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  1. Pentosan Polysulfate

    MedlinePlus

    Pentosan polysulfate comes as a capsule to take by mouth. It is usually taken with water three times a day, 1 hour before or 2 hours after ... stools bloody vomit vomiting material that looks like coffee grounds Pentosan polysulfate may cause other side effects. ...

  2. Pentosan Polysulfate

    MedlinePlus

    ... a class of medications called low molecular weight heparins. It works by preventing irritation of the bladder ... you are allergic to pentosan polysulfate, danaparoid (Orgaran), heparin, or any other medications.tell your doctor and ...

  3. 75 FR 53704 - Prospective Grant of Exclusive License: Use of Pentosan Polysulfate To Treat Certain Conditions...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-01

    ... Polysulfate To Treat Certain Conditions of the Prostate AGENCY: National Institutes of Health, Public Health... December 07, 2004, entitled, ``USE OF PENTOSAN POLYSULFATE TO TREAT CERTAIN CONDITIONS OF THE PROSTATE...@mail.nih.gov . SUPPLEMENTARY INFORMATION: This technology is a method for treating Benign...

  4. Pentosan Polysulfate: A Novel Therapy for the Mucopolysaccharidoses

    PubMed Central

    Schuchman, Edward H.; Ge, Yi; Lai, Alon; Borisov, Yury; Faillace, Meghan; Eliyahu, Efrat; He, Xingxuan; Iatridis, James; Vlassara, Helen; Striker, Gary; Simonaro, Calogera M.

    2013-01-01

    Background Pentosan polysulfate (PPS) is an FDA-approved, oral medication with anti-inflammatory and pro-chondrogenic properties. We have previously shown that animal models of the mucopolysaccharidoses (MPS) exhibit significant inflammatory disease, contributing to cartilage degeneration. Enzyme replacement therapy (ERT) only partly reduced inflammation, and anti-TNF-alpha antibody therapy significantly enhanced clinical and pathological outcomes. Here we describe the use of PPS for the treatment of MPS type VI rats. Methodology/Principal Findings Treatment began during prenatal development and at 1 and 6 months of age. All animals were treated until they were 9 months old. Significant reductions in the serum and tissue levels of several inflammatory markers (e.g., TNF-alpha, MIP-1alpha and RANTES/CCL5) were observed, as was reduced expression of inflammatory markers in cultured articular chondrocytes. ADAMTS-5/aggrecanase-2 levels also were reduced in chondrocytes, consistent with an elevation of serum tissue inhibitor of metalloproteinase 1. Marked improvements in motility and grooming behavior occurred, along with a reduction in eye and nasal secretions and a lessening of the tracheal deformities. MicroCT and radiographic analyses further revealed that the treated MPS skulls were longer and thinner, and that the teeth malocclusions, misalignments and mineral densities were improved. MicroCT analysis of the femurs and vertebrae revealed improvements in trabecular bone mineral densities, number and spacing in a subset of treated MPS animals. Biomechanical assessments of PPS-treated spines showed partially restored torsional behaviors, suggesting increased spinal stability. No improvements were observed in cortical bone or femur length. The positive changes in the PPS-treated MPS VI rats occurred despite glycosaminoglycan accumulation in their tissues. Conclusions Based on these findings we conclude that PPS could be a simple and effective therapy for MPS that

  5. 77 FR 58399 - Draft Guidance for Industry on Bioequivalence Recommendations for Pentosan Polysulfate Sodium...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-20

    .... SUPPLEMENTARY INFORMATION: I. Background In the Federal Register of June 11, 2010 (75 FR 33311; FDA-2007-D- 0433... recommendations provide specific guidance on the design of bioequivalence (BE) studies to support abbreviated new... on the design of BE studies to support ANDAs for pentosan polysulfate sodium capsule. It does...

  6. Effect of pentosan polysulfate (SP 54) on the reverse transcriptase activity of several retroviruses.

    PubMed

    Sydow, G; Klöcking, H P

    1987-01-01

    Pentosan polysulfate (SP 54), a low molecular weight sulfated polysaccharide, was studied in vitro for its effect on the reverse transcriptase activity of seven retroviruses. Six of them possess an enzyme with high sensitivity against SP 54, while the enzyme of one virus (bovine leucosis virus) proved to be insensitive within the concentration range tested. In comparison with other polyanionic compounds so far tested, SP 54 seems to be one of the most active in vitro inhibitors of retrovirus-specific reverse transcriptase. PMID:2445339

  7. Pentosan Polysulfate: Oral Versus Subcutaneous Injection in Mucopolysaccharidosis Type I Dogs

    PubMed Central

    Simonaro, Calogera M.; Tomatsu, Shunji; Sikora, Tracy; Kubaski, Francyne; Frohbergh, Michael; Guevara, Johana M.; Wang, Raymond Y.; Vera, Moin; Kang, Jennifer L.; Smith, Lachlan J.; Schuchman, Edward H.; Haskins, Mark E.

    2016-01-01

    Background We previously demonstrated the therapeutic benefits of pentosan polysulfate (PPS) in a rat model of mucopolysaccharidosis (MPS) type VI. Reduction of inflammation, reduction of glycosaminoglycan (GAG) storage, and improvement in the skeletal phenotype were shown. Herein, we evaluate the long-term safety and therapeutic effects of PPS in a large animal model of a different MPS type, MPS I dogs. We focused on the arterial phenotype since this is one of the most consistent and clinically significant features of the model. Methodology/Principal Findings MPS I dogs were treated with daily oral or biweekly subcutaneous (subQ) PPS at a human equivalent dose of 1.6 mg/kg for 17 and 12 months, respectively. Safety parameters were assessed at 6 months and at the end of the study. Following treatment, cytokine and GAG levels were determined in fluids and tissues. Assessments of the aorta and carotid arteries also were performed. No drug-related increases in liver enzymes, coagulation factors, or other adverse effects were observed. Significantly reduced IL-8 and TNF-alpha were found in urine and cerebrospinal fluid (CSF). GAG reduction was observed in urine and tissues. Increases in the luminal openings and reduction of the intimal media thickening occurred in the carotids and aortas of PPS-treated animals, along with a reduction of storage vacuoles. These results were correlated with a reduction of GAG storage, reduction of clusterin 1 staining, and improved elastin integrity. No significant changes in the spines of the treated animals were observed. Conclusions PPS treatment led to reductions of pro-inflammatory cytokines and GAG storage in urine and tissues of MPS I dogs, which were most evident after subQ administration. SubQ administration also led to significant cytokine reductions in the CSF. Both treatment groups exhibited markedly reduced carotid and aortic inflammation, increased vessel integrity, and improved histopathology. We conclude that PPS may be a

  8. Pentosan Polysulfate: a Novel Glycosaminoglycan-Like Molecule for Effective Treatment of Alphavirus-Induced Cartilage Destruction and Inflammatory Disease

    PubMed Central

    Foo, Suan-Sin; Sheng, Kuo-Ching; Chen, Weiqiang; Forwood, Mark R.; Bucala, Richard

    2015-01-01

    ABSTRACT Arthritogenic alphaviruses such as Ross River virus (RRV) and chikungunya virus (CHIKV) cause large-scale epidemics of severe musculoskeletal disease and have been progressively expanding their global distribution. Since its introduction in July 2014, CHIKV now circulates in the United States. The hallmark of alphavirus disease is crippling pain and inflammation of the joints, a similar immunopathology to rheumatoid arthritis. The use of glycans as novel therapeutics is an area of research that has increased in recent years. Here, we describe the promising therapeutic potential of the glycosaminoglycan (GAG)-like molecule pentosan polysulfate (PPS) to alleviate virus-induced arthritis. Mouse models of RRV and CHIKV disease were used to characterize the extent of cartilage damage in infection and investigate the potential of PPS to treat disease. This was assessed using histological analysis, real-time PCR, and fluorescence-activated cell sorting (FACS). Alphaviral infection resulted in cartilage destruction, the severity of which was alleviated by PPS therapy during RRV and CHIKV clinical disease. The reduction in cartilage damage corresponded with a significant reduction in immune infiltrates. Using multiplex bead arrays, PPS treatment was found to have significantly increased the anti-inflammatory cytokine interleukin-10 and reduced proinflammatory cytokines, typically correlated with disease severity. Furthermore, we reveal that the severe RRV-induced joint pathology, including thinning of articular cartilage and loss of proteoglycans in the cartilage matrix, was diminished with treatment. PPS is a promising new therapy for alphavirus-induced arthritis, acting to preserve the cartilage matrix, which is damaged during alphavirus infection. Overall, the data demonstrate the potential of glycotherapeutics as a new class of treatment for infectious arthritis. IMPORTANCE The hallmark of alphavirus disease is crippling pain and joint arthritis, which often

  9. Pentosan polysulfate inhibits atherosclerosis in Watanabe heritable hyperlipidemic rabbits: differential modulation of metalloproteinase-2 and -9.

    PubMed

    Lupia, Enrico; Zheng, Feng; Grosjean, Fabrizio; Tack, Ivan; Doublier, Sophie; Elliot, Sharon J; Vlassara, Helen; Striker, Gary E

    2012-02-01

    Pentosan polysulfate (PPS), a heparinoid compound essentially devoid of anticoagulant activity, modulates cell growth and decreases inflammation. We investigated the effect of PPS on the progression of established atherosclerosis in Watanabe heritable hyperlipidemic (WHHL) rabbits. After severe atherosclerosis developed on an atherogenic diet, WHHL rabbits were treated with oral PPS or tap water for 1 month. The aortic intima-to-media ratio and macrophage infiltration were reduced, plaque collagen content was increased, and plaque fibrous caps were preserved by PPS treatment. Plasma lipid levels and post-heparin hepatic lipase activity remained unchanged. However, net collagenolytic activity in aortic extracts was decreased, and the levels of matrix metalloproteinase (MMP)-2 and tissue inhibitor of metalloproteinase (TIMP) activity were increased by PPS. Moreover, PPS treatment decreased tumor necrosis factor α (TNFα)-stimulated proinflammatory responses, in particular activation of nuclear factor-κB and p38, and activation of MMPs in macrophages. In conclusion, oral PPS treatment prevents progression of established atherosclerosis in WHHL rabbits. This effect may be partially mediated by increased MMP-2 and TIMP activities in the aortic wall and reduced TNFα-stimulated inflammation and MMP activation in macrophages. Thus, PPS may be a useful agent in inhibiting the progression of atherosclerosis. PMID:22042083

  10. Pentosan polysulfate increases affinity between ADAMTS-5 and TIMP-3 through formation of an electrostatically driven trimolecular complex.

    PubMed

    Troeberg, Linda; Mulloy, Barbara; Ghosh, Peter; Lee, Meng-Huee; Murphy, Gillian; Nagase, Hideaki

    2012-04-01

    The semi-synthetic sulfated polysaccharide PPS (pentosan polysulfate) increases affinity between the aggrecan-degrading ADAMTSs (adamalysins with thrombospondin motifs) and their endogenous inhibitor, TIMP (tissue inhibitor of metalloproteinases)-3. In the present study we demonstrate that PPS mediates the formation of a high-affinity trimolecular complex with ADAMTS-5 and TIMP-3. A TIMP-3 mutant that lacks extracellular-matrix-binding ability was insensitive to this affinity increase, and truncated forms of ADAMTS-5 that lack the Sp (spacer) domain had reduced PPS-binding ability and sensitivity to the affinity increase. PPS molecules composed of 11 or more saccharide units were 100-fold more effective than those of eight saccharide units, indicating the involvement of extended or multiple protein-interaction sites. The formation of a high-affinity trimolecular complex was completely abolished in the presence of 0.4 M NaCl. These results suggest that PPS enhances the affinity between ADAMTS-5 and TIMP-3 by forming electrostatically driven trimolecular complexes under physiological conditions. PMID:22299597

  11. Pentosan polysulfate promotes proliferation and chondrogenic differentiation of adult human bone marrow-derived mesenchymal precursor cells

    PubMed Central

    2010-01-01

    Introduction This study was undertaken to determine whether the anti-osteoarthritis drug pentosan polysulfate (PPS) influenced mesenchymal precursor cell (MPC) proliferation and differentiation. Methods Human MPCs were maintained in monolayer, pellet or micromass cultures (MMC) for up to 10 days with PPS at concentrations of 0 to 20 μg/ml. MPC viability and proliferation was assessed using the WST-1 assay and 3H-thymidine incorporation into DNA, while apoptosis was monitored by flow cytometry. Proteoglycan (PG) biosynthesis was determined by 35SO42- incorporation and staining with Alcian blue. Proteoglycan and collagen type I and collagen type II deposition in pellet cultures was also examined by Toluidine blue and immunohistochemical staining, respectively. The production of hyaluronan (HA) by MPCs in MMC was assessed by ELISA. The relative outcome of PPS, HA, heparin or dextran sulfate (DS) on PG synthesis was compared in 5-day MMC. Gene expression of MPCs in 7-day and 10-day MMC was examined using real-time PCR. MPC differentiation was investigated by co-culturing with PPS in osteogenic or adipogenic inductive culture media for 28 days. Results Significant MPC proliferation was evident by day 3 at PPS concentrations of 1 to 5 μg/ml (P < 0.01). In the presence of 1 to 10 μg/ml PPS, a 38% reduction in IL-4/IFNγ-induced MPC apoptosis was observed. In 5-day MMC, 130% stimulation of PG synthesis occurred at 2.5 μg/ml PPS (P < 0.0001), while 5.0 μg/ml PPS achieved maximal stimulation in the 7-day and 10-day cultures (P < 0.05). HA and DS at ≥ 5 μg/ml inhibited PG synthesis (P < 0.05) in 5-day MMC. Collagen type II deposition by MMC was significant at ≥ 0.5 μg/ml PPS (P < 0.001 to 0.05). In MPC-PPS pellet cultures, more PG, collagen type II but less collagen type I was deposited than in controls. Real-time PCR results were consistent with the protein data. At 5 and 10 μg/ml PPS, MPC osteogenic differentiation was suppressed (P < 0.01). Conclusions This is

  12. Pentosan polysulfate preserves renal microvascular P2X1 receptor reactivity and autoregulatory behavior in DOCA-salt hypertensive rats.

    PubMed

    Guan, Zhengrong; Singletary, Sean T; Cha, Haword; Van Beusecum, Justin P; Cook, Anthony K; Pollock, Jennifer S; Pollock, David M; Inscho, Edward W

    2016-03-15

    Inflammation contributes to ANG II-associated impairment of renal autoregulation and microvascular P2X1 receptor signaling, but its role in renal autoregulation in mineralocorticoid-induced hypertension is unknown. Autoregulatory behavior was assessed using the blood-perfused juxtamedullary nephron preparation. Hypertension was induced in uninephrectomized control rats (UNx) by subcutaneous implantation of a DOCA pellet plus administration of 1% NaCl in the drinking water (DOCA-salt) for 3 wk. DOCA-salt rats developed hypertension that was unaltered by anti-inflammatory treatment with pentosan polysulfate (DOCA-salt+PPS) but was suppressed with "triple therapy" (hydrochlorothiazide, hydralazine, and reserpine; DOCA-salt+TTx). Baseline arteriolar diameters were similar across all groups. UNx rats exhibited pressure-dependent vasoconstriction with diameters declining to 69 ± 2% of control at 170 mmHg, indicating intact autoregulation. DOCA-salt treatment significantly blunted this pressure-mediated vasoconstriction. Diameters remained between 91 ± 4 and 98 ± 3% of control over 65-170 mmHg, indicating impaired autoregulation. In contrast, pressure-mediated vasoconstriction was preserved in DOCA-salt+PPS and DOCA-salt+TTx rats, reaching 77 ± 7 and 75 ± 3% of control at 170 mmHg, respectively. ATP is required for autoregulation via P2X1 receptor activation. ATP- and β,γ-methylene ATP (P2X1 receptor agonist)-mediated vasoconstriction were markedly attenuated in DOCA-salt rats compared with UNx (P < 0.05), but significantly improved by PPS or TTx (P < 0.05 vs. DOCA-salt) treatment. Arteriolar responses to adenosine and UTP (P2Y2 receptor agonist) were unaffected by DOCA-salt treatment. PPS and TTx significantly reduced MCP-1 and protein excretion in DOCA-salt rats. These results support the hypothesis that hypertension triggers inflammatory cascades but anti-inflammatory treatment preserves renal autoregulation in DOCA-salt rats, most likely by normalizing renal

  13. Reconstitution of degenerated ovine lumbar discs by STRO-3-positive allogeneic mesenchymal precursor cells combined with pentosan polysulfate.

    PubMed

    Oehme, David; Ghosh, Peter; Goldschlager, Tony; Itescu, Silviu; Shimon, Susan; Wu, Jiehua; McDonald, Courtney; Troupis, John M; Rosenfeld, Jeffrey V; Jenkin, Graham

    2016-05-01

    OBJECTIVE Disc degeneration and associated low-back pain are major causes of suffering and disability. The authors examined the potential of mesenchymal precursor cells (MPCs), when formulated with pentosan polysulfate (PPS), to ameliorate disc degeneration in an ovine model. METHODS Twenty-four sheep had annular incisions made at L2-3, L3-4, and L4-5 to induce degeneration. Twelve weeks after injury, the nucleus pulposus of a degenerated disc in each animal was injected with ProFreeze and PPS formulated with either a low dose (0.1 million MPCs) or a high dose (0.5 million MPCs) of cells. The 2 adjacent injured discs in each spine were either injected with PPS and ProFreeze (PPS control) or not injected (nil-injected control). The adjacent noninjured L1-2 and L5-6 discs served as noninjured control discs. Disc height indices (DHIs) were obtained at baseline, before injection, and at planned death. After necropsy, 24 weeks after injection, the spines were subjected to MRI and morphological, histological, and biochemical analyses. RESULTS Twelve weeks after the annular injury, all the injured discs exhibited a significant reduction in mean DHI (low-dose group 17.19%; high-dose group 18.01% [p < 0.01]). Twenty-four weeks after injections, the discs injected with the low-dose MPC+PPS formulation recovered disc height, and their mean DHI was significantly greater than the DHI of PPS- and nil-injected discs (p < 0.001). Although the mean Pfirrmann MRI disc degeneration score for the low-dose MPC+PPS-injected discs was lower than that for the nil- and PPS-injected discs, the differences were not significant. The disc morphology scores for the nil- and PPS-injected discs were significantly higher than the normal control disc scores (p < 0.005), whereas the low-dose MPC+PPS-injected disc scores were not significantly different from those of the normal controls. The mean glycosaminoglycan content of the nuclei pulposus of the low-dose MPC+PPS-injected discs was significantly

  14. Dose Responsive Effects of Subcutaneous Pentosan Polysulfate Injection in Mucopolysaccharidosis Type VI Rats and Comparison to Oral Treatment

    PubMed Central

    Frohbergh, Michael; Ge, Yi; Meng, Fanli; Karabul, Nesrin; Solyom, Alexander; Lai, Alon; Iatridis, James; Schuchman, Edward H.; Simonaro, Calogera M.

    2014-01-01

    Background We previously demonstrated the benefits of daily, oral pentosan polysulfate (PPS) treatment in a rat model of mucopolysaccharidosis (MPS) type VI. Herein we compare these effects to once weekly, subcutaneous (sc) injection. The bioavailability of injected PPS is greater than oral, suggesting better delivery to difficult tissues such as bone and cartilage. Injected PPS also effectively treats osteoarthritis in animals, and has shown success in osteoarthritis patients. Methodology/Principal Findings One-month-old MPS VI rats were given once weekly sc injections of PPS (1, 2 and 4 mg/kg, human equivalent dose (HED)), or daily oral PPS (4 mg/kg HED) for 6 months. Serum inflammatory markers and total glycosaminoglycans (GAGs) were measured, as were several histological, morphological and functional endpoints. Overall, weekly sc PPS injections led to similar or greater therapeutic effects as daily oral administration. Common findings between the two treatment approaches included reduced serum inflammatory markers, improved dentition and skull lengths, reduced tracheal deformities, and improved mobility. Enhanced effects of sc treatment included GAG reduction in urine and tissues, greater endurance on a rotarod, and better improvements in articular cartilage and bone in some dose groups. Optimal therapeutic effects were observed at 2 mg/kg, sc. No drug-related increases in liver enzymes, coagulation factor abnormalities or other adverse effects were identified following 6 months of sc PPS administration. Conclusions Once weekly sc administration of PPS in MPS VI rats led to equal or better therapeutic effects than daily oral administration, including a surprising reduction in urine and tissue GAGs. No adverse effects from sc PPS administration were observed over the 6-month study period. PMID:24964042

  15. Pentosan polysulfate treatment ameliorates motor function with increased serum soluble vascular cell adhesion molecule-1 in HTLV-1-associated neurologic disease.

    PubMed

    Nakamura, Tatsufumi; Satoh, Katsuya; Fukuda, Taku; Kinoshita, Ikuo; Nishiura, Yoshihiro; Nagasato, Kunihiko; Yamauchi, Atsushi; Kataoka, Yasufumi; Nakamura, Tadahiro; Sasaki, Hitoshi; Kumagai, Kenji; Niwa, Masami; Noguchi, Mitsuru; Nakamura, Hideki; Nishida, Noriyuki; Kawakami, Atsushi

    2014-06-01

    The main therapeutic strategy against human T lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) characterized by lower extremity motor dysfunction is immunomodulatory treatment, with drugs such as corticosteroid hormone and interferon-α, at present. However, there are many issues in long-term treatment with these drugs, such as insufficient effects and various side effects. We now urgently need to develop other therapeutic strategies. The heparinoid, pentosan polysulfate sodium (PPS), has been safely used in Europe for the past 50 years as a thrombosis prophylaxis and for the treatment of phlebitis. We conducted a clinical trial to test the effect of subcutaneous administration of PPS in 12 patients with HAM/TSP in an open-labeled design. There was a marked improvement in lower extremity motor function, based on reduced spasticity, such as a reduced time required for walking 10 m and descending a flight of stairs. There were no significant changes in HTLV-I proviral copy numbers in peripheral blood contrary to the inhibitory effect of PPS in vitro for intercellular spread of HTLV-I. However, serum soluble vascular cell adhesion molecule (sVCAM)-1 was significantly increased without significant changes of serum level of chemokines (CXCL10 and CCL2). There was a positive correlation between increased sVCAM-1and reduced time required for walking 10 m. PPS might induce neurological improvement by inhibition of chronic inflammation in the spinal cord, through blocking the adhesion cascade by increasing serum sVCAM-1, in addition to rheological improvement of the microcirculation. PPS has the potential to be a new therapeutic tool for HAM/TSP. PMID:24671717

  16. Comparison of the anti-prion mechanism of four different anti-prion compounds, anti-PrP monoclonal antibody 44B1, pentosan polysulfate, chlorpromazine, and U18666A, in prion-infected mouse neuroblastoma cells.

    PubMed

    Yamasaki, Takeshi; Suzuki, Akio; Hasebe, Rie; Horiuchi, Motohiro

    2014-01-01

    Molecules that inhibit the formation of an abnormal isoform of prion protein (PrP(Sc)) in prion-infected cells are candidate therapeutic agents for prion diseases. Understanding how these molecules inhibit PrP(Sc) formation provides logical basis for proper evaluation of their therapeutic potential. In this study, we extensively analyzed the effects of the anti-PrP monoclonal antibody (mAb) 44B1, pentosan polysulfate (PPS), chlorpromazine (CPZ) and U18666A on the intracellular dynamics of a cellular isoform of prion protein (PrP(C)) and PrP(Sc) in prion-infected mouse neuroblastoma cells to re-evaluate the effects of those agents. MAb 44B1 and PPS rapidly reduced PrP(Sc) levels without altering intracellular distribution of PrP(Sc). PPS did not change the distribution and levels of PrP(C), whereas mAb 44B1 appeared to inhibit the trafficking of cell surface PrP(C) to organelles in the endocytic-recycling pathway that are thought to be one of the sites for PrP(Sc) formation. In contrast, CPZ and U18666A initiated the redistribution of PrP(Sc) from organelles in the endocytic-recycling pathway to late endosomes/lysosomes without apparent changes in the distribution of PrP(C). The inhibition of lysosomal function by monensin or bafilomycin A1 after the occurrence of PrP(Sc) redistribution by CPZ or U18666A partly antagonized PrP(Sc) degradation, suggesting that the transfer of PrP(Sc) to late endosomes/lysosomes, possibly via alteration of the membrane trafficking machinery of cells, leads to PrP(Sc) degradation. This study revealed that precise analysis of the intracellular dynamics of PrP(C) and PrP(Sc) provides important information for understanding the mechanism of anti-prion agents. PMID:25181483

  17. 21 CFR 522.1850 - Polysulfated glycosaminoglycan.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Polysulfated glycosaminoglycan. 522.1850 Section 522.1850 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS IMPLANTATION OR INJECTABLE DOSAGE FORM NEW ANIMAL...

  18. Inhibitory effect of polysulfated heparin endostatin on alkali burn induced corneal neovascularization in rabbits

    PubMed Central

    Li, Zhao-Na; Yuan, Zhong-Fang; Mu, Guo-Ying; Hu, Ming; Cao, Li-Jun; Zhang, Ya-Li; Liu, Lei; Ge, Ming-Xu

    2015-01-01

    AIM To investigate anti-angiogenic effects of polysulfated heparin endostatin (PSH-ES) on alkali burn induced corneal neovascularization (NV) in rabbits. METHODS An alkali burn was made on rabbit corneas to induce corneal NV in the right eye of 24 rabbits. One day after burn creation, a 0.2 mL subconjunctival injection of 50 µg/mL PSH-ES, 50 µg/mL recombinant endostatin (ES), or normal saline was administered every other day for a total of 14d (7 injections). Histology and immunohistochemisty were used to examine corneas. Corneal NV growth was evaluated as microvessel quantity and corneal vascular endothelial growth factor (VEGF) expression was measured by immunohistochemical assay. RESULTS Subconjunctival injection of ES and PSH-ES resulted in significant corneal NV suppression, but PSH-ES had a more powerful anti-angiogenic effect than ES. Mean VEGF concentration in PSH-ES treated corneas was significantly lower than in ES treated and saline treated corneas. Histological examination showed that corneas treated with either PSH-ES or ES had significantly fewer microvessels than eyes treated with saline. Additionally corneas treated with PSH-ES had significantly fewer microvessels than corneas treated with ES. CONCLUSION Both PSH-ES and recombinant ES effectively inhibit corneal NV induced by alkali burn. However, PSH-ES is a more powerful anti-angiogenic agent than ES. This research has the potential to provide a new treatment option for preventing and treating corneal NV. PMID:25938033

  19. Polysulfated Trehalose as a Novel Anticoagulant Agent with Dual Mode of Action

    PubMed Central

    Rashid, Qudsia; Abid, Mohammad; Gupta, Neha; Tyagi, Tarun; Ashraf, Mohammad Z.; Jairajpuri, Mohamad Aman

    2015-01-01

    Physiological hemostatic balance is a coordinated outcome of counteracting coagulation and fibrinolytic systems. An imbalance of procoagulant and anticoagulant factors may result in life threatening thromboembolism. Presently, anticoagulant administration is the first line of therapy for the treatment of these conditions and several anticoagulants have been approved, including various forms of heparin. However, the polyanionic nature and multispecificity of heparin pose several complications. Generally, the polysulfated compounds with antithrombotic potential are thought to have feasible synthetic procedures with much less bleeding, thus having favourable safety profiles. Here we report the synthesis of a novel compound, trehalose octasulfate and the assessment of its anticoagulation potential. Molecular docking of trehalose and trehalose octasulfate with antithrombin showed a specificity switch in binding affinity on sulfation, where trehalose octasulfate interacts with critical residues of AT that are either directly involved in heparin binding or in the conformational rearrangement of AT on heparin binding. An in vitro analysis of trehalose octasulfate demonstrated prolonged clotting time. Lead compound when intravenously injected in occlusion induced thrombotic rats showed remarkable reduction in the size and weight of the clot at a low dose. Delay in coagulation time was observed by analysing blood plasma isolated from rats preinjected with trehalose octasulfate. A decrease in Adenosine 5′-Diphosphate (ADP) induced platelet aggregation indicated a probable dual anticoagulant and antiplatelet mechanism of action. To summarize, this study presents trehalose octasulfate as a novel, effective, dual acting antithrombotic agent. PMID:25866798

  20. Energy utilization and growth performance of chickens fed novel wheat inbred lines selected for different pentosan levels with and without xylanase supplementation.

    PubMed

    Pirgozliev, V; Rose, S P; Pellny, T; Amerah, A M; Wickramasinghe, M; Ulker, M; Rakszegi, M; Bedo, Z; Shewry, P R; Lovegrove, A

    2015-02-01

    Different F5 recombinant inbred lines from the cross Yumai 34×Ukrainka were grown in replicated trials on a single site in one harvest year at Rothamsted Research. A total of 10 samples from those lines were harvested and used in a broiler experiment. Twenty nutritionally complete meal-form diets that had 630 g/kg of wheat with different amounts of pentosan, with and without exogenous xylanase supplementation, were used to compare broiler growth performance and determine apparent metabolizable energy corrected for N retention (AMEn). We examined the relationship between the nutritive value of the wheat samples and their chemical compositions and results of quality tests. The amounts of total and water soluble pentosans in wheat samples ranged from 36.7 to 48.0 g/kg DM, and 6.7 to 11.6 g/kg DM, respectively. The mean crude oil and protein contents of the wheat samples were 10.5 and 143.9 g/kg DM, respectively. The average determined value for the kinematic viscosity was 0.0018 mPa.s, and 2.1 mPa.s for the dynamic viscosity. The AMEn of the wheat-based diets had a maximum range of 0.47 MJ/kg DM within the ten wheat samples that were tested. Xylanase supplementation improved (P<0.05) dietary AMEn, dry matter, and fat digestibility coefficients. There was a positive (P<0.05) relationship between in vitro kinematic viscosity of the wheat samples and the total pentosan content. There was a negative relationship between the total pentosan content in the wheat and broiler growth performance. An increase by 10 g of pentosan per kg of wheat reduced (P<0.001) daily feed intake and weight gain by 2.9 g and 3.5 g, respectively. The study shows that the feeding quality of wheat samples can be predicted by their total pentosan content. Supplementary xylanase improved energy and nutrient availability of all wheat samples that was independent of differences in pentosan content. PMID:25595480

  1. Energy utilization and growth performance of chickens fed novel wheat inbred lines selected for different pentosan levels with and without xylanase supplementation

    PubMed Central

    Pirgozliev, V.; Rose, S. P.; Pellny, T.; Amerah, A. M.; Wickramasinghe, M.; Ulker, M.; Rakszegi, M.; Bedo, Z.; Shewry, P. R.; Lovegrove, A.

    2015-01-01

    Different F5 recombinant inbred lines from the cross Yumai 34 × Ukrainka were grown in replicated trials on a single site in one harvest year at Rothamsted Research. A total of 10 samples from those lines were harvested and used in a broiler experiment. Twenty nutritionally complete meal-form diets that had 630 g/kg of wheat with different amounts of pentosan, with and without exogenous xylanase supplementation, were used to compare broiler growth performance and determine apparent metabolizable energy corrected for N retention (AMEn). We examined the relationship between the nutritive value of the wheat samples and their chemical compositions and results of quality tests. The amounts of total and water soluble pentosans in wheat samples ranged from 36.7 to 48.0 g/kg DM, and 6.7 to 11.6 g/kg DM, respectively. The mean crude oil and protein contents of the wheat samples were 10.5 and 143.9 g/kg DM, respectively. The average determined value for the kinematic viscosity was 0.0018 mPa.s, and 2.1 mPa.s for the dynamic viscosity. The AMEn of the wheat-based diets had a maximum range of 0.47 MJ/kg DM within the ten wheat samples that were tested. Xylanase supplementation improved (P < 0.05) dietary AMEn, dry matter, and fat digestibility coefficients. There was a positive (P < 0.05) relationship between in vitro kinematic viscosity of the wheat samples and the total pentosan content. There was a negative relationship between the total pentosan content in the wheat and broiler growth performance. An increase by 10 g of pentosan per kg of wheat reduced (P < 0.001) daily feed intake and weight gain by 2.9 g and 3.5 g, respectively. The study shows that the feeding quality of wheat samples can be predicted by their total pentosan content. Supplementary xylanase improved energy and nutrient availability of all wheat samples that was independent of differences in pentosan content. PMID:25595480

  2. Effect of pentosans addition on pasting properties of flours of eight hard white spring wheat cultivars.

    PubMed

    Arif, Saqib; Ali, Tahira Mohsin; Ul Afzal, Qurat; Ahmed, Mubarik; Siddiqui, Asim Jamal; Hasnain, Abid

    2014-06-01

    The effects of water extractable pentosans (WEP) and water unextractable pentosans (WUP) on pasting properties in flours of eight different hard white spring wheat (HWSW) cultivars was studied. WEP and WUP isolated from a hard wheat flour were added to each of the cultivars at 1% and 2% level. The results indicated that WEP exhibited a pronounced effect on pasting properties as compared to WUP and variety. Univariate analysis of variance (ANOVA) was used to evaluate sources of variation. The variety significantly (P < 0.001) influenced all the pasting parameters. WUP caused significant (P < 0.001) variation in paste viscosities (except breakdown). WEP influenced more pronouncedly the hot paste, cold paste, breakdown and setback viscosities with F values-221.802, 214.286, 98.073 and 120.159, respectively. Variety-by-WEP interaction exhibited significant (P < 0.01) influence on pasting time, peak, hot paste and cold paste viscosities. Whereas, variety-by-WUP interaction only significantly (P < 0.001) influenced the pasting- time and -temperature. Duncan's test was used to analyze the significant difference (P < 0.05) within the variety. The results revealed that WUP did not induce significant (P < 0.05) influence on all the pasting parameters, whereas, WEP influenced significantly (P < 0.05) the paste viscosities of some of the varieties. It was also found that the addition of WEP remarkably reduced the setback, hot paste, cold paste viscosities and increased the breakdown viscosity in all cultivar flours. The effect of WEP was greater at higher level of supplementation on paste viscosities. PMID:24876638

  3. Effects of Low Level Water-soluble Pentosans, Alkaline-extractable Pentosans, and Xylanase on the Growth and Development of Broiler Chicks

    PubMed Central

    Sheng, Q. K.; Yang, L. Q.; Zhao, H. B.; Wang, X. L.; Wang, K.

    2013-01-01

    This study investigated the effects of low levels of water-soluble pentosans (WSP), alkaline-extractable pentosans (AEP), and xylanase on the growth and organ development of broiler chicks. Three hundred and fifty 1-d-old female broiler chicks were randomly allocated into seven experimental groups of five pen replicates, with ten chicks per replicate. The control group consumed a corn-soybean meal-based diet. Six dietary treatment groups consumed the basal diet supplemented with one of the following: WSP at 50 mg/kg (WSP50) or 100 mg/kg (WSP100); AEP at 50 mg/kg (AEP50) or 100 mg/kg (AEP100); or xylanase at 3 mg/kg (Xase3) or 6 mg/kg (Xase6). Data including the body weight, digestive organ weights, gut length, rectal digesta viscosity, and gut microflora and pH were collected on d 5, 10, and 15. When compared to the control group, WSP50 promoted body weight gain and organ growth throughout the study, calculated as 3-d averages (p<0.05). WSP100 increased weight gain and enhanced organ development (proventriculus, gizzard, and gut) on d 10 (p<0.05), but the 3-d averages were not different from the control group except for the weight of gizzard. Both Xase3 and Xase6 increased the 3-d average weight gain and the growth of the gizzard (p<0.05). WSP50 increased the digesta viscosity compared to Xase3 on d 10 and 15 (p<0.05). WSP50, Xase3, and Xase6 increased the concentration of Lactobacillus in the rectum when compared to the control group (p<0.05), but only Xase3 lowered the digesta pH in the ileum and cecum on d 10 and 15. AEP had minimal influence on the growth and organ development of broilers. The results showed that low levels of WSP, AEP, and xylanase had different effects and underlying mechanisms on the growth and organ development of broiler chicks. WSP50 could increase the growth performance of broilers fed a corn-soybean meal-based diet. PMID:25049914

  4. Effects of intramuscular administration of glycosaminoglycan polysulfates on signs of incipient hip dysplasia in growing pups.

    PubMed

    Lust, G; Williams, A J; Burton-Wurster, N; Beck, K A; Rubin, G

    1992-10-01

    We tested the hypothesis that treatment of growing, susceptible (to hip dysplasia) pups by IM administration of glycosaminoglycan polysulfates would mitigate the signs of incipient hip dysplasia. In 1 experiment, 7 pups, selected at random from 2 litters, were administered glycosaminoglycan polysulfates (2.5 mg/kg of body weight, IM) twice weekly, and 7 control pups from the same litters were given sterile buffered 0.9% saline solution from the age of 6 weeks to 8 months. Hip joints were examined by radiography, with pups in the standard, limbs-extended position. At 8 months of age, all pups in this experiment did not manifest femoral head subluxation radiographically. The Norberg angle, a measure of coxofemoral congruity, improved from a mean +/- SEM value of 102 degrees +/- 1 degrees in controls to 106 degrees +/- 1 degrees in treated pups (P = 0.008). Pups were not subjected to necropsy. In the second experiment, 8 pups were selected at random from 2 litters and were administered 5 mg of glycosaminoglycan polysulfates/kg, IM, twice weekly from 6 weeks to 8 months of age. Similarly, 8 control pups were administered saline solution. At 8 months of age, hip joints were examined by radiography with pups in the standard position; at necropsy, intra-articular tissues were evaluated macroscopically and biochemically. Of 8 treated pups, none had subluxation radiographically, whereas 4 of 8 control dogs had femoral head subluxation. Mean Norberg angle on the radiographs was 109.7 degrees +/- 1.6 degrees for the treated group and was 101.5 degrees +/- 1.6 degrees for controls, representing a mean improvement in coxofemoral congruity of 8.2 degrees in the treated pups.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:1456530

  5. Augmented anti-angiogenesis activity of polysulfated heparin-endostatin and polyethylene glycol-endostatin in alkali burn-induced corneal ulcers in rabbits

    PubMed Central

    LI, ZHAO-NA; YUAN, ZHONG-FANG; MU, GUO-YING; HU, MING; CAO, LI-JUN; ZHANG, YA-LI; GE, MING-XU

    2015-01-01

    Endostatin (ES) is an endogenous angiogenesis inhibitor that has the ability to inhibit tumor growth and metastasis. However, its clinical application is limited by a number of disadvantages, such as poor stability, short half-life and the requirement of high doses to maintain its efficacy. The chemical modification on ES may offer a solution to these disadvantages. The aim of the present study was to evaluate the effects of ES, polysulfated heparin-endostatin (PSH-ES) and polyethylene glycol-endostatin (PEG-ES) on the endothelial cell proliferation and angiogenesis associated with corneal neovascularization (CNV) and to determine their mechanisms of action. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) was used to study the effects of ES and its derivatives on endothelial cell proliferation in vitro, and rabbits were used to evaluate the effects of ES and its derivatives on CNV in vivo. In the evaluation of CNV, the expression of vascular endothelial growth factor in the cornea was measured via immunohistochemistry and microvessels were counted. ES and its derivatives significantly inhibited endothelial cell proliferation in vitro (P<0.05) and suppressed CNV in vivo. Among the compounds examined, ES most effectively inhibited endothelial cell proliferation in vitro (P<0.05); however, PSH-ES and PEG-ES most effectively inhibited CNV in vivo (P<0.05). These results indicate that PSH-ES and PEG-ES are candidate anti-angiogenesis drugs. PMID:26622410

  6. Pentosan-derived water-soluble carbon nano dots with substantial fluorescence: Properties and application as a photosensitizer

    NASA Astrophysics Data System (ADS)

    Wu, Qiong; Li, Wei; Wu, Yanjiao; Huang, Zhanhua; Liu, Shouxin

    2014-10-01

    The hydrothermal carbonization of monosaccharides and polysaccharides is widely used in the production of carbonaceous material with a desired structure. However, the liquid products are regarded as waste and discarded. Here, we report a facile approach for the synthesis of water-soluble carbon nano dots (CNDs) with substantial fluorescence from the liquid by-products of the hydrothermal carbonization of pentosan, thus the by-products of pulp refining. The synthesized CNDs are monodispersed spheres with abundant oxygen-containing groups and they have an average size of 30 nm. Quantum yield measurements revealed CNDs with substantial green photoluminescence (PL) without passivation. Additionally, excitation was independent, pH-sensitive and stable. The use of CNDs as a photosensitizer in the CNDs/TiO2 system for methylene blue (MB) degradation under visible light irradiation is attractive. The spectral response range of the CNDs/TiO2 system can be widened from the UV region to a part of the visible light region (400-550 nm).

  7. In vitro hemorheological effects of parenteral agents used in peripheral arterial disease

    NASA Astrophysics Data System (ADS)

    Biro, Katalin; Sandor, Barbara; Toth, Andras; Koltai, Katalin; Papp, Judit; Rabai, Miklos; Toth, Kalman; Kesmarky, Gabor

    2014-05-01

    Peripheral arterial disease (PAD) is a frequent manifestation of systemic atherosclerosis. In PAD hemorheological parameters were defined as risk factors in a number of studies and several therapeutic agents were tried in these conditions. Our study aims to investigate and compare the in vitro hemorheological effects of various drugs generally used in the parenteral treatment of intermittent claudication and critical limb ischemia. Blood samples of healthy male volunteers were incubated with iloprost, alprostadil, pentoxifylline, sulodexide or pentosan polysulfate at calculated therapeutic serum concentration. Hematocrit (Hct) was determined by microhematocrit centrifuge. Plasma and apparent whole blood viscosities (WBV) were evaluated by capillary viscometer. Red blood cell aggregation was measured by LORCA (laserassisted optical rotational cell analyzer) aggregometer, and LORCA ektacytometer was used for measuring erythrocyte deformability at 37°C. Iloprost, alprostadil, and pentoxifylline incubation did not have any significant effect on plasma and apparent WBV. Elongation index increased in samples incubated with alprostadil at low shear stresses 0.95 and 0.53 Pa (p < 0.05). Sulodexide significantly improved WBV and Hct/WBV ratio (p < 0.05). Incubation with pentosan polysulfate resulted in higher WBV, lower Hct/WBV ratio and deterioration in the aggregation parameters (p < 0.05). Sulodexide may have beneficial effect on a macrorheological parameter; alprostadil may improve a microrheological parameter. Hemorheological alterations could be important in PAD patients with hampered vasodilator capacity.

  8. Results.

    ERIC Educational Resources Information Center

    Zemsky, Robert; Shaman, Susan; Shapiro, Daniel B.

    2001-01-01

    Describes the Collegiate Results Instrument (CRI), which measures a range of collegiate outcomes for alumni 6 years after graduation. The CRI was designed to target alumni from institutions across market segments and assess their values, abilities, work skills, occupations, and pursuit of lifelong learning. (EV)

  9. Therapies for human prion diseases

    PubMed Central

    Panegyres, Peter K; Armari, Elizabeth

    2013-01-01

    The pathological foundation of human prion diseases is a result of the conversion of the physiological form of prion protein (PrPc) to the pathological protease resistance form PrPres. Most patients with prion disease have unknown reasons for this conversion and the subsequent development of a devastating neurodegenerative disorder. The conversion of PrPc to PrPres, with resultant propagation and accumulation results in neuronal death and amyloidogenesis. However, with increasing understanding of neurodegenerative processes it appears that protein-misfolding and subsequent propagation of these rouge proteins, is a generic phenomenon shared with diseases caused by tau, α-synucleins and β-amyloid proteins. Consequently, effective anti-prion agents may have wider implications. A number of therapeutic approaches include polyanionic, polycyclic drugs such as pentosan polysulfate (PPS), which prevent the conversion of PrPc to PrPres and might also sequester and down-regulate PrPres. Polyanionic compounds might also help to clear PrPres. Treatments aimed at the laminin receptor, which is an important accessory molecule in the conversion of PrPc to PrPres – neuroprotection, immunotherapy, siRNA and antisense approaches have provided some experimental promise. PMID:24093082

  10. Hemorrhagic radiation cystitis.

    PubMed

    Mendenhall, William M; Henderson, Randal H; Costa, Joseph A; Hoppe, Bradford S; Dagan, Roi; Bryant, Curtis M; Nichols, Romaine C; Williams, Christopher R; Harris, Stephanie E; Mendenhall, Nancy P

    2015-06-01

    The optimal management of persistent hemorrhagic radiation cystitis is ill-defined. Various options are available and include oral agents (ie, sodium pentosan polysulfate), intravenous drugs (ie, WF10), topical agents (ie, formalin), hyperbaric oxygen, and endoscopic procedures (ie, electrical cautery, argon plasma coagulation, laser coagulation). In general, it is best to manage patients conservatively and intervene only when necessary with the option least likely to exacerbate the cystitis. More aggressive measures should be employed only when more conservative approaches fail. Bladder biopsies should be avoided, unless findings suggest a bladder tumor, because they may precipitate a complication. PMID:24322335

  11. Prion diseases: immunotargets and therapy

    PubMed Central

    Burchell, Jennifer T; Panegyres, Peter K

    2016-01-01

    Transmissible spongiform encephathalopathies or prion diseases are a group of neurological disorders characterized by neuronal loss, spongiform degeneration, and activation of astrocytes or microglia. These diseases affect humans and animals with an extremely high prevalence in some species such as deer and elk in North America. Although rare in humans, they result in a devastatingly swift neurological progression with dementia and ataxia. Patients usually die within a year of diagnosis. Prion diseases are familial, sporadic, iatrogenic, or transmissible. Human prion diseases include Kuru, sporadic, iatrogenic, and familial forms of Creutzfeldt–Jakob disease, variant Creutzfeldt–Jakob disease, Gerstmann–Sträussler–Scheinker disease, and fatal familial insomnia. The causative agent is a misfolded version of the physiological prion protein called PrPSc in the brain. There are a number of therapeutic options currently under investigation. A number of small molecules have had some success in delaying disease progression in animal models and mixed results in clinical trials, including pentosan polysulfate, quinacrine, and amphotericin B. More promisingly, immunotherapy has reported success in vitro and in vivo in animal studies and clinical trials. The three main branches of immunotherapy research are focus on antibody vaccines, dendritic cell vaccines, and adoptive transfer of physiological prion protein-specific CD4+ T-lymphocytes. Vaccines utilizing antibodies generally target disease-specific epitopes that are only exposed in the misfolded PrPSc conformation. Vaccines utilizing antigen-loaded dendritic cell have the ability to bypass immune tolerance and prime CD4+ cells to initiate an immune response. Adoptive transfer of CD4+ T-cells is another promising target as this cell type can orchestrate the adaptive immune response. Although more research into mechanisms and safety is required, these immunotherapies offer novel therapeutic targets for prion

  12. Prion diseases: immunotargets and therapy.

    PubMed

    Burchell, Jennifer T; Panegyres, Peter K

    2016-01-01

    Transmissible spongiform encephathalopathies or prion diseases are a group of neurological disorders characterized by neuronal loss, spongiform degeneration, and activation of astrocytes or microglia. These diseases affect humans and animals with an extremely high prevalence in some species such as deer and elk in North America. Although rare in humans, they result in a devastatingly swift neurological progression with dementia and ataxia. Patients usually die within a year of diagnosis. Prion diseases are familial, sporadic, iatrogenic, or transmissible. Human prion diseases include Kuru, sporadic, iatrogenic, and familial forms of Creutzfeldt-Jakob disease, variant Creutzfeldt-Jakob disease, Gerstmann-Sträussler-Scheinker disease, and fatal familial insomnia. The causative agent is a misfolded version of the physiological prion protein called PrP(Sc) in the brain. There are a number of therapeutic options currently under investigation. A number of small molecules have had some success in delaying disease progression in animal models and mixed results in clinical trials, including pentosan polysulfate, quinacrine, and amphotericin B. More promisingly, immunotherapy has reported success in vitro and in vivo in animal studies and clinical trials. The three main branches of immunotherapy research are focus on antibody vaccines, dendritic cell vaccines, and adoptive transfer of physiological prion protein-specific CD4(+) T-lymphocytes. Vaccines utilizing antibodies generally target disease-specific epitopes that are only exposed in the misfolded PrP(Sc) conformation. Vaccines utilizing antigen-loaded dendritic cell have the ability to bypass immune tolerance and prime CD4(+) cells to initiate an immune response. Adoptive transfer of CD4(+) T-cells is another promising target as this cell type can orchestrate the adaptive immune response. Although more research into mechanisms and safety is required, these immunotherapies offer novel therapeutic targets for prion

  13. Interstitial Cystitis: Characterization and Management of an Enigmatic Urologic Syndrome

    PubMed Central

    Nickel, J. Curtis

    2002-01-01

    The enigmatic urologic condition known as interstitial cystitis has an estimated prevalence of 0.01% to 0.50% of the female population. Its etiology is unknown but may involve microbiologic, immunologic, mucosal, neurogenic, and/or other, as yet undefined, agents. There is no gold standard for the diagnosis of interstitial cystitis; rather, it is a diagnosis of exclusion. It is impossible to provide a purely evidence-based treatment strategy, but review of available evidence suggests that conservative supportive therapy (including diet modification); oral treatment with pentosan polysulfate, amitriptyline, hydroxyzine, or cimetidine; and intravesical treatments with heparinoids, dimethyl sulfoxide, alkalized lidocaine, or bacille Calmette-Guérin may be effective in some patients. PMID:16985667

  14. Research Results

    NASA Astrophysics Data System (ADS)

    2011-12-01

    Research on Global Carbon Emission and Sequestration NSFC Funded Project Made Significant Progress in Quantum Dynamics Functional Human Blood Protein Obtained from Rice How Giant Pandas Thrive on a Bamboo Diet New Evidence of Interpersonal Violence from 129,000 Years Ago Found in China Aptamer-Mediated Efficient Capture and Release of T Lymphocytes on Nanostructured Surfaces BGI Study Results on Resequencing 50 Accessions of Rice Cast New Light on Molecular Breeding BGI Reports Study Results on Frequent Mutation of Genes Encoding UMPP Components in Kidney Cancer Research on Habitat Shift Promoting Species Diversification

  15. DONUT results

    SciTech Connect

    Furukawa, Tomoko

    2008-02-21

    The DONUT experiment succeeded in observing tau-neutrino CC interactions for the first time in 2000. The analysis using total sample is presented in this paper, based on 3.5x10{sup 17} protons on target. The number of identified {nu}{sub {tau}} CC interactions is 9 from 581 neutrino interactions located in the emulsion. The result of the first measurement of {nu}{sub {tau}} CC cross section is consistent with the expectation from the Standard Model.

  16. Inflammatory Kinetics and Efficacy of Anti-inflammatory Treatments on Human Nucleus Pulposus Cells

    PubMed Central

    Walter, Benjamin A; Purmessur, Devina; Likhitpanichkul, Morakot; Weinberg, Alan; Cho, Samuel K.; Qureshi, Sheeraz A.; Hecht, Andrew C.; Iatridis, James C.

    2015-01-01

    Study Design Human nucleus pulposus (NP) cell culture study investigating response to tumor necrosis factor-α (TNFα), effectiveness of clinically available anti-inflammatory drugs, and interactions between pro-inflammatory cytokines. Objective To characterize the kinetic response of pro-inflammatory cytokines released by human NP cells to TNFα stimulation and the effectiveness of multiple anti-inflammatories with 3 sub-studies: Timecourse, Same-time blocking, Delayed blocking. Summary of Background Data Chronic inflammation is a key component of painful intervertebral disc (IVD) degeneration. Improved efficacy of anti-inflammatories requires better understanding of how quickly NP cells produce pro-inflammatory cytokines and which pro-inflammatory mediators are most therapeutically advantageous to target. Methods Degenerated human NP cells (n=10) were cultured in alginate with or without TNFα (10ng/mL). Cells were incubated with one of four anti-inflammatories (anti-IL-6 receptor/atlizumab, IL-1 receptor anatagonist, anti-TNFα/infliximab and sodium pentosan polysulfate/PPS) in two blocking-studies designed to determine how intervention timing influences drug efficacy. Cell viability, protein and gene expression for IL-1β, IL-6 & IL-8 were assessed. Results Timecourse: TNFα substantially increased the amount of IL-6, IL-8 & IL-1β, with IL-1β and IL-8 reaching equilibrium within ~72 hours (IL-1β: 111±40pg/mL, IL-8: 8478±957pg/mL), and IL-6 not reaching steady state after 144 hours (1570±435 pg/mL). Anti-TNFα treatment was most effective at reducing the expression of all cytokines measured when added at the same time as TNFα stimulation. Similar trends were observed when drugs were added 72 hours after TNFα stimulation, however, no anti-inflammatories significantly reduced cytokine levels compared to TNF control. Conclusion IL-1β, IL-6 and IL-8 were expressed at different rates and magnitudes suggesting different roles for these cytokines in disease

  17. Mechanisms Involved in the Anti-Inflammatory Action of a Polysulfated Fraction from Gracilaria cornea in Rats

    PubMed Central

    Coura, Chistiane Oliveira; Souza, Ricardo Basto; Rodrigues, José Ariévilo Gurgel; Vanderlei, Edfranck de Sousa Oliveira; de Araújo, Ianna Wivianne Fernandes; Ribeiro, Natássia Albuquerque; Frota, Annyta Fernandes; Ribeiro, Kátia Alves; Chaves, Hellíada Vasconcelos; Pereira, Karuza Maria Alves; da Cunha, Rodrigo Maranguape Silva; Bezerra, Mirna Marques; Benevides, Norma Maria Barros

    2015-01-01

    The anti-inflammatory mechanisms of the sulfated polysaccharidic fraction obtained from red marine alga Gracilaria cornea (Gc-FI) were investigated using a paw edema model induced in rats by different inflammatory agents (carrageenan, dextran, serotonin, bradykinin, compound 48/80 or L-arginine). Gc-FI at the doses of 3, 9 or 27 mg/kg, subcutaneously - s.c., significantly inhibited rat paw edema induced by carrageenan and dextran, as confirmed by myeloperoxidase and Evans’ blue assessments, respectively. Gc-FI (9 mg/kg, s.c.) inhibited rat paw edema induced by histamine, compound 48/80 and L-arginine. Additionally, Gc-FI (9 mg/kg, s.c.) inhibited Cg-induced edema in animals with intact mast cells but did not inhibit that with degranulated mast cells by compound 48/80, revealing a protective role on mast cell membranes. Gc-FI down-regulated the IL-1β, TNF-α and COX-2 mRNA and protein levels compared with those of the carrageenan group, based on qRT-PCR and immunohistochemistry analyses. After inhibition with ZnPP IX, a specific heme oxygenase-1 (HO-1) inhibitor, the anti-inflammatory effect of Gc-FI was not observed in Cg-induced paw edema, suggesting that the anti-inflammatory effect of Gc-FI is, in part, dependent on the integrity of the HO-1 pathway. Gc-FI can target a combination of multiple points involved in inflammatory phenomena. PMID:25807556

  18. Mass balance of pilot-scale pretreatment of sugarcane bagasse by steam explosion followed by alkaline delignification.

    PubMed

    Rocha, George J M; Martín, Carlos; da Silva, Vinícius F N; Gómez, Edgardo O; Gonçalves, Adilson R

    2012-05-01

    Five pilot-scale steam explosion pretreatments of sugarcane bagasse followed by alkaline delignification were explored. The solubilised lignin was precipitated with 98% sulphuric acid. Most of the pentosan (82.6%), and the acetyl group fractions were solubilised during pretreatment, while 90.2% of cellulose and 87.0% lignin were recovered in the solid fraction. Approximately 91% of the lignin and 72.5% of the pentosans contained in the steam-exploded solids were solubilised by delignification, resulting in a pulp with almost 90% of cellulose. The acidification of the black liquors allowed recovery of 48.3% of the lignin contained in the raw material. Around 14% of lignin, 22% of cellulose and 26% of pentosans were lost during the process. In order to increase material recovery, major changes, such as introduction of efficient condensers and the reduction in the number of washing steps, should be done in the process setup. PMID:22391588

  19. Trans-repressor activity of nuclear glycosaminoglycans on Fos and Jun/AP-1 oncoprotein-mediated transcription.

    PubMed

    Busch, S J; Martin, G A; Barnhart, R L; Mano, M; Cardin, A D; Jackson, R L

    1992-01-01

    Heparin blocks the phorbol ester-induced progression of nontransformed cells through the G0/G1 phase (Wright, T.C., L.A. Pukac, J.J. Castellot, M.J. Karnovsky, R.A. Levine, H.-Y. Kim-Park, and J. Campisi. 1989. Proc. Natl. Acad. Sci. USA. 86: 3199-3203) or G1 to S phase (Reilly, C. F., M. S. Kindy, K. E. Brown, R. D. Rosenberg, and G. E Sonenshein. 1989. J. Biol. Chem. 264:6990-6995) of the cell cycle. Cell cycle arrest was associated with decreased levels of stage-specific mRNAs suggesting transcriptional regulation of cell growth. In the present report, we show that heparin selectively repressed TPA-inducible AP-1-mediated gene expression. Heparin-induced trans-repression was observed in primary vascular smooth muscle cells, as well as in the transformed HeLa cell line and in nondifferentiated F9 teratocarcinoma cells. Inhibition of AP-1-mediated trans-activation occurred with heparin and pentosan polysulfate but not with chondroitin sulfate A or C. Heparin-binding peptides or heparitinase I addition to nuclear lysates of heparin-treated cells allowed enhanced recovery of endogenous AP-1-specific DNA binding activity. We propose a model in which nuclear glycosaminoglycans play a trans-regulatory role in altering the patterns of inducible gene expression. PMID:1730747

  20. Derivation of Mesenchymal Stromal Cells from Canine Induced Pluripotent Stem Cells by Inhibition of the TGFβ/Activin Signaling Pathway

    PubMed Central

    Frith, Jessica E.; Frith, Thomas J.R.; Ovchinnikov, Dmitry A.; Cooper-White, Justin J.; Wolvetang, Ernst J.

    2014-01-01

    In this study we have generated canine mesenchymal stromal cells (MSCs), also known as mesenchymal stem cells, from canine induced pluripotent stem cells (ciPSCs) by small-molecule inhibition of the transforming growth factor beta (TGFβ)/activin signaling pathway. These ciPSC-derived MSCs (ciPSC-MSCs) express the MSC markers CD73, CD90, CD105, STRO1, cPDGFRβ and cKDR, in addition to the pluripotency factors OCT4, NANOG and REX1. ciPSC-MSCs lack immunostaining for H3K27me3, suggesting that they possess two active X chromosomes. ciPSC-MSCs are highly proliferative and undergo robust differentiation along the osteo-, chondro- and adipogenic pathways, but do not form teratoma-like tissues in vitro. Of further significance for the translational potential of ciPSC-MSCs, we show that these cells can be encapsulated and maintained within injectable hydrogel matrices that, when functionalized with bound pentosan polysulfate, dramatically enhance chondrogenesis and inhibit osteogenesis. The ability to efficiently derive large numbers of highly proliferative canine MSCs from ciPSCs that can be incorporated into injectable, functionalized hydrogels that enhance their differentiation along a desired lineage constitutes an important milestone towards developing an effective MSC-based therapy for osteoarthritis in dogs, but equally provides a model system for assessing the efficacy and safety of analogous approaches for treating human degenerative joint diseases. PMID:25055193

  1. Characteristics of Mitochondrial Transformation into Human Cells

    PubMed Central

    Kesner, E. E.; Saada-Reich, A.; Lorberboum-Galski, H.

    2016-01-01

    Mitochondria can be incorporated into mammalian cells by simple co-incubation of isolated mitochondria with cells, without the need of transfection reagents or any other type of intervention. This phenomenon was termed mitochondrial transformation, and although it was discovered in 1982, currently little is known regarding its mechanism(s). Here we demonstrate that mitochondria can be transformed into recipient cells very quickly, and co-localize with endogenous mitochondria. The isolated mitochondria interact directly with cells, which engulf the mitochondria with cellular extensions in a way, which may suggest the involvement of macropinocytosis or macropinocytosis-like mechanisms in mitochondrial transformation. Indeed, macropinocytosis inhibitors but not clathrin-mediated endocytosis inhibition-treatments, blocks mitochondria transformation. The integrity of the mitochondrial outer membrane and its proteins is essential for the transformation of the mitochondria into cells; cells can distinguish mitochondria from similar particles and transform only intact mitochondria. Mitochondrial transformation is blocked in the presence of the heparan sulfate molecules pentosan polysulfate and heparin, which indicate crucial involvement of cellular heparan sulfate proteoglycans in the mitochondrial transformation process. PMID:27184109

  2. Interstitial cystitis. Etiology, diagnosis, and treatment.

    PubMed Central

    Nickel, J. C.

    2000-01-01

    OBJECTIVE: To review current knowledge about the epidemiology, etiology, diagnosis, and treatment of interstitial cystitis, with special emphasis on management of this condition by family physicians. QUALITY OF EVIDENCE: Articles were identified through MEDLINE and review of abstracts presented at Urology and Interstitial Cystitis meetings during the last decade. Recent reviews were further searched for additional studies and trials. Data were summarized from large epidemiologic studies. Etiologic theories were extracted from current concepts and reviews of scientific studies. Diagnostic criteria described in this review are based on clinical interpretation of National Institutes of Health (NIH) research guidelines, interpretation of data from the NIH Interstitial Cystitis Cohort Study, and recent evidence on use of the potassium sensitivity test. Treatment suggestions are based on six randomized placebo-controlled clinical treatment trials and best available clinical data. MAIN MESSAGE: Interstitial cystitis affects about 0.01% to 0.5% of women. Its etiology is unknown, but might involve microbiologic, immunologic, mucosal, neurogenic, and other yet undefined agents. The diagnosis of interstitial cystitis is a diagnosis of exclusion. It is impossible to provide a purely evidence-based treatment strategy, but review of available evidence suggests that conservative supportive therapy (including diet modification); oral treatment with pentosan polysulfate, amitriptyline, or hydroxyzine; and intravesical treatments with heparinlike medications, dimethyl sulfoxide, or BCG vaccine could benefit some patients. CONCLUSION: Family physicians should have an understanding of interstitial cystitis and be able to make a diagnosis and formulate an evidence-based treatment strategy for their patients. PMID:11153410

  3. Intra-articular therapy in osteoarthritis

    PubMed Central

    Uthman, I; Raynauld, J; Haraoui, B

    2003-01-01

    The medical literature was reviewed from 1968–2002 using Medline and the key words "intra-articular" and "osteoarthritis" to determine the various intra-articular therapies used in the treatment of osteoarthritis. Corticosteroids and hyaluronic acid are the most frequently used intra-articular therapies in osteoarthritis. Other intra-articular substances such as orgotein, radiation synovectomy, dextrose prolotherapy, silicone, saline lavage, saline injection without lavage, analgesic agents, non-steroidal anti-inflammatory drugs, glucosamine, somatostatin, sodium pentosan polysulfate, chloroquine, mucopolysaccharide polysulfuric acid ester, lactic acid solution, and thiotepa cytostatica have been investigated as potentially therapeutic in the treatment of arthritic joints. Despite the lack of strong, convincing, and reproducible evidence that any of the intra-articular therapies significantly alters the progression of osteoarthritis, corticosteroids and hyaluronic acid are widely used in patients who have failed other therapeutic modalities for lack of efficacy or toxicity. As a practical approach for a knee with effusion, steroid injections should be considered while the presence of symptomatic "dry" knees may favour the hyaluronic acid approach. The virtual absence of serious side effects, coupled with the perceived benefits, make these approaches attractive. PMID:12954956

  4. Autonomous Soaring Flight Results

    NASA Technical Reports Server (NTRS)

    Allen, Michael J.

    2006-01-01

    A viewgraph presentation on autonomous soaring flight results for Unmanned Aerial Vehicles (UAV)'s is shown. The topics include: 1) Background; 2) Thermal Soaring Flight Results; 3) Autonomous Dolphin Soaring; and 4) Future Plans.

  5. Vehicle Technologies Program Results

    SciTech Connect

    2009-06-19

    The Vehicle Technologies Program's progress is closely monitored by both internal and external organizations. The Program's results are detailed in a wide range of documents and tools that can be accessed through the PIR website. Descriptions of these materials are provided on this program results page.

  6. Getting Districtwide Results

    ERIC Educational Resources Information Center

    McBeath, Angus

    2006-01-01

    This monograph is based on a keynote presentation by Angus McBeath at the "Getting Districtwide Results" Conference in Long Beach, California, which was co-sponsored by the Cross City Campaign for Urban School Reform and Focus on Results. The author, a former superintendent of the Edmonton Public Schools, how his school district was "forced" and…

  7. Recent results from TRISTAN

    SciTech Connect

    Enomoto, Ryoji

    1997-01-01

    TRISTAN results on {gamma}{gamma} physics from 1994 to 1995 are reviewed in this report. We have systematically investigated jet production, the {gamma}-structure function, and charm pair production in {gamma}{gamma} processes. The results are discussed, and future prospects are presented.

  8. Recent results from CDF

    SciTech Connect

    R. Harr

    2004-01-26

    The authors report on the recent heavy-quark results from CDF in Run IIa. They focus on a selection of mature analyses that demonstrate the capabilities of the experiment to extract interesting physics from the data. A few of the results presented have already been submitted for publication and papers are being prepared for most of the others.

  9. Diffraction Results from CDF

    SciTech Connect

    Goulianos, Konstantin

    2012-04-01

    We present final results by the CDF II collaboration on diffractive W and Z production, report on the status of ongoing analyses on diffractive dijet production and on rapidity gaps between jets, and briefly summarize results obtained on exclusive production pointing to their relevance to calibrating theoretical models used to predict exclusive Higgs-boson production at the LHC.

  10. Unfavourable results in hypospadias

    PubMed Central

    Agrawal, Karoon; Misra, Anshumali

    2013-01-01

    Hypospadias urethroplasty is considered difficult as the complications and unfavourable results are not uncommon. At the turn of the century, due to a better understanding of applied anatomy of hypospadias, new techniques were developed which significantly brought down the complication rate. However unfavourable results are still disturbing. An algorithm for selection of surgery has been presented. Forty three secondary surgeries were performed over 3 years for correction of unfavourable results. The urethrocutaneous fistula was the most common (21%) followed by meatal stenosis (14%) and narrow neourethra (14%). Common unfavourable results have been discussed. On the basis of experience with a large number of hypospadias urethroplasty ‘tips to avoid or minimise unfavourable results’ have been presented. However, one should assess the final outcome of urethroplasty using hypospadias objective scoring evaluation. PMID:24501477

  11. Electroweak results from CDF

    SciTech Connect

    D. S. Waters

    2004-06-02

    Inclusive W and Z production cross-sections have been measured by CDF and certain electroweak parameters extracted with high precision from these measurements. New results on diboson production at the Tevatron are also presented.

  12. Your Kidney Test Results

    MedlinePlus

    ... Important Tests Blood Pressure Serum Albumin Bicarbonate Blood Urea Nitrogen (BUN) Potassium Calcium Phosphorus Results Goal: Your ... level in your blood. BUN checks how much urea, a waste product, is in your blood. Potassium ...

  13. Tevatron direct photon results.

    SciTech Connect

    Kuhlmann, S.

    1999-09-21

    Tevatron direct photon results since DIS98 are reviewed. Two new CDF measurements are discussed, the Run Ib inclusive photon cross section and the photon + Muon cross section. Comparisons with the latest NLO QCD calculations are presented.

  14. Results from MAC

    SciTech Connect

    Chadwick, G.B.

    1983-05-01

    The MAC detector has been exposed at PEP to 40 pb/sup -1/ luminosity of e/sup +/e/sup -/ collisions. The detector is described and recent results of a continuing analysis of hadronic cross section, lepton pair charge asymmetry, Bhabha process, two photon final state and radiative ..mu.. pairs are given. New results on flavor tagging of hadronic events with an inclusive ..mu.., and some searches for new particles are presented.

  15. 2010 Election Results

    NASA Astrophysics Data System (ADS)

    Bamzai, Anjuli; Robinson, Robert; Shirey, Steven

    2010-02-01

    On 3 February 2010, AGU members completed voting for Union and section officers and for directors for the newly approved Board of Directors. Access to voting was provided over the Internet for a period of 31 days. Paper ballots were available upon request. Voting results and analysis were prepared by AGU staff, with results certified by AGU's Tellers Committee on 4 February 2010. Voting was widespread throughout the global base of AGU members. The overall participation rate was 19.2%.

  16. Higgs Results from CMS

    NASA Astrophysics Data System (ADS)

    Bornheim, Adolf

    2014-03-01

    The Nobel Prize in physics 2013 has been awarded to François Englert and Peter W. Higgs for the theoretical discovery of a mechanism that contributes to our understanding of the origin of mass of subatomic particles which plays a crucial role in our understanding of electro-weak symmetry breaking. I will review the experimental results manifesting the discovery of the so called Higgs boson from the perspective of the Compact Muon Solenoid (CMS) collaboration. The review is based on the final results from the proton-proton collision data at 7 TeV and 8 TeV center-of-mass energy, collected in 2011 and 2012 in the initial run of the Large Hadron Collider (LHC) at the European Organization for Nuclear Research (CERN). Results on the properties of the new particle with a mass around 125 GeV, all in agreement with the expectations for the Standard Model (SM) Higgs boson, are highlighted. Latest results on the couplings between the Higgs and fermionic fields, in particular the final results of searches for a Higgs boson decaying into a b-quark or a tau-lepton pair, are presented. Non-SM Higgs searches are briefly summarized. Future perspectives for Higgs physics with CMS at LHC for the next data taking period starting in 2015 and beyond are discussed. CMS Collaboration.

  17. QCD results from CDF

    SciTech Connect

    Plunkett, R.; The CDF Collaboration

    1991-10-01

    Results are presented for hadronic jet and direct photon production at {radical}{bar s} = 1800 GeV. The data are compared with next-to-leading QCD calculations. A new limit on the scale of possible composite structure of the quarks is also reported. 12 refs., 4 figs.

  18. New Results from Hermes

    NASA Astrophysics Data System (ADS)

    Tytgat, M.

    2004-06-01

    An overview is given of selected recent HERMES results obtained from measurements performed during the first running period of HERA. These topics include inclusive g1(x)-measurements with a NLO QCD analysis, polarized quark distribution extraction, b1(x)-measurement, double spin asymmetries in vector meson production, ρ0-nuclear transparency and finally quark fragmentation in nuclei.

  19. Reporting Research Results Effectively

    ERIC Educational Resources Information Center

    Volkwein, J. Fredericks

    2010-01-01

    Assessment research is at its best when it packages research results and data so that they can be digested by multiple audiences. Too many assessment researchers spend all their efforts planning and executing the research project with little attention to closing the loop at the end. If assessment findings are not communicated effectively, the…

  20. 2006 Election Results

    NASA Astrophysics Data System (ADS)

    Staudt, Amanda C.; Given, Holly K.; McDonough, William F.

    2006-02-01

    The voting by the membership for Union and Section officers for the 2006-2008 term was completed on 10 January. Voting was conducted electronically through the Internet using commercial surveying software. Paper ballots were available upon request. The tallying and recording of the elections was managed by AGU staff using the Web-Surveyor software. The results of the voting are listed below.

  1. [The applicability of results].

    PubMed

    Marín-León, I

    2015-11-01

    The ultimate aim of the critical reading of medical literature is to use the scientific advances in clinical practice or for innovation. This requires an evaluation of the applicability of the results of the studies that have been published, which begins with a clear understanding of these results. When the studies do not provide sufficient guarantees of rigor in design and analysis, the conditions necessary for the applicability of the results are not met; however, the fact that the results are reliable is not enough to make it worth trying to use their conclusions. This article explains how carrying out studies in experimental or artificial conditions often moves them away from the real conditions in which they claim to apply their conclusions. To evaluate this applicability, the article proposes evaluating a set of items that will enable the reader to determine the likelihood that the benefits and risks reported in the studies will yield the least uncertainty in the clinical arena where they aim to be applied. PMID:26454562

  2. Recent results from MAC

    SciTech Connect

    MAC Collaboration

    1982-05-01

    Some preliminary results from the MAC detector at PEP are presented. These include measurements of the angular distribution of ..gamma gamma.., ..mu mu.. and tau tau final states, a determination of the tau lifetime, a measurement of R, and a presentation of the inclusive muon p/sub perpendicular/ distribution for hadronic events.

  3. Implementation Challenges and Results

    ERIC Educational Resources Information Center

    Walters, Kirk; Sorensen, Nicholas

    2013-01-01

    This paper describes the implementation of the online and f2f summer algebra courses that were delivered in summers 2011 and 2012. These data will be used to frame the impact results presented in an earlier paper. In particular, the paper will provide a detailed picture of how the online course was structured and the types of supports provided to…

  4. NIH Research to Results

    MedlinePlus

    ... Past Issues Special Section: Focus on Communication NIH Research to Results Past Issues / Fall 2008 Table of Contents For an enhanced version of this page please turn Javascript on. NIDCD-funded researchers from ... An NIDCD-funded research team says it might be possible in the ...

  5. NIH Research to Results

    MedlinePlus

    ... Current Issue Past Issues Sexually Transmitted Diseases NIH Research to Results Past Issues / Fall 2008 Table of Contents For an enhanced version of this page please turn Javascript on. Testing very young babies ... according to recent research funded by the National Institute of Allergy and ...

  6. Sharing Research Results

    ERIC Educational Resources Information Center

    Ashbrook, Peggy

    2011-01-01

    There are many ways to share a collection of data and students' thinking about that data. Explaining the results of science inquiry is important--working scientists and amateurs both contribute information to the body of scientific knowledge. Students can collect data about an activity that is already happening in a classroom (e.g., the qualities…

  7. Recent CDF results

    SciTech Connect

    Gomez, Gervasio; /Cantabria Inst. of Phys.

    2007-11-01

    As of November of 2007, the CDF detector has recorded approximately 2.7 fb{sup -1} of data. This contribution describes some of the most recent and most relevant results from the CDF collaboration in all areas of its wide physics program, as well as some insights into the Tevatron reach for Higgs searches within the next few years.

  8. Steam-explosion pretreatment of wood: Effect of chip size, acid, moisture content and pressure drop.

    PubMed

    Brownell, H H; Yu, E K; Saddler, J N

    1986-06-01

    Material balances for pentosan, lignin, and hexosan, during steam-explosion pretreatment of aspenwood, showed almost quantitative recovery of cellulose in the water-insoluble fraction. Dilute acid impregnation resulted in more selective hydrolysis of pentosan relative to undesirable pyrolysis, and gave a more accessible substrate for enzymatic hydrolysis. Thermocouple probes, located inside simulated aspenwood chips heated in 240 degrees C-saturated steam, showed rapid heating of air-dry wood, whereas green or impregnated wood heated slowly. Small chips, 3.2 mm in the fiber direction, whether green or airdry gave approximately equal rates of pentosan destruction and solubilization, and similar yields of glucose and of total reducing sugars on enzymatic hydrolysis with Trichoderma harzianum. Partial pyrolysis, destroying one third of the pentosan of aspenwood at atmospheric pressure by dry steam at 276 degrees C, gave little increase in yield of reducing sugars on enzymatic hydrolysis. Treatment with saturated steam at 240 degrees C gave essentially the same yields of glucose and of total reducing sugars, and the same yields of butanediol and ethanol on fermentation with Klebsiella pneumoniae, whether or not 80% of the steam was bled off before explosion and even if the chips remained intact, showing that explosion was unnecessary. PMID:18555395

  9. Steam-explosion pretreatment of wood: effect of chip size, acid, moisture content and pressure drop

    SciTech Connect

    Brownell, H.H.; Yu, E.K.C.; Saddler, J.N.

    1986-06-01

    Material balances for pentosan, lignin, and hexosan, during steam-explosion pretreatment of aspenwood, showed almost quantitative recovery of cellulose in the water-insoluble fraction. Dilute acid impregnation resulted in more selective hydrolysis of pentosan relative to undesirable pyrolysis, and gave a more accessible substrate for enzymatic hydrolysis. Thermocouple probes, located inside simulated aspenwood chips heated in 240 degrees C-saturated steam, showed rapid heating of air-dry wood, whereas green or impregnated wood heated slowly. Small chips, 3.2 mm in the fiber direction, whether green or air dry gave approximately equal rates of pentosan destruction and solubilization, and similar yields of glucose and of total reducing sugars on enzmatic hydrolysis with Trichoderma harzianum. Partial pyrolysis, destroying one-third of the pentosan of aspenwood at atmospheric pressure by dry steam at 276 degrees C, gave little increase in yield of reducing sugars on enzymatic hydrolysis. Treatment with saturated steam at 240 degrees C gave essentially the same yields of butanediol and ethanol on fermentation with Klebsiella pneumoniae, whether or not 80% of the steam was bled off before explosion and even if the chips remained intact, showing that explosion was unnecessary. 17 references.

  10. New results from RENO

    NASA Astrophysics Data System (ADS)

    Seo, Seon-Hee; RENO Collaboration

    2014-09-01

    Neutrino oscillation is well known but one of the oscillation parameters, θ13, has not been well measured until 2012. The main goal of RENO (Reactor Experiment for Neutrino Oscillation) is to measure the θ13 using reactor neutrinos. RENO is located in Yonggwang, South Korea, where there are six reactor cores with a total of 16.5 GWth. By detecting the electron anti-neutrinos from nuclear fission processes from the reactors, RENO measured (4.9 sigma) the θ13 in 2012 with 220 live days of data. Since then we have been updating our results more precisely with increased statistics and improved systematics. In this talk, we would like to present our new results (800 live days of data) obtained by a shape analysis method. Excess of neutrino-like events at 5 MeV seen in our data is also discussed.

  11. Dosimetric results on EURECA

    NASA Technical Reports Server (NTRS)

    Reitz, G.

    1995-01-01

    Detector packages were exposed on the European Retrievable Carrier (EURECA) as part of the Biostack experiment inside the Exobiology and Radiation Assembly (ERA) and at several locations around EURECA. The packages consist of different plastic nuclear track detectors, nuclear emulsions and thermoluminescence dosimeters (TLD's). Evaluation of these detectors yields data on absorbed dose and particle and LET spectra. Preliminary results of absorbed dose measurements in the EURECA dosimeter packages are reported and compared to results of the LDEF experiments. The highest dose rate measured on EURECA is 63.3 plus or minus 0.4 mGy d(exp -1) behind a shielding thickness of 0.09 g cm(exp -2) in front of the detector package.

  12. Results from SAGE II

    SciTech Connect

    Nico, J.S.

    1994-10-01

    The Russian-American Gallium solar neutrino Experiment (SAGE) began the second phase of operation (SAGE II) in September of 1992. Monthly measurements of the integral flux of solar neutrinos have been made with 55 tonnes of gallium. The K-peak results of the first nine runs of SAGE II give a capture rate of 66{sub -13}{sup +18} (stat) {sub -7}{sup +5} (sys) SNU. Combined with the SAGE I result of 73{sub -16}{sup +18} (stat) {sub -7}{sup 5} (sys) SNU, the capture rate is 69{sub -11}{sup +11} (stat) {sub -7}{sup +5} (sys) SNU. This represents only 52%--56% of the capture rate predicted by different Standard Solar Models.

  13. Dosimetric results on EURECA

    SciTech Connect

    Reitz, G.

    1995-02-01

    Detector packages were exposed on the European Retrievable Carrier (EURECA) as part of the Biostack experiment inside the Exobiology and Radiation Assembly (ERA) and at several locations around EURECA. The packages consist of different plastic nuclear track detectors, nuclear emulsions and thermoluminescence dosimeters (TLD`s). Evaluation of these detectors yields data on absorbed dose and particle and LET spectra. Preliminary results of absorbed dose measurements in the EURECA dosimeter packages are reported and compared to results of the LDEF experiments. The highest dose rate measured on EURECA is 63.3 plus or minus 0.4 mGy d(exp -1) behind a shielding thickness of 0.09 g cm(exp -2) in front of the detector package.

  14. Space Shuttle radargrammetry results

    NASA Technical Reports Server (NTRS)

    Leberl, F.; Domik, G.; Raggam, J.; Cimino, J.; Kobrick, M.

    1986-01-01

    Preliminary results on the radargrammetric processing of SIR-A and SIR-B data are presented. Radargrammetric processing was applied to images of the Trinity National Forest in Northern California, the islands of Cephalonia, Ithaka, and Sardegna, Mt. Shasta, and Cordon La Grasa, Argentina. The preliminary processing of the SIR-A and SIR-B data has produced digital elevation models, stereo models, and a contour map.

  15. PDX experimental results

    SciTech Connect

    Meade, D.; Arunasalam, V.; Barnes, C.

    1981-01-01

    The main objectives of the Poloidal Divertor Experiment (PDX) are to: (1) determine the effectiveness of poloidal divertors in controlling impurities in high temperature plasmas, (2) use the poloidal divertor to provide clean plasmas for confinement and high beta studies, and (3) investigate the effect of cross-section shaping on plasma confinement and MHD properties. In this paper, we report the results obtained during initial divertor operation of the PDX.

  16. Recent results from MAMI

    SciTech Connect

    Arends, Hans-Juergen

    2011-10-24

    The Mainz Microtron MAMI is an ideal facility to study the hadron structure with the electromagnetic probe. With the new accelerator stage (HDSM), which went into operation in 2007, high-intensity polarized electron and photon beams with energies up to 1.6 GeV are delivered to the experiments. Polarized targets and recoil polarimeters in combination with dedicated detectors are available for precision experiments in hadron physics. In this article, an overview over selected recent results is given.

  17. Results from SAGE

    SciTech Connect

    Abdurashitov, J.N.; Gavrin, V.N.; Girin, S.V.

    1996-04-01

    The Russian-American Gallium Solar Neutrino Experiment (SAGE) is described. Beginning in September 1992, SAGE II data were taken with 55 tons of Ga and with significantly reduced backgrounds. The solar neutrino flux measured by 31 extractions through October 1993 is presented. The result of 69 {+-} 10 +5/{minus}7 SNU is to be compared with a Standard Solar Model prediction of 132 SNU.

  18. GIRAFFE test results summary

    SciTech Connect

    Yokobori, S.; Arai, K.; Oikawa, H.

    1996-03-01

    A passive system can provide engineered safety features enhancing safety system reliability and plant simplicity. Toshiba has conducted the test Program to demonstrate the feasibility of the SBWR passive safety system using a full-height, integral system test facility GIRAFFE. The test facility GIRAFFE models the SBWR in full height to correctly present the gravity driving head forces with a 1/400 volume scale. The GIRAFFE test Program includes the certification tests of the passive containment cooling system (PCCS) to remove the post-accident decay heat and the gravity driven cooling system (GDCS) to replenish the reactor coolant inventory during a LOCA. The test results have confirmed the PCCS and GDCS design and in addition, have demonstrated the operation of the pCCS with the presence of a lighter-than-steam noncondensable as well as with the presence of a heavier-than-steam, noncondensable. The GIRAFFE test Program has also provided the database to qualify a best estimate thermal-hydraulic computer code TRAC. The post test analysis results have shown that TRAC can accurately predict the PCCS heat removal Performance and the containment pressure response to a LOCA. This paper summarizes the GIRAFFE test results to investigate post-LOCA PCCS heat removal performance and post-test analysis using TRAC.

  19. MOPEX Workshop Results Revisited

    NASA Astrophysics Data System (ADS)

    Leavesley, G. H.

    2003-12-01

    A complementary program to the Prediction in Ungauged Basins (PUB) program is the Model Parameter Estimation Experiment (MOPEX). The primary goal of MOPEX is to develop techniques for the a priori estimation of parameters in land surface parameterization schemes in atmospheric models and in hydrologic models. A recent MOPEX workshop evaluated the use of a priori estimated parameters in eight hydrologic models. A data set of mean areal precipitation, temperature, and potential evapotranspiration was provided for each of 12 basins located predominantly in the southeastern United States. While workshop results provided valuable insight to some problems in a priori parameter estimation within and among models, additional questions remain. Using additional data sets for the 12 basins, alternative parameter estimation techniques are being evaluated to compare the use of distributed values of precipitation and temperature to the use of mean areal values in the original study. Also, the magnitudes of the uncertainty in streamflow prediction resulting from errors in the meteorological variables and their distribution are being compared with the magnitudes of uncertainty associated with errors in parameter estimates of basin physical characteristics. The U.S Geological Survey's distributed-parameter watershed model PRMS was one of the eight models used in the MOPEX workshop and is the model being used to conduct these further studies. Results of this investigation are presented.

  20. The Viking biology results

    NASA Technical Reports Server (NTRS)

    Klein, Harold P.

    1989-01-01

    A brief review of the purposes and the results from the Viking Biology experiments is presented, in the expectation that the lessons learned from this mission will be useful in planning future approaches to the biological exploration of Mars. Since so little was then known about potential micro-environments on Mars, three different experiments were included in the Viking mission, each one based on different assumptions about what Martian organisms might be like. In addition to the Viking Biology Instrument (VBI), important corollary information was obtained from the Viking lander imaging system and from the molecular analysis experiments that were conducted using the gas chromatograph-mass spectrometer (GCMS) instrument. No biological objects were noted by the lander imaging instrument. The GCMS did not detect any organic compounds. A description of the tests conducted by the Gas Exchange Experiment, the Labeled Release experiment, and the Pyrolytic Release experiment is given. Results are discussed. Taken as a whole, the Viking data yielded no unequivocal evidence for a Martian biota at either landing site. The results also revealed the presence of one or more reactive oxidants in the surface material and these need to be further characterized, as does the range of micro-environments, before embarking upon future searches for extant life on Mars.

  1. Certification of computational results

    NASA Technical Reports Server (NTRS)

    Sullivan, Gregory F.; Wilson, Dwight S.; Masson, Gerald M.

    1993-01-01

    A conceptually novel and powerful technique to achieve fault detection and fault tolerance in hardware and software systems is described. When used for software fault detection, this new technique uses time and software redundancy and can be outlined as follows. In the initial phase, a program is run to solve a problem and store the result. In addition, this program leaves behind a trail of data called a certification trail. In the second phase, another program is run which solves the original problem again. This program, however, has access to the certification trail left by the first program. Because of the availability of the certification trail, the second phase can be performed by a less complex program and can execute more quickly. In the final phase, the two results are compared and if they agree the results are accepted as correct; otherwise an error is indicated. An essential aspect of this approach is that the second program must always generate either an error indication or a correct output even when the certification trail it receives from the first program is incorrect. The certification trail approach to fault tolerance is formalized and realizations of it are illustrated by considering algorithms for the following problems: convex hull, sorting, and shortest path. Cases in which the second phase can be run concurrently with the first and act as a monitor are discussed. The certification trail approach are compared to other approaches to fault tolerance.

  2. Pressure locking test results

    SciTech Connect

    DeWall, K.G.; Watkins, J.C.; McKellar, M.G.; Bramwell, D.

    1996-12-01

    The U.S. Nuclear Regulatory Commission (NRC), Office of Nuclear Regulatory Research, is funding the Idaho National Engineering Laboratory (INEL) in performing research to provide technical input for their use in evaluating responses to Generic Letter 95-07, {open_quotes}Pressure Locking and Thermal Binding of Safety-Related Power-Operated Gate Valves.{close_quotes} Pressure locking and thermal binding are phenomena that make a closed gate valve difficult to open. This paper discusses only the pressure locking phenomenon in a flexible-wedge gate valve; the authors will publish the results of their thermal binding research at a later date. Pressure locking can occur when operating sequences or temperature changes cause the pressure of the fluid in the bonnet (and, in most valves, between the discs) to be higher than the pressure on the upstream and downstream sides of the disc assembly. This high fluid pressure presses the discs against both seats, making the disc assembly harder to unseat than anticipated by the typical design calculations, which generally consider friction at only one of the two disc/seat interfaces. The high pressure of the bonnet fluid also changes the pressure distribution around the disc in a way that can further contribute to the unseating load. If the combined loads associated with pressure locking are very high, the actuator might not have the capacity to open the valve. The results of the NRC/INEL research discussed in this paper show that the relationship between bonnet pressure and pressure locking stem loads appears linear. The results also show that for this valve, seat leakage affects the bonnet pressurization rate when the valve is subjected to thermally induced pressure locking conditions.

  3. Results of railgun experiments

    SciTech Connect

    Hawke, R.S.; Brooks, A.L.; Fowler, C.M.; Peterson, D.R.

    1983-04-01

    During the 1979 Megagauss II conference the hypervelocity potential of railguns and the pulsed power technology needed to power them were discussed. Since then, many laboratories have initiated railgun R and D projects for a variety of potential applications. Los Alamos and Lawrence Livermore National Laboratories initiated a collaborative experimental railgun project which resulted in several successes in accelerating projectiles to high velocities, emphasized the limits on railgun operation, and indicated that the numerical modeling of railgun operation was in good agreement with the experiments.

  4. SPEAR results, 1981

    SciTech Connect

    Scharre, D.L.

    1981-09-01

    New results from SPEAR on the inclusive photon spectrum at the psi' and on J/psi radiative transitions are presented. Evidence for an eta/sub c/' candidate is observed in the psi' inclusive photon spectrum at a mass M = 3592 +- 5 MeV. A new resonance, the theta(1640) which is observed to decay into eta eta, has been seen in radiative transitions from the J/psi. The spin-parity of the l(1440), previously observed in J/psi radiative transitions and originally identified as the E(1420), has been determined to be 0/sup -/.

  5. Lithium cell test results

    NASA Technical Reports Server (NTRS)

    Bragg, B. J.

    1977-01-01

    Three lithium SO2 cells, two lithium CF cells, and a vinyl chloride cell, all with crimped seals, and all strictly experimental, were independently discharged on resistors. Three temperatures were used and several different storage temperatures. Discharge rate generally on the nominal discharges were 0.1 amp, 0.5 amp, and 1 amp. Tests results show that the crimp seals are inadequate, especially for the SO2 cells. Normal discharges present no hazards. All cells discharge to zero. The problem of lithium cell explosions, such as occurred during off-limits testing, is discussed.

  6. Recent result from RENO

    NASA Astrophysics Data System (ADS)

    Seo, Hyunkwan; RENO Collaboration

    2016-05-01

    The Reactor Experiment for Neutrino Oscillation (RENO) started data-taking from August, 2011 and has measured the smallest neutrino mixing angle θ13 by observing the disappearance of reactor antineutrinos. Antineutrinos from the six reactors at Hanbit Nuclear Power Plant in Korea are detected and compared by the two identical detectors located in the near and far distances from the reactor array center. We present new results on precisely measured sin 22θ13 value and |Δm2 ee| based on spectral analysis using the 800 days of data sample, which are taken from August, 2011 to Dec., 2013.

  7. Results from AMANDA

    NASA Astrophysics Data System (ADS)

    Wiebusch, Christopher; Ahrens, J.; Bai, X.; Barwick, S. W.; Becka, T.; Becker, K.-H.; Bertrand, D.; Bernadini, E.; Binon, F.; Biron, A.; Böser, S.; Botner, O.; Bouchta, A.; Bouhali, O.; Burgess, T.; Carius, S.; Castermans, T.; Chen, A.; Chirkin, D.; Conrad, J.; Cooley, J.; Cowen, D. F.; Davour, A.; de Clercq, C.; De Young, T.; Desiati, P.; Dewulf, J.-P.; Doksus, P.; Ekström, P.; Feser, T.; Gaisser, T. K.; Gaug, M.; Gerhardt, L.; Goldschmidt, A.; Hallgren, A.; Halzen, F.; Hanson, K.; Hardtke, R.; Hauschildt, T.; Hellwig, M.; Herquet, P.; Hill, G. C.; Hulth, P. O.; Hundertmark, S.; Jacobsen, J.; Karle, A.; Koci, B.; Köpke, L.; Kowalski, M.; Kuehn, K.; Lamoureux, J. I.; Leich, H.; Leuthold, M.; Lindahl, P.; Liubarsky, I.; Madsen, J.; Marciniewski, P.; Matis, H. S.; McParland, C. P.; Minaeva, Y.; Miočinović, P.; Mock, P. C.; Morse, R.; Nahnhauer, R.; Neunhöffer, T.; Niessen, P.; Nygren, D. R.; Ogelman, H.; Olbrechts, Ph.; Pérez de Los Heros, C.; Pohl, A. C.; Price, P. B.; Przybylski, G. T.; Rawlins, K.; Resconi, E.; Rhode, W.; Ribordy, M.; Richter, S.; Rodríguez Martino, J.; Ross, D.; Sander, H.-G.; Schmidt, T.; Schneider, D.; Schwarz, R.; Silvestri, A.; Solarz, M.; Spiczak, G. M.; Spiering, C.; Steele, D.; Steffen, P.; Stokstad, R. G.; Sudhoff, P.; Sulanke, K.-H.; Taboada, I.; Thollander, L.; Tilav, S.; Walck, C.; Weinheimer, C.; Wiebusch, C. H.; Wiedemann, C.; Wischnewski, R.; Wissing, H.; Woschnagg, K.; Yodh, G.; Young, S.

    The Antarctic Muon and Neutrino Detector Array (AMANDA) is a high-energy neutrino telescope operating at the geographic South Pole. It is a lattice of photo-multiplier tubes buried deep in the polar ice. The primary goal of this detector is to discover astrophysical sources of high energy neutrinos. We describe the detector methods of operation and present results from the AMANDA-B10 prototype. We demonstrate the improved sensitivity of the current AMANDA-II detector. We conclude with an outlook to the envisioned sensitivity of the future IceCube detector.

  8. Recent BABAR Results

    SciTech Connect

    Eigen, Gerald

    2015-04-29

    We present herein the most recent BABAR results on direct CP asymmetry measurements in B → Xsγ, on partial branching fraction and CP asymmetry measurements in B → Xs+-, on a search for B → π/ηℓ+- decays, on a search for lepton number violation in B+ → X-+ℓ'+ modes and a study of B0 →ωω and B0 → ωφ decays.

  9. Archeomagnetic Results From Spain

    NASA Astrophysics Data System (ADS)

    Chauvin, A.; Gomez-Paccard, M.; Lanos, P.; Osete, M.; McIntosh, G.; Thiriot, J.

    2007-05-01

    A first secular variation (SV) curve for the Iberian Peninsula was computed by hierarchical Bayesian method using a total of 134 archaeomagnetic directions with ages ranging from 775 BC to 1959 A.D. A general agreement is observed between the Iberian curve and the French and German SV curves, excepted between the 11th and 14th centuries. The analysis of these three reference curves indicates that SV in western Europe is characterized by three major directional changes at 125, 200, and 1350 A.D. It is suggested that these cusps are regional features of the geomagnetic field. Archeointensity studies were also conducted on 24 Spanish archeomagnetic sites (220 AD to 1959 AD). Intensity data were obtained using the original Thellier method with anisotropy and cooling rates corrections. Our new 24 data, together with 62 previously published results, were used to recover, by Bayesian modelling, the geomagnetic field intensity evolution over the past two millennia for western Europe. Our results indicate that the geomagnetic intensity remains more or less constant between the 1st and 4th centuries, and between the 13th and 15th centuries, whereas an important decrease occurs during the last 5 centuries. The evolution of the Earth's magnetic field intensity during High Middle Ages remains uncertain. The available geomagnetic global models predict reasonably well our data.

  10. Unfavourable results in pollicisation

    PubMed Central

    Thatte, Mukund R.; Nehete, Sushil; Garude, Kirti; Mehta, Rujuta

    2013-01-01

    Pollicisation of the index finger is perhaps one of the most complex and most rewarding operations in hand and plastic surgery. It however has a steep learning curve and demands very high skill levels and experience. There are multiple pitfalls and each can result in an unfavourable result. In essence we need to: Shorten the Index, recreate the carpo metacarpal joint from the metacarpo phalangeal (MP) joint, rotate the digit by about 120° for pulp to pulp pinch, palmarly abduct by 40-50° to get a new first web gap, Shorten and readjust the tension of the extensors, re attach the intrinsics to form a thenar eminence capable of positioning the new thumb in various functional positions and finally close the flaps forming a new skin envelope. The author has performed over 75 pollicisations personally and has personal experience of some of the issues raised there. The steps mentioned therefore are an algorithm for helping the uninitiated into these choppy waters. PMID:24501467

  11. Spacelab Science Results Study

    NASA Technical Reports Server (NTRS)

    Naumann, R. J.; Lundquist, C. A.; Tandberg-Hanssen, E.; Horwitz, J. L.; Germany, G. A.; Cruise, J. F.; Lewis, M. L.; Murphy, K. L.

    2009-01-01

    Beginning with OSTA-1 in November 1981 and ending with Neurolab in March 1998, a total of 36 Shuttle missions carried various Spacelab components such as the Spacelab module, pallet, instrument pointing system, or mission peculiar experiment support structure. The experiments carried out during these flights included astrophysics, solar physics, plasma physics, atmospheric science, Earth observations, and a wide range of microgravity experiments in life sciences, biotechnology, materials science, and fluid physics which includes combustion and critical point phenomena. In all, some 764 experiments were conducted by investigators from the U.S., Europe, and Japan. The purpose of this Spacelab Science Results Study is to document the contributions made in each of the major research areas by giving a brief synopsis of the more significant experiments and an extensive list of the publications that were produced. We have also endeavored to show how these results impacted the existing body of knowledge, where they have spawned new fields, and if appropriate, where the knowledge they produced has been applied.

  12. Latest Double Chooz results

    NASA Astrophysics Data System (ADS)

    Lasserre, Thierry; Double Chooz Collaboration

    2016-05-01

    I report the latest results from the Double Chooz experiment on the θ13 neutrino mixing angle. Two detectors are located at distances of 400 m and 1050 m from the reactor cores of the Chooz nuclear power station (France) to measure the disappearance of electron antineutrinos. The far detector has been taking data since 2011, accumulating a live time of 467.90 days (66.5 GW-ton-year). In this article we focus on the latest measurement using neutrino-induced neutron capture on hydrogen. A new analysis improved the signal efficiency and reduced the backgrounds and systematic uncertainties, leading to sin2 2θ 13 = 0.095+0.039 -0.038. When combined with the Gadolinium-based analysis this leads to sin2 2θ13 = 0.088+0.33 -0.033. The distortion from the prediction above a visible energy of 4 MeV is confirmed. The near detector started data taking in 2014 and first results shall be reported in 2016.

  13. AMT experiment results

    NASA Technical Reports Server (NTRS)

    Abbe, Brian S.; Pinck, Deborah S.

    1995-01-01

    The Advanced Communications Technology Satellite (ACTS) Mobile Terminal (AMT) experiments have provided a terminal technology testbed for the evaluation of K- and Ka-band mobile satellite communications (satcom). Such a system could prove to be highly beneficial for many different commercial and government mobile satcom users. Combining ACTS' highly concentrated spotbeams with the smaller, higher-gain Ka-band antenna technology, results in a system design that can support a much higher throughput capacity than today's commercial configurations. To date, experiments in such diverse areas as emergency medical applications, enhanced Personal Communication Services (PCS), disaster recovery assistance, military applications, and general voice and data services have already been evaluated. Other applications that will be evaluated over the next year include telemedicine, ISDN, and television network return feed. Baseline AMT performance results will be presented, including Bit Error Rate (BER) curves and mobile propagation data characterizing the K- and Ka-band mobile satcom channel. In addition, observations from many of the application-specific experiments will also be provided.

  14. Organic Separation Test Results

    SciTech Connect

    Russell, Renee L.; Rinehart, Donald E.; Peterson, Reid A.

    2014-09-22

    Separable organics have been defined as “those organic compounds of very limited solubility in the bulk waste and that can form a separate liquid phase or layer” (Smalley and Nguyen 2013), and result from three main solvent extraction processes: U Plant Uranium Recovery Process, B Plant Waste Fractionation Process, and Plutonium Uranium Extraction (PUREX) Process. The primary organic solvents associated with tank solids are TBP, D2EHPA, and NPH. There is concern that, while this organic material is bound to the sludge particles as it is stored in the tanks, waste feed delivery activities, specifically transfer pump and mixer pump operations, could cause the organics to form a separated layer in the tank farms feed tank. Therefore, Washington River Protection Solutions (WRPS) is experimentally evaluating the potential of organic solvents separating from the tank solids (sludge) during waste feed delivery activities, specifically the waste mixing and transfer processes. Given the Hanford Tank Waste Treatment and Immobilization Plant (WTP) waste acceptance criteria per the Waste Feed Acceptance Criteria document (24590-WTP-RPT-MGT-11-014) that there is to be “no visible layer” of separable organics in the waste feed, this would result in the batch being unacceptable to transfer to WTP. This study is of particular importance to WRPS because of these WTP requirements.

  15. GOSAT TANSO operation results

    NASA Astrophysics Data System (ADS)

    Nakajima, Masakatsu; Kuze, Akiihiko; Suto, Hiroshi; Shiomi, Kei

    2010-05-01

    The Greenhouse gases Observing SATellite (GOSAT) observes carbon dioxide (CO2) and methane (CH4) globally from space. It was launched on January 23, 2009 from Tanegashima Space Center. Since February 7, 2009, the Thermal And Near infrared Sensor for carbon Observation Fourier-Transform Spectrometer (TANSO-FTS) and Cloud and Aerosol Imager (TANSO-CAI) have been continuously operated. They acquire global data every three days. For the first six months after the launch, on-orbit function, performance, calibration, and validation have been checked-out. The brief summary of instrument design, pre-launch test results, observation plan (grid and sun glint observation and special target mode), onboard calibration schemes, and the initial on-orbit results of radiometric, geometric and spectroscopic performances are presented. TANSO-FTS Level 1A and 1B data processing algorithm and its updates on the ground are also presented. In addition we will show recent on orbit instrument status such as pointing accuracy, interferogram quality, and radiometric accuracy.

  16. Results from TOTEM

    NASA Astrophysics Data System (ADS)

    Eggert, Karsten

    2013-06-01

    The TOTEM experiment at the CERN LHC is focussed on the measurement of the elastic proton-proton scattering, the total pp cross-section, and all kinds of diffractive phenomena. Detectors housed in "Roman Pots" which can be moved close to the outgoing proton beams allow to trigger on elastic and diffractive protons and to determine their parameters like the momentum loss and the transverse momentum transfer. In addition, charged particle detectors in the forward regions detect almost all inelastic events. Together with the CMS detector, a large solid angle is covered enabling precise studies of Min. Bias as well as Single Diffractive and Double Pomeron Interactions. The results will considerably help the interpretation of the Cosmic Ray Showers at highest energies and will give insight into the proton structure and the QCD theory of strong interactions. TOTEM measured the elastic pp- scattering over a large range of t (the squared momentum transfer) from 10-3 - 4 GeV2. Noneof the considered models could yield a satisfactory fit over the complete range. However, the exponential slope at low |t|-values and the position of the diffractiveminimum are well within the extrapolation from lower energies. The total pp cross-section has been determined in different ways from the extrapolation of the elasticscattering to t=0 (optical point) and the inelastic rate: (i) From the elastic scattering using the optical theorem and the CMS, (ii) luminosity independently, usingthe inelastic rate, elastic scattering and the optical theorem, (iii)ρ independently, by using elastic scattering, inelastic rate and the CMS luminosity. The results for the total crosssection obtained from the different methods are in excellent agreement with each other. First studies of the data on diffractive phenomena havebeen performed by correlating the momentum loss of the forward protons with the topology of the particle flux. The data look very promising and further studies will follow. Since the

  17. Iron Mountain Electromagnetic Results

    SciTech Connect

    Gail Heath

    2012-07-01

    Iron Mountain Mine is located seventeen miles northwest of Redding, CA. After the completion of mining in early 1960s, the mine workings have been exposed to environmental elements which have resulted in degradation in water quality in the surrounding water sheds. In 1985, the EPA plugged ore stoops in many of the accessible mine drifts in an attempt to restrict water flow through the mine workings. During this process little data was gathered on the orientation of the stoops and construction of the plugs. During the last 25 years, plugs have begun to deteriorate and allow acidic waters from the upper workings to flow out of the mine. A team from Idaho National Laboratory (INL) performed geophysical surveys on a single mine drift and 3 concrete plugs. The project goal was to evaluate several geophysical methods to determine competence of the concrete plugs and orientation of the stopes.

  18. Overview of HERMES results

    NASA Astrophysics Data System (ADS)

    Van Hulse, Charlotte

    2016-03-01

    The HERMES experiment has collected a wealth of deep-inelastic scattering data using the 27.6 GeV polarized lepton beam at HERA and various pure gas targets, both unpolarized and polarized. This allowed for a series of diverse and unique measurements. Among them are measurements that provide information on the threedimensional structure of the nucleon, both in momentum space and in position space. Results of measurements of exclusive ω production on an unpolarized and transversely polarized nucleon target, sensitive to the distribution in transverse-position and longitudinalmomentum space, are discussed as well as the three-dimensional extraction of azimuthal asymmetries measured in semi-inclusive deep-inelastic scattering, sensitive to twist-2 and twist-3 distributions in three-dimensional momentum space.

  19. Recent Results from Phobos

    NASA Astrophysics Data System (ADS)

    García, Edmundo; Back, B. B.; Baker, M. D.; Ballintijn, M.; Barton, D. S.; Betts, R. R.; Bickley, A. A.; Bindel, R.; Busza, W.; Carroll, A.; Chai, Z.; Decowski, M. P.; García, E.; Gburek, T.; George, N.; Gulbrandsen, K.; Halliwell, C.; Hamblen, J.; Hauer, M.; Henderson, C.; Hofman, D. J.; Hollis, R. S.; Hołyński, R.; Holzman, B.; Iordanova, A.; Johnson, E.; Kane, J. L.; Khan, N.; Kulinich, P.; Kuo, C. M.; Lin, W. T.; Manly, S.; Mignerey, A. C.; Nouicer, R.; Olszewski, A.; Pak, R.; Reed, C.; Roland, C.; Roland, G.; Sagerer, J.; Seals, H.; Sedykh, I.; Smith, C. E.; Stankiewicz, M. A.; Steinberg, P.; Stephans, G. S. F.; Sukhanov, A.; Tonjes, M. B.; Trzupek, A.; Vale, C.; van Nieuwenhuizen, G. J.; Vaurynovich, S. S.; Verdier, R.; Veres, G. I.; Wenger, E.; Wolfs, F. L. H.; Wosiek, B.; Woźniak, K.; Wysłouch, B.

    2007-02-01

    The PHOBOS detector is one of four heavy ion experiments at the Relativistic Heavy Ion Collider at Brookhaven National Laboratory. In this paper we will review some of the results of PHOBOS from the data collected in p+p, d+Au and Au+Au collisions at nucleon-nucleon center-of-mass energies up to 200 GeV. Evidence is found of the formation of a very high energy density and highly interactive system, which can not be described in terms of hadrons, and has a relatively low baryon density. There is evidence that the system formed is thermalized to a certain degree. Scaling with the number of participants and extended longitudinal scaling behavior are also observed in distributions of produced charged particles.

  20. 2012 election results

    NASA Astrophysics Data System (ADS)

    Robinson, Robert; Tetzlaff, Doerthe

    2012-10-01

    On 4 October 2012, AGU members completed voting for the 2013-2014 leadership term. Union officers, Board members, section and focus group officers, and student and early career representatives to the Council were elected. All members who joined or renewed their membership by 1 July 2012 were eligible to vote in this year's leadership election. The vote was held electronically, and access to voting was provided to all eligible voters for a period of 31 days. The voting was conducted by Survey and Ballot Systems, Inc. (SBS). SBS, which offers election planning and management services, provided unique login credentials and other support services for eligible voters throughout the election. Voting results were certified by SBS on 8 October and by the AGU Tellers Committee on 9 October. The overall participation rate was 21.9%, an increase over previous AGU elections.

  1. Top physics: CDF results

    SciTech Connect

    K. Bloom

    2004-06-23

    The top quark plays an important role in the grand scheme of particle physics, and is also interesting on its own merits. We present recent results from CDF on top-quark physics based on 100-200 pb{sup -1} of p{bar p} collision data. We have measured the t{bar t} cross section in different decay modes using several different techniques, and are beginning our studies of top-quark properties. New analyses for this conference include a measurement of {sigma}{sub t{bar t}} in the lepton-plus-jets channel using a neural net to distinguish signal and background events, and measurements of top-quark branching fractions.

  2. [Vitrification: Principles and results].

    PubMed

    Griveau, J F; Lopes, M; Jouve, G; Veau, S; Ravel, C; Morcel, K

    2015-06-01

    Sperm and embryos cryopreservation is a commonly applied technique for several years. Recently authorized in France, vitrification tends to replace gradually the conventional technique of slow freezing, so upsetting the practices in the management of patients. It allows from now on the cryopreservation of oocytes and opens new perspectives in egg donation either still in fertility preservation. This review thus attempted to examine the contribution of vitrification in the freezing of oocytes and human embryos at various stages of development. If obviously vitrification appears as the current method of choice for the cryopreservation of oocytes as well as blastocysts, the results are less cut as regards embryos to early stages. No increase in adverse obstetric and perinatal outcomes in children conceived from vitrified oocytes or embryos is noted in the literature. PMID:25869444

  3. Recent results from ANTARES

    NASA Astrophysics Data System (ADS)

    Trovato, Agata

    2015-08-01

    Operating 40 km off the coast of France since 2007, the ANTARES detector is the largest deep-sea neutrino telescope in the Northern Hemisphere with an instrumented volume of more than 0.01 cubic kilometers. It consists of an array of 885 photomultipliers detecting the Cherenkov light induced by charged leptons produced by neutrino interactions in and around the detector. The primary goal of ANTARES is to search for astrophysical neutrinos in the TeV-PeV range. This comprises generic searches for any diffuse cosmic neutrino flux as well as more specific searches for astrophysical galactic and extragalactic sources. The search program also includes multi-messenger analyses based on time and/or space coincidences with other cosmic probes. The ANTARES observatory is sensitive to a wide-range of other phenomena, from atmospheric neutrino oscillations to dark matter annihilation. In this contribution, recent results from the ANTARES neutrino telescope will be presented.

  4. Fish community results

    SciTech Connect

    Hickman, G.D.; Scott, E.M. Jr.; Brown, A.M.

    1991-05-01

    The Tennessee Valley Authority (TVA) operates 9 reservoirs on the Tennessee River and 37 reservoirs on its tributaries. TVA is committed to maintaining the health of aquatic resources created when the reservoir system was built. To that end, TVA in cooperation with Valley states, operates a water resource monitoring program that includes physical, chemical, and biological data collection components. Biological monitoring will target the following selected elements within three zones of the reservoir (inflow, transition, and forebay): Sediment/Water-column Acute Toxicity Screening, Benthic macroinvertebrates, and Fish. Reservoir fisheries monitoring is divided into the following activities: Fish Biomass, Fish Tissue Contamination, Fish Community Monitoring, and Fish Health Assessment. This report presents the results of fish community monitoring and fish health assessments.

  5. System results from FRECOPA

    NASA Technical Reports Server (NTRS)

    Durin, Christian; Berthoud, Lucinda; Mandeville, Jean-Claude

    1995-01-01

    The work carried out over the past three years on FRECOPA and the LDEF has enabled a large quantity of information to be collected, part of which has already been exploited. As far as CNES is concerned, the major spin-offs of this mission mainly focus on the orbital environment and the behavior of materials in such an environment. With respect to the environment, the authors shall develop the lessons learned from expert appraisals on impacts by microparticles, which are the main feature observed in this area. As for the materials, the results show a variety of behavior when subjected to the space environment and even now constitute a wealth of information for the designing and validation of future mechanical systems. Apart from these direct spin-offs, there are repercussions on in-flight and ground testing, the calibration of test benches and improvements to simulation models.

  6. FIRE Science Results 1989

    NASA Technical Reports Server (NTRS)

    Mcdougal, David S. (Editor)

    1990-01-01

    FIRE (First ISCCP Regional Experiment) is a U.S. cloud-radiation research program formed in 1984 to increase the basic understanding of cirrus and marine stratocumulus cloud systems, to develop realistic parameterizations for these systems, and to validate and improve ISCCP cloud product retrievals. Presentations of results culminating the first 5 years of FIRE research activities were highlighted. The 1986 Cirrus Intensive Field Observations (IFO), the 1987 Marine Stratocumulus IFO, the Extended Time Observations (ETO), and modeling activities are described. Collaborative efforts involving the comparison of multiple data sets, incorporation of data measurements into modeling activities, validation of ISCCP cloud parameters, and development of parameterization schemes for General Circulation Models (GCMs) are described.

  7. LSND neutrino oscillation results

    SciTech Connect

    Louis, W.C.; LSND Collaboration

    1996-10-01

    The LSND (Liquid Scintillator Neutrino Detector) experiment at Los Alamos has conducted a search for muon antineutrino {r_arrow} electron antineutrino oscillations using muon neutrinos from antimuon decay at rest. The electron antineutrinos are detected via the reaction electron antineutrino + proton {r_arrow} positron + neutron, correlated with the 2.2-MeV gamma from neutron + proton {r_arrow} deuteron + gamma. The use of tight cuts to identify positron events with correlated gamma rays yields 22 events with positron energy between 36 and 60 MeV and only 4.6 {+-} 0.6 background events. The probability that this excess is due entirely to a statistical fluctuation is 4.1 {times} 10{sup -8}. A chi-squared fit to the entire positron sample results in a total excess of 51.8 {sup +18.7}{sub -16.9} {+-} 8.0 events with positron energy between 20 and 60 MeV. If attributed to muon antineutrino {r_arrow} electron antineutrino oscillations, this corresponds to an oscillation probability (averaged over the experimental energy and spatial acceptance) of (0.31 {+-} 0.12 {+-} 0.05){percent}. 10 refs., 7 figs., 1 tab.

  8. ALICE TPC commissioning results

    NASA Astrophysics Data System (ADS)

    Larsen, D. T.; Alice Tpc Collaboration

    2010-05-01

    ALICE is a dedicated heavy-ion experiment at CERN LHC aiming to study the properties of the quark-gluon plasma. A lead-lead collision might produce several 10 00 new particles. Detailed study of the event requires precise measurements of the particle tracks. A 90 m3 Time Projection Chamber (TPC) with more than 500 000 read-out pads was built as the main central barrel tracker. Collisions can be recorded at a rate of up to about 1 kHz. The front-end electronics, designed from FPGAs and custom ASICs, performs shaping, amplification, digitisation and digital filtering of the signals. The data are forwarded to DAQ via 216 1.25 Gb/s fibre-optical links. Configuration, control and monitoring is done by an embedded Linux system on the front-end electronics. Before production runs with beam, extensive commissioning using tracks from cosmics and from the laser system as well as clusters from radioactive krypton gas is needed. Extensive results have been obtained with respect to the performance of the TPC including its sub-systems.

  9. ESR teleradiology survey: results.

    PubMed

    2016-08-01

    With recent developments of teleradiology technology and services, it has become necessary to better evaluate its extent and use among different countries in Europe. With this goal in mind, the ESR launched two specific surveys intended to gather the current state of adoption and implementation of teleradiology in clinical practice. A special focus on differentiating between insourcing teleradiology services among partners of the same organisation and outsourcing to external services was an essential part of the design of these surveys. The first survey was addressed to 44 national societies of different countries in Europe, while the second survey was intended for all practicing radiologist ESR members. While the results of these surveys reported here may provide a wealth of information to better understand the trends in adoption of teleradiology in Europe, they only represent a snapshot at a certain point in time. The rapid development of telecommunication tools as well as a fundamental change in practice and healthcare economics will certainly influence these observations in the upcoming years. These data, however, will provide objective and relevant parameters for supporting the efforts of experts and policy makers in promoting appropriate criteria and guidelines for adequate use of teleradiology in clinical practice. Main Messages • Understand concepts and challenges of teleradiology • Provide insight into current trends and solutions for teleradiology • Compare differences in teleradiolgy strategies between countries in Europe • Establish a reference on statistical data of usage of teleradiology in Europe. PMID:27188379

  10. Results from hadron colliders

    SciTech Connect

    Pondrom, L.G. )

    1990-12-14

    The present status of hadron collider physics is reviewed. The total cross section for {bar p} + p has been measured at 1.8 TeV: {sigma}{sub tot} = 72.1 {plus minus} 3.3 mb. New data confirm the UA2 observation of W/Z {yields} {bar q}q. Precision measurements of M{sub W} by UA2 and CDF give an average value M{sub W} = 80.13 {plus minus} 0.30 GeV/c{sup 2}. When combined with measurements of M{sub Z} from LEP and SLC this number gives sin{sup 2}{theta}{sub W} = 0.227 {plus minus} 0.006, or m{sub top} = 130{sub {minus}60}{sup +40} GeV/c{sup 2} from the EWK radiative correction term {Delta}r. Evidence for hadron colliders as practical sources of b quarks has been strengthened, while searches for t quarks have pushed the mass above M{sub W}: m{sub top} > 89 GeV/c{sup 2} 95% cl (CDF Preliminary). Searches beyond the standard model based on the missing E{sub T} signature have not yet produced any positive results. Future prospects for the discovery of the top quark in the range m{sub top} < 200 GeV/c{sup 2} look promising. 80 refs., 35 figs., 7 tabs.

  11. LSND neutrino oscillation results

    SciTech Connect

    White, D.H.; LSND Collaboration

    1997-11-01

    The LSND experiment at Los Alamos has conducted a search for {anti v}{sub {mu}} {yields} {anti v}{sub e} oscillations using {anti v}{sub {mu}} from {mu}{sup +} decay at rest. The {anti v}{sub e} are detected via the reaction {anti v}{sub e} p {yields} e{sup +}n, correlated with the 2.2 MeV {gamma} from n p {yields} d {gamma}. The use of tight cuts to identify e{sup +} events with correlated {gamma} rays yielded 22 events with e{sup +} energy between 36 and 60 MeV and only 4.6 {+-} 0.6 background events. The probability that this excess is due entirely to a statistical fluctuation is 4.1 {times} 10{sup {minus}8}. A {chi}{sup 2} fit to the entire e{sup +} sample results in a total excess of 51.8{sub {minus}16.9}{sup +18.7} {+-} 8.0 events with e{sup +} energy between 20 and 60 MeV. If attributed to {anti v}{sub {mu}} {yields} {anti v}{sub e} oscillations, this corresponds to an oscillation probability (averaged over the experimental energy and spatial acceptance) of 0.31 {+-} 0.12 {+-} 0.05%.

  12. NAS Parallel Benchmarks Results

    NASA Technical Reports Server (NTRS)

    Subhash, Saini; Bailey, David H.; Lasinski, T. A. (Technical Monitor)

    1995-01-01

    The NAS Parallel Benchmarks (NPB) were developed in 1991 at NASA Ames Research Center to study the performance of parallel supercomputers. The eight benchmark problems are specified in a pencil and paper fashion i.e. the complete details of the problem to be solved are given in a technical document, and except for a few restrictions, benchmarkers are free to select the language constructs and implementation techniques best suited for a particular system. In this paper, we present new NPB performance results for the following systems: (a) Parallel-Vector Processors: Cray C90, Cray T'90 and Fujitsu VPP500; (b) Highly Parallel Processors: Cray T3D, IBM SP2 and IBM SP-TN2 (Thin Nodes 2); (c) Symmetric Multiprocessing Processors: Convex Exemplar SPP1000, Cray J90, DEC Alpha Server 8400 5/300, and SGI Power Challenge XL. We also present sustained performance per dollar for Class B LU, SP and BT benchmarks. We also mention NAS future plans of NPB.

  13. Simpler images, better results

    NASA Astrophysics Data System (ADS)

    Chance, Britton

    1999-03-01

    The very rapid development of optical technology has followed a pattern similar to that of nuclear magnetic resonance: first, spectroscopy and then imaging. The accomplishments in spectroscopy have been significant--among them, early detection of hematomas and quantitative oximetry (assuming that time and frequency domain instruments are used). Imaging has progressed somewhat later. The first images were obtained in Japan and USA a few years ago, particularly of parietal stimulation of the human brain. Since then, rapid applications to breast and limb, together with higher resolution of the brain now make NIR imaging of functional activation and tumor detection readily available, reliable and affordable devices. The lecture has to do with the applications of imaging to these three areas, particularly to prefrontal imaging of cognitive function, of breast tumor detection, and of localized muscle activation in exercise. The imaging resolution achievable in functional activation appears to be FWHM of 4 mm. The time required for an image is a few seconds or even much less. Breast image detection at 50 microsecond(s) ec/pixel results in images obtainable in a few seconds or shorter times (bandwidths of the kHz are available). Finally, imaging of the body organs is under study in this laboratory, particularly in the in utero fetus. It appears that the photon migration theory now leads to the development of a wide number of images for human subject tissue spectroscopy and imaging.

  14. SAA drift: Experimental results

    NASA Astrophysics Data System (ADS)

    Grigoryan, O. R.; Romashova, V. V.; Petrov, A. N.

    According to the paleomagnetic analysis there are variations of Earth’s magnetic field connected with magnetic moment changing. These variations affect on the South Atlantic Anomaly (SAA) location. Indeed different observations approved the existence of the SAA westward drift rate (0.1 1.0 deg/year) and northward drift rate (approximately 0.1 deg/year). In this work, we present the analysis of experimental results obtained in Scobeltsyn Institute of Nuclear Physics, Moscow State University (SINP MSU) onboard different Earth’s artificial satellites (1972 2003). The fluxes of protons with energy >50 MeV, gamma quanta with energy >500 keV and neutrons with energy 0.1 1.0 MeV in the SAA region have been analyzed. The mentioned above experimental data were obtained onboard the orbital stations Salut-6 (1979), MIR (1991, 1998) and ISS (2003) by the similar experimental equipment. The comparison of the data obtained during these two decades of investigations confirms the fact that the SAA drifts westward. Moreover the analysis of fluxes of electrons with energy about hundreds keV (Cosmos-484 (1972) and Active (Interkosmos-24, 1991) satellites) verified not only the SAA westward drift but northward drift also.

  15. CTF Challenge: Result Summary

    PubMed Central

    Marabini, Roberto; Carragher, Bridget; Chen, Shaoxia; Chen, James; Cheng, Anchi; Downing, Kenneth H.; Frank, Joachim; Grassucci, Robert A.; Heymann, J. Bernard; Jiang, Wen; Jonic, Slavica; Liao, Hstau Y.; Ludtke, Steven J.; Patwari, Shail; Piotrowski, Angela L.; Quintana, Adrian; Sorzano, Carlos O.S.; Stahlberg, Henning; Vargas, Javier; Voss, Neil R.; Chiu, Wah; Carazo, Jose M.

    2015-01-01

    Image formation in bright field electron microscopy can be described with the help of the contrast transfer function (CTF). In this work the authors describe the “CTF Estimation Challenge”, called by the Madrid Instruct Image Processing Center (I2PC) in collaboration with the National Center for Macromolecular Imaging (NCMI) at Houston. Correcting for the effects of the CTF requires accurate knowledge of the CTF parameters, but these have often been difficult to determine. In this challenge, researchers have had the opportunity to test their ability in estimating some of the key parameters of the electron microscope CTF on a large micrograph data set produced by well-known laboratories on a wide set of experimental conditions. This work presents the first analysis of the results of the CTF Estimation Challenge, including an assessment of the performance of the different software packages under different conditions, so as to identify those areas of research where further developments would be desirable in order to achieve high-resolution structural information. PMID:25913484

  16. ALOS-2 initial results

    NASA Astrophysics Data System (ADS)

    Kankaku, Yukihiro; Suzuki, Shinichi; Shimada, Masanobu

    2015-10-01

    The Advanced Land Observing Satellite-2 (ALOS-2) was launched from Tanegashima Space Center by H-IIA rocket successfully on 24th May 2014. ALOS-2 carries the Phased Array type L-band Synthetic Aperture Radar-2 (PALSAR-2) as the state-of-the-art L-band SAR system which succeeds to PALSAR onboard ALOS. PALSAR-2 uses almost whole bandwidth allocated for L-band active sensor of Earth Exploration Satellites Service specified by the Radio Regulation in order to realize the high resolution observation, and also, it transmits more than 6 kW power for lower Noise Equivalent Sigma Zero using 180 TRMs driven by Gallium Nitride (GaN) amplifier which is the first use in space. Furthermore, because ALOS-2 carries the SAR system only, PALSAR-2 antenna can be mounted under the satellite body. It enables to observe right-/left-looking observation by satellite maneuvering. And the high accuracy orbit control to maintain the satellite within 500 m radius tube against the reference orbit enables high coherence for the InSAR processing. Using these new technologies, ALOS-2 has been operating to fulfill the mission requirements such as disaster monitoring and so on. This document introduces the initial result of ALOS-2 from the first year operation.

  17. Overview of MAST results

    NASA Astrophysics Data System (ADS)

    Chapman, I. T.; Adamek, J.; Akers, R. J.; Allan, S.; Appel, L.; Asunta, O.; Barnes, M.; Ben Ayed, N.; Bigelow, T.; Boeglin, W.; Bradley, J.; Brünner, J.; Cahyna, P.; Carr, M.; Caughman, J.; Cecconello, M.; Challis, C.; Chapman, S.; Chorley, J.; Colyer, G.; Conway, N.; Cooper, W. A.; Cox, M.; Crocker, N.; Crowley, B.; Cunningham, G.; Danilov, A.; Darrow, D.; Dendy, R.; Diallo, A.; Dickinson, D.; Diem, S.; Dorland, W.; Dudson, B.; Dunai, D.; Easy, L.; Elmore, S.; Field, A.; Fishpool, G.; Fox, M.; Fredrickson, E.; Freethy, S.; Garzotti, L.; Ghim, Y. C.; Gibson, K.; Graves, J.; Gurl, C.; Guttenfelder, W.; Ham, C.; Harrison, J.; Harting, D.; Havlickova, E.; Hawke, J.; Hawkes, N.; Hender, T.; Henderson, S.; Highcock, E.; Hillesheim, J.; Hnat, B.; Holgate, J.; Horacek, J.; Howard, J.; Huang, B.; Imada, K.; Jones, O.; Kaye, S.; Keeling, D.; Kirk, A.; Klimek, I.; Kocan, M.; Leggate, H.; Lilley, M.; Lipschultz, B.; Lisgo, S.; Liu, Y. Q.; Lloyd, B.; Lomanowski, B.; Lupelli, I.; Maddison, G.; Mailloux, J.; Martin, R.; McArdle, G.; McClements, K.; McMillan, B.; Meakins, A.; Meyer, H.; Michael, C.; Militello, F.; Milnes, J.; Morris, A. W.; Motojima, G.; Muir, D.; Nardon, E.; Naulin, V.; Naylor, G.; Nielsen, A.; O'Brien, M.; O'Gorman, T.; Ono, Y.; Oliver, H.; Pamela, S.; Pangione, L.; Parra, F.; Patel, A.; Peebles, W.; Peng, M.; Perez, R.; Pinches, S.; Piron, L.; Podesta, M.; Price, M.; Reinke, M.; Ren, Y.; Roach, C.; Robinson, J.; Romanelli, M.; Rozhansky, V.; Saarelma, S.; Sangaroon, S.; Saveliev, A.; Scannell, R.; Schekochihin, A.; Sharapov, S.; Sharples, R.; Shevchenko, V.; Silburn, S.; Simpson, J.; Storrs, J.; Takase, Y.; Tanabe, H.; Tanaka, H.; Taylor, D.; Taylor, G.; Thomas, D.; Thomas-Davies, N.; Thornton, A.; Turnyanskiy, M.; Valovic, M.; Vann, R.; Walkden, N.; Wilson, H.; Wyk, L. V.; Yamada, T.; Zoletnik, S.; MAST; MAST Upgrade Teams

    2015-10-01

    The Mega Ampère Spherical Tokamak (MAST) programme is strongly focused on addressing key physics issues in preparation for operation of ITER as well as providing solutions for DEMO design choices. In this regard, MAST has provided key results in understanding and optimizing H-mode confinement, operating with smaller edge localized modes (ELMs), predicting and handling plasma exhaust and tailoring auxiliary current drive. In all cases, the high-resolution diagnostic capability on MAST is complemented by sophisticated numerical modelling to facilitate a deeper understanding. Mitigation of ELMs with resonant magnetic perturbations (RMPs) with toroidal mode number nRMP = 2, 3, 4, 6 has been demonstrated: at high and low collisionality; for the first ELM following the transition to high confinement operation; during the current ramp-up; and with rotating nRMP = 3 RMPs. nRMP = 4, 6 fields cause less rotation braking whilst the power to access H-mode is less with nRMP = 4 than nRMP = 3, 6. Refuelling with gas or pellets gives plasmas with mitigated ELMs and reduced peak heat flux at the same time as achieving good confinement. A synergy exists between pellet fuelling and RMPs, since mitigated ELMs remove fewer particles. Inter-ELM instabilities observed with Doppler backscattering are consistent with gyrokinetic simulations of micro-tearing modes in the pedestal. Meanwhile, ELM precursors have been strikingly observed with beam emission spectroscopy (BES) measurements. A scan in beta at the L-H transition shows that pedestal height scales strongly with core pressure. Gyro-Bohm normalized turbulent ion heat flux (as estimated from the BES data) is observed to decrease with increasing tilt of the turbulent eddies. Fast ion redistribution by energetic particle modes depends on density, and access to a quiescent domain with ‘classical’ fast ion transport is found above a critical density. Highly efficient electron Bernstein wave current drive (1 A W-1) has been achieved

  18. Inhibition of PMN-elastase activity by semisynthetic glucan sulfates.

    PubMed

    Becker, Markus; Franz, Gerhard; Alban, Susanne

    2003-05-01

    Proteolysis of connective tissue by enzymes such as PMN-elastase (PMNE) is a crucial step during inflammation and metastasis. Semisynthetic sulfated carbohydrates (SC) were shown to exhibit potent antiinflammatory and antimetastatic activity in vivo. The aim of the present study was to examine whether interferences with PMN-elastase may contribute to these effects. Therefore, the interactions of these compounds with PMNE were evaluated in various test systems. Besides semisynthetic alpha-1,4/1,6- and beta-1,3-glucan sulfates, UFH, a LMWH and pentosan polysulfate (PPS) were included in the study. The inhibitory activity of SC improves not only with increasing molecular weight (MW 10 - 250 kDa: 37 - 54% inhibition at 0.25 micro g/ml) and degree of sulfation (DS 0.25 - 2.0: 16 - 50% inhibition at 0.25 micro g/ml), but depends also on their genuine polysaccharide structure (IC50 beta-1,3-glucan sulfate 0.18 / alpha-1,4/1,6-glucan sulfate 0.25 / UFH 0.5 micro g/ml). Using physiological substrate assays (collagen, elastin), beta-1,3- and alpha-1,4/1,6-glucan sulfates are more active than UFH (inhibition at 1.5 micro g/ml: 41 / 32 / 12%). According to enzyme-inhibitor binding studies, SC exhibit structure dependent affinity to the enzyme (K(d) for PMNE: beta-1,3 < alpha-1,4/1,6 < UFH). Finally, SC were shown to inhibit cancer cell-mediated elastinolysis. PMID:12719790

  19. Angiopoietin-1 prevents severe bleeding complications induced by heparin-like drugs and fibroblast growth factor-2 in mice.

    PubMed

    Jerebtsova, Marina; Das, Jharna R; Tang, Pingtao; Wong, Edward; Ray, Patricio E

    2015-10-01

    Critically ill children can develop bleeding complications when treated with heparin-like drugs. These events are usually attributed to the anticoagulant activity of these drugs. However, previous studies showed that fibroblast growth factor-2 (FGF-2), a heparin-binding growth factor released in the circulation of these patients, could precipitate intestinal hemorrhages in mice treated with the heparin-like drug pentosan polysulfate (PPS). Yet very little is known about how FGF-2 induces bleeding complications in combination with heparin-like drugs. Here, we examined the mechanisms by which circulating FGF-2 induces intestinal hemorrhages in mice treated with PPS. We used a well-characterized mouse model of intestinal hemorrhages induced by FGF-2 plus PPS. Adult FVB/N mice were infected with adenovirus carrying Lac-Z or a secreted form of recombinant human FGF-2, and injected with PPS, at doses that do not induce bleeding complications per se. Mice treated with FGF-2 in combination with PPS developed an intestinal inflammatory reaction that increased the permeability and disrupted the integrity of submucosal intestinal vessels. These changes, together with the anticoagulant activity of PPS, induced lethal hemorrhages. Moreover, a genetically modified form of the endothelial ligand angiopoietin-1 (Ang-1*), which has powerful antipermeability and anti-inflammatory activity, prevented the lethal bleeding complications without correcting the anticoagulant status of these mice. These findings define new mechanisms through which FGF-2 and Ang-1* modulate the outcome of intestinal bleeding complications induced by PPS in mice and may have wider clinical implications for critically ill children treated with heparin-like drugs. PMID:26276817

  20. Expression of mutant and wild-type TIMP3 in primary gingival fibroblasts from Sorsby's fundus dystrophy patients.

    PubMed

    Arris, Christine E; Bevitt, Debra J; Mohamed, Jeseem; Li, Zheng; Langton, Kevin P; Barker, Michael D; Clarke, Michael P; McKie, Norman

    2003-05-20

    Gingival fibroblast cell lines were derived from Sorsby's fundus dystrophy (SFD) patients carrying the S181C TIMP3 and the E139X TIMP3 mutations. These cell lines were grown in culture to study expression of the wild-type and mutant tissue inhibitor of metalloproteinase 3 (TIMP3) alleles from a normal diploid cell type. Firstly, patient cells were found to co-express the wild-type and mutant TIMP3 alleles, S181C TIMP3 or E139X TIMP3, at the mRNA level using restriction fragment length polymorphism (RFLP) analysis. A SpeI RFLP for E139X TIMP3 is described. Low levels of endogenous TIMP3 protein expression were elevated using the natural polysaccharide calcium pentosan polysulfate (CaPPs) in combination with the cytokine IL-1alpha. Immunoblotting detected protein expression from both wild-type and mutant alleles, S181C TIMP3 or E139X TIMP3. S181C TIMP3 from these cells was found to dimerise and retain MMP2 inhibitory activity. To facilitate studies of the E139X TIMP3 protein, the allele was expressed using HighFive insect cells. In this cell type, the E139X TIMP3 was synthesised as a mixture of monomer and dimer. Both monomeric and dimeric E139X TIMP3 protein retained MMP2 inhibitory activity in gelatin zymography. Expression of mutant E139X or S181C TIMP3 protein from a normal diploid patient-derived fibroblast cell had no effect on either MMP2 or MMP9 expression or activation whilst transcribed from their normal promoter context. PMID:12757930

  1. RESULTATIVE VERBS AND OTHER PROBLEMS.

    ERIC Educational Resources Information Center

    HASHIMOTO, ANNE YUE

    THE SO-CALLED RESULTATIVE VERBS IN MANDARIN CHINESE ARE STUDIED WITHIN THE GENERAL FRAMEWORK OF A TRANSFORMATIONAL GRAMMAR. THE RESULTATIVE VERBS ARE GENERALLY CONSIDERED AS CONSISTING OF TWO COMPONENTS--A VERBAL COMPONENT FOLLOWED BY A RESULTATIVE OR DIRECTIONAL COMPLEMENT. OTHER PROBLEMS RELATED TO COMPLEMENTS ARE ALSO TOUCHED UPON, FOR EXAMPLE,…

  2. Paradoxical Results and Item Bundles

    ERIC Educational Resources Information Center

    Hooker, Giles; Finkelman, Matthew

    2010-01-01

    Hooker, Finkelman, and Schwartzman ("Psychometrika," 2009, in press) defined a paradoxical result as the attainment of a higher test score by changing answers from correct to incorrect and demonstrated that such results are unavoidable for maximum likelihood estimates in multidimensional item response theory. The potential for these results to…

  3. Aesthetic rhinoplasty: Avoiding unfavourable results.

    PubMed

    Bhangoo, Kulwant S

    2013-05-01

    Rhinoplasty is one of the most challenging surgical procedures in plastic surgery. It is not surprising that a significant number of patients end up with unfavourable outcomes. Many of these unfavourable outcomes could be the result of poor judgment and wrong decision making. Most frequently, the unfavourable outcome is the result of errors in surgical technique. In this paper, unfavourable outcomes resulting from errors in surgical technique are discussed under the heading of each operative step. Poor placement of intra-nasal incision can result in internal valve obstruction. Bad columellar scars can result from errors during open rhinoplasty. Unfavourable results associated with skeletonisation are mentioned. Tip plasty, being the most difficult part of rhinoplasty, can result in lack of tip projection, asymmetry and deformities associated with placement of tip grafts. Over-resection of the lower lateral cartilages during tip plasty can also result in pinched nose, alar collapse causing external valve obstruction and other alar rim deformities. Humpectomy can result in open roof deformity, inverted V deformity and over-resection resulting in saddle nose. The so-called poly beak deformity is also a preventable unfavourable outcome when dealing with a large dorsal hump. Complications resulting from osteotomies include narrowing of nasal airway, open roof deformity, inverted V deformity and asymmetry of the bony wall resulting from incomplete or green stick fractures. Judicious use of grafts can be very rewarding. By the same token, grafts also carry with them the risk of complications. Allografts can result in recurrent infection, atrophy of the overlying skin and extrusion resulting in crippling deformities. Autografts are recommended by the author. Unfavourable results from autografts include displacement of graft, visibility of the graft edges, asymmetry, warping, and resorption. PMID:24501471

  4. Misleading biochemical laboratory test results

    PubMed Central

    Nanji, Amin A.

    1984-01-01

    This article reviews the general and specific factors that interfere with the performance of common biochemical laboratory tests and the interpretation of their results. The clinical status of the patient, drug interactions, and in-vivo and in-vitro biochemical interactions and changes may alter the results obtained from biochemical analysis of blood constituents. Failure to recognize invalid laboratory test results may lead to injudicious and dangerous management of patients. PMID:6375845

  5. Latest Electroweak Results from CDF

    SciTech Connect

    Lancaster, Mark

    2010-05-01

    The latest results in electroweak physics from proton anti-proton collisions at the Fermilab Tevatron recorded by the CDF detector are presented. The results provide constraints on parton distribution functions, the mass of the Higgs boson and beyond the Standard Model physics.

  6. Top physics results at CDF

    SciTech Connect

    Vickey, Trevor; /Illinois U., Urbana

    2005-05-01

    The most recent results on top quark physics at CDF are reported. Measurements of cross-section and mass are presented, and the status of single top quark production searches are discussed. The results obtained from probing various top quark properties are also presented.

  7. Measurement Services Association Questionnaire Results.

    ERIC Educational Resources Information Center

    Wood, Lewis J.; Gillis, Rod

    This paper presents the results of a questionnaire sent to 211 Measurement Services Association members. Sixty-four centers responded. The main purpose of the questionnaire was to find out what hardware and software are used by testing centers throughout the country. Results indicate that 52 institutions use mainframe computers, 50 use…

  8. Site Testing Results and Automation

    NASA Astrophysics Data System (ADS)

    Ashley, Michael M.; Storey, John W.; Burton, Michael G.

    NOTE: this is highly preliminary just to get the abstract in by the deadline! - brief summary of the AASTO program - key points from the site testing results at South Pole - very brief introduction to ICECAM and the AASTINO - key results from ICECAM and the AASTINO instruments - next year's instrument plans at South Pole and Dome C including a brief mention of Doug Caldwell's experiment

  9. FORWARD PHYSICS AND BRAHMS RESULTS.

    SciTech Connect

    DEBBE, R.

    2005-02-03

    We report here the BRAHMS measurements of particle production in d+Au and p+p collisions at RHIC. The results presented here are compared to previous p+A measurements at lower energies in fixed target mode. Some preliminary results on abundances of identified particles at high rapidity are also presented.

  10. MER ARA pyroshock test results

    NASA Technical Reports Server (NTRS)

    Chang, Kurng Y.

    2004-01-01

    This paper presents the shock test results achieved in the MER ARA/brush motor pyroshock qualification. The results of MER flight system pyrofiring tests in comparison with the ARA shock test requirements are discussed herein. Alternate test methods were developed in an effort to qualify the critical MER equipment for adequate performance in the actual flight pyroshock condition.

  11. [The "incorrect" laboratory result. II: Common misinterpretations of laboratory results].

    PubMed

    Thiery, J; Fiedler, G M

    2004-04-01

    In the second part of our review the most frequent misinterpretations of laboratory results in the daily clinical practise are discussed. Special attention has been given to frequent misinterpretations in the analysis of electrolytes, enzymes and hormones in plasma/serum (pseudohyperkalemia, macroenzymes, macroprolactinemia). Misinterpretations of the testing of blood gases, serum glucose, lipid concentrations, and calcium are described in greater detail. In addition, potential errors in the urinanalysis and the importance of adequate sampling of blood specimens for coagulation testing are described. The hematological results can be misinterpreted in the presence of EDTA-induced pseudothrombocytenia and of irregular immunoglobulines. Immunological methods themselves can lead to misinterpretations of the laboratory result, e. g. caused by the high dose hook effect and interferences in the presence of rheumatoid factor or HAMA. Finally clinical relevant errors in the therapeutic drug monitoring are discussed which are associated with the limited specificity of the antibodies in the commonly used immunological tests. PMID:15151138

  12. Spacelab Life Sciences 1 results

    NASA Technical Reports Server (NTRS)

    Seddon, Rhea

    1992-01-01

    Results are presented from the experiments conducted by the first Shuttle/Spacelab mission dedicated entirely to the life sciences, the Spacelab Life Sciences 1, launched on June 5, 1991. The experiments carried out during the 9-day flight included investigations of changes in the human cardiovascular, pulmonary, renal/endocrine, blood, and vestibular systems that were brought about by microgravity. Results were also obtained from the preflight and postflight complementary experiments performed on rats, which assessed the suitability of rodents as animal models for humans. Most results verified, or expanded on, the accepted theories of adaptation to zero gravity.

  13. Pentaquarks: the latest experimental results

    SciTech Connect

    M. Battaglieri; R. De Vita; Valery Kubarovsky

    2006-01-01

    After the claim of the possible discovery of a pentaquark state, many experiments reported positive and negative results opening a discussion about the pentaquark existence. New experiments with high resolution and high statistics are needed in the reaction channels and for the kinematics of the positive results to solve the controversy. Jefferson Lab started a comprehensive program to search for pentaquark in photoproduction at threshold on proton and deuteron targets, collecting more than 10 times the existing statistics. The first experiment on the proton (g11) just finished to analyze the data, and the first results of the pentaquark search are reported here.

  14. Some recent results from ICARUS

    SciTech Connect

    Farnese, Christian

    2015-07-15

    ICARUS T600 is the largest Liquid Argon (LAr) Time Projection Chamber (TPC) ever built. Thanks to the excellent spatial and calorimetric resolutions and the three-dimensional visualization capabilities ICARUS T600 represents a major milestone towards the realization of future LAr detectors for neutrino physics and for the search of rare events. Three new important results from the analysis of the events collected by this detector will be here shortly presented: in particular the new improved results on the electron neutrino search, the results on the determination of the muon momentum using the Multiple Scattering and the new LAr purification methods and improvements of the electron lifetime.

  15. Contradictory results in interferon research

    NASA Technical Reports Server (NTRS)

    Sonnenfeld, G.

    1984-01-01

    Several reports on immunologically related interferon research, both in the areas of basic science and clinical research, are briefly reviewed, and it is noted that in many cases the results obtained are contradictory. It is argued, however, that the contradictory results are not surprising since interferon is a biological response modifier and has been known to produce opposite results even when the same interferon prepartion is used. It is emphasized that dosage, timing, route, and other experimental conditions are essential factors in planning immunological studies with interferon. Careful planning of future experiments with interferon should be required to prevent the possible generation of effects that are opposite to those expected.

  16. Results of Neptunium Disposal Testing

    SciTech Connect

    Walker, D.D.

    2003-10-07

    Researchers investigated the neutralization of neptunium solution from H-Canyon Tank 16.4 and the properties of the resulting slurry. This work investigated slurry properties from a single neutralization protocol and limited storage times.

  17. Interpreting Results from Multiscore Batteries.

    ERIC Educational Resources Information Center

    Anastasi, Anne

    1985-01-01

    Describes the role of information on score reliabilities, significance of score differences, intercorrelations of scores, and differential validity of score patterns on the interpretation of results from multiscore batteries. (Author)

  18. Results from Neutrino Oscillations Experiments

    SciTech Connect

    Aguilar-Arevalo, Alexis

    2010-09-10

    The interpretation of the results of early solar and atmospheric neutrino experiments in terms of neutrino oscillations has been verified by several recent experiments using both, natural and man-made sources. The observations provide compelling evidence in favor of the existence of neutrino masses and mixings. These proceedings give a general description of the results from neutrino oscillation experiments, the current status of the field, and some possible future developments.

  19. Electroweak results from the tevatron

    SciTech Connect

    Wood, D.

    1997-01-01

    Electroweak results are presented from the CDF and DO experiments based on data collected in recent runs of the Fermilab Tevatron Collider. The measurements include the mass and width of the W boson, the production cross sections of the W and Z bosons, and the W charge asymmetry. Additional results come from studies of events with pairs of electroweak gauge bosons and include limits on anomalous couplings.

  20. Analysis of EUVE Experiment Results

    NASA Technical Reports Server (NTRS)

    Horan, Stephen

    1996-01-01

    A series of tests to validate an antenna pointing concept for spin-stabilized satellites using a data relay satellite are described. These tests show that proper antenna pointing on an inertially-stabilized spacecraft can lead to significant access time through the relay satellite even without active antenna pointing. We summarize the test results, the simulations to model the effects of antenna pattern and space loss, and the expected contact times. We also show how antenna beam width affects the results.

  1. New CDF results on diffraction

    SciTech Connect

    Mesropian, Christina; /Rockefeller U.

    2006-12-01

    We report new diffraction results obtained by the CDF collaboration in proton-antiproton collisions at the Fermilab Tevatron collider at {radical}s=1.96 TeV. The first experimental evidence of exclusive dijet and diphoton production is presented. The exclusive results are discussed in context of the exclusive Higgs production at LHC. We also present the measurement of the Q{sup 2} and t dependence of the diffractive structure function.

  2. Catastrophic disruption experiments: Recent results

    NASA Technical Reports Server (NTRS)

    Martelli, G.; Ryan, E. V.; Nakamura, A. M.; Giblin, I.

    1994-01-01

    This paper presents a review of the progress in the field of catastrophic disruption experiments over the past 4 years, since the publication of the review paper by Fujiwara et al. (1989). We describe the development of new techniques to produce shattering impacts relevant to the study of the collisional evolution of the asteroids, and summarize the results from numerous experiments which have been performed to date, using a variety of materials for both the impactor and the targets. Some of these, such as ice-on-ice, loose aggregates and pressurized targets, are quite new and have provided novel and exciting results. Some of the gaps existing previously in the data on fragment ejection-angle distributions, as well as translational and rotational velocity fields (including fine fragments) have been filled, and these new results will be surveyed.

  3. ACTS: Technology Description and Results

    NASA Technical Reports Server (NTRS)

    Gedney, Richard T.; Schertler, Ronald; Gargione, Frank

    2000-01-01

    The ACTS Project was originated at NASA Glenn Research Center in the early 1980's to sponsor the development and application of technology that was intended to be used by the private sector. The program was formulated with the underlying philosophy of maintaining US leadership in satellite communications while focusing technology development for efficient use of the frequency spectrum. This report chronicles the execution and results of the program from the perspective of its technology managers, from inception through hardware and system development to on-orbit experiments and demonstrations of the technology. The first eight sections of the report discuss programmatic background, the specific satellite and ground terminal technology and the results generated by the program including industry relevance. A federally funded program of this type attracted strong advocates and adversaries and the resulting impact on the project schedule is also discussed. The last two sections are a list of useful acronyms and extensive references.

  4. New NAS Parallel Benchmarks Results

    NASA Technical Reports Server (NTRS)

    Yarrow, Maurice; Saphir, William; VanderWijngaart, Rob; Woo, Alex; Kutler, Paul (Technical Monitor)

    1997-01-01

    NPB2 (NAS (NASA Advanced Supercomputing) Parallel Benchmarks 2) is an implementation, based on Fortran and the MPI (message passing interface) message passing standard, of the original NAS Parallel Benchmark specifications. NPB2 programs are run with little or no tuning, in contrast to NPB vendor implementations, which are highly optimized for specific architectures. NPB2 results complement, rather than replace, NPB results. Because they have not been optimized by vendors, NPB2 implementations approximate the performance a typical user can expect for a portable parallel program on distributed memory parallel computers. Together these results provide an insightful comparison of the real-world performance of high-performance computers. New NPB2 features: New implementation (CG), new workstation class problem sizes, new serial sample versions, more performance statistics.

  5. [Submitting studies without significant results].

    PubMed

    Texier, Gaëtan; Meynard, Jean-Baptiste; Michel, Rémy; Migliani, René; Boutin, Jean-Paul

    2007-03-01

    When a study finds that no exposure factor or therapy is significantly related to a given effect, researchers legitimately wonder if the results should be submitted for publication and to what journal. Clinical trials that report significant associations have a higher probability of publication, a phenomenon known as selective publication. The principal reasons of this selective publication include author self-censorship, peer-reviewing, trials not intended for publication, interpretation of the p value, cost of journal subscriptions, and policies. Subsequent reviews and meta-analyses are biased by the unavailability of nonsignificant results. Suggestions for preventing this risk include university training, trial registries, an international standard randomised controlled trial number (ISRCTN), Cochrane collaboration, and the gray literature. Journals (including electronic journals) interested in studies with nonsignificant results are listed. New technologies are changing the relations between publishers, libraries, authors and readers. PMID:17287106

  6. New results from FRECOPA analysis

    NASA Technical Reports Server (NTRS)

    Durin, Christian

    1993-01-01

    New results from the ongoing analysis of the FRECOPA's (FREnch COoperative PAssive payload) system hardware are discussed. FRECOPA (AO138) was one of the 57 experiments flown on the LDEF satellite. The experiment was located on the trailing edge (Tray B3) and was exposed to UV radiation (11,100 equivalent sun hours), approximately equal to 34,000 thermal cycles, higher vacuum levels than the leading edge, a low atomic oxygen flux, and minor doses of protons and electrons. Due to LDEF's extended mission (5.8 years), CNES decided to set up a team to analyze the FRECOPA system. Initial results were presented at the First Post-Retrieval Conference, June, 1991. The results obtained since then are summarized.

  7. Data Mining Citizen Science Results

    NASA Astrophysics Data System (ADS)

    Borne, K. D.

    2012-12-01

    Scientific discovery from big data is enabled through multiple channels, including data mining (through the application of machine learning algorithms) and human computation (commonly implemented through citizen science tasks). We will describe the results of new data mining experiments on the results from citizen science activities. Discovering patterns, trends, and anomalies in data are among the powerful contributions of citizen science. Establishing scientific algorithms that can subsequently re-discover the same types of patterns, trends, and anomalies in automatic data processing pipelines will ultimately result from the transformation of those human algorithms into computer algorithms, which can then be applied to much larger data collections. Scientific discovery from big data is thus greatly amplified through the marriage of data mining with citizen science.

  8. Planck 2013 results. I. Overview of products and scientific results

    NASA Astrophysics Data System (ADS)

    Planck Collaboration; Ade, P. A. R.; Aghanim, N.; Alves, M. I. R.; Armitage-Caplan, C.; Arnaud, M.; Ashdown, M.; Atrio-Barandela, F.; Aumont, J.; Aussel, H.; Baccigalupi, C.; Banday, A. J.; Barreiro, R. B.; Barrena, R.; Bartelmann, M.; Bartlett, J. G.; Bartolo, N.; Basak, S.; Battaner, E.; Battye, R.; Benabed, K.; Benoît, A.; Benoit-Lévy, A.; Bernard, J.-P.; Bersanelli, M.; Bertincourt, B.; Bethermin, M.; Bielewicz, P.; Bikmaev, I.; Blanchard, A.; Bobin, J.; Bock, J. J.; Böhringer, H.; Bonaldi, A.; Bonavera, L.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Boulanger, F.; Bourdin, H.; Bowyer, J. W.; Bridges, M.; Brown, M. L.; Bucher, M.; Burenin, R.; Burigana, C.; Butler, R. C.; Calabrese, E.; Cappellini, B.; Cardoso, J.-F.; Carr, R.; Carvalho, P.; Casale, M.; Castex, G.; Catalano, A.; Challinor, A.; Chamballu, A.; Chary, R.-R.; Chen, X.; Chiang, H. C.; Chiang, L.-Y.; Chon, G.; Christensen, P. R.; Churazov, E.; Church, S.; Clemens, M.; Clements, D. L.; Colombi, S.; Colombo, L. P. L.; Combet, C.; Comis, B.; Couchot, F.; Coulais, A.; Crill, B. P.; Cruz, M.; Curto, A.; Cuttaia, F.; Da Silva, A.; Dahle, H.; Danese, L.; Davies, R. D.; Davis, R. J.; de Bernardis, P.; de Rosa, A.; de Zotti, G.; Déchelette, T.; Delabrouille, J.; Delouis, J.-M.; Démoclès, J.; Désert, F.-X.; Dick, J.; Dickinson, C.; Diego, J. M.; Dolag, K.; Dole, H.; Donzelli, S.; Doré, O.; Douspis, M.; Ducout, A.; Dunkley, J.; Dupac, X.; Efstathiou, G.; Elsner, F.; Enßlin, T. A.; Eriksen, H. K.; Fabre, O.; Falgarone, E.; Falvella, M. C.; Fantaye, Y.; Fergusson, J.; Filliard, C.; Finelli, F.; Flores-Cacho, I.; Foley, S.; Forni, O.; Fosalba, P.; Frailis, M.; Fraisse, A. A.; Franceschi, E.; Freschi, M.; Fromenteau, S.; Frommert, M.; Gaier, T. C.; Galeotta, S.; Gallegos, J.; Galli, S.; Gandolfo, B.; Ganga, K.; Gauthier, C.; Génova-Santos, R. T.; Ghosh, T.; Giard, M.; Giardino, G.; Gilfanov, M.; Girard, D.; Giraud-Héraud, Y.; Gjerløw, E.; González-Nuevo, J.; Górski, K. M.; Gratton, S.; Gregorio, A.; Gruppuso, A.; Gudmundsson, J. E.; Haissinski, J.; Hamann, J.; Hansen, F. K.; Hansen, M.; Hanson, D.; Harrison, D. L.; Heavens, A.; Helou, G.; Hempel, A.; Henrot-Versillé, S.; Hernández-Monteagudo, C.; Herranz, D.; Hildebrandt, S. R.; Hivon, E.; Ho, S.; Hobson, M.; Holmes, W. A.; Hornstrup, A.; Hou, Z.; Hovest, W.; Huey, G.; Huffenberger, K. M.; Hurier, G.; Ilić, S.; Jaffe, A. H.; Jaffe, T. R.; Jasche, J.; Jewell, J.; Jones, W. C.; Juvela, M.; Kalberla, P.; Kangaslahti, P.; Keihänen, E.; Kerp, J.; Keskitalo, R.; Khamitov, I.; Kiiveri, K.; Kim, J.; Kisner, T. S.; Kneissl, R.; Knoche, J.; Knox, L.; Kunz, M.; Kurki-Suonio, H.; Lacasa, F.; Lagache, G.; Lähteenmäki, A.; Lamarre, J.-M.; Langer, M.; Lasenby, A.; Lattanzi, M.; Laureijs, R. J.; Lavabre, A.; Lawrence, C. R.; Le Jeune, M.; Leach, S.; Leahy, J. P.; Leonardi, R.; León-Tavares, J.; Leroy, C.; Lesgourgues, J.; Lewis, A.; Li, C.; Liddle, A.; Liguori, M.; Lilje, P. B.; Linden-Vørnle, M.; Lindholm, V.; López-Caniego, M.; Lowe, S.; Lubin, P. M.; Macías-Pérez, J. F.; MacTavish, C. J.; Maffei, B.; Maggio, G.; Maino, D.; Mandolesi, N.; Mangilli, A.; Marcos-Caballero, A.; Marinucci, D.; Maris, M.; Marleau, F.; Marshall, D. J.; Martin, P. G.; Martínez-González, E.; Masi, S.; Massardi, M.; Matarrese, S.; Matsumura, T.; Matthai, F.; Maurin, L.; Mazzotta, P.; McDonald, A.; McEwen, J. D.; McGehee, P.; Mei, S.; Meinhold, P. R.; Melchiorri, A.; Melin, J.-B.; Mendes, L.; Menegoni, E.; Mennella, A.; Migliaccio, M.; Mikkelsen, K.; Millea, M.; Miniscalco, R.; Mitra, S.; Miville-Deschênes, M.-A.; Molinari, D.; Moneti, A.; Montier, L.; Morgante, G.; Morisset, N.; Mortlock, D.; Moss, A.; Munshi, D.; Murphy, J. A.; Naselsky, P.; Nati, F.; Natoli, P.; Negrello, M.; Nesvadba, N. P. H.; Netterfield, C. B.; Nørgaard-Nielsen, H. U.; North, C.; Noviello, F.; Novikov, D.; Novikov, I.; O'Dwyer, I. J.; Orieux, F.; Osborne, S.; O'Sullivan, C.; Oxborrow, C. A.; Paci, F.; Pagano, L.; Pajot, F.; Paladini, R.; Pandolfi, S.; Paoletti, D.; Partridge, B.; Pasian, F.; Patanchon, G.; Paykari, P.; Pearson, D.; Pearson, T. J.; Peel, M.; Peiris, H. V.; Perdereau, O.; Perotto, L.; Perrotta, F.; Pettorino, V.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Pietrobon, D.; Plaszczynski, S.; Platania, P.; Pogosyan, D.; Pointecouteau, E.; Polenta, G.; Ponthieu, N.; Popa, L.; Poutanen, T.; Pratt, G. W.; Prézeau, G.; Prunet, S.; Puget, J.-L.; Pullen, A. R.; Rachen, J. P.; Racine, B.; Rahlin, A.; Räth, C.; Reach, W. T.; Rebolo, R.; Reinecke, M.; Remazeilles, M.; Renault, C.; Renzi, A.; Riazuelo, A.; Ricciardi, S.; Riller, T.; Ringeval, C.; Ristorcelli, I.; Robbers, G.; Rocha, G.; Roman, M.; Rosset, C.; Rossetti, M.; Roudier, G.; Rowan-Robinson, M.; Rubiño-Martín, J. A.; Ruiz-Granados, B.; Rusholme, B.

    2014-11-01

    The European Space Agency's Planck satellite, dedicated to studying the early Universe and its subsequent evolution, was launched 14 May 2009 and has been scanning the microwave and submillimetre sky continuously since 12 August 2009. In March 2013, ESA and the Planck Collaboration released the initial cosmology products based on the first 15.5 months of Planck data, along with a set of scientific and technical papers and a web-based explanatory supplement. This paper gives an overview of the mission and its performance, the processing, analysis, and characteristics of the data, the scientific results, and the science data products and papers in the release. The science products include maps of the cosmic microwave background (CMB) and diffuse extragalactic foregrounds, a catalogue of compact Galactic and extragalactic sources, and a list of sources detected through the Sunyaev-Zeldovich effect. The likelihood code used to assess cosmological models against the Planck data and a lensing likelihood are described. Scientific results include robust support for the standard six-parameter ΛCDM model of cosmology and improved measurements of its parameters, including a highly significant deviation from scale invariance of the primordial power spectrum. The Planck values for these parameters and others derived from them are significantly different from those previously determined. Several large-scale anomalies in the temperature distribution of the CMB, first detected by WMAP, are confirmed with higher confidence. Planck sets new limits on the number and mass of neutrinos, and has measured gravitational lensing of CMB anisotropies at greater than 25σ. Planck finds no evidence for non-Gaussianity in the CMB. Planck's results agree well with results from the measurements of baryon acoustic oscillations. Planck finds a lower Hubble constant than found in some more local measures. Some tension is also present between the amplitude of matter fluctuations (σ8) derived from

  9. Spaghetti calorimeter results and prospects

    SciTech Connect

    Desalvo, R.

    1992-12-31

    In the guidelines of the SPACAL-LAA project the authors have built and beam-tested a prototype of spaghetti calorimeter with full hadronic shower containment. The results proved that the spaghetti technology (lead and scintillating fibers) can perform very accurate calorimetric measurements at the 15 ns LHC or SSC crossing rate and can compete with advantage over the other calorimetric technologies. In this paper they present the experimental results obtained so far and some future development foreseen in view of a hermetic supercollider detector.

  10. Supersymmetry results at the Tevatron

    SciTech Connect

    Manca, Giulia; /Liverpool U.

    2005-05-01

    The Run II physics programme of the Tevatron is proceeding with more than 300 pb{sup -1} of analysis quality data, collected at a center-of-mass energy of 1.96 TeV. Searches for supersymmetric particles are starting to set new limits, improving over the LEP and Run I results and exploring new regions of parameter space. They present recent results in Supersymmetry with the upgraded CDF and D0 detectors and give some prospects for the future of these searches.

  11. Improved non-approximability results

    SciTech Connect

    Bellare, M.; Sudan, M.

    1994-12-31

    We indicate strong non-approximability factors for central problems: N{sup 1/4} for Max Clique; N{sup 1/10} for Chromatic Number; and 66/65 for Max 3SAT. Underlying the Max Clique result is a proof system in which the verifier examines only three {open_quotes}free bits{close_quotes} to attain an error of 1/2. Underlying the Chromatic Number result is a reduction from Max Clique which is more efficient than previous ones.

  12. Tau physics results from SLD

    SciTech Connect

    Daoudi, M.; SLD Collaboration

    1996-08-10

    Results on {tau} physics at SLD are presented. They are based on 4,316 {tau}-pair events selected from a 150 k Z{sup 0} data sample collected at the SLC. These results include measurements of the {tau} lifetime ({tau}{sub r} = 288.1 {+-} 6.1 {+-} 3.3 fs), the {tau} Michel parameters ({rho} = 0.71 {+-} 0.09 {+-} 0.04, {zeta} = 1.03 {+-} 0.36 {+-} 0.05, and {zeta}{delta} = 0.84 {+-} 0.27 {+-} 0.05), and the {tau} neutrino helicity (h{sub {nu}} = {minus}0.81 {+-} 0.18 {+-} 0.03).

  13. Results from Numerical General Relativity

    NASA Technical Reports Server (NTRS)

    Baker, John G.

    2011-01-01

    For several years numerical simulations have been revealing the details of general relativity's predictions for the dynamical interactions of merging black holes. I will review what has been learned of the rich phenomenology of these mergers and the resulting gravitational wave signatures. These wave forms provide a potentially observable record of the powerful astronomical events, a central target of gravitational wave astronomy. Asymmetric radiation can produce a thrust on the system which may accelerate the single black hole resulting from the merger to high relative velocity.

  14. Communicating Performance Assessments Results - 13609

    SciTech Connect

    Layton, Mark

    2013-07-01

    The F-Area Tank Farms (FTF) and H-Area Tank Farm (HTF) are owned by the U.S. Department of Energy (DOE) and operated by Savannah River Remediation LLC (SRR), Liquid Waste Operations contractor at DOE's Savannah River Site (SRS). The FTF and HTF are active radioactive waste storage and treatment facilities consisting of 51 carbon steel waste tanks and ancillary equipment such as transfer lines, evaporators and pump tanks. Performance Assessments (PAs) for each Tank Farm have been prepared to support the eventual closure of the underground radioactive waste tanks and ancillary equipment. PAs provide the technical bases and results to be used in subsequent documents to demonstrate compliance with the pertinent requirements for final closure of the Tank Farms. The Tank Farms are subject to a number of regulatory requirements. The State regulates Tank Farm operations through an industrial waste water permit and through a Federal Facility Agreement approved by the State, DOE and the Environmental Protection Agency (EPA). Closure documentation will include State-approved Tank Farm Closure Plans and tank-specific closure modules utilizing information from the PAs. For this reason, the State of South Carolina and the EPA must be involved in the performance assessment review process. The residual material remaining after tank cleaning is also subject to reclassification prior to closure via a waste determination pursuant to Section 3116 of the Ronald W. Reagan National Defense Authorization Act of Fiscal Year 2005. PAs are performance-based, risk-informed analyses of the fate and transport of FTF and HTF residual wastes following final closure of the Tank Farms. Since the PAs serve as the primary risk assessment tools in evaluating readiness for closure, it is vital that PA conclusions be communicated effectively. In the course of developing the FTF and HTF PAs, several lessons learned have emerged regarding communicating PA results. When communicating PA results it is

  15. CDF results on electroweak physics

    SciTech Connect

    Frisch, H.J.; CDF Collaboration

    1993-11-01

    The second major run of the {bar p}p Fermilab Tevatron collider has just ended on June 1. The CDF detector has accumulated almost five times the data sample of its previous 1988--1989 run. We present new results on the ratio of W to Z boson production cross-sections and on the charge asymmetry in W decay. We give a progress report on the measurement of the W mass. New results from the 1988--1989 data on Drell-Yan production and on W {gamma} production are also presented.

  16. Recent CMS results on diffraction

    NASA Astrophysics Data System (ADS)

    Benoît, Roland

    2015-03-01

    Recent CMS results on diffraction are presented. These include the measurements of the soft diffractive cross sections, of the forward rapidity gap cross section, of the diffractive dijet cross section, the measurement of a large rapidity gap in W and Z boson events and the measurement of the pseudorapidity distribution of charged particles in a single diffractive enhanced sample. This last measurement is the first common result of the CMS and TOTEM collaborations. Some prospects of common CMS-TOTEM data taking are also discussed.

  17. First results from SAGE II

    SciTech Connect

    Abdurashitov, J.N.; Faizov, E.L.; Gavrin, V.N.

    1994-07-01

    The Russian-American Gallium solar neutrino Experiment (SAGE) began the second phase of operation (SAGE II) in September of 1992. Monthly measurements of the integral flux of solar neutrinos have been made with 55 tonnes of gallium. The K-peak results of the first five runs of SAGE II give a capture rate of 76{sub {minus}18}{sup +21} (stat) {sub {minus}7}{sup +5} (sys) SNU. combined with the SAGE I result, the capture rate is 74{sub {minus}12}{sup +13} (stat) {sub {minus}7}{sup +5} (sys) SNU. This represents only 56%--60% of the capture rate predicted by different Standard Solar Models.

  18. The Planck Mission: Early Results

    SciTech Connect

    Marco Bersanelli

    2012-03-07

    The ESA Planck space mission, launched on May 14, 2009, is dedicated to high precision measurements of the cosmic microwave background (CMB), the first light of the universe, both in temperature and polarization. The satellite observes the full sky from a far-Earth orbit with two cryogenic instruments in the 30-850 GHz range at the focal plane of a 1.5-meter telescope. The primary objective of Planck is to measure with unprecedented precision the key cosmological parameters and to provide accurate tests of physics in the early universe. Planck has recently completed the fifth full-sky survey. The data analysis is underway. The first cosmology results are expected in early 2013 while a number of astrophysical results have been recently delivered to the community, including galactic and extragalactic astrophysics and a rich catalogue of radio and infrared sources. These results demonstrate the excellent in-orbit performance of the instruments and give excellent prospects for the forthcoming cosmological results.

  19. Recent Results from the Tevatron

    SciTech Connect

    Demorden, L.

    1998-06-01

    We review recent results from fixed-target and collider experiments at the Fermilab Tevatron. Among the topics discussed are jet production rates, {alpha}{sub S} measurements, the {anti d}/{anti u} ratio in the proton sea, diffraction, heavy quark physics and leptoquark searches.

  20. Results of Computer Based Training.

    ERIC Educational Resources Information Center

    1978

    This report compares the projected savings of using computer based training to conduct training for newly hired pilots to the results of that application. New Hire training, one of a number of programs conducted continuously at the United Airline Flight Operations Training Center, is designed to assure that any newly hired pilot will be able to…

  1. The Latest Results from DAMPE

    NASA Astrophysics Data System (ADS)

    Chang, Jin

    2016-07-01

    DArk Matter Particle Explorer (DAMPE) successfully launched on Dec.17, 2015 is the first Chinese astronomical satellite that can measure 2 GeV-10 TeV electrons and gamma-rays with unprecedented energy resolution. In this talk I will introduce the design, the beam-test, the on-orbit calibration and some preliminary results of DAMPE.

  2. State Test Results Are Predictable

    ERIC Educational Resources Information Center

    Tienken, Christopher H.

    2014-01-01

    Out-of-school, community demographic and family-level variables have an important influence on student achievement as measured by large-scale standardized tests. Studies described here demonstrated that about half of the test score is accounted for by variables outside the control of teachers and school administrators. The results from these…

  3. Perseids 2006 results in Romania

    NASA Astrophysics Data System (ADS)

    Grigore, Valentin; Berinde, Stefan; Conu, Alexandru

    2007-12-01

    The results of 14th edition of the Perseide (Perseid) project organized by SARM are presented. PERSEIDE 2006 - the national astronomical camp for yought had two distinct parts: a summer astronomical school and a national Perseid network. Over 60 persons attended this event which lasted for four weeks and had both a training and observing component.

  4. Block Scheduling that Gets Results

    ERIC Educational Resources Information Center

    Myers, Nicholas J.

    2008-01-01

    All children can learn. When principals and faculties fully embrace this core belief and demonstrate it to students, parents, and each other, significant improvements in academic performance can result. However, while it is certainly true that all children are capable of academic success, it is also true that learning occurs at different rates.…

  5. FFTF startup: status and results

    SciTech Connect

    Noordhoff, B.H.; Moore, C.E.

    1980-03-01

    Startup testing on the Fast Flux Test Facility (FFTF) during the past three years has progressed beyond initial criticality toward the principal goal of power demonstration in 1980. An overview is presented of technical results to date and project plans to achieve power demonstration and complete the startup test program.

  6. Results from the HARP experiment

    NASA Astrophysics Data System (ADS)

    Radicioni, E.

    2008-07-01

    Hadron production is a key ingredient for precise prediction of atmospheric ν fluxes, characterization of accelerator ν beams, and quantification of π production and capture for ν-factory designs. HARP at the CERN PS was the first hadron production experiment designed on purpose to match all these requirements. We briefly describe here its most recent results.

  7. Recent results from DORIS II

    SciTech Connect

    Bloom, E.D.

    1985-01-01

    This report contains a brief review of recent results from the ARGUS and Crystal Ball experiments at DORIS II, concentrating on UPSILON(1S) and UPSILON(2S) spectroscopy with a short foray into ..gamma gamma.. physics. 18 refs., 10 figs.

  8. First Results of Submillimeter Polarimetry

    NASA Technical Reports Server (NTRS)

    Hildebrand, R. H.; Dragovan, M.; Novak, G.

    1984-01-01

    Airborne results of submillimeter polarization at one wavelength, 270 micro m for just three points in the sky are presented. Polarizations of 1.7% at each of two points in Orion are shown. A null result at 400 micro m from ground-based observations of Mars at opposition is also presented. A null result for W3(OH) is given. The Kleinmann-Low Nebula (KL) was chosen for one of the measurements because it is bright and polarization had been observed 10 micro m. Airborne results of submillimeter polarimetry indicate that: (1) Cool, dense interstellar clouds can emit polarized submillimeter radiation; (2) The direction of the magnetic field, averaged over the 90 beams, is the same for the Kleinmann-Low Nebula and the 400 micro m peak 1.5 south of the Nebula; and (3) The effectiveness of the grain alignment mechanism, averaged over the 90 beams, is the same for the Kleinmann-Low Nebula and the 400 micro m peak.

  9. Recent diffractive results from HERA

    NASA Astrophysics Data System (ADS)

    Valkárová, Alice

    2016-07-01

    The diffractive dijet cross sections for photoproduction and deep inelastic scattering were studied and compared with theoretical NLO QCD predictions. The results of exclusive dijet production were compared to predictions from models which are based on different assumptions about the nature of diffractive exchange. Isolated prompt photons in diffractive photoproduction produced inclusively or together with a jet were studied for the first time.

  10. Optical Telescope Design Study Results

    NASA Astrophysics Data System (ADS)

    Livas, J.; Sankar, S.

    2015-05-01

    We report on the results of a study conducted from Nov 2012-Apr 2013 to develop a telescope design for a space-based gravitational wave detector. The telescope is needed for efficient power delivery but since it is directly in the beam path, the design is driven by the requirements for the overall displacement sensitivity of the gravitational wave observatory. Two requirements in particular, optical pathlength stability and scattered light performance, are beyond the usual specifications for good image quality encountered in traditional telescopic systems. An important element of the study was to tap industrial expertise to develop an optimized design that can be reliably manufactured. Key engineering and design trade-offs and the sometimes surprising results will be presented.

  11. Seeds in space experiment results

    NASA Technical Reports Server (NTRS)

    Alston, Jim A.

    1991-01-01

    Two million seeds of 120 different varieties representing 106 species, 97 genera, and 55 plant families were flown aboard the Long Duration Exposure Facility (LDEF). The seeds were housed on the space exposed experiment developed for students (SEEDS) tray in sealed canister number six and in two small vented canisters. The tray was in the F-2 position. The seeds were germinated and the germination rates and development of the resulting plants compared to the control seed that stayed in Park Seed's seed storage facility. The initial results are presented. There was a better survival rate in the sealed canister in space than in the storage facility at Park Seed. At least some of the seeds in each of the vented canisters survived the exposure to vacuum for almost six years. The number of observed apparent mutations was very low.

  12. First results from SAGE II

    SciTech Connect

    Aburashitov, J.N.; Faizov, E.L.; Gavrin, V.N.; Gusev, A.O.; Kalikhov, A.V.; Knodel, T.V.; Knyshenko, I.I.; Kornoukhov, V.N.; Mirmov, I.N.; Pshukov, A.M.; Shalagin, A.M.; Shikhin, A.A.; Timofeyev, P.V.; Veretenkin, E.P.; Vermul, V.M.; Zatsepin, G.T.; Bowles, T.J.; Nico, J.S.; Teasdale, W.A.; Wark, D.L.; Wilkerson, J.F.; Cleveland, B.T.; Daily, T.; Davis, R. Jr.; Lande, K.; Lee, C.K.; Wildenhain, P.W.; Elliott, S.R.; Cherry, M.L.

    1995-07-10

    The Russian-American Gallium solar neutrino Experiment (SAGE) began the second phase of operation (SAGE II) in September of 1992. Monthly measurements of the integral flux of solar neutrinos have been made with 55 tonnes of gallium. The K-peak results of the first five runs of SAGE II give a capture rate of 76{sup +21}{sub {minus}18}(stat){sup +5}{sub {minus}7}(sys) SNU. Combined with the SAGE I result, the capture rate is 74{sup +13}{sub {minus}12}(stat){sup +5}{sub {minus}7}(sys) SNU. This represents only 56%--60% of the capture rate predicted by different Standard Solar Models. {copyright} {ital 1995} {ital American} {ital Institute} {ital of} {ital Physics}.

  13. Forget about data, deliver results

    NASA Astrophysics Data System (ADS)

    Walter, Roland

    2015-12-01

    High-energy astrophysics space missions have pioneered and demonstrated the power of legacy data sets for generating new discoveries, especially when analysed in ways original researchers could not have anticipated. The only way to ensure that the data of present observatories can be effectively used in the future is to allow users to perform on-the-fly data analysis to produce straightforwardly scientific results for any sky position, time and energy intervals without requiring mission specific software or detailed instrumental knowledge. Providing a straightforward interface to complex data and data analysis makes the data and the process of generating science results available to the public and higher education and promotes the visibility of the investment in science to the society. This is a fundamental step to transmit the values of science and to evolve towards a knowledge society.

  14. Top physics results from CDF

    SciTech Connect

    Gomez, Gervasio; /Cantabria Inst. of Phys.

    2005-05-01

    The top quark is by far the most massive fundamental particle observed so far, and the study of its properties is interesting for several reasons ranging from its possible special role in electroweak symmetry breaking to its sensitivity to physics beyond the Standard Model. They present recent top physics results from CDF based on 160-320 pb{sup -1} of p{bar p} collision data at {radical}s = 1.96 TeV. The t{bar t} cross section and the top mass have been measured in different decay channels and using different methods. they have searched for evidence of single top production, setting upper limits on its production rate. Other results shown in this conference include studies of the polarization of W bosons from top decays, a search for charged Higgs decaying from top, and a search for additional heavy t' quarks.

  15. Airborne laser topographic mapping results

    NASA Technical Reports Server (NTRS)

    Krabill, W. B.; Collins, J. G.; Link, L. E.; Swift, R. N.; Butler, M. L.

    1984-01-01

    The results of terrain mapping experiments utilizing the National Aeronautics and Space Administration (NASA) Airborne Oceanographic Lidar (AOL) over forested areas are presented. The flight tests were conducted as part of a joint NASA/U.S. Army Corps of Engineers (CE) investigation aimed at evaluating the potential of an airborne laser ranging system to provide cross-sectional topographic data on flood plains that are difficult and expensive to survey using conventional techniques. The data described in this paper were obtained in the Wolf River Basin located near Memphis, TN. Results from surveys conducted under winter 'leaves off' and summer 'leaves on' conditions, aspects of day and night operation, and data obtained from decidous and coniferous tree types are compared. Data processing techniques are reviewed. Conclusions relative to accuracy and present limitations of the AOL, and airborne lidar systems in general, to terrain mapping over forested areas are discussed.

  16. Planck 2015 results and inflation

    NASA Astrophysics Data System (ADS)

    Bouchet, François R.

    2015-12-01

    The Planck mission prime objective was a very accurate and complete measurement of the temperature anisotropies of the Cosmic Microwave Background (CMB). Cosmological results from the intensity data of the nominal mission of a duration of 15 months were disclosed on 21 March 2013. Fortunately, the satellite kept acquiring data for at least twice longer, and we announced in February 2015 new results based on all the data acquired, both in temperature and polarization. I provide a short overview of the latest data and findings of most interest for inflation, as a basis for the other contributions to this volume. This overview is entirely based on the published or submitted works of the Planck collaboration. xml:lang="fr"

  17. Surveyor 3 Preliminary Science Results

    NASA Technical Reports Server (NTRS)

    1967-01-01

    Surveyor III soft-landed on the Moon at 00:04 GMT on April 20, 1967. Data obtained have significantly increased our knowledge of the Moon. The Surveyor III spacecraft was similar to Surveyor I; the only major change in scientific instrumentation was the addition of a soil mechanics surface sampler. Surveyor III results at this preliminary evaluation of data give valuable information about the relation between the surface skin of under-dense material responsible for the photometric properties and the deeper layers of material whose properties resemble those of ordinary terrestrial soils. In addition, they provide new insight into the relation between the general lunar surface as seen by Surveyor I and the interior of a large subdued crater. The new results have also contributed to our understanding of the mechanism of downhill transport. Many critical questions cannot, however, be answered until final reduction of experimental data.

  18. Recent results from SND detector

    NASA Astrophysics Data System (ADS)

    Achasov, M. N.; Barnyakov, A. Yu.; Beloborodov, K. I.; Berdyugin, A. V.; Bogdanchikov, A. G.; Botov, A. A.; Dimova, T. V.; Druzhinin, V. P.; Golubev, V. B.; Kardapoltsev, L. V.; Kharlamov, A. G.; Koop, I. A.; Korol, A. A.; Koshuba, S. V.; Kovrizhin, D. P.; Kupich, A. S.; Martin, K. A.; Obrazovsky, A. E.; Pakhtusova, E. V.; Rogozina, E. V.; Serednyakov, S. I.; Shatunov, Yu. M.; Shtol, D. A.; Silagadze, Z. K.; Surin, I. K.; Usov, Yu. V.; Vasiljev, A. V.

    2016-05-01

    Recent results from the SND detector obtained in experiments at the VEPP-2000 e+e- collider are presented. The reactions e+e- → ηπ+π-, e+e- → K+K-, e+e- → π+π-π0, e+e- → ωπ0, e+e- → ωη have been studied in the energy region 1.05-2.00 GeV. The neutron and proton electromagnetic form factors have been measured in the energy range from the threshold up to 2 GeV. The result of the search of the rare process e+e- → η' is also presented.

  19. Measuring the results of faith.

    PubMed

    Hudson, T

    1996-09-20

    Guiding patients to health takes more than technological wizardry, wonder drugs, and pleasantly decorated surroundings. In fact, to an increasing number of institutions, faith is the missing ingredient. Faith in a higher power. Faith in oneself. Faith in the possibilities for recovery. Welcome, then, to the new high-tech, high-touch world, where pastoral care meets managed care. The results may startle you. PMID:8924945

  20. SPQR -- Spectroscopy: Prospects, Questions & Results

    SciTech Connect

    Pennington, Michael R.

    2014-06-01

    Tremendous progress has been made in mapping out the spectrum of hadrons over the past decade with plans to make further advances in the decade ahead. Baryons and mesons, both expected and unexpected, have been found, the results of precision experiments often with polarized beams, polarized targets and sometimes polarization of the final states. All these hadrons generate poles in the complex energy plane that are consequences of strong coupling QCD. They reveal how this works.

  1. Recent DIII-D results

    SciTech Connect

    Petersen, P.I.

    1994-07-01

    This paper summarizes the recent DIII-D experimental results and the development of the relevant hardware systems. The DIII-D program focuses on divertor solutions for next generation tokamaks such as International Thermo-nuclear Experimental Reactor (ITER) and Tokamak Physics Experiment (TPX), and on developing configurations with enhanced confinement and stability properties that will lead to a more compact and economical fusion reactor. The DIII-D program carries out this research in an integrated fashion.

  2. Electroweak results from D0

    SciTech Connect

    Demarteau, M.; D0 Collaboration

    1993-05-01

    Preliminary results from D0 are presented on properties of the W{sup {plus_minus}} and Z{sup 0} electroweak gauge bosons, using final states containing electrons and muons. In particular, preliminary measurements of the W{sup {plus_minus}} and Z{sup 0} production cross sections with decay into final states containing electrons are shown and a status report on the determination of M{sub w}/M{sub z} is given.

  3. Cassini Imaging Results at Titan

    NASA Technical Reports Server (NTRS)

    McEwen, A.; Turtle, E.; Perry J.; Fussner, S.; Porco, C.; West, R.; Johnson, T.; Collins, G.; DelGenio, T.; Barbara, J.

    2005-01-01

    The Cassini Imaging Science Subsystem (ISS) images show striking albedo markings on the surface of Titan. In equatorial regions the albedo patterns have high contrast and exhibit prominent lineaments and linear/angular boundaries suggestive of tectonic influences or fracturing of brittle surficial materials. There are intriguing dark curving lines near the south pole. Here we present several working hypotheses to explain these patterns. We also briefly summarize atmospheric science results.

  4. A-3 scientific results - extragalactic

    NASA Technical Reports Server (NTRS)

    Schwartz, D. A.

    1979-01-01

    The results of the HEAO A-3 experiment are summarized. Specific contributions of the experiment to extragalactic astronomy are emphasized. The discovery of relatively condensed X-ray emission in the cores of those clusters of galaxies which are dominated by a giant elliptical or cD galaxy, the discovery of extended X-ray emitting plasma in groups of galaxies, and the demonstration that BL Lac objects are a class of X-ray sources are among the topics discussed.

  5. Open cherry picker simulation results

    NASA Technical Reports Server (NTRS)

    Nathan, C. A.

    1982-01-01

    The simulation program associated with a key piece of support equipment to be used to service satellites directly from the Shuttle is assessed. The Open Cherry Picker (OCP) is a manned platform mounted at the end of the remote manipulator system (RMS) and is used to enhance extra vehicular activities (EVA). The results of simulations performed on the Grumman Large Amplitude Space Simulator (LASS) and at the JSC Water Immersion Facility are summarized.

  6. Recent QCD results from CDF

    SciTech Connect

    Huston, J. |; CDF Collaboration

    1994-01-01

    CDF has recently concluded a very successful 1992--93 data run in which an integrated luminosity of 21.3 pb {sup {minus}1} was written to tape. The large data sample allows for a greater discovery potential for new phenomena and for better statistical and systematic precision in analysis of conventional physics. This paper summarizes some of the new results from QCD analyses for this run.

  7. B0s Oscillation Results

    SciTech Connect

    Willocq, Stephane

    2002-08-09

    The authors review new studies of the time dependence of B{sub s}{sup 0}-{bar B}{sub s}{sup 0} mixing by the ALEPH, DELPHI and SLD Collaborations, with an emphasis on the different analysis methods used. Combining all available results yields a preliminary lower limit on the oscillation frequency of {Delta}m{sub s} > 14.4 ps{sup -1} at the 95% C.L.

  8. PACOSS program status and results

    NASA Technical Reports Server (NTRS)

    Richards, K. E., Jr.

    1989-01-01

    Future large space systems (LSS), both civilian and military, will have performance objectives which require stringent pointing accuracies, relatively fast retargeting times, short settling times, accurate dynamic shape requirements, or combinations thereof. Many of these structures will be large but lightweight and will exhibit a dense, low-frequency modal spectrum with significant content within the control bandwidth. Although it is possible in principle to achieve structural vibration control with purely active means, experience with complex structures has shown that the realities of plant model inaccuracies and real sensor and actuator dynamics frequently combine to produce disappointing results. It was shown that a combination of passive and active control will result in a simpler system which can be expected to be more reliable and less expensive than a corresponding system utilizing active control exclusively. The goals of the Passive and Active Control of Space Structures (PACOSS) program consist of a thorough investigation of the relative roles of passive active vibration control, and the development of validated means of vibration control. The program approach, representative system article, dynamic test article, and test status and results are outlined.

  9. Heavy Flavour results from Tevatron

    SciTech Connect

    Borissov, G.; /Lancaster U.

    2012-06-01

    The CDF and D0 experiments finalize the analysis of their full statistics collected in the p{bar p} collisions at a center-of-mass energy of {radical}s = 1.96 TeV at the Fermilab Tevatron collider. This paper presents several new results on the properties of hadrons containing heavy b- and c-quarks obtained by both collaborations. These results include the search for the rare decays B{sup 0}, B{sub s}{sup 0} {yields} {mu}{sup +}{mu}{sup -} (CDF), the study of CP asymmetry in B{sub s} {yields} J{psi}{phi} decay (CDF, D0), the measurement of the like-sign dimuon charge asymmetry (D0), the measurement of CP asymmetry in D{sup 0} {yields} K{sup +}K{sup -} and D{sup 0} {yields} {pi}{sup +}{pi}{sup -} decays (CDF), and the new measurement of the B{sub s} {yields} D{sub s}{sup (*)+} D{sub s}{sup (*)-} branching fraction (CDF). Both experiments still expect to produce more results on the properties of heavy flavours.

  10. Phenomena resulting from hypergolic contact

    NASA Astrophysics Data System (ADS)

    Forness, Jordan M.

    Understanding hypergolic ignition is critical for the safe and successful operation of hypergolic engines. The complex coupling of physical and chemical processes during hypergolic ignition complicates analysis of the event. Presently, hypergolic ignition models cannot simulate liquid contact and mixing or liquid-phase chemical reactions, and rely on experimental results for validation. In some cases, chemical kinetics of hypergolic propellants and fluid dynamics of droplet collisions couple to produce unexpected phenomena. This research investigates contact between droplets and pools of liquid hypergolic propellants under various conditions in order to investigate these liquid-phase reactions and categorize the resulting interaction. During this experiment, 142 drop tests were performed to investigate phenomena associated with hypergolic contact of various propellants. A drop of fuel impacted a semi-ellipsoidal pool of oxidizer at varying impact velocities and impact geometries. The temperature, pressure, ambient atmosphere, and propellant quality were all controlled during the experiment, as these factors have been shown to influence hypergolic ignition delay. Three distinct types of impacts were identified: explosions, bounces, and splashes. The impact type was found to depend on the impact Weber number and impact angle. Splashes occurred above a critical Weber number of 250, regardless of impact angle. Explosions occurred for Weber numbers less than 250, and for impact angles less than seven degrees. If the impact angle was greater than seven degrees then the test resulted in a bounce. Literature related to explosions induced by hypergolic contact was reviewed. Explosions were observed to occur inconsistently, a feature that has never been addressed. Literature related to non-reactive splashing, bouncing, and coalescence was reviewed for insight into the explosion phenomenon. I propose that the dependence of impact angle on the transition between explosion and

  11. Electroweak results from the Tevatron

    SciTech Connect

    Demarteau, M.

    1995-10-01

    Results from the CDF and D{O} experiments are presented on properties of the W{plus_minus} and Z{sup 0} gauge bosons using final states containing electrons and muons based on large integrated luminosities. In particular, measurements of the W{plus_minus} and Z{sup 0} production cross sections, the W-charge asymmetry and the CDF measurement of the W-mass are summarized. Gauge boson self interactions axe measured by studying di-gauge boson production and limits on anomalous gauge boson couplings axe discussed.

  12. Recent Results in Solar Neutrinos

    NASA Astrophysics Data System (ADS)

    Saldanha, Richard

    2011-10-01

    Solar neutrinos are an invaluable tool for studying neutrino oscillations in matter as well as probing the nuclear reactions that fuel the Sun. In this talk I will give an overview of solar neutrinos and discuss the latest results in the field. I will highlight the recent precision measurement of the ^7Be solar neutrino interaction rate with the Borexino solar neutrino detector and present the status of the analysis of pep and CNO neutrinos. I will also briefly describe future experiments and their potential to detect low energy solar neutrinos.

  13. Lightcurve Results for Eleven Asteroids

    NASA Astrophysics Data System (ADS)

    Gartrelle, Gordon M.

    2012-04-01

    Differential photometry techniques were used to develop lightcurves, rotation periods and amplitudes for eleven main-belt asteroids: 833 Monica, 962 Aslog, 1020 Arcadia, 1082 Pirola, 1097 Vicia, 1122 Lugduna, 1145 Robelmonte, 1253 Frisia, 1256 Normannia, 1525 Savolinna, and 2324 Janice. Ground-based observations from Badlands Observatory (BLO) in Quinn, SD, as well as the University of North Dakota Observatory (UND) in Grand Forks, ND, provided the data for the project. A search of the asteroid lightcurve database (LCDB) did not reveal any previously reported results for seven of the eleven targets in this study.

  14. Results from IceCube

    NASA Astrophysics Data System (ADS)

    DeYoung, Tyce

    2016-04-01

    Data from the IceCube Neutrino Observatory have revealed the existence of a flux of high energy neutrinos of extraterrestrial origin, which is observed in a number of analyses spanning different energy ranges, fields of view, and neutrino flavors. The current data are consistent with an isotropic, equal-flavor flux described by a simple power law spectrum, but deviations from this simple model cannot yet be constrained with high precision. The existing observations in this area are reviewed, along with recent results on dark matter searches and observations of cosmic rays.

  15. Macular changes resulting from papilloedema.

    PubMed

    Morris, A T; Sanders, M D

    1980-03-01

    Six cases are presented with macular changes in association with papilloedema; 4 suffered permanent visual loss. The present paper emphasises this previously infrequent finding and discusses the haemodynamic and mechanical factors responsible. The macular changes consisted of haemorrhages situated in front, within, or behind the retina, and occasionally the results of neovascular membrane formation produced secondary visual loss. Changes in the pigment epithelium were seen in 3 cases associated with choroidal folds. Macular stars rarely produce visual loss. Recognition of these changes is important in the assessment of the visual loss in papilloedema. PMID:7387954

  16. Results from the HARP Experiment

    SciTech Connect

    Catanesi, M. G.

    2008-02-21

    Hadron production is a key ingredient in many aspects of {nu} physics. Precise prediction of atmospheric {nu} fluxes, characterization of accelerator {nu} beams, quantification of {pi} production and capture for {nu}-factory designs, all of these would profit from hadron production measurements. HARP at the CERN PS was the first hadron production experiment designed on purpose to match all these requirements. It combines a large, full phase space acceptance with low systematic errors and high statistics. HARP was operated in the range from 3 GeV to 15 GeV. We briefly describe here the most recent results.

  17. RSG Deployment Case Testing Results

    SciTech Connect

    Owsley, Stanley L.; Dodson, Michael G.; Hatchell, Brian K.; Seim, Thomas A.; Alexander, David L.; Hawthorne, Woodrow T.

    2005-09-01

    The RSG deployment case design is centered on taking the RSG system and producing a transport case that houses the RSG in a safe and controlled manner for transport. The transport case was driven by two conflicting constraints, first that the case be as light as possible, and second that it meet a stringent list of Military Specified requirements. The design team worked to extract every bit of weight from the design while striving to meet the rigorous Mil-Spec constraints. In the end compromises were made primarily on the specification side to control the overall weight of the transport case. This report outlines the case testing results.

  18. Science verification results from PMAS

    NASA Astrophysics Data System (ADS)

    Roth, M. M.; Becker, T.; Böhm, P.; Kelz, A.

    2004-02-01

    PMAS, the Potsdam Multi-Aperture Spectrophotometer, is a new integral field instrument which was commissioned at the Calar Alto 3.5m Telescope in May 2001. We report on results obtained from a science verification run in October 2001. We present observations of the low-metallicity blue compact dwarf galaxy SBS0335-052, the ultra-luminous X-ray Source X-1 in the Holmberg;II galaxy, the quadruple gravitational lens system Q2237+0305 (the ``Einstein Cross''), the Galactic planetary nebula NGC7027, and extragalactic planetary nebulae in M31. PMAS is now available as a common user instrument at Calar Alto Observatory.

  19. Implicit Media Knowledge Experiments & Results

    NASA Astrophysics Data System (ADS)

    Ly, Muy-Chu; Germaneau, Alexis

    2011-08-01

    Implicit Media Knowledge aims to provide relevant information related to visual media without effort. It is based on the analysis of media usage from several users (e.g. a community). Algorithms based on clustering methods that extract relevant information (e.g. tags, taxonomy trees) related to a media from its usage are detailed. To validate our new approach, we propose to apply our concept and algorithms on a specific media use such as the analysis of how multiple users organize their media files. Significant results of two experiments will be highlighted. Perspectives of our work will be finally presented.

  20. Data bases for LDEF results

    NASA Technical Reports Server (NTRS)

    Bohnhoff-Hlavacek, Gail

    1993-01-01

    The Long Duration Exposure Facility (LDEF) carried 57 experiments and 10,000 specimens for some 200 LDEF experiment investigators. The external surface of LDEF had a large variety of materials exposed to the space environment which were tested preflight, during flight, and post flight. Thermal blankets, optical materials, thermal control paints, aluminum, and composites are among the materials flown. The investigations have produced an abundance of analysis results. One of the responsibilities of the Boeing Support Contract, Materials and Systems Special Investigation Group, is to collate and compile that information into an organized fashion. The databases developed at Boeing to accomplish this task is described.

  1. Results from the HARP Experiment

    NASA Astrophysics Data System (ADS)

    Catanesi, M. G.

    2008-02-01

    Hadron production is a key ingredient in many aspects of ν physics. Precise prediction of atmospheric ν fluxes, characterization of accelerator ν beams, quantification of π production and capture for ν-factory designs, all of these would profit from hadron production measurements. HARP at the CERN PS was the first hadron production experiment designed on purpose to match all these requirements. It combines a large, full phase space acceptance with low systematic errors and high statistics. HARP was operated in the range from 3 GeV to 15 GeV. We briefly describe here the most recent results.

  2. Results from the HARP experiment

    NASA Astrophysics Data System (ADS)

    Catanesi, M. G.

    2007-06-01

    Hadron production is a key ingredient in many aspects of ν physics. Precise prediction of atmospheric ν fluxes, characterization of accelerator ν beams, quantification of π production and capture for ν-factory designs, all of these would profit from hadron production measurements. HARP at the CERN PS was the first hadron production experiment designed on purpose to match all these requirements. It combines a large, full phase space acceptance with low systematic errors and high statistics. HARP was operated in the range from 3 GeV to 15 GeV. We briefly describe here the most recent results.

  3. Long Trace Profiler survey results

    SciTech Connect

    Irick, Steve.

    1999-07-01

    Today the Long Trace Profiler (LTP) is widely accepted as a viable way to measure X-ray mirrors, and at some institutions is the only instrument available for measuring long, high-curvature aspheres. Although some questions of absolute accuracy over the entire LTP measurement range remain unanswered, a comparison of LTPs can still be made to assess measurement variation. Recently a round robin survey of some LTPs within the United States has been made using a single set of mirrors. These mirrors were used to characterize the performance of an LTP over its advertised range of operation. The results of this survey are presented here.

  4. Some Recent Results with CLAS

    SciTech Connect

    Maurik Holtrop

    2010-10-01

    The CLAS is a multipurpose, large acceptance magnetic spectrometer, instrumented with detector systems sensitive to charged and neutral particles. The experimental program at CLAS is aimed at furthering our understanding of hadronic and nuclear physics, through electron and photon scattering experiments, which cover a large range of topics, including meson and baryon spectroscopy, nucleon structure through elastic and deep inelastic scattering, nuclear transparency, nuclear correlations and nuclear structure. This talk will briefly describe the detector and the collaboration that uses it and will highlight some recent results.

  5. Results from the VISA project

    NASA Astrophysics Data System (ADS)

    Kunz, G. J.

    1993-09-01

    The small lidar system has been used to measure the vertical structure of the atmospheric extinction in a dune area bordering The Hague (The Netherlands), at about 2.6 km from the North Sea. The atmospheric optical properties at this location are determined by a mixture of industrial, urban, rural and marine aerosols, which composition depends on the air mass history. The measurements were made unattended, around the clock, five days a week. About 250 extinction profiles were recorded every day. This report reviews the data base obtained and presents some selected results. The lidar system is described briefly. Factors influencing the accuracy of the inversion of lidar signals are discussed.

  6. CP violation results from CDF

    SciTech Connect

    Napier, Austin; /Tufts U.

    2012-01-01

    We present world-leading results on CP-violating asymmetries and branching fractions of several decay modes of B{sup 0}, B{sub s}{sup 0}, and {Lambda}{sub b} hadrons into charmless two-body, and of B{sup {+-}} into charm, final states collected by the CDF detector. We also report a new measurement of CP-violating asymmetries in D*{sup {+-}}-tagged D{sup 0} {yields} h{sup +}h{sup -} (h = K or {pi}) decays, where any enhancement from the Standard Model prediction would be unambiguous evidence for New Physics.

  7. REMS Wind Sensor Preliminary Results

    NASA Astrophysics Data System (ADS)

    De La Torre Juarez, M.; Gomez-Elvira, J.; Navarro, S.; Marin, M.; Torres, J.; Rafkin, S. C.; Newman, C. E.; Pla-García, J.

    2015-12-01

    The REMS instrument is part of the Mars Science Laboratory payload. It is a sensor suite distributed over several parts of the rover. The wind sensor, which is composed of two booms equipped with a set of hot plate anemometers, is installed on the Rover Sensing Mast (RSM). During landing most of the hot plates of one boom were damaged, most likely by the pebbles lifted by the Sky Crane thruster. The loss of one wind boom necessitated a full review of the data processing strategy. Different algorithms have been tested on the readings of the first Mars year, and these results are now archived in the Planetary Data System (PDS), The presentation will include a description of the data processing methods and of the resulting products, including the typical evolution of wind speed and direction session-by-session, hour-by-hour and other kinds of statistics . A review of the wind readings over the first Mars year will also be presented.

  8. [Assessment of bariatric surgery results].

    PubMed

    Barros, Lívia Moreira; Frota, Natasha Marques; Moreira, Rosa Aparecida Nogueira; de Araújo, Thiago Moura; Caetano, Joselany Áfio

    2015-03-01

    The objective was to evaluate the results of bariatric surgery in patients in the late postoperative period using the Bariatric Analysis and Reporting Outcome System (BAROS). This cross-sectional study was conducted from November 2011 to June 2012 at a hospital in the state of Ceará, Brazil. Data were collected from 92 patients using the BAROS protocol, which analyzes weight loss, improved comorbidities, complications, reoperations and Quality of Life (QoL). Data were analysed using the chi-squared test, Fischer's exact test and the Mann-Whitney test. There was a reduction in the Body Mass Index (47.2±6.8 kg/m2 in the pre-operatory and 31.3±5.0 kg/m2 after surgery, p<0.001). The comorbidity with the highest resolution was arterial hypertension (p<0.001), and QV improved in 94.6% of patients. The main complications were hair loss, incisional hernia and cholelithiasis. The surgery provided satisfactory weight loss and improvements in the comorbidities associated to a better QL. Use of the BAROS protocol allows nurses to plan interventions and maintain the good results. PMID:26098798

  9. Double Chooz and recent results

    NASA Astrophysics Data System (ADS)

    Meregaglia, A.; Double Chooz Collaboration

    2016-07-01

    The reactor bar{{ν}}e^{} disappearance experiment Double Chooz, located in France near the power plant of Chooz, has as main goal the measurement of the θ_{{13}}^{} mixing angle. For the first time, in 2011, the experimental results gave an indication for a non-zero value of such an oscillation parameter. The mixing angle was successively measured using only the far detector finding the best fit value of sin2(2 θ_{{13}}^{}) = 0.090+0.033-0.029 . The near detector started data taking in December 2014 and it will allow to reduce the systematic errors so far dominated by the reactor flux uncertainty. In this paper a review of the experiment is presented focusing on the so-called Gadolinium-III results (DOUBLE CHOOZ COLLABORATION (ABE Y. et al.), JHEP, 10 (2014) 086; 02 (2015) 074). Furthermore additional physics measurements are presented such as the capability of Double Chooz to identify the ortho-positronium state on event by event basis.

  10. APS undulator radiation: First results

    SciTech Connect

    Cai, Z.; Dejus, R.J.; Hartog, P.D.

    1995-12-31

    The first undulator radiation has been extracted from the Advanced Photon Source (APS). The results from the characterization of this radiation are very satisfactory. With the undulator set at a gap of 15.8 mm (K=1.61), harmonics as high as the 17th were observed using a crystal spectrometer. The angular distribution of the third-harmonic radiation was measured, and the source was imaged using a zone plate to determine the particle beam emittance. The horizontal beam emittance was found to be 6.9 {plus_minus} 1.0 nm-rad, and the vertical emittance coupling was found to be less than 3%. The absolute spectral flux was measured over a wide range of photon energies, and it agrees remarkably well with the theoretical calculations based on the measured undulator magnetic field profile and the measured beam emittance. These results indicate that both the emittance of the electron beam and the undulator magnetic field quality exceed the original specifications.

  11. AXAF hypervelocity impact test results

    NASA Technical Reports Server (NTRS)

    Frost, Cynthia L.; Rodriguez, Pedro I.

    1997-01-01

    Composite and honeycomb panels are commonly used for spacecraft structural components. The impact test results and analysis of six different composite and honeycomb combinations for use on the advanced X-ray astrophysics facility (AXAF) are reported. The AXAF consists of an X-ray telescope and the associated detecting devices attached to an octagonal spacecraft with an internal propulsion system. The spacecraft's structural panels and optical bench are made of two different graphite fiber reinforced polyimides or composite panels bonded to either side of an aluminum honeycomb. The instrument is required to have at least a 0.92 probability of no failure of any of the critical elements due to meteoroids and debris. In relation to the no-failure probability determination in its low earth orbit environment, hypervelocity impact testing was performed to determine the ballistic limit range and the extent of damage due to impact. The test results for a power and signal cable bundle located behind a panel are presented. Tests planned for a multilayer insulation (MLI) blanket and four types of cable bundles are discussed.

  12. [Drug or plant substances which antagonize venoms or potentiate antivenins].

    PubMed

    Chippaux, J P; Rakotonirina, V S; Rakotonirina, A; Dzikouk, G

    1997-01-01

    Dendroaspis jamesoni (Elapidae) and Echis oceliatus (Viperidae) are responsible for most of severe evenomation in Cameroon. Toxicity of venoms of these two species has been measured using mice according to the method of Spearman & Kàrber. The effect on experimental envenomation of various drugs (atropine, promethazine, neostigmine, hydrocortisone, pentosane sulfuric polyester, heparin, tranexamic acid and aminocaproic acid) and plant extracts (Schumanniophyton magnificum, Bidens pilosa, Securidaca longepedunculata and Garcinia lucida) has been observed associated or not with the antivenom lpser Afrique (SAV). The venom of D. jamesoni contains neurotoxins agonizing and antagonising acetylcholine. The toxicity of the venom did not depend on the route of injection. Atropine, promethazine, neostigmine and hydrocortisone protected animals against a venom dose up to 2 LD50. Moreover, atropine and promethazine potentiated the SAV. Similar results have been obtained with extracts from S. magnificum and B. pilosa. The venom of E. ocellatus induces haemorrhage and necrosis. The toxicity increased by 3-fold when the venom was injected through intravenous or intraperitoneal route, compared to intramuscular route. Pentosane sulfuric polyester and tranexamic acid protected mice against doses up to 3 LD50. Pentosane sulfuric polyester, hydrocortisone, heparin and aminocaproic acid increased the SAV protective titre by 50%. However, tried plant extracts weakly antagonised the venom and did not potentiate the SAV. PMID:9479470

  13. Initial Blackbeard power survey results

    SciTech Connect

    Murphy, T.; Devenport, J.; Holden, D.

    1996-06-01

    The Blackbeard broadband VHF radio receiver is in low-earth orbit aboard the ALEXIS satellite. The receiver has been used to measure the transmitted power in four VHF bands (55.2-75.8, 28.0-94.8, 132.3-152.2, and 107.7-166.0 MHz) over quiet and noisy parts of the earth. The authors present the results of the survey and discuss their implications. They find that there are remote ocean areas over which the observed spectrum is largely free of man-made interference, but that the spectrum over most of the earth is dominated by broadcast VHF signals. The signal characteristics observed over a given area are quite constant when observed at different times of day and at intervals of several weeks to months. It appears that in many cases the bulk of the signal power is coming from a small number of sources.

  14. SPA Meteor Section Results: 2007

    NASA Astrophysics Data System (ADS)

    McBeath, Alastair

    2013-08-01

    Information extracted from analyses carried out by the SPA Meteor Section from 2007 is presented and discussed. Events covered include: the radio Quadrantid maximum on January 4; a bright fireball seen from parts of England and imaged from the Netherlands at 19h56m UT on February 6, for which an approximate trajectory was established; radio results from the Lyrids in late April; the Perseid near-peak activity from August and a note on some daylight Perseid observing from Britain using thermal imagers; the radio α-Aurigid maximum on September 1; the Orionid return, which again provided enhanced activity over several consecutive dates in October for visual and radio observers; the radio Leonids, although the probably main peak found visually on November 19 was not recorded thus due to its timing; the typically protracted Geminid maximum period around December 13-15 as observed visually and by radio; and the Ursid outburst, primarily as detected by radio on December 22.

  15. Results from the Magsat mission

    NASA Technical Reports Server (NTRS)

    Langel, R. A.

    1982-01-01

    The results of analyses of the data gathered by Magsat on the geomagnetic field, crustal magnetic anomalies, fields arising from external current systems, and in investigations of the earth's core, mantle, and core-mantle boundary are presented. A least squares potential function showed that the geomagnetic field was 30,000-50,000 nanoteslas at the Magsat altitude, while fields from external sources were 0-1000 nanoteslas and those from crustal sources 0-50 nanoteslas. Long-wavelength magnetic anomalies were correlated with tectonic features, sometimes reflecting undulations in the Curie isotherm at other times changes in the structure of the lower crust. Detailed anomaly maps from regional data analyses are provided, and possible future spacecraft missions for improving the resolution of contours and strengths of the anomalies are described.

  16. Cryogenic Brush Seal Test Results

    NASA Technical Reports Server (NTRS)

    Proctor, Margaret P.; Walker, James F.

    1996-01-01

    Brush seals are compliant, contact seals that have long-life, low-leakage characteristics desirable for use in rocket engine turbopumps. 50.8-mm (2.0 inch) diameter brush seals with a nominal initial radial interference of 0.127-mm (0.005 inch) were tested in liquid nitrogen at shaft speeds up to 35,000 rpm and differential pressure loads up to 1.21 MPa (175 psi) per brush. The measured leakage rate of a single brush was 2-3 times less than that measured for a 12-tooth, 0.127-mm (0.005 inch) radial clearance labyrinth seal used as a baseline. Stage effects were studied and it was found that two brush seals with a large separation distance leaked less than two brushes tightly packed together. The maximum measured groove depth on the Inconel 718 rotor was 25.4 (mu)m (0.001 inch) after 4.31 hours of shaft rotation. The Haynes-25 bristles wore approximately 25.4-76.2 (mu)m (0.001-0.003 inch) under the same conditions. Three seal runner coatings, chromium carbide, Teflon impregnated chromium, and zirconium oxide, were tested in liquid hydrogen at 35,000 and 65,000 rpm with separate 50.8 mm diameter brush seals made of Haynes-25 bristles and having a nominal initial radial interference of 129 rpm. Two bare Inconel-718 rotors were also tested as a baseline. The test results revealed significant differences between the wear characteristics of the uncoated and coated seal runners. At both speeds the brush seal with the bare Inconel-718 seal runner exhibited significant bristle wear with excessive material transferring to the runner surface. In contrast, the coated seal runners inhibited the transfer and deposit of bristle material. The chromium carbide coating showed only small quantities of bristle material transferring to its surface. The Teflon impregnated chromium coating also inhibited material transfer and provided some lubrication. This coating, however, is self-sacrificing. The Teflon remained present on the low speed runner, but it was completely removed from the

  17. MITG test procedure and results

    SciTech Connect

    Eck, M.B.; Mukunda, M.

    1983-01-01

    Elements and modules for Radioisotope Thermoelectric Generator have been performance tested since the inception of the RTG program. These test articles seldom resembled flight hardware and often lacked adequate diagnostic instrumentation. Because of this, performance problems were not identified in the early stage of program development. The lack of test data in an unexpected area often hampered the development of a problem solution. A procedure for conducting the MITG Test was developed in an effort to obtain data in a systematic, unambiguous manner. This procedure required the development of extensive data acquisition software and test automation. The development of a facility to implement the test procedure, the facility hardware and software requirements, and the results of the MITG testing are the subject of this paper.

  18. Research Results and Information Update

    NASA Astrophysics Data System (ADS)

    2011-01-01

    Research Results Monsoon behavior balanced by glaciers Research Discovers Frequent Mutations of Chromatin Significant Progress in Water Photochemistry Research Structural signature in amorphous alloy formation and plastic deformation The neural basis of Drosophila larval light/darkness preference Important roles of brain-specific carnitine palmitoyltransferase and ceramide metabolism in leptin hypothalamic control of feeding Integrin activation and internalization on soft ECM as a mechanism of induction of stem cell differentiation by ECM elasticity Determination of electron pairing symmetry of iron-based superconductor FeSe Long-Range Topological Order in Metallic Glass Information Update List of Projects Jointly Funded by NSFC and CNRS in 2011 List of Projects Jointly Funded by NSFC and ESRC in 2011 List of Projects Jointly Funded by NSFC and RS in 2011 List of Projects Jointly Funded by NSFC and RSE in 2011 Funding of Major Program Projects in 2010 Funding of Key Program Projects in 2010

  19. Airfreight forecasting methodology and results

    NASA Technical Reports Server (NTRS)

    1978-01-01

    A series of econometric behavioral equations was developed to explain and forecast the evolution of airfreight traffic demand for the total U.S. domestic airfreight system, the total U.S. international airfreight system, and the total scheduled international cargo traffic carried by the top 44 foreign airlines. The basic explanatory variables used in these macromodels were the real gross national products of the countries involved and a measure of relative transportation costs. The results of the econometric analysis reveal that the models explain more than 99 percent of the historical evolution of freight traffic. The long term traffic forecasts generated with these models are based on scenarios of the likely economic outlook in the United States and 31 major foreign countries.

  20. Gravitational microlensing searches and results

    SciTech Connect

    Alcock, C.

    1997-05-08

    Baryonic matter, in the form of Machos (MAssive Compact Halo Objects), might be a significant constituent of the dark matter that dominates the Milky Way. This article describes how surveys for Machos exploit the gravitational microlens magnification of extragalactic stars. The experimental searches for this effect monitor millions of stars, in some cases every night, looking for magnification events. The early results of these surveys indicate that Machos make up a significant fraction of the dark matter in the Milky Way, and that these objects have stellar masses. Truly substellar objects do not contribute much to the total. Additionally, the relatively high event rate towards the Galactic bulge seems to require that the bulge be elongated, and massive.

  1. Preliminary Results of the Analysis

    NASA Technical Reports Server (NTRS)

    Pap, Judit

    1995-01-01

    The preliminary results of the photometry of CaII K spectroheliograms taken at the NationalSolar Observatory at Sacramento peak are presented in this paper. We have digitizedspectroheliograms for 1980 (maximum of SC21), 1985 (minimum of SC21), 1987 (beginning of theascending phase of SC22), 1988 and 1989 (ascending phase and maximum of SC22), and 1992(declining phase of SC22). We have analyzed images for 1992 and separated the plages, the magneticnetwork, internetwork elements and the chromospheric background using histogram method. Wehave derived the intensity and area of these features as well as the full disk intensity (Spatial KIndex). The Spatial K Index has been compared to the spectral Ca K index derived from the lineprofiles and total solar and UV irradiance measured by the UARS and NOAA9 satellites. Thecontribution of plages, the magnetic network and internetwork element to the changes observed intotal solar and UV irradiances are also estimated.

  2. Recent results from telescope array

    NASA Astrophysics Data System (ADS)

    Fukushima, Masaki

    2015-08-01

    The Telescope Array (TA) is an experiment to observe Ultra-High Energy Cosmic Rays (UHECRs). TA's recent results, the energy spectrum and anisotropy based on the 6-year surface array data, and the primary composition obtained from the shower maximum (XMAX) are reported. The spectrum demonstrates a clear dip and cutoff. The shape of the spectrum is well described by the energy loss of extra-galactic protons interacting with the cosmic microwave background (CMB). Above the cutoff, a medium-scale (20∘ radius) flux enhancement was observed near the Ursa-Major. A chance probability of creating this hotspot from the isotropic flux is 4.0 σ. The measured ⟨XMAX⟩ is consistent with the primary being proton or light nuclei for energies 1018.2 eV-1019.2 eV.

  3. Excavating Culture: Summary of Results

    PubMed Central

    Ceballo, Rosario; Chao, Ruth; Hill, Nancy E.; Le, Huynh-Nhu; Murry, Velma McBride; Pinderhughes, Ellen E.

    2013-01-01

    This is a companion paper to the seven articles also published in this special issue of Applied Developmental Science This paper summarizes and discusses the results from common analyses that were conducted on different datasets. The common analyses were designed to disentangle contextual and ethnic influences on parenting. Initial ethnic group differences were found in many of the datasets with multiple ethnic groups. Although certain ethnic group differences were explained by contextual influences, some ethnic group differences remained after contextual influences were controlled. Follow-up analyses with datasets containing cultural variables reveal within group differences in the degree to which ethnic differences in parenting may be accounted for by contextual factors versus culturally-specific processes. Methodological and theoretical implications are discussed and future directions are offered. PMID:24163576

  4. Results from KASCADE-Grande

    NASA Astrophysics Data System (ADS)

    Bertaina, M.; Apel, W. D.; Arteaga-Velázquez, J. C.; Bekk, K.; Blümer, J.; Bozdog, H.; Brancus, I. M.; Buchholz, P.; Cantoni, E.; Chiavassa, A.; Cossavella, F.; Daumiller, K.; de Souza, V.; Di Pierro, F.; Doll, P.; Engel, R.; Engler, J.; Finger, M.; Fuhrmann, D.; Ghia, P. L.; Gils, H. J.; Glasstetter, R.; Grupen, C.; Haungs, A.; Heck, D.; Hörandel, J. R.; Huber, D.; Huege, T.; Isar, P. G.; Kampert, K.-H.; Kang, D.; Klages, H. O.; Link, K.; Łuczak, P.; Ludwig, M.; Mathes, H. J.; Mayer, H. J.; Melissas, M.; Milke, J.; Mitrica, B.; Morello, C.; Navarra, G.; Oehlschläger, J.; Ostapchenko, S.; Over, S.; Palmieri, N.; Petcu, M.; Pierog, T.; Rebel, H.; Roth, M.; Schieler, H.; Schröder, F. G.; Sima, O.; Toma, G.; Trinchero, G. C.; Ulrich, H.; Weindl, A.; Wochele, J.; Wommer, M.; Zabierowski, J.

    2012-11-01

    The KASCADE-Grande experiment, located at Karlsruhe Institute of Technology (Germany) is a multi-component extensive air-shower experiment devoted to the study of cosmic rays and their interactions at primary energies 1014-1018 eV. Main goals of the experiment are the measurement of the all-particle energy spectrum and mass composition in the 1016-1018 eV range by sampling charged (Nch) and muon (Nμ) components of the air shower. The method to derive the energy spectrum and its uncertainties, as well as the implications of the obtained result, is discussed. An overview of the analyses performed by KASCADE-Grande to derive the mass composition of the measured high-energy comic rays is presented as well.

  5. Wake Vortex Algorithm Scoring Results

    NASA Technical Reports Server (NTRS)

    Robins, R. E.; Delisi, D. P.; Hinton, David (Technical Monitor)

    2002-01-01

    This report compares the performance of two models of trailing vortex evolution for which interaction with the ground is not a significant factor. One model uses eddy dissipation rate (EDR) and the other uses the kinetic energy of turbulence fluctuations (TKE) to represent the effect of turbulence. In other respects, the models are nearly identical. The models are evaluated by comparing their predictions of circulation decay, vertical descent, and lateral transport to observations for over four hundred cases from Memphis and Dallas/Fort Worth International Airports. These observations were obtained during deployments in support of NASA's Aircraft Vortex Spacing System (AVOSS). The results of the comparisons show that the EDR model usually performs slightly better than the TKE model.

  6. Monsoon '90 - Preliminary SAR results

    NASA Technical Reports Server (NTRS)

    Dubois, Pascale C.; Van Zyl, Jakob J.; Guerra, Abel G.

    1992-01-01

    Multifrequency polarimetric synthetic aperture radar (SAR) images of the Walnut Gulch watershed near Tombstone, Arizona were acquired on 28 Mar. 1990 and on 1 Aug. 1990. Trihedral corner reflectors were deployed prior to both overflights to allow calibration of the two SAR data sets. During both overflights, gravimetric soil moisture and dielectric constant measurements were made. Detailed vegetation height, density, and water content measurements were made as part of the Monsoon 1990 Experiment. Preliminary results based on analysis of the multitemporal polarimetric SAR data are presented. Only the C-band data (5.7-cm wavelength) radar images show significant difference between Mar. and Aug., with the strongest difference observed in the HV images. Based on the radar data analysis and the in situ measurements, we conclude that these differences are mainly due to changes in the vegetation and not due to the soil moisture changes.

  7. Monsoon 1990: Preliminary SAR results

    NASA Technical Reports Server (NTRS)

    Vanzyl, Jakob J.; Dubois, Pascale; Guerra, Abel

    1991-01-01

    Multifrequency polarimetric synthetic aperture radar (SAR) images of the Walnut Gulch watershed near Tombstone, Arizona were acquired on 28 Mar. 1990 and on 1 Aug. 1990. Trihedral corner reflectors were deployed prior to both overflights to allow calibration of the two SAR data sets. During both overflights, gravimetric soil moisture and dielectric constant measurements were made. Detailed vegetation height, density, and water content measurements were made as part of the Monsoon 1990 Experiment. Preliminary results based on analysis of the multitemporal polarimetric SAR data are presented. Only the C-band data (5.7-cm wavelength) radar images show significant difference between Mar. and Aug., with the strongest difference observed in the HV images. Based on the radar data analysis and the in situ measurements, we conclude that these differences are mainly due to changes in the vegetation and not due to the soil moisture changes.

  8. SMART-1 Payload First Results

    NASA Astrophysics Data System (ADS)

    Foing, B. H.; SMART-1 Science Technology Working Team

    We present first results from SMART-1's science and technology payload, with a total mass of some 19 kg, featuring many innovative instruments and advanced technologies. A miniaturised high-resolution camera (AMIE) for lunar surface imaging, a near-infrared point-spectrometer (SIR) for lunar mineralogy investigation, and a very compact X-ray spectrometer (D-CIXS) with a new type of detector and micro-collimator which will provide fluorescence spectroscopy and imagery of the Moon's surface elemental composition. The payload also includes an experiment (KaTE) aimed at demonstrating deep-space telemetry and telecommand communications in the X and Ka-bands, a radio-science experiment (RSIS), a deep space optical link (Laser-Link Experiment), using the ESA Optical Ground station in Tenerife, and the validation of a system of autonomous navigation (OBAN) based on image processing. SMART-1 lunar science investigations include studies of the chemical composition of the Moon, of geophysical processes (volcanism, tectonics, cratering, erosion, deposition of ices and volatiles) for comparative planetology, and high resolution studies in preparation for future steps of lunar exploration. The mission could address several topics such as the accretional processes that led to the formation of rocky planets, and the origin and evolution of the Earth-Moon system. The SMART-1 observations will be coordinated with Japanese missions Lunar-A and SELENE, to answer open questions about comparative planetology, the origin of the Earth --Moon system, the early evolution of life, the planetary environment and the existence of in-situ resources necessary to support human presence (e.g. water, oxygen). With their science and technology results, these missions can be considered as preparatory missions for future robotic and human exploration of the solar system.

  9. Huygens GCMS Results from Titan

    NASA Technical Reports Server (NTRS)

    Niemann, Hasso B.; Demick, Jaime; Kasprzak, Wayne; Atreya, Sushil; Owen, Tobias

    2007-01-01

    The Huygens Probe executed a successful entry, descent and impact on the Saturnian moon of Titan on January 14, 2005. The Gas Chromatograph Mass Spectrometer (GCMS) instrument conducted isotopic and compositional measurements throughout the two and one half hour descent from 146 km altitude, and on the surface for 69 minutes until loss of signal from the orbiting Cassini spacecraft. The GCMS incorporated a quadrupole mass filter with a secondary electron multiplier detection system. The gas sampling system provided continuous direct atmospheric composition measurements and batch sampling through three gas chromatographic (GC) columns, a chemical scrubber and a hydrocarbon enrichment cell. The GCMS gas inlet was heated to prevent condensation, and to evaporate volatiles from the surface after impact. Data products from the GCMS included altitude profiles of the major atmospheric constituents dinitrogen (N2) and methane (CH4), isotope ratios of 14N/15N, 12C/13C, and D/H, mole fractions of radiogenic argon (40Ar) and primordial argon (36Ar), and upper limits on the mole fractions of neon, krypton and xenon, which were found to be absent. Surface measurements confirmed the presence of ethane (C2H6) and cyanogen (C2N2). Later data products expanded atmospheric profiles to include the surface response of C2N2. C2H6, acetylene (C2H2), and carbon dioxide (CO2). More recent results include the profiles of benzene (C6H6) and molecular hydrogen (H2). The GCMS data are being further analyzed to obtain higher precision results and to identify other trace species ion the atmosphere and evaporating from the surface.

  10. Comparative Soot Diagnostics: Preliminary Results

    NASA Technical Reports Server (NTRS)

    Urban, David L.; Griffin, DeVon W.; Gard, Melissa Y.

    1997-01-01

    detected and suppressed. Prior to CSD, no combustion-generated particulate samples had been collected near the flame zone for well-developed microgravity flames. All of the extant data either came from drop tower tests and therefore only corresponded to the early stages of a fire or were collected far from the flame zone. The fuel sources in the drop tower tests were restricted to laminar gas-jet diffusion flames and very rapidly overheated wire insulation. The gas-jet tests indicated, through thermophoretic sampling, (2) that soot primaries and aggregates (groups of primary particles) in low-gravity may be significantly larger than those in normal gravity (1-g). This raises new scientific questions about soot processes as well as practical issues for particulate size sensitivity and detection alarm threshold levels used in on-orbit smoke detectors. Preliminary tests in the 2.2 second drop tower suggest that particulate generated by overheated wire insulation may be larger in low-g than in 1-g. Transmission Electron Microscope (TEM) grids downstream of the fire region in the Wire Insulation Flammability experiment as well as visual observation of long string-like aggregates, further confirm this suggestion. The combined impact of these limited results and theoretical predictions is that, as opposed to extrapolation from l-g data, direct knowledge of low-g combustion particulate is needed for more confident design of smoke detectors for spacecraft. This paper describes the operation and preliminary results of the CSD, a project conceived and developed at NASA Lewis Research Center. The CSD flight experiment was conducted in the Middeck Glovebox Facility (MGBX) on USMP-3. The project is support by NASA Headquarters Microgravity Science and Applications Division and Code Q. The results presented here are from the microgravity portion of the experiment, including the temporal response of the detectors and average sizes of the primary and aggregate particles captured on the

  11. Geophysical Model Research and Results

    SciTech Connect

    Pasyanos, M; Walter, W; Tkalcic, H; Franz, G; Flanagan, M

    2004-07-07

    Geophysical models constitute an important component of calibration for nuclear explosion monitoring. We will focus on four major topics: (1) a priori geophysical models, (2) surface wave models, (3) receiver function derived profiles, and (4) stochastic geophysical models. The first, a priori models, can be used to predict a host of geophysical measurements, such as body wave travel times, and can be derived from direct regional studies or even by geophysical analogy. Use of these models is particularly important in aseismic regions or regions without seismic stations, where data of direct measurements might not exist. Lawrence Livermore National Laboratory (LLNL) has developed the Western Eurasia and North Africa (WENA) model which has been evaluated using a number of data sets, including travel times, surface waves, receiver functions, and waveform analysis (Pasyanos et al., 2004). We have joined this model with our Yellow Sea - Korean Peninsula (YSKP) model and the Los Alamos National Laboratory (LANL) East Asia model to construct a model for all of Eurasia and North Africa. Secondly, we continue to improve upon our surface wave model by adding more paths. This has allowed us to expand the region to all of Eurasia and into Africa, increase the resolution of our model, and extend results to even shorter periods (7 sec). High-resolution models exist for the Middle East and the YSKP region. The surface wave results can be inverted either alone, or in conjunction with other data, to derive models of the crust and upper mantle structure. We are also using receiver functions, in joint inversions with the surface waves, to produce profiles directly under seismic stations throughout the region. In a collaborative project with Ammon, et al., they have been focusing on stations throughout western Eurasia and North Africa, while we have been focusing on LLNL deployments in the Middle East, including Kuwait, Jordan, and the United Arab Emirates. Finally, we have been

  12. Results of Deposition Scoping Tests

    SciTech Connect

    Hu, M.Z.

    2003-03-04

    The processes of crystallization and solid deposit formation that led to the shutdown of the 2H evaporator operation at the Savannah River Site (SRS) and that could possibly cause similar problems in the future or in other evaporators need to be better understood. Through experimentation, thermodynamic modeling, and correlation of scaling to historical tank farm operations, progress has been made in developing guidelines as to the concentrations of silicon and aluminum that can be processed by evaporators while avoiding unacceptable levels of scale formation. However, because of limitations of the thermodynamic model and an insufficient amount of operational data at slightly supersaturated concentration levels, uncertainty still exists regarding acceptable feed concentrations. The objective of this effort is to provide information that can be used in defining acceptable levels of silicon and aluminum in evaporator feed solutions. Data collected previously showed that particle formation reactions can be rapid at evaporator temperatures for elevated silicon and aluminum concentrations. However, insufficient data exists to estimate the silicon and aluminum concentrations above which solids will form in the time frame of evaporator processing. The work described in this report was designed to determine the induction period for solutions of decreasing aluminum and silicon concentration such that the supersaturation level corresponding to a 4-h induction time for particle nucleation/growth in bulk solution can be estimated. In addition, experiments were conducted to explore the supersaturation levels that can result in deposition of solids on metal surfaces at varying aluminum-to-silicon concentration ratios. Laboratory studies of particle growth in solution were conducted at relatively low supersaturation levels. Dynamic-light-scattering (DLS) studies and deposition tests, similar to those performed in FY 2001, were conducted with solutions at relatively low

  13. Majorana Thermosyphon Prototype Experimental Results

    SciTech Connect

    Fast, James E.; Reid, Douglas J.; Aguayo Navarrete, Estanislao

    2010-12-17

    Objective The Majorana demonstrator will operate at liquid Nitrogen temperatures to ensure optimal spectrometric performance of its High Purity Germanium (HPGe) detector modules. In order to transfer the heat load of the detector module, the Majorana demonstrator requires a cooling system that will maintain a stable liquid nitrogen temperature. This cooling system is required to transport the heat from the detector chamber outside the shield. One approach is to use the two phase liquid-gas equilibrium to ensure constant temperature. This cooling technique is used in a thermosyphon. The thermosyphon can be designed so the vaporization/condensing process transfers heat through the shield while maintaining a stable operating temperature. A prototype of such system has been built at PNNL. This document presents the experimental results of the prototype and evaluates the heat transfer performance of the system. The cool down time, temperature gradient in the thermosyphon, and heat transfer analysis are studied in this document with different heat load applied to the prototype.

  14. Bell Canyon test and results

    SciTech Connect

    Christensen, C. L.; Hunter, T. O.

    1980-01-01

    The purposes of the Borehold Plugging Program are: to identify issues associated with sealing boreholes and shafts; to establish a data base from which to assess the importance of these issues; and to develop sealing criteria, materials, and demonstrative test for the Waste Isolation Pilot Plant (WIPP). The Bell Canyon Test described in this report is one part of that program. Its purpose was to evaluate, in situ, the state of the art in borehole plugs and to identify and resolve problems encountered in evaluating a typical plug installation in anhydrite. The test results are summarized from the work of Peterson and Christensen and divided into two portions: system integrity and wellbore characterization tests prior to plug installation, and a series of tests to evaluate isolation characteristics of the 1.8-m-long plug. Conclusions of the Bell Canyon Test are: brine and fresh-water grouts, with acceptable physical properties in the fluid and hardened states, have been developed; the field data, taken together with laboratory data, suggest that the predominant flow into the test region occurs through the cement plug/borehold interface region, with lesser contributions occurring through the wellbore damage zone, the plug core, and the surrounding undisturbed anhydrite bed; and the 1.8-m-long by 20-cm-diameter grout plug, installed in anhydrite at a depth of 1370 m in the AEC-7 borehole, limits flow from the high pressure Bell Canyon aquifer to 0.6 liters/day.

  15. SPA Meteor Section Results: 2008

    NASA Astrophysics Data System (ADS)

    McBeath, Alastair

    2013-10-01

    A report based on meteor data analyses from 2008 performed by the SPA Meteor Section is given with some discussion. Items detailed comprise: the Quadrantid peak on January 4 which may have had an unusual dip in activity partway through; the Perseid maximum, which seemed to produce two peaks, by far the strongest-recorded of which was around 02h UT on August 13; a meteor outburst on September 9 probably due to the September epsilon-Perseids, for which the radio results suggested activity was present at a stronger level for longer than previous visual and video findings had supposed, perhaps with more than one maximum; another stronger than expected return from the Orionids during October, part of the sequence of unusual events begun in 2006; a fresh Taurid ``swarm'' return in late October to early November, which probably produced somewhat higher activity than normal, if without the increased bright-meteor component observed at some previous returns; strong Leonid activity later in November, from the radio reports, possibly with two peaks; a Geminid maximum in December which showed some curious discrepancies between the limited visual and radio observations; and the Ursids, which may have provided another moderately-enhanced return, with up to four potential peaks recorded by radio observations in the first twelve hours UT of December 22.

  16. ALOHA Cabled Observatory: Early Results

    NASA Astrophysics Data System (ADS)

    Howe, B. M.; Lukas, R.; Duennebier, F. K.

    2011-12-01

    The ALOHA Cabled Observatory (ACO) was installed 6 June 2011, extending power, network communications and timing to a seafloor node and instruments at 4726 m water depth 100 km north of Oahu. The system was installed using ROV Jason operated from the R/V Kilo Moana. Station ALOHA is the field site of the Hawaii Ocean Time-series (HOT) program that has investigated temporal dynamics in biology, physics, and chemistry since 1988. HOT conducts near monthly ship-based sampling and makes continuous observations from moored instruments to document and study climate and ecosystem variability over semi-diurnal to decadal time scales. The cabled observatory system will provide the infrastructure for continuous, interactive ocean sampling enabling new measurements as well as a new mode of ocean observing that integrates ship and cabled observations. The ACO is a prototypical example of a deep observatory system that uses a retired first-generation fiber-optic telecommunications cable. Sensors provide live video, sound from local and distant sources, and measure currents, pressure, temperature, and salinity. Preliminary results will be presented and discussed.

  17. Overview of recent HERMES results

    NASA Astrophysics Data System (ADS)

    Marukyan, Hrachya

    2016-02-01

    An overview of more recent and important results from the HERMES experiment are presented in this paper. HERMES collected a wealth of data using the 27.6 GeV polarized HERA lepton beam and various polarized and unpolarized gaseous targets. This unique data set opens the door to the measurements of observables sensitive to the multidimensional structure of the nucleon. Among them are semi-inclusive deep-inelastic scattering measurements of azimuthal modulations sensitive to the transverse momentum distributions, such as the leading- twist Sivers and Collins distributions and distributions sensitive to the convolutions of the twist-2 and twist-3 functions. They all provide an information on the three-momentum-dependent quark distributions. Knowledge on the quark distribution as a function of longitudinal momentum and transverse position in impact-parameter space can be accessed, e.g., through exclusive ω—meson leptoproduction, particularly through the measurement of spin density matrix elements and the measurement of azimuthal modulations on transversely polarized proton target. The measurement of Bose-Einstein correlations of hadron pairs in quasi-real leptoproduction are also presented. The transverse polarization of Λ hyperons measured again in quasi-real leptoproduction regime are presented as well. Finally, the new analysis for the search on pentaquark at HERMES are mentioned.

  18. EUPORIAS: plans and preliminary results

    NASA Astrophysics Data System (ADS)

    Buontempo, C.

    2013-12-01

    Recent advances in our understanding and ability to forecast climate variability have meant that skilful predictions are beginning to be routinely made on seasonal to decadal (s2d) timescales. Such forecasts have the potential to be of great value to a wide range of decision-making, where outcomes are strongly influenced by variations in the climate. In 2012 the European Commission funded EUPORIAS, a four year long project to develop prototype end-to-end climate impact prediction services operating on a seasonal to decadal timescale, and assess their value in informing decision-making. EUPORIAS commenced on 1 November 2012, coordinated by the UK Met Office leading a consortium of 24 organisations representing world-class European climate research and climate service centres, expertise in impacts assessments and seasonal predictions, two United Nations agencies, specialists in new media, and commercial companies in climate-vulnerable sectors such as energy, water and tourism. The poster describes the setup of the project, its main outcome and some of the very preliminary results.

  19. Results of NSTX Heating Experiments

    SciTech Connect

    D. Mueller; M. Ono; M.G. Bell; R.E. Bell; M. Bitter; C. Bourdelle; D.S. Darrow; P.C. Efthimion; E.D. Fredrickson; D.A Gates; R.J. Goldston; L.R. Grisham; R.J. Hawryluk; K.W. Hill; J.C. Hosea; S.C. Jardin; H. Ji; S.M. Kaye; R. Kaita; H.W. Kugel; D.W. Johnson; B.P. LeBlanc; R. Majeski; E. Mazzucato; S.S. Medley; J.E. Menard; H.K. Park; S.F. Paul; C.K. Phillips; M.H. Redi; A.L. Rosenberg; C.H. Skinner; V.A. Soukhanovskii; B. Stratton; E.J Synakowski; G. Taylor; J.R. Wilson; S.J. Zweben; Y-K.M. Peng; R. Barry; T. Bigelow; C.E. Bush; M. Carter; R. Maingi; M. Menon; P.M. Ryan; D.W. Swain; J. Wilgen; 37 additional authors

    2002-06-18

    The National Spherical Torus Experiment (NSTX) at Princeton is designed to assess the potential of the low-aspect-ratio spherical torus concept for magnetic plasma confinement. The plasma has been heated by up to 5 MW of neutral beam injection, NBI, at an injection energy of 90 keV and up to 6 MW of high harmonic fast wave, HHFW, at 30 MHz. NSTX has achieved beta T of 32%. A variety of MHD phenomena have been observed to limit eta. NSTX has now begun addressing E scaling, eta limits and current drive issues. During the NBI heating experiments, a broad Ti profile with Ti up to 2 keV, Ti > Te and a large toroidal rotation. Transport analysis suggests that the impurity ions have diffusivities approaching neoclassical. For L-Mode plasmas, E is up to two times the ITER-89P L-Mode scaling and exceeds the ITER-98pby2 H-Mode scaling in some cases. Transitions to H-Mode have been observed which result in an approximate doubling of tE. after the transition in some conditions. During HH FW heating, Te > Ti and Te up to 3.5 keV were observed. Current drive has been studied using coaxial helicity injection (CHI), which has produced 390 kA of toroidal current and HHFW, which has produced H-modes with significant bootstrap current fraction at low Ip, high q and high{sub etap}.

  20. Cosmic radioactivity and INTEGRAL results

    SciTech Connect

    Diehl, Roland

    2014-05-02

    Gamma-ray lines from radioactive decay of unstable isotopes co-produced by nucleosynthesis in massive stars and supernova have been measured since more than thirty years. Over the past ten years, INTEGRAL complemented the first sky survey made by COMPTEL. The {sup 26}A1 isotope with 1 My decay time had been first direct proof of currently-ongoing nucleosynthesis in our Galaxy. This has now become a tool to study the ∼My history of specific source regions, such as massive-star groups and associations in nearby regions which can be discriminated from the galactic-plane background, and the inner Galaxy, where Doppler shifted lines add to the astronomical information about bar and spiral structure. Recent findings suggest that superbubbles show a remarkable asymmetry, on average, in the spiral arms of our galaxy. {sup 60}Fe is co-produced by the sources of {sup 26}A1, and the isotopic ratio from their nucleosynthesis encodes stellar-structure information. Annihilation gamma-rays from positrons in interstellar space show a puzzling bright and extended source region central to our Galaxy, but also may be partly related to nucleosynthesis. {sup 56}Ni and {sup 44}Ti isotope gamma-rays have been used to constrain supernova explosion mechanisms. Here we report latest results using the accumulated multi-year database of INTEGRAL observations, and discuss their astrophysical interpretations, connecting to other traces of cosmic radioactivity and to other cosmic messengers.

  1. Immunological results in myocardial diseases.

    PubMed Central

    Bolte, H. D.; Schultheiss, P.

    1978-01-01

    Immunological studies have shown new diagnostically important changes in alcoholic and viral myocarditis, as well as in congestive cardiomyopathy. Increased heart size correlated with the degree of congestive heart failure, as well as with negative immunofluorescence and an increased IgA concentration in the serum. These findings may serve as a diagnostic aid in patients with myocardial disease due to alcohol abuse. Viral heart disease is characterized by a variety of symptoms and nuclear antibodies (IgM) can be of help in the differential diagnosis. Heart muscle tissue of patients with congestive cardiomyopathy preferentially binds IgG and IgA. In addition to the other changes these findings are of diagnostic importance. It seems likely that results similar to those obtained for humoral antibodies in congestive cardiomyopathy will apply in the correlation of the haemodynamic status of the patients. The pathophysiological implication of these findings is not clear at present, but the evolution of congestive cardiomyopathy appears to be associated with binding of immunoglobulin to the myocardium, as well as with humoral antiheart antibodies. PMID:704517

  2. First Results From EUNIS 2005

    NASA Astrophysics Data System (ADS)

    Rabin, D. M.; Thomas, R. J.; Davila, J. M.; Brosius, J. W.; Swartz, M.; Jordan, S. D.

    2005-12-01

    The Extreme Ultraviolet Normal-Incidence Spectrograph (EUNIS) is a sounding rocket experiment to investigate the energetics of the solar corona and hotter transition region through high-resolution imaging spectroscopy with a rapid (2 second) cadence. Pre-flight characterization of throughput has demonstrated that EUNIS is the most sensitive solar EUV spectrograph in existence, having over 100 times the throughput of its predecessor, the Solar Extreme ultraviolet Research Telescope and Spectrograph (SERTS). We report initial results from the first flight in November 2005 from White Sands Missile Range. The main scientific goal of the first EUNIS flight is to extend the investigation of transient phenomena, such as nanoflares and blinkers, to shorter timescales than has been possible with previous EUV spectrographs. The two independent optical systems of EUNIS record spatially co-aligned spectra over two passbands (170--205 Å and 300--370 Å) simultaneously with spectral resolution of 60 mÅ or 120 mÅ, respectively. The longwave passband includes He II 304 Å and strong lines from Fe XI--XVI. The shortwave passband has a sequence of very strong Fe IX--XIII lines. Together, the EUNIS telescopes furnish a wide range of temperature and density diagnostics and enable underflight calibration of instrumental passbands on the SOHO, TRACE, Solar-B, and STEREO missions.

  3. Results from the NEXT prototypes

    NASA Astrophysics Data System (ADS)

    Oliveira, C. A. B.; NEXT Collaboration

    2013-10-01

    NEXT-100 is an electroluminescent high pressure Time Projection Chamber currently under construction. It will search for the neutrino-less double beta decay in 136Xe at the Canfranc Underground Laboratory. NEXT-100 aims to achieve nearly intrinsic energy resolution and to highly suppress background events by taking advantage of the unique properties of xenon in the gaseous phase as the detection medium. In order to prove the principle of operation and to study which are the best operational conditions, two prototypes were constructed: NEXT-DEMO and NEXT-DBDM. In this paper we present the latest results from both prototypes. We report the improvement in terms of light collection (~ 3×) achieved by coating the walls of NEXT-DEMO with tetraphenyl butadiene (TPB), the outstanding energy resolution of 1 % (Full Width Half Maximum) from NEXT-DBDM as well as the tracking capabilities of this prototype (2.1 mm RMS error for point-like depositions) achieved by using a square array of 8 × 8 SiPMs.

  4. Visible Nulling Coronagraph Testbed Results

    NASA Technical Reports Server (NTRS)

    Lyon, Richard G.; Clampin, Mark; Melnick, Gary; Tolls, Volker; Woodruff, Robert; Vasudevan, Gopal; Rizzo, Maxime; Thompson, Patrick

    2009-01-01

    The Extrasolar Planetary Imaging Coronagraph (EPIC) is a NASA Astrophysics Strategic Mission Concept study and a proposed NASA Discovery mission to image and characterize extrasolar giant planets in orbits with semi-major axes between 2 and 10 AU. EPIC would provide insights into the physical nature of a variety of planets in other solar systems complimenting radial velocity (RV) and astrometric planet searches. It will detect and characterize the atmospheres of planets identified by radial velocity surveys, determine orbital inclinations and masses, characterize the atmospheres around A and F stars, observed the inner spatial structure and colors of inner Spitzer selected debris disks. EPIC would be launched to heliocentric Earth trailing drift-away orbit, with a 5-year mission lifetime. The starlight suppression approach consists of a visible nulling coronagraph (VNC) that enables starlight suppression in broadband light from 480-960 nm. To demonstrate the VNC approach and advance it's technology readiness we have developed a laboratory VNC and have demonstrated white light nulling. We will discuss our ongoing VNC work and show the latest results from the VNC testbed.

  5. SAA drift:experimental results

    NASA Astrophysics Data System (ADS)

    Grigoryan, O. R.; Kudela, K.; Romashova, V. V.; Drozdov, A. Yu.

    According to the paleomagnetic analysis there are variations of Earth's magnetic field connected with magnetic momentum changing. Besides these variations affects on the trapped belt South Atlantic Anomaly (SAA) location. Indeed different observations including Space Shuttle short-time flights approved the existence SAA westward drift with speed 0.1-1.0 (deg/year) and northward drift with speed approximately 0.1 (deg/year). In this work we present the analysis of experimental results obtained in SINP MSU in 1972-2003 from different satellites. There were analyzed the fluxes of protons with energy > 50 MeV, gamma quanta with energy > 500 keV and neutrons with energy 0.1-1.0 MeV in SAA area and their maxima location. The data about fluxes were obtained onboard the orbital stations ``Salut-6'' (1979), MIR (1991, 1998) and ISS (2003) by the identical experimental equipment. The comparison of the data obtained during these two decades of investigations confirms the fact of the SAA westward drift. Moreover the same analysis of maximum flux location of electrons with hundreds keV energy (satellites ``Kosmos-484'' (1972), ``Interkosmos-17'' (1977) and ``Activny'' (``Interkosmos-24'', 1991)) confirmed not only the SAA westward drift but northward drift also.

  6. Collaborative Behavioral Teratology Study: results.

    PubMed

    Buelke-Sam, J; Kimmel, C A; Adams, J; Nelson, C J; Vorhees, C V; Wright, D C; St Omer, V; Korol, B A; Butcher, R E; Geyer, M A

    1985-01-01

    Behavioral measures used in the Collaborative Behavioral Teratology Study (CBTS) were negative geotaxis (PNDs 7-10), olfactory discrimination (PNDs 9-11), auditory startle habituation (PNDs 18-19 and 57-58), 1-hr activity (PNDs 21, 60, 100 and 120), 23-hr activity (PND 100), activity following a pharmacological challenge (PND 120), and an operant, discrete trial visual discrimination task. Maternal and offspring body weights and the appearance of certain physical landmarks of development were also monitored. The design of the CBTS allowed evaluation of the reproducibility and detection sensitivity of these behavioral test methods, as well as the impact of early testing experience on later behavioral assessment, offspring sex differences in response levels and variability, and the contribution of litter-to-litter and animal-to-animal variation to behavioral measures in a standardized test protocol. The results obtained in this test system are discussed in relation to each of these factors and to the degree of overt toxicity obtained using prenatal treatment with 0, 0.5 or 2.0 mg/kg d-amphetamine sulfate, SC, on gestation days 12-15 (Study 1) or methylmercuric chloride, 0, 2.0 or 6.0 mg/kg by gavage, on gestation days 6-9 (Study 2). PMID:3835454

  7. Results of PLACES data analysis

    NASA Astrophysics Data System (ADS)

    Prettie, C. W.

    1982-09-01

    The results of analyses performed to support PLACES data reduction and data interpretation are presented. Beacon receiver measurements of the scattering of a 100 MHz pseudo-noise beacon signal BPSK modulated at a 10 MHz rate were made during an occulatation by the structured IRIS ion cloud. The scattering produced features in the received St. George Island signal that are shown to be in good quantitative agreement with propagation effect predictions produced from an optically derived model of the ion cloud extent. The features in the received data are also in qualitative agreement with the optical features in a coincident St. George Island photograph. Neutral wind shear rate is determined in the optical analyses to be directed with a 351 deg azimuth with a 1.5 meter per second per kilometer of altitude magnitude. Aircraft propagation measurements of the JAN ion cloud reveal a steady decay of the TEC until the cloud effects vanish at roughly 200 minutes after release. The following mechanism is proposed to explain late time barium cloud decay: Barium ions are removed from the ion cloud as current carriers and are replaced by molecular air ions which quickly recombine. The mechanism is found to be highly efficient. The kHz frequency spurs in the NRL density probe data from JAN are briefly investigated. The spur frequency is found to have no clear-cut dependence on local density, is not confined to the ion cloud region, and at times two spurs are visible in the data.

  8. First results from Spacelab 2

    NASA Technical Reports Server (NTRS)

    Urban, E. W.

    1986-01-01

    Preliminary results of physical experiments carried out during the Spacelab 2 Shuttle mission are summarized. Attention is given to experiments in the fields of plasma dynamics; solar physics; high-energy astrophysics; and astronomy. Plasma experiments included an ejectable plasma diagnosics package and measurements of the passive charging of the Shuttle vehicle in the surrounding space plasma. The solar physics instrument package consisted of a solar spectral irradiance monitor; a solar optical universal polarimeter (SOUP); and a solar helium abundance high-resolution telescope and spectrograph (HRTS). Astronomical observations were performed using a scanning infrared telescope (IRT) which consisted of a highly baffled herschelian telescope and 10 detectors covering wavelengths from 2 to 120 microns. Cosmic-ray nuclei were detected and analyzed using gas Cerenkov counters and a transition radiation detector. Addition experiments included a thin film fluid dynamics payload and analysis of blood samples taken from the mission specialists. Complete data records from the experiments have now been distributed for an analysis period which will take at least a year. A table listing the Spacelab 2 experiments and their principal investigators is provided.

  9. Mobile evaporator corrosion test results

    SciTech Connect

    Rozeveld, A.; Chamberlain, D.B.

    1997-05-01

    Laboratory corrosion tests were conducted on eight candidates to select a durable and cost-effective alloy for use in mobile evaporators to process radioactive waste solutions. Based on an extensive literature survey of corrosion data, three stainless steel alloys (304L, 316L, AL-6XN), four nickel-based alloys (825, 625, 690, G-30), and titanium were selected for testing. The corrosion tests included vapor phase, liquid junction (interface), liquid immersion, and crevice corrosion tests on plain and welded samples of candidate materials. Tests were conducted at 80{degrees}C for 45 days in two different test solutions: a nitric acid solution. to simulate evaporator conditions during the processing of the cesium ion-exchange eluant and a highly alkaline sodium hydroxide solution to simulate the composition of Tank 241-AW-101 during evaporation. All of the alloys exhibited excellent corrosion resistance in the alkaline test solution. Corrosion rates were very low and localized corrosion was not observed. Results from the nitric acid tests showed that only 316L stainless steel did not meet our performance criteria. The 316L welded interface and crevice specimens had rates of 22.2 mpy and 21.8 mpy, respectively, which exceeds the maximum corrosion rate of 20 mpy. The other welded samples had about the same corrosion resistance as the plain samples. None of the welded samples showed preferential weld or heat-affected zone (HAZ) attack. Vapor corrosion was negligible for all alloys. All of the alloys except 316L exhibited either {open_quotes}satisfactory{close_quotes} (2-20 mpy) or {open_quotes}excellent{close_quotes} (<2 mpy) corrosion resistance as defined by National Association of Corrosion Engineers. However, many of the alloys experienced intergranular corrosion in the nitric acid test solution, which could indicate a susceptibility to stress corrosion cracking (SCC) in this environment.

  10. Pouchitis: result of microbial imbalance?

    PubMed Central

    Ruseler-van Embden, J G; Schouten, W R; van Lieshout, L M

    1994-01-01

    To elucidate the role of microbiological factors in pouchitis, this study investigated the composition of ileal reservoir microflora, the mucus degrading capacity of bacterial enzymes as well as the pH and the proteolytic activity of pouch effluent. Stool samples were collected from five patients with pouchitis and nine patients without pouchitis. The flora of patients with pouchitis had an increased number of aerobes, a decreased ratio anaerobes to aerobes, less bifidobacteria and anaerobic lactobacilli, more Clostridium perfringens, and several species that were not found in control patients (for example, fungi). Furthermore the pH was significantly higher in patients with pouchitis (median value 6.5) than in control patients (5.4). To find out if the pH might influence the breakdown of intestinal mucus glycoproteins, the activity of glycosidases and proteases, and the degradation of hog gastric mucin by the pouch flora was tested at pH 5.2-7.6. Some glycosidases were inhibited, others were stimulated by a low pH, however, in each sample the proteolytic activity was inhibited for 75% at pH 5.2 compared with pH 6.8 and 7.6. Degradation of hog gastric mucin by the pouch flora was an active process at pH 7.2: within two to four hours of incubation more than half of the mucin was degraded. At pH 5.2 it took twice as long. It is concluded that pouchitis possibly results from instability of the flora in the pouch, which causes homeostasis to disappear (dysbiosis), and the protection of the pouch epithelium by the mucus layer becomes affected by increased activity of bacterial and host derived enzymes. PMID:8200561