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Pectus excavatum  


Pectus excavatum is a congenital (present at birth) abnormality that can be mild or severe. It usually develops during pregnancy. It is caused by too much growth of the connective tissue that joins the ribs to the breastbone. This causes the sternum to ...


Xiphoid horn in pectus excavatum  

Microsoft Academic Search

In pectus excavatum there may be a cartilaginous horn on the inner surface of the xiphoid process rubbing on the heart, or the xiphoid process may be tipped inward, rubbing on the heart and causing anginoid pain. Being cartilaginous, these protrusions of the xiphoid cartilage are not visible on preoperative radiographs. Eight per cent of pectus excavatum patients have organic

Edward F. Skinner



Surgical repair of pectus excavatum and carinatum.  


The author discusses different forms of pectus deformities and presents appropriate surgical methods he developed for their correction. For pectus excavatum, the surgical technique includes conservative sub-perichondral resection of deformed costal cartilages and detachment of the xiphoid process. A transverse sternotomy is performed at the upper level of the deformed sternum, which is then bent forward. The corrected sternal position is secured by a "hammock" of synthetic mesh, spread behind the sternum, and attached to the respective cartilage remnants. The pectoralis muscles are then united presternally. The initial steps of pectus carinatum correction are similar to that of pectus excavatum. The sternum, however, is not freed of its environment. A length of 3-4 cm is resected from the distal sternum and the xiphoid process is reattached in the proper anatomical direction. Measures to correct different anatomical varieties, such as pouter pigeon breast, asymmetrical pectus excavatum, and carinatum, are discussed individually. PMID:19632565

Robicsek, Francis; Watts, Larry T; Fokin, Alexander A



Pulmonary embolism: a late complication of pectus excavatum repair.  


The Ravitch operation is frequently performed to correct pectus excavatum with few and minor complications. We present a case of pulmonary embolism with pulmonary endarterectomy in a patient undergoing Ravitch repair for pectus excavatum 2 years ago. PMID:23721082

Abaci, Okay; Cetinkal, Gokhan; Kocas, Cuneyt; Evren, Emre; Yildiz, Mustafa; Yildizeli, Bedrettin; Yanarta?, Mehmet



Pectus tunneloscopy: making Nuss procedure for pectus excavatum safe  

PubMed Central

OBJECTIVES The Nuss procedure for pectus excavatum involves the risk of cardiac injury during the creation of the retrosternal tunnel and during bar introduction or removal across the tunnel. A modified novel real-time technique for the safe introduction of the Nuss bar across the crucial retrosternal tunnel blind spot during introduction and removal is described. METHODS In 2012, we devised a technique for real-time endovision-guided introduction of the Nuss bar called pectus tunneloscopy. Between February 2012 and December 2012, 6 patients with pectus excavatum had their bar introduced across the tunnel using this technique. RESULTS This technique provided safe introduction and removal of the bar during the multiple times the bar is remodelled before final fixation. CONCLUSIONS Pectus tunneloscopy is a real-time endovision surgical technique, providing safe introduction of the bar across the crucial retrosternal tunnel blind spot. PMID:23660736

Darlong, Laleng M.



Correction of pectus excavatum with breast hypoplasia using simultaneous pectus bar procedure and augmentation mammoplasty.  


Most women with asymmetric pectus excavatum suffer from hypoplastic breasts. Hence, aesthetic correction of pectus excavatum has to address thoracic wall deformity, breast hypoplasia, and asymmetry.In retrospective series, 21 patients with a diagnosis of pectus excavatum with hypoplastic breasts were corrected using the pectus bar procedure and subpectoral augmentation mammoplasty. Results were assessed by analyzing prospectively collected data and calculating pectus indices from computed tomographic scans. At 12 months postoperatively, cosmetic evaluations were performed by the patients and by an independent, board-certified plastic surgeon using score from 0 (very poor) to 4 (very good).Cosmetic results evaluated by plastic surgeon were good (3.33 ± 0.03) and patient satisfaction was high (3.52 ± 0.03). Furthermore, indices of pectus excavatum were corrected to near normal.The authors consider that the pectus bar procedure with subpectoral augmentation mammoplasty is useful for the aesthetic correction of pectus excavatum with hypoplastic breasts. PMID:23486122

Park, Hyung Joo; Gu, Ja Hea; Jang, Joon Chul; Dhong, Eun-Sang; Yoon, Eul-Sik



Surgical Repair of Pectus Excavatum Markedly Improves Body Image and Perceived Ability for Physical Activity: Multicenter Study  

Microsoft Academic Search

OBJECTIVE. This study evaluated changes in both physical and psychosocial quality of life reported by the parent and child after surgical repair of pectus excavatum. METHODS. As part of a multicenter study of pectus excavatum, a previously validated tool called the Pectus Excavatum Evaluation Questionnaire was administered by the research coordinator, via telephone, to parents and patients (8 -21 years

Robert E. Kelly; Thomas F. Cash; Robert C. Shamberger; Karen K. Mitchell; Robert B. Mellins; M. Louise Lawson; Richard G. Azizkhan; Andre V. Hebra; Donald Nuss; Michael J. Goretsky; Ronald J. Sharp; George W. Holcomb; Walton K. T. Shim; Stephen M. Megison; R. Lawrence Moss; Annie H. Fecteau; Paul M. Colombani; Traci Bagley; Amy Quinn; Alan B. Moskowitz



Pectus excavatum (funnel chest): a historical and current prospective.  


Pectus excavatum (PE) is a relatively common deformity involving the anterior chest wall. It is represented clinically as a conical depression of the sternum and costal cartilages with the apex at the xiphoid process. Associated features and symptoms vary but generally involve respiratory and cardiac abnormalities. Since it's initial description, numerous surgical techniques have been developed to correct PE, with the Ravtich (open) and Nuss (minimally invasive) procedures being the most commonly employed. Although the etiology remains unclear, the pathogenesis of PE is currently thought to involve the overgrowth of the costochondral region of the ribs. In addition, documented case reports of familial pectus excavatum exist, suggesting a heritable form of the defect. Numerous genetic markers have also been discovered, linking PE to various genetic syndromes. PMID:22323132

Dean, Chase; Etienne, Denzil; Hindson, David; Matusz, Petru; Tubbs, R Shane; Loukas, Marios



Positional hyperventilation-induced hypoxaemia in pectus excavatum  

Microsoft Academic Search

The presented case is of a young male (aged 19 yrs) with a pectus excavatum who showed significant exercise intolerance, despite normal pulmonary function at rest, including carbon monoxide diffusing capacity. Clinical exercise testing led to a strong suspicion of a right- to-left shunt due to an abnormally wide alveolo-arterial oxygen gradient (26.4 kPa) at peak oxygen uptake, with severe

B. Wallaert; B. Cavestri; C. Fournier; R. Neviere; B. Aguilaniu; Physiologie Clinique



Pectus excavatum: uncommon electrical abnormalities caused by extrinsic right ventricular compression.  


We report a case of pectus excavatum associated with ventricular tachycardia provoked by exercise in a 19-year-old man. Although this chest deformity has been associated with supraventricular dysrhythmias, documented ventricular tachycardia has only been reported once. Our patient's ventricular dysrhythmia was treated by surgical correction of his pectus excavatum only, and at 3 years follow-up he has had no recurrence of his ventricular tachycardia. PMID:24303874

Chan Wah Hak, Yee-Sen; Lim, Yeong-Phang; Liew, Reginald; Hsu, Li-Fern



Metal allergy to titanium bars after the Nuss procedure for pectus excavatum.  


The Nuss procedure requires the placement of metal bars in the chest cage to repair pectus excavatum. Metal allergies are one of the complications associated with this procedure. Given that titanium is a biocompatible metal, it induces few allergic symptoms. Therefore, titanium bars are recommended for patients with metal sensitivity. We report the case of a 17-year-old boy with pectus excavatum who had a metal allergy to titanium bars, which occurred after the Nuss procedure. The administration of oral steroids is useful for treating metal allergies. Metal allergies to titanium bars are very rare; however, they can still occur. PMID:25087797

Sakamoto, Kazuhiro; Ando, Kohei; Noma, Daisuke



Correction of pectus excavatum and pectus carinatum assisted by the endoscope.  


Six patients with pectus excavatum and two patients with pectus carinatum had their conditions corrected by a partial costal cartilage resection with a sternal osteotomy through a 2.5-cm to 4-cm skin incision located just above the xyphoid process assisted by an endoscope. In addition to the incision, stab wounds of less than 3 mm in diameter were also made, in some cases, for insertion of the surgical instruments to facilitate the operation. The ribs and rib cartilages were exposed beyond the affected area through a prexyphoid incision under endoscopic control. The mobility of the skin incision site was thus enhanced, and it was possible to perform most of the subperichondrial partial costal cartilage resection under direct visualization. The pleura was freed from the sternum under endoscopic visualization. The advantages of this technique include minimal operative scars and the ability to free the pleura from the sternum under endoscopically magnified visualization, which prevents rupturing of the pleura in the retrosternal area. PMID:9091900

Kobayashi, S; Yoza, S; Komuro, Y; Sakai, Y; Ohmori, K



Early and Long-Term Results of Surgical Repair of Pectus Excavatum  

Microsoft Academic Search

From 1990 to 1998, 30 patients underwent surgery for correction of pectus excavatum. There were 19 (63%) males and 11 (37%) females, aged 4 to 32 years (mean, 12.57 years). Bilateral excision of 4 to 6 costal cartilages and sternal wedge osteotomy were performed on 27 (90%) patients, and Kirschner wires were used for substernal support in 25 (83%). A

Abdullah Erdog; Arife Ayten; Necdet Öz; Abid Demircan


Outcome analysis of minimally invasive repair of pectus excavatum: Review of 251 cases  

Microsoft Academic Search

Background\\/Purpose: Since the first report in 1997 by Dr Nuss of the technique for minimally invasive repair of pectus excavatum (MIRPE), the popularity and demand for this operation has increased dramatically. Many pediatric surgeons became familiarized with MIRPE and have applied it to a large number of patients. Outcomes and complications have not yet been defined.Methods: A comprehensive survey of

André Hebra; Barbara Swoveland; Michael Egbert; Edward P. Tagge; Keith Georgeson; H. Biemann Othersen; Donald Nuss



Asymmetric Pectus Excavatum Is Associated with Overgrowth of Ribs Rather Than Cartilage.  


Background?To evaluate whether the overgrowth of costal cartilage exists in patients with pectus excavatum, we compared the length of the costal cartilage and ribs between patients with asymmetric pectus excavatum and controls without chest wall deformity using three-dimensional computed tomography. Materials and Methods?Nineteen adult patients with asymmetric pectus excavatum and 19 age and sex matched controls without chest wall deformity were enrolled. We measured the full lengths of the fourth to sixth ribs and costal cartilage using three-dimensional volume-rendered computed tomography images and curved multiplanar reformatting techniques. The lengths of ribs and costal cartilage, their summations, and the costal index ([length of cartilage/length of rib]?×?100 [%]) were compared on the asymmetrically depressed side of patients (Group A), the opposite side of the same patients (Group B), and controls (Group C) at the fourth to sixth levels. Results?The lengths of the ribs of groups A and B were significantly longer (p??0.05) among the three groups (53.1?±?7.3?mm vs. 54.6?±?8.6?mm vs. 52.9?±?5.2 at the fourth level, 71.9?±?9.6?mm vs. 72.3?±?9.9?mm vs. 69.2?±?7.1?mm at the fifth level, and 100.1?±?15.2?mm vs. 104.2?±?15.8?mm vs. 99.1?±?9.1?mm at sixth level). The summations of the rib and costal cartilage lengths were longer in groups A and B than in group C. The costal indices were not different among the three groups at the fourth, fifth, and sixth rib levels. Conclusion?In patients who had asymmetric pectus excavatum with a???21-degree angle of sternal rotations, the ribs but not the costal cartilage were longer than those of controls. These findings suggest that cartilage overgrowth is not the main factor responsible for asymmetric pectus excavatum, and it could instead be related to abnormal rib growth. PMID:25387463

Park, Chul Hwan; Kim, Tae Hoon; Haam, Seok Jin; Lee, Sungsoo



When it is not an infection: metal allergy after the Nuss procedure for repair of pectus excavatum  

Microsoft Academic Search

Purpose: Increasing use of implantable bars for minimally invasive pectus excavatum repair has introduced metal allergy (nickel and chromium) to pediatric surgeons. Metal allergy is a well-recognized entity in neurologic, orthopedic, and craniofacial surgery. This study was performed to evaluate metal allergy and its effects on treatment with the Nuss procedure in 862 patients. Methods: After institutional review board approval,

Gregory D. Rushing; Michael J. Goretsky; Tina Gustin; Maripaz Morales; Robert E. Kelly; Donald Nuss


Artificial neural networks for automatic modelling of the pectus excavatum corrective prosthesis  

NASA Astrophysics Data System (ADS)

Pectus excavatum is the most common deformity of the thorax and usually comprises Computed Tomography (CT) examination for pre-operative diagnosis. Aiming at the elimination of the high amounts of CT radiation exposure, this work presents a new methodology for the replacement of CT by a laser scanner (radiation-free) in the treatment of pectus excavatum using personally modeled prosthesis. The complete elimination of CT involves the determination of ribs external outline, at the maximum sternum depression point for prosthesis placement, based on chest wall skin surface information, acquired by a laser scanner. The developed solution resorts to artificial neural networks trained with data vectors from 165 patients. Scaled Conjugate Gradient, Levenberg-Marquardt, Resilient Back propagation and One Step Secant gradient learning algorithms were used. The training procedure was performed using the soft tissue thicknesses, determined using image processing techniques that automatically segment the skin and rib cage. The developed solution was then used to determine the ribs outline in data from 20 patient scanners. Tests revealed that ribs position can be estimated with an average error of about 6.82+/-5.7 mm for the left and right side of the patient. Such an error range is well below current prosthesis manual modeling (11.7+/-4.01 mm) even without CT imagiology, indicating a considerable step forward towards CT replacement by a 3D scanner for prosthesis personalization.

Rodrigues, Pedro L.; Moreira, António H. J.; Rodrigues, Nuno F.; Pinho, ACM; Fonseca, Jaime C.; Correia-Pinto, Jorge; Vilaça, João. L.



Systematic review of surgical treatment techniques for adult and pediatric patients with pectus excavatum  

PubMed Central

This compares outcome measures of current pectus excavatum (PEx) treatments, namely the Nuss and Ravitch procedures, in pediatric and adult patients. Original investigations that stratified PEx patients based on current treatment and age (pediatric?=?0–21; adult 17–99) were considered for inclusion. Outcome measures were: operation duration, analgesia duration, blood loss, length of stay (LOS), outcome ratings, complications, and percentage requiring reoperations. Adult implant patients (18.8%) had higher reoperation rates than adult Nuss or Ravitch patients (5.3% and 3.3% respectively). Adult Nuss patients had longer LOS (7.3 days), more strut/bar displacement (6.1%), and more epidural analgesia (3 days) than adult Ravitch patients (2.9 days, 0%, 0 days). Excluding pectus bar and strut displacements, pediatric and adult Nuss patients tended to have higher complication rates (pediatric - 38%; adult - 21%) compared to pediatric and adult Ravitch patients (12.5%; 8%). Pediatric Ravitch patients clearly had more strut displacements than adult Ravitch patients (0% and 6.4% respectively). These results suggest significantly better results in common PEx surgical repair techniques (i.e. Nuss and Ravitch) than uncommon techniques (i.e. Implants and Robicsek). The results suggest slightly better outcomes in pediatric Nuss procedure patients as compared with all other groups. We recommend that symptomatic pediatric patients with uncomplicated PEx receive the Nuss procedure. We suggest that adult patients receive the Nuss or Ravitch procedure, even though the long-term complication rates of the adult Nuss procedure require more investigation. PMID:24506826



Automatic modeling of pectus excavatum corrective prosthesis using artificial neural networks.  


Pectus excavatum is the most common deformity of the thorax. Pre-operative diagnosis usually includes Computed Tomography (CT) to successfully employ a thoracic prosthesis for anterior chest wall remodeling. Aiming at the elimination of radiation exposure, this paper presents a novel methodology for the replacement of CT by a 3D laser scanner (radiation-free) for prosthesis modeling. The complete elimination of CT is based on an accurate determination of ribs position and prosthesis placement region through skin surface points. The developed solution resorts to a normalized and combined outcome of an artificial neural network (ANN) set. Each ANN model was trained with data vectors from 165 male patients and using soft tissue thicknesses (STT) comprising information from the skin and rib cage (automatically determined by image processing algorithms). Tests revealed that ribs position for prosthesis placement and modeling can be estimated with an average error of 5.0 ± 3.6mm. One also showed that the ANN performance can be improved by introducing a manually determined initial STT value in the ANN normalization procedure (average error of 2.82 ± 0.76 mm). Such error range is well below current prosthesis manual modeling (approximately 11 mm), which can provide a valuable and radiation-free procedure for prosthesis personalization. PMID:25070021

Rodrigues, Pedro L; Rodrigues, Nuno F; Pinho, A C M; Fonseca, Jaime C; Correia-Pinto, Jorge; Vilaça, João L



Patient Satisfaction Following Minimally Invasive Repair of Pectus Excavatum: Single Surgeon Experience  

PubMed Central

Background: Pectus excavatum (PE) is the most common chest wall deformity in adolescent life. Nuss procedure is a well-established technique for the repair of PE. The indication for correction is mainly medical aesthetic. Advantages of Nuss over conventional methods include reduced length of hospital stay, smaller incisions, and absence of need for osteochondrectomies. Here, we describe our experience with this procedure. Materials and Methods: This was a retrospective study of patients who underwent Nuss procedure by a single surgeon between 2006 and 2010 in a regional center. Indications for surgery included the following: Progressive deformity and psychological stress. All patients underwent chest X-ray and pulmonary function testing. A standard Nuss procedure was performed using a single bar. Patients’ satisfaction was assessed by a questionnaire and follow-up clinic letters. Satisfaction with body image was scored on a scale of 1-10. Results: Eleven patients with PE underwent correction by Nuss procedure. Mean age of the patient was 19 years (range: 15-30). The average hospital stay was 7 days (range: 4-23 days). There was no mortality and no episodes of wound infection. In the immediate post-operative period, three patients (12.5%) were noted to have poor pain control. The post-operative course was uneventful in all cases except one patient who developed lung collapse, pleural effusion, and bar dislocation. Hundred percent of patients were satisfied with the scar. Seven patients scored 7 out of 10 on satisfaction with body image and two patients scored 6 or less. None of the patients complained of chronic pain. Conclusion: Nuss procedure is an effective method for the correction of PE. Most patients were satisfied with the outcome and none experienced chronic pain. PMID:23741581

Barua, Anupama; Rao, Vinay P.; Barua, Biplab; Majewski, Andrzej



Pectus excavatum repair  


... after surgery. Then the surgeon uses a special instrument to rotate the bar and lift the sternum ... IV) or through a catheter placed in the spine (an epidural). After that, pain is usually managed ...


Pectus carinatum.  


Pectus carinatum or keel chest is a spectrum of progressive inborn anomalies of the anterior chest wall, named after the keel (carina) of ancient Roman ships. It defines a wide spectrum of inborn protrusion anomalies of the sternum and/or the adjacent costal cartilages. Pectus carinatum is often associated with various conditions, notably Marfan disease, homocystinuria, prune belly, Morquio syndrome, osteogenesis imperfecta, Noonan syndrome, and mitral valve prolapse. Treatment of pectus carinatum by nonsurgical methods such as exercise and casting has not been worthwhile, whereas surgical management is simple and successful. PMID:20974441

Robicsek, Francis; Watts, Larry T



Overcorrection during treatment of pectus deformities with DCC orthoses: experience in 17 cases  

PubMed Central

Treatment of pectus carinatum and pectus excavatum with dynamic chest compressor (DCC) orthoses have been reported by Haje and others. The goal of this study was to demonstrate that overcorrection during orthotic treatment of children and adolescents with pectus deformities can occur and requires medical attention. Of 3,028 children and adolescents with pectus deformities, observed between 1977 and October 2005, 1,824 were prescribed treatment with DCC orthoses and, after a few months of treatment, some overcorrection was noted in 30 patients. Of the patients who received orthoses, 738 had a minimum follow-up of 1 year and 17 of these, 2 with pectus excavatum and 15 with pectus carinatum, presented overcorrection and were studied. The dynamic remodeling method (DCC orthoses + exercises) was applied. The procedures, adopted according to each patient’s needs, were: decreasing the time of orthosis wear and/or the tightening of the screws, introducing a second orthosis, and improving the prescribed exercises and/or encouraging the patient to perform them more intensively. The therapy was successful in all patients, and the result was maintained in one case of pectus excavatum followed up until adulthood. It was concluded that overcorrection during DCC orthosis wear can occur and that careful medical follow-up is necessary if this complication is to be successfully reversed. PMID:16474937

Haje, D. P.



[Use of Negative Pressure Wound Therapy on Surgical Incisions (Prevena™) after Surgery of Pectus Deformities Reduces Wound Complications.  


Introduction: Pectus surgery can lead to postoperative wound complications in some cases. The purpose of this study is to determine whether preventive negative pressure wound therapy (NPWT) could reduce wound complications after open pectus surgery. Material and Methods: 100 patients after open procedure for the treatment of pectus excavatum or pectus carinatum in the years 2010 to 2012 were retrospectively analysed. 50 patients treated with Prevena™ (KCI Medical Products GmbH, Wiesbaden, Germany) were compared with 50 patients whose wounds were covered with OPSITE® film (Smith & Nephew, Hamburg, Germany). Wound closure was performed following a standard procedure as well as the placement of subcutaneous drains. Therefore two comparable groups of patients were formed and analysed by standardised parameters. The wound dressing was placed epicutaneously immediately after wound closure in the operating room and removed after 5 days in each case. Follow-ups were performed immediately after removal of the wound dressing, at the time of discharge from hospital as well as 6 and 12 weeks after operation. The wounds were checked for tenderness, pain, secretion, redness and fistulas. Results: The Prevena group showed 10?% wound complications which needed operative treatment, whereas the OPSITE group showed complications in 24?%. Some patients who were treated with Prevena showed superficial skin lesions at the rim of the foam and the film. All of these lesions healed well. Conclusion: Treating wounds postoperatively with preventive measures (NPWT) showed a remarkable reduction of wound complications following open pectus surgery whereas statistically the difference was not significant (p?=?0.074). PMID:24647815

Simon, K; Schulz-Drost, M; Besendörfer, M; Carbon, R T; Schulz-Drost, S



Tecto-Cerebellar Dysraphia Manifesting as Occipital Meningocoele Associated with Congenital Melanocytic Nevi and Pectus Excavatum  

PubMed Central

Background Only few reported cases of tectocerebellar dysraphia with occipital encephalocele have been reported in the literature. Case Presentation Three month baby boy, the first child of healthy, consanguineous parents presented with a small swelling over the occipital region since birth. The child also used to have apneic spells without cyanosis and spontaneous recovery. CT scan showed absence of the cerebellar vermis, absence of tectum and the 4th ventricle communicating with the occipital menigocoele sac and an occipital bone defect. The excision of the encephalocoele sac was performed, however the child continued to have apneic spells and did not do well. Conclusion In our child irregular respiration probably was the manifestation of the tecto-cerebellar dysraphia syndrome complex and associated shunt malfunction followed by seizures decompensated the physiology of the child leading to fatal outcome. PMID:23056693

Agrawal, Amit; Joharapurkar, Sudhakar Ratanlal; Khan, Ata-Ullah



Briacavatolides D-F, new briaranes from the Taiwanese octocoral Briareum excavatum.  


In the continued search for novel bioactive substances from the Taiwanese octocoral Briareum excavatum collected at Orchid Island, three new briarane-type diterpenoids, briacavatolides D-F (1-3) were isolated from the acetone extract. The structures of these compounds were elucidated by extensive NMR spectroscopic analysis and physical data. The anti-HCMV (human cytomegalovirus) activity of 1-3 and their cytotoxicity against selected cancer cell lines were evaluated. PMID:23118724

Wang, Shang-Kwei; Yeh, Tsun-Tai; Duh, Chang-Yih



Cáncer infantil: Tratamiento

Cáncer infantil: Tratamiento Tumores cerebrales infantiles Descripción del tratamiento de tumores de cerebro y de médula espinal infantiles (PDQ®) [ pacientes ] [ profesionales ] Resumen de información revisada por expertos acerca del tratamiento de tumores


Toxin accumulation and feeding behaviour of the planktonic copepod Calanus finmarchicus exposed to the red-tide dinoflagellate Alexandrium excavatum  

Microsoft Academic Search

The planktonic copepod Calanus finmarchicus is a dominant member of the zooplankton community in the lower St. Lawrence Estuary in eastern Canada. Blooms of the toxic marine dinoflagellate Alexandrium excavatum which produces high cellular levels of paralytic shellfish poisoning (PSP) toxins, occur during the period of high C. finmarchicus production in summer in this region. To study the feeding behaviour

N. Turriff; J. A. Runge; A. D. Cerebella



Finite element analysis of pectus carinatum surgical correction via a minimally invasive approach.  


Pectus carinatum (PC) is a chest deformity caused by a disproportionate growth of the costal cartilages compared to the bony thoracic skeleton, pulling the sternum towards, which leads to its protrusion. There has been a growing interest on using the 'reversed Nuss' technique as a minimally invasive procedure for PC surgical correction. A corrective bar is introduced between the skin and the thoracic cage and positioned on top of the sternum highest protrusion area for continuous pressure. Then, it is fixed to the ribs and kept implanted for about 2-3 years. The purpose of this work was to (a) assess the stresses distribution on the thoracic cage that arise from the procedure, and (b) investigate the impact of different positioning of the corrective bar along the sternum. The higher stresses were generated on the 4th, 5th and 6th ribs backend, supporting the hypothesis of pectus deformities correction-induced scoliosis. The different bar positioning originated different stresses on the ribs' backend. The bar position that led to lower stresses generated on the ribs backend was the one that also led to the smallest sternum displacement. However, this may be preferred, as the risk of induced scoliosis is lowered. PMID:24428546

Neves, Sara C; Pinho, Acm; Fonseca, Jaime C; Rodrigues, Nuno F; Henriques-Coelho, Tiago; Correia-Pinto, Jorge; Vilaça, João L



Safe performance of spinal anesthesia in a critical patient with neurofibromatosis, pectus carinatum, and temporomandibular joint dysfunction: A case report  

PubMed Central

Background Neurofibromatosis is a syndrome caused by the abnormal deposition of neural tissues of the nervous system, endocrine system, visceral structures, and skin. On the other hand, pectus carinatum and temporomandibular joint dysfunction are illnesses that adversly affect the respiratory system and cause additional problems in airway management. Case Presentation Fifty-eight-year-old Turkish male patient had neurofibromatosis, pectus carinatum and temporomandibular joint dysfunction. The case was due to be operated on with the diagnosis of incarcerated umbilical hernia. Spinal anesthesia was successfully performed and the duration of the surgery was 1 hour. No postoperative complications were observed and he was discharged from the hospital on the 3rd post-operative day. Conclusion The anesthetic management of patients with neurofibromatosis requires attention to all possible abnormalities and associated disturbances. Furthermore, the presence of pectus carinatum and temporomandibular joint dysfunction also increase the potential risks. The operation was successfully completed with spinal anesthesia that was carefully applied upon taking the required measures and considering all pathologies that may accompany the case and complications that may occur. PMID:20438631



Tratamiento del cáncer

Información sobre métodos diversos de tratar el cáncer. Cómo encontrar a un doctor o un establecimiento de tratamiento para personas con cáncer, y recursos económicos para ellas. Se incluyen también descripciones y explicaciones de tratamientos convencionales para los tipos específicos de cáncer, y un resumen de la medicina complementaria y alternativa.


Plummer-Vinson syndrome with pectus carinatum mitral valve prolapsus and exotropia in an 18-year-old boy.  


The Plummer-Vinson syndrome is a clinical syndrome characterised by dysphagia, web or webs in upper oesophagus and iron-deficiency anaemia. The syndrome is often seen in women of age 40-70 years and rarely in adolescents. Plummer-Vinson syndrome might be associated with malignancy, myeloproliferative disorder and autoimmune diseases including coeliac disease, rheumatoid arthritis and Sjögren syndrome. However, according to our literature search, there are no reports of such case associated with thorax deformity, cardiac pathology and ocular findings. We present a case of an 18-year-old boy with a rare presentation of this syndrome including pectus carinatum, exotropia and mitral valve prolapsus. PMID:24451233

Sahin, Cem; Ozseker, Burak; Rencuzogullari, Ibrahim; Zeybek, Arife



In vitro acaricidal effect of plant extract of neem seed oil ( Azadirachta indica) on egg, immature, and adult stages of Hyalomma anatolicum excavatum (Ixodoidea: Ixodidae)  

Microsoft Academic Search

Effects of the plant extract of neem seed (Azadirachta indica) on eggs, immature, and adult stages of Hyalomma anatolicum excavatum was studied at concentrations of 1.6, 3.2, 6.4, and 12.8%. The extract was found to have a significant effect on the hatching rate of eggs. It significantly increased the hatching rate during the first 7 days post-treatment (DPT) giving incompletely

S. Abdel-Shafy; A. A. Zayed



Tratamiento actual del estreñimiento infantil  

Microsoft Academic Search

ResumenEl estreñimiento infantil es un problema mundial. Es una de las molestias más comunes que tienen que afrontar tanto los pediatras generales como los gastroenterólogos pediátricos. El tratamiento del estreñimiento crónico es problemático, a menudo exige un seguimiento a largo plazo y el uso de medicamentos. A pesar de su elevada frecuencia, se han realizado pocos ensayos aleatorizados para investigar

Olivia Liem; Carlo Di Lorenzo; Jan A. J. M Taminiau; Hayat M. Mousa; Marc A. Benninga



Tratamiento del paludismo pediátrico: Papel de las intervenciones nutricionales  

Microsoft Academic Search

ResumenEl paludismo es una causa primordial de morbilidad y mortalidad en niños, particularmente en África subsahariana. Aunque se ha logrado un progreso considerable en el tratamiento del paludismo pediátrico con el tratamiento de combinación basado en la artemisinina, siguen existiendo numerosos obstáculos que se oponen a la puesta en práctica efectiva de estas nuevas opciones terapéuticas sumamente eficaces. Análogamente, si

Akoto Kwame Osei; Davidson H. Hamer



El uso de la neuromodulación para el tratamiento del temblor  

PubMed Central

Introducción: El temblor puede ser un desorden incapacitante y el tratamiento de primera línea para estos pacientes es farmacológico. Sin embargo, este tratamiento puede llevar a una reducción satisfactoria del temblor en sólo el 50% de los pacientes con temblor esencial. La talamotomía era el tratamiento de elección para el temblor refractario al tratamiento médico hasta que comenzó a utilizarse la estimulación cerebral profunda (ECP) del núcleo ventral intermedio (Vim) del tálamo. En la actualidad, raramente se realiza la talamotomía. Métodos: Este artículo es una revisión no sistemática de las indicaciones, resultados, parámetros de programación y técnica quirúrgica de la ECP del Vim para el tratamiento del temblor. Resultados: Aunque los resultados clínicos son similares usando la talamotomía o la ECP del Vim, la primera causa más efectos adversos que la última. Además, la ECP puede ser usada bilateralmente, mientras que la talamotomía tiene un alto riesgo de causar disartria cuando se realiza de ambos lados. La ECP del Vim logró una adecuada mejoría del temblor en varias series de pacientes con temblor causado por temblor esencial, enfermedad de Parkinson o esclerosis múltiple. Además del Vim, hay otros blancos que están siendo usados por varios autores, tales como la zona incerta y las radiaciones prelemniscales. Conclusión: La ECP del Vim es un tratamiento útil para el temblor incapacitante refractario al tratamiento médico. Es esencial realizar una precisa selección de pacientes, así como utilizar una técnica quirúrgica correcta. Aún se desconoce el mejor blanco estereotáctico para el temblor, aunque el Vim es el más usado. PMID:25165613

Bendersky, Damián; Ajler, Pablo; Yampolsky, Claudio



Cánceres poco comunes en la niñez: Tratamiento (PDQ®)

Resumen de información revisada por expertos acerca del tratamiento de los cánceres poco comunes en la niñez como los cánceres de la cabeza y el cuello, el tórax, el abdomen, el aparato reproductor, la piel y otros.


Management of Congenital Chest Wall Deformities  

PubMed Central

Congenital chest wall deformities are considered to be anomalies in chest wall growth. These can be categorized as either rib cage overgrowth or deformities related to inadequate growth (aplasia or dysplasia). Rib cage overgrowth leads to depression of the sternum (pectus excavatum) or protuberance of the sternum (pectus carinatum) and accounts for greater than 90% of congenital chest wall deformities. The remaining deformities are a result of inadequate growth. Evolution in the management of congenital chest wall deformities has made significant progress over the past 25 years. This article will review chest wall deformities and the current management strategies of these interesting anomalies. PMID:22294949

Blanco, Felix C.; Elliott, Steven T.; Sandler, Anthony D.




Microsoft Academic Search

El estudio del tratamiento térmico de recocido de homogenización es fundamental para lograr las condiciones microestructurales adecuadas que permitan obtener propiedades mecánicas excelentes al procesar plásticamente una determinada aleación. Este tratamiento térmico, que se aplica después de la colada y antes de someter a las aleaciones a tratamientos termomecánicos o de deformación para obtener productos intermedios o finales, es muy

F. Fraudita; J. Gómez; E. Puchi


Increased incidence of thoracic wall deformities in related Bengal kittens.  


Clinical records made during routine vaccinations were compared between populations of domestic shorthair cats and Bengal kittens. An increased incidence (12/244) of thoracic wall deformity was detected amongst the Bengal kittens. Deformities detected were: pectus excavatum (five), unilateral thoracic wall concavity (six) and scoliosis (one). Five-generation pedigrees were analysed for the affected kittens that showed a high degree of common ancestry indicating the likelihood of a familial cause. PMID:22311892

Charlesworth, Timothy M; Sturgess, Christopher P



Nueva opción de tratamiento para mujeres jóvenes con cáncer de seno sensible a las hormonas

Un fármaco usado para el tratamiento del cáncer de seno (mama), conocido como exemestano, es más eficaz que tamoxifeno, un fármaco preventivo de uso común para el cáncer de seno, en la prevención de la recidiva del cáncer de seno en mujeres jóvenes que también reciben tratamiento posoperativo para suprimir el funcionamiento ovárico. Los resultados de este estudio se presentaron en mujeres que tenían un tipo de cáncer de seno en estadio inicial sensible al tratamiento hormonal.


Estudio de Asignación de Opciones Individualizadas de Tratamiento (TAILORx): preguntas y respuestas

Hoy se inició el Estudio de Asignación de Opciones Individualizadas de Tratamiento (Trial Assigning IndividuaLized Options for Treatment (Rx), o TAILORx, el cual evaluará si los genes que están frecuentemente asociados con el riesgo de recurrencia entre las mujeres con cáncer de seno en etapa inicial pueden ser utilizados para asignar a las pacientes el tratamiento más adecuado y efectivo.



Microsoft Academic Search

Esta investigación tuvo como objetivo proponer alternativas de reutilización del agua regenerada por los Sistemas de Tratamiento de Aguas Residuales Domesticas existentes en la Península de Paraguana. La investigación inicio con la identificación de los Sistemas de Tratamiento de Aguas Residuales Domesticas existentes en la Península de Paraguana, se realizaron visitas para describir la situación actual de los Sistemas. Además,

Maria Beatriz Bracho; Zuleima Escalona; Roberto Garcia



Alternativas de reutilización de aguas residuales regeneradas en sistemas de tratamiento de la península de Paraguaná  

Microsoft Academic Search

Esta investigación tuvo como objetivo proponer alternativas de reutilización del agua regenerada por los Sistemas de Tratamiento de Aguas Residuales Domesticas existentes en la Península de Paraguana. La investigación inicio con la identificación de los Sistemas de Tratamiento de Aguas Residuales Domesticas existentes en la Península de Paraguana, se realizaron visitas para describir la situación actual de los Sistemas. Además,

Maria Beatriz Bracho; Zuleima Escalona; Roberto Garcia



InternatIonal ProsPectus 2014  

E-print Network

achieve your ambitions. I look forward to welcoming you to Charles Darwin University. Professor Barney Glover Vice-Chancellor, Charles Darwin University Welcome from the Vice-chancellor Welcome to charles Darwin university Charles Darwin University (CDU) offers exciting academic opportunities and globally


Lanzamiento del estudio de tratamiento personalizado para el cáncer de seno

Hoy se inició el Estudio de Asignación de Opciones Individualizadas de Tratamiento (Trial Assigning IndividuaLized Options for Treatment (Rx), o TAILORx, el cual evaluará si los genes que están frecuentemente asociados con el riesgo de recurrencia entre las mujeres con cáncer de seno en etapa inicial pueden ser utilizados para asignar a las pacientes el tratamiento más adecuado y efectivo. Preguntas y respuestas


Foraminotomia cervical posterior en el tratamiento de conflictos foraminales  

PubMed Central

Introducción: La foraminomotima cervical posterior es un procedimiento utilizado para la descompresion radicular por via posterior y constituye una alternativa a la via clásica anterior. En este trabajo evaluamos nuestra serie de pacientes tratados por esta via. Método: Desde enero de 2008 a diciembre de 2011, 17 pacientes (18 foraminotomías) fueron operados por presentar cervicobraquialgia a causa de un conflicto foraminal, realizando un foraminotomía cervical posterior. Los pacientes fueron evaluados en el postoperatorio inmediato, al mes y a los 3 meses de la cirugía. Los parámetros para valorar los resultados fueron la Escala Análoga del Dolor (VAS), la Neck Disability Index y los criterios de Odom. Resultados: El dolor radicular por conflicto foraminal secundario a hernia de disco cervical fue el síntoma y la patología predominante. El nivel más afectado fue C5-C6. La resolución completa del dolor radicular se observó en casi todos los pacientes. La VAS preoperatoria en promedio fue de 8.8 (mínimo 8 – máximo 10), con una franca mejoría en todos los casos (0.4 en el último control). La media en la Neck Disability Index al inicio fue de 35.3 (mínimo 32 – máximo 45), con una evolución favorable en la evaluación final (0.6). Los Criterios de Odom para la evaluación de pacientes operados de columna cervical fueron satisfactorios con un promedio de 1.17. Se observaron complicaciones en 4 pacientes (23%), todas tuvieron una evolución favorable. No hubo infecciones, discitis ni empeoramiento de los síntomas preexistentes en ningún paciente. Conclusión: La foraminotomía cervical posterior es un procedimiento efectivo para el tratamiento del dolor radicular en los conflictos foraminales PMID:23596556

Campero, Álvaro; Barrera, Ramiro; Ajler, Pablo



Isolated asymptomatic short sternum in a healthy young girl.  


Congenital sternal defects are rare deformities frequently associated with other anomalies of the chest wall and other organ systems. Although pectus excavatum, pectus carinatum, and cleft sternum can present as isolated deformity, in most cases they are associated with heart and inner organs anomalies and described as symptoms of syndromes like Marfan syndrome, Noonan syndrome, Poland anomaly, and Cantrell pentalogy. In contrast, the etiology of an isolated defect is not well understood. We observed a short sternum (dysmorphic manubrium, hypoplastic body, and complete absence of the xiphoid process) in a completely asymptomatic 13-year-old woman. A comprehensive instrumental exams panel was performed to exclude associated anomalies of the heart and of the other organ systems. The patient was completely asymptomatic and she did not need any medical or surgical treatment. To our knowledge, this is the first case of isolated short sternum reported in literature. PMID:25143854

Turturro, Francesco; Calderaro, Cosma; Montanaro, Antonello; Labianca, Luca; Argento, Giuseppe; Ferretti, Andrea



Isolated Asymptomatic Short Sternum in a Healthy Young Girl  

PubMed Central

Congenital sternal defects are rare deformities frequently associated with other anomalies of the chest wall and other organ systems. Although pectus excavatum, pectus carinatum, and cleft sternum can present as isolated deformity, in most cases they are associated with heart and inner organs anomalies and described as symptoms of syndromes like Marfan syndrome, Noonan syndrome, Poland anomaly, and Cantrell pentalogy. In contrast, the etiology of an isolated defect is not well understood. We observed a short sternum (dysmorphic manubrium, hypoplastic body, and complete absence of the xiphoid process) in a completely asymptomatic 13-year-old woman. A comprehensive instrumental exams panel was performed to exclude associated anomalies of the heart and of the other organ systems. The patient was completely asymptomatic and she did not need any medical or surgical treatment. To our knowledge, this is the first case of isolated short sternum reported in literature. PMID:25143854

Turturro, Francesco; Calderaro, Cosma; Montanaro, Antonello; Labianca, Luca; Argento, Giuseppe; Ferretti, Andrea



Sndrome de Waterhouse-Friderichsen: Ms eficacia en el tratamiento con el uso precoz de Protena-C ?  

E-print Network

Síndrome de Waterhouse-Friderichsen: Más eficacia en el tratamiento con el uso precoz de Proteína uniformizados = ... Introducción: Necesidad de mejora del tratamiento del Síndrome de Waterhouse­ Friderichsen

Manstein, Dietmar J.


Some clinical and cytogenetic observations on a ring chromosome 13 (p11 q34).  


A girl of 9-10/12 years of age with 46,XX,r(13)(p11q34) karyotypes was studied. She presented some clinical and radiological features, such as pectus excavatum, scalp alopecic area, 12th rib agenesis, hypoplastic pelvis, small gluteal pits and hypoplasia of the external genitalia in a female, which have never been previously described in other cases with ring 13 chromosomes. Cytogenetically, in vivo and in vitro viability of complete monosomic and partially trisomic and tetrasomic cells was found. The presence of nucleolus organizer regions and association of the ring 13 with other acrocentrics question the exclusivity of these attributes to acrocentrics p12. PMID:317785

Hernandez, A; Garcia-Cruz, D; Plascencia, L; Nazara, Z; Rivera, H; Sanchez-Corona, J; Cantu, J M



El tratamiento con cloro es un mtodo para desinfectar un pozo de agua. Se recomien-  

E-print Network

exceso de lluvia entran en el pozo. Si el agua subterránea constituye en sí la fuente de bacterias, elEl tratamiento con cloro es un método para desinfectar un pozo de agua. Se recomien- da cuando un sistema de agua está contam- inado con bacterias. La contaminación puede ocurrir en la instalación del


Se inicia estudio de los NIH sobre respuestas excepcionales al tratamiento del cáncer

La Iniciativa de Respuestas Excepcionales (Exceptional Responders Initiative), un estudio que investiga los factores moleculares de los tumores en pacientes de cáncer que responden en forma excepcional al tratamiento con medicamentos, se inició hoy bajo la guía del Instituto Nacional del Cáncer (NCI). Los científicos tratarán de identificar en los tumores las características moleculares que predicen si un medicamento o una clase de medicamento en particular será beneficioso o no.


Prevalence of Swimming Puppy Syndrome in 2,443 Puppies during the Years 2006–2012 in Thailand  

PubMed Central

The purpose of this study was to report on the prevalence of swimming puppy syndrome (SPS) and investigate predisposing factors. Data were recorded from 2,443 puppies (1,183 males and 1,260 females) in Thailand, October 2006–September 2012, including breed, sex, number of puppies per litter, type of nest floor, number of affected limbs, and occurrence of pectus excavatum. Fifty-two puppies (2.13%) were diagnosed with SPS. The breed most frequently affected was English Bulldog (8.33%). There was no significant difference (P > 0.05) between presence and absence of disease based on sex, breed, and nest floor type. The number of puppies per litter was associated with SPS; puppies from smaller litters (1.92?±?1.12) had a higher prevalence of the disease (P < 0.01) than puppies from larger litters (3.64?±?2.24). Moreover, 15.38% of puppies with affected limbs showed signs of pectus excavatum (8/52); this clinical sign was more prevalent (P < 0.01) in puppies with all four limbs affected with SPS. PMID:23819102

Yano, Terdsak



Tratamiento ayuda a las mujeres jóvenes a preservar la fertilidad durante la quimioterapia para el cáncer de seno

Las mujeres jóvenes con cáncer de seno (mama) lograron preservar la fertilidad durante los tratamientos del cáncer con un fármaco inyectable bloqueador de hormonas que les provocó menopausia temporal. Los resultados del estudio se anunciaron hoy en el congreso anual de la Sociedad Americana de Oncología Clínica (ASCO), y provienen del Estudio de Prevención de la Menopausia Temprana (POEMS), patrocinado por el Instituto Nacional del Cáncer (NCI).


Extensión del Formalismo de Orbitales de Defecto Cuántico al tratamiento del efecto Stark (SQDO).  

NASA Astrophysics Data System (ADS)

El estudio experimental de las interacciones de átomos Rydberg altamente excitados con campos eléctricos ha experimentado un creciente interés durante las dos últimas décadas debido, en gran medida, al desarrollo de nuevas técnicas para crear y estudiar átomos Rydberg en el laboratorio. Acompañando a estas nuevas técnicas experimentales, es necesario el desarrollo de modelos teóricos que nos permitan contrastar sus medidas y conocer mejor los fundamentos de los mismos. Desde el punto de vista teórico el conocimiento del desdoblamiento de los niveles energéticos de un átomo en función de la magnitud del campo eléctrico aplicado (lo que se conoce como mapa Stark) es el mejor punto de partida para la descripción del sistema y un prerrequisito fundamental para el cálculo de distintas propiedades atómicas en presencia del campo eléctrico tales como intensidades de transición, umbrales de ionización de campo eléctrico, tiempos de vida, posición y anchura de cruces evitados, etc. En este trabajo presentamos la adaptación del método de orbitales de defecto cuántico [1,2,3] al tratamiento del efecto Stark (SQDO) [4] y su aplicación al cálculo de los desdoblamientos energéticos y fuerzas de oscilador de estados Rydberg en los átomos de Li, Na y K. El propósito de este estudio es, por un lado, desarrollar métodos fiables para la determinación de propiedades atómicas en presencia de campos eléctricos y, por otro, mostrar la fiabilidad de las funciones de onda QDO en la descripción del efecto Stark en sistemas atómicos.

Menéndez, J. M.; Martín, I.; Velasco, A. M.


Lipid storage myopathy with clinical markers of Marfan syndrome: A rare association  

PubMed Central

Disorders of lipid metabolism can cause variable clinical presentations, often involving skeletal muscle, alone or together with other tissues. A 19-year-old boy presented with a 2-year history of muscle pain, cramps, exercise intolerance and progressive weakness of proximal lower limbs. Examination revealed skeletal markers of Marfan syndrome in the form of increased arm span compared with height, Kyphoscoliois, moderate pectus excavatum, high arched palate and wrist sign. He also had mild neck flexor weakness and proximal lower limb weakness with areflexia. Pathologic findings revealed lipid-laden fine vacuoles in the muscle fibers. Possibility of carnitine deficiency myopathy was considered and the patient was started on carnitine and Co Q. The patient made remarkable clinical improvement over the next 2 months. This case is reported for rarity of the association of clinical markers of Marfan syndrome and lipid storage myopathy and sparse literature on lipid storage myopathy in the Indian context. PMID:23349609

Ramakrishnan, Subasree; Narayanappa, Gayathri; Christopher, Rita



A simplified method to pass the bar through the mediastinum in the nuss technique.  


In the minimally invasive repair of pectus excavatum, as reported by Nuss, the introducer is inserted into the thoracic cavity, making its way through the mediastinum, and emerges through a left intercostal space. Then, 2 umbilical tapes are tied to the introducer tip as a guide to pass into this tunnel the curved bar with the concave side up. When fat tissue is present in the anterior mediastinum or bars with notched ends are used, passage of the umbilical tape could be challenging and eventually lead to bleeding. In this report, we describe a different and simple technique to allow this passage, from left to right, in a very safe and effective way. PMID:25639424

Messineo, Antonio; Ghionzoli, Marco; Lo Piccolo, Roberto; Milanez De Campos, José Ribas



A de novo 3.57 Mb microdeletion in 8q12.3q13.2 in a patient with mild intellectual disability and epilepsy.  


A female patient, nine years of age, is reported with a history characterized by delay of psychomotor and speech development, mild to moderate intellectual disability and persistent sleep disturbances since the age of two. The patient showed facial dysmorphisms, a pectus excavatum and a sandal gap. Apart from lowered intelligence, neuropsychological functioning disclosed impaired attentional capacities and executive control as well as weak motor skills. Genome wide SNP array analysis revealed a 3.57 Mb de novo microdeletion in band q12.3 of chromosome 8. The long lasting sleep disorders turned out to originate from a rare juvenile epilepsy, continuous spike-waves during slow sleep (CSWS) syndrome, that includes the electrical status epilepticus in sleep (ESES) phenomenon. MRI-scanning of the brain showed no abnormalities. To the authors knowledge, this is the first report of a de novo 8q12.3q13.2 microdeletion syndrome that presents with ESES/CSWS. PMID:22138216

Verhoeven, Willem M A; Egger, Jos I M; Feenstra, Ilse; de Leeuw, Nicole



Congenital dyserythropoietic anemia type I presenting as persistent pulmonary hypertension with pigeon chest deformity.  


Congenital dyserythropoietic anemia (CDA) type-1 is a rare genetic disorder of ineffective erythropoiesis, which manifests in macrocytic anemia. We report a CDA1 patient who as a newborn presented with macrocytic anemia and persistent pulmonary hypertension of the newborn (PPHN) requiring mechanical ventilation. Post-infancy, the patient developed acral dysmorphism and pectus excavatum the latter rarely found in CDA1. Patient is a compound heterozygote for a known maternal-derived missense-mutation (c.1796A?>?G/p.Asn589Ser) and a novel paternal-derived deletion-mutation (c.1104_1106del/Phe365del) in CDAN1. This report highlights the importance of recognizing PPHN as a presenting symptom of CDA1 and expands the repertoire of the accompanying mutations and axial skeletal malformations. PMID:24420417

El-Sheikh, Ayman A; Hashem, Hasan; Holman, Carol; Vyas, Yatin M



Modification of the Nuss Procedure: The Single-incision Technique  

PubMed Central

Summary: The Nuss procedure is a prevalent minimally invasive surgery for pectus excavatum. Although the Nuss procedure has the advantage of leaving less obtrusive scars, the standard technique requires at least 3 skin incisions to insert several instruments. We experienced 7 cases of the modified Nuss procedure using a single incision during a 7-year period. To facilitate passing of the bar, a traction guide was created according to our unique method. There was no need for a bar stabilizer, and no severe intraoperative complications occurred. All patients exhibited satisfactory short-term results; however, 1 patient suffered from bar rotation and required repeat surgery for fixation. Two patients underwent bar removal via the same single incision without any difficulties. PMID:25506539

Togashi, Shinji; Domoto, Takashi; Sasaki, Kaoru; Kiyosawa, Tomoharu; Sekido, Mitsuru



Ellis van Creveld syndome.  


Ellis-van Creveld syndrome (EVC) or chondroectodermal dysplasia is a rare autosomal recessive disorder. It is a tetrad of chondrodysplasia, ectodermal dysplasia, polydactyly, and congenital heart disease. In several case reports, dysplasia involving other organs has also been identified. The exact prevalence is unknown, but the syndrome seems more common among the Amish community. Many Indian cases have also been reported. This report describes a classical case of EVC syndrome in a 22 year old woman of Indian origin born of a consanginous marriage. The patient had chondrodysplasia of tubular bones resulting in disproportionate dwarfism, postaxial polydactyly, severely dystrophic nails, partially absent teeth, pectus excavatum with narrow chest, knock knees and AV canal defect. PMID:20329417

Ghanekar, Jaishree; Sangrampurkar, Sujata; Hulinaykar, Raman; Ahmer, Tariq



Pulmonary Nontuberculous Mycobacterial Disease  

PubMed Central

Rationale: Pulmonary nontuberculous mycobacterial (PNTM) disease is increasing, but predisposing features have been elusive. Objectives: To prospectively determine the morphotype, immunophenotype, and cystic fibrosis transmembrane conductance regulator genotype in a large cohort with PNTM. Methods: We prospectively enrolled 63 patients with PNTM infection, each of whom had computerized tomography, echocardiogram, pulmonary function, and flow cytometry of peripheral blood. In vitro cytokine production in response to mitogen, LPS, and cytokines was performed. Anthropometric measurements were compared with National Health and Nutrition Examination Survey (NHANES) age- and ethnicity-matched female control subjects extracted from the NHANES 2001–2002 dataset. Measurements and Main Results: Patients were 59.9 (±9.8 yr [SD]) old, and 5.4 (±7.9 yr) from diagnosis to enrollment. Patients were 95% female, 91% white, and 68% lifetime nonsmokers. A total of 46 were infected with Mycobacterium avium complex, M. xenopi, or M. kansasii; 17 were infected with rapidly growing mycobacteria. Female patients were significantly taller (164.7 vs. 161.0 cm; P < 0.001) and thinner (body mass index, 21.1 vs. 28.2; P < 0.001) than matched NHANES control subjects, and thinner (body mass index, 21.1 vs. 26.8; P = 0.002) than patients with disseminated nontuberculous mycobacterial infection. A total of 51% of patients had scoliosis, 11% pectus excavatum, and 9% mitral valve prolapse, all significantly more than reference populations. Stimulated cytokine production was similar to that of healthy control subjects, including the IFN-?/IL-12 pathway. CD4+, CD8+, B, and natural killer cell numbers were normal. A total of 36% of patients had mutations in the cystic fibrosis transmembrane conductance regulator gene. Conclusions: Patients with PNTM infection are taller and leaner than control subjects, with high rates of scoliosis, pectus excavatum, mitral valve prolapse, and cystic fibrosis transmembrane conductance regulator mutations, but without recognized immune defects. PMID:18703788

Kim, Richard D.; Greenberg, David E.; Ehrmantraut, Mary E.; Guide, Shireen V.; Ding, Li; Shea, Yvonne; Brown, Margaret R.; Chernick, Milica; Steagall, Wendy K.; Glasgow, Connie G.; Lin, JingPing; Jolley, Clara; Sorbara, Lynn; Raffeld, Mark; Hill, Suvimol; Avila, Nilo; Sachdev, Vandana; Barnhart, Lisa A.; Anderson, Victoria L.; Claypool, Reginald; Hilligoss, Dianne M.; Garofalo, Mary; Fitzgerald, Alan; Anaya-O'Brien, Sandra; Darnell, Dirk; DeCastro, Rosamma; Menning, Heather M.; Ricklefs, Stacy M.; Porcella, Stephen F.; Olivier, Kenneth N.; Moss, Joel; Holland, Steven M.



A comprehensive newborn exam: part II. Skin, trunk, extremities, neurologic.  


Skin findings are common during the newborn examination. Although these findings are often benign, it is important to visualize the entire skin surface to distinguish these findings and appropriately reassure parents. The chest should be observed for symmetric movement, pectus excavatum, pectus carinatum, prominent xiphoid, or breast tissue. The infant should be as relaxed as possible so that the physician can more easily detect any abdominal masses, which are often renal in origin. A single umbilical artery may be associated with another congenital abnormality, especially renal anomalies, and intrauterine growth restriction and prematurity. Signs of ambiguous genitalia include clitoromegaly and fused labia in girls, and bilateral undescended testes, a micropenis, or a bifid scrotum in boys. Sacral dimples do not warrant further evaluation if they are less than 0.5 cm in diameter, are located within 2.5 cm of the anal verge, and are not associated with cutaneous markers; dimples that do not fit these criteria require ultrasonography to evaluate for spinal dysraphism. Brachial plexus injuries are most common in newborns who are large for gestational age, and physical therapy may be required to achieve normal function. Patients with abnormal findings on Ortolani and Barlow maneuvers should be evaluated further for hip dysplasia. It is also important to assess newborns for tone and confirm the presence of normal primitive reflexes. PMID:25251089

Lewis, Mary L



Briacavatolides A-C, new briaranes from the Taiwanese octocoral Briareum excavatum.  


In order to search for novel bioactive substances from marine organisms, we have investigated the organic extracts of the Taiwanese octocoral Briareumexcavatum collected at Orchid Island. Three new briarane-type diterpenoids, briacavatolides A-C (1-3) as well as two known briaranes, briaexcavatolide U (4) and briaexcavatin L (5) were isolated from the acetone extract. The structures of these compounds were elucidated by extensive NMR spectroscopic analysis and physical data. The anti-HCMV (human cytomegalovirus) activity of 1-5 and their cytotoxicity against selected cancer cell lines were evaluated. PMID:22822353

Yeh, Tsun-Tai; Wang, Shang-Kwei; Dai, Chang-Feng; Duh, Chang-Yih



Mediastinal Lymph Nodes and Pulmonary Nodules in Children: MDCT Findings in a Cohort of Healthy Subjects.  


OBJECTIVE. Existing data are very limited on incidentally detected pulmonary nodules or mediastinal lymph nodes in healthy children who undergo chest MDCT. We aimed to evaluate the prevalence, distribution, and average dimensions of these occasional findings in a cohort of otherwise healthy patients. MATERIALS AND METHODS. Two radiologists reviewed in consensus the scans of patients referred for chest MDCT during the preoperative workup for pectus carinatum or pectus excavatum treatments. Exclusion criteria included the presence of any documented malignancy (by date of MDCT or during the 2 years after the examination), history of recent infections, or trauma. Patients' records were assessed after 2 years for the development of any malignancy. RESULTS. A total of 99 individuals (63 boys, 36 girls; mean age, 13.5 years; range, 4-18 years) who fulfilled the study criteria were evaluated. The presence of at least one pulmonary nodule was observed in 75% of the patients, with a mean diameter of 2.8 mm. Of a total number of 225 pulmonary nodules, only 24 (10.7%) were calcified. Mediastinal lymph nodes were also identified in 81% of the cases, with a maximum diameter of 7 mm (smallest axis). CONCLUSION. The presence of pulmonary nodules or mediastinal lymph nodes on the basis of preoperative chest MDCT scans in healthy children is frequent. Given that 95% of the nodules and 100% of the lymph nodes measured less than 6 mm and 7 mm, respectively, we conclude that incidental findings under these limits are very unlikely to be pathologic. PMID:25539235

Alves, Giordano Rafael Tronco; Marchiori, Edson; Irion, Klaus Loureiro; Guimarães, Marcos Duarte; da Cunha, Carol Fernandes Jerzewski Sotero; de Souza, Vinícius Valério Silveira; Hochhegger, Bruno



Childhood hypophosphatasia due to a de novo missense mutation in the tissue-nonspecific alkaline phosphatase gene.  


Hypophosphatasia is an inherited disorder due to mutations in the bone alkaline phosphatase (ALPL) gene. We report here a patient with childhood hypophosphatasia diagnosed at 1.4 yr because of pectus excavatum, large anterior fontanel, rachitic skeletal changes, and low serum alkaline phosphatase. Sequencing of the ALPL gene produced evidence of two distinct missense mutations, E174K (c.571G>A), of maternal origin, and a de novo mutation, M45I (c.186G>C). The study of various microsatellite polymorphisms ruled out false paternity and therefore confirmed that M45I occurred de novo in the paternal germline or in the early development of the patient. Site-directed mutagenesis showed that M45I results in the absence of in vitro alkaline phosphatase activity, suggesting that the mutation is a severe allele. In conclusion, childhood hypophosphatasia in this patient is the result of compound heterozygosity for the moderate mutation E174K and a novel severe de novo mutation M45I. PMID:15671102

Taillandier, A; Sallinen, S-L; Brun-Heath, I; De Mazancourt, P; Serre, J-L; Mornet, E



4q12-4q21.21 deletion genotype-phenotype correlation and the absence of piebaldism in presence of KIT haploinsufficiency.  


Chromosome 4q deletion syndrome is a rare intellectual disability disorder caused by a variety of non-recurrent deletions of 4q. We describe the evolution of the phenotypic features of a female patient with a previously unreported deletion of 4q12-4q21.21 (hg 18; 54,711,575-79,601,919). By review reported individuals with interstitial deletions extending telomeric from 4q12 have syndromic intellectual disability with variable piebaldism. We expand the phenotype to include dolichocephaly, pectus excavatum, hip dysplasia, pes planus, myopia, lens opacities, and an absence of spoken language but not of communication through sign. The proposita also did not have piebaldism suggesting again that piebaldism arises from a mechanism more complex than simple haploinsufficiency of KIT. Comparing deletions among affected individuals localizes the critical interval within 4q12-4q13.1, although the absence of molecular boundaries for nearly all reported cases precludes precise delineation and genotype-phenotype correlation. © 2014 Wiley Periodicals, Inc. PMID:25355368

Hemati, Parisa; du Souich, Christèle; Boerkoel, Cornelius F



Interstitial Deletions at 6q14.1q15 Associated with Developmental Delay and a Marfanoid Phenotype  

PubMed Central

There are a number of reports of interstitial deletions of the long arm of chromosome 6 that have developmental delay and obesity suggesting that this is a distinct phenotype almost like Prader-Willi syndrome. Here we report a patient with a similar deletion but a strikingly different phenotype, one more in keeping with Marfan syndrome, although he does not fulfil the criteria for that syndrome. Array comparative genomic hybridization was performed to investigate a patient with a striking phenotype. This revealed an interstitial deletion of 6q14.1q15. Parental FISH studies were normal, indicating that this is a de novo deletion. Our patient has a completely different phenotype compared to other patients reported to have similar deletions. The common feature is developmental delay, but the body features are quite different in that our patient is tall, strikingly thin with pectus excavatum, scoliosis, skin striae, arachnodactyly, pes planus, cataracts, and a high-arched palate. This contrasts with other patients who have a similar deletion but have short stature and obesity. 6q14.1q15 interstitial deletions can have a very variable phenotype and do not necessarily conform to a clinical recognizable microdeletion syndrome caused by haploinsufficiency of dosage-sensitive genes in that region as proposed by others. PMID:24167463

Lowry, R.B.; Chernos, J.E.; Connelly, M.S.; Wyse, J.P.H.



Moyamoya disease associated with asymptomatic mosaic Turner syndrome: a rare cause of hemorrhagic stroke.  


Moyamoya disease is a rare cerebrovascular anomaly involving the intracranial carotid arteries that can present clinically with either ischemic or hemorrhagic disease. Moyamoya syndrome, indistinguishable from moyamoya disease at presentation, is associated with multiple clinical conditions including neurofibromatosis type 1, autoimmune disease, prior radiation therapy, Down syndrome, and Turner syndrome. We present the first reported case of an adult patient with previously unrecognized mosaic Turner syndrome with acute subarachnoid and intracerebral hemorrhage as the initial manifestation of moyamoya syndrome. A 52-year-old woman was admitted with a subarachnoid hemorrhage with associated flame-shaped intracerebral hemorrhage in the left frontal lobe. Physical examination revealed short stature, pectus excavatum, small fingers, micrognathia, and mild facial dysmorphism. Cerebral angiography showed features consistent with bilateral moyamoya disease, aberrant intrathoracic vessels, and an unruptured 4-mm right superior hypophyseal aneurysm. Genetic analysis confirmed a diagnosis of mosaic Turner syndrome. Our case report is the first documented presentation of adult moyamoya syndrome with subarachnoid and intracerebral hemorrhage as the initial presentation of mosaic Turner syndrome. It illustrates the utility of genetic evaluation in patients with cerebrovascular disease and dysmorphism. PMID:24103673

Manjila, Sunil; Miller, Benjamin R; Rao-Frisch, Anitha; Otvos, Balint; Mitchell, Anna; Bambakidis, Nicholas C; De Georgia, Michael A



Patterns of pulmonary perfusion scans in normal subjects  

SciTech Connect

A vital factor conditioning the usage of the pulmonary perfusion (Q) scan in the evaluation of patients suspected of pulmonary embolism is the prevalence of abnormal Q scans in subjects free of cardiopulmonary disease. Because this prevalence has not been well defined, we performed Q scans in 80 nonsmoking subjects 18 to 29 yr of age having no known active cardiopulmonary disease. Each subject underwent a history, physical examination, electrocardiogram, spirometry, and PA chest roentgenogram, followed by a 6-view Q scan. Two subjects in whom a Q defect was suspected underwent a /sup 133/Xe equilibrium-washout ventilation (V) scan. All Q scans were interpreted blindly and independently by 2 experienced readers. Seventy-nine of the 80 Q scans were read as normal. No subject demonstrated a lobar or segmental defect. One of the 80 subjects, who had a mild pectus excavatum, had a left upper lobe subsegmental defect, which was not seen on the V scan. Based on the statistical analysis of these data, no more than 3.68% of normal nonsmoking persons in this age group may have a lobar or segmental Q scan defect and no more than 6.77% may have a subsegmental defect (with 95% confidence). Therefore, our study indicated that Q scan defects, particularly lobar or segmental, are rarely present among normal nonsmokers in this age group.

Wallace, J.M.; Moser, K.M.; Hartman, M.T.; Ashburn, W.L.



Clinical report: Two patients with atelosteogenesis type I caused by missense mutations affecting the same FLNB residue.  


We present two patients with Atelosteogenesis Type I (AO type I) caused by two novel Filamin B (FLNB) mutations affecting the same FLNB residue: c.542G > A, predicting p.Gly181Asp and c.542G > C, predicting p.Gly181Arg. Both children had typical manifestations of AO type I, with severe rhizomelic shortening of the extremities, limited elbow and knee extension with mild webbing, pectus excavatum, broad thumbs with brachydactyly that was most marked for digits 3-5, dislocated hips and bilateral talipes equinovarus. Facial features included proptosis, hypertelorism, downslanting palpebral fissures, cleft palate, and retromicrognathia. The clinical course of one child was influenced by airway instability and bronchopulmonary dysplasia that complicated intubation and prevented separation from ventilator support. Respiratory insufficiency with tracheal hypoplasia, laryngeal stenosis, and pulmonary hypoplasia have all been described in patients with AO type I and we conclude that compromised pulmonary function is a major contributor to morbidity and mortality in this condition. PMID:23401428

Li, Ben C; Hogue, Jacob; Eilers, Meg; Mehrotra, Pavni; Hyland, James; Holm, Tara; Prosen, Tracy; Slavotinek, Anne M



[Prune-Belly Syndrome: a case report].  


Prune-Belly Syndrome (PBS) is a rare congenital syndrome characterized by the absence of abdominal muscles, anomalies in the urinary tract, megaureter, cryptorchidism or testicular agenesis, hypertension and worsening chronic kidney disease (CKD). The incidence is estimated between 1 out of 35,000 and 1 out of 50,000 born alive, and it affects males in prevalence (97%). In the present study we describe the case of a 38 year old male patient (followed since May 2011) affected by PBS, CKD, one functional kidney at the scintigraphy, pediatric testicular implants, bladder surgery and correction of pectus excavatum. At the beginning of the observation, renal function was deteriorated, with a creatinine 3.3 mg/dl, GFR calculated at MDRD 23 ml/min, proteinuria in nephrotic range (4 g/day), high blood pressure, anemia and hyperparathyroidism. In the following examinations renal function framework worsened, despite the adoption of a low-protein diet. Due to the functional trend, the patient was prescribed hemodialysis as substitute treatment. In January 2013 a first attempt of artero-venous fistula (AVF) did not succeed, while a new AVF in March 2013 resulted effective. In July hemodialysis was started. In the future, we expect to insert the patient in the Kidney Transplant List (since surgical feasibility has already been positively evaluated). Our case is quite peculiar due to the late beginning of substitute treatment. Further, SPB represents a challenge that, in the absence of a prompt and effective treatment, inevitably it leads to terminal uremia; nevertheless, given a proper treatment, a transplant with good chances of success can be envisaged. PMID:25030009

Tattoli, Fabio; De Prisco, Ornella; Gherzi, Maurizio; Falconi, Daniela; Marazzi, Federico; Marengo, Marita; Serra, Ilaria; Tamagnone, Michela; Formica, Marco



Hemofilia: diagnóstico molecular y alternativas de tratamiento  

Microsoft Academic Search

SUMMARY The haemophilia is a recessive disease tied to the X chromosome that generally men suffer. The genetic preimplantation diagnosis (GPD), the prenatal diagnosis and the molecular diagnosis of the mutations that cause haemophilia, are realized in isolated investigations (researches) in order to do primary prevention, provide advise to the carriers of the disease and their families, which has allowed




[Conservative treatment of deformities of the anterior chest wall].  


The authors have treated 55 deformities of the anterior chest wall in children. There were 37 cases of symmetrical pectus carinatum, 15 cases of asymmetrical pectus carinatum and 3 cases of pectus arcuatum. Associated lesions of the ribs, scapulae and spine are described. Treatment in every case was by plaster casts followed by a plaster jacket and exercises. The results were much more satisfactory in deformities associated with prominence than with depression of the sternum. In pectus carinatum, the results were better when the apex of the deformity was more distal. The best age for treatment was between 12 and 13 years. No patient was treated by operation. PMID:144304

Vidal, J; Perdriolle, R; Brahin, B; Connes, H; Fischbach, C



Chromosome 10q tetrasomy: First reported case  

SciTech Connect

While there are several reports of trisomy 10q (at least 35), we are not aware of previous cases of 10q tetrasomy. We present what we believe to be the initial report of such a case. R.J. is a 6 1/2 year old white male who presented with multiple dysmorphic features, marked articulation problems, hyperactivity, and developmental delays. He is the product of a term uncomplicated pregnancy. There was a normal spontaneous vaginal delivery with a birth weight of 6 lbs. 4oz. and length was 19 1/2 inch. Dysmorphic features include small size, an asymmetrically small head, low set ears with overfolded helixes, bilateral ptosis, downslanting eyes, right eye esotropia, prominent nose, asymmetric facies, high palate, mild pectus excavatum deformity of chest, and hyperextensible elbow joints. The patient is in special needs classes for mildly mentally handicapped students. Chromosome analysis at a resolution of 800 bands revealed a complex rearrangement of chromosomes 10 and 11. The segment 10q25.3 to q16.3 appears to be inverted and duplicated within the long arm of chromosome 10 at band q25.3 and the same segment of chromosome 10 is present on the terminal end of the short arm of chromosome 11. There is no visible loss of material from chromosome 11. Fluorescence in situ hybridization was performed with a chromosome 10 specific {open_quotes}paint{close_quotes} to confirm that all of the material on the abnormal 10 and the material on the terminal short arm of 11 was from chromosome 10. Thus, it appears that the segment 10q25.3 to q26.3 is present in four copies. Parental chromosome studies are normal. We compared findings which differ in that the case of 10q tetrasomy did not have prenatal growth deficiency, microphthalmia, cleft palate, digital anomalies, heart, or renal defects. Whereas most cases of 10q trisomy are said to have severe mental deficiency, our case of 10q tetrasomy was only mildly delayed. We report this first apparent cited case of 10q tetrasomy.

Blackston, R.D.; May, K.M.; Jones, F.D. [Emory Univ., Atlanta, GA (United States)] [and others



Fenómenos de somatización en la población penitenciaria: diagnóstico y tratamiento  

Microsoft Academic Search

Daily physiological processes, excess physical fatigue, subclinical viral infections and certain environmental situations can all cause some kind of physical pain or malaise in 75% of adults in a typical week. When the individual refuses to accept medical opinion and attributes the pain to a physical illness and persistently seeks diagnosis and treatment, then there is a possibility of an

J. García Campayo



La espiritualidad en el tratamiento del cáncer (PDQ®)

Resumen de información revisada por expertos acerca de la influencia que tiene la espiritualidad y la religión en las personas que tienen cáncer. Se discuten varios métodos sobre manejo e intervención.


Actualización: Tratamiento de la alopecia androgenética Treatment of androgenetic alopecia  

Microsoft Academic Search

Alopecia is a frequent health concern that affects both men and women. A succestul treatment has been searched for many years. This article deals with causes that can be detected through questioning and physical examination in order to treat patients with androgenetic alopecia in the best possible way: topic minoxidil and oral finasteride.

Jorge Kontos


Vitíligo. Tratamiento de 12 casos con tacrolimus tópico  

Microsoft Academic Search

IntroductionVitiligo is a frequent dyschromia, characterized by achromic macules that reflect the absence of melanocytes. The cause of this selective destruction seems to be due to an autoimmune phenomenon. Tacrolimus is an immunomodulator produced by Streptomyces tsukubaensis, whose topical use has been approved for atopic dermatitis. It has been tested in other dermatoses where immunological phenomena are involved.

Pablo Almeida; Leopoldo Borrego; Julio Rodríguez-López; Dunia Luján; Daniel Cameselle; Buenaventura Hernández



rea de Biomecnica del Deporte Rendimiento Deportivo 209 DESARROLLO DE UNA "TOOLBOX" DE TRATAMIENTO  

E-print Network

Área de Biomecánica del Deporte ­ Rendimiento Deportivo 209 DESARROLLO DE UNA "TOOLBOX" DE_mail: Pantrigo, J.J. Vara Gazapo, A. Galapero, L. Facultad de Ciencias del Deporte. Universidad DE CIENCIAS DEL DEPORTE "corrompe" la señal obtenida. Así que, el procesamiento digital de señales se

Pantrigo Fernández, Juan José



Microsoft Academic Search

Main filamentous microorganisms have been identified in effluents of sewage from three food industries, which lay on Toluca-Lerma industry zone. This sewage is sent to an industrial company to be treated, its activated sludge process has been affected by filamentous microor- ganisms identified at the entrance and flow circulation during treatment. In effluents of sewage, the main filamentous microorganisms are:



Diagnóstico y tratamiento de la osteoporosis en mayores de 75 años  

Microsoft Academic Search

Osteoporosis is a progressive skeletal disease characterized by a decrease in bone strength and an increase in the number of fractures. This disease is considered by the World Health Organization to be the second most important health problem in the world after cardiovascular disease. The prevalence of osteoporosis is increasing due to population aging.With age, the loss of bone mass

María Jesús Moro-Álvarez; Manuel Díaz-Curiel



Hacia una adaptación cultural para el tratamiento de trastornos alimentarios en latinos en Estados Unidos  

PubMed Central

Eating disorders affect all ethnic and socioeconomic groups. However, evidence based treatments for eating disorders have been developed and tested exclusively on Caucasian populations. With the purpose to develop a culturally sensitive framework for the eating disorders treatment in Latinos/as, the objectives of this work were: 1) identify and describe some of the relevant cultural elements for eating disorders in the Latino population and, 2) to draft a culturally sensitive intervention model for eating disorders in Latino population in the United States. Providing culturally sensitive treatments for Latinos with psychiatric disorders is essential to reverse public health disparities. PMID:22003472

Reyes-Rodríguez, Mae Lynn; Bulik, Cynthia M.



Apoyo familiar en el apego al tratamiento de la hipertensión arterial esencial  

Microsoft Academic Search

Objective. To assess the relationship between family sup- port and drug therapy compliance in essential hyperten- sion. Material and methods. A case-control study was conducted between May and December 1999, at Mexican Institute of Social Security Regional Hospital in Durango, among 80 hypertensive subjects; 40 were cases and 40 con- trols. Cases were subjects who complied with drug therapy and

Florentina Marín-Reyes; Martha Rodríguez-Morán



Apego al tratamiento farmacológico en pacientes con diagnóstico de diabetes mellitus tipo 2  

Microsoft Academic Search

Objective. To establish the frequency of compliance to pharmacological therapy, and to identify non-compliance factors, in relation to metabolic control on patients with type-II diabetes mellitus. Material and methods. A com- parative cross-sectional study was conducted between 1997 and 1998, among 150 type-II diabetic patients, at the Family Medicine Unit No. 33, of the Mexican Institute of Social Security, in

Blanca Rosa Durán-Varela; Blanca Rivera-Chavira; Ernesto Franco-Gallegos




Microsoft Academic Search

In this work we have studied the degradation of Antioxidant Activities by thermic treat- ment at 70, 80 y 90ºC in juices of varios citrus: orange (Citrus sinensis), mandarins (Citrus reticu- lata), lemon (Citrus limon), pomelo (Citrus paradisi) y lime Rangpur (Citrus limonia Osbeck). Antioxidant Activities were measured using the DPPH method. Antioxidant Activities degradation follows a zero-order reaction.



Tratamiento de mostos utilizando el filtro anaerobio (treatment of must using an anaerobic filter). Master thesis  

SciTech Connect

This study reports on the feasibility of treating the slops from rum distilleries with an anaerobic filter composed of an oxygen free reactor filled with a plastic filtering media, commercially known as 'Actifil' with a diameter of 5/8 inches (16mm). This filter is similar in appearance to an aerobic biofilter (trickling filter). The main difference between the two systems is that on the anaerobic filter the flow is upward so that the filter medium is always completely submerged.

Negron, R.M.



The Association Between Connective Tissue Laxity and the Risk of an Abdominal Aortic Aneurysm  

Microsoft Academic Search

Aims: to investigate whether connective tissue laxity is associated with abdominal aortic aneurysms (AAA). Methods: a nested case control study in a population-based screening programme. The presence of pes planus, scoliosis, pectus deformities, flexible auricular cartilages and Gorling's sign were combined with the Beighton joint mobility score to form a connective tissue laxity score. The association between connective tissue laxity

ABM Wilmink; CRG Quick; C Sff Hubbard; NE Day



Klinefelter's syndrome presenting with leg ulcers.  


A 54-year-old man of Persian origin presented to our department with a 1-year history of ulcers on the right leg that had been unresponsive to numerous topical treatments, accompanied by lymphedema of the right leg. Medical history included hypergonadotropic hypogonadism, which had not been further investigated. He was treated for 20 years with testosterone IM once monthly, which he stopped a year before the current hospitalization for unclear reasons. The patient reported no congenital lymphedema. Physical examination revealed two deep skin ulcers (Figure 1) on the right leg measuring 10 cm in diameter with raised irregular inflammatory borders and a boggy, necrotic base discharging a purulent hemorrhagic exudate. Bilateral leg pitting edema and right lymphangitis with lymphadenitis were noted. He had low head hair implantment, sparse hair on the body and head, hyperpigmentation on both legs, onychodystrophia of the toenails (mainly the large toe and less prominent on the other toes), which was atrophic lichen-planus-like in appearance and needed no trimming (Figure 2), normal hand nails, oral thrush, and angular cheilitis. Other physical findings were gynecomastia, pectus excavatum, small and firm testicles, long extremities, asymmetrical goiter, systolic murmur 2/6 in left sternal border, and slow and inappropriate behavior. The patient's temperature on admission was 39 degrees C. Blood cultures were negative for bacterial growth. Results of laboratory investigations included hemoglobin (11.2 g/dL), hematocrit (26.8%), normal mean corpuscular volume and mean corpuscular hemoglobin volume, and red blood cell distribution width (16%). Blood smear showed spherocytes, slight hypochromia, anisocytosis, macrocytosis, and microcytosis. Blood chemistry values were taken for iron (4 micro g/dL [normal range 40-150 micro g/dL]), transferrin (193 mg/dL [normal range 220-400 mg/dL]), ferritin (1128 ng/mL [normal range 14-160 ng/mL]), transferrin saturation (1.5% [normal range 20%-55%]), serum folate (within normal limits), and vitamin B12 (within normal limits). Direct Coombs' test equaled positive 2 + IgG. All these values indicated anemia of chronic diseases combined with hemolytic anemia. Further blood work-up tested antinuclear antibody (positive <1:80 homogeneous pattern), rheumatoid factors (143 IU/mL [positive >8.5 IU/mL]), C-reactive protein (286 mg/L [normal range 0-5 mg/L]), anticardiolipin IgM antibody (9.0 monophosphoryl lipid U/mL [normal range 0-7.00 MPL U/mL]) and antithrombin III activity (135% [normal range 74%-114%]). Results of other blood tests were within normal limits or negative, including lupus anticoagulant, beta2 glycoprotein, anticardiolipin IgG Ab, anti-ss DNA Ab, C3, C4, anti-RO, anti-LA, anti-SC-70, anti-SM Ab, P-ANCA, C-ANCA, TSH, FT4, anti-T microsomal, antithyroglobulin, protein C activity, protein S free, cryoglobulins, serum immunoelectrophoresis, VDRL, hepatitis C antibodies, hepatitis B antigen, and human immunodeficiency virus. Endocrinological work-up examined luteinizing hormone (22.9 mIU/mL [normal range for adult men 0.8-6 mIU/mL]), follicle stimulating hormone (49.7 mIU/mL [normal range for adult men 1-11 mIU/mL]), testosterone (0.24 ng/mL [normal range for adult men 2.5-8.0 ng/mL]), bioavailable testosterone (0.02 ng/mL [normal range for adult men >0.6 ng/mL]), and percent bioavailable test (8.1% [normal value >20%]). These results indicate hypergonadotropic hypogonadism. Plasminogen activator inhibitor 1 was 6 U (normal value 5-20 U/mL). Karyotyping performed by G-banding technique revealed a 47 XXY karyotype, which is diagnostic of Klinefelter's syndrome. Doppler ultrasound of the leg ulcers disclosed partial thrombus in the distal right femoral vein. X-rays and bone scan displayed osteomyelitis along the right tibia. Histological examination of a 4-mm punch biopsy from the ulcer border revealed hyperkeratosis, acanthosis, hypergranulosis, and mixed inflammatory infiltrate containing eosinophils compatible with chronic ulcer. Multiple vessels were seen, compatible with a h

De Morentin, Helena Martinez; Dodiuk-Gad, Roni P; Brenner, Sarah



New evidence on a cold case: trophic transmission, distribution and host-specificity in Hedruris spinigera (Nematoda: Hedruridae).  


The life cycle of Hedruris spinigera Baylis, 1931 (Nematoda: Hedruridae) is determined here with the first formal identification of the parasite's intermediate host: the crustacean amphipod Paracorophium excavatum Thomson. Adult H. spinigera are redescribed from specimens collected from the stomach of fishes, Retropinna retropinna (Richardson) and Aldrichettaforsteri (Valenciennes), from Lake Waihola, New Zealand. Immature adults of the parasite collected from intermediate hosts (P. excavatum) are also described for the first time. The prevalence, abundance and intensity of infection of H. spinigera in several fish species are quantified along with the occurrence of P. excavatum, the parasite's intermediate host, in fish stomach contents. Although H. spinigera's transmission mode (trophic transmission) and fish diet potentially expose all fish species to infection, some level of host specificity must exist as parasite prevalence, abundance and intensity of infection vary greatly between potential definitive host species. We suggest here that the anatomy of the fish digestive tract and especially that of the stomach plays an important role in host suitability for H. spinigera. While P. excavatum is the only intermediate host in Lake Waihola, H. spinigera was found in six different fish species: Aldrichetta forsteri, Galaxias maculatus (Jenyns), Retropinna retropinna, Rhombosolea retiaria Hutton, Perca fluviatilis Linnaeus and Salmo trutta Linnaeus; although typical hedrurid attachment and mating positions were observed only in R. retropinna and A. forsteri. The limited distribution of H. spinigera is most likely due to that of its different host species (intermediate and definitive), all inhabitants of coastal fresh and brackish waters. PMID:20941914

Luque, José L; Vieira, Fabiano M; Herrmann, Kristin; King, Tania M; Poulin, Robert; Lagrue, Clément



Taponamiento y limpieza de membranas inmersas en un bioreactor anaerobio para el tratamiento de aguas residuales industriales  

Microsoft Academic Search

The anaerobic membrane bioreactor (MBR) performance was evaluated in the first stage of a two stages investigation. A bioreactor was built in the laboratory. Different parameters such as: Volatile Acid, Alkalinity, pH, COD, flux and transmembrane pressure were measured. Besides, the performance of a poly- propylene membrane was evaluated, too. In the second stage a non-conventional membrane were built in

A. González


Coste-efectividad de la combinación dutasterida y tamsulosina en el tratamiento de la hiperplasia benigna de próstata en España  

Microsoft Academic Search

Objectivesto evaluate the incremental cost-effectiveness ratio (ICER) of the combination therapy with dutasteride and tamsulosin (DUT+TAM) as initiation treatment versus the most used drug in Spain, tamsulosin (TAM), in the treatment of moderate to severe benign prostatic hyperplasia (BPH) with risk of progression.

F. Antoñanzas; F. Brenes; J. M. Molero; A. Fernández-Pro; A. Huerta; R. Palencia; J. M. Cozar



Curación asistida por presión negativa comparada con curación convencional en el tratamiento del pie diabético amputado. Ensayo clínico aleatorio  

Microsoft Academic Search

IntroductionFoot amputation wounds in patients with diabetes are complex and treatment is often difficult. At the moment negative pressure wound therapy (NPWT) is widely used for the treatment of several types of wounds. Nevertheless, the clinical evidence to support the application of this dressing in foot amputation wounds in patients with diabetes is scarce. The aim of this study was

Gustavo Sepúlveda; Manuel Espíndola; Mauricio Maureira; Edgardo Sepúlveda; José Ignacio Fernández; Claudia Oliva; Antonio Sanhueza; Manuel Vial; Carlos Manterola



Eficacia de Tacrolimus tópico en el tratamiento del vitíligo Effectiveness of topical tacrolimus in the treatment of vitiligo  

Microsoft Academic Search

Summary Vitiligo is an acquired, idiopathic disorder characterized by depigmented macules which involves an obvious cosmetic, social and psicological repercussion. Current treatment modalities for the management of vitiligo are multiple but, unfortunatelly, most of cases achieve inconsistent and incomplete responses. Recently, new pharmacolgical agents have been investigated like Tacrolimus. They are more selective, powerful, and with no local adverse side

Iolanda Prats Caelles


Evolución de las Teorías Cognoscitivas y del Tratamiento Cognoscitivo Conductual de la Anorexia Nerviosa The Evolution of Cognitive Theories and Behavioral Therapy for Anorexia Nervosa  

Microsoft Academic Search

Anorexia nervosa is the eating disorder (ED) that represents the highest mortality rate among psychiatric disorders, though the interest of investigators has been particularly centered on bulimia nervosa; probably because its incidence is higher, but also because the complexity of the clinical course of anorexia nervosa supposes a frustrating scenario that is constant for the therapist and the patient. The

Ximena Palacios Espinosa


Un estudio de los Institutos Nacionales de la Salud indica que dos dosis de vacuna contra los VPH pueden proteger tanto como el tratamiento completo

Dos dosis de Cervarix, la vacuna contra virus del papiloma humano (VPH), fueron tan efectivas como la pauta normal actual de tres dosis después de cuatro años de seguimiento. El estudio de vacuna en Costa Rica, patrocinado por el NCI, fue diseñado para evaluar la eficacia de Cervarix en una población determinada.


Informe Anual a la Nación sobre el Estado del Cáncer 1975-2002 con una sección especial sobre las tendencias de tratamiento: preguntas y respuestas

Las organizaciones oncológicas principales de la nación informan que el riesgo de los estadounidenses de morir de cáncer sigue disminuyendo y que las tasas de casos nuevos de cáncer permanecen estables. El Informe Anual a la Nación sobre el Estado del Cáncer, de 1975 a 2002, señala que las tasas de mortalidad de cáncer que se observaron para todos los cánceres combinados disminuyeron 1,1 por ciento por año de 1993 a 2002.


Déficits neurológicos y aracnoiditis secundarios a anestesia neuroaxial: rol de parestesias, punciones durales, anestésicos locales y género. Protocolo para su tratamiento  

Microsoft Academic Search

IntroductionAmong the complications of neuroaxial anesthesia, arachnoiditis and neurological deficit represent one of the most serious problems that anesthesiologists can face. Although the real frequency of this complication is unknown, the functional consequences for the patient and legal repercussions for the physician are devastating, mainly because most patients are not treated in a timely fashion, increasing the probability of a

A. Ramírez Bermejo; J. A. Aldrete; N. C. Godínez Cubillo; S. Bautista Sánchez; R. Ghaly; A. Kassian Rank



Eficacia del tratamiento antinflamatorio comparado con antibiótico y placebo en pacientes con bronquitis aguda no complicada y expectoración purulenta. Ensayo clínico aleatorio controlado con placebo.  

E-print Network

??Aquesta tesi tenia per objectiu conèixer l'eficàcia del tractament antiinflamatori (ibuprofèn 500 mg/8h/10d) o antibiòtic (amoxicil•lina+àcid clavulànic 500/125 mg/8h/10d) comparat amb placebo en la resolució… (more)

Bayona Faro, Carolina



Efectividad, seguridad y coste-efectividad de la terapia por presión negativa tópica para el tratamiento de las heridas crónicas: una revisión sistemática  

Microsoft Academic Search

Negative-pressure wound therapy (NPWT) is used to promote wound healing by using suction to drain excess fluid from wounds. A systematic literature review was undertaken to assess the effectiveness, safety and cost-effectiveness of NPWT for the treatment of chronic wounds. Medline, Embase, CENTRAL, CINAHL and the Cochrane Wounds Group Specialised Trials Register were searched. A total of 9 randomized controlled

María Trujillo-Martín; Lidia García-Pérez; Pedro Serrano-Aguilar



Sistema de aspiración-tracción en el tratamiento de la Fasciitis necrotizante del periné * Negative Pressure wound therapy for the treatment of perineal necrotizing fasciitis  

Microsoft Academic Search

Introduction: We discuss five patients treated at our institution. Besides the initial surgical debridement and antibiotic therapy, we used the negative-pressure wound therapy (NPWT) as part of their treatment. Patients and methods: The NPWT device was constructed with off-the-shelf components. After the diagnosis of perineal necrotizing fasciitis was established, all patients underwent surgical debridement of necrotic tissue. The wound was



Hutchinson-Gilford Progeria Syndrome: A Rare Genetic Disorder  

PubMed Central

Hutchinson-Gilford progeria syndrome (HGPS) is a rare pediatric genetic syndrome with incidence of one per eight million live births. The disorder is characterised by premature aging, generally leading to death at approximately 13.4 years of age. This is a follow-up study of a 9-year-old male with clinical and radiographic features highly suggestive of HGPS and presented here with description of differential diagnosis and dental consideration. This is the first case report of HGPS which showed pectus carinatum structure of chest. PMID:24288630

Panigrahi, Rajat G.; Panigrahi, Antarmayee; Vijayakumar, Poornima; Choudhury, Priyadarshini; Bhuyan, Sanat K.; Bhuyan, Ruchi; Maragathavalli, G.; Pati, Abhishek Ranjan



Silica-coated super paramagnetic iron oxide nanoparticles (SPION) as biocompatible contrast agent in biomedical photoacoustics  

PubMed Central

In this study, we report for the first time the use of silica-coated superparamagnetic iron oxide nanoparticles (SPION) as contrast agents in biomedical photoacoustic imaging. Using frequency-domain photoacoustic correlation (the photoacoustic radar), we investigated the effects of nanoparticle size, concentration and biological media (e.g. serum, sheep blood) on the photoacoustic response in turbid media. Maximum detection depth and the minimum measurable SPION concentration were determined experimentally. The nanoparticle-induced optical contrast ex vivo in dense muscular tissues (avian pectus and murine quadricept) was evaluated and the strong potential of silica-coated SPION as a possible photoacoustic contrast agents was demonstrated. PMID:23082291

Alwi, Rudolf; Telenkov, Sergey; Mandelis, Andreas; Leshuk, Timothy; Gu, Frank; Oladepo, Sulayman; Michaelian, Kirk




Microsoft Academic Search

Germinative and establishment of fresh Cecropia schreberiana, Trichospermum mexicanum and Hibiscus elatus seeds were tested under controlled stress conditions (heat, water, light and physical barrier) and exposed to pregerminative of hydration- dehydration and heat shock treatments. In the three species the biggest percentages of final germination under heat, water and illumination stress were obtained with the application of partial hydration

Jorge A. Sánchez; Bárbara Muñoz; Laura Montejo; Carretera de Varona



El Informe Anual a la Nación indica que las tasas de mortalidad por cáncer continúan declinando: los avances en el tratamiento del cáncer varían según el tipo de cáncer

Las organizaciones oncológicas principales de la nación informan que el riesgo de los estadounidenses de morir de cáncer sigue disminuyendo y que las tasas de casos nuevos de cáncer permanecen estables. El Informe Anual a la Nación sobre el Estado del Cáncer, de 1975 a 2002, señala que las tasas de mortalidad de cáncer que se observaron para todos los cánceres combinados disminuyeron 1,1 por ciento por año de 1993 a 2002.


Difusión de resultados iniciales del Estudio del Tamoxifeno y del Raloxifeno (STAR): el fármaco para el tratamiento de la osteoporosis, raloxifeno, es tan efectivo como el Tamoxifeno en la prevención de cáncer de seno invasor

Los resultados iniciales del Estudio del Tamoxifeno y del Raloxifeno, STAR, demuestran que el fármaco raloxifeno, actualmente utilizado para prevenir y tratar la osteoporosis en mujeres posmenopáusicas, funciona tan bien como el tamoxifeno para reducir el riesgo de cáncer de seno entre las mujeres posmenopáusicas que tienen riesgo elevado de padecer la enfermedad. Preguntas y respuestas


Treatment of non-small cell lung cancer with ifosfamide (IFO)+ 4'-epiadriamycin (EPI)+platinum vs. IFO+EPI: a GETLAC Study. Grupo de Estudio y Tratamiento Latinoamericano del Cáncer Study.  


203 patients with inoperable non-small cell lung cancer (NSCLC) were randomized to receive ifosfamide (IFO) 2.5 g/m2 days 1-2 + epirubicin (EPI) 70 mg/m2 day 1 with cisplatin (DDP) 70 mg/m2 day 1 (arm IEP), or without cisplatin (arm IE). For uroprophylaxis, mesna i.v. 20% of IFO dose, hour 0 and 3, and oral, 40% of IFO dose, hour 6 and 9, days 1-2 was given. Cycles were repeated every 28 days. Four cycles were required for evaluation purposes. After completion of chemotherapy, external beam irradiation 40 Gy was given over 4 weeks for stage III B responders. Most of the patients with stable disease, partial response or complete response (CR) received 6 cycles. The median follow-up of the trial is 30 months. There were no differences in overall response rates: arm IEP: 52% (2% CR); arm IE: 51% (13.5% CR). Median time to progression was 6 months (arm IEP) and 4 months (arm IE) (p = 0.4844). Toxicity ranged from mild to moderate. Nephrotoxicity was not seen; only 6 patients had neurotoxic side effects of short duration. Median survival according to treatment was 12 months for IEP arm (12% at 2 years) and 10 months for IE arm (21% at 2 years). IFO/mesna+EPI or IFO/mesna, EPI plus DDP appeared to be an active and well tolerated combination for the treatment of NSCLC, with a good survival time. PMID:7800338

Brocato, N; Bruno, M F; Araujo, C E; Cervellino, J C; Pirisi, C; Temperley, G; Sparrow, C; Savulsky, C; Balbiani, L R




Microsoft Academic Search

The proposed of fermentative treatment (biodeterioration) applied even six weeks at the bagasse maguey (Agave tequilana Weber), was object of promoting the fibrillation of the internal structure of the packaging fibrous (internal fibrillation), principally due to the activity of the microorganism created in a corn liquor substrate. Posteriori, whit the chemical treatment favored the softening and solubility of the lignin

T. Escoto-García; E. M. Vivanco-Castellanos; M. G. Lomelí-Ramírez; A. Arias-García


Testing road surface treatments to reduce erosion in forest roads in Honduras [Tratamientos de la superfi cie de rodadura para reducir la erosi??n en caminos forestales en Honduras  

USGS Publications Warehouse

Testing road surface treatments to reduce erosion in forest roads in Honduras. Cien. Inv. Agr. 36(3):425-432. Using forest roads produces more erosion and sedimentation than any other forest or agricultural activity. This study evaluated soil losses from a forest road in central Honduras over two consecutive years. We divided a 400-m segment of road into 8 experimental units, each 50 m in length. Four units were treated with Best Management Practices (BMPs) and four were left untreated. The BMP treatments included reshaping the road prism, installing culverts and reshaping of road ditches, compacting 20-cm layers of the road tread, crowning the road surface (3% slope, double drainage), longitudinal sloping (less than 12%), and adding a 10-cm layer of gravel (crush size = 0.63 cm). Soil movement was measured daily during the rainy seasons. The highest soil loss occurred in the control road, around 500 m3 km-1 per year, while the road treated with BMP lost approximately 225 m3km-1 per year. These results show that road surface erosion can be reduced up to 50% with the implementation of surface treatments.

Rivera, S.; Kershner, J.L.; Keller, G.R.



Chemotherapy with high dose ifosfamide/mesna plus cisplatin for the treatment of ovarian cancer: a study of the Grupo de Estudio y Tratamiento Latino-Americano del Cancer.  


Twenty-one evaluable patients with FIGO stages II-IV epithelial ovarian cancer, median age 57 (range 47-75 years), were treated with ifosfamide (IF), 3 g/m2 diluted in 500 ml saline solution, 8 hour intravenous (i.v.) infusion on days 1-5; mesna 20% of IF dose, i.v. bolus injection, was given at hours 0 and 4; mesna 40% of IF dose by oral route at hours 8 and 12, days 1-5; plus cisplatin 20 mg/m2 diluted in 500 ml saline solution, 2 hour i.v. infusion, days 1-5. Cycles were repeated every 4 weeks. All patients had metastatic lesions (mesentery, pleura, colon, cervix, abdominal wall, lung, liver, bladder, and nodes). Toxicity ranged from mild to moderate. All patients experienced alopecia, nausea, and vomiting. Neutropenia and anemia ranged from mild to moderate. One patient experienced mild brain confusion and two patients microscopic hematuria. Ten clinically complete responses (47%) and five clinically partial responses (23%) were registered, for an overall 70% objective response. However, after a second look performance in 10 patients with clinically complete response, six of 10 patients showed a pathological complete response and four showed pathological partial response. The median duration of complete response is about 33 months, and median partial response duration is 14 months. Although the numbers are small, these data indicate that combination chemotherapy with high dose ifosfamide/mesna plus cisplatin may be an active treatment for advanced ovarian carcinoma. PMID:1901372

Araujo, C E; Cervellino, J C; Pirisi, C; Pannunzio, O; Callegari, J



[Treatment of type 2 diabetes mellitus in patients with chronic kidney disease. Grupo de Trabajo para el Documento de Consenso sobre el tratamiento de la diabetes tipo 2 en el paciente con enfermedad renal crónica].  


Chronic kidney disease (CKD) and type 2 diabetes mellitus (T2DM) are highly prevalent chronic diseases, which represent an important public health problem and require a multidisciplinary management. T2DM is the main cause of CKD and it also causes a significant comorbidity with regard to non-diabetic nephropathy. Patients with diabetes and kidney disease represent a special risk group as they have higher morbi-mortality as well as higher risk of hypoglycemia than diabetic individuals with a normal kidney function. Treatment of T2DM in patients with CKD is controversial because of the scarcity of available evidence. The current consensus report aims to ease the appropriate selection and dosage of antidiabetic treatments as well as the establishment of safety objectives of glycemic control in patients with CKD. PMID:24268912

Gómez-Huelgas, Ricardo; Martínez-Castelao, Alberto; Artola, Sara; Górriz, José Luis; Menéndez, Edelmiro



Primary angioplasty vs. fibrinolysis in very old patients with acute myocardial infarction: TRIANA (TRatamiento del Infarto Agudo de miocardio eN Ancianos) randomized trial and pooled analysis with previous studies  

PubMed Central

Aims To compare primary percutaneous coronary intervention (pPCI) and fibrinolysis in very old patients with ST-segment elevation myocardial infarction (STEMI), in whom head-to-head comparisons between both strategies are scarce. Methods and results Patients ?75 years old with STEMI <6 h were randomized to pPCI or fibrinolysis. The primary endpoint was a composite of all-cause mortality, re-infarction, or disabling stroke at 30 days. The trial was prematurely stopped due to slow recruitment after enroling 266 patients (134 allocated to pPCI and 132 to fibrinolysis). Both groups were well balanced in baseline characteristics. Mean age was 81 years. The primary endpoint was reached in 25 patients in the pPCI group (18.9%) and 34 (25.4%) in the fibrinolysis arm [odds ratio (OR), 0.69; 95% confidence interval (CI) 0.38–1.23; P = 0.21]. Similarly, non-significant reductions were found in death (13.6 vs. 17.2%, P = 0.43), re-infarction (5.3 vs. 8.2%, P = 0.35), or disabling stroke (0.8 vs. 3.0%, P = 0.18). Recurrent ischaemia was less common in pPCI-treated patients (0.8 vs. 9.7%, P< 0.001). No differences were found in major bleeds. A pooled analysis with the two previous reperfusion trials performed in older patients showed an advantage of pPCI over fibrinolysis in reducing death, re-infarction, or stroke at 30 days (OR, 0.64; 95% CI 0.45–0.91). Conclusion Primary PCI seems to be the best reperfusion therapy for STEMI even for the oldest patients. Early contemporary fibrinolytic therapy may be a safe alternative to pPCI in the elderly when this is not available. # NCT00257309. PMID:20971744

Bueno, Héctor; Betriu, Amadeo; Heras, Magda; Alonso, Joaquín J.; Cequier, Angel; García, Eulogio J.; López-Sendón, José L.; Macaya, Carlos; Hernández-Antolín, Rosana; Bueno, Héctor; Hernández-Antolín, Rosana; Alonso, Joaquín J.; Betriu, Amadeo; Cequier, Angel; García, Eulogio J.; Heras, Magda; López-Sendón, José L.; Macaya, Carlos; Azpitarte, José; Sanz, Ginés; Chamorro, Angel; López-Palop, Ramón; Sionis, Alex; Arós, Fernando; García-Fernández, Eulogio; Rubio, Rafael; Hernández, Felipe; Tascón, Juan Carlos; Moreu, José; Betriu, Amadeu; Heras, Magda; Hernández-Antolín, Rosana; Fernández-Ortiz, Antonio; Morís, César; de Posada, Ignacio Sánchez; Cequier, Ángel; Esplugas, Enrique; Melgares, Rafael; Bosa, Francisco; García-González, Martín Jesús; Lezáun, Román; Carmona, José Ramón; Vázquez, José Manuel; Castro-Beiras, Alfonso; Picart, Joan García; de Rozas, José Domínguez; Fernández, José Díaz; Vázquez, Felipe Fernández; Alonso, Norberto; Zueco, José Javier; San José, José María; San Román, Alberto; Hernández, Carolina; García, José María Hernández; Alcántara, Ángel García; Bethencourt, Armando; Fiol, Miquel; Mancisidor, Xabier; Mancisidor, Xabier; Ruiz, Rafael; Hidalgo, Rafael; Sobrino, Nicolás; Maqueda, Isidoro González; Torres, Alfonso; Arós, Fernando; Amaro, Antonio; Jaquet, Michel



Prurito (PDQ®)

Resumen de información revisada por expertos acerca del prurito (picazón de la piel) como complicación a causa del cáncer y su tratamiento. Se discuten los enfoques del manejo y tratamiento del prurito.


Para mi el teatro es un ascesis, una cura de adelgazamiento': Entrevista a Mario Vargas Llosa  

E-print Network

usted al libre tratamiento que hacen los teatristas de las piezas dramáticas. ¿ Cuál es su postura como autor respecto al tratamiento del texto por parte del director, eso que una escritora argentina llamó canibalismo amoroso? Yo considero que el...

Espinosa Domí nguez, Carlos



On-Site Wastewater Treatment Systems: Spray Distribution System (Spanish)  

E-print Network

Dispositivo de desinfecci?n Tanque bomba Rociadores Dispositivo para tratamiento de aguas negras Sistemas individuales para el tratamiento de aguas negras Sistema de distribuci?n por aspersi?n con rociadores Bruce Lesikar y Juan Enciso Promotores...

Lesikar, Bruce J.; Enciso, Juan



Dolor (PDQ®)

Resumen de información revisada por expertos acerca del dolor como una complicación a causa del cáncer o su tratamiento. Se discuten enfoques sobre el manejo y tratamiento del dolor relacionado con el cáncer.


C A L I F O R N I A E N V I R O N M E N T A L P R O T E C T I O N A G E N C Y Boletn de Prensa  

E-print Network

industriales, así como la operación y el mantenimiento de una planta de tratamiento de aguas residuales y el, para 38 operadores, ingenieros y reguladores de plantas de tratamiento de aguas residuales de México plantas de tratamiento de aguas residuales. El curso incluyó temas tales como una revisión general de las


Platiquemos un rato...

1 La historia de Ana Y cómo ella recibió tratamiento para el cáncer 2 Ana tiene cáncer. 3 “Existen muchos tratamientos para el cáncer”, dijo su médico. 4 Le dio un folleto acerca de un estudio clínico, una opción para el tratamiento del cáncer. 5 Un estudio


Modern foraminiferal facies in a subtropical estuarine channel, Bertioga, São Paulo, Brazil  

USGS Publications Warehouse

Numerical analyses of modern foraminiferal abundance and environmental data from the Bertioga Channel (Sa??o Paulo, Brazil) reveal multiple biofacies within an overall paralic setting. Despite its fisheries, mariculture and attraction to tourists, the environmental state of Bertioga Channel remains poorly studied. The present investigation is an attempt to partly fill this gap; the parameters examined include depth, salinity, temperature, organic carbon, sulfur content and bottom sediment type. Muddy sediments with high organic carbon content derived from land drainage are found in the inner parts of the channel, whereas sandy sediment dominates the areas adjacent to the Atlantic Ocean. In the eastern entrance to the channel, sandy sediment contain species of Rotaliida from Facies 1 (including Elphidium discoidale, Elphidium poeyanum, Hanzawaia boueana, Pararotalia cananeiaensis and Nonionella atlantica), reflecting normal marine salinity. Sediments with high percentages of silt and clay in polyhaline and eurybaline environments of the eastern part and Itapanhau?? River contain Facies 2, which includes Ammonia beccarii and Pararotalia cananeiaensis. In the western entrance and central, western and eastern parts, where salinities vary from 18 to 30 psu and the sediments contain both low and high organic carbon, the foraminifera from Facies 3 are dominated by Quinqueloculina milletti, Arenoparrella mexicana, Pararotalia cananeiaensis, Ammonia beccarii, Buliminella elegantissima, Elphidium sp., Elphidium excavatum, Elphidium gunteri and Elphidium poeyanum. In mesohaline and polyhaline waters of the central part, the organic-carbon-rich silt and clay contain Facies 4, which includes Ammonia beccarii, Pararotalia cananeiaensis, Elphidium excavatum and Elphidium sp. Most of organic-carbon-enriched, silty-clay substrates that are subject to the highest fresh-water discharge and high bottom temperatures support two different assemblages: one of mostly Rotaliina and the other mostly of Textulariida (Facies 5 and 6). Facies 5 includes Ammonia beecarii, Elphidium excavatum, Arenoparrella mexicana, Haplophragmoides wilberti, Siphotrochammina lobata, Trochammina inflata and Trochammina sp., all of which are typical of mesohaline sites (mainly Crumau?? and Trindade rivers), and Facies 6 includes Bolivina sp., Ammoastuta salsa, Arenoparrella mexicana, Haplophragmoides wilberti and Trochammina sp., all of which are typical of oligohaline and mesohaline mangrove fringes. The foraminiferal species from the present study are frequently found in paralic environments in Brazil, western Africa and other estuaries around the world.

Eichler, P.P.B.; Eichler, B.B.; De Miranda, L. B.; Rodrigues, A.R.



Benthic foraminifera distribution in a tourist lagoon in Rio de Janeiro, Brazil: a response to anthropogenic impacts.  


Rodrigo de Freitas Lagoon, located in the Rio de Janeiro City, receives several types of polluted discharges. The knowledge of the sediment microfauna correlated with heavy metal and organic matter concentrations could supply important data about the conditions of the lagoon. The benthic foraminiferal assemblage presented larger diversity and more abundant samples in the lagoon entrance than in the inner area. The Ammonia tepida - Elphidium excavatum foraminiferal assemblage is characterized by dwarf, corroded and weak organisms. Agglutinated species were found only near the entrance. Low abundance values and sterility of five samples in the inner area (north/northeast) can be caused by high levels of heavy metals and organic matter. A. tepida shows negative correlation with increasing heavy metals values. PAHs and coprostanol high indexes, and the absence or low presence of microfauna in samples around the lagoon margin confirm illegal flows from gas stations and domestic sewage. PMID:21871637

Vilela, Claudia Gutterres; Batista, Daniele Silva; Baptista Neto, José Antonio; Ghiselli, Renato Olindo



New Coleoptera records from New Brunswick, Canada: Tenebrionidae and Zopheridae  

PubMed Central

Abstract Thirteen species of Tenebrionidae are newly reported for New Brunswick, Canada. Paratenetus punctatus Spinola, Pseudocistela brevis (Say), Mycetochara foveata (LeConte), and Xylopinus aenescens LeConte are recorded for the first time from the Maritime provinces. Platydema excavatum (Say) is removed from the faunal list of New Brunswick, and the presence of Platydema americanum Laporte and Brullé for the province is confirmed. This brings the total number of species of Tenebrionidae known from New Brunswick to 42. Two species of Zopheridae, Bitoma crenata Fabricius and Synchita fuliginosa Melsheimer, are newly recorded for New Brunswick, bringing the number of species known from the province to four. Bitoma crenata is new to the Maritime provinces. Collection and habitat data are presented for these species. PMID:22539897

Webster, Reginald P.; Sweeney, Jon D.; DeMerchant, Ian; Bouchard, Patrice; Bousquet, Yves



{sup 137}Cs content in the fruit bodies of various Tuber species  

SciTech Connect

In this research, the concentration of {sup 137}Cs in the fruit bodies of the Tuber species T. magnatum Pico, T. borchii Vitt., T. aestivum Vitt., and T. excavatum Vitt. collected in three different regions of Italy was determined. The values obtained have been compared to the soil concentration of {sup 137}Cs, and the transfer factor was determined. The radiocesium content of the examined fruit bodies ranged from 2.5 Bq kg{sup {minus}1} to 33.3 Bq kg{sup {minus}1} fresh weight; the median transfer factor values of the four species ranged between 0.06 and 0.6. Our findings indicate that the radiocesium level in truffles from these regions of Italy is generally low, and, thus, their consumption is not of radiological concern. The results may suggest certain hypotheses as to the mechanisms involved in radiocesium uptake in these fungi. 19 refs., 1 fig., 4 tabs.

Lorenzelli, R.; Lamma, A. [ENEA AMB-SAF, Brasimone (Italy); Zambonelli, A. [Universita di Bologna (Italy); Serra, F. [ENEA AMB-BIO, Brasimone (Italy)



Fármacos dirigidos activos contra el cáncer de seno HER-2 positivo: preguntas y respuestas

ALTTO fue un estudio clínico diseñado para determinar si la combinación del anticuerpo monoclonal trastuzumab (Herceptina) y el fármaco lapatinib (Tykerb) era más eficaz para el tratamiento del cáncer de seno HER2/ErbB2 positivo al combinarse con quimioterapia que el tratamiento con uno solo de los fármacos. Los resultados del estudio no indicaron que existan ventajas al combinar trastuzumab y lapatinib frente al tratamiento solo con trastuzumab.


On-Site Wastewater Treatment Systems: Aerobic Treatment Unit (Spanish)  

E-print Network

Sistemas individuales para el tratamiento de aguas negras Fosa de basura de un compartimiento Cloronizador Unidad de tratamiento aer?bico Rociadores Tanque bomba Unidad de tratamiento aer?bico Bruce Lesikar y Juan Enciso Promotores Especialistas de... Ingenier?a Agr?cola El Sistema Universitario Texas A&M L-5302S 8-00 Figura 1: Un sistema individual para el tratameinto de agua negras con una unidad de tratamiento aer?bico. L as unidades aer?bicas tratan las aguas negras para las casas y los negocios...

Lesikar, Bruce J.; Enciso, Juan



Complicaciones gastrointestinales (PDQ®)

Resumen de información revisada por expertos acerca del estreñimiento, impacción, obstrucción intestinal y diarrea como complicaciones del cáncer o su tratamiento. Se discute el manejo de estos problemas.


Expectations and patient satisfaction related to the use of thoracotomy and video-assisted thoracoscopic surgery for treating recurrence of spontaneous primary pneumothorax* Expectativas y satisfacción en el tratamiento del neumotórax espontáneo primario recurrente tratado por toracotomía o cirugía torácica video-asistida  

Microsoft Academic Search

Objective: To compare the outcomes of thoracotomy and video-assisted thoracoscopic surgery (VATS) in the treatment of recurrence of primary spontaneous pneumothorax. Methods: Medical records of patients presenting recurrence of primary spontaneous pneumothorax were retrospectively reviewed. Patients were divided into two groups: those who underwent conservative thoracotomy (n = 53, thoracotomy group); and those who underwent VATS (n = 47, VATS

Jorge Ramón; Lucena Olavarrieta; Pául Coronel



Expectativas y satisfacción en el tratamiento del neumotórax espontáneo primario recurrente tratado por toracotomía o cirugía torácica video-asistida* Expectations and patient satisfaction related to the use of thoracotomy and video-assisted thoracoscopic surgery for treating recurrence of spontaneous primary pneumothorax  

Microsoft Academic Search

Objective: To compare the outcomes of thoracotomy and video-assisted thoracoscopic surgery (VATS) in the treatment of recurrence of primary spontaneous pneumothorax. Methods: Medical records of patients presenting recurrence of primary spontaneous pneumothorax were retrospectively reviewed. Patients were divided into two groups: those who underwent conservative thoracotomy (n = 53, thoracotomy group); and those who underwent VATS (n = 47, VATS

Jorge Ramón; Lucena Olavarrieta; Pául Coronel




E-print Network

fuentes de aguas residuales domésticas e industriales, y la operación y mantenimiento de para ofrecer capacitación a los operadores de plantas de tratamiento de aguas residuales en México repaso general de la reglamentación mexicana para el tratamiento de descargas de aguas residuales, las


Reconstructing Long Island Sound Environmental Changes and Thier Influence on the Biota  

NASA Astrophysics Data System (ADS)

Long Island Sound (LIS) is a large urban estuary. Its environmental problems include algal blooms, leading to hypoxia and die-off of submerged aquatic vegetation and, in the last few years, significant die-off of lobsters, particularly in western LIS. We use a combination of geochemical, isotope and micropaleontological data (benthic foraminifera) on cores from Long Island Sound to investigate the environmental changes since western European settlement and industrialization, and their effects on biota. Age models are based on 210Pb, 137Cs, and pollen profiles. In LIS, seawater from the Atlantic Ocean is mixed with freshwater from the Connecticut River, Housatonic River and Thames River, resulting in salinities from 22 to 32 per mille. Benthic foraminiferal assemblages are marginally marine, and dominated by Elphidium excavatum. In the deeper parts of LIS Buccella frigida is common, and since the 1960s Ammonia beccarii has strongly increased in abundance in western LIS and shallow waters close to river mouths. The carbonate tests of Elphidium excavatum reflect a combination of salinity and temperature in their ? 18O, Sr/Ca and Mg/Ca values. The ? 13C of carbonates reflects the isotopic values of dissolved carbonate in LIS waters, which depend on the mixing proportions of river and sea water, the ? 13C of carbonate in river water, and the degree of oxidation of organic carbon in the Sound. The latter process is responsible for the seasonal hypoxia in LIS. We hypothesize that the ? 13C in foraminiferal calcite can be used as a tracer for the degree of hypoxia that was prevalent when shells were being formed, and foraminiferal assemblages in the same samples will reveal whether faunal changes occurred coeval with changes in degree of hypoxia. We established a mixing model for modern LIS through analyses of river and LIS water samples for salinity, ? 18O, dissolved carbonate, ? 13C in dissolved carbonate and Ca, Mg and Sr. Bottom water oxygen contents and temperatures were measured at the time of collection of living foraminifera. We calibrated the elemental and oxygen isotopic composition of carbonates for salinity and temperature using field measurements. We determined the difference between measured and predicted ? 13C, which is a measure of the amount of oxidized organic matter in the system. Our field results in the western part of LIS show that when oxygen levels are at or below 4mg/l, significantly lighter carbon isotopic compositions are observed than those predicted. Results from the mixing model calibrations will be applied to carbonates from 4 short cores to establish changes in temperature, salinity and dissolved oxygen in LIS over the last 400 years, and correlate these with faunal assemblage changes observed in the same samples.

Thomas, E.; Lugolobi, F.; Abramson, I.; Varekamp, J. C.



Further evidence of the importance of RIT1 in Noonan syndrome.  


Noonan syndrome (NS) is an autosomal dominant disorder consisting of short stature, short and/or webbed neck, distinctive facial features, cardiac abnormalities, cryptorchidism, and coagulation defects. NS exhibits genetic heterogeneity, associated with mutated genes that participate in RAS-mitogen-activated protein kinase signal transduction. Recently, a new gene (RIT1) was discovered as the causative gene in 17 of 180 Japanese individuals who were negative for the previously known genes for NS and were studied using exome sequencing (four patients), followed by Sanger sequencing (13 patients). The present study used the same technique in 70 Brazilian patients with NS and identified six with RIT1 missense mutations. Thus, we confirm that RIT1 is responsible for approximately 10% of the patients negative for mutations in the previously known genes. The phenotype includes a high frequency of high birth weight, relative macrocephaly, left ventricular hypertrophy, and ectodermal findings, such as curly hair, hyperpigmentation, and wrinkled palms and soles. Short stature and pectus deformity were less frequent. The majority of patients with a RIT1 mutation did not show apparent intellectual disability. Because of the relatively high frequency of mutations in RIT1 among patients with NS and its occurrence in different populations, we suggest that it should be added to the list of genes included in panels for the molecular diagnosis of NS through targeted next-generation sequencing. PMID:25124994

Bertola, Débora R; Yamamoto, Guilherme L; Almeida, Tatiana F; Buscarilli, Michelle; Jorge, Alexander A L; Malaquias, Alexsandra C; Kim, Chong A; Takahashi, Vanessa N V; Passos-Bueno, Maria Rita; Pereira, Alexandre C



Current and emerging treatments and surgical interventions for Morquio A syndrome: a review  

PubMed Central

Patients with mucopolysaccharidosis type IVA (MPS IVA; Morquio A syndrome) have accumulation of the glycosaminoglycans, keratan sulfate, and chondroitin-6-sulfate, in bone and cartilage, causing systemic spondyloepiphyseal dysplasia. Features include lumbar gibbus, pectus carinatum, faring of the rib cage, marked short stature, cervical instability and stenosis, kyphoscoliosis, genu valgum, and laxity of joints. Generally, MPS IVA patients are wheelchair-bound as teenagers and do not survive beyond the second or third decade of life as a result of severe bone dysplasia, causing restrictive lung disease and airway narrowing, increasing potential for pneumonia and apnea; stenosis and instability of the upper cervical region; high risk during anesthesia administration due to narrowed airway as well as thoracoabdominal dysfunction; and surgical complications. Patients often need multiple surgical procedures, including cervical decompression and fusion, hip reconstruction and replacement, and femoral or tibial osteotomy, throughout their lifetime. Current measures to intervene in disease progression are largely palliative, and improved therapies are urgently needed. A clinical trial for enzyme replacement therapy (ERT) and an investigational trial for hematopoietic stem cell transplantation (HSCT) are underway. Whether sufficient enzyme will be delivered effectively to bone, especially cartilage (avascular region) to prevent the devastating skeletal dysplasias remains unclear. This review provides an overview of historical aspects of studies on MPS IVA, including clinical manifestations and pathogenesis of MPS IVA, orthopedic surgical interventions, and anesthetic care. It also describes perspectives on potential ERT, HSCT, and gene therapy. PMID:24839594

Tomatsu, Shunji; Mackenzie, William G; Theroux, Mary C; Mason, Robert W; Thacker, Mihir M; Shaffer, Thomas H; Montaño, Adriana M; Rowan, Daniel; Sly, William; Alméciga-Díaz, Carlos J; Barrera, Luis A; Chinen, Yasutsugu; Yasuda, Eriko; Ruhnke, Kristen; Suzuki, Yasuyuki; Orii, Tadao



Current and emerging treatments and surgical interventions for Morquio A syndrome: a review.  


Patients with mucopolysaccharidosis type IVA (MPS IVA; Morquio A syndrome) have accumulation of the glycosaminoglycans, keratan sulfate, and chondroitin-6-sulfate, in bone and cartilage, causing systemic spondyloepiphyseal dysplasia. Features include lumbar gibbus, pectus carinatum, faring of the rib cage, marked short stature, cervical instability and stenosis, kyphoscoliosis, genu valgum, and laxity of joints. Generally, MPS IVA patients are wheelchair-bound as teenagers and do not survive beyond the second or third decade of life as a result of severe bone dysplasia, causing restrictive lung disease and airway narrowing, increasing potential for pneumonia and apnea; stenosis and instability of the upper cervical region; high risk during anesthesia administration due to narrowed airway as well as thoracoabdominal dysfunction; and surgical complications. Patients often need multiple surgical procedures, including cervical decompression and fusion, hip reconstruction and replacement, and femoral or tibial osteotomy, throughout their lifetime. Current measures to intervene in disease progression are largely palliative, and improved therapies are urgently needed. A clinical trial for enzyme replacement therapy (ERT) and an investigational trial for hematopoietic stem cell transplantation (HSCT) are underway. Whether sufficient enzyme will be delivered effectively to bone, especially cartilage (avascular region) to prevent the devastating skeletal dysplasias remains unclear. This review provides an overview of historical aspects of studies on MPS IVA, including clinical manifestations and pathogenesis of MPS IVA, orthopedic surgical interventions, and anesthetic care. It also describes perspectives on potential ERT, HSCT, and gene therapy. PMID:24839594

Tomatsu, Shunji; Mackenzie, William G; Theroux, Mary C; Mason, Robert W; Thacker, Mihir M; Shaffer, Thomas H; Montaño, Adriana M; Rowan, Daniel; Sly, William; Alméciga-Díaz, Carlos J; Barrera, Luis A; Chinen, Yasutsugu; Yasuda, Eriko; Ruhnke, Kristen; Suzuki, Yasuyuki; Orii, Tadao



Spondyloepimetaphyseal dysplasia with joint laxity (SEMDJL): clinical and radiological findings in a Guatemalan patient.  


We report on a patient of Guatemalan descent whose physical and radiological findings are consistent with a diagnosis of spondyloepimetaphyseal dysplasia with joint laxity (SEMDJL). This is a rare, autosomal recessive skeletal dysplasia with short limbs, severe scoliosis, high dorsal kyphoscoliosis, and joint hypermobility. Most described patients with SEMDJL are from the Afrikaans-speaking communities of South Africa. Patients with SEMDJL have an oval face, prominent eyes, and blue sclerae. Our patient's height and weight were below the fifth centile. She had prominent eyes with blue sclerae, a narrow, high-arched palate, pectus carinatum, severe scoliosis, and hyperextensibility and instability of most joints, with limited extension and supination of her elbows. A review of her roentgenograms showed severe scoliosis, poorly developed ischial, iliac, and pubic bones, a "bat-like" appearance of the iliac bones, "dysplastic" acetabulum, minimal metaphyseal and epiphyseal abnormalities at the knees, deformation of the proximal femoral metaphyses, and generalized brachydactyly of the hands and feet. This disorder may be more common than previously thought, and the diagnosis should be considered in any child with a dwarfing condition and joint laxity. PMID:8588592

Bradburn, J M; Hall, B D



Benthic foraminifers on the continental shelf and upper slope, Russian River area, northern California ( USA).  

USGS Publications Warehouse

We analyzed benthic foraminifers from 71 surface samples collected from the sea floor of the continental margin. One hundred and six different taxa were identified, and Q-mode factor analysis was used to identify assemblages. Six foraminiferal assemblage factors explain 94% of the variation in the data matrix. The Inner Shelf Assemblage is characterized by Trichohyalus ornatissima, Rotalia columbiensis, Cassidulina limbata, Cibicides fletcheri, Elphidiella hannai and Elphidium sp. 1 and occupies water depths less than 50 m. The Middle Shelf Assemblage is characterized by Nonionella basispinata, Elphidium excavatum and Florilus labradoricus and occupies water depths between 50 and 90 m. A Middle Shelf to Upper Bathyal Assemblage is characterized by Uvigerina juncea, Globobulimina spp. and Nonionella basispinata and occupies depths between about 90 and 450 m. Two overlapping assemblages make up the Upper Middle Bathyal Assemblage and are most abundant between water depths of 500 and 1300 m. They are associated with low- oxygen conditions. The Mid-Bathyal Assemblage is dominated by Uvigerina proboscidea and occurs on the slope at water depths ranging from 1200 to 2500 m. -from Authors

Quinterno, P.J.; Gardner, J.V.



First Molecular Identification and Genetic Characterization of Theileria lestoquardi in Sheep of the Maghreb Region.  


Theileria lestoquardi is the most prominent Theileria species in small ruminants that causes malignant theileriosis of sheep in Africa and Asia. In the present survey, blood samples and ticks were collected in Kebili (southern Tunisia) from 166 Queue Fine de l'Ouest sheep. Giemsa-stained blood smears, immunofluorescent antibody test (IFAT) and PCR were performed. The DNA was extracted from blood and analysed by PCR targeting 18S rRNA gene of Theileria spp. and then sequenced. A total number of 140 ticks were collected from a total number of 166 sheep during the four seasons. The ticks belonged to two genera and 4 species; the most frequent tick was Hyalomma excavatum 84.3% (118/140) and then Rhipicephalus spp. 15.7% (22/140). Only two animals had positive Giemsa-stained blood smears, and they were also positive by IFAT. The amplicons had 99.3 and 99.6% homology with the BLAST published T. lestoquardi amplicons. To our knowledge, this is the first report of T. lestoquardi in small ruminants within the Maghreb region. PMID:25208526

Rjeibi, M R; Darghouth, M A; Rekik, M; Amor, B; Sassi, L; Gharbi, M



Benthonic foraminiferal faunal and isotopic data for the postglacial evolution of the Champlain Sea*1  

NASA Astrophysics Data System (ADS)

Benthonic foraminiferal faunal and isotopic data from Champlain Sea sediments (approximately 12,500 to 10,000 yr B.P. in age) in two piston cores from Lake Champlain provide a detailed, apparently continuous record of the evolution of the Champlain Sea. Cassidulina reniforme and Islandiella helenae are the dominant benthonic foraminifera during the initial phase of the Champlain Sea, and are replaced by Elphidium excavatum forma clavatum and Protelphidium orbiculare as the dominant species during the remainder of the sea's history. The oxygen-isotopic data show a gradual decrease in ?18O between approximately 12,500 and 10,900 yr B.P., followed by a more rapid decrease during the interval 10,900 to 10,000 yr B.P. The ?13C data have a similar trend as ?18O, with generally decreasing values up the section. The isotopic and faunal data suggest that nearly marine conditions were present in the initial plase of the Champlain Sea, followed by gradually decreasing salinities and increasing temperatures as the sea evolved. The beginning of the rapid isotopic decrease at approximately 10,900 yr B.P. marks the onset of the largest environmental change in the history of the Champlain Sea, probably reflecting a major pulse of meltwater from the Laurentide Ice Sheet.

Corliss, Bruce H.; Hunt, Allen S.; Keigwin, Lloyd D.



A global meta-analysis of Tuber ITS rDNA sequences: species diversity, host associations and long-distance dispersal.  


Truffles (Tuber) are ectomycorrhizal fungi characterized by hypogeous fruitbodies. Their biodiversity, host associations and geographical distributions are not well documented. ITS rDNA sequences of Tuber are commonly recovered from molecular surveys of fungal communities, but most remain insufficiently identified making it difficult to determine whether these sequences represent conspecific or novel taxa. In this meta-analysis, over 2000 insufficiently identified Tuber sequences from 76 independent studies were analysed within a phylogenetic framework. Species ranges, host associates, geographical distributions and intra- and interspecific ITS variability were assessed. Over 99% of the insufficiently identified Tuber sequences grouped within clades composed of species with little culinary value (Maculatum, Puberulum and Rufum). Sixty-four novel phylotypes were distinguished including 36 known only from ectomycorrhizae or soil. Most species of Tuber showed 1-3% intraspecific ITS variability and >4% interspecific ITS sequence variation. We found 123 distinct phylotypes based on 96% ITS sequence similarity and estimated that Tuber contains a minimum of 180 species. Based on this meta-analysis, species in Excavatum, Maculatum and Rufum clades exhibit preference for angiosperm hosts, whereas those in the Gibbosum clade are preferential towards gymnosperms. Sixteen Tuber species (>13% of the known diversity) have putatively been introduced to continents or islands outside their native range. PMID:21040049

Bonito, Gregory M; Gryganskyi, Andrii P; Trappe, James M; Vilgalys, Rytas



Dinoflagellate resting cysts as factors in phytoplankton ecology of the North Sea  

NASA Astrophysics Data System (ADS)

The occurrence and distribution of dinoflagellate resting cysts were investigated at 11 locations in the south-eastern part of the North Sea. Twenty-six known cyst species and 7 unknown cyst types, which may act as seed population for planktonic dinoflagellate blooms, have been recorded for the first time in the area. The most common cysts in recent sediments were those of Scrippsiella trochoidea, Zygabikodinium lenticulatum, Peridinium dalei, Scrippsiella lachrymosa, Protoceratium reticulatum, Protoperidinium denticulatum, and P. conicum. At all stations, S. trochoidea dominated the cyst assemblages with a maximal abundance of 1303 living cysts/cm3 in the uppermost half centimetre. Cysts of the potentially toxic dinoflagellates Alexandrium cf. excavatum and A. cf. tamarense were scarce. In the upper 2-cm layer of sediment, dinoflagellate cysts were found in concentrations of 1.8 up to 682 living cysts/cm3. Empty cysts constituted 22 56% of total cyst abundance. The comparative distribution of the cysts showed a general increase in abundance from inshore sites to the offshore area, whereby sandy stations exhibited the lowest cyst abundance and diversity. The wide distribution of living and empty cysts of Scrippsiella lachrymosa suggests that its motile form, which has not been officially recorded in the area until now, is a common plankton organism in German coastal waters. The relatively high abundance of cysts in recent sediments demonstrates the potential importance of benthic resting stages for the initiation of dinoflagellate blooms in the study area.

Nehring, S.



Ticks (Ixodidae) on migrating birds in Egypt, spring and fall 1962*  

PubMed Central

Over a number of years studies have been carried out in Egypt on the transport by migrating birds of ticks that may transmit pathogens of man and animals. In continuation of these investigations 11 036 birds migrating southwards through Egypt were examined for ticks during the fall of 1962. The 881 infested birds (comprising 24 species and sub-species represented by 10 612 individuals) yielded 1442 ticks. Tick-host relationships were similar to those of previous years except that in 1962 the prevalence of infestation was almost invariably much higher than the averages for 1959-61. Five species of birds were added to the previous list of 40 infested forms. Previously unrecorded tick species taken during 1962 were Ixodes redikorzevi (a species from Asia very occasionally found in rodent burrows in Egypt), the rare Haemaphysalis inermis, and Hyalomma a. anatolicum, H. anatolicum excavatum and H. dromedarii, which may have been carried from Asia or have attached themselves to the birds at the time of netting. During the spring of 1962, altogether 1774 birds migrating northwards through Egypt were also examined. The 56 tick-infested birds (comprising 13 species represented by 867 individuals) yielded 186 ticks. As in previous years, Hyalomma marginatum rufipes was the chief species (89.25%) parasitizing spring migrants. A single specimen of Amblyomma variegatum was taken on Anthus cervinus and 19 specimens of Ixodes?sp. nov. were collected from Sylvia c. communis and Motacilla a. alba. PMID:14163959

Hoogstraal, Harry; Traylor, Melvin A.; Gaber, Sobhy; Malakatis, George; Guindy, Ezzat; Helmy, Ibrahim



Selection of a set of specific primers for the identification of Tuber rufum: a truffle species with high genetic variability.  


Tuber rufum is a truffle widely distributed throughout Europe, which forms mycorrhizal associations with numerous species of broadleaf and coniferous trees. The possibility of T. rufum contamination in commercial truffle-infected plants makes its detection important. To facilitate the identification of T. rufum from mycorrhiza and fruitbodies, species-specific primers were designed and tested. To overcome the high intraspecific genetic variability within the internal transcribed spacer (ITS) regions of T. rufum, as demonstrated by phylogenetic analysis, two forward primers, Ru1f and Ru2f, located on the ITS1 region were designed to be used in concert with the reverse primer ITS4. Only T. rufum was amplified with this primer combination, while DNA of Tuber magnatum, Tuber brumale, Tuber maculatum, Tuber borchii, Tuber excavatum and Tuber melanosporum was not. These primers give a specific amplicon ranging between 566 and 572 bp and are able to discriminate between T. rufum, T. borchii and T. magnatum in multiplex PCR. In addition, T. rufum-specific amplicons were obtained from both spore suspensions and mycorrhiza by direct PCR. Tuber rufum mycorrhiza obtained in the greenhouse using mycelial inoculation techniques had morphological features similar to those of other species of Tuber, stressing the importance of molecular tools for their identification. PMID:18031344

Iotti, Mirco; Amicucci, Antonella; Bonito, Gregory; Bonuso, Enrico; Stocchi, Vilberto; Zambonelli, Alessandra



Improved resolution of major clades within Tuber and taxonomy of species within the Tuber gibbosum complex.  


Tuber gibbosum Harkn., described from northern California, originally was thought to be a single, variable species that fruited from autumn through winter to spring. It has become popular as a culinary truffle in northwestern USA, where it is commercially harvested. Morphological studies suggested it might be a complex that includes at least two species. We conducted morphological and phylogenetic studies of the complex to determine how many species it might contain and how they differed morphologically, geographically and seasonally. We also provide the first LSU phylogeny for the genus Tuber. Phylogenetic analyses resolve nine major clades in the genus with high bootstrap support and distinguish the Gibbosum clade from the Aestivum, Excavatum, Macrosporum, Magnatum, Melanosporum, Puberulum, Rufum and Spinoreticulatum clades. Further analyses of ITS and LSU regions revealed four distinct species in the Gibbosum complex. Although morphologically similar the four species differ in spore size and shape and in peridial anatomy. These species share the synapomorphy of having suprapellis hyphae with distinctive, irregular wall swellings at maturity; we have not seen this hyphal type in any other Tuber spp. worldwide. The three new species are named and described as T. bellisporum Bonito & Trappe, T. castellanoi Bonito & Trappe and T. oregonense Trappe, Bonito & Rawlinson. PMID:20943504

Bonito, Gregory; Trappe, James M; Rawlinson, Pat; Vilgalys, Rytas



The Integration of Focusing-oriented Psychotherapy into the Three-phase Model for the Treatment of Post-traumatic Stress Disorder \\/ Die Integration Focusing-Orientierter Psychotherapie in das Drei-Phasen-Modell für die Behandlung der Posttraumatischen Belastungsstörung \\/ La integración de la psicoterapia orientada al focusing en el modelo de tres fases para el tratamiento del estrés post traumático \\/ De integratie van focusinggeoriënteerde psychotherapie in het driefasenmodel voor de behandeling van de posttraumatische stressstoornis  

Microsoft Academic Search

Focusing is a suitable method for the treatment of adults suffering from post-traumatic stress disorder (PTSD). Most theorists regard the general three-phase model for the treatment of PTSD, proposed by Janet and Herman amongst others, as a general, standard model. In the literature, no description of the integration of focusing-oriented psychotherapy within the three-phase model for the treatment of PTSD

Peter Scharwächter




E-print Network

prairie dog colonies, whereas abundances of North American deermice (Peromyscus maniculatus) and plains maniculatus) y del rato´n cosechador (Reithrodontomys montanus) no variaron entre tratamientos. La abundancia

Wallace, Mark C.


El cáncer según su ubicación en el cuerpo

Lista de todos los tipos de cáncer, organizados por ubicación o función en el cuerpo. Los cánceres que hay en esta lista tienen enlaces a información sobre tratamientos, cuidados de apoyo, exámenes de detección, prevención, estudios clínicos y otros temas.


El cáncer

Información para mejorar sus conocimientos sobre el cáncer, que incluye las formas de prevenir el cáncer, la importancia de visitar al médico regularmente y hacerse exámenes de detección, y las diferentes opciones de tratamiento disponibles.


Terapia hormonal para el cáncer de próstata

Hoja informativa que describe la terapia hormonal y su función en el tratamiento del cáncer de próstata. Incluye información acerca de los tipos diferentes de terapia hormonal, cómo se usan y los efectos secundarios posibles.


El NCI inicia un estudio para evaluar la utilidad de la secuenciación genética para mejorar los resultados en los pacientes

El Instituto Nacional del Cáncer (NCI) lanzará este mes un estudio clínico piloto denominado M-PACT con la finalidad de evaluar si el tratamiento asignado según mutaciones genéticas específicas puede brindar beneficios a pacientes con tumores sólidos metastásicos.


Tomografía computarizada (TC) y exploraciones para cáncer

Hoja informativa que describe el procedimiento y la tecnología de exploraciones con tomografía computarizada así como sus usos para el diagnóstico, para exámenes de detección y para tratamiento del cáncer.


Lo que usted necesita saber sobre™ el cáncer de cérvix

Contiene información sobre las opciones de tratamiento, la obtención de una segunda opinión, los cuidados de seguimiento y las fuentes de apoyo para alguien que ha sido diagnosticado recientemente con cáncer de cérvix o cuello uterino.


Terapia hormonal para el cáncer de seno

Hoja informativa que describe la terapia hormonal y su función en la prevención y tratamiento del cáncer de seno. Incluye información acerca de los efectos secundarios posibles y de los fármacos que pueden interferir con la terapia hormonal.


FAQ: General Questions about West Nile Virus  


... been documented in Europe and the Middle East, Africa, India, parts of Asia, and Australia. It was ... y control Symptoms & Treatment Síntomas y tratamiento Transmission Statistics & Maps Preliminary Maps & Data for 2014 Disease Cases ...


Fatiga (PDQ®)

Resumen de información revisada por expertos acerca de la fatiga, una afección caracterizada por extremo cansancio e incapacidad para funcionar por la falta de energía, que a menudo se observa como una complicación del cáncer y su tratamiento.


Linfedema (PDQ®)

Resumen de información revisada por expertos sobre la anatomía, la patofisiología, las manifestaciones clínicas, el diagnóstico y el tratamiento del linfedema relacionado con el cáncer, una afección en la que se acumula líquido linfático en los tejidos y causa inflamación..


Náuseas y vómitos (PDQ®)

Resumen de información revisada por expertos acerca de las náuseas y los vómitos como complicaciones a causa del cáncer o su tratamiento. Se discuten enfoques sobre el manejo de las náuseas y los vómitos.


Delirio (PDQ®)

Resumen de información revisada por expertos acerca del delirio como una complicación a causa del cáncer o su tratamiento. Se discuten los enfoques de los cuidados médicos de apoyo, asi como farmacológicos para el manejo del delirio.


Rotavirus Treatment  


... Rotavirus Vaccine Program American Academy of Pediatrics Treatment Language: English Español (Spanish) Share Compartir Español: Tratamiento There ... PATH's Rotavirus Vaccine Program American Academy of Pediatrics Language: English Español (Spanish) File Formats Help: How do I ...


Consejos para pacientes que reciben radioterapia

Serie de nueve (9) hojas sobre los efectos secundarios de la radioterapia. Cada hoja contiene recomendaciones y sugerencias prácticas para ayudarle a controlar los efectos secundarios durante la radioterapia, y a que se sienta mejor durante el tratamiento.


Delirio (PDQ®)

Resumen de información revisada por expertos acerca del delirio como una complicación del cáncer o su tratamiento. Se tratan enfoques de los cuidados médicos de apoyo y los abordajes farmacológicos para el manejo del delirio.


Cómo cuidarse mientras usted cuida a su ser querido: Apoyo para personas que cuidan a un ser querido con cáncer

Un folleto para las personas responsables del cuidado de un ser querido que recibe tratamiento para el cáncer. Ofrece información práctica y apoyo para ayudarlas a sobrellevar este período difícil y estresante.


On-Site Wastewater Treatment Systems: Evapotranspiration Bed (Spanish)  

E-print Network

Fosa s?ptica de dos compartimentos Suelo arcilloso Piedra quebrada Cama de evapotranspiraci?n Mecha de absorci?n Sistemas individuales para el tratamiento de aguas negras Cama de evapotranspiraci?n Bruce Lesikar y Juan Enciso Promotores...

Lesikar, Bruce J.; Enciso, Juan



Recursos en su comunidad

Información acerca de las organizaciones que proporcionan apoyo a personas con cáncer. También incluye recursos disponibles en la comunidad, como doctores, centros de tratamiento y otros profesionales de salud.


Consejos para pacientes que reciben quimioterapia

Serie de dieciocho (18) hojas sobre los efectos secundarios de la quimioterapia. Cada hoja contiene recomendaciones y sugerencias prácticas para ayudarle a controlar los efectos secundarios durante la quimioterapia, y a que se sienta mejor durante el tratamiento.


Nueva Publicacion Habla de las Necesidades de los Sobrevivientes de cancer Latinos y sus Familias

Esta publicación gratuita combina la información más actual de los profesionales de la salud con anécdotas personales de sobrevivientes de cáncer latinos, sobre cómo enfrentarse a la vida después del tratamiento del cáncer


Consejos para cuando le duelan la boca o la garganta

Información para personas que están recibiendo radioterapia y consejos sobre cómo controlar las molestias en la boca y garganta, sentirse mejor durante el tratamiento y comunicarse con su doctor o enfermera.


PROGRAMA DE MAESTRA Y DOCTORADO EN INGENIERA Subcomit Acadmico por Campo del Conocimiento  

E-print Network

para tratamiento de aguas residuales Dr. Simón González y Dr. Oscar González (Campus CU) Dra. Gabriela aguas residuales Dr. Pedro Martínez Pereda y Dr. Eduardo Vega (Campus CU) Dr. Simón González y Dr. Oscar) Tratamiento anaerobio de aguas residuales y lodos Dr. Adalberto Noyola (Campus CU) y Dr. Juan Manuel Morgan

Islas, León


Recursos relacionados con los exámenes de detección del cáncer de cuello uterino

El NCI tiene información completa y de base científica sobre prevención, exámenes selectivos de detección, diagnóstico, tratamiento, genética y cuidados de apoyo relacionados con el cáncer. Nuestros especialistas en información pueden responder preguntas relacionadas con el cáncer, entre ellas, las que tienen que ver con los exámenes de detección y el tratamiento del cáncer de cuello uterino. Puede comunicarse con nosotros por teléfono, correo electrónico o mensajería instantánea (el chat solo está disponible en inglés).


Un estudio financiado por los Institutos Nacionales de la Salud (NIH) muestra reducción en la mortalidad entre hombres con cáncer de próstata en grado intermedio:

Terapia hormonal por corto tiempo administrada en combinación con radioterapia a hombres con cáncer de próstata en estadio inicial aumentó sus posibilidades de vivir más en comparación con tratamiento de radioterapia sola, según un estudio clínico patrocinado por el NCI. Los beneficios del tratamiento combinado se limitaron principalmente a pacientes con enfermedad de riesgo intermedio y no se observaron en hombres con cáncer de próstata de riesgo bajo, indican los investigadores.


Long Island Sound: a Human Dominated Environment  

NASA Astrophysics Data System (ADS)

Long Island Sound (LIS) is a marginally marine urban estuary, with Long Island (NY) as its southern coastline, New York and Connecticut along its northern coast. LIS has a narrow opening to the West (East River), but most exchange with the ocean occurs at its eastern end, resulting in an east-west gradient in salinity. There is also an east-west gradient in indicators of contamination in the surface sediments (e.g., trace metals). Western LIS is close to the main population center (New York City), but also is a focusing region for fine- grained sediments. Since the 1970s, western LIS and to a lesser extent, central LIS, suffer summer hypoxia or even anoxia. We used sediment cores in westernmost and central LIS to document environmental changes over the last millennium, including the time of European settlement, using microfossil, geochemical, sedimentological, and trace element proxies. Sediment ages were determined using metal pollution records and radiometric carbon dating. Before European settlement, the low-diversity benthic faunas were dominated by Elphidium excavatum (feeding on diatoms) at shallow depths (< 12 m, where light penetrates to the bottom), by Elphidium incertum in westernmost LIS and by Buccella frigida and/or Eggerella advena over most of LIS at greater depths. In almost all cores, the absolute abundance of benthic foraminifera and the relative abundance of Elphidium excavatum increased from the early-mid 1800s on. The faunal changes coincided with an increase in contaminant trace metal concentration, with human population growth in the region, with a marked decrease in salinity in westernmost LIS, and with the beginning of low oxygen conditions as indicated by carbon isotope values in foraminiferal tests. At the same time, accumulation rates of organic carbon and nitrogen increased several fold, most extremely so in westernmost LIS. These data thus all indicate that humans influenced LIS and its ecosystems from the mid 19th century on, causing eutrophication, increased fresh water run-off due to urbanization and possibly re-routing of fresh water through waste water treatment plants, and increased organic carbon and trace metal storage in the sediments. A period of additional faunal changes started in the late 1960s, when overall foraminiferal abundance decreased, but Ammonia parkinsoniana, formerly absent or rare, became common to dominant especially in western LIS. This last faunal change might have resulted from even more increased eutrophication, with high N/Si values resulting in decreased dominance of primary producers by diatoms, affecting organisms that feed on them and thus reverberating through the whole ecosystem. We thus document a coastal ecosystem that changed significantly with human population growth in the middle 1800s, and again with more severe eutrophication over the last few decades.

Thomas, E.; Varekamp, J. C.



Natural history and clinical assessment of Taiwanese patients with mucopolysaccharidosis IVA  

PubMed Central

Background Mucopolysaccharidosis IVA (MPS IVA) is a rare lysosomal storage disorder caused by N-acetylgalactosamine-6-sulfatase deficiency, which catalyzes a step in the catabolism of glycosaminoglycans, keratan sulfate and chondroitin-6-sulfate. This disease has a variable age of onset and rate of progression. Methods A retrospective analysis of medical records of 24 patients with MPS IVA (11 males, 13 females; current mean age?±?SD, 12.6?±?6.6 years; age range, 1.4-29.4 years) seen at 6 medical centers in Taiwan from January 1996 through June 2013 was performed. Results Mean ages of onset of symptoms and confirmed diagnosis were 2.0?±?1.6 and 5.7?±?4.5 years, respectively. The most prevalent clinical manifestations were kyphosis (100%), pectus carinatum (96%), abnormal gait (93%), striking short trunk dwarfism (92%), genu valgum (92%), and valvular heart disease (91%). Eight patients (33%) experienced at least one surgical procedure with the most common being ear tube insertion (25%), adenoidectomy (17%), tonsillectomy (13%), supraglottoplasty (13%), spinal decompression (13%), and spinal fusion (13%). The most prevalent cardiac valve abnormalities were aortic stenosis (45%) and mitral regurgitation (45%). At the time of the study, 8 out of 24 patients (33%) have died at the mean age of 17.2?±?7.7 years. Conclusions An understanding of the natural history involved in MPS IVA may allow early diagnosis of the disease. All affected Taiwanese patients experienced significant functional limitations. Adequate evaluations and timely management may improve clinical outcomes and quality of life. PMID:24513086



Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome  

SciTech Connect

Nevoid basal cell carcinoma syndrome (NBCC; Gorlin syndrome), an autosomal dominant disorder linked to 9q22.3-q31, and caused by mutations in PTC, the human homologue of the Drosophila patched gene, comprises multiple basal cell carcinomas, keratocysts of the jaw, palmar/plantar pits, spine and rib anomalies and calcification of the falx cerebri. We reviewed the findings on 105 affected individuals examined at the NIH since 1985. The data included 48 males and 57 females ranging in age from 4 months to 87 years. Eighty percent of whites (71/90) and 38% (5/13) of African-Americans had at least one basal cell carcinoma (BCC), with the first tumor occurring at a mean age of 23 (median 20) years and 21 (median 20) years, respectively. Excluding individuals exposed to radiation therapy, the number of BCCs ranged from 1 to >1,000 (median 8) and 1 to 3 (median 2), respectively, in the 2 groups. Jaw cysts occurred in 78/105 (74%) with the first tumor occurring in 80% by the age of 20 years. The number of total jaw cysts ranged from 1 to 28 (median 3). Palmar pits and plantar pits were seen in 87%. Ovarian fibromas were diagnosed by ultrasound in 9/52 (17%) at a mean age of 30 years. Medulloblastoma occurred in 4 patients at a mean age of 2.3 years. Three patients had cleft lip or palate. Physical findings include {open_quotes}coarse face{close_quotes} in 54%, relative macrocephaly in 50%, hypertelorism in 42%, frontal bossing in 27%, pectus deformity in 13%, and Sprengel deformity in 11%. This study delineates the frequency of the clinical and radiological anomalies in NBCC in a large population of US patients and discusses guidelines for diagnosis and management. 48 refs., 3 figs., 5 tabs.

Kimonis, V.E.; Yang, M.L.; Bale, S.J. [National Institute of Arthritis and Musculoskeletal and Skin Disease, Bethesda, MD (United States)] [and others] [National Institute of Arthritis and Musculoskeletal and Skin Disease, Bethesda, MD (United States); and others



[Natural history of Morquio A disease].  


Type IV mucopolysaccharidosis (Morquio A syndrome; MPS IVA; OMIM 253000), is a multisystemic, severe and very disabling disease, also life-threatening; MPS IVA is due to a deficiency of the enzyme N-acetylgalactosamine-6-sulfate sulfatase (GALNS), a lysosomal enzyme responsible for the degradation of keratan sulfate (KS) and chondroitin-6-sulfate (C6S). The disease is characterized by respiratory, pulmonary manifestations and also causes bone involvement with progressive spondyloepimetaphyseal degradation and mild and late-onset ophthalmologic, hearing and cardiac complications. These manifestations progressively impair the patients' physical mobility. Severe forms of the disease, diagnosed before the age of 1 year, can be distinguished from intermediary (diagnosed between 1 and 5 years old) and attenuated disease, diagnosed after the age of 5 years (occasionally far later). The main signs are bone deformities namely pectus carinatum, kyphoscoliosis and genu valgum, with early flattening of the growth curve, leading rapidly to almost complete growth arrest. Patients have normal cognitive development. The radiological signs are relatively specific with, in particular, platyspondyly, shortening of the long bones and characteristic pelvic changes. The diagnosis is suggested by elevated urinary GAGs level and profile, and is confirmed by GALNS enzymatic studies on molecular testing. Genetic counseling is important in this autosomal recessive disorder and enzymatic and/or molecular testing can be offered for prenatal diagnosis. Management is mostly symptomatic, based on early detection and orthopedic correction of spine and lower limb deformities, ENT and respiratory management and psychological, social and educational support for the child and his/her family. PMID:25063382

Baujat, G; Valayannopoulos, V



Benthic foraminifera record and geochemical studies to reconstruct the recent (~400 ya) paleoenvironment of Tomales Bay, California  

NASA Astrophysics Data System (ADS)

We are conducting investigations of calcareous benthic foraminifera acquired from Tomales Bay, California to reconstruct geochemical conditions of the bay for the past ~400 years, a time period of both natural and anthropogenic environmental change. Tomales Bay, located ~50km northwest of San Francisco, is a long (20.4 km), narrow (0.7 - 1.7 km) and shallow (2.0 - 6.0 m) bay that exhibits long-residence times and is stratified in the summer due to seasonal hypersalinity. Tomales Bay is a unique environment for climate and environmental change research because of the wide documented variability in carbonate parameters (pH, alkalinity, DIC) due to freshwater input from terrestrial sources that decreases aragonite and calcite saturation states. The historical record provided by benthic foraminiferal species and geochemistry, sedimentary carbon (TOC and TIC) analyses, and investigations of recent (Rose-Bengal stained) foraminifera are being utilized to constrain 3 major processes: 1) the range of temperature and salinity shifts over the past 400 years, 2) the relative dominance of marine- vs. fresh-water sources to the bay, and 3) the extent to which freshwater input and runoff may influence water chemistry (saturation state, ?) with impacts on foraminiferal calcification. Four sediment cores were acquired in 2009 and 2010, and subsequently age-dated utilizing radiocarbon analyses (seven samples). Results indicate an increase in preservation of agglutinated versus calcareous foraminiferal tests (shells) since the mid-1900’s, and greater abundances of agglutinated tests found near freshwater sources. The major calcareous foraminifera present in the record include Elphidium hannai, Elphidium excavatum, Ammonia tepida, and Buccella frigida. Results from oxygen and carbon stable isotope analyses as well as total organic carbon (by weight) for all the cores will also be presented. These results will be compared to modern observations and instrumental records of temperature, salinity and pH variability to understand the context of historical changes compared to modern shifts due to human influence.

Flores, S. C.; Hill, T. M.; Russell, A. D.; Brooks, G.



A survey of ixodid tick species and molecular identification of tick-borne pathogens.  


This study was undertaken in two different climatic areas of Turkey to determine the presence of tick-borne pathogens of medical and veterinary importance. The ticks were removed from humans, pooled according to species and developmental stages, and analyzed by PCR, reverse line blot (RLB) and sequencing. Of the 2333 removed ticks from 10 species, 1238 (53.06%) were obtained from the arid cold zone, and the remaining 1095 (46.93%) were obtained from the humid zone. The removed ticks were identified as Hyalomma marginatum, Hyalomma detritum, Hyalomma excavatum, Rhipicephalus bursa, Rhipicephalus turanicus, Rhipicephalus sanguineus, Dermacentor marginatus, Haemaphysalis punctata, Haemaphysalis sulcata, Ixodes ricinus, Haemaphysalis and Ixodes spp. nymphs. The dominant species was I. ricinus (61.27%) in the humid zone, whereas the Haemaphysalis spp. nymph dominated (30.29%) in the arid zone. Infection rates were calculated as the maximum likelihood estimation (MLE) with 95% confidence intervals (CI). Of the 169 pools tested, 49 (28.99%) were found to be infected with the pathogens, and the overall MLE of the infection rate was calculated as 2.44% (CI 1.88-3.17). The MLE of the infection varied among tick species, ranging from 0.85% (CI 0.23-2.34) in Haemaphysalis spp. nymph to 17.93% (CI 6.94-37.91) in D. marginatus. Pathogens identified in ticks included Theileria annulata, Babesia ovis, Babesia crassa, Anaplasma/Ehrlichia spp., Anaplasma ovis, Ehrlichia canis, Anaplasma phagocytophilum, Hepatozoon canis and Hepatozoon felis. Most tick pools were infected with a single pathogen. However, four pools infected with H. canis displayed infections with B. crassa, A. phagocytophilum and E. canis. The sequencing indicated that Anaplasma/Ehrlichia spp. was 100% identical to the sequence of Ehrlichia sp. Firat 2 and 3 previously identified from Hyalomma anatolicum. PMID:24424312

Aktas, Munir



Hard Tick Species of Livestock and their Bioecology in Golestan Province, North of Iran  

PubMed Central

Background A survey on tick species composition was carried out in Golestan Province Iran during year 2010–2011.The aim was to determine tick species parasitizing domestic ruminants and their seasonal population dynamics. Methods: A total of 124 sheep, 92 goats, 84 cattle, 74 camels and 12 horses in several villages were inspected for tick infestation. The collected ticks preserved in 70% alcohol and then were identified. Results: The overall 1059 ticks (453 female, 606 male) were collected. The ticks occur on sheep, goats, cattle, camels and horses as 72.1%, 77.3%, 75.8%, 69.3%, and 50% respectively. The frequency of ticks in spring was more than other seasons and the least was observed in winter. In the spring and summer, infestation rate in domestic ruminants were calculated as 100%. Six genus and fourteen hard and soft tick species were identified including Rhipicephalus sanguineus, R. bursa, Ixodes ricinus, Haemaphysalis punctata, H. sulcata, H. erinacei, H. inermis, Hyalomma marginatum, Hy. asiaticum, Hy. dromedarii, Hy. excavatum, Hy. anatolicum, Hy. detritum, Boophilus annulatus and Argas persicus. Rhipicephalus sanguineus was the most abundant species in the study area. The largest number of ticks was collected from animal ears and tails. Haemaphysalis, Hyalomma, Rhipicephalus and Boophilus occurred in mountainous, forest and plateau areas of Golestan Province but Ixodes occurred only in mountainous and forest areas, whereas Rhipicephalus and Hyalomma were present in coastal areas of Golestan Province. Conclusion: The result of this study is a survey on tick species from domestic animals in Iran and implication of possible prevention measures for diseases transmitted by ticks.

Sofizadeh, Aioub; Telmadarraiy, Zakkyeh; Rahnama, Abbas; Gorganli-Davaji, Ahmad; Hosseini-Chegeni, Asadollah



Neuroimagen en la enfermedad de Alzheimer: nuevas perspectivas  

PubMed Central

Introducción y desarrollo En los próximos 50 años vamos a presenciar un incremento significativo de la población mayor de 65 años y por lo tanto va a aumentar, considerablemente, el número de individuos con riesgo de desarrollar demencias neurodegenerativas, especialmente la enfermedad de Alzheimer (EA). Las estrategias actuales de tratamiento farmacológico y no farmacológico se han centrado en las fases sintomáticas de esta enfermedad y, gradualmente, vamos teniendo una mayor comprensión de los posibles factores de riesgo del síndrome clínico. Conclusiones Los estudios de neuroimagen han sido muy útiles para mostrar los cambios estructurales del envejecimiento normal y patológico, así como también los factores de riesgo para la EA. Los tratamientos apropiados de los factores de riesgo y su posible combinación con tratamientos específicos para la EA podrían prolongar el período presintomático de la EA y, por tanto, mejorar la calidad de vida y disminuir la carga para el paciente, la familia y la sociedad. PMID:20517866

Becker, James T.



Estudio de terapias dirigidas para el cáncer de seno estableció un modelo de estudios clínicos a nivel mundial

Dos medicamentos de acción dirigida, diseñados para tratar una forma agresiva de cáncer de seno (mama), se pusieron a prueba en un estudio que incluyó a 8 000 participantes en 44 países. Si bien la finalidad del estudio fue ayudar a que los investigadores determinaran si el tratamiento combinado con trastuzumab y lapatinib para el tratamiento del cáncer de seno HER2 positivo en estado inicial era mejor que la terapia solo con trastuzumab, los resultados del estudio no indicaron que existan ventajas para las mujeres al recibir la combinación de fármacos de trastuzumab o lapatinib.


El análisis de un estudio clínico indica que una combinación de fármacos puede ser de gran eficacia contra el cáncer de ovario recidivante

El uso de un tratamiento farmacológico combinado para el cáncer de ovario recidivante mostró mejorías significativas, según se informó el día de hoy en el congreso anual de la Sociedad Americana de Oncología Clínica (ASCO). La combinación farmacológica se evaluó en un estudio de fase I y posteriormente en un estudio clínico aleatorizado de fase II patrocinado por el Instituto Nacional del Cáncer (NCI).


Lo que usted necesita saber sobre™ el cáncer de seno

Contiene información sobre las opciones de tratamiento, los diferentes médicos que tratan el cáncer de seno, la obtención de una segunda opinión, los cuidados de seguimiento y las fuentes de apoyo para alguien que ha sido diagnosticado recientemente con cáncer de seno.


Comienza la construcción de instalación patrocinada por el NCI en Puerto Rico para realizar estudios clínicos sobre el cáncer

El gobierno de Puerto Rico ha destinado $196 millones de dólares para construir un hospital oncológico de 287 000 pies cuadrados en San Juan, que contará con 96 camas. El nuevo hospital es el primero en su clase en la región caribeña y en él se llevarán a cabo tratamientos para el cáncer y estudios clínicos.


Los NIH anuncian el lanzamiento de 3 estudios integrados de medicina de precisión; ALCHEMIST es para pacientes con ciertos tipos de cáncer de pulmón en estadio inicial

Los Estudios sobre la Secuenciación e Identificación de Marcadores para el Mejoramiento de la Terapia Adjuvante para el Cáncer de Pulmón, conocidos con el nombre de ALCHEMIST, identificarán a pacientes con cáncer de pulmón en estadio inicial cuyos tumores albergan ciertos cambios genéticos, y evaluarán si los tratamientos con medicamentos que actúan sobre esos cambios pueden mejorar la supervivencia.



Microsoft Academic Search

con cuatro repeticiones. La unidad experimental net a fue 20m 2 (20mx1m). Las variables evaluadas fueron: Incremento de altura y diámetro, número de brotes, producción de tallos, peso de tallos en verde, determinación de m ateria seca, peso de tallos en blanca, número de días de apertura de flor, número de días en florero y análisis económico. El tratamiento que


CDIGO DIA HORA AULA CURSO TITULACION ASIGNATURA 1003306 13/06/2014 12:00 Ningn Matriculado 1 I.T. Industrial (Qumica Industrial) Expresin Grfica y Diseo Asistido por Ordenador  

E-print Network

.T. Industrial (Química Industrial) Tratamiento de Aguas Residuales 1003324 24/06/2014 15:00 005 Aulario III 3 I.T. Industrial (Química Industrial) Seguridad e Higiene Industriales 1003330 23/06/2014 15:00 002 Aulario I 3 I

Rey Juan Carlos, Universidad


En el ao 1991se creaba el Insti-tuto Universitario del Agua y las  

E-print Network

en el tratamiento de aguas residuales industriales, experien- cias de reutilización de aguas resiEn el año 1991se creaba el Insti- tuto Universitario del Agua y las Ciencias otra denominación, se imparte el máster Gestión Sostenible y Tec- nología del Agua, adaptado al Es

Escolano, Francisco



Microsoft Academic Search

El tratamiento a la niñez y la adolescencia a escala internacional necesitan más que protección jurídica, atención especial de los Estados y en el caso específico de Cuba esta protección está garantizada, siendo prioridad del Estado revolucionario el desarrollo integral y multifacético de nuestros Niños, Niñas y Adolescentes. La protección jurídica que en el caso de Cuba se da a

Xiomara Cabrera Cabrera



Manejo anestésico para la implantación de electrodos epicárdicos en el ventrículo izquierdo, mediante cirugía mínimamente invasiva asistida  

Microsoft Academic Search

Resumen El tratamiento médico de los pacientes con disfunción sistólica del ventrículo izquierdo (VI) y afectos de insufi- ciencia cardiaca congestiva (ICC), ha mejorado su cali- dad de vida pero no así la mortalidad. Existe un sub- grupo de estos pacientes, con alteraciones en la conducción interventricular y asincronía de la contrac- ción ventricular, en los que la terapia de

N. Lafuente; B. Izquierdo; A. Rodríguez; J. Chueca; M. Puértolas; R. Ruiz


Añadir quimioterapia después de la radioterapia mejora la supervivencia de adultos con un tipo de tumor cerebral de crecimiento lento

Adultos con gliomas de grado bajo, una forma de tumor cerebral, que recibieron tratamiento con quimioterapia después de la radioterapia vivieron más tiempo que pacientes que recibieron solo radioterapia, según los resultados de seguimiento a largo plazo de un estudio clínico aleatorizado y controlado, subvencionado por los NIH.


Ma50B Complejidad Computacional Semestre Otono, 2008 Bibliografa  

E-print Network

). Referencias [AB08] S. Arora y B. Bark. Complexity Theory: A Modern Approach Versiâ??on preliminar en httpMa50B Complejidad Computacional Semestre Otoâ?no, 2008 Bibliografâ??�a Profesor: M. Kiwi El texto actualizada es el Arora y Barak [AB08]. Para un tratamiento menos formal y un mayor â??enfasis en la parte algor

Rapaport, Iván


Ma50B Complejidad Computacional Semestre Oto~no, 2008 Bibliografia  

E-print Network

). Referencias [AB08] S. Arora y B. Bark. Complexity Theory: A Modern Approach Versi´on preliminar en httpMa50B Complejidad Computacional Semestre Oto~no, 2008 Bibliograf´ia Profesor: M. Kiwi El texto es el Arora y Barak [AB08]. Para un tratamiento menos formal y un mayor ´enfasis en la parte algor

Rapaport, Iván


Ma50b Complejidad Computacional Semestre Otono, 2009 Bibliografa  

E-print Network

). Referencias [AB08] S. Arora y B. Bark. Complexity Theory: A Modern Approach Versiâ??on preliminar en httpMa50b Complejidad Computacional Semestre Otoâ?no, 2009 Bibliografâ??�a Profesor: M. Kiwi El texto actualizada es el Arora y Barak [AB08]. Para un tratamiento menos formal y un mayor â??enfasis en la parte algor

Rapaport, Iván


Ma50b Complejidad Computacional Semestre Oto~no, 2009 Bibliografia  

E-print Network

). Referencias [AB08] S. Arora y B. Bark. Complexity Theory: A Modern Approach Versi´on preliminar en httpMa50b Complejidad Computacional Semestre Oto~no, 2009 Bibliograf´ia Profesor: M. Kiwi El texto es el Arora y Barak [AB08]. Para un tratamiento menos formal y un mayor ´enfasis en la parte algor

Rapaport, Iván


The French Connection: Cuisine and Water Treatment  

Microsoft Academic Search

During a one-week tour of water treatment plants in France, the author observed several small, simple water systems as well as some of the largest and most sophisticated installations in France. Cultural expectations that affect water treatment practices were of special interest, as were the professional resources provided by privatization. Durante su visita de una semana a plantas de tratamiento

Ida M. Sayre




Microsoft Academic Search

RESUMEN El procesamiento de imágenes es una herramienta común para estudiar proble- mas científicos en muchas áreas diferentes, tales como la imagenología biomédica, televisión, las publicaciones electrónicas, tales como las páginas WEB y la multi- media. Existen muchos sistemas de tratamiento de imágenes en las universidades para la enseñanza a un nivel introductorio y en el nivel de postgrado. Muchos



Terapias adyuvantes y neoadyuvantes para el cáncer de seno

Hoja informativa que explica las terapias adyuvantes (tratamiento que se administra además de la terapia primaria para aumentar la posibilidad de supervivencia a largo plazo) y las neoadyuvantes (terapia que se administra antes de la terapia principal). Contiene información sobre los efectos secundarios y sobre los riesgos y beneficios de estas terapias.


On-Site Wastewater Treatment Systems: Operation and Maintenance (Spanish)  

E-print Network

del sistema de tratamiento de aguas negras porque puede aplastarlos. Los componentes han sido dise?ados para sostener el suelo sobre el sistema, pero no para aguantar que pase equipo sobre ?l. 3 Las aguas negras contienen bacteria natural que...

Lesikar, Bruce J.; Enciso, Juan




Microsoft Academic Search

En Cuba existe una estrategia ambiental dirigida a disminuir el efecto de degradación de los suelos y el cambio climático, implementar de forma generalizada la agricultura sostenible, eliminar las manifestaciones de vertimiento inadecuado de residuos líquidos y sólidos sin un accionar científico que permita su re-uso y tratamiento, controlar la contaminación ambiental, la desertificación de los suelos, la deforestación, la

Armando Paz Aguilera; Tania Lestapier Reyes; Dágmaris Fernández Barbán; Yaritza Milagros La O Soria; Rogelio García Tejera; Rafael Leyva Galán



Dealing with Storm-Damaged Trees (Spanish)  

E-print Network

ER-040S 10-07 Tratamiento de ?rboles da?ados por la tormenta Melanie R. Kirk, Especialista en Programa de Extensi?n Eric L. Taylor, Profesor Adjunto y Especialista de Extensi?n y C. Darwin Foster, Jefa Adjunta del Departamento y L?der del Programa...

Kirk, Melanie; Taylor, Eric; Foster, C. Darwin



ALCHEMIST (Estudios sobre la Secuenciación e Identificación de Marcadores para el Mejoramiento de la Terapia Adjuvante para el Cáncer de Pulmón): Preguntas y respuestas

ALCHEMIST comprende tres estudios clínicos integrados de medicina de precisión diseñados para identificar a personas con cáncer de pulmón en estadio inicial cuyos tumores tienen ciertos cambios genéticos poco comunes. También buscan evaluar si los tratamientos con medicamentos que combaten esos cambios moleculares pueden mejorar la supervivencia


Impacto de las redes sociales de pacientes en la práctica asistencial  

Microsoft Academic Search

Las redes sociales de pacientes son espacios virtuales donde pacientes con condiciones similares se ponen en contacto y comparten tratamientos y problemas de salud. Estas redes ofrecen a las personas con problemas específicos de salud la oportunidad de compartir experiencias, buscar, recibir y proveer información, consejos e incluso apoyo emocional online. Pero, ¿cuál es el impacto de estas redes en

Elena Torrente; Joan Escarrabill; Tino Martí



El análisis de las interacciones grupales: las aplicaciones SOCIOS  

Microsoft Academic Search

El concepto de ‘interacción’ representa uno de los núcleos fundamentales de la Psicología Social. En los grupos y las organizaciones, esto significa focalizar las explicaciones de los fenómenos en el sistema de relaciones de “influenciarecíproca” que se establece entre sus componentes. El análisis de las matrices de interacción requiere la utilización de algoritmos específicos de tratamiento de la información, no

José Manuel Cornejo Álvarez



Drug Facts  

MedlinePLUS Videos and Cool Tools

... this page Hear and read a story about drug treatment. Take a quiz : What do you know about drugs? Haga clic aquí para información sobre el abuso ... y tratamiento. VIDEO: Anyone Can Become Addicted to Drugs VIDEO: Why Are Drugs So Hard to Quit? ...


Etapa final de la vida (PDQ®)

Sumario informativo revisado por expertos sobre el tratamiento y la atención del paciente de cáncer desde los últimos días hasta las últimas horas de vida; esto incluye los síntomas comunes, los dilemas éticos que pueden surgir y la función que desempeña el oncólogo en proveer cuidados al paciente y su familia durante este período.


Los Derechos de los Pacientes del Centro Clnico  

E-print Network

Los Derechos de los Pacientes del Centro Clínico Los Derechos de los Pacientes del Centro Clínico medir las respuestas de los pacientes al tratamiento. Existen procesos que protegen los derechos de paciente que se observen los derechos fundamentales de la dignidad humana. Esta Declaración de Derechos


Iniciativa de Respuestas Excepcionales: Preguntas y respuestas

El Instituto Nacional del Cáncer (NCI) emprendió la Iniciativa de Respuestas Excepcionales (Exceptional Responders Initiative) a fin de entender la base molecular de los tumores en pacientes de cáncer que responden en forma excepcional al tratamiento, principalmente el administrado por quimioterapia.


On-Site Wastewater Treatment Systems: Leaching Chambers (Spanish)  

E-print Network

tratamiento de aguas negras C?maras de percolaci?n Bruce Lesikar, Juan Enciso y Russell Persyn Promotores Especialistas de Ingenier?a Agr?cola, Promotor Adjunto de Conservaci?n del Agua El Sistema Universitario Texas A&M Un sistema de c?mara de percola- ci...

Lesikar, Bruce J.; Enciso, Juan



On-Site Wastewater Treatment Systems: Tablet Chlorination (Spanish)  

E-print Network

L-5344S 01-06 Figura 1: La manera m?s com?n de desinfectar los sistemas individuales es la cloraci?n con pastilla. Sistemas individuales para el tratamiento de aguas negras Cloraci?n con pastilla Richard Weaver, Bruce Lesikar y Juan Enciso Profesor...

Weaver, Richard; Lesikar, Bruce J.; Enciso, Juan



On-Site Wastewater Treatment Systems: Gravel-less Pipe (Spanish)  

E-print Network

tratamiento de aguas negras Tuber?a sin grava Bruce Lesikar, Juan Enciso y Russell Persyn Promotores Especialistas de Ingenier?a Agr?cola, Promotor Adjunto de Conservaci?n de Agua El Sistema Universitario Texas A&M L os sistemas de tuber?a sin grava...

Lesikar, Bruce J.; Enciso, Juan



Medicina de precisión y terapia dirigida

Información sobre la función que desempeñan las terapias dirigidas en la medicina de precisión. Explica cómo las terapias dirigidas actúan contra el cáncer, quién recibe estas terapias, los efectos secundarios más comunes y lo que se debe esperar al recibir este tipo de tratamientos.


Visión Estereo para Posicionamiento de Pacientes en Radioterapia  

Microsoft Academic Search

Resumen— Durante la radioterapia se administran dosis tumoricidas con el fin de eliminar las células cancerosas. Una vez que se ha determinado la\\/las regiones a irradiar, se debe tener especial cuidado en el posicionamiento del paciente en el acelerador lineal y su posterior re-posicionamiento de modo tal que la zona bajo tratamiento sea siempre la misma, minimizando el daño al

Arnulfo Ortiz Torres; Andrés Valdez; Guillermo Alvarez


Nutrient Availability in Rangeland Soils: Influence of Prescribed Burning, Herbaceous Vegetation Removal, Overseeding with Bromus tectorum, Season, and Elevation  

E-print Network

Removal, Overseeding with Bromus tectorum, Season, and Elevation R. R. Blank,1 J. Chambers,2 B. Roundy,3 prescribed burning, herbaceous vegetation removal, and controls. Cheatgrass (Bromus tectorum L´ Bromus tectorum L. en pequen~as subparcelas dentro de cada tratamiento. Posterior a la aplicacio´n de


La tomografía por emisión de positrones (PET\\/CT). Utilidad en oncología  

Microsoft Academic Search

Resumen En oncología es necesario el diagnóstico y estadificación preci- sos del paciente con cáncer, para tener resultados óptimos en su tratamiento. La tomografía por emisión de positrones (PET) tiene alto valor predictivo negativo mediante la exploración del cuerpo entero. Diagnostica la benignidad o malignidad de una neoplasia detectada por otros métodos de imagen; establece el diagnóstico de extensión previo

David Martínez-Villaseñor; Raquel Gerson-Cwilich



Qué tipos hay de estudios clínicos

Información sobre los diversos tipos de estudios clínicos de cáncer, como son los estudios de tratamiento, de prevención, de exámenes selectivos de detección, de cuidados médicos de apoyo y de cuidados paliativos. Cada tipo de estudio está diseñado para responder a diferentes cuestiones de investigación.


Cómo hacer frente al cáncer: cuidados médicos de apoyo y cuidados paliativos

Formas de controlar los efectos físicos y psicológicos del cáncer y del tratamiento en los pacientes y sus familias, así como los efectos en la calidad de vida. También se incluye información sobre servicios de salud, ayuda económica y seguro médico.


1 Introduccin a Spring................................................................................................... 4 1.1 Qu es Spring?....................................................................................................... 4  

E-print Network

validación básica de datos (1 punto)..................................... 61 7 Aplicaciones AJAX y REST con Spring MVC..........................................................63 7.1 AJAX con Spring.............................................................................................. 67 7.3 Tratamiento de errores en aplicaciones AJAX y REST.........................................72

Escolano, Francisco


Mster en Ingeniera Informtica y de Telecomunicacin Horarios, Aulas y Periodos de evaluacin -2011-2012  

E-print Network

Computacional Tecnologías de la Información Avanzadas Sistemas Embebidos y Reconfigurables Tratamiento de MIERCOLES JUEVESLUNES AULA C-105 17-18 18-19 Sistemas colaborativos Neurociencia Computacional I: modelos arquitectura para TDS Neurociencia computacional II: análisis e interpretación de la actividad neuronal

Autonoma de Madrid, Universidad


Mster en Ingeniera Informtica y de Telecomunicacin Horarios, Aulas y Periodos de evaluacin -2010-2011  

E-print Network

Computacional Tecnologías de la Información Avanzadas Sistemas Embebidos y Reconfigurables Tratamiento de evolutiva Neurociencia Computacional I: modelos teóricos y aplicaciones en computación neuronal Simulación y a problemas de predicción Aplicaciones Adaptativas a través de InternetA 1 Neurociencia computacional II

Autonoma de Madrid, Universidad


The Early Geological History of Long Island Sound  

NASA Astrophysics Data System (ADS)

Long Island Sound (LIS), an urban estuary on the east coast of the USA, formed when terminal moraines created Long Island (NY) during the last glaciation. During early deglaciation, a periglacial lake developed behind this moraine (Glacial Lake Connecticut), which was rapidly filled with red, varved lake clays. Glacial Lake Connecticut drained when a barrier at its eastern end towards the Atlantic Ocean failed, at about 18 (calibrated) ka. The LIS basin then dried out, and a fluvial drainage pattern was carved into the lake beds (Lewis and Stone, 1991). With ongoing rise in global sea level, the sea entered LIS from the east and a marine-estuarine sediment sequence was deposited on the partially eroded varved clays. Lake Hitchcock formed behind the rapidly retreating Laurentide ice sheet in eastern New England, drained (possibly catastrophically) around 14 (calibrated) ka (Brigham-Grette, 2001), and created a coarse deltaic structure in LIS. Radiocarbon dates on bulk organic matter from the varved lake clays and marine silts indicate a time frame for Glacial Lake Connecticut between 18 and 16 ka, with the marine transgression possibly occurring around 15 ka (Lewis and DiGiacomo-Cohen, 2000). We dated organic carbon (hand picked terrestrial plant fragments) and mollusk fragments from core samples. Calibrated radiocarbon ages from organic material (ours and existing dates) do not show a clear relationship between age and depth-in-core. Radiocarbon dates show consistently older dates of organic matter than mollusk fragments from the same samples, with differences of up to 3000 years. We infer that the plant remains were stored on land for extensive periods of time before being deposited in LIS. The radiocarbon ages from mollusks show a curvi-linear relationship with depth, and suggest an age of about 10 (calibrated) ka for the marine transgression at the location of core LISAT 12 (in eastern LIS off the coast near Orient Point, Long Island). This new time frame suggests that the marine transgression occurred much later than thought, just after the Younger Dryas cold period and during Melt Water Pulse 1b of Fairbanks et al. (1989). Estimated rates of relative sea level rise from dated oyster beds (about 1.2 cm/yr) agree with the high rates indicated by these authors. This new timing of the flooding of the LIS basin poses the question whether Lake Hitchcock drained into Glacial Lake Connecticut rather than in marine waters. Preliminary stable isotope data on Elphidium excavatum from core LISAT 12 indicate that early LIS may have had slightly lower salinities than modern LIS, but foraminiferal faunas strongly resemble assemblages described from samples dated at 1000-1800 AD.

Varekamp, J. C.; Thomas, E.



Carbon Cycling in Long Island Sound Over the Last 1000 Years  

NASA Astrophysics Data System (ADS)

Long Island Sound is a eutrophied urban estuary that suffers from anoxia during the late summer months. Is the narrow western part of the estuary prone to anoxia as a result of poor circulation during warm periods or is the anthropogenic eutrophication the main driver for the seasonal anoxia? We have reconstructed the history of bottom water oxygenation through the use of stable isotope studies of foraminifera in sediment core samples. The paleo water temperature was approximated from Mg/Ca measurements in shells of the foraminifer Elphidium excavatum and the paleo salinity was calculated from the foram shell's delta 18O values and the temperature estimates. The measured delta 13C values of the shells were corrected for salinity, using our river-seawater mixing model, and the excess delta 13C values were recast into additions of milligrams of algal carbon per liter of water through an isotopic mass balance statement. The equivalent oxygen consumption was then used to calculate the water oxygen contents, which was divided by the saturated oxygen contents of the waters at the calculated temperature and salinity. The resulting percent oxygen saturation values for 5-10 year average values (time in a sediment slice) were plotted as a function of time (cores were dated with a variety of isotopic and pollen techniques). The results show that from 1000 AD to about 1850 AD, mean levels of oxygen saturation were about 70-80 percent; these values started dropping in the mid 19 and 20 century, reaching 30-40 percent saturation values over the last 50 years. The temperature record shows evidence for the warm Mediaeval period, but there is no evidence that the Sound suffered from anoxia at that time. Organic carbon contents of the sediment increased over the last 250 years and organic carbon accumulation rates increased almost 5 fold. Both the amount of sediment-stored organic carbon and the oxidized organic carbon fraction of the total primary productivity increased during the gradual eutrophication of the Sound. We conclude that the main driver of the seasonal anoxia in western Long Island Sound is the release of nutrients (mainly nitrogen compounds) from sewage and run-off, which leads to eutrophication and excess algal carbon production. Modern global warming may provide an additional effect by enhancing water column stratification.

Lugolobi, F.; Varekamp, J. C.; Thomas, E.; Mecray, E.



Bank for International Settlements Communications  

E-print Network

Publicado también en alemán, francés, inglés e italiano. Este Informe puede consultarse en la página del BPI en Internet (Índice Carta de presentación........................................... 1 Resumen de los capítulos económicos........................ 3 I. Más allá del rescate: salir de cuidados intensivos y concluir las reformas............................................ 7 Servicio de urgencias: respuesta inicial a la crisis.......................... 8 Cuidados intensivos: el problema de los efectos secundarios................ 9 Diagnóstico: identificar las causas de la crisis............................. 11 Causas microeconómicas.......................................... 11 Causas macroeconómicas......................................... 12 Solucionar las causas de la crisis........................................ 13 Tratamiento: reducir el riesgo de las exposiciones comunes y de los vínculos..................................................... 14 Reducir el riesgo de quiebras individuales........................... 14 Reducir la probabilidad de un fallo sistémico......................... 17 Tratamiento: reducir la prociclicidad..................................... 20 Reformas: principales áreas pendientes de reforma........................ 21

O Informe Anual; Ch- Basilea Suiza



El Centro para la Salud Mundial del NCI anuncia las primeras becas de investigación para apoyar las tecnologías portátiles

El Centro para la Salud Mundial del NCI (CGH) anunció el otorgamiento de subvenciones que apoyarán el desarrollo y la validación de tecnologías portátiles y de bajo costo. Estas tecnologías tienen el potencial de mejorar la detección temprana, el diagnóstico y los tratamientos no invasivos o mínimamente invasivos de varios tipos de cáncer con una prevalencia particularmente alta en ciertos países con economías de ingreso bajo y mediano.



Microsoft Academic Search

Se propone un tratamiento psiquiÆtrico integral para el conti- nuum psicopatolÛgico conocido como ìEspectro de Trastornos Obsesivo-Compulsivosî (ETOC) que afecta a una gran parte de la poblaciÛn. Este esquema introduce, en la estrategia de los dos tiempos llamada por los psiquiatras ìrelacionadores bimo- dalesî, un tercer tiempo para la reeducaciÛn psicosocial. De allÌ el nombre de ìrelacionadores trimodalesî, que toma



en Fisioterapia del Deporte  

E-print Network

Experto en Fisioterapia del Deporte III Edición RESERVA DE PLAZAY MATRÍCULA Título: Experto en Fisioterapia del Deporte Precio de título: 1.800 Plazo de preinscripción: hasta 15 de Octubre 2014 Nº de: TRATAMIENTO DE LA LESI�N DEPORTIVA EN AGUA BLOQUEV: TERAPIAS MANUALES APLICADAS AL DEPORTE BLOQUEVI: PUNCI�N

Rey Juan Carlos, Universidad


Investigacin Centro de Investigacin y de Estudios Avanzados del Instituto Politcnico Nacional  

E-print Network

Varaldo Biorrefinería de residuales orgánicos: Bioenergías (biohidrógeno, biometano, bioelectricidad) y interés industrial Refugio Rodríguez Vázquez Biorremediación de suelo y agua. Aplicación de residuos persistentes. y aplicación de la nanotecnología en el tratamiento biológico de efluentes industriales. Junio


Instrucciones para el Consentimiento de alguien que no es uno de los  

E-print Network

Instrucciones para el Consentimiento de alguien que no es uno de los padres a tratamiento médico Al final de la línea #1, escriba con letra de molde el nombre del menor. Sólo el nombre de un menor puede una copia a la forma. En las líneas #3 y #4, escriba con letra de molde el nombre completo del padre y


Incomunicación múltiple en el Teatro breve de Solórzano  

E-print Network

FALL 1992 111 Incomunicación múltiple en el Teatro breve de Solórzano Francisco Javier Higuero La mayoría de los estudios críticos centrados en la obra dramática de Carlos Solórzano suelen prestar atención primordialmente al tratamiento teatral..., marionetas, etc. Este teatro ha sido estudiado también muy acertadamente en conexión con la tradición popular y folklórica. Un ejemplo de estas orientaciones de la crítica del teatro de Solórzano podría verse en el libro de Esteban Rivas, Carlos Solórzano...

Higuero, Francisco Javier



Experto Universitario Java Enterprise 2012-2013 Depto. Ciencia de la Computacin e IA  

E-print Network

Experto Universitario Java Enterprise © 2012-2013 Depto. Ciencia de la Computación e IA Lenguaje Java Avanzado Sesión 3: Tratamiento de errores #12;Lenguaje Java Avanzado © 2012-2013 Depto. Ciencia de · Tipos genéricos #12;Lenguaje Java Avanzado © 2012-2013 Depto. Ciencia de la Computación e IA Errores - 3

Escolano, Francisco


Miami: Meca del exilio cubano y escenario medido aunque efervescente  

E-print Network

Agüero, Raúl Duran y David Ferrer, logrando niveles intertextuales muy ricos pues cada movimiento, cada signo básico, cada inflexión verbal, encontró correspondencias afínes en la comunidad cubana del exilio para la que se representó, fuera de que... del autor como Jesús, bajo la dirección de Rolando Moreno, estrenada en 1994. A esta última obra se le dio un tratamiento musical que no desentonó con el tema de la misma y reafirmó el gusto ya estudiado en otra ocasión de esta comunidad por el...

Rizk, Beatriz J.



Latin American Theatre Review, Volume 26, Number 2: Book Reviews  

E-print Network

selección responde plenamente al criterio mencionado, pues se advierte variedad de estilos en las piezas y en lo temático unas plantean el choque cultural y la discriminación padecida por los emigrantes en este país (Martínez y Your Better Half); otras... funcionamiento del estereotipo y de la discriminación racial por parte de la sociedad anglosajona. Frente a este tratamiento se puede ver el orgullo racial y el carácter de rebeldía que la figura del Pachuco (alter ego de Reyna) presenta. Es este personaje...




Impact of estrogen replacement therapy in a male with congenital aromatase deficiency caused by a novel mutation in the CYP19 gene.  


Recent reports of the impact of estrogen receptor alpha and aromatase deficiency have shed new light on the importance of estrogen for bone formation in man. We describe a novel mutation of the CYP19 gene in a 27-yr-old homozygous male of consanguinous parents. A C to A substitution in intron V, at position -3 of the splicing acceptor site before exon VI of the CYP19 gene, is the likely cause of loss of aromatase activity. The mRNA of the patient leads to a frameshift and a premature stop codon 8 nucleotides downstream the end of exon V. Both parents were shown to be heterozygous for the same mutation. Apart from genua valga, kyphoscoliosis, and pectus carniatus, the physical examination was normal including secondary male characteristics with normal testicular size. To substitute for the deficiency, the patient was treated with 50 micro g transdermal estradiol twice weekly for 3 months, followed by 25 micro g twice weekly. After 6 months estrogen levels (<20 at baseline and 45 pg/ml at 6 months; normal range, 10-50) and estrone levels (17 and 34 ng/ml; normal range, 30-85) had normalized. Bone maturation progressed and the initially unfused carpal and phalangeal epiphyses began to close within 3 months and were almost completely closed after 6 months. The bone age, assessed by roentgenographic standards for bone development by Gruelich and Pyle, was 16.5 at baseline and 18-18.5 yr after 6 months of treatment. Bone density of the distal radius (left), assessed by quantitative computed tomography, increased from 52 to 83 mg/cm(3) (normal range, 120-160) and bone mineral density of the lumbar spine, assessed by dual-energy x-ray-absorptiometry, increased from 0.971 to 1.043 g/cm(2) (normal range, >1.150). Osteocalcin as a bone formation parameter increased from 13 to 52 micro g/l (normal range, 24-70) and aminoterminal collagen type I telopeptide as a bone resorption parameter increased from 62.9 to 92.4 nmol/mmol creatinine (normal range, 5-54). Semen analysis revealed oligoazoospermia (17.4 million/ml; normal >20) at baseline. After 3 months of treatment, the sperm count increased (23.1 million/ml) and decreased rapidly (1.1 million/ml) during the following 3 months. The sperm motility was reduced at baseline and decreased further during treatment. Area under the curve of insulin, C-peptide, and blood glucose levels during oral glucose tolerance test decreased after 6 months (insulin: 277 vs. 139 micro U/ml.h; C-peptide 52 vs. 15 ng/m.h; area under the curve glucose: 17316 vs. 12780 mg/d.min). Triglycerides (268 vs. 261 mmol/liter) and total cholesterol levels (176 vs. 198 mmol/liter) did not change significantly, but the low-density lipoprotein/high-density lipoprotein ratio decreased from 5.37 to 3.56 and lipoprotein (a) increased from 19.9 to 60.0 mg/dl (normal range, <30). In this rare incidence of estrogen deficiency, estrogen replacement demonstrated its importance for bone mineralization and maturation and glucose metabolism in a male carrying a novel mutation in the CYP19 gene. PMID:12466340

Herrmann, Burkhard Lorenz; Saller, Bernhard; Janssen, Onno Eilard; Gocke, Peter; Bockisch, Andreas; Sperling, Herbert; Mann, Klaus; Broecker, Martina



The Late Holocene Stratigraphy of an Inlet-Dominated Barrier Island, Pea Island, North Carolina.  

NASA Astrophysics Data System (ADS)

Sedimentological, foraminiferal, geochemical, and geophysical data sets as well as aerial photographs have been used to investigate the natural processes (inlet dynamics, ocean/estuarine washover, and sea-level change) responsible for the late Holocene units preserved in the barrier island subsurface at Pea Island National Wildlife Refuge. Historic nautical charts indicate that three inlets characterized Pea Island between early European exploration (1590) and the late 19th century; aerial photographs show New Inlet open in 1932 and 1940. Vibracores (up to 5.5 m) collected along three transects across Pea Island extend our knowledge of the geological evolution of this region to pre-historic times. The section in the longest core (PI01S6) consists of four fining-upwards depositional sequences. The basal unit of each sequence is a bedded, medium to fine, clean quartz sand with increasing concentrations of organic matter (3-4 % detrital and 5-7 % in situ Spartina alterniflora roots) or irregular mud clasts (2-5 cm) to spherical mud balls (1-2 cm) up core. The clean sand units have so far proven to be barren of foraminifera except for a shelly unit at ca. 220 cm below MSL. The foraminiferal assemblage in this unit is of open shelf character (Elphidium excavatum, Hanzawaia strattoni, and Buccella inusitata). A 14C age on a disarticulated Chione cancellata valve from this unit is cal. 930+/-60 BP. The sand grades into a gray, tight mud in the first two sequences and into an inter-laminated mud and in situ peat in the third sequence. The peat contains leaf fragments and rhizomes of the marsh plants Juncus roemarianus, Spartina cynosuroides, and/or Phragmites spp. The peat and muddy sand units contain marsh foraminifera (Trochammina spp., Miliammina fusca, Arenoparrella mexicana), which are also found in modern marsh deposits. A peat sample from the third fining upward sequence (the only one to grade into a true peat) has a 14C age of cal. 395+/-35 BP, cal. 295+/-35 BP, or cal 180+/-40 BP. The four fining-upwards sequences have sharp erosional basal contacts. These deposits appear to reflect back-barrier processes including sequential deposition of flood-tide delta sands and/or sound sands adjacent to marshes. The shelly sands, containing open shelf foraminiferal assemblages, represent oceanic overwash, inlet deposits, or open embayment sands deposited behind a laterally extensive breach in the barrier island. The sequences are capped by the deposits of modern environments that include algal flats, tidal creeks, high and low marshes, back-barrier berms, overwash fans, and aeolian dunes. Several of the modern environments became covered with marsh vegetation after the construction of barrier dune ridges in the late 1930?s.

Smith, C. G.; Ames, D.; Corbett, D. R.; Culver, S.; Mallinson, D.; Riggs, S. R.; Vance, D.



Controlling the Pecan Nut Casebearer (Spanish)  

E-print Network

confiable es realizar una, o varias, apli- caciones oportunas de insecticida en la primavera para eliminar a las larvas en eclosi?n antes de que ?stas penetren las nuececillas. Sin embargo, los insecticidas deben aplicarse ?nicamente cuando el nivel de...?n del insecticida debe calcu- larse con exactitud para controlar las larvas reci?n eclo- sionadas del barrenador de la nuez antes de que ?stas penetren las nueces. Una vez dentro, las larvas est?n protegidas de los tratamientos con insecticida. En la...

Knutson, Allen E.; Ree, Bill



Flea Control (Spanish)  

E-print Network

aerosol, champ?, y collares para las mas- cotas. Si su mascota ya tiene una infestaci?n aguda, se debe usar una combinaci?n de regulador de crec- imiento y un insecticida aerosol. Evite el uso de aerosoles t?xicos directamente sobre la mascota... la misma vez que trate las ?reas donde habita (adentro y afuera) la mascota. Tratamiento de la mascota ? S?lo use productos que indiquen que son para las mascotas en su etiqueta. Insecticidas para los per- ros pueden ser peligrosos a los gatos, as...

Merchant, Michael E.



Part 9, Authors: L To Lyutkevich  

E-print Network

Naturwissenschaftlichen Ver- eins zu Magdeburg. Magdeburg. Kat. Pal?arkt. Dipt.?Katalog der Paia ark-tischen Dipteren. Bearbeitet von Th. Becker, Dr. M. Bezzi, Dr. K. Kertesz und P. Stein. Budapest. Kort. M. J. [Not available] Landwirthsch. Ann. Mecklenb. Patriot. Ver.... [W?.] L., H. [Dr., Mannheim] 1931 a.?Neuer Parasit au Daphnien im Aquarium beobachtet Tratamiento de los oxiuros en el adulto

Segal, Dorothy B.; Ray, Doris H.; Hassall, Albert; Doss, Mildred A.



Teatro en Santiago de Chile: Temporada 1981  

E-print Network

—Susana Cumsille y Carlos Zaror—montaron en Galpón de los Leones, Dos viejos pânicos de Virgilio Pinera, dirigida por Exequiel Lavandero. El grupo Teatro Abierto formado por Sonia Mena y Sergio Aguirre, a los que agregan Jean Mazoyer y Eduardo Barril... concesiones a su público. El tratamiento del tema se universaliza, aunque los marginados de Chile estén allí representados, mejor que en ninguna otra obra de 1981. Tejado de vidrio, cuya "acción se desarrolla en un día del año 1972," explora un tema hasta...

Bravo-Elizondo, Pedro



Información sobre el cáncer para hispanos y latinos

Cada vez más estadounidenses sobreviven al cáncer y continúan llevando vidas productivas. Sin embargo, muchos hispanos y latinos en los Estados Unidos no han escuchado este mensaje, y no se han beneficiado de los adelantos en los campos de la detección temprana y el tratamiento. El nuevo sitio web del Instituto Nacional del Cáncer,, lanzado el día 2 de abril de 2007, comunica enérgicamente el mensaje de que el cáncer puede prevenirse y tratarse, y ofrece, además, información sobre todos los aspectos de la enfermedad.


Late Differentiation Syndrome in Acute Promyelocytic Leukemia: A Challenging Diagnosis  

PubMed Central

Detailed knowledge about differentiation syndrome (DS) has remained limited. There are 2 large studies conducted by the Spanish workgroup PETHEMA (Programa Español de Tratamientos en Hematología; Spanish Program on Hematology Treatments) and the European group trial (LPA 96-99 and APL 93) in which the incidence, characteristics, prognostic factors and outcome of patients developing DS are evaluated. Both have described the median time of DS development between 10 and 12 days. The severity of the DS has been evaluated in the study conducted by PETHEMA, and severe DS usually occurs at the beginning of the treatment (median of 6 days), as compared with moderate DS (median of 15 days). We report here in two cases of late severe DS, with late diagnosis due to both time and form of presentation. We discuss the physiopathology, clinical presentation, prophylaxis and treatment of DS. PMID:25568763

Cabral, Renata; Caballero, Juan Carlos; Alonso, Sara; Dávila, Julio; Cabrero, Monica; Caballero, Dolores; Vázquez, Lourdes; Sánchez-Guijo, Fermin; López, Lucia; Cañizo, Maria C.; Mateos, Maria V.; González, Marcos




PubMed Central

Introduccion La diabetes mellitus y las demencias constituyen dos problemas crecientes de salud entre la población adulta mayor del mundo y en particular de los paises en desarrollo. Hacen falta estudios longitudinales sobre el papel de la diabetes como factor de riesgo para demencia. Objetivo Determinar el riesgo de demencia en sujetos Mexicanos con diabetes mellitus tipo 2. Materiales y Metodos Los sujetos diabéticos libres de demencia pertenecientes al Estudio Nacional de Salud y Envejecimiento en México fueron evaluados a los dos años de la línea de base. Se estudió el papel de los factores sociodemográficos, de otras comorbilidades y del tipo de tratamiento en la conversión a demencia. Resultados Durante la línea de base 749 sujetos (13.8%) tuvieron diabetes. El riesgo de desarrollar demencia en estos individuos fue el doble (RR, 2.08 IC 95%, 1.59–2.73). Se encontró un riesgo mayor en individuos de 80 años y más (RR 2.44 IC 95%, 1.46–4.08), en los hombres (RR, 2.25 IC 95%, 1.46–3.49) y en sujetos con nivel educativo menor de 7 años. El estar bajo tratamiento con insulina incrementó el riesgo de demencia (RR, 2.83, IC 95%, 1.58–5.06). Las otras comorbilidades que aumentaron el riesgo de demencia en los pacientes diabéticos fueron la hipertensión (RR, 2.75, IC 95%, 1.86–4.06) y la depresión (RR, 3.78, 95% IC 2.37–6.04). Conclusión Los sujetos con diabetes mellitus tienen un riesgo mayor de desarrollar demencia, La baja escolaridad y otras comorbilidades altamente prevalentes en la población Mexicana contribuyen a la asociación diabetes-demencia. PMID:21948010

Silvia, Mejía-Arango; Clemente, y Zúñiga-Gil



Grupos españoles de cálculos ab initio de moléculas de interés astrofísico  

NASA Astrophysics Data System (ADS)

Pocos campos de la química están tan bien adaptados a la modelización por medio de los métodos teóricos de la Química Cuántica como la Astroquímica y la Química de la Atmósfera, donde las interacciones moleculares son, generalmente, lo suficientemente pequeñas para que el modelo de molécula aislada funcione muy bien. En España son varios los grupos teóricos que dedican su esfuerzo de investigación, o parte de él, al estudio de moléculas o procesos de interés en Astrofísica o en atmósferas planetarias. Presentaremos diferentes ejemplos paradigmáticos de esta actividad en la que se exploran desde aspectos estructurales, hasta aspectos espectroscópicos y dinámicos. Entre los últimos, cabe destacar estudios en los que se demuestra la importancia de procesos a dos estados, prohibidos por espín, en la formación astrofísica de diversos derivados de interés. En el tratamiento espectroscópico se han hecho esfuerzos interesantes, que han aunado teoría y experimento, en el estudio de sistemas relevantes desde el punto de vista atmosférico, como los hidratos de ácido nítrico, o el tratamiento espectroscópico de moléculas no rígidas. No menos interesantes son los estudios de fotoabsorción de radicales o de procesos multifotónicos. Son particularmente abundantes los estudios dedicados a la reactividad específica de sistemas de interés astrofísico o atmosférico, con el objetivo de esclarecer vías de formación de determinados compuestos o de proporcionar mecanismos que permitan identificar las etapas reactivas limitantes de reacciones de interés en esos medios y sobre los que no existía información previa. Así, por ejemplo, se han publicado interesantes estudios sobre la formación o propiedades de compuestos de fósforo, de silico o de azufre o sobre mecanismos de reacción en los que intervienen el ozono, el radical nitrato, el radical OH u otras especies. Finalmente, son también particularmente relevantes los estudios que varios grupos españoles han llevado, y siguen llevando a cabo, sobre sistemas débilmente enlazados, como complejos de Van der Waals o complejos por enlace de hidrógeno, que sin duda juegan un papel importante tanto en medios atmosféricos como interestelares.

Yáñez, M.


The residual and direct effects of reduced-risk and conventional miticides on twospotted spider mites, Tetranychus urticae (Acari: Tetranychidae) and predatory mites (Acari: Phytoseiidae)  

SciTech Connect

The residual effects of several reduced-risk and conventional miticides were evaluated in strawberries (Fragaria z ananassa Duchesne) on the twospotted spider mite (TSSM), Tetranychus urticae Koch (Acari: Tetranychidae) and on 2 predatory mites, Neoseiulus californicus McGregor and Phytoseiulus persimilis Athias-Henriot (Acari: Phytoseiidae). Experiments were conducted in the laboratory and greenhouse. The greenhouse experiments also tested the direct effects of the miticides on TSSM. The efficacy of conventional and reduced-risk miticides was evaluated on strawberry leaf discs and on whole plants for control of TSSM. Furthermore, the residual effects of these miticides were evaluated on whole strawberry plants against selective predatory mites. For TSSM, 5 treatments were evaluated: a conventional miticide; fenbutatin-oxide (Vendex[reg]) and 3 reduced-risk miticides; binfenazate (Acramite 50WP[reg]), activated garlic extract (Repel[reg]), sesame seed and castor oil (Wipeout[reg]), and a water-treated control. For predatory mites, the residual effects of only Acramite[reg] and Vendex[reg] were evaluated. Acramite[reg] was the most effective acaricide in reducing TSSM populations in both the laboratory and greenhouse experiments. Vendex[reg] and Wipeout[reg] were also effective in the laboratory, but did not cause significant reduction of TSSM in the greenhouse. Repel[reg] was the least effective of the 4 pesticides evaluated. Neither Acramite[reg] nor Vendex[reg] had a significant effect on either predatory mite species. However, there appeared to be more predatory mites on the Vendex[reg]-treated plants than on the Acramite[reg]-treated plants. There were significantly more predatory mites of both species on the cue plants, which were inoculated with TSSM versus the non-cue plants, which were not inoculated. (author) [Spanish] Los efectos residuales en poblaciones de la 'arana roja', Tetranychus urticae Koch (Acari: Tetranichidae) y de los acaros predadores Neoseiulus californicus McGregor y Phytoseilus persimilis Athias-Henriot (Acari: Phytoseiidae) causados por varios acaricidas convencionales y de riesgo-reducido fueron evaluados en fresas (Fragaria x ananassa Duchense). Los experimentos fueron realizados en laboratorio e invernadero. Los experimentos en el invernadero evaluaron tambien el efecto directo de los acaricidas en la 'arana roja'. La eficacia para controlar la 'arana roja' de los acaricidas convencionales y de riesgo-reducido fue evaluada en discos de las hojas y en plantas de fresa, y los efectos residuales de los acaricidas en los acaros predadores fueron evaluados en plantas completas. Para la 'arana roja' se evaluaron cinco tratamientos: el acaricida convencional fenbutatin-oxido (Vendex[reg]), 3 acaricidas de riesgo-reducido binfenazate (Acaramite 50WP[reg]), extracto de ajo activado (Repel[reg]), aceite de semillas de ajonjoli y ricino (Wipeout[reg]) y un control tratado con agua. Para los acaros predadores solamente los efectos de Acaramite[reg] y Vendex[reg] fueron evaluados. Acaramite[reg] fue el tratamiento mas efectivo para la 'arana roja' en el laboratorio y el invernadero. Vendex[reg] y Wipeout[reg] fueron tambien efectivos en el laboratorio, pero no causaron una reduccion significativa de 'aranas rojas' en el invernadero. Repel[reg] fue el tratamiento evaluado menos eficaz. Ni Acaramite[reg] ni Vendex[reg] redujeron significativamente las poblaciones de acaros predadores. Sin embargo, aparentemente hay mas acaros predadores en Vendex[reg] que en Acaramite[reg]. Tambien se encontraron significativamente mas acaros predadores en plantas inoculadas que en plantas no inoculadas. (author)

Liburd, O.E.; White, J.C.; Rhodes, E.M. [Department of Entomology and Nematology, University of Florida, Gainesville, FL 32611 (United States); Browdy, A.A. [Department of Food Science and Human Nutrition, University of Florida, Gainesville, FL 32611 (United States)



Cirugía transnasal endoscópica para tumores de hipófisis  

PubMed Central

Introducción: Exponer la técnica utilizada y los resultados obtenidos en los primeros 52 pacientes portadores de tumores hipofisarios tratados por la vía endoscópica transnasal en el Hospital Italiano de Buenos Aires Métodos: Se llevó a cabo un análisis retrospectivo de 52 cirugías endoscópicas transnasales utilizadas en el tratamiento de tumores hipofisários. Las mismas fueron realizadas en el Hospital Italiano de Buenos Aires durante el período junio del 2011 a junio del 2012. Se analizaron las características demográficas de los pacientes, la patología de base y la morbimortalidad asociada a la cirugía. Resultados: La edad media de los pacientes fue de 41,52 años con un rango de 18-79. La distribución fue similar entre hombres y mujeres. Las patologías más frecuentes fueron: adenomas no funcionantes (40.4%), tumores productores de GH/Acromegalia (25%) y tumores productores de ACTH/Enfermedad de Cushing (23.1%). Aproximadamente el 70 % correspondieron a macroadenomas. Sólo un paciente presentó complicaciones. No se registro ningún óbito. Conclusión: Si bien podremos objetivar fehacientemente resultados más concluyentes en futuros trabajos, podemos decir a priori que, en la endoscopía el detalle anatómico es claramente superior al microscópico y que la posibilidad de la introducción del endoscopio en la silla turca permite la visualización directa de remanentes tumorales, de sitios de fístula y como así también de la glándula normal, ventajas que potencialmente podrían permitir obtener mejores resultados quirúrgicos, en términos de control de la enfermedad y tasa de complicaciones. PMID:23596553

Ajler, Pablo; Hem, Santiago; Goldschmidt, Ezequiel; Landriel, Federico; Campero, Alvaro; Yampolsky, Claudio; Carrizo, Antonio



Smoldering multiple myeloma requiring treatment: time for a new definition?  

PubMed Central

Smoldering multiple myeloma (SMM) bridges the gap between monoclonal gammopathy of undetermined significance (a mostly premalignant disorder) and active multiple myeloma (MM). Until recently, no interventional study in patients with SMM showed improved overall survival (OS) with therapy as compared with observation. A report from the PETHEMA-GEM (Programa Español de Tratamientos en Hematologica) group described both fewer myeloma-related events and better OS among patients with high-risk SMM who were treated with lenalidomide and dexamethasone. This unique study prompted us to review current knowledge about SMM and address the following questions: (1) Are there patients currently defined as SMM who should be treated routinely? (2) Should the definitions of SMM and MM be reconsidered? (3) Has the time come when not treating is more dangerous than treating? (4) Could unintended medical harm result from overzealous intervention? Our conclusion is that those patients with the highest-risk SMM (extreme bone marrow plasmacytosis, extremely abnormal serum immunoglobulin free light chain ratio, and multiple bone lesions detected only by modern imaging) should be reclassified as active MM so that they can receive MM-appropriate therapy and the paradigm of careful observation for patients with SMM can be preserved. PMID:24144641

Stewart, A. Keith; Chanan-Khan, Asher; Rajkumar, S. Vincent; Kyle, Robert A.; Fonseca, Rafael; Kapoor, Prashant; Bergsagel, P. Leif; McCurdy, Arleigh; Gertz, Morie A.; Lacy, Martha Q.; Lust, John A.; Russell, Stephen J.; Zeldenrust, Steven R.; Reeder, Craig; Roy, Vivek; Buadi, Francis; Dingli, David; Hayman, Suzanne R.; Leung, Nelson; Lin, Yi; Mikhael, Joseph; Kumar, Shaji K.



Smoldering multiple myeloma requiring treatment: time for a new definition?  


Smoldering multiple myeloma (SMM) bridges the gap between monoclonal gammopathy of undetermined significance (a mostly premalignant disorder) and active multiple myeloma (MM). Until recently, no interventional study in patients with SMM showed improved overall survival (OS) with therapy as compared with observation. A report from the PETHEMA-GEM (Programa Español de Tratamientos en Hematologica) group described both fewer myeloma-related events and better OS among patients with high-risk SMM who were treated with lenalidomide and dexamethasone. This unique study prompted us to review current knowledge about SMM and address the following questions: (1) Are there patients currently defined as SMM who should be treated routinely? (2) Should the definitions of SMM and MM be reconsidered? (3) Has the time come when not treating is more dangerous than treating? (4) Could unintended medical harm result from overzealous intervention? Our conclusion is that those patients with the highest-risk SMM (extreme bone marrow plasmacytosis, extremely abnormal serum immunoglobulin free light chain ratio, and multiple bone lesions detected only by modern imaging) should be reclassified as active MM so that they can receive MM-appropriate therapy and the paradigm of careful observation for patients with SMM can be preserved. PMID:24144641

Dispenzieri, Angela; Stewart, A Keith; Chanan-Khan, Asher; Rajkumar, S Vincent; Kyle, Robert A; Fonseca, Rafael; Kapoor, Prashant; Bergsagel, P Leif; McCurdy, Arleigh; Gertz, Morie A; Lacy, Martha Q; Lust, John A; Russell, Stephen J; Zeldenrust, Steven R; Reeder, Craig; Roy, Vivek; Buadi, Francis; Dingli, David; Hayman, Suzanne R; Leung, Nelson; Lin, Yi; Mikhael, Joseph; Kumar, Shaji K



Promoting cultural humility during labor and birth: putting theory into action during PRONTO obstetric and neonatal emergency training.  


Maternal and neonatal mortality in Northern Guatemala, a region with a high percentage of indigenous people, is disproportionately high. Initiatives to improve quality of care at local health facilities equipped for births, and increasing the number of births attended at these facilities will help address this problem. PRONTO (Programa de Rescate Obstétrico y Neonatal: Tratamiento Óptimo y Oportuno) is a low-tech, high-fidelity, simulation-based, provider-to-provider training in the management of obstetric and neonatal emergencies. This program has been successfully tested and implemented in Mexico. PRONTO will now be implemented in Guatemala as part of an initiative to decrease maternal and perinatal mortality. Guatemalan health authorities have requested that the training include training on cultural humility and humanized birth. This article describes the process of curricular adaptation to satisfy this request. The PRONTO team adapted the existing program through 4 steps: (a) analysis of the problem and context through a review of qualitative data and stakeholder interviews, (b) literature review and adoption of a theoretical framework regarding cultural humility and adult learning, (c) adaptation of the curriculum and design of new activities and simulations, and (d) implementation of adapted and expanded curriculum and further refinement in response to participant response. PMID:23360940

Fahey, Jenifer O; Cohen, Susanna R; Holme, Francesca; Buttrick, Elizabeth S; Dettinger, Julia C; Kestler, Edgar; Walker, Dilys M



Esquizofrenia y trastorno en el consumo de sustancias: prevalencia y characterísticas sociodemográficas en la población Latina  

PubMed Central

El interés por comprender la co-morbilidad de la esquizofrenia y el trastorno en el uso de sustancias, ha aumentado debido al incremento de este diagnóstico, a los efectos negativos observados en el sujeto y a los costos en los servicios de salud. Este trastorno dual puede tener efectos dramáticos en el curso clínico del trastorno psicótico tales como: mayores recaídas, re-hospitalizaciones, síntomas más severos, no adherencia al tratamiento antipsicótico, cambios marcados del humor, aumento en el grado de hostilidad e ideación suicida, así como alteraciones en otras áreas del funcionamiento incluyendo violencia, victimización, indigencia y problemas legales. La literatura proveniente en particular de Estados Unidos y Europa sugiere que el rango de prevalencia para este diagnóstico puede oscilar entre el 10% hasta el 70%. En este estudio, revisamos la prevalencia del diagnóstico dual de esquizofrenia y trastorno en el uso sustancias, así como sus características sociodemográficas, con base en la literatura disponible alrededor del mundo dando énfasis en la poblacion latina. A pesar de que este diagnóstico es ampliamente aceptado, se conoce poco sobre su prevalencia en la población latina, sobre los factores ambientales, demográficos, clínicos y otras características de estos individuos. Un mejor conocimiento sobre este diagnóstico permitiría mejorar los métodos para la detección y adecuada valoración del trastorno en el uso de sustancias en personas con trastornos metales severos como la esquizofrenia. PMID:21404151

Jiménez-Castro, Lorena; Raventós-Vorst, Henriette; Escamilla, Michael



Lessons from scaling up a depression treatment program in primary care in Chile.  


In Chile, the National Depression Detection and Treatment Program (Programa Nacional de Diagnóstico y Tratamiento de la Depresión, PNDTD) in primary care is a rare example of an evidence-based mental health program that was scaled up to the national level in a low- or middle-income country. This retrospective qualitative study aimed to better understand how policymakers made the decision to scale up mental health services to the national level, and to explore the elements, contexts, and processes that facilitated the decision to implement and sustain PNDTD. In-depth semistructured interviews with six key informants selected through intentional sampling were conducted in August-December 2008. Interviewees were senior officers at the Ministry of Health who were directly involved in the decision to scale up the program. Results yielded four elements pivotal to the decisionmaking process: scientific evidence, teamwork and leadership, strategic alliances, and program institutionalization. Each element contributed to building consensus, securing funding, attracting resources, and gaining lasting support from policymakers. Additionally, a review of available documentation led the authors to consider sociopolitical context and use of the media to be important factors. While research evidence for the effectiveness of mental health services in the primary care setting continues to accumulate, low- and middle-income countries should get started on the lengthy process of scaling up by incorporating the elements that led to decisionmaking and implementation of the PNDTD in Chile. PMID:23183564

Araya, Ricardo; Alvarado, Rubén; Sepúlveda, Rodrigo; Rojas, Graciela




PubMed Central

RESUMEN El estigma relacionado al VIH/SIDA continúa afectando la prestación de servicios de salud y el bienestar físico y mental de las personas con VIH/SIDA (PVS). Recientemente la literatura científica ha señalado la importancia de comprender las manifestaciones de estigma más allá de las interacciones individuales. Por tal razón, investigaciones recientes en y fuera de Puerto Rico enfatizan la importancia de entender cómo factores socio-estructurales (FSE) influyen en los procesos de estigmatización social. Con el propósito de examinar los FSE que influyen en las manifestaciones de estigma relacionado al VIH/SIDA, realizamos y analizamos nueve grupos focales compuestos por hombres y mujeres en tratamiento para el VIH/SIDA que habían tenido experiencias estigmatizantes. Los participantes identificaron FSE relacionados a las manifestaciones de estigma, tales como el uso de viviendas especializadas, descentralización de los servicios de salud y el desarrollo de protocolos administrativos excluyentes en los servicios de salud. Los resultados demuestran la importancia de considerar los FSE en el desarrollo e implementación de intervenciones dirigidas a la población. PMID:24639599





PubMed Central

El objetivo del trabajo es conocer las disyuntivas entre los principios de beneficencia y autonomía, que se presentan en la relación médico-paciente, durante la terapéutica del intento de suicidio. La investigación se realizó en dos hospitales psiquiátricos de la Ciudad de México. La muestra incluyó a tres sujetos con intento de suicidio, mayores de 18 años, que eran atendidos en consulta externa a causa de una lesión autoinfligida en el último año, y a tres psiquiatras que trataban a estos pacientes. La información se obtuvo previo consentimiento informado en entrevistas individuales. Se llevó a cabo un análisis de discurso argumentado para encontrar los significados que los participantes otorgaron a los principios bioéticos y las posibles disyuntivas entre éstos. Las discordancias entre la beneficencia y la autonomía estuvieron relacionadas con el beneficio del tratamiento, el respeto por los valores y las creencias de los pacientes, entre otros. Este trabajo presenta consideraciones éticas relevantes en el escenario clínico, al ofrecer al psiquiatra un análisis bioético que le permita actuar de acuerdo con la beneficencia y respetando la autonomía del paciente frente a casos de intento de suicidio y, de esta forma procurar una mejor atención para ellos. PMID:20830214

Mondragón, Liliana; Monroy, Zuraya; Ito, Ma. Emily; Medina-Mora, Dra. Ma. Elena



Life Course Experiences, Pain and Suffering: A Case Study of an Older Mexican American Woman with Mobility Impairment  

PubMed Central

There is a dearth of literature examining how adversity shapes the experiences of pain and/or suffering in a middle aged Mexican American women. The purpose of this qualitative descriptive study was to understand pain and suffering from a life course perspective as described by a Mexican American woman aging with early onset mobility impairment. This Hispanic woman experienced episodes of abuse and rejection over the life course, which may have significantly influenced her pain and suffering experience in adulthood. This adds to the literature on how adversity influences later life pain experience and provides insight on why pharmacological treatment alone may not be as successful as a holistic intervention. Hay escasez de literatura que examine cómo la adversidad da forma a las experiencias de dolor y / o sufrimiento en mujeres mexicana-americana mayores de edad. El propósito de este estudio descriptivo cualitativo fue comprender el dolor y el sufrimiento desde una perspectiva de ciclo de vida como descrito por una mujer mexicana-americana envejeciendo con inicio temprano de deterioro de movilidad. Esta Latina experimentó episodios de maltrato y rechazo, que se percibió haber afectado su experiencia de dolor y sufrimiento luego como adulta. Este estudio aumenta la literatura sobre cómo la adversidad influya la experiencia de dolor más tarde en la vida, y nos permite comprender mejor como el tratamiento farmacológico por sí solo no es tan exitoso como pueda ser una intervención integral. PMID:24830728

Walker, Janiece L.; Harrison, Tracie C.; Hendrickson, Sherry G.



Estrategia innovadora enfocada en parejas del mismo sexo para disminuir la infección del VIH en hombres Latinos  

PubMed Central

Resumen El VIH es un problema de salud importante dentro de la comunidad latina de los Estados Unidos. Gracias a los esfuerzos de prevención, los niveles de contagio entre los latinos se han mantenido estables por más de una década. Sin embargo, esta población sigue siendo afectada a niveles muy altos, en particular entre hombres que tienen sexo con hombres (HSH), de origen latino y que hablan principalmente el idioma español. Existen varios factores que contribuyen a la transmisión del VIH entre esta población, como son: el uso de drogas; la violencia dentro de la pareja; la presencia de infecciones de transmisión sexual; relaciones sexuales sin protección, dentro y fuera de la pareja; el evadir la búsqueda de recursos (prueba y tratamiento adecuado) por temor a ser discriminado o por su estatus migratorio; la escasez de recursos económicos o estado de pobreza y los patrones relacionados a la migración. En particular, Investigaciones Epidemiológicas de Comportamientos han determinado: cómo algunas dinámicas en parejas están directamente asociadas a los comportamientos sexuales de riesgos. En consecuencia, es necesaria mayor investigación para identificar esas dinámicas, y a su vez, realizar intervenciones dirigidas a la reducción de conductas de riesgo enfocadas en parejas de hombres del mismo sexo. En este escrito, se describe la importancia del uso de las relaciones de pareja como estrategia en la reducción de la trasmisión del VIH/SIDA en HSH de origen latino y que hablan principalmente el idioma español en los Estados Unidos.

Martinez, Omar; Wu, Elwin; Sandfort, Theo; Shultz, Andrew Z.; Capote, Jonathan; Chávez, Silvia; Moya, Eva; Dodge, Brian; Morales, Gabriel; Porras, Antonio; Ovejero, Hugo



Prognostic value of FLT3 mutations in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycline monochemotherapy  

PubMed Central

Background Fms-like tyrosine kinase-3 (FLT3) gene mutations are frequent in acute promyelocytic leukemia but their prognostic value is not well established. Design and Methods We evaluated FLT3-internal tandem duplication and FLT3-D835 mutations in patients treated with all-trans retinoic acid and anthracycline-based chemotherapy enrolled in two subsequent trials of the Programa de Estudio y Tratamiento de las Hemopatías Malignas (PETHEMA) and Hemato-Oncologie voor Volwassenen Nederland (HOVON) groups between 1996 and 2005. Results FLT3-internal tandem duplication and FLT3-D835 mutation status was available for 306 (41%) and 213 (29%) patients, respectively. Sixty-eight (22%) and 20 (9%) patients had internal tandem duplication and D835 mutations, respectively. Internal tandem duplication was correlated with higher white blood cell and blast counts, lactate dehydrogenase, relapse-risk score, fever, hemorrhage, coagulopathy, BCR3 isoform, M3 variant subtype, and expression of CD2, CD34, human leukocyte antigen-DR, and CD11b surface antigens. The FLT3-D835 mutation was not significantly associated with any clinical or biological characteristic. Univariate analysis showed higher relapse and lower survival rates in patients with a FLT3-internal tandem duplication, while no impact was observed in relation to FLT3-D835. The prognostic value of the FLT3-internal tandem duplication was not retained in the multivariate analysis. Conclusions FLT3-internal tandem duplication mutations are associated with several hematologic features in acute promyelocytic leukemia, in particular with high white blood cell counts, but we were unable to demonstrate an independent prognostic value in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycline-based regimens. PMID:21685470

Barragán, Eva; Montesinos, Pau; Camos, Mireia; González, Marcos; Calasanz, Maria J.; Román-Gómez, José; Gómez-Casares, Maria T.; Ayala, Rosa; López, Javier; Fuster, Óscar; Colomer, Dolors; Chillón, Carmen; Larrayoz, María J.; Sánchez-Godoy, Pedro; González-Campos, José; Manso, Félix; Amador, Maria L.; Vellenga, Edo; Lowenberg, Bob; Sanz, Miguel A.



Team training in obstetric and neonatal emergencies using highly realistic simulation in Mexico: impact on process indicators.  


BackgroundIneffective management of obstetric emergencies contributes significantly to maternal and neonatal morbidity and mortality in Mexico. PRONTO (Programa de Rescate Obstétrico y Neonatal: Tratamiento Óptimo y Oportuno) is a highly-realistic, low-tech simulation-based obstetric and neonatal emergency training program. A pair-matched hospital-based controlled implementation trial was undertaken in three states in Mexico, with pre/post measurement of process indicators at intervention hospitals. This report assesses the impact of PRONTO simulation training on process indicators from the pre/post study design for process indicators.MethodsData was collected in twelve intervention facilities on process indicators, including pre/post changes in knowledge and self-efficacy of obstetric emergencies and neonatal resuscitation, achievement of strategic planning goals established during training and changes in teamwork scores. Authors performed a longitudinal fixed-effects linear regression model to estimate changes in knowledge and self-efficacy and logistic regression to assess goal achievement.ResultsA total of 450 professionals in interprofessional teams were trained. Significant increases in knowledge and self-efficacy were noted for both physicians and nurses (p <0.001- 0.009) in all domains. Teamwork scores improved and were maintained over a three month period. A mean of 58.8% strategic planning goals per team in each hospital were achieved. There was no association between high goal achievement and knowledge, self-efficacy, proportion of doctors or nurses in training, state, or teamwork score.ConclusionsThese results suggest that PRONTO¿s highly realistic, locally appropriate simulation and team training in maternal and neonatal emergency care may be a promising avenue for optimizing emergency response and improving quality of facility-based obstetric and neonatal care in resource-limited settings.Trial registration NCT01477554. PMID:25409895

Walker, Dilys; Cohen, Susanna; Fritz, Jimena; Olvera, Marisela; Lamadrid-Figueroa, Hector; Cowan, Jessica; Hernandez, Dolores; Dettinger, Julia C; Fahey, Jenifer O



Comparison of longevity between a laboratory strain and a natural population of Anastrepha Fraterculus (Diptera: Tephritidae) under field cage conditions  

SciTech Connect

The South American fruit fly Anastrepha fraterculus (Wiedemann) is one of the most destructive fruit pests in this region, infesting major fruit crops. Implementation of the sterile insect technique (SIT) as part of an area-wide integrated approach against this species requires information on the survival of mass-reared and sterilized insects in the field and their ability to mate with wild females. The survival rates in field cages of both non-irradiated and irradiated laboratory flies were compared with that of wild flies. Both types of laboratory flies survived longer than their wild counterparts over the 8 days under the experimental conditions. The irradiation dose (70 Gy) did not affect survival of the laboratory reared flies. Our results improve the prospect of integrating the SIT into the control of A. fraterculus populations in Argentina. (author) [Spanish] Anastrepha fraterculus (Wiedemann), la mosca sudamericana de la fruta, es una de las plagas mas destructivas en la region que infesta a los principales cultivos de frutas. La implementacion de la Tecnica del Insecto Esteril (TIE) como parte de un manejo integrado en areas extensivas contra esta especie requiere ensayos que demuestren que los insectos producidos en forma masiva y esterilizados son capaces de sobrevivir en el campo y aparearse con las hembras silvestres. Se comparo la supervivencia de individuos de una linea de laboratorio, tanto irradiados como no irradiados con la de individuos de una poblacion natural. Los dos tratamientos de moscas de laboratorio sobrevivieron mas tiempo que las salvajes durante los 8 dias y en las condiciones ensayadas. La dosis de radiacion (70 Gy.) no afecto la supervivencia de las moscas criadas en laboratorio. Nuestros resultados mejoran las perspectivas de integrar la TIE en el control de las poblaciones argentinas de A. fraterculus. (author)

Gomez Cendra, P.; Vilardi, J. [Depto. Ecologia, Genetica y Evolucion, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, (1428) Buenos Aires (Argentina); Segura, D.; Cladera, J. [Instituto de Genetica, INTA Castelar, CC25, (1712), Buenos Aires (Argentina); Allinghi, A. [Comision Nacional de Energia Atomica, CNEA, Buenos Aires (Argentina)



Moléculas orgánicas no-rígidas  

NASA Astrophysics Data System (ADS)

Se destaca la importancia del estudio espectroscópico ab initio de una serie de moléculas no-rígidas detectadas en el medio interestelar (acetona, dimetil-eter, etanol, metanol, metilamina, ldots), así como los últimos avances del desarrollo de la metodología para el tratamiento teórico de estas especies. Se describe, a modo de ejemplo, el análisis del espectro roto-torsional de la molécula de glicoaldehido que ha sido recientemente detectada en el centro Galáctico Sagitario B2 (N) [1]. Esta especie presenta dos movimientos de gran amplitud que interaccionan, descansan en el Infrarrojo Lejano y le confiere propiedades no-rígidas. La molécula puede existir en posiciones cis y trans y presenta cinco confórmeros estables, tres de simetría Cs (I, II y IV) y un doble mínimo trans de simetría C1 (III) . La conformación favorita, I, presenta simetría Cs y se estabiliza por la formación de un puente de hidrógeno entre los grupos OH y C=O. Los mínimos secundarios II, III, y IV se han determinado a 1278.2 cm-1 (trans, Cs), 1298.8 cm-1 (trans, C1) y 1865.2 cm-1 (cis, Cs) con cálculos MP4/cc-pVQZ que incluyen sustituciones triples. Para determinar que vibraciones interaccionan con las torsiones, se ha realizado un análisis armónico en los mínimos. Las frecuencias fundamentales armónicas correspondientes al mínimo I se han calculado en 213.4 cm-1 (torsión C-C) y 425.7 cm-1 (torsión OH). Es de esperar que tan sólo dos vibraciones, la flexión del grupo C-C-O y el aleteo del hidrógeno del grupo aldehídico puedan desplazar el espectro torsional de la molécula aislada. Para determinar el espectro torsional, se ha determinado la superficie de potencial en dos dimensiones mediante el cálculo ab initio de las geometrías y energías de 74 conformaciones seleccionadas. Estas últimas se han ajustado a un doble serie de Fourier. A partir de la PES y de los parámetros cinéticos del Hamiltoniano vibracional se han obtenido frecuencias e intensidades. Las frecuencias fundamentales se han calculado en 208.0 cm-1 (torsión C-C) y 349.9 cm-1 (torsión OH). Se discute el método de cálculo que se ha empleado para la clasificación de los niveles. Los niveles rotacionales se han determinado empleando el método desarrollado para el estudio del ácido acético [2]. Se emplean la base de funciones rotacionales de [3]. A partir de los niveles se han determinado las constantes rotacionales y las constantes de distorsión centrífuga que se comparan con las experimentales de Herbst et al [3].

Senent Díez, M. L.


Regulando la Enfermedad a través de la Definición y la Restricción: Profesionales de la Salud Hablan sobre el VIH/SIDA1  

PubMed Central

Resumen Las profesiones de la salud tienen un papel social dual. Por un lado, velan por el mantenimiento de la salud de la población protegiendo el bien común. Por el otro, dictaminan las formas saludables, y por lo tanto socialmente apropiadas, de ser, actuar y pensar. Este último papel, está más ligado al control social de la población que a una preocupación altruista hacia la misma. A través de esta supervisión y control, se construyen los sujetos a los cuales todos/as debemos aspirar a ser para gozar de aceptación social. Los/as profesionales de la salud han jugado un rol protagónico en dicho proceso, siendo los agentes que delimitan y definen lo que es enfermo vs. saludable, útil vs. inútil, apropiado vs. inapropiado. En el caso de la epidemia del VIH, este esfuerzo se ha hecho cada vez más vigente ya que estos/as profesionales juegan un papel importante en el tratamiento de las personas que viven con VIH/SIDA (PVVS). Sin embargo, su función está plasmada de definiciones que sirven para criminalizar a las PVVS. El objetivo de este estudio fue explorar la manera en que una muestra de profesionales de la salud en Puerto Rico construyen a las PVVS. Con este propósito, entrevistamos 80 profesionales de la salud y estudiantes de estas profesiones. Estas entrevistas fueron grabadas, transcritas y sometidas a un análisis de discurso. Los resultados reflejaron que según las personas participantes: 1) la PVVS no es una persona “normal” o funcional bajo los estándares sociales debido a que su salud no se los permite, 2) representa una carga para la sociedad incluyendo familiares, amigos/as, el mundo del trabajo, e incluso para el gobierno, 3) debe ser vigilada porque representa un riesgo para la persona seronegativa que es descrita como saludable y productiva, y 4) necesita que su salud y conducta sexual sean controladas por vía legal y/o por las personas que representan las instituciones sociales, como lo son los/as profesionales de la salud. En este artículo abordamos el potencial rol de la psicología para servir como vehículo de reconstrucción de dichas nociones, tomando en consideración su propio rol en la formación y mantenimiento de dicho sujeto socialmente deseable. PMID:22025907

Rivera, Souhail Malavé; Díaz, Nelson Varas



Visual Inspection after Acetic Acid (VIA) Is Highly Heterogeneous in Primary Cervical Screening in Amazonian Peru  

PubMed Central

Background Conventional cytology (Pap) and visual inspection after the application of acetic acid (VIA) are currently used in primary screening in Peru. Studies suggest that the quality of VIA is highly variable. Over 36 000 women were screened with Pap and VIA in the TATI (Tamizaje y Tratamiento Inmediato de Lesiones Cervico-uterinas) project conducted in Amazonian Peru. Within a nested study to compare several screening techniques (C-TATI), a total of 5435 women were additionally screened with liquid-based cytology (LBC) and high-risk human papillomavirus testing (HR-HPV). We investigate the variation of positivity rates of VIA, Pap, LBC and HR-HPV in C-TATI and of VIA in the full TATI intervention. Methods At the screening visit, midwives collected three cervical samples for Pap, LBC and HC2 before performing VIA. The dispersion factor “D” (D = Pearson chi-square value/degrees-of-freedom) was used to measure the variability of tests results. Within C-TATI, the variability of positivity rates of VIA, Pap, LBC and HR-HPV was also graphically assessed with box- and scatter plots by midwife and month of screening. Funnel plots and smoothed scatter plots were used to correlate the variation of VIA by the number of examinations performed by each midwife over the full TATI intervention. Results Consistently over TATI, VIA results were highly variable, independently of the examiner, the time when the test was performed and the number of tests the examiner performed (D>6, p-values<0.001). In C-TATI, VIA results varied the most while those of HR-HPV varied the least (Ds>25, p-values<0.001 for VIA, Ds<1.6, p-values>0.05 for HR-HPV). No evidence for correlation between the number of VIAs done per midwife and the variability of VIA results was observed. Conclusion The lack of over-dispersion for HR-HPV detection suggests that the variable VIA results do not reflect true variation in underlying disease, but a lack of consistency in human judgement. PMID:25635965

Almonte, Maribel; Ferreccio, Catterina; Luciani, Silvana; Gonzales, Miguel; Delgado, Jose M.; Santos, Carlos; Alvarez, Manuel; Cuzick, Jack; Sasieni, Peter



Effect of acclimation to outdoor condition on the sexual performance of mass-produced Medflies (Diptera: Tephritidae)  

SciTech Connect

Application of the sterile insect technique (SIT) as part of integrated area-wide programs to control the Mediterranean fruit fly (medfly) Ceratitis capitata (Wiedemann) require that the released males attract wild females and transfer sterile sperm. However, knowledge about male sexual performance after they are released is scarce. We conducted a study to evaluate male sexual performance in field cage tests, according to standard quality control procedures. Mass-reared 5-d-old sterile males from the genetic sexing strain VIENNA 7mix2000 were acclimated for 0, 1, and 3 d to outdoor conditions before competing with wild males for wild females. Although the proportion of mating (PM) in the test was satisfactory, the resulting relative sterility index (RSI) data showed no significant differences among the treatments. The data indicate that pre-conditioning males to outdoor conditions in Madeira did not confer an advantage in field cage sexual performance. (author) [Spanish] La aplicacion de la tecnica del insecto esteril (TIE) como parte de un programa integrado de amplio efecto para el control de la mosca mediterranea de la fruta Ceratitis capitata (Wiedemann) requiere que los machos liberados atraigan las hembras naturales y transfieran su esperma. Sin embargo, el conocimiento del desempeno sexual de los machos despues de ser liberados es muy escaso. Nosotros realizamos un estudio para evaluar el desempeno sexual de los machos en pruebas usando jaulas del campo, segun los procedimientos estandardizados de calidad. Machos esteriles de 5 dias de edad de la raza que separa los sexos geneticamente VIENNA 7mix2000 criados en masa fueron aclimatados por 0, 1 y 3 dias en condiciones de campo antes de competir con machos naturales para las hembras naturales. Aunque la proporcion del apareamiento en la prueba fue satisfactorio, el indice relativo de esterilidad (IRS) resultante no mostro ninguna diferencia significativa entre los tratamientos. Los datos indicaron que al condicionar los machos anteriormente a las condiciones de campo en Madeira no conferio ventaja alguna en el desempeno sexual en la jaula de campo. (author)

Pereira, R.; Silva, N.; Quintal, C.; Abreu, R.; Andrade, J.; Dantas, L. [Programa Madeira-Med, Estrada Eng. Abel Vieira, 262, 9135-260 Camacha, Madeira (Portugal)



Impact of Chloroquine on Viral Load in Breast Milk  

PubMed Central

Summary The anti-malarial agent chloroquine has activity against HIV. We compared the effect of chloroquine (n = 18) to an anti-malarial agent without known anti-HIV-activity, sulfadoxine-pyrimethamine (n = 12), on breast milk HIV RNA levels among HIV-infected breastfeeding women in Zambia. After adjusting for CD4 count and plasma viral load, chloroquine was associated with a trend towards lower levels of HIV RNA in breast milk compared with sulfadoxine-pyrimethamine (P 0.05). Higher breastmilk viral load was also observed among women receiving presumptive treatment = for symptomatic malaria compared with asymptomatic controls and among controls reporting fever in the prior week. Further research is needed to determine the potential role of chloroquine in prevention of HIV transmission through breastfeeding. Impacte de la chloroquine sur la charge virale dans le lait maternelle La chloroquine, agent antimalarique, a une activité contre le VIH. Nous avons comparé l’effet de la chloroquine à celui d’un autre agent antimalarique, la sulfadoxine-pyrimethamine, dont l’activité sur le VIH n’est pas connue, en mesurant les taux d’ARN de VIH dans le lait maternel de femmes allaitantes infectées par le VIH en Zambie. Après ajustement pour les taux de CD4 et la charge virale dans le plasma, la chloroquine comparée à la sulfadoxine pyrimethamine était associée à une tendance vers des teneurs plus bas en ARN de VIH dans le lait maternel (P = 0,05). Des charges virales plus élevées dans le lait maternel étaient aussi observées chez des femmes recevant un traitement présomptif pour des symptômes de malaria par rapport aux contrôles asymptomatiques et par rapport à des contrôles rapportant de la fièvre durant la première semaine. Des études supplémentaires sont nécessaires pour déterminer le rôle potentiel de la chloroquine dans la prévention de la transmission du VIH par l’allaitement maternel. mots clésVIH, malaria, allaitement maternel, chloroquine, sulfadoxine-pyrimethamine, charge virale du lait maternel, fièvre Impacto de la cloroquina en la carga viral de la leche materna El antimalárico cloroquina tiene actividad frente al VIH. Comparamos el efecto de la cloroquina (n = 18) frente a un antimalárico sin actividad anti-VIH conocida, la sulfadoxina-pirimetamina (n = 12), en los niveles de ARN en la leche materna de mujeres infectadas con VIH, en Zambia. Después de ajustar para recuento de CD4 y la carga viral en plasma, se asoció a la cloroquina con una tendencia hacia menores niveles de ARN del VIH en leche materna, comparado con la sulfadoxina pirimetamina (P = 0.05). También se observó una mayor carga viral en la leche materna de mujeres recibiendo tratamiento presuntivo para malaria sintomática, que en los controles asintomáticos y controles que habáan reportado fiebre la semana anterior. Es necesario realizar más estudios para determinar el papel potencial de la cloroquina en la prevención de la trasmisión de VIH a través de la lactancia materna. palabras claveVIH, malaria, lactancia materna, cloroquina, sulfadoxina pirimetamina, transmisión vertical, leche materna, carga viral, fiebre PMID:16772000

Semrau, Katherine; Kuhn, Louise; Kasonde, Prisca; Sinkala, Moses; Kankasa, Chipepo; Shutes, Erin; Vwalika, Cheswa; Ghosh, Mrinal; Aldrovandi, Grace; Thea, Donald M.



Modelizacion, control e implementacion de un procesador energetico paralelo para aplicacion en sistemas multisalida  

NASA Astrophysics Data System (ADS)

Cualquier sistema electronico que incluya un procesado o tratamiento de la senal, y ademas, algun tipo de actuador mecanico generalmente necesita, como minimo, dos tensiones diferentes de alimentacion. Excluyendo los sistemas de alimentacion distribuida, la solucion tecnica mas utilizada para proporcionar dos o mas tensiones consiste en las fuentes de alimentacion multisalida. En una fuente de alimentacion multisalida los diferentes circuitos que conforman cada salida comparten un mismo transformador de potencia optimizando coste, masa, y volumen. Las ventajas obtenidas con este procedimiento tienen en su contra el efecto que sobre cada salida individual provocan las demas en su conjunto debido, principalmente, a los efectos de los elementos parasitos de los componentes. Un cambio de carga en una de las salidas produce un transitorio que es visto por todas las demas como un efecto de impedancia cruzada, y al final del transitorio, la tension de cada salida es diferente respecto a la que tenian antes del transitorio. Este ultimo resultado se conoce como regulacion cruzada. La disminucion de los efectos de la regulacion cruzada ha sido objeto de estudio durante los ultimos anos. El objetivo ha sido el desarrollo de distintas estrategias que permiten, desde disminuir los efectos de la regulacion cruzada hasta los niveles deseables, a eliminarla completamente. El resultado final suele suponer una penalizacion sobre el diseno del sistema directamente proporcional al grado de regulacion a conseguir en las distintas salidas. Entre las soluciones propuestas para eliminar la regulacion cruzada las tecnicas de post-regulacion se han consolidado como la opcion mas aceptada ya que, pueden aplicarse a cualquier convertidor y no suponen ninguna complejidad adicional a la hora de plantear el diseno. En esta Tesis Doctoral se abordara el estudio de la tecnica conocida como postregulacion mediante transformador controlado, que si bien se ha empleado en convertidores resonantes, su modelizacion, y aplicacion en convertidores PWM, esta aun por estudiar y valorar. El primer Capitulo consiste en una breve introduccion al problema de la regulacion cruzada y la impedancia cruzada para posteriormente describir las tecnicas de post-regulacion actualmente mas empleadas, con especial atencion al post-regulador con transformador controlado. El Capitulo segundo trata del estudio de las caracteristicas estaticas del postregulador con transformador controlado. Partiendo de los estudios disponibles sobre el postregulador se plantean mejoras en su modo de actuacion y se discuten tres alternativas diferentes para controlar el transformador. Las dos primeras consisten en emplear un convertidor auxiliar Boost en sus dos modos de funcionamiento, continuo y discontinuo. La tercera consiste en controlar el transformador con una tension PWM directamente, sin filtrado. Finalmente se comprueba experimentalmente, para el estado estacionario, el funcionamiento del post-regulador para cada uno de los tres metodos de control. El Capitulo tercero trata de la dinamica de la salida controlada con el post-regulador cuando este emplea un convertidor auxiliar tipo Boost. Mediante la tecnica de promediado de variables de estado se propone el modelo de pequena senal, tanto para el modo continuo como para el modo discontinuo de funcionamiento del convertidor auxiliar. Los resultados mas significativos de esta seccion son las expresiones analiticas de las impedancias cruzadas y de la impedancia de la salida post-regulada. Como complemento al modelo de pequena senal se plantea un modelo de gran senal implementado sobre el simulador Pspice. Con este nuevo modelo se reproducen los resultados obtenidos con el modelo de pequena senal y ademas es posible simular los transitorios en las tensiones de salida ante cambios de carga. La modelizacion del convertidor cuando el transformador se controla con una tension PWM sin filtrar es el objetivo del Capitulo 4. En las secciones siguientes del Capitulo se plantea el correspondiente modelo de gran senal aplicado a un nuevo prototipo exper

Ferreres Sabater, Agustin


Capture-zone design in an aquifer influenced by cyclic fluctuations in hydraulic gradients  

NASA Astrophysics Data System (ADS)

Design of a groundwater pumping and treatment system for a wood-treatment facility adjacent to the tidally influenced Fraser River estuary required the development of methodologies to account for cyclic variations in hydraulic gradients. Design of such systems must consider the effects of these cyclic fluctuations on the capture of dissolved-phase contaminants. When the period of the cyclic fluctuation is much less than the travel time of the dissolved contaminant from the source to the discharge point, the hydraulic-gradient variations resulting from these cycles can be ignored. Capture zones are then designed based on the average hydraulic gradient determined using filter techniques on continuous groundwater-level measurements. When the period of cyclic fluctuation in hydraulic gradient is near to or greater than the contaminant travel time, the resulting hydraulic-gradient variations cannot be ignored. In these instances, procedures are developed to account for these fluctuations in the capture-zone design. These include proper characterization of the groundwater regime, assessment of the average travel time and period of the cyclic fluctuations, and numerical techniques which allow accounting for the cyclic fluctuations in the design of the capture zone. Résumé. L'étude d'un système de pompage et de traitement de l'eau souterraine d'une usine de traitement du bois proche de l'estuaire de la rivière Fraser, influencé par les marées, a nécessité la mise au point de méthodologies pour prendre en compte les variations cycliques de gradients hydrauliques. L'étude de tels systèmes doit considérer les effets de ces variations cycliques sur l'extraction des contaminants en phase dissoute. Lorsque la période des variations cycliques est très inférieure au temps de parcours du contaminant dissous entre la source et le point d'émergence, les variations du gradient hydraulique résultant de ces cycles peuvent être ignorées. Les zones d'extraction sont alors réalisées sur la base du gradient hydraulique moyen déterminé au moyen de techniques de filtrage sur des mesures continues de la piézométrie. Lorsque la période de la fluctuation cyclique dans le gradient hydraulique est proche de ou supérieure au temps de parcours du contaminant, les variations résultantes de gradient hydraulique ne peuvent plus être ignorées. Dans ces cas-là, des procédures ont été mises au point pour prendre en compte ces fluctuations dans la conception de la zone d'extraction. Celles-ci prennent en considération la caractérisation propre du régime de la nappe, l'évaluation du temps de parcours moyen et de la période des fluctuations cycliques, et des techniques numériques qui permettent de considérer les fluctuations cycliques dans la conception de la zone d'extraction. Resumen. El diseño de un sistema de bombeo y tratamiento de aguas subterráneas para una instalación de manufactura de madera que está próxima al estuario del río Fraser, sometido a la influencia de las mareas, ha requerido el desarrollo de metodologías para tener en cuenta las variaciones cíclicas de los gradientes hidráulicos. El diseño de tales sistemas debe considerar los efectos de las fluctuaciones cíclicas en la captura de contaminantes en fase disuelta. Cuando el período de la fluctuación cíclica es mucho menor que el tiempo de tránsito del contaminante disuelto entre el punto de entrada y el de descarga, se puede ignorar las variaciones del gradiente hidráulico provocadas por dichos ciclos. Las zonas de captura se diseñan entonces en función del gradiente hidráulico promedio, que se determina mediante técnicas de filtrado de medidas continuas del nivel piezométrico. Cuando el período de la fluctuación cíclica del gradiente hidráulico es comparable o mayor que el tiempo de tránsito del contaminante, no puede ignorarse las variaciones resultantes en el gradiente hidráulico. En ese caso, se tiene que desarrollar procedimientos para contar con las fluctuaciones en el diseño de las zonas de captura. Ello implica una ad

Zawadzki, Willy; Chorley, Don; Patrick, Guy



Breakfast of champions or kiss of death? Survival and sexual performance of protein-fed, sterile Mediterranean fruit flies (Diptera: Tephritidae)  

SciTech Connect

The sterile insect technique (SIT) is increasingly being used around the world to control Ceratitis capitata (Wiedemann) (Diptera: Tephritidae), the Mediterranean fruit fly as part of an area-wide integrated approach. One option that may improve the effectiveness of the SIT, by increasing the sexual competitiveness of released sterile males, consists of feeding males protein during the post-teneral stage, a diet that increases sexual performance of wild males. We examine the effects of diet on the successive hurdles males must overcome in order to inseminate females, i.e., joining leks, copulating females, having their sperm stored and inhibition of female remating. In addition, we address the effects of diet on post-release foraging success, longevity, and the ability to withstand starvation. While protein feeding universally increases the sexual success of wild males, its effect on sterile males varies with strain, experimental settings, and environmental conditions. In some cases, treatments that resulted in the best sexual performance were significantly associated with increased vulnerability to starvation. However, no particular diet affected the ability of sterile males to find nutrients in the field when these where available. We suggest it may be better to release relatively short-lived flies that are highly competitive, rather than long-lived, sexually ineffective ones. (author) [Spanish] El uso de la tecnica de insecto esteril (TIE) esta aumentando alrededor del mundo para el control de Ceratitis capitata (Wiedemann) (Diptera: Tephritidae), la mosca mediterranea de la fruta como parte de un enfoque integrado por toda el area. Una opcion que puede mejorar la eficiencia de TIE, por medio del aumento de la capacidad de los machos esteriles liberados para competir, consiste en la alimentacion de los machos con proteina durante la etapa de pos-teneral, una dieta que aumenta el desempeno sexual de los machos naturales. Nosotros examinamos los efectos de la dieta sobre los obstaculos sucesivos que los machos tienen que superar para inseminar las hembras, i.e., unir con otros machos en areas para el apareamiento, copula de las hembras, almacenar esperma e inhibir el re-apareamiento de hembras. Ademas discutimos los efectos de la dieta sobre el exito de su actividad forrajera despues de ser liberados, la longevidad y la habilidad para aguantar la inanicion. Mientras que la alimentacion con proteina universalmente aumentan el exito sexual de los machos naturales, su efecto sobre los machos esteriles varia segun la raza, el lugar de los experimentos y las condiciones ambientales. En algunos casos, los tratamientos que resultaron con mejor desempeno sexual fueron asociados significativamente con el aumento de la vulnerabilidad a la inanicion. Sin embargo, ninguna dieta en particular afecto la habilidad de los machos esteriles para encontrar nutrientes en el campo cuando fueron disponibles. Nosotros sugerimos que puede ser mejor el liberar moscas que tienen una vida relativamente corta y que son mas competidoras, en vez de moscas que tienen una vida larga y sexualmente inefectiva. (author)

Yuval, B.; Maor, M.; Levy, K. [Dept. of Entomology, Hebrew University, PO 12, Rehovot, 76100 (Israel); Kaspi, R. [Dept. of Entomology, University of California, Davis CA 95616 (United States); Taylor, P. [Dept. of Psychology, Macquarie University, NSW 2109 (Australia); Shelly, T. [USDA-APHIS, 41-650 Ahiki Street, Waimanalo, HI 96795 (United States)