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Sample records for peeter burk ilmar

  1. Burke and Nietzsche.

    ERIC Educational Resources Information Center

    Hawhee, Debra

    1999-01-01

    Explores the complex linkages between K. Burke and F. Nietzsche, particularly regarding Burke's concept of perspective by incongruity, motive, terministic screens, and dramatism. Focuses on how Nietzsche's philosophy helped shape Burke's views on the nature of language and the effects language produces. Considers Nietzsche's influence on Burke's…

  2. Teaching Burke Using Advertisements.

    ERIC Educational Resources Information Center

    Larson, Charles U.

    Kenneth Burke's concepts of identification, the five terms of dramatism, and strategic uses of ambiguity can be successfully taught to undergraduates if appropriate and familiar examples are used. Print and electronic advertising offer the instructor an up-to-date, familiar, and abundant source of classroom examples. Market segmentation models…

  3. Professor Jensen, Meet Miss Burks.

    ERIC Educational Resources Information Center

    Goldberger, Arthur S.

    This paper critically examines the portions of Arthur Jensen's books, "Genetics and Education" and "Educability and Group Differences," that concern Barbara Burks' 1928 study of adoptive families. Jensen cites the low correlations of children's IQs with measures of home environment from Burks' study as evidence that environment plays only a minor…

  4. Kenneth Burke's Discovery of Dramatism.

    ERIC Educational Resources Information Center

    Feehan, Michael

    1979-01-01

    Discusses how "Twelve Propositions by Kenneth Burke on the Relation between Economics and Psychology" generates a new synthesis of Marx and Freud and foreshadows Burke's system of dramatism. His conception of self, the community, and communication come together in a serious argument for drama as a model of human relations. (JMF)

  5. Burke and Academia: Revenge of the Specialists.

    ERIC Educational Resources Information Center

    Lambkin, David J.

    Kenneth Burke was a college dropout who did not enjoy notable success until quite late in life. His major interest was the development of a meta-theory of language, which he called "rhetoric." Denied the resources and material rewards of academia, Burke was both scapegoated and redeemed by the academic community. Furthermore, the scapegoaters and…

  6. Catolaccus grandis (Burks)(Hymenoptera: Pteromalidae)

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Catolaccus grandis is an ectoparasitoid of the boll weevil classified initially within the genus Heterolaccus (Burks 1954). It was first introduced to the U.S. during the early 1970’s and released in experimental fields in Mississippi State, MS (Johnson et al. 1973). Researchers observed encouraging...

  7. Intercultural Communication Research: A Burke's Eye View.

    ERIC Educational Resources Information Center

    Jones, Tricia S.

    Kenneth Burke's concepts of rhetoric, dramatism, terministic screens (perceptual filters), and identification are used in this paper to justify and direct intercultural communication research. Three intercultural methodologies--cultural variable analysis, componential analysis, and ethnomethodology--are examined in the paper using these concepts.…

  8. Nietzsche contra Burke: The Melodrama in Dramatism.

    ERIC Educational Resources Information Center

    Desilet, Gregory

    1989-01-01

    Examines Kenneth Burke's and Friedrich Nietzsche's similar understanding of the hortatory nature of language-using, weighed against their radically differing conceptions of the negative, which allows a distinction between two genres of dramatism, and illustrates contrasting orientations toward symbolic activity in general. (SR)

  9. Antithetical Ethics: Kenneth Burke and the Constitution.

    ERIC Educational Resources Information Center

    Anderson, Virginia

    1995-01-01

    Shows how the textuality of the United States Constitution, the most venerable of classic democratic icons, might be exploited to nurture postmodern ethics. Shows how Kenneth Burke's reading of the Constitution accords with and augments the postmodern theories of J.-F. Lyotard and S. Jarratt. Discusses a postmodern Constitution and the…

  10. Burke Bingo: Using Active Learning to Introduce Dramatism

    ERIC Educational Resources Information Center

    Krueger, Ben

    2011-01-01

    Kenneth Burke is typically regarded as the single most significant figure in 20th-century rhetorical studies. Undergraduate textbooks in rhetorical criticism, rhetorical theory, and communication theory typically include coverage of Burke's theory of dramatism. In this article, the author describes a classroom activity dubbed "Burke Bingo" that…

  11. Peter Elbow, Kenneth Burke, and the Idea of Magic.

    ERIC Educational Resources Information Center

    Briggs, John C.

    1991-01-01

    Asserts that the works of Peter Elbow and Kenneth Burke are valuable reference points because they problematize fundamental assumptions within the field of composition that pluralism and factional perspectives typically elide. Describes Elbow's rhetorical magic and shows how magic illuminates Burke's effort. Wonders whether Elbow and Burke…

  12. Drooping Methodically: Burke's Argument for a Negative Education.

    ERIC Educational Resources Information Center

    Kastely, James

    Kenneth Burke's essay, "Linguistic Approach to the Problem of Education," argues for tempering a positive attitude toward education--"drooping" should be the norm. "Drooping" would be the antithesis of an education designed primarily to facilitate students' uncritical movement into the workforce. Burke explores how a rhetor might teach responsibly…

  13. Kenneth Burke's Appendicitis: A Feminist's Case for Complaint.

    ERIC Educational Resources Information Center

    Worsham, Lynn

    1991-01-01

    Demonstrates the relationship of disease and language in Kenneth Burke's work, tracing it to a chronic symbolic condition, the symptoms of which are found in his frequent recourse to the genre of the appendix and its close relations--the postscript, the addendum, and the afterward. Discusses Burke's work from a feminist and anatomical perspective.…

  14. Synecdoche against Metonymy: Burke, Freire, and Writing Instruction.

    ERIC Educational Resources Information Center

    Hunter, Paul

    1990-01-01

    Argues that the metaphor of writing as a tool is still used because the ideas of Kenneth Burke have not been applied comprehensively. Argues further that Burke's "A Grammar of Motives" implies a radical change in what it means to teach students to analyze and produce texts--a change leading up to and beyond Freireian pedagogy. (RS)

  15. 77 FR 51564 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-24

    ... National Park Service Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum... Thomas Burke Memorial Washington State Museum (Burke Museum), University of Washington, has completed an... contact the Burke Museum. Repatriation of the human remains to the tribe named below may occur if...

  16. Obituary: Edward W. Burke, Jr. (1924-2011)

    NASA Astrophysics Data System (ADS)

    Bloomer, Raymond, Jr.

    2011-12-01

    Dr. Edward W. Burke Jr. passed away on June 15, 2011, after suffering a heart attack. Dr. Burke devoted his professional life to the research and teaching of physics and astronomy at King College in Bristol, Tennessee. Edward W. Burke, Jr., was born in Macon, Georgia, on September 16, 1924. He was a Navy veteran, having been commissioned as an ensign in 1944. He served in the Pacific near the end of World War II. He proceeded to complete his undergraduate degree in mathematics from Presbyterian College in 1947 and pursued the M.S. and Ph.D. in physics (1949 and 1954, respectively) at the University of Wisconsin. Under the direction of Professor Julian Mack, his thesis was titled "Isotope Shift in the Spectra of Boron." Although he did research in atomic spectra in the early part of his career, his interest in astronomy and variable stars in particular were his primary interests during his long academic career. Dr. Burke began his illustrious career at King College in 1949. He initiated the astronomy program there in 1950, included constructing a 12.5 inch Newtonian telescope, homemade as was most everything in those days. Many of his students learned about photometry at the Burke Observatory on the college campus. Burke was known for his trips to the Kitt Peak and Lowell observatories accompanied by undergraduate students on his trips, all of which were made by automobile which he preferred over flying. His initial interest in Ap stars later broadened into variable and especially eclipsing binary stars. His motivation was maintained by his desire to have his students experience basic research and to spark their interest in advanced degrees. Numerous students achieved advanced science and medical degrees because of Burke's encouragement and mentoring. In 1959, Dr. Burke was awarded a Fulbright professorship and traveled to Chile where he taught physics for a year in the Engineering School at the University of Chile in Santiago. He worked to establish a physics

  17. Comment and Response: A Relation of Agency to Act in Dramatism: A Comment on "Burke's Act."

    ERIC Educational Resources Information Center

    College English, 1985

    1985-01-01

    Presents a criticism of Clayton W. Lewis's analysis of Burke's "A Rhetoric of Motives" arguing that Lewis risks overstressing act and neglecting the necessary connection between agency and act in Burke's theory of dramatism. Includes Lewis's response. (HTH)

  18. Sizing Up the Situation: Kenneth Burke's Dramatistic Frames.

    ERIC Educational Resources Information Center

    Krug, Linda T.

    Testing Kenneth Burke's theory on dramatistic frames, the attitudes and motivations reflected in the rhetoric of Watergate participants were analyzed in terms of literary forms: epic, tragic, comic, elegiac, satiric, burlesque, grotesque, and didactic. Nixon tried to transcend the Watergate conflict by stressing the greatness of his achievements…

  19. Burke, Nietzsche, Lacan: Three Perspectives on the Rhetoric of Order.

    ERIC Educational Resources Information Center

    Thomas, Douglas

    1993-01-01

    Examines the complex relationship between rhetoric and order in the works of Kenneth Burke, Friedrich Nietzsche, and Jacques Lacan. Argues for three differing, yet complementary, views of rhetoric and order, each having a corresponding epistemology and axiology. Concludes with an analysis of the construction of order in Thomas Hobbe's "Leviathan."…

  20. Division, Unity, and Consciousness Raising: Burke and Ong on Technology.

    ERIC Educational Resources Information Center

    Palmeri, Anthony J.

    In an effort to contribute to the dialogue on the effects of the intensification of technology upon the structure and dynamics of human communication, this paper examines the views of technology in the works of Kenneth Burke and Walter Ong. The paper argues that their theories can be compatible, that Ong's view of writing as a technology which…

  1. "Verbal Atom Cracking": Burke and a Rhetoric of Reading.

    ERIC Educational Resources Information Center

    Enos, Theresa

    "Verbal atom cracking," according to Kenneth Burke, entails a process where the reader reconstructs what the writer has constructed--a necessary process before the reader can begin deconstructing. Foregrounding opposites, rather than looking for apposites, may not be the best way to approach discourse that covers especially esoteric…

  2. International Videoconferencing: A Reaction to Burke et al.

    ERIC Educational Resources Information Center

    Ritzel, Dale O.

    2010-01-01

    In this issue of the "American Journal of Health Education," Burke et al. provide a case review of an international videoconference between a U.S. and a German university. The authors highlighted the benefits and opportunities of international videoconferencing as well as the relevant limitations. Videoconferencing is an interactive tool that…

  3. 75 FR 36671 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-28

    ... the Federal Register (75 FR 5105-5106, February 1, 2010). In the Federal Register, paragraph number 7... National Park Service Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum... funerary objects in the possession of the Thomas Burke Memorial Washington State Museum (Burke...

  4. "The Piety of Degradation": Kenneth Burke, the Bureau of Social Hygiene, and "Permanence and Change"

    ERIC Educational Resources Information Center

    Jack, Jordynn

    2004-01-01

    Kenneth Burke's employment with the Bureau of Social Hygiene informed his rhetorical theory in the 1930s. Between 1926 and 1930, Burke researched criminology and drug addiction and ghostwrote a book for Colonel Arthur Woods, Dangerous Drugs. An investigation of archives indicates that this research left its mark on Burke's Permanence and Change…

  5. "The Piety of Degradation": Kenneth Burke, the Bureau of Social Hygiene, and "Permanence and Change"

    ERIC Educational Resources Information Center

    Jack, Jordynn

    2004-01-01

    Kenneth Burke's employment with the Bureau of Social Hygiene informed his rhetorical theory in the 1930s. Between 1926 and 1930, Burke researched criminology and drug addiction and ghostwrote a book for Colonel Arthur Woods, "Dangerous Drugs". An investigation of archives indicates that this research left its mark on Burke's "Permanence and…

  6. Obituary: Edward W. Burke, Jr. (1924-2011)

    NASA Astrophysics Data System (ADS)

    Bloomer, Raymond, Jr.

    2011-12-01

    Dr. Edward W. Burke Jr. passed away on June 15, 2011, after suffering a heart attack. Dr. Burke devoted his professional life to the research and teaching of physics and astronomy at King College in Bristol, Tennessee. Edward W. Burke, Jr., was born in Macon, Georgia, on September 16, 1924. He was a Navy veteran, having been commissioned as an ensign in 1944. He served in the Pacific near the end of World War II. He proceeded to complete his undergraduate degree in mathematics from Presbyterian College in 1947 and pursued the M.S. and Ph.D. in physics (1949 and 1954, respectively) at the University of Wisconsin. Under the direction of Professor Julian Mack, his thesis was titled "Isotope Shift in the Spectra of Boron." Although he did research in atomic spectra in the early part of his career, his interest in astronomy and variable stars in particular were his primary interests during his long academic career. Dr. Burke began his illustrious career at King College in 1949. He initiated the astronomy program there in 1950, included constructing a 12.5 inch Newtonian telescope, homemade as was most everything in those days. Many of his students learned about photometry at the Burke Observatory on the college campus. Burke was known for his trips to the Kitt Peak and Lowell observatories accompanied by undergraduate students on his trips, all of which were made by automobile which he preferred over flying. His initial interest in Ap stars later broadened into variable and especially eclipsing binary stars. His motivation was maintained by his desire to have his students experience basic research and to spark their interest in advanced degrees. Numerous students achieved advanced science and medical degrees because of Burke's encouragement and mentoring. In 1959, Dr. Burke was awarded a Fulbright professorship and traveled to Chile where he taught physics for a year in the Engineering School at the University of Chile in Santiago. He worked to establish a physics

  7. Triaxial Burke-Schumann Flames with Applications to Flame Synthesis

    NASA Technical Reports Server (NTRS)

    Chao, B. H.; Axelbaum, R. L.; Gokoglu, Suleyman (Technical Monitor)

    2000-01-01

    The problem of a flame generated by three coaxial flows is solved by extending the Burke-Schumann methodology to include a third stream. The solution is particularly relevant to flame synthesis wherein multiple tubes are often employed either to introduce inert as a diffusion barrier or to introduce more than two reactants. The general problem is solved where the inner and outer tubes contain reactants and the middle tube contains either an inert or a third reactant. Relevant examples are considered and the results show that the triaxial Burke-Schumann flame can be substantially more complicated than the traditional Burke-Schumann flame. When the middle flow is inert the flame temperature is no longer constant but increases axially, reaching a maximum at the flame centerline. At the exit the flame does not sit on the tube exit but instead resides between the inner and outer tubes, resulting in an effective barrier for particle build-up on the burner rim. For the case of a third reactant in the middle flow, synthesis chemistry where the inner reaction is endothermic and the outer reaction is exothermic is considered. In addition to showing the flame temperature and flame shape, the results identify conditions wherein reaction is not possible due to insufficient heat transfer from the outer flame to support the inner flame reaction.

  8. 76 FR 58033 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-19

    ..., University of Washington, Seattle, WA AGENCY: National Park Service, Interior. ACTION: Notice. SUMMARY: The... Lape, Burke Museum, University of Washington, Box 353010, Seattle, WA 98195-3010, telephone (206) 685... in the possession of the Burke Museum, University of Washington, Seattle, WA. The human remains...

  9. A Rhetorician Ponders Technology; or, Why Kenneth Burke Never Owned a "Personal" Computer.

    ERIC Educational Resources Information Center

    Keller, Dale S.

    1996-01-01

    Considers the interaction between rhetoric and technology by perusing selected writings of Kenneth Burke. Contends that while Burke did not exactly express disdain for technology, he saw it as impacting on society in dangerous ways. Urges renewed commitment to the critical function which rhetoric provides as a safeguard in an increasingly…

  10. 75 FR 36672 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-28

    ... National Park Service Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum... Washington State Museum (Burke Museum), University of Washington, Seattle, WA. The human remains were removed... sole responsibility of the museum, institution, or Federal agency that has control of the...

  11. "More Than Lessons in How To Read": Burke, Freud, and the Resources of Symbolic Transformation.

    ERIC Educational Resources Information Center

    Quandahl, Ellen

    2001-01-01

    Argues that Kenneth Burke used "The Interpretation of Dreams," as well as other works by Sigmund Freud, as a lesson on reading, taking over the central tropes of dreamwork and making them broadly dialectical rather than strictly psychoanalytic terms. Suggests that Freud's "tropology" of dreaming is crucial for reading Burke. (SG)

  12. Burke's Dialogic Theory: An Epistemology of Interpretive Practice for Poetry Therapy.

    ERIC Educational Resources Information Center

    Reed, Melissa Ann

    2001-01-01

    Summarizes K. Burke's dialogic theories and exemplifies how they describe not only Edward Burne-Jones's interpretations of his paintings, but also his painted interpretations of poetry. Discusses how Burke's epistemology of interpretive practice contributes to the discipline of poetry therapy. (SG)

  13. Debate and the Destruction of Friendship: An Analysis of Fox and Burke on the French Revolution.

    ERIC Educational Resources Information Center

    Weaver, Bruce J.

    1981-01-01

    Examines the role of parliamentary debate in the demise of the friendship between Fox and Burke over the issue of the French Revolution and English domestic reform. Investigates the drawing out of Fox's position and the polarization of opinion in Commons by Burke's rhetorical destruction of traditional Whig principles. (JMF)

  14. Equipment for Thinking: Or Why Kenneth Burke Is Still Worth Reading

    ERIC Educational Resources Information Center

    Richards, Jennifer

    2015-01-01

    In a market place crowded with practical rhetoric books what educational value could a challenging work such as Kenneth Burke's "A Rhetoric of Motives" (1950) possibly have? Burke knows but doesn't use the terminology of the classical art and rather than analysing the persuasive rhetoric of well-known speeches to equip us with…

  15. 78 FR 59955 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-30

    .... Consultation A detailed assessment of the human remains was made by the Burke Museum professional staff in... American ancestry. Pursuant to 25 U.S.C. 3001(2), there is a relationship of shared group identity that...

  16. Kenneth Burke and Susanne K. Langer on Drama and its Audiences.

    ERIC Educational Resources Information Center

    Rod, David K.

    1986-01-01

    Compares the views of Burke and Langer, emphasizing their agreement that the potential of dramatic works to elicit desired responses from audiences lies in the element of formal expressiveness, which in effect defines ideal audiences. (MS)

  17. Dynamic response of a pulsed Burke-Schumann diffusion flame

    NASA Technical Reports Server (NTRS)

    Sheu, Jyh-Cherng; Stocker, Dennis P.; Chen, Lea-Der

    1995-01-01

    Turbulent flames are often envisioned as an ensemble of random vortices interacting with the combustion process. A better understanding of the vortex-flame interactions therefore would be useful in improving the modeling of turbulent diffusion flames. Substantial simplification may be made by investigating controlled interactions in a laminar flame, as opposed to random interactions in a turbulent flame. The general goals of the research project are to improve our understanding of (1) the influence of buoyancy on co-flow diffusion flames and (2) the effects of buoyancy on vortex-flame interactions in co-flow diffusion flames. As a first step toward objective (2), we conducted a joint experimental and numerical investigation of the vortex-flame interaction. Vortices were produced by mechanically pulsing the fuel flow at a low frequency, e.g., 10 Hz. Experiments were conducted using a nonflickering Burke-Schumann flame in both microgravity (mu-g) and normal gravity (1g) as a means of varying the buoyant force without modification of the pressure (i.e., density). The effects of buoyant convection may then be determined by a comparison of the mu-g and 1g results. The mu-g results may also reveal the important mechanisms which are masked or overwhelmed by buoyant convection in 1g. A numerical investigation was conducted using a validated, time-accurate numerical code to study the underlying physics during the flame interaction and to assist the interpretation of the experimental results.

  18. Geology and paleontology of five cores from Screven and Burke counties, eastern Georgia

    USGS Publications Warehouse

    Edwards, Lucy E.

    2001-01-01

    Five deep stratigraphic test holes were drilled from 1991 to 1993 in support of multidisciplinary investigations to determine the stratigraphy of Upper Cretaceous and Tertiary sediments of the coastal plain in east-central Georgia. Cored sediment and geological logs from the Millhaven test hole in Screven County and the Girard and Millers Pond test holes in Burke County are the primary sources of lithologic and paleontologic information from this report. Lithologic and paleontologic information from the Thompson Oak and McBean test holes in Burke County supplements the discussion of stratigraphy and sedimentation in the updip part of the study area near the Millers Pond test hole.

  19. Functional Characterization and Evaluation of In Vitro Protective Efficacy of Murine Monoclonal Antibodies BURK24 and BURK37 against Burkholderia pseudomallei

    PubMed Central

    Peddayelachagiri, Bhavani V.; Paul, Soumya; Makam, Shivakiran S.; Urs, Radhika M.; Kingston, Joseph J.; Tuteja, Urmil; Sripathy, Murali H.; Batra, Harsh V.

    2014-01-01

    Burkholderia pseudomallei, the causative agent of melioidosis has been recognized by CDC as a category B select agent. Although substantial efforts have been made for development of vaccine molecules against the pathogen, significant hurdles still remain. With no licensed vaccines available and high relapse rate of the disease, there is a pressing need for development of alternate protection strategies. Antibody-mediated passive protection is promising in this regard and our primary interest was to unravel this frontier of specific mAbs against Burkholderia pseudomallei infections, as functional characterization of antibodies is a pre-requisite to demonstrate them as protective molecules. To achieve this, we designed our study on in vitro-based approach and assessed two mAbs, namely BURK24 and BURK37, reactive with outer membrane proteins and lipopolysaccharide of the pathogen respectively, for their ability to manifest inhibitory effects on the pathogenesis mechanisms of B. pseudomallei including biofilm formation, invasion and induction of apoptosis. The experiments were performed using B. pseudomallei standard strain NCTC 10274 and a clinical isolate, B. pseudomallei 621 recovered from a septicemia patient with diabetic ailment. The growth kinetic studies of the pathogen in presence of various concentrations of each individual mAb revealed their anti-bacterial properties. Minimal inhibitory concentration and minimal bactericidal concentration of both the mAbs were determined by using standards of Clinical and Laboratory Standards Institute (CLSI) and experiments were performed using individual mAbs at their respective bacteriostatic concentration. As an outcome, both mAbs exhibited significant anti-Burkholderia pseudomallei properties. They limited the formation of biofilm by the bacterium and completely crippled its invasion into human alveolar adenocarcinoma epithelial cells. Also, the mAbs were appreciably successful in preventing the bacterium to induce

  20. 76 FR 58034 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-19

    ..., University of Washington, Seattle, WA AGENCY: National Park Service, Interior. ACTION: Notice. SUMMARY: The... of Washington, Box 353010, Seattle, WA 98195-3010, telephone (206) 685-3849. SUPPLEMENTARY... funerary objects in the possession of the Burke Museum, University of Washington, Seattle, WA. The...

  1. One Hundred Years of Reading Research: Successes and Missteps of Edmund Burke Huey and Other Pioneers

    ERIC Educational Resources Information Center

    Walczyk, Jeffrey J.; Tcholakian, Talar; Igou, Frank; Dixon, Alexa P.

    2014-01-01

    For more than 100 years, research on the psychology of reading has proliferated. In this article, the authors wish to help modern reading researchers understand the origins of the discipline and benefit from its history. This article draws heavily on Edmund Burke Huey's 1908 landmark volume "The Psychology and Pedagogy of Reading,"…

  2. 76 FR 58031 - Notice of Intent To Repatriate Cultural Items: Thomas Burke Memorial Washington State Museum...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-19

    ... (NIC) describing 4 individuals and 42 associated funerary objects removed from the Cedar Cave site was published in the Federal Register [72 FR 52391-52392, September 13, 2007]. The Burke Museum and Central... Items In 1953-1954, human remains were removed from the Cedar Cave Site (45-KT-20), in Kittitas...

  3. 76 FR 58039 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-19

    ... In 1953-1954, human remains and funerary objects were removed from the Cedar Cave Site (45-KT-20), in... Cedar Cave site was published in the Federal Register . The Burke Museum and Central Washington University have jointly repatriated these human remains and funerary objects from the Cedar Cave...

  4. A Case for Item-Level Indexing: The Kenneth Burke Papers at The Pennsylvania State University

    ERIC Educational Resources Information Center

    Sabre, Jeannette Mercer; Hamburger, Susan

    2008-01-01

    In light of numerous discussions about whether to follow Mark Greene and Dennis Meissner's suggestions to process lightly and broadly, valid reasons remain for continuing traditional practices for many literary correspondence collections. In this case study, the authors use the Kenneth Burke Papers in the Special Collections Library, Pennsylvania…

  5. 75 FR 434 - Notice of Intent to Repatriate Cultural Items: Thomas Burke Memorial Washington State Museum...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-05

    ... Museum, University of Washington, Seattle, WA AGENCY: National Park Service, Interior. ACTION: Notice... Memorial Washington State Museum (Burke Museum), University of Washington, Seattle, WA, that meet the... language group of Salish cultures. The Duwamish people primarily occupied this area, specifically the...

  6. Language as Sensuous Action: Sir Richard Paget, Kenneth Burke, and Gesture-Speech Theory

    ERIC Educational Resources Information Center

    Hawhee, Debra

    2006-01-01

    This somatic genealogy of Dramatism's core terms--symbolic action, attitude, identification--argues for the importance of keeping rhetoric, rhetorical theory, and rhetorical pedagogy more closely tied to bodies that generate, induce, and respond to rhetoric. It does so by examining Burke's use of Sir Richard Paget's theory that spoken language…

  7. The weevil genus Achia champion (Coleoptera: Curculionidae): new species associate with urvillea (Sapindaceae) and New Serjania Host Plant records for A. ancile Burke and A. affinis Hustache

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Three new species of the weevil genus Achia Champion are described: A. urvilleae Clark and Burke from the state of Santa Catarina, Brazil and Misiones Province, Argentina; A. uniformis Clark and Burke from Bolivia; and A. boliviana Clark and Burke from Bolivia and Salta and Santiago del Estero prov...

  8. BurkDiff: A Real-Time PCR Allelic Discrimination Assay for Burkholderia Pseudomallei and B. mallei

    PubMed Central

    Bowers, Jolene R.; Engelthaler, David M.; Ginther, Jennifer L.; Pearson, Talima; Peacock, Sharon J.; Tuanyok, Apichai; Wagner, David M.; Currie, Bart J.; Keim, Paul S.

    2010-01-01

    A real-time PCR assay, BurkDiff, was designed to target a unique conserved region in the B. pseudomallei and B. mallei genomes containing a SNP that differentiates the two species. Sensitivity and specificity were assessed by screening BurkDiff across 469 isolates of B. pseudomallei, 49 isolates of B. mallei, and 390 isolates of clinically relevant non-target species. Concordance of results with traditional speciation methods and no cross-reactivity to non-target species show BurkDiff is a robust, highly validated assay for the detection and differentiation of B. pseudomallei and B. mallei. PMID:21103048

  9. Burke County wheat feasibility study. [using ERTS 1 multispectral band scanner data taken over North Dakota

    NASA Technical Reports Server (NTRS)

    Kunkel, W. A.

    1974-01-01

    A feasibility study was conducted to determine whether wheat could be distinguished from other small grain crops in a selected spring wheat growing area in Burke County, North Dakota using a maximum likelihood classification program and ERTS 1 multispectral band scanner data. ERTS 1 data scenes were selected from passes made on June 5, 1973 and June 23, 1973. The Univac 1108 computer and the LARSYS pattern recognition software package were used in performing the classification. Results of the analysis are provided.

  10. Current-dependent extension of the Perdew-Burke-Ernzerhof exchange-correlation functional.

    PubMed

    Maximoff, Sergey N; Ernzerhof, Matthias; Scuseria, Gustavo E

    2004-02-01

    The probability current density is used in addition to the electron density and its gradient as a variable in the construction of an exchange-correlation functional. Starting from the Perdew-Burke-Ernzerhof generalized gradient approximation, we employ exact conditions to build a nonempirical exchange functional. Matching the correlation functional to that for exchange yields a current-dependent approximation for correlation. The resulting functional is given in a simple closed form. Application of this approximation to open shell atoms eliminates the artificial level splitting of formally degenerate states observed with generalized gradient approximations. PMID:15268348

  11. Assessment of the Perdew-Burke-Ernzerhof exchange-correlation functional

    NASA Astrophysics Data System (ADS)

    Ernzerhof, Matthias; Scuseria, Gustavo E.

    1999-03-01

    In order to discriminate between approximations to the exchange-correlation energy EXC[ρ↑,ρ↓], we employ the criterion of whether the functional is fitted to a certain experimental data set or if it is constructed to satisfy physical constraints. We present extensive test calculations for atoms and molecules, with the nonempirical local spin-density (LSD) and the Perdew-Burke-Ernzerhof (PBE) functional and compare our results with results obtained with more empirical functionals. For the atomization energies of the G2 set, we find that the PBE functional shows systematic errors larger than those of commonly used empirical functionals. The PBE ionization potentials, electron affinities, and bond lengths are of accuracy similar to those obtained from empirical functionals. Furthermore, a recently proposed hybrid scheme using exact exchange together with PBE exchange and correlation is investigated. For all properties studied here, the PBE hybrid gives an accuracy comparable to the frequently used empirical B3LYP hybrid scheme. Physical principles underlying the PBE and PBE hybrid scheme are examined and the range of their validity is discussed.

  12. Physical stratigraphy and hydrostratigraphy of Upper Cretaceous and Paleocene sediments, Burke and Screven Counties, Georgia

    USGS Publications Warehouse

    Falls, W.F.; Baum, J.S.; Prowell, D.C.

    1997-01-01

    Six geologic units are recognized in the Cretaceous and the Paleocene sediments of eastern Burke and Screven Counties in Georgia on the basis of lithologic, geophysical, and paleontologic data collected from three continuously cored testholes in Georgia and one testhole in South Carolina. The six geologic units are separated by regional unconformities and are designated from oldest to youngest as the Cape Fear Formation, the Middendorf Formation, the Black Creek Group (undivided), and the Steel Creek Formation in the Upper Cretaceous section, and the Ellenton and the Snapp Formations in the Paleocene section. The geologic units provide a spatial and temporal framework for the identification and correlation of a basal confining unit beneath the Midville aquifer system and five aquifers and five confining units in the Dublin and the Midville aquifer systems. The Dublin aquifer system is divided hydrostratigraphically into the Millers Pond, the upper Dublin, and the lower Dublin aquifers. The Midville aquifer system is divided hydrostratigraphically into the upper and the lower Midville aquifers. The fine-grained sediments of the Millers Pond, the lower Dublin, and the lower Midville confining units are nonmarine deposits and are present in the upper part of the Snapp Formation, the Black Creek Group (undivided), and the Middendorf Formation, respectively. Hydrologic data for specific sets of monitoring wells at the Savannah River Site in South Carolina and the Millers Pond site in Georgia confirm that these three units are leaky confining units and locally impede vertical ground-water flow between adjacent aquifers. The fine-grained sediments of the upper Dublin and the upper Midville confining units are marine-deltaic deposits of the Ellenton Formation and the Black Creek Group (undivided), respectively. Hydrologic data confirm that the upper Dublin confining unit regionally impedes vertical ground-water flow on both sides of the Savannah River. The upper Midville

  13. Some Further (Orthodox?) Bourdieusian Reflections on the Notions of "Institutional Habitus" and "Family Habitus": A Reply to Burke, Emmerich, and Ingram

    ERIC Educational Resources Information Center

    Atkinson, Will

    2008-01-01

    This article is the author's reply to the Burke, Emmerich, and Ingram response to his critique of the notions of '"institutional habitus" and "family habitus" in the sociology of education. It begins by welcoming the work done by the threesome to distance themselves from some of the clumsier uses of the terms in previous research but then, via a…

  14. The birthplace of planetary radio astronomy: The Seneca, Maryland observatory 50 years after Burke and Franklin's Jupiter radio emission discovery.

    NASA Astrophysics Data System (ADS)

    Garcia, L. N.; Thieman, J. R.; Higgins, C. A.

    2004-12-01

    Burke and Franklin's discovery of radio emissions from Jupiter in 1955 effectively marked the birth of the field of planetary radio astronomy. The discovery was made near Seneca, Maryland using the Department of Terrestrial Magnetism/Carnegie Institution of Washington's Mills Cross Array. Fifty years later there is very little evidence of this 96-acre X-shaped array of dipoles still in existence, nor evidence of any of the other antennas used at this site. The site, now known as the McKee Besher Wildlife Management Area, is owned by the State of Maryland Department of Natural Resources. Radio Jove, a NASA/GSFC education and public outreach project, will recognize the 50th anniversary of this discovery through an historic reenactment using their receiver and dual-dipole array system. Our search through the DTM/CIW archives, our visit to the site to look for evidence of this array, and other efforts at commemorating this anniversary will be described.

  15. Preliminary correlation of geologic units in three coreholes along the Savannah River in Burke and Screven Counties, Georgia

    SciTech Connect

    Falls, W.F. ); Prowell, D.C. ); Edwards, L.E.; Frederiksen, N.O.; Gibson, T.G.; Bybell, L.M.; Gohn, G.S. )

    1993-03-01

    Preliminary lithologic and paleontologic correlations of geologic units in three deep coreholes along the Savannah River in Burke and Screven Counties in Georgia show four Upper Cretaceous units and five Tertiary units in a dip-oriented cross section. The basal unit of the Upper Cretaceous section consists of nonmarine sediments and is stratigraphically equivalent to the Cape Fear Formation. The next two successive units vary from nonmarine and marginal-marine sediments in up-dip areas to more marine sediments in down-dip areas. These strata are equivalent to the Middendorf Formation and the Black Creek Group. The uppermost unit of the Cretaceous sediments is present only in the down-dip cores and consists predominantly of marginal-marine sediments. This unit is probably equivalent to the Peedee Formation in South Carolina. Units in the Tertiary sediments include at least two Paleocene units, two middle Eocene units, and an upper Eocene unit. The lower unit in the Paleocene, the Ellenton Formation, consists of marginal-marine and marine clays and sands, whereas, the upper unit in the Paleocene consists of nonmarine kaolinitic clays and coarse sands and is probably equivalent to the Williamsburg Formation. The two middle Eocene units consist of marine sands, clays, and limestones and are correlative with the Congaree and Santee Formation. The upper Eocene unit, the Barnwell Group, includes marginal-marine clays and sands in up-dip areas and marine sands, clays and limestones in down-dip areas.

  16. A DNS study of differential diffusion in nonpremixed reacting turbulent flows using a generalized Burke- Schumann formulation

    NASA Astrophysics Data System (ADS)

    Grimmett, Tamara Kaye

    2001-11-01

    Differential diffusion effects in a turbulent H2-O2 nonpremixed flame are investigated using DNS. A generalized Burke-Schumann formulation 1 that allows for differing mass and thermal diffusivities as well as finite-rate chemistry is used. The formulation is based on a three-step reduced mechanism with H as the only intermediate species. Preferential diffusion of H2 and the intermediate species H are considered. Heat release is assumed small such that there is no feed back on the flow field. The flow field is incompressible decaying isotropic turbulence. The objectives are to study the effect of differential diffusion of both fuel and intermediate species, and the effects of reaction rate, dilution and turbulence on differential diffusion. The effects of differential diffusion are characterized by the difference in element mixture fractions, Δ = ξH - ξO. Comparisons are made with the limiting cases of no reaction and a single step, infinite rate reaction. An evolution equation for Δ is derived for each of the three cases. With LeH2 ≠ 1 and LeH = 1, the peak conditional average temperature increases over the unity Lewis number case. But with LeH 2 ≠ 1 and LeH ≠ 1, the peak conditional temperature decreases below the unity Lewis number case, but increases on the oxidizer side. The effects of H2 and H differentially diffusing are found to be counteracting. For the nonreacting case, conditional Δ has a reverse `` S'' shape that is characteristic of differential diffusion. With reaction, the flame modifies the shape so a peak appears at the stoichiometric position. Varying the reaction rate is found to have little effect on Δ though reacting scalars that are used in the calculation of Δ are affected. With increasing dilution, the peak of the conditional average of Δ also increases. The shape of the conditional average of Δ for the lowest dilution was found to approach the reverse `` S'' shape of the nonreacting case. With more dilution, Δ exhibits more

  17. Hydrogeology and water quality of the Dublin and Midville aquifer systems at Waynesboro, Burke County, Georgia, 2011

    USGS Publications Warehouse

    Gonthier, Gerard J.

    2013-01-01

    The hydrogeology and water quality of the Dublin and Midville aquifer systems were characterized in the City of Waynesboro area in Burke County, Georgia, based on geophysical and drillers’ logs, flowmeter surveys, a 24-houraquifer test, and the collection and chemical analysis of water samples in a newly constructed well. At the test site, the Dublin aquifer system consists of interlayered sands and clays between depths of 396 and 691 feet, and the Midville aquifer system consists of a sandy clay layer overlying a sand and gravel layer between depths of 728 and 936 feet. The new well was constructed with three screened intervals in the Dublin aquifer system and four screened intervals in the Midville aquifer system. Wellbore-flowmeter testing at a pumping rate of 1,000 gallons per minute indicated that 52.2 percent of the total flow was from the shallower Dublin aquifer system with the remaining 47.8 percent from the deeper Midville aquifer system. The lower part of the lower Midville aquifer (900 to 930 feet deep), contributed only 0.1 percent of the total flow. Hydraulic properties of the two aquifer systems were estimated using data from two wellbore-flowmeter surveys and a 24-hour aquifer test. Estimated values of transmissivity for the Dublin and Midville aquifer systems were 2,000 and 1,000 feet squared per day, respectively. The upper and lower Dublin aquifers have a combined thickness of about 150 feet and the horizontal hydraulic conductivity of the Dublin aquifer system averages 10 feet per day. The upper Midville aquifer, lower Midville confining unit, and lower Midville aquifer have a combined thickness of about 210 feet, and the horizontal hydraulic conductivity of the Midville aquifer system averages 6 feet per day. Storage coefficient of the Dublin aquifer system, computed using the Theis method on water-level data from one observation well, was estimated to be 0.0003. With a thickness of about 150 feet, the specific storage of the Dublin aquifer

  18. Level II scour analysis for bridge 35 (BURKTH00310035) on Town Highway 31, crossing the West Branch Passumpsic River, Burke, Vermont

    USGS Publications Warehouse

    Boehmler, Erick M.; Degnan, James R.

    1998-01-01

    This report provides the results of a detailed Level II analysis of scour potential at structure BURKTH00310035 on Town Highway 31 crossing the West Branch Passumpsic River, Burke, Vermont (figures 1-8). A Level II study is a basic engineering analysis of the site, including a quantitative analysis of stream stability and scour (FHWA, 1993). Results of a Level I scour investigation also are included in appendix E of this report. A Level I investigation provides a qualitative geomorphic characterization of the study site. Information on the bridge, gleaned from Vermont Agency of Transportation (VTAOT) files, was compiled prior to conducting Level I and Level II analyses and is found in appendix D.

  19. Simulation and Particle-Tracking Analysis of Selected Ground-Water Pumping Scenarios at Vogtle Electric Generation Plant, Burke County, Georgia

    USGS Publications Warehouse

    Cherry, Gregory S.; Clarke, John S.

    2007-01-01

    The source of ground water to production wells at Vogtle Electric Generation Plant (VEGP), a nuclear power plant in Burke County, Georgia, was simulated under existing (2002) and potential future pumping conditions using an existing U.S. Geological Survey (USGS) MODFLOW ground-water flow model of a 4,455-square-mile area in the Coastal Plain of Georgia and South Carolina. Simulation results for three steady-state pumping scenarios were compared to each other and to a 2002 Base Case condition. The pumping scenarios focused on pumping increases at VEGP resulting from projected future demands and the addition of two electrical-generating reactor units. Scenarios simulated pumping increases at VEGP ranging from 1.09 to 3.42 million gallons per day (Mgal/d), with one of the scenarios simulating the elimination of 5.3 Mgal/d of pumping at the Savannah River Site (SRS), a U.S. Department of Energy facility located across the Savannah River from VEGP. The largest simulated water-level changes at VEGP were for the scenario whereby pumping at the facility was more than tripled, resulting in drawdown exceeding 4-8 feet (ft) in the aquifers screened in the production wells. For the scenario that eliminated pumping at SRS, water-level rises of as much as 4-8 ft were simulated in the same aquifers at SRS. Results of MODFLOW simulations were analyzed using the USGS particle-tracking code MODPATH to determine the source of water and associated time of travel to VEGP production wells. For each of the scenarios, most of the recharge to VEGP wells originated in an upland area near the county line between Burke and Jefferson Counties, Georgia, with none of the recharge originating on SRS or elsewhere in South Carolina. An exception occurs for the scenario whereby pumping at VEGP was more than tripled. For this scenario, some of the recharge originates in an upland area in eastern Barnwell County, South Carolina. Simulated mean time of travel from recharge areas to VEGP wells for the

  20. Antioxidant, antiproliferative, and pro-apoptotic activities of a saponin extract derived from the roots of Panax notoginseng (Burk.) F.H. Chen.

    PubMed

    He, Nian-Wu; Zhao, Yan; Guo, Ling; Shang, Jun; Yang, Xing-Bin

    2012-04-01

    Dietary and medicinal uses of Panax notoginseng have been associated with reduced risk of cancer. This study was designed to investigate the profiles of P. notoginseng saponin extract (PNSE), the major bioactive ingredients in P. notoginseng (Burk.) F.H. Chen, by high-performance liquid chromatography, and, for the first time, the anticancer effect of PNSE in the human colon cancer cell line LoVo was further evaluated. The major saponins present in PNSE were ginsenosides Rg1 (31.1%) and Rb1 (34.4%), and the total content of the eight saponins identified (notoginsenoside R1, ginsenosides Rg1, Re, Rb1, Rc, and Rd, and isomeric ginsenosides Rb2 and Rb3) was 81.7%, indicating that it was a highly purified standardized saponin extract. Furthermore, PNSE was found to have a markedly cytotoxic effect and antiproliferative activity against the LoVo cell line in a dose- and time-dependent manner. Flow cytometry analysis demonstrated that PNSE caused cell cycle arrest at S phase. Moreover, PNSE was found to possess antioxidative capacities in the 1,1-diphenyl-2-picrylhydrazyl free radical scavenging assay and hydroxyl radical scavenging assay in vitro. Taken together, the present results suggest that naturally occurring PNSE may provide significant natural defense against human colon cancer. PMID:22316295

  1. Regulated expression of the nifM of Azotobacter vinelandii in response to molybdenum and vanadium supplements in Burk's nitrogen-free growth medium.

    PubMed

    Lei, S; Pulakat, L; Gavini, N

    1999-10-14

    Azotobacter is a diazotrophic bacterium that harbors three genetically distinct nitrogenases referred to as nif, vnf, and anf systems. The nifM is an accessory gene located in the nif gene cluster and is transcriptionally regulated by the NifA. However, Azotobacter mutants that lack NifA are known to synthesize functional NifM and this accessory protein is known to be needed for the activity of nitrogenase-2 and nitrogenase-3. To determine how the transcription of nifM is regulated when Azotobacter is grown under conditions in which nitrogenase-2 or nitrogenase-3 is expressed, we generated an Azotobacter vinelandii strain that carries a nifM:lacZ-kanamycin resistance gene cassette in its chromosome. In this strain the nifM open reading frame was disrupted by the presence of a lacZ-kanamycin resistance gene cassette so that it could not produce active NifM. Moreover, the lacZ gene was placed under the transcriptional control elements of the nifM gene so that the lacZ expression could be used as a marker to determine the extent of expression of the nifM gene under different growth conditions. Our results show that this strain was unable to grow in Burk's nitrogen-free medium supplemented with either molybdenum or vanadium or lacking both metals suggesting that in the absence of functional NifM none of the nitrogenases were active. It was also found that the nifM expression was differentially regulated when the A. vinelandii cells were grown under conditions that activate nitrogenase-2 and nitrogenase-3, as determined by liquid beta-galactosidase activity measurements. These results suggest that the transcriptional activators, VnfA and AnfA, may regulate the nifM expression. PMID:10527862

  2. On the phase diagram of water with density functional theory potentials: the melting temperature of Ice I-h with the Perdew-Burke-Ernzerhof and Becke-Lee-Yang-Parr functionals

    SciTech Connect

    Yoo, Soohaeng; Zeng, Xiao Cheng; Xantheas, Sotiris S.

    2009-06-11

    The melting temperature (Tm) of ice Ih was determined from constant enthalphy (NPH) Born-Oppenheimer Molecular Dynamics (BOMD) simulations to be 417±3 K for the Perdew-Burke-Ernzerhof (PBE) and 411±4 K for the Becke-Lee-Yang-Parr (BLYP) density functionals using a coexisting ice (Ih)-liquid phase at constant pressures of P = 2,500 and 10,000 bar and a density ρ = 1 g/cm3, respectively. This suggests that ambient condition simulations at ρ = 1 g/cm3 will rather describe a supercooled state that is overstructured when compared to liquid water. This work was supported by the US Department of Energy Office of Basic Energy Sciences' Chemical Sciences program. Pacific Northwest National Laboratory is operated by Battelle for the US Department of Energy.

  3. Academic Magnet Program at Burke High School.

    ERIC Educational Resources Information Center

    Sklarz, David P.

    A plan for the academic magnet high school (AMHS) program offered by the Charleston County (South Carolina) School District is presented in this report. A program overview describes general goals for students, which would emphasize thinking skills in all academic core areas, problem-solving skills in mathematics and research-based science,…

  4. Burke's Pentad as a Guide for Symbol-Using Citizens

    ERIC Educational Resources Information Center

    Rountree, Clarke; Rountree, John

    2015-01-01

    Ever since the rhetorical turn in education, education scholars have recognized the importance of rhetoric in constructing and mediating human society. They have turned to rhetorical theory to come to terms with this rhetorically mediated reality and to engage students as critical citizens within it. Much of this work draws on rhetorical theorist…

  5. The Role of Burke's Four Master Tropes in Scientific Expression.

    ERIC Educational Resources Information Center

    Tietge, David J.

    1998-01-01

    Outlines the processes behind four master tropes (metaphor, metonymy, synecdoche, and irony) and demonstrates instances where these tropes occur in the expression of scientific concepts. Shows that rhetorical and literary tropes are necessary components to a linguistic understanding of complex scientific concepts; that such tropes are, in fact,…

  6. Systematics of the parasitic wasp genus Oxyscelio Kieffer (Hymenoptera, Platygastridae s.l.), part II: the Australian and southwest Pacific fauna

    PubMed Central

    Burks, Roger A.; Masner, Lubomír; Johnson, Norman F.; Austin, Andrew D.

    2013-01-01

    Abstract The Australasian and southwest Pacific species of Oxyscelio (Hymenoptera: Platygastridae s.l.) are revised. A total of 80 species are recognized as valid, 13 of which are redescribed: O. atricoxa (Dodd), O. concoloripes (Dodd), O. flavipes (Kieffer), O. grandis (Dodd), O. hyalinipennis (Dodd), O. magniclava (Dodd), O. mirellus (Dodd), O. montanus (Dodd), O. nigriclava (Dodd), O. nigricoxa (Dodd), O. rugulosus (Dodd), O. shakespearei (Girault), and O. solitarius (Dodd). Oxyscelio glabriscutellum (Dodd) syn. n. is placed as a subjective junior synonym of O. rugulosus. Sixty-seven new species are described, many representing new distributional records for the genus - O. aciculae Burks, sp. n., O. anfractus Burks, sp. n., O. bellariorum Burks, sp. n., O. bicoloripedis Burks, sp. n., O. brevitas Burks, sp. n., O. catenae Burks, sp. n., O. caudarum Burks, sp. n., O. circulorum Burks, sp. n., O. clivi Burks, sp. n., O. clupei Burks, sp. n., O. conjuncti Burks, sp. n., O. contusionis Burks, sp. n., O. corrugationis Burks, sp. n., O. croci Burks, sp. n., O. cuspidis Burks, sp. n., O. densitatis Burks, sp. n., O. dissimulationis Burks, sp. n., O. divisionis Burks, sp. n., O. exiguitatis Burks, sp. n., O. fluctuum Burks, sp. n., O. foliorum Burks, sp. n., O. funis Burks, sp. n., O. gressus Burks, sp. n., O. hamorum Burks, sp. n., O. incisurae Burks, sp. n., O. lenitatis Burks, sp. n., O. leviventris Burks, sp. n., O. limbi Burks, sp. n., O. liminis Burks, sp. n., O. linguae Burks, sp. n., O. lintris Burks, sp. n., O. livens Burks, sp. n., O. mystacis Burks, sp. n., O. nasi Burks, sp. n., O. nitoris Burks, sp. n., O. obliquiatis Burks, sp. n., O. oblongiclypei Burks, sp. n., O. obturationis Burks, sp. n., O. oculi Burks, sp. n., O. palati Burks, sp. n., O. pectinis Burks, sp. n., O. pollicis Burks, sp. n., O. proceritatis Burks, sp. n., O. productionis Burks, sp. n., O. radii Burks, sp. n., O. rami Burks, sp. n., O. rupturae Burks, sp. n., O. sarcinae Burks, sp. n., O

  7. Planetary Radio Astronomy: The 60 Years from Burke and Franklin to ALMA

    NASA Astrophysics Data System (ADS)

    Steffes, Paul G.

    2014-11-01

    For nearly 60 years, radio astronomy has played a major role in the characterization and monitoring of thermal structure, composition, and temporal changes of the planets and small bodies in our solar system. At this, the 60th anniversary of the initial detection of radio emission by a planet, the role radio astronomy has played in the early characterization of solar system objects, in raising basic scientific questions and motivating planetary exploration missions, and in providing insight into the structure and temporal variations of planets is explored. The evolution of the instrumentation capabilities from crude total-power, or bolometric measurements averaged over an entire planetary disk to today's instrumentation providing radio images of planets and comets with high spectral resolution is also discussed. Major developments such as precise total-power calibration, ultra-large apertures, microwave and millimeter-wave array technology, and supporting laboratory spectroscopy have played major roles in enhancing the effectiveness of radio astronomical observations. The newest generation instruments such as the upgraded Jansky Very Large Array (VLA) and the Altacama Large Millimeter Array (ALMA) now usher in a whole new level of capability in observation of solar system objects.

  8. 75 FR 14467 - Notice of Inventory Completion: Pierce College District, Lakewood, WA, and Thomas Burke Memorial...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-25

    ... National Park Service Notice of Inventory Completion: Pierce College District, Lakewood, WA, and Thomas... in the control of the Pierce College District, Lakewood, WA, and in the physical custody of the... Assistant Director of Facilities, Pierce College District, 9401 Farwest Dr. SW, Lakewood, WA...

  9. 78 FR 59955 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-30

    ... removes a paragraph from a Notice of Inventory Completion published in the Federal Register (78 FR 45958... correction notice has not occurred. Correction In the Federal Register (78 FR 45958-45960, July 30, 2013), paragraph 12 is removed in its entirety. In the Federal Register (78 FR 45958-45960, July 30,...

  10. 78 FR 44595 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-24

    ...: Notice is here given in accordance with the Native American Graves Protection and Repatriation Act... control of the Native American human remains and associated funerary objects. The National Park Service is... Counties, WA. The human remains in this notice have been determined to be Native American based...

  11. 77 FR 59649 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-28

    ... Orcas Island was one of the primary areas occupied by the Swallah, who later joined the Lummi (Ruby and..., while Spier indicated that the Swallah occupied the area. The Swallah later joined the Lummi (Ruby...

  12. 78 FR 64006 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-25

    ... were included in a Notice of Inventory Completion published in the Federal Register (78 FR 45958-45959... heritage to southern Whidbey Island. Historical and anthropological sources (Mooney 1896, Ruby and...

  13. 75 FR 52023 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-24

    ... area surrounding Salem, OR, was occupied by the Kalapuyan speaking people (Ruby and Brown 1986, Swanton... 1855, the Kalapuyan people were moved to the Grand Ronde Reservation (Ruby and Brown 1986)....

  14. 75 FR 436 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-05

    ... remains were discovered with cedar bark over them during construction of the Denny Regrade, and collected... of Salish cultures. The Duwamish people primarily occupied this area (Ruby and Brown 1986:72). As per... Brown 1986, Suttles and Lane 1990, Swanton 1952). The Sammamish people were closely related to...

  15. 75 FR 5105 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-01

    ... flakes; 5 unmodified stones; 1 bone bipoint; 1 bone tool; 1 bone tube; 5 charcoal samples; 1 core; 1 dog... containing stone, charcoal, shell, mammal, fish, and bird bones. The Watmough Bay archeological site is...

  16. 78 FR 45958 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-30

    ... identified in this notice that wish to request transfer of control of these human remains and associated... forward, transfer of control of the human remains and associated funerary objects to the lineal... notice that wish to request transfer of control of these human remains and associated funerary...

  17. 78 FR 50109 - Notice of Intent To Repatriate Cultural Items: Thomas Burke Memorial Washington State Museum...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-16

    ... Native American Graves Protection and Repatriation Act (NAGPRA), 25 U.S.C. 3005, of the intent to... Native American cultural items. The National Park Service is not responsible for the determinations in... in style with Native American Coast Salish historic material culture. Linguistically, Native...

  18. 78 FR 50443 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-19

    ... INFORMATION: Notice is here given in accordance with the Native American Graves Protection and Repatriation... Native American human remains and associated funerary objects. The National Park Service is not... archaeological sites. The human remains in this notice have been determined to be Native American based...

  19. 78 FR 59956 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-30

    ... deleonl@cwu.edu . SUPPLEMENTARY INFORMATION: Notice is here given in accordance with the Native American... agency that has control of the Native American human remains. The National Park Service is not... have been determined to be Native American based on biological and archeological evidence. The...

  20. 78 FR 59963 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-30

    ... deleonl@cwu.edu . SUPPLEMENTARY INFORMATION: Notice is here given in accordance with the Native American... agency that has control of the Native American human remains. The National Park Service is not... been determined to be Native American based on a variety of sources, including archeological...

  1. 78 FR 59964 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-30

    ... here given in accordance with the Native American Graves Protection and Repatriation Act (NAGPRA), 25 U... museum, institution, or Federal agency that has control of the Native American human remains. The... associated funerary objects are present. Based on cranial morphology, the human remains are Native...

  2. "Making Waves" with Burke: Surf Nazi Culture and the Rhetoric of Localism.

    ERIC Educational Resources Information Center

    Scheibel, Dean

    1995-01-01

    Describes the historical, cultural, and mythic contexts that infuse the territorial exclusionary practices of surfers. Analyzes surfers' rhetorical responses in letters published in surfing magazines, describing how rhetors use economic and religious metaphors to position ideologies that both reproduce and mediate cultural myths of perfection…

  3. 77 FR 46117 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-02

    ...; Port Gamble Indian Community of the Port Gamble Reservation, Washington; Puyallup Tribe of the Puyallup... Idaho); Nooksack Indian Tribe of Washington; Port Gamble Indian Community of the Port Gamble...

  4. 78 FR 11675 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-19

    ... Tribe of the Makah Indian Reservation; Port Gamble Band of S'Klallam Indians (previously listed as Port Gamble Indian Community of the Port Gamble Reservation, Washington); Quileute Tribe of the Quileute...; Port Gamble Band of S'Klallam Indians (previously listed as Port Gamble Indian Community of the...

  5. Systematics of the parasitic wasp genus Oxyscelio Kieffer (Hymenoptera, Platygastridae s.l.), Part I: Indo-Malayan and Palearctic fauna

    PubMed Central

    Burks, Roger A.; Masner, Lubomír; Johnson, Norman F.; Austin, Andrew D.

    2013-01-01

    Abstract The Indo-Malayan and Palearctic species of Oxyscelio (Hymenoptera: Platygastridae s.l.) are revised. A total of 90 species are recognized as valid, 19 of which are redescribed - Oxyscelio acutiventris (Kieffer), Oxyscelio brevinervis (Kieffer), Oxyscelio carinatus (Kieffer), Oxyscelio ceylonensis (Dodd), Oxyscelio consobrinus (Kieffer), Oxyscelio crassicornis (Kieffer), Oxyscelio cupularis (Kieffer), Oxyscelio dorsalis (Kieffer), Oxyscelio excavatus (Kieffer), Oxyscelio flavipennis (Kieffer), Oxyscelio florus Kononova, Oxyscelio foveatus Kieffer, Oxyscelio kiefferi Dodd, Oxyscelio magnus (Kieffer), Oxyscelio marginalis (Kieffer), Oxyscelio naraws Kozlov & Lê, Oxyscelio perpensus Kononova, Oxyscelio rugosus (Kieffer) and Oxyscelio spinosiceps (Kieffer), and 71 which are described as new - Oxyscelio aclavae Burks, sp. n., Oxyscelio amrichae Burks, sp. n., Oxyscelio anguli Burks, sp. n., Oxyscelio angustifrons Burks, sp. n., Oxyscelio angustinubbin Burks, sp. n., Oxyscelio arcus Burks, sp. n., Oxyscelio arvi Burks, sp. n., Oxyscelio asperi Burks, sp. n., Oxyscelio aureamediocritas Burks, sp. n., Oxyscelio bipunctuum Burks, sp. n., Oxyscelio brevidentis Burks, sp. n., Oxyscelio caesitas Burks, sp. n., Oxyscelio capilli Burks, sp. n., Oxyscelio capitis Burks, sp. n., Oxyscelio cavinetrion Burks, sp. n., Oxyscelio chimaerae Burks, sp. n., Oxyscelio codae Burks, sp. n., Oxyscelio convergens Burks, sp. n., Oxyscelio cordis Burks, sp. n., Oxyscelio crateris Burks, sp. n., Oxyscelio crebritas Burks, sp. n., Oxyscelio crustum Burks, sp. n., Oxyscelio cuculli Burks, sp. n., Oxyscelio cyrtomesos Burks, sp. n., Oxyscelio dasymesos Burks, sp. n., Oxyscelio dasynoton Burks, sp. n., Oxyscelio dermatoglyphes Burks, sp. n., Oxyscelio doumao Burks, sp. n., Oxyscelio fistulae Burks, sp. n., Oxyscelio flabellae Burks, sp. n., Oxyscelio flaviventris Burks, sp. n., Oxyscelio fodiens Burks, sp. n., Oxyscelio fossarum Burks, sp. n., Oxyscelio fossularum Burks, sp. n., Oxyscelio

  6. "Extraordinary Understandings" of Composition at the University of Chicago: Frederick Champion Ward, Kenneth Burke, and Henry W. Sams

    ERIC Educational Resources Information Center

    Beasley, James P.

    2007-01-01

    While Richard Weaver, R. S. Crane, Richard McKeon, and Robert Streeter have been most identified with rhetoric at the University of Chicago and its institutional return in the 1950s, the archival record demonstrates that Frederick Champion Ward, dean of the undergraduate "College" from 1947 to 1954, and Henry W. Sams, director of English in the…

  7. Systematics of the parasitic wasp genus Oxyscelio Kieffer (Hymenoptera, Platygastridae s.l.), part III: African fauna

    PubMed Central

    Burks, Roger A.; Masner, Lubomír; Johnson, Norman F.; Austin, Andrew D.

    2016-01-01

    Abstract African species of Oxyscelio (Hymenoptera: Platygastridae s.l.) are revised. A total of 14 species are recognized, 13 of which are described as new: Oxyscelio absentiae Burks, sp. n., Oxyscelio galeri Burks, sp. n., Oxyscelio gyri Burks, sp. n., Oxyscelio idoli Burks, sp. n., Oxyscelio intensionis Burks, sp. n., Oxyscelio io Burks, sp. n., Oxyscelio kylix Burks, sp. n., Oxyscelio lunae Burks, sp. n., Oxyscelio nemesis Burks, sp. n., Oxyscelio pulveris Burks, sp. n., Oxyscelio quassus Burks, sp. n., Oxyscelio teli Burks, sp. n. and Oxyscelio xenii Burks, sp. n. The genus Freniger Szabó, syn. n. is recognized as part of an endemic African species group of Oxyscelio with incomplete hind wing venation, and Oxyscelio bicolor (Szabó), comb. n. is therefore recognized as the only previously described species of Oxyscelio from Africa. The Oxyscelio crateris and Oxyscelio cuculli species groups, previously known from southeast Asia, are represented in Africa by seven and one species respectively. PMID:27081336

  8. Novacon process: An alternative to limestone sorbents. Presentation to the Council of Industrial Boiler Owners, fluid bed XI. Held in Burke, Virginia, on November 14, 1995

    SciTech Connect

    Baer, S.H.; Luftglass, B.K.

    1995-12-31

    This paper presents the results of recent tests of a new type of sorbent useful for emissions control. The sorbent, referred to as thermally active marble (TAM), comprises a class of naturally-occurring metamorphic calcium carbonates. TAMs break down upon heating in combustors more evenly and with higher reactivity than limestone, resulting in better calcium utilization rates. Use of TAMS may also reduce NOx and CO emissions, excess air consumption and unburned carbon, and also improve combustion efficiency. In a full-scale (90 MW) demonstration comparing TAM to limestone, the Ca/S improved from 2.6 to 1.5 or better. Unburned carbon in fly ash decreased significantly and NOx levels were also reduced.

  9. Determination of aerosol content in the atmosphere from LANDSAT data. [San Diego, Salton Sea, Miami, Adrigole, Atlantic City, Barrow, and Burke, Divide, Hill, and Toole Counties

    NASA Technical Reports Server (NTRS)

    Griggs, M. (Principal Investigator)

    1978-01-01

    The author has identified the following significant results. A large set of LANDSAT 2 data, obtained at San Diego, showed excellent linear relationships, particularly for MSS 5 and MSS 6, between the radiance over the ocean and the atmospheric aerosol content. Two other data points obtained at Adrigole, Ireland, representing a different ocean and a different ground truth instrument, showed very good agreement with the San Diego data. It appeared that the technique could be used for global monitoring of the atmospheric aerosol content over the oceans. Results obtained at several inland bodies of water showed that MSS 4, MSS 5, and MSS 6 cannot be used due to the effect of water pollution generally present. However, the LANDSAT 1 results suggested that MSS 7, which operates at longer wavelengths, was not very sensitive to water pollution, and might be useful for inland measurements of aerosol content. Use of the longer wavelength would also minimize the effects of adjacent high albedo land, since atmospheric scattering was reduced at longer wavelengths.

  10. The influence of barometric pressure fluctuations, earth tides and rainfall loading on fluid pressures in coastal plain aquifers, Burke County, Georgia

    SciTech Connect

    Benson, S.M.; Moore, J.; Daggett, J.; Snipes, D.S. . Dept. of Earth Sciences)

    1993-03-01

    High precision pressure measurements from several aquifers in the top 225 m of coastal plain sediments reveal that barometric pressure fluctuations, earth tides and rainfall loading create pressure fluctuations on the order of tens of centimeters. If not correctly identified, erroneous conclusions regarding the magnitude of pressure communication within and across aquifers during pumping tests may be inferred. Aquifer pressure data with an equivalent resolution of 0.1 mm change in water level were measured in 4 wells over a 10 day period at the USGS Miller's Pond Test Site. During this time, barometric pressures fluctuated by the equivalent of 20 cm of water. Aquifer pressures mimicked these changes, with corresponding barometric efficiencies ranging from 0.59 for the deepest well (215 to 224 m) to 0.73 for the shallowest (136 to 145 m). After removing barometric influences from the pressure data, periodic pressure fluctuations of 2 cm were observed. These correlate well with fluctuations in the earths gravitational field created by planetary motion. A twelve component earth tide model was used to calculate the magnitude of the gravitational fluctuations and provide a quantitative basis for comparing them to observed aquifer pressure fluctuations. Additionally, three rainfall events caused rapid and relatively large increases in aquifer pressures. Up to 4 cm increase in the aquifer pressure accompanied the heaviest rains. The pressures increased concurrent to the rains and decayed slowly to background levels over a several day period, indicating a loading response instead of an infiltration induced pressure increase. The relatively large magnitude of these influences, compared to the small changes induced by leakage across confining layers requires careful consideration in the data analysis.

  11. 75 FR 14462 - Notice of Inventory Completion: Central Washington University, Department of Anthropology...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-25

    ... Anthropology, Ellensburg, WA, and Thomas Burke Memorial Washington State Museum, University of Washington... of Anthropology, Ellensburg, WA, and the Thomas Burke Memorial Washington State Museum (Burke Museum... Henebry-DeLeon, NAGPRA Program Director, Department of Anthropology, Central Washington...

  12. Four new species of Cymatodera Gray from central and southern Mexico (Coleoptera, Cleridae, Tillinae)

    PubMed Central

    Burke, Alan F.; Rifkind, Jacques; Zolnerowich, Gregory

    2015-01-01

    Abstract Four new species of Cymatodera are described from Mexico: Cymatodera tortuosa Burke & Rifkind, sp. n. from Hidalgo and Tamaulipas; Cymatodera ortegae Burke, sp. n. from Colima, Jalisco and Michoacan; Cymatodera gerstmeieri Burke & Rifkind, sp. n. from Chiapas; and Cymatodera mixteca Burke & Rifkind, sp. n. from Puebla and Guerrero. Male genitalia and other characters of taxonomic value are illustrated. PMID:26257571

  13. A Burkean Perspective of Romantic Jealousy.

    ERIC Educational Resources Information Center

    Byers, Peggy Yuhas

    Kenneth Burke's dramatistic theory of social movements can be applied to current romantic jealousy theories. Burke's dramaturgy has seven major elements: order, guilt, negation, victimage, mortification, catharsis, and redemption. These elements may all be transposed onto Burke's three critical motives: Order (status quo), Secret (differences…

  14. Comments on: Chari, R.; Burke, T.A.; White, R.H.; Fox, M.A. Integrating Susceptibility into Environmental Policy: An Analysis of the National Ambient Air Quality Standard for Lead. Int. J. Environ. Res. Public Health 2012, 9, 1077–1096

    PubMed Central

    Bowers, Teresa S.

    2013-01-01

    A recent publication in International Journal of Environmental Research and Public Health by Chari et al. [1] provides no basis for changing the National Ambient Air Quality Standard (NAAQS) for lead in the U.S. to protect children in low socio-economic (SES) populations. The studies selected by Chari et al. for analysis do not provide comparable information on regression coefficients for the blood lead level-IQ relationship. The coefficients differ from one another more on the basis of unequal blood lead metrics, ages of blood lead measurement, and differences in covariate adjustments and standardization, than the difference postulated by Chari et al. to correspond to low vs. high SES populations. PMID:23429754

  15. Comments on: Chari, R.; Burke, T.A.; White, R.H.; Fox, M.A. Integrating Susceptibility into environmental policy: an analysis of the national ambient air quality standard for lead. Int. J. Environ. Res. Public Health 2012, 9, 1077-1096.

    PubMed

    Murphy, Deirdre L; Patel, Molini; Kirrane, Ellen; Vinikoor-Imler, Lisa

    2013-02-01

    In their recent article [1], Chari et al. call attention to the important subject of setting National Ambient Air Quality Standards (NAAQS) to provide requisite protection for public health, including the health of sensitive groups, as specified under the Clean Air Act (73 FR 66965) [2]. The authors focus on consideration of susceptibility to inform policy choices, using lead (Pb)-related neurocognitive effects and children from low socioeconomic status (SES) families in the context of alternative Pb standard levels. Our comments focus on the authors' analysis of the scientific evidence and not on policy. We agree with the authors that the health effects evidence for Pb indicates a role (or roles) for SES-related factors in influencing childhood Pb exposure and associated health effects. We disagree, however, with the authors' interpretation of the literature on SES influence on the shape of the concentration-response (C-R) relationship between children's blood Pb and IQ (e.g., steepness of the slope). We further address aspects of the scientific evidence that are important to the consideration of sensitive populations in the context of the Pb NAAQS, and how the U.S. Environmental Protection Agency (EPA) considered this evidence in setting the Pb NAAQS in 2008. PMID:23396080

  16. Courting the Buyer: The Relationship of Newspaper, Audience, and Advertisers.

    ERIC Educational Resources Information Center

    Thompson, Timothy N.

    By applying Kenneth Burke's concepts of Order, the Secret, and the Kill to the newspaper-audience-advertiser relationship, the narrow imagery that depicts that relationship only in economic terms can be counteracted. Burke's maps of hierarchy, mystery, and transcendence in human action allow the depiction of a complex meshing of patterns,…

  17. 75 FR 28664 - Southern Nuclear Operating Company; Notice of Availability of Environmental Assessment and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-21

    ... Operating Company et al., for Vogtle Electric Generating Plant ESP Site Located in Burke County, GA AGENCY... the proposed change was previously noticed in the Federal Register on May 6, 2010 (75 FR 24993), with... Electric Generating Plant (VEGP) ESP site located in Burke County, Georgia. The proposed amendment...

  18. New Attitudes Shaping Labor-District Relations

    ERIC Educational Resources Information Center

    Sawchuk, Stephen

    2012-01-01

    Back in the mid-2000s, in public and in the news media, Joseph P. Burke, then superintendent of the Springfield public schools, and Timothy T. Collins, president of the local teachers' union, often seemed to be at odds with each other. Out of the public eye, however, the two men had begun meeting regularly. When Burke left the district, the work…

  19. Form in Technique: Counter-Nature's "Invitation To Participate" and the Ethics of Ecology.

    ERIC Educational Resources Information Center

    Muir, Star A.

    This paper examines the rhetorician Kenneth Burke's reaction to "technologism," an area where Burke's rage at the vagaries of human motivation, industrial exploitation, and environmental victimage are most clear. The paper analyzes in-depth the formal movement of the Helhaven project as a reflexive satirical treatment of the problems of…

  20. Voluntary Teacher Leadership: Key to Sustainable Improvement

    ERIC Educational Resources Information Center

    Hickman, Wayne A.; Moore, Lynda C.; Torek, Tonya J.

    2008-01-01

    When the Burke County Board of Education mandated Burke County High School in Waynesboro, Georgia to "seek a solution" to its poor graduation rate--specifically, to change the school's schedule, teachers were given the responsibility and authority to plan and facilitate the transition. The transition process taught teachers and administrators that…

  1. Burkeian and Freudian Theories of Identification.

    ERIC Educational Resources Information Center

    Wright, Mark H.

    1994-01-01

    Argues that Kenneth Burke made advances in adapting two of Freud's processes of identification for the analysis of public communication, but that Burke's reading of Freud on identification in groups submerges important conceptual aspects. Discusses the consequences to rhetorical criticism (and to those studying small group ties within…

  2. The Role of Testing Language Proficiency as Part of Teacher Certification

    ERIC Educational Resources Information Center

    Aoki, Michele Anciaux

    2013-01-01

    Bridid M. Burke poses an interesting question: Is requiring high-stakes language proficiency tests really going to improve world language education? In her article, Dr. Burke shares testimonials from "several promising student teachers" [whose] dreams of being French, German, or Spanish teachers [were] crushed" based on not…

  3. A Dramatistic Theory of Apocalyptic Rhetoric.

    ERIC Educational Resources Information Center

    O'Leary, Stephen D.

    1993-01-01

    Develops a theory of apocalyptic texts and movements by applying Kenneth Burke's conception of the tragic and comic frames of acceptance to the text of the Christian Apocalypse and to the history of its interpretation. Uses Burke's "psychology of form" to explain the recurring patterns of apocalyptic argument as functions of rhetoric/audience…

  4. [Environmental Education Experiences].

    ERIC Educational Resources Information Center

    Burke County Board of Education, Morganton, NC.

    Environmental/ecological experiences, appropriate for elementary grades, are presented in this compilation. Designed as individual units of study, they consider components of the natural environment and in particular the local environment of Burke County, North Carolina. Units are titled: Burke County in a Nutshell, Our Culture, A Tour of the…

  5. Reconciling disagreement over climate–conflict results in Africa

    PubMed Central

    Hsiang, Solomon M.; Meng, Kyle C.

    2014-01-01

    A recent study by Burke et al. [Burke M, Miguel E, Satyanath S, Dykema J, Lobell D (2009) Proc Natl Acad Sci USA 106(49):20670–20674] reports statistical evidence that the likelihood of civil wars in African countries was elevated in hotter years. A following study by Buhaug [Buhaug H (2010) Proc Natl Acad Sci USA 107(38):16477–16482] reports that a reexamination of the evidence overturns Burke et al.’s findings when alternative statistical models and alternative measures of conflict are used. We show that the conclusion by Buhaug is based on absent or incorrect statistical tests, both in model selection and in the comparison of results with Burke et al. When we implement the correct tests, we find there is no evidence presented in Buhaug that rejects the original results of Burke et al. PMID:24520173

  6. Asthma - quick-relief drugs

    MedlinePlus

    ... Burks AW, et al., eds. In: Middleton's Allergy Principles and Practice . 8th ed. Philadelphia, PA: Elsevier Mosby; 2013:chap 55. Guidelines for the Diagnosis and Management of Asthma . Rockville, MD. National Heart, Lung, and ...

  7. Nasal polyps

    MedlinePlus

    ... BS, Burks AW, et al, eds. Middleton's Allergy: Principles and Practice . 8th ed. Philadelphia, PA: Elsevier Saunders; 2014:chap 43. Becker SS. Surgical management of polyps in the treatment of nasal airway ...

  8. Asthma - control drugs

    MedlinePlus

    ... Burks AW, et al., eds. In: Middleton's Allergy Principles and Practice . 8th ed. Philadelphia, PA: Elsevier Mosby; 2013:chap 55. Guidelines for the Diagnosis and Management of Asthma . Rockville, MD. National Heart, Lung, and ...

  9. 78 FR 21411 - National Register of Historic Places; Notification of Pending Nominations and Related Actions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-10

    ... Fulton County Goodrum, May Patterson, House, 320 West Paces Ferry Rd., NW., Atlanta, 13000215 KANSAS Ford... County Lowe, Robert Chester and Elsie H., House, 1010 Shawneehaw Ave., Banner Elk, 13000226 Burke...

  10. The Ideological Turn in Modern Criticism.

    ERIC Educational Resources Information Center

    Wander, Philip

    1983-01-01

    Discusses the nature and purpose of rhetorical criticism within academic, political, and historical contexts. Traces some of the ideological forces underlying twentieth century criticism. Considers the works of Herbert Wichelns, Kenneth Burke, Forbes Hill, Lawrence Rosenfield, and Martin Heidegger. (PD)

  11. How to use a nebulizer

    MedlinePlus

    Laube BL, Dolovich MB. Aerosols and aerosol drug delivery systems. In: Adkinson NF Jr, Bochner BS, Burks AW, et al, eds. Middleton's Allergy Principles and Practice . 8th ed. Philadelphia, PA: Elsevier ...

  12. How to use an inhaler - with spacer

    MedlinePlus

    Laube BL, Dolovich MB. Aerosols and aerosol drug delivery systems. In: Adkinson NF Jr, Bochner BS, Burks AW, et al, eds. Middleton's Allergy Principles and Practice . 8th ed. Philadelphia, PA: Elsevier ...

  13. How to use an inhaler - no spacer

    MedlinePlus

    Laube BL, Dolovich MB. Aerosols and aerosol drug delivery systems. In: Adkinson NF Jr, Bochner BS, Burks AW, et al, eds. Middleton's Allergy Principles and Practice . 8th ed. Philadelphia, PA: Elsevier ...

  14. Perfection and the Bomb: Nuclear Weapons, Teleology, and Motives.

    ERIC Educational Resources Information Center

    Brummett, Barry

    1989-01-01

    Uses Kenneth Burke's theory of perfection to explore the vocabularies of nuclear weapons in United States public discourse and how "the Bomb" as a God term has gained imbalanced ascendancy in centers of power. (MS)

  15. Sneezing

    MedlinePlus

    ... J, Baroody FM, Pawankar R. Allergic and nonallergic rhinitis. In: Adkinson NF Jr., Bochner BS, Burks AW, ... Elsevier Saunders; 2011:chap 257. Patient Instructions Allergic rhinitis - what to ask your doctor - adult Allergic rhinitis - ...

  16. OHIO INTERNATIONAL TELEVISION AND VIDEO FESTIVAL AWARD WINNERS FROM THE IMAGING TECHNOLOGY CENTER IT

    NASA Technical Reports Server (NTRS)

    2000-01-01

    OHIO INTERNATIONAL TELEVISION AND VIDEO FESTIVAL AWARD WINNERS FROM THE IMAGING TECHNOLOGY CENTER ITC KEVIN BURKE - BILL FLETCHER - GARY NOLAN - EMERY ADANICH FOR THE VIDEO ENTITLED ICING FOR REGIONAL AND CORPORATE PILOTS

  17. Experiential Professional Development: A Model for Meaningful and Long-Lasting Change in Classrooms

    ERIC Educational Resources Information Center

    Burke, Brigid M.

    2013-01-01

    An experiential approach to professional development (EPD) allowed Spanish teachers opportunities to improve their practice through demonstration, observation, collaboration, fieldwork, and reflection. As result of "experiential" professional development, Burke (2012) found that teachers' knowledge about communicative language teaching…

  18. 76 FR 35396 - Notice of Intent To Reestablish the National Genetic Resources Advisory Council, and Request for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-17

    ... INFORMATION CONTACT: J. Robert Burk, 202-720-3684. Correction In the Federal Register of May 14, 2011, in FR... Request for Nominations. SUMMARY: The notice announced USD intent to reestablish the National...

  19. Comment on Turbulent Equipartition Theory of Toroidal Momentum Pinch

    SciTech Connect

    Hahm, T. S.; Diamond, P. H.; Gurcan, O. D.; Rewoldt, G.

    2009-03-12

    This response demonstrates that the comment by Peeters et al. contains an incorrect and misleading interpretation of our paper [Hahm et al., Phys. Plasmas 15, 055902 (2008)] regarding the density gradient dependence of momentum pinch and the turbulent equipartition (TEP) theory.

  20. The Cartographic Representation of Linguistic Data. Discussion Papers in Geolinguistics Nos. 19-21. Selected Papers from a Geolinguistic Seminar (Le Pailly, France, September 10-13, 1992).

    ERIC Educational Resources Information Center

    Peeters, Yvo J. D., Ed.; Williams, Colin H., Ed.

    Papers from a conference on cartography in geolinguistics include: "The Political Importance of Visualisation of Language Contact" (Yvo J. D. Peeters); "Some Considerations on People and Boundaries" (Guy Heraud); "Geolinguistic Developments and Cartographic Problems" (Colin H. Williams, John E. Ambrose); "A Conceptual Home for Geolinguistics:…

  1. Book Reviews.

    ERIC Educational Resources Information Center

    International Journal of Early Childhood, 1994

    1994-01-01

    Reviews "La Educacion Preescolar: Desafio y Aventura" (Lavanchy Bobsien); "Working towards Better Childcare" (Peeters and Vandenbroeck, editors); "Children's Savings: A Study in the Development of Economic Behavior" (Sonuga-Barke and Webley); "Curvas de Crecimiento Estaturo-ponderal en Escolares" (Saez Crespo and others); and "Helping Bereaved…

  2. "Build Me a Male Role Model!" A Critical Exploration of the Perceived Qualities/Characteristics of Men in the Early Years (0-8) in England

    ERIC Educational Resources Information Center

    Brownhill, Simon

    2014-01-01

    Young boys' "underachievement" and their disaffection with learning continue to dominate education agendas [Francis, B. 2006. "Stop That Sex Drive." "Times Educational Supplement" 30; Peeters, J. 2007. "Including Men in Early Childhood Education: Insights from the European Experience." "NZ Research…

  3. Science Is Art

    NASA Astrophysics Data System (ADS)

    Burke, Michael

    2010-03-01

    Michael Burke is an artist who's work combines scientific principles with aesthetic goals. He will describe how he became an artist after careers in astronomy and city planning, and discuss the supposed separation of science and art. The talk will be illustrated with photographs of his work, including an installation in an Etruscan tomb and one at the port city of Savona in Italy. Mr. Burke sees a romance in science equivalent to that of art, and will argue that the two should not be so resolutely separated.

  4. A Multiscale Model Based On Intragranular Microstructure: Influence Of Grain-Scale Substructure On Macroscopic Behaviour Of An IF-Steel During Complex Load Paths

    SciTech Connect

    Franz, Gerald; Abed-Meraim, Farid; Berveiller, Marcel; Zineb, Tarak Ben; Lemoine, Xavier

    2007-05-17

    A microstructural model, based on Peeters' works, is implemented into a large strain self-consistent scheme, leading to the multiscale model which achieves, for each grain, the calculation of slip activity, with help of regularized formulation drawn from the visco-plasticity framework, and the dislocation microstructure evolution. This paper focuses on the relationship between macroscopic hardening/softening effects and induced microstructure during monotonic and two-stage strain paths.

  5. A Multiscale Model Based On Intragranular Microstructure: Influence Of Grain-Scale Substructure On Macroscopic Behaviour Of An IF-Steel During Complex Load Paths

    NASA Astrophysics Data System (ADS)

    Franz, Gérald; Abed-Meraim, Farid; Zineb, Tarak Ben; Lemoine, Xavier; Berveiller, Marcel

    2007-05-01

    A microstructural model, based on Peeters' works, is implemented into a large strain self-consistent scheme, leading to the multiscale model which achieves, for each grain, the calculation of slip activity, with help of regularized formulation drawn from the visco-plasticity framework, and the dislocation microstructure evolution. This paper focuses on the relationship between macroscopic hardening/softening effects and induced microstructure during monotonic and two-stage strain paths.

  6. The 1984 Campaign Rhetoric of Representative George Hansen: A Pentadic Analysis.

    ERIC Educational Resources Information Center

    Kelley, Colleen E.

    1987-01-01

    Employs Kenneth Burke's pentad to examine rhetorical choices made by former U.S. Congressman George Hansen as he dramatized two situations: his felony conviction and his subsequent reelection bid. Suggests that Hansen's rhetoric was largely effective because it resulted in substantial identification with the voters of Idaho's Second Congressional…

  7. Beyond Strategy: A Reader-Centered Analysis of Irony's Dual Persuasive Uses

    ERIC Educational Resources Information Center

    Olson, Kathryn M.; Olson, Clark D.

    2004-01-01

    Ironic texts offer pleasure both as what Burke called "ordinary" and "pure persuasion." Readers may engage these symbolic dimensions simultaneously, but in different relative proportions. Using the coincidence of the 1986 sentencing of sanctuary movement members and the rededication of the Statue of Liberty, we offer four possible interpretive…

  8. Rating Scales for Dystonia in Cerebral Palsy: Reliability and Validity

    ERIC Educational Resources Information Center

    Monbaliu, E.; Ortibus, E.; Roelens, F.; Desloovere, K.; Deklerck, J.; Prinzie, P.; De Cock, P.; Feys, H.

    2010-01-01

    Aim: This study investigated the reliability and validity of the Barry-Albright Dystonia Scale (BADS), the Burke-Fahn-Marsden Movement Scale (BFMMS), and the Unified Dystonia Rating Scale (UDRS) in patients with bilateral dystonic cerebral palsy (CP). Method: Three raters independently scored videotapes of 10 patients (five males, five females;…

  9. 78 FR 49551 - Vogtle Electric Generating Station, Units 3 and 4; Southern Nuclear Operating Company; Change to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-14

    ... 11, 2012 (77 FR 73684). The supplements had no effect on the no significant hazards consideration...), Units 3 and 4, located in Burke County, Georgia. The amendment requests to revise the structure and... of the Turbine Building due to revising the structure and layout of the building. Tier 1...

  10. Job Satisfaction among High School Athletic Administrators

    ERIC Educational Resources Information Center

    Green, Gregory; Reese, Shirley A.

    2006-01-01

    Coaching and supervising high school sport programs can be a rewarding, but stressful career. Many researchers have identified a close relationship between occupational stress and job satisfaction, or how one feels about the job (Burke 1971; Buck, 1972; Howard, 1978). Most studies of job satisfaction in education have tended to focus on teachers.…

  11. A Multidisciplinary Approach to Literacy through Picture Books and Drama

    ERIC Educational Resources Information Center

    Burke, Anne; Peterson, Shelley Stagg

    2007-01-01

    Anne Burke and Shelley Stagg Peterson argue that "picture books offer a medium for teaching visual and critical literacy across the curriculum." To support this idea, they describe a multidisciplinary unit on World War II that pushes high school students to utilize visual and print literacies to analyze, comprehend, and relate to public events and…

  12. Psychosocial Interventions for School Refusal Behavior with Primary and Secondary School Students: A Campbell Systematic Review and Meta-Analysis

    ERIC Educational Resources Information Center

    Maynard, Brandy R.; Brendel, Kristen E.; Bulanda, Jeffery J; Thompson, Aaron M.; Pigott, Terri D.

    2015-01-01

    School refusal behavior, affecting between 1% and 5% of school-age children, is a psychosocial problem for students characterized by severe emotional distress and anxiety at the prospect of going to school, leading to difficulties in attending school and, in some cases, significant absences from school (Burke & Silverman, 1987; Elliot, 1999;…

  13. Ethical and Spiritual Values in Counseling.

    ERIC Educational Resources Information Center

    Burke, Mary Thomas, Ed.; Miranti, Judith G., Ed.

    This book presents a compilation of articles previously published in the journal "Counseling and Values." The follwing articles are included: (1) "Ethics and Spirituality: The Prevailing Forces Influencing the Counseling Profession" (Judith Miranti, Mary Thomas Burke); (2) "Three Contributions of a Spiritual Perspective to Counseling,…

  14. Asthma

    MedlinePlus

    ... Burks AW, et al, eds. In: Middleton's Allergy Principles and Practice . 8th ed. Philadelphia, PA: Elsevier Mosby; 2014:chap 55. Lugogo N, Que LG, Gilstrap DL, Kraft M. Asthma: clinical diagnosis and management. In: Broaddus VC, Mason RJ, Ernst JD, et ...

  15. Asthma - children

    MedlinePlus

    ... BS, Burks AW, et al, eds. Middleton's Allergy Principles and Practice . 8th ed. Philadelphia, PA: Elsevier Mosby; 2014:chap 53. Lugogo N, Que LG, Gilstrap DL, Kraft M. Asthma: clinical diagnosis and management. In: Broaddus VC, Mason RJ, Ernst JD, et ...

  16. The Gothic Voice in Eighteenth-Century Oratory.

    ERIC Educational Resources Information Center

    Browne, Stephen H.

    1988-01-01

    Cites evidence of Gothic strains in eighteenth-century rhetorical practice. Uses a narrative account by Edmund Burke to illustrate representative Gothic themes, images, and strategies. Judges the Gothic voice to be significant as an instance of the ways in which general aesthetic sensibilities are deployed for rhetorical ends. (MS)

  17. 76 FR 14699 - Southern Nuclear Operating Company; Notice of Availability of Application for a Combined License

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-17

    ... Generating Plant (VEGP) site located in Burke County, Georgia. The reactors are to be identified as VEGP... On March 28, 2008, Southern Nuclear Operating Company (SNC), acting on behalf of itself and Georgia... Authority of Georgia, and the City of Dalton, Georgia, an incorporated municipality in the State of...

  18. 76 FR 16645 - Southern Nuclear Operating Company; Notice of Availability of Application for a Combined License

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-24

    ... Generating Plant (VEGP) site located in Burke County, Georgia. The reactors are to be identified as VEGP... On March 28, 2008, Southern Nuclear Operating Company (SNC), acting on behalf of itself and Georgia... Authority of Georgia, and the City of Dalton, Georgia, an incorporated municipality in the State of...

  19. Researcher Effects on Mortality Salience Research: A Meta-Analytic Moderator Analysis

    ERIC Educational Resources Information Center

    Yen, Chih-Long; Cheng, Chung-Ping

    2013-01-01

    A recent meta-analysis of 164 terror management theory (TMT) papers indicated that mortality salience (MS) yields substantial effects (r = 0.35) on worldview and self-esteem-related dependent variables (B. L. Burke, A. Martens, & E. H. Faucher, 2010). This study reanalyzed the data to explore the researcher effects of TMT. By cluster-analyzing…

  20. Communication, Values, and Popular Television Series--A Seventeen-Year Assessment.

    ERIC Educational Resources Information Center

    Chesebro, James W.

    1991-01-01

    Employs a dramatistic system based on the critical frameworks of Kenneth Burke and Northrop Frye to analyze 903 prime-time network television series. Classifies series as ironic, mimetic, leader-centered, romantic, or mythical. Concludes that over the period from 1974-91, series went from individualism, to idealism and authority, to authority…

  1. Common Core Companion: The Standards Decoded What They Say, What They Mean, How to Teach Them

    ERIC Educational Resources Information Center

    Burke, Jim

    2013-01-01

    "The Common Core Companion: The Standards Decoded", by Jim Burke, provides schools, districts, and departments with a common language or set of reference points for effective school-wide implementation of the Common Core State Standards. The book--available in middle and high school editions--clarifies what each standard says, what each…

  2. Constructing Vocational Identities.

    ERIC Educational Resources Information Center

    Phillips, Tom

    1995-01-01

    Four texts were analyzed using Burke's model for explicating dramatic experiences: Bennett's "Clayhanger," Lawrence's "The Rainbow," a biography of Elizabeth Barrett Browning, and Blythe's "Akenfield." Analysis shows how vocational exploration is a form of personal project during which individuals socially construct an identity. (SK)

  3. KSC-03PD-2707

    NASA Technical Reports Server (NTRS)

    2003-01-01

    KENNEDY SPACE CENTER, FLA. United Space Alliance employees (from left) Daryl Burke, Jay Beason and Tom Summers check new tiles installed on the heat shield of main engine 1 for the orbiter Discovery. A heat shield is a protective layer on a spacecraft designed to protect it from the high temperatures, usually those that result from aerobraking during reentry into the Earths atmosphere.

  4. A Burkeian Analysis of the "Political Correctness" Confrontation in Higher Education.

    ERIC Educational Resources Information Center

    Bello, Richard

    1996-01-01

    Explains that Kenneth Burke's concept of "terministic screen" reveals three rhetorical strategies that those on both sides of the political correctness debate share: unique labeling phraseologies, pugilistic mystification, and a dependence on different pentadic ratios. Concludes with an appraisal of possible future trends. (TB)

  5. Trigonometry with Year 8: Part 1

    ERIC Educational Resources Information Center

    Steer, Jessica; de Vila, Maria Antioneta; Eaton, James

    2009-01-01

    The authors explore the teaching of trigonometry using a method developed by Jeremy Burke of Kings College. A series of lessons was planned using an approach which looks at moving from a mathematical description of the topic, to a sequence plan, to a set of activities, which students can use to help them come to understand the topic. This is…

  6. Overcoming Communication Obstacles through Films in the Classroom.

    ERIC Educational Resources Information Center

    Higgins, Mary Anne

    C.M. Condit (1986) has pointed out that audiences regard characterizations as the most salient feature of any text. The power of identification or "the result of all the components in the rhetorical act" (K. Burke, 1945, 1950) is compelling. The power generated by viewers' responses to character-centered films can be harnessed in the classroom to…

  7. Perspectivism and Form in Drama: A Burkean Analysis of "Julius Caesar."

    ERIC Educational Resources Information Center

    Weier, Gary M.

    1996-01-01

    Employs a critical application of Kenneth Burke's notions of form and perspectivism. Argues for the potential of a complementary relationship between form and perspectivism in the appeal of rhetorical artifacts. Claims that form is perspectival, limiting possibilities for appropriate interpretations within a text. Applies this theoretical…

  8. Science Sublime: The Philosophy of the Sublime, Dewey's Aesthetics, and Science Education

    ERIC Educational Resources Information Center

    Cavanaugh, Shane

    2014-01-01

    Feelings of awe, wonder, and appreciation have been largely ignored in the working lives of scientists and, in turn, science education has not accurately portrayed science to students. In an effort to bring the affective qualities of science into the classroom, this work draws on the writings of the sublime by Burke, Kant, Emerson, and Wordsworth…

  9. Drama in the Archives: Rereading Methods, Rewriting History

    ERIC Educational Resources Information Center

    Glenn, Cheryl; Enoch, Jessica

    2009-01-01

    This article examines the historiographic trajectory of rhetoric and composition studies by analyzing archival research practices, using Kenneth Burke's dramatistic pentad as our analytical tool. We rely on a Burkean framework of "scenes, acts, agents, agencies, purposes, and attitudes" to invigorate our understanding of historiographic methods…

  10. Evidence-Based Management Education

    ERIC Educational Resources Information Center

    Burke-Smalley, Lisa A.

    2014-01-01

    In this rejoinder to "Let's Burn Them All: Reflections on the Learning-Inhibitory Nature of Introduction to Management and Introduction to Organizational Behavior Textbooks," by Robert A. Snyder (see EJ1039748), Lisa Burke-Smalley touches upon a number of Snyder's claims and explores questions sparked by his essay. She argues…

  11. Hope in Uncertainty

    ERIC Educational Resources Information Center

    Miranda, Maria Eugenia

    2012-01-01

    When President Barack Obama announced that he would direct the Department of Homeland Security to grant deferred deportation and a work permit for two years to undocumented immigrant youth who meet certain criteria, he renewed hope for a better future for a million young people. Lauren Burke, an adjunct law professor at Brooklyn College of Law and…

  12. Making Differences in the Composition Class: A Philosophy of Invention.

    ERIC Educational Resources Information Center

    Covino, William A.

    1981-01-01

    Surveys rhetorical invention in current theoretical terms. Suggests that all invention requires the location of "differences" within a structure of free play imposed by the mind. Presents some important links between invention, J. Derrida's concept of "difference," and K. Burke's idea of eloquence. (RL)

  13. Rhetorical and Communication Theory: An Area of Interface.

    ERIC Educational Resources Information Center

    Baker, C. Scott; Fadely, Dean

    A study examined identification and consistency theory of interface between rhetorical and communication theory, to demonstrate the compatibility of specific principles in Kenneth Burke's theory with those in the work of Fritz Heider and other consistency theorists and to make suggestions toward a Burkeian theory of identification through…

  14. A tridimensional representation of enzyme inhibition useful for diagnostic purposes.

    PubMed

    Fontes, R; Ribeiro, J M; Sillero, A

    1994-01-01

    A new three dimensional representation of enzyme inhibition, applied to Lineweaver-Burk, Hanes and Eadie-Hofstee plots is presented. This type of representation has advantages for enzyme inhibition diagnosis, showing graphic characteristics that pass unnoticed in linear plots. PMID:7539074

  15. African Americans in Adult Education: The Harlem Renaissance Revisited

    ERIC Educational Resources Information Center

    Johnson-Bailey, Juanita

    2006-01-01

    This study examined a 25-year period of African Americans in adult education by accessing the archival holdings of three major data centers: the Schomburg Center for Research in Black Culture, the Moorland-Spingarn Archives, and the Hollis Burke Frissell Library. The sociopolitical context of the data was analyzed using a Black feminist…

  16. Two Thinking Skills Assessment Approaches: "Assessment of Pupils' Thinking Skills" and "Individual Thinking Skills Assessments"

    ERIC Educational Resources Information Center

    Burke, Lynsey A.; Williams, Joanne M.

    2012-01-01

    This paper is linked to a previous paper outlining an evaluation of a thinking skills intervention (Burke & Williams, 2008). Following extensive requests for the assessment tools used in the intervention, this short paper presents the development and potential uses of two thinking skills assessment tools. The aim of the paper is simply to make…

  17. "Reality" Revisited: Self-Assessment of Terministic Screens through a Political Autobiography Assignment

    ERIC Educational Resources Information Center

    Hunter, Karla M.

    2016-01-01

    Courses: Argumentation, Public Speaking, Political Communication. Objectives: After completing this unit activity, students should be able to (1) demonstrate comprehension of Burke's (1941) concept of terministic screens; (2) apply the concept of terministic screens to write a brief political autobiography of themselves that analyzes the history…

  18. High-Impact Training Solutions: Top Issues Troubling Trainers.

    ERIC Educational Resources Information Center

    Burke, Lisa A., Ed.

    Designed for front-line training professionals, this book addresses the most pressing issues in the training and development field (T&D). "Introduction" (Lisa A. Burke) discusses the importance of viewing training as a subsystem of human resources, training as a systematic process, and indicators of high impact training. "Strategic Training:…

  19. Toward a Theory of Liking

    ERIC Educational Resources Information Center

    Burke, Kevin; Greteman, Adam

    2013-01-01

    In the current essay, Kevin Burke and Adam Greteman challenge this thing called love by looking at how we might instead "like" in education. Within education, multiculturalism can be viewed as a way of loving, or learning to love, diversity and, as such, learning to love the self; this tendency is notably apparent in the recent rise of concern…

  20. Examining the Choice of Business Majors to Participate in a Short-Term Study Abroad Program Using the Gap Analysis Model

    ERIC Educational Resources Information Center

    Vera Lopez, Janet

    2013-01-01

    The Clark and Estes (2008) Gap Analysis Process Model (Gap Analysis) was used to examine the reasons 33% of freshmen students do not participate in the Burke School of Business, Business Abroad Experience (BAE) program at New Wave University (NWU). The purpose of this study was to understand the considerations students make in their…

  1. Unit 1204: The Evaluation of Persuasive Discourse.

    ERIC Educational Resources Information Center

    Minnesota Univ., Minneapolis. Center for Curriculum Development in English.

    This unit for grade 12 is intended to provide an introduction to the criticism of persuasive discourse. After a brief discussion of the definition of criticism, the unit proceeds to the establishment of standards for evaluating persuasive discourse, standards involving Kenneth Burke's pentad: act, scene, agent, agency, and purpose. The unit then…

  2. Changing Lives: Women, Inclusion and the PhD

    ERIC Educational Resources Information Center

    Cole, Barbara Ann, Ed.; Gunter, Helen, Ed.

    2010-01-01

    Heidi Safia Mirza, Penny Jane Burke, Jennifer Lavia, Gloria Gordon, Helen Gunter and Barbara Ann Cole each tells her story of completing doctoral studies at a particular personal and professional stage in her life. Their narratives reveal their experience of the resultant life changes and will speak to people who are at different stages in their…

  3. 50 Essential Lessons: Tools and Techniques for Teaching English Language Arts. [Multimedia Kit

    ERIC Educational Resources Information Center

    Burke, Jim

    2006-01-01

    "50 Essential Lessons" is the result of the lessons Jim Burke learned while asking himself how to teach his students the skills they needed to succeed in school and in the larger world. Anchored in standards shared by a range of national literacy documents, these lessons focus on the core cognitive and personal skills--reading, writing, speaking…

  4. Diagnosis of Enzyme Inhibition Using Excel Solver: A Combined Dry and Wet Laboratory Exercise

    ERIC Educational Resources Information Center

    Dias, Albino A.; Pinto, Paula A.; Fraga, Irene; Bezerra, Rui M. F.

    2014-01-01

    In enzyme kinetic studies, linear transformations of the Michaelis-Menten equation, such as the Lineweaver-Burk double-reciprocal transformation, present some constraints. The linear transformation distorts the experimental error and the relationship between "x" and "y" axes; consequently, linear regression of transformed data…

  5. Methamphetamine and the Changing Face of Child Welfare: Practice Principles for Child Welfare Workers

    ERIC Educational Resources Information Center

    Connell-Carrick, Kelli

    2007-01-01

    Methamphetamine use and production is changing child welfare practice. Methamphetamine is a significant public health threat (National Institute of Justice, 1999) reaching epidemic proportions (Anglin, Burke, Perrochet, Stamper, & Dawud-Nouris, 2000). The manufacturing of methamphetamine is a serious problem for the child welfare system, yet child…

  6. Verbal Patterns in Dyadic Interaction.

    ERIC Educational Resources Information Center

    Ayres, Joe; Ivie, Robert L.

    Selected aspects of Kenneth Burke's "dramatistic" model of symbolic interaction were operationalized to describe and compare verbal patterns in transactions between five pairs of friends and five pairs of strangers. Based on Altman and Taylor's social penetration theory, it was predicted that interactants would display verbal patterns unique to…

  7. Fulfilling the Promise of Abbott: The Lighthouse Assessment Process--Improving Programs through Measured Outcomes. Policy Progress, Spring 2004

    ERIC Educational Resources Information Center

    Association for Children of New Jersey, 2004

    2004-01-01

    In an attempt to better prepare young children for the challenges of kindergarten and first grade, the Supreme Court of New Jersey, in its 1998 landmark decision of "Abbott v. Burke" (Abbott V), required the State's poorest school districts to implement high quality, intensive preschool for all 3-and 4-year old children. To take advantage of the…

  8. Public Data Set: Erratum: "Multi-point, high-speed passive ion velocity distribution diagnostic on the Pegasus Toroidal Experiment" [Rev. Sci. Instrum. 83, 10D516 (2012)

    DOE Data Explorer

    Burke, Marcus G. [University of Wisconsin-Madison] (ORCID:0000000176193724); Fonck, Raymond J. [University of Wisconsin-Madison] (ORCID:0000000294386762); Bongard, Michael W. [University of Wisconsin-Madison] (ORCID:0000000231609746); Schlossberg, David J. [University of Wisconsin-Madison] (ORCID:0000000287139448); Winz, Gregory R. [University of Wisconsin-Madison] (ORCID:0000000177627184)

    2016-07-18

    This data set contains openly-documented, machine readable digital research data corresponding to figures published in M.G. Burke et al., 'Erratum: "Multi-point, high-speed passive ion velocity distribution diagnostic on the Pegasus Toroidal Experiment" [Rev. Sci. Instrum. 83, 10D516 (2012)],' Rev. Sci. Instrum. 87, 079902 (2016).

  9. The Rhetorical Construction of the Nation in Education: The Case of Flanders

    ERIC Educational Resources Information Center

    Rutten, Kris; Mottart, Andre; Soetaert, Ronald

    2010-01-01

    This paper examines what can be learnt from "new rhetoric" (focusing on the work of the American rhetorician Kenneth Burke [1897-1993]) about (national) identity and discusses how nationalism can be taught from such a rhetorical perspective. Despite the "deconstruction" of nation(alism) as a grand narrative, there is a new tendency towards…

  10. Domal structure in Devonian rocks of Kimberling basin, Bland County, Virginia

    SciTech Connect

    McDowell, R.C.

    1988-08-01

    The Kimberling basin, which is floored with Middle Devonian clastic rocks, is a topographic and structural low in the Narrows fault block of the southern Appalachian Valley and Ridge province in Bland County, Virginia. The basin is bounded on the northwest and southeast by the southeast-dipping Narrows and Saltville thrust faults, respectively. Two doubly plunging anticlines lie along the strike of the basin. Lower Ordovician rocks are exposed in the Burkes Garden dome to the southwest, and Lower Cambrian rocks are present in the core of the Bane dome to the northeast. Previous workers have postulated continuity between the Burkes Garden and Bane domes through the Kimberling basin, as well as the presence in the basin of an anomalously thick Devonian clastic section, which has been ascribed by some authors to contemporaneous downwarp of a depositional syncline. Recent mapping has shown both of these postulates to be incorrect. The basin contains an anticline-syncline pair that is en echelon with the axes of the Burkes Garden and Bane anticlines and that trends about 20/degree/ more northerly than the regional strike of the bounding thrusts. Rediscovery of small outcrops of Lower and Middle Devonian Huntersville Chert and Rocky Gap Sandstone in the core of the Kimberling basin anticline, which were recorded by M.R. Campbell in 1896 but overlooked by later mappers, shows that the Devonian clastic sequence has a normal thickness and that the Kimberling basin contains a domal structure similar to the Burkes Garden and Bane domes.

  11. Form, Experience and the Centrality of Rhetoric to Pedagogy

    ERIC Educational Resources Information Center

    Brummett, Barry

    2015-01-01

    This essay notes a resurgence of interest in rhetorical studies on the appeal of form, grounded in the work of rhetorical theorist Kenneth Burke. The essay argues that form is not only a way to structure discourses, it is a way to structure experience. Form is foundational in creating perceptions and thus experiences. Form is also highly…

  12. The Role of Aesthetic Theory in (Mass) Communications Theory.

    ERIC Educational Resources Information Center

    Theall, Donald F.

    This study in human communications ranges widely over scholarly work by Barthes, Bateson, Dewey, Richards, Peckham, Burke, and especially McLuhan, as well as art works by Warhol, Joyce, and various vodeo tape and film makers. In surveying the developments in art and advertising, the author finds that the arts (1) are now a kind of laboratory for…

  13. Dhurrin content relates to sorghum [sorghum bicolor (L.) Moench] seedling growth in marginal soils

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Dhurrin content in leaves of mature sorghum plant is a quantitative measure of the level of pre-and postflowering drought tolerance (Burke et al., 2013). Postflowering drought tolerance in sorghum is linked to the staygreen (delayed senescence) trait (Howarth, 2000; Rosenow et al., 1977) which has ...

  14. Persistence among African American Males in the Honors College

    ERIC Educational Resources Information Center

    Anderson Goins, Johnell Roxann

    2014-01-01

    Retaining African American students, specifically African American males, is an issue that plagues the American higher education system. Research shows that African American male students are the lowest represented group in the gifted studies programs (Ford, 2010). Lockie and Burke (1999); Chen and DeJardins (2010) and Bell (2010a) found that…

  15. Vocational Training and Lifelong Learning in Australia and Germany. Australia Centre Series.

    ERIC Educational Resources Information Center

    Burke, Gerald, Ed.; Reuling, Jochen, Ed.

    This document contains 17 papers on vocational training and lifelong learning in Australia and Germany. The following papers are included: "Vocational Training and Lifelong Learning in Australia and Germany: Background" (Gerald Burke); "Vocational Training and Lifelong Learning in Australia: Observations and Conclusions from a German Perspective"…

  16. Learning-Style Assessment in Online Courses: A Prerequisite for Academic Success

    ERIC Educational Resources Information Center

    Gicco, Gina

    2014-01-01

    Educational researchers have extensively documented the benefits of utilizing learning styles in the processes of teaching and learning from early childhood to Adult Education (Burke & Dunn, 2003; Cicco, 2009). This article examines the need to consider and employ learning-styles instruction in the online classroom. Adult learners are unique…

  17. Charlie's Words: Supporting Gifted Male Athletes Using Athletes' Journals

    ERIC Educational Resources Information Center

    Kent, Richard

    2012-01-01

    A gifted student-athlete, Charlie Bloomfield is introduced to athlete's journals by his coaches at Burke Mountain Academy (Vermont), an elite American ski school. Used by Olympians and professionals alike, journals provide athletes with ways to organize and reflect on training and competitions. Athlete's journals help gifted male athletes address…

  18. Nasal corticosteroid sprays

    MedlinePlus

    ... Burks AW, et al., eds. In: Middleton's Allergy Principles and Practice . 8th ed. Philadelphia, PA: Elsevier Mosby; 2013:chap 42. Wallace DV, Dykewicz MS, Bernstein DI, et al. The diagnosis and management of rhinitis: an updated practice parameter. J Allergy ...

  19. Assessing Success in School Finance Litigation: The Case of New Jersey. Education, Equity, and the Law. No. 1

    ERIC Educational Resources Information Center

    Goertz, Margaret E.; Weiss, Michael

    2009-01-01

    Education finance policy in New Jersey has been shaped by over 30 years of school finance litigation. Through its decisions in "Robinson v. Cahill" (1973-1976) and "Abbott v. Burke" (1985-2005), the justices of New Jersey's supreme court have defined the state's constitutional guarantee of a "thorough and efficient" education, set parameters for…

  20. Early Childhood Education: The Sustainability of the Benefits of Preschool Participation in Abbott Districts

    ERIC Educational Resources Information Center

    Fernandez, Norma

    2010-01-01

    The landmark New Jersey Supreme Court school funding case, "Abbott v. Burke", established the availability of preschool for all three- and four-year-olds living within the state's thirty-one poorest districts as a means of eradicating the effects of poverty. Longitudinal studies have shown the value of high quality preschool programs for improving…

  1. Looking into a Crystal Ball: Is Requiring High-Stakes Language Proficiency Tests Really Going to Improve World Language Education?

    ERIC Educational Resources Information Center

    Burke, Brigid M.

    2013-01-01

    Brigid Burke is the program coordinator of World Language Education at her university, which is housed in the College of Education and Human Development. Since obtaining this position 4 years ago, she has become most concerned about certain recommendations that were made by the American Council on the Teaching of Foreign Languages (ACTFL) in 2002,…

  2. BLACK BELT SCHOOLS--BEYOND DESEGREGATION.

    ERIC Educational Resources Information Center

    GREEN, DONALD ROSS; AND OTHERS

    IN 1964, FOUR PROFESSORS FROM THE DIVISION OF TEACHER EDUCATION AT EMORY UNIVERSITY VISITED SCHOOL SYSTEMS IN BURKE COUNTY, GEORGIA, AND EDGEFIELD COUNTY, SOUTH CAROLINA. IN THIS SUBSEQUENT REPORT, THE AUTHORS CONTEND THAT THE ACT OF DESEGREGATION DOES NOT IN AND OF ITSELF REMOVE THE OMNIPRESENT PROBLEM OF POOR EDUCATIONAL OPPORTUNITY IN THE…

  3. Instructions for Systemic Change

    ERIC Educational Resources Information Center

    Seigel, Marika A.

    2009-01-01

    In the technical communication classroom, the received wisdom is that good instructions should "stay out of the way" of the users' engagement with technological systems. This article draws on Burke's concept of perspective by incongruity and on examples of instructions produced during the Women's Health Movement to demonstrate that sometimes…

  4. Order and Mystery in Negotiation Groups.

    ERIC Educational Resources Information Center

    Putnam, Linda L.; Bullis, Connie

    A preliminary study investigating the perceptions of intergroup relations in the bargaining process supports Kenneth Burke's concepts of order and mystery. Questionnaires, interviews, and direct observations of teachers' and school boards' teams involved in contract negotiations show that people closest to the bargaining saw more order in the…

  5. The Rhetoric of Al-Anon: A Burkeian Analysis.

    ERIC Educational Resources Information Center

    Zimmerman, Stephanie

    A study employed a Burkeian framework in order to determine the nature of Al-Anon's rhetoric and evaluate the success of the organization's rhetorical strategies in appealing to the co-alcoholic population that it addresses. According to Kenneth Burke, a message is persuasive if the audience perceives a commonality with the central beliefs of the…

  6. Celebrating the Constitution: A Bicentennial Retrospective.

    ERIC Educational Resources Information Center

    Walch, Timothy G., Ed.

    1988-01-01

    This commemorative document was published to celebrate the Bicentennial of the signing of the U.S. Constitution and to pay tribute to the bicentennial celebration efforts of the U.S. National Archives and Records Administration staff. The included articles are: (1) "Introduction: A Celebration at the National Archives" (F. Burke); (2) "The Odyssey…

  7. Rhetorical Theory in the 21st Century.

    ERIC Educational Resources Information Center

    Brock, Bernard L.

    Kenneth Burke, in his book "Permanence and Change" (1935) predicted that, as a result of the dehumanizing and alienation of people by technology, the 300-year reign of science that supplanted the age of religion and still prevails today would be replaced by poetic humanism as the new orientation. Current changes within rhetorical theory as a…

  8. What Lies Ahead.

    ERIC Educational Resources Information Center

    Bennis, Warren; Burke, W. Warner; Gery, Gloria; Juechter, W. Mathew; Rummler, Geary; Tichy, Noel

    2003-01-01

    Six training industry leaders ( Warren Bennis, W. Warner Burke, Gloria Gery, W. Mathew Juechter, Geary Rummler, and Noel Tichy) look at the future of the industry. Themes include the crisis of leadership in the wake of corporate scandals and challenges for organizational learning and development. (JOW)

  9. Regrinding the Lens of Gender: Problematizing "Writing as a Woman."

    ERIC Educational Resources Information Center

    Graves, Heather Brodie

    1993-01-01

    Argues that codifying the characteristics of "writing like a woman" (or like a man) can result in a limited--and limiting--conception of gender and its effect on writing. Uses the writing of Kenneth Burke as an example of "l'ecriture feminine" and the prose of Julia Kristeva as an example of writing like a man. (SR)

  10. Other People's Schools: The Challenge of Building New Schools in New Jersey's Urban Districts: 2000-2010

    ERIC Educational Resources Information Center

    Daniel, Robert S.

    2013-01-01

    This dissertation captures the 10-year contemporary history of implementing the facilities element of New Jersey's historic Abbott v. Burke decision. New Jersey's Legislature and Governor took this Supreme Court decision and created legislation responding to multiple constituencies and lobbyists while shaping a school construction…

  11. Mythical Structures in Community Vision.

    ERIC Educational Resources Information Center

    Burke, Ken

    To negotiate a balance between an ideological concern for society's historical-economic development and an understanding of the individual's need for a sense of self-realization, social theory researchers should look to B. Dervin's "gap theory model" of communication. Adapted from Kenneth Burke, it offers a dynamic means of understanding how…

  12. Student Drivers Will Find This Defensive Course Difficult

    ERIC Educational Resources Information Center

    Nation's Schools, 1972

    1972-01-01

    Map and description of 40-acre defensive driving range being built for secondary school driver education programs in the Burke County Public Schools of North Carolina. Features include a beginner course, streets, driveways, expressway, gravel road, a driver education building, and an emergency skid area. (Author/DN)

  13. "Prophesying after the Event": The Archeology and Ecology of Genre.

    ERIC Educational Resources Information Center

    Coe, Richard M.

    "Genre" has become the keyword in a movement to create a more dynamic, dialectical, contextual conception of "dispositio," of structure as a factor in psychological and social processes of writing. A dynamic conception of genre as social process in symbolic action can be reached by combining Kenneth Burke's technique of "prophesying after the…

  14. "Movement as Motive": Self Definition and Social Advocacy in Social Movement Autobiographies.

    ERIC Educational Resources Information Center

    Griffin, Charles J. G.

    2000-01-01

    Contributes to scholarship advancing the understanding of human communication by elaborating a theoretical framework for understanding the synthesis of self-definition and social advocacy in social movement autobiographies. Uses insights from Kenneth Burke and posits that in a rhetorically effective movement autobiography, form enables the…

  15. The Scapegoating of Bruno Richard Hauptmann: The Rhetorical Process in Prejudicial Publicity.

    ERIC Educational Resources Information Center

    Wilkie, Carol

    1981-01-01

    Examines the publicity in the 1935 trial for the kidnapping and death of Charles Lindbergh's son. Applies Burke's theory of human victimage. Concludes that this case may be one of the most blatant examples of journalistic scapegoating in history and a graphic illustration of publicity becoming dangerously prejudicial. (PD)

  16. Chiara Lubich's 1977 Templeton Prize Acceptance Speech: Case Study in the Mystical Narrative.

    ERIC Educational Resources Information Center

    Cali, Dennis D.

    1993-01-01

    Illuminates Kenneth Burke's characteristics of a mystical rhetoric as they issue from "purpose" as a dominant dramatistic element. Offers a case study in mystical rhetoric by identifying the essential qualities of a mystical narrative and demonstrating how these qualities operate in Chiara Lubich's 1977 Templeton Prize Acceptance Speech. (SR)

  17. Ecological Stewardship and Gifted Children

    ERIC Educational Resources Information Center

    McHardy, Roberta J.; Blanchard, Pamela B.; de Wet, Catharina F.

    2009-01-01

    In even the earliest studies of giftedness in young children (Burks, Jensen, & Terman, 1930; Hollingworth, 1926), researchers noted distinct character traits among gifted students, which included global awareness, sensitivity to complex issues, and a tendency to worry about injustice and dangers that often are beyond a child's control. Dabrowski…

  18. Aesthetic Pursuits: Windows, Frames, Words, Images--Part II

    ERIC Educational Resources Information Center

    Burke, Ken

    2005-01-01

    In Part I of this study (Burke, 2005), the author presented the essentials of Image Presentation Theory--IPT--and its application to the analytical explication of various spatial designs in and psychological responses to images, from the illusions of depth in what is referred to as "windows" in cinema theory to the more patterned abstractions of…

  19. Exclusion, Engagement and Identity Construction in a Socioeconomically Diverse Middle School Wind Band Classroom

    ERIC Educational Resources Information Center

    Hoffman, Adria Rachel

    2012-01-01

    The purpose of this multiple case study was to explore the wind band classroom as a social context and examine its influence on middle-school students' identity constructions. The integration of sociologically based identity theory and social identity theory from social psychology suggested by Deaux and Martin as well as Stets and Burke proved…

  20. Burkean Tropes and Kuhnian Science: A Social Constructionist Perspective on Language and Reality.

    ERIC Educational Resources Information Center

    Schiappa, Edward

    1993-01-01

    Constructs a language-centered perspective toward the social-rhetorical construction of knowledge by juxtaposing Kenneth Burke's philosophy of language with Thomas S. Kuhn's philosophy of science. Discusses rhetoric's epistemic status and the social constructionist account of discourse production. (HB)

  1. Maximizing School Guidance Program Effectiveness: A Guide for School Administrators & Program Directors.

    ERIC Educational Resources Information Center

    Dykeman, Cass, Ed.

    Twenty-three brief chapters provide administrators a comprehensive guide to school counseling that describes practices, problems, and processes for which school counselors' expertise may be relied on. Chapters are: (1) "Comprehensive School Counseling Programs" (Z. VanZandt, K. H. Burke, M. J. DeRespino); (2) "The Elementary School Counseling…

  2. Diagnosis and Remediation Practices for Troubled School Children

    ERIC Educational Resources Information Center

    Burks, Harold F.

    2008-01-01

    In this resource for educators, Harold F. Burks offers a comprehensive guide to the evaluation techniques and intervention strategies that have worked with many school children experiencing problems. Thus, this book attempts to: clarify the understanding of observed, unwanted child behavior symptoms (whether they be physical, intellectual,…

  3. Decision-Making Models with Sets of Strategies for Applications to Individuals and Groups in Higher Education.

    ERIC Educational Resources Information Center

    Gill, Wanda E.

    Three decision-making models that have applications for college presidents and administrators are reviewed. While both individual and group decision-making are addressed, emphasis is placed on the importance of group decisions on institutional policy planning. The model of Edmund M. Burke (1979) presents specific decision-making strategies in…

  4. Erratum: “Multi-point, high-speed passive ion velocity distribution diagnostic on the Pegasus Toroidal Experiment” [Rev. Sci. Instrum. 83, 10D516 (2012)

    DOE PAGESBeta

    Burke, Marcus G.; Fonck, Raymond J.; Bongard, Michael W.; Schlossberg, David J.; Winz, Gregory R.

    2016-07-18

    This article corrects an error in M.G. Burke et al., 'Multi-point, high-speed passive ion velocity distribution diagnostic on the Pegasus Toroidal Experiment,' Rev. Sci. Instrum. 83, 10D516 (2012) pertaining to ion temperature. The conclusions of this paper are not altered by the revised ion temperature measurements.

  5. The Neural Correlates of Inhibiting Pursuit to Smoothly Moving Targets

    ERIC Educational Resources Information Center

    Burke, Melanie Rose; Barnes, Graham R.

    2011-01-01

    A previous study has shown that actively pursuing a moving target provides a predictive motor advantage when compared with passive observation of the moving target while keeping the eyes still [Burke, M. R., & Barnes, G. R. Anticipatory eye movements evoked after active following versus passive observation of a predictable motion stimulus. "Brain…

  6. Making Light of James Watt: A Burkean Approach to the Form and Attitude of Political Cartoons.

    ERIC Educational Resources Information Center

    Bostdorff, Denise M.

    1987-01-01

    Explores the rhetorical nature of political cartoons by applying Kenneth Burke's concepts and terminology to this graphic art form. Examines (1) formal strategy of "perspective by incongruity," (2) burlesque attitude in political cartoons, and (3) fusion of form and attitude in the tropal principles of this graphic art. Draws from political…

  7. "Response to Comments": Straw Makeovers, Dogmatic Holism, and Interesting Conversation

    ERIC Educational Resources Information Center

    Howe, Kenneth R.

    2009-01-01

    This paper presents the author's response to commentaries by Eric Bredo, R. Burke Johnson, and Linda Tillman on his article "Positivist Dogmas, Rhetoric, and the Education Science Question." Each of the commentaries goes beyond merely characterizing and assessing the author's analysis to also suggest an alternative emphasis, if not an alternative…

  8. Metaphor, Ambiguity, and Motive in Evolutionary Biology: W. D. Hamilton and the "Gene's Point of View"

    ERIC Educational Resources Information Center

    Journet, Debra

    2005-01-01

    This article analyzes the power of ambiguous metaphors to present scientific novelty. Its focus is a series of papers by the prominent population biologist W. D. Hamilton in which he redefined the meaning of biological altruism. In particular, the article draws on Kenneth Burke's dramatistic pentad to examine why suggestions of motive are so…

  9. The Homology Hypothesis: Pornography on the VCR.

    ERIC Educational Resources Information Center

    Brummett, Barry

    1988-01-01

    Argues that texts may be especially rhetorically effective when the content, the medium used to convey the content, and the real life experiences that make the content relevant are formally or structurally similar. Suggests that formal linkage creates rhetorical effect, and uses Burke's theory of forms to explain the effect of formal links. (MS)

  10. The Cost of High-Quality Pre-School Education in New Jersey

    ERIC Educational Resources Information Center

    Belfield, Clive; Schwartz, Heather

    2007-01-01

    This report calculates the full cost of providing well-planned, high quality pre-school for children in New Jersey, as required under "Abbott vs. Burke" (153 NJ 480 1998). The evidence on how high-quality pre-school improves the academic performance of children is compelling. After a rapid expansion over the last decade, many children in the…

  11. Toward Construct Validation of a Transfer Climate Instrument. [and] Improving Positive Transfer: A Test of Relapse Prevention Training on Transfer Outcomes.

    ERIC Educational Resources Information Center

    Holton, Elwood F., III; And Others

    1997-01-01

    Includes "Toward Construct Validation of a Transfer Climate Instrument" (Holton et al.); "Improving Positive Transfer: A Test of Relapse Prevention Training on Transfer Outcomes" (Burke); "Invited Reaction: Progress or Relapse?" (Newstrom); "Invited Reaction: Theory, Research, and Practice" (Tang); "Final Word: Reply to Newstrom's and Tang's…

  12. An Exploratory Study of Faculty Members' Perceptions of Their Rhetorical Sensitivity in Informal and Formal Communication Situations.

    ERIC Educational Resources Information Center

    McDowell, Earl E.

    R. Hart and D. Burks (1972) indicated that rhetorical sensitivity (RS) is a cognitive orientation to communication competence that stresses the importance of appropriate adaptation and flexibility in interpersonal communication interactions. In 1980, Hart, Carlson and Eadie developed an instrument called RHETSEN scale, a 40-item questionnaire. The…

  13. 78 FR 45987 - Vogtle Electric Generating Station, Units 3 and 4; Southern Nuclear Operating Company; Change to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-30

    ... Register on February 19, 2013 (78 FR 11693). The January 25, 2013 supplement revised the original no... the Primary Sampling System AGENCY: Nuclear Regulatory Commission. ACTION: Exemption and combined..., located in Burke County, Georgia. The amendment requests to modify the Primary Sampling System...

  14. 78 FR 45989 - Vogtle Electric Generating Station, Units 3 and 4; Southern Nuclear Operating Company; Change to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-30

    ... Register on February 19, 2013 (78 FR 11693). The January 25, 2013 supplement revised the original no... the Primary Sampling System AGENCY: Nuclear Regulatory Commission. ACTION: Exemption and combined..., located in Burke County, Georgia. The amendment requests to modify the Primary Sampling System...

  15. Learning in Context

    ERIC Educational Resources Information Center

    Burke, Scott; Moore, Tom

    2009-01-01

    When geometry and career and technical education (CTE) are cotaught in the process of building a house, learning is enhanced, test scores improve, and there's a waiting list of students wanting in. Geometry in Construction is a class instructed by the authors--a CTE teacher (Scott Burke) and a mathematics teacher (Tom Moore). While Moore instructs…

  16. Factors Influencing Sharing Activities in Transnational Public Sector Knowledge Networks: The Case of Mobile Disease Surveillance System Adoption in the 2009 Hajj

    ERIC Educational Resources Information Center

    Gharawi, Mohammed A.

    2012-01-01

    This dissertation contributes to the growing base of theory relating to Transnational Public Sector Knowledge Networks (TPSKNs) presented by Dawes, Gharawi, and Burke (2012). A case study explores the TPSKN formed between the United States Center for Disease Control and the Saudi Arabian Ministry of Health ahead of the 2009 Hajj, one of the…

  17. Getting It Right from the Start: The Case for Early Parenthood Education

    ERIC Educational Resources Information Center

    Sticht, Thomas G.

    2011-01-01

    The idea that families need to provide enriching educational activities is not new. In 1908, Edmund Burke Huey, regarded as "one of the foremost leaders" in educating children with learning disabilities, wrote, "The school of the future will have as one of its important duties the instruction of parents in the means of assisting the child's…

  18. Burkian Ratios and Clement Haynesworth: A Proposed Method and Application.

    ERIC Educational Resources Information Center

    Vibbert, Steven L.

    Kenneth Burke's 20 ratios permit the rhetorical critic to make very specific statements about the discourse under analysis and open the way for analytic speculation. The ratio method permits the critic to describe and understand the specific qualities of practical ethical dispute. Burkian ratios were employed to analyze the justificatory rhetoric…

  19. The Cigarette as Representational Ideograph in the Debate over Environmental Tobacco Smoke.

    ERIC Educational Resources Information Center

    Moore, Mark P.

    1997-01-01

    Argues that the social construction of the cigarette in divergent synecdochic forms or "representational ideographs" is based on varying degrees of narrative and scientific knowledge. Broadens the existing theoretical perspective derived from Kenneth Burke and Michael McGee to include Jean-Francois Lyotard's view of narrative and scientific…

  20. Drama in Life: The Uses of Communication in Society.

    ERIC Educational Resources Information Center

    Combs, James E.; Mansfield, Michael W.

    Bringing together 35 of the most notable contributions of authors such as Kenneth Burke, Erving Goffman, and Eric Berne, this book provides an introduction to the dramaturgical perspective of social actions. Selections stem from the conception that many "real-life" actions and events can most adequately be understood in terms of drama. Included…

  1. Conducting Qualitative Data Analysis: Qualitative Data Analysis as a Metaphoric Process

    ERIC Educational Resources Information Center

    Chenail, Ronald J.

    2012-01-01

    In the second of a series of "how-to" essays on conducting qualitative data analysis, Ron Chenail argues the process can best be understood as a metaphoric process. From this orientation he suggests researchers follow Kenneth Burke's notion of metaphor and see qualitative data analysis as the analyst systematically considering the "this-ness" of…

  2. Toward Reconstructing the Narrative of Teacher Education: A Rhetorical Analysis of "Preparing Teachers"

    ERIC Educational Resources Information Center

    Bullough, Robert V., Jr.

    2014-01-01

    Drawing on insights from literary critic and theorist Kenneth Burke, this rhetorical analysis of "Preparing Teachers" (2010), a publication of the National Research Council, reveals then critiques' key assumptions that are shaping policies and current reform efforts in teacher education, including changes in U.S. teacher…

  3. Ethnographic Research on Word Recognition Strategies of Adult Beginning Readers: Summary Report.

    ERIC Educational Resources Information Center

    Boraks, Nancy; Schumacher, Sally

    A study was conducted to describe factors influencing the acquisition of facilitating and inhibiting reading strategies by adult beginning readers (ABRs) in order to generate potential guidelines for instruction. Using an adapted form of the Goodman and Burke taxonomy of oral reading miscues as initial framework, the investigators described ABRs'…

  4. Ethnographic Research on Word Recognition Strategies of Adult Beginning Readers: Technical Report.

    ERIC Educational Resources Information Center

    Boraks, Nancy; Schumacher, Sally

    This study was undertaken to identify the reading strategies which facilitated or inhibited the progress of adult beginning readers (ABRs). An ethnographic approach was used so that factors influencing the ABRs' acquisition of these reading strategies could be identified. Using an adapted form of the Goodman and Burke taxonomy of oral reading…

  5. A new polyoxygenated farnesylcyclohexenone from Fungus Penicillium sp.

    PubMed

    Yang, Yabin; Yang, Fangfang; Zhao, Lixing; Duang, Rongting; Chen, Guangyi; Li, Xiaozhan; Li, Qiling; Qin, Shaohuan; Ding, Zhongtao

    2016-01-01

    A new polyoxygenated farnesylcyclohexenone, peniginsengin A (1), was isolated from the fermentation of Penicillium sp. YIM PH30003, an endophytic fungus associated with Panax notoginseng (Burk.) F. H. Chen. The structure was assigned based on a combination of 1 D and 2 D NMR and mass spectral data. The cytotoxicity and antimicrobial activities of compound 1 were investigated. PMID:25906789

  6. Notable Black Women.

    ERIC Educational Resources Information Center

    Ellin, Nancy

    Readings, activities, and teaching strategies for a secondary unit on black women are included in this teacher handbook. Instructional material is divided into four sections. Following a note on the use of the booklet, section 1 consists of 24 two-page biographies of black women, including Selma Burke, Lena Horne, Leontyne Price, Charlayne…

  7. DACA-Lamented? Spared Deportation, Immigrant Students Still Face Higher Ed Barriers

    ERIC Educational Resources Information Center

    Burke, Lauren A.

    2014-01-01

    In this brief article, immigration lawyer and executive director of Atlas: DIY Lauren Burke describes the challenges faced by "DACA-mented" students--those who have received deportation reprieve through President Obama's 2012 memorandum. Atlas: DIY (www.atlasdiy.org) is a cooperative center for undocumented youth and their allies in…

  8. Critical Understanding: The Powers and Limits of Pluralism.

    ERIC Educational Resources Information Center

    Booth, Wayne C.

    The problems created by the competing claims of various schools of criticism for a unified view of meaning are examined in this book. Chapters deal with the following topics: the problem of the plurality of modes, Ronald Crane and the pluralism of discrete modes, Kenneth Burke's multiplication of perspectives, history as criticism and the…

  9. Cleansing the Superdome: The Paradox of Purity and Post-Katrina Guilt

    ERIC Educational Resources Information Center

    Grano, Daniel A.; Zagacki, Kenneth S.

    2011-01-01

    The reopening of the New Orleans Superdome after Hurricane Katrina on Monday Night Football dramatized problematic rhetorical, visual, and spatial norms of purification rituals bound up in what Burke calls the paradox of purity. Hurricane Katrina was significant as a visually traumatic event in large part because it signified the ghetto as a…

  10. Donning Sackcloth and Ashes: "Webster vs. Reproductive Health Services" and Moral Agony in Abortion Rights Rhetoric.

    ERIC Educational Resources Information Center

    Tonn, Mari Boor

    1996-01-01

    Argues that the topos of moral agony (resembling Kenneth Burke's purifying concept of mortification) adopted by some abortion rights rhetors to allay public discomfort with abortion is rhetorically and politically self-defeating. Shows how it couches moral anguish in atypical tales of tragic circumstances and unattainable motherhood. Argues that…

  11. Burned in: Fueling the Fire to Teach

    ERIC Educational Resources Information Center

    Friedman, Audrey A.; Reynolds, Luke

    2011-01-01

    Almost half of new teachers leave the profession within their first year. New teachers need support, mentoring, encouragement, and, most importantly, hope in order to survive the challenges of their first years of teaching. "Burned In" features essays from today's most visionary educators, including Jim Burke, Peter Elbow, James Loewen, Gregory…

  12. Dhurrin content relates to sorghum (Sorghum bicolor (L) Moench) seedling growth in marginal soils.

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Dhurrin content in leaves of mature sorghum plant is a quantitative measure of the level of pre-and postflowering drought tolerance (Burke et al., 2013). Postflowering drought tolerance in sorghum is linked to the staygreen (delayed senescence) trait (Howarth, 2000; Rosenow et al., 1977) which has b...

  13. The Status and Challenges of Higher Education Curricula Reforms in Four Highly Developed Regional/National Settings

    ERIC Educational Resources Information Center

    Gilder, Eric

    2011-01-01

    In this article (part one of two) I will consider, using the dramatistic model pioneered by Kenneth Burke, the "scene" or historical cultural ground of each "highly developed' national/regional area (The EU, the USA, Hong Kong [SAR], and Singapore) in terms of their Higher Education (HE) systems. After these analyses, then I look to…

  14. Accountability through Assessment of Administrative Organizations in Higher Education

    ERIC Educational Resources Information Center

    Kniola, David J.

    2013-01-01

    Accountability is among the least understood policy issues in higher education (Burke 2005). The rapid rise in tuition costs in both public and private institutions (Heller 2006) in all corners of the globe (Altbach, Reisberg, and Rumbley 2009) has challenged the idea of higher education as a public good. Student learning outcomes is one…

  15. Shakespeare's Poetics of Play-Making and Therapeutic Action in "The Tempest."

    ERIC Educational Resources Information Center

    Reed, Melissa Ann

    2000-01-01

    Practices Kenneth Burke's rhetoric of empathic identification to read and understand six levels of consubstantiality between Shakespeare and his Elizabethan audience blueprinted by the authorized text of "The Tempest." Offers implications for the contemporary practices of poetry and drama therapy with participants capable of self-differentiation.…

  16. Analysis of lithium driven electron density peaking in FTU liquid lithium limiter experiments

    NASA Astrophysics Data System (ADS)

    Szepesi, G.; Romanelli, M.; Militello, F.; Peeters, A. G.; Camenen, Y.; Casson, F. J.; Hornsby, W. A.; Snodin, A. P.; Wágner, D.; the FTU Team

    2013-03-01

    The impact of lithium impurities on the microstability and turbulent transport characteristics in the core of a typical FTU liquid lithium limiter (LLL) (Mazzitelli et al 2011 Nucl. Fusion 51 073006) discharge during the density ramp-up phase is studied. A non-linear gyrokinetic analysis performed with GKW (Peeters et al 2009 Comput. Phys. Commun. 180 2650) accompanied by a quasi-linear fluid analysis is presented. We show that a centrally peaked, high concentration lithium profile contributes to the electron peaking by reducing the outward electron flux, and that it leads to inward turbulent deuterium transport through ion flux separation.

  17. Comment on 'Turbulent equipartition theory of toroidal momentum pinch' [Phys. Plasmas 15, 055902 (2008)

    SciTech Connect

    Peeters, A. G.; Angioni, C.; Strintzi, D.

    2009-03-15

    The comment addresses questions raised on the derivation of the momentum pinch velocity due to the Coriolis drift effect [A. G. Peeters et al., Phys. Rev. Lett. 98, 265003 (2007)]. These concern the definition of the gradient, and the scaling with the density gradient length. It will be shown that the turbulent equipartition mechanism is included within the derivation using the Coriolis drift, with the density gradient scaling being the consequence of drift terms not considered in [T. S. Hahm et al., Phys. Plasmas 15, 055902 (2008)]. Finally the accuracy of the analytic models is assessed through a comparison with the full gyrokinetic solution.

  18. On the structure of gaseous confined laminar diffusion flames: Numerical investigation

    NASA Technical Reports Server (NTRS)

    Mawid, M. A.; Bulzan, D. L.; Aggarwal, S. K.

    1993-01-01

    The structure and characteristics of gaseous confined laminar diffusion flames are investigated by numerically solving the time-dependent two-dimensional axisymmetric conservation equations. The numerical model accounts for the important chemical and physical processes involved, including axial diffusion, viscous effects, radial convection, and finite-rate chemistry. The numerical results clearly show that the flame has a finite thickness and leakage of fuel vapor into the flame zone is possible. The effect of heat release is found to induce some radial flow. Predicted flame shape and dimensions are compared to the classical Burke-Schumann flame. The numerically calculated flame is observed to be about 15 percent taller and 5 percent narrower than that of the Burke-Schumann solution under the same conditions.

  19. Applying Density Functional Theory for Atomic Vacancies in Solids

    NASA Astrophysics Data System (ADS)

    Zhou, Xiaolan; Perdew, John P.

    2008-03-01

    We use a new generalized gradient approximation of density functional theory -- PBEsol, a revised Perdew-Burke-Ernzerhof GGA, to calculate the vacancy formation energies and other properties of metals and semiconductors: Al, Pt, Pd, GaN [1], etc. By restoring the gradient expansion over a wide range of density gradients, PBEsol [2] yields excellent jellium exchange and correlation surface energies. We expect that this new functional will improve the description of vacancies in real materials, since the vacancy formation energy is essentially the work needed to create an interior surface. [1] Thomas R.Mattsson and Ann E. Mattson. Phys. Rev. B 66, 214410 (2002). [2] John P. Perdew, Adrienn Ruzsinszky, Gabor I. Csonka, Oleg A. Vydrov, Gustavo E. Scuseria, Lucian A. Constantin, Xiaolan Zhou, and Kieron Burke, Restoring the density-gradient expansion for exchange in solids and surfaces, http://arxiv.org/abs/0711.0156

  20. Summary of the March 25--26, 1991 atmospheric model working meeting

    SciTech Connect

    Ramsdell, J.V.

    1992-07-01

    Atmospheric transport and diffusion calculations for the initial phase of the Hanford Environmental Dose Reconstruction (HEDR) Project were made using the MESOILT2 computer code (Ramsdell and Burk 1991). This code implemented a Lagrangian trajectory, puff dispersion model using components from other models designed primarily for regulatory applications. Uncertainty in the dispersion calculations was estimated following model calculations. The results of the atmospheric dispersion calculations were summarized in frequency distributions by location for use in preliminary dose calculations.

  1. Summary of the March 25--26, 1991 atmospheric model working meeting. Hanford Environmental Dose Reconstruction Project

    SciTech Connect

    Ramsdell, J.V.

    1992-07-01

    Atmospheric transport and diffusion calculations for the initial phase of the Hanford Environmental Dose Reconstruction (HEDR) Project were made using the MESOILT2 computer code (Ramsdell and Burk 1991). This code implemented a Lagrangian trajectory, puff dispersion model using components from other models designed primarily for regulatory applications. Uncertainty in the dispersion calculations was estimated following model calculations. The results of the atmospheric dispersion calculations were summarized in frequency distributions by location for use in preliminary dose calculations.

  2. Revamping the Classroom Research Project

    ERIC Educational Resources Information Center

    Werner-Burke, Nanci

    2014-01-01

    Too often, students don't feel engaged in their research projects. The problem begins as early as the topic-creation stage, when students may choose from a list of teacher-selected topics that don't interest them or struggle to select a single fruitful topic on their own. Nanci Werner-Burke describes how two students in an English…

  3. Australia announces plans for expanded marine reserve network

    NASA Astrophysics Data System (ADS)

    Showstack, Randy

    2012-06-01

    Australia announces plans for expanded marine reserve network The Australian government has announced plans to increase the nation's network of marine reserves from 27 to 60, bringing the total size of the network to 3.1 million square kilometers, Australia's environment minister Tony Burke said on 14 June. The expansion, which would place more than one third of Australia's waters under protection, requires a 60-day consultation before it can become law.

  4. Comparative study of exchange-correlation functionals for accurate predictions of structural and magnetic properties of multiferroic oxides

    NASA Astrophysics Data System (ADS)

    Chen, Hanghui; Millis, Andrew J.

    2016-05-01

    We systematically compare predictions of various exchange correlation functionals for the structural and magnetic properties of perovskite Sr1 -xBaxMnO3 (0 ≤x ≤1 )—a representative class of multiferroic oxides. The local spin density approximation (LSDA) and spin-dependent generalized gradient approximation with Perdew-Burke-Ernzerhof parametrization (sPBE) make substantial different predictions for ferroelectric atomic distortions, tetragonality, and ground state magnetic ordering. Neither approximation quantitatively reproduces all the measured structural and magnetic properties of perovskite Sr0.5Ba0.5MnO3 . The spin-dependent generalized gradient approximation with Perdew-Burke-Ernzerhof revised for solids parametrization (sPBEsol) and the charge-only Perdew-Burke-Ernzerhof parametrized generalized gradient approximation with Hubbard U and Hund's J extensions both provide overall better agreement with measured structural and magnetic properties of Sr0.5Ba0.5MnO3 , compared to LSDA and sPBE. Using these two methods, we find that different from previous predictions, perovskite BaMnO3 has large Mn off-center displacements and is close to a ferromagnetic-to-antiferromagnetic phase boundary, making it a promising candidate to induce effective giant magnetoelectric effects and to achieve cross-field control of polarization and magnetism.

  5. A new multi-wavelength model-based method for determination of enzyme kinetic parameters.

    PubMed

    Sorouraddin, Mohammad-Hossein; Amini, Kaveh; Naseri, Abdolhossein; Vallipour, Javad; Hanaee, Jalal; Rashidi, Mohammad-Reza

    2010-09-01

    Lineweaver-Burk plot analysis is the most widely used method to determine enzyme kinetic parameters. In the spectrophotometric determination of enzyme activity using the Lineweaver-Burk plot, it is necessary to find a wavelength at which only the substrate or the product has absorbance without any spectroscopic interference of the other reaction components. Moreover, in this method, different initial concentrations of the substrate should be used to obtain the initial velocities required for Lineweaver-Burk plot analysis. In the present work, a multi-wavelength model-based method has been developed and validated to determine Michaelis-Menten constants for some enzyme reactions. In this method, a selective wavelength region and several experiments with different initial concentrations of the substrate are not required. The absorbance data of the kinetic assays are fitted by non-linear regression coupled to the numeric integration of the related differential equation. To indicate the applicability of the proposed method, the Michaelis-Menten constants for the oxidation of phenanthridine, 6-deoxypenciclovir and xanthine by molybdenum hydroxylases were determined using only a single initial concentration of the substrate, regardless of any spectral overlap. PMID:20826949

  6. Impact of the background toroidal rotation on particle and heat turbulent transport in tokamak plasmas

    SciTech Connect

    Camenen, Y.; Peeters, A. G.; Casson, F. J.; Hornsby, W. A.; Snodin, A. P.; Angioni, C.; Strintzi, D.

    2009-01-15

    Recent developments in the gyrokinetic theory have shown that, in a toroidal device, the Coriolis drift associated with the background plasma rotation significantly affects the small scale instabilities [A. G. Peeters et al., Phys. Rev. Lett. 98, 265003 (2007)]. The later study, which focuses on the effect of the Coriolis drift on toroidal momentum transport is extended in the present paper to heat and particle transport. It is shown numerically using the gyrokinetic flux-tube code GKW[A. G. Peeters and D. Strintzi, Phys. Plasmas 11, 3748 (2004)], and supported analytically, that the Coriolis drift and the parallel dynamics play a similar role in the coupling of density, temperature, and velocity perturbations. The effect on particle and heat fluxes increases with the toroidal rotation (directly) and with the toroidal rotation gradient (through the parallel mode structure), depends on the direction of propagation of the perturbation, increases with the impurity charge number and with the impurity mass to charge number ratio. The case of very high toroidal rotation, relevant to spherical tokamaks, is investigated by including the effect of the centrifugal force in a fluid model. The main effect of the centrifugal force is to decrease the local density gradient at the low field side midplane and to add an extra contribution to the fluxes. The conditions for which the inertial terms significantly affect the heat and particle fluxes are evidenced.

  7. Viral determinants of rotavirus pathogenicity in pigs: production of reassortants by asynchronous coinfection.

    PubMed

    Tauscher, G I; Desselberger, U

    1997-01-01

    A porcine rotavirus (prv), variant 4F, isolated in tissue culture from the feces of a Chinese pig with diarrhea, was found to have become highly pathogenic when passaged in gnotobiotic piglets (J. C. Bridger, B. Burke, G. M. Beards, and U. Desselberger, J. Gen. Virol. 73:3011-3015, 1992). Comparison with the closely related pig-apathogenic variant prv 4S suggested the outer capsid protein VP4 (encoded by RNA 4) of prv 4F as a determinant for pathogenicity (B. Burke, J. C. Bridger, and U. Desselberger, J. Gen. Virol. 75:2205-2212, 1994; B. Burke, J. C. Bridger, and U. Desselberger, Virology 202:754-759, 1994). In order to provide more direct evidence, the pathogenic prv 4F variant which grows and forms plaques poorly in tissue culture was reassorted with the well-tissue-culture-adapted, pig-apathogenic bovine rotavirus (brv; UK Compton strain). After asynchronous coinfection of cell cultures (first prv 4F, followed by brv 6 to 12 h later), several reassortants were isolated containing RNA 4 of prv 4F either alone (isolate B-F4) or together with one or two other genes of 4F in the genetic background of brv. Backcrossing of the monoreassortant B-F4 with prv 4S yielded a monoreassortant, S-F4, which carries RNA 4 of the 4F variant in the genetic background of prv 4S. The in vitro growth characteristics of these reassortants were analyzed, and the roles of VP4 in plaque formation and growth kinetics in cell culture were confirmed. The monoreassortant S-F4 and the parental viruses prv 4F and prv 4S are currently being tested for pathogenicity in gnotobiotic piglets (J. C. Bridger, G. Tauscher, and U. Desselberger, unpublished data). PMID:8985430

  8. Sensitivity of High-Resolution Simulations of Hurricane Bob (1991) to Planetary Boundary Layer Parameterizations

    NASA Technical Reports Server (NTRS)

    Braun, Scott A.; Tao, Wei-Kuo

    1999-01-01

    The MM5 mesoscale model is used to simulate Hurricane Bob (1991) using grids nested to high resolution (4 km). Tests are conducted to determine the sensitivity of the simulation to the available planetary boundary layer parameterizations, including the bulk-aerodynamic, Blackadar, Medium-RanGe Forecast (MRF) model, and Burk-Thompson boundary-layer schemes. Significant sensitivity is seen, with minimum central pressures varying by up to 17 mb. The Burk-Thompson and bulk-aerodynamic boundary-layer schemes produced the strongest storms while the MRF scheme produced the weakest storm. Precipitation structure of the simulated hurricanes also varied substantially with the boundary layer parameterizations. Diagnostics of boundary-layer variables indicated that the intensity of the simulated hurricanes generally increased as the ratio of the surface exchange coefficients for heat and momentum, C(sub h)/C(sub M), although the manner in which the vertical mixing takes place was also important. Findings specific to the boundary-layer schemes include: 1) the MRF scheme produces mixing that is too deep and causes drying of the lower boundary layer in the inner-core region of the hurricane; 2) the bulk-aerodynamic scheme produces mixing that is probably too shallow, but results in a strong hurricane because of a large value of C(sub h)/C(sub M) (approximately 1.3); 3) the MRF and Blackadar schemes are weak partly because of smaller surface moisture fluxes that result in a reduced value of C(sub h)/C(sub M) (approximately 0.7); 4) the Burk-Thompson scheme produces a strong storm with C(sub h)/C(sub M) approximately 1; and 5) the formulation of the wind-speed dependence of the surface roughness parameter, z(sub 0), is important for getting appropriate values of the surface exchange coefficients in hurricanes based upon current estimates of these parameters.

  9. Hydrogeologists honored for service

    NASA Astrophysics Data System (ADS)

    Back, Bill

    Joseph F. Poland and Stanley W. Lohman, retired U.S. Geological Survey hydrogeologists, were honored at the recent annual meeting of the Geological Society of America in Orlando, Fla., with the 1985 Award for Distinguished Service in Hydrology. The first award, in 1984, was given posthumously to George Burke Maxey. The award is based on “history of sustained creditable service to the hydrogeologic profession.” In August, Poland also received the American Water Resources Association's Honorary Member Award, which recognizes individuals with eminence in a branch of water resources science and technology.

  10. Plume Generation Zones On The Core Mantle Boundary: their origin and what they tell about how the Earth works - and how it has worked (Arthur Holmes Medal Lecture)

    NASA Astrophysics Data System (ADS)

    Burke, Kevin

    2014-05-01

    It is more than 50 years since Wilson (1963) suggested that a fixed plume of deep origin from the convecting mantle is generating the Hotspots of the Hawaiian chain on the overlying moving rigid lithosphere and nearly 45 years since Morgan (1972) followed by suggesting that the plumes which generate Hotspots rise only from the Core/Mantle Boundary (CMB). During the past ~ 15 years testing has begun of a refinement of Morgan's idea based on the observation that Plumes responsible for Hotspots, Large Igneous Provinces (LIPs) and a significant fraction of other igneous rocks (including kimberlites) originate only in Plume Generation Zones (PGZs) at the edges on the CMB of one or other of TUZO and JASON the 2 antipodal, equatorial, Large Low Shear Wave Velocity Provinces (LLSVPs) of the deep mantle (Garnero et al. 2007) or from similar PGZs at the edges on the CMB of ~8 smaller Low Shear Wave Velocity Provinces. Today I will: (i) demonstrate using dated Hotspot, Large Igneous Province and Kimberlite occurrence history and paleomagnetic rotations (e.g. Torsvik et al. 2010, Burke et al.2008) the stability throughout the past 0.55 Ga of the LLSVPs and LSVPs (ii) show from the history of the Earth and Mars how the LLSVPs and LSVPs are likely to have formed early in Earth history and to have been stable since ~ 4.4 Ga (Burke et al. 2012) (iii) show, following an analogy suggested by Jack Whitehead of similarity to atmospheric fronts, why plumes are generated only from PGZs on the CMB at the margins of LLSVPs and LSVPs. (iv) show from results of recent seismological studies of Iceland, Jan Mayen, Hawaii, Yellowstone, the Afar and Ontong Java, that although plumes rise vertically in the deep mantle from the CMB their fate in the top ~ 1, 000 km of the mantle is proving to be varied and to depend largely, as Wilson suggested, on how they interact with the plates above them. Properties of the Plume Generation Zones (PGZs) on the CMB and of the plumes that rise from them are

  11. [The leprosy "drama": Governador Valadares, public health policies, and their territorial implications in the 1980s].

    PubMed

    Genovez, Patrícia Falco; Pereira, Flávia Rodrigues

    2016-01-01

    The incidence of leprosy in Governador Valadares, Brazil, in the 1980s spurred this town to pioneer the introduction of polychemotherapy. The aim of this research was to understand how the different actors involved in this context interacted, especially the employees and patients at the Special Public Health Service. To identify the territories that these interactions inevitably constituted, a variety of theoretical instruments were used, including dramatism (Burke) and performance (Turner). By taking a theatrical metaphor, we sought to find out the dynamics by which the different actors took the stage and established their most significant relationships in a dynamic process of constituted and reconstituted territories. PMID:27276042

  12. Urethane as an inhibitor of the firefly light reaction

    SciTech Connect

    Nehls, S.M.; Bittar, E.E. )

    1989-01-01

    A study has been made to test the hypothesis that general anesthetics such as urethane are able to inhibit light from a firefly reaction mixture. Urethane was found to reduce light emission in a dose-dependent manner, the minimal effective concentration being about 20 mM. Dixon plots gave a Ki value in the range of 175 to 215 mM. Lineweaver-Burk plots showed that urethane increases the apparent Km for ATP and reduces V{sub max} for the reaction. This is taken to mean that urethane acts as both a competitive and noncompetitive inhibitor of the firefly light reaction (mixed-type inhibition).

  13. Study of structural and electronic properties of ScN and ScAs in rocksalt and zincblende structure: A DFT approach

    SciTech Connect

    Nayak, Vikas Verma, U. P.

    2015-08-28

    In this paper, we have studied the structural and electronic properties of ScN and ScAs in zincblende (ZB) and rocksalt (RS) phases. We have employed the full potential linearized augmented plane wave (FP-APW) method within the density functional theory (DFT). Generalized gradient approximation (GGA), due to Perdew-Burke-Ernzerhof (PBE) has been used to estimate the exchange-correlation functional. Our band structure results for ScN shows the metallic nature, whereas ScAs shows the semiconducting behavior. The obtained results are in excellent agreement with earlier reported data.

  14. Determination of the electronic, dielectric, and optical properties of sillenite Bi12TiO20 and perovskite-like Bi4Ti3O12 materials from hybrid first-principle calculations.

    PubMed

    Lardhi, Sheikha; Noureldine, Dalal; Harb, Moussab; Ziani, Ahmed; Cavallo, Luigi; Takanabe, Kazuhiro

    2016-04-01

    Density functional theory calculation was conducted to determine the optoelectronic properties of bismuth titanate sillenite (Bi12TiO20) and perovskite-like (Bi4Ti3O12) structures. The lattice parameters were experimentally obtained from Rietveld analysis. The density functional perturbation theory approach was used with the standard Perdew-Burke-Ernzerhof functional and screened Coulomb hybrid Heyd-Scuseria-Ernzerhof functional to investigate the electronic structure and absorption coefficient. Both compounds have good carrier transport properties, low effective hole and electron masses, high dielectric constant, and low exciton binding energy. PMID:27059580

  15. Number of deployments, relationship satisfaction and perpetration of partner violence among U.S. Navy members.

    PubMed

    Kelley, Michelle L; Stambaugh, Leyla; Milletich, Robert J; Veprinsky, Anna; Snell, Alicia K

    2015-08-01

    The present brief report examined whether number of deployments, relationship satisfaction, and the interaction between number of deployments and relationship satisfaction predicted Navy members' reports of perpetrating physical partner violence. Participants were 80 U.S. Navy members assigned to an Arleigh Burke-class destroyer anticipating an 8-month deployment after Operation Enduring Freedom/Operation Iraqi Freedom. The effect that the number of deployments had on perpetrating physical partner violence diminished as relationship satisfaction increased. Results suggest the importance of designing domestic violence intervention and treatment efforts toward those who report high levels of deployment and low relationship satisfaction. PMID:26053344

  16. DFT investigation on structure, electronic and magnetic properties of Crn (n=2-8) clusters

    NASA Astrophysics Data System (ADS)

    Shah, Esha V.; Kumar, Vipin; Roy, Debesh R.

    2016-05-01

    A density functional investigation on the series of chromium clusters, i.e., Crn (n=2-8) is performed for finding their lowest energy structures and various electronic and magnetic properties. For electronic properties, we have predicted binding energy, HOMO-LUMO (HLG), chemical hardness (η) etc., and also for magnetic behavior, we have predicted the magnetic moments of the lowest energy cluster isomers. A systematic search imposing all possible initial magnetic configurations of the clusters is considered for finding lowest energy structures. All the calculations is carried out using a very popular GGA functional Perdew, Burke and Ernzerhof (PBE), as implemented in the VASP code.

  17. Importance of complex orbitals in calculating the self-interaction-corrected ground state of atoms

    SciTech Connect

    Kluepfel, Simon; Kluepfel, Peter; Jonsson, Hannes

    2011-11-15

    The ground state of atoms from H to Ar was calculated using a self-interaction correction to local- and gradient-dependent density functionals. The correction can significantly improve the total energy and makes the orbital energies consistent with ionization energies. However, when the calculation is restricted to real orbitals, application of the self-interaction correction can give significantly higher total energy and worse results, as illustrated by the case of the Perdew-Burke-Ernzerhof gradient-dependent functional. This illustrates the importance of using complex orbitals for systems described by orbital-density-dependent energy functionals.

  18. A revised classification of the Icteridae (Aves) based on DNA sequence data.

    PubMed

    Remsen, J V Jr; Powell, Alexis F L A; Schodde, Richard; Barker, F Keith; Lanyon, Scott M

    2016-01-01

    The higher-level classification of the New World blackbirds (Icteridae; Aves) has remained relatively stable for nearly a half-century, with most currently used classifications (e.g. Sibley & Monroe 1990; Jaramillo & Burke 1999; Fraga 2011; Remsen et al. 2015) following Blake's (1968) delimitation and sequence of genera in the Peters Check-list of Birds of the World series. Early molecular studies (e.g., Lanyon 1992, 1994; Johnson & Lanyon 1999; Price & Lanyon 2002; Cadena et al. 2004) produced only minor modifications. PMID:27394496

  19. Theoretical prediction of structural and elastic behavior of AlRu under pressure: A FP-LAPW study

    NASA Astrophysics Data System (ADS)

    Jain, Ekta; Pagare, Gitanjali; Devi, Hansa; Sanyal, S. P.

    2015-06-01

    Using full potential linearized augmented plane wave (FP-LAPW) method, the structural and elastic properties of AlRu intermetallic compound have been determined within the framework of density functional theory (DFT). The exchange correlation potential is used for generalized gradient approximations in the scheme of Perdew-Burke-Ernzerhof (GGA-PBE), Wu-Cohen (GGA-WC) and Perdew et. al. (GGA-PBEsol). Furthermore we have analyzed the trend of elastic constants (C11, C12 and C44) and elastic moduli (B, G and E) under variable pressure.

  20. Structural, electronic and optical properties of Li intercalated on MO3 (M: Mo, W): A first principle investigation

    NASA Astrophysics Data System (ADS)

    Mahmoudi, A.; Faraoun, H. I.; Benabadji, M. K.; Abdellaoui, I.; Dergal, M.

    2016-03-01

    The correlations between electronic and optical properties of pure MO3 (M=Mo, W) and the effect of Li intercalated in the matrix are investigated within density functional theory using both the revised gradient-corrected Perdew-Burke-Ernzerhof (GGA-PBE), GGA+U and HSE06 functional frameworks along with ab initio pseudopotentials method. Calculation performed with HSE06 functional proves that all these compounds are wide band gap semiconductors. The energy gap value is found to decrease with lithium incorporation, affecting the visible absorption coefficients.

  1. Theoretical investigation on structural and electronic properties of PdO{sub 2}

    SciTech Connect

    Viswanathan, E.; Sundareswari, M. E-mail: sundare65@gmail.com; Jayalakshmi, D. S.; Manjula, M.

    2015-06-24

    Theoretical studies on rutile type Palladium Dioxide were carried out with the aim of analyzing structural and electronic properties at ambient condition using the first principle calculation based on density functional theory. Within the framework of density functional theory, we used full potential linearized augmented plane wave method(FP-LAPW) in Wien 2k code. The exchange and correlation effect is treated with generalized gradient approximation (GGA) using the Perdew, Burke and Eruzeroff form. The charge density plots, density of states and band structure are plotted and discussed.

  2. Astronaut Virgil Grissom at Gemini 3 crew breakfast before launch

    NASA Technical Reports Server (NTRS)

    1965-01-01

    Astronaut Virgil I. Grissom (second from left), command pilot of the Gemini-Titan 3 flight, is shown during a steak breakfast which he was served about two hours prior to the launch. Others seated at the table are (left to right), Donald K. Slayton, Assistant Director for Flight Crew Operations; Walter Burke (back to camera), General Mangaer of McDonnell Aircraft Corportation Spacecraft and Missiles; Walter C. Williams, former Deputy Director of the Manned Spacecraft Center; and Astronaut Alan B. Shepard Jr.

  3. Complete QED theory of multiphoton Trident pair production in strong laser fields.

    PubMed

    Hu, Huayu; Müller, Carsten; Keitel, Christoph H

    2010-08-20

    Electron-positron pair creation by multiphoton absorption in the collision of a relativistic electron with a strong laser beam is calculated within laser-dressed quantum electrodynamics. Total production rates, positron spectra, and relative contributions of different reaction channels are obtained in various interaction regimes. We study the process in a manifestly nonperturbative domain which is shown accessible to future experiments utilizing the electron beam lines at novel x-ray laser facilities or all-optical setups based on laser acceleration. Our theory moreover allows us to add further insights into the experimental data from SLAC [D. Burke, Phys. Rev. Lett. 79, 1626 (1997).]. PMID:20868080

  4. Instrument Quality Control.

    PubMed

    Jayakody, Chatura; Hull-Ryde, Emily A

    2016-01-01

    Well-defined quality control (QC) processes are used to determine whether a certain procedure or action conforms to a widely accepted standard and/or set of guidelines, and are important components of any laboratory quality assurance program (Popa-Burke et al., J Biomol Screen 14: 1017-1030, 2009). In this chapter, we describe QC procedures useful for monitoring the accuracy and precision of laboratory instrumentation, most notably automated liquid dispensers. Two techniques, gravimetric QC and photometric QC, are highlighted in this chapter. When used together, these simple techniques provide a robust process for evaluating liquid handler accuracy and precision, and critically underpin high-quality research programs. PMID:27316990

  5. Hydrogen molecule on lithium adsorbed graphene: A DFT study

    NASA Astrophysics Data System (ADS)

    Kaur, Gagandeep; Gupta, Shuchi; Gaganpreet, Dharamvir, Keya

    2016-05-01

    Electronic structure calculations for the adsorption of molecular hydrogen on lithium (Li) decorated and pristine graphene have been studied systematically using SIESTA code [1] within the framework of the first-principle DFT under the Perdew-Burke-Ernzerhof (PBE) form of the generalized gradient approximation (GGA)[2], including spin polarization. The energy of adsorption of hydrogen molecule on graphene is always enhanced by the presence of co-adsorbed lithium. The most efficient adsorption configuration is when H2 is lying parallel to lithium adsorbed graphene which is in contrast to its adsorption on pristine graphene (PG) where it prefers perpendicular orientation.

  6. Lunar optical telescopes: An historical perspective

    NASA Technical Reports Server (NTRS)

    Johnson, Stewart W.

    1992-01-01

    There is a long history of thought and discussion on the possibilities of astronomical observatories on the Moon. Numerous ideas have been suggested and a variety of concepts have resulted for lunar optical telescopes. This paper reviews some of the ideas and efforts of individuals and working groups including Hershel, Clarke, Malina, Herbig, and Hess; working groups of the 1960s; and recent initiatives of Burke, Burns, and others. The enhanced technologies of the 1980s and 1990s can make past dreams of lunar observatories come to reality in the 21st century.

  7. Normal Modes of Magnetized Finite Two-Dimensional Yukawa Crystals

    NASA Astrophysics Data System (ADS)

    Marleau, Gabriel-Dominique; Kaehlert, Hanno; Bonitz, Michael

    2009-11-01

    The normal modes of a finite two-dimensional dusty plasma in an isotropic parabolic confinement, including the simultaneous effects of friction and an external magnetic field, are studied. The ground states are found from molecular dynamics simulations with simulated annealing, and the influence of screening, friction, and magnetic field on the mode frequencies is investigated in detail. The two-particle problem is solved analytically and the limiting cases of weak and strong magnetic fields are discussed.[4pt] [1] C. Henning, H. K"ahlert, P. Ludwig, A. Melzer, and M.Bonitz. J. Phys. A 42, 214023 (2009)[2] B. Farokhi, M. Shahmansouri, and P. K. Shukla. Phys.Plasmas 16, 063703 (2009)[3] L. Cândido, J.-P. Rino, N. Studart, and F. M. Peeters. J. Phys.: Condens. Matter 10, 11627--11644 (1998)

  8. Automatic vigilance: the attention-grabbing power of approach- and avoidance-related social information.

    PubMed

    Wentura, D; Rothermund, K; Bak, P

    2000-06-01

    The automatic processing of information was investigated, varying valence (positive vs. negative) and relevance (other-relevant traits [ORT] vs. possessor-relevant traits [PRT]; G. Peeters, 1983) of stimuli. ORTs denote unconditionally positive or negative consequences for persons in the social environment of the holder of the trait (e.g., honest, brutal) whereas PRTs denote unconditionally positive or negative consequences for the trait holder (e.g., happy, depressive). In 2 experiments using the Stroop paradigm, larger interference effects were found for ORTs than PRTs. This is due to the behavior-relatedness of ORTs. In a go/no-go lexical decision task (Experiment 3), participants either had to withdraw their finger from a pressed key (i.e., "avoid") or had to press a key (i.e., "approach") if a word was presented. Responses to negative ORTs were relatively faster in the withdraw condition, whereas positive ORTs were relatively faster in the press condition. PMID:10870906

  9. Evolution of the southeast Atlantic thermocline during Marine Isotopic Stages 6-5: is it related to variations in the Agulhas Leakage?

    NASA Astrophysics Data System (ADS)

    Scussolini, P.; Peeters, F. J. C.

    2012-04-01

    The inter-basin exchange of Indian Ocean waters into the South Atlantic via the Agulhas Leakage (AL) is considered a modulator of Atlantic Meridional Overturning Circulation. Paleoceanographic studies show that increased inputs of saline and relatively warm Agulhas Current waters are associated with late Pleistocene deglaciations. This suggests that this transfer of water masses may effectively regulate the buoyancy of the (South) Atlantic Ocean, and consequently the strength of the Atlantic thermohaline overturning. Our aim is to detect changes in the southeast Atlantic thermocline that may be dynamically linked to variations in the intensity of the AL. To test this relationship, within the frame of EU Marie Curie GATEWAYS project, we are studying a marine sediment record from the central Walvis Ridge, a site that is presently underneath the trajectory of northwest migrating Agulhas Rings. We focus on the δ18O and Mg/Ca ratio of certain planktic foraminifera species that are known to dwell at different depths in the upper ocean, in order to reconstruct the properties of water masses during the last two glacial cycles. The results so far show changes in the δ18O difference (Δδ18O) between surface and thermocline species along Marine Isotopic Stage 6. Such difference is interpreted as a proxy for the thermal gradient of the upper ca. 400 m of the water column. We conclude that the observed changes in the southeast Atlantic thermocline do not coincide with the AL peaks as indicated by published faunal counts (Peeters et al. 2004). The Mg/Ca paleotemperature proxy will be implemented to improve the interpretation of the hydrographic mechanisms underlying the observed changes in thermocline properties. Ref.: Peeters, F.J.C. et al., 2004. Vigorous exchange between the Indian and Atlantic oceans at the end of the past five glacial periods. Nature, 430(7000): 661-665.

  10. Psychoanalytic theory in times of terror.

    PubMed

    Connolly, Angela

    2003-09-01

    Recent events have underlined in the most tragic and dramatic way the need for depth psychology to turn its attention to the psychology of terror. The present paper attempts to distinguish between the psychological modes of horror and terror and explores the different theoretical approaches of Burke, Freud, Kristeva and Jung to this problem in order to cast light on the individual and collective functions that horror and terror play. While all these authors stress that terror and horror play a role in structuring the sense of identity and in strengthening community bonds, Freud and Kristeva believe that the experience of horror works to increase the exclusion of otherness through mechanisms of repression or foreclosure while Burke and Jung see in the encounter with the Negative Sublime or with the Shadow the possibility of widening the boundaries of ego consciousness and of integration of 'otherness'. The paper then uses the analysis of two horror movies and of a particular socio-cultural context to illustrate these different functions of horror and terror and to delineate possible solutions to the problems facing society. PMID:14513476

  11. What does it means to be a critical scholar? A metalogue between science education doctoral students

    NASA Astrophysics Data System (ADS)

    Cian, Heidi; Dsouza, Nikeetha; Lyons, Renee; Alston, Daniel

    2016-04-01

    This manuscript is written in response to Lydia Burke and Jesse Bazzul's article Locating a space of criticality as new scholars in science education. As doctoral students finding our place in the culture of science education, we respond by discussing our journeys towards the development of a scholarly identity, with particular focus on whether or how we see ourselves as critical scholars. Since each of us authoring this paper has a different perspective, a metalogue format is utilized to ensure all of our voices and journeys are represented. We use the Burke and Bazzul article as a platform for conversations about challenges faced for emerging scholars in the field of science education and explore how we see our role in responding to these challenges. Specifically, we discuss the barriers to publication, dissemination of research to practitioners, and how to approach these problems from a grounding in critical theory. As a result of our conversations, we conclude that there is a need to reshape the field of science education to invite more unorthodox research perspectives, methodologies, and publication formats. To do so, the issues we explore require a continued conversation between emerging scholars, practicing researchers, and practicing educators.

  12. Purification and characterization of the carbonic anhydrase enzyme from Black Sea trout (Salmo trutta Labrax Coruhensis) kidney and inhibition effects of some metal ions on enzyme activity.

    PubMed

    Kucuk, Murat; Gulcin, İlhami

    2016-06-01

    In this study, the carbonic anhydrase (CA) enzyme was purified from Black Sea trout (Salmo trutta Labrax Coruhensis) kidney with a specific activity of 603.77EU/mg and a yield of 35.5% using Sepharose-4B-l-tyrosine- sulphanilamide affinity column chromatography. For determining the enzyme purity and subunit molecular mass, sodiumdodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE) was performed and single band was observed. The molecular mass of subunit was found approximately 29.71kDa. The optimum temperature, activation energy (Ea), activation enthalpy (ΔH) and Q10 values were obtained from Arrhenius plot. Km and Vmax values for p-nitrophenyl acetate of the purified enzyme were calculated from Lineweaver-Burk graphs. In addition, the inhibitory effects of different heavy metal ions (Fe(2+), Pb(2+), Co(2+), Ag(+) and Cu(2+)) on Black Sea trout kidney tissue CA enzyme activities were investigated by using esterase method under in vitro conditions. The heavy metal concentrations inhibiting 50% of enzyme activity (IC50) were obtained. Finally Ki values and inhibition types were calculated from Lineweaver-Burk graphs. PMID:27175889

  13. Density functional theory for low-energy electron-molecule scattering

    NASA Astrophysics Data System (ADS)

    Burke, Kieron; Wasserman, Adam

    2004-09-01

    Time-dependent density functional theory (TDDFT) is becoming popular as an approach to time-dependent electronic problems[1]. In the weak field regime, TDDFT predicts electronic transition frequencies and optical spectra of atoms, molecules, clusters, and solids, with an accuracy comparable to high-level wavefunction calculations at a fraction of the computational cost[2]. For large systems, TDDFT is the method of choice. Given the importance of correlation effects in low-energy electron-molecule scattering, extracting scattering amplitudes from TDDFT appears desirable. I will review this background, and outline how this can be done[3]. Detailed results will be shown by Wasserman in another talk. [1] Time-Dependent Density Functional Theory, M.A.L. Marques and E.K.U. Gross, Annu. Rev. Phys. Chem. 55, 427 (2004). [2] Time-dependent density functional theory in quantum chemistry, F. Furche and K. Burke, to appear in 1st vol. of Annu. Rev. of Computational Chemistry (2004) [3] Electron-molecule scattering from time-dependent density functional theory A. Wasserman, N.T. Maitra, and K. Burke, submitted (see http:dft.rutgers.edu/pubs/publist.html).

  14. Implicit bias against sexual minorities in medicine: cycles of professional influence and the role of the hidden curriculum.

    PubMed

    Fallin-Bennett, Keisa

    2015-05-01

    Despite many recent advances in rights for sexual and gender minorities in the United States, bias against lesbian, gay, bisexual, and transgender (LGBT) people still exists. In this Commentary, the author briefly reviews disparities with regard to LGBT health, in both health care and medical education, and discusses the implications of Burke and colleagues’ study of implicit and explicit biases against lesbian and gay people among heterosexual first-year medical students, published in this issue of Academic Medicine. Emphasis is placed on the ways in which physicians’ implicit bias against LGBT people can create a cycle that perpetuates a professional climate reinforcing the bias. The hidden curriculum in academic health centers is discussed as both a cause of this cycle and as a starting point for a research and intervention agenda. The findings from Burke and colleagues’ study, as well as other evidence, support raising awareness of LGBT discrimination, increasing exposure to LGBT individuals as colleagues and role models in academic health centers, and modifying medical education curricula as methods to break the cycle of implicit bias in medicine. PMID:25674911

  15. New Developments Regarding the KT Event and Other Catastrophes in Earth History

    NASA Astrophysics Data System (ADS)

    This volume contains papers that have been accepted for presentation at the conference on New Developments Regarding the KT Event and Other Catastrophes in Earth History, February 9-12, 1994, in Houston, Texas. The Program Committee consisted of W. Alvarez (University of California, Berkeley), D. Black (Lunar and Planetary Institute), J. Bourgeois (National Science Foundation), K. Burke (University of Houston), R. Ginsburg (University of Miami), G. Keller (Princeton University), C. Koeberl (University of Vienna), J. Longoria (Florida International University), G. Ryder (Lunar and Planetary Institute), V. Sharpton, convener (Lunar and Planetary Institute), H. Sigurdsson (University of Rhode Island), R. Turco (University of California, Los Angeles), and P. Ward (University of Washington). The Scientific Organizing Committee consisted of W. Alvarez (University of California, Berkeley), D. Black (Lunar and Planetary Institute), K. Burke (University of Houston), R. Ginsburg (University of Miami), L. Hunt (National Academy of Sciences), G. Keller (Princeton University), L. Marin (UNAM, cd. Universitaria), D. Raup (University of Chicago), V. Sharpton (Lunar and Planetary Institute), E. Shoemaker (U.S. Geological Survey, Flagstaff), and G. Suarez (UNAM, cd. Universitaria). Logistics and administrative and publications support were provided by the Publications and Program Services Department staff at the Lunar and Planetary Institute.

  16. Avian LH and FSH: comparison of several radioimmunoassays

    SciTech Connect

    Goldsmith, A.R.; Follett, B.K.

    1983-04-01

    Comparisons were made between various LH and FSH radioimmunoassays currently being used to measure avian hormones. The two LH assays were the homologous chicken system of Follett et al. (1972) and the turkey assay of Burke et al. (1979). These assays were also used in heterologous arrangement by interchanging the iodinated LH fractions and antisera. Five FSH assays were analyzed: two homologous chicken systems (Scanes et al., 1977; Sakai and Ishii, 1980) an assay based on mammalian materials (rat FSH and anti-ovine FSH antiserum, and one using labelled turkey FSH (Burke et al., 1979) with an anti-chicken FSH antiserum. The potencies of purified chicken and turkey gonadotrophin preparations and of a range of plasma samples from Japanese quail were measured in each assay. The two LH systems showed some degree of species specificity, such that chicken LH was more active than turkey LH in the chicken assay, whereas the reverse was true in the turkey LH assay. The potency estimates of the purified hormones in the various FSH assays were very consistent. The qualitative changes in plasma hormone levels were similar in all assays, although there were some differences in the magnitude of the responses.

  17. Alaskan Peninsula Cenozoic stratigraphy: stratigraphic sequences and current research

    SciTech Connect

    Allison, R.C.; Armentrout, J.M.

    1985-04-01

    Geology of the Alaska Peninsula-Island Arc and Continental Margin, by C.A. Burk, is the principal reference for stratigraphic studies on the Alaska Peninsula. Burk mapped the Phanerozoic stratigraphy and provided a geologic history and structural interpretation of the area between Wide Bay and Unimak Island. Cenozoic rocks were mapped as three unconformity-bounded sequences. Recognition of specific formations was difficult due to similarity of lithofacies, isolated outcrops, rapid facies changes, and alteration and burial by young volcanics. Consequently, megafossil assemblages were relied upon to facilitate correlations between study areas. The three unconformity-bounded Cenozoic sequences are: (1) the Paleogene Beaver Bay Group consisting of three formations: the dominantly nonmarine Tolstoi Formation, the dominantly marine Stepovak Formation, and the volcanic Meshik Formation. Current work suggests these units are at least in part coeval facies of late Paleocene through Oligocene age. (2) The Neogene Bear Lake Formation consisting of the lower Unga Conglomerate Member and an unnamed upper member. Rapid facies changes and incorrect reports of fossil occurrence have resulted in confusion of stratigraphic relationships within this sequence of middle to late Miocene age. (3) A late Neogene informally defined upper sequence consisting of interbedded marginal marine, coastal-plain, and volcanic facies. Current work suggests this sequence is Pliocene through Pleistocene in age.

  18. Norm-conserving pseudopotentials with chemical accuracy compared to all-electron calculations

    NASA Astrophysics Data System (ADS)

    Willand, Alex; Kvashnin, Yaroslav O.; Genovese, Luigi; Vázquez-Mayagoitia, Álvaro; Deb, Arpan Krishna; Sadeghi, Ali; Deutsch, Thierry; Goedecker, Stefan

    2013-03-01

    By adding a nonlinear core correction to the well established dual space Gaussian type pseudopotentials for the chemical elements up to the third period, we construct improved pseudopotentials for the Perdew-Burke-Ernzerhof [J. Perdew, K. Burke, and M. Ernzerhof, Phys. Rev. Lett. 77, 3865 (1996), 10.1103/PhysRevLett.77.3865] functional and demonstrate that they exhibit excellent accuracy. Our benchmarks for the G2-1 test set show average atomization energy errors of only half a kcal/mol. The pseudopotentials also remain highly reliable for high pressure phases of crystalline solids. When supplemented by empirical dispersion corrections [S. Grimme, J. Comput. Chem. 27, 1787 (2006), 10.1002/jcc.20495; S. Grimme, J. Antony, S. Ehrlich, and H. Krieg, J. Chem. Phys. 132, 154104 (2010), 10.1063/1.3382344] the average error in the interaction energy between molecules is also about half a kcal/mol. The accuracy that can be obtained by these pseudopotentials in combination with a systematic basis set is well superior to the accuracy that can be obtained by commonly used medium size Gaussian basis sets in all-electron calculations.

  19. Role of the Charge-Transfer State in Reduced Langevin Recombination in Organic Solar Cells: A Theoretical Study

    PubMed Central

    2015-01-01

    Reduced Langevin recombination has been observed in organic solar cells (OSCs) for many years, but its origin is still unclear. A recent work by Burke et al. (Adv. Energy Mater.2015, 5, 1500123-1) was inspired by this reduced Langevin recombination, and they proposed an equilibrium model of charge-transfer (CT) states that correlates the open-circuit voltage of OSCs with experimentally available device parameters. In this work, we extend Burke et al.’s CT model further and for the first time directly correlate the reduced Langevin recombination with the energetic and dynamic behavior of the CT state. Recombination through CT states leads in a straightforward manner to a decrease in the Langevin reduction factor with increasing temperature, without explicit consideration of the temperature dependence of the mobility. To verify the correlation between the CT states and reduced Langevin recombination, we incorporated this CT model and the reduced Langevin model into drift-diffusion simulations of a bilayer OSC. The simulations not only successfully reproduced realistic current–voltage (J–V) characteristics of the bilayer OSC, but also demonstrate that the two models consistently lead to same value of the apparent Langevin reduction factor. PMID:26640611

  20. Multifactorial inheritance with cultural transmission and assortative mating. II. a general model of combined polygenic and cultural inheritance.

    PubMed Central

    Cloninger, C R; Rice, J; Reich, T

    1979-01-01

    A general linear model of combined polygenic-cultural inheritance is described. The model allows for phenotypic assortative mating, common environment, maternal and paternal effects, and genic-cultural correlation. General formulae for phenotypic correlation between family members in extended pedigrees are given for both primary and secondary assortative mating. A FORTRAN program BETA, available upon request, is used to provide maximum likelihood estimates of the parameters from reported correlations. American data about IQ and Burks' culture index are analyzed. Both cultural and genetic components of phenotypic variance are observed to make significant and substantial contributions to familial resemblance in IQ. The correlation between the environments of DZ twins is found to equal that of singleton sibs, not that of MZ twins. Burks' culture index is found to be an imperfect measure of midparent IQ rather than an index of home environment as previously assumed. Conditions under which the parameters of the model may be uniquely and precisely estimated are discussed. Interpretation of variance components in the presence of assortative mating and genic-cultural covariance is reviewed. A conservative, but robust, approach to the use of environmental indices is described. PMID:453202

  1. Overview of energy-conserving development planning and design techniques based on five case studies

    SciTech Connect

    Not Available

    1980-06-01

    Findings and recommendations are presented of a review of five case studies of ways to conserve energy through development planning and site design in communities. Two approaches were used. In the first approach, a conventional, pre-existing plan was analyzed to determine potential energy use. Once energy-conservation options were identified and evaluated, the conventional plan was modified by employing those options. This approach was used in The Woodlands, Burke Center, and Radisson studies. In the second approach, energy-conservation options are independently identified and evaluated. Those options that passed specific criteria screening were then utilized in developing one or more totally new plans based on energy objectives. This approach was used in Greenbrier and Shenandoah. Radisson is a new town on the outskirts of Syracuse, New York. Greenbrier is a 3000 acre planned community adjacent to Norfolk and Virginia Beach. Shenandoah is a proposed new town in the Atlanta urbanized area. The Woodlands is a new community under development north of Houston. Burke Center is a residential planned unit development in Fairfax County, Virgnia. (MCW)

  2. Calosota Curtis (Hymenoptera, Chalcidoidea, Eupelmidae) – review of the New World and European fauna including revision of species from the West Indies and Central and North America

    PubMed Central

    Gary A.P., Gibson

    2010-01-01

    Abstract Two of three species previously classified in Calosota Curtis (Hymenoptera: Eupelmidae) from the Neotropical region are transferred to Eupelminae. Calosota eneubulus (Walker) from Galapagos Islands is transferred to Eupelmus Dalman as Eupelmus (Eupelmus) eneubulus (Walker), comb. n., and Calosota silvai (Brèthes) from Chile is transferred to Brasema Cameron as Brasema silvai comb. n. Calosota cecidobius (Kieffer) from Argentina is retained in Calosota, with reservation, as an unrecognized species. The species of Calosota from the New World excluding South America are revised. Eleven species are recognized, including the seven newly described species Calosota albipalpus sp. n. (Costa Rica, Mexico, USA, Venezuela), Calosota bicolorata sp. n. (USA), Calosota elongata sp. n. (USA), Calosota longivena sp. n. (USA), Calosota panamaensis sp. n. (Panama), Calosota setosa sp. n. (Bahamas, Dominican Republic, USA), and Calosota speculifrons sp. n. (Costa Rica, USA). The 11 regional species and the Palaearctic species Calosota vernalis Curtis are keyed and illustrated. Calosota vernalis is not known to occur in the New World but is included in the key and diagnosed because it has been intercepted in quarantine in Canada. Calosota pseudotsugae Burks is placed in synonymy under Calosota acron (Walker), syn. n.,and Calosota kentra Burks, Calosota montana Burks and Calosota septentrionalis Hedqvist are placed in synonymy under Calosota aestivalis Curtis syn. n. Calosota modesta Bolívar y Pieltain is removed from synonymy under Calosota viridis Masi, stat. rev., and Calosota viridis, Calosota matritensis Bolívar y Pieltain, and Calosota coerulea Nikol’skaya are placed in synonymy under Calosota metallica (Gahan), syn. n. Calosota grylli Erdös is confirmed as a separate species from Calosota metallica based on features of both sexes. It is suggested that Calosota ariasi Bolívar y Pieltain may be a synonym of Calosota aestivalis, Calosota bolivari Askew may be a

  3. Infrared spectra of interstellar deuteronated PAHs

    NASA Astrophysics Data System (ADS)

    Buragohain, Mridusmita; Pathak, Amit; Sarre, Peter

    2015-08-01

    Polycyclic Aromatic Hydrocarbon (PAH) molecules have emerged as a potential constituent of the ISM that emit strong features at 3.3, 6.2, 7.7, 8.6, 11.2 and 12.7 μm with weaker and blended features in the 3-20μm region. These features are proposed to arise from the vibrational relaxation of PAH molecules on absorption of background UV photons (Tielens 2008). These IR features have been observed towards almost all types of astronomical objects; say H II regions, photodissociation regions, reflection nebulae, planetary nebulae, young star forming regions, external galaxies, etc. A recent observation has proposed that interstellar PAHs are major reservoir for interstellar deuterium (D) (Peeters et al. 2004). According to the `deuterium depletion model' as suggested by Draine (2006), some of the Ds formed in the big bang are depleted in PAHs, which can account for the present value of D/H in the ISM. Hence, study of deuterated PAHs (PADs) is essential in order to measure D/H in the ISM.In this work, we consider another probable category of the large PAH family, i.e. Deuteronated PAHs (DPAH+). Onaka et al. have proposed a D/H ratio which is an order of magnitude smaller than the proposed value of D/H by Draine suggesting that if Ds are depleted in PAHs, they might be accommodated in large PAHs (Onaka et al. 2014). This work reports a `Density Functional Theory' calculation of large deuteronated PAHs (coronene, ovalene, circumcoronene and circumcircumcoronene) to determine the expected region of emission features and to find a D/H ratio that is comparable to the observational results. We present a detailed analysis of the IR spectra of these molecules and discuss the possible astrophysical implications.ReferencesDraine B. T. 2006, in ASP Conf. Ser. 348, Proc. Astrophysics in the Far Ultraviolet: Five Years of Discovery with FUSE, ed. G. Sonneborn, H. Moos, B-G Andersson (San Francisco, CA:ASP) 58Onaka T., Mori T. I., Sakon I., Ohsawa R., Kaneda H., Okada Y., Tanaka M

  4. Cavity Ringdown Spectroscopy and Kinetics of HO_2+HCHO: Detection of the ν_1 and {A}- {X} Bands of HOCH_2OOCAVITY Ringdown Spectroscopy and Kinetics of HO_2+HCHO: Detection of the ν_1 and {A}- {X} Bands of HOCH_2OO

    NASA Astrophysics Data System (ADS)

    Sprague, Matthew K.; Okumura, Mitchio; Sander, Stanley P.

    2011-06-01

    The reactions of HO_2 with carbonyl compounds are believed to be a sink for carbonyl compounds in the upper troposphere and lower stratosphere. These reactions proceed through a hydrogen bound intermediate before isomerizing. The reaction of HO_2 + formaldehyde (HCHO) serves as a prototype for this class of reactions, forming the isomerization product hydroxymethylperoxy (HOCH_2OO, HMP). Previous studies measured the spectrum and kinetics of HMP using either FTIR detection of the end products or direct detection of HMP by the unstructured tilde{B}-tilde{X} transition. Despite these studies, considerable uncertainty exists in the rate constant of HMP formation (±80%, 2σ). In this talk, we report the first detection of the ν_1 (OH stretch) and tilde{A}-tilde{X} electronic spectra of the HMP radical. The OH stretch spectrum is broad and featureless, while the tilde{A}(0)-tilde{X}(0) origin and combination band with the OOCO torsion tilde{A}(NOOCO=1)-tilde{X}(0) are rotationally resolved. Quantum chemistry calculations have been performed on both the tilde{A} and tilde{X} states as a function of the OOCO and HOCO dihedral angles to estimate the tilde{A}-tilde{X} transition frequency and to assess the coupling between the two torsional modes. We also present kinetics data showing the rates of production and destruction of HMP. I. Hermans, J. F. Muller, T. L. Nguyen, P. A. Jacobs, and J. Peeters. J. Phys. Chem. A 2005, 109, 4303. F. Su, J. G. Calvert, and J. H. Shaw J. Phys. Chem. 1979, 83, 3185. B. Veyret, R. Lesclaux, M. T. Rayez, J. C. Rayez, R. A. Cox, and G. K. Moortgat J. Phys. Chem. 1989, 93, 2368. J. P. Burrows, G. K. Moortgat, G. S. Tyndall, R. A. Cox, M. E. Jenkin, G. D. Hayman, and B. Veyret J. Phys. Chem. 1989, 93, 2375 S. P. Sander, B. J. Finlayson-Pitts, D. M. Golden, R. E. Huie, C. E. Kolb, M. J. Kurylo, M. J. Molina, et al. Chemical Kinetics and Photochemical Data for Use in Atmospheric Studies, Evaluation Number 16, Jet Propulsion Laboratory, 2009 I

  5. Past changes of landscape due to increased dynamics of erosion processes in the Bezděz-Doksy region (Czech Republic)

    NASA Astrophysics Data System (ADS)

    Vysloužilová, Barbora; Dreslerová, Dagmar; Kozáková, Radka; Poništiak, Štefan; Chuman, Tomáš; Šefrna, Luděk

    2016-04-01

    This study broadens the archaeological research of the the Bezděz - Doksy region in Northern Bohemia, Czech Republic (Dreslerová et al., 2013). Extensive field works between 2008 and 2012 showed that the region has been settled since the La Tène period. Survey of the alluvial plain of the Robečský stream revealed a record of two intensive erosion episodes in the catchment. We suppose that the first episode may be connected to land use changes and the beginnings of agriculture at the site in the La Tène period. The second episode may be connected to the foundation of the medieval village of Okna, which came into existence in the vicinity of the La Tène settlement. The accelerated erosion of former albeluvisols (on loess) led to significant changes of landscape in the region. The aim of this contribution is to bring a reconstruction of soils, vegetation and relief at the site of Okna before the human occupancy and to detect landscape changes over the time. It focuses on the hypothesis that the accelerated soil erosion has been occurring at the site since the first anthropogenic influence like it is demonstrated by other studies in Europe (e.g. Leopold and Völkel, 2007; Boardman, 2013). An abrupt change of land use from forest to arable land is proved by palynological records. Simultaneously there are buried soil horizons and alluvial sediments which can be studied as geoarchives. The difficulties in reconstruction of relief and quantification of the historical erosion effects are faced by applying GIS and model approaches (Peeters et al., 2003). References Boardman, J., 2013. Soil Erosion in Britain: Updating the Record. Agriculture 3, 418-442. doi:10.3390/agriculture3030418 Dreslerová, D., Waldhauser, J., Abraham, V., Kočár, P., Křivánek, R., Meduna, P., Sádlo, J., 2013. The Bezděz - Doksy region (Northern Bohemia) in prehistory and the La Tène settlement at Okna (in Czech). Archeologické rozhledy LXV, 535-573. Leopold, M., Völkel, J., 2007

  6. Magnetism in zigzag and armchair CuO nanotubes: Ab-initio study

    NASA Astrophysics Data System (ADS)

    Paudel, Samir; Dandeliya, Sushmita; Chaurasiya, Rajneesh; Srivastava, Anurag; Kaphle, Gopi Chandra

    2016-05-01

    The structural stability, electronic band structure and magnetic properties of zigzag (4≤n≤12) and armchair (3≤n≤8) copper oxide nanotubes have been analyzed by employing a standard Density Functional Theory based ab-intio approach using spin polarized generalized gradient approximation with revised Perdew Burke Ernzerhoff type parameterization. The binding energy of both zigzag as well as armchair CuO nanotubes increases with increasing diameter. Whereas, calculated total magnetic moment decreases with increasing diameter. Among the considered chiralities, (5, 5) armchair (diameter 9.08 Å) and (9, 0) zigzag (diameter 9.47 Å) CuO nanotubes show highest degree of spin polarization, however total magnetic moment is found to be highest for (4, 0) zigzag and (3, 3) armchair CuO nanotubes. The computed electronic properties of considered CuO Nanotube, confirms the metallic nature of these nanotubes.

  7. First-principles study of Cu2ZnSnS4 and the related band offsets for photovoltaic applications.

    PubMed

    Nagoya, A; Asahi, R; Kresse, G

    2011-10-12

    First-principles calculations of the band offsets between Cu(2)ZnSnS(4) (CZTS) and XS (X = Cd, Zn) are performed. While the interface dipole contribution for the band offsets is calculated using the Perdew-Burke-Ernzerhof functional, the Heyd-Scuseria-Ernzerhof hybrid functional is employed to introduce the quasiparticle corrections to the band offsets. The calculated conduction band offset between CZTS and CdS is 0.2 eV, validating CdS for the buffer layer of the CZTS solar cell. The small conduction band offset stems from the band gap narrowing of CdS under the interface strain caused by the lattice misfit with CZTS. A large valence band offset over 0.9 eV between CZTS and ZnS indicates that precipitated ZnS is regarded as an inactive insulator phase in CZTS absorbers. PMID:21931185

  8. Inhibitory effect of methanol extract of Rosa damascena Mill. flowers on alpha-glucosidase activity and postprandial hyperglycemia in normal and diabetic rats.

    PubMed

    Gholamhoseinian, A; Fallah, H; Sharifi far, F

    2009-10-01

    The effect of a methanol extract of Rosa damascena Mill. flowers was studied, in comparison to the alpha-glucosidase inhibitor acarbose, in normal and diabetic rats. The inhibition mode of this extract was examined by measuring enzyme activity in different concentrations of substrate for Lineweaver-Burk plot analysis. The results show that Rosa damascena extract has an intensive inhibitory effect on alpha-glucosidase. Its inhibition was found to be noncompetitive. Oral administration of this plant extract (100 to 1000 mg/kg body wt.) significantly decreased blood glucose after maltose loading in normal and diabetic rats in a dose-dependent manner. These results suggest that Rosa damascena might exert an anti-diabetic effect by suppressing carbohydrate absorption from the intestine and can reduce the postprandial glucose level. PMID:19380218

  9. New directions in the use of virtual reality for food shopping: marketing and education perspectives.

    PubMed

    Ruppert, Barb

    2011-03-01

    Virtual reality is used in marketing research to shape food selection and purchase decisions. Could it be used to counteract the marketing of less-nutritious foods and teach healthier food selection? This article presents interviews with Raymond Burke, Ph.D., of Indiana University Bloomington, and Rachel Jones, M.P.H., of the University of Utah College of Health. Topics covered include new marketing research technologies, including virtual reality simulations; retailing and shopper behavior; and the use of virtual grocery stores to help students explore quality of diet and food/nutrient relationships. The interviewees discuss how the technologies they have developed fit into research and behavior change related to obesity and diabetes. PMID:21527099

  10. Comparison of HfCl4, HfI4, TEMA-Hf, and TDMA-Hf as precursors in early growing stages of HfO2 films deposited by ALD: A DFT study

    NASA Astrophysics Data System (ADS)

    Cortez-Valadez, M.; Fierro, C.; Farias-Mancilla, J. R.; Vargas-Ortiz, A.; Flores-Acosta, M.; Ramírez-Bon, R.; Enriquez-Carrejo, J. L.; Soubervielle-Montalvo, C.; Mani-Gonzalez, P. G.

    2016-06-01

    The final structure of HfO2 films grown by atomic layer deposition (ALD) after reaction with OH- ions has been analyzed by DFT (density functional theory). The interaction of the precursors: HfCl4 (hafnium tetrachloride), HfI4 (hafnium tetraiodide), TEMA-Hf (tetrakis-ethylmethylamino hafnium), and TDMA-Hf (tetrakis-dimethylamino hafnium) with HO-H was studied employing the B3LYP (Becke 3-parameter, Lee-Yang-Parr) hybrid functional and the PBE (Perdew-Burke-Ernzerhof) generalized gradient functional. The structural evolution at the Si(100) surface has been analyzed by LDA (local density approximation). The structural parameters: bond length and bond angle, and the vibrational parameters for the optimized structures are also reported. The presence of hafnium silicate at the interface was detected. The infrared spectra and structural parameters obtained in this work agree with previously reported experimental results.

  11. Effects of some metal ions on rainbow trout erythrocytes glutathione S-transferase enzyme: an in vitro study.

    PubMed

    Comakli, Veysel; Ciftci, Mehmet; Kufrevioglu, O Irfan

    2013-12-01

    Glutathione S-transferase enzyme (GST) (EC 2.5.1.18) was purified from rainbow trout erythrocytes, and some characteristics of the enzyme and effects of some metal ions on enzyme activity were investigated. For this purpose, erythrocyte glutathione S-transferase enzyme which has 16.54 EU/mg protein specific activities was purified 11,026-fold by glutathione-agarose affinity chromatography with a yield of 59%. Temperature was kept under control (+4°C) during purification. Enzyme purification was checked by performing SDS-PAGE. Optimal pH, stable pH, optimal temperature, and K(M) and Vmax values for GSH and 1-chloro-2, 4-dinitrobenzene (CDNB) were also determined for the enzyme. In addition, IC50 values, Ki constants and the type of inhibition were determined by means of Line-Weaver-Burk graphs obtained for such inhibitors as Ag(+); Cd(2+), Cr(2+) and Mg(2+). PMID:23057421

  12. Managing crises through organisational development: a conceptual framework.

    PubMed

    Lalonde, Carole

    2011-04-01

    This paper presents a synthesis of the guiding principles in crisis management in accordance with the four configurational imperatives (strategy, structure, leadership and environment) defined by Miller (1987) and outlines interventions in organisational development (OD) that may contribute to their achievement. The aim is to build a conceptual framework at the intersection of these two fields that could help to strengthen the resilient capabilities of individuals, organisations and communities to face crises. This incursion into the field of OD--to generate more efficient configurations of practices in crisis management--seems particularly fruitful considering the system-wide application of OD, based on open-systems theory (Burke, 2008). Various interventions proposed by OD in terms of human processes, structural designs and human resource management, as well as strategy, may help leaders, members of organisations and civil society apply effectively, and in a more sustainable way, the crisis management guiding principles defined by researchers. PMID:21083850

  13. Report of the Working Design Group

    NASA Technical Reports Server (NTRS)

    1992-01-01

    The engineering study group in the LOUISA workshop was responsible for producing a preliminary general design for an optical synthetic aperture telescope on the Moon. This design is intended to be a test case for focusing continuing design studies. The scope of the design included consideration of the array geometry, individual telescopes, metrology, site attributes, and construction. However, no attempt was made to go into further depth in the design than to cover the essential characteristics of the instrument. The starting point for the array design was the lunar optical array discussed by Burke (1985). His array geometry followed the design and correlation procedure of the 27-element Very Large Array (VLA) radio telescopes near Socorro, New Mexico.

  14. Mad Men as health communication: health-related themes in the hit AMC television series.

    PubMed

    Baglia, Jay; Foster, Elissa

    2015-01-01

    As a popular contemporary text, the appeal of cable television's Mad Men (AMC) lies in its capacity to highlight the differences between 1960s sensibilities and 21st-century assumptions. Viewers can enjoy a sense of superiority by recognizing the "folly" of the beliefs and actions of the characters with the benefit of historic hindsight, as well as noting the evolution of technology, philosophy, and human rights. Health-related scenes and themes in the series are a particularly interesting focus for analysis. We employ Burke's four master tropes as an analytical lens and argue that the dominant dramatic technique of irony, particularly in the form that we call strategic anachronism-derived from an audience's enjoyment of historical hindsight-highlights the racism, sexism, homophobia, and overall conservatism of the early 1960s while simultaneously serving to obfuscate the ways in which we still have much to critique in the delivery of contemporary health care and other body politics. PMID:24483343

  15. Monitoring enzyme kinetic behavior of enzyme-quantum dot bioconjugates

    NASA Astrophysics Data System (ADS)

    Claussen, Jonathan C.; Walper, Scott A.; Susumu, Kimihiro; Ancona, Mario G.; Medintz, Igor L.

    2014-05-01

    Luminescent semiconductor nanocrystals or quantum dots (QDs) hold tremendous promise for in vivo biosensing, cellular imaging, theranostics, and smart molecular sensing probes due to their small size and favorable photonic properties such as resistance to photobleaching, size-tunable PL, and large effective Stokes shifts. Herein, we demonstrate how QD-based bioconjugates can be used to enhance enzyme kinetics. Enzyme-substrate kinetics are analyzed for solutions containing both alkaline phosphatase enzymes and QDs with enzyme-to- QD molar ratios of 2, 12, and 24 as well as for a solution containing the same concentration of enzymes but without QDs. The enzyme kinetic paramters Vmax, KM, and Kcat/KM are extracted from the enzyme progress curves via the Lineweaver-Burk plot. Results demonstrate an approximate increase in enzyme efficiency of 5 - 8% for enzymes immobilized on the QD versus free in solution without QD immobilization.

  16. Forchlorfenuron detection based on its inhibitory effect towards catalase immobilized on boron nitride substrate.

    PubMed

    Xu, Qin; Cai, Lijuan; Zhao, Huijie; Tang, Jiaqian; Shen, Yuanyuan; Hu, Xiaoya; Zeng, Haibo

    2015-01-15

    An enzymatic procedure based on a catalase biosensor for the detection of forchlorfenuron (CPPU) has been reported in this work. Catalase was immobilized on boron nitride (BN) sheets dispersed in chitosan by adsorption. The immobilized catalase exhibited direct electron transfer character and excellent electrocatalytic activity towards H2O2 reduction. After introducing CPPU into the H2O2 containing phosphate buffer solution, the catalase-catalyzed H2O2 reduction current decreased. By measuring the current decrease, CPPU can be determined in the range of 0.5-10.0 µM with the detection limit of 0.07 μM. The non-competitive inhibition behavior of CPPU towards catalase was verified by the Lineweaver-Burk plots. Long stability character has been ascribed to this biosensor. Possible use of this biosensor in flow systems is illustrated. The proposed biosensor has been successfully applied to CPPU determination in fruits samples with satisfactory results. PMID:25108110

  17. Stability Analysis of TiN, ZrN and HfN: An ab-initio Study

    NASA Astrophysics Data System (ADS)

    Gupta, Dinesh; Chauhan, Mamta

    2013-06-01

    In the present study density functional theory has been applied to analyze the stability of Titanium nitride, Zirconium nitride and Hafnium nitride in their zinc blende (B3), rocksalt (B1) and CsCl (B2)-type phases. The ground state total energy calculation approach of the system has been used through generalized gradient approximation (GGA) with Perdew-Burke-Ernzerhof (PBE) type parameterization as exchange correlation functional within the framework of SIESTA code. Stability analyses shows that the B1 phase of these nitrides is more stable as compared to the B3 and B2 phases and follows the stability trend as B1 -->B3 -->B2. The authors acknowledge financial support to this work by UGC and DST, New Delhi.

  18. A novel angiotensin-І converting enzyme (ACE) inhibitory peptide from gastrointestinal protease hydrolysate of silkworm pupa (Bombyx mori) protein: Biochemical characterization and molecular docking study.

    PubMed

    Wu, Qiongying; Jia, Junqiang; Yan, Hui; Du, Jinjuan; Gui, Zhongzheng

    2015-06-01

    Silkworm pupa (Bombyx mori) protein was hydrolyzed using gastrointestinal endopeptidases (pepsin, trypsin and α-chymotrypsin). Then, the hydrolysate was purified sequentially by ultrafiltration, gel filtration chromatography and RP-HPLC. A novel ACE inhibitory peptide, Ala-Ser-Leu, with the IC50 value of 102.15μM, was identified by IT-MS/MS. This is the first report of Ala-Ser-Leu from natural protein. Lineweaver-Burk plots suggest that the peptide is a competitive inhibitor against ACE. The molecular docking studies revealed that the ACE inhibition of Ala-Ser-Leu is mainly attributed to forming very strong hydrogen bonds with the S1 pocket (Ala354) and the S2 pocket (Gln281 and His353). The results indicate that silkworm pupa (B. mori) protein or its gastrointestinal protease hydrolysate could be used as a functional ingredient in auxiliary therapeutic foods against hypertension. PMID:25111373

  19. The distribution of period ratios in Kepler planetary systems

    NASA Astrophysics Data System (ADS)

    Steffen, Jason H.; Hwang, Jason A.

    2015-01-01

    Kepler's multi-planet systems are a valuable tool to understand the architectures and dynamics of the inner parts of planetary systems. I present an analysis of the distribution of orbital period ratios from candidate systems identified in the Quarter 8 catalog (Burke et al. 2014). This distribution is corrected for the effects of geometric transit probabilities and the completeness of the data reduction pipeline. We find that the distribution of period ratios falls as a power law with exponent -1.26 ± 0.05. We also identify a new, statistically significant feature near a period ratio of 2.2. These observations may provide insights into the formation and evolution of these systems.

  20. Magic, Mind Control, and the Body Electric: "Materia Medica" in Sir Walter Scott's Library at Abbotsford.

    PubMed

    Levy, Lindsay

    2014-01-01

    This chapter examines the medical texts, or "Materia Medica", held by Sir Walter Scott in his library at Abbotsford. While the vast majority of Scott's medical texts are antiquarian, his library also contains rare tracts and ephemera relating to the medical practice of the infamous quack, Dr James Graham (1745-94), and the Burke and Hare controversy of 1828 and its aftermath. Examining Scott's holdings of medical texts in relation to his own health and that of his family and friends, it is argued that the lack of contemporary medical self-help texts in his library is striking and indicative of his stoical attitude towards health, despite his clear interest in medical culture. PMID:27132356

  1. Analysis of the structural, electronic and optic properties of Ni doped MgSiP2 semiconductor chalcopyrite compound

    NASA Astrophysics Data System (ADS)

    Kocak, Belgin; Ciftci, Yasemin Oztekin

    2016-03-01

    The structural, electronic band structure and optic properties of the Ni doped MgSiP2 chalcopyrite compound have been performed by using first-principles method in the density functional theory (DFT) as implemented in Vienna Ab-initio Simulation Package (VASP). The generalized gradient approximation (GGA) in the scheme of Perdew, Burke and Ernzerhof (PBE) is used for the exchange and correlation functional. The present lattice constant (a) follows generally the Vegard's law. The electronic band structure, total and partial density of states (DOS and PDOS) are calculated. We present data for the frequency dependence of imaginary and real parts of dielectric functions of Ni doped MgSiP2. For further investigation of the optical properties the reflectivity, refractive index, extinction coefficient and electron energy loss function are also predicted. Our obtained results indicate that the lattice constants, electronic band structure and optical properties of this compound are dependent on the substitution concentration of Ni.

  2. Measuring kinetic coefficients by molecular dynamics simulation of zone melting

    NASA Astrophysics Data System (ADS)

    Celestini, Franck; Debierre, Jean-Marc

    2002-04-01

    Molecular dynamics simulations are performed to measure the kinetic coefficient at the solid-liquid interface in pure gold. Results are obtained for the (111), (100), and (110) orientations. Both Au(100) and Au(110) are in reasonable agreement with the law proposed for collision-limited growth. For Au(111), stacking fault domains form, as first reported by Burke, Broughton, and Gilmer [J. Chem. Phys. 89, 1030 (1988)]. The consequence on the kinetics of this interface is dramatic: the measured kinetic coefficient is three times smaller than that predicted by collision-limited growth. Finally, crystallization and melting are found to be always asymmetrical and here again the effect is much more pronounced for the (111) orientation.

  3. A novel strategy with standardized reference extract qualification and single compound quantitative evaluation for quality control of Panax notoginseng used as a functional food.

    PubMed

    Li, S P; Qiao, C F; Chen, Y W; Zhao, J; Cui, X M; Zhang, Q W; Liu, X M; Hu, D J

    2013-10-25

    Root of Panax notoginseng (Burk.) F.H. Chen (Sanqi in Chinese) is one of traditional Chinese medicines (TCMs) based functional food. Saponins are the major bioactive components. The shortage of reference compounds or chemical standards is one of the main bottlenecks for quality control of TCMs. A novel strategy, i.e. standardized reference extract based qualification and single calibrated components directly quantitative estimation of multiple analytes, was proposed to easily and effectively control the quality of natural functional foods such as Sanqi. The feasibility and credibility of this methodology were also assessed with a developed fast HPLC method. Five saponins, including ginsenoside Rg1, Re, Rb1, Rd and notoginsenoside R1 were rapidly separated using a conventional HPLC in 20 min. The quantification method was also compared with individual calibration curve method. The strategy is feasible and credible, which is easily and effectively adapted for improving the quality control of natural functional foods such as Sanqi. PMID:23910599

  4. Generalized gradient approximation to the angle- and system-averaged exchange hole

    NASA Astrophysics Data System (ADS)

    Ernzerhof, Matthias; Perdew, John P.

    1998-09-01

    A simple analytic model is proposed for the angle- and system-averaged exchange hole of a many-electron system. The model hole depends on the local density and density gradient. It recovers a nonoscillatory local-spin density (LSD) approximation to the exchange hole for a vanishing density gradient. The model hole reproduces the exchange energy density of the Perdew-Burke-Ernzerhof (PBE) generalized gradient approximation (GGA) for exchange, and facilitates a detailed understanding of the PBE GGA. The hole model is applied to atoms and molecules, and a comparison is made to exact and LSD angle- and system-averaged exchange holes. We find that the GGA hole model significantly improves upon the LSD model. Furthermore, the GGA hole model accurately describes the change in the exchange hole upon the formation of single bonds, but is less accurate for the formation of multiple bonds, where it misses the appearance of a long-range tail.

  5. Kinetic energy density dependent approximations to the exchange energy

    NASA Astrophysics Data System (ADS)

    Ernzerhof, Matthias; Scuseria, Gustavo E.

    1999-07-01

    Two nonempirical kinetic energy density dependent approximations are introduced. First, the local τ approximation (LTA) is proposed in which the exchange energy Ex depends only on a kinetic energy density τ. This LTA scheme appears to be complementary to the local spin density (LSD) approximation in the sense that its exchange contribution to the atomization energy ΔEx=Exatoms-Exmolecule is fairly accurate for systems where LSD fails. On the other hand, in cases where LSD works well LTA results for ΔEx are worse. Secondly, the τPBE approximation to Ex is developed which combines some of the advantages of LTA and of the Perdew-Burke-Ernzerhof (PBE) exchange functional. Like the PBE exchange functional, τPBE is free of empirical parameters. Furthermore, it yields improved atomization energies compared to the PBE approximation.

  6. Structure, electronic and magnetic properties of Mnn (n=2-8) clusters: A DFT investigation

    NASA Astrophysics Data System (ADS)

    Kumar, Vipin; Roy, Debesh R.

    2016-05-01

    A detail studyon the stability, electronic and magnetic properties of Mnn (n=2-8) cluster series is performed under the utilization ofdensity functional theory (DFT). The binding energy (B.E.), HOMO-LUMO energy gap (HLG), chemical hardness (η), ionization potential (I.P.), electron affinity (E.A)and electronegativity (χ) of these clusters are predicted. We have also studied the magnetic moments associated with the stable cluster isomers. The lowest energy structures for each cluster sizes aredetermined with a systematic search imposing all possible initial magnetic configuration on the cluster. All the calculations are carried out using a popular GGA functional PBE as proposed by Pardew, Burke and Ernzerhof and implemented in the VASP program.

  7. Stable half-metallic monolayers of FeCl{sub 2}

    SciTech Connect

    Torun, E. Sahin, H.; Singh, S. K.; Peeters, F. M.

    2015-05-11

    The structural, electronic, and magnetic properties of single layers of Iron Dichloride (FeCl{sub 2}) were calculated using first principles calculations. We found that the 1T phase of the single layer FeCl{sub 2} is 0.17 eV/unit cell more favorable than its 1H phase. The structural stability is confirmed by phonon calculations. We found that 1T-FeCl{sub 2} possess three Raman-active (130, 179, and 237 cm{sup −1}) and one infrared-active (279 cm{sup −1}) phonon branches. The electronic band dispersion of the 1T-FeCl{sub 2} is calculated using both gradient approximation of Perdew-Burke-Ernzerhof and DFT-HSE06 functionals. Both functionals reveal that the 1T-FeCl{sub 2} has a half-metallic ground state with a Curie temperature of 17 K.

  8. A theoretical study of a laminar diffusion flame

    NASA Technical Reports Server (NTRS)

    Frair, K. L.

    1978-01-01

    Theoretical models of an axisymmetric laminar diffusion flame are discussed, with an emphasis on the behavior of such flames at increasing pressures. The flame-sheet or Burke-Schumann model (in terms of Bessel functions) and various boundary layer numerical solutions are presented and their results compared with experimental data. The most promising theoretical model combines the numerical flow field solution of the Patankar-Spalding computer code with the Pratt-Wormeck chemical reaction subroutine. The flame shapes for pressures of 1, 5, 10, 20, and 50 atmospheres were computed and agree remarkably well with experimental data. There is a noticeable shape change with pressure, believed to be a result of buoyancy effects. The chemical concentration profiles do not exhibit much dependence on pressure, a reflection of the fact that only one chemical mechanism was utilized at all pressures.

  9. Design, synthesis and evaluation of 4-dimethylamine flavonoid derivatives as potential multifunctional anti-Alzheimer agents.

    PubMed

    Luo, Wen; Wang, Ting; Hong, Chen; Yang, Ya-Chen; Chen, Ying; Cen, Juan; Xie, Song-Qiang; Wang, Chao-Jie

    2016-10-21

    A new series of 4-dimethylamine flavonoid derivatives were designed and synthesized as potential multifunctional anti-Alzheimer agents. The inhibition of cholinesterase activity, self-induced β-amyloid (Aβ) aggregation, and antioxidant activity by these derivatives was investigated. Most of the compounds exhibited potent acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activity. A Lineweaver-Burk plot and molecular modeling study showed that these compounds targeted both the catalytic active site (CAS) and peripheral anionic site (PAS) of AChE. The derivatives showed potent self-induced Aβ aggregation inhibition and peroxyl radical absorbance activity. Moreover, compound 6d significantly protected PC12 neurons against H2O2-induced cell death at low concentrations. Thus, these compounds could become multifunctional agents for further development for the treatment of AD. PMID:27343850

  10. Asymptotic analysis with reduced chemistry for the burning of n-heptane droplets

    NASA Technical Reports Server (NTRS)

    Card, J. M.; Williams, F. A.

    1992-01-01

    The method of rate-ratio asymptotics is used with reduced chemistry to analyze the flame structure and extinction of an isolated n-heptane droplet burning under quasisteady, spherically symmetrical conditions. The outer transport zones are described by the classical Burke-Schumann solution. The inner reaction zone consists of a thin layer, on the rich side of the flame, where the fuel is consumed, and on the lean side, a broader but still asymptotically thin oxidation layer, where H2 and CO are consumed. Special attention is given to differences in predictions of extinction conditions, caused by different chemical-kinetic approximations in the reduced chemistry, including fuel-chemistry effects through molecules containing more than one carbon atom. From the analysis, extinction diameters for n-heptane droplets are estimated for different pressures and ambient oxygen concentrations. The results show that extinction diameters are extremely sensitive to the number of radicals consumed in breaking down each fuel molecule.

  11. Electronic structure study of TiB{sub 2} and Ti{sub 2}B

    SciTech Connect

    Vashistha, M. Vyas, V.; Kabra, K.; Sharma, G.

    2015-06-24

    In this paper, the electronic properties of TiB{sub 2} and Ti{sub 2}B are computed within the framework of Density Functional Theory (DFT) based on Linear Combination of Atomic Orbitals (LCAO) method. In the present calculations, the generalized gradient approximation (GGA) proposed by Perdew-Burke-Erenzerhof (PBE) and Becke’s scheme are considered to treat the correlation and exchange effects respectively. TiB{sub 2} crystallizes in the hexagonal AlB{sub 2} type structure which is designated as C32 with the space group P6/mmm. While the crystal structure of Ti{sub 2}B described in this paper is isomorphous to the body centered tetragonal (Al{sub 2}Cu - type) structure with space group I4/mcm.

  12. Finding the Big Bang

    NASA Astrophysics Data System (ADS)

    Peebles, P. James E.; Page, Lyman A., Jr.; Partridge, R. Bruce

    2009-03-01

    1. Introduction; 2. A guide to modern cosmology; 3. Origins of the cosmology of the 1960s; 4. Recollections of the 1960s Dave Hogg, Neville Woolf, George B. Field, Patrick Thaddeus, Donald E. Osterbrock, Yuri Nikolaevich Smirnov, Igor Dmitriyevich Novikov, Andrei Georgievich Doroshkevich, Rashid Alievich Sunyaev, Malcolm S. Longair, Arno Penzias, Robert W. Wilson, Bernard F. Burke, Kenneth C. Turner, P. James E. Peebles, David T. Wilkinson, Peter G. Roll, R. Bruce Partridge, Malcolm S. Longair, John Faulkner, Robert V. Wagoner, Martin Rees, Geoffrey R. Burbidge, Jayant V. Narlikar, David Layzer, Michele Kaufman, Jasper V. Wall, John Shakeshaft, William Welch, Kazimir S. Stankevich, Paul Boynton, Robert A. Stokes, Martin Harwit, Judith L. Pipher, Kandiah Shivanandan, Rainer Weiss, Jer-tsang Yu, Rainer K. Sachs, Arthur M. Wolfe, Joe Silk, George F. R. Ellis, Ronald N. Bracewell, Edward K. Conklin, Stephen Boughn, Karl C. Davis, Paul S. Henry; 5. Cosmology and the CMBR since the 1960s Dick Bond; Appendixes; Glossary; References; Index.

  13. Crystal structure of ammonia dihydrate II.

    PubMed

    Griffiths, Gareth I G; Fortes, A Dominic; Pickard, Chris J; Needs, R J

    2012-05-01

    We have used density-functional-theory (DFT) methods together with a structure searching algorithm to make an experimentally constrained prediction of the structure of ammonia dihydrate II (ADH-II). The DFT structure is in good agreement with neutron diffraction data and verifies the prediction. The structure consists of the same basic structural elements as ADH-I, with a modest alteration to the packing, but a considerable reduction in volume. The phase diagram of the known ADH and ammonia monohydrate + water-ice structures is calculated with the Perdew-Burke-Ernzerhof density functional, and the effects of a semi-empirical dispersion corrected functional are investigated. The results of our DFT calculations of the finite-pressure elastic constants of ADH-II are compared with the available experimental data for the elastic strain coefficients. PMID:22583254

  14. Curious afterlives: the enduring appeal of the criminal corpse

    PubMed Central

    Tarlow, Sarah

    2016-01-01

    Abstract Not only did the criminal corpse have actual medicinal and magical power for Europeans, it also had social and cultural meaning as an object, a curio or secular relic. This paper considers the appeal of notorious bodies. From books bound in the skin of a criminal, to preserved and exhibited heads, from fragments of the hangman’s rope to the exhibition of the skeleton, the story of the afterlife of criminal bodies and the material culture most immediately associated with them begins with the collection and exchange of bodies and moves into contemporary preoccupations with authenticity. This paper considers the bodies of three notorious criminals of the eighteenth century: Eugene Aram, William Burke and William Corder. It ends with some reflections on the glamour of the authentic body of a notorious or celebrated individual – using the response to the discovery of the body of Richard III as an example. PMID:27366110

  15. In vitro inhibitory effects of palonosetron hydrochloride, bevacizumab and cyclophosphamide on purified paraoxonase-I (hPON1) from human serum.

    PubMed

    Türkeş, Cüneyt; Söyüt, Hakan; Beydemir, Şükrü

    2016-03-01

    In this study, we investigated the effects of the drugs, palonosetron hydrochloride, bevacizumab and cyclophosphamide, on human serum paraoxonase-I (hPON1) enzyme activity in in vitro conditions. The enzyme was purified ∼231-fold with 34.2% yield by using ammonium sulphate precipitation, DEAE-Sephadex A-50 ion-exchange chromatography and Sephadex G-200 gel-filtration chromatography from human serum. hPON1 exhibited a single protein band on the SDS polyacrylamide gel electrophoresis. The inhibition studies were performed on paraoxonase activity of palonosetron hydrochloride, bevacizumab and cyclophosphamide. Ki constants were found as 0.033±0.001, 0.054±0.003mM and 3.419±0.518mM, respectively. Compared to the inhibition rates of the drugs, palonosetron hydrochloride has the maximum inhibition rate. However, inhibition mechanisms of the drugs were determined as noncompetitive by Lineweaver-Burk curves. PMID:26915059

  16. Essential oil yield and chemical composition changes during leaf ontogeny of palmarosa (Cymbopogon martinii var. motia).

    PubMed

    Rao, Bhaskaruni R Rajeswara; Rajput, Dharmendra K; Patel, Rajendra P; Purnanand, Somasi

    2010-12-01

    Changes in leaf biomass yield, essential oil yield, and chemical composition were investigated during leaf ontogeny of palmarosa {Cymbopogon martinii (Roxb.) Wats. var. motia Burk., family Poaceae}. Eleven leaves representing different developmental stages, serially numbered from the apex to the base of the plant were utilized for the study. Leaf biomass yield increased up to the eighth leaf. Essential oil recovery increased up to the third leaf; thereafter it decreased. Minimum essential oil recovery was observed in the eleventh leaf. Essential oil yield/leaf increased up to the sixth leaf. Essential oil yield and concentrations of linalool, alpha-terpineol, geranyl isobutyrate and geraniol were relatively higher in the essential oils of mature, older leaves. Essential oil recovery, and percentages of myrcene, beta-caryophyllene, geranyl acetate, (E,Z) farnesol and geranyl hexanoate were higher in the essential oils of young, expanding leaves. PMID:21299128

  17. Hybrid density functional study of electronic and optical properties of phase change memory material: Ge2Sb2Te5

    NASA Astrophysics Data System (ADS)

    Kaewmaraya, T.; Ramzan, M.; Löfâs, H.; Ahuja, Rajeev

    2013-01-01

    In this article, we use hybrid density functional (HSE06) to study the crystal and electronic structures and optical properties of well known phase change memory material Ge2Sb2Te5. We calculate the structural parameters, band gaps, and dielectric functions of three stable structures of this material. We also analyze the electron charge distribution using the Bader's theory of charge analysis. We find that hybrid density functional slightly overestimates the value of "c" parameter. However, overall, our results calculated with the use of hybrid density functional (HSE06) are very close to available experimental values than calculated with the use of Perdew Burke-Ernzerhof functional. Specifically, the electronic band gap values of this material calculated with HSE06 are in good agreement with the available experimental data in the literature. Furthermore, we perform the charge analysis and find that naive ionic model fails to explain the charge distribution between the constituent atoms, showing the complex nature of this compound.

  18. Diagnostic Categories in Autobiographical Accounts of Illness.

    PubMed

    Kelly, Michael P

    2015-01-01

    Working within frameworks drawn from the writings of Immanuel Kant, Alfred Schutz, and Kenneth Burke, this article examines the role that diagnostic categories play in autobiographical accounts of illness, with a special focus on chronic disease. Four lay diagnostic categories, each with different connections to formal medical diagnostic categories, serve as typifications to make sense of the way the lifeworld changes over the course of chronic illness. These diagnostic categories are used in conjunction with another set of typifications: lay epidemiologies, lay etiologies, lay prognostics, and lay therapeutics. Together these serve to construct and reconstruct the self at the center of the lifeworld. Embedded within the lay diagnostic categories are narratives of progression, regression, or stability, forms of typification derived from literary and storytelling genres. These narratives are developed by the self in autobiographical accounts of illness. PMID:26657684

  19. Atomistic Explanation of Shear-Induced Amorphous Band Formation in Boron Carbide

    NASA Astrophysics Data System (ADS)

    An, Qi; Goddard, William A.; Cheng, Tao

    2014-08-01

    Boron carbide (B4C) is very hard, but its applications are hindered by stress-induced amorphous band formation. To explain this behavior, we used density function theory (Perdew-Burke-Ernzerhof flavor) to examine the response to shear along 11 plausible slip systems. We found that the (011¯ 1¯)/⟨1¯101⟩ slip system has the lowest shear strength (consistent with previous experimental studies) and that this slip leads to a unique plastic deformation before failure in which a boron-carbon bond between neighboring icosahedral clusters breaks to form a carbon lone pair (Lewis base) on the C within the icosahedron. Further shear then leads this Lewis base C to form a new bond with the Lewis acidic B in the middle of a CBC chain. This then initiates destruction of this icosahedron. The result is the amorphous structure observed experimentally. We suggest how this insight could be used to strengthen B4C.

  20. Atomistic explanation of shear-induced amorphous band formation in boron carbide.

    PubMed

    An, Qi; Goddard, William A; Cheng, Tao

    2014-08-29

    Boron carbide (B4C) is very hard, but its applications are hindered by stress-induced amorphous band formation. To explain this behavior, we used density function theory (Perdew-Burke-Ernzerhof flavor) to examine the response to shear along 11 plausible slip systems. We found that the (0111)/<1101> slip system has the lowest shear strength (consistent with previous experimental studies) and that this slip leads to a unique plastic deformation before failure in which a boron-carbon bond between neighboring icosahedral clusters breaks to form a carbon lone pair (Lewis base) on the C within the icosahedron. Further shear then leads this Lewis base C to form a new bond with the Lewis acidic B in the middle of a CBC chain. This then initiates destruction of this icosahedron. The result is the amorphous structure observed experimentally. We suggest how this insight could be used to strengthen B4C. PMID:25215991

  1. Analysis of the electronic structure of ZrO{sub 2} by Compton spectroscopy

    SciTech Connect

    Mahammad, F. M.; Mahammed, S. F.; Kumar, R.; Vijay, Y. K.; Sharma, B. K.; Sharma, G.

    2013-07-15

    The electronic structure of ZrO{sub 2} is studied using the Compton scattering technique. The first-ever Compton profile measurement on polycrystalline ZrO{sub 2} was obtained using 59.54 keV gamma-rays emanating from the {sup 241}Am radioisotope. To explain the experimental data, we compute theoretical Compton profile values using the method of linear combination of atomic orbitals in the framework of density functional theory. The correlation scheme proposed by Perdew-Burke-Ernzerhof and the exchange scheme of Becke are considered. The ionic-model-based calculations for a number of configurations, i.e., Zr{sup +x}(O{sup -x/2}){sub 2} (0 {<=} x {<=} 2), are also performed to estimate the charge transfer on compound formation, and the study supports transfer of 1.5 electrons from Zr to O atoms.

  2. Benchmarking exchange-correlation functionals for hydrogen at high pressures using quantum Monte Carlo

    SciTech Connect

    Clay, Raymond C.; Mcminis, Jeremy; McMahon, Jeffrey M.; Pierleoni, Carlo; Ceperley, David M.; Morales, Miguel A.

    2014-05-01

    The ab initio phase diagram of dense hydrogen is very sensitive to errors in the treatment of electronic correlation. Recently, it has been shown that the choice of the density functional has a large effect on the predicted location of both the liquid-liquid phase transition and the solid insulator-to-metal transition in dense hydrogen. To identify the most accurate functional for dense hydrogen applications, we systematically benchmark some of the most commonly used functionals using quantum Monte Carlo. By considering several measures of functional accuracy, we conclude that the van der Waals and hybrid functionals significantly outperform local density approximation and Perdew-Burke-Ernzerhof. We support these conclusions by analyzing the impact of functional choice on structural optimization in the molecular solid, and on the location of the liquid-liquid phase transition.

  3. Spectroscopic analyses and studies on respective interaction of cyanuric acid and uric acid with bovine serum albumin and melamine

    NASA Astrophysics Data System (ADS)

    Chen, Dandan; Wu, Qiong; Wang, Jun; Wang, Qi; Qiao, Heng

    2015-01-01

    In this work, the fluorescence quenching was used to study the interaction of cyanuric acid (CYA) and uric acid (UA) with bovine serum albumin (BSA) at two different temperatures (283 K and 310 K). The bimolecular quenching constant (Kq), apparent quenching constant (Ksv), effective binding constant (KA) and corresponding dissociation constant (KD), binding site number (n) and binding distance (r) were calculated by adopting Stern-Volmer, Lineweaver-Burk, Double logarithm and overlap integral equations. The results show that CYA and UA are both able to obviously bind to BSA, but the binding strength order is BSA + CYA < BSA + UA. And then, the interactions of CYA and UA with melamine (MEL) under the same conditions were also studied by using similar methods. The results indicates that both CYA and UA can bind together closely with melamine (MEL). It is wished that these research results would facilitate the understanding the formation of kidney stones and gout in the body after ingesting excess MEL.

  4. Polymorphism of resorcinol explored by complementary vibrational spectroscopy (FT-RS, THz-TDS, INS) and first-principles solid-state computations (plane-wave DFT).

    PubMed

    Drużbicki, Kacper; Mikuli, Edward; Pałka, Norbert; Zalewski, Sławomir; Ossowska-Chruściel, Mirosława D

    2015-01-29

    The polymorphism of resorcinol has been complementary studied by combining Raman, time-domain terahertz, and inelastic neutron scattering spectroscopy with modern solid-state density functional theory (DFT) calculations. The spectral differences, emerging from the temperature-induced structural phase transition, have been successfully interpreted with an emphasis on the low-wavenumber range. The given interpretation is based on the plane-wave DFT computations, providing an excellent overall reproduction of both wavenumbers and intensities and revealing the source of the observed spectral differences. The performance of the generalized gradient approximation (GGA) functionals in prediction of the structural parameters and the vibrational spectra of the normal-pressure polymorphs of resorcinol has been extensively examined. The results show that the standard Perdew, Burke, and Ernzerhof (PBE) approach along with its "hard" revised form tends to be superior if compared to the "soft" GGA approximation. PMID:25564699

  5. Deformation of Eemian and Glacial ice at NEEM, Greenland

    NASA Astrophysics Data System (ADS)

    Keegan, Kaitlin; Dahl-Jensen, Dorthe; Montagnat, Maurine; Weikusat, Ilka; Kipfstuhl, Sepp

    2015-04-01

    New findings from deep Greenland ice cores and airborne radio echo sounding (RES) images show that basal ice flow is very unstable, and a basal layer of disturbed ice is often observed. At NEEM, Greenland this folding occurs at the boundary between the Eemian and glacial ice regimes, suggesting that differences in physical properties of the ice play a role in the disturbance. Past work in metallurgy (Burke, 1957) and ice (Hammer et al., 1978; Langway et al., 1988; Dahl-Jensen et al., 1997), suggests that impurity content controls grain evolution, and therefore deformation, which we hypothesize to be analogous to the differences in ice flow seen deep in the NEEM ice core. Here we present results of fabric, grain size, impurity content, and deformation studies from samples above and below this unstable boundary in the ice sheet.

  6. Effects of non-unity Lewis numbers in diffusion flames

    NASA Technical Reports Server (NTRS)

    Linan, A.; Orlandi, P.; Verzicco, R.; Higuera, F. J.

    1994-01-01

    The purpose of this work is to carry out direct numerical simulations of diffusion controlled combustion with non-unity Lewis numbers for the reactants and products, thus accounting for the differential diffusion effects of the temperature and concentration fields. We use a formulation based on combining the conservation equations in a way to eliminate the reaction terms similar to the method used by Burke and Schumann (1928) for unity Lewis numbers. We present calculations for an axisymmetric fuel jet and for a planar, time evolving mixing layer, leaving out the effects of thermal expansion and variations of the transport coefficients due to the heat release. Our results show that the front of the flame shifts toward the fuel or oxygen sides owing to the effect of the differential diffusion and that the location of maximum temperature may not coincide with the flame. The dependence of the distribution of the reaction products on their Lewis number has been investigated.

  7. Statistical theory and methodology for remote sensing data analysis

    NASA Technical Reports Server (NTRS)

    Odell, P. L.

    1974-01-01

    A model is developed for the evaluation of acreages (proportions) of different crop-types over a geographical area using a classification approach and methods for estimating the crop acreages are given. In estimating the acreages of a specific croptype such as wheat, it is suggested to treat the problem as a two-crop problem: wheat vs. nonwheat, since this simplifies the estimation problem considerably. The error analysis and the sample size problem is investigated for the two-crop approach. Certain numerical results for sample sizes are given for a JSC-ERTS-1 data example on wheat identification performance in Hill County, Montana and Burke County, North Dakota. Lastly, for a large area crop acreages inventory a sampling scheme is suggested for acquiring sample data and the problem of crop acreage estimation and the error analysis is discussed.

  8. Purification and characterization of organic solvent stable serine alkaline protease from newly isolated Bacillus circulans M34.

    PubMed

    Sari, Esma; Loğoğlu, Elif; Öktemer, Atilla

    2015-09-01

    A protease from newly isolated Bacillus circulans M34 was purified by Q-Sepharose anion exchange chromatography and Sepharose-bacitracin affinity chromatography followed by (NH4)2SO4 precipitation. The molecular mass of the purified enzyme was determined using SDS-PAGE. The optimum pH and temperature for protease activity were 11 and 50°C, respectively. The effect of various metal ions on protease activity was investigated. Alkaline protease from Bacillus circulans M34 wase activated by Zn(2+), Cu(2+) and Co(2+) up to 31%. The purified protease was found to be stable in the organic solvents, surfactants and oxidizing agent. The substrate specificity of purified protease was investigated towards different substrates. The protease was almost completely inhibited by the serine protease inhibitor phenylmethanesulfonyl fluoride. The kinetic parameters of the purified protease, maximum rate (Vmax) and Michaelis constant (Km), were determined using a Lineweaver-Burk plot. PMID:25677873

  9. Pressure dependence of electronic properties of BaI{sub 2}

    SciTech Connect

    Kumar, Pradeep; Vedeshwar, Agnikumar G.

    2015-08-28

    We present Density Functional Theoretical (DFT) calculations of the electronic properties of scintillator material BaI{sub 2} under pressure which were carried out using Perdew-Burke-Ernzerhof genralized gradient approximation. We found that BaI{sub 2} is a direct band gap material with band gap calculated as 3.35 eV. The pressure effect on BaI{sub 2} indicates a linear monotonously decreasing band gap and increasing valence band width with pressure. We have observed the shifting of band extrema from the Γ point with pressure. The pressure coefficient of band gap is found to be −0.047 eV/GPa. The interatomic ionicity factor of BaI{sub 2} is found to be 0.51. Trends in bonding and ionicity under pressure are also discussed.

  10. Reconstructing African topography over the past 30 Myrs with high-resolution tomography-based convection modelling

    NASA Astrophysics Data System (ADS)

    Moucha, R.; Forte, A. M.; Rowley, D. B.; Braun, J.; Mitrovica, J. X.; Simmons, N. A.; Grand, S. P.

    2009-12-01

    Geologists (e.g. Krenkel 1922; Holmes 1944; Burke 1996) have long recognized the unique 'basin and swell' structure of the African continent and adjoining ocean basins. This topography is unique on our planet and is characterized by large-scale extensional features such as the East African Rift, recent widespread magmatic activity, and epeirogeny. These enigmatic surface features have long suggested that the African continent is shaped by significant dynamic forcing originating in the underlying mantle. Utilizing present-day heterogeneity derived from a high-resolution joint seismic-geodynamic tomography model (Simmons et al., 2009), we reconstruct the late Cenozoic dynamic topography of Africa by carrying out backward-in-time mantle flow simulations. In this presentation we will explore the geological implications, and associated uncertainties, of our predictions of the temporal evolution of African topography, with a particular focus on the most dynamic surface features such as the East African Rift system and adjacent basins.

  11. Milestones toward Majorana-based quantum computing

    NASA Astrophysics Data System (ADS)

    Alicea, Jason

    Experiments on nanowire-based Majorana platforms now appear poised to move beyond the preliminary problem of zero-mode detection and towards loftier goals of realizing non-Abelian statistics and quantum information applications. Using an approach that synthesizes recent materials growth breakthroughs with tools long successfully deployed in quantum-dot research, I will outline a number of relatively modest milestones that progressively bridge the gap between the current state of the art and these grand longer-term challenges. The intermediate Majorana experiments surveyed in this talk should be broadly adaptable to other approaches as well. Supported by the National Science Foundation (DMR-1341822), Institute for Quantum Information and Matter, and Walter Burke Institute at Caltech.

  12. First-principles study of structural, electronic, elastic and phonon properties of AB2O4(A = Ge,Si;B = Mg,Zn,Cd) spinel oxides

    NASA Astrophysics Data System (ADS)

    Candan, Abdullah; Uǧur, Gökay

    2016-01-01

    The structural, electronic, elastic and phonon properties of the cubic spinels AB2O4 (A = Ge, Si; B = Mg, Zn, Cd) compounds at zero pressure are investigated via density functional theory (DFT) using the Perdew-Burke-Ernzerhof (PBE) exchange-correlation functional. It has been shown that the predicted values of the structural parameters (a0 and u), bulk modulus (B), elastic constants (Cij), shear modulus G and B/G ratio are in good agreement with the previously reported results. The phonon dispersion curves of the AB2O4 (A = Ge, Si; B = Mg, Zn, Cd) are calculated for the first time using the direct method. The estimated phonon spectra indicate that GeMg2O4, GeZn2O4, GeCd2O4, SiMg2O4 and SiZn2O4 are dynamically stable in the cubic spinel structure.

  13. Sensitive Training Through Body Awareness to Improve the Writing of Patients with Writer’s Cramp

    PubMed Central

    Waissman, Flavia Quadros Boisson; Orsini, Marco; Nascimento, Osvaldo J.M.; Leite, Marco Antônio A.; Pereira, João Santos

    2013-01-01

    The aim of this article is to evaluate if body awareness is important to improve the writing ability before using the splints. Twelve patients with writer’s cramp were evaluated by a specialist in movement disorders. The Burke-Fahn-Marsden Scale (BFM), the Jedynak Protocol and the Analog Pain Scale were used. The rehabilitation training was administered over an eight-week period, in two phases of four weeks each, twice a week. Each session would last 60 minutes. A significant improvement was shown, not only in the motor, but also in the pain perception, through the BFM scale, the Jedynak Protocol and the Analog Pain Scale. Therefore, we conclude that the motor training, thanks to the body awareness and immobilization by splints of the affected dystonic musculature, led to an important improvement in the writer’s cramp writing. PMID:24416488

  14. Reproducibility in density functional theory calculations of solids.

    PubMed

    Lejaeghere, Kurt; Bihlmayer, Gustav; Björkman, Torbjörn; Blaha, Peter; Blügel, Stefan; Blum, Volker; Caliste, Damien; Castelli, Ivano E; Clark, Stewart J; Dal Corso, Andrea; de Gironcoli, Stefano; Deutsch, Thierry; Dewhurst, John Kay; Di Marco, Igor; Draxl, Claudia; Dułak, Marcin; Eriksson, Olle; Flores-Livas, José A; Garrity, Kevin F; Genovese, Luigi; Giannozzi, Paolo; Giantomassi, Matteo; Goedecker, Stefan; Gonze, Xavier; Grånäs, Oscar; Gross, E K U; Gulans, Andris; Gygi, François; Hamann, D R; Hasnip, Phil J; Holzwarth, N A W; Iuşan, Diana; Jochym, Dominik B; Jollet, François; Jones, Daniel; Kresse, Georg; Koepernik, Klaus; Küçükbenli, Emine; Kvashnin, Yaroslav O; Locht, Inka L M; Lubeck, Sven; Marsman, Martijn; Marzari, Nicola; Nitzsche, Ulrike; Nordström, Lars; Ozaki, Taisuke; Paulatto, Lorenzo; Pickard, Chris J; Poelmans, Ward; Probert, Matt I J; Refson, Keith; Richter, Manuel; Rignanese, Gian-Marco; Saha, Santanu; Scheffler, Matthias; Schlipf, Martin; Schwarz, Karlheinz; Sharma, Sangeeta; Tavazza, Francesca; Thunström, Patrik; Tkatchenko, Alexandre; Torrent, Marc; Vanderbilt, David; van Setten, Michiel J; Van Speybroeck, Veronique; Wills, John M; Yates, Jonathan R; Zhang, Guo-Xu; Cottenier, Stefaan

    2016-03-25

    The widespread popularity of density functional theory has given rise to an extensive range of dedicated codes for predicting molecular and crystalline properties. However, each code implements the formalism in a different way, raising questions about the reproducibility of such predictions. We report the results of a community-wide effort that compared 15 solid-state codes, using 40 different potentials or basis set types, to assess the quality of the Perdew-Burke-Ernzerhof equations of state for 71 elemental crystals. We conclude that predictions from recent codes and pseudopotentials agree very well, with pairwise differences that are comparable to those between different high-precision experiments. Older methods, however, have less precise agreement. Our benchmark provides a framework for users and developers to document the precision of new applications and methodological improvements. PMID:27013736

  15. FP-LAPW investigations of SrS1-xSex, SrS1-xTex and SrSe1-xTex ternary alloys

    NASA Astrophysics Data System (ADS)

    Labidi, S.; Meradji, H.; Ghemid, S.; Labidi, M.; El Haj Hassan, F.

    2008-11-01

    The ab initio full potential linearized augmented plane wave (FP-LAPW) method within density functional theory (DFT) was applied to study the effect of composition on the structural, electronic, optical and thermodynamic properties of SrS1-xSex, SrS1-xTex and SrSe1-xTex ternary alloys. For exchange-correlation energy and corresponding potential, the generalized gradient approximation (GGA) by Perdew-Burke-Ernzerhof (PBE) and Engel-Vosko (EVGGA) have been used. Deviation of the lattice constants from Vegard's law and the bulk modulus from linear concentration dependence (LCD) were observed for the three alloys. The microscopic origins of the gap bowing were explained by using the approach of Zunger and co-workers. The refractive index and optical dielectric constant for the alloys of interest are calculated by using different models. In addition the thermodynamic stability of the alloys was investigated by calculating the critical temperatures of alloys.

  16. Vaccinations in disease models with antibody-dependent enhancement.

    PubMed

    Billings, Lora; Fiorillo, Amy; Schwartz, Ira B

    2008-02-01

    This paper examines the effects of single-strain vaccine campaigns on the dynamics of an epidemic multistrain model with antibody-dependent enhancement (ADE). ADE is a disease spreading process causing individuals with their secondary infection to be more infectious than during their first infection by a different strain. We follow the two-strain ADE model described in Cummings et al. [D.A.T. Cummings, Doctoral Thesis, Johns Hopkins University, 2004] and Schwartz et al. [I.B. Schwartz, L.B. Shaw, D.A.T. Cummings, L. Billings, M. McCrary, D. Burke, Chaotic desynchronization of multi-strain diseases, Phys. Rev. E, 72:art. no. 066201, 2005]. After describing the model and its steady state solutions, we modify it to include vaccine campaigns and explore if there exists vaccination rates that can eradicate one or more strains of a virus with ADE. PMID:17923138

  17. Brain distribution pharmacokinetics and integrated pharmacokinetics of Panax Notoginsenoside R1, Ginsenosides Rg1, Rb1, Re and Rd in rats after intranasal administration of Panax Notoginseng Saponins assessed by UPLC/MS/MS.

    PubMed

    Guo, Qingli; Li, Pengyue; Wang, Zhen; Cheng, Yanke; Wu, Huichao; Yang, Bing; Du, Shouying; Lu, Yang

    2014-10-15

    Panax notoginseng saponins (PNS) constitute the main active components of a traditional Chinese medicine, Panax notoginseng (Burk.) F.H. Chen (Sanqi). To investigate brain distribution of Panax Notoginsenoside R1, Ginsenosides Rg1, Rb1, Re, and Rd, and the integrated PNS in rats, their contents in cortex, striatum, hypothalamus, medulla oblongata, hippocampus and olfactory bulb were simultaneously measured by UPLC-MS/MS. Sample preparation was carried out by the protein precipitation technique with an internal Digoxin standard. The method described here was highly efficient, with short run time, excellent specificity and sensitivity, and successfully applied for pharmacokinetics studies. NGR1, GRg1, GRb1, GRe and GRd from PNS have been detected in all six brain regions studied and quantified accurately. These findings provide more insight for further understanding of the main ways from the nasal cavity to brain as well as the migration of nasally applied drugs into the CNS parenchyma. PMID:25203723

  18. High energy Compton spectroscopy and electronic structure of Laves phase ZrFe2

    NASA Astrophysics Data System (ADS)

    Bhatt, Samir; Kumar, Kishor; Arora, Gunjan; Bapna, Komal; Ahuja, B. L.

    2016-08-01

    We present the first-ever experimental Compton profile of Laves phase ZrFe2 using indigenous 20 Ci 137Cs Compton spectrometer. To annotate the experimental electron momentum density, we have calculated the theoretical Compton profiles using density functional theory (DFT) and hybridization of Hartree-Fock and DFT within linear combination of atomic orbitals (LCAO) method. The spin-polarized energy bands and density of states are computed using LCAO and full potential-linearized augmented plane wave methods. The revised Perdew-Burke-Ernzerhof functional (for solids) based theoretical profile gives a marginally better agreement with the experimental profile as compared to other approximations considered in the present work. The Fermi surface topology of ZrFe2 is explained in terms of majority- and minority-spin energy bands.

  19. Temperature Diffusion Waves in Magnetized Plasmas

    NASA Astrophysics Data System (ADS)

    Reynolds, M. A.; Morales, G. J.; Maggs, J. E.

    2002-11-01

    Fluctuations of localized heat sources manifest themselves as temperature diffusion waves throughout the plasma surrounding the source, with anisotropic propagation characteristics due to the anisotropic nature of the thermal conductivity. In fact, fluctuations in electron temperature have been observed experimentally in studies of heat transport in magnetized temperature filaments (Burke et al., Phys. Plasmas, 7, 1397, 2000) where the anisotropic nature was of paramount interest. Here, the theory of temperature diffusion waves in a magnetized plasma is presented, and the properties of these waves are investigated both analytically and numerically. Results from the one-dimensional (parallel), linear theory of diffusion waves are used to shed light on the results obtained by a two-dimensional (parallel and perpendicular) transport code. Features that are investigated include the spatial structure of wave amplitude and phase, the effect that the size of the source region has on the spatial structure (i.e., radial localization), and the strongly nonlinear (large amplitude source fluctuations) limit.

  20. Assessment of a long-range corrected hybrid functional

    SciTech Connect

    Vydrov, Oleg A.; Scuseria, Gustavo E.

    2006-12-21

    Common approximate exchange-correlation functionals suffer from self-interaction error, and as a result, their corresponding potentials have incorrect asymptotic behavior. The exact asymptote can be imposed by introducing range separation into the exchange component and replacing the long-range portion of the approximate exchange by the Hartree-Fock counterpart. The authors show that this long-range correction works particularly well in combination with the short-range variant of the Perdew-Burke-Ernzerhof (PBE) exchange functional. This long-range-corrected hybrid, here denoted LC-{omega}PBE, is remarkably accurate for a broad range of molecular properties, such as thermochemistry, barrier heights of chemical reactions, bond lengths, and most notably, description of processes involving long-range charge transfer.

  1. [Structure and biological action on cardiovascular systems of saponins from Panax notoginseng].

    PubMed

    Li, Juan; Wang, Ru-feng; Yang, Li; Wang, Zheng-tao

    2015-09-01

    Notoginseng Radix et Rhizoma (Sanqi), the underground part of Panax notoginseng (Burk.) F. H. Chen (Araliaceae) is commonly used in Chinese medicine for treatment of haemorrhage, haemostasis, swelling, etc. The aerial part including leaves, flowers and fruits are also applied for similar functions. Triterpenoid saponins are considered to be responsible for the biological activities of Sanqi. Up to date, more than 100 saponins have been isolated from theroots, rhizomes, leaves, flowers and fruits of P. notoginseng. The reported saponins can be classified into protopanaxadiol (PPD), protopanaxatriol (PPT), C17 side-chain varied and other types, according to the skeletons of the aglycons. The present review summarizes the saponins isolated from P. notoginseng and their distribution in different medicinal organs, as well as the pharmacological actions on cardiovascular system. PMID:26978992

  2. Fast Radio Bursts: The Search for Their Origins

    NASA Astrophysics Data System (ADS)

    Burke Spolaor, Sarah

    2015-08-01

    Fast Radio Bursts (FRBs) are millisecond-duration radio signals whose swept-frequency signals indicate a non-local origin.FRB science has been building rapidly since the first discovery of an FRB in 2007; proof of an FRB population in 2013 (Thornton et al.) was quickly followed by further evidence of their likely, although not yet definite, extragalactic origin (e.g. Kulkarni et al. 2014, Burke-Spolaor & Bannister 2014). Until recently, only circumstantial evidence allowed statements on what progenitors FRBs might arise from, and whether they are local, Galactic, or extragalactic. However, we are now able to detect FRB events in real-time, and have the capability to detect FRBs with radio interferometers. This has opened up the possibility to understand their origins through arcsecond localization and the identification of multi-wavelength counterparts. I will describe what we currently know about FRBs, and the status of the FRB hunt for their enigmatic origins.

  3. DFT investigations of structural and electronic properties of gallium arsenide (GaAs)

    NASA Astrophysics Data System (ADS)

    Anua, N. Najwa; Ahmed, R.; Saeed, M. A.; Shaari, A.; Haq, Bakhtiar Ul

    2012-09-01

    First principles calculations for structural and electronic properties of GaAs have been reported using a full potential linearized augmented plane wave (FP-LAPW) scheme of calculations developed within density functional theory (DFT). We use in this study local density approximation (LDA), Perdew-Burke-Ernzerhof parameterized generalized gradient approximation (PBE-GGA), Wu-Cohen parameterized GGA (WC-GGA) executed in WIEN2k code. In addition, to calculate band structure with high accuracy we used modified Becke-Johnson exchange potential (MBJ) + LDA approach. Our calculated lattice constant with GGA-WC is in good agreement to experimental value than LDA and PBE-GGA. Whereas our calculations for the band structure show that MBJ+ LDA approach gives much better results for band gap value as compared to other exchange correlation approaches.

  4. Purification of glucose-6-phosphate dehydrogenase and glutathione reductase enzymes from the gill tissue of Lake Van fish and analyzing the effects of some chalcone derivatives on enzyme activities.

    PubMed

    Kuzu, Muslum; Aslan, Abdulselam; Ahmed, Ishtiaq; Comakli, Veysel; Demirdag, Ramazan; Uzun, Naim

    2016-04-01

    Glucose-6-phosphate dehydrogenase (G6PD) and glutathione reductase (GR) are metabolically quite important enzymes. Within this study, these two enzymes were purified for the first time from the gills of Lake Van fish. In the purifying process, ammonium sulfate precipitation and 2',5'-ADP Sepharose 4B affinity column chromatography techniques for glucose-6-phosphate dehydrogenase, temperature degradation and 2',5'-ADP Sepharose 4B affinity column chromatography for glutathione reductase enzyme were used. The control of the enzyme purity and determination of molecular weight were done with sodium dodecyl sulfate polyacrylamide gel electrophoresis. K M and V max values were determined with Lineweaver-Burk plot. Besides, the effects of some chalcone derivatives on the purified enzymes were analyzed. For the ones showing inhibition effect, % activity-[I] figures were drawn and IC50 values were determined. K i value was calculated by using Cheng-Prusoff equation. PMID:26676512

  5. Study of phase transition and cohesive energy in MgO

    NASA Astrophysics Data System (ADS)

    Munjal, N.; Bhambhani, P.; Sharma, G.; Vyas, V.; Sharma, B. K.

    2012-07-01

    In this paper, we present first-principles study of phase transition and cohesive energy of MgO. The calculations are performed on the basis of density functional theory (DFT) based on linear combination of atomic orbitals (LCAO) method. In the present calculations, the generalized gradient approximation (GGA) proposed by Perdew-Burke- Ernzerhof (PBE) and Becke's scheme are considered to treat the correlation and exchange effects respectively. The study reveals that the stable phase of MgO is B1. The study also suggests B1 to B2 phase transition at 260.75 GPa and 10.98 eV cohesive energy of MgO in the stable phase. The calculated data are found in good agreement with the previous theoretical and experimental investigations.

  6. Electronic structure study of TiB2 and Ti2B

    NASA Astrophysics Data System (ADS)

    Vashistha, M.; Kabra, K.; Vyas, V.; Sharma, G.

    2015-06-01

    In this paper, the electronic properties of TiB2 and Ti2B are computed within the framework of Density Functional Theory (DFT) based on Linear Combination of Atomic Orbitals (LCAO) method. In the present calculations, the generalized gradient approximation (GGA) proposed by Perdew-Burke-Erenzerhof (PBE) and Becke's scheme are considered to treat the correlation and exchange effects respectively. TiB2 crystallizes in the hexagonal AlB2 type structure which is designated as C32 with the space group P6/mmm. While the crystal structure of Ti2B described in this paper is isomorphous to the body centered tetragonal (Al2Cu - type) structure with space group I4/mcm.

  7. Methamphetamine and the changing face of child welfare: practice principles for child welfare workers.

    PubMed

    Connell-Carrick, Kelli

    2007-01-01

    Methamphetamine use and production is changing child welfare practice. Methamphetamine is a significant public health threat (National Institute of Justice, 1999) reaching epidemic proportions (Anglin, Burke, Perrochet, Stamper, & Dawud-Nouris, 2000). The manufacturing of methamphetamine is a serious problem for the child welfare system, yet child welfare has not addressed the needs of children living in homes where methamphetamine is manufactured (U.S. Department of Justice, 2002; DOJ, 2003; Altshuler, 2005). This article presents key issues for child welfare workers related to the use, production, and effects of methamphetamine on children and families, and identifies practice principles for child welfare workers in order to ensure safety for victims, parents, and workers themselves. PMID:17722684

  8. Reproductive failure of dominant males in the poeciliid fish Limia perugiae determined by DNA fingerprinting.

    PubMed

    Schartl, M; Erbelding-Denk, C; Hölter, S; Nanda, I; Schmid, M; Schröder, J H; Epplen, J T

    1993-08-01

    Hierarchical structures among male individuals in a population are frequently reflected in differences in aggressive and reproductive behavior and access to the females. In general, social dominance requires large investments, which in turn then may have to be compensated for by high reproductive success. However, this hypothesis has so far only been sufficiently tested in small mating groups (one or two males with one or two females) due to the difficulties of determining paternity by conventional methods. DNA fingerprinting overcomes these problems by offering the possibility to determine genetic relationships and mating patterns within larger groups [Burke, T. (1989) Trends Ecol. Evol. 4, 139-144]. We show here that in the poeciliid fish Limia perugiae, in small mating groups the dominant male has a mating success of 100%, whereas in larger groups its contribution to the offspring unexpectedly drops to zero. PMID:8346218

  9. Systems Engineering Management Plan NASA Traffic Aware Planner Integration Into P-180 Airborne Test-Bed

    NASA Technical Reports Server (NTRS)

    Maris, John

    2015-01-01

    NASA's Traffic Aware Planner (TAP) is a cockpit decision support tool that provides aircrew with vertical and lateral flight-path optimizations with the intent of achieving significant fuel and time savings, while automatically avoiding traffic, weather, and restricted airspace conflicts. A key step towards the maturation and deployment of TAP concerned its operational evaluation in a representative flight environment. This Systems Engineering Management Plan (SEMP) addresses the test-vehicle design, systems integration, and flight-test planning for the first TAP operational flight evaluations, which were successfully completed in November 2013. The trial outcomes are documented in the Traffic Aware Planner (TAP) flight evaluation paper presented at the 14th AIAA Aviation Technology, Integration, and Operations Conference, Atlanta, GA. (AIAA-2014-2166, Maris, J. M., Haynes, M. A., Wing, D. J., Burke, K. A., Henderson, J., & Woods, S. E., 2014).

  10. Purification and characterisation of a novel angiotensin-I converting enzyme (ACE)-inhibitory peptide derived from the enzymatic hydrolysate of Enteromorpha clathrata protein.

    PubMed

    Pan, Saikun; Wang, Shujun; Jing, Lingling; Yao, Dongrui

    2016-11-15

    Hydrolysates containing angiotensin-I converting enzyme (ACE)-inhibitory peptide were prepared from Enteromorpha clathrata protein using alcalase. The hydrolysates were fractionated into two molecular-weight ranges (below and above 10kDa) by ultrafiltration. The below-10kDa fraction showed higher ACE-inhibitory activity and was subsequently purified by Sephadex G-15 gel filtration chromatography. The structure of active peptide was identified as Pro-Ala-Phe-Gly by HPLC-Q-TOF-MS and its IC50 value was 35.9μM. The yield of this peptide from E. clathrata protein was 0.82%. Lineweaver-Burk plots demonstrated that the inhibitory kinetic mechanism of this peptide was non-competitive. Stability study revealed that the purified peptide showed resistance against gastrointestinal proteases. Thus, E. clathrata protein hydrolysate treated with alcalase is a beneficial ingredient of nutraceuticals and pharmaceuticals against hypertension and related diseases. PMID:27283651

  11. Renin inhibition activity by chitooligosaccharides.

    PubMed

    Park, Pyo-Jam; Ahn, Chang-Bum; Jeon, You-Jin; Je, Jae-Young

    2008-04-01

    Six kinds of chitooligosaccharides (COSs) with different molecular weight (MW) and degree of deacetylation (DD) were prepared using ultrafiltration membrane reactor, and their renin inhibition modes were evaluated. All the COSs showed the renin-inhibitory activities with dose-dependent manner, and 90-COSs had the potent renin-inhibitory activity than that of 50-COSs. Among them, 90-MMWCOS (1000-5000Da) exhibits the highest activity with IC(50) value of 0.51mg/mL and acts as competitive inhibitor with K(i) value of 0.28mg/mL by Lineweaver-Burk and Dixon plots. These results indicated that DD value and MW of COSs are important factors affecting renin-inhibitory activity. PMID:18313296

  12. New Directions in the Use of Virtual Reality for Food Shopping: Marketing and Education Perspectives

    PubMed Central

    Ruppert, Barb

    2011-01-01

    Virtual reality is used in marketing research to shape food selection and purchase decisions. Could it be used to counteract the marketing of less-nutritious foods and teach healthier food selection? This article presents interviews with Raymond Burke, Ph.D., of Indiana University Bloomington, and Rachel Jones, M.P.H., of the University of Utah College of Health. Topics covered include new marketing research technologies, including virtual reality simulations; retailing and shopper behavior; and the use of virtual grocery stores to help students explore quality of diet and food/nutrient relationships. The interviewees discuss how the technologies they have developed fit into research and behavior change related to obesity and diabetes. PMID:21527099

  13. Novel angiotensin I-converting enzyme inhibitory peptides derived from edible mushroom Agaricus bisporus (J.E. Lange) Imbach identified by LC-MS/MS.

    PubMed

    Lau, Ching Ching; Abdullah, Noorlidah; Shuib, Adawiyah Suriza; Aminudin, Norhaniza

    2014-04-01

    Angiotensin I-converting enzyme (ACE) inhibitors derived from foods are valuable auxiliaries to agents such as captopril. Eight highly functional ACE inhibitory peptides from the mushroom, Agaricus bisporus, were identified by LC-MS/MS. Among these peptides, the most potent ACE inhibitory activity was exhibited by AHEPVK, RIGLF and PSSNK with IC₅₀ values of 63, 116 and 129 μM, respectively. These peptides exhibited high ACE inhibitory activity after gastrointestinal digestion. Lineweaver-Burk plots suggested that AHEPVK and RIGLF act as competitive inhibitors against ACE, whereas PSSNK acts as a non-competitive inhibitor. Mushrooms can be a good component of dietary supplement due to their readily available source and, in addition, they rarely cause food allergy. Compared to ACE inhibitory peptides isolated from other edible mushrooms, AHEPVK, RIGLF and PSSNK have lower IC₅₀ values. Therefore, these peptides may serve as an ideal ingredient in the production of antihypertensive supplements. PMID:24262574

  14. Conidia immobilization of T-DNA inserted Trichoderma atroviride mutant AMT-28 with dichlorvos degradation ability and exploration of biodegradation mechanism.

    PubMed

    Sun, Wenliang; Chen, Yunpeng; Liu, Lixing; Tang, Jun; Chen, Jie; Liu, Peng

    2010-12-01

    An immobilizing conidia approach was used to study the degradation ability of dichlorvos in Trichoderma atroviride T-DNA insertional mutant AMT-28. Beads with 10(7) immobilized conidia per 100 mL of Na-alginate solution exhibited the highest degradation abilities. The immobilized conidia showed enhanced degradation abilities compared with immobilized or freely suspended mycelia. The immobilized cells kept good storage capacity and reusability. Dichlorvos was confirmed to be completely removed by mycelia of AMT-28 within 7 days using HPLC analysis. The dichlorvos degradation rates in auxotrophic Burk media varied and were significantly affected by nitrogen sources. There was no detectable biosorption and the removal of dichlorvos in AMT-28 was primarily attributed to a kind of Biomineralization process. PMID:20685111

  15. Nature of the band gap of halide perovskites ABX3 (A = CH3NH3, Cs; B = Sn, Pb; X = Cl, Br, I): First-principles calculations

    NASA Astrophysics Data System (ADS)

    Yuan, Ye; Xu, Run; Xu, Hai-Tao; Hong, Feng; Xu, Fei; Wang, Lin-Jun

    2015-11-01

    The electronic structures of cubic structure of ABX3(A=CH3NH3, Cs; B=Sn, Pb; X=Cl, Br, I) are analyzed by density functional theory using the Perdew-Burke-Ernzerhof exchange-correlation functional and using the Heyd-Scuseria-Ernzerhof hybrid functional. The valence band maximum (VBM) is found to be made up by an antibonding hybridization of B s and X p states, whereas bands made up by the π antibonding of B p and X p states dominates the conduction band minimum (CBM). The changes of VBM, CBM, and band gap with ion B and X are then systematically summarized. The natural band offsets of ABX3 are partly given. We also found for all the ABX3 perovskite materials in this study, the bandgap increases with an increasing lattice parameter. This phenomenon has good consistency with the experimental results. Project supported by the National Natural Science Foundation of China (Grant No. 11375112).

  16. INDEPENDENT CONFIRMATION AND REFINED PARAMETERS OF THE HOT JUPITER XO-5b

    SciTech Connect

    Pal, A.; Bakos, G. A.; Fernandez, J.; Sipocz, B.; Torres, G.; Latham, D. W.; Noyes, R. W.; Sasselov, D. D.; Esquerdo, G. A.; Stefanik, R. P.; Kovacs, Geza; Marcy, G. W.; Fischer, D. A.; Isaacson, H.; Butler, R. P.; Shporer, A.; Mazeh, T.

    2009-07-20

    We present HATNet observations of XO-5b, confirming its planetary nature based on evidence beyond that described in the announcement of Burke et al., namely, the lack of significant correlation between spectral bisector variations and orbital phase. In addition, using extensive spectroscopic measurements spanning multiple seasons, we investigate the relatively large scatter in the spectral line bisectors. We also examine possible blended stellar configurations (hierarchical triples, chance alignments) that can mimic the planet signals, and we are able to show that none are consistent with the sum of all the data. The analysis of the S activity index shows no significant stellar activity. Our results for the planet parameters are consistent with values in Burke et al., and we refine both the stellar and the planetary parameters using our data. XO-5b orbits a slightly evolved, late G type star with mass M{sub *} = 0.88 {+-} 0.03 M{sub sun}, radius R{sub *} = 1.08 {+-} 0.04 R{sub sun}, and metallicity close to solar. The planetary mass and radius are 1.059 {+-} 0.028 M {sub J} and 1.109 {+-} 0.050 R{sub J}, respectively, corresponding to a mean density of 0.96{sub -0.11}{sup +0.14} g cm{sup -3}. The ephemeris for the orbit is P = 4.187757 {+-} 0.000011 days, E = 2454552.67168 {+-} 0.00029 (BJD) with transit duration of 0.1307 {+-} 0.0013 days. By measuring four individual transit centers, we found no signs for transit timing variations. The planet XO-5b is notable for its anomalously high Safronov number and has a high surface gravity when compared to other transiting exoplanets with similar period.

  17. Penetration Electric Fields and Inner Magnetosphere Dynamics: A Model and Data Comparison

    NASA Technical Reports Server (NTRS)

    Maynard, Nelson C.

    1998-01-01

    Significant progress has been made on the analysis of the June, 1991 storm. We have completed the analysis of the CRRES and DMSP data sets. We have been able to follow the evolution during the storm of the inner edge of the electric field patterns in the dusk sector and its relation to electron boundaries, ion boundaries and the ring current. Whereas the CRRES data provide radial cuts out through the plasmasphere every I 0 hours, DMSP provides snapshots every orbit of the potential and particle boundaries. Electric field and energetic particle measurements from CRRES and ion drifts and energetic particle measurements from DMSP provide the principal data sets. The combined data set provides high resolution definition of the boundary motions over the phases of the storm. L shell differences between the DMSP and CRRES particle boundaries are easily explained by inflation of the dusk sector by the ring current. The electric field boundaries are typically associated with the ion boundary and the inner edge of the ring current except during rapid increases in the cross-polar cap potential. A significant fraction of the dusk cell potential is found inside the plasmasheet electron inner edge. Twice during the storm this potential exceeded 60 kV. A paper (copy attached) has been prepared (Burke et al., 1998) and submitted to JGR. An invited paper will be presented by Burke at the spring AGU meeting. An abstract has also been submitted to the COSPAR meeting for presentation by Maynard. New simulations have been carried out with the Rice Convection Model for the magnetic storm of June 4-5, 1991, and comparisons have been made with CRRES and DMSP data.

  18. Virulence characteristics of Aeromonas spp. in relation to source and biotype.

    PubMed Central

    Kirov, S M; Rees, B; Wellock, R C; Goldsmid, J M; Van Galen, A D

    1986-01-01

    The significance of Aeromonas spp. as potential water-borne enteric pathogens in Tasmania, Australia, an area with a mild climate and comparatively low year-round water temperatures, was investigated in view of the reported marked peak of Aeromonas-associated gastroenteritis in the summer and the apparent influence of temperature on levels of potentially pathogenic species in water supplies. Biochemical characteristics and virulence-associated properties--exotoxin production (hemolysin, enterotoxin), ability to grow at 43 degrees C, and possession of pili--were determined for 105 Tasmanian isolates of Aeromonas spp.; 43 isolates were from clinical specimens (greater than 75% diarrhea associated) and 62 were from water. Current classification schemes were evaluated for these isolates. A. sobria comprised 35% of the clinical isolates and 16% of the water isolates, A. hydrophila comprised 56 and 79%, and A. caviae comprised 9 and 5%. A total of 42% of the clinical isolates and 15% of the environmental isolates were enterotoxigenic (by the suckling mouse assay); these levels were significantly lower than those found in warmer environments. The majority (74%) of enterotoxigenic isolates were A. sobria. Enterotoxin-producing isolates possessed three or more of the following properties. They were Voges-Proskauer positive, did not hydrolyze arabinose, were positive for lysine decarboxylase, were able to grow at 43 degrees C, and produced large amounts of hemolysin (titer, greater than 128). Thus, the biochemical scheme proposed by Burke et al. (V. Burke, J. Robinson, H.M. Atkinson, and M. Gracey, J. Clin. Microbiol. 15:48-52, 1982) for identifying enterotoxigenic isolates appears to have widespread applicability. Environmental enterotoxigenic isolates possessed numerous pili, but these appeared to be lost once infection was established, as a similar isolates from patients with diarrhea were poorly piliated. Images PMID:2877008

  19. Modeling the thermosphere as a driven-dissipative thermodynamic system

    NASA Astrophysics Data System (ADS)

    Frey, W. R.; Lin, C. S.; Garvin, M. B.; Acebal, A. O.

    2014-03-01

    Thermospheric density impacts satellite position and lifetime through atmospheric drag. More accurate specification of thermospheric temperature, a key input to current models such as the High Accuracy Satellite Drag Model, can decrease model density errors. This paper improves the model of Burke et al. to model thermospheric temperatures using the magnetospheric convective electric field as a driver. In better alignment with Air Force satellite tracking operations, we model the arithmetic mean temperature, T1/2, defined by the Jacchia model as the mean of the daytime maximum and nighttime minimum exospheric temperatures occurring in opposite hemispheres at a given time, instead of the exospheric temperature used by Burke et al. Two methods of treating the solar ultraviolet (UV) contribution to T1/2 are tested. Two model parameters, the coupling and relaxation constants, are optimized for 38 storms from 2002 to 2008. Observed T1/2 values are derived from densities and heights measured by the Gravity Recovery and Climate Experiment satellite. The coupling and relaxation constants were found to vary over the solar cycle and are fit as functions of F10.7a, the 162 day average of the F10.7 index. Model results show that allowing temporal UV variation decreased model T1/2 errors for storms with decreasing UV over the storm period but increased T1/2 errors for storms with increasing UV. Model accuracy was found to be improved by separating storms by type (coronal mass ejection or co-rotating interaction region). The model parameter fits established will be useful for improving satellite drag forecasts.

  20. Modeling the Thermosphere As a Driven-Dissipative Thermodynamic System

    NASA Astrophysics Data System (ADS)

    Frey, W.; Lin, C. S.; Acebal, A. O.; Garvin, M. B.

    2014-12-01

    Thermospheric density impacts satellite position and lifetime through atmospheric drag. More accurate specification of thermospheric temperature, a key input to current models such as the High Accuracy Satellite Drag Model, can decrease model density errors. This paper improves the model of Burke et al. (2009) to model thermospheric temperatures using the magnetospheric convective electric field as a driver. In better alignment with Air Force satellite tracking operations, we model the arithmetic mean temperature, T1/2, defined by the Jacchia (1977) model as the mean of the daytime maximum and nighttime minimum exospheric temperatures occurring in opposite hemispheres at a given time, instead of the exospheric temperature used by Burke et al. (2009). Two methods of treating the solar ultraviolet (UV) contribution to T1/2 are tested. Two model parameters, the coupling and relaxation constants, are optimized for 38 storms from 2002 to 2008. Observed T1/2 values are derived from densities and heights measured by the Gravity Recovery and Climate Experiment satellite. The coupling and relaxation constants were found to vary over the solar cycle and are fit as functions of F10.7a, the 162 day average of the F10.7 index. Model results show that allowing temporal UV variation decreased model T1/2 errors for storms with decreasing UV over the storm period but increased T1/2errors for storms with increasing UV. Model accuracy was found to be improved by separating storms by type (coronal mass ejection or co-rotating interaction region). The model parameter fits established will be useful for improving satellite drag forecasts.

  1. Gyrokinetic theory and simulation of angular momentum transport

    SciTech Connect

    Waltz, R. E.; Staebler, G. M.; Candy, J.; Hinton, F. L.

    2007-12-15

    A gyrokinetic theory of turbulent toroidal angular momentum transport as well as modifications to neoclassical poloidal rotation from turbulence is formulated starting from the fundamental six-dimensional kinetic equation. The gyro-Bohm scaled transport is evaluated from toroidal delta-f gyrokinetic simulations using the GYRO code [Candy and Waltz, J. Comput. Phys. 186, 545 (2003)]. The simulations recover two pinch mechanisms in the radial transport of toroidal angular momentum: The slab geometry ExB shear pinch [Dominguez and Staebler, Phys. Fluids B 5, 387 (1993)] and the toroidal geometry 'Coriolis' pinch [Peeters, Angioni, and Strintzi, Phys. Rev. Lett. 98, 265003 (2007)]. The pinches allow the steady state null stress (or angular momentum transport flow) condition required to understand intrinsic (or spontaneous) toroidal rotation in heated tokamak without an internal source of torque [Staebler, Kinsey, and Waltz, Bull. Am. Phys. Soc. 46, 221 (2001)]. A predicted turbulent shift in the neoclassical poloidal rotation [Staebler, Phys. Plasmas 11, 1064 (2004)] appears to be small at the finite relative gyroradius (rho-star) of current experiments.

  2. Influence of the centrifugal force and parallel dynamics on the toroidal momentum transport due to small scale turbulence in a tokamak

    SciTech Connect

    Peeters, A. G.; Camenen, Y.; Casson, F. J.; Hornsby, W. A.; Snodin, A. P.; Strintzi, D.; Angioni, C.

    2009-04-15

    The paper derives the gyro-kinetic equation in the comoving frame of a toroidally rotating plasma, including both the Coriolis drift effect [A. G. Peeters et al., Phys. Rev. Lett. 98, 265003 (2007)] as well as the centrifugal force. The relation with the laboratory frame is discussed. A low field side gyro-fluid model is derived from the gyro-kinetic equation and applied to the description of parallel momentum transport. The model includes the effects of the Coriolis and centrifugal force as well as the parallel dynamics. The latter physics effect allows for a consistent description of both the Coriolis drift effect as well as the ExB shear effect [R. R. Dominguez and G. M. Staebler, Phys. Fluids B 5, 3876 (1993)] on the momentum transport. Strong plasma rotation as well as parallel dynamics reduce the Coriolis (inward) pinch of momentum and can lead to a sign reversal generating an outward pinch velocity. Also, the ExB shear effect is, in a similar manner, reduced by the parallel dynamics and stronger rotation.

  3. Cis-METHYL Vinyl Ether: the Rotational Spectrum up to 600 GHz

    NASA Astrophysics Data System (ADS)

    Kolesniková, Lucie; Daly, Adam M.; Alonso, José L.

    2014-06-01

    Astronomical observation of dimethyl ether, methyl ethyl ether places the methyl vinyl ether among the species of potential interstellar relevance. The millimeter and submillimeter-wave transitions pertaining to the vibrational ground state and the first excited states of the methoxy, ν24, and methyl, ν23, torsional modes and the in-plane bending mode, ν16, of the cis-methyl vinyl ether have been measured and analyzed in the frequency region from 50 to 600 GHz. A significant Fermi-type and Coriolis interactions between the v24=1 and v23=1 states have been observed and the rotational spectra were analyzed using an effective two-state Hamiltonian explicitly involving corresponding coupling operators. A sets of spectroscopic constants for the ground state as well as for all three excited states reproducing the observed spectrum within the experimental uncertainty provide sufficiently precise information for the astronomical search for methyl vinyl ether. Z. Peeters, S. D. Rodgers, S. B. Charnley, L. Schriver-Mazzuoli, A. Schriver, J. V. Keane, and P. Ehrenfreund, Astron. & Astrophys. 2006, 445, 197. G. W. Fuchs, U. Fuchs, T. F. Giesen, F. Wyrowski, Astron. & Astrophys. 2005, 444, 521. B. E. Turner, A. J. Apponi, Astrophys. J. Lett. 2001, 561, 207.

  4. Linear multispecies gyrokinetic flux tube benchmarks in shaped tokamak plasmas

    NASA Astrophysics Data System (ADS)

    Merlo, G.; Sauter, O.; Brunner, S.; Burckel, A.; Camenen, Y.; Casson, F. J.; Dorland, W.; Fable, E.; Görler, T.; Jenko, F.; Peeters, A. G.; Told, D.; Villard, L.

    2016-03-01

    Verification is the fundamental step that any turbulence simulation code has to be submitted in order to assess the proper implementation of the underlying equations. We have carried out a cross comparison of three flux tube gyrokinetic codes, GENE [F. Jenko et al., Phys. Plasmas 7, 1904 (2000)], GKW [A. G. Peeters et al., Comput. Phys. Commun. 180, 2650 (2009)], and GS2 [W. Dorland et al., Phys. Rev. Lett. 85, 5579 (2000)], focusing our attention on the effect of realistic geometries described by a series of MHD equilibria with increasing shaping complexity. To simplify the effort, the benchmark has been limited to the electrostatic collisionless linear behaviour of the system. A fully gyrokinetic model has been used to describe the dynamics of both ions and electrons. Several tests have been carried out looking at linear stability at ion and electron scales, where for the assumed profiles Ion Temperature Gradient (ITG)/Trapped Electron Modes and Electron Temperature Gradient modes are unstable. The capability of the codes to handle a non-zero ballooning angle has been successfully benchmarked in the ITG regime. Finally, the standard Rosenbluth-Hinton test has been successfully carried out looking at the effect of shaping on Zonal Flows (ZFs) and Geodesic Acoustic Modes (GAMs). Inter-code comparison as well as validation of simulation results against analytical estimates has been accomplished. All the performed tests confirm that plasma elongation strongly stabilizes plasma instabilities as well as leads to a strong increase in ZF residual and GAM damping.

  5. Photoluminescence from the Wigner Crystal.

    NASA Astrophysics Data System (ADS)

    Kodiyalam, S.; Price, R.; Fertig, H. A.; Das Sarma, S.

    1996-03-01

    Motivated by recent experiments on radiative recombination of two-dimensional electrons in acceptor δ-doped GaAs/AlGaAs heterojunctions (I.V. Kukushkin, V.I. Falko, R.J. Haug, K. von Klitzing, K. Eberl and K. Totemayer, Phys. Rev. Lett. 72), 3594 (1994) as well as the success of a harmonic solid model (P. Johansson and J.M. Kinaret, Phys. Rev. Lett. 71), 1435 (1993) in describing tunneling between two-dimensional electron systems, we calculate within the harmonic approximation and sudden perturbation theory the photoluminescence spectrum from the recombination process. The potential for both the perturbed and unperturbed hamiltonians is computed using a recent algorithm for molecular dynamics which is expected to result in the classical ground state. (V.A. Schweigert and F.M. Peeters, Phys. Rev. B 51), 7700 (1995) Using the theoretical results of Dodonov and Manko (Proc. Lebedev Phys. Inst., 183), 263 (1987), we are able to include in the perturbation, in addition to changes in the equilibrium positions of electrons, changes in curvatures of the potential. Supported by NSF and the U.S. ONR

  6. Bohr's Semiclassical Model of the Black Hole Thermodynamics

    NASA Astrophysics Data System (ADS)

    Pankovic, V.; Predojevic, M.; Grujic, P.

    2008-06-01

    ekenstein, J. D. 1973, Phys. Rev. D, 7, 2333 Bekenstein, J. D. 1994, gr-qc/9409015v2 Bekenstein, J. D. 1998, gr-qc/9808028v3 Frasca, M. 2005, hep-th/0411245v4 Grujic, P. V. 1993, Bull. Astron. Belgrade, 147, 15 Hawking, S. W. 1975, Comm. Math. Phys., 43, 199 Hawking, S. W. 1979, in "General Relativity, an Einstein Centenary Survey," Eds. S. W. Hawking and W. Israel (Cambridge: Cambridge University Press) Nagatani, Y. 2007, Progr. Theor. Phys. Suppl., 164, 54 Nicolai,H., Peeters, K., & Zamaklar, M. 2005, Class. Quantum Grav., 22, R193 Norcliffe A. 1975, in "Case Studies in Atomic Physics - Vol. 4," Eds. E. W. McDaniel and M. R. McDowell (Amsterdam: North-Holland), 46 Page, D. N. 2004, hep-th/0409024 Pavon, D. 2007, J. Phys. A, 40, 6865 Proline, B. 2006, hep-th/0607227 Ram, B. 2000, Phys. Lett. A, 265, 1 Ram, B., Ram, A, Ram, N. 2005, The Quantum Black Hole, gr-qc/0504030 Samuel, J., & Chowdhury, S. R. 2007, Class. Quantum Grav., 24, F47 Strominger, D. N., Vafa, C. 1996, Phys. Lett. B, 339, 99 Wald, R. M. 1997, gr-qc/9702022 Wald, R. M. 1999, gr-qc/9912119

  7. The influence of the self-consistent mode structure on the Coriolis pinch effect

    SciTech Connect

    Peeters, A. G.; Camenen, Y.; Casson, F. J.; Hornsby, W. A.; Snodin, A. P.; Angioni, C.; Strintzi, D.

    2009-06-15

    This paper discusses the effect of the mode structure on the Coriolis pinch effect [A. G. Peeters, C. Angioni, and D. Strintzi, Phys. Rev. Lett. 98, 265003 (2007)]. It is shown that the Coriolis drift effect can be compensated for by a finite parallel wave vector, resulting in a reduced momentum pinch velocity. Gyrokinetic simulations in full toroidal geometry reveal that parallel dynamics effectively removes the Coriolis pinch for the case of adiabatic electrons, while the compensation due to the parallel dynamics is incomplete for the case of kinetic electrons, resulting in a finite pinch velocity. The finite flux in the case of kinetic electrons is interpreted to be related to the electron trapping, which prevents a strong asymmetry in the electrostatic potential with respect to the low field side position. The physics picture developed here leads to the discovery and explanation of two unexpected effects: First the pinch velocity scales with the trapped particle fraction (root of the inverse aspect ratio), and second there is no strong collisionality dependence. The latter is related to the role of the trapped electrons, which retain some symmetry in the eigenmode, but play no role in the perturbed parallel velocity.

  8. Multiscale Informatics for Low-Temperature Propane Oxidation: Further Complexities in Studies of Complex Reactions.

    PubMed

    Burke, Michael P; Goldsmith, C Franklin; Klippenstein, Stephen J; Welz, Oliver; Huang, Haifeng; Antonov, Ivan O; Savee, John D; Osborn, David L; Zádor, Judit; Taatjes, Craig A; Sheps, Leonid

    2015-07-16

    The present paper describes further development of the multiscale informatics approach to kinetic model formulation of Burke et al. (Burke, M. P.; Klippenstein, S. J.; Harding, L. B. Proc. Combust. Inst. 2013, 34, 547-555) that directly incorporates elementary kinetic theories as a means to provide reliable, physics-based extrapolation of kinetic models to unexplored conditions. Here, we extend and generalize the multiscale informatics strategy to treat systems of considerable complexity-involving multiwell reactions, potentially missing reactions, nonstatistical product branching ratios, and non-Boltzmann (i.e., nonthermal) reactant distributions. The methodology is demonstrated here for a subsystem of low-temperature propane oxidation, as a representative system for low-temperature fuel oxidation. A multiscale model is assembled and informed by a wide variety of targets that include ab initio calculations of molecular properties, rate constant measurements of isolated reactions, and complex systems measurements. Active model parameters are chosen to accommodate both "parametric" and "structural" uncertainties. Theoretical parameters (e.g., barrier heights) are included as active model parameters to account for parametric uncertainties in the theoretical treatment; experimental parameters (e.g., initial temperatures) are included to account for parametric uncertainties in the physical models of the experiments. RMG software is used to assess potential structural uncertainties due to missing reactions. Additionally, branching ratios among product channels are included as active model parameters to account for structural uncertainties related to difficulties in modeling sequences of multiple chemically activated steps. The approach is demonstrated here for interpreting time-resolved measurements of OH, HO2, n-propyl, i-propyl, propene, oxetane, and methyloxirane from photolysis-initiated low-temperature oxidation of propane at pressures from 4 to 60 Torr and

  9. Appendix: Limits on the use of heterodyning and amplification in optical interferometry

    NASA Astrophysics Data System (ADS)

    Burke, Bernard F.

    1992-11-01

    The development of optical fibers, lasers, and mixers at optical frequencies has offered the hope that active methods can contribute to optical interferometry. Heterodyning, in particular, looks attractive, even though bandwidths are narrower than one would like at present; one might expect this limitation to lessen as technology develops. That expectation, unfortunately, is not likely to benefit interferometry at optical wavelengths because of the intervention of quantum mechanics and the second law of thermodynamics, as Burke (1985a) pointed out. So much 'second quantization' noise is generated that only at infrared frequencies, somewhere in the 10-100 micron range, can one look forward to heterodyning in any realistic sense. The reason is easily understood. Every amplifier, in the quantum limit, works by stimulated emission, even though this basic truth is not obvious at radio frequencies. This means that there must be spontaneous emission occurring within every amplifier, and Strandberg (1957) showed that this implied a limiting noise temperature, TN = h nu/k, for any amplifier. Burke (1969) used this result to demonstrate that, if it were not for this quantum noise, the VLBI method would allow one to tell which slit a photon went through before forming an interference pattern, thus violating basic tenants of quantum mechanics. In essence, the second quantization condition Delta N Delta phi greater than or = 1 saves one from paradox. One can state the conclusion simply: any amplifier produces approximately one photon per Hertz of bandwidth. In optical interferometry, one will certainly want bandwidth in the 1012 to 1014 Hz range, and that implies an intolerable cacophony of noise photons. Only at infrared frequencies can one tolerate the quantum noise, where the natural noise background may be high and the mixers are not as efficient as one would hope for. The crossover at present is about 10 or 20 microns, but the boundary will shift to longer wavelengths as

  10. Kinetics of Inhibition of Monoamine Oxidase Using Curcumin and Ellagic Acid

    PubMed Central

    Khatri, Dharmendra Kumar; Juvekar, Archana Ramesh

    2016-01-01

    Background: Curcumin and ellagic are the natural polyphenols having a wide range of pharmacological actions. They have been reported to have their use in various neurological disorders. Objective: This study was aimed to evaluate the effect of curcumin and ellagic acid on the activity of monoamine oxidase (MAO), the enzyme responsible for metabolism of monoamine neurotransmitters which are pivotal for neuronal development and function. Materials and Methods: The in vitro effects of these selected polyphenols on MAO activities in mitochondria isolated from rat brains were examined. Brain mitochondria were assayed for MAO type-B (MAO-B) using benzylamine as substrates. Rat brain mitochondrial MAO preparation was used to study the kinetics of enzyme inhibition using double reciprocal Lineweaver–Burk plot. Results: MAO activity was inhibited by curcumin and ellagic acid; however, higher half maximal inhibitory concentrations of curcumin (500.46 nM) and ellagic acid (412.24 nM) were required compared to the known MAO-B inhibitor selegiline. It is observed that the curcumin and ellagic acid inhibit the MAO activity with both the competitive and noncompetitive type of inhibitions. Conclusions: Curcumin and ellagic acid can be considered a possible source of MAO inhibitor used in the treatment of Parkinson's and other neurological disorders. SUMMARY Monoamine oxidase (MAO) is involved in a variety of neurological disorders including Parkinson's disease (PD)Curcumin and ellagic acid inhibit the monoamine oxidase activityEllagic acid revealed more potent MAO type-B (MAO-B) inhibitory activity than curcuminKinetic studies of MAO inhibition using different concentrations of curcumin and ellagic acid were plotted as double reciprocal Lineweaver–Burk plotThe mode of inhibition of both compounds toward MAO-B is mixed (competitive and uncompetitive) type of inhibition with both the competitive and noncompetitive type of inhibitions. Abbreviations used: MAO: Monoamine oxidase

  11. BSR: B-spline atomic R-matrix codes

    NASA Astrophysics Data System (ADS)

    Zatsarinny, Oleg

    2006-02-01

    BSR is a general program to calculate atomic continuum processes using the B-spline R-matrix method, including electron-atom and electron-ion scattering, and radiative processes such as bound-bound transitions, photoionization and polarizabilities. The calculations can be performed in LS-coupling or in an intermediate-coupling scheme by including terms of the Breit-Pauli Hamiltonian. New version program summaryTitle of program: BSR Catalogue identifier: ADWY Program summary URL:http://cpc.cs.qub.ac.uk/summaries/ADWY Program obtainable from: CPC Program Library, Queen's University of Belfast, N. Ireland Computers on which the program has been tested: Microway Beowulf cluster; Compaq Beowulf cluster; DEC Alpha workstation; DELL PC Operating systems under which the new version has been tested: UNIX, Windows XP Programming language used: FORTRAN 95 Memory required to execute with typical data: Typically 256-512 Mwords. Since all the principal dimensions are allocatable, the available memory defines the maximum complexity of the problem No. of bits in a word: 8 No. of processors used: 1 Has the code been vectorized or parallelized?: no No. of lines in distributed program, including test data, etc.: 69 943 No. of bytes in distributed program, including test data, etc.: 746 450 Peripherals used: scratch disk store; permanent disk store Distribution format: tar.gz Nature of physical problem: This program uses the R-matrix method to calculate electron-atom and electron-ion collision processes, with options to calculate radiative data, photoionization, etc. The calculations can be performed in LS-coupling or in an intermediate-coupling scheme, with options to include Breit-Pauli terms in the Hamiltonian. Method of solution: The R-matrix method is used [P.G. Burke, K.A. Berrington, Atomic and Molecular Processes: An R-Matrix Approach, IOP Publishing, Bristol, 1993; P.G. Burke, W.D. Robb, Adv. At. Mol. Phys. 11 (1975) 143; K.A. Berrington, W.B. Eissner, P.H. Norrington, Comput

  12. Hydroxyl Radical Regeneration in Isoprene Oxidation: the Upgraded Mechanism LIM1

    NASA Astrophysics Data System (ADS)

    Peeters, J.; Nguyen, S.; Nguyen, T.; Stavrakou, T.; Muller, J. J.

    2012-12-01

    Measured hydroxyl radical concentrations in isoprene-rich areas are much higher than predicted by existing chemical models, to the extent that the global oxidizing capacity of our atmosphere should be significantly revised upwards. The OH regeneration that clearly occurs in isoprene oxidation at low/moderate NO is attributed in the Leuven Isoprene Mechanism to novel, theoretically characterized chemical pathways (LIM0: Peeters et al. 2009; Peeters and Muller 2010). The key new features of LIM0 are (i) thermal equilibration of the labile beta-OH- and delta-OH-isoprenylperoxy isomers; (ii) 1,6-H shift isomerisation of the Z-delta-OH-peroxy isomers to yield hydroperoxy-methyl-butenals (HPALDs); (iii) fast photolysis of the HPALDs resulting overall in several OH radicals per HPALD. The OH-regeneration through photolabile HPALDs has recently found experimental support, but the peroxy isomerisation rate, HPALD yield and the extent of OH recycling are still uncertain (Crounse et al. 2011; Wolfe et al. 2012). In this work, the upgraded LIM1 mechanism is presented. Based on better levels of theory, the crucial equilibrium ratio of the isomerising Z-delta-OH-peroxys over the majority beta-OH-isoprenylperoxys had to be reduced by a factor of about 5 compared to LIM0, while the isomerisation rate of the Z-delta-OH-peroxys adopted from Taraborrelli et al. (2012) is about 3 times lower than in LIM0. The chemistry following the 1,6-H shift of the Z-delta-OH-peroxys is much expanded and extended. Firstly, LIM1 introduces other pathways beside HPALD formation following the Z-delta-OH-peroxy isomerisation, resulting likewise in OH recycling. This, together with the revised Z-delta-OH- equilibrium and isomerisation data above, affords a close model-reproduction of the HPALD and other product yields observed by Crounse et al. (2011). Secondly, LIM1 proposes new fast reactions of HO2 with the alpha-oxoketene products from the peroxy isomerisation routes; these reactions are shown to

  13. Hydroxyl radical regeneration in isoprene oxidation: upgraded mechanism LIM1

    NASA Astrophysics Data System (ADS)

    Peeters, Jozef; Son Nguyen, Vinh; Nguyen, Thanh Lam; Stravrakou, Trissevgeni; Muller, Jean-Francois

    2013-04-01

    The OH regeneration known to occur in isoprene oxidation at low/moderate NO is attributed in the Leuven Isoprene Mechanism to novel, theoretically characterized chemical pathways (LIM0: Peeters et al. 2009; Peeters and Muller 2010). Its key new features are (i) quasi-equilibration of the thermally labile beta-OH- and delta-OH-isoprenylperoxy isomers; (ii) 1,6-H shift isomerisation of the Z-delta-OH-peroxy isomers to yield hydroperoxy-methyl-butenals (HPALDs); (iii) fast photolysis of the HPALDs resulting overall in several OH radicals per HPALD. The OH-regeneration through photolabile HPALDs has recently found experimental support, but the peroxy isomerisation rate, HPALD yield and extent of OH recycling are still uncertain (Crounse et al. 2011; Wolfe et al. 2012). In this work, the upgraded LIM1 mechanism is presented. Based on much higher levels of theory that fully account for dispersion effects, the crucial equilibrium ratio of the isomerising Z-delta-OH-peroxys over the majority beta-OH-isoprenylperoxys is reduced by a factor ≈5 and the isomerisation rate of the Z-delta-OH-peroxys by a factor ≈1.5 compared to LIM0. The chemistry following the 1,6-H shift of the Z-delta-OH-peroxys is also much expanded and extended. Firstly, LIM1 introduces other pathways beside HPALD formation following the Z-delta-OH-peroxy isomerisation, but resulting likewise in OH recycling. This, together with the revised Z-delta-OH- equilibrium and isomerisation data above, affords a fair model-reproduction of the HPALD and other product yields observed by Crounse et al. (2011). Secondly, LIM1 proposes new fast reactions of HO2 with the alpha-oxoketene products from the peroxy isomerisation routes; these reactions are shown to efficiently convert HO2 into OH and are prime candidates for the unknown X + HO2 → OH + ... hydroxyl-recycling routes invoked in recent studies (Hofzumahaus et al.2009; Whalley et al. 2011). Modeling results using the IMAGES global CTM will be presented on

  14. Decadal- to biennial scale variability of planktic foraminifera in the northeastern Arabian Sea during the last two millennia: evidence for winter monsoon forcing mechanisms

    NASA Astrophysics Data System (ADS)

    Munz, Philipp; Lückge, Andreas; Siccha, Michael; Kucera, Michal; Schulz, Hartmut

    2015-04-01

    The Asian monsoon system is controlling the hydrologic cycle, and thus the agricultural and economic prosperity of the worlds most densely populated region. Strong and moisture-laden winds from the southwest induce upwelling and significant productivity in the western Arabian Sea during boreal summer. During boreal winter, weaker dry and cold surface winds from the northeast nourish ocean productivity mainly in the northeastern Arabian Sea. Instrumental records spanning the last century are too short to understand how the monsoon system reacts to external forcing mechanisms and to accurately determine its natural variability. Compared to the summer monsoon component, the dynamics of the winter monsoon are virtually unknown, due to the lack of adequate archives that are affected only by winter conditions. Here we present a decadal- to biennial-scale resolution record of past winter monsoon variability over the last two millennia, based on census counts of planktic foraminifera from two laminated sediment cores collected offshore Pakistan. One shorter box core (SO90-39KG) spans the last 250 years with an average ~2-year resolution, whereas the longer piston core (SO130-275KL) spans the last 2,100 years with a 10-year resolution. We use Globigerina falconensis as a faunal indicator for winter conditions, a species that is most abundant during winter in the NE Arabian Sea (Peeters and Brummer, 2002; Schulz et al., 2002). Our results show that during the past 2,100 years G. falconensis varied with significant periodicities centered on ˜ 60, ˜ 53, ˜ 40, ˜ 34 and ˜ 29 years per cycle. Some of these periods closely match cycles that are known from proxy records of solar irradiance, suggesting a solar forcing on winter monsoon variability. During the past 250 years G. falconensis varied in correlation with the (11-year) Schwabe and the (22-year) Hale solar cycles. Furthermore, a significant ˜ 7 year cyclicity could indicate a teleconnection to the El Niño Southern

  15. PREFACE: 21st Latin American Symposium on Solid State Physics (SLAFES XXI)

    NASA Astrophysics Data System (ADS)

    Aguiar, J. Albino

    2014-04-01

    Colombia e-mail: dalandinezt@unal.edu.co Professor Laura T Corredor Bohórquez Departamento de Física Universidade Federal de Pernambuco 50670-901 Recife PE Brazil e-mail: ltcorredorb@df.ufpe.br Professor Arkady Shanenko Departamento de Física Universidade Federal de Pernambuco 50670-901 Recife PE Brazil e-mail: arkadyshanenko@df.ufpe.br Professor Renato F Jardim Instituto de Física Universidade de S\\~ao Paulo CP 66318 S\\~ao Paulo SP Brazil e-mail: rjardim@if.usp.br Professor Francois Peeters Department Fysica Universiteit Antwerpen Groneneborgerlann 171 B-2020, Antwerpen Belgium e-mail: francois.peeters@uantwerpen.be Organizing committee ChairmanCarlos Arturo Parra Vargas Proceedings EditorJosé Albino Aguiar Program ChairJairo Roa-Rojas SecretaryAura Janeth Barón González TreasurerArmando Sarmiento Santos Speaker ChairRafael González Hernández Fernando Naranjo Mayorga David A Landínez Téllez Jesús Oswaldo Morán José Sierra Ortega

  16. The sensitivity of laser induced fluorescence instruments at low pressure to RO2 radicals and the use of this detection method to determine the yield of HO2 during OH-initiated isoprene oxidation

    NASA Astrophysics Data System (ADS)

    Heard, D. E.; Whalley, L. K.; Blitz, M. A.; Seakins, P. W.

    2011-12-01

    a dry air flow at variable positions along the flow-tube; Isoprene was added downstream of the lamp. Theoretical studies (Peeters et al., 2009) suggest an HO2 yield of 0.7 on a time-scale of a few seconds. Results from the recent laboratory studies will be discussed. Fuchs, H., Bohn, B., Hofzumahaus, A., Holland, F., Lu, K., Nehr, S., Rohrer, F., and Wahner, A.: Detection of HO2 by laser-induced fluorescence: Calibration and interferences from RO2 radicals, Atmos Meas Tech Discuss, 4, 1255-1302, 2011. Heard, D. E., and Pilling, M. J.: Measurement of OH and HO2 in the troposphere, Chem Rev, 103, 5163-5198, 2003. Peeters, J., Nguyen, T. L., and Vereecken, L.: HOx radical regeneration in the oxidation of isoprene, Phys Chem Chem Phys, 11, 5935-5939, 2009.

  17. Hydrophysical and hydrochemical features of Lake Issyk-Kul (Kyrgyzstan) as revealed by field survey of June, 2015

    NASA Astrophysics Data System (ADS)

    Zavialov, Peter; Makkaveev, Petr; Rimskiy-Korsakov, Nikolay; Alymkulov, Salmor; Izhitskiy, Alexander

    2016-04-01

    cycle. However, the vertical profiles of dissolved oxygen indicated that the most intense photosynthetic activity took place in the intermediate layers, while in the surface layer it was suppressed, hypothetically, by excessive insolation. The ionic salt content of the Issyk-Kul waters was essentially uniform throughout the water column, which points towards efficient mixing in the cold period. In summer season, temperature stratification was sufficiently strong to provide for significant reduction of dissolved oxygen and increase of nutrients in the bottom layer. Samples collected and analyzed for dissolved methane generally yielded low concentrations below 0.5 μl/l at the surface and 0.2 μl/l in the bottom layer, however, values as high as to 3.9 μl/l were documented in some samples corresponding to near-shore stations at depths of about 70 m. We also used a towed side-looking sonar to obtain detailed maps of bathymetric features, including the channels formed by ancient beds of the Tyup and the Dzhergalan Rivers. These channels are believed to represent important pathways for ventilated water and terrigenic substances penetrating into the deep central part of the lake following seasonal differential cooling on the eastern shelf (Peeters et al., 2003). Quantitative assessment of this plausible mechanism is subject to future work. References Oberhansli, H., and P. Molnar (2012) Climate evolution in Central Asia during the past few million years: A case study from Issyk-Kul. Scientific Drilling, 13, doi: 10.2204/iodp/sd.13.09.2011 Peeters F, Finger D, Hofer M, Brennwald M, Livingstone DM, Kipfer R (2003) Deep-water renewal in Lake Issyk-Kul driven by differential cooling. Limnol. and Oceanogr. 48: 1419- 1431.

  18. Impacts of mechanistic changes on HOx formation and recycling in the oxidation of isoprene

    NASA Astrophysics Data System (ADS)

    Archibald, A. T.; Cooke, M. C.; Utembe, S. R.; Shallcross, D. E.; Derwent, R. G.; Jenkin, M. E.

    2010-09-01

    Recently reported model-measurement discrepancies for the concentrations of the HOx radical species (OH and HO2) in locations characterized by high emission rates of isoprene have indicated possible deficiencies in the representation of OH recycling and formation in isoprene mechanisms currently employed in numerical models; particularly at low levels of NOx. Using version 3.1 of the Master Chemical Mechanism (MCM v3.1) as a base mechanism, the sensitivity of the system to a number of detailed mechanistic changes is examined for a wide range of NOx levels, using a simple box model. The studies consider sensitivity tests in relation to three general areas for which experimental and/or theoretical evidence has been reported in the peer-reviewed literature, as follows: (1) implementation of propagating channels for the reactions of HO2 with acyl and β-oxo peroxy radicals with HO2, with support from a number of studies; (2) implementation of the OH-catalysed conversion of isoprene-derived hydroperoxides to isomeric epoxydiols, as characterised by Paulot et al.~(2009a); and (3) implementation of a mechanism involving respective 1,5 and 1,6 H atom shift isomerisation reactions of the β-hydroxyalkenyl and cis-δ-hydroxyalkenyl peroxy radical isomers, formed from the sequential addition of OH and O2 to isoprene, based on the theoretical study of Peeters et al. (2009). All the considered mechanistic changes lead to simulated increases in the concentrations of OH, with (1) and (2) resulting in respective increases of up to about 7% and 16%, depending on the level of NOx. (3) is found to have potentially much greater impacts, with enhancements in OH concentrations of up to a factor of about 3.3, depending on the level of NOx, provided the (crucial) rapid photolysis of the hydroperoxy-methyl-butenal products of the cis-δ-hydroxyalkenyl peroxy radical isomerisation reactions is represented, as also postulated by Peeters et al.~(2009). Additional tests suggest that the

  19. Global mechanistic model of SOA formation: effects of different chemical mechanisms

    NASA Astrophysics Data System (ADS)

    Lin, G.; Penner, J. E.; Sillman, S.; Taraborrelli, D.; Lelieveld, J.

    2011-09-01

    Recent experimental findings indicate that Secondary Organic Aerosol (SOA) represents an important and, under many circumstances, the major fraction of the organic aerosol burden. Here, we use a global 3-d model (IMPACT) to test the results of different mechanisms for the production of SOA. The basic mechanism includes SOA formation from organic nitrates and peroxides produced from an explicit chemical formulation, using partition coefficients based on thermodynamic principles. We also include the formation of non-evaporative SOA from the reaction of glyoxal and methylglyoxal on aqueous aerosols and cloud droplets as well as from the reaction of epoxides on aqueous aerosols. A model simulation including these SOA formation mechanisms gives an annual global SOA production of 113.5 Tg. The global production of SOA is substantially decreased to 85.0 Tg yr-1 if the HOx regeneration mechanism proposed by Peeters et al. (2009) is used. Model predictions with and without this HOx regeneration scheme are compared with multiple surface observation datasets, namely: the Interagency Monitoring of Protected Visual Environments (IMPROVE) for the United States, the European Monitoring and Evaluation Programme (EMEP) as well as Aerosol Mass Spectrometry (AMS) data measured in both Northern Hemisphere and tropical forest regions. All model simulations realistically predict the organic carbon mass observed in the Northern Hemisphere, although they tend to overestimate the concentrations in tropical forest regions. This overestimate may result from an unrealistically high uptake rate of glyoxal and methylglyoxal on aqueous aerosols and in cloud drops. The modeled OC in the free troposphere is in agreement with measurements in the ITCT-2K4 aircraft campaign over the North America and in pollution layers in Asia during the INTEX-B campaign, although the model underestimates OC in the free troposphere during the ACE-Asia campaign off the coast of Japan.

  20. Pedagogy with babies: perspectives of eight nursery managers

    PubMed Central

    Elfer, Peter; Page, Jools

    2015-01-01

    The last 30 years have seen a significant increase in babies attending nursery, with corresponding questions about the aims and organisation of practice. Research broadly agrees on the importance of emotionally consistent, sensitive and responsive interactions between staff and babies. Policy objectives for nursery and expectations of parents and staff give rise to different and sometimes conflicting aims for such interactions; for example attachments to staff, peer interactions or early learning. Research shows marked variations of pedagogy aims and organisation with babies in nurseries in different national and cultural contexts. It also demonstrates variation between nurseries in similar contexts and between staff in their beliefs and values about work with babies. This paper reports on an exploratory study of the beliefs, aspirations and approaches of eight managers concerning pedagogy with babies in two similar English local authorities. These managers spoke of the importance of being responsive to the concerns and priorities of parents, whilst being sensitive to the demands of the work on their staff. The main finding was of the contradictions and confusions managers felt were inherent in the work, arising from both conflicting policy objectives and personal beliefs and aspirations; sometimes their own and sometimes those of individual staff and parents. Urban, Vandenbroeck, Van Laere, Lazzari, and Peeters' [(2012). Towards competent systems in early childhood education and care. Implications for policy and practice. European Journal of Education, 47(4), 508–526.] concept of the ‘competent system’ is used to recommend a grounded approach to the development of a more culturally, socially and individually responsive pedagogy with babies than appears to exist at present. PMID:26692633

  1. Perturbative studies of toroidal momentum transport using neutral beam injection modulation in the Joint European Torus: Experimental results, analysis methodology, and first principles modeling

    SciTech Connect

    Mantica, P.; Ferreira, J. S.; Salmi, A.; Strintzi, D.; Weiland, J.; Brix, M.; Giroud, C.; Corrigan, G.; Zastrow, K.-D.; Tardini, G.

    2010-09-15

    Perturbative experiments have been carried out in the Joint European Torus [Fusion Sci. Technol. 53(4) (2008)] in order to identify the diffusive and convective components of toroidal momentum transport. The torque source was modulated either by modulating tangential neutral beam power or by modulating in antiphase tangential and normal beams to produce a torque perturbation in the absence of a power perturbation. The resulting periodic perturbation in the toroidal rotation velocity was modeled using time-dependent transport simulations in order to extract empirical profiles of momentum diffusivity and pinch. Details of the experimental technique, data analysis, and modeling are provided. The momentum diffusivity in the core region (0.2<{rho}<0.8) was found to be close to the ion heat diffusivity ({chi}{sub {phi}/{chi}i{approx}}0.7-1.7) and a significant inward momentum convection term, up to 20 m/s, was found, leading to an effective momentum diffusivity significantly lower than the ion heat diffusivity ({chi}{sub {phi}}{sup eff}/{chi}{sub i}{sup eff{approx}}0.4). These results have significant implications on the prediction of toroidal rotation velocities in future tokamaks and are qualitatively consistent with recent developments in momentum transport theory. Detailed quantitative comparisons with the theoretical predictions of the linear gyrokinetic code GKW [A. G. Peeters et al., Comput. Phys. Commun. 180, 2650 (2009)] and of the quasilinear fluid Weiland model [J. Weiland, Collective Modes in Inhomogeneous Plasmas (IOP, Bristol, 2000)] are presented for two analyzed discharges.

  2. Getting from A to B-exploring the activation motifs of the class B adhesion G protein-coupled receptor subfamily G member 4/GPR112.

    PubMed

    Peeters, Miriam C; Mos, Iris; Lenselink, Eelke B; Lucchesi, Martina; IJzerman, Adriaan P; Schwartz, Thue W

    2016-05-01

    The adhesion G protein-coupled receptors [ADGRs/class B2 G protein-coupled receptors (GPCRs)] constitute an ancient family of GPCRs that have recently been demonstrated to play important roles in cellular and developmental processes. Here, we describe a first insight into the structure-function relationship of ADGRs using the family member ADGR subfamily G member 4 (ADGRG4)/GPR112 as a model receptor. In a bioinformatics approach, we compared conserved, functional elements of the well-characterized class A and class B1 secretin-like GPCRs with the ADGRs. We identified several potential equivalent motifs and subjected those to mutational analysis. The importance of the mutated residues was evaluated by examining their effect on the high constitutive activity of the N-terminally truncated ADGRG4/GPR112 in a 1-receptor-1-G protein Saccharomyces cerevisiae screening system and was further confirmed in a transfected mammalian human embryonic kidney 293 cell line. We evaluated the results in light of the crystal structures of the class A adenosine A2A receptor and the class B1 corticotropin-releasing factor receptor 1. ADGRG4 proved to have functionally important motifs resembling class A, class B, and combined elements, but also a unique highly conserved ADGR motif (H3.33). Given the high conservation of these motifs and residues across the adhesion GPCR family, it can be assumed that these are general elements of ADGR function.-Peeters, M. C., Mos, I., Lenselink, E. B., Lucchesi, M., IJzerman, A. P., Schwartz, T. W. Getting from A to B-exploring the activation motifs of the class B adhesion G protein-coupled receptor subfamily G member 4/GPR112. PMID:26823453

  3. Inhibitory effects of ofloxacin and cefepime on enzyme activity of 6-phosphogluconate dehydrogenase from chicken liver.

    PubMed

    Erat, Mustafa; Sakiroğlu, Halis

    2007-01-01

    In this study, effects of some antibiotics, namely, ofloxacin, cefepime, cefazolin, and ampicillin on the in vitro enzyme activity of 6-phosphogluconate dehydrogenase have been investigated. For this purpose, 6-phosphogluconate dehydrogenase was purified from chicken liver 535-fold with a yield of 18% by using ammonium sulphate precipitation, 2',5'-ADP Sepharose 4B affinity chromatography, and Sephadex G-200 gel filtration chromatography. In order to check the purity of the enzyme, SDS polyacylamide gel electrophoresis (SDS-PAGE) was performed. This analysis revealed a highly pure enzyme band on the gel. Among the antibiotics, ofloxacin and cefepime exhibited inhibitory effects, but cefazolin and ampicillin showed neither important inhibitory nor activatory effects on the enzyme activity. The measured I(50) values by plotting activity percent vs. inhibitor concentration, [I(50)] were 0.1713 mM for ofloxacin and 6.0028 mM for cefepime. Inhibition constants, K(i), for ofloxacin and cefepime were also calculated as 0.2740 +/- 0.1080 mM and 12.869 +/- 16.6540 mM by means of Lineweaver-Burk graphs, and inhibition types of the antibiotics were found out to be non-competitive and competitive, respectively. It has been understood from the calculated inhibitory parameters that the purified chicken enzyme has been quite inhibited by these two antimicrobials. PMID:17305608

  4. Ab initio based thermal property predictions at a low cost: An error analysis

    NASA Astrophysics Data System (ADS)

    Lejaeghere, Kurt; Jaeken, Jan; Van Speybroeck, Veronique; Cottenier, Stefaan

    2014-01-01

    Ab initio calculations often do not straightforwardly yield the thermal properties of a material yet. It requires considerable computational efforts, for example, to predict the volumetric thermal expansion coefficient αV or the melting temperature Tm from first principles. An alternative is to use semiempirical approaches. They relate the experimental values to first-principles predictors via fits or approximative models. Before applying such methods, however, it is of paramount importance to be aware of the expected errors. We therefore quantify these errors at the density-functional theory level using the Perdew-Burke-Ernzerhof functional for several semiempirical approximations of αV and Tm, and compare them to the errors from fully ab initio methods, which are computationally more intensive. We base our conclusions on a benchmark set of 71 ground-state elemental crystals. For the thermal expansion coefficient, it appears that simple quasiharmonic theory, in combination with different approximations to the Grüneisen parameter, provides a similar overall accuracy as exhaustive first-principles phonon calculations. For the melting temperature, expensive ab initio molecular-dynamics simulations still outperform semiempirical methods.

  5. Formula optimization of the Jiashitang scar removal ointment and antiinflammatory compounds screening by NF-κB bioactivity-guided dual-luciferase reporter assay system.

    PubMed

    Gao, Jie; Tao, Jin; Zhang, Nannan; Liu, Yanjie; Jiang, Min; Hou, Yuanyuan; Wang, Qian; Bai, Gang

    2015-02-01

    Inflammation plays a role in scar formation; therefore, decreasing inflammation benefits scar removal. Jiashitang scar removal ointment (JST) is a commercially available traditional Chinese medicinal formulation. It is composed of extracts from Carthamus tinctorius L. (Car), Rheum officinale Baill. (Rhe), Salvia miltiorrhiza Beg. (Sal), and Panax notoginseng (Burk.) F. H. Chen (Pan), which are all herbs with potent antiinflammatory activities. Our aims are to optimize the formula of JST and to elucidate its antiinflammatory active components. Response surface methodology was applied to optimize proportions of the four herb extracts. The antiinflammatory effects were evaluated using in vitro and in vivo models. To screen for active components in this formula, a bioactivity-based ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry analysis was performed. After optimization, the antiinflammatory effects of the new formula were significantly superior to the original one. Screening identified 13 active ingredients: a series of saffiomin, emodin, salvianolic acid, tanshinone, and triterpenoid saponin derivatives. These active ingredients were predicted to exert nuclear factor-κB inhibiting effects through MAPK, PI3K/AKT, and NIK-IKK pathways. In conclusion, the original formula was successfully optimized with more potent antiinflammatory activity. These methods can be applied to researches of other formulas. PMID:25363818

  6. Relationship between the lattice constant of {Upsilon} phase and the content of {delta} phase, {gamma}{double_prime} and {gamma}{prime} phases in Inconel 718

    SciTech Connect

    Liu, W.C.; Xiao, F.R.; Yao, M.; Chen, Z.L.; Jiang, Z.Q.; Wang, S.G.

    1997-07-01

    Inconel 718, a Nb-modified nickel-base superalloy has been widely used in gas turbine and related applications due to its good mechanical properties and structural stability at elevated temperatures ({approximately}650 C). The mechanical properties of Inconel 718 depended on the austenite grain size and the size, morphology and content of {delta} phase, {gamma}{double_prime} and {gamma}{prime} phases. In a previous study, the {delta} phase content in Inconel 718 was measured by X-ray diffraction techniques. However, it was difficult to measure the content of {gamma}{double_prime} and {gamma}{prime} phases. M.G. Burke and M.K. Miller determined the composition of the {Upsilon} matrix by using analytical electron microscopy and atom probe field ion microscopy. Their results indicated that the composition of the {Upsilon} matrix changed due to the formation of the various precipitates. The variation in the composition of the {Upsilon} matrix affected the lattice constant of {Upsilon} phase, then the content of {delta} phase, {gamma}{double_prime} and {gamma}{prime} phases was thought to be associated with the lattice constant of {Upsilon} phase. In this paper, the lattice constant of {Upsilon} phase and the content of {delta} phase in Inconel 718 aged at 910 C for different times after cold rolling are measured by X-ray diffraction techniques. The lattice constant of {Upsilon} phase as a function of the content of {delta} phase, {gamma}{double_prime} and {gamma}{prime} phases is derived.

  7. Pallidal stimulation for primary generalised dystonia: effect on cognition, mood and quality of life.

    PubMed

    Jahanshahi, Marjan; Torkamani, Mariam; Beigi, Mazda; Wilkinson, Leonora; Page, Donna; Madeley, Laura; Bhatia, Kailash; Hariz, Marwan; Zrinzo, Ludvic; Limousin, Patricia; Ruge, Diane; Tisch, Stephen

    2014-01-01

    We investigated the effect of pallidal deep brain stimulation (GPi-DBS) in dystonia on cognition, mood, and quality of life and also assessed if DYT1 gene status influenced cognitive outcome following GPi-DBS. Fourteen patients with primary generalized dystonia (PGD) were assessed, measuring their estimated premorbid and current IQ, memory for words and faces, and working memory, language, executive function, and sustained attention, one month before and one year or more after surgery. Changes in mood and behaviour and quality of life were also assessed. There was a significant improvement of dystonia with GPi-DBS (69 % improvement in Burke-Fahn-Marsden score, p < 0.0001). Performance on five cognitive tests either improved or declined at post-surgical follow-up. Calculation of a reliable change index suggested that deterioration in sustained attention on the PASAT was the only reliable change (worse after surgery) in cognition with GPi-DBS. DYT1 gene status did not influence cognitive outcome following GPi-DBS. Depression, anxiety and apathy were not significantly altered, and ratings of health status on the EQ5D remained unchanged. In our sample, GPi-DBS was only associated with an isolated deficit on a test of sustained attention, confirming that GPi-DBS in PGD is clinically effective and safe, without adverse effects on the main domains of cognitive function. The dissociation between GPi-DBS improving dystonia, but not having a significant positive impact on the patients' QoL, warrants further investigation. PMID:24178706

  8. Gas-Phase Folding of a Prototypical Protonated Pentapeptide: Spectroscopic Evidence for Formation of a Charge-Stabilized β-Hairpin.

    PubMed

    Burke, Nicole L; DeBlase, Andrew F; Redwine, James G; Hopkins, John R; McLuckey, Scott A; Zwier, Timothy S

    2016-03-01

    Ultraviolet and infrared-ultraviolet (IR-UV) double-resonance photofragment spectroscopy has been carried out in a tandem mass spectrometer to determine the three-dimensional structure of cryogenically cooled protonated C-terminally methyl esterified leucine enkephalin [YGGFL-OMe+H](+). By comparing the experimental IR spectrum of the dominant conformer with the predictions of DFT M05-2X/6-31+G(d) calculations, a backbone structure was assigned that is analogous to that previously assigned by our group for the unmodified peptide [ Burke, N.L.; et al. Int. J. Mass Spectrom. 2015 , 378 , 196 ], despite the loss of a C-terminal OH binding site that was thought to play an important role in its stabilization. Both structures are characterized by a type II' β-turn around Gly(3)-Phe(4) and a γ-turn around Gly(2), providing spectroscopic evidence for the formation of a β-hairpin hydrogen bonding pattern. Rather than disrupting the peptide backbone structure, the protonated N-terminus serves to stabilize the β-hairpin by positioning itself in a pocket above the turn where it can form H-bonds to the Gly(3) and C-terminus C═O groups. This β-hairpin type structure has been previously proposed as the biologically active conformation of leucine enkephalin and its methyl ester in the nonpolar cell membrane environment [ Naito, A.; Nishimura, K. Curr. Top. Med. Chem. 2004 , 4 , 135 - 143 ]. PMID:26853832

  9. Monitoring dediazoniation product formation by high-performance liquid chromatography after derivatization.

    PubMed

    Bravo-Díaz, Carlos; González-Romero, Elisa

    2003-03-14

    A derivatization protocol that exploits the rapid reaction between arenediazonium ions and a suitable coupling agent followed by high-performance liquid chromatography analyses of the reaction mixture was employed to determine the product distribution, the rate constants for product formation and the association constant of 4-nitrobenzenediazonium, PNBD, ion with beta-cyclodextrin, beta-CD. The derivatization of PNBD with the coupling agent leads to the formation of a stable azo dye that prevents by-side reactions of PNBD with the solvents of the mobile phase, including water, or the metallic parts of the chromatographic system that would eventually lead to erroneous identification and quantification of dediazoniation products. The results show that in the presence of beta-CD, nitrobenzene is formed at the expense of 4-nitrophenol, which is the major product in its absence. The observed rate constants for the interaction between PNBD and beta-CD increase upon increasing [beta-CD] showing a saturation profile indicative of the formation of an inclusion complex between PNBD and beta-CD. By fitting the experimental data to a simplified Lineaweaver-Burk equation, the corresponding association constant and the maximum acceleration rate of beta-CD towards PNBD were estimated. The protocol is applicable under a variety of experimental conditions provided that the rate of the coupling reaction is much faster than that of dediazoniation. PMID:12650254

  10. Quasi-steady stages in the process of premixed flame acceleration in narrow channels

    NASA Astrophysics Data System (ADS)

    Valiev, D. M.; Bychkov, V.; Akkerman, V.; Eriksson, L.-E.; Law, C. K.

    2013-09-01

    The present paper addresses the phenomenon of spontaneous acceleration of a premixed flame front propagating in micro-channels, with subsequent deflagration-to-detonation transition. It has recently been shown experimentally [M. Wu, M. Burke, S. Son, and R. Yetter, Proc. Combust. Inst. 31, 2429 (2007)], 10.1016/j.proci.2006.08.098, computationally [D. Valiev, V. Bychkov, V. Akkerman, and L.-E. Eriksson, Phys. Rev. E 80, 036317 (2009)], 10.1103/PhysRevE.80.036317, and analytically [V. Bychkov, V. Akkerman, D. Valiev, and C. K. Law, Phys. Rev. E 81, 026309 (2010)], 10.1103/PhysRevE.81.026309 that the flame acceleration undergoes different stages, from an initial exponential regime to quasi-steady fast deflagration with saturated velocity. The present work focuses on the final saturation stages in the process of flame acceleration, when the flame propagates with supersonic velocity with respect to the channel walls. It is shown that an intermediate stage may occur during acceleration with quasi-steady velocity, noticeably below the Chapman-Jouguet deflagration speed. The intermediate stage is followed by additional flame acceleration and subsequent saturation to the Chapman-Jouguet deflagration regime. We elucidate the intermediate stage by the joint effect of gas pre-compression ahead of the flame front and the hydraulic resistance. The additional acceleration is related to viscous heating at the channel walls, being of key importance at the final stages. The possibility of explosion triggering is also demonstrated.

  11. Effect of oxygen vacancy on half metallicity in Ni-doped CeO{sub 2} diluted magnetic semiconductor

    SciTech Connect

    Saini, Hardev S. Saini, G. S. S.; Singh, Mukhtiyar; Kashyap, Manish K.

    2015-05-15

    The electronic and magnetic properties of Ni-doped CeO{sub 2} diluted amgentic semiconductor (DMS) including the effect of oxygen vacancy (V{sub o}) with doping concentration, x = 0.125 have been calculated using FPLAPW method based on Density Functional Theory (DFT) as implemented in WIEN2k. In the present supercell approach, the XC potential was constructed using GGA+U formalism in which Coulomb correction is applied to standard GGA functional within the parameterization of Perdew-Burke-Ernzerhof (PBE). We have found that the ground state properties of bulk CeO{sub 2} compound have been modified significantly due to the substitution of Ni-dopant at the cation (Ce) site with/without V{sub O} and realized that the ferromagnetism in CeO{sub 2} remarkably depends on the V{sub o} concentrations. The presence of V{sub o}, in Ni-doped CeO{sub 2}, can leads to strong ferromagnetic coupling between the nearest neighboring Ni-ions and induces a HMF in this compound. Such ferromagnetic exchange coupling is mainly attributed to spin splitting of Ni-d states, via electrons trapped in V{sub o}. The HMF characteristics of Ni-doped CeO{sub 2} including V{sub o} makes it an ideal material for spintronic devices.

  12. The pharmacological mechanism of angiotensin-converting enzyme inhibition by green tea, Rooibos and enalaprilat - a study on enzyme kinetics.

    PubMed

    Persson, Ingrid A-L

    2012-04-01

    Green tea (Camellia sinensis L.) and Rooibos (Aspalathus linearis Dahlg.) inhibit angiotensin-converting enzyme (ACE) in vitro and in vivo. The ACE inhibitor enalaprilat has been described previously as a competitive inhibitor and sometimes as a non-competitive inhibitor. The aim of this study was to investigate the pharmacological mechanism of ACE inhibition of green tea and Rooibos by enzyme kinetics, and to compare this with enalaprilat. A Michaelis-Menten kinetics and Lineweaver-Burk graph showed mean values of V(max)  = 3.73 µM and K(m)  = 0.71 µM for green tea, of V(max)  = 6.76 µM and K(m)  = 0.78 µM for Rooibos, of V(max)  = 12.54 µM and K(m)  = 2.77 µM for enalaprilat, and of V(max)  = 51.33 µM and K(m)  = 9.22 µM for the PBS control. Incubating serum with green tea or Rooibos saturated with zinc chloride did not change the inhibitory effect. Enalaprilat preincubated with zinc chloride showed a decrease in the inhibitory effect. In conclusion, green tea, Rooibos and enalaprilat seem to inhibit ACE activity using a mixed inhibitor mechanism. PMID:22095883

  13. USING RECENT ADVANCES IN 2D SEISMIC TECHNOLOGY AND SURFACE GEOCHEMISTRY TO ECONOMICALLY REDEVELOP A SHALLOW SHELF CARBONATE RESERVOIR: VERNON FIELD, ISABELLA COUNTY, MI.

    SciTech Connect

    James R. Wood; T.J. Bornhorst; William B. Harrison; W. Quinlan

    2002-04-01

    The fault study continues to find more faults and develop new techniques to visualize them. Data from the Dundee Formation has been used to document 11 major faults in the Michigan Basin which have now been verified using data from other horizons. These faults control the locations of many of the large anticlinal structures in the Michigan Basin and likely controlled fluid movements as well. The surface geochemistry program is also moving along well with emphasis on measuring samples collected last sampling season. The new GC laboratory is now functional and has been fully staffed as of December. The annual project review was held March 7-9 in Tampa, Florida. Contracts are being prepared for drilling the Bower's prospects in Isabella County, Michigan, this spring or summer. A request was made to extend the scope of the project to include the Willison Basin. A demonstration well has been suggested in Burke County, N. Dakota, following a review of 2D seismic and surface geochem. A 3D seismic survey is scheduled for the prospect.

  14. USING RECENT ADVANCES IN 2D SEISMIC TECHNOLOGY AND SURFACE GEOCHEMISTRY TO ECONOMICALLY REDEVELOP A SHALLOW SHELF CARBONATE RESERVOIR: VERNON FIELD, ISABELLA COUNTY, MI.

    SciTech Connect

    James R. Wood; W. Quinlan

    2003-07-01

    The principal objective of this demonstration project is to test surface geochemical techniques for detecting trace amounts of light hydrocarbons in pore gases as a means of reducing risk in hydrocarbon exploration and production. As part of the project, a field demonstration was undertaken to assess the validity and usefulness of the microbial surface geochemical technique. The surface geochemistry data showed a strong anomaly in the Myrtle Beach area that would justify drilling by itself and even more so in conjunction with the structural interpretation from the 3D seismic data. The Myrtle Beach geochemical survey indicated a good to excellent prospect which was confirmed by drilling. Presented in this quarterly report is the Case History and Well Summary for the Myrtle Beach area in Burke County, North Dakota. This case history presents the important technical details regarding the geochemistry and the two vertical wells that are part of this field demonstration, and the applicability of these results to other demonstration projects. This format could be duplicated for other demonstration projects and is being used on all subsequent field demonstrations as they near completion.

  15. Magnetic mechanism investigations on K and Mn co-doped diluted magnetic semiconductor (Sr,K)(Zn,Mn)2As2

    NASA Astrophysics Data System (ADS)

    Yang, Jun-Tao; Luo, Shi-Jun; Xiong, Yong-Chen

    2016-06-01

    On the basic of the first-principles calculations with strong-correlated correction, the electronic structures and magnetic properties of a II-II-V based diluted magnetic semiconductor (Sr,K)(Zn,Mn)2As2 are investigated within Perdew-Burke-Ernzerhof generalized gradient approximation. With local spins doped via isovalent (Zn2+, Mn2+) substitutions, Sr(Zn,Mn)2As2 system prefers antiferromagnetic ground state, caused by Mn-Mn superexchange interactions. Via off-stoichiometry (Sr2+, K+) substitutions, holes are introduced into (Sr,K)(Zn,Mn)2As2 system, resulting in the ferromagnetic spin responses for local moments, except for the most nearest neighboring Mn-Mn pair. The ferromagnetism of this diluted magnetic semiconductor originates from the competition between the direct anti-ferromagnetic superexchange interaction and the indirect ferromagnetic coupling mediated by Zener's p - d exchange interaction. Our calculations show that Zener's p - d exchange interaction depends on the location of K dopants. From the investigation on the magnetic properties of Mn clusters, it is found that the reduction of the measured Mn saturation moments is caused by the counteraction of the local moments of the most nearest neighboring Mn-Mn pair.

  16. Observing ben wyckoff: from basic research to programmed instruction and social issues.

    PubMed

    Escobar, Rogelio; Lattal, Kennon A

    2011-01-01

    L. Benjamin Wyckoff's seminal contributions to both psychological theory and application are the subject of this review. Wyckoff started his academic career as a graduate student at Indiana University, where he developed the observing-response procedure under the guidance of B. F. Skinner and C. J. Burke. At the University of Wisconsin-Madison, Wyckoff refined his mathematical theory of secondary reinforcement. This theory was the impetus for his creation of an electronic simulation of a rat running a T maze, one of the first "computer models" of learning. Wyckoff next went to Emory University, leaving there to help create two of the most successful companies dedicated to the advancement of programmed instruction and teaching machines: Teaching Machines, Inc. and the Human Development Institute. Wyckoff's involvement in these companies epitomizes the application of basic behavior-analytic principles in the development of technology to improve education and human relationships. The emergent picture of Wyckoff is that of a man who, through his research, professional work in educational applications of behavioral principles, and active involvement in the civil rights movement of the 1960s, was strongly committed to applying behavioral science to positively influence human behavior change. PMID:22532737

  17. Characteristics of bifunctional acidic endoglucanase (Cel5B) from Gloeophyllum trabeum.

    PubMed

    Kim, Ho Myeong; Lee, Yoon Gyo; Patel, Darshan H; Lee, Kwang Ho; Lee, Dae-Seok; Bae, Hyeun-Jong

    2012-07-01

    The endoglucanase (Cel5B) from the filamentous fungus Gloeophyllum trabeum was cloned and expressed without a signal peptide, and alanine residue 22 converted to glutamine in Pichia pastoris GS115. The DNA sequence of Cel5B had an open reading frame of 1,077 bp, encoding a protein of 359 amino acid residues with a molecular weight of 47 kDa. On the basis of sequence similarity, Cel5B displayed active site residues at Glu-175 and Glu-287. Both residues lost full hydrolytic activity when replaced with alanine through point mutation. The purified recombinant Cel5B showed very high specific activity, about 80- to 1,000-fold and 13- to 70-fold in comparison with other endoglucanases and cellobiohydrolase, on carboxymethylcellulose and filter paper, respectively, at pH 3.5 and 55°C. Cel5B displayed bifunctional characteristics under acidic conditions. The kinetic properties of the enzyme determined using a Lineweaver-Burk plot indicated that Cel5B is a catalytically efficient cellulolytic enzyme. These results suggest that Cel5B has high bifunctional endo- and exoglucanase activity under acidic conditions and is a good candidate for bioconversion of lignocellulose. PMID:22395898

  18. Conformational Change Near the Redox Center of Dihydrolipoamide Dehydrogenase Induced by NAD(+) to Regulate the Enzyme Activity.

    PubMed

    Fukamichi, Tomoe; Nishimoto, Etsuko

    2015-05-01

    Dihydrolipoamide dehydrogenase (LipDH) transfers two electrons from dihydrolipoamide (DHL) to NAD(+) mediated by FAD. Since this reaction is the final step of a series of catalytic reaction of pyruvate dehydrogenase multi-enzyme complex (PDC), LipDH is a key enzyme to maintain the fluent metabolic flow. We reported here the conformational change near the redox center of LipDH induced by NAD(+) promoting the access of the DHL to FAD. The increase in the affinity of DHL to redox center was evidenced by the decrease in K M responding to the increase in the concentration of NAD(+) in Lineweaver-Burk plots. The fluorescence intensity of FAD transiently reduced by the addition of DHL was not recovered but rather reduced by the binding of NAD(+) with LipDH. The fluorescence decay lifetimes of FAD and Trp were prolonged in the presence of NAD(+) to show that FAD would be free from the electron transfer from the neighboring Tyrs and the resonance energy transfer efficiency between Trp and FAD lowered. These results consistently reveal that the conformation near the FAD and the surroundings would be so rearranged by NAD(+) to allow the easier access of DHL to the redox center of LipDH. PMID:25757537

  19. Lithium adsorption on graphite from density functional theory calculations.

    PubMed

    Valencia, Felipe; Romero, Aldo H; Ancilotto, Francesco; Silvestrelli, Pier Luigi

    2006-08-01

    The structural, energetic, and electronic properties of the Li/graphite system are studied through density functional theory (DFT) calculations using both the local spin density approximation (LSDA), and the gradient-corrected Perdew-Burke-Ernzerhof (PBE) approximation to the exchange-correlation energy. The calculations were performed using plane waves basis, and the electron-core interactions are described using pseudopotentials. We consider a disperse phase of the adsorbate comprising one Li atom for each 16 graphite surface cells, in a slab geometry. The close contact between the Li nucleus and the graphene plane results in a relatively large binding energy (larger than 1.1 eV). A detailed analysis of the electronic charge distribution, density difference distribution, and band structures indicates that one valence electron is entirely transferred from the atom to the surface, which gives rise to a strong interaction between the resulting lithium ion and the cloud of pi electrons in the substrate. We show that it is possible to explain the differences in the binding of Li, Na, and K adatoms on graphite considering the properties of the corresponding cation/aromatic complexes. PMID:16869593

  20. Crude Aloe vera Gel Shows Antioxidant Propensities and Inhibits Pancreatic Lipase and Glucose Movement In Vitro.

    PubMed

    Taukoorah, Urmeela; Mahomoodally, M Fawzi

    2016-01-01

    Aloe vera gel (AVG) is traditionally used in the management of diabetes, obesity, and infectious diseases. The present study aimed to investigate the inhibitory potential of AVG against α-amylase, α-glucosidase, and pancreatic lipase activity in vitro. Enzyme kinetic studies using Michaelis-Menten (K m ) and Lineweaver-Burk equations were used to establish the type of inhibition. The antioxidant capacity of AVG was evaluated for its ferric reducing power, 2-diphenyl-2-picrylhydrazyl hydrate scavenging ability, nitric oxide scavenging power, and xanthine oxidase inhibitory activity. The glucose entrapment ability, antimicrobial activity, and total phenolic, flavonoid, tannin, and anthocyanin content were also determined. AVG showed a significantly higher percentage inhibition (85.56 ± 0.91) of pancreatic lipase compared to Orlistat. AVG was found to increase the Michaelis-Menten constant and decreased the maximal velocity (V max) of lipase, indicating mixed inhibition. AVG considerably inhibits glucose movement across dialysis tubes and was comparable to Arabic gum. AVG was ineffective against the tested microorganisms. Total phenolic and flavonoid contents were 66.06 ± 1.14 (GAE)/mg and 60.95 ± 0.97 (RE)/mg, respectively. AVG also showed interesting antioxidant properties. The biological activity observed in this study tends to validate some of the traditional claims of AVG as a functional food. PMID:26880905

  1. Theoretical and experimental studies on wide-band-gap p-type conductive BaCuSeF and related compounds

    NASA Astrophysics Data System (ADS)

    Sakakima, Hiroshi; Nishitani, Mikihiko; Yamamoto, Koichi; Wada, Takahiro

    2015-08-01

    BaCuSeF and related compounds, MCuQF (M = Ba, Sr; Q = Se, S), are known to show p-type conduction. The formation energies of the Cu vacancy ΔH[VCu] in a MCuQF system were computed by first-principles calculation with a generalized gradient approximation (GGA) of the Perdew-Burke-Ernzerhof (PBE) functional as an electron exchange and correlation functional. The density of states (DOS) of BaCuSeF was calculated with the hybrid functional of Heyd-Scuseria-Ernzerhof (HSE) 06. ΔH[VCu] was found to be very small under both the Cu- and Q-rich conditions, which probably contributes to p-type conduction. The electronic structure of BaCuSeF was studied by X-ray photoelectron spectroscopy (XPS) with UV photoelectron yield spectroscopy (UVPYS) and photoemission yield spectroscopy (PYS). The determined depth of the top of the valence band relative to the vacuum level was about 4.9 eV. This value is desirable for applications in compound semiconductor thin-film tandem solar cells since the absorbers of polycrystalline thin-film solar cells, such as CdTe and Cu(In,Ga)Se2, are p-type semiconductors. The DOS of BaCuSeF calculated with the HSE06 functional was almost consistent with the XPS spectrum.

  2. SCAN+rVV10: A promising van der Waals density functional

    NASA Astrophysics Data System (ADS)

    Peng, Haowei; Yang, Zeng-Hui; Sun, Jianwei; Perdew, John

    The newly developed ``strongly constrained and appropriately normed'' (SCAN) meta-generalized-gradient approximation (meta-GGA) can generally improve over the non-empirical Perdew-Burke-Ernzerhof (PBE) GGA not only for strong chemical bonding, but also for the intermediate-range van der Waals (vdW) interaction. However, the long-range vdW interaction is still missing. To remedy this, we propose here pairing SCAN with the non-local correlation part from the rVV10 vdW density functional, with only two empirical parameters. The resulting SCAN+rVV10 yields excellent geometric and energetic results not only for molecular systems, but also for solids and layered-structure materials, as well as the adsorption of benzene on coinage metal surfaces. Especially, SCAN+rVV10 outperforms all current methods with comparable computational efficiencies, accurately reproducing the three most fundamental parameters--the inter-layer binding energies, inter-, and intra-layer lattice constants--for 28 layered-structure materials. Hence, we have achieved with SCAN+rVV10 a promising vdW density functional for general geometries, with minimal empiricism. This work was supported as part of the Center for the Computational Design of Functional Layered Materials, an Energy Frontier Research Center funded by the U.S. Department of Energy, Office of Science, Basic Energy Sciences under Award #.DE-SC0012575.

  3. Effects of isolation on various lymphocyte activities

    SciTech Connect

    Jessop, J.J.

    1986-01-01

    Prolonged exposure of Sprague Dawley male rats to isolation, water scheduling, or their combination resulted in an enhanced lymphocyte proliferative response to mitogen. Time course studies of effects of isolation on mitogenic response of splenic and/or blood T and B lymphocytes and splenic NK cell activity demonstrated a suppression with short term exposure followed by an enhancement with prolonged exposure. Use of immunoperoxidase staining techniques to identify splenic T or T helper cells revealed that prolonged exposure to isolation had no significant effect on the proportion of these cell populations in the spleen. Examination of the data by Lineweaver-Burke plot and plot of the data as % maximum response showed that prolonged exposure to isolation did not alter the sensitivity of the lymphocytes to mitogen. Involvement of corticosteroids and opioid peptides in mediation of the effects of exposure to isolation on lymphocyte activity was assessed by measurement of plasma corticosterone by radioimmunoassay and by examination of the ability of the opioid antagonist naltrexone to alter the effects of isolation on lymphocyte proliferative response to mitogen. Attempts were made to mimic the effects of short-term isolation on lymphocyte activity by morphine sulfate administration.

  4. Assignment of terahertz vibrational modes of L-glutamine using density functional theory within generalized-gradient approximation

    NASA Astrophysics Data System (ADS)

    Zhang, Han; Zhang, Zhao-Hui; Zhao, Xiao-Yan; Zhang, Tian-Yao; Yan, Fang; Shen, Jiang

    2015-07-01

    The crystal structure of L-glutamine is stabilized by a three-dimensional network of intermolecular hydrogen bonds. We utilize plane-wave density functional theory lattice-dynamics calculations within the generalized-gradient approximation (GGA), Perdew-Burke-Ernzerhof (PBE), PBE for solids (PBEsol), PBE with Wu-Cohen exchange (WC), and dispersion-corrected PBE, to investigate the effect of these intermolecular contacts on the absorption spectra of glutamine in the terahertz frequency range. Among these calculations, the solid-state simulated results obtained using the WC method exhibit a good agreement with the measured absorption spectra, and the absorption features are assigned with the help of WC. This indicates that the vibrational modes of glutamine were related to the combination of intramolecular and intermolecular motions, the intramolecular modes were dominated by rocking or torsion involving functional groups; the intermolecular modes mainly result from the translational motions of individual molecules, and the rocking of the hydrogen-bonded functional groups. Project supported by the National Natural Science Foundation of China (Grant Nos. 61302007 and 60977065), the Fundamental Research Funds for the Central Universities of China (Grant No. FRF-SD-12-016A), and the Engineering Research Center of Industrial Spectrum Imaging of Beijing, China.

  5. Structural properties and phase transformations under pressure of XTe compounds (X = Be, Mg, and Ca): The role of the exchange-correlation potential

    NASA Astrophysics Data System (ADS)

    Palomino-Rojas, L. A.; Cocoletzi, Gregorio H.; de Coss, Romeo; Takeuchi, Noboru

    2009-08-01

    We have performed first principles total energy calculations to investigate the structural properties and possible phase transitions under pressure of IIA-VI compounds: BeTe, MgTe and CaTe. We have considered the following possible structures: rock-salt, nickel arsenide, cesium chloride, zinc-blende, and in some cases wurtzite. Calculations are done using the periodic density functional theory. We employ the full potential linearized augmented plane wave method as implemented in the wien2k code. The exchange and correlation potential energies are treated according to the generalized gradient approximation (GGA) using the Perdew, Burke, Ernzerhof (PBE) parameterization, and the local density approximation (LDA). Our results show that the GGA calculations correctly predict the ground state structure of all three binary compounds: zinc-blende for BeTe, wurtzite/zinc-blende for MgTe, and rock-salt for CaTe. Under pressure, BeTe and MgTe transform to the nickel arsenide structure, while CaTe transforms from rock-salt to cesium chloride. Slightly different results are found using the LDA approximation. We discuss the role of the ionicity in the difference between the LDA and GGA results.

  6. Vibrational Recognition of Adsorption Sites for CO on Platinum and Platinum-Ruthenium Surfaces.

    SciTech Connect

    Dabo, Ismaila; Wieckowski, Andrzei; Marzari, Nicola N.

    2007-09-01

    The research described in this product was performed in part in the Environmental Molecular Sciences Laboratory, a national scientific user facility sponsored by the Department of Energy's Office of Biological and Environmental Research and located at Pacific Northwest National Laboratory. We have studied the vibrational properties of CO adsorbed on platinum and platinum-ruthenium surfaces using density-functional perturbation theory within the Perdew-Burke-Ernzerhof generalizedgradient approximation. The calculated C-O stretching frequencies are found to be in excellent agreement with spectroscopic measurements. The frequency shifts that take place when the surface is covered with ruthenium monolayers are also correctly predicted. This agreement for both shifts and absolute vibrational frequencies is made more remarkable by the frequent failure of local and semilocal exchange-correlation functionals in predicting the stability of the different adsorption sites for CO on transition metal surfaces. We have investigated the chemical origin of the C-O frequency shifts introducing an orbital-resolved analysis of the force and frequency density of states, and assessed the effect of donation and backdonation on the CO vibrational frequency using a GGA + molecular U approach. These findings rationalize and establish the accuracy of density-functional calculations in predicting absolute vibrational frequencies, notwithstanding the failure in determining relative adsorption energies, in the strong chemisorption regime.

  7. Theoretical study of the structural phase transition and elastic properties of HfN under high pressures

    NASA Astrophysics Data System (ADS)

    Chen, Long-Qing; Zhu, Jun; Hao, Yan-Jun; Zhang, Lin; Xiang, Gang; Yu, Bai-Ru; Long, Xiao-Jiang

    2014-12-01

    The effect of hydrostatic pressure on the structures of HfN at 0 K was investigated by using the projector augmented wave (PAW) within the Perdew-Burke-Ernzerhof (PBE) form of the generalized gradient approximation (GGA). The transition pressure between NaCl (B1) and CsCl (B2) structures is predicted to be 277.3 GPa. This value is consistent with that reported by Kroll, while in contrast to the results obtained by Ojha et al. and Meenaatci et al. Moreover, the elastic properties of B1-HfN and B2-HfN under high pressures are successfully obtained. It is found that the elastic constants, bulk modulus B, shear modulus G, compressional and shear wave velocities increase monotonically with increasing pressure. The Debye temperature Θ calculated from the elastic constants of HfN is in good agreement with the experimental values. The anisotropies of B1-HfN and B2-HfN at zero pressure have also been discussed.

  8. Neural stem cell transplantation for the treatment of primary torsion dystonia: A case report

    PubMed Central

    Ren, Wen-Qing; Yin, Feng; Zhang, Jian-Ning; Lu, Wang-Sheng; Liang, Ying-Kui; Adlerberth, Josefin; Tian, Zeng-Min

    2016-01-01

    Primary torsion dystonia (PTD) occurs due to a genetic mutation and often advances gradually. Currently, there is no therapy available that is able to inhibit progression. Neural stem cells (NSCs) are being investigated as potential therapies for neurodegenerative diseases, such as stroke and trauma. The present study evaluated the clinical effectiveness of NSC transplantation in an 18-year-old male patient with PTD, to assess the ability of this therapy to inhibit PTD progression. Genetic testing of the patient revealed a mutation in the torsion dystonia-1 (DYT1) gene (907–909 delGAG). NSCs were bilaterally implanted in the globus pallidus of the patient through stereotactic surgery. Prior to surgery, the patient's Burke-Fahn-Marsden dystonia movement score (BFMDMS) was 21, which progressively decreased after surgery to 18, 17, 15 and 13 at 1, 2, 3 and 4 postoperative years, respectively. BFMDMS was improved by 38.1% over the 4 postoperative years. Although computed tomography and magnetic resonance imaging examinations showed no significant changes prior to and following surgery, postoperative brain positron emission tomography scans revealed increased glucose metabolism in the transplanted region. The clinical efficacy of NSC transplantation in this patient suggests its potential for the treatment of DYT1-positive patients with PTD. PMID:27446258

  9. Functional Response, Prey Stage Preference, and Mutual Interference of the Tamarixia triozae (Hymenoptera: Eulophidae) on Tomato and Bell Pepper.

    PubMed

    Yang, Xiang-Bing; Campos-Figueroa, Manuel; Silva, Adrian; Henne, Donald C

    2015-04-01

    The potato psyllid, Bactericera cockerelli (šulc), has been detrimental to potato, tomato, and other solanaceous crop production in many countries. Management of B. cockerelli is dominated by frequent insecticide applications, but other approaches need consideration, including biological control. The sole arrhenotokous ectoparasitoid of nymphal potato psyllids is Tamarixia triozae (Burks) (Hymenoptera: Eulophidae). Here, laboratory evaluations of host stage preference, parasitoid mutual interference, and functional response of T. triozae were conducted with varying host B. cockerelli nymphal stages and densities on both tomato and bell pepper plant leaves. Significant differences in prey stage preferences were found on both host plants. In a no-choice host stage test, significantly greater parasitism of fourth- and fifth-instar B. cockerelli nymphs occurred, and no parasitism of first or second instars was found. Similar preferences were found in a host stage choice test. Effect of mutual interference on per capita female parasitism was significant when confining two or three simultaneously ovipositing female T. triozae adults on a given host density versus solitary females. The per capita search efficiency (s) of female T. triozae was significantly and negatively correlated with T. triozae density. The functional response of T. triozae to nymphal B. cockerelli was a Type III form on both host plants. In addition, host plant type did not exert a significant bottom-up effect on either parasitism or functional response of female T. triozae. The feasibility of using bell pepper as a potential banker plant for T. triozae augmentation is also discussed. PMID:26470152

  10. Aldose reductase inhibitory activity of compounds from Zea mays L.

    PubMed

    Kim, Tae Hyeon; Kim, Jin Kyu; Kang, Young-Hee; Lee, Jae-Yong; Kang, Il Jun; Lim, Soon Sung

    2013-01-01

    Aldose reductase (AR) inhibitors have a considerable therapeutic potential against diabetes complications and do not increase the risk of hypoglycemia. Through bioassay-guided fractionation of an EtOH extract of the kernel from purple corn (Zea mays L.), 7 nonanthocyanin phenolic compounds (compound 1-7) and 5 anthocyanins (compound 8-12) were isolated. These compounds were investigated by rat lens aldose reductase (RLAR) inhibitory assays. Kinetic analyses of recombinant human aldose reductase (rhAR) were performed, and intracellular galactitol levels were measured. Hirsutrin, one of 12 isolated compounds, showed the most potent RLAR inhibitory activity (IC(50), 4.78 μ M). In the kinetic analyses using Lineweaver-Burk plots of 1/velocity and 1/substrate concentration, hirsutrin showed competitive inhibition against rhAR. Furthermore, hirsutrin inhibited galactitol formation in rat lens and erythrocytes sample incubated with a high concentration of galactose; this finding indicates that hirsutrin may effectively prevent osmotic stress in hyperglycemia. Therefore, hirsutrin derived from Zea mays L. may be a potential therapeutic agent against diabetes complications. PMID:23586057

  11. Accurate electronic and chemical properties of 3d transition metal oxides using a calculated linear response U and a DFT + U(V) method

    NASA Astrophysics Data System (ADS)

    Xu, Zhongnan; Joshi, Yogesh V.; Raman, Sumathy; Kitchin, John R.

    2015-04-01

    We validate the usage of the calculated, linear response Hubbard U for evaluating accurate electronic and chemical properties of bulk 3d transition metal oxides. We find calculated values of U lead to improved band gaps. For the evaluation of accurate reaction energies, we first identify and eliminate contributions to the reaction energies of bulk systems due only to changes in U and construct a thermodynamic cycle that references the total energies of unique U systems to a common point using a DFT + U(V ) method, which we recast from a recently introduced DFT + U(R) method for molecular systems. We then introduce a semi-empirical method based on weighted DFT/DFT + U cohesive energies to calculate bulk oxidation energies of transition metal oxides using density functional theory and linear response calculated U values. We validate this method by calculating 14 reactions energies involving V, Cr, Mn, Fe, and Co oxides. We find up to an 85% reduction of the mean average error (MAE) compared to energies calculated with the Perdew-Burke-Ernzerhof functional. When our method is compared with DFT + U with empirically derived U values and the HSE06 hybrid functional, we find up to 65% and 39% reductions in the MAE, respectively.

  12. Self-interaction corrections applied to Mg-porphyrin, C60, and pentacene molecules.

    PubMed

    Pederson, Mark R; Baruah, Tunna; Kao, Der-You; Basurto, Luis

    2016-04-28

    We have applied a recently developed method to incorporate the self-interaction correction through Fermi orbitals to Mg-porphyrin, C60, and pentacene molecules. The Fermi-Löwdin orbitals are localized and unitarily invariant to the Kohn-Sham orbitals from which they are constructed. The self-interaction-corrected energy is obtained variationally leading to an optimum set of Fermi-Löwdin orbitals (orthonormalized Fermi orbitals) that gives the minimum energy. A Fermi orbital, by definition, is dependent on a certain point which is referred to as the descriptor position. The degree to which the initial choice of descriptor positions influences the variational approach to the minimum and the complexity of the energy landscape as a function of Fermi-orbital descriptors is examined in detail for Mg-porphyrin. The applications presented here also demonstrate that the method can be applied to larger molecular systems containing a few hundred electrons. The atomization energy of the C60 molecule within the Fermi-Löwdin-orbital self-interaction-correction approach is significantly improved compared to local density approximation in the Perdew-Wang 92 functional and generalized gradient approximation of Perdew-Burke-Ernzerhof functionals. The eigenvalues of the highest occupied molecular orbitals show qualitative improvement. PMID:27131541

  13. Investigation on binding of nitric oxide to horseradish peroxidase by absorption spectrometry

    NASA Astrophysics Data System (ADS)

    Qiang, Li; Zhu, Shuhua; Ma, Hongmei; Zhou, Jie

    2010-01-01

    Binding of nitric oxide to horseradish peroxidase (HRP) has been investigated by absorption spectrometry in 0.2 M anaerobic phosphate buffer solution (pH 7.4). Based on this binding equilibrium, a model equation for evaluating the binding constant of nitric oxide to HRP is developed and the binding constant is calculated to be (1.55 ± 0.06) × 10 4 M -1, indicating that HRP can form a stable complex with nitric oxide. The type of inhibition by nitric oxide is validated on the basis of studying initial reaction rates of HRP-catalyzed oxidation of guaiacol in the presence of hydrogen peroxide and nitric oxide. The inhibition mechanism is found to follow an apparent non-competitive inhibition by Lineweaver-Burk method. Based on this kinetic mechanism, the binding constant is also calculated to be (5.22 ± 0.06) × 10 4 M -1. The values of the binding constant determined by the two methods are almost identical. The non-competitive inhibition model is also applicable to studying the effect of nitric oxide on other metalloenzymes, which catalyze the two-substrate reaction with the "ping-pong" mechanism.

  14. Rhetorical analysis of Ronald Reagan's November 18, 1981, address on strategic arms reduction

    SciTech Connect

    Preston, C.T. Jr.

    1986-01-01

    Ronald Reagan's addresses, news conferences, and statements on disarmament during his first term form the focus of this dissertation. The rhetoric of the Nuclear Freeze Campaign formed the background for the study of Reagan's response. A November 18, 1981, address before the National Press Club was selected as the representative anecdote for the disarmament rhetoric. Using Kenneth Burke's dramatistic method, the dissertation concludes that Reagan's effective choices in transformation, entitlement, and identification produced a disarmament drama that enabled many American listeners to cope with the arms race. The understandings created by this drama appealed to an audience that had been aroused by the freeze movement about the danger of nuclear war. Reagan's rhetorical choices included transforming the conflict of the people versus the arms race into a conflict between the people and the Soviet threat, entitling a nuclear buildup START to make it appear that reduction goes further than freezing weapons, and identifying with America's desire not to repeat past mistakes of history by promoting a need for a strong Alliance. Reagan reinforced the drama of an arms buildup as a road to peace. These choices, the constraints of freeze member's access to the media, and inconsistencies among freeze appeals, contributed significantly to the current lack of support for a nuclear freeze.

  15. Exploring technical and cultural appeals in strategic risk communication: the Fernald radium case.

    PubMed

    Hamilton, Jennifer Duffield

    2003-04-01

    Risk disputes are often characterized by tensions between technical and cultural understandings of risk and by communication practices that reflect those differing perspectives. This study considers how participants in risk debates draw upon and combine aspects of technical and cultural rationality as broad orientations to risk in expressing their views and formulating persuasive appeals during risk debates. Rhetorical theorist Kenneth Burke's (1984) concept of frames of acceptance is used to analyze a case study involving competing priorities for radium stored at the Fernald site, a former Department of Energy nuclear weapons facility. A rhetorical analysis is conducted using the transcript from a 1995 public meeting during which local residents and a nuclear medicine expert discussed priorities of Fernald site cleanup versus providing radium stored on site for promising cancer research. Two tensions are identified that fostered disagreement among discussants: the first a tension between a local or global context for the controversy and the second a tension between competing definitions of public participation for this issue. This study analyzes the rhetorical strategies by which participants in the Fernald radium debate articulated these tensions and argues that technical and cultural rationality (Plough & Krimsky, 1987) acted as sources of rhetorical invention influencing participants' individual frames of acceptance and the ways they defined and interpreted the situation and crafted persuasive appeals. PMID:12731814

  16. A search for rotating radio transients and fast radio bursts in the Parkes high-latitude pulsar survey

    NASA Astrophysics Data System (ADS)

    Rane, A.; Lorimer, D. R.; Bates, S. D.; McMann, N.; McLaughlin, M. A.; Rajwade, K.

    2016-01-01

    Discoveries of rotating radio transients and fast radio bursts (FRBs) in pulsar surveys suggest that more of such transient sources await discovery in archival data sets. Here we report on a single-pulse search for dispersed radio bursts over a wide range of Galactic latitudes (|b| < 60°) in data previously searched for periodic sources by Burgay et al. We re-detected 20 of the 42 pulsars reported by Burgay et al. and one rotating radio transient reported by Burke-Spolaor. No FRBs were discovered in this survey. Taking into account this result, and other recent surveys at Parkes, we corrected for detection sensitivities based on the search software used in the analyses and the different back-ends used in these surveys and find that the all-sky FRB event rate for sources with a fluence above 4.0 Jy ms at 1.4 GHz to be R = 4.4^{+5.2}_{-3.1} × 10^3 FRBs d-1 sky-1, where the uncertainties represent a 99 per cent confidence interval. While this rate is lower than inferred from previous studies, as we demonstrate, this combined event rate is consistent with the results of all systematic FRB searches at Parkes to date and does not require the need to postulate a dearth of FRBs at intermediate latitudes.

  17. A study of the inhibition of catalase by dipotassium trioxohydroxytetrafluorotriborate K₂[B₃O₃F₄OH].

    PubMed

    Islamovic, Safija; Galic, Borivoj; Milos, Mladen

    2014-10-01

    In the development of boronic acid-based enzyme inhibitors as potential pharmaceutical drugs, dipotassium trioxohydroxytetrafluorotriborate K2[B3O3F4OH] was listed as a promising new therapeutic for treatment of these diseases. The catalase-mediated conversion of hydrogen peroxide, in the presence and absence of K2[B3O3F4OH] was studied. The kinetics conformed to the Michaelis-Menten model. Lineweaver-Burk plots were linear and plotted the family of straight lines intersected on the abscissa indicating non-competitive inhibition of the catalase. It appears that in the absence of inhibitor, catalase operates the best at conditions around pH 7.1 and in the presence of K2[B3O3F4OH] the optimum is around pH 6.2. The uncatalyzed reaction of hydrogen peroxide decomposition generally has a value of activation energy of 75 kJ mole(-1), whereas catalase, in the absence of inhibitor, lowers the value to 11.2 kJ mole(-1), while in the presence 69 mmoles L(-1) of K2[B3O3F4OH] it was 37.8 kJ mole(-1). PMID:24506205

  18. Specific binding and inhibition of 6-benzylaminopurine to catalase: multiple spectroscopic methods combined with molecular docking study.

    PubMed

    Xu, Qin; Lu, Yanni; Jing, Longyun; Cai, Lijuan; Zhu, Xinfeng; Xie, Ju; Hu, Xiaoya

    2014-04-01

    6-Benzylaminopurine (6-BA) is a kind of cytokinin which could regulate the activities of the antioxidant defense system of plants. In this work, its interaction with and inhibition of beef liver catalase have been systematically investigated using spectroscopic, isothermal titration calorimetric and molecular docking methods under physiological conditions. The fluorescence quenching of beef liver catalase (BLC) by 6-BA is due to the formation of 6-BA-BLC complex. Hydrogen bonds and van der Waals interactions play major roles in stabilizing the complex. The Stern-Volmer quenching constant, binding constant, the corresponding thermodynamic parameters and binding numbers were measured. The results of UV-vis absorption, three-dimensional fluorescence, synchronous fluorescence and circular dichroism spectroscopic results demonstrate that the binding of 6-BA results in the micro-environment change around tyrosine (Tyr) and tryptophan (Trp) residues of BLC. The BLC-mediated conversion of H2O2 to H2O and O2, in the presence and absence of 6-BA, was also studied. Lineweaver-Burk plot indicates a noncompetitive type of inhibition. Molecular docking study was used to find the binding sites. PMID:24412785

  19. Is the Wilson Cycle Caused by the Memory Effect of Water?

    NASA Astrophysics Data System (ADS)

    Regenauer-Lieb, K.; van der Lee, S.; Yuen, D. A.

    2003-12-01

    Did the Atlantic close and then re-open ? (Nature, 211, 676-681, 1966). John Tuzo Wilson's cyclical event of opening and closing of ocean basins, later found to be a generally applicable, became the "Wilson cycle" (Dewey, J.F., and Burke, K., Nature, v.249, p.313-316).Whilst the cyclical nature appears to be understood what then breaks and consumes the oceans at roughly the same location? Remnant textural anisotropy, structural damage and intra-crystalline water content are means of long-term plate memory (> 500 Myrs). This explains a predetermined breaking point but can these heterogeneities lead to the formation of a lithosphere scale fault allowing the consumption and the opening of oceans? In a self-consistent theory, driven by gravity and thermal-mechanics, only a very narrow parameter range initiates the contraction master fault through feedback of thermal-mechanics and water weakening. We have shown that the water content in olivine must be above 200 ppm H/Si for subduction intiation to be possible (Science 2001, 294, 578-580). Here, we provide a broader context and show that the same criticality exists for the ocean opening phase. We prove that water storage can be the critical ingredient for the whole history of the Wilson cycle. In a worked example we show an exploratory application, to the Atlantic-Iapetus pair. We also look at possible present day seismological observations focusing on the US-Atlantic margin.

  20. Adsorption of CO2, N2, and CH4 in Cs-exchanged chabazite: A combination of van der Waals density functional theory calculations and experiment study

    NASA Astrophysics Data System (ADS)

    Shang, Jin; Li, Gang; Singh, Ranjeet; Xiao, Penny; Danaci, David; Liu, Jefferson Z.; Webley, Paul A.

    2014-02-01

    The crucial role of dispersion force in correctly describing the adsorption of some typical small-size gas molecules (e.g., CO2, N2, and CH4) in ion-exchanged chabazites has been investigated at different levels of theory, including the standard density functional theory calculation using the Perdew, Burke, and Ernzerhof (PBE) exchange-correlation functional and van der Waals density functional theory (vdWDFT) calculations using different exchange-correlation models - vdW_DF2, optB86b, optB88, and optPBE. Our results show that the usage of different vdWDFT functionals does not significantly change the adsorption configuration or the profile of static charge rearrangement of the gas-chabazite complexes, in comparison with the results obtained using the PBE. The calculated values of adsorption enthalpy using different functionals are compared with our experimental results. We conclude that the incorporation of dispersion interaction is imperative to correctly predict the trend of adsorption enthalpy values, in terms of different gas molecules and Cs+ cation densities in the adsorbents, even though the absolute values of adsorption enthalpy are overestimated by approximate 10 kJ/mol compared with experiments.

  1. Anti-HMG-CoA Reductase, Antioxidant, and Anti-Inflammatory Activities of Amaranthus viridis Leaf Extract as a Potential Treatment for Hypercholesterolemia.

    PubMed

    Salvamani, Shamala; Gunasekaran, Baskaran; Shukor, Mohd Yunus; Shaharuddin, Noor Azmi; Sabullah, Mohd Khalizan; Ahmad, Siti Aqlima

    2016-01-01

    Inflammation and oxidative stress are believed to contribute to the pathology of several chronic diseases including hypercholesterolemia (elevated levels of cholesterol in blood) and atherosclerosis. HMG-CoA reductase inhibitors of plant origin are needed as synthetic drugs, such as statins, which are known to cause adverse effects on the liver and muscles. Amaranthus viridis (A. viridis) has been used from ancient times for its supposedly medically beneficial properties. In the current study, different parts of A. viridis (leaf, stem, and seed) were evaluated for potential anti-HMG-CoA reductase, antioxidant, and anti-inflammatory activities. The putative HMG-CoA reductase inhibitory activity of A. viridis extracts at different concentrations was determined spectrophotometrically by NADPH oxidation, using HMG-CoA as substrate. A. viridis leaf extract revealed the highest HMG-CoA reductase inhibitory effect at about 71%, with noncompetitive inhibition in Lineweaver-Burk plot analysis. The leaf extract showed good inhibition of hydroperoxides, 2,2-diphenyl-1-picrylhydrazyl (DPPH), nitric oxide (NO), and ferric ion radicals in various concentrations. A. viridis leaf extract was proven to be an effective inhibitor of hyaluronidase, lipoxygenase, and xanthine oxidase enzymes. The experimental data suggest that A. viridis leaf extract is a source of potent antioxidant and anti-inflammatory agent and may modulate cholesterol metabolism by inhibition of HMG-CoA reductase. PMID:27051453

  2. Recommendations for gross examination and sampling of surgical specimens of the spleen.

    PubMed

    O'Malley, Dennis P; Louissaint, Abner; Vasef, Mohammad A; Auerbach, Aaron; Miranda, Roberto; Brynes, Russell K; Fedoriw, Yuri; Hudnall, S David

    2015-10-01

    This review examines handling and processing of spleen biopsies and splenectomy specimens with the aim of providing the pathologist with guidance in optimizing examination and diagnosis of splenic disorders. It also offers recommendations as to relevant reporting factors in gross examination, which may guide diagnostic workup. The role of splenic needle biopsies is discussed. The International Spleen Consortium is a group dedicated to promoting education and research on the anatomy, physiology, and pathology of the spleen. In keeping with these goals, we have undertaken to provide guidelines for gross examination, sectioning, and sampling of spleen tissue to optimize diagnosis (Burke). The pathology of the spleen may be complicated in routine practice due to a number of factors. Among these are lack of familiarity with lesions, complex histopathology, mimicry within several types of lesions, and overall rarity. To optimize diagnosis, appropriate handling and processing of splenic tissue are crucial. The importance of complete and accurate clinical history cannot be overstated. In many cases, significant clinical history such as previous lymphoproliferative disorders, hematologic disorders, trauma, etc, can provide important information to guide the evaluation of spleen specimens. Clinical information helps plan for appropriate processing of the spleen specimen. The pathologist should encourage surgical colleagues, who typically provide the specimens, to include as much clinical information as possible. PMID:26143481

  3. Synthesis and First Principles Investigation of HMX/NMP Cocrystal Explosive

    NASA Astrophysics Data System (ADS)

    Lin, He; Zhu, Shun-Guan; Zhang, Lin; Peng, Xin-Hua; LI, Hong-Zhen

    2013-10-01

    1,3,5,7-Tetranitro-l,3,5,7-tetrazocine (HMX)/N-methyl-2-pyrrolidone (NMP) cocrystal explosive was prepared by a solution evaporation method. This cocrystal explosive crystallized in the trigonal system (space group ? ), with cell parameters a = 16.605(8) Å and c = 31.496(4) Å. Theoretical investigations of the formation mechanism of HMX/NMP cocrystal were carried out in Cambridge serial total energy package (CASTEP) based on dispersion-corrected density functional theory (DFT-D) with a plane wave scheme. The exchange-correlation potential was treated with the Perdew-Burke-Ernzerhof function of generalized gradient approximation, and dispersion force was correlated using Grimme's method. The band structure, density of states, projected density of states, and Mulliken populations were calculated at the generalized gradient approximation level. The results showed that the main host-guest interactions in HMX/NMP cocrystal were hydrogen bonds and stacking interactions, which were the same as those analyzed using X-ray diffraction. Theoretical investigations of HMX/NMP cocrystal explosive may provide the basis for the preparation of cocrystal explosive composed of HMX and energetic materials.

  4. New carbosilane polymers with interacting ferrocenes as support and bioelectrocatalysts of oxidases to develop versatile and specific amperometric biodevices.

    PubMed

    Armada, M Pilar García; Jiménez, Almudena; Losada, José; Alonso, Beatriz; Casado, Carmen M

    2012-12-01

    In this work, the bioelectrocatalytical properties and kinetic characteristics of new oxidase amperometric biosensors based on two different ferrocene functionalized carbosilane polymers, polydiallylmethylsilane (PDAMS) and polymethyldiundecenylsilane (PMDUS) are described. In the development of these biodevices, glucose oxidase has been used as example of oxidase enzyme, and two different immobilization procedures have been studied. The polymer-modified electrodes act as efficient transducers for glucose sensing in anodic and cathodic aerobic conditions and also in anodic anaerobic conditions, and this fact turns them into useful devices for a wide field of applications. PMDUS has shown to be the bioelectrocatalyst with best kinetic and analytical properties in aerobic media while PDAMS was better in anaerobic conditions. The best aerobic biosensor developed displayed a strictly linear range from 0 to 3.0 mM, a detection limit of 7.8 μM and a response time less than 2 s in an ascorbate interference free work potential interval. The apparent Michaelis-Menten constant was calculated to be 1.36 mM according to the Lineweaver-Burk equation. PMID:22971836

  5. Catalytic activity and stability of glucose oxidase/horseradish peroxidase co-confined in macroporous silica foam.

    PubMed

    Cao, Xiaodong; Li, Ying; Zhang, Zhiqiang; Yu, Jiachao; Qian, Jing; Liu, Songqin

    2012-12-21

    Investigation of the catalytic activity and stability of enzymes in confined nano/microspace provides valuable contributions to the fundamental understanding of biological reactions taking place on a mesoscopic scale within confined spaces. In this paper, macroporous silica foam (MSF) is used as a nanoreactor to co-confine glucose oxidase (GOD) and horseradish peroxidase (HRP). Then, the enzymatic cascade reactions, which act in tandem inside nanoreactors, for oxidation of glucose and 3,3',5,5'-tetramethylbenzidine (TMB) were studied. The catalytic kinetic parameters of apparent Michaelis constant (K(m)(app)) and maximum rate (V(max)) were obtained from Lineweaver-Burk plot by UV-vis spectrometry. Results showed that the catalytic activity of the co-confined enzymes is reduced compared to that of free enzymes in solution at room temperature. The stabilities of co-confined enzymes in denaturing agents, such as guanidinium chloride (GdmCl) and urea, were higher than those of free enzymes in solution. When employing a co-confined bienzyme system as a biosensor for the detection of glucose, a wider linear range of glucose was obtained for the co-confined bienzyme system than for free enzymes in solution. PMID:23096254

  6. Synthesis and evaluation of 1-hydroxy/methoxy-4-methyl-2-phenyl-1H-imidazole-5-carboxylic acid derivatives as non-purine xanthine oxidase inhibitors.

    PubMed

    Chen, Shaolei; Zhang, Tingjian; Wang, Jian; Wang, Fangyang; Niu, Handong; Wu, Chunfu; Wang, Shaojie

    2015-10-20

    Xanthine oxidase is a key enzyme that catalyses hypoxanthine and xanthine to uric acid, whose overproduction leads to the gout-causing hyperuricemia. In this study, a series of 1-hydroxy/methoxy-4-methyl-2-phenyl-1H-imidazole-5-carboxylic acid derivatives (4a-4k and 6a-6k) was synthesized and evaluated for their inhibitory potency against xanthine oxidase. The 1-hydroxyl substituted derivatives 4a-4k showed excellent inhibitory potency with IC50 values ranging from 0.003 μM to 1.2 μM, with compounds 4d (IC₅₀ = 0.003 μM), 4e (IC₅₀ = 0.003 μM), and 4f (IC₅₀ = 0.006 μM) manifesting the most potent xanthine oxidase inhibitory potency that were comparable with that of Febuxostat (IC₅₀ = 0.01 μM). Lineweaver-Burk plot analysis revealed that representative compound 4f acted as a mixed-type inhibitor for xanthine oxidase. The basis of significant inhibition of xanthine oxidase by 4f was rationalized by its molecular docking into the active site of xanthine dehydrogenase. PMID:26363870

  7. Structural and magnetic properties of MnPd/Fe grown on MgO(100) substrate: Ab initio studies

    NASA Astrophysics Data System (ADS)

    Malonda-Boungou, B. R.; Magnoungou, J. H. J.; M'Passi-Mabiala, B.; Demangeat, C.

    2016-07-01

    Structural and magnetic properties of ultrathin films MnPd/Fe grown on MgO(001) are investigated using a self-consistent pseudopotential plane waves method based on density functional theory in the Perdew-Burke-Ernzerhof generalized gradient approximation. The results obtained reveal the presence of an antiferromagnetic coupling between successive Mn [100] rows, combined with a ripple where Mn outward atoms exhibit a positive magnetic moment, in the case of Mn overlayer on Fe/MgO(001). In the case of MnPd monolayer ordered alloy, the c(2 × 2) structure formation is more favorable than the p(1 × 2) one, exhibiting a ferromagnetic coupling between Mn neighbor atoms with a positive induced ferromagnetic moment on Pd atoms. Pd atoms are pushed outward. For 1-ML MnxPd1 - x on Fe/MgO, the Mn absolute mean magnetization per atom increases as x coverage increases, whereas the Pd mean induced magnetic moment decreases. For systems alternating Mn and Pd monolayers on Fe/MgO(001), a complex magnetic structure is shown on Mn monolayers: changing from Mn neighboring antiferromagnetic coupling to Mn [010] rows antiferromagnetic behavior. The correlation is made between the electronic structure and the magnetic properties, by comparing filled with partially filled components (Pd, Mn and Fe) d-bands. The magnetization easy-axis changes between the in-plane and the out-of-plane orientations from Fe/MgO to MnPd/Fe/MgO systems.

  8. Influence of microwave irradiation on enzyme kinetics

    NASA Astrophysics Data System (ADS)

    Pavelkić, V. M.; Stanisavljev, D. R.; Gopčević, K. R.; Beljanski, M. V.

    2009-09-01

    The in vitro effect of 2.45 GHz microwave irradiation on porcine pepsin activity under controlled temperature and absorbed microwave power via kinetic parameters was evaluated. Kinetic study with respect of time of irradiation demonstrated the existence of an inactivation effect of microwaves at pH 2 on pepsin molecule. Bovine serum albumin (BSA)-bromphenol blue (BPB) complex was used as substrate for the assay of pepsin by kinetic method. Depending on absorbed microwave dose, the degree of caused inactivation varies from 39.11 to 45.91% for 5 and 20 min of pepsin MW irradiation, respectively. The V maxapp and K mapp were calculated for low (5 min of MW irradiation) and higher specific absorbed dose (20 min of MW irradiation), as well as for untreated enzyme, from double reciprocal Lineweaver-Burk plot. The effect of microwaves on substrate (BSA-BPB complex) was also investigated. For reaction performed with MW irradiated substrate for 5 min the reaction rate was decreased for 15.15%, while for 20 min of substrate irradiation reaction rate was decreased for 25.52% compared to the control reaction.

  9. Extracellular α-Galactosidase from Trichoderma sp. (WF-3): Optimization of Enzyme Production and Biochemical Characterization

    PubMed Central

    Chauhan, Aishwarya Singh; Kumar, Arunesh; Siddiqi, Nikhat J.; Sharma, B.

    2015-01-01

    Trichoderma spp. have been reported earlier for their excellent capacity of secreting extracellular α-galactosidase. This communication focuses on the optimization of culture conditions for optimal production of enzyme and its characterization. The evaluation of the effects of different enzyme assay parameters such as stability, pH, temperature, substrate concentrations, and incubation time on enzyme activity has been made. The most suitable buffer for enzyme assay was found to be citrate phosphate buffer (50 mM, pH 6.0) for optimal enzyme activity. This enzyme was fairly stable at higher temperature as it exhibited 72% activity at 60°C. The enzyme when incubated at room temperature up to two hours did not show any significant loss in activity. It followed Michaelis-Menten curve and showed direct relationship with varying substrate concentrations. Higher substrate concentration was not inhibitory to enzyme activity. The apparent Michaelis-Menten constant (Km), maximum rate of reaction (Vmax), Kcat, and catalytic efficiency values for this enzyme were calculated from the Lineweaver-Burk double reciprocal plot and were found to be 0.5 mM, 10 mM/s, 1.30 U mg−1, and 2.33 U mg−1 mM−1, respectively. This information would be helpful in understanding the biophysical and biochemical characteristics of extracellular α-galactosidase from other microbial sources. PMID:26609435

  10. Recovery of Whey Proteins and Enzymatic Hydrolysis of Lactose Derived from Casein Whey Using a Tangential Flow Ultrafiltration Module

    NASA Astrophysics Data System (ADS)

    Das, Bipasha; Bhattacharjee, Sangita; Bhattacharjee, Chiranjib

    2013-09-01

    In this study, ultrafiltration (UF) of pretreated casein whey was carried out in a cross-flow module fitted with 5 kDa molecular weight cut-off polyethersulfone membrane to recover whey proteins in the retentate and lactose in the permeate. Effects of processing conditions, like transmembrane pressure and pH on permeate flux and rejection were investigated and reported. The polarised layer resistance was found to increase with time during UF even in this high shear device. The lactose concentration in the permeate was measured using dinitro salicylic acid method. Enzymatic kinetic study for lactose hydrolysis was carried out at three different temperatures ranging from 30 to 50 °C using β-galactosidase enzyme. The glucose formed during lactose hydrolysis was analyzed using glucose oxidase-peroxidase method. Kinetics of enzymatic hydrolysis of lactose solution was found to follow Michaelis-Menten model and the model parameters were estimated by Lineweaver-Burk plot. The hydrolysis rate was found to be maximum (with Vmax = 5.5091 mmol/L/min) at 30 °C.

  11. The Effect of Organic Solvents and Other Parameters on Trypsin-Catalyzed Hydrolysis of Na-Benzoyl-arginine-p-nitroanilide. A Project-Oriented Biochemical Experiment

    NASA Astrophysics Data System (ADS)

    Correia, L. C.; Bocewicz, A. C.; Esteves, S. A.; Pontes, M. G.; Versieux, L. M.; Teixeira, S. M. R.; Santoro, M. M.; Bemquerer, M. P.

    2001-11-01

    The study of enzymatic catalysis is a classical biochemistry experiment for undergraduate classes. We propose the utilization of the serine protease trypsin to discuss several parameters affecting enzyme catalysis. Hydrolysis of the chromogenic substrate Na -benzoyl-arginine-p-nitroanilide (BApNA) was followed by spectrophotometric monitoring. The optimal pH and temperature values were found to be 8.0 and 40 °C, respectively. Km and Vmax values were obtained by adjustment to Michaelis-Menten, Lineweaver-Burke, and Hanes equations. We then investigated the effect of organic solvents (a series of alcohols) on the hydrolysis of the chromogenic substrate. The reaction rate was reduced in the presence of methanol and further reduced by ethanol, 1-propanol, and 2-propanol, when compared to the data obtained with buffer. Finally the students were asked to measure the molar absorptivity of p-nitrophenol in the presence of the alcohols employed for the kinetic experiments. Thus they could learn that the value of this parameter varies with the solvent. These experiments were designed as a project-oriented approach to teach biochemistry methodologies and theoretical aspects of enzyme kinetics. They took about four months with four to six hours per week spent in the laboratory.

  12. Benchmarking dispersion and geometrical counterpoise corrections for cost-effective large-scale DFT calculations of water adsorption on graphene.

    PubMed

    Lorenz, Marco; Civalleri, Bartolomeo; Maschio, Lorenzo; Sgroi, Mauro; Pullini, Daniele

    2014-09-15

    The physisorption of water on graphene is investigated with the hybrid density functional theory (DFT)-functional B3LYP combined with empirical corrections, using moderate-sized basis sets such as 6-31G(d). This setup allows to model the interaction of water with graphene going beyond the quality of classical or semiclassical simulations, while still keeping the computational costs under control. Good agreement with respect to Coupled Cluster with singles and doubles excitations and perturbative triples (CCSD(T)) results is achieved for the adsorption of a single water molecule in a benchmark with two DFT-functionals (Perdew/Burke/Ernzerhof (PBE), B3LYP) and Grimme's empirical dispersion and counterpoise corrections. We apply the same setting to graphene supported by epitaxial hexagonal boron nitride (h-BN), leading to an increased interaction energy. To further demonstrate the achievement of the empirical corrections, we model, entirely from first principles, the electronic properties of graphene and graphene supported by h-BN covered with different amounts of water (one, 10 water molecules per cell and full coverage). The effect of h-BN on these properties turns out to be negligibly small, making it a good candidate for a substrate to grow graphene on. PMID:25056422

  13. Two-dimensional boron nitride structures functionalization: first principles studies.

    PubMed

    Ponce-Pérez, R; Cocoletzi, Gregorio H; Takeuchi, Noboru

    2016-09-01

    Density functional theory calculations have been performed to investigate two-dimensional hexagonal boron nitride (2D hBN) structures functionalization with organic molecules. 2x2, 4x4 and 6x6 periodic 2D hBN layers have been considered to interact with acetylene. To deal with the exchange-correlation energy the generalized gradient approximation (GGA) is invoked. The electron-ion interaction is treated with the pseudopotential method. The GGA with the Perdew-Burke-Ernzerhoff (PBE) functionals together with van der Waals interactions are considered to deal with the composed systems. To investigate the functionalization two main configurations have been explored; in one case the molecule interacts with the boron atom and in the other with the nitrogen atom. Results of the adsorption energies indicate chemisorption in both cases. The total density of states (DOS) displays an energy gap in both cases. The projected DOS indicate that the B-p and N-p orbitals are those that make the most important contribution in the valence band and the H-s and C-p orbitals provide an important contribution in the conduction band to the DOS. Provided that the interactions of the acetylene with the 2D layer modify the structural and electronic properties of the hBN the possibility of structural functionalization using organic molecules may be concluded. PMID:27566317

  14. Structural and electronic properties of metalloporphyrin (MP, M = Fe, Co and Zn) adsorbed on single walled BNNT and SiCNT

    NASA Astrophysics Data System (ADS)

    Rezvani, M.; Darvish Ganji, M.; Jameh-Bozorghi, S.

    2016-01-01

    In the present work, we report a detailed theoretical investigation of a series of metalloporphyrin, MP (M = FeP, CoP and ZnP), molecules interacting with silicon carbide nanotube (SiCNT) by means of density functional theory (DFT) calculations. In all calculations, we used the Perdew-Burke-Erzenhof (PBE) functional as employed in the SIESTA package. The detailed analysis of the structural and electronical properties of various optimized configurations is performed. The results show that among the MPs, adsorption of FeP molecule on the Si site with zigzag orientation is the most energetically preferable with a binding energy of -2.10 eV. Compared to SiCNTs, boron nitride nanotubes (BNNTs) have weaker interaction strength with the FeP molecule with -0.34 eV of binding energy. We have analyzed charge transfer between two interacting species trough well-known Mulliken, Hirshfeld and Voronoi charges analysis for aforementioned systems. The spin-polarized DFT calculations showed that the density of states (DOSs) are spin-polarized for the Fe-BNNT complex while the spin-polarization of the DOS spectra turn out to be less notable for MP-SiCNT complexes. Our results propose that FeP-SiCNT complex could be used for interesting applications in solar cell technology and nano-biosensors while FeP-BNNT complex might be considered for spintronic molecular devices.

  15. Theoretical insight into the sensitive mechanism of multilayer-shaped cocrystal explosives: compression and slide.

    PubMed

    Gao, Hong-fei; Zhang, Shu-hai; Ren, Fu-de; Gou, Rui-jun; Han, Gang; Wu, Jing-bo; Ding, Xiong; Zhao, Wen-hu

    2016-05-01

    Multilayer-shaped compression and slide models were employed to investigate the complex sensitive mechanisms of cocrystal explosives in response to external mechanical stimuli. Here, density functional theory (DFT) calculations implementing the generalized gradient approximation (GGA) of Perdew-Burke-Ernzerhof (PBE) with the Tkatchenko-Scheffler (TS) dispersion correction were applied to a series of cocrystal explosives: diacetone diperoxide (DADP)/1,3,5-trichloro-2,4,6-trinitrobenzene (TCTNB), DADP/1,3,5-tribromo-2,4,6-trinitrobenzene (TBTNB) and DADP/1,3,5-triiodo-2,4,6-trinitrobenzene (TITNB). The results show that the GGA-PBE-TS method is suitable for calculating these cocrystal systems. Compression and slide models illustrate well the sensitive mechanism of layer-shaped cocrystals of DADP/TCTNB and DADP/TITNB, in accordance with the results from electrostatic potentials and free space per molecule in cocrystal lattice analyses. DADP/TCTNB and DADP/TBTNB prefer sliding along a diagonal direction on the a-c face and generating strong intermolecular repulsions, compared to DADP/TITNB, which slides parallel to the b-c face. The impact sensitivity of DADP/TBTNB is predicted to be the same as that of DADP/TCTNB, and the impact sensitivity of DADP/TBTNB may be slightly more insensitive than that of DADP and much more sensitive than that of TBTNB. PMID:27094730

  16. Competitive metabolism of naphthalene, methylnaphthalenes, and fluorene by phenanthrene-degrading pseudomonads.

    PubMed Central

    Stringfellow, W T; Aitken, M D

    1995-01-01

    Polynuclear aromatic hydrocarbons (PAHs) typically exist as complex mixtures in contaminated soils, yet little is known about the biodegradation of PAHs in mixtures. We have isolated two physiologically diverse bacteria, Pseudomonas stutzeri P-16 and P. saccharophila P-15, from a creosote-contaminated soil by enrichment on phenanthrene as the sole carbon source and studied their ability to metabolize several other two- and three-ring PAHs. Naphthalene, 1-methylnaphthalene, and 2-methylnaphthalene served as growth substrates for both organisms, while fluorene was only cometabolized. We also studied the effects of these compounds on initial rates of phenanthrene uptake in binary mixtures. Lineweaver-Burk analysis of kinetic measurements was used to demonstrate competitive inhibition of phenanthrene uptake by all four compounds, suggesting that multiple PAHs are being transformed by a common enzyme pathway in whole cells. Estimates of the inhibition coefficient, Ki, are reported for each compound. The occurrence of competitive metabolic processes in physiologically diverse organisms suggests that competitive metabolism may be a common phenomenon among PAH-degrading organisms. PMID:7887615

  17. Addition-fragmentation reaction of thionoesters compounds in free-radical polymerisation (methyl, cyanomethyl and styryl): a theoretical interpretation

    NASA Astrophysics Data System (ADS)

    Hannachi, Douniazed; Ouddai, Nadia; Arotçaréna, Michel; Chermette, Henry

    2015-07-01

    A joint experimental and theoretical study has been carried out on reversible addition-fragmentation chain transfer polymerisation (RAFT). We have performed density functional theory calculations at the (Perdew-Burke-Ernzerhof) PBE/triple zeta plus polarisation level to analyse the RAFT mechanisms corresponding to these compounds. Global and local reactivity indices have been calculated to investigate the effect of the addition of methyl, cyanomethyl and styryl radicals on the double bond C=S of thionoester compounds producing an adduct radical. This mechanism is shown to be difficult when the cyanomethyl is used contrarily to the methyl and styryl radicals, in agreement with experimental results. The activation barrier of fragmentation of adduct radicals does not correlate well with the length of fragmented bond (O-Cα). The bond topological analysis of radical adduct predicts that the distance between the oxygen and a critical point (O-CP) in the fragment bond is a good parameter to estimate the activation energy of the fragmentation mechanism. It is shown that the nature of the free radicals is more selective than that of the thionoester compounds. With an overall large agreement with experiments, these theoretical results afford an explanation of the efficiency for the RAFT mechanism.

  18. Investigation of pure and Co2+-doped ZnO quantum dot electronic structures using the density functional theory: choosing the right functional

    NASA Astrophysics Data System (ADS)

    Badaeva, Ekaterina; Feng, Yong; Gamelin, Daniel R.; Li, Xiaosong

    2008-05-01

    The electronic structures of pure and Co2+-doped ZnO quantum dots (QDs) with sizes up to 300 atoms were investigated using three different density functional theory approximations: local spin density approximation (LSDA), gradient-corrected Perdew-Burke-Ernzerhof (PBE) and the hybrid PBE1 functionals with LANL2DZ pseudo-potential and associated basis set. Qualitative agreement among the three methods is found for the pure ZnO nanostructures, but only the hybrid functional reproduces the correct bandgap energies quantitatively. For Co2+-doped ZnO QDs, both LSDA and PBE incorrectly model interactions between Co2+ d levels and the valence band of ZnO, which will strongly impair predictions of dopant-carrier magnetic exchange interactions based on such computational results. Experimental observations are reproduced well in calculations at the hybrid PBE1 level of theory, making this the method of choice for exploring the magnetism of transition metal ions in ZnO QDs computationally. The qualitative features of the Co2+ 3d levels do not change appreciably with changes in cluster size over the range examined, leading to size-dependent dopant-band edge energy differences. The results presented here thus provide an experimentally calibrated framework for future ab initio descriptions of dopant-carrier and dopant-dopant magnetic exchange interactions in diluted magnetic semiconductors (DMS) nanocrystals.

  19. Bridge Structure for the graphene/Ni(111) system: A first principles study

    SciTech Connect

    Fuentes-Cabrera, Miguel A; Baskes, Mike I.; Melechko, Anatoli Vasilievich; Simpson, Michael L

    2008-01-01

    The structure of graphene on Ni(111) is studied with density functional theory (DFT). Six different structures, i.e., top-fcc, top-hcp, hcp-fcc, bridge-top, bridge-fcc, and bridge-hcp, were investigated. Bridge-top, bridge-fcc, and bridge-hcp are studied here. Top-fcc and hcp-fcc have been considered before, experimentally and theoretically, and regarded as energetically stable structures. The calculations employed the local density approximation (LDA) and the Perdew, Burke, and Ernzerhof (PBE) generalized-gradient approximation to DFT. The results showed that with PBE, none of the structures is stable at the experimentally relevant temperatures; with LDA, only bridge-top and top-fcc are stable. These findings suggest that it will be worthwhile to carry on new experimental studies to revisit the structural determination of the graphene/Ni(111) system, with special emphasis on testing whether bridge-top could exist by itself or coexist with other structures.

  20. Density functional theory study on the magnetic properties of Co3O4 with normal spinel structure

    NASA Astrophysics Data System (ADS)

    Lima, A. F.

    2016-04-01

    The magnetic properties of Co3O4 with a normal spinel structure were investigated via the full potential linearized augmented plane wave (FP-LAPW) method based on density functional theory (DFT). The exchange and correlation effects between electrons were treated with a standard generalized gradient approximation (GGA) from Perdew-Burke-Ernzerhof (PBE), as a function of the on-site Coulomb U term, the GGA-PBE+U method, and a B3PW91 hybrid functional with different Hartree-Fock exchange admixtures. Were calculated all of these exchange-correlation (XC) functionals both with and without spin-orbit coupling (SOC). The objective for these calculations was to predict the ground-state magnetic structure of Co3O4 crystal using different XC functionals and to investigate the influence that SOC had on these results. All of our calculations confirmed that the collinear antiferromagnetic (AFM) order was energetically more favorable than the ferromagnetic (FM) one, which agrees with experimental findings. This conclusion was not influenced by the XC functional type employed or whether the spin-orbit effect was used. Thus, the present work does not confirm the recent DFT plane wave pseudopotential results that when including spin-orbit effects, the calculations determined that the collinear FM state had lower energy than the AFM one.

  1. Regular surface layer of Azotobacter vinelandii.

    PubMed Central

    Bingle, W H; Doran, J L; Page, W J

    1984-01-01

    Washing Azotobacter vinelandii UW1 with Burk buffer or heating cells at 42 degrees C exposed a regular surface layer which was effectively visualized by freeze-etch electron microscopy. This layer was composed of tetragonally arranged subunits separated by a center-to-center spacing of approximately 10 nm. Cells washed with distilled water to remove an acidic major outer membrane protein with a molecular weight of 65,000 did not possess the regular surface layer. This protein, designated the S protein, specifically reattached to the surface of distilled-water-washed cells in the presence of the divalent calcium, magnesium, strontium, or beryllium cations. All of these cations except beryllium supported reassembly of the S protein into a regular tetragonal array. Although the surface localization of the S protein has been demonstrated, radioiodination of exposed envelope proteins in whole cells did not confirm this. The labeling behavior of the S protein could be explained on the basis of varying accessibilities of different tyrosine residues to iodination. Images PMID:6735982

  2. Anti-HMG-CoA Reductase, Antioxidant, and Anti-Inflammatory Activities of Amaranthus viridis Leaf Extract as a Potential Treatment for Hypercholesterolemia

    PubMed Central

    Salvamani, Shamala; Gunasekaran, Baskaran; Shukor, Mohd Yunus; Shaharuddin, Noor Azmi; Sabullah, Mohd Khalizan

    2016-01-01

    Inflammation and oxidative stress are believed to contribute to the pathology of several chronic diseases including hypercholesterolemia (elevated levels of cholesterol in blood) and atherosclerosis. HMG-CoA reductase inhibitors of plant origin are needed as synthetic drugs, such as statins, which are known to cause adverse effects on the liver and muscles. Amaranthus viridis (A. viridis) has been used from ancient times for its supposedly medically beneficial properties. In the current study, different parts of A. viridis (leaf, stem, and seed) were evaluated for potential anti-HMG-CoA reductase, antioxidant, and anti-inflammatory activities. The putative HMG-CoA reductase inhibitory activity of A. viridis extracts at different concentrations was determined spectrophotometrically by NADPH oxidation, using HMG-CoA as substrate. A. viridis leaf extract revealed the highest HMG-CoA reductase inhibitory effect at about 71%, with noncompetitive inhibition in Lineweaver-Burk plot analysis. The leaf extract showed good inhibition of hydroperoxides, 2,2-diphenyl-1-picrylhydrazyl (DPPH), nitric oxide (NO), and ferric ion radicals in various concentrations. A. viridis leaf extract was proven to be an effective inhibitor of hyaluronidase, lipoxygenase, and xanthine oxidase enzymes. The experimental data suggest that A. viridis leaf extract is a source of potent antioxidant and anti-inflammatory agent and may modulate cholesterol metabolism by inhibition of HMG-CoA reductase. PMID:27051453

  3. Alkane adsorption in Na-exchanged chabazite: the influence of dispersion forces.

    PubMed

    Göltl, Florian; Hafner, Jürgen

    2011-02-14

    The importance of dispersion forces for the correct description of the adsorption of short alkanes in Na-exchanged and purely siliceous chabazite has been investigated at different levels of theory: (i) standard density-functional (DFT) calculations using the Perdew, Burke, and Ernzerhof (PBE) exchange-correlation functional in the generalized gradient approximation, (ii) dispersion corrections based on empirical force fields according to Grimme [J. Computat. Chem. 134, 1463 (2004)- PBE-d], (iii) calculations based on the van der Waals density functional (vdW-DF) proposed by Dion et al. [Phys. Rev. Lett. 92, 246401 (2004)], and (iv) using the random phase approximation (RPA) in combination with the adiabatic-connection fluctuation-dissipation theorem (RPA-ACFDT), using wave-functions calculated at the DFT and Hartree-Fock (HF) levels. A full relaxation of the adsorbate-zeolite complex was performed at the PBE, PBE-d, and vdW-DF levels. RPA and RPA-HF energies were calculated for the optimized configurations. A critical analysis of the results shows that the most accurate description is achieved at the RPA level with HF exchange energies, while both PBE-d and vdW-DF overestimate the strength of the interaction with the acid site. PMID:21322656

  4. Nuclear dynamics in the metastable phase of the solid acid caesium hydrogen sulfate.

    PubMed

    Krzystyniak, Maciej; Drużbicki, Kacper; Fernandez-Alonso, Felix

    2015-12-14

    High-resolution spectroscopic measurements using thermal and epithermal neutrons and first-principles calculations within the framework of density-functional theory are used to investigate the nuclear dynamics of light and heavy species in the metastable phase of caesium hydrogen sulfate. Within the generalised-gradient approximation, extensive calculations show that both 'standard' and 'hard' formulations of the Perdew-Burke-Ernzerhof functional supplemented by Tkatchenko-Scheffler dispersion corrections provide an excellent description of the known structure, underlying vibrational density of states, and nuclear momentum distributions measured at 10 and 300 K. Encouraged by the agreement between experiment and computational predictions, we provide a quantitative appraisal of the quantum contributions to nuclear motions in this solid acid. From this analysis, we find that only the heavier caesium atoms reach the classical limit at room temperature. Contrary to naïve expectation, sulfur exhibits a more pronounced quantum character relative to classical predictions than the lighter oxygen atom. We interpret this hitherto unexplored nuclear quantum effect as arising from the tighter binding environment of this species in this technologically relevant material. PMID:26549527

  5. Characterization and functional properties of the alpha-amylase inhibitor (alpha-AI) from kidney bean (Phaseolus vulgaris) seeds.

    PubMed

    Le Berre-Anton, V; Bompard-Gilles, C; Payan, F; Rougé, P

    1997-11-14

    Alpha-amylase inhibitor (alpha-AI) from kidney bean (Phaseolus vulgaris L. cv Tendergreen) seeds has been purified to homogeneity by heat treatment in acidic medium, ammonium sulphate fractionation, chromatofocusing and gel filtration. Two isoforms, alpha-AI1 and alpha-AI1', of 43 kDa have been isolated which differ from each other by their isoelectric points and neutral sugar contents. The major isoform alpha-AI1 inhibited human and porcine pancreatic alpha-amylases (PPA) but was devoid of activity on alpha-amylases of bacterial or fungal origins. As shown on the Lineweaver-Burk plots, the nature of the inhibition is explained by a mixed non-competitive inhibition mechanism. Alpha-AI1 formed a 1:2 stoichiometric complex with PPA which showed an optimum pH of 4.5 at 30 degrees C. Owing to the low optimum pH found for alpha-AI activity, inhibitor-containing diets such as beans or transgenic plants expressing alpha-AI should be devoid of any harmful effect on human health. PMID:9428656

  6. Triterpenes as uncompetitive inhibitors of α-glucosidase from flowers of Punica granatum L.

    PubMed

    Salah El Dine, Riham; Ma, Qiong; Kandil, Zeinab A; El-Halawany, Ali M

    2014-01-01

    The α-glucosidase and maltase inhibitory effects of Punica granatum L. flowers (PGF) were investigated. The methanol extract (PGFMe), n-hexane extract (PGFH), chloroform extract (PGFC) and the remaining water fraction (PGFW) were assayed for their α-glucosidase and maltase inhibitory effects. PGFW showed potent α-glucosidase inhibition with IC₅₀ of 0.8 μg/mL followed by PGFMe (IC₅₀ of 4.0 μg/mL) then PGFC (IC₅₀ of 5.21 μg/mL) in comparison to acarbose (0.9 μM). Due to its selectivity towards α-glucosidase, PGFC was subjected to bioactivity-guided isolation of its main active constituents. Five known compounds (1-5) were identified as β-sitosterol (1), oleanolic acid (2), ursolic acid (3), p-coumaric acid (4) and apigenin (5). Ursolic and oleanolic acids showed potent α-glucosidase inhibition (IC₅₀ of 39.0 and 35.0 μM, respectively), while they did not show significant maltase inhibition. Kinetic study using the double Lineweaver-Burk plot revealed that ursolic acid uncompetitively inhibited α-glucosidase in comparison with acarbose as a competitive inhibitor. PMID:24956202

  7. First principles LDA + U and GGA + U study of protactinium and protactinium oxides: dependence on the effective U parameter.

    PubMed

    Obodo, K O; Chetty, N

    2013-04-10

    The electronic structure and properties of protactinium and its oxides (PaO and PaO2) have been studied within the framework of the local density approximation (LDA), the Perdew-Burke-Ernzerhof generalized gradient approximation [GGA(PBE)], LDA + U and GGA(PBE) + U implementations of density functional theory. The dependence of selected observables of these materials on the effective U parameter has been investigated in detail. The examined properties include lattice constants, bulk moduli, the effect of charge density distributions, the hybridization of the 5f orbital and the energy of formation for PaO and PaO2. The LDA gives better agreement with experiment for the bulk modulus than the GGA for Pa but the GGA gives better structural properties. We found that PaO is metallic and PaO2 is a Mott-Hubbard insulator. This is consistent with observations for the other actinide oxides. We discover that GGA and LDA incorrectly give metallic behavior for PaO2. The GGA(PBE) + U calculated indirect band gap of 3.48 eV reported for PaO2 is a prediction and should stimulate further studies of this material. PMID:23478314

  8. First principles LDA + U and GGA + U study of protactinium and protactinium oxides: dependence on the effective U parameter

    NASA Astrophysics Data System (ADS)

    Obodo, K. O.; Chetty, N.

    2013-04-01

    The electronic structure and properties of protactinium and its oxides (PaO and PaO2) have been studied within the framework of the local density approximation (LDA), the Perdew-Burke-Ernzerhof generalized gradient approximation [GGA(PBE)], LDA + U and GGA(PBE) + U implementations of density functional theory. The dependence of selected observables of these materials on the effective U parameter has been investigated in detail. The examined properties include lattice constants, bulk moduli, the effect of charge density distributions, the hybridization of the 5f orbital and the energy of formation for PaO and PaO2. The LDA gives better agreement with experiment for the bulk modulus than the GGA for Pa but the GGA gives better structural properties. We found that PaO is metallic and PaO2 is a Mott-Hubbard insulator. This is consistent with observations for the other actinide oxides. We discover that GGA and LDA incorrectly give metallic behavior for PaO2. The GGA(PBE) + U calculated indirect band gap of 3.48 eV reported for PaO2 is a prediction and should stimulate further studies of this material.

  9. Hydrogen incorporation into BN fullerene-like nanostructures: A first-principles study

    NASA Astrophysics Data System (ADS)

    Ganji, M. D.; Abbaszadeh, B.; Ahaz, B.

    2011-10-01

    We performed density functional theory calculations to investigate the possibility of formation of endohedrally H@(BN) n-fullerene ( n: 24, 36, 60) and H@C 60 complexes for potential applications in solid-state quantum-computers. Spin-polarized approach within the generalized gradient approximation with the Perdew-Burke-Ernzerhof functional was used for the total energies and structural relaxation calculations. The calculated binding energies show that H atom being incorporated into B 60N 60 nanocage can form most stable complexes while the B 24N 24 and C 60 nanocages might form unstable complex with positive binding energy. We have also examined the penetration of an H atom into the respective nanocages and the calculated barrier energies indicate that the H atom prefers to penetrate into the B 24N 24 and B 60N 60 nanocages with barrier energy of about 0.47 eV (10.84 kcal/mol). Furthermore the binding characteristic is rationalized by analyzing the electronic structures. Our findings reveal that the B 60N 60 nanocage has fascinating potential application in future solid-state quantum-computers.

  10. First principles calculations of structural, electronic, thermodynamic and optical properties of BAs1 - xPx alloy

    NASA Astrophysics Data System (ADS)

    Drablia, S.; Meradji, H.; Ghemid, S.; Labidi, S.; Bouhafs, B.

    2009-04-01

    First principles calculations have been used to investigate the structural, electronic, thermodynamic and optical properties of boron ternary alloy BAs1 - x Px, using a hybrid full-potential (linear) augmented plane wave plus the local orbitals (APW + lo) method within the density-functional theory (DFT). The Perdew-Burke-Ernzerhof generalized gradient approximation (PBE-GGA) as well as the Engel-Vosko (EV)-GGA are used to calculate the band gap. We investigated the effect of composition on lattice constant, bulk modulus and band gap. Deviations of the lattice constant from Vegard's law and the bulk modulus from linear concentration dependence (LCD) were observed for the alloy. Using the approach of Zunger and co-workers, the microscopic origins of the gap bowing are explained. The thermodynamic stability of the alloy is investigated by calculating the excess enthalpy of mixing ΔHm as well as the phase diagram. The calculated phase diagram showed a broad miscibility gap for the alloy of interest with a high critical temperature. For optical properties, the compositional dependence of the refractive index and the dielectric constant is studied.

  11. Metal/Ceramic Adhesion at the Fe/TiC Interface: II. Work of Adhesion and Force Separation Law

    NASA Astrophysics Data System (ADS)

    Lee, Joo-Hyoung; Shishidou, Tatsuya; Zhao, Yu-Jun; Freeman, A. J.; Olson, G. B.

    2002-03-01

    For high-strength steels with enhanced fracture toughness, the choice of dispersed inclusion phases with the Fe matrix is crucial. For example, it was found that fine particles of Ti carbides and nitrides [Ti(CN)] can provide superior toughness for several steels. (J.E. McVicker, U.S. Patent Number 5, 131, 965, July 21 (1992)) A fundamental understanding of the role of the Ti(CN) particles is, however, not yet given. Here we present first principles calculations of the properties of the Fe/TiC interface with the full-potential linearized augmented plane wave (FLAPW (H.J.F. Jansen and A.J. Freeman, Phys. Rev. B. 30), 561 (1984)) method within the generalized-gradient approximation (GGA (J.P. Perdew, K. Burke and M. Ernzerhof, Phys. Rev. Lett. 77), 3865 (1996)), as modeled with a (Fe)_8/(TiC)4 slab for which a full geometry optimization was performed. A reasonable lattice matching between Fe and TiC was found by determining the lowest elastic-energy cost from the calculated bulk properties of Fe and TiC. Several possible interfacial structure were examined to find the most energetically stable one. Significantly, the calculated charge density shows a strong bonding between Fe and C at the interface, which will be analyzed and discussed.

  12. Structure and stability of SnS2-based single- and multi-wall nanotubes

    NASA Astrophysics Data System (ADS)

    Bandura, Andrei V.; Evarestov, Robert A.

    2015-11-01

    Hybrid density functional method PBE0 which mixes the 75% Perdew-Burke-Ernzerhof and 25% Hartree-Fock exchange functional has been applied for investigation of the electronic and atomic structures of nanotubes obtained by rolling up of hexagonal layers of tin disulfide. Calculations have been performed on the basis of the localized atomic functions by means of the CRYSTAL09 computer code. The calculated strain energy of SnS2 single-wall nanotubes approximately obeys the R- 2 law (R is nanotube radius) of the classical elasticity theory. The SnS2 nanotube electronic band structures yield a semiconducting behavior. Band gap of single-wall nanotubes decreases linearly with R- 1. The dispersion force correction is found to be important for prediction of the multi-wall nanotube stability. The distance and interaction energy between the single-wall components of the double-wall nanotubes are proved to be close to the distance and interaction energy between layers in the bulk crystal. Analysis of the relaxed nanotube shape using the offered method demonstrates a small but noticeable deviation from completely cylindrical cross-section of the external walls in the armchair-like double- and triple-walled nanotubes.

  13. Do quasars evolve over cosmological time scales?

    NASA Astrophysics Data System (ADS)

    Wampler, E. J.; Ponz, D.

    Systematic biases that are redshift dependent can influence the optical discovery of quasars and the evolution laws derived from counts of quasars. New data and their interpretation for quasars brighter than MB = -24 in the Palomar Bright Quasar Survey (BQS) (Schmidt and Green, 1983) are consistent with no evolution. A comparison of BQS quasars with the brightest quasars from the CTIO Schmidt Telescope Survey (Osmer and Smith, 1980) shows that if q(0) is near zero, the comoving density of bright quasars in a Friedmann cosmology is about 15 times higher for the CTIO survey quasars (mean z of about 2.8) than for the BQS quasars (mean z of about 1.8). In this case spectral evolution is also required since the CTIO quasars have stronger CIV 1548 A lines than the BQS quasars of similar luminosity. Alternatively, if q(0) is taken to be near 1, the CTIO survey quasars would then have a lower luminosity than the BQS quasars and these data would be consistent with no evolution. Strong CIV 1548 A lines for the CTIO quasars would then fit the general correlation between absolute quasar luminosity and emission line strength (Wampler, Gaskell, Burke and Baldwin, 1984).

  14. Microstructure and Creep Behavior of Fe-27Al-1Nb Alloys with Added Carbon

    NASA Astrophysics Data System (ADS)

    Dobeš, Ferdinand; Kratochvíl, Petr; Pešička, Josef; Vodičková, Věra

    2015-04-01

    The effect of Nb and C additions on the phase composition, microstructure, and creep resistance of Fe3Al-type alloys is investigated. Two alloys, which contained (at. pct) (i) 27.6 Al, 1.15 Nb and 0.19 C (Fe balance) and (ii) 27.1 Al, 1.11 Nb, and 0.76 C (Fe balance), were studied in a temperature range from 873 K to 1073 K (600 °C to 800 °C). The carbide in both alloys was identified as Nb6C5. The creep data can be rationalized by introducing a threshold stress, below which, the creep rate is negligible. The threshold stress and an effective stress exponent were found simultaneously by a numerical method. Using the obtained values of the threshold stress, the activation energy of creep was determined to be 328 kJ/mol. The effective stress exponent varied from 2.0 to 3.1. A breakdown of power-law behavior was observed at higher stresses. The transition occurred at the normalized creep rate of , which agrees with the rule suggested by Sherby and Burke and the diffusion coefficient D corresponding to the diffusion of Al in Fe-Al.

  15. Limits on the Magnetosphere/Stellar Wind Interactions for the Extrasolar Planet about Tau Bootis

    NASA Astrophysics Data System (ADS)

    Farrell, W. M.; Desch, M. D.; Lazio, T. J.; Bastian, T.; Zarka, P.

    Among the most impressive astronomical discoveries in the past decade are the observations of Jupiter-like planets in orbit around stars similar to our sun (Mayor and Queloz 1995; Marcy 1998). These extrasolar planets are detected primarily from optical signatures of the star's orbital perturbation about the star/planet center of mass. To date, over 80 massive planets have been discovered about sun-like stars, these stars located in the near-vicinity of our own solar system (< 100 pc). By analogy with the sun's gas giant planets, it has been predicted that these extrasolar planets will have electrically-active stellar-wind driven planetary magnetospheres possibly capable of emitting long-wavelength radio emission (Burke 1992; Farrell et al. 1999; Bastian et al. 2000; Zarka et al. 2001) consistent with radiometric Bode's laws known to apply in our solar system. In 1999 and in 2002, the Very Large Array (VLA) surveyed the region near Tau Bootes for long-wavelength radio emission from its extrasolar planet. This planet had been previously predicted to be a good candidate for coherent electron cyclotron radio emission in the 10's of MHz. While no obvious signal was detected at 74 MHz to a sensitivity of <0.12 Janskys, the results can be applied to place upper limits on the stellar winds and planetary magnetic field.

  16. First-principles study of rock-salt AgCl xBr 1-x alloys

    NASA Astrophysics Data System (ADS)

    Amrani, B.; El Haj Hassan, F.; Zoaeter, M.

    2007-06-01

    We present first-principles calculations of the structural, electronic and thermodynamic properties of rock-salt AgCl xBr 1-x alloys by application of the full potential linearized augmented plane wave (FP-LAPW) method. We use both Perdew-Burke-Ernzerhof and Engel-Vosko generalized gradient approximations of the exchange-correlation energy that are based on the optimization of total energy and corresponding potential, respectively. The effect of composition on lattice constants, bulk modulus, cohesive energy, bond ionicity, band gap and effective mass was investigated. These parameters were found to depend nonlinearly on alloy composition x, except the lattice parameter, which follows Vegard's law. The microscopic origins of the gap bowing were explained by using the approach of Zunger and co-workers; we have concluded that the band gap energy bowing was mainly caused by the chemical charge-transfer effect, while the volume deformation and the structural relaxation contribute to the gap bowing parameter at smaller magnitude. On the other hand, the thermodynamic stability of AgCl xBr 1-x was investigated by calculating the excess enthalpy of mixing Δ Hm as well as the phase diagram.

  17. Metal/Ceramic Adhesion at the Fe/TiN Interface: Electronic and Magnetic Structure, and Effect of S Impurities

    NASA Astrophysics Data System (ADS)

    Lee, Joo-Hyoung; Freeman, A. J.; Olson, G. B.

    2004-03-01

    As part of our ongoing effort in steel research to design a new class of materials with advanced fracture toughness and strength, we performed first-principles calculations on the Fe matrix/TiN fine particle interface with the all-electron full-potential linearized augmented plane wave (FLAPW) method for film geometry(Wimmer, Krakauer, Weinert, and Freeman, Phys. Rev. B, 24), 864 (1981) within the generalized-gradient approximation (GGA(J. Perdew, K. Burke, and M. Ernzerhof, Phys. Rev. Lett. 77), 3865 (1996)), and compared the results with those found previously for Fe/TiC(T. Shishidou,Joo-Hyoung Lee, Yu-Jun Zhao, A. J. Freeman, and G. B. Olson, unpublished). The work of adhesion (3.82 J/m^2 for Fe/TiC, and 3.79 J/m^2 for Fe/TiN) and their calculated force separation laws are very close to each other, but the induced Ti magnetic moment at the interface shows a large difference (-0.02 μ_B for Fe/TiC, and -0.19 μ_B for Fe/TiN). In order to investigate impurity effects, 25% of S atoms were inserted at the interface; results of calculations (now in progress) on the effects of S will be analyzed and discussed.

  18. Cellular automata simulation of grain growth in three dimensions based on the lowest-energy principle

    NASA Astrophysics Data System (ADS)

    Ding, H. L.; He, Y. Z.; Liu, L. F.; Ding, W. J.

    2006-08-01

    The microstructure and morphology evolution of grain growth were studied by 3D simulation using the cellular automata (CA) model based on the lowest-energy principle. In the present CA model, the transition of cells during the grain growth has a typical physical meaning due to the application of the lowest-energy principle. The results show that the kinetics of grain growth follows Burke equation with the growth exponent as 2. The average number of grain faces is 13.6 and the highest frequency of grain faces is 10 faces. The grain size distribution follows Weibull function. The relationship between the number of faces of a grain and the average number of faces of its adjacent grains follows the Aboav-Weaire law. There is a correlation between the topologies of the simulated 2D and 3D grain growth. The average number of sides per face for all grains is 5.65 and the average number of sides per face is about equal to 6 when the grain aces is larger than 35.

  19. Potentially superhard hcp Cr N2 compound studied at high pressure

    NASA Astrophysics Data System (ADS)

    Zhao, Zhonglong; Bao, Kuo; Tian, Fubo; Duan, Defang; Liu, Bingbing; Cui, Tian

    2016-06-01

    Motivated by recent developments in nitrogen-rich transition-metal nitrides, the stability of chromium mononitride (CrN) and the possible formation of chromium dinitride (Cr N2 ) are studied using density functional theory (with the Perdew-Burke-Ernzerhof functional within the generalized gradient approximation, local density approximation plus U, and Heyd-Scuseria-Ernzerhof hybrid exchange-correlation potentials), ab initio evolutionary algorithm, as well as ab initio molecular dynamics. It is found that low-temperature orthorhombic CrN will transform into a hexagonal-close-packed (hcp) structure at above 108 GPa. Two hcp Cr N2 , constructed by replacing the interstitial nitrogen in hcp CrN with nitrogen-nitrogen units, are predicted to be stable at above 7 GPa due to the physics of precompression. We show that the Cr-N bond length in hcp Cr N2 at 0 GPa is comparable to that of the CrN prototype at more than 45 GPa, and the electrons have been transformed from itinerant to localized, which results in unique metal-insulator transitions and a high hardness of 46 GPa. These results, therefore, provide crucial insights for designing covalence-dominated transition-metal compounds.

  20. New Whitening Constituents from Taiwan-Native Pyracantha koidzumii: Structures and Tyrosinase Inhibitory Analysis in Human Epidermal Melanocytes

    PubMed Central

    Lin, Rong-Dih; Chen, Mei-Chuan; Liu, Yan-Ling; Lin, Yi-Tzu; Lu, Mei-Kuang; Hsu, Feng-Lin; Lee, Mei-Hsien

    2015-01-01

    Nontoxic natural products useful in skin care cosmetics are of considerable interest. Tyrosinase is a rate-limiting enzyme for which its inhibitor is useful in developing whitening cosmetics. Pyracantha koidzumii (Hayata) Rehder is an endemic species in Taiwan that exhibits tyrosinase-inhibitory activity. To find new active natural compounds from P. koidzumii, we performed bioguided isolation and studied the related activity in human epidermal melanocytes. In total, 13 compounds were identified from P. koidzumii in the present study, including two new compounds, 3,6-dihydroxy-2,4-dimethoxy-dibenzofuran (9) and 3,4-dihydroxy-5-methoxybiphenyl-2ʹ-O-β-d-glucopyranoside (13), as well as 11 known compounds. The new compound 13 exhibited maximum potency in inhibiting cellular tyrosinase activity, the protein expression of cellular tyrosinase and tyrosinase-related protein-2, as well as the mRNA expression of Paired box 3 and microphthalmia-associated transcription factor in a concentration-dependent manner. In the enzyme kinetic assay, the new compound 13 acted as an uncompetitive mixed-type inhibitor against the substrate l-3,4-dihydroxyphenylalanine and had a Km value against this substrate of 0.262 mM, as calculated using the Lineweaver–Burk plots. Taken together, our findings show compound 13 exhibits tyrosinase inhibition in human melanocytes and compound 13 may be a potential candidate for use in cosmetics. PMID:26633381

  1. Analytic coupled channel calculation of ultracold three-body collision rates

    NASA Astrophysics Data System (ADS)

    Meyer, Edmund; Esry, B. D.

    2012-06-01

    We analyze three-body recombination for positive two-body s-wave scattering lengths. Using the adiabatic hyperspherical representation as a starting point, we introduce coupling between the three-body continuum and the weakly bound diatom plus atom channel in the vicinity of R˜a---the location where rigorous calculations have shown the coupling to peak [1]. In order to model loss to deeply bound diatom channels, we introduce a complex short-range K-matrix. Analytic expressions for the loss rates are derived and we recover the behavior found previously [2], including the overall a^4 scaling for identical bosons as well as the log-periodic modulation due to Efimov physics. Our formulation permits straightforward extensions to other symmetries and higher energies. [4pt] [1] J. P. D'Incao and B. D. Esry, Phys. Rev. A 72, 032710 (2005) [2] B. D. Esry, C. H. Greene, and J. P. Burke, Jr., Phys. Rev. Lett. 83, 1751 (1999).

  2. Electronic and magnetic properties of small rhodium clusters

    SciTech Connect

    Soon, Yee Yeen; Yoon, Tiem Leong; Lim, Thong Leng

    2015-04-24

    We report a theoretical study of the electronic and magnetic properties of rhodium-atomic clusters. The lowest energy structures at the semi-empirical level of rhodium clusters are first obtained from a novel global-minimum search algorithm, known as PTMBHGA, where Gupta potential is used to describe the atomic interaction among the rhodium atoms. The structures are then re-optimized at the density functional theory (DFT) level with exchange-correlation energy approximated by Perdew-Burke-Ernzerhof generalized gradient approximation. For the purpose of calculating the magnetic moment of a given cluster, we calculate the optimized structure as a function of the spin multiplicity within the DFT framework. The resultant magnetic moments with the lowest energies so obtained allow us to work out the magnetic moment as a function of cluster size. Rhodium atomic clusters are found to display a unique variation in the magnetic moment as the cluster size varies. However, Rh{sub 4} and Rh{sub 6} are found to be nonmagnetic. Electronic structures of the magnetic ground-state structures are also investigated within the DFT framework. The results are compared against those based on different theoretical approaches available in the literature.

  3. Glutaraldehyde activated eggshell membrane for immobilization of tyrosinase from Amorphophallus companulatus: application in construction of electrochemical biosensor for dopamine.

    PubMed

    Tembe, Sanket; Kubal, B S; Karve, Meena; D'Souza, S F

    2008-04-01

    Tyrosinase from a plant source Amorphophallus companulatus was immobilized on eggshell membrane using glutaraldehyde. Among the three different approaches used for immobilization, activation of eggshell membrane by glutaraldehyde followed by enzyme adsorption on activated support could stabilize the enzyme tyrosinase and was found to be effective. K(m) and V(max) values for dopamine hydrochloride calculated from Lineweaver-Burk plot were 0.67 mM and 0.08 mM min(-1), respectively. Studies on effect of pH showed retention of more than 90% activity over a pH range 5.0-6.5. Membrane bound enzyme exhibited consistent activity in the temperature range 20-45 degrees C. Shelf life of immobilized tyrosinase system was found to be more than 6 months when stored in phosphate buffer at 4 degrees C. An electrochemical biosensor for dopamine was developed by mounting the tyrosinase immobilized eggshell membrane on the surface of glassy carbon electrode. Dopamine concentrations were determined by the direct reduction of biocatalytically liberated quinone species at -0.19 V versus Ag/AgCl (3M KCl). Linearity was observed within the range of 50-250 microM with a detection limit of 25 microM. PMID:18358868

  4. The influence of a 21 kDa Kunitz-type trypsin inhibitor from nonhost madras thorn, Pithecellobium dulce, seeds on H. armigera (Hübner) (Lepidoptera: Noctuidae).

    PubMed

    Pandey, Prabhash K; Singh, Dushyant; Jamal, Farrukh

    2015-05-01

    A trypsin inhibitor purified from the seeds of the Manila tamarind, Pithecellobium dulce (PDTI), was studied for its effects on growth parameters and developmental stages of Helicoverpa armigera. PDTI exhibited inhibitory activity against bovine trypsin (∼86%; ∼1.33 ug/ml IC50). The inhibitory activity of PDTI was unaltered over a wide range of temperature, pH, and in the presence of dithiothreitol. Larval midgut proteases were unable to digest PDTI for up to 12 h of incubation. Dixon and Lineweaver-Burk double reciprocal plots analysis revealed a competitive inhibition mechanism and a Ki of ∼3.9 × 10(-8) M. Lethal dose (0.50% w/w) and dosage for weight reduction by 50% (0.25% w/w) were determined. PDTI showed a dose-dependent effect on mean larval weight and a series of nutritional disturbances. In artificial diet at 0.25% w/w PDTI, the efficiency of conversion of ingested food, of digested food, relative growth rate, and growth index declined, whereas approximate digestibility, relative consumption rate, metabolic cost, consumption index, and total developmental period were increased in larvae. This is the first report of antifeedant and antimetabolic activities of PDTI on midgut proteases of H. armigera. PMID:25580830

  5. Test of a nonempirical density functional for short-range van der Waals interaction in rare-gas dimers

    NASA Astrophysics Data System (ADS)

    Tao, Jianmin

    2005-03-01

    It is known that the nonempirical generalized gradient approximation (GGA) of Perdew, Burke, and Ernzerhof (PBE) provides a much more realistic description of the short-range part of the van der Waals (vdW) interaction than does the local spin density (LSD) approximation. In the present work, the ability of the higher-level nonempirical meta-GGA of Tao, Perdew, Staroverov, and Scuseria (TPSS) [Phys. Rev. Lett. 91, 146401 (2003)] to describe vdW interaction is tested self-consistently in rare-gas dimers with Z <=36. The one-parameter hybrid version (TPSSh) of the TPSS exchange-correlation functional is also included in this test. Calculations show that both TPSS and TPSSh functionals correctly yield vdW bonds in these dimers and significantly improve the prediction of bond lengths and binding energies over LSD. The rather close agreement of TPSS with PBE for these dimers confirms a principle of the TPSS construction: preservation of the PBE large-gradient behavior. Compared with the PBE GGA, TPSS and TPSSh yield a slightly weaker binding. The typically too-long bond lengths and too-small binding energies of TPSS meta-GGA suggest the need for some long-range vdW interaction correction which is discussed.

  6. Influence of Nitrogen Content on Thermal Stability and Grain Growth Kinetics of Cryomilled Al Nanocomposites

    NASA Astrophysics Data System (ADS)

    Hashemi-Sadraei, L.; Mousavi, S. E.; Vogt, R.; Li, Y.; Zhang, Z.; Lavernia, E. J.; Schoenung, J. M.

    2012-02-01

    Nanocomposite powders of Al 5083/B4C were produced via cryogenic milling (cryomilling) of boron carbide (B4C) particles in Al 5083 matrix. The effect of milling time (up to 24 hours), and consequential nitrogen content, on grain growth in the nanocrystalline Al 5083 matrix was investigated. Thermal stability was studied at temperatures as high as ~0.96 T m and annealing times of up to 24 hours. Average grain sizes increased with time and temperature and tended to stabilize after longer annealing times, regardless of nitrogen content. Higher thermal stability was observed in samples with higher nitrogen content, with the average grain size remaining in the range of 30 nm, even after exposure to the most extreme annealing conditions. This behavior was attributed to the retarding effect that nitrides have on grain growth, as a result of pinning grain boundaries. Kinetic studies based on the Burke equation showed two thermally activated grain growth regimes—a low-temperature regime with an activation energy of 15 kJ/mol and a high-temperature regime with an activation energy of 58 kJ/mol.

  7. Ouabain inhibits placental sFlt1 production by repressing HSP27-dependent HIF-1α pathway

    PubMed Central

    Rana, Sarosh; Rajakumar, Augustine; Geahchan, Carl; Salahuddin, Saira; Cerdeira, Ana Sofia; Burke, Suzanne D.; George, Eric M.; Granger, Joey P.; Karumanchi, S. Ananth

    2014-01-01

    Up-regulation of placental soluble fms-like tyrosine kinase 1 (sFlt1) contributes to the pathogenesis of preeclampsia. To evaluate novel upstream pathways that regulate placental sFlt1 production, we screened a library of natural compounds (n=502) in human placental cell lines. Here, we report 3 compounds in the cardiac glycoside family, ouabain, gitoxigenin, and digitoxin, that inhibit placental sFlt1 production at nanomolar concentrations in vitro. We further characterized ouabain and demonstrated that it inhibits sFlt1 mRNA and protein expression in human placental cytotrophoblasts and explant cultures in a dose- and time-dependent manner. Ouabain down-regulated sFlt1 production by inhibiting hypoxia-inducible factor 1 (HIF-1α) protein expression in the placenta. Furthermore, we found that phosphorylation of heat-shock protein 27 (HSP27) was necessary for ouabain to inhibit HIF-1α translation. In a rat model of pregnancy-induced hypertension, ouabain reduced mean arterial pressure and enhanced placental HSP27 phosphorylation without any adverse effects on pups. Further studies are needed to explore the usefulness of targeting HIF-1α/HSP27 pathway in preeclampsia.—Rana, S., Rajakumar, A., Geahchan, C., Salahuddin, S., Cerdeira, A. S., Burke, S. D., George, E. M., Granger, J. P., Karumanchi, S. A. Ouabain inhibits placental sFlt1 production by repressing HSP27-dependent HIF-1α pathway. PMID:24970393

  8. Technical Review of Retrieval and Closure Plans for the INEEL INTEC Tank Farm Facility

    SciTech Connect

    Bamberger, Judith A; Burks, Barry L; Quigley, Keith D; Falter, Diedre D

    2001-09-28

    The purpose of this report is to document the conclusions of a technical review of retrieval and closure plans for the Idaho National Energy and Environmental Laboratory (INEEL) Idaho Nuclear Technology and Engineering Center (INTEC) Tank Farm Facility. In addition to reviewing retrieval and closure plans for these tanks, the review process served as an information exchange mechanism so that staff in the INEEL High Level Waste (HLW) Program could become more familiar with retrieval and closure approaches that have been completed or are planned for underground storage tanks at the Oak Ridge National Laboratory (ORNL) and Hanford sites. This review focused not only on evaluation of the technical feasibility and appropriateness of the approach selected by INEEL but also on technology gaps that could be addressed through utilization of technologies or performance data available at other DOE sites and in the private sector. The reviewers, Judith Bamberger of Pacific Northwest National Laboratory (PNNL) and Dr. Barry Burks of The Providence Group Applied Technology, have extensive experience in the development and application of tank waste retrieval technologies for nuclear waste remediation.

  9. Astronomy and space science from the moon: Panel discussion and perspectives

    NASA Astrophysics Data System (ADS)

    Foing, B. H.

    1994-06-01

    The COSPAR Symposium on 'Astronomy and Space Science from the Moon', held at the COSPAR/IAF World Space Congress in Washington (on 31 August-3 September 1992), ended with a session on 'Scenarios for lunar bases and observatories'. A panel discussion was organized to address specific topics: Precursor astronomy missions; Launch, landing and transportation systems, technologies; Site selection and emplacement, resource utilization, architectural considerations; Link with space stations, and Mars exploration programs; Human aspects, performance, protection, operations and activities; Protection of the lunar environment; and Biospheres on the Moon. The panel discussion, coordinated by B. H. Foing (F) included in particular contributions from Drs. Matogawa (Japan), R. M. Bonnet (ESA), H. Balsiger (CH and ESA representative), P. Bochsler (CH), S. Volonte (ESA), W. Mendell (NASA), W. Sadeh (USA), R. Manka (USA), B. Burke (USA), M. Rougeron (CNES), V. Bluem (Germany) and from the general participants. We give here a summary of these discussions. We also include additional information for assessing the perspectives for Lunar based activities after the COSPAR symposium.

  10. Purification and characterization of glutathione S-transferase from turkey liver and inhibition effects of some metal ions on enzyme activity.

    PubMed

    Akkemik, Ebru; Taser, Pinar; Bayindir, Aysegul; Budak, Harun; Ciftci, Mehmet

    2012-11-01

    The glutathione S-transferases (EC 2.5.1.18) were purified and characterized from turkey liver for the first time. The enzyme was purified 252.7-fold with a yield of 45%, with a specific activity of 164.31 U/mg from turkey liver. The purity of the enzyme was determined by SDS-PAGE and showed two bands nearly 26 kDa and 24 kDa on the gel. The native molecular mass of the enzyme was found to be approximately 53 kDa by Sephadex G-100 gel filtration chromatography. Optimal pH, stable pH, optimal temperature, optimum ionic strength, K(m) and V(max) values for GSH and CDNB were also determined for the enzyme as 7.3, 8.5, 50 °C, 600 mM, 0.154 mM, 0.380 mM, 1.803 EU/ml, and 2.125 EU/ml, respectively. Additionally, inhibitory effects of metal ions (Cu(2+), Hg(2+), Fe(2+), Zn(2+), Ag(+), Mg(2+), Ni(2+), and Mn(2+)) were examined the enzyme's activity in vitro by performing Lineweaver-Burk graphs and plotting activity% vs., respectively. PMID:22989768

  11. Chronic sorrow and coping in families of children with epilepsy.

    PubMed

    Hobdell, Elizabeth F; Grant, Mitzie L; Valencia, Ignacio; Mare, Jane; Kothare, Sanjeev V; Legido, Agustin; Khurana, Divya S

    2007-04-01

    Epilepsy, a common problem in child neurology, affects the entire family. There is a potential for such psychosocial consequences as parental chronic sorrow and alterations in coping. In this study, 67 parents completed brief questionnaires about their sorrow and coping styles. Results demonstrated chronic sorrow as measured by the Adapted Burke Questionnaire (10.45 +/- 7.9). Interestingly, the total score was not significantly different between parents of children with refractory and nonrefractory epilepsy or parents of children with comorbid or without comorbid conditions. Selection of the individual item disbelief, however, was significantly increased in parents of children with nonrefractory epilepsy, and selection of the item anger was significantly increased in parents of children with comorbid conditions. Parental coping styles were similar to those reported in the normative data for the instrument used, the Coping Health Inventory for Parents (CHIP). The correlation between chronic sorrow and coping was significant between the grief component of sorrow and Coping Pattern II of the CHIP. Implications for practice include earlier identification of parental feelings of sorrow and coping styles, which may contribute to a positive outcome. PMID:17477221

  12. Transcendence, ethics, and Mobil Oil: a rhetorical investigation

    SciTech Connect

    Williamson, L.A.

    1982-01-01

    Since 1970 the Mobil Oil Corporation has been widely recognized as the self-appointed champion of corporate America's right to advocate. Corporate advocacy, as distinguished from other forms of external corporate communication, is concerned with the modification of corporate images and those social and political issues directly linked to the well-being of the corporation. Kenneth Burke's theory of transcendence serves as the central critical referent in the critique of Mobil's advocacy. By evoking elaborate transcendent frames of reference, Mobil seeks to identify its actions with higher syntheses that allow them to transcend the guilt produced by identifications with lesser orders. Mobil evokes two ultimate frames which are recurrent in their transcendent identifications: American energy independence and freedom of expression. In the latter part of this investigation, Sidney Hook's ethics of controversy was offered as an ethical referent. Two levels of analysis were conducted: first, three major types of arguments against Mobil's advocacy were evaluated; second, Mobil's discourse was evaluated. The conclusion was reached that Mobil's advocacy is largely an ethical form of American democratic discourse. In the final section of this investigation, the heuristic values of this critique were discussed.

  13. Electrochemical Urea Biosensor Based on Sol-gel Derived Nanostructured Cerium Oxide

    NASA Astrophysics Data System (ADS)

    Ansari, Anees A.; Azahar, Md; Malhotra, B. D.

    2012-04-01

    Urease (Urs) and glutamate dehydrogenase (GLDH) have been co-immobilized onto a nanostructured-cerium oxide (Nano-CeO2) film deposited onto a indium-tin-oxide (ITO) coated glass substrate by dip-coating via sol-gel process for urea detection. This nanostructured film has characterized using X-ray diffraction (XRD), Fourier transform infrared (FTIR), Scanning electron microscope (SEM) and electrochemical techniques, respectively. The particle size of the Nano-CeO2 film has been found to be 23 nm. Electrochemcial response (CV) studies show that Ur-GLDH/Nano-CeO2/ITO bioelectrode is found to be sensitive in the 10-80 mg/dL urea concentration range and can detect urea concentration upto 0.1 mg/dL level. The value of Michaelis-Menten constant (Km) estimated using Lineweaver-Burke plot found as 6.09 mg/dL indicates enhancement in the affinity and/or activity of enzyme attached to their nanobiocomposite. This bioelectrode retained 95% of enzyme activity after 6 months at 4°C.

  14. Ice phases under ambient and high pressure: Insights from density functional theory

    NASA Astrophysics Data System (ADS)

    Fang, Yuan; Xiao, Bing; Tao, Jianmin; Sun, Jianwei; Perdew, John P.

    2013-06-01

    Water is common and plays a crucial role in biological, chemical, and physical processes, but its crystalline or ice state has a complicated structure. In this work, we study the lattice mismatch challenge for ice nucleation on silver iodide, the sublimation energy for different ice phases, and the structural phase-transition pressures of ice, with various density functionals. Our calculations show that the recently developed meta-generalized gradient approximation made simple (MGGA_MS) yields a lattice mismatch (3%) of hexagonal ice (ice Ih) with β-AgI in good agreement with experiment (2%), significantly better than the Perdew-Burke-Ernzerhof (PBE) GGA mismatch (6%). MGGA_MS is a computationally efficient semilocal functional that incorporates intermediate-range van der Waals (vdW) interaction, which, overall, performs well for ice and may be expected to improve upon PBE for liquid water. While MGGA_MS predicts the most realistic volumes and volume changes in the phase transitions of ice Ih to trigonal ice (ice II) and tetragonal ice (ice VIII), a more accurate description of some other properties of the higher-pressure phases (ice II and ice VIII) is provided by some functionals that include long-range vdW corrections (e.g., revised Tao-Perdew-Staroverov-Scuseria+vdW for sublimation energy and optB88-vdW for transition pressure).

  15. Strain-Induced Pseudo--Magnetic Fields in Graphene: MegaGauss in Nanobubbles

    NASA Astrophysics Data System (ADS)

    Levy, Niv

    2011-03-01

    Recent theoretical proposals suggest that strain can be used to modify graphene electronic states through the creation of a pseudo--magnetic field. This effect is unique to graphene because of its massless Dirac fermion-like band structure and particular lattice symmetry (C3v). Scanning tunneling microscopy shows that graphene grown on a platinum (111) surface forms nanobubbles, which are highly strained due to thermal expansion mismatch between the film and the substrate. We find that scanning tunneling spectroscopy measurements of these nanobubbles exhibit Landau levels that form in the presence of strain-induced pseudo--magnetic fields greater than 300 Tesla. This demonstration of enormous pseudo--magnetic fields opens the door to both the study of charge carriers in previously inaccessible high magnetic field regimes and deliberate mechanical control over electronic structure in graphene or so-called ``strain engineering''. In collaboration with S. A. Burke ,2 , K. L. Meaker 2 , M. Panlasigui 2 , A. Zettl 2,3 , F. Guinea 4 , A. H. Castro Neto 5 and M. F. Crommie 2,3 . 1. Present address: Department of Physics and Astronomy and Department of Chemistry, University of British Columbia, Vancouver, BC V6T 121, Canada. 2. Department of Physics, University of California, Berkeley, CA 94720, USA. 3. Materials Science Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA. 4. Instituto de Ciencia de Materiales de Madrid (CSIC), Madrid 28049, Spain. 5. Department of Physics, Boston University, Boston, MA 02215, USA.

  16. On the bonding nature of electron states for the Fe-Mo double perovskite

    SciTech Connect

    Carvajal, E.; Cruz-Irisson, M.; Oviedo-Roa, R.; Navarro, O.

    2014-05-15

    The electronic transport as well as the effect of an external magnetic field has been investigated on manganese-based materials, spinels and perovskites. Potential applications of double perovskites go from magnetic sensors to electrodes in solid-oxide fuel cells; besides the practical interests, it is known that small changes in composition modify radically the physical properties of double perovskites. We have studied the Sr{sub 2}FeMoO{sub 6} double perovskite compound (SFMO) using first-principles density functional theory. The calculations were done within the generalized gradient approximation (GGA) scheme with the Perdew-Burke-Ernzerhof (PBE) functional. We have made a detailed analysis of each electronic state and the charge density maps around the Fermi level. For the electronic properties of SFMO it was used a primitive cell, for which we found the characteristic half-metallic behavior density of states composed by e{sub g} and t{sub 2g} electrons from Fe and Mo atoms. Those peaks were tagged as bonding or antibonding around the Fermi level at both, valence and conduction bands.

  17. Chemical and Genetic Comparative Analysis of Gentiana crassicaulis and Gentiana macrophylla.

    PubMed

    Wang, Yaping; Ahmad, Bashir; Duan, Baozhong; Zeng, Rui; Huang, Linfang

    2016-06-01

    Gentiana crassicaulis Duthie ex Burk. and Gentiana macrophylla Pall. are two main sources of Radix Gentianae Macrophyllae (Qinjiao) available in markets, which has a wide range of anti-inflammatory effects and has been extensively used for fighting rheumatoid arthritis. However, they vary in terms of chemical compositions, pharmacological activities, and biomass. In this study, a combined chemical and genetic (HPLC and DNA barcoding) approach was used to compare these two plants. Four predominant bioactive compounds, namely, gentiopicroside, loganic acid, swertiamarin, and sweroside, were used to assess the chemical variations. Based on chemical variations, 15 samples were clustered into two groups through PCA analyses. DNA barcoding utilizing the variable nuclear ITS2 regions were sequenced, aligned, and compared. Together with 61 sequences collected from GenBank, 76 batches of Qinjiao were clustered in two groups according to species origin. The genetic relationships indicated by the ITS2-based NJ tree were consistent with the chemical variations. Thus, the chemical profiles determined by HPLC and DNA profiles obtained from ITS2 region could be applied for the quality control of Qinjiao. PMID:27144464

  18. A novel glucose oxidase biosensor based on poly([2,2';5',2″]-terthiophene-3'-carbaldehyde) modified electrode.

    PubMed

    Guler, Muhammet; Turkoglu, Vedat; Kivrak, Arif

    2015-08-01

    In the study, the electrochemical behavior of glucose oxidase (GOx) immobilized on poly([2,2';5',2″]-terthiophene-3'-carbaldehyde) (poly(TTP)) modified glassy carbon electrode (GCE) was investigated. The biosensor (poly(TTP)/GOx/GCE) showed a pair of redox peaks in 0.1 M phosphate buffer (pH 7.4) solution in the absence of oxygen the co-substrate of GOx. In here, Poly(TTP)/GOx/GCE biosensor acts as the co-substrate instead of oxygen. Upon the addition of glucose, the reduction and oxidation peak currents increased until the active site of GOx was fully saturated with glucose. The apparent m was estimated 26.13 mM from Lineweaver-Burk graph. The biosensor displayed a good stability and bioactivity. The biosensor showed a high sensitivity (56.1 nA/mM), a linear range (from 0.5 to 20.15 mM), and a good reproducibility with 3.6% of relative standard deviation. In addition, the interference currents of glycin, ascorbic acid, histidine, uric acid, dopamine, arginine, and fructose on GOx biosensor were investigated. All that substances exhibited an interference current under 10%. It was not shown a marked difference between GOx biosensor and spectrophotometric measurement of glucose in serum examples. UV-visible spectroscopy and scanning electron microscopy (SEM) experiments of the biosensor were also performed. PMID:25934105

  19. Screened hybrid and self-consistent GW calculations of cadmium/magnesium indium sulfide materials

    NASA Astrophysics Data System (ADS)

    Lucero, Melissa J.; Aguilera, Irene; Diaconu, Cristian V.; Palacios, Pablo; Wahnón, Perla; Scuseria, Gustavo E.

    2011-05-01

    The cadmium and magnesium indium sulfides are medium-gap semiconductors demonstrating a propensity to form intermediate band materials when doped with transition metals. The inherent structural diversity exhibited by M+2In2S4 thiospinels and related AB2X4 compounds often precludes definitive experimental determination of the band-gap width and type of transition. Employing a series of traditional semilocal functionals (e.g., the local spin density approximation; the Perdew, Burke, and Enzerhof functional; and the Tao, Perdew, Staroverov, and Scuseria functional) the screened hybrid of Heyd, Scuseria, and Ernzerhof (HSE), band gaps, projected densities of states, and band structures are calculated for the normal, full inverse, and intermediate configurations of [Cd/Mg]8In16S32. Band structures and band gaps are also obtained via self-consistent many-body methods, using the static Coulomb-hole and screened exchange approximation to GW as a starting point for perturbative G0W0 calculations. Comparison to experiment indicates that HSE provides an accurate, computationally efficient, and relatively rapid means for predicting band-gap properties in spinel-type photovoltaic materials.

  20. Inhibitory effect of salvianolate on human cytochrome P450 3A4 in vitro involving a noncompetitive manner

    PubMed Central

    Qin, Chong-Zhen; Ren, Xian; Zhou, Hong-Hao; Mao, Xiao-Yuan; Liu, Zhao-Qian

    2015-01-01

    Salvianolic acid B (Sal B), which is purified from Danshen, is a popular herb extract. Sal B has anti-oxidative, anti-inflammatory, anti-hypoxic, anti-arteriosclerotic and anti-apoptotic properties. This substance can also ameliorate brain injury or neurodegenerative diseases. The listed drug Salvianolate, which contains a substantial amount of Sal B, has been used for the treatment of coronary heart disease. Our present work aimed to evaluate the inhibitory effect of salvianolate on seven cytochrome P450 isoforms (CYP450), namely, CYP1A2, CYP2A6, CYP2E1, CYP2C9, CYP2C19, CYP2D6 and CYP3A4, in human liver microsomes (HLMs) and recombinant enzymes through high-performance liquid chromatography (HPLC) assay. Salvianolate have a potent inhibitory effect on CYP3A4 activity with IC50 values of 1.438 (HLMs) and 3.582 (recombinant cDNA-expressed CYP3A4) mg/L, respectively. Salvianolate strongly dose, but not time-dependently decreased CYP3A4 activity in HLMs. The typical Lineweaver-Burk plots showed that Salvianolate inhibited CYP3A4 activity noncompetitively, with a Ki value of 2.27 mg/L in HLMs. Other CYP450 isoforms are not markedly affected by Salvianolate. These findings indicate that salvianolate may be involved in potential drug interactions when co-administrated with CYP3A4 substrates. PMID:26629047

  1. Influence of a Simple Heat Loss Profile on a Pure Diffusion Flame

    NASA Technical Reports Server (NTRS)

    Ray, Anjan; Wichman, Indrek S.

    1996-01-01

    The presence of soot on the fuel side of a diffusion flame results in significant radiative heat losses. The influence of a fuel side heat loss zone on a pure diffusion flame established between a fuel and an oxidizer wall is investigated by assuming a hypothetical sech(sup 2) heat loss profile. The intensity and width of the loss zone are parametrically varied. The loss zone is placed at different distances from the Burke-Schumann flame location. The migration of the temperature and reactivity peaks are examined for a variety of situations. For certain cases the reaction zone breaks through the loss zone and relocates itself on the fuel side of the loss zone. In all cases the temperature and reactivity peaks move toward the fuel side with increased heat losses. The flame structure reveals that the primary balance for the energy equation is between the reaction term and the diffusion term. Extinction plots are generated for a variety of situations. The heat transfer from the flame to the walls and the radiative fraction is also investigated, and an analytical correlation formula, derived in a previous study, is shown to produce excellent predictions of our numerical results when an O(l) numerical multiplicative constant is employed.

  2. Dr Thomas Beddoes: chemistry, medicine, and the perils of democracy.

    PubMed

    Levere, Trevor H

    2009-09-20

    Beddoes lectured on chemistry at Oxford in the years that included the French Revolution, the Terror, and the outbreak of war with France, as well as the success in France of the chemical revolution. The very public dispute between Edmund Burke and Joseph Priestley meant that the latter's study of different kinds of air was politically tainted. Beddoes's democratic beliefs and his support for the new chemistry of Lavoisier meant that as chemist and physician he had to deal with complaints that he was potentially seditious and pro-French. His medical theories, allied to pneumatic chemistry and building on the work of Priestley, were accordingly suspect. In spite of that, he became the physician and friend to several members of the Lunar Society of Birmingham and to members of their family, and they in return became his patrons. His collaboration with James Watt was crucial for his development of pneumatic medicine. The full extent of Lunar patronage, and especially that of James Keir and Thomas Wedgwood, has hitherto not been recognized, but it was the concealed scale of that patronage that made possible the execution of Beddoes's ambitious programme of treatment and research. PMID:20027744

  3. Framework for Understanding LENR Processes, Using Ordinary Condensed Matter Physics

    NASA Astrophysics Data System (ADS)

    Chubb, Scott

    2005-03-01

    As I have emphasizedootnotetextS.R. Chubb, Proc. ICCF10 (in press). Also, http://www.lenr-canr.org/acrobat/ChubbSRnutsandbol.pdf http://www.lenr-canr.org/acrobat/ChubbSRnutsandbol.pdf, S.R. Chubb, Trans. Amer. Nuc. Soc. 88 , 618 (2003)., in discussions of Low Energy Nuclear Reactions(LENRs), mainstream many-body physics ideas have been largely ignored. A key point is that in condensed matter, delocalized, wave-like effects can allow large amounts of momentum to be transferred instantly to distant locations, without any particular particle (or particles) acquiring high velocity through a Broken Gauge Symmetry. Explicit features in the electronic structure explain how this can occur^1 in finite size PdD crystals, with real boundaries. The essential physics^1 can be related to standard many-body techniquesootnotetextBurke,P.G. and K.A. Berrington, Atomic and Molecular Processes:an R matrix Approach (Bristol: IOP Publishing, 1993).. In the paper, I examine this relationship, the relationship of the theory^1 to other LENR theories, and the importance of certain features (for example, boundaries^1) that are not included in the other LENR theories.

  4. Effects of some analgesic anaesthetic drugs on human erythrocyte glutathione reductase: an in vitro study.

    PubMed

    Senturk, Murat; Irfan Kufrevioglu, O; Ciftci, Mehmet

    2009-04-01

    Inhibitory effects of some analgesic and anaesthetic drugs on human erythrocyte glutathione reductase were investigated. For this purpose, human erythrocyte glutathione reductase was initially purified 2139-fold in a yield of 29% by using 2', 5'-ADP Sepharose 4B affinity gel and Sephadex G-200 gel filtration chromatography. SDS polyacrylamide gel electrophoresis confirmed the purity of the enzyme by sharing a single band. A constant temperature (+4 degrees C) was maintained during the purification process. Diclofenac sodium, ketoprofen, lornoxicam, tenoxicam, etomidate, morphine and propofol exhibited inhibitory effects on the enzyme in vitro using the Beutler assay method. K(i) constants and IC(50) values for drugs were determined from Lineweaver-Burk graphs and plotting activity % versus [I] graphs, respectively. The IC(50) values of diclofenac sodium, ketoprofen, lornoxicam, propofol, tenoxicam, etomidate and morphine were 7.265, 6.278, 0.3, 0.242, 0.082, 0.0523 and 0.0128 mM and the K(i) constants were 23.97 +/- 2.1, 22.14 +/- 7.6, 0.42 +/- 0.18, 0.418 +/- 0.056, 0.13 +/- 0.025, 0.0725 +/- 0.0029 and 0.0165 +/- 0.0013 mM, respectively. While diclofenac sodium, ketoprofen, lornoxicam, tenoxicam etomidate and morphine showed competitive inhibition, propofol displayed noncompetitive inhibition. PMID:18608753

  5. Kinetics of Papain: An Introductory Biochemistry Laboratory Experiment

    NASA Astrophysics Data System (ADS)

    Cornely, Kathleen; Crespo, Eric; Earley, Michael; Kloter, Rachel; Levesque, Aime; Pickering, Mary

    1999-05-01

    Enzyme kinetics experiments are popular in the undergraduate laboratory. These experiments have pedagogic value because they reinforce the concepts of Michaelis-Menten kinetics covered in the lecture portion of the course and give students the experience of calculating kinetic constants from data they themselves have generated. In this experiment, we investigate the kinetics of the thiol protease papain. The source of the papain is commercially available papaya latex. A specific substrate, Na-benzoyl-arginine-p-nitroanilide (BAPNA), is used, which takes advantage of the fact that papain interacts with a phenylalanine residue two amino acids away from the peptide bond cleaved. Upon hydrolysis by papain, a bright yellow product is released, p-nitroaniline. This allows the reaction to be monitored spectrophotometrically by measuring the rate of formation of the p-nitroaniline product as a function of the increase in absorbance of the solution at the lmax of p-nitroaniline (400 nm) over time at various substrate concentrations. These data are used to plot a Lineweaver-Burk plot from which the vmax and KM are obtained. If time permits, students carry out additional investigations in which e of p-nitroaniline is measured, the enzyme solution protein concentration is measured, the enzyme purity is evaluated by SDS-PAGE, and a pH-rate profile is constructed from experimental data.

  6. Magnetostriction and magnetoelastic quantum oscillations in P-type lead telluride

    NASA Technical Reports Server (NTRS)

    Thompson, T. E.; Aron, P. R.; Chandrasekhar, B. S.; Langenberg, D. N.

    1972-01-01

    A detailed experimental and theoretical study of quantum oscillations in the magnetostriction and Young's modulus of p-PbTe is presented. The valance band of PbTe is approximated by a spheroidal, nonparabolic model in which the effects of strain on the valance band parameters are described by a deformation potential model. Using appropriate thermodynamic derivatives of the modified Lifshitz-Kosevich expression for the oscillatory parts of the electronic free energy, it is shown that both types of oscillations arise mainly from relative shifts of the valance band maxima due to shear strains, accompanied by intervalley charge transfer. Band parameters derived from the periods, phases, and spin splitting of the oscillations are in generally good agreement with values reported by other workers. A detailed comparison is made of the experimentally observed oscillation amplitudes with those predicted by theory, and satisfactory agreement is found. The ratio of the amplitudes of the two effects yields a value of the valance band deformation potential in good agreement with a value found from piezoresistance experiments by Burke.

  7. A new affinity method for purification of bovine testicular hyaluronidase enzyme and an investigation of the effects of some compounds on this enzyme.

    PubMed

    Kaya, Mustafa Oguzhan; Arslan, Oktay; Guler, Ozen Ozensoy

    2015-01-01

    In this study, a new affinity gel for the purification of bovine testicular hyaluronidase (BTH) was synthesized. L-Tyrosine was added as the extension arm to the Sepharose-4B activated with cyanogen bromide. m-Anisidine is a specific inhibitor of BTH enzyme. m-Anisidine was clamped to the newly formed Sepharose-4B-L-tyrosine as a ligand. As a result, an affinity gel having the chemical structure of Sepharose-4B-L-tyrosine-m-anisidine was obtained. BTH purified by ammonium sulfate precipitation and affinity chromatography was obtained with a 16.95% yield and 881.78 degree of purity. The kinetic constants K(M) and V(Max) for BTH were determined by using hyaluronic acid as a substrate. K(M) and V(Max) values obtained from the Lineweaver-Burk graph were found to be 2.23 mM and 19.85 U/mL, respectively. In vitro effects of some chemicals were determined on purified BTH enzyme. Some chemically active ingredients were 1,1-dimethyl piperidinium chloride, β-naphthoxyacetic acid and gibberellic acid. Gibberellic acid showed the best inhibition effect on BTH. PMID:25373501

  8. Relative stability and phase transitions under pressure of SrTiO3: ab initio FP-LAPW within GGA-PBEsol+TB-mBJ calculations

    NASA Astrophysics Data System (ADS)

    Benallou, Yassine; Soudini, Belabbas; Amara, Kadda

    2014-04-01

    In this paper, we report a density functional study of the structural, electronic and pressure-induced solid-solid phase transitions of SrTiO3. These first-principles calculations have been performed using the full potential linearized augmented plane wave method (FP-LAPW) within the generalized gradient approximation (GGA) developed by Perdew-Burke-Ernzerhor for solids (PBEsol). The calculated structural parameters like the lattice parameters, the bulk modulus B and their pressure derivative B‧ are used to analyze the relative stability and phase transitions under pressure of SrTiO3. Calculations were done for the cubic (Pm-3m), tetragonal (I4/mcm, P4/mbm, P4mm) and orthorhombic (Cmcm, Pnma) structures where we found that the tetragonal I4/mcm phase is the most stable structure compared to the other structures at T = 0 K and P = 0 GPa. For the electronic properties calculations, the exchange and correlation effects were treated by the Tran-Blaha modified Becke-Johnson (TB-mBJ) potential to prevent the shortcoming of the underestimation of the energy gaps in both LDA and GGA approximations. The obtained results are compared to available experimental data and to other theoretical calculations.

  9. Selective Inhibition of Bakuchicin Isolated from Psoralea corylifolia on CYP1A in Human Liver Microsomes

    PubMed Central

    Kim, Sun Joo; Oh, Heung Chan; Kim, Youn-Chul; Jeong, Gil-Saeng; Lee, Sangkyu

    2016-01-01

    Bakuchicin is a furanocoumarin isolated from Psoralea corylifolia and shows several biological activities. Although there have been studies on the biological effects of bakuchicin, its modulation potency of CYP activities has not been previously investigated. Here, we investigated the inhibitory effects of bakuchicin on the activities of CYP isoforms by using a cocktail of probe substrates in pooled human liver microsomes (HLMs) and human recombinant cDNA-expressed CYP. Bakuchicin strongly inhibited CYP1A-mediated phenacetin O-deethylation with an IC50 value of 0.43 μM in HLMs. It was confirmed by human recombinant cDNA-expressed CYP1A1 and CYP1A2 with a Ki value of 0.11 μM and 0.32 μM, respectively. A Lineweaver-Burk plot indicated that the inhibition mechanism of bakuchicin was competitive inhibition. Overall, this is the first study to investigate the potential CYP1A1 and CYP1A2 inhibition associated with bakuchicin and to report its competitive inhibitory effects on HLMs. PMID:26977174

  10. Stationary state Kohn-Sham Theory: Modern algorithms breathe new life into an old theory

    NASA Astrophysics Data System (ADS)

    Gunceler, Deniz; Sundararaman, Ravishankar; Arias, T. A.

    2014-03-01

    In this talk, we will discuss stationary-state Kohn-Sham theory, an old (Phys. Rev. B 31, 6264-6272) but largely ignored idea that is recently undergoing revival. It is based on an in-principle exact scheme in which excited states are computed as the stationary states of the Hohenberg-Kohn functional. We will discuss the objections of Gaudoin and Burke (Phys. Rev. Lett. 93, 17), and also describe the computational difficulties which prevented this theory from becoming popular in the past, and present new algorithms for computing the predictions of this theory. The resulting technique has inherent computational advantages over TDDFT and GW, and results using semilocal functionals show great promise for molecules. However, the method as implemented exhibits large errors for solids. In this talk, we shall show that the origin of this behaviour is related to the fact that different errors dominate the solid and molecular cases, and we shall discuss prospects for improvement of the theory in the future.

  11. EZ-FIT: a practical curve-fitting microcomputer program for the analysis of enzyme kinetic data on IBM-PC compatible computers.

    PubMed

    Perrella, F W

    1988-11-01

    EZ-FIT, an interactive microcomputer software package, has been developed for the analysis of enzyme kinetic and equilibrium binding data. EZ-FIT was designed as a user-friendly menu-driven package that has the facility for data entry, editing, and filing. Data input permits the conversion of cpm, dpm, or optical density to molar per minute per milligram protein. Data can be fit to any of 14 model equations including Michaelis-Menten, Hill, isoenzyme, inhibition, dual substrate, agonist, antagonist, and modified integrated Michaelis-Menten. The program uses the Nelder-Mead simplex and Marquardt nonlinear regression algorithms sequentially. A report of the results includes the parameter estimates with standard errors, a Student t test to determine the accuracy of the parameter values, a Runs statistic test of the residuals, identification of outlying data, an Akaike information criterion test for goodness-of-fit, and, when the experimental variance is included, a chi 2 statistic test for goodness-of-fit. Several different graphs can be displayed: an X-Y, a Scatchard, an Eadie-Hofstee, a Lineweaver-Burk, a semilogarithmic, and a residual plot. A data analysis report and graphs are designed to evaluate the goodness-of-fit of the data to a particular model. PMID:3239747

  12. Effects of Pu-erh tea aqueous extract (PTAE) on blood lipid metabolism enzymes.

    PubMed

    Zeng, Liang; Yan, Jingna; Luo, Liyong; Zhang, Dongying

    2015-06-01

    Disorders of blood lipid metabolism are the primary risk factors for many diseases. Recently, the effect of Pu-erh tea on blood lipid metabolism has received increasing attention. However, the mechanism underlying its ability to regulate blood lipid metabolism is unclear. We set out to study this through assessing the effects of Pu-erh tea aqueous extract (PTAE) on the central enzymes of blood lipid metabolism, including lipoprotein-associated phospholipase A2 (Lp-PLA2), lecithin: cholesterol acyltransferase (LCAT), 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) and pancreatic lipase (PL). We find that the Lp-PLA2, HMRG and PL activities are inhibited by PTAE in a dose-dependent manner and that the LCAT activity tends to increase with increasing PTAE concentrations. Lineweaver-Burk plot analyses reveal that PTAE acts as a competitive inhibitor for HMGR and PL and as a noncompetitive inhibitor for Lp-PLA2. Moreover, we determine that its active ingredients include catechins, gallic acid, caffeine, free amino acids, and soluble sugar. However, the effect of each ingredient and whether any of them have synergistic effects are still unknown. The results suggest that Pu-erh tea has a potent ability to regulate blood lipid metabolism and knowledge of the mechanisms provides insights into its potential therapeutic application as an alternative hypolipidemic drug. PMID:26018873

  13. High pressure ionic and molecular crystals of ammonia monohydrate within density functional theory.

    PubMed

    Griffiths, Gareth I G; Misquitta, Alston J; Fortes, A Dominic; Pickard, Chris J; Needs, Richard J

    2012-08-14

    A combination of first-principles density functional theory calculations and a search over structures is used to predict the stability of a proton-transfer modification of ammonia monohydrate with space group P4∕nmm. The phase diagram is calculated with the Perdew-Burke-Ernzerhof (PBE) density functional, and the effects of a semi-empirical dispersion correction, zero point motion, and finite temperature are investigated. Comparison with MP2 and coupled cluster calculations shows that the PBE functional over-stabilizes proton transfer phases because too much electronic charge moves with the proton. This over-binding is partially corrected by using the PBE0 hybrid exchange-correlation functional, which increases the enthalpy of P4∕nmm by about 0.6 eV per formula unit relative to phase I of ammonia monohydrate and shifts the transition to the proton transfer phase from the PBE pressure of 2.8 GPa to about 10 GPa. This is consistent with experiment as proton transfer phases have not been observed at pressures up to ∼9 GPa, while higher pressures have not yet been explored experimentally. PMID:22897292

  14. Searching for indole derivatives as potential mushroom tyrosinase inhibitors.

    PubMed

    Ferro, Stefania; Certo, Giovanna; De Luca, Laura; Germanò, Maria Paola; Rapisarda, Antonio; Gitto, Rosaria

    2016-06-01

    Tyrosinase is a copper-containing enzyme widely distributed in nature, involved in the biosynthesis of melanin whose role is to protect the skin from ultraviolet damage. A great interest has been shown on the melanin involvement in malignant melanoma and other carcinogenetic processes. These phenomena have encouraged the research of tyrosinase inhibitors useful in therapeutic field as well as in foods and cosmetics to prevent browning. The idea was to screen our "in house" database to select suitable lead compounds for the discovery of potential drug-inhibiting enzyme. The obtained biological results demonstrated that compounds containing 4-fluorobenzyl moiety at N - 1 position of indole system showed the best activity. In addition, the role of the portion linked to the carbonyl group at C - 3 was discussed. A Lineweaver-Burk kinetic analysis of the most active indoles, CHI 1043 and derivative 4, showed a mixed-type inhibition in the presence of l-3,4-dihydroxyphenylalanine (l-DOPA) as substrate. PMID:25826148

  15. Bordetella pertussis major outer membrane porin protein forms small, anion-selective channels in lipid bilayer membranes.

    PubMed Central

    Armstrong, S K; Parr, T R; Parker, C D; Hancock, R E

    1986-01-01

    The major outer membrane protein of molecular weight 40,000 (the 40K protein) of a virulent isolate of Bordetella pertussis was purified to apparent homogeneity. The purified protein formed an oligomer band (of apparent molecular weight 90,000) on sodium dodecyl sulfate-polyacrylamide gels after solubilization at low temperatures. The porin function of this protein was characterized by the black lipid bilayer method. The 40K protein formed channels smaller than all other constitutive major outer membrane porins studied to date. The average single-channel conductance in 1 M KCl was 0.56 nS. This was less than a third of the conductance previously observed for Escherichia coli porins. Zero-current potential measurements made of the porin to determine its ion selectivity revealed the porin to be more than 100-fold selective for anions over cations. The single-channel conductance was measured as a function of salt concentration. The data could be fitted to a Lineweaver-Burk plot suggesting an anion binding site with a Kd of 1.17 M Cl- and a maximum possible conductance through the channel of 1.28 nS. Images PMID:2420780

  16. PBE-DFT theoretical study of organic photovoltaic materials based on thiophene with 1D and 2D periodic boundary conditions

    NASA Astrophysics Data System (ADS)

    Saïl, K.; Bassou, G.; Gafour, M. H.; Miloua, F.

    2015-12-01

    Conjugated organic systems such as thiophene are interesting topics in the field of organic solar cells. We theoretically investigate π-conjugated polymers constituted by n units ( n = 1-11) based on the thiophene (Tn) molecule. The computations of the geometries and electronic structures of these compounds are performed using the density functional theory (DFT) at the 6-31 G( d, p) level of theory and the Perdew-Burke-Eenzerhof (PBE) formulation of the generalized gradient approximation with periodic boundary conditions (PBCs) in one (1D) and two (2D) dimensions. Moreover, the electronic properties (HOCO, LUCO, E gap, V oc, and V bi) are determined from 1D and 2D PBC to understand the effect of the number of rings in polythiophene. The absorption properties—excitation energies ( E ex), the maximal absorption wavelength (λmax), oscillator strengths, and light harvesting—efficiency are studied using the time-dependent DFT method. Our studies show that changing the number of thiophene units can effectively modulate the electronic and optical properties. On the other hand, our work demonstrates the efficiency of theoretical calculation in the PBCs.

  17. Metabolic inhibition and kinetics of raloxifene by pharmaceutical excipients in human liver microsomes.

    PubMed

    Kim, Ae Ra; Lim, Soo-Jeong; Lee, Beom-Jin

    2009-02-23

    This study was originally undertaken to establish the in vitro metabolic conditions and then evaluate the effect of pharmaceutical excipients (PEs) on drug metabolism in uridine diphosphoglucuronic acid-supplemented human liver microsomes. Poorly bioavailable raloxifene was chosen as a model drug. Intact drug and its two glucuronide metabolites were successfully isolated using gradient HPLC analysis and LC/MS analysis. Formation of raloxifene metabolites was affected by buffer compositions, incubation time and initial raloxifene concentrations. Under optimized metabolic conditions, 41.0% of raloxifene was converted to its metabolites after 2h incubation. This metabolic inhibition of raloxifene by the PEs occurred in a dose-dependent manner and accordingly formed two glucuronide metabolites. In the metabolic kinetics using Lineweaver-Burk analyses, Cremophor EL competitively inhibited formation of metabolites while sodium lauryl sulfate (SLS), polyvinylpyrrolidone K30 (PVP) and Tween 80 significantly inhibited in a mixed competition. Although some PEs showed inhibition on glucuronidation of raloxifene in vitro, their effects on in vivo bioavailability of raloxifene need to be confirmed directly due to the dilution factors and other complicated situations influencing the bioavailability. PMID:18977285

  18. Making scenes: imaginative practices of a child with autism in a sensory integration-based therapy session.

    PubMed

    Park, Melissa

    2008-09-01

    A tension in medical anthropology, as an interdisciplinary field, exists between those polar territories of the logic--and therefore grammars--of a positivist-scientific stance of biomedicine and a literary-philosophical one used to represent experience. Taking up literary-philosophical and existential perspectives from anthropology proper, I draw on an ethnographic study of a sensory-integration-based clinic to propose that imaginative practices are one arena where such tension can be worked out. Enacted narratives, as a method, reveal how imaginative practices foreground the ways in which desire and hope are integral to healing. Kenneth Burke's (1969 [1945]) theory of dramatism, particularly his scene : act ratio, provides an analytic lens to examine the imaginary play of a singular session between a child with autism and an occupational therapist. Further, an interpretive frame that tacks between the positivist-biomedical and literary-philosophical discourses excavates how making scenes is integral to a healing of belonging and its embodiment. PMID:19014014

  19. Ab initio molecular dynamics of solvation effects on reactivity at electrified interfaces.

    PubMed

    Herron, Jeffrey A; Morikawa, Yoshitada; Mavrikakis, Manos

    2016-08-23

    Using ab initio molecular dynamics as implemented in periodic, self-consistent (generalized gradient approximation Perdew-Burke-Ernzerhof) density functional theory, we investigated the mechanism of methanol electrooxidation on Pt(111). We investigated the role of water solvation and electrode potential on the energetics of the first proton transfer step, methanol electrooxidation to methoxy (CH3O) or hydroxymethyl (CH2OH). The results show that solvation weakens the adsorption of methoxy to uncharged Pt(111), whereas the binding energies of methanol and hydroxymethyl are not significantly affected. The free energies of activation for breaking the C-H and O-H bonds in methanol were calculated through a Blue Moon Ensemble using constrained ab initio molecular dynamics. Calculated barriers for these elementary steps on unsolvated, uncharged Pt(111) are similar to results for climbing-image nudged elastic band calculations from the literature. Water solvation reduces the barriers for both C-H and O-H bond activation steps with respect to their vapor-phase values, although the effect is more pronounced for C-H bond activation, due to less disruption of the hydrogen bond network. The calculated activation energy barriers show that breaking the C-H bond of methanol is more facile than the O-H bond on solvated negatively biased or uncharged Pt(111). However, with positive bias, O-H bond activation is enhanced, becoming slightly more facile than C-H bond activation. PMID:27503889

  20. Ab initio thermodynamic model for magnesium carbonates and hydrates.

    PubMed

    Chaka, Anne M; Felmy, Andrew R

    2014-09-01

    An ab initio thermodynamic framework for predicting properties of hydrated magnesium carbonate minerals has been developed using density-functional theory linked to macroscopic thermodynamics through the experimental chemical potentials for MgO, water, and CO2. Including semiempirical dispersion via the Grimme method and small corrections to the generalized gradient approximation of Perdew, Burke, and Ernzerhof for the heat of formation yields a model with quantitative agreement for the benchmark minerals brucite, magnesite, nesquehonite, and hydromagnesite. The model shows how small differences in experimental conditions determine whether nesquehonite, hydromagnesite, or magnesite is the result of laboratory synthesis from carbonation of brucite, and what transformations are expected to occur on geological time scales. Because of the reliance on parameter-free first-principles methods, the model is reliably extensible to experimental conditions not readily accessible to experiment and to any mineral composition for which the structure is known or can be hypothesized, including structures containing defects, substitutions, or transitional structures during solid state transformations induced by temperature changes or processes such as water, CO2, or O2 diffusion. Demonstrated applications of the ab initio thermodynamic framework include an independent means to evaluate differences in thermodynamic data for lansfordite, predicting the properties of Mg analogues of Ca-based hydrated carbonates monohydrocalcite and ikaite, which have not been observed in nature, and an estimation of the thermodynamics of barringtonite from the stoichiometry and a single experimental observation. PMID:24679248