng/mL [normal range for adult men >0.6 ng/mL]), and percent bioavailable test (8.1% [normal value >20%]). These results indicate hypergonadotropic hypogonadism. Plasminogen activator inhibitor 1 was 6 U (normal value 5-20 U/mL). Karyotyping performed by G-banding technique revealed a 47 XXY karyotype, which is diagnostic of Klinefelter's syndrome. Doppler ultrasound of the leg ulcers disclosed partial thrombus in the distal right femoral vein. X-rays and bone scan displayed osteomyelitis along the right tibia. Histological examination of a 4-mm punch biopsy from the ulcer border revealed hyperkeratosis, acanthosis, hypergranulosis, and mixed inflammatory infiltrate containing eosinophils compatible with chronic ulcer. Multiple vessels were seen, compatible with a h

  12. Use of extracorporeal membrane oxygenation in the management of septic shock with severe cardiac dysfunction after Ravitch procedure.

    PubMed

    Vohra, Hunaid A; Adamson, Louise; Weeden, David F; Haw, Marcus P

    2009-01-01

    We report the case of an 18-year-old patient who underwent Ravitch procedure for pectus carinatum and subsequently had septic shock develop with severe cardiac dysfunction requiring treatment with extracorporeal membrane oxygenation. We advocate the use of extracorporeal membrane oxygenation in adult patients with intractable cardiorespiratory failure due to sepsis post-thoracic surgery unresponsive to conventional therapy. PMID:19101257

  13. Aerotransportables viables en el área de tratamiento y disposición final de residuos sólidos municipales de Mérida, Yucatán

    Microsoft Academic Search

    Julia Pacheco A

    Solid waste managing and disposal systems can contribute to the dispersion of the microorganisms. The presence and dispersion of bioaerosols from these sites is considered as a potential human health risk for site-workers and surrounding communities. The aim of this work was to quantify and determine the dispersion of bioaerosols, in the area of recycling, composting and disposal of municipal

  14. Prcticas jurdicas entre la asistencia/tratamiento y el castigo/punicin: ideas penales en el Brasil republicano1

    E-print Network

    Boyer, Edmond

    Brasil republicano1 Rivail Carvalho Rolim ­ UEM-CAPES-Brasil2 Resumen A principios de la década de 1940, Brasil cambió su ordenamiento jurídico- penal, introduciendo nuevos principios y postulados para la. ______________________________________________________________________ Palabras claves: cultura jurídico-penal; Brasil Republicano; derechos de los presos

  15. Variabilidad en la realización de la espirometría y sus consecuencias en el tratamiento de la EPOC en Atención Primaria

    Microsoft Academic Search

    Mònica Monteagudo; Teresa Rodriguez-Blanco; Judith Parcet; Núria Peñalver; Carles Rubio; Montserrat Ferrer; Marc Miravitlles

    2011-01-01

    BackgroundSeveral studies have approached the use of spirometry in the treatment of chronic obstructive pulmonary disease (COPD) in Primary Care (PC), but few have analysed its impact on the treatment of the patient with COPD.

  16. Efecto de la terapia de locomoción refleja combinada con el tratamiento de fisioterapia en lesión medular. Presentación de un caso

    Microsoft Academic Search

    L. Perales López; A. García Heras; I. Delgado; M. Lara Romero

    2011-01-01

    To analyze the effects of inclusion within a Vojta Therapy protocol in the physiotherapy program of a case with a spinal cord injury. A Patient with 6-month old C3-C6 incomplete spinal cord injury, ASIA Scale C. The ASIA Scale sensory-motor assessment, the Walking Index for Spinal Cord Injury, version 2 (Wisci II) Scale for gait analysis and Barthel Scale for

  17. Disminución del dolor y el peso durante el tratamiento de fisioterapia en pacientes intervenidos de prótesis de rodilla

    Microsoft Academic Search

    J. Fortuño Godes; M. Martín Baranera; E. Kadar García; I. Redondo Parra; B. Gallardo Perez

    2010-01-01

    Pain of recently operated patients for total knee prosthesis is the main problem during the first phase of physiotherapy, which is faster and more efficient in non-overweight patients. We performed a randomized clinical trial to demonstrate pain and body weight reduction in obese patients undergoing knee prosthesis through daily biorhythms and physiological protocolized nutrition, exercise, hydration and rest during the

  18. Papel del farmacéutico de hospital en la prevención, identificación y manejo de los efectos adversos asociados al tratamiento antirretroviral

    Microsoft Academic Search

    R. Morillo Verdugo; L. C. Fernández Lisón; M. J. Huertas Fernández; M. T. Martín Conde; J. C. Roldan Morales; R. Ruano Camps; J. I. Serrano López De Las Hazas; O. Ibarra Barrueta; A. Illaro Uranga

    2010-01-01

    At present, the side effects associated with antiretroviral treatment are the main reasons for discontinuation of this kind of therapy, both in clinical trials and in regular clinical practise.On the other hand, due to the change of direction that our profession has suffered in recent years, we face the need to establish a different relationship with the patient, achieving direct

  19. Consenso SER sobre la gestión de riesgo del tratamiento con terapias biológicas en pacientes con enfermedades reumáticas

    Microsoft Academic Search

    Juan Gómez Reino; Estíbaliz Loza; José Luis Andreu; Alejandro Balsa; Enrique Batlle; Juan D. Cañete; Eduardo Collantes Estévez; Cristina Fernández Carballido; José Luis Fernández Sueiro; Rosario García de Vicuña; Isidoro González-Álvaro; Carlos González Fernández; Xavier Juanola; Luis Francisco Linares; José Luis Marenco; Emilio Martín Mola; Manuel Moreno Ramos; Juan Mulero Mendoza; Santiago Muñoz Fernández; Rubén Queiro; Patricia Richi Alberti; Jesús Sanz; Jesús Tornero Molina; Pedro Zarco Montejo; Loreto Carmona

    2011-01-01

    ObjectiveDue to the increasing use of biologic therapy in rheumatic diseases and the importance of its risk management, the Spanish Society of Rheumatology (SER) has promoted the development of recommendations based on the best evidence available. These recommendations should be a reference to rheumatologists and those involved in the treatment of patients who are using, or about to use biologic

  20. Coeliac disease causing symptomatic hypocalcaemia, osteomalacia and coagulapathy

    Microsoft Academic Search

    Bairbre Aine McNicholas; Marcia Bell

    2010-01-01

    A 36-year-old gentleman presented with 6 months of poor energy, tingling in fingers and weight loss with a change in bowel habit. He appeared cachectic and had clubbing, demineralisation of teeth, pectus carinatus, kyphosis, spinal tenderness, proximal muscle weakness and generalised muscle atrophy. Chvostek's and Trosseau's signs were positive. His haemoglobin (Hb) was 8.7 g\\/dl, MCV 64.7 fl with low

  1. Suspensión oftálmica de propóleos-R: una alternativa en el tratamiento de las oftalmopatias en animales afectivos (Ophthalmic suspension of red propolis: an alternative in affective animals)

    Microsoft Academic Search

    B. Hugues; C. J. Soto

    The propólis is a substance resinousbees of having proven properties medicinal antiinfeccion, analgesic and regenerated, having been an employee in the man and the animals. To consider that it can be an useful alternative in the treatment of the phftalmopatics in affective animals, was carried out a study in 25 dogs and 5 cats that suffered of blefaritis, conjunctivitis of

  2. TRATAMIENTO DE LOS CARCINOMAS DE GLOTIS T1N0 CON RADIOTERAPIA. RESULTADOS DE NUESTRO CENTRO Y UNA REVISIÓN DE LA LITERATURA

    Microsoft Academic Search

    X. LEÓN; M. QUER; C. ORÚS; M. DE VEGA; J. VERGÉS; L. GAÑÁN

    ment of patients with T1N0 glottic squamous cell carcino- ma. Material and methods: Retrospective study of a cohort of 338 patients with T1N0 glottic carcinoma treated with radio- therapy at our institution between 1985-1997. A review of the litera- ture published during the last ten years was carried out. Results: Lo- cal control with radiotherapy in our patients was 82%,

  3. INVESTIGACIÓN DE COCAÍNA EN ORINA Y PELO PÚBICO DE PACIENTES FÁRMACODEPENDIENTES BAJO TRATAMIENTO AMBULATORIO *Asdrúbal Lárez. Toxicólogo-Asesor Coordinadora Estadal-Aragua Contra Uso Ilícito de

    Microsoft Academic Search

    Simón Pineda; Elizabeth Henríquez; José Carrasquel; Fac. Ciencias

    The present study is based in a quanti qualitative investigation of cocaine in urine and pubic hair from six masculine patients treated in the rehabilitation center (Foundation José Félix Ribas. Maracay. Venezuela). The technique used for in urine was Inmuno Polarized Fluorescence (TDX); in pubic hair the technique applied was Ultraviolet Spectrophotometry (U.V) and gas chromatography-mass spectrometry (CG-MS). The results

  4. EFECTO DE TRATAMIENTOS CUARENTENARIOS, COMBINANDO FRÍO Y ATMÓSFERAS INSECTICIDAS, SOBRE LA FISIOLOGÍA Y LA CALIDAD NUTRICIONAL Y SENSORIAL DE MANDARINAS 'CLEMENULES

    Microsoft Academic Search

    Cristina Rojas-Argudo; Lluis Palou; Adriana Contreras; M. Bernardita Pérez-Gago; Alicia Marcilla

    2007-01-01

    There is a need to develop new postharvest technologies that contribute to maintain the nutritional and sensory quality of fresh fruits and vegetables. The presence of vitamin C and other bioactive components, most of them with antioxidant activity, in citrus fruits gives them an important nutritional value. The application of quarantine treatments, such as low temperature exposure, might affect their

  5. Cistoprostatectomía radical con preservación neurovascular para el tratamiento del cáncer vesical. Relación con la disfunción eréctil: revisión de la literatura científica

    Microsoft Academic Search

    F. Javier González García; Javier Angulo Cuesta

    2009-01-01

    Radical cystectomy (RC) with bilateral pelvic lymph node dissection and urinary diversion remains the gold standard extirpative treatment for high risk non-invasive bladder cancer and muscleinvasive carcinoma. The endpoints after this operation have been historically focused on cure, urethral recurrence and continence. Functional outcomes in radical cystectomy patients were not considered until the middle eighties, thus the evaluation of these

  6. AFRONTAMIENTO PSICOLÓGICO DE LOS PROCEDIMIENTOS MÉDICOS INVASIVOS Y DOLOROSOS APLICADOS PARA EL TRATAMIENTO DEL CÁNCER INFANTIL Y ADOLESCENTE: LA PERSPECTIVA COGNITIVO- CONDUCTUAL

    Microsoft Academic Search

    Juan Manuel Ortigosa; Francisco Xavier Méndez; Antonio Riquelme

    2009-01-01

    Psychological coping with childhood cancer involves the use of strategies and re- sources that help children and their families undergo the disease with the fewest possible emotional and behavioural problems. In the fi eld of Psychology, techniques and programs have been developed and adapted with the aim of minimising the psychological impact of the diagnosis and treatment of childhood and

  7. Tratamiento de la psoriasis del cuero cabelludo. Revisión de la evidencia y Consenso Delphi del Grupo de Psoriasis de la Academia Española de Dermatología y Venereología

    Microsoft Academic Search

    L. Puig; M. Ribera; J. M. Hernanz; I. Belinchón; J. Santos-Juanes; M. Linares; I. Querol; E. Colomé; G. Caballé

    2010-01-01

    Scalp lesions are common in psoriasis and difficult to treat. Scientific evidence on the topic is scant and fragmentary, especially with respect to long-term treatment. This consensus statement is based on a critical assessment of the results of a MEDLINE search for clinical trials of the efficacy and safety of therapies used to treat scalp psoriasis. The recommendations were developed

  8. Testing road surface treatments to reduce erosion in forest roads in Honduras [Tratamientos de la superficie de rodadura para reducir la erosion en caminos forestales en Honduras

    USGS Publications Warehouse

    Rivera, Samuel; Kershner, Jeffrey L.; Keller, Gordon R.

    2009-01-01

    Testing road surface treatments to reduce erosion in forest roads in Honduras. Cien. Inv. Agr. 36(3):425-432. Using forest roads produces more erosion and sedimentation than any other forest or agricultural activity. This study evaluated soil losses from a forest road in central Honduras over two consecutive years. We divided a 400-m segment of road into 8 experimental units, each 50 m in length. Four units were treated with Best Management Practices (BMPs) and four were left untreated. The BMP treatments included reshaping the road prism, installing culverts and reshaping of road ditches, compacting 20-cm layers of the road tread, crowning the road surface (3% slope, double drainage), longitudinal sloping (less than 12%), and adding a 10-cm layer of gravel (crush size = 0.63 cm). Soil movement was measured daily during the rainy seasons. The highest soil loss occurred in the control road, around 500 m3 km-1 per year, while the road treated with BMP lost approximately 225 m3km-1 per year. These results show that road surface erosion can be reduced up to 50% with the implementation of surface treatments.

  9. Evaluación económica de rituximab en combinación con fludarabina y ciclofosfamida en comparación con fludarabina y ciclofosfamida en el tratamiento de la leucemia linfática crónica

    Microsoft Academic Search

    Luis Felipe Casado; José Antonio García Marco; Florinda Gilsanz; Marcos González; Eduardo Ríos; Javier de la Serna; Álvaro Urbano; Vicente Vicente; Carlos Rubio-Terrés; Antonio J. Castro

    2011-01-01

    ObjectivesWe evaluated the cost-effectiveness of rituximab added to the chemotherapy regimen of fludarabine plus cyclophosphamide (R-FC) versus fludarabine plus cyclophosphamide (FC) for the treatment of patients with previously untreated or relapsed\\/refractory chronic lymphocytic leukemia (CLL).

  10. Sistema de aspiración-tracción en el tratamiento de la Fasciitis necrotizante del periné * Negative Pressure wound therapy for the treatment of perineal necrotizing fasciitis

    Microsoft Academic Search

    BLAZENKO PUJADO; E. U. MARILDE; E. U. KARINA; PAULA VIDAL

    Introduction: We discuss five patients treated at our institution. Besides the initial surgical debridement and antibiotic therapy, we used the negative-pressure wound therapy (NPWT) as part of their treatment. Patients and methods: The NPWT device was constructed with off-the-shelf components. After the diagnosis of perineal necrotizing fasciitis was established, all patients underwent surgical debridement of necrotic tissue. The wound was

  11. Patología postquirúrgica del cáncer de mama. Propuesta de subproceso y desarrollo de una unidad de tratamiento rehabilitador en el contexto sanitario andaluz

    Microsoft Academic Search

    A. Galván; Y. Pons; C. Echevarría; T. Ibáñez

    2008-01-01

    In recent years, the Public Health Care Administration of Andalusia has developed health care programs to improve care programs aimed at structuring, improving and encouraging user care\\/patient care in specific diseases due to their social and economic incidence, repercussions and costs. The role of the specialist in Physical Medicine and Rehabilitation is not always well defined within the care algorithms

  12. XII SIMPOSIO DE TRATAMIENTO DE SE ~NALES, IM AGENES Y VISI ON ARTIFICIAL. STSIVA 2007 1 On Selecting Middle-Length Feature Lines for

    E-print Network

    Duin, Robert P.W.

    of Engineering and Archi- tecture, National University of Colombia at Manizales, Kil´ometro 7 V´ia al Aeropuerto, Campus La Nubia - Bloque Q, piso 2, Manizales (Caldas), Colombia. See http://www.docentes.unal.edu.co/morozcoa/ or http://orozco.co.nr/ for contact details. Robert P. W. Duin is with the Information and Communication

  13. Fundamentos del rechazo a la transfusión sanguínea por los Testigos de Jehová. Aspectos ético-legales y consideraciones anestésicas en su tratamiento

    Microsoft Academic Search

    A. Pérez Ferrer; E. Gredilla; J. de Vicente; J. García Fernández; F. Reinoso Barbero

    Summary The refusal of Jehovah's Witnesses to agree to blood or blood product transfusion based on religious beliefs is one of the most challenging conflictive issues health care givers have to face today. Such conflict is a by product of the ideological and religious diversity in society today. The perioperative care of such patients constitutes a genuine challenge for anesthesiologists

  14. 12. Laboratoris de recerca 12.1. Laboratori de Conducta i Sistemes Dinmics (LabCSD)

    E-print Network

    Oro, Daniel

    tratamiento del trastorno por déficit de atención e hiperactividad frente a los tratamientos estándar-12711) -- Desarrollo y validación de un programa de e-terapia inteligente para el tratamiento del trastorno de ansiedad

  15. Follow-up study in a patient with Setleis syndrome.

    PubMed

    Tsukahara, M; Okabe, T; Ohtsuka, M; Furukawa, S

    1995-07-01

    We report on an 8-year-old Japanese boy with Setleis syndrome. The patient had a very characteristic "coarse" facial appearance, bitemporal "forceps marks," skin aplasia, sparse hair, and skin hypo- and hyperpigmentation. He also had previously undescribed manifestations, including an aberrant hair pattern of the forehead, linear skin lesions on the forehead, short palpebral fissures, a small skin tag on the right cheek, cone-shaped teeth, and pectus carinatum. Dermatoglyphic studies documented aberrant distal palmar creases (simian crease variant), 8 arches, and reduced total finger ridge count. When serial photographs were reviewed, his facial characteristics became more obvious with increasing age. PMID:7677148

  16. Pulmonary non-tuberculous mycobacterial infection in congenital contractural arachnodactyly.

    PubMed

    Paulson, M L; Olivier, K N; Holland, S M

    2012-04-01

    Congenital contractural arachnodactyly (CCA) is caused by mutations within the fibrillin-2 gene (FBN2), which is crucial for microfibril structure. Affected individuals may have contractures, chest wall deformities, scoliosis, abnormal ear folding and elongated limbs. We describe a novel FBN2 mutation in a woman with CCA who also had pulmonary non-tuberculous mycobacteria (NTM) infection. The population with pulmonary NTM infections shares phenotypic features with CCA, such as elongated body habitus, scoliosis and pectus deformities. While it is unlikely that FBN2 defects account for susceptibility to NTM infection in the majority of cases, the overlap between these two diseases suggests some shared pathophysiology. PMID:22325249

  17. Late Holocene benthic foraminifera and paleoenvironments of the Louisiana coast

    SciTech Connect

    Eger, M.A.; Sen Gupta, B.K.

    1985-01-01

    The foraminiferal assemblages of 5 vibracores from Isles Dernieres on the Louisiana coast indicate significant environmental shifts within the past 1000 years. The cores, 2 offshore and 3 from the back barrier region, represent mainly the progradational phase of the Early Lafourche delta. Overall, Ammonia parkinsoniana and Elphidium excavatum dominate the faunas, except those of marshes and low-salinity interdistributary bays. However, a cluster analysis of species frequencies demonstrate that 5 past environments can be distinguished on the basis of some minor constituents of the assemblages. In both offshore cores, Elphidium poeyanum, Buliminella morgani, and Quinqueloculina seminulum are common in the basal, prodelta part; a reducing environment is indicated by pyrite-filled tests. A low-diversity transition zone above this is characterized by a 85-90% dominance of Ammonia parkinsoniana and Elphidium excavatum. Two delta front environments are represented in the top part of these cores. Elphidium discoidale, E. galvestonense, Hanzawaia concentrica, and Ammontium salsum are common in both, but the species diversity is lower in the upper, shallow-water facies. Marsh and low-salinity interdistributary bay facies, represented in the onshore cores, are characterized by the dominance of agglutinated species. The facies changes in the onshore cores are more complex and represent shorter time spans than in the offshore cores.

  18. Problemas sexuales y de fecundidad (hombres)

    Cancer.gov

    Muchos tratamientos del cáncer y algunos tipos de cáncer pueden causar efectos secundarios relacionados con la sexualidad y con la fecundidad. Ya sea que usted tenga o no estos problemas depende del tipo de tratamiento que recibe, de su edad al tiempo del tratamiento y del tiempo que ha pasado desde el tratamiento.

  19. Influence of postharvest hot-dip fungicide treatments on Redblush grapefruit quality during long-term storage\\/Efecto de los tratamientos fungicidas postcosecha por inmersión en agua caliente sobre la calidad del pomelo Redblush durante el almacenamiento en frío

    Microsoft Academic Search

    M. Schirra; M. Mulas; L. Baghino

    1995-01-01

    The efficacy of postharvest hot-dip treatment on Redblush grapefruit was investigated by 3-min dips in water at 50°C and 20°C, with and without 1500 ppm imazalil (IMZ) or thiabendazole (TBZ). Fruits were stored for 16 weeks in cold rooms at 8°C and then held at 20°C for 1 week to simulate shelf life. IMZ and TBZ treatment at 20°C considerably

  20. Realidad Virtual: Un Aporte Real para la Evaluación y el Tratamiento de Personas con Discapacidad Intelectual1 Virtual Reality: A Real Contribution for the Evaluation and Treatment of People with Intelectual Disability

    Microsoft Academic Search

    Claudia P. Pérez-Salas

    Virtual Reality is a particular computational simulation which allows recreating real environments where the subject is able to interact and live the experience as it were in a real setting. This article presents the principal applications of this technology in the design of environments for assessment and intervention of intellectually disabled persons, focusing in the advantages of Virtual Reality for

  1. Resistencia al tratamiento de primera línea de quimioterapia en un paciente diagnosticado de linfoma de Hodgkin de predominio linfocítico nodular identificada mediante 18F-FDG PET\\/TAC: implicaciones diagnósticas y terapéuticas

    Microsoft Academic Search

    J. Banzo; M. A. Ubieto; P. Giraldo; P. Razola; E. Prats; L. Tardin; A. Santapau; A. Parra; E. F. Rambalde; J. Velilla

    Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare entity that accounts for less than 5% of the cases of Hodgkin lymphoma (HL) with morphological, immunophenotypical, genetic and clinical behavior traits different from the classic HL. In a minority of patients, the NLPHL course is complicated by a transformation to a non-Hodgkin diffuse large B-cell lymphoma (NHDLBCL) with prognostic and therapeutic

  2. NORMATIVA CONTABLE ADOPTADA EN EL TRATAMIENTO DE OPERACIONES CON INSTRUMENTOS DERIVADOS: EVIDENCIA EMPÍRICA EN EL MERCADO DE CAPITALES PORTUGUÉS ACCOUNTING STANDARDS FOR TRANSACTIONS WITH DERIVATIVE INSTRUMENTS: EMPIRICAL EVIDENCE IN THE

    Microsoft Academic Search

    KÁTIA MATOS LEMOS; LÚCIA LIMA RODRIGUES

    In a context characterized by some uncertainty about the standards that should be adopted to account for derivative instruments, it is understandable that Portuguese companies do not follow the same rules in the initial recognition and later evaluation of these instruments and that the information they provide is so heterogeneous. Thus, this study investigates how Portuguese companies report their derivative

  3. 137Cs content in the fruit bodies of various Tuber species.

    PubMed

    Lorenzelli, R; Zambonelli, A; Serra, F; Lamma, A

    1996-12-01

    In this research, the concentration of 137Cs in the fruit bodies of the Tuber species T. magnatum Pico, T. borchii Vitt., T. aestivum Vitt., and T. excavatum Vitt. collected in three different regions of Italy was determined. The values obtained have been compared to the soil concentration of 137Cs, and the transfer factor was determined. The radiocesium content of the examined fruit bodies ranged from 2.5 Bq kg(-1) to 33.3 Bq kg(-1) fresh weight; the median transfer factor values of the four species ranged between 0.06 and 0.6. Our findings indicate that the radiocesium level in truffles from these regions of Italy is generally low, and, thus, their consumption is not of radiological concern. The results may suggest certain hypotheses as to the mechanisms involved in radiocesium uptake in these fungi. PMID:8919081

  4. High-resolution foraminiferal, isotopic, and trace element records from holocene estuarine deposits of San Francisco Bay, California

    USGS Publications Warehouse

    McGann, M.

    2008-01-01

    A 3.5-m gravity core (DJ6-93SF-6) from San Francisco Bay reveals a complex paleoclimatic history of the region over the last 3870 cal YBP. A polynomial equation based on 11 AMS 14C ages provides an excellent age model for the core, and environmental proxies for water temperature and salinity are derived from various foraminiferal abundances, stable carbon and oxygen isotopes, and Mg/Ca ratios. Two foraminiferal associations were identified by Q-mode cluster analysis: a colder-water Elphidium excavatum association and the warmer-water Ammonia beccarii-Elphidium gunteri association. The E. excavatum association dominates the core for all but about 600 years out of the last four millennia. At 3870 cal YBP, water temperatures were warm (13.9??C) and freshwater inflow was reduced compared with today. From 3590 to 2860 cal YBP, temperatures dropped 0.5??C and the climate remained dry. This was followed by a period of pronounced lower ??13C values, indicating that conditions became considerably wetter from 2860 to 2170 cal YBP. During this interval, the temperature oscillated frequently, peaking at 13.9??C at 2710 cal YBP, then dropping shortly thereafter to 12.8??C at 2420 cal YBP. Freshwater inflow gradually decreased between 2170 and 1950 cal YBP with a minimal rise in temperature, then changed quickly to colder and wetter conditions at 1900 cal YBP. Drier conditions then prevailed until 1480 cal YBP with water temperatures fluctuating between 13.1??C and 13.8??C, followed by wetter climate from 1480 to 1320 cal YBP. A significant faunal shift from the E. excavatum association to the A. beccarii-E. gunteri association occurred from 1250 to 650 cal YBP, possibly due to regional warming, decreased oxygen availability, and/or a change in the phyto-plankton community. Associated with this change in faunal composition were warm and dry conditions, representative of the Medieval Warm Period (Medieval Climatic Anomaly). A climatic shift coincident with the onset of the Little Ice Age (LIA I and LIA II) is evident from 650 to 280 cal YBP, with the return of the E. excavatum association and an extreme drop in ??18O values, all indicating increased precipitation and fresh water inflow. This was followed by generally drier conditions to the present, except for a brief wet period around 100 cal YBP, and fairly consistent water temperatures in the middle 13??C, except for a drop to 12.8??C at 200 cal YBP. Two significant faunal changes occur near the top of the core. First, there is the reappearance of the A. beccarii-E. gunteri association, suggesting that, once again, regional warming has taken place, oxygen availability has declined, and/or environmental conditions changed such that diatoms have become a scarce food source. Second, there is the first appearance of the invasive Japanese foraminifera Trochammina hadai Uchio, a species that commonly lives in highly polluted areas and is an indicator of eutrophication in its native estuaries. At the same time, freshwater inflow decreased, which may be explained by global warming during the last 100 years, or more likely due to modern water diversion for agriculture in the central valley of California. ADDITIONAL INDEX WORDS: Climate, San Francisco Bay, Holocene, foraminifers, isotopes, trace metals, Medieval Warm Period, Little Ice Age.

  5. Cohen syndrome resulting from a novel large intragenic COH1 deletion segregating in an isolated Greek island population.

    PubMed

    Bugiani, Marianna; Gyftodimou, Yolanda; Tsimpouka, Paraskevi; Lamantea, Eleonora; Katzaki, Eleni; d'Adamo, Pio; Nakou, Sheena; Georgoudi, Nelli; Grigoriadou, Maria; Tsina, Efthymia; Kabolis, Nikolaos; Milani, Donatella; Pandelia, Efthimia; Kokotas, Haris; Gasparini, Paolo; Giannoulia-Karantana, Aglaia; Renieri, Alessandra; Zeviani, Massimo; Petersen, Michael B

    2008-09-01

    Cohen syndrome, caused by mutations in the COH1 gene, is an autosomal recessive disorder consisting of mental retardation, microcephaly, growth delay, severe myopia, progressive chorioretinal dystrophy, facial anomalies, slender limbs with narrow hands and feet, tapered fingers, short stature, kyphosis and/or scoliosis, pectus carinatum, joint hypermobility, pes calcaneovalgus, and, variably, truncal obesity. Here, we describe the clinical and molecular findings in 14 patients from an isolated Greek island population. The clinical phenotype was fairly homogeneous, although microcephaly was not constant, and some patients had severe visual disability. All patients were homozygous for a novel intragenic COH1 deletion spanning exon 6 to exon 16, suggesting a founder effect. The discovery of this mutation has made carrier detection and prenatal diagnosis possible in this population. PMID:18655112

  6. A novel FBN2 mutation in a Chinese family with congenital contractural arachnodactyly.

    PubMed

    Liu, Wei; Zhao, Ning; Li, Xue-Fu; Wang, Hong; Sui, Yu; Lu, Yong-Ping; Feng, Wen-Hua; Ma, Chao; Han, Wei-Tian; Jiang, Miao

    2015-01-01

    Congenital contractural arachnodactyly (CCA, OMIM: 121050) is an autosomal dominant condition that shares skeletal features with Marfan syndrome (MFS, OMIM: 154700), including contractures, arachnodactyly, dolichostenomelia, scoliosis, crumpled ears and pectus deformities but excluding the ocular and cardiovascular complications that characterize MFS. These two similar syndromes result from mutations in two genes belonging to the fibrillin family, FBN1 and FBN2, respectively. We successfully identified a novel FBN2 mutation (C1406R) in a Chinese family with CCA for over five generations. This mutation was detected in the patients of this family but not in the seven unaffected family members or 100 normal individuals. SIFT and PolyPhen analyses suggested that the mutation was pathogenic. We identified a missense mutation in the calcium binding-epidermal growth factor (cbEGF)-like domain. Our study extends the mutation spectrum of CCA and confirms a relationship between mutations in the FBN2 gene and the clinical findings of CCA. PMID:25834781

  7. Distribution of foraminifera in Pamlico Sound, North Carolina, over the past century

    USGS Publications Warehouse

    Abbene, I.J.; Culver, S.J.; Corbett, D.R.; Buzas, M.A.; Tully, L.S.

    2006-01-01

    Foraminiferal and radionuclide data have been used to investigate environmental change that has occurred within Pamlico Sound, North Carolina, over the last century. Environmental conditions were evaluated for three time slices; (1) the modern environment as determined by surficial (0-1 cm) sediments, (2) short-core intervals representing approximately 40 years BP, as determined by 137Cs activity, and (3) short-core intervals representing approximately 120 years BP, as determined by 210Pb activity. Cluster analysis distinguished four foraminiferal assemblages at the surface (0-1 cm): (1) Marsh Biofacies, (2) Estuarine Biofacies A, (3) Estuarine Biofacies B, and (4) Marine Biofacies. The Marsh Biofacies is characterized by typical marsh foraminifera such as Tiphotrocha comprimata, Trochammina inflata, Miliammina fusca and Haplophragmoides wilberti. Estuarine Biofacies A is distinguished from Estuarine Biofacies B by the greater relative abundance of the agglutinated species Ammotium salsum and Ammobaculites crassus in the former and the greater relative abundance of Elphidium excavatum in the latter. The Marine Biofacies is comprised completely of calcareous foraminifera (e.g., Elphidium excavatum, Hanzawaia strattoni, Cibicides lobatulus, Elphidium subarcticum, Quinqueloculina seminula and Elphidium galvestonense) and is restricted to tidal inlets. Down-core foraminiferal data indicate that approximately 120 years BP, Pamlico Sound was dominated by Estuarine Biofacies A, which is indicative of brackish conditions. Upcore in the 40 years BP and modern time slices, Estuarine Biofacies B is the more prominent assemblage within Pamlico Sound; this is indicative of increased salinity over time. Lowered salinity conditions 120 years BP may be the result of high hurricane activity over a several year period.

  8. 100 Years of benthic foraminiferal history on the inner Texas shelf inferred from fauna and stable isotopes: Preliminary results from two cores

    NASA Astrophysics Data System (ADS)

    Strauss, Josiah; Grossman, Ethan L.; Carlin, Joseph A.; Dellapenna, Timothy M.

    2012-04-01

    Coastal regions, such as the Texas-Louisiana shelf, are subject to seasonal hypoxia that strongly depends on the magnitude of freshwater discharge from local and regional river systems. We have determined benthic foraminiferal fauna and isotopic compositions in two 210Pb dated box cores (BR4 and BR5) to examine the evidence for nearshore hypoxia and freshwater discharge on the Texas shelf during the last 100 years. The 210Pb chronologies of both cores reveal sedimentation rates of 0.2 and 0.1 cm yr-1, translating to ˜60 and ˜90 year records. The fauna of both cores were almost exclusively composed of Ammonia parkinsoniana and Elphidium excavatum, indicating euryhaline ambient waters. The Ammonia-Elphidium (A-E) index, a qualitative measure of low oxygen conditions, shows an increase from values between 20 and 50 to near 100 in both cores, suggesting low oxygen conditions between 1960 and the core top. Between 1950 and 1960 (9-10 cm), low A-E values in BR4 coincide with high ?18O and ?13C values greater than 0‰ and -1‰ respectively. This event corresponds to severe drought (the Texas Drought of Record) over the Brazos River drainage basin and considerably reduced river discharge from 1948 to 1957. High A-E values prior to this event imply low-oxygen conditions were prevalent prior to anthropogenic exacerbation of Louisiana shelf hypoxia and at least since the dredging of a new Brazos River delta in 1929. Elphidium excavatum ?13C values are very low (-4‰) and indicative of significant vital effect. The ?13C values of A. parkinsoniana average -3‰ and exhibit little variability, most likely reflecting pore waters influenced by aerobic and anaerobic respiration. The association of lowered Brazos River discharge with more oxygenated shelf bottom waters suggests Brazos River discharge and shelf hypoxia are linked, but the influence of Mississippi-Atchafalaya discharge can also contribute to shelf stratification.

  9. Radioterapia

    Cancer.gov

    La radioterapia es un tratamiento del cáncer que usa altas dosis de radiación para destruir células cancerosas y reducir tumores. Aprenda los diferentes tipos de radiación y lo que usted puede esperar del tratamiento.

  10. Prurito –para profesionales de salud (PDQ®)

    Cancer.gov

    Resumen de información revisada por expertos acerca del prurito (picazón de la piel) como complicación a causa del cáncer y su tratamiento. Se discuten los enfoques del manejo y tratamiento del prurito.

  11. Dolor–para profesionales de salud (PDQ®)

    Cancer.gov

    Resumen de información revisada por expertos acerca del dolor como una complicación a causa del cáncer o su tratamiento. Se discuten enfoques sobre el manejo y tratamiento del dolor relacionado con el cáncer.

  12. Platiquemos un rato...

    Cancer.gov

    1 La historia de Ana Y cómo ella recibió tratamiento para el cáncer 2 Ana tiene cáncer. 3 “Existen muchos tratamientos para el cáncer”, dijo su médico. 4 Le dio un folleto acerca de un estudio clínico, una opción para el tratamiento del cáncer. 5 Un estudio

  13. Benthic Foraminifera in the Changing Ecosystem of Long Island Sound

    NASA Astrophysics Data System (ADS)

    Thaler, B.; Thomas, E.; Varekamp, J. C.

    2004-05-01

    Long Island Sound (LIS) is an estuary in a heavily urbanized region; Long Island lies to its South, New York City (NYC) to its West and Connecticut to its North. The Connecticut River contributes >70% of the fresh water influx. LIS has a narrow opening to the West (into East River), but exchange with the ocean occurs dominantly at its eastern end, resulting in an east-west gradient in salinity. An east-west gradient is also present in indicators of anthropogenic contamination in the surface sediments (e.g., trace metals) because western LIS is close to the major source of anthropogenic input (NYC). In addition, bottom currents focus fine-grained, contaminant-loaded sediments there. Since the early 1970's western LIS and parts of central LIS have suffered summer hypoxia, probably as a result of increased algal growth caused by anthropogenic nitrogen input. Benthic foraminifera are eukaryote heterotrophic organisms with a calcareous or agglutinated test. We investigated changes in their populations over time in about 2m-long gravity cores in westernmost (WLIS75GGC1; 73o 40'W, 40o 52'N, 19m waterdepth) and coastal central LIS (B1GGC1; 73o 4'W, 41o 10'N, 8m water depth), to document environmental changes over the last millennium, including the time of European settlement and the industrial revolution and population increase. An age model was derived from metal pollution records and 14C dating. Before European settlement, the low-diversity benthic faunas in core B1GGC1, at a depth within the zone of light penetration, were dominated by Elphidium excavatum, a species feeding on living diatoms. In western LIS (below the zone of light penetration) this species was less abundant and Elphidium incertum and Buccella frigida were common. In both cores, the absolute abundance of benthic foraminifera and the relative abundance of Elphidium excavatum increased in the early 1800's, coinciding with a time of rapid increase in human population around LIS and slightly before an increase in trace metal concentration. The ecological changes may have been caused by increased productivity of diatoms resulting from beginning anthropogenic eutrophication. From the middle 1960's on, absolute foraminiferal abundance decreased and Ammonia beccarii, formerly absent or rare, became common to dominant in WLIS75GGC1; in B1GGC1 a similar but less severe change started in the 1970's. The increase in relative abundance of A. beccarii could have been caused by hypoxia (possibly in conjunction with rising bottom water temperatures), but both Ammonia and Elphidium species survive hypoxia in the laboratory. We suggest that high N/Si resulting from strong eutrophication might favor primary producers other than diatoms (e.g., dinoflagellates, cyanobacteria), making E. excavatum less competitive. The LIS coastal ecosystem thus changed significantly with the enhanced nutrient input associated with human population growth in the middle 1800's, and again with more severe eutrophication over the last few decades.

  14. TRATAMIENTOS CON ACIDO ACÉTICO DE CULTIVOS DE E. COLI Y SALMONELLA IN-VITRO Y EN LÍQUIDOS ESCURRIDOS DEL LAVADO DE CANALES DE POLLO TREATMENTS OF ACETIC ACID FOR E. COLI AND SALMONELLA IN-VITRO AND IN RUN-OFF FLUIDS FROM POULTRY WASHES

    Microsoft Academic Search

    S. M. Jiménez; M. C. Tiburzi; M. S. Salsi; M. A. Moguilevsky; M. E. Pirovani

    2008-01-01

    Studies to evaluate the in-vitro effectiveness of acetic acid against Escherichia coli and Salmonella Hadar affected by acid concentration and temperature were carried out. In a processing model system, the run-off fluids from washes of chicken carcasses experimentally contaminated with Salmonella, was also assessed. In-vitro reductions were compared with reductions predicted by models on inoculated chicken skin, as well. In-vitro

  15. Tratamento conservador da fratura toracolombar do tipo explosão: análise radiográfica da cifose pós-traumática Conservative treatment of thoracolumbar burst fractures: radiographic analysis of post-traumatic kyphosis Tratamiento conservador de la fractura toracolumbar del tipo explosión: análisis radiográfico de la cifosis postraumática

    Microsoft Academic Search

    Osmar Avanzi; Elcio Landim; Robert Meves; Maria Fernanda Silber Caffaro; Ricardo Shigueaki Umeta; Cristovam Miguel Neto

    Introduction: the post-traumatic kyphosis is a complication reported after conservative treatment of thoracolumbar burst fracture. The majority of the series evaluates all subtypes of Magerl and discuss their findings based on the average loss of kyphosis during the follow-up. Objective: evaluation of radiographic outcomes regarding kyphosis in patients with fractures subtype A3 of Magerl according to the average variation between

  16. TELEMAC : AN INTEGRATED SYSTEM TO REMOTELY MONITOR AND CONTROL ANAEROBIC WASTEWATER TREATMENT PLANTS THROUGH THE INTERNET TELEMAC: UN SISTEMA INTEGRADO PARA LA MONITORIZACION Y CONTROL DE DIGESTORES ANAEROBIOS PARA EL TRATAMIENTO DE AGUAS RESIDUALES A TRAVEZ DE INTERNET TELEMAC : UN SYSTEME INTEGRE POUR SURVEILLER ET PILOTER VIA INTERNET DES PROCEDES DE DEPOLLUTION PAR FERMENTATION ANAEROBIE

    Microsoft Academic Search

    O. Bernard; B. Chahuat; A. Hélias; B. Le Dantec; J.-P. Steyer; L. Lardon; P. Neveu

    The TELEMAC project brings new methodologies issued from the Information and Science Technologies field to the world of water treatment. TELEMAC proposes an advanced remote management system which adapts to most anaerobic wastewater treatment plants that do not benefit from a local expert in wastewater treatment. The TELEMAC system takes advantage of new sensors to automatically stabilise the treatment plant,

  17. How many entities exist for the spectrum of disorders associated with brachydactyly, syndactyly, short stature, microcephaly, and intellectual disability?

    PubMed

    Ravel, Aimé; Chouery, Eliane; Stora, Samantha; Jalkh, Nadine; Villard, Laurent; Temtamy, Samia; Mégarbané, André

    2011-04-01

    We describe a French young man with digital anomalies consisting of brachydactyly, F1-5 bilateral camptodactyly, interdigital webbing, F5 bilateral radial clinodactyly, and partial syndactyly of some fingers and toes. He had psychomotor retardation, short stature, umbilical hernia, a secundum atrial septal defect, seizures, hearing impairment, and dysmorphic features consisting of microcephaly, a prominent metopic ridge, upslanting palpebral fissures, synophrys, enophthalmia, large ears, a bulbous nose, a high palate, a smooth and short philtrum, a low hanging columella, a thin upper vermillion, an everted lower lip, prognathism, pectum excavatum, and supernumerary nipples. Osteotendinous reflexes were brisk. Mild nystagmus, myopia, and astigmatia were also noted. Total body X-rays showed short terminal phalanges of the hands, short middle phalanges of the index and little fingers, clinodactyly of the little fingers, short and fused proximal 4th and 5th metacarpals of the right hand, a short 5th metacarpal of the left hand, a fused left lunate-triquetrum, fused capitate-hamates, a prominent mandibula, and partial sacral agenesis. A thin posterior corpus callosum was apparent by MRI. Differential diagnoses for mainly the Rubinstein-Taybi syndrome, the Tsukahara syndrome, the Filippi syndrome, the Feingold syndrome, and the Tonoki syndrome are discussed, and the possibility that we might be reporting a novel entity is raised. © 2011 Wiley-Liss, Inc. PMID:21416592

  18. Selection of a set of specific primers for the identification of Tuber rufum: a truffle species with high genetic variability.

    PubMed

    Iotti, Mirco; Amicucci, Antonella; Bonito, Gregory; Bonuso, Enrico; Stocchi, Vilberto; Zambonelli, Alessandra

    2007-12-01

    Tuber rufum is a truffle widely distributed throughout Europe, which forms mycorrhizal associations with numerous species of broadleaf and coniferous trees. The possibility of T. rufum contamination in commercial truffle-infected plants makes its detection important. To facilitate the identification of T. rufum from mycorrhiza and fruitbodies, species-specific primers were designed and tested. To overcome the high intraspecific genetic variability within the internal transcribed spacer (ITS) regions of T. rufum, as demonstrated by phylogenetic analysis, two forward primers, Ru1f and Ru2f, located on the ITS1 region were designed to be used in concert with the reverse primer ITS4. Only T. rufum was amplified with this primer combination, while DNA of Tuber magnatum, Tuber brumale, Tuber maculatum, Tuber borchii, Tuber excavatum and Tuber melanosporum was not. These primers give a specific amplicon ranging between 566 and 572 bp and are able to discriminate between T. rufum, T. borchii and T. magnatum in multiplex PCR. In addition, T. rufum-specific amplicons were obtained from both spore suspensions and mycorrhiza by direct PCR. Tuber rufum mycorrhiza obtained in the greenhouse using mycelial inoculation techniques had morphological features similar to those of other species of Tuber, stressing the importance of molecular tools for their identification. PMID:18031344

  19. Benthic foraminifers on the continental shelf and upper slope, Russian River area, northern California ( USA).

    USGS Publications Warehouse

    Quinterno, P.J.; Gardner, J.V.

    1987-01-01

    We analyzed benthic foraminifers from 71 surface samples collected from the sea floor of the continental margin. One hundred and six different taxa were identified, and Q-mode factor analysis was used to identify assemblages. Six foraminiferal assemblage factors explain 94% of the variation in the data matrix. The Inner Shelf Assemblage is characterized by Trichohyalus ornatissima, Rotalia columbiensis, Cassidulina limbata, Cibicides fletcheri, Elphidiella hannai and Elphidium sp. 1 and occupies water depths less than 50 m. The Middle Shelf Assemblage is characterized by Nonionella basispinata, Elphidium excavatum and Florilus labradoricus and occupies water depths between 50 and 90 m. A Middle Shelf to Upper Bathyal Assemblage is characterized by Uvigerina juncea, Globobulimina spp. and Nonionella basispinata and occupies depths between about 90 and 450 m. Two overlapping assemblages make up the Upper Middle Bathyal Assemblage and are most abundant between water depths of 500 and 1300 m. They are associated with low- oxygen conditions. The Mid-Bathyal Assemblage is dominated by Uvigerina proboscidea and occurs on the slope at water depths ranging from 1200 to 2500 m. -from Authors

  20. Foraminiferal biofacies analysis of the Yakataga Formation, Icy Bay, Alaska: Insights into Pliocene glaciomarine paleoenvironments of the Gulf of Alaska

    SciTech Connect

    Zellers, S.D. (Univ. of Texas, Austin (USA))

    1990-06-01

    The Upper Miocene to Pleistocene Yakataga Formation of the Gulf of Alaska provides a 5 km thick record of episodic glacially-influenced marine sedimentation. The Pliocene Yakataga Fm. is exposed along western Icy Bay and records the return of glaciomarine deposition in the Gulf of Alaska, after the initiation of glaciation in the Late Miocene, and the onset of major northern hemisphere glaciation by the Late Pliocene. Analysis of foraminifera found in the Yakataga Fm. provides the basis for the interpretation of paleobathymetry and depositional environments from these rocks. Quantitative analysis is used to define eight paleoenvironmentally significant biofacies: (1) Elphidium excavatum clavatum biofacies (inner neritic), (2) Haplophragmoides spp. biofacies (outer neritic--mudline), (3) Cassidulina cf. C. teretis biofacies (outer neritic), (4) Uvigerina juncea biofacies (uppermost bathyal), (5) Elphidiella hannai biofacies (innermost neritic), (6) Epistominella pacifica biofacies (upper bathyal), (7) Cassidulina cf. C. limbata biofacies (outer neritic), (8) Nonionella miocenica biofacies (outer neritic). Paleobathymetric zones defined by these biofacies, which are constrained by modern Gulf of Alaska faunal relationships, indicate bathymetric fluctuations on the order of 100 m in the Icy Bay section. Mixing of biofacies due to downslope transport is common. Analyses of paleobathymetry, benthic formaminiferal biofacies, and sedimentology are used to interpret depositional environments ranging from innermost neritic to upper bathyal for these rocks.

  1. Proteolytic enzyme activity and attenuation of virulence in Theileria annulata schizont-infected cells.

    PubMed

    Shkap, Varda; Pipano, E; Rasulov, I; Azimov, D; Savitsky, I; Fish, L; Krigel, Y; Leibovitch, B

    2003-07-29

    A field isolate of Theileria annulata (Uzbek strain) was obtained from calves infected by Hyalomma anatolicum ticks collected from an endemic region in Uzbekistan. Schizont-infected bovine cells that had been established and propagated in cell culture were examined for attenuation both in vivo, by inoculating cells from various passages into calves, and in vitro for metalloproteinase activity. During serial subcultivation a gradual reduction in virulence and in enzyme activity in cells infected with the Uzbek strain were observed. Complete attenuation of the Uzbek isolate was obtained at about passage 80, and only traces of proteolysis were detected in gelatin substrate gels. In contrast, there was no direct correlation between virulence and enzyme levels in an Israeli strain. While schizonts of the Israeli strain were completely attenuated at passage 80, proteolysis in the substrate gels was detected up to passage 197. Solid immunity was observed in calves immunized with attenuated T. annulata schizonts of the Uzbek strain upon challenge with the homologous H. excavatum sporozoites. For a strain to be used for vaccine production, it appears that animal inoculation still remains the most reliable method to assess the degree of attenuation and protection. PMID:12935740

  2. First Molecular Identification and Genetic Characterization of Theileria lestoquardi in Sheep of the Maghreb Region.

    PubMed

    Rjeibi, M R; Darghouth, M A; Rekik, M; Amor, B; Sassi, L; Gharbi, M

    2014-09-11

    Theileria lestoquardi is the most prominent Theileria species in small ruminants that causes malignant theileriosis of sheep in Africa and Asia. In the present survey, blood samples and ticks were collected in Kebili (southern Tunisia) from 166 Queue Fine de l'Ouest sheep. Giemsa-stained blood smears, immunofluorescent antibody test (IFAT) and PCR were performed. The DNA was extracted from blood and analysed by PCR targeting 18S rRNA gene of Theileria spp. and then sequenced. A total number of 140 ticks were collected from a total number of 166 sheep during the four seasons. The ticks belonged to two genera and 4 species; the most frequent tick was Hyalomma excavatum 84.3% (118/140) and then Rhipicephalus spp. 15.7% (22/140). Only two animals had positive Giemsa-stained blood smears, and they were also positive by IFAT. The amplicons had 99.3 and 99.6% homology with the BLAST published T. lestoquardi amplicons. To our knowledge, this is the first report of T. lestoquardi in small ruminants within the Maghreb region. PMID:25208526

  3. Prevalence and genetic diversity of piroplasm species in horses and ticks from Tunisia.

    PubMed

    Ros-García, Amaia; M'ghirbi, Youmna; Hurtado, Ana; Bouattour, Ali

    2013-07-01

    The genetic diversity and prevalence of Babesia and Theileria species in the equine population of Tunisia were studied using reverse line blot (RLB) hybridization on blood samples and unfed adult ticks collected from apparently healthy horses from three bioclimatic zones in Tunisia. Piroplasms were identified in 13 of 104 of the horse blood samples analyzed (12.5%) and five genotype groups were identified: Theileria equi group A (nine animals, 8.7%), group C (one animal, 1.0%) and group D (three animals, 2.9%), and Babesia caballi groups A and B (one animal each). All horses from the semi-arid zone were negative and prevalence in the humid and sub-humid zones were 12.9% and 20.0%, respectively. Three Ixodid tick species (Hyalomma marginatum, Hyalomma excavatum and Rhipicephalus bursa) were collected from examined horses and equine piroplasms were detected in 10.8% of them. T. equi groups A and D (9.2%), and B. caballi group B (1.6%) were identified in ticks. This work represents the first epidemiological report of equine piroplasmosis in Tunisia. Results showed a high level of diversity within the 18S rRNA gene of equine piroplasm species, and confirmed the presence in Tunisia of two T. equi genetic groups, C and D, only reported before in South Africa and Sudan. PMID:23542456

  4. Improved resolution of major clades within Tuber and taxonomy of species within the Tuber gibbosum complex.

    PubMed

    Bonito, Gregory; Trappe, James M; Rawlinson, Pat; Vilgalys, Rytas

    2010-01-01

    Tuber gibbosum Harkn., described from northern California, originally was thought to be a single, variable species that fruited from autumn through winter to spring. It has become popular as a culinary truffle in northwestern USA, where it is commercially harvested. Morphological studies suggested it might be a complex that includes at least two species. We conducted morphological and phylogenetic studies of the complex to determine how many species it might contain and how they differed morphologically, geographically and seasonally. We also provide the first LSU phylogeny for the genus Tuber. Phylogenetic analyses resolve nine major clades in the genus with high bootstrap support and distinguish the Gibbosum clade from the Aestivum, Excavatum, Macrosporum, Magnatum, Melanosporum, Puberulum, Rufum and Spinoreticulatum clades. Further analyses of ITS and LSU regions revealed four distinct species in the Gibbosum complex. Although morphologically similar the four species differ in spore size and shape and in peridial anatomy. These species share the synapomorphy of having suprapellis hyphae with distinctive, irregular wall swellings at maturity; we have not seen this hyphal type in any other Tuber spp. worldwide. The three new species are named and described as T. bellisporum Bonito & Trappe, T. castellanoi Bonito & Trappe and T. oregonense Trappe, Bonito & Rawlinson. PMID:20943504

  5. Late Holocene evolution and increasing pollution in Guanabara Bay, Rio de Janeiro, SE Brazil.

    PubMed

    Vilela, Claudia Gutterres; Figueira, Brígida Orioli; Macedo, Mariana Cardoso; Baptista Neto, José Antonio

    2014-02-15

    To detect changes during the Late Holocene and historical periods in Guanabara Bay, the paleoecological and ecological parameters from nine cores were analysed using foraminiferal assemblages and bioindicators. Using radiocarbon dates and sedimentation rates in the cores, it was possible to detect the first Europeans' arrival in the 16th century. Foraminiferal bioindicators of organic matter and human pollution were correlated with radiocarbon dates from the bottom and middle of the cores in each region and revealed an increase in pollution along the cores. The foraminiferal results were compared with total organic carbon (TOC) values before, during and after European settlement and showed a historical increase in organic matter. Pristine mangrove ecosystems are characterised by agglutinated species such as Ammotium salsum, and the presence of this organism also confirmed the extent of historical mangrove forests. Ammonia tepida, Buliminella elegantissima and Elphidium excavatum were the dominant species, but they presented distinct patterns over time. B. elegantissima was dominant before the European influence in older sediments with high organic matter content that were found at deeper intervals. A. tepida is dominant in younger sediments at upper intervals, as a bioindicator of human pollution. PMID:24373667

  6. Spondyloepimetaphyseal dysplasia with joint laxity (SEMDJL): clinical and radiological findings in a Guatemalan patient.

    PubMed

    Bradburn, J M; Hall, B D

    1995-11-01

    We report on a patient of Guatemalan descent whose physical and radiological findings are consistent with a diagnosis of spondyloepimetaphyseal dysplasia with joint laxity (SEMDJL). This is a rare, autosomal recessive skeletal dysplasia with short limbs, severe scoliosis, high dorsal kyphoscoliosis, and joint hypermobility. Most described patients with SEMDJL are from the Afrikaans-speaking communities of South Africa. Patients with SEMDJL have an oval face, prominent eyes, and blue sclerae. Our patient's height and weight were below the fifth centile. She had prominent eyes with blue sclerae, a narrow, high-arched palate, pectus carinatum, severe scoliosis, and hyperextensibility and instability of most joints, with limited extension and supination of her elbows. A review of her roentgenograms showed severe scoliosis, poorly developed ischial, iliac, and pubic bones, a "bat-like" appearance of the iliac bones, "dysplastic" acetabulum, minimal metaphyseal and epiphyseal abnormalities at the knees, deformation of the proximal femoral metaphyses, and generalized brachydactyly of the hands and feet. This disorder may be more common than previously thought, and the diagnosis should be considered in any child with a dwarfing condition and joint laxity. PMID:8588592

  7. Novel, Compound Heterozygous, Single-Nucleotide Variants in MARS2 Associated with Developmental Delay, Poor Growth, and Sensorineural Hearing Loss.

    PubMed

    Webb, Bryn D; Wheeler, Patricia G; Hagen, Jacob J; Cohen, Ninette; Linderman, Michael D; Diaz, George A; Naidich, Thomas P; Rodenburg, Richard J; Houten, Sander M; Schadt, Eric E

    2015-06-01

    Novel, single-nucleotide mutations were identified in the mitochondrial methionyl amino-acyl tRNA synthetase gene (MARS2) via whole exome sequencing in two affected siblings with developmental delay, poor growth, and sensorineural hearing loss.We show that compound heterozygous mutations c.550C>T:p.Gln 184* and c.424C>T:p.Arg142Trp in MARS2 lead to decreased MARS2 protein levels in patient lymphoblasts. Analysis of respiratory complex enzyme activities in patient fibroblasts revealed decreased complex I and IV activities. Immunoblotting of patient fibroblast and lymphoblast samples revealed reduced protein levels of NDUFB8 and COXII, representing complex I and IV, respectively. Additionally, overexpression of wild-type MARS2 in patient fibroblasts increased NDUFB8 and COXII protein levels. These findings suggest that recessive single-nucleotide mutations in MARS2 are causative for a new mitochondrial translation deficiency disorder with a primary phenotype including developmental delay and hypotonia. Identification of additional patients with single-nucleotide mutations in MARS2 is necessary to determine if pectus carinatum is also a consistent feature of this syndrome. PMID:25754315

  8. Phylloid pattern of pigmentary disturbance in a case of complex mosaicism.

    PubMed

    Ribeiro Noce, T; de Pina-Neto, J M; Happle, R

    2001-01-15

    Among the various types of pigmentary disturbances associated with mosaicism, the phylloid pattern (Greek phyllon = leaf, eidos = form) is characterized by multiple leaf-like patches reminiscent of an art nouveau painting. The number of cases displaying this unusual pattern is so far limited. We describe a phylloid pattern of hypomelanosis in a 3-year-old girl with multiple congenital anomalies including microcephaly, midfacial hypoplasia, cleft lip, coloboma, posteriorly rotated ears, pectus carinatum, and pronounced mental and physical retardation. In addition, this child had oval or oblong patches of hyperpigmentation involving the trunk in a horizontal arrangement dissimilar from the phylloid hypomelanotic pattern. In peripheral blood lymphocytes a karyotype 46,XX,-13,+t(13q;13q) was consistently found, whereas cultured skin fibroblasts showed a complex form of mosaicism comprising three different abnormal cell lines (46,XX,-13,+t(13q;13q)/45,XX,-13/45,XX,-13,+frag). This case provides further evidence that the phylloid pattern represents a separate category of pigmentary disturbance to be distinguished from other types of cutaneous mosaicism such as the lines of Blaschko or the checkerboard arrangement. PMID:11223850

  9. The clinical presentation of Marfan syndrome is modulated by expression of wild-type FBN1 allele.

    PubMed

    Aubart, Mélodie; Gross, Marie-Sylvie; Hanna, Nadine; Zabot, Marie-Thérèse; Sznajder, Marc; Detaint, Delphine; Gouya, Laurent; Jondeau, Guillaume; Boileau, Catherine; Stheneur, Chantal

    2015-05-15

    Marfan syndrome is an autosomal dominant disorder mainly caused by mutations within FBN1 gene. The disease displays large variability in age of onset or severity and very poor phenotype/genotype correlations have been demonstrated. We investigated the hypothesis that phenotype severity could be related to the variable expression level of fibrillin-1 (FBN1) synthesized from the wild-type (WT) allele. Quantitative reverse-transcription and polymerase chain reaction was used to evaluate FBN1 levels in skin fibroblasts from 80 Marfan patients with premature termination codons and in skin fibroblasts from 80 controls. Results in controls showed a 3.9-fold variation in FBN1 mRNA synthesis level between subjects. A similar 4.4-fold variation was found in the Marfan population, but the mean level of FBN1 mRNA was a half of the control population. Differential allelic expression analysis in Marfan fibroblasts showed that over 90% of FBN1 mRNA was transcribed from the wild allele and the mutated allele was not detected. In the control population, independently of the expression level of FBN1, we observed steady-state equilibrium between the two allelic-mRNAs suggesting that FBN1 expression mainly depends on trans-acting regulators. Finally, we show that a low level of residual WT FBN1 mRNA accounts for a high risk of ectopia lentis and pectus abnormality and tends to increase the risk of aortic dilatation. PMID:25652400

  10. Clinical Report of a 17q12 Microdeletion with Additionally Unreported Clinical Features

    PubMed Central

    Roberts, Jennifer L.; Gandomi, Stephanie K.; Parra, Melissa; Lu, Ira; Gau, Chia-Ling; Dasouki, Majed; Butler, Merlin G.

    2014-01-01

    Copy number variations involving the 17q12 region have been associated with developmental and speech delay, autism, aggression, self-injury, biting and hitting, oppositional defiance, inappropriate language, and auditory hallucinations. We present a tall-appearing 17-year-old boy with marfanoid habitus, hypermobile joints, mild scoliosis, pectus deformity, widely spaced nipples, pes cavus, autism spectrum disorder, intellectual disability, and psychiatric manifestations including physical and verbal aggression, obsessive-compulsive behaviors, and oppositional defiance. An echocardiogram showed borderline increased aortic root size. An abdominal ultrasound revealed a small pancreas, mild splenomegaly with a 1.3?cm accessory splenule, and normal kidneys and liver. A testing panel for Marfan, aneurysm, and related disorders was negative. Subsequently, a 400?K array-based comparative genomic hybridization (aCGH) + SNP analysis was performed which identified a de novo suspected pathogenic deletion on chromosome 17q12 encompassing 28 genes. Despite the limited number of cases described in the literature with 17q12 rearrangements, our proband's phenotypic features both overlap and expand on previously reported cases. Since syndrome-specific DNA sequencing studies failed to provide an explanation for this patient's unusual habitus, we postulate that this case represents an expansion of the 17q12 microdeletion phenotype. Further analysis of the deleted interval is recommended for new genotype-phenotype correlations. PMID:24991439

  11. Función neuropsicológica en la fenilcetonuria tratada precozmente: Una revisión

    Microsoft Academic Search

    Louise H. Crossley; Peter J. Anderson

    2010-01-01

    ResumenLa fenilcetonuria (FCU) es un error metabólico congénito que implica una deficiencia de la enzima fenilalanina hidroxilasa. Este proceso da lugar a niveles elevados de fenilalanina y niveles bajos de tirosina. Si no se administra tratamiento aparecen graves secuelas neuropatológicas y neuroconductuales. La puesta en práctica de la detección sistemática de recién nacidos y el tratamiento dietético precoz ha reducido

  12. El estudio NCI-MATCH vinculará medicamentos dirigidos para el cáncer con anomalías genéticas

    Cancer.gov

    Los investigadores del estudio a nivel nacional NCI-MATCH: Análisis molecular para la elección de tratamientos, anunciaron que el estudio busca determinar la eficacia de los tratamientos dirigidos en personas con tumores que presentan mutaciones genéticas específicas independientemente de su tipo de cáncer.

  13. Changes in the structure and composition of two Pinus nigra subsp. salzmannii forests over a century of different

    E-print Network

    Herrera, Carlos M.

    Changes in the structure and composition of two Pinus nigra subsp. salzmannii forests over ordenados de Pinus nigra subsp. salzmannii durante un siglo de tratamientos selvícolas diferentes Los tratamientos sel- vícolas favorecieron a Pinus nigra y no beneficiaron a otras especies. La cantidad de árboles

  14. On-Site Wastewater Treatment Systems: Operation and Maintenance (Spanish) 

    E-print Network

    Lesikar, Bruce J.; Enciso, Juan

    2000-08-15

    aguas subterr?neas. Los sistemas individuales para el tratamiento de aguas negras se pueden conseguir de muchos tipos y en muchos tama?os. Los requisitos del mantenimiento y la operaci?n de cada uno dependen de: 3 El m?todo de tratamiento utilizado para...

  15. Laboratori de Conducta i Sistemes Dinmics (LabCSD) El Laboratori de Conducta i Sistemes Dinmics (LabCSD) sorgeix de la collaboraci

    E-print Network

    Oro, Daniel

    del neurofeedback en el tratamiento del trastorno por déficit de atención e hiperactividad frente tratamiento del trastorno de ansiedad social (PSI2010-17563) · El estudio del Sluggish Cognitive Tempo (SCT) en un diseño longitudinal para mejorar la conceptualización del trastorno por déficit de atención e

  16. Los estudios clnicos y la medicina complementaria y alternativa

    E-print Network

    Baker, Chris I.

    enfermedades y trastornos. La participación en los estudios clínicos tiene riesgos y beneficios. El gobierno atención sanitaria y contribuye a la comprensión de las enfermedades y los trastornos (por ejemplo, la: Estudios sobre tratamientos someten a prueba los tratamientos para una determinada enfermedad o trastorno

  17. [First mexican consensus on recommendations of the multidisciplinary care of patients with glioblastoma multiforme (GBM): Mexican Interdisciplinary Group on Neuro-Oncology Research (GIMINO)].

    PubMed

    Celis, Miguel Ángel; Alegría-Loyola, Marco Antonio; González-Aguilar, Alberto; Martínez-Tlahuel, Jorge; Green-Renner, Dan; Reyes-Soto, Gervith; Arellano-Reynoso, Alfonso; Flores-Castro, Jesús Manuel; Moreno-Jiménez, Sergio; Poitevin-Chacón, María Adela; Cacho-Díaz, Bernardo; Olvera-Manzanilla, Eduardo; Díaz-Victoria, Ana Ruth; Aguilar-Castañeda, Erika; Granados-García, Martín; Rodríguez-Orozco, Josana; Herrera-Goepfert, Roberto; Álvarez-Avitia, Miguel Ángel

    2015-01-01

    El GBM es uno de los tumores más agresivos y con peor pronóstico del sistema nervioso central. Los tratamientos aplicados hasta el momento han logrado aumentar sensiblemente la supervivencia de estos pacientes, dependiendo de la edad, el estado cognitivo y la autonomía de los propios individuos. En función de estos parámetros se realiza tanto el tratamiento inicial como en la recurrencia, así como el seguimiento de la enfermedad mediante estudios de imagen. Una vez que el paciente entra en fase terminal y se suspenden los tratamientos curativos, se ha de garantizar el respeto a la voluntad anticipada y el desarrollo y aplicación de las terapias paliativas. PMID:26089278

  18. Benthic foraminifera record and geochemical studies to reconstruct the recent (~400 ya) paleoenvironment of Tomales Bay, California

    NASA Astrophysics Data System (ADS)

    Flores, S. C.; Hill, T. M.; Russell, A. D.; Brooks, G.

    2010-12-01

    We are conducting investigations of calcareous benthic foraminifera acquired from Tomales Bay, California to reconstruct geochemical conditions of the bay for the past ~400 years, a time period of both natural and anthropogenic environmental change. Tomales Bay, located ~50km northwest of San Francisco, is a long (20.4 km), narrow (0.7 - 1.7 km) and shallow (2.0 - 6.0 m) bay that exhibits long-residence times and is stratified in the summer due to seasonal hypersalinity. Tomales Bay is a unique environment for climate and environmental change research because of the wide documented variability in carbonate parameters (pH, alkalinity, DIC) due to freshwater input from terrestrial sources that decreases aragonite and calcite saturation states. The historical record provided by benthic foraminiferal species and geochemistry, sedimentary carbon (TOC and TIC) analyses, and investigations of recent (Rose-Bengal stained) foraminifera are being utilized to constrain 3 major processes: 1) the range of temperature and salinity shifts over the past 400 years, 2) the relative dominance of marine- vs. fresh-water sources to the bay, and 3) the extent to which freshwater input and runoff may influence water chemistry (saturation state, ?) with impacts on foraminiferal calcification. Four sediment cores were acquired in 2009 and 2010, and subsequently age-dated utilizing radiocarbon analyses (seven samples). Results indicate an increase in preservation of agglutinated versus calcareous foraminiferal tests (shells) since the mid-1900’s, and greater abundances of agglutinated tests found near freshwater sources. The major calcareous foraminifera present in the record include Elphidium hannai, Elphidium excavatum, Ammonia tepida, and Buccella frigida. Results from oxygen and carbon stable isotope analyses as well as total organic carbon (by weight) for all the cores will also be presented. These results will be compared to modern observations and instrumental records of temperature, salinity and pH variability to understand the context of historical changes compared to modern shifts due to human influence.

  19. Topical application of marine briarane-type diterpenes effectively inhibits 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and dermatitis in murine skin

    PubMed Central

    2011-01-01

    Background Skin is the largest organ in the body, and is directly exposed to extrinsic assaults. As such, the skin plays a central role in host defense and the cutaneous immune system is able to elicit specific local inflammatory and systemic immune responses against harmful stimuli. 12-O-tetradecanoylphorbol-13-acetate (TPA) can stimulate acute and chronic inflammation and tumor promotion in skin. TPA-induced dermatitis is thus a useful in vivo pharmacological platform for drug discovery. In this study, the inhibitory effect of briarane-type diterpenes (BrDs) from marine coral Briareum excavatum on TPA-induced dermatitis and dendritic cell (DC) function was explored. Methods Evans blue dye exudation was used to determine vascular permeability. H&E-stained skin section was used to determine the formation of edema in mouse abdominal skin. We also used immunohistochemistry staining and western blot assays to evaluate the activation of specific inflammation makers and key mediators of signaling pathway in the mouse skin. Furthermore, mouse bone marrow DCs were used to determine the relationship between the chemical structure of BrDs and their regulation of DC function. Results BrD1 remarkably suppressed TPA-induced vascular permeability and edema in skin. At the biochemical level, BrD1 inhibited TPA-induced expression of cyclooxygenase-2, inducible nitric oxide synthase and matrix metalloproteinase-9, the key indicators of cutaneous inflammation. This inhibition was apparently mediated by interference with the Akt/NF-?B-mediated signaling network. BrD1 also inhibited TNF-? and IL-6 expression in LPS-stimulated BMDCs. The 8, 17-epoxide of BrDs played a crucial role in the inhibition of IL-6 expression, and replacement of the C-12 hydroxyl group with longer esters in BrDs gradually decreased this inhibitory activity. Conclusions Our results suggest that BrDs warrant further investigation as natural immunomodulatory agents for control of inflammatory skin diseases. PMID:22189182

  20. The abundance of benthic calcareous Foraminifera and other meiofauna at a time series station in the Northeast Water Polynya, Greenland

    NASA Astrophysics Data System (ADS)

    Newton, Adrian C.; Rowe, Gilbert T.

    1995-03-01

    Abundance and vertical distribution of living calcareous Foraminifera and associated meiofauna have been estimated during the ice-free period in 1992 and 1993 at a time series station in the Northeast Water Polynya off eastern Greenland. Calcareous forams (>150 ?m) represented on average 28-39% of the meiofaunal size class. The mean abundance for both years was 574 individuals/100 cm2, and the variability of the estimates (Standard deviation = ±140) was relatively modest for benthic samples (Standard error=8.7% of the mean, number of samples=8). The abundance in 1992 was lower than in 1993 (probability <0.05), reflecting a smaller polynya, with less surface water productivity. While 41% of the variation in abundance in 1993 could be explained as a function of time (the estimated mean doubled between May 30 (387 ind/100 cm2) and July 24 (734 ind/100 cm2)), supporting earlier observations elsewhere that Foraminifera respond rapidly to seasonal or pulsed food inputs, the relationship was not statistically significant. The number of species present was low, a characteristic observed in other foram biofacies associated with open water shelf regions of the Arctic. This assemblage was dominated by a few calcareous forms: Elphidium excavatum, Melonis barleeanum, Nonionella labradorica, and Bucella frigida. Green and brown material, which we suspect was freshly settled phytodetritus, was found in numerous individuals of the dominant calcareous species located as deep as 6 cm within the sediment. The dominant species, including those containing "pigments," were encountered at specific, fairly narrow depth ranges within the sediment, with maximum abundances being common below, rather than at the sediment surface. Other meiofauna (nematodes, agglutinated forams, and ostracods) occurred to depths as great as 10 cm in all cores, but their greatest densities were generally confined to surface sediments.

  1. Natural history and clinical assessment of Taiwanese patients with mucopolysaccharidosis IVA

    PubMed Central

    2014-01-01

    Background Mucopolysaccharidosis IVA (MPS IVA) is a rare lysosomal storage disorder caused by N-acetylgalactosamine-6-sulfatase deficiency, which catalyzes a step in the catabolism of glycosaminoglycans, keratan sulfate and chondroitin-6-sulfate. This disease has a variable age of onset and rate of progression. Methods A retrospective analysis of medical records of 24 patients with MPS IVA (11 males, 13 females; current mean age?±?SD, 12.6?±?6.6 years; age range, 1.4-29.4 years) seen at 6 medical centers in Taiwan from January 1996 through June 2013 was performed. Results Mean ages of onset of symptoms and confirmed diagnosis were 2.0?±?1.6 and 5.7?±?4.5 years, respectively. The most prevalent clinical manifestations were kyphosis (100%), pectus carinatum (96%), abnormal gait (93%), striking short trunk dwarfism (92%), genu valgum (92%), and valvular heart disease (91%). Eight patients (33%) experienced at least one surgical procedure with the most common being ear tube insertion (25%), adenoidectomy (17%), tonsillectomy (13%), supraglottoplasty (13%), spinal decompression (13%), and spinal fusion (13%). The most prevalent cardiac valve abnormalities were aortic stenosis (45%) and mitral regurgitation (45%). At the time of the study, 8 out of 24 patients (33%) have died at the mean age of 17.2?±?7.7 years. Conclusions An understanding of the natural history involved in MPS IVA may allow early diagnosis of the disease. All affected Taiwanese patients experienced significant functional limitations. Adequate evaluations and timely management may improve clinical outcomes and quality of life. PMID:24513086

  2. A kindred exhibiting cosegregation of an overlap connective tissue disorder and the chromosome 16 linked form of autosomal dominant polycystic kidney disease.

    PubMed

    Somlo, S; Rutecki, G; Giuffra, L A; Reeders, S T; Cugino, A; Whittier, F C

    1993-12-01

    Autosomal dominant polycystic kidney disease (ADPKD) is a disorder of adult onset manifested by bilaterally enlarged cystic kidneys frequently associated with progressive renal failure. The mutated gene (PKD1) responsible for 85 to 95% of cases has been localized to a small segment on the distal tip of the short arm of chromosome 16. A clinical spectrum of heritable connective tissue disorders that remain unclassifiable under the present nosology but that contain elements of the Marfan's syndrome have previously been described. The genetic localization and molecular basis of such overlap connective tissue disorders (OCTD) have not been elucidated. In this report, a kindred in which ADPKD and OCTD appear to cosegregate is described. The connective tissue phenotype in this family includes aortic root dilation, aortic and vertebral artery aneurysms with dissection, and aortic valve incompetence, as well as pectus abnormalities, pes planus, joint laxity, arachnodactyly, scoliosis, dolichostenomelia, and high arched palate. ADPKD was manifest primarily as bilateral renal cysts with or without renal failure. The DNA of all living family members was studied with markers recognizing polymorphic loci flanking the PKD1 region (3'HVR and O90a), as well as markers from the loci of chromosomes 15 and 5, associated with fibrillin genes FBN1 and FBN2, respectively. In this kindred of 20 family members traced through five generations, cosegregation of ADPKD and the OCTD phenotype was observed in 12 of 12 meioses and 3 of 3 phase known. Both markers for PKD1 were tightly linked to both ADPKD and OCTD, whereas there was no evidence for linkage with either fibrillin locus. In this family, the ADPKD and OCTD mutations are genetically linked. The presence of OCTD with ADPKD identifies a group of patients at significantly greater risk for sudden death from aortic root and other vascular aneurysmal dissection and rupture. PMID:8130364

  3. Leucemia–para profesionales de salud

    Cancer.gov

    Información del Instituto Nacional del Cáncer para profesionales de salud sobre el tratamiento de la leucemia, así como referencias a estudios clínicos, investigación, estadísticas y otros temas relacionados con este tipo de cáncer.

  4. Neoplasias de células plasmáticas (incluso mieloma múltiple)–para profesionales de salud

    Cancer.gov

    Información del Instituto Nacional del Cáncer para profesionales de salud sobre el tratamiento del mieloma múltiple y otras neoplasias de células plasmáticas, así como referencias a estudios clínicos, investigación, estadísticas y otros temas relacionados.

  5. Tumores cerebrales–para profesionales de salud

    Cancer.gov

    Información del Instituto Nacional del Cáncer para profesionales de salud sobre el tratamiento de los tumores cerebrales, así como referencias a estudios clínicos, estadísticas y otros temas relacionados con estos tipos de cáncer.

  6. Neoplasias de células plasmáticas (incluso mieloma múltiple)

    Cancer.gov

    Información del Instituto Nacional del Cáncer sobre el tratamiento del mieloma múltiple y otras neoplasias de células plasmáticas, así como referencias a estudios clínicos, investigación, estadísticas y otros temas relacionados.

  7. Leucemia

    Cancer.gov

    Información del Instituto Nacional del Cáncer sobre el tratamiento de la leucemia, así como referencias a estudios clínicos, investigación, estadísticas y otros temas relacionados con este tipo de cáncer.

  8. Cáncer de ovario, de trompa de Falopio y primario de peritoneo–para profesionales de salud

    Cancer.gov

    Información del Instituto Nacional del Cáncer para profesionales de salud sobre el tratamiento, la prevención, la genética, las causas y los exámenes de detección del cáncer de ovario, así como referencias a estudios clínicos, investigación, estadísticas y otros temas relacionados.

  9. Cáncer de páncreas–para profesionales de salud

    Cancer.gov

    Información del Instituto Nacional del Cáncer para profesionales de salud sobre el tratamiento del cáncer de páncreas, así como referencias a estudios clínicos, investigación y otros temas relacionados con este tipo de cáncer.

  10. Lo que usted necesita saber sobre™ el cáncer de cérvix

    Cancer.gov

    Contiene información sobre las opciones de tratamiento, la obtención de una segunda opinión, los cuidados de seguimiento y las fuentes de apoyo para alguien que ha sido diagnosticado recientemente con cáncer de cérvix o cuello uterino.

  11. Cáncer de riñón –para profesionales de salud

    Cancer.gov

    Información del Instituto Nacional del Cáncer para profesionales de salud sobre el tratamiento del cáncer de riñón, así como referencias a estudios clínicos, investigación, estadísticas y otros temas relacionados con este tipo de cáncer.

  12. Tumores extracraneales de células germinativas–para profesionales de salud

    Cancer.gov

    Información del Instituto Nacional del Cáncer para profesionales de salud sobre el tratamiento del tumor extracraneal de células germinativas en los niños, así como referencias a estudios clínicos y otros temas relacionados.

  13. Cáncer de pulmón–para profesionales de salud

    Cancer.gov

    Información del Instituto Nacional del Cáncer para profesionales de salud sobre el tratamiento, la prevención, las causas y los exámenes de detección del cáncer de pulmón, así como referencias a estudios clínicos, investigación, estadísticas y otros temas relacionados.

  14. Tumores cerebrales

    Cancer.gov

    Información del Instituto Nacional del Cáncer sobre el tratamiento de los tumores cerebrales, así como referencias a estudios clínicos, estadísticas y otros temas relacionados con estos tipos de cáncer.

  15. Cáncer de cuello uterino–para profesionales de salud

    Cancer.gov

    Información del Instituto Nacional del Cáncer para profesionales de salud sobre el tratamiento, la prevención, las causas y los exámenes de detección del cáncer de cuello uterino, así como referencias a estudios clínicos, investigación, estadísticas y otros temas relacionados.

  16. Cáncer de cabeza y cuello–para profesionales de salud

    Cancer.gov

    Información del Instituto Nacional del Cáncer para profesionales de salud sobre el tratamiento, la prevención, las causas y los exámenes de detección de los cánceres de cabeza y cuello, así como referencias a estudios clínicos, investigaciones, estadísticas y temas relacionados.

  17. Tensión postraumática relacionada con el cáncer (PDQ®)

    Cancer.gov

    Resumen de información revisada por expertos acerca de la tensión postraumática y síntomas relacionados en los pacientes con cáncer, sobrevivientes del cáncer y miembros de la familia. Se discuten la evaluación y tratamiento de estos síntomas.

  18. Aspectos relacionados con la sexualidad y la reproducción –para profesionales de salud (PDQ®)

    Cancer.gov

    Resumen de información revisada por expertos acerca de los factores que pueden afectar el funcionamiento sexual de las personas con cáncer. Se discuten además temas sobre la fecundidad relacionados con el tratamiento del cáncer.

  19. Ttulos Propios de la UAM (curso acadmico 2007 / 2008) TTULOS PROPIOS DE LA UAM

    E-print Network

    Autonoma de Madrid, Universidad

    Fisioterapia Respiratoria Diploma de Formación Superior en Cuidados Paliativos y Tratamiento del Soporte del Paciente con Cáncer #12;TÍTULOS PROPIOS DE LA UAM D.F.S en Fisioterapia Osteoarticular D.F.S en

  20. Cáncer de la corteza suprarrenal

    Cancer.gov

    Información del Instituto Nacional del Cáncer sobre el tratamiento del carcinoma de corteza suprarrenal, así como referencias a estudios clínicos, investigación y otros temas relacionados con este tipo de cáncer.

  1. Cáncer de riñón

    Cancer.gov

    Información del Instituto Nacional del Cáncer sobre el tratamiento del cáncer de riñón, así como referencias a estudios clínicos, investigación, estadísticas y otros temas relacionados con este tipo de cáncer.

  2. Cáncer de útero

    Cancer.gov

    Información del Instituto Nacional del Cáncer sobre el tratamiento, la prevención, las causas y los exámenes de detección del cáncer uterino, así como referencias a estudios clínicos, investigación, estadísticas y otros temas relacionados.

  3. Cáncer de intestino delgado

    Cancer.gov

    Información del Instituto Nacional del Cáncer sobre el tratamiento del cáncer de intestino delgado, así como referencias a estudios clínicos, investigación y otros temas relacionados con este tipo de cáncer.

  4. Cáncer de hígado y de conducto biliar

    Cancer.gov

    Información del NCI sobre el tratamiento, la prevención y los exámenes de detección del cáncer de hígado y de conducto biliar, así como referencias a estudios clínicos, investigación y otros temas relacionados con este tipo de cancer.

  5. Cáncer de vejiga

    Cancer.gov

    Información del Instituto Nacional del Cáncer sobre el tratamiento, las causas y los exámenes de detección del cáncer de vejiga, así como referencias a estudios clínicos, investigación, estadísticas y otros temas relacionados con este tipo de cáncer.

  6. Cáncer de próstata

    Cancer.gov

    Información del Instituto Nacional del Cáncer sobre el tratamiento, la prevención, las causas y los exámenes de detección del cáncer de próstata, así como referencias a estudios clínicos, investigación, estadísticas y otros temas relacionados.

  7. Cáncer de vesícula biliar

    Cancer.gov

    Información del Instituto Nacional del Cáncer sobre el tratamiento del cáncer de vesícula biliar, así como referencias a estudios clínicos, investigación y otros temas relacionados con este tipo de cáncer.

  8. Cáncer de estómago

    Cancer.gov

    Información del Instituto Nacional del Cáncer sobre el tratamiento, la prevención, las causas y los exámenes de detección del cáncer de estómago (gástrico), así como referencias a estudios clínicos, investigación, estadísticas y otros temas relacionados.

  9. Cáncer de cuello uterino

    Cancer.gov

    Información del Instituto Nacional del Cáncer sobre el tratamiento, la prevención, las causas y los exámenes de detección del cáncer de cuello uterino, así como referencias a estudios clínicos, investigación, estadísticas y otros temas relacionados.

  10. Cáncer de testículo

    Cancer.gov

    Información del Instituto Nacional del Cáncer sobre el tratamiento, las causas y los exámenes de detección del cáncer de testículo, así como referencias a estudios clínicos, investigación y otros temas relacionados con este tipo de cáncer.

  11. Cáncer de ovario, de trompa de Falopio y primario de peritoneo

    Cancer.gov

    Información del Instituto Nacional del Cáncer sobre el tratamiento, la prevención, la genética, las causas y los exámenes de detección del cáncer de ovario, así como referencias a estudios clínicos, investigación, estadísticas y otros temas relacionados.

  12. Cáncer de esófago

    Cancer.gov

    Información del Instituto Nacional del Cáncer sobre el tratamiento, la prevención y los exámenes de detección del cáncer de esófago, así como referencias a estudios clínicos, investigación, estadísticas y otros temas relacionados con este tipo de cáncer.

  13. Cáncer colorrectal

    Cancer.gov

    Información del Instituto Nacional del Cáncer sobre el tratamiento, la prevención, las causas y los exámenes de detección del cáncer de colon y recto, así como referencias a estudios clínicos, estadísticas y otros temas relacionados.

  14. Cáncer de pulmón

    Cancer.gov

    Información del Instituto Nacional del Cáncer sobre el tratamiento, la prevención, las causas y los exámenes de detección del cáncer de pulmón, así como referencias a estudios clínicos, investigación, estadísticas y otros temas relacionados.

  15. Cáncer de cabeza y cuello

    Cancer.gov

    Información del Instituto Nacional del Cáncer sobre el tratamiento, la prevención, las causas y los exámenes de detección de los cánceres de cabeza y cuello, así como referencias a estudios clínicos, investigaciones, estadísticas y temas relacionados.

  16. Cáncer de seno (mama)

    Cancer.gov

    Información del Instituto Nacional del Cáncer sobre el tratamiento, la prevención, la genética, las causas y los exámenes de detección del cáncer de seno (mama), así como referencias a estudios clínicos, investigación, estadísticas y temas relacionados.

  17. Cáncer de paratiroides

    Cancer.gov

    Información del Instituto Nacional del Cáncer sobre el tratamiento del cáncer de paratiroides, así como referencias a estudios clínicos, investigación y otros temas relacionados con este tipo de cáncer.

  18. Linfedema–para profesionales de salud (PDQ®)

    Cancer.gov

    Resumen de información revisada por expertos sobre la anatomía, la patofisiología, las manifestaciones clínicas, el diagnóstico y el tratamiento del linfedema relacionado con el cáncer, una afección en la que se acumula líquido linfático en los tejidos y causa inflamación..

  19. Delirio (PDQ®)

    Cancer.gov

    Resumen de información revisada por expertos acerca del delirio como una complicación del cáncer o su tratamiento. Se tratan enfoques de los cuidados médicos de apoyo y los abordajes farmacológicos para el manejo del delirio.

  20. Fatiga–para profesionales de salud (PDQ®)

    Cancer.gov

    Resumen de información revisada por expertos acerca de la fatiga, una afección caracterizada por extremo cansancio e incapacidad para funcionar por la falta de energía, que a menudo se observa como una complicación del cáncer y su tratamiento.

  1. Delirio –para profesionales de salud (PDQ®)

    Cancer.gov

    Resumen de información revisada por expertos acerca del delirio como una complicación a causa del cáncer o su tratamiento. Se discuten los enfoques de los cuidados médicos de apoyo, asi como farmacológicos para el manejo del delirio.

  2. Complicaciones gastrointestinales–para profesionales de salud (PDQ®)

    Cancer.gov

    Resumen de información revisada por expertos acerca del estreñimiento, la retención fecal, la obstrucción intestinal y la diarrea como complicaciones del cáncer o su tratamiento. Se discute el manejo de estos problemas.

  3. Náuseas y vómitos –para profesionales de salud (PDQ®)

    Cancer.gov

    Resumen de información revisada por expertos acerca de las náuseas y los vómitos como complicaciones a causa del cáncer o su tratamiento. Se discuten enfoques sobre el manejo de las náuseas y los vómitos.

  4. Memorias del Cuarto Simposio Internacional Sobre Polticas, Planificacin y Economa de los Incendios Forestales: Cambio Climtico e Incendios Forestales

    E-print Network

    Standiford, Richard B.

    Palabras clave: toma de decisiones, FARSITE, simulación de propagación del fuego, tratamientos de a menudo difícil, si no imposible. Así, muchas decisiones costosas de planificación de incendios se basan

  5. Tensión postraumática relacionada con el cáncer–para profesionales de salud (PDQ®)

    Cancer.gov

    Resumen de información revisada por expertos acerca de la tensión postraumática y síntomas relacionados en los pacientes con cáncer, sobrevivientes del cáncer y miembros de la familia. Se discuten la evaluación y tratamiento de estos síntomas.

  6. Cáncer de próstata–para profesionales de salud

    Cancer.gov

    Información del Instituto Nacional del Cáncer para profesionales de salud sobre el tratamiento, la prevención, las causas y los exámenes de detección del cáncer de próstata, así como referencias a estudios clínicos, investigación, estadísticas y otros temas relacionados.

  7. Neuroblastoma–para profesionales de salud

    Cancer.gov

    Información del Instituto Nacional del Cáncer para profesionales de salud sobre el tratamiento y los exámenes de detección del neuroblastoma, así como referencias a estudios clínicos, investigación y otros temas relacionados con este tipo de cáncer.

  8. Neuroblastoma

    Cancer.gov

    Información del Instituto Nacional del Cáncer sobre el tratamiento y los exámenes de detección del neuroblastoma, así como referencias a estudios clínicos, investigación y otros temas relacionados con este tipo de cáncer.

  9. On-Site Wastewater Treatment Systems: Sand Filters (Spanish) 

    E-print Network

    Lesikar, Bruce J.; Enciso, Juan

    2000-10-13

    publicaciones, Sistemas individuales para el tratamiento de aguas negras, es resultado de la colaboraci?n de varias agencias, organizaciones y fuentes de financiamiento. Queremos reconocer a los siguientes colaboradores: Texas State Soil and Water Conservation...

  10. On-Site Wastewater Treatment Systems: Evapotranspiration Bed (Spanish) 

    E-print Network

    Lesikar, Bruce J.; Enciso, Juan

    2002-04-18

    individuales para el tratamiento de aguas negras, es resultado de la colaboraci?n de varias agencias, organizaciones y fuentes de financiamiento. Queremos reconocer a los siguientes colaboradores: Texas State Soil and Water Conservation Board USEPA 319(h...

  11. Mejor atención de niños con cáncer se asocia a esperanzas de vida más largas

    Cancer.gov

    Nuevos datos del Estudio sobre supervivientes de cánceres infantiles indican que las mejoras en el tratamiento de cánceres infantiles durante las últimas décadas han ayudado a extender la esperanza de vida de muchos supervivientes de cánceres infantiles.

  12. Carcinoma de tumor primario desconocido–para profesionales de salud

    Cancer.gov

    Información del Instituto Nacional del Cáncer para profesionales de salud sobre el tratamiento del carcinoma de tumor primario desconocido, así como referencias a estudios clínicos y otros temas relacionados.

  13. Conversion de las tablas del Lexico-Gramatica del frances en el lexico LGLex

    E-print Network

    Boyer, Edmond

    Introducci´on Los vol´umenes de informaci´on textual disponibles hoy en d´ia hacen imposible el tratamiento manual de la informaci´on, con lo cual el tratamiento autom´atico inteligente se convierte en una franc´es. El impacto est´a en aplicaciones muy diversas, desde extracci´on de informaci´on a apoyo al

  14. Conferencia de Consenso sobre la braquiterapia en cáncer de mama en estadios iniciales

    Microsoft Academic Search

    F. Guedea; L. Arribas; F. Casquero; C. Cinos; V. Crispin; A. Gracia; J. L. Guinot; I. Monteiro-Grillo; V. Munoz; J. Pera; A. Polo; L. Linares; H. Marsiglia; J. J. Mazeron

    2003-01-01

    Resumen  Existe una controversia desde hace décadas sobre el papel de la sobredosis después de la radioterapia externa en el tratamiento\\u000a conservador de cáncer de mama inicial. En el caso de comparar la supervivencia y el control local de un tratamiento conservador\\u000a frente a la mastectomía, existen en la literatura 5 estudios randomizados1–5 y un metaanálisis6 que demuestran que la radioterapia

  15. [Efficacy of racecadotril vs. smectite probiotics or zinc as an integral part of treatment of acute diarrhea in children under five years: A meta-analysis of multiple treatments].

    PubMed

    Gutiérrez-Castrellón, Pedro; Ortíz-Hernández, Anna Alejandra; Llamosas-Gallardo, Beatriz; Acosta-Bastidas, Mario A; Jiménez-Gutiérrez, Carlos; Diaz-García, Luisa; Anzo-Osorio, Anahí; Estevez-Jiménez, Juliana; Jiménez-Escobar, Irma; Vidal-Vázquez, Rosa Patricia

    2015-01-01

    Racional del estudio: A pesar de los grandes avances en su tratamiento, la diarrea aguda continúa representando un problema de salud pública en menores de cinco años. Existe poca sistematización en el tratamiento, y la mayor parte de publicaciones establecen comparaciones del coadyuvante con placebo. Objetivo: Analizar, mediante una revisión sistemática, la evidencia sobre la eficacia comparativa de los coadyuvantes para el tratamiento de la diarrea aguda y presentar las comparaciones a través de un meta-análisis de tratamientos múltiples. Métodos: Búsqueda sistematizada en múltiples bases de datos de todos los ensayos clínicos relacionados con la utilización de racecadotrilo, smectita, Lactobacillus GG, Lactobacillus reuteri, Sacharomyces boulardii y zinc como coadyuvantes en diarrea aguda, evaluando como desenlace primario la duración de la diarrea. Estadísticamente la información se analizó a través de la estrategia de meta-análisis de tratamientos múltiples, evaluando la superioridad de cada medicamento mediante un análisis SUCRA. Resultados: Se demuestra la eficacia del racecadotrilo al compararlo con placebo y con el resto de los coadyuvantes analizados. La evaluación de la superioridad terapéutica situó al racecadotrilo en primer lugar, seguido por smectita y, después, L. reuteri. Conclusión: Desde el punto de vista de toma estratégica de decisiones en salud, el meta-análisis de tratamientos múltiples nos permite establecer la superioridad terapéutica del racecadotrilo como coadyuvante en el manejo integral de la diarrea aguda en menores de cinco años. PMID:26089269

  16. Neuroimagen en la enfermedad de Alzheimer: nuevas perspectivas

    PubMed Central

    Becker, James T.

    2012-01-01

    Introducción y desarrollo En los próximos 50 años vamos a presenciar un incremento significativo de la población mayor de 65 años y por lo tanto va a aumentar, considerablemente, el número de individuos con riesgo de desarrollar demencias neurodegenerativas, especialmente la enfermedad de Alzheimer (EA). Las estrategias actuales de tratamiento farmacológico y no farmacológico se han centrado en las fases sintomáticas de esta enfermedad y, gradualmente, vamos teniendo una mayor comprensión de los posibles factores de riesgo del síndrome clínico. Conclusiones Los estudios de neuroimagen han sido muy útiles para mostrar los cambios estructurales del envejecimiento normal y patológico, así como también los factores de riesgo para la EA. Los tratamientos apropiados de los factores de riesgo y su posible combinación con tratamientos específicos para la EA podrían prolongar el período presintomático de la EA y, por tanto, mejorar la calidad de vida y disminuir la carga para el paciente, la familia y la sociedad. PMID:20517866

  17. Paleoceanography and Ice Sheet-Ocean Interactions on the Central West Greenland Margin, LGM through Deglaciation

    NASA Astrophysics Data System (ADS)

    Jennings, A. E.; Andrews, J. T.; Ó Cofaigh, C.; St-Onge, G.; Belt, S. T.; Cabedo-Sanz, P.; Dowdeswell, J. A.

    2014-12-01

    Hemipelagic sediments in several central West Greenland trough mouth fan cores are critical for testing whether an ice shelf covered Baffin Bay during the late LGM and H1 (core HU2008029-12PC) and to investigate the role of ocean warming in initiating and/or sustaining retreat of the Greenland Ice Sheet from the shelf edge (cores JR175-VC29 & -VC46). We use benthic and planktic foram assemblages, IP25 sea ice biomarker, ice-rafted detritus (IRD), lithofacies and quantitative mineralogy to reconstruct paleoceanographic conditions. HU2008029-12PC comprises bioturbated, thin turbidites and hemipelagic sediments with Greenlandic provenance from >19.2 to 16.7 cal ka BP. Abundance spikes of planktic forams provide the radiocarbon dates in this interval and coincide with abundance spikes of benthic foram species indicative of chilled Atlantic Water and episodic marine productivity. IRD and IP25 are rare in this interval. These characteristics are consistent with the ice margin at the shelf edge meeting a heavily sea-ice covered ocean with chilled Atlantic Water at depth, rather than an ice shelf-covered ocean. Initial deglaciation from the West Greenland margin began c. 16.7 ka BP, as recorded by a lithofacies shift from turbidites to bioturbated mud with dispersed IRD and continued presence of Atlantic Water benthic species. After 16.7 ka BP, IP25, large diatoms and benthic forams indicative of sea-ice edge productivity show warming conditions. By 15.2 ka BP Greenlandic IRD and meltwater species, Elphidium excavatum, reflect accelerated ice sheet ablation. By 14.4 ka BP a strong rise in IP25 content, introduction of key Atlantic Water species Cassidulina neoteretis, and IRD spikes rich in detrital carbonate with a northern Baffin Bay provenance provide evidence for increased advection of West Greenland Current, collapse of the LIS ice streams, and formation of an IRD belt along the W. Greenland margin during the Bølling-Allerod and early Holocene warm intervals.

  18. Identification of Tick-Borne Pathogens in Ticks Feeding on Humans in Turkey

    PubMed Central

    Orkun, Ömer; Karaer, Zafer; Çakmak, Ay?e; Nalbanto?lu, Serpil

    2014-01-01

    Background The importance of tick-borne diseases is increasing all over the world, including Turkey. The tick-borne disease outbreaks reported in recent years and the abundance of tick species and the existence of suitable habitats increase the importance of studies related to the epidemiology of ticks and tick-borne pathogens in Turkey. The aim of this study was to investigate the presence of and to determine the infection rates of some tick-borne pathogens, including Babesia spp., Borrelia burgdorferi sensu lato and spotted fever group rickettsiae in the ticks removed from humans in different parts of Ankara. Methodology/Principal Findings A total of 169 ticks belonging to the genus Haemaphysalis, Hyalomma, Ixodes and Rhipicephalus were collected by removing from humans in different parts of Ankara. Ticks were molecularly screened for Babesia spp., Borrelia burgdorferi sensu lato and spotted fever group rickettsiae by PCR and sequencing analysis. We detected 4 Babesia spp.; B. crassa, B. major, B. occultans and B. rossi, one Borrelia spp.; B. burgdorferi sensu stricto and 3 spotted fever group rickettsiae; R. aeschlimannii, R. slovaca and R. hoogstraalii in the tick specimens analyzed. This is the report showing the presence of B. rossi in a region that is out of Africa and in the host species Ha. parva. In addition, B. crassa, for which limited information is available on its distribution and vector species, and B. occultans, for which no conclusive information is available on its presence in Turkey, were identified in Ha. parva and H. marginatum, respectively. Two human pathogenic rickettsia species (R. aeschlimannii and R. slovaca) were detected with a high prevalence in ticks. Additionally, B. burgdorferi sensu stricto was detected in unusual tick species (H. marginatum, H. excavatum, Hyalomma spp. (nymph) and Ha. parva). Conclusions/Significance This study investigates both the distribution of several tick-borne pathogens affecting humans and animals, and the presence of new tick-borne pathogens in Turkey. More epidemiological studies are warranted for B. rossi, which is very pathogenic for dogs, because the presented results suggest that B. rossi might have a wide distribution in Turkey. Furthermore, we recommend that tick-borne pathogens, especially R. aeschlimannii, R. slovaca, and B. burgdorferi sensu stricto, should be taken into consideration in patients who had a tick bite in Turkey. PMID:25101999

  19. Cáncer de piel–para profesionales de salud

    Cancer.gov

    Información del Instituto Nacional del Cáncer para profesionales de salud sobre el tratamiento, la prevención, las causas y los exámenes de detección del cáncer de piel, así como referencias a estudios clínicos, investigación y otros temas relacionados con este tipo de cáncer.

  20. CONTEXTO PRAGMÁTICO, GÉNEROS Y COMPRENSIÓN LECTORA DE RESÚMENES CIENTÍFICOS EN INGLÉS

    Microsoft Academic Search

    Piedad Fernández Toledo

    2000-01-01

    Resumen: El objetivo de este artículo es validar empíricamente la existencia de un componente en el conocimiento previo del lector, como son los esquemas de género o retóricos, a tener en cuenta tanto en la enseñanza de lenguas extranjeras, como en el análisis y tratamiento documental. Se defiende la inclusión de un componente pragmático que incluya el objetivo de comunicación

  1. Números: simplicidad conceptual, complejidad curricular

    Microsoft Academic Search

    Luis Rico Romero

    ¿De quién es el conocimiento sobre el número?, ¿quién determina su tratamiento curric- ular? Cuestiones similares han sido propuestas recientemente por Michael Apple ( ¿De quién es el conocimiento que más valor tiene?, ¿de quién es este curriculo? ), y se plantean en toda su crudeza cuando, como en la actualidad, se trabaja sobre modificaciones importantes del currícu- lo. En

  2. Los Derechos de los Pacientes del Centro Clnico

    E-print Network

    Los Derechos de los Pacientes del Centro Clínico Los Derechos de los Pacientes del Centro Clínico medir las respuestas de los pacientes al tratamiento. Existen procesos que protegen los derechos de paciente que se observen los derechos fundamentales de la dignidad humana. Esta Declaración de Derechos

  3. CRIA DE LARVAS DE RHAMDIA SAPO (VAL.) EIG. EN ESTANQUES PRIMEROS ENSAYOS

    Microsoft Academic Search

    Laura Luchini; Toribio Avendaño Salas

    1983-01-01

    RESUMEN El objetivo fue contribuir al desarrollo de metodologías de cultivo para larvas de bagre sapo, determinando el tipo adecuado de tratamiento previo en los estanques de cría, el alimento (natural o artificial) que mejor favorece su crecimiento, así como el tiempo de cultivo para esta etapa. Los primeros ensayos indicaron como más conveniente el procedimiento de fertilización previa con

  4. El equilibrio correcto: cómo ayudar a los supervivientes de cáncer a tener un peso saludable

    Cancer.gov

    La obesidad ha sido relacionada con un aumento en el riesgo de recidiva y muerte por varios tipos de cáncer. Existen intervenciones para ayudar a los supervivientes a mantener un peso saludable, reducir el riesgo de recidiva y muerte por cáncer y disminuir la probabilidad de padecer efectos tardíos y crónicos del tratamiento.

  5. Experto Universitario Java Enterprise 2012-2013 Depto. Ciencia de la Computacin e IA

    E-print Network

    Escolano, Francisco

    Experto Universitario Java Enterprise © 2012-2013 Depto. Ciencia de la Computación e IA Lenguaje Java Avanzado Sesión 3: Tratamiento de errores #12;Lenguaje Java Avanzado © 2012-2013 Depto. Ciencia de · Tipos genéricos #12;Lenguaje Java Avanzado © 2012-2013 Depto. Ciencia de la Computación e IA Errores - 3

  6. Haseltonia 14: 161169. 2008 161 1. Introduction

    E-print Network

    Zürich, Universität

    species occur in cen- Abstract: The most recent treatments of the family Cactaceae for Uruguay floccosa are new records for the flora of Uruguay. The occurrence of Epiphyllum phyllanthus in Uruguay could not be confirmed. Resumen: Los tratamientos mas recientes de la familia Cactaceae para Uruguay son

  7. COMPARACIÓN ENTRE LA TERAPIA CONVENCIONAL ODONTOLÓGICA Y SU USO COMBINADO CON LA FISIOTERAPIA Y LA OSTEOPATÍA, EN PACIENTES CON DISFUNCIÓN TEMPOROMANDÍBULAR. \\

    Microsoft Academic Search

    Graciela Carvallo; Maria Fasanella; Sofia Caricote

    RESUMEN Dado que la disfunción temporomandibular es una patología que cursa frecuentemente con, dolor y limitación en la apertura bucal los pacientes afectados reducen su calidad de vida desde el punto de vista social, laboral y familiar. La presente investigación tiene como propósito evaluar comparativamente los alcances terapéuticos entre el tratamiento odontológico convencional y el uso combinado de éste, con

  8. TOTAL MUJERES MSTER EN ESPACIOS NATURALES PROTEGIDOS. 32 17

    E-print Network

    Autonoma de Madrid, Universidad

    CUIDADOS PALIATIVOS Y TRATAMIENTO DE SOPORTE DEL ENFERMO NEOPLÁSICO 37 32 MÁSTER EN FISIOTERAPIA RESPIRATORIA Y CARDIACA (E.U. DE FISIOTERAPIA DE LA ONCE) 27 16 MÁSTER EN I + D DEL MEDICAMENTO 21 13 MÁSTER EN FISIOTERAPIA OSTEOARTICULAR (E.U. DE FISIOTERAPIA DE LA ONCE) 96 72 EXPERTO EN MEDICINA TROPICAL 50 41 TOTAL

  9. Ni genio ni farsante : Edgar Allan Poe y Eureka

    Microsoft Academic Search

    G. St. John Stott

    2009-01-01

    Eureka (1848) ha sido considerado superficialmente como una versión expandida de una conferencia sobre cosmología que Poe había dado ese mismo año. Sin embargo, la seriedad de este trabajo como un trabajo científico debería ser cuestionada. El tratamiento de algunos temas, que se encuentran en otros escritos de Poe, muestra que el autor no busca ser consistente. Entonces, el texto

  10. ESCUELA COMPLUTENSE LATINOAMERICANA Modelos de Simulacin Estocstica

    E-print Network

    Figueira, Santiago

    ;Modelos de Simulación- 3 I. Modelado de sistemas mediante simulación TRATAMIENTO DEL TIEMPO RELOJ DE cuenta instantes exactos (no error) 0 s1 s2 s3 #12;Modelos de Simulación- 5 I. Modelado de sistemas PROGRAMACIÓN Ejecutar y comparar con modelo 5. VALIDAR EL MODELO Ejecutar y comparar con sistema o solución

  11. Etapa final de la vida (PDQ®)

    Cancer.gov

    Sumario informativo revisado por expertos sobre el tratamiento y la atención del paciente de cáncer desde los últimos días hasta las últimas horas de vida; esto incluye los síntomas comunes, los dilemas éticos que pueden surgir y la función que desempeña el oncólogo en proveer cuidados al paciente y su familia durante este período.

  12. Cánceres infantiles

    Cancer.gov

    Los cánceres infantiles no siempre se tratan como los cánceres en adultos. La oncología pediátrica es una especialización médica que se concentra en la atención de niños con cáncer. Es importante saber que existen estos conocimientos especializados y que hay tratamientos eficaces para muchos cánceres infantiles.

  13. ¿Por Qué un Banco Público de Células Madre de Sangre de Cordon Umbilical en Colombia?

    Microsoft Academic Search

    JULIETA HENAO PÉREZ; EUGENIA CRISTINA; PACHECO PINEDO; GERMÁN DAVID; ARBOLEDA TORO; GÓMEZ ARISTIZABAL; LUZ MARINA; RESTREPO MÚNERA

    2005-01-01

    El trasplante de células madres hematopoyéticas (CMH) obtenidas de médula ósea (MO) se ha convertido en el tratamiento de elección para diferentes desórdenes hematológicos. Pero éste presenta dificultades, que pueden mejorarse con el uso de de sangre de cordón umbilical (SCU), fuente importante de CMH de rápida disponibilidad, fácil obtención, inofensivo para el donante, menor restricción de histocompatibilidad (HLA), menor

  14. SISTEMA DE INFORMACIÓN TURÍSTICO DESDE PRESUPUESTOS ECOLÓGICOS Y FOLKSONÓMICOS

    Microsoft Academic Search

    Iraimi Bermúdez García; Ramón Antonio Rodríguez Piña; Renier Castillo García; Ines Maria Marrero Ramírez

    2009-01-01

    El reto de diseñar e implementar un Sistema de Información, -y de ahora en lo adelante SI-, no resulta un ejercicio simple. El tratamiento a la información desde las perspectivas de Producto y Proceso de Gestión, conlleva a confusión e incertidumbre. Al certero decir de Alfons Cornella ... “Las organizaciones deben entender mejor en qué consiste la información, y deben

  15. Extraccion de lineas melodicas a partir de imagenes de partituras musicales

    E-print Network

    Pantrigo Fernández, Juan José

    encontrados en el estado del arte de los sistemas OMR (Optical Music Recognition) combinadas con aportaciones) [7]. La mayor parte de los sistemas que utilizan una representaci´on simb´olica de la imagen. Estas son las etapas t´ipicas de un sistema de tratamiento digital de im´agenes. La mayor´ia de los

  16. El análisis de las interacciones grupales: las aplicaciones SOCIOS

    Microsoft Academic Search

    José Manuel Cornejo Álvarez

    2006-01-01

    El concepto de ‘interacción’ representa uno de los núcleos fundamentales de la Psicología Social. En los grupos y las organizaciones, esto significa focalizar las explicaciones de los fenómenos en el sistema de relaciones de “influenciarecíproca” que se establece entre sus componentes. El análisis de las matrices de interacción requiere la utilización de algoritmos específicos de tratamiento de la información, no

  17. Nutrient Availability in Rangeland Soils: Influence of Prescribed Burning, Herbaceous Vegetation Removal, Overseeding with Bromus tectorum, Season, and Elevation

    E-print Network

    Removal, Overseeding with Bromus tectorum, Season, and Elevation R. R. Blank,1 J. Chambers,2 B. Roundy,3 prescribed burning, herbaceous vegetation removal, and controls. Cheatgrass (Bromus tectorum L´ Bromus tectorum L. en pequen~as subparcelas dentro de cada tratamiento. Posterior a la aplicacio´n de

  18. EL ABOGADO DEL NIÑO COMO GARANTE DEL PLENO EJERCICIO DE LOS DERECHOS DE LOS MENORES DE EDAD

    Microsoft Academic Search

    Lisbeth Rodríguez Martín; Yanelys Palmero Martín

    2012-01-01

    El tratamiento de la niñez y sus derechos resulta tema de interés universal para las ciencias jurídicas modernas, debido a las nuevas tendencias de protección surgidas a partir de la celebración de los Congresos Panamericanos del Niño y la Convención sobre los Derechos del Niño. De modo, que para las ciencias jurídicas cubanas se hace de suma importancia el estudio

  19. Bronchopulmonary dysplasia (pulmonologist's point of view)

    Microsoft Academic Search

    Carlos E. Sabogal Rosas; Isaac Talmaciu

    2008-01-01

    RESUMEN La displasia broncopulmonar describe los trastornos respiratorios crónicos asociados primariamente con el nacimiento prematuro y sus tratamientos. Su definición, factores de riesgo, características radiológicas y patológicas han evolucionado con el tiempo, debido a los cambios en los cuidados de los recién nacidos prematuros. Sus características clínicas involucran no sólo al sistema respiratorio sino también al cardiovascular, gastrointestinal y al

  20. IMPLICACIONES DEL MODELO DE ENSEÑANZA NATURAL DEL LENGUAJE EN LA INTERVENCION DE PERSONAS CON AUTISMO

    Microsoft Academic Search

    Pedro Gortázar

    Equipo CEPRI RESUMEN: El Modelo de Tratamiento Natural del Lenguaje constituye el para- digma de intervención actualmente más válido para hacer frente a los déficits sociales y comunicativos de las personas con autismo. En esta ponencia se discuten las implicaciones de este Modelo de cara a la formu- lación de objetivos curriculares, definición de criterios de respuesta, técnicas de entre-

  1. Trastorno por déficit de atención con hiperactividad: orientaciones psicoeducativas para los padres

    Microsoft Academic Search

    López Villalobos; S. Alberola López; José Antonio López Villalobos

    2008-01-01

    Resumen Se exponen orientaciones psicoeducativas para padres de niños con trastorno por déficit de atención con hiperactividad (TDAH), basadas en criterios empíricos, teóricos y clínicos, abor- dando las siguientes dimensiones: ambiente familiar, modelado, refuerzo de conducta, normas, autonomía y autoestima, aprender a pensar y saber esperar, atención, relación con compañeros, grupo familiar, adolescencia y una reflexión sobre el tratamiento. Palabras

  2. Histamine release and mast cell degranulation induced by 2-4 dinitrophenol in rat tissues

    Microsoft Academic Search

    Mercedes P. de Oliveira Antonio; A. M. Rothschild

    1969-01-01

    Resumen El 2–4-dinitrofenol es capaz de producir degranulación rápida aunque parcial de mastocitos y liberación de histamina de los tejidos de la rata in vitro. Estos efectos solamente pueden ser demostrados en tejidos mantenidos a baja temperatura antes del tratamiento; son inhibidos por glucosa. La estimulación del consumo de oxígeno no parece ser la causa de los efectos del dinitrofenol.

  3. Formacin Integral en Odontologa

    E-print Network

    Rey Juan Carlos, Universidad

    Formación Integral en Odontología para el Auxiliar y el Higienista Dental III Edición INFORMACIÓN PLAZAY MATRÍCULA Título: : Formación Integral en Odontología para el Auxiliar y el Higienista Dental. III caries y radiología · Diagnóstico precoz de la caries. · Tratamiento no operatorio de la caries

  4. 12. Laboratorios de investigacin 12.1. Laboratorio de Conducta y Sistemas Dinmicos (LabCSD)

    E-print Network

    Oro, Daniel

    educadores sobre problemas infantiles, evaluación del Trastorno por Déficit de Atención e Hiperactividad o de, evaluación de trastornos emocionales o tratamiento del miedo a volar en avión y de otras fobias específicas, entre otros trastornos ansiosodepresivos. Proyectos de investigación en curso: -- Estudio aleatorio

  5. La teoría económica y financiera del precio: dos enfoques complementarios

    Microsoft Academic Search

    Javier Bernardo Cadena Lozano

    2011-01-01

    resumen El análisis de los precios ha sido abordado desde varios enfoques y por ello su tratamiento difiere. No puede decirse que éstos son excluyentes; por el contrario, existe una fuerte relación entre ellos, la que, sin embargo, poco se reconoce en el ámbito académico y empresarial de los teóricos de las finanzas y el marketing, por desconocer la fundamentación

  6. 11.1.9. Servicio de Prevencin La doctora Francesca Garcias, profesora titular del Departamento de Fsica, se ha

    E-print Network

    Oro, Daniel

    personal investigador en formación. También se han realizado diversos estudios sobre riesgos específicos y 17 incidentes sin baja, y se ha realizado la investigación pertinente en cada caso. Planes de); 16 de evaluación, tratamiento y seguimiento de casos psicosociales individuales, y 10 consultas y

  7. SMALL MAMMALS AND GROUND-DWELLING INVERTEBRATES ASSOCIATED WITH ACTIVE AND CONTROLLED COLONIES OF

    E-print Network

    Wallace, Mark C.

    OF BLACK-TAILED PRAIRIE DOGS (CYNOMYS LUDOVICIANUS) RACHEL E. MCCAFFREY,* MARK C. WALLACE, AND JAMES D. RAY (Cynomys ludovicianus), PhostoxinH-treated colonies, and non- colonized short-grass prairie to assess de las praderas de cola negra (Cynomys ludovicianus), en colonias con tratamiento de PhostoxinH, y en

  8. B8. RESPUESTA DE GYPSOPHILA (Gypsophila paniculata var. Bambino) A LA INYECCIÓN DE CO 2 EN SUS DIFERENTES FASES FENOLÓGICAS. GUAYLLABAMBA, PICHINCHA*. RESPONSE OF GYPSOPHILA (Gypsophila paniculata var. Bambino) TO THE INJECTION OF CO 2 IN DIFFERENT PHENOLOGIC PHASES. GUAYLLABAMBA, PICHINCHA

    Microsoft Academic Search

    con cuatro repeticiones. La unidad experimental net a fue 20m 2 (20mx1m). Las variables evaluadas fueron: Incremento de altura y diámetro, número de brotes, producción de tallos, peso de tallos en verde, determinación de m ateria seca, peso de tallos en blanca, número de días de apertura de flor, número de días en florero y análisis económico. El tratamiento que

  9. Añadir quimioterapia después de la radioterapia mejora la supervivencia de adultos con un tipo de tumor cerebral de crecimiento lento

    Cancer.gov

    Adultos con gliomas de grado bajo, una forma de tumor cerebral, que recibieron tratamiento con quimioterapia después de la radioterapia vivieron más tiempo que pacientes que recibieron solo radioterapia, según los resultados de seguimiento a largo plazo de un estudio clínico aleatorizado y controlado, subvencionado por los NIH.

  10. "La escenificacin del espacio del santo en dos obras de Lope de Vega : Barln y Josaf y El santo negro Rosambuco"

    E-print Network

    Boyer, Edmond

    1 17/02/2010 "La escenificación del espacio del santo en dos obras de Lope de Vega : Barlán y piezas, la inventiva de Lope de Vega resuelve la puesta en teatro del espacio propuesto por la fuente según los episodios, se traduce por técnicas diversas de tratamiento del espacio dramático, y por otra

  11. On-Site Wastewater Treatment Systems: Leaching Chambers (Spanish) 

    E-print Network

    Lesikar, Bruce J.; Enciso, Juan

    2000-10-13

    cada 3 a?os. Si se lleva a cabo un mantenimiento m?s frecuente el costo aumentar?. La serie de publicaciones, Sistemas individuales para el tratamiento de aguas negras, es resultado de la colaboraci?n de varias agencias, organizaciones y fuentes de...

  12. Sepsis por Salmonella enteritidis en una paciente con lupus eritematoso sistémico

    Microsoft Academic Search

    Carlos Alberto Cañas; Gustavo Adolfo Ospina; María Elena Ochoa; Juan Diego Vélez

    Resumen Presentamos el caso clínico de una paciente de 28 años de edad con Lupus Eritematoso Sistémico (LES), con compromiso a nivel neurológico central, riñón y sistema hematológico, con tratamiento cró- nico de esteroides y desnutrición avanzada, quien desarrolla sepsis por Salmonella enteritidis, germen aislado en muestras tomadas en lavado bronco alveolar, sangre y materia fecal. Presentó un absce- so

  13. The Late Holocene Stratigraphy of an Inlet-Dominated Barrier Island, Pea Island, North Carolina.

    NASA Astrophysics Data System (ADS)

    Smith, C. G.; Ames, D.; Corbett, D. R.; Culver, S.; Mallinson, D.; Riggs, S. R.; Vance, D.

    2002-12-01

    Sedimentological, foraminiferal, geochemical, and geophysical data sets as well as aerial photographs have been used to investigate the natural processes (inlet dynamics, ocean/estuarine washover, and sea-level change) responsible for the late Holocene units preserved in the barrier island subsurface at Pea Island National Wildlife Refuge. Historic nautical charts indicate that three inlets characterized Pea Island between early European exploration (1590) and the late 19th century; aerial photographs show New Inlet open in 1932 and 1940. Vibracores (up to 5.5 m) collected along three transects across Pea Island extend our knowledge of the geological evolution of this region to pre-historic times. The section in the longest core (PI01S6) consists of four fining-upwards depositional sequences. The basal unit of each sequence is a bedded, medium to fine, clean quartz sand with increasing concentrations of organic matter (3-4 % detrital and 5-7 % in situ Spartina alterniflora roots) or irregular mud clasts (2-5 cm) to spherical mud balls (1-2 cm) up core. The clean sand units have so far proven to be barren of foraminifera except for a shelly unit at ca. 220 cm below MSL. The foraminiferal assemblage in this unit is of open shelf character (Elphidium excavatum, Hanzawaia strattoni, and Buccella inusitata). A 14C age on a disarticulated Chione cancellata valve from this unit is cal. 930+/-60 BP. The sand grades into a gray, tight mud in the first two sequences and into an inter-laminated mud and in situ peat in the third sequence. The peat contains leaf fragments and rhizomes of the marsh plants Juncus roemarianus, Spartina cynosuroides, and/or Phragmites spp. The peat and muddy sand units contain marsh foraminifera (Trochammina spp., Miliammina fusca, Arenoparrella mexicana), which are also found in modern marsh deposits. A peat sample from the third fining upward sequence (the only one to grade into a true peat) has a 14C age of cal. 395+/-35 BP, cal. 295+/-35 BP, or cal 180+/-40 BP. The four fining-upwards sequences have sharp erosional basal contacts. These deposits appear to reflect back-barrier processes including sequential deposition of flood-tide delta sands and/or sound sands adjacent to marshes. The shelly sands, containing open shelf foraminiferal assemblages, represent oceanic overwash, inlet deposits, or open embayment sands deposited behind a laterally extensive breach in the barrier island. The sequences are capped by the deposits of modern environments that include algal flats, tidal creeks, high and low marshes, back-barrier berms, overwash fans, and aeolian dunes. Several of the modern environments became covered with marsh vegetation after the construction of barrier dune ridges in the late 1930?s.

  14. Modelos de Simulacin Estocstica: Simulando la Aleatoriedad

    E-print Network

    Figueira, Santiago

    ;Modelos de Simulación- 3 I. Modelado de sistemas mediante simulación TRATAMIENTO DEL TIEMPO RELOJ DE cuenta instantes exactos (no error) 0 s1 s2 s3 #12;Modelos de Simulación- 5 I. Modelado de sistemas PROGRAMACI�N Ejecutar y comparar con modelo 5. VALIDAR EL MODELO Ejecutar y comparar con sistema o solución

  15. Capacitación del personal y de los pacientes en torno a los cuidados terminales

    Cancer.gov

    Al no abordar el tema de la transición de un tratamiento activo para el cáncer a los cuidados en la etapa final de la vida, los médicos pueden desconocer lo que un paciente realmente desea y esto puede ser motivo de angustia para pacientes y familiares. Los investigadores han diseñado programas innovadores para ayudar a médicos y pacientes a mejorar sus habilidades de comunicación y a sentirse más cómodos al hablar de este tema.

  16. Revista "Computacion y Sistemas", Vol. 8, No. 4, June 2005 Segmentacion de imagenes en color utilizando

    E-print Network

    Angulo,Jesús

    Revista "Computaci´on y Sistemas", Vol. 8, No. 4, June 2005 Segmentaci´on de im´agenes en color) recientemente propuesta (mejorando al sistema HLS), y que tienen caracter´isticas apropiadas para el tratamiento informaci´on de intensidad o/y la informaci´on espacial. Para las im´agenes a nivel de gris, una de las t

  17. Part 13, Authors: R To Rzoska 

    E-print Network

    Humphrey, Judith M.; Ray, Doris H.; Hassall, Albert; Doss, Mildred A.

    1951-01-01

    ' ''''- ismit?i- :?. ?;.! ?.'' . . - ?? i?H>iii4 ???*??*?|8.?m] '..-i - ria ' ? ? ??! ?> !?> ???1 ?? IfcfcsS ^"t..., London (3290), v. 130, Nov. 19, pp. 784- 785. [W*.] R., L.1 1935 a.?Tratamiento de la amibiasis intestinal

  18. Programa de formación en Psico-Oncología para residentes de Psiquiatría y Psicología Clínica: modelo de interconsulta

    Microsoft Academic Search

    María Francisca Hollenstein Prat; Jorge Maté Méndez; Francisco Luis Gil Moncayo

    2003-01-01

    Resumen  La formación en Psico-Oncología tiene como objetivo principal dotar al residente de Psicología Clínica y Psiquiatría de los\\u000a conocimientos teórico-prácticos y de las habilidades clínicas necesarias para la evaluación, el diagnóstico y el tratamiento\\u000a psicológico de las reacciones emocionales y de los trastornos psicopatológicos presentes en el paciente con cáncer y sus familiares,\\u000a así como la adquisición de habilidades y

  19. El Centro para la Salud Mundial del NCI anuncia las primeras becas de investigación para apoyar las tecnologías portátiles

    Cancer.gov

    El Centro para la Salud Mundial del NCI (CGH) anunció el otorgamiento de subvenciones que apoyarán el desarrollo y la validación de tecnologías portátiles y de bajo costo. Estas tecnologías tienen el potencial de mejorar la detección temprana, el diagnóstico y los tratamientos no invasivos o mínimamente invasivos de varios tipos de cáncer con una prevalencia particularmente alta en ciertos países con economías de ingreso bajo y mediano.

  20. Controlling the Pecan Nut Casebearer (Spanish)

    E-print Network

    Knutson, Allen E.; Ree, Bill

    2001-04-11

    ?n tendr?a por lo menos una semana de adelanto con respecto a un tratamiento m?s oportuno, o podr?a resultar totalmente innece- saria. Los estudios realizados indican que el n?mero de palomillas capturadas refleja con precisi?n la activi- dad de las...?as y lluviosas, ya que esto puede retrasar la oviposici?n. Si durante este muestreo encuentra menos de tres racimos infestados no se justi- fica la aspersi?n. Cuando en este momento se tienen infestaciones de tres o m?s racimos esto indica que podr...

  1. Drinking Water Problems: Perchlorate (Spanish) 

    E-print Network

    Dozier, Monty; Melton, Rebecca; Hare, Michael; Porter, Dana; Lesikar, Bruce J.

    2006-02-21

    calificado para determinar la calidad del agua. Una lista de laboratorios certificados por la Comisi?n Tejana para la Calidad Ambiental (TCEQ por sus siglas en ingl?s) para realizar pruebas al agua potable puede encontrarse en: http://www.tnrcc.state. tx.us... y perju- dicar la calidad del agua tratada. El agua que sale de las unidades de tratamiento debe de ser examinada regularmente para verificar el funcionamiento apropiado del sistema. 4 Fuentes Burge, S., and Halde, R. 1999. Nitrate and Perchlorate...

  2. On-Site Wastewater Treatment Systems: Constructed Wetlands (Spanish)

    E-print Network

    Lesikar, Bruce J.; Enciso, Juan

    2002-04-18

    ?n, cloruro de polivinilo, ?Hypalon? o hule ?PondGard? de terpol?mero de etileno-propileno y dieno (EPDM). El lecho en s? es normalmente de grava pero puede ser de cualquier material poroso que no se corroe o disuelva con las aguas negras. El lecho de medio... acu?ticas. Quita nutrientes, materia org?nica, s?lidos en suspensi?n y pat?genos. a19 Un sistema de aplicaci?n en suelo. Dispersa las aguas negras en la tierra para el tratamiento y disposici?n final o reutilizaci?n. Los sistemas de humedal artifi...

  3. La mujer y el amor en El mismo mar de todos los veranos, de Esther Tusquets 

    E-print Network

    Reed, Linnette Fourquet

    1985-01-01

    . Al fin y al cabo es esta la base del fsnunismo en cualquier sociedad. Es claro que en los textos de estas escritoras no se nos presentan criticas abiertas a la sociedad sexista es- panola, imposible hacerlo en una sociedad de tipo represivo, pero... no publicaba en Espana desde los ahos sesenta y por lo tanto no teru. a que pasar por los avatares de la censura. De todas maneras, lo que es claro en ambos, con el tratamiento de estos temas tabues, es el deseo de rrastrar un rechazo de las que eran...

  4. Mosquito Control Around the Home (Spanish) 

    E-print Network

    Jackman, John A.; Olson, Jimmy K.

    2003-03-17

    a73 Usar repelentes cuando se visite cualquierlocalidad infestada por mosquitos . Productos que contienen DEET han mostra-do ser los repelentes m?s confiables . a73 P ara alivio temporal en patios o ?reas de descanso o picnic , usar candelas o...?ticospueden ser afectados por tratamientos conaceites .Contr ol a largo plazo P ara un control efectiv o y a largo plazo se requiere el uso de v arias t?cnicas de manejo. El control de mosquitos es usualmente com-plejo y costoso, y requiere de la cooperaci...

  5. Drinking Water Problems: Radionuclides (Spanish) 

    E-print Network

    Lesikar, Bruce J.; Melton, Rebecca; Hare, Michael; Hopkins, Janie; Dozier, Monty

    2006-12-21

    sistema que se va a comprar debe estar basado en el n?mero de galones que ser?n utilizados para estos prop?sitos cada d?a. Las unidades t?picas de tratamiento producen de 5 a 15 galones de agua por d?a. En caso de que se nece- siten grandes cantidades de.../gal?n = 0.024 x ???????????? x Costo de electricidad ($/k Wh) Producci?n (galones/d?a) Costos Las unidades de destilaci?n se pueden comprar a un costo de entre $300 y $1,200. Los costos de operaci?n para los sistemas de destilaci?n pueden ser m?s altos que...

  6. Drinking Water Standards (Spanish)

    E-print Network

    Dozier, Monty; McFarland, Mark L.

    2006-04-26

    tratamiento 1 (mg/l) 2 por exposici?n que supere el NMC en el agua potable Salud P?blica QIO Fl?or 4.0 Enfermedades ?seas (dolor y Aditivo para agua para promover 4.0 fragilidad ?sea) Los ni?os podr?an dientes fuertes; erosi?n de dep?sitos sufrir de dientes...- 0.05 Trastornos renales o estomacales Efluentes de f?bricas de qu?micos 0.05 ciclopentadieno QIO Plomo TT 7 ; Beb?s y ni?os: retardo en desarrollo Corrosi?n de ca?er?as en el hogar; cero Nivel de Acci?n = 0.015 f?sico o mental; los ni?os podr...

  7. Grupos españoles de cálculos ab initio de moléculas de interés astrofísico

    NASA Astrophysics Data System (ADS)

    Yáñez, M.

    Pocos campos de la química están tan bien adaptados a la modelización por medio de los métodos teóricos de la Química Cuántica como la Astroquímica y la Química de la Atmósfera, donde las interacciones moleculares son, generalmente, lo suficientemente pequeñas para que el modelo de molécula aislada funcione muy bien. En España son varios los grupos teóricos que dedican su esfuerzo de investigación, o parte de él, al estudio de moléculas o procesos de interés en Astrofísica o en atmósferas planetarias. Presentaremos diferentes ejemplos paradigmáticos de esta actividad en la que se exploran desde aspectos estructurales, hasta aspectos espectroscópicos y dinámicos. Entre los últimos, cabe destacar estudios en los que se demuestra la importancia de procesos a dos estados, prohibidos por espín, en la formación astrofísica de diversos derivados de interés. En el tratamiento espectroscópico se han hecho esfuerzos interesantes, que han aunado teoría y experimento, en el estudio de sistemas relevantes desde el punto de vista atmosférico, como los hidratos de ácido nítrico, o el tratamiento espectroscópico de moléculas no rígidas. No menos interesantes son los estudios de fotoabsorción de radicales o de procesos multifotónicos. Son particularmente abundantes los estudios dedicados a la reactividad específica de sistemas de interés astrofísico o atmosférico, con el objetivo de esclarecer vías de formación de determinados compuestos o de proporcionar mecanismos que permitan identificar las etapas reactivas limitantes de reacciones de interés en esos medios y sobre los que no existía información previa. Así, por ejemplo, se han publicado interesantes estudios sobre la formación o propiedades de compuestos de fósforo, de silico o de azufre o sobre mecanismos de reacción en los que intervienen el ozono, el radical nitrato, el radical OH u otras especies. Finalmente, son también particularmente relevantes los estudios que varios grupos españoles han llevado, y siguen llevando a cabo, sobre sistemas débilmente enlazados, como complejos de Van der Waals o complejos por enlace de hidrógeno, que sin duda juegan un papel importante tanto en medios atmosféricos como interestelares.

  8. The residual and direct effects of reduced-risk and conventional miticides on twospotted spider mites, Tetranychus urticae (Acari: Tetranychidae) and predatory mites (Acari: Phytoseiidae)

    SciTech Connect

    Liburd, O.E.; White, J.C.; Rhodes, E.M. [Department of Entomology and Nematology, University of Florida, Gainesville, FL 32611 (United States); Browdy, A.A. [Department of Food Science and Human Nutrition, University of Florida, Gainesville, FL 32611 (United States)

    2007-03-15

    The residual effects of several reduced-risk and conventional miticides were evaluated in strawberries (Fragaria z ananassa Duchesne) on the twospotted spider mite (TSSM), Tetranychus urticae Koch (Acari: Tetranychidae) and on 2 predatory mites, Neoseiulus californicus McGregor and Phytoseiulus persimilis Athias-Henriot (Acari: Phytoseiidae). Experiments were conducted in the laboratory and greenhouse. The greenhouse experiments also tested the direct effects of the miticides on TSSM. The efficacy of conventional and reduced-risk miticides was evaluated on strawberry leaf discs and on whole plants for control of TSSM. Furthermore, the residual effects of these miticides were evaluated on whole strawberry plants against selective predatory mites. For TSSM, 5 treatments were evaluated: a conventional miticide; fenbutatin-oxide (Vendex[reg]) and 3 reduced-risk miticides; binfenazate (Acramite 50WP[reg]), activated garlic extract (Repel[reg]), sesame seed and castor oil (Wipeout[reg]), and a water-treated control. For predatory mites, the residual effects of only Acramite[reg] and Vendex[reg] were evaluated. Acramite[reg] was the most effective acaricide in reducing TSSM populations in both the laboratory and greenhouse experiments. Vendex[reg] and Wipeout[reg] were also effective in the laboratory, but did not cause significant reduction of TSSM in the greenhouse. Repel[reg] was the least effective of the 4 pesticides evaluated. Neither Acramite[reg] nor Vendex[reg] had a significant effect on either predatory mite species. However, there appeared to be more predatory mites on the Vendex[reg]-treated plants than on the Acramite[reg]-treated plants. There were significantly more predatory mites of both species on the cue plants, which were inoculated with TSSM versus the non-cue plants, which were not inoculated. (author) [Spanish] Los efectos residuales en poblaciones de la 'arana roja', Tetranychus urticae Koch (Acari: Tetranichidae) y de los acaros predadores Neoseiulus californicus McGregor y Phytoseilus persimilis Athias-Henriot (Acari: Phytoseiidae) causados por varios acaricidas convencionales y de riesgo-reducido fueron evaluados en fresas (Fragaria x ananassa Duchense). Los experimentos fueron realizados en laboratorio e invernadero. Los experimentos en el invernadero evaluaron tambien el efecto directo de los acaricidas en la 'arana roja'. La eficacia para controlar la 'arana roja' de los acaricidas convencionales y de riesgo-reducido fue evaluada en discos de las hojas y en plantas de fresa, y los efectos residuales de los acaricidas en los acaros predadores fueron evaluados en plantas completas. Para la 'arana roja' se evaluaron cinco tratamientos: el acaricida convencional fenbutatin-oxido (Vendex[reg]), 3 acaricidas de riesgo-reducido binfenazate (Acaramite 50WP[reg]), extracto de ajo activado (Repel[reg]), aceite de semillas de ajonjoli y ricino (Wipeout[reg]) y un control tratado con agua. Para los acaros predadores solamente los efectos de Acaramite[reg] y Vendex[reg] fueron evaluados. Acaramite[reg] fue el tratamiento mas efectivo para la 'arana roja' en el laboratorio y el invernadero. Vendex[reg] y Wipeout[reg] fueron tambien efectivos en el laboratorio, pero no causaron una reduccion significativa de 'aranas rojas' en el invernadero. Repel[reg] fue el tratamiento evaluado menos eficaz. Ni Acaramite[reg] ni Vendex[reg] redujeron significativamente las poblaciones de acaros predadores. Sin embargo, aparentemente hay mas acaros predadores en Vendex[reg] que en Acaramite[reg]. Tambien se encontraron significativamente mas acaros predadores en plantas inoculadas que en plantas no inoculadas. (author)

  9. Lessons from scaling up a depression treatment program in primary care in Chile.

    PubMed

    Araya, Ricardo; Alvarado, Rubén; Sepúlveda, Rodrigo; Rojas, Graciela

    2012-09-01

    In Chile, the National Depression Detection and Treatment Program (Programa Nacional de Diagnóstico y Tratamiento de la Depresión, PNDTD) in primary care is a rare example of an evidence-based mental health program that was scaled up to the national level in a low- or middle-income country. This retrospective qualitative study aimed to better understand how policymakers made the decision to scale up mental health services to the national level, and to explore the elements, contexts, and processes that facilitated the decision to implement and sustain PNDTD. In-depth semistructured interviews with six key informants selected through intentional sampling were conducted in August-December 2008. Interviewees were senior officers at the Ministry of Health who were directly involved in the decision to scale up the program. Results yielded four elements pivotal to the decisionmaking process: scientific evidence, teamwork and leadership, strategic alliances, and program institutionalization. Each element contributed to building consensus, securing funding, attracting resources, and gaining lasting support from policymakers. Additionally, a review of available documentation led the authors to consider sociopolitical context and use of the media to be important factors. While research evidence for the effectiveness of mental health services in the primary care setting continues to accumulate, low- and middle-income countries should get started on the lengthy process of scaling up by incorporating the elements that led to decisionmaking and implementation of the PNDTD in Chile. PMID:23183564

  10. FACTORES SOCIO-ESTRUCTURALES Y EL ESTIGMA HACIA EL VIH/SIDA: EXPERIENCIAS DE PUERTORRIQUEÑOS/AS CON VIH/SIDA AL ACCEDER SERVICIOS DE SALUD

    PubMed Central

    RIVERA-DIAZ, MARINILDA; VARAS-DIAZ, NELSON; REYES-ESTRADA, MARCOS; SURO, BEATRIZ; CORIANO, DORALIS

    2013-01-01

    RESUMEN El estigma relacionado al VIH/SIDA continúa afectando la prestación de servicios de salud y el bienestar físico y mental de las personas con VIH/SIDA (PVS). Recientemente la literatura científica ha señalado la importancia de comprender las manifestaciones de estigma más allá de las interacciones individuales. Por tal razón, investigaciones recientes en y fuera de Puerto Rico enfatizan la importancia de entender cómo factores socio-estructurales (FSE) influyen en los procesos de estigmatización social. Con el propósito de examinar los FSE que influyen en las manifestaciones de estigma relacionado al VIH/SIDA, realizamos y analizamos nueve grupos focales compuestos por hombres y mujeres en tratamiento para el VIH/SIDA que habían tenido experiencias estigmatizantes. Los participantes identificaron FSE relacionados a las manifestaciones de estigma, tales como el uso de viviendas especializadas, descentralización de los servicios de salud y el desarrollo de protocolos administrativos excluyentes en los servicios de salud. Los resultados demuestran la importancia de considerar los FSE en el desarrollo e implementación de intervenciones dirigidas a la población. PMID:24639599

  11. Sobre el estado evolutivo de ? Pictoris

    NASA Astrophysics Data System (ADS)

    Brunini, A.; Benvenuto, O. G.

    Desde el descubrimiento de fuertes excesos infrarrojos en ? Pictoris, esta estrella ha sido muy estudiada y es considerada candidata a poseer un sistema planetario propio. ? Pic está rodeada de un disco asimétrico de polvo que se observa de canto y que esta vacío a distancias <= 40 AU. Esto se considera una fuerte evidencia en favor de la presencia de (al menos) un planeta gigante. Recientemente se han observado líneas de material circunestelar que se han interpretado como consecuencia de la caída de objetos cometarios sobre esta estrella. Recientemente se ha utilizado la existencia del disco de polvo para atribuir una edad corta (pre - secuencia principal) a ?Pic. Sin embargo, la evaporación de estos cometas provee suficiente polvo como para explicar la presencia del disco observado sin necesidad de edades cortas. En este trabajo mostramos que la comparación entre la tasa de impactos cometarios estimada en el Sistema Solar para diferentes etapas de su evolución y los datos observados en ? Pic indica edades avanzadas para ? Pic. Esta estimación debe tomarse con cautela ya que depende de la estructura de los sistemas planetarios. Además mostramos que, desde el punto de vista de la evolución estelar y con las incertezas presentes en la luminosidad y la temperatura efectiva, existe un continuo de edades posible para ? Pic. Sin embargo, empleando los datos provenientes de los flujos cometarios encontramos que una edad prolongada es consistente con ambos tratamientos.

  12. Esquizofrenia y trastorno en el consumo de sustancias: prevalencia y characterísticas sociodemográficas en la población Latina

    PubMed Central

    Jiménez-Castro, Lorena; Raventós-Vorst, Henriette; Escamilla, Michael

    2012-01-01

    El interés por comprender la co-morbilidad de la esquizofrenia y el trastorno en el uso de sustancias, ha aumentado debido al incremento de este diagnóstico, a los efectos negativos observados en el sujeto y a los costos en los servicios de salud. Este trastorno dual puede tener efectos dramáticos en el curso clínico del trastorno psicótico tales como: mayores recaídas, re-hospitalizaciones, síntomas más severos, no adherencia al tratamiento antipsicótico, cambios marcados del humor, aumento en el grado de hostilidad e ideación suicida, así como alteraciones en otras áreas del funcionamiento incluyendo violencia, victimización, indigencia y problemas legales. La literatura proveniente en particular de Estados Unidos y Europa sugiere que el rango de prevalencia para este diagnóstico puede oscilar entre el 10% hasta el 70%. En este estudio, revisamos la prevalencia del diagnóstico dual de esquizofrenia y trastorno en el uso sustancias, así como sus características sociodemográficas, con base en la literatura disponible alrededor del mundo dando énfasis en la poblacion latina. A pesar de que este diagnóstico es ampliamente aceptado, se conoce poco sobre su prevalencia en la población latina, sobre los factores ambientales, demográficos, clínicos y otras características de estos individuos. Un mejor conocimiento sobre este diagnóstico permitiría mejorar los métodos para la detección y adecuada valoración del trastorno en el uso de sustancias en personas con trastornos metales severos como la esquizofrenia. PMID:21404151

  13. DISYUNTIVAS EN LAS CONCEPCIONES SOBRE AUTONOMÍA Y BENEFICENCIA QUE AFECTAN LA TERAPÉUTICA DEL INTENTO SUICIDA1

    PubMed Central

    Mondragón, Liliana; Monroy, Zuraya; Ito, Ma. Emily; Medina-Mora, Dra. Ma. Elena

    2010-01-01

    El objetivo del trabajo es conocer las disyuntivas entre los principios de beneficencia y autonomía, que se presentan en la relación médico-paciente, durante la terapéutica del intento de suicidio. La investigación se realizó en dos hospitales psiquiátricos de la Ciudad de México. La muestra incluyó a tres sujetos con intento de suicidio, mayores de 18 años, que eran atendidos en consulta externa a causa de una lesión autoinfligida en el último año, y a tres psiquiatras que trataban a estos pacientes. La información se obtuvo previo consentimiento informado en entrevistas individuales. Se llevó a cabo un análisis de discurso argumentado para encontrar los significados que los participantes otorgaron a los principios bioéticos y las posibles disyuntivas entre éstos. Las discordancias entre la beneficencia y la autonomía estuvieron relacionadas con el beneficio del tratamiento, el respeto por los valores y las creencias de los pacientes, entre otros. Este trabajo presenta consideraciones éticas relevantes en el escenario clínico, al ofrecer al psiquiatra un análisis bioético que le permita actuar de acuerdo con la beneficencia y respetando la autonomía del paciente frente a casos de intento de suicidio y, de esta forma procurar una mejor atención para ellos. PMID:20830214

  14. Life Course Experiences, Pain and Suffering: A Case Study of an Older Mexican American Woman with Mobility Impairment

    PubMed Central

    Walker, Janiece L.; Harrison, Tracie C.; Hendrickson, Sherry G.

    2012-01-01

    There is a dearth of literature examining how adversity shapes the experiences of pain and/or suffering in a middle aged Mexican American women. The purpose of this qualitative descriptive study was to understand pain and suffering from a life course perspective as described by a Mexican American woman aging with early onset mobility impairment. This Hispanic woman experienced episodes of abuse and rejection over the life course, which may have significantly influenced her pain and suffering experience in adulthood. This adds to the literature on how adversity influences later life pain experience and provides insight on why pharmacological treatment alone may not be as successful as a holistic intervention. Hay escasez de literatura que examine cómo la adversidad da forma a las experiencias de dolor y / o sufrimiento en mujeres mexicana-americana mayores de edad. El propósito de este estudio descriptivo cualitativo fue comprender el dolor y el sufrimiento desde una perspectiva de ciclo de vida como descrito por una mujer mexicana-americana envejeciendo con inicio temprano de deterioro de movilidad. Esta Latina experimentó episodios de maltrato y rechazo, que se percibió haber afectado su experiencia de dolor y sufrimiento luego como adulta. Este estudio aumenta la literatura sobre cómo la adversidad influya la experiencia de dolor más tarde en la vida, y nos permite comprender mejor como el tratamiento farmacológico por sí solo no es tan exitoso como pueda ser una intervención integral. PMID:24830728

  15. Reacciones de intercambio de carga

    NASA Astrophysics Data System (ADS)

    Errea, L. F.

    Se discute la validez de diversas metodologías y su aplicación al estudio de procesos de intercambio de carga electrónico entre iones y blancos atómicos y moleculares. Para energías de impacto entre 0.05 y 5 eV / amu se emplea el método cuántico de la Coordenada de Reacción Común (CRC). A mayores energías, se utiliza el método semiclásico iconal con un desarrollo de la función de onda dinámica en estados moleculares adiabáticos, modificados con un factor de traslación común (FTC). Estos estados pueden obtenerse con cálculos ab initio o empleando potenciales modelo. Cuando la ionización compite con la transferencia de carga, la inclusión de pseudoestados en estos desarrollos permite calcular simultáneamente las secciones eficaces de ambos procesos. Otra técnica utilizada es el método estadístico CTMC. En el tratamiento de colisiones ión-molécula (diatómica) contrastamos la aplicabilidad de distintos métodos, desde la llamada aproximación Franck-Condon hasta un desarrollo en estados vibrónicos, pasando por la aproximación súbita vibro-rotacional, obteniéndose secciones eficaces de captura electrónica total y a estados individuales, así como secciones de excitación vibracional a estados ligados y del continuo (disociación). En todos los casos es necesario calcular superficies de energía y los correspondientes acoplamientos dinámicos entre los estados. La aplicación de estos métodos permite determinar el grado de contaminación de los haces por estados metaestables en un experimento dado, el cambio en los resultados con diferentes isótopos, la importancia de procesos de doble captura, seguida de explosión culombiana, todo ello con precisión comparable a la de medidas experimentales, para sistemas de interés en distintos tipos de plasmas.

  16. Regulando la Enfermedad a través de la Definición y la Restricción: Profesionales de la Salud Hablan sobre el VIH/SIDA1

    PubMed Central

    Rivera, Souhail Malavé; Díaz, Nelson Varas

    2009-01-01

    Resumen Las profesiones de la salud tienen un papel social dual. Por un lado, velan por el mantenimiento de la salud de la población protegiendo el bien común. Por el otro, dictaminan las formas saludables, y por lo tanto socialmente apropiadas, de ser, actuar y pensar. Este último papel, está más ligado al control social de la población que a una preocupación altruista hacia la misma. A través de esta supervisión y control, se construyen los sujetos a los cuales todos/as debemos aspirar a ser para gozar de aceptación social. Los/as profesionales de la salud han jugado un rol protagónico en dicho proceso, siendo los agentes que delimitan y definen lo que es enfermo vs. saludable, útil vs. inútil, apropiado vs. inapropiado. En el caso de la epidemia del VIH, este esfuerzo se ha hecho cada vez más vigente ya que estos/as profesionales juegan un papel importante en el tratamiento de las personas que viven con VIH/SIDA (PVVS). Sin embargo, su función está plasmada de definiciones que sirven para criminalizar a las PVVS. El objetivo de este estudio fue explorar la manera en que una muestra de profesionales de la salud en Puerto Rico construyen a las PVVS. Con este propósito, entrevistamos 80 profesionales de la salud y estudiantes de estas profesiones. Estas entrevistas fueron grabadas, transcritas y sometidas a un análisis de discurso. Los resultados reflejaron que según las personas participantes: 1) la PVVS no es una persona “normal” o funcional bajo los estándares sociales debido a que su salud no se los permite, 2) representa una carga para la sociedad incluyendo familiares, amigos/as, el mundo del trabajo, e incluso para el gobierno, 3) debe ser vigilada porque representa un riesgo para la persona seronegativa que es descrita como saludable y productiva, y 4) necesita que su salud y conducta sexual sean controladas por vía legal y/o por las personas que representan las instituciones sociales, como lo son los/as profesionales de la salud. En este artículo abordamos el potencial rol de la psicología para servir como vehículo de reconstrucción de dichas nociones, tomando en consideración su propio rol en la formación y mantenimiento de dicho sujeto socialmente deseable. PMID:22025907

  17. Progress in the prognosis of adult Hodgkin's lymphoma in the past 35 years through clinical trials in Argentina: a GATLA experience.

    PubMed

    Pavlovsky, Santiago; Lastiri, Francisco

    2004-09-01

    The purpose of this study was to evaluate the trends in complete remission (CR) rate, disease-free survival (DFS), and overall survival (OS) through 35 years of Grupo Argentino de Tratamiento de la Leucemia Aguda (GATLA) clinical trials. A total of 1,254 adult patients with Hodgkin's Lymphoma were evaluated according to seven consecutive protocols. This 35-year study was divided into three phases. The patients in the first phase (1968-1985) were treated with CVPP (cyclophosphamide/vinblastine/procarbazine/prednisone) plus involved-field radiotherapy (IFRT). In the CVPP regimen, cyclophosphamide and vinblastine were administered intravenously on day 1 and prednisone and procarbazine were administered orally on days 1-14 every 28 days. The second phase (1986-1996) used mainly reinforced CVPP with cyclophosphamide and vinblastine on days 1-8 plus IFRT. The third phase (1997-2003) used ABVD(doxorubicin/bleomycin/vinblastine/dacarbazine) plus IFRT. In clinical stage I/II, the CR rate was 86% in 252 patients treated in the first phase and DFS and OS were 57% and 78% at 5 years and 50% and 71% at 10 years. The second phase had 148 patients with clinical stage I/II disease, and the CR rate was 91%, 5-year DFS and OS were 78% and 90%, and 10-year DFS and OS were 70% and 83%. The third phase had 182 patients with clinical stage I/II disease, and the CR rate was 95%, 5-year DFS and OS were 87% and 96%, and 10-year DFS and OS were not reached. The statistical difference was P = 0.016 in terms of CR and P < 0.001 in terms of DFS and OS. In the first phase of 394 patients with clinical stage III/IV disease, the CR rate was 71%, DFS and OS at 5 years were 37% and 62%, and DFS and OS at 10 years were 32% and 53%. In the second phase of 164 patients with clinical stage III/IV disease, the CR rate was 84%, DFS and OS at 5 years were 66% and 80%, and DFS and OS at 10 years were 60% and 75%. In the third phase of 114 patients with clinical stage III/IV disease, the CR rate was 88% and DFS and OS at 5 years were 60% and 90%. The DFS and OS were not reached at 10 years. The differences among the 3 phases in CR, DFS and OS were highly significant (P < 0.001). PMID:15453925

  18. Capture-zone design in an aquifer influenced by cyclic fluctuations in hydraulic gradients

    NASA Astrophysics Data System (ADS)

    Zawadzki, Willy; Chorley, Don; Patrick, Guy

    2002-10-01

    Design of a groundwater pumping and treatment system for a wood-treatment facility adjacent to the tidally influenced Fraser River estuary required the development of methodologies to account for cyclic variations in hydraulic gradients. Design of such systems must consider the effects of these cyclic fluctuations on the capture of dissolved-phase contaminants. When the period of the cyclic fluctuation is much less than the travel time of the dissolved contaminant from the source to the discharge point, the hydraulic-gradient variations resulting from these cycles can be ignored. Capture zones are then designed based on the average hydraulic gradient determined using filter techniques on continuous groundwater-level measurements. When the period of cyclic fluctuation in hydraulic gradient is near to or greater than the contaminant travel time, the resulting hydraulic-gradient variations cannot be ignored. In these instances, procedures are developed to account for these fluctuations in the capture-zone design. These include proper characterization of the groundwater regime, assessment of the average travel time and period of the cyclic fluctuations, and numerical techniques which allow accounting for the cyclic fluctuations in the design of the capture zone. Résumé. L'étude d'un système de pompage et de traitement de l'eau souterraine d'une usine de traitement du bois proche de l'estuaire de la rivière Fraser, influencé par les marées, a nécessité la mise au point de méthodologies pour prendre en compte les variations cycliques de gradients hydrauliques. L'étude de tels systèmes doit considérer les effets de ces variations cycliques sur l'extraction des contaminants en phase dissoute. Lorsque la période des variations cycliques est très inférieure au temps de parcours du contaminant dissous entre la source et le point d'émergence, les variations du gradient hydraulique résultant de ces cycles peuvent être ignorées. Les zones d'extraction sont alors réalisées sur la base du gradient hydraulique moyen déterminé au moyen de techniques de filtrage sur des mesures continues de la piézométrie. Lorsque la période de la fluctuation cyclique dans le gradient hydraulique est proche de ou supérieure au temps de parcours du contaminant, les variations résultantes de gradient hydraulique ne peuvent plus être ignorées. Dans ces cas-là, des procédures ont été mises au point pour prendre en compte ces fluctuations dans la conception de la zone d'extraction. Celles-ci prennent en considération la caractérisation propre du régime de la nappe, l'évaluation du temps de parcours moyen et de la période des fluctuations cycliques, et des techniques numériques qui permettent de considérer les fluctuations cycliques dans la conception de la zone d'extraction. Resumen. El diseño de un sistema de bombeo y tratamiento de aguas subterráneas para una instalación de manufactura de madera que está próxima al estuario del río Fraser, sometido a la influencia de las mareas, ha requerido el desarrollo de metodologías para tener en cuenta las variaciones cíclicas de los gradientes hidráulicos. El diseño de tales sistemas debe considerar los efectos de las fluctuaciones cíclicas en la captura de contaminantes en fase disuelta. Cuando el período de la fluctuación cíclica es mucho menor que el tiempo de tránsito del contaminante disuelto entre el punto de entrada y el de descarga, se puede ignorar las variaciones del gradiente hidráulico provocadas por dichos ciclos. Las zonas de captura se diseñan entonces en función del gradiente hidráulico promedio, que se determina mediante técnicas de filtrado de medidas continuas del nivel piezométrico. Cuando el período de la fluctuación cíclica del gradiente hidráulico es comparable o mayor que el tiempo de tránsito del contaminante, no puede ignorarse las variaciones resultantes en el gradiente hidráulico. En ese caso, se tiene que desarrollar procedimientos para contar con las fluctuaciones en el diseño de las zonas de captura. Ello implica una ad

  19. Breakfast of champions or kiss of death? Survival and sexual performance of protein-fed, sterile Mediterranean fruit flies (Diptera: Tephritidae)

    SciTech Connect

    Yuval, B.; Maor, M.; Levy, K. [Dept. of Entomology, Hebrew University, PO 12, Rehovot, 76100 (Israel); Kaspi, R. [Dept. of Entomology, University of California, Davis CA 95616 (United States); Taylor, P. [Dept. of Psychology, Macquarie University, NSW 2109 (Australia); Shelly, T. [USDA-APHIS, 41-650 Ahiki Street, Waimanalo, HI 96795 (United States)

    2007-03-15

    The sterile insect technique (SIT) is increasingly being used around the world to control Ceratitis capitata (Wiedemann) (Diptera: Tephritidae), the Mediterranean fruit fly as part of an area-wide integrated approach. One option that may improve the effectiveness of the SIT, by increasing the sexual competitiveness of released sterile males, consists of feeding males protein during the post-teneral stage, a diet that increases sexual performance of wild males. We examine the effects of diet on the successive hurdles males must overcome in order to inseminate females, i.e., joining leks, copulating females, having their sperm stored and inhibition of female remating. In addition, we address the effects of diet on post-release foraging success, longevity, and the ability to withstand starvation. While protein feeding universally increases the sexual success of wild males, its effect on sterile males varies with strain, experimental settings, and environmental conditions. In some cases, treatments that resulted in the best sexual performance were significantly associated with increased vulnerability to starvation. However, no particular diet affected the ability of sterile males to find nutrients in the field when these where available. We suggest it may be better to release relatively short-lived flies that are highly competitive, rather than long-lived, sexually ineffective ones. (author) [Spanish] El uso de la tecnica de insecto esteril (TIE) esta aumentando alrededor del mundo para el control de Ceratitis capitata (Wiedemann) (Diptera: Tephritidae), la mosca mediterranea de la fruta como parte de un enfoque integrado por toda el area. Una opcion que puede mejorar la eficiencia de TIE, por medio del aumento de la capacidad de los machos esteriles liberados para competir, consiste en la alimentacion de los machos con proteina durante la etapa de pos-teneral, una dieta que aumenta el desempeno sexual de los machos naturales. Nosotros examinamos los efectos de la dieta sobre los obstaculos sucesivos que los machos tienen que superar para inseminar las hembras, i.e., unir con otros machos en areas para el apareamiento, copula de las hembras, almacenar esperma e inhibir el re-apareamiento de hembras. Ademas discutimos los efectos de la dieta sobre el exito de su actividad forrajera despues de ser liberados, la longevidad y la habilidad para aguantar la inanicion. Mientras que la alimentacion con proteina universalmente aumentan el exito sexual de los machos naturales, su efecto sobre los machos esteriles varia segun la raza, el lugar de los experimentos y las condiciones ambientales. En algunos casos, los tratamientos que resultaron con mejor desempeno sexual fueron asociados significativamente con el aumento de la vulnerabilidad a la inanicion. Sin embargo, ninguna dieta en particular afecto la habilidad de los machos esteriles para encontrar nutrientes en el campo cuando fueron disponibles. Nosotros sugerimos que puede ser mejor el liberar moscas que tienen una vida relativamente corta y que son mas competidoras, en vez de moscas que tienen una vida larga y sexualmente inefectiva. (author)

  20. Impact of Chloroquine on Viral Load in Breast Milk

    PubMed Central

    Semrau, Katherine; Kuhn, Louise; Kasonde, Prisca; Sinkala, Moses; Kankasa, Chipepo; Shutes, Erin; Vwalika, Cheswa; Ghosh, Mrinal; Aldrovandi, Grace; Thea, Donald M.

    2006-01-01

    Summary The anti-malarial agent chloroquine has activity against HIV. We compared the effect of chloroquine (n = 18) to an anti-malarial agent without known anti-HIV-activity, sulfadoxine-pyrimethamine (n = 12), on breast milk HIV RNA levels among HIV-infected breastfeeding women in Zambia. After adjusting for CD4 count and plasma viral load, chloroquine was associated with a trend towards lower levels of HIV RNA in breast milk compared with sulfadoxine-pyrimethamine (P 0.05). Higher breastmilk viral load was also observed among women receiving presumptive treatment = for symptomatic malaria compared with asymptomatic controls and among controls reporting fever in the prior week. Further research is needed to determine the potential role of chloroquine in prevention of HIV transmission through breastfeeding. Impacte de la chloroquine sur la charge virale dans le lait maternelle La chloroquine, agent antimalarique, a une activité contre le VIH. Nous avons comparé l’effet de la chloroquine à celui d’un autre agent antimalarique, la sulfadoxine-pyrimethamine, dont l’activité sur le VIH n’est pas connue, en mesurant les taux d’ARN de VIH dans le lait maternel de femmes allaitantes infectées par le VIH en Zambie. Après ajustement pour les taux de CD4 et la charge virale dans le plasma, la chloroquine comparée à la sulfadoxine pyrimethamine était associée à une tendance vers des teneurs plus bas en ARN de VIH dans le lait maternel (P = 0,05). Des charges virales plus élevées dans le lait maternel étaient aussi observées chez des femmes recevant un traitement présomptif pour des symptômes de malaria par rapport aux contrôles asymptomatiques et par rapport à des contrôles rapportant de la fièvre durant la première semaine. Des études supplémentaires sont nécessaires pour déterminer le rôle potentiel de la chloroquine dans la prévention de la transmission du VIH par l’allaitement maternel. mots clésVIH, malaria, allaitement maternel, chloroquine, sulfadoxine-pyrimethamine, charge virale du lait maternel, fièvre Impacto de la cloroquina en la carga viral de la leche materna El antimalárico cloroquina tiene actividad frente al VIH. Comparamos el efecto de la cloroquina (n = 18) frente a un antimalárico sin actividad anti-VIH conocida, la sulfadoxina-pirimetamina (n = 12), en los niveles de ARN en la leche materna de mujeres infectadas con VIH, en Zambia. Después de ajustar para recuento de CD4 y la carga viral en plasma, se asoció a la cloroquina con una tendencia hacia menores niveles de ARN del VIH en leche materna, comparado con la sulfadoxina pirimetamina (P = 0.05). También se observó una mayor carga viral en la leche materna de mujeres recibiendo tratamiento presuntivo para malaria sintomática, que en los controles asintomáticos y controles que habáan reportado fiebre la semana anterior. Es necesario realizar más estudios para determinar el papel potencial de la cloroquina en la prevención de la trasmisión de VIH a través de la lactancia materna. palabras claveVIH, malaria, lactancia materna, cloroquina, sulfadoxina pirimetamina, transmisión vertical, leche materna, carga viral, fiebre PMID:16772000