Science.gov

Sample records for persons conclusions tf

  1. Conclusions

    NASA Astrophysics Data System (ADS)

    Ahonen, Pasi; Alahuhta, Petteri; Daskala, Barbara; Delaitre, Sabine; Hert, Paul De; Lindner, Ralf; Maghiros, Ioannis; Moscibroda, Anna; Schreurs, Wim; Verlinden, Michiel

    Some say that an increase in security does not necessarily mean a further encroachment on privacy - indeed, security is necessary to protect personal data and our privacy. Networks must be secure, our personal devices, reliable, dependable and trustworthy. But security is a multifaceted term, with many dimensions. We are of the view that an increase in security most likely will encroach upon our privacy in an ambient intelligence world. Surveillance cameras will continue to proliferate. We assume that, whatever the law is, whatever privacy protections government and business say they honour, our telecommunications, e-mails and Internet usage will be monitored to an increasing degree. The same will be true of our interfaces with the world of ambient intelligence.

  2. Personality-informed interventions for healthy aging: conclusions from a National Institute on Aging work group.

    PubMed

    Chapman, Benjamin P; Hampson, Sarah; Clarkin, John

    2014-05-01

    We describe 2 frameworks in which personality dimensions relevant to health, such as Conscientiousness, can be used to inform interventions designed to promote health aging. First, contemporary data and theory do not suggest that personality is "immutable," but instead focus on questions of who changes, in what way, why, when, and how. In fact, the notion that personality could be changed was part and parcel of many schools of psychotherapy, which suggested that long-term and meaningful change in symptoms could not be achieved without change in relevant aspects of personality. We review intervention research documenting change in personality. On the basis of an integrative view of personality as a complex system, we describe a bottom-up model of change in which interventions to change basic personality processes eventuate in changes at the trait level. A 2nd framework leverages the descriptive and predictive power of personality to tailor individual risk prediction and treatment, as well as refine public health programs, to the relevant dispositional characteristics of the target population. These methods dovetail with, and add a systematic and rigorous psychosocial dimension to, the personalized medicine and patient-centeredness movements in medicine. In addition to improving health through earlier intervention and increased fit between treatments and persons, cost-effectiveness improvements can be realized by more accurate resource allocation. Numerous examples from the personality, health, and aging literature on Conscientiousness and other traits are provided throughout, and we conclude with a series of recommendations for research in these emerging areas. PMID:23978300

  3. Personality-Informed Interventions for Healthy Aging: Conclusions From a National Institute on Aging Workgroup

    PubMed Central

    Chapman, Benjamin P.; Hampson, Sarah; Clarkin, John

    2013-01-01

    We describe two frameworks in which personality dimensions relevant to health, such as Conscientiousness, can be used to inform interventions designed to promote health aging. First, contemporary data and theory do not suggest that personality is “immutable”, but instead focus on questions of who changes, in what way, why, when, and how. In fact, the notion that personality could be changed was part and parcel of many schools of psychotherapy, which suggested that long term and meaningful change in symptoms could not be achieved without change in relevant aspects of personality. We review intervention research documenting change in personality. Based on an integrative view of personality as a complex system, we describe a “bottom-up” model of change in which interventions to change basic personality processes eventuate in changes at the trait level. A second framework leverages the descriptive and predictive power of personality to tailor individual risk prediction and treatment, as well as refine public health programs, to the relevant dispositional characteristics of the target population. These methods dovetail with and add a systematic and rigorous psychosocial dimension to the personalized medicine and patient-centeredness movements in medicine. In addition to improving health through earlier intervention and increased fit between treatments and persons, cost-effectiveness improvements can be realized by more accurate resource allocation. Numerous examples from the personality, health, and aging literature on Conscientiousness and other traits are provided throughout, and we conclude with a series of recommendations for research in these emerging areas. PMID:23978300

  4. Personality-Informed Interventions for Healthy Aging: Conclusions from a National Institute on Aging Work Group

    ERIC Educational Resources Information Center

    Chapman, Benjamin P.; Hampson, Sarah; Clarkin, John

    2014-01-01

    We describe 2 frameworks in which personality dimensions relevant to health, such as Conscientiousness, can be used to inform interventions designed to promote health aging. First, contemporary data and theory do not suggest that personality is "immutable," but instead focus on questions of who changes, in what way, why, when, and how.…

  5. Assessment on TF ripple

    NASA Astrophysics Data System (ADS)

    Shinohara, Kouji

    2008-11-01

    The TF ripple can reduce fast ion confinement and reduce plasma performance. Additionally, recent experiment results from JT-60U and JET imply that ripple can affect bulk plasma confinement. Here, the characteristics of TF ripple and its effect on fast ion confinement is reported. The TF ripple amplitude in ITER is ˜1.2% in case of TF coil alone at the separatrix. This ripple will be compensated by ferritic inserts (FIs), placed between the vacuum vessel shells. In the current design, the ripple amplitude is 0.4% at the separatrix at full field. It should be noted that, in this case, the ripple is overcompensated at half field and that the ripple amplitude is -0.4%. A test blanket module (TBM), some of whose components are ferromagnetic, is another source of TF ripple. TBMs will be installed at three mid-plane ports. The TF ripple induced by TBMs is localized in the poloidal direction as well as in the toroidal direction. The ripple is ˜1% at the mid-plane. Fast ion confinement was evaluated. The fast ion loss was small <2.5% in the Scenario 2 and 4. However, at half field, the effectiveness of FI is reduced and the TBM enhances the loss; the loss is larger than half of that in case of TFC alone.

  6. Sweet Conclusion

    ERIC Educational Resources Information Center

    Shirley, Britt M.; Wooldridge, Barbara Ross; Camp, Kerri M.

    2012-01-01

    Jen Harrington is the owner and pastry chef of Sweet Conclusion, a bakery in Tampa, Florida. Most of Harrington's business comes from baking wedding cakes, but she has been attempting to attract customers to her retail bakery, where she sells cupcakes, pies, ice cream, and coffee. Nearly four years she opened Sweet Conclusion, the retail part of…

  7. FLOWTRAN-TF code benchmarking

    SciTech Connect

    Flach, G.P.

    1990-12-01

    FLOWTRAN-TF is a two-component (air-water), two-phase thermal-hydraulics code designed for performing accident analyses of SRS reactor fuel assemblies during the Emergency Cooling System (ECS) phase of a Double Ended Guillotine Break (DEGB) Loss Of Coolant Accident (LOCA). A description of the code is given by Flach et al. (1990). This report provides benchmarking results for the version of FLOWTRAN-TF used to compute the Recommended K-Reactor Restart ECS Power Limit (Smith et al., 1990a; 1990b). Individual constitutive relations are benchmarked in Sections 2 through 5 while in Sections 6 and 7 integral code benchmarking results are presented. An overall assessment of FLOWTRAN-TF for its intended use in computing the ECS power limit completes the document.

  8. FLOWTRAN-TF code description

    SciTech Connect

    Flach, G.P.

    1991-09-01

    FLOWTRAN-TF is a two-component (air-water), two-phase thermal-hydraulics code designed for performing accident analyses of SRS reactor fuel assemblies during the Emergency Cooling System (ECS) phase of a Double Ended Guillotine Break (DEGB) Loss of Coolant Accident (LOCA). This report provides a brief description of the physical models in the version of FLOWTRAN-TF used to compute the Recommended K-Reactor Restart ECS Power Limit. This document is viewed as an interim report and should ultimately be superseded by a comprehensive user/programmer manual. In general, only high level discussions of governing equations and constitutive laws are presented. Numerical implementation of these models, code architecture and user information are not generally covered. A companion document describing code benchmarking is available.

  9. FLOWTRAN-TF code description

    SciTech Connect

    Flach, G.P.

    1990-12-01

    FLOWTRAN-TF is a two-component (air-water), two-phase thermal-hydraulics code designed for performing accident analyses of SRS reactor fuel assemblies during the Emergency Cooling System (ECS) phase of a Double Ended Guillotine Break (DEGB) Loss of Coolant Accident (LOCA). This report provides a brief description of the physical models in the version of FLOWTRAN-TF used to compute the Recommended K-Reactor Restart ECS Power Limit. This document is viewed as an interim report and should ultimately be superseded by a comprehensive user/programmer manual. In general, only high level discussions of governing equations and constitutive laws are presented. Numerical implementation of these models, code architecture and user information are not generally covered. A companion document describing code benchmarking is available.

  10. FLOWTRAN-TF software design

    SciTech Connect

    Aleman, S.E.; Flach, G.P.; Hamm, L.L.; Lee, S.Y.; Smith, F.G. III.

    1993-02-01

    FLOWTRAN-TF was created to analyze an individual Mk22 fuel assembly during a large break Loss Of Coolant Accident (LOCA) scenario involving the Savannah River Site K-reactor after the initial few seconds of the transient. During the initial few seconds reactor cooling is limited by the static or Ledinegg flow instability phenomenon. The predecessor FLOWTRAN code was developed to analyze this portion of a LOCA. In the several seconds following the break, a significant fraction of the reactor coolant inventory leaks out the break, Emergency Cooling System (ECS) flow is initiated, and air enters the primary coolant circulation loops. Reactor fuel assemblies are cooled by a low flowrate air-water downflow. Existing commercial nuclear industry thermal-hydraulic codes were judged inadequate for detailed modeling of a Mk22 fuel assembly because the application involves a ribbed annular geometry, low pressure, downflow and an air-water mixture. FLOWTRAN-TF is a two-phase thermal-hydraulics code of similar technology to existing commercial codes such as RELAP and TRAC but customized for Savannah River Site applications. The main features and capabilities of FLOWTRAN-TF are detailed Mk22 fuel assembly ribbed annular geometry; conjugate heat transfer; detailed neutronic power distribution; three-dimensional heat conduction in Mk22 fuel and target tubes; two-dimensional coolant flow in channels (axial, azimuthal); single-phase and/or two-phase fluid (gas, liquid and/or gas-liquid); two-component (air, water); constitutive models applicable to low pressure air-water downflow in ribbed annular channels. The design of FLOWTRAN-TF is described in detail in this report which serves as the Software Design Report in accordance with Quality Assurance Procedure IV-4, Rev. 0 Software Design and Implementation'' in the 1Q34 manual.

  11. FLOWTRAN-TF software design

    SciTech Connect

    Aleman, S.E.; Flach, G.P.; Hamm, L.L.; Lee, S.Y.; Smith, F.G. III

    1993-02-01

    FLOWTRAN-TF was created to analyze an individual Mk22 fuel assembly during a large break Loss Of Coolant Accident (LOCA) scenario involving the Savannah River Site K-reactor after the initial few seconds of the transient. During the initial few seconds reactor cooling is limited by the static or Ledinegg flow instability phenomenon. The predecessor FLOWTRAN code was developed to analyze this portion of a LOCA. In the several seconds following the break, a significant fraction of the reactor coolant inventory leaks out the break, Emergency Cooling System (ECS) flow is initiated, and air enters the primary coolant circulation loops. Reactor fuel assemblies are cooled by a low flowrate air-water downflow. Existing commercial nuclear industry thermal-hydraulic codes were judged inadequate for detailed modeling of a Mk22 fuel assembly because the application involves a ribbed annular geometry, low pressure, downflow and an air-water mixture. FLOWTRAN-TF is a two-phase thermal-hydraulics code of similar technology to existing commercial codes such as RELAP and TRAC but customized for Savannah River Site applications. The main features and capabilities of FLOWTRAN-TF are detailed Mk22 fuel assembly ribbed annular geometry; conjugate heat transfer; detailed neutronic power distribution; three-dimensional heat conduction in Mk22 fuel and target tubes; two-dimensional coolant flow in channels (axial, azimuthal); single-phase and/or two-phase fluid (gas, liquid and/or gas-liquid); two-component (air, water); constitutive models applicable to low pressure air-water downflow in ribbed annular channels. The design of FLOWTRAN-TF is described in detail in this report which serves as the Software Design Report in accordance with Quality Assurance Procedure IV-4, Rev. 0 ``Software Design and Implementation`` in the 1Q34 manual.

  12. TF — EDRN Public Portal

    Cancer.gov

    TF, or transferrin, a glycoprotein with an approximate molecular weight of 76.5 kDa, is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum.

  13. Functional Characterization of the Alphavirus TF Protein

    PubMed Central

    Snyder, Jonathan E.; Kulcsar, Kirsten A.; Schultz, Kimberly L. W.; Riley, Catherine P.; Neary, Jacob T.; Marr, Scott; Jose, Joyce; Griffin, Diane E.

    2013-01-01

    Alphavirus dogma has long dictated the production of a discrete set of structural proteins during infection of a cell: capsid, pE2, 6K, and E1. However, bioinformatic analyses of alphavirus genomes (A. E. Firth, B. Y. Chung, M. N. Fleeton, and J. F. Atkins, Virol. J. 5:108, 2008) suggested that a ribosomal frameshifting event occurs during translation of the alphavirus structural polyprotein. Specifically, a frameshift event is suggested to occur during translation of the 6K gene, yielding production of a novel protein, termed transframe (TF), comprised of a C-terminal extension of the 6K protein in the −1 open reading frame (ORF). Here, we validate the findings of Firth and colleagues with respect to the production of the TF protein and begin to characterize the function of TF. Using a mass spectrometry-based approach, we identified TF in purified preparations of both Sindbis and Chikungunya virus particles. We next constructed a panel of Sindbis virus mutants with mutations which alter the production, size, or sequence of TF. We demonstrate that TF is not absolutely required in culture, although disrupting TF production leads to a decrease in virus particle release in both mammalian and insect cells. In a mouse neuropathogenesis model, mortality was <15% in animals infected with the TF mutants, whereas mortality was 95% in animals infected with the wild-type virus. Using a variety of additional assays, we demonstrate that TF retains ion-channel activity analogous to that of 6K and that lack of production of TF does not affect genome replication, particle infectivity, or envelope protein transit to the cell surface. The TF protein therefore represents a previously uncharacterized factor important for alphavirus assembly. PMID:23720714

  14. The ratio of sTfR/ferritin is associated with the expression level of TfR in rat bone marrow cells after endurance exercise.

    PubMed

    Tian, Ye; Zhao, Jiexiu; Zhao, Binxiu; Gao, Qi; Xu, Jincheng; Liu, Dongsen

    2012-06-01

    Currently, it is unclear which index of haematological parameters could be used to most easily monitor iron deficiency during endurance training. To address this question, 16 male Wistar rats were randomly assigned to two groups: a sedentary group (n = 8) and an exercised group (n = 8). Initially, animals in the exercise group started running on a treadmill at a rate of 30 m/min, on a 0% grade, for 1 min/session. Running time was gradually increased by 2 min/day. The training plan was one session per day during the initial 2 weeks and two sessions per day during the third to ninth week. At the end of the 9-week experiment, we analysed the blood of the experimental animals for haemoglobin levels, erythrocyte numbers, haematocrit, serum iron levels, total iron binding capacity, transferrin saturation, serum ferritin levels and soluble transferrin receptor (sTfR) levels, and we calculated the ratio of sTfR/ferritin. Erythrocyte numbers, haemoglobin levels and haematocrit values were decreased after 9 weeks of exercise, but sTfR and sTfR/ferritin values were increased (P < 0.01 or P < 0.05). The training regime significantly increased TfR mRNA levels in the bone marrow cells of the exercised rats compared with the sedentary group (1.8 ± 0.5 vs. 1.1 ± 0.2, P < 0.01). These results revealed a significant correlation between TfR levels in the bone marrow cells and the ratio of sTfR/ferritin (r = 0.517; P < 0.01) and sTfR levels (r = 0.206; P < 0.05) in sedentary and exercised rats. In conclusion, we show that sTfR indices and the ratio of sTfR/ferritin could be useful indicators for monitoring iron deficiency during endurance training. PMID:22207220

  15. Expression of antigen tf and galectin-3 in fibroadenoma

    PubMed Central

    2012-01-01

    Background Fibroadenomas are benign human breast tumors, characterized by proliferation of epithelial and stromal components of the terminal ductal unit. They may grow, regress or remain unchanged, as the hormonal environment of the patient changes. Expression of antigen TF in mucin or mucin-type glycoproteins and of galectin-3 seems to contribute to proliferation and transformations events; their expression has been reported in ductal breast cancer and in aggressive tumors. Findings Lectin histochemistry, immunohistochemistry, and immunofluorescence were used to examine the expression and distribution of antigen TF and galectin-3. We used lectins from Arachis hypogaea, Artocarpus integrifolia, and Amaranthus lecuocarpus to evaluate TF expression and a monoclonal antibody to evaluate galectin-3 expression. We used paraffin-embedded blocks from 10 breast tissues diagnosed with fibroadenoma and as control 10 healthy tissue samples. Histochemical and immunofluorescence analysis showed positive expression of galectin-3 in fibroadenoma tissue, mainly in stroma, weak interaction in ducts was observed; whereas, in healthy tissue samples the staining was also weak in ducts. Lectins from A. leucocarpus and A. integrifolia specificaly recognized ducts in healthy breast samples, whereas the lectin from A. hypogaea recognized ducts and stroma. In fibroadenoma tissue, the lectins from A. integrifolia, A. Hypogaea, and A. leucocarpus recognized mainly ducts. Conclusions Our results suggest that expression of antigen TF and galectin-3 seems to participate in fibroadenoma development. PMID:23265237

  16. Conclusions on Inclusion

    ERIC Educational Resources Information Center

    Fink, John

    2004-01-01

    An inclusion classroom is defined as one that is tasked with mainstreaming special education students into a population of general education students. In this brief article, the author, a high school mathematics teacher, shares his personal experiences in teaching in an inclusion classroom. A primary focus is his relationship with the special…

  17. Modulation of COUP-TF Expression in a Cnidarian by Ectopic Wnt Signalling and Allorecognition

    PubMed Central

    Duffy, David J.; Frank, Uri

    2011-01-01

    Background COUP transcription factors are required for the regulation of gene expression underlying development, differentiation, and homeostasis. They have an evolutionarily conserved function, being a known marker for neurogenesis from cnidarians to vertebrates. A homologue of this gene was shown previously to be a neuronal and nematocyte differentiation marker in Hydra. However, COUP-TFs had not previously been studied in a colonial cnidarian. Methodology/Principal Findings We cloned a COUP-TF homologue from the colonial marine cnidarian Hydractinia echinata. Expression of the gene was analysed during normal development, allorecognition events and ectopic Wnt activation, using in situ hybridisation and quantitative PCR. During normal Hydractinia development, the gene was first expressed in post-gastrula stages. It was undetectable in larvae, and its mRNA was present again in putative differentiating neurons and nematocytes in post-metamorphic stages. Global activation of canonical Wnt signalling in adult animals resulted in the upregulation of COUP-TF. We also monitored a strong COUP-TF upregulation in stolons undergoing allogeneic interactions. COUP-TF mRNA was most concentrated in the tissues that contacted allogeneic, non-self tissues, and decreased in a gradient away from the contact area. Interestingly, the gene was transiently upregulated during initial contact of self stolons, but dissipated rapidly following self recognition, while in non-self contacts high expression levels were maintained. Conclusions/Significance We conclude that COUP-TF is likely involved in neuronal/nematocyte differentiation in a variety of contexts. This has now been shown to include allorecognition, where COUP-TF is thought to have been co-opted to mediate allorejection by recruiting stinging cells that are the effectors of cytotoxic rejection of allogeneic tissue. Our findings that Wnt activation upregulates COUP-TF expression suggests that Wnts' role in neuronal differentiation

  18. Beginning without a Conclusion.

    ERIC Educational Resources Information Center

    Frazier, Richard

    1988-01-01

    Describes a series of activities without conclusions to introduce scientific reasoning in a ninth grade physical science course. Uses popcorn popping to get students to think about the concepts of graphing, histograms, frequency, probability, and scientific methodology. (CW)

  19. FLOWTRAN-TF code description. Revision 1

    SciTech Connect

    Flach, G.P.

    1991-09-01

    FLOWTRAN-TF is a two-component (air-water), two-phase thermal-hydraulics code designed for performing accident analyses of SRS reactor fuel assemblies during the Emergency Cooling System (ECS) phase of a Double Ended Guillotine Break (DEGB) Loss of Coolant Accident (LOCA). This report provides a brief description of the physical models in the version of FLOWTRAN-TF used to compute the Recommended K-Reactor Restart ECS Power Limit. This document is viewed as an interim report and should ultimately be superseded by a comprehensive user/programmer manual. In general, only high level discussions of governing equations and constitutive laws are presented. Numerical implementation of these models, code architecture and user information are not generally covered. A companion document describing code benchmarking is available.

  20. Functional divergence within class B MADS-box genes TfGLO and TfDEF in Torenia fournieri Lind

    PubMed Central

    Sasaki, Katsutomo; Aida, Ryutaro; Yamaguchi, Hiroyasu; Shikata, Masahito; Niki, Tomoya; Nishijima, Takaaki

    2010-01-01

    Homeotic class B genes GLOBOSA (GLO)/PISTILLATA (PI) and DEFICIENS (DEF)/APETALA3 (AP3) are involved in the development of petals and stamens in Arabidopsis. However, functions of these genes in the development of floral organs in torenia are less well known. Here, we demonstrate the unique floral phenotypes of transgenic torenia formed due to the modification of class B genes, TfGLO and TfDEF. TfGLO-overexpressing plants showed purple-stained sepals that accumulated anthocyanins in a manner similar to that of petals. TfGLO-suppressed plants showed serrated petals and TfDEF-suppressed plants showed partially decolorized petals. In TfGLO-overexpressing plants, cell shapes on the surfaces of sepals were altered to petal-like cell shapes. Furthermore, TfGLO- and TfDEF-suppressed plants partially had sepal-like cells on the surfaces of their petals. We isolated putative class B gene-regulated genes and examined their expression in transgenic plants. Three xyloglucan endo-1,4-beta-d-glucanase genes were up-regulated in TfGLO- and TfDEF-overexpressing plants and down-regulated in TfGLO- and TfDEF-suppressed plants. In addition, 10 anthocyanin biosynthesis-related genes, including anthocyanin synthase and chalcone isomerase, were up-regulated in TfGLO-overexpressing plants and down-regulated in TfGLO-suppressed plants. The expression patterns of these 10 genes in TfDEF transgenic plants were diverse and classified into several groups. HPLC analysis indicated that sepals of TfGLO-overexpressing plants accumulate the same type of anthocyanins and flavones as wild-type plants. The difference in phenotypes and expression patterns of the 10 anthocyanin biosynthesis-related genes between TfGLO and TfDEF transgenic plants indicated that TfGLO and TfDEF have partial functional divergence, while they basically work synergistically in torenia. Electronic supplementary material The online version of this article (doi:10.1007/s00438-010-0574-z) contains supplementary material, which

  1. Analysis of NSTX TF Joint Voltage Measurements

    SciTech Connect

    R, Woolley

    2005-10-07

    This report presents findings of analyses of recorded current and voltage data associated with 72 electrical joints operating at high current and high mechanical stress. The analysis goal was to characterize the mechanical behavior of each joint and thus evaluate its mechanical supports. The joints are part of the toroidal field (TF) magnet system of the National Spherical Torus Experiment (NSTX) pulsed plasma device operating at the Princeton Plasma Physics Laboratory (PPPL). Since there is not sufficient space near the joints for much traditional mechanical instrumentation, small voltage probes were installed on each joint and their voltage monitoring waveforms have been recorded on sampling digitizers during each NSTX ''shot''.

  2. Microparticle-associated tissue factor activity measured with the Zymuphen MP-TF kit and the calibrated automated thrombogram assay.

    PubMed

    Hellum, Marit; Øvstebø, Reidun; Trøseid, Anne-Marie S; Berg, Jens P; Brandtzaeg, Petter; Henriksson, Carola E

    2012-09-01

    There is increasing clinical interest for measuring microparticle (MP)-associated tissue factor (TF) activity owing to its possible role as a prothrombotic biomarker in a variety of diseases. However, the methods used are to various extents hampered by lack of (pre)analytical standardization as well as limited published documentation. The objective of this study was to evaluate the performance of the Zymuphen MP-TF kit and the calibrated automated thrombogram (CAT) assay in measuring MP-associated TF activity in plasma using a Neisseria meningitidis (Nm)-stimulated whole blood model. In addition, (pre)analytical variables like centrifugation procedures, freezing/thawing and the effect of addition of exogenous phosphatidylserine in plasma were evaluated in the CAT assay. Citrate-anticoagulated blood was stimulated with Nm bacteria for 4 h before platelet-poor plasma (PPP) or platelet-free plasma (PFP) were prepared and assayed with either of the two methods. Nm dose-dependently (10-10 bacteria/ml) induced TF-specific activity, measured as decreased lagtimes, in the CAT assay. The Zymuphen MP-TF kit also detected TF activity, although much higher Nm doses (10 bacteria/ml) were required to achieve measurable levels. Neither freezing/thawing nor the use of PPP vs. PFP influenced the TF activity, measured over a broad range of lagtimes, in the CAT assay. In conclusion, changes in lagtime in the CAT assay reflected levels of MP-associated TF activity in a more sensitive manner than the Zymuphen MP-TF kit did, in our Nm-stimulated whole blood system. PMID:22732249

  3. Conclusion

    NASA Astrophysics Data System (ADS)

    Ivancevic, Vladimir G.; Reid, Darryn J.

    2015-11-01

    It is often held that things should always be made simple, which presumes that either that they can always be made simple or that all the jetisoned logic doesn't matter anyway. Alledgedly, anything should be explainable so that anyone can understand it. Don't get bogged down in dreary details. It should be effortless for the reader: low-dimensional systems exhibit complex behaviour while high-dimensional systems exhibit simple behaviour (to return to our prolegomonal opening), competition is a universal solution, demand must increase as price falls, and everything under the sun neatly fits a power law. Or so the story goes...

  4. Conclusion

    NASA Technical Reports Server (NTRS)

    Arnold, Steven M.; Wong, Terry T.

    2011-01-01

    This compilation of papers in this book represents approximately half of the works discussed at the MS&T 2010 symposium entitled Tools, Models, Databases, and Simulation Tools Developed and Needed to Realize the Vision of Integrated Computational Materials Engineering at Materials Science & Technology wherein five sessions comprised of 33 presentations was organized. The goal of the symposium was two fold To provide a forum in which current state-of-the-art methods for ICME (e.g., information informatics, experimentation, and modeling) could be openly discussed and critiqued by not only materials scientist but also structural engineers/researchers, component designers, industrial leaders and government program managers. To leave the symposium and in particular the panel discussion with a clear idea of the gaps and barriers (both technical, cultural and economical) that must be addressed in order for ICME to fully succeed. The organizers felt that these goals were met, as particularly evident by the standing room only attendance during a lively panel discussion session at the end of the Symposium. However it is the firm belief of the editors of this book that this symposium was merely a start in the right direction, and that subsequent conferences/symposium (e.g., First World Congress on Integrated Computational Materials Engineering to be held July 10-14, 2011 at Seven Springs Mountain Resort in Pennsylvania) must work hard to ensure that a truly diverse, multidisciplinary, community of researchers and practitioners are present and have ample opportunity for interaction. This will ensure that a proper balance between push and pull disciplines and technologies is maintained so that this emerging focus area, Integrated Computational Materials Engineering (ICME), has the greatest potential for success and impact on "system-level" payoffs. Similarly, a pro-active approach is required to reform historical modes of operation in industry, government and the academic sectors so as to facilitate multidisciplinary collaboration and to clearly articulate the vision and scope of ICME.

  5. Conclusion

    NASA Astrophysics Data System (ADS)

    Thoma, Klaus; Hiller, Daniel; Leismann, Tobias; Drees, Birgit

    Considering the breadth of perspectives in security research among Europeans, as exemplified within this publication, one may certainly note that a tremendous development of this young discipline has occurred in a short period of time. Only three years have passed since the discipline was promoted to an individual theme within the specific programme on `Cooperation' of the European Commission FP7. Since then, a conceptual framework has been established and the first collaborative projects have been executed on different levels, all at an impressive pace. Although the future of security research will remain closely linked to the political will of EU member states, the established base will serve as a solid foundation for the further development of the discipline on a European scale.

  6. A-10/TF34 Turbine Engine Monitoring System (TEMS)

    NASA Technical Reports Server (NTRS)

    Christopher, R. G.

    1981-01-01

    The hardware and software development of the A-10/TF34 turbine engine monitoring system (TEMS) is described. The operation and interfaces of the A-10/TF34 TEMS hardware are discussed with particular emphasis on function, capabilities, and limitations. The TEMS data types are defined and the various data acquisition modes are explained. Potential data products are also discussed.

  7. FLOWTRAN-TF v1.2 source code

    SciTech Connect

    Aleman, S.E.; Cooper, R.E.; Flach, G.P.; Hamm, L.L.; Lee, S.; Smith, F.G. III

    1993-02-01

    The FLOWTRAN-TF code development effort was initiated in early 1989 as a code to monitor production reactor cooling systems at the Savannah River Plant. This report is a documentation of the various codes that make up FLOWTRAN-TF.

  8. FLOWTRAN-TF v1. 2 source code

    SciTech Connect

    Aleman, S.E.; Cooper, R.E.; Flach, G.P.; Hamm, L.L.; Lee, S.; Smith, F.G. III.

    1993-02-01

    The FLOWTRAN-TF code development effort was initiated in early 1989 as a code to monitor production reactor cooling systems at the Savannah River Plant. This report is a documentation of the various codes that make up FLOWTRAN-TF.

  9. Itpr3 Is responsible for the mouse tufted (tf) locus.

    PubMed

    Ellis, Hillary T; Tordoff, Michael G; Parker, M Rockwell

    2013-03-01

    The tf (tufted) locus is responsible for a classic phenotype of hair loss and regrowth in mice. It is a characteristic of the BTBR strain. Here, we use a combination of positional cloning methods and complementation mapping to identify Itpr3, the inositol triphosphate receptor type 3, as the gene responsible for the tf locus. PMID:23100490

  10. High expression of COUP-TF II cooperated with negative Smad4 expression predicts poor prognosis in patients with colorectal cancer

    PubMed Central

    Wang, Chaoqun; Zhou, Yun; Ruan, Ruoyun; Zheng, Maojin; Han, Wencan; Liao, Linchuan

    2015-01-01

    Objective: In order to evaluate whether the role of chicken ovalbumin upstream promoter transcription factor II (COUP-TF II) could sever as a predictor to stratify risk of human colorectal cancer (CRC) patients, and to elucidate the preliminary molecular mechanisms of COUP-TF II involved in the development and advancement of CRC reflected by investigating the relationship of COUP-TF II with PTEN, Smad4. Methods: 112 cases tissue microarray and immunohistochemical SP method were used to detect the expression of COUP-TF II, PTEN and Smad4 in CRC tissues and adjacent non-tumorous tissues. The clinical relevance and prognosis of COUP-TF II, PTEN, Smad4 in CRC patients were analyzed. Furthermore, Cox proportional hazards model was performed to indicate the independent prognostic factors for CRC patients using various clinicopathological parameters and COUP-TF II, PTEN and Smad4. Results: COUP-TF II proteins were positively expressed in 65.2% of CRC tissues and 15.5% paired non-CRC tissues, respectively. The expression of COUP-TF II was significantly correlated with TNM stage and lymph node metastasis and a negative correlation with Smad4 expression. Patients bearing higher levels of COUP-TF II expression showed lower DFS and OS. Most importantly, Cox proportional hazards regression analyses showed COUP-TF II positive/Smad4 negative status (DFS, P=0.001; OS, P=0.005) were independent prognostic factors for CRC patients. Conclusion: Positive COUP-TF II expression levels has significant value in determining CRC stage and metastasis and cooperates with negative Smad4 expression contributing to assess prognosis in patients with colorectal cancer, suggesting Smad4 may be involved in the above regulation progress probably. PMID:26261604

  11. Personalization.

    ERIC Educational Resources Information Center

    Shore, Rebecca Martin

    1996-01-01

    Describes how a typical high school in Huntington Beach, California, curbed disruptive student behavior by personalizing the school experience for "problem" students. Through mostly volunteer efforts, an adopt-a-kid program was initiated that matched kids' learning styles to adults' personality styles and resulted in fewer suspensions and numerous…

  12. Comparative Evaluation of Tubex TF (Inhibition Magnetic Binding Immunoassay) for Typhoid Fever in Endemic Area

    PubMed Central

    Khanna, Menka; Gill, Karamjit Singh

    2015-01-01

    Background Typhoid fever remains a significant health problem in endemic countries like India. Various serological tests for the diagnosis of typhoid fever are available commercially. We assessed the usefulness of rapid test based on magnetic particle separation to detect Immunoglobulin against Salmonella typhi O9 lipopolysaccharide. Aim Aim of this study was to compare the sensitivity and specificity of widal test, typhidot and tubex TF test for the diagnosis of typhoid fever in an endemic country like India. Materials and Methods Serum samples collected from 50 patients of typhoid fever, 50 patients of non typhoid fever and 100 normal healthy individuals residing in Amritsar were subjected to widal test, typhidot test and tubex TF test as per manufacturer’s instructions. Data collected was assessed to find sensitivity and specificity of these tests in an endemic area. Results Significant widal test results were found positive in 68% of patients of typhoid fever and only 4% of non typhoid fever patients. Typhidot (IgM or IgG) was positive in 72% of typhoid fever patients and 10% and 6% in non typhoid fever and normal healthy individuals respectively. Tubex TF showed higher sensitivity of 76% and specificity of 96-99% which was higher than typhidot and comparable to widal test. Conclusion This was the first evaluation of rapid tubex TF test in northern India. In countries which can afford high cost of test, tubex TF should be recommended for the diagnosis in acute stage of the disease in clinical setting. However, there is urgent need for a highly specific and sensitive test for the diagnosis of typhoid fever in clinical settings in endemic areas. PMID:26676104

  13. TF ripple loss of alpha particles in TFTR DT experiments

    SciTech Connect

    Redi, M.H.; Budny, R.V.; Darrow, D.S.

    1995-08-01

    Quantitative evaluation of TF ripple loss of DT alpha particles is a central issue for reactor design because of potentially severe first wall heat load problems. DT experiments on TFTR allow experimental measurements to be compared to modeling of the underlying alpha physics, with code validation an important goal. Modeling of TF ripple loss of alphas in TFTR now includes neoclassical calculations of alpha losses arising from first orbit loss, stochastic ripple diffusion, ripple trapping and collisional effects. Recent Hamiltonian coordinate guiding center code (ORBIT) simulations for TFTR have shown that collisions enhance the stochastic TF ripple losses at TFTR. A faster way to simulate experiment has been developed and is discussed here which uses a simple stochastic domain model for TF ripple loss within the TRANSP analysis code.

  14. BOREAS TF-9 SSA-OBS Branch Level Flux Data

    NASA Technical Reports Server (NTRS)

    Rayment, Mark B.; Jarvis, Paul G.; Hall, Forrest G. (Editor); Huemmrich, Karl (Editor)

    2000-01-01

    The BOREAS TF-9 team collected data that describe carbon dioxide and water vapor fluxes from foliage at the BOREAS SSA-OBS site from 07-April through 23-November-1996. The data are available in tabular ASCII files.

  15. Quantum dot based fluorometric detection of cancer TF-antigen.

    PubMed

    Li, Nan; Chow, Ari M; Ganesh, Hashwin V S; Brown, Ian R; Kerman, Kagan

    2013-10-15

    Cancer is a major global health challenge that would benefit from advances in screening methods for early detection that are rapid and low cost. TF-antigen is a tumor-associated antigen displayed on cell surface proteins of a high percentage of human carcinomas. Here we present a fluorometric bioassay for TF-antigen (galactose-β-(1→3)-N-acetyl-d-galactosamine) that utilizes quantum dot (QD) technology coupled with magnetic beads for rapid detection of TF-antigen at high sensitivity (10(-7) M range). In the competitive bioassay, 4-aminophenyl β-d-galactopyranoside (4-APG) conjugated to QDs competes with TF-antigen for binding sites on peanut agglutinin (PNA) that is immobilized on magnetic beads. The bioassay is specific and ultrasensitive in the environment of complex protein mixtures, demonstrating its potential applicability for the screening of clinical samples. PMID:23980999

  16. Development of Jacketing Technologies for Iter CS and TF Conductor

    NASA Astrophysics Data System (ADS)

    Hamada, K.; Nakajima, H.; Matsui, K.; Kawano, K.; Takano, K.; Tsutsumi, F.; Okuno, K.; Teshima, O.; Soejima, K.

    2008-03-01

    The Japan Atomic Energy Agency (JAEA) has developed jacketing technologies for ITER Toroidal Field (TF) and Central Solenoid (CS) conductor. Full scale TF and CS conduits were fabricated using carbon-reduced SUS316LN and boron-added (˜40 ppm) high manganese stainless steel (0.025C -22Mn -13Cr -9Ni -0.12N: JK2LB), respectively. Welding condition was optimized so that back bead does not interfere a cable insertion. The weld joint samples were compacted by a compaction machine that was newly constructed and tested at 4.2 K. Mechanical characteristics at 4K of CS, TF conduits and CS welded joint satisfied ITER mechanical requirements. TF welded joint shows slightly lower value of 0.2% yield strength (885 MPa) than that of ITER requirement (900 MPa). The TF conduit contains nitrogen content of 0.14%, which is minimum value in ITER specification. The lower nitrogen content may be caused by the release of nitrogen from molten metal during non-filler welding resulting in a 4 K strength decrease. To satisfy the ITER requirements, minimum nitrogen contents of conduit should be increased from 0.14% to 0.15% at least. Therefore, JAEA successfully developed TF and CS conduits with welding technologies and finalized the procurement specification for ITER conductor jacketing.

  17. TF Inner Leg Space Allocation for Pilot Plant Design Studies

    SciTech Connect

    Peter H. Titus and Ali Zolfaghari

    2012-09-06

    A critical design feature of any tokamak is the space taken up by the inner leg of the toroidal field (TF) coil. The radial build needed for the TF inner leg, along with shield thickness , size of the central solenoid and plasma minor radius set the major radius of the machine. The cost of the tokamak core roughly scales with the cube of the major radius. Small reductions in the TF build can have a big impact on the overall cost of the reactor. The cross section of the TF inner leg must structurally support the centering force and that portion of the vertical separating force that is not supported by the outer structures. In this paper, the TF inner leg equatorial plane cross sections are considered. Out-of- Plane (OOP) forces must also be supported, but these are largest away from the equatorial plane, in the inner upper and lower corners and outboard sections of the TF coil. OOP forces are taken by structures that are not closely coupled with the radial build of the central column at the equatorial plane. The "Vertical Access AT Pilot Plant" currently under consideration at PPPL is used as a starting point for the structural, field and current requirements. Other TF structural concepts are considered. Most are drawn from existing designs such as ITER's circular conduits in radial plates bearing on a heavy nose section, and TPX's square conduits in a case, Each of these concepts can rely on full wedging, or partial wedging. Vaulted TF coils are considered as are those with some component of bucking against a central solenoid or bucking post. With the expectation that the pilot plant will be a steady state machine, a static stress criteria is used for all the concepts. The coils are assumed to be superconducting, with the superconductor not contributing to the structural strength. Limit analysis is employed to assess the degree of conservatism in the static criteria as it is applied to a linear elastic stress analysis. TF concepts, and in particular the PPPL AT

  18. TF-Test Modified: New Diagnostic Tool for Human Enteroparasitosis.

    PubMed

    Carvalho, Juliana Barboza de; Santos, Bianca Martins Dos; Gomes, Jancarlo Ferreira; Suzuki, Celso Tetsuo Nagase; Hoshino Shimizu, Sumie; Falcão, Alexandre Xavier; Pierucci, Julia Cestari; Matos, Lucas Vinicius Shigaki de; Bresciani, Katia Denise Saraiva

    2016-07-01

    Intestinal parasitosis is highly prevalent worldwide, being among the main causes of illness and death in humans. Currently, laboratory diagnosis of the intestinal parasites is accomplished through manual technical procedures, mostly developed decades ago, which justifies the development of more sensitive and practical techniques. Therefore, the main objective of this study was to develop, evaluate, and validate a new parasitological technique referred to as TF-Test Modified, in comparison to three conventional parasitological techniques: TF-Test Conventional; Rugai, Mattos & Brisola; and Helm Test/Kato-Katz. For this realization, we collected stool samples from 457 volunteers located in endemic areas of Campinas, São Paulo, Brazil, and statistically compared the techniques. Intestinal protozoa and helminths were detected qualitatively in 42.23% (193/457) of the volunteers by TF-Test Modified technique, against 36.76% (168/457) by TF-Test Conventional, 5.03% (23/457) by Helm Test/Kato-Katz, and 4.16% (19/457) by Rugai, Mattos & Brisola. Furthermore, the new technique presented "almost perfect kappa" agreement in all evaluated parameters with 95% (P < 0.05) of estimation. The current study showed that the TF-Test Modified technique can be comprehensively used in the diagnosis of intestinal protozoa and helminths, and its greater diagnostic sensitivity should help improving the quality of laboratory diagnosis, population surveys, and control of intestinal parasites. PMID:25968065

  19. Conclusions. [hydrogen-based energy

    NASA Technical Reports Server (NTRS)

    1975-01-01

    Conclusions are presented according to general areas of technology with some specific examples of research and technology needs identified. These conclusions provide a base for the future development of detailed program plans and identify research needs that are not being given attention or are not being supported at a sufficient level. Emphasis is placed on hydrogen production and use.

  20. Joule heating of the ITER TF cold structure: Effects of vertical control coil currents and ELMS

    SciTech Connect

    Radovinsky, A.; Pillsbury, R.D. Jr.

    1993-11-09

    The toroidal field coil and support structures for ITER are maintained at cryogenic temperatures. The time-varying currents in the poloidal field coil system will induce eddy currents in these structures. The associated Joule dissipation will cause local heating and require heat removal which will show up as a load on the cryogenic system. Studies of Joule heating of the ITER TF cold structure (TFCS) due to the currents in the poloidal field coil system are presented. The two regimes considered in this study are the plasma vertical stability control and the Edge Loss Mode (ELM) events. The 3-D, thin-shell, eddy current program, EDDYCUFF was used to analyze the eddy currents and Joule losses in the cold structure. The current versus time scenarios were defined. Four control coil options were studied. All schemes use coils external to the TF cold structure. Analyses of power depositions during the plasma vertical stability control were performed for each of the four options. For each of these options three different recovery times were assumed. The times were 3, 1, and 1/3 seconds. Sets of four sequential ELMs, as well as isolated ELMs have been studied for various sets of active PF coils. The results showed that the lowest average power dissipation in the TF cold structure occurs when a subset of PF2 and PF7 are active, and all the other PF coils are passive. The general conclusion is that to minimize power dissipation in the TF cold structure it is preferable that only coils PF2 and PF7 are active. The other coils (PF3-PF6) should be passive and driven by a condition of constant flux. It is recommended in particular, that coils PF3 and PF5 be allowed to change currents to conserve flux, since they provide the maximum shielding of the TFCS from the fields caused by the active coils.

  1. BOREAS TF-11 Decomposition Data over the SSA-Fen

    NASA Technical Reports Server (NTRS)

    Valentine, David W.; Hall, Forrest G. (Editor); Conrad, Sara (Editor)

    2000-01-01

    The BOREAS TF-11 team collected several data sets in its efforts to fully describe the flux and site characteristics at the SSA-Fen site. This data set contains decomposition rates of a standard substrate (wheat straw) across treatments. The measurements were conducted in 1994 as part of a 2 x 2 factorial experiment in which we added carbon (300 g/sq m as wheat straw) and nitrogen (6 g/sq m as urea) to four replicate locations in the vicinity of the TF-11 tower. The data are stored in tabular ASCII files.

  2. BOREAS TF-11 Biomass Data over the SSA-Fen

    NASA Technical Reports Server (NTRS)

    Valentine, David W.; Hall, Forrest G. (Editor); Conrad, Sara (Editor)

    2000-01-01

    The BOREAS TF-11 team collected several data sets in its efforts to fully describe the flux and site characteristics at the SSA-Fen site. This data set contains plant cover, standing crop of plant biomass, and estimated net primary productivity at each chamber site at the end of the 1994 field season. The measurements were conducted as part of a 2 x 2 factorial experiment in which we added carbon (300 g/sq m as wheat straw) and nitrogen (6 g/sq m as urea) to four replicate locations in the vicinity of the TF-11 tower. The data are stored in tabular ASCII files.

  3. Conclusion: challenges for the future

    PubMed Central

    North, D. Warner

    1993-01-01

    The title “Challenges for the Future” implies the challenge to summarize a very complex meeting. Of necessity, I will present a personal impression. My interest is in risk assessment, which I define as a process for summarizing science in support of decision making. Risk assessment is sometimes regarded as arcane numerology, a rigid process of computing risk numbers in which much available science is unused. I am a strong advocate for the broader definition of risk assessment. It is encouraging to learn how much science is becoming available for use in risk assessment for gasoline, its components, and alternative fuels. PMID:17539103

  4. Conclusion: challenges for the future.

    PubMed

    North, D W

    1993-12-01

    The title "Challenges for the Future" implies the challenge to summarize a very complex meeting. Of necessity, I will present a personal impression. My interest is in risk assessment, which I define as a process for summarizing science in support of decision making. Risk assessment is sometimes regarded as arcane numerology, a rigid process of computing risk numbers in which much available science is unused. I am a strong advocate for the broader definition of risk assessment. It is encouraging to learn how much science is becoming available for use in risk assessment for gasoline, its components, and alternative fuels. PMID:17539103

  5. BOREAS TF-1 SSA-OA Soil Characteristics Data

    NASA Technical Reports Server (NTRS)

    Black, T. Andrew; Chen, Z; Nesic, Z.; Hall, Forrest G. (Editor); Papagno, Andrea (Editor)

    2000-01-01

    The BOREAS TF-1 team collected several data sets in support of its efforts to characterize and interpret soil information at the SSA-OA tower site in 1994 as part of BOREAS. Data sets collected include soil respiration, temperature, moisture, and gravimetric data. The data are stored in tabular ASCII format.

  6. An Information-Theoretic Perspective of Tf-idf Measures.

    ERIC Educational Resources Information Center

    Aizawa, Akiko

    2003-01-01

    Presents a mathematical definition of the probability-weighted amount of information (PWI), a measure of term specificity in documents that is based on an information-theoretic view of retrieval events. Corresponds with the term frequency-inverse document frequency (tf-idf) measures that are used in information retrieval systems. (Author/LRW)

  7. Conclusive exclusion of quantum states

    NASA Astrophysics Data System (ADS)

    Bandyopadhyay, Somshubhro; Jain, Rahul; Oppenheim, Jonathan; Perry, Christopher

    2014-02-01

    In the task of quantum state exclusion, we consider a quantum system prepared in a state chosen from a known set. The aim is to perform a measurement on the system which can conclusively rule that a subset of the possible preparation procedures cannot have taken place. We ask what conditions the set of states must obey in order for this to be possible and how well we can complete the task when it is not. The task of quantum state discrimination forms a subclass of this set of problems. Within this paper, we formulate the general problem as a semidefinite program (SDP), enabling us to derive sufficient and necessary conditions for a measurement to be optimal. Furthermore, we obtain a necessary condition on the set of states for exclusion to be achievable with certainty, and we give a construction for a lower bound on the probability of error. This task of conclusively excluding states has gained importance in the context of the foundations of quantum mechanics due to a result from Pusey, Barrett, and Rudolph (PBR). Motivated by this, we use our SDP to derive a bound on how well a class of hidden variable models can perform at a particular task, proving an analog of Tsirelson's bound for the PBR experiment and the optimality of a measurement given by PBR in the process. We also introduce variations of conclusive exclusion, including unambiguous state exclusion, and state exclusion with worst-case error.

  8. BOREAS TF-11 SSA-Fen Leaf Gas Exchange Data

    NASA Technical Reports Server (NTRS)

    Arkebauer, Timothy J.; Hall, Forrest G. (Editor); Knapp, David E. (Editor)

    2000-01-01

    The BOREAS TF-11 team gathered a variety of data to complement its tower flux measurements collected at the SSA-Fen site. This data set contains single-leaf gas exchange data from the SSA-Fen site during 1994 and 1995. These leaf gas exchange properties were measured for the dominant vascular plants using portable gas exchange systems. The data are stored in tabular ASCII files.

  9. TF34 Quiet Nacelle nearfield acoustic test results

    NASA Technical Reports Server (NTRS)

    Coward, W. E.; Smith, E. B.; Sowers, H. D.

    1974-01-01

    The results of the nearfield acoustic tests conducted on the TF34 Quiet Nacelle are presented. The high fan noise suppression levels being sought (26 PNdB reduction in aft noise) necessitated the use of an extensive system of special nearfield acoustic instrumentation to properly evaluate the suppression achieved. The design, operation, and test results from each of these nearfield acoustic instrumentation systems are presented.

  10. TF41 Engine Fan Disk Seeded Fault Crack Propagation Test

    NASA Technical Reports Server (NTRS)

    Lewicki, David G.

    2003-01-01

    Uncontained engine failures, although rare in occurrence, can have a catastrophic effect on aircraft performance and safety. Engine disk cracks can eventually lead to these type of failures. A number of techniques to detect engine disk cracks have been developed in recent years. However, these technologies have only been validated by disk spin pit tests, not actual engine tests. Due to this, a project was established to perform seeded fault engine tests on a TF41 engine disk fan. A defect was machined in the first stage fan disk of a TF41 engine. The disk was run in a spin pit to initiate a crack. Once initiated, the disk was run in an actual engine test facility. The engine was cycled by a number of start and stops with the goal of propagating the crack to disk burst through low cycle fatigue. Various crack detection techniques were installed on the engine and run real-time during the test to validate their abilities to detect disk cracks. These techniques were based on methods such as change in mass imbalance using vibration or shaft displacement, change in blade position, acoustic emission, and torsional resonance. At the completion of 4474 test cycles, the crack in the TF41 disk was determined to have grown approximately 0.025 inches. This was far less the predicted crack growth based on a fracture mechanics analysis and finite element stress analysis.

  11. Targeted delivery of siRNA to activated T cells via transferrin-polyethylenimine (Tf-PEI) as a potential therapy of asthma.

    PubMed

    Xie, Yuran; Kim, Na Hyung; Nadithe, Venkatareddy; Schalk, Dana; Thakur, Archana; Kılıç, Ayşe; Lum, Lawrence G; Bassett, David J P; Merkel, Olivia M

    2016-05-10

    Asthma is a worldwide health problem. Activated T cells (ATCs) in the lung, particularly T helper 2 cells (Th2), are strongly associated with inducing airway inflammatory responses and chemoattraction of inflammatory cells in asthma. Small interfering RNA (siRNA) as a promising anti-sense molecule can specifically silence inflammation related genes in ATCs, however, lack of safe and efficient siRNA delivery systems limits the application of siRNA as a therapeutic molecule in asthma. Here, we designed a novel pulmonary delivery system of siRNA, transferrin-polyethylenimine (Tf-PEI), to selectively deliver siRNA to ATCs in the lung. Tf-PEI polyplexes demonstrated optimal physicochemical properties such as size, distribution, zeta-potential, and siRNA condensation efficiency. Moreover, in vitro studies showed significantly enhanced cellular uptake and gene knockdown mediated by Tf-PEI polyplexes in human primary ATCs. Biodistribution of polyplexes in a murine asthmatic model confirmed that Tf-PEI polyplexes can efficiently and selectively deliver siRNA to ATCs. In conclusion, the present work proves the feasibility to target ATCs in asthma via Tf receptor. This strategy could potentially be used to design an efficient siRNA delivery system for asthma therapy. PMID:27001893

  12. Identifying TF-MiRNA Regulatory Relationships Using Multiple Features

    PubMed Central

    Shao, Mingyu; Sun, Yanni; Zhou, Shuigeng

    2015-01-01

    MicroRNAs are known to play important roles in the transcriptional and post-transcriptional regulation of gene expression. While intensive research has been conducted to identify miRNAs and their target genes in various genomes, there is only limited knowledge about how microRNAs are regulated. In this study, we construct a pipeline that can infer the regulatory relationships between transcription factors and microRNAs from ChIP-Seq data with high confidence. In particular, after identifying candidate peaks from ChIP-Seq data, we formulate the inference as a PU learning (learning from only positive and unlabeled examples) problem. Multiple features including the statistical significance of the peaks, the location of the peaks, the transcription factor binding site motifs, and the evolutionary conservation are derived from peaks for training and prediction. To further improve the accuracy of our inference, we also apply a mean reciprocal rank (MRR)-based method to the candidate peaks. We apply our pipeline to infer TF-miRNA regulatory relationships in mouse embryonic stem cells. The experimental results show that our approach provides very specific findings of TF-miRNA regulatory relationships. PMID:25922940

  13. Tensile tests of ITER TF conductors jacket materials

    NASA Astrophysics Data System (ADS)

    Anashkin, O. P.; Kеilin, V. E.; Krivykh, A. V.; Diev, D. N.; Dinisilov, A. S.; Shcherbakov, V. I.; Tronza, V. I.

    2012-06-01

    The set of very tough requirements has been formulated for TF jacket materials with extremely high plasticity at liquid helium temperature. The stainless steel 316LN-IG is recommended to be used for TF jacket tubes. Samples of 316LN-IG tubes (whole tubes and sub-size samples) made of the material from the same electro slag remelt have been tested in different conditions - as received tubes and tubes after prescribed compaction, 2.5% deformation at room temperature and heat treatment at 650 0C, 200 hours. The tensile tests were carried out at room, liquid nitrogen and liquid helium temperatures down to 4.2 K, meeting corresponding ASME and ASTM requirements. The low temperature testing devices are described. The tests results for sub-size samples and whole tubes show that the latter tests are considerably more representative and important for butt weld qualification at LHe temperature. It was observed that the ferromagnetic properties of all samples and especially of butt welds increase with lowering the temperature and increasing the degree of deformation. At LHe temperature a non-uniform and highly localized serrated deformations were observed.

  14. High frequency dynamic engine simulation. [TF-30 engine

    NASA Technical Reports Server (NTRS)

    Schuerman, J. A.; Fischer, K. E.; Mclaughlin, P. W.

    1977-01-01

    A digital computer simulation of a mixed flow, twin spool turbofan engine was assembled to evaluate and improve the dynamic characteristics of the engine simulation to disturbance frequencies of at least 100 Hz. One dimensional forms of the dynamic mass, momentum and energy equations were used to model the engine. A TF30 engine was simulated so that dynamic characteristics could be evaluated against results obtained from testing of the TF30 engine at the NASA Lewis Research Center. Dynamic characteristics of the engine simulation were improved by modifying the compression system model. Modifications to the compression system model were established by investigating the influence of size and number of finite dynamic elements. Based on the results of this program, high frequency engine simulations using finite dynamic elements can be assembled so that the engine dynamic configuration is optimum with respect to dynamic characteristics and computer execution time. Resizing of the compression systems finite elements improved the dynamic characteristics of the engine simulation but showed that additional refinements are required to obtain close agreement simulation and actual engine dynamic characteristics.

  15. The Scorpion Toxin Tf2 from Tityus fasciolatus Promotes Nav1.3 Opening

    PubMed Central

    Camargos, Thalita S.; Bosmans, Frank; Rego, Solange C.; Mourão, Caroline B. F.; Schwartz, Elisabeth F.

    2015-01-01

    We identified Tf2, the first β-scorpion toxin from the venom of the Brazilian scorpion Tityus fasciolatus. Tf2 is identical to Tb2-II found in Tityus bahiensis. We found that Tf2 selectively activates human (h)Nav1.3, a neuronal voltage-gated sodium (Nav) subtype implicated in epilepsy and nociception. Tf2 shifts hNav1.3 activation voltage to more negative values, thereby opening the channel at resting membrane potentials. Seven other tested mammalian Nav channels (Nav1.1-1.2; Nav1.4-1.8) expressed in Xenopus oocytes are insensitive upon application of 1 μM Tf2. Therefore, the identification of Tf2 represents a unique addition to the repertoire of animal toxins that can be used to investigate Nav channel function. PMID:26083731

  16. Expression of Thomsen-Friedenreich (TF) antigens on lymphocytes. II. Loss of cryptic TF antigens during mitogenic activation of human T and B lymphocytes.

    PubMed

    Wolf, M F; Schmitt, H R; Schumacher, K

    1989-07-01

    Human peripheral blood lymphocytes (HPBL) were examined for the presence of cryptic Thomsen-Friedenreich (TF) antigens as detected by PNA or an anti-TF mAb (49H8) after neuraminidase treatment of the cell surface. Neither PNA nor the mAb bound to the cells before treatment with neuraminidase. After removal of surface sialic acid, all lymphocytes were PNA-reactive, and 85% of HPBL reacted with the mAb 49H8. Seventy-seven percent of nylon wool (NW)-eluted T cells (96% Leu 1+), 80% of enriched helper T cells (83% Leu 3a+), and 78% of suppressor/cytotoxic T cells (63% Leu 2a+) carried the cryptic TF determinant recognized by the mAb 49H8. Ninety-one percent of NW-adherent cells (68% Leu 10+, 5% Leu 1+) were also TF positive. In contrast to NW-eluted T cells which showed low to moderate mAb 49H8 binding, 48% of NW-adherent cells revealed strong binding of anti-TF mAb. With progressive activation of T cells by PHA, binding of mAb to the cryptic TF antigen completely disappeared on blast cells. The presence of TF antigens on small cells in the culture was only poorly affected. The same was observed for activation of B cells with PWM. On the other hand, binding sites for PNA did not change during blastogenesis. The disappearance of the particular, mAb 49H8-reactive TF antigen on T blast cells is not due to the loss of antigen in a distinct T cell subset, but occurs to an equal extent in the helper and suppressor/cytotoxic T cell subpopulations. Thus, the majority of peripheral T and B lymphocytes carries cryptic TF antigens. Activated T or B cell blasts, on the other hand, are deficient for the particular TF antigen detected by the mAb 49H8. We interpret these data as a modulation of certain TF antigens on effector cells in the course of lymphocyte activation. PMID:2786763

  17. A distinct model of synergism between a processive endocellulase (TfCel9A) and an exocellulase (TfCel48A) from Thermobifida fusca.

    PubMed

    Kostylev, Maxim; Wilson, David

    2014-01-01

    Lignocellulosic biomass is digested in nature by the synergistic activities of enzymes with complementary properties, and understanding synergistic interactions will improve the efficiency of industrial biomass use for sustainable fuels and chemicals. Cel9A and Cel48A from a model bacterium, Thermobifida fusca (TfCel9A and TfCel48A, respectively), are two cellulases with different properties and have previously been shown to synergize well with each other. TfCel9A is a processive endocellulase with relatively high activity on crystalline cellulose. TfCel48A is a reducing end-directed exocellulase with very low activity on crystalline cellulose. Neither enzyme fits its respective role in the classical synergism model of enzymatic cellulose digestion. Using the results of time course, endpoint, and sequential addition activity assays, we propose a model of synergistic cooperation between the two cellulases. TfCel9A is most effective on fresh bacterial cellulose with a presumably uniform surface at the molecular level. Its processive activity likely erodes the surface and thus reduces its own activity. TfCel48A is able to hydrolyze the TfCel9A-modified substrate efficiently and replenish the uniform surface required by TfCel9A, creating a feedback mechanism. The model of synergistic interactions is comparable to an earlier proposed model for Trichoderma reesei Cel7A and Cel7B, but the roles of endo- and exocellulases are reversed, a finding which suggests that bacteria and fungi may have evolved different approaches to efficient biomass degradation. PMID:24162578

  18. 40 CFR Table 1 to Subpart Ll of... - Potline TF Limits for Emission Averaging

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 10 2011-07-01 2011-07-01 false Potline TF Limits for Emission Averaging 1 Table 1 to Subpart LL of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Reduction Plants Pt. 63, Subpt. LL, Table 1 Table 1 to Subpart LL of Part 63—Potline TF Limits for...

  19. 40 CFR Table 1 to Subpart Ll of... - Potline TF Limits for Emission Averaging

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 11 2014-07-01 2014-07-01 false Potline TF Limits for Emission Averaging 1 Table 1 to Subpart LL of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Reduction Plants Pt. 63, Subpt. LL, Table 1 Table 1 to Subpart LL of Part 63—Potline TF Limits for...

  20. 40 CFR Table 1 to Subpart Ll of... - Potline TF Limits for Emission Averaging

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 11 2013-07-01 2013-07-01 false Potline TF Limits for Emission Averaging 1 Table 1 to Subpart LL of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Reduction Plants Pt. 63, Subpt. LL, Table 1 Table 1 to Subpart LL of Part 63—Potline TF Limits for...

  1. 40 CFR Table 1 to Subpart Ll of... - Potline TF Limits for Emission Averaging

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 11 2012-07-01 2012-07-01 false Potline TF Limits for Emission Averaging 1 Table 1 to Subpart LL of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Reduction Plants Pt. 63, Subpt. LL, Table 1 Table 1 to Subpart LL of Part 63—Potline TF Limits for...

  2. 40 CFR Table 1 to Subpart Ll of... - Potline TF Limits for Emission Averaging

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 10 2010-07-01 2010-07-01 false Potline TF Limits for Emission Averaging 1 Table 1 to Subpart LL of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Reduction Plants Pt. 63, Subpt. LL, Table 1 Table 1 to Subpart LL of Part 63—Potline TF Limits for...

  3. Draft Whole-Genome Sequence of the Type Strain Bacillus aquimaris TF12T

    PubMed Central

    Hernández-González, Ismael L.

    2016-01-01

    Bacillus aquimaris TF12 is a Gram-positive bacteria isolated from a tidal flat of the Yellow Sea in South Korea. We report the draft whole-genome sequence of Bacillus aquimaris TF12, the type strain of a set of bacteria typically associated with marine habitats and with a potentially high biotechnology value. PMID:27417832

  4. Molecular mechanisms of COUP-TF-mediated transcriptional repression: evidence for transrepression and active repression.

    PubMed Central

    Leng, X; Cooney, A J; Tsai, S Y; Tsai, M J

    1996-01-01

    COUP-TF, an orphan member of the nuclear receptor superfamily, has been proposed to play a key role in regulating organogenesis, neurogenesis, and cellular differentiation during embryonic development. Since heterodimierization is a common theme within the nuclear receptor superfamily and has been demonstrated to modulate transcriptional properties of heterodimeric partners via allosteric interactions, we have devised a strategy to examine the silencing function of COUP-TF in a heterodimeric context. We find that the intrinsic active repression function of COUP-TF is not affected by heterodimerization. Moreover, COUP-TF can transrepress the ligand-dependent activation of its heterodimeric partners without its own DNA binding site. Using receptor deletion mutants in transfection assays, we show that the region necessary for COUP-TF silencing function is not sufficient for its transrepression activity. Furthermore, our studies indicate that in addition to its active repression function, COUP-TF can repress several different types of activator-dependent transactivation. However, this active repression function of COUP-TF may be differentially regulated by some other activator(s). These studies provide new insights into the molecular mechanism(s) of COUP-TF-mediated repression. PMID:8628300

  5. Draft Whole-Genome Sequence of the Type Strain Bacillus aquimaris TF12T.

    PubMed

    Hernández-González, Ismael L; Olmedo-Álvarez, Gabriela

    2016-01-01

    Bacillus aquimaris TF12 is a Gram-positive bacteria isolated from a tidal flat of the Yellow Sea in South Korea. We report the draft whole-genome sequence of Bacillus aquimaris TF12, the type strain of a set of bacteria typically associated with marine habitats and with a potentially high biotechnology value. PMID:27417832

  6. Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes

    SciTech Connect

    Qiu, Y.; Krishnan, V.; Zeng, Z.

    1995-09-01

    Chicken ovalbumin upstream promoter transcription factors (COUP-TFs) are orphan members of the steroid/thyroid hormone receptor superfamily. COUP-TF homologues have been cloned in many species, from Drosophila to human. The protein sequences of COUP-TFs are highly homologous across species, suggesting functional conservation. Two COUP-TF genes have been cloned from human, and their genomic organizations have been characterized. To determine whether the genomic organization is conserved between human and mouse, we isolated two mouse COUP-TF genes (I and II) and characterized their genomic structures. Both genes have relatively simple structures that are similar to those of their human counterparts. In addition, we mapped mouse COUP-TF I to the distal region of chromosome 13 and COUP-TF II to the central region of chromosome 7. Furthermore, we mapped human COUP-TF I to 5q14 of chromosome 5 and COUP-TF II to 15q26 of chromosome 15. The results demonstrate that COUP-TF genes are located in chromosomal regions that are syntenic between mouse and human. 25 refs., 5 figs.

  7. Identification of Tf1 integration events in S. pombe under nonselective conditions.

    PubMed

    Cherry, Kristina E; Hearn, Willis E; Seshie, Osborne Y K; Singleton, Teresa L

    2014-06-01

    Integration of retroviral elements into the host genome is a phenomena observed among many classes of retroviruses. Much information concerning the integration of retroviral elements has been documented based on in vitro analysis or expression of selectable markers. To identify possible Tf1 integration events within silent regions of the Schizosaccharomyces pombe genome, we focused on performing an in vivo genome-wide analysis of Tf1 integration events from the nonselective phase of the retrotransposition assay. We analyzed 1000 individual colonies streaked from four independent Tf1 transposed patches under nonselection conditions. Our analysis detected a population of G418(S)/neo(+) Tf1 integration events that would have been overlooked during the selective phase of the assay. Further RNA analysis from the G418(S)/neo(+) clones revealed 50% of clones expressing the neo selectable marker. Our data reveals Tf1's ability to insert within silent regions of S. pombe's genome. PMID:24680781

  8. Partial characterization of horse transferrin heterogeneity with respect to the atypical type, Tf C.

    PubMed

    Stratil, A; Glasnák, V

    1981-01-01

    In starch gel electrophoresis of horse sera each transferrin variant is formed by a strong anodal band and a weaker cathodal band. An 'atypical' Tf C, has two zones of about equal intensity. Family data show that Tf C is genetically controlled by an allele Tf C at the Tf locus. Frequencies of transferrin alleles in various horse breeds are also presented. After isolation and fractionation of individual transferrin variants (Tf O, Tf D, Tf C) on DEAE-Sephadex, additional weak bands were detected. The two main zones of each variant were isolated in a pure state and treated with neuraminidase. In all three variants studied the electrophoretic mobility of the slower band (2a) was decreased in two steps, and the faster band (4b) in four steps. The mobilities of hands derived from the fast zone (4b) were slower than mobilities of corresponding bands derived from the slow zone (2a). These results suggest the presence of two sialic acid residues in the slow zone, and of four residues in the fast zone. Residual heterogeneity was independent of sialic acid. PMID:7283207

  9. Tf-PEG-PLL-PLGA nanoparticles enhanced chemosensitivity for hypoxia-responsive tumor cells

    PubMed Central

    Liu, Ping; Zhang, Haijun; Wu, Xue; Guo, Liting; Wang, Fei; Xia, Guohua; Chen, Baoan; Yin, HaiXiang; Wang, Yonglu; Li, Xueming

    2016-01-01

    Hypoxia is an inseparable component of the solid tumor as well as the bone marrow microenvironment. In this study, we investigated the effect of the novel polyethylene glycol (PEG)-poly L-lysine (PLL)-poly lactic-co-glycolic acid (PLGA) based nanoparticles (NPs) modified by transferrin (Tf) loaded with daunorubicin (DNR) (DNR-Tf-PEG-PLL-PLGA-NPs, abbreviated as DNR-Tf-NPs) on leukemia cells (K562) under hypoxia. In vitro and in vivo tests to determine the effect of the enhanced chemosensitivity were evaluated using the immunofluorescence, flow cytometry, 3,-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-tetrazoliumbromide assay, Western blot analysis, histopathological examination, and immunohistochemistry analysis. Under hypoxia, K562 cells were hypoxia-responsive with the inhibitory concentration 50% (IC50) of DNR increased, resulting in chemotherapy insensitivity. By targeting the transferrin receptor (TfR) on the surface of K562 cells, DNR-Tf-NPs led to an increased intracellular DNR level, enhancing drug sensitivity of K562 cells to DNR with a decreased IC50, even under hypoxia. We further detected the protein levels of hypoxia-inducible factor-1α (HIF-1α), Bcl-2, Bax, and caspase-3 in K562 cells. The results indicated that DNR-Tf-NPs downregulated HIF-1α and induced apoptosis to overcome hypoxia. In the xenograft model, injection of DNR-Tf-NPs significantly suppressed tumor growth, and the immunosignals of Ki67 in DNR-Tf-NPs group was significantly lower than the other groups. It was therefore concluded that DNR-Tf-NPs could be a promising candidate for enhancing drug sensitivity under hypoxia in tumor treatment. PMID:27574446

  10. Tf-PEG-PLL-PLGA nanoparticles enhanced chemosensitivity for hypoxia-responsive tumor cells.

    PubMed

    Liu, Ping; Zhang, Haijun; Wu, Xue; Guo, Liting; Wang, Fei; Xia, Guohua; Chen, Baoan; Yin, HaiXiang; Wang, Yonglu; Li, Xueming

    2016-01-01

    Hypoxia is an inseparable component of the solid tumor as well as the bone marrow microenvironment. In this study, we investigated the effect of the novel polyethylene glycol (PEG)-poly L-lysine (PLL)-poly lactic-co-glycolic acid (PLGA) based nanoparticles (NPs) modified by transferrin (Tf) loaded with daunorubicin (DNR) (DNR-Tf-PEG-PLL-PLGA-NPs, abbreviated as DNR-Tf-NPs) on leukemia cells (K562) under hypoxia. In vitro and in vivo tests to determine the effect of the enhanced chemosensitivity were evaluated using the immunofluorescence, flow cytometry, 3,-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-tetrazoliumbromide assay, Western blot analysis, histopathological examination, and immunohistochemistry analysis. Under hypoxia, K562 cells were hypoxia-responsive with the inhibitory concentration 50% (IC50) of DNR increased, resulting in chemotherapy insensitivity. By targeting the transferrin receptor (TfR) on the surface of K562 cells, DNR-Tf-NPs led to an increased intracellular DNR level, enhancing drug sensitivity of K562 cells to DNR with a decreased IC50, even under hypoxia. We further detected the protein levels of hypoxia-inducible factor-1α (HIF-1α), Bcl-2, Bax, and caspase-3 in K562 cells. The results indicated that DNR-Tf-NPs downregulated HIF-1α and induced apoptosis to overcome hypoxia. In the xenograft model, injection of DNR-Tf-NPs significantly suppressed tumor growth, and the immunosignals of Ki67 in DNR-Tf-NPs group was significantly lower than the other groups. It was therefore concluded that DNR-Tf-NPs could be a promising candidate for enhancing drug sensitivity under hypoxia in tumor treatment. PMID:27574446

  11. Improvements, enhancements, and optimizations of COBRA-TF

    SciTech Connect

    Salko, R. K.; Avramova, M. N.; Hooper, R.; Palmtag, S.; Popov, E.; Turner, J.

    2013-07-01

    The Reactor Dynamics and Fuel Management Group (RDFMG) at The Pennsylvania State University (PSU) has become active in the Consortium for Advanced Simulation of Light Water Reactors (CASL) program by delivering, supporting, and further developing CTF, the PSU version of the Coolant Boiling in Rod Arrays - Two Fluids (COBRA-TF) Thermal/Hydraulic (T/H), sub-channel program. New development work on CTF was primarily geared towards decreasing the execution time of the code so that it may eventually be used for performing pin-by-pin, full-core simulations. Great gains have been made through targeting sections of source code for optimization. For example, wall clock time has been reduced for a one-assembly, three-dimensional model, containing {approx}9,400 mesh cells, from 9.2 min to 1 min. A further improvement has been reduction in code memory usage, which was previously prohibitive for large models. In conjunction with the run time speedups, this has enabled the simulation of a refined quarter-core model ({approx}460,000 mesh cells), which saw a reduction in memory usage from over 130 GB to less than 3 GB. In addition to the optimization work, RDFMG has also created a preprocessor utility for the fast and less error-prone generation of CTF input decks. Furthermore, basic post-processing capabilities have been implemented by creating a CTF subroutine for producing Visualization Tool-Kit (VTK) files that output mesh data and associated simulation results. These VTK files can be opened with visualization software. (authors)

  12. Advanced development of the spectrum sciences Model 5005-TF, single-event test fixture

    SciTech Connect

    Ackermann, M.R.; Browning, J.S. ); Hughlock, B.W. ); Lum, G.K. ); Tsacoyeanes, W.C. Lab., Inc., Cambridge, MA ); Weeks, M.D. )

    1990-09-01

    This report summarizes the advanced development of the Spectrum Sciences Model 5005-TF, Single-Event Test Fixture. The Model 5005-TF uses a Californium-252 (Cf-252) fission-fragment source to test integrated circuits and other devices for the effects of single-event phenomena. Particle identification methods commonly used in high-energy physics research and nuclear engineering have been incorporated into the Model 5005-TF for estimating the particle charge, mass, and energy parameters. All single-event phenomena observed in a device under test (DUT) are correlated with an identified fission fragment, and its linear energy transfer (LET) and range in the semiconductor material of the DUT.

  13. Early Flight Fission Test Facilities (EFF-TF) To Support Near-Term Space Fission Systems

    NASA Astrophysics Data System (ADS)

    van Dyke, Melissa

    2004-02-01

    Through hardware based design and testing, the EFF-TF investigates fission power and propulsion component, subsystems, and integrated system design and performance. Through demonstration of systems concepts (designed by Sandia and Los Alamos National Laboratories) in relevant environments, previous non-nuclear tests in the EFF-TF have proven to be a highly effective method (from both cost and performance standpoint) to identify and resolve integration issues. Ongoing research at the EFF-TF is geared towards facilitating research, development, system integration, and system utilization via cooperative efforts with DOE labs, industry, universities, and other NASA centers. This paper describes the current efforts for 2003.

  14. Modelling TF ripple loss of alpha particles in TFTR DT experiments

    SciTech Connect

    Redi, M.H.; Budny, R.V.; Darrow, D.S.

    1995-07-01

    Modelling of TF ripple loss of alphas in DT experiments on TFTR now includes neoclassical calculations of first orbit loss, stochastic ripple diffusion, ripple trapping and collisional effects. A rapid way to simulate experiment has been developed which uses a simple stochastic domain model for TF ripple loss within the TRANSP analysis code, with the ripple diffusion threshold evaluated by comparison with more accurate but computationally expensive Hamiltonian coordinate guiding center code simulations. Typical TF collisional ripple loss predictions are 6-10% loss of alphas for TFTR D-T experiments at I{sub p} = 1.0-2.0 MA and R = 2.52 m.

  15. Early Flight Fission Test Facilities (EFF-TF) To Support Near-Term Space Fission Systems

    SciTech Connect

    Van Dyke, Melissa

    2004-02-04

    Through hardware based design and testing, the EFF-TF investigates fission power and propulsion component, subsystems, and integrated system design and performance. Through demonstration of systems concepts (designed by Sandia and Los Alamos National Laboratories) in relevant environments, previous non-nuclear tests in the EFF-TF have proven to be a highly effective method (from both cost and performance standpoint) to identify and resolve integration issues. Ongoing research at the EFF-TF is geared towards facilitating research, development, system integration, and system utilization via cooperative efforts with DOE labs, industry, universities, and other NASA centers. This paper describes the current efforts for 2003.

  16. COUP-TF gene: a structure unique for the steroid/thyroid receptor superfamily.

    PubMed Central

    Ritchie, H H; Wang, L H; Tsai, S; O'Malley, B W; Tsai, M J

    1990-01-01

    Two different genomic genes for the COUP-transcription factor, COUP-TF I and COUP-TF II, have been isolated from a human cosmid genomic library using a [32P]-labeled cDNA probe. Data obtained from Southern blot analysis of these cosmid clones indicated that two closely related genes exist in the human genome and have a similar genomic organization. The genes are similar in the hormone and DNA binding domains but diverge from one another in the N-terminal region. Using DNA sequencing and polymerase chain reaction (PCR) techniques we have determined that the structure of COUP-TF I consists only of three exons and two introns. Surprisingly, both zinc fingers (i.e., F1 and F2) are located in the first exon. Therefore, COUP-TF I is unique among the members of the steroid/thyroid hormone receptor superfamily which have been described to date. Images PMID:2263450

  17. Fission yeast retrotransposon Tf1 integration is targeted to 5′ ends of open reading frames

    PubMed Central

    Behrens, Ralf; Hayles, Jacky; Nurse, Paul

    2000-01-01

    Target site selection of transposable elements is usually not random but involves some specificity for a DNA sequence or a DNA binding host factor. We have investigated the target site selection of the long terminal repeat-containing retrotransposon Tf1 from the fission yeast Schizosaccharomyces pombe. By monitoring induced transposition events we found that Tf1 integration sites were distributed throughout the genome. Mapping these insertions revealed that Tf1 did not integrate into open reading frames, but occurred preferentially in longer intergenic regions with integration biased towards a region 100–420 bp upstream of the translation start site. Northern blot analysis showed that transcription of genes adjacent to Tf1 insertions was not significantly changed. PMID:11095681

  18. BOREAS TF-11 SSA-Fen 1995 Leaf Area Index Data

    NASA Technical Reports Server (NTRS)

    Arkebauer, Timothy J.; Hall, Forrest G. (Editor); Knapp, David E. (Editor)

    2000-01-01

    The BOREAS TF-11 team gathered a variety of data to complement its tower flux measurements collected at the SSA-Fen site. These data are LAI measurements made by the TF-11 team throughout the 1995 growing season. The data include the LAI of plants that fall into six categories: total, Carex spp., Betula pumila, Menyanthes trifoliata, Salix spp., and other vascular plants. The data are stored in tabular ASCII files.

  19. TfNHNHBoc as a Trifluoromethylating Agent for Vicinal Difunctionalization of Terminal Alkenes.

    PubMed

    Guo, Jing-Yu; Wu, Ruo-Xin; Jin, Ji-Kang; Tian, Shi-Kai

    2016-08-01

    An unprecedented application of trifluoromethanesulfonyl hydrazides as trifluoromethylating agents has been demonstrated in two vicinal difunctionalization reactions of terminal alkenes: the copper-catalyzed three-component vicinal chlorotrifluoromethylation of arylakenes with TfNHNHBoc and NaCl and the tandem trifluoromethylation/cyclization of N-arylacrylamides with TfNHNHBoc. The reactions proceeded in the presence of inexpensive oxidants under mild conditions and provided a range of structurally diverse trifluoromethyl-containing compounds with high regioselectivity. PMID:27414955

  20. Addressing safety liabilities of TfR bispecific antibodies that cross the blood-brain barrier.

    PubMed

    Couch, Jessica A; Yu, Y Joy; Zhang, Yin; Tarrant, Jacqueline M; Fuji, Reina N; Meilandt, William J; Solanoy, Hilda; Tong, Raymond K; Hoyte, Kwame; Luk, Wilman; Lu, Yanmei; Gadkar, Kapil; Prabhu, Saileta; Ordonia, Benjamin A; Nguyen, Quyen; Lin, Yuwen; Lin, Zhonghua; Balazs, Mercedesz; Scearce-Levie, Kimberly; Ernst, James A; Dennis, Mark S; Watts, Ryan J

    2013-05-01

    Bispecific antibodies using the transferrin receptor (TfR) have shown promise for boosting antibody uptake in brain. Nevertheless, there are limited data on the therapeutic properties including safety liabilities that will enable successful development of TfR-based therapeutics. We evaluate TfR/BACE1 bispecific antibody variants in mouse and show that reducing TfR binding affinity improves not only brain uptake but also peripheral exposure and the safety profile of these antibodies. We identify and seek to address liabilities of targeting TfR with antibodies, namely, acute clinical signs and decreased circulating reticulocytes observed after dosing. By eliminating Fc effector function, we ameliorated the acute clinical signs and partially rescued a reduction in reticulocytes. Furthermore, we show that complement mediates a residual decrease in reticulocytes observed after Fc effector function is eliminated. These data raise important safety concerns and potential mitigation strategies for the development of TfR-based therapies that are designed to cross the blood-brain barrier. PMID:23636093

  1. The Relation of the Level of Serum Anti-TF, -Tn and -Alpha-Gal IgG to Survival in Gastrointestinal Cancer Patients

    PubMed Central

    Smorodin, Eugeniy; Sergeyev, Boris; Klaamas, Kersti; Chuzmarov, Valentin; Kurtenkov, Oleg

    2013-01-01

    Objective: To evaluate the relation of the level of serum anti-TF, -Tn and -αGal carbohydrate antibodies to survival in gastrointestinal cancer patients. Methods: The level of anti-TF (Thomsen-Friedenreich antigen), -Tn and -αGal IgG was analysed in the serum of patients with gastric (n = 83) and colorectal (n = 51) cancers in the long-term follow-up, using ELISA with polyacrylamide glycoconjugates. To evaluate overall survival and the risk of death, the Kaplan-Meier method and the Cox proportional hazards model were used in the univariate analysis of patients groups. Results: A significantly better survival was observed: (1) in patients with an increased level of anti-TF antibodies (all, stage III, T2-4, N1-2 and G3; P = 0.004-0.038, HR = 0.16-0.46); and (2) in patients with an increased level of anti-Tn antibodies (G1-2 tumors; P = 0.034-0.042, HR = 0.34-0.47). A significantly worse survival was observed in gastrointestinal, gastric and colorectal groups with an increased level of serum anti-αGal antibodies. This association depended on the patho-morphology of tumors (all, stages I-II, III, T2-4, N0, N1-2 and G1-2; P = 0.006-0.048, HR = 1.99-2.33). In the combined assessment of the anti-TF and -αGal antibodies level of the whole gastrointestinal group (n = 53), P = 0.002, HR = 0.25, 95% CI 0.094-0.655. In the follow-up, the survival time was shorter in patients whose level of anti-αGal antibodies rose (P = 0.009-0.040, HR = 2.18-4.27). The level of anti-TF antibodies inversely correlated with neutrophil/lymphocyte ratio (NLR, r = - 0.401, P = 0.004, n = 49). Patients with a higher level of anti-αGal antibodies and NLR values demonstrated a significantly worse survival (P = 0.009, HR = 2.98, n = 48). Conclusions: The preoperative levels of anti-TF, -Tn and -αGal antibodies and their dynamics are of prognostic significance. The method for the determination of circulating anti-carbohydrate antibodies may be a useful supplement in clinical outcome assessment

  2. 4.11 Summary and Conclusions

    NASA Astrophysics Data System (ADS)

    Noßke, D.; Mattsson, S.; Johansson, L.

    This document is part of Subvolume A 'Fundamentals and Data in Radiobiology, Radiation Biophysics, Dosimetry and Medical Radiological Protection' of Volume 7 'Medical Radiological Physics' of Landolt-Börnstein - Group VIII 'Advanced Materials and Technologies'. It contains the Section '4.11 Summary and Conclusions' of the Chapter '4 Dosimetry in Nuclear Medicine Diagnosis and Therapy'.

  3. Impact of several reactor features on TF coil design for TPSS

    SciTech Connect

    Miller, J.R.; Bulmer, R.H.

    1986-03-26

    A significant driver of machine size in previous designs was the amount of nuclear shielding placed between the blanket and the toroidal field (TF) coils to minimize the radiation heating and damage in these critical components. Of course the total amount of shielding is not arbitrary; it certainly must adequately suppress radiation outside the plant. However, if all of this shielding were contained inside the TF coils, several parameters (coil size and weight, maximum field at the windings, stored energy, etc.) would become inordinately large. Reducing the amount of shielding inside the TF coils and allowing the radiation load to climb to less ''conventional'' levels could pay big benefits in reducing the machine size, so long as the damage and heat load remain tolerable. Recent studies indicate that superconducting windings in TF coils can accept much higher heat loads than have been previously considered and simultaneously can be designed with higher than conventional current densities. The purpose of the present exercise is to probe the limits of acceptable radiation levels in relation to winding pack current densities in the TF coils for reactor relevant designs.

  4. SM-TF: A structural database of small molecule-transcription factor complexes.

    PubMed

    Xu, Xianjin; Ma, Zhiwei; Sun, Hongmin; Zou, Xiaoqin

    2016-06-30

    Transcription factors (TFs) are the proteins involved in the transcription process, ensuring the correct expression of specific genes. Numerous diseases arise from the dysfunction of specific TFs. In fact, over 30 TFs have been identified as therapeutic targets of about 9% of the approved drugs. In this study, we created a structural database of small molecule-transcription factor (SM-TF) complexes, available online at http://zoulab.dalton.missouri.edu/SM-TF. The 3D structures of the co-bound small molecule and the corresponding binding sites on TFs are provided in the database, serving as a valuable resource to assist structure-based drug design related to TFs. Currently, the SM-TF database contains 934 entries covering 176 TFs from a variety of species. The database is further classified into several subsets by species and organisms. The entries in the SM-TF database are linked to the UniProt database and other sequence-based TF databases. Furthermore, the druggable TFs from human and the corresponding approved drugs are linked to the DrugBank. © 2016 Wiley Periodicals, Inc. PMID:27010673

  5. Estimation of Theaflavins (TF) and Thearubigins (TR) Ratio in Black Tea Liquor Using Electronic Vision System

    NASA Astrophysics Data System (ADS)

    Akuli, Amitava; Pal, Abhra; Ghosh, Arunangshu; Bhattacharyya, Nabarun; Bandhopadhyya, Rajib; Tamuly, Pradip; Gogoi, Nagen

    2011-09-01

    Quality of black tea is generally assessed using organoleptic tests by professional tea tasters. They determine the quality of black tea based on its appearance (in dry condition and during liquor formation), aroma and taste. Variation in the above parameters is actually contributed by a number of chemical compounds like, Theaflavins (TF), Thearubigins (TR), Caffeine, Linalool, Geraniol etc. Among the above, TF and TR are the most important chemical compounds, which actually contribute to the formation of taste, colour and brightness in tea liquor. Estimation of TF and TR in black tea is generally done using a spectrophotometer instrument. But, the analysis technique undergoes a rigorous and time consuming effort for sample preparation; also the operation of costly spectrophotometer requires expert manpower. To overcome above problems an Electronic Vision System based on digital image processing technique has been developed. The system is faster, low cost, repeatable and can estimate the amount of TF and TR ratio for black tea liquor with accuracy. The data analysis is done using Principal Component Analysis (PCA), Multiple Linear Regression (MLR) and Multiple Discriminate Analysis (MDA). A correlation has been established between colour of tea liquor images and TF, TR ratio. This paper describes the newly developed E-Vision system, experimental methods, data analysis algorithms and finally, the performance of the E-Vision System as compared to the results of traditional spectrophotometer.

  6. The role of TF- and Tn-antigens in breast cancer metastasis.

    PubMed

    Kölbl, Alexandra C; Jeschke, Udo; Friese, Klaus; Andergassen, Ulrich

    2016-06-01

    Almost 40 years ago, researchers found out that the Thomsen-Friedenreich (TF) and the Thomsen nouvelle (Tn) antigens could be detected in carcinoma, but not in healthy tissue. A short time after that it became clear that TF and Tn are precursor molecules of the MN-blood group antigens. In normal tissue TF and Tn are coated by glycosyl structures, thereby forming the glycoproteins which are known to account for the MN-blood group, but in malignant tissue these molecules are uncovered.TF, which has an additional Galectin-residue compared to Tn, is correlated with a more favourable prognosis for patients. On the contrary, patients with Tn-bearing tissues have a worse prognosis for overall and progression-free survival. It is known that TF and Tn are involved in the adhesion of tumour cells to the endothelium via a mechanism recruiting Galectin-3 and MUC-1, which is the first step in metastasis formation. Furthermore, it became clear that this pathway can be blocked by a growing number of molecules, thereby creating ways of therapeutical intervention. PMID:26758176

  7. ScerTF: a comprehensive database of benchmarked position weight matrices for Saccharomyces species

    PubMed Central

    Spivak, Aaron T.; Stormo, Gary D.

    2012-01-01

    Saccharomyces cerevisiae is a primary model for studies of transcriptional control, and the specificities of most yeast transcription factors (TFs) have been determined by multiple methods. However, it is unclear which position weight matrices (PWMs) are most useful; for the roughly 200 TFs in yeast, there are over 1200 PWMs in the literature. To address this issue, we created ScerTF, a comprehensive database of 1226 motifs from 11 different sources. We identified a single matrix for each TF that best predicts in vivo data by benchmarking matrices against chromatin immunoprecipitation and TF deletion experiments. We also used in vivo data to optimize thresholds for identifying regulatory sites with each matrix. To correct for biases from different methods, we developed a strategy to combine matrices. These aligned matrices outperform the best available matrix for several TFs. We used the matrices to predict co-occurring regulatory elements in the genome and identified many known TF combinations. In addition, we predict new combinations and provide evidence of combinatorial regulation from gene expression data. The database is available through a web interface at http://ural.wustl.edu/ScerTF. The site allows users to search the database with a regulatory site or matrix to identify the TFs most likely to bind the input sequence. PMID:22140105

  8. Identification, modification, and implementation of an evidence-based psychotherapy for children in a low-income country: the use of TF-CBT in Zambia

    PubMed Central

    2013-01-01

    Background The need to address the treatment gap in mental health services in low- and middle-income countries (LMIC) is well recognized and particularly neglected among children and adolescents. Recent literature with adult populations suggests that evidence-based mental health treatments are effective, feasible, and cross-culturally modifiable for use in LMIC. This paper addresses a gap in the literature documenting pre-trial processes. We describe the process of selecting an intervention to meet the needs of a particular population and the process of cross-cultural adaptation. Methods Community-based participatory research principles were implemented for intervention selection, including joint meetings with stakeholders, review of qualitative research, and review of the literature. Trauma-focused Cognitive Behavioral Therapy (TF-CBT) was chosen as the evidence-based practice for modification and feasibility testing. The TF-CBT adaptation process, rooted within an apprenticeship model of training and supervision, is presented. Clinical case notes were reviewed to document modifications. Results Choosing an intervention can work as a collaborative process with community involvement. Results also show that modifications were focused primarily on implementation techniques rather than changes in TF-CBT core elements. Conclusions Studies documenting implementation processes are critical to understanding why intervention choices are made and how the adaptations are generated in global mental health. More articles are needed on how to implement evidence-based treatments in LMIC. PMID:24148551

  9. Design and Synthesis of Phenylpyrrolidine Phenylglycinamides As Highly Potent and Selective TF-FVIIa Inhibitors

    PubMed Central

    2013-01-01

    Inhibitors of the Tissue Factor/Factor VIIa (TF-FVIIa) complex are promising novel anticoagulants that show excellent efficacy and minimal bleeding in preclinical models. On the basis of a zwitterionic phenylglycine acylsulfonamide 1, a phenylglycine benzylamide 2 was shown to possess improved permeability and oral bioavailability. Optimization of the benzylamide, guided by X-ray crystallography, led to a potent TF-FVIIa inhibitor 18i with promising oral bioavailability, but promiscuous activity in an in vitro safety panel of receptors and enzymes. Introducing an acid on the pyrrolidine ring, guided by molecular modeling, resulted in highly potent, selective, and efficacious TF-FVIIa inhibitors with clean in vitro safety profile. The pyrrolidine acid 20 showed a moderate clearance, low volume of distribution, and a short t1/2 in dog PK studies. PMID:24900796

  10. Innovative out-of-plane support of TF coils and implication to fusion core maintenance

    SciTech Connect

    Bromberg, L.; Titus, P.

    1996-12-31

    To improve scheduled and unscheduled maintenance of the nuclear island, methods of supporting the out-of-plane TF loads so as not to interfere with maintenance operation would be highly desirable. Even if the toroidal field coil were extended outwardly to allow for maintenance to toroidally segmented modules, ideally there should not be structures in between coils in the outboard legs of the toroidal field coil. The number of these modules is the same as the number of toroidal field coils, and therefore one and only one module is removed between a pair of adjacent TF coils. Structural analyses of several cases that have the common feature of avoiding material in between the outer legs of the TF coil are presented in this paper. The implications on the structural amount of material required are investigated. 2 refs., 6 figs., 1 tab.

  11. Use of BODIPY-Cholesterol (TF-Chol) for Visualizing Lysosomal Cholesterol Accumulation.

    PubMed

    Hölttä-Vuori, Maarit; Sezgin, Erdinc; Eggeling, Christian; Ikonen, Elina

    2016-09-01

    Dipyrromethene difluoride-cholesterol (TopFluor-Cholesterol, TF-Chol) is a widely used cholesterol analogue due to its excellent fluorescence properties and considerable similarity with natural cholesterol in terms of membrane partitioning. However, the suitability of TF-Chol for detecting lysosomal cholesterol deposition has recently been questioned. Here, we highlight the fact that the method of lipid delivery and the analysis of time-point both affect the membrane distribution and labeling pattern of TF-Chol, similarly as with radiolabeled cholesterol. Lysosomal sterol accumulation characteristic to a lysosomal storage disease is most readily detected when the probe is introduced via the physiological route, i.e. as a sterol fatty acid ester in low-density lipoprotein particles. When administered to cells from solvent, lysosomal sterol sequestration becomes evident after an overnight equilibration between membranes. PMID:27187581

  12. Analysis on damage to TF coils of a compact reversed shear tokamak CREST

    NASA Astrophysics Data System (ADS)

    Huang, Q.; Zheng, S.; Lu, L.; Zeng, Q.; Hiwatari, R.; Asaoka, Y.; Okano, K.; Ogawa, Y.

    2007-08-01

    CREST is a conceptual tokamak reactor design with high β plasma, high thermal efficiency, competitive cost and water-cooled ferritic steel components. Some of its parameters are similar to those of the ITER advanced mode plasma. In this manuscript, the specific issues and analysis on damage to TF coils of CREST were carried out based on the three-dimensional model of the CREST with the widely used code MCNP/4C and the IAEA latest released FENDL/2.1 data library. Damage to some specific regions of the TF coils near large openings and at the inboard mid-plane are calculated and analyzed. Parameters such as the distributions of nuclear heat density, fast neutron flux, dose rate to the epoxy insulator, and peak displacement dose to Cu conductor for the TF coil near these regions were calculated and analyzed. The shield thicknesses at these regions are optimized.

  13. Development of bending characteristics for the TPX TF magnet coil cable-in-conduit conductor

    SciTech Connect

    Grut, K.E.; Holbrook, R.L.; Hook, E.; Antaya, T.A.

    1996-12-31

    The conductor for the toroidal field (TF) magnet coils for the Tokamak Physics experiment (TPX) is an assembly of stranded Nb{sub 3}Sn superconductor sheathed by an Incoloy 908 conduit. The coil shape, when coupled with stiffness of the cable-in-conduit conductor (CICC) is such that conventional magnet winding techniques cannot be utilized. Therefore a bending and forming method will be employed in the TF coils. The cable will be reacted after bending because the reaction process hardens the conduit and also lowers the strain the cable can withstand without performance degradation. The Incoloy 908 conduit also work hardens quickly, necessitating the production of the required coil shape in one step without correction. This paper discusses the limiting processes for forming the TPX TF magnet geometry, the methods utilized in establishing the CICC bending characteristics and the methods employed to account for material springback so that a coil can be manufactured accurately and efficiently.

  14. Evaluation of a novel kit (TF-Test) for the diagnosis of intestinal parasitic infections.

    PubMed

    Gomes, Jancarlo Ferreira; Hoshino-Shimizu, Sumie; Dias, Luiz Cândido S; Araujo, Ana Júlia S A; Castilho, Vera L P; Neves, Fátima A M A

    2004-01-01

    Intestinal parasitic infections are currently a source of concern for Public Health agencies in developing and developed countries. Since three ovum-and-parasite stool examinations have been demonstrated to provide sensitive results, we designed a practical and economical kit (TF-Test) that is now commercially available (Immunoassay Com. Ind. Ltda., São Paulo, Brazil). This kit allows the separate collection of three fecal specimens into a preservative solution. The specimens are then pooled, double-filtered, and concentrated by a single rapid centrifugation process. The TF-Test was evaluated in four different laboratories in a study using 1,102 outpatients and individuals living in an endemic area for enteroparasitosis. The overall sensitivity found using the TF-Test (86.2-97.8%) was significantly higher (P<0.01) than the sensitivity of conventional techniques such as the Coprotest (NL Comércio Exterior Ltda, São Paulo, Brazil) and the combination of Lutz/Hoffman, Faust, and Rugai techniques (De Carli, Diagnóstico Laboratorial das Parasitoses Humanas. Métodos e Técnicas, 1994), which ranged from 48.3% to 75.9%. When the above combined three specimen technique was repeated with three specimens collected on different days, its sensitivity became similar (P>0.01) to that of the TF-Test. The kappa index values of agreement for the TF-Test were consistent (P<0.01), being higher and ranking in a better position than conventional techniques. The high sensitivity, cost/benefit ratio, and practical aspects demonstrate that the TF-Test is suitable for individual diagnosis, epidemiological inquiries, or evaluation of chemotherapy in treated communities. PMID:15065214

  15. Experimental characterization of the ITER TF structure cooling in HELIOS test facility

    NASA Astrophysics Data System (ADS)

    Hoa, C.; Rousset, B.; Lacroix, B.; Nicollet, S.; Vallcorba, R.; Bessette, D.; Vostner, A.; Gauthier, F.

    2015-12-01

    During ITER plasma operation, large thermal loads are generated in the stainless steel Toroidal Field (TF) coil casing. To minimize the impact on the temperature of the TF Cable in Conduit Conductor (CICC), these heat loads are intercepted by case cooling channels which are implemented at the interface to the winding pack. One of the design options for the case cooling channels consists of a stainless steel pipe inserted in a rectangular groove which is machined in the casing and filled by a charged resin of high thermal conductivity. A higher number of cooling pipes is arranged at the plasma facing wall of the case, thus providing a better shielding to the TF conductor at high field. To assess the efficiency of the cooling pipes and their thermal coupling with the charged resin, experimental characterizations have been performed. First of all, the thermal resistance vs temperature of some of the individual components of a TF coil has been measured on representative samples in a cryogenic bench. Further characterizations have been performed on an integrated mock-up of the TF cooling scheme at cryogenic temperature in HELIOS test facility at CEA Grenoble. The mock-up consists of a piece of TF casing that can be heated uniformly on its surface, one cooling channel implemented in the groove which is filled with the charged resin, the filler, the ground insulation, the radial plate and one insulated CICC. The cooling pipe and the CICC are cooled by supercritical helium at 4.4 K and 5 bar; the instrumentation consists of temperature, pressure and mass flow sensors. Both stationary and transient operating modes have been investigated to assess the thermal efficiency of the case cooling design. The experimental tests are presented and the first results are discussed and analyzed in this document.

  16. The common premise for uncommon conclusions.

    PubMed

    Coady, C A J

    2013-05-01

    Recent controversy over philosophical advocacy of infanticide (or the comically-styled euphemism 'postnatal abortion') reveals a surprisingly common premise uniting many of the opponents and supporters of the practice. This is the belief that the moral status of the early fetus or embryo with respect to a right to life is identical to that of a newly born or even very young baby. From this premise, infanticidists and strong anti-abortionists draw opposite conclusions, the former that the healthy newly born have no inherent right to life and the latter that minute embryos and the very early fetus have the same right to life as young babies. (Indeed strong anti-abortionists tend to regard this right to life as identical to that possessed by adult humans.) This paper argues that these opposed conclusions are both deeply implausible and that the implausibility resides in the common premise. The argument requires some attention to the structure of the philosophical case underpinning the supposed vice of speciesism that has been given intellectual currency by many philosophers, most notably Peter Singer, and also to the reasoning behind the strong anti-abortionist adoption of the common premise. PMID:23637428

  17. Impact of several reactor features on TF coil design for TPSS

    SciTech Connect

    Miller, J.R.

    1986-01-10

    Limits of acceptable radiation levels relative to winding pack current densities in the toroidal field (TF) coils is given for relevant reactor designs. Force cooled conductors are stipulated in this study. The maximum field which can be supported while maintaining adequate stability and the ability to protect the coils in the event of a quench to end of the machine life is reported to be 6T. TF configuration, winding pack design, heat removal, stability, copper fraction and effect of damage, limiting current, and protection are discussed. 12 refs., 2 tabs. (WRF)

  18. Effect of a part span variable inlet guide vane on TF34 fan performance

    NASA Technical Reports Server (NTRS)

    Alvarez, J.; Schneider, P. W.

    1981-01-01

    Experimental aerodynamic and performance data were obtained from a TF34 engine. Part span variable inlet guide vanes mounted in front of the fan on the TF34 engine were tested to demonstrate the feasibility of modulating air flow and thrust for vertical takeoff aircraft systems. The fan was mapped to stall for a range of speeds and variable inlet guide were settings. Modulated fan tip performance and unmodulated hub performance were evaluated with a without an extended fan bypass splitter. The effect of a crosswind distortion screen on performance was also evaluated.

  19. Improvements and applications of COBRA-TF for stand-alone and coupled LWR safety analyses

    SciTech Connect

    Avramova, M.; Cuervo, D.

    2006-07-01

    The advanced thermal-hydraulic subchannel code COBRA-TF has been recently improved and applied for stand-alone and coupled LWR core calculations at the Pennsylvania State Univ. in cooperation with AREVA NP GmbH (Germany)) and the Technical Univ. of Madrid. To enable COBRA-TF for academic and industrial applications including safety margins evaluations and LWR core design analyses, the code programming, numerics, and basic models were revised and substantially improved. The code has undergone through an extensive validation, verification, and qualification program. (authors)

  20. Epistemology applied to conclusions of expert reports.

    PubMed

    Lucena-Molina, Jose-Juan

    2016-07-01

    It is believed that to build a robust reasoning logic to make probabilistic inferences in forensic science from a merely mathematical or logistical viewpoint is not enough. Mathematical logic is the positive science of reasoning and as for that it is only interested in the positive calculus of its validity, regardless any prior ontological assumption. But without a determined ontology and epistemology which imply to define the concepts that they will use, it seems difficult that the proposed scientifically correct mathematical solution be successful as a European standard for making conclusions in forensic reports because it has to be based on judicial language. Forensic experts and Courts are not interested in the development of a positive science but in a practical science: in clarifying whether certain known facts are related to a possible crime. Therefore, not only the coherence of the demonstrative logic reasoning used (logic of propositions) is important, but also the precision of the concepts used by language and consistency among them in reasoning (logic of concepts). There is a linguistic level essential for a successful communication between the forensic practitioner and the Court which is mainly related, in our opinion, to semantics and figures of speech. The first one is involved because words used in forensic conclusions often have different meanings - it is said that they are polysemic - and the second one because there is often metonymy as well. Besides, semantic differences among languages regarding words with the same etymological root add another difficulty for a better mutual understanding. The two main European judicial systems inherit a wide and deep culture related to evidence in criminal proceedings and each of them has coined their own terminology but there are other two more abstract levels such as logical and epistemological, where we can find solid arguments by which terms used at legal level on conclusions of forensic reports could be

  1. Status of GENIUS-TF-II and TF-III—The long-term stability of naked detectors in liquid nitrogen

    NASA Astrophysics Data System (ADS)

    Klapdor-Kleingrothaus, H. V.; Krivosheina, I. V.

    2006-10-01

    GENIUS-TF-II is a setup of six naked high purity Ge detectors (15 kg) in liquid nitrogen in Gran Sasso. It has been installed in October, 2004—after the first four naked Ge detectors had been installed on May 5, 2003 (GENIUS-TF-I). The GENIUS-Test-Facility (GENIUS-TF) is the first and up to now only setup ever testing the novel technique aiming at extreme background reduction in search for rare decays in particular underground. The goal of GENIUS-TF was to test some key operational parameters of the full GENIUS project proposal in 1997 [H.V. Klapdor-Kleingrothaus, Int. J. Mod. Phys. A 13 (1998) 3953; H.V. Klapdor-Kleingrothaus, J. Hellmig, M. Hirsch, GENIUS-Proposal, 20 November 1997; J. Hellmig and H.V. Klapdor-Kleingrothaus, Z. Phys. A 359 ( 1997) 351 and nucl-ex/9801004; H.V. Klapdor-Kleingrothaus, M. Hirsch, Z. Phys. A 359 (1997) 361; H.V. Klapdor-Kleingrothaus, J. Hellmig, M. Hirsch, J. Phys. G 24 (1998) 483; H.V. Klapdor-Kleingrothaus, CERN Courier, November 1997, pp. 16-18]. Simultaneous physical goal is to search for the annual modulation of the Dark Matter signal [H.V. Klapdor-Kleingrothaus, et al., Nucl. Instr. and Meth. A 481 (2002) 149; C. Tomei, A. Dietz, I. Krivosheina, H.V. Klapdor-Kleingrothaus, Nucl. Instr. and Meth. 508 (2003) 343]. After operation of GENIUS-TF over three years with finally six naked Ge detectors (15 kg) in liquid nitrogen in Gran Sasso we realize serious problems for realization of a full-size GENIUS-like experiment: (1) Background from Rn222 diffusing into the setup, on a level far beyond the expectation. (2) Limited long-term stability of naked detectors in liquid nitrogen as result of increasing leakage current. None of the six detectors is running after three years with the nominal leakage current. Three of the six detectors do not work any more at all. The results of our three years of investigation of the long-term stability may cast doubt on the possibility to perform full GENIUS-like projects.

  2. Evaluation of in vivo quantification accuracy of the Ingenuity-TF PET/MR

    SciTech Connect

    Maus, Jens Schramm, Georg; Hofheinz, Frank; Lougovski, Alexandr; Petr, Jan; Steinbach, Jörg; Oehme, Liane; Beuthien-Baumann, Bettina; Kotzerke, Jörg; Platzek, Ivan; Hoff, Jörg van den

    2015-10-15

    true” events showed no relevant deviation over time, the linearity scans revealed a systematic error of 8%–11% (avg. 9%) for the range of singles rates present in the bladder scans. After correcting for this systematic bias caused by shortcomings of the manufacturers calibration procedure, the PET to well-counter ratio increased to 0.832 ± 0.064 (0.668 –0.941), P = 1.1 ⋅ 10{sup −10}. After compensating for truncation of the upper extremities in the MR-based attenuation maps, the ratio further improved to 0.871 ± 0.069 (0.693–0.992), P = 3.9 ⋅ 10{sup −8}. Conclusions: Our results show that the Philips PET/MR underestimates activity concentrations in the bladder by 17%, which is 7 percentage points (pp.) larger than in the previously investigated PET and PET/CT systems. We attribute this increased underestimation to remaining limitations of the MR-based attenuation correction. Our results suggest that only a 2 pp. larger underestimation of activity concentrations compared to PET/CT can be observed if compensation of attenuation truncation of the upper extremities is applied. Thus, quantification accuracy of the Philips Ingenuity-TF PET/MR can be considered acceptable for clinical purposes given the ±10% error margin in the EANM guidelines. The comparison of PET images from the bladder region with urine samples has proven a useful method. It might be interesting for evaluation and comparison of the in vivo quantitative accuracy of PET, PET/CT, and especially PET/MR systems from different manufacturers or in multicenter trials.

  3. BOREAS TF-9 SSA-OBS Tower Flux, Meteorological, and Soil Temperature Data

    NASA Technical Reports Server (NTRS)

    Hall, Forrest G. (Editor); Huemmrich, Karl (Editor); Massheder, Jonathan M.; Moncrieff, John B.; Rayment, Mark B.; Jarvis, Paul G.

    2000-01-01

    The BOREAS TF-9 team collected energy, carbon dioxide, and water vapor flux data at the BOREAS SSA-OBS site during the growing season of 1994 and most of the year for 1996. From the winter of 1995 to 1996, soil temperature data were also collected and provided. The data are available in tabular ASCII files.

  4. BOREAS TF-5 SSA-OJP Tower Flux and Meteorological Data

    NASA Technical Reports Server (NTRS)

    Baldocchi, Dennis; Vogel, Christoph; Hall, Forrest G. (Editor); Huemmrich, Karl (Editor)

    2000-01-01

    The BOReal Ecosystem-Atmosphere Study Tower Flux (BOREAS TF-5) team collected tower flux data at the BOREAS Southern Study Area Old Jack Pine (SSA-OJP) site through the growing season of 1994. The data are available in tabular ASCII files.

  5. BOREAS TF-4 SSA-YJP Tower Flux, Meteorological, and Canopy Condition Data

    NASA Technical Reports Server (NTRS)

    Striegl, Robert; Wickland, Kimberly; Hall, Forrest G. (Editor); Huemmrich, Karl (Editor)

    2000-01-01

    The BOReal Ecosystem-Atmosphere Study Tower Flux (BOREAS TF-4) team collected energy, carbon dioxide, and water vapor flux data at the BOREAS Southern Study Area-Young Jack Pine (SSA-YJP) site during the growing season of 1994. In addition, meteorological data were collected both above and within the canopy. The data are available in tabular ASCII files.

  6. BOREAS TF-3 NSA-OBS Tower Flux, Meteorological, and Soil Temperature Data

    NASA Technical Reports Server (NTRS)

    Wofsy, Steven; Sutton, Doug; Goulden, Mike; Hall, Forrest G. (Editor); Huemmrich, Karl (Editor)

    2000-01-01

    The BOReal Ecosystem-Atmosphere Study Tower Flux (BOREAS TF-3) team collected tower flux, surface meteorological, and soil temperature data at the BOREAS Northern Study Area-Old Black Spruce (NSA-OBS) site continuously from the March 1994 through October 1996. The data are available in tabular ASCII files.

  7. 78 FR 39057 - Environmental Impact Statement: T.F. Green Airport, Warwick, Rhode Island

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-28

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Environmental Impact Statement: T.F. Green Airport, Warwick, Rhode Island... following locations: FAA New England, 16 New England Executive Park, Burlington MA, 781-238- 7613...

  8. Operational experience with the supercritical helium during the TF coils tests campaign of SST-1

    NASA Astrophysics Data System (ADS)

    Panchal, Rohitkumar Natvarlal; Patel, Rakesh; Tank, Jignesh; Mahesuria, Gaurang; Sonara, Dashrath; Tanna, Vipul; Patel, Jayant; Srikanth, G. L. N.; Singh, Manoj; Patel, Ketan; Christian, Dikens; Garg, Atul; Bairagi, Nitn; Gupta, Manoj Kumar; Nimavat, Hiren; Shah, Pankil; Sharma, Rajiv; Pradhan, Subrata

    2012-06-01

    Under the 'SST-1 mission mandate' recently, all the sixteen Steady State Superconducting Tokamak (SST-1) Toroidal Field (TF) magnets have been successfully tested at their nominal currents of 10000 A in cold under supercritical helium (SHe) flow conditions. The TF magnets test campaign have begun in an experimental cryostat since June 2010 with the SST-1 Helium cryogenics facility, which is a 1.3 kW at 4.5 K helium refrigerator-cum-liquefier (HRL) system. The HRL provides ~300 g-s-1supercritical helium (SHe) with cold circulator (CC) as well as ~ 60 g-s-1 without cold circulator to fulfill the forced flow cooling requirements of SST- 1 magnets. In case of single TF coil tests, we can adjust HRL process parameters such that an adequate amount of required supercritical helium is available without the cold circulator. In this paper, the complete process is describing the Process Flow Diagram (PFD) of 1.3 kW at 4.5 K HRL, techniques to generate supercritical helium without using the cold-circulator and the results of the cooldown, steady state characteristics and experience of supercritical helium operations during the TF coils test campaign have been discussed.

  9. BOREAS TF-7 SSA-OBS Tower Flux and Meteorological Data

    NASA Technical Reports Server (NTRS)

    Hall, Forrest G. (Editor); Huemmrich, Karl (Editor); Pattey, Elizabeth; Desjardins, Raymond L.

    2000-01-01

    The BOREAS TF-7 team collected meteorological data as well as energy, carbon dioxide, water vapor, methane, and nitrous oxide flux data at the BOREAS SSA-OBS site. The data were collected from 24-May to 19-Sep-1994. The data are available in tabular ASCII files.

  10. 5. Historic American Buildings Survey, T.F. Dillon, Photographer May, 1961 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Historic American Buildings Survey, T.F. Dillon, Photographer May, 1961 PHOTOCOPY OF ARCHITECT'S MEASURED DRAWING OF FRONT ELEVATION, 1875. SUBMITTED BY BRITISH GOVERNMENT TO THE CENTENNIAL DIRECTOR GENERAL FOR APPROVAL. ORIGINAL IN POSSESSION OF PHILADELPHIA DEPARTMENT OF RECORDS, ARCHIVES DIVISION. - International Exhibition of 1876, St. George's House, State's Drive, Philadelphia, Philadelphia County, PA

  11. 6. Historic American Buildings Survey, T.F. Dillon, Photographer May, 1961 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Historic American Buildings Survey, T.F. Dillon, Photographer May, 1961 PHOTOCOPY OF ARCHITECT'S GROUND FLOOR PLAN, 1875. SUBMITTED BY BRITISH GOVERNMENT TO THE CENTENNIAL DIRECTOR GENERAL FOR APPROVAL. ORIGINAL IN POSSESSION OF PHILADELPHIA DEPARTMENT OF RECORDS, ARCHIVES DIVISION. - International Exhibition of 1876, St. George's House, State's Drive, Philadelphia, Philadelphia County, PA

  12. BOREAS TF-1 SSA-OA Tower Flux, Meteorological, and Soil Temperature Data

    NASA Technical Reports Server (NTRS)

    Hall, Forrest G. (Editor); Huemmrich, Karl (Editor); Black, T. Andrew; Chen, Z.; Nesic, Zoran

    2000-01-01

    The BOREAS TF-1 team collected energy, carbon dioxide, and momentum flux data above the canopy along with meteorological and soils data at the BOREAS SSA-OA site from mid-April to the end of the year for 1996. The data are available in tabular ASCII files.

  13. BOREAS TF-1 SSA-OA Understory Flux, Meteorological, and Soil Temperature Data

    NASA Technical Reports Server (NTRS)

    Hall, Forrest G. (Editor); Huemmrich, Karl (Editor); Black, T. Andrew; Chen, Z.; Nesic, Zoran

    2000-01-01

    The BOREAS TF-1 team collected energy, carbon dioxide, and momentum flux data under the canopy along with meteorological and soils data at the BOREAS SSA-OA site from mid-October to mid-November of 1993 and throughout all of 1994. The data are available in tabular ASCII files.

  14. BOREAS TF-6 SSA-YA Surface Energy Flux and Meteorological Data

    NASA Technical Reports Server (NTRS)

    Bessemoulin, Pierre; Puech, Dominique; Hall, Forrest G. (Editor); Huemmrich, Karl (Editor)

    2000-01-01

    The BOREAS TF-6 team collected surface energy flux and meteorology data at the SSA-YA site. The data characterize the energy flux and meteorological conditions at the site from 18-Jul to 20-Sep-1994. The data set does not contain any trace gas exchange measurements. The data are available in tabular ASCII files.

  15. BOREAS TF-8 NSA-OJP Tower Flux, Meteorological, and Soil Temperature Data

    NASA Technical Reports Server (NTRS)

    Hall, Forrest G. (Editor); Huemmrich, Karl (Editor); Moore, Kathleen E.; Fitzjarrald, David R.

    2000-01-01

    The BOREAS TF-8 team collected energy, CO2, and water vapor flux data at the BOREAS NSA-OJP site during the growing season of 1994 and most of the year for 1996. The data are available in tabular ASCII files.

  16. A Novel Demountable TF Joint Design for Low Aspect Ratio Spherical Torus Tokamaks

    SciTech Connect

    R.D. Woolley

    2009-05-29

    A novel shaped design for the radial conductors and demountable electrical joints connecting inner and outer legs of copper TF system conductors in low aspect ratio tokamaks is described and analysis results are presented. Specially shaped designs can optimize profiles of electrical current density, magnetic force, heating, and mechanical stress.

  17. A Novel Demountable TF Joint Design for Low Aspect Ratio Spherical Torus Tokamaks

    SciTech Connect

    Robert D. Woolley

    2009-06-11

    A novel shaped design for the radial conductors and demountable electrical joints connecting inner and outer legs of copper TF system conductors in low aspect ratio tokamaks is described and analysis results are presented. Specially shaped designs can optimize profiles of electrical current density, magnetic force, heating, and mechanical stress.

  18. The Apollo SWC Experiment: Results, Conclusions, Consequences

    NASA Astrophysics Data System (ADS)

    Geiss, J.; Bühler, F.; Cerutti, H.; Eberhardt, P.; Filleux, Ch.; Meister, J.; Signer, P.

    2004-01-01

    interplanetary space at the time of the five foil exposures. Finally, we discuss, from today's perspective, some of the implications and conclusions that can be drawn from the SWC results, concerning the Sun and its history, the solar system, the galaxy and the universe.

  19. 77 FR 73114 - Draft Written Re-Evaluation for Environmental Impact Statement: T.F. Green Airport, Warwick, RI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-07

    ... Federal Aviation Administration Draft Written Re-Evaluation for Environmental Impact Statement: T.F. Green... to T.F. Green Draft Written Re-Evaluation'' in the subject line Mail: Richard Doucette, Environmental... England, 16 New England Executive Park, Burlington, MA, 781- 238-7613; Warwick Central Library, 600...

  20. Mutation in Torenia fournieri Lind. UFO homolog confers loss of TfLFY interaction and results in a petal to sepal transformation.

    PubMed

    Sasaki, Katsutomo; Yamaguchi, Hiroyasu; Aida, Ryutaro; Shikata, Masahito; Abe, Tomoko; Ohtsubo, Norihiro

    2012-09-01

    We identified a Torenia fournieri Lind. mutant (no. 252) that exhibited a sepaloid phenotype in which the second whorls were changed to sepal-like organs. This mutant had no stamens, and the floral organs consisted of sepals and carpels. Although the expression of a torenia class B MADS-box gene, GLOBOSA (TfGLO), was abolished in the 252 mutant, no mutation of TfGLO was found. Among torenia homologs such as APETALA1 (AP1), LEAFY (LFY), and UNUSUAL FLORAL ORGANS (UFO), which regulate expression of class B genes in Arabidopsis, only accumulation of the TfUFO transcript was diminished in the 252 mutant. Furthermore, a missense mutation was found in the coding region of the mutant TfUFO. Intact TfUFO complemented the mutant phenotype whereas mutated TfUFO did not; in addition, the transgenic phenotype of TfUFO-knockdown torenias coincided with the mutant phenotype. Yeast two-hybrid analysis revealed that the mutated TfUFO lost its ability to interact with TfLFY protein. In situ hybridization analysis indicated that the transcripts of TfUFO and TfLFY were partially accumulated in the same region. These results clearly demonstrate that the defect in TfUFO caused the sepaloid phenotype in the 252 mutant due to the loss of interaction with TfLFY. PMID:22577962

  1. Research on aviation unsafe incidents classification with improved TF-IDF algorithm

    NASA Astrophysics Data System (ADS)

    Wang, Yanhua; Zhang, Zhiyuan; Huo, Weigang

    2016-05-01

    The text content of Aviation Safety Confidential Reports contains a large number of valuable information. Term frequency-inverse document frequency algorithm is commonly used in text analysis, but it does not take into account the sequential relationship of the words in the text and its role in semantic expression. According to the seven category labels of civil aviation unsafe incidents, aiming at solving the problems of TF-IDF algorithm, this paper improved TF-IDF algorithm based on co-occurrence network; established feature words extraction and words sequential relations for classified incidents. Aviation domain lexicon was used to improve the accuracy rate of classification. Feature words network model was designed for multi-documents unsafe incidents classification, and it was used in the experiment. Finally, the classification accuracy of improved algorithm was verified by the experiments.

  2. BOREAS TF-11 CO2 and CH4 Flux Data from the SSA-Fen

    NASA Technical Reports Server (NTRS)

    Valentine, David W.; Hall, Forrest G. (Editor); Conrad, Sara (Editor)

    2000-01-01

    The BOREAS TF-11 team collected several data sets in its efforts to fully describe the flux and site characteristics at the SSA-Fen site. This data set contains fluxes of methane and carbon dioxide at the SSA-Fen site measured using static chambers. The measurements were conducted as part of a 2 x 2 factorial experiment in which we added carbon (300 g/sq m as wheat straw) and nitrogen (6 g/sq m as urea) to four replicate locations in the vicinity of the TF-11 tower. In addition to siting and treatment variables, it reports air temperature and water table height relative to the average peat surface during each measurement. The data set covers the period from the first week of June 1994 through the second week of September 1994. The data are stored in tabular ASCII files.

  3. BOREAS TF-11 CO2 and CH4 Concentration Data from the SSA-Fen

    NASA Technical Reports Server (NTRS)

    Hall, Forrest G. (Editor); Conrad, Sara (Editor); Valentine, David W.

    2000-01-01

    The BOREAS TF-11 team collected several data sets in its efforts to fully describe the flux and site characteristics at the SSA-Fen site. This data set contains temperature, pH, and concentration profiles of methane and carbon dioxide within the surface 50 cm of peat. The measurements were conducted as part of a 2 x 2 factorial experiment in which we added carbon (300 g/sq m as wheat straw) and nitro-gen (6 g/sq m as urea) to four replicate locations in the vicinity of the TF-11 tower. The data set covers the period from the first week of June 1994 through the second week of September 1994. The data are stored in tabular ASCII files.

  4. Test Results of the First US ITER TF Conductor in SULTAN

    SciTech Connect

    Martovetsky, N N; Hatfield, D R; Miller, J R; Gung, C; Schultz, J S; Cheggour, N; Goodrich, L F; Bruzzone, P; Stepanov, B; Wesche, R; Seeber, B

    2008-08-18

    The US Domestic Agency is one of six parties supplying TF cable-in-conduit conductors (CICCs) for ITER. Previous tests have shown that measured performance of the TF CICCs can be much lower than expected from the strand properties at the projected uniaxial strain and that the cabling pattern may also be an important factor. Worst of all, voltage signals well below the expected critical surface could not be reliably interpreted or canceled, making test results very suspect. The TFUS1 sample was prepared to achieve multiple goals: (1) to ensure uniform current distribution and to eliminate parasitic voltage signals by improving joints, (2) to explore the potential benefits of a different cabling pattern for better support of strain-sensitive strands, and (3) to explore the source of voltage development in the cable through the use of innovative penetrating diagnostics. Test results of the first US-made samples are presented and discussed.

  5. BOREAS TF-11 SSA-Fen 1996 Water Surface Film Capping Data

    NASA Technical Reports Server (NTRS)

    Billesbach, David P.; Hall, Forrest G. (Editor); Knapp, David E. (Editor)

    2000-01-01

    The BOREAS TF-11 team gathered a variety of data to complement its tower flux measurements collected at the SSA-Fen site. The data described in this document were made by the TF-11 team at the SSA-Fen site to quantify the effect that the films observed to form on open water surfaces had on the transfer of carbon dioxide and methane from the water to the air. Measurements of fluxes of carbon dioxide and methane were made in 1994 and in 1996 using the chamber flux method. A gas chromatograph and a LI-COR LI-6200 were used to measure concentrations and to calculate the fluxes. The data are stored in tabular ASCII files.

  6. From data repositories to submission portals: rethinking the role of domain-specific databases in CollecTF.

    PubMed

    Kılıç, Sefa; Sagitova, Dinara M; Wolfish, Shoshannah; Bely, Benoit; Courtot, Mélanie; Ciufo, Stacy; Tatusova, Tatiana; O'Donovan, Claire; Chibucos, Marcus C; Martin, Maria J; Erill, Ivan

    2016-01-01

    Domain-specific databases are essential resources for the biomedical community, leveraging expert knowledge to curate published literature and provide access to referenced data and knowledge. The limited scope of these databases, however, poses important challenges on their infrastructure, visibility, funding and usefulness to the broader scientific community. CollecTF is a community-oriented database documenting experimentally validated transcription factor (TF)-binding sites in the Bacteria domain. In its quest to become a community resource for the annotation of transcriptional regulatory elements in bacterial genomes, CollecTF aims to move away from the conventional data-repository paradigm of domain-specific databases. Through the adoption of well-established ontologies, identifiers and collaborations, CollecTF has progressively become also a portal for the annotation and submission of information on transcriptional regulatory elements to major biological sequence resources (RefSeq, UniProtKB and the Gene Ontology Consortium). This fundamental change in database conception capitalizes on the domain-specific knowledge of contributing communities to provide high-quality annotations, while leveraging the availability of stable information hubs to promote long-term access and provide high-visibility to the data. As a submission portal, CollecTF generates TF-binding site information through direct annotation of RefSeq genome records, definition of TF-based regulatory networks in UniProtKB entries and submission of functional annotations to the Gene Ontology. As a database, CollecTF provides enhanced search and browsing, targeted data exports, binding motif analysis tools and integration with motif discovery and search platforms. This innovative approach will allow CollecTF to focus its limited resources on the generation of high-quality information and the provision of specialized access to the data.Database URL: http://www.collectf.org/. PMID:27114493

  7. From data repositories to submission portals: rethinking the role of domain-specific databases in CollecTF

    PubMed Central

    Kılıç, Sefa; Sagitova, Dinara M.; Wolfish, Shoshannah; Bely, Benoit; Courtot, Mélanie; Ciufo, Stacy; Tatusova, Tatiana; O’Donovan, Claire; Chibucos, Marcus C.; Martin, Maria J.; Erill, Ivan

    2016-01-01

    Domain-specific databases are essential resources for the biomedical community, leveraging expert knowledge to curate published literature and provide access to referenced data and knowledge. The limited scope of these databases, however, poses important challenges on their infrastructure, visibility, funding and usefulness to the broader scientific community. CollecTF is a community-oriented database documenting experimentally validated transcription factor (TF)-binding sites in the Bacteria domain. In its quest to become a community resource for the annotation of transcriptional regulatory elements in bacterial genomes, CollecTF aims to move away from the conventional data-repository paradigm of domain-specific databases. Through the adoption of well-established ontologies, identifiers and collaborations, CollecTF has progressively become also a portal for the annotation and submission of information on transcriptional regulatory elements to major biological sequence resources (RefSeq, UniProtKB and the Gene Ontology Consortium). This fundamental change in database conception capitalizes on the domain-specific knowledge of contributing communities to provide high-quality annotations, while leveraging the availability of stable information hubs to promote long-term access and provide high-visibility to the data. As a submission portal, CollecTF generates TF-binding site information through direct annotation of RefSeq genome records, definition of TF-based regulatory networks in UniProtKB entries and submission of functional annotations to the Gene Ontology. As a database, CollecTF provides enhanced search and browsing, targeted data exports, binding motif analysis tools and integration with motif discovery and search platforms. This innovative approach will allow CollecTF to focus its limited resources on the generation of high-quality information and the provision of specialized access to the data. Database URL: http://www.collectf.org/ PMID:27114493

  8. BOREAS TF-11 SSA-Fen Soil Surface CO2 Flux Data

    NASA Technical Reports Server (NTRS)

    Arkebauer, Timothy J.; Hall, Forrest G. (Editor); Knapp, David E. (Editor)

    2000-01-01

    The BOREAS TF-11 team gathered a variety of data to complement its tower flux measurements collected at the SSA-Fen site. These data are soil surface CO 2 flux data at the SSA-Fen site from 27- May-1994 to 23-Sep-1994 and from 13-May-1995 to 03-Oct-1995. A portable gas exchange system was used to make these measurements. The data are stored in tabular ASCII files.

  9. BOREAS TF-4 CO2 and CH4 Chamber Flux Data from the SSA

    NASA Technical Reports Server (NTRS)

    Anderson, Dean; Striegl, Robert; Wickland, Kimberly; Hall, Forrest G. (Editor); Conrad, Sara (Editor)

    2000-01-01

    The BOREAS TF-4 team measured fluxes of CO2 and CH4 across the soil-air interface in four ages of jack pine forest at the BOREAS SSA during August 1993 to March 1995. Gross and net flux of CO2 and flux of CH4 between soil and air are presented for 24 chamber sites in mature jack pine forest, 20-year-old, 4-year-old, and clear cut areas. The data are stored in tabular ASCII files.

  10. Two-phase interfacial area and flow regime modeling in FLOWTRAN-TF code

    SciTech Connect

    Smith, F.G. III; Lee, S.Y.; Flach, G.P.; Hamm, L.L.

    1992-01-01

    FLOWTRAN-TF is a new two-component, two-phase thermal-hydraulics code to capture the detailed assembly behavior associated with loss-of-coolant accident analyses in multichannel assemblies of the SRS reactors. The local interfacial area of the two-phase mixture is computed by summing the interfacial areas contributed by each of three flow regimes. For smooth flow regime transitions, the code uses an interpolation technique in terms of component void fraction for each basic flow regime.

  11. Two-phase interfacial area and flow regime modeling in FLOWTRAN-TF code

    SciTech Connect

    Smith, F.G. III; Lee, S.Y.; Flach, G.P.; Hamm, L.L.

    1992-12-31

    FLOWTRAN-TF is a new two-component, two-phase thermal-hydraulics code to capture the detailed assembly behavior associated with loss-of-coolant accident analyses in multichannel assemblies of the SRS reactors. The local interfacial area of the two-phase mixture is computed by summing the interfacial areas contributed by each of three flow regimes. For smooth flow regime transitions, the code uses an interpolation technique in terms of component void fraction for each basic flow regime.

  12. BOREAS TF-2 SSA-OA Tethersonde Meteorological and Ozone Data

    NASA Technical Reports Server (NTRS)

    Arnold, A. James; Mickle, Robert E.; Hall, Forrest G. (Editor); Huemmrich, Karl (Editor)

    2000-01-01

    The BOReal Ecosystem-Atmosphere Study Tower Flux-2 (BOREAS TF-2) team collected meteorological and ozone measurements from instruments mounted below a tethered balloon. These data were collected at the Southern Study Area Old Aspen (SSA-OA) site to extend meteorological and ozone measurements made from the flux tower to heights of 300 m. The tethersonde operated during the fall of 1993 and the spring, summer, and fall of 1994. The data are available in tabular ASCII files.

  13. BOREAS TF-1 SSA-OA Weekly Tower CH4 and N2O Flux

    NASA Technical Reports Server (NTRS)

    Thurtell, George; Edwards, Grant; Simpson, George; Hall, Forrest G. (Editor); Huemmrich, Karl (Editor)

    2000-01-01

    The BOREAS TF-1 team collected various trace gas and energy flux data in its efforts to characterize the temporal energy and gas exchanges that occurred over the SSA-OA site. This data set contains methane (CH4) and nitrous oxide (N2O) fluxes that were measured at the BOREAS SSA-OA site. These fluxes were measured from 16-Apr to 16-Sep-1994. The data were averaged to weekly values and are available in tabular ASCII files.

  14. Qualification of the US made conductors for ITER TF magnet system

    SciTech Connect

    Martovetsky, N; Hatfield, D; Miller, J; Bruzzone, P; Stepanov, B; Seber, B

    2009-10-08

    The US Domestic Agency (USDA) is one of the six suppliers of the TF conductor for ITER. In order to qualify conductors according to ITER requirements we prepared several lengths of the CICC and short samples for testing in the SULTAN facility in CRPP, Switzerland. We also fully characterized the strands that were used in these SULTAN samples. Fabrication experience and test results are presented and discussed.

  15. Qualification of the US Made Conductors for ITER TF Magnet System

    SciTech Connect

    Martovetsky, Nicolai N; Hatfield, Daniel R; Miller, John R; Bruzzone, P.; Stepanov, B.; Seber, B.

    2010-01-01

    The US Domestic Agency (USDA) is one of the six suppliers of the TF conductor for ITER. In order to qualify conductors according to ITER requirements we prepared several lengths of the CICC and short samples for testing in the SULTAN facility in CRPP, Switzerland. We also fully characterized the strands that were used in these SULTAN samples. Fabrication experience and test results are presented and discussed.

  16. Design considerations for the TF center conductor post for the Ignition Spherical Torus (IST)

    SciTech Connect

    Dalton, G.R.; Haines, J.R.

    1986-01-01

    A trade-off study has been carried out to compare the differential costs of using high-strength alloy copper versus oxygen-free, high-conductivity (OFHC) copper for the center legs of the toroidal field (TF) coils of an Ignition Spherical Torus (IST). The electrical heating, temperatures, stresses, cooling requirements, material costs, pump costs, and power to drive the TF coils and pumps are all assessed for both materials for a range of compact tokamak reactors. The alloy copper material is found to result in a more compact reactor and to allow use of current densities of up to 170 MA/mS versus 40 MA/mS for the OFHC copper. The OFHC conductor system with high current density is $24 million less expensive than more conventional copper systems with 30 MA/mS. The alloy copper system costs $32 million less than conventional systems. Therefore, the alloy system offers a net savings of $8 million compared to the 50% cold-worked OFHC copper system. Although the savings are a significant fraction of the center conductor post cost, they are relatively insignificant in terms of the total device cost. It is concluded that the use of alloy copper contributes very little to the economic or technical viability of the compact IST. It is recommended that a similar systematic approach be applied to evaluating coil material and current density trade-offs for other compact copper-TF-coil tokamak designs. 9 refs., 13 figs., 13 tabs.

  17. Tf-lipoplex-mediated c-Jun silencing improves neuronal survival following excitotoxic damage in vivo.

    PubMed

    Cardoso, A L C; Costa, P; de Almeida, L P; Simões, S; Plesnila, N; Culmsee, C; Wagner, E; de Lima, M C Pedroso

    2010-03-19

    Excitotoxicity is one of the main features responsible for neuronal cell death after acute brain injury and in several neurodegenerative disorders, for which only few therapeutic options are currently available. In this work, RNA interference was employed to identify and validate a potential target for successful treatment of excitotoxic brain injury, the transcription factor c-Jun. The nuclear translocation of c-Jun and its upregulation are early events following glutamate-induced excitotoxic damage in primary neuronal cultures. We present evidence for the efficient knockdown of this transcription factor using a non-viral vector consisting of cationic liposomes associated to transferrin (Tf-lipoplexes). Tf-lipoplexes were able to deliver anti-c-Jun siRNAs to neuronal cells in culture, resulting in efficient silencing of c-Jun mRNA and protein and in a significant decrease of cell death following glutamate-induced damage or oxygen-glucose deprivation. This formulation also leads to a significant c-Jun knockdown in the mouse hippocampus in vivo, resulting in the attenuation of both neuronal death and inflammation following kainic acid-mediated lesion of this region. Furthermore, a strong reduction of seizure activity and cytokine production was observed in animals treated with anti-c-Jun siRNAs. These findings demonstrate the efficient delivery of therapeutic siRNAs to the brain by Tf-lipoplexes and validate c-Jun as a promising therapeutic target in neurodegenerative disorders involving excitotoxic lesions. PMID:19913061

  18. Sp8 and COUP-TF1 Reciprocally Regulate Patterning and Fgf Signaling in Cortical Progenitors

    PubMed Central

    Borello, Ugo; Madhavan, Mayur; Vilinsky, Ilya; Faedo, Andrea; Pierani, Alessandra; Rubenstein, John; Campbell, Kenneth

    2014-01-01

    To gain new insights into the transcriptional regulation of cortical development, we examined the role of the transcription factor Sp8, which is downstream of Fgf8 signaling and known to promote rostral cortical development. We have used a binary transgenic system to express Sp8 throughout the mouse telencephalon in a temporally restricted manner. Our results show that misexpression of Sp8 throughout the telencephalon, at early but not late embryonic stages, results in cortical hypoplasia, which is accompanied by increased cell death, reduced proliferation, and precocious neuronal differentiation. Misexpression of Sp8 at early developmental stages represses COUP-TF1 expression, a negative effector of Fgf signaling and a key promoter of posterior cortical identity, while ablation of Sp8 has the opposite effect. In addition, transgenic misexpression of COUP-TF1 resulted in downregulation of Sp8, indicating a reciprocal cross-regulation between these 2 transcription factors. Although Sp8 has been suggested to induce and/or maintain Fgf8 expression in the embryonic telencephalon, neither Fgf8 nor Fgf15 was upregulated using our gain-of-function approach. However, misexpression of Sp8 greatly increased the expression of Fgf target molecules, suggesting enhanced Fgf signaling. Thus, we propose that Sp8 promotes rostral and dorsomedial cortical development by repressing COUP-TF1 and promoting Fgf signaling in pallial progenitors. PMID:23307639

  19. Sp8 and COUP-TF1 reciprocally regulate patterning and Fgf signaling in cortical progenitors.

    PubMed

    Borello, Ugo; Madhavan, Mayur; Vilinsky, Ilya; Faedo, Andrea; Pierani, Alessandra; Rubenstein, John; Campbell, Kenneth

    2014-06-01

    To gain new insights into the transcriptional regulation of cortical development, we examined the role of the transcription factor Sp8, which is downstream of Fgf8 signaling and known to promote rostral cortical development. We have used a binary transgenic system to express Sp8 throughout the mouse telencephalon in a temporally restricted manner. Our results show that misexpression of Sp8 throughout the telencephalon, at early but not late embryonic stages, results in cortical hypoplasia, which is accompanied by increased cell death, reduced proliferation, and precocious neuronal differentiation. Misexpression of Sp8 at early developmental stages represses COUP-TF1 expression, a negative effector of Fgf signaling and a key promoter of posterior cortical identity, while ablation of Sp8 has the opposite effect. In addition, transgenic misexpression of COUP-TF1 resulted in downregulation of Sp8, indicating a reciprocal cross-regulation between these 2 transcription factors. Although Sp8 has been suggested to induce and/or maintain Fgf8 expression in the embryonic telencephalon, neither Fgf8 nor Fgf15 was upregulated using our gain-of-function approach. However, misexpression of Sp8 greatly increased the expression of Fgf target molecules, suggesting enhanced Fgf signaling. Thus, we propose that Sp8 promotes rostral and dorsomedial cortical development by repressing COUP-TF1 and promoting Fgf signaling in pallial progenitors. PMID:23307639

  20. Exploring lateral genetic transfer among microbial genomes using TF-IDF

    PubMed Central

    Cong, Yingnan; Chan, Yao-ban; Ragan, Mark A.

    2016-01-01

    Many microbes can acquire genetic material from their environment and incorporate it into their genome, a process known as lateral genetic transfer (LGT). Computational approaches have been developed to detect genomic regions of lateral origin, but typically lack sensitivity, ability to distinguish donor from recipient, and scalability to very large datasets. To address these issues we have introduced an alignment-free method based on ideas from document analysis, term frequency-inverse document frequency (TF-IDF). Here we examine the performance of TF-IDF on three empirical datasets: 27 genomes of Escherichia coli and Shigella, 110 genomes of enteric bacteria, and 143 genomes across 12 bacterial and three archaeal phyla. We investigate the effect of k-mer size, gap size and delineation of groups on the inference of genomic regions of lateral origin, finding an interplay among these parameters and sequence divergence. Because TF-IDF identifies donor groups and delineates regions of lateral origin within recipient genomes, aggregating these regions by gene enables us to explore, for the first time, the mosaic nature of lateral genes including the multiplicity of biological sources, ancestry of transfer and over-writing by subsequent transfers. We carry out Gene Ontology enrichment tests to investigate which biological processes are potentially affected by LGT. PMID:27452976

  1. Water-tunnel study results of a TF/A-18 and F/A-18 canopy flow visualization

    NASA Technical Reports Server (NTRS)

    Johnson, Steven A.; Fisher, David F.

    1990-01-01

    A water tunnel study examining the influence of canopy shape on canopy and leading edge extension flow patterns was initiated. The F/A-18 single-place canopy model and the TF/A-18 two place canopy model were the study subjects. Plan view and side view photographs showing the flow patterns created by injected colored dye are presented for 0 deg and 5 deg sideslip angles. Photographs taken at angle of attack and sideslip conditions correspond to test departure points found in flight test. Flight experience has shown that the TF/A-18 airplane departs in regions where the F/A-18 airplane is departure-resistant. The study results provide insight into the differences in flow patterns which may influence the resulting aerodynamics of the TF/A-18 and F/A-18 aircraft. It was found that at 0 deg sideslip, the TF/A-18 model has more downward flow on the sides of the canopy than the F/A-18 model. This could be indicative of flow from the leading edge extension (LEX) vortexes impinging on the sides of the wider TF/A-18 canopy. In addition, the TF/A-18 model has larger areas of asymmetric separated and unsteady flow on the LEXs and fuselage, possibly indicating a lateral and directional destabilizing effect at the conditions studied.

  2. Engineering, Manufacture and Preliminary Testing of the ITER Toroidal Field (TF) Magnet Helium Cold Circulator

    NASA Astrophysics Data System (ADS)

    Rista, P. E. C.; Shull, J.; Sargent, S.

    2015-12-01

    The ITER cryodistribution system provides the supercritical Helium (SHe) forced flow cooling to the magnet system using cold circulators. The cold circulators are located in each of five separate auxiliary cold boxes planned for use in the facility. Barber-Nichols Inc. has been awarded a contract from ITER-India for engineering, manufacture and testing of the Toroidal Field (TF) Magnet Helium Cold Circulator. The cold circulator will be extensively tested at Barber-Nichols’ facility prior to delivery for qualification testing at the Japan Atomic Energy Agency's (JAEA) test facility at Naka, Japan. The TF Cold Circulator integrates features and technical requirements which Barber-Nichols has utilized when supplying helium cold circulators worldwide over a period of 35 years. Features include a vacuum-jacketed hermetically sealed design with a very low helium leak rate, a heat shield for use with both nitrogen & helium cold sources, a broad operating range with a guaranteed isentropic efficiency over 70%, and impeller design features for high efficiency. The cold circulator will be designed to meet MTBM of 17,500 hours and MTBF of 36,000 hours. Vibration and speed monitoring are integrated into a compact package on the rotating assembly with operation and health monitoring in a multi-drop PROFIBUS communication environment using an electrical cabinet with critical features and full local and network PLC interface and control. For the testing in Japan and eventual installation in Europe, the cold circulator must be certified to the Japanese High Pressure Gas Safety Act (JHPGSA) and CE marked in compliance with the European Pressure Equipment Directive (PED) including Essential Safety Requirements (ESR). The test methodology utilized at Barber-Nichols’ facility and the resulting test data, validating the high efficiency of the TF Cold Circulator across a broad operating range, are important features of this paper.

  3. CardioTF, a database of deconstructing transcriptional circuits in the heart system

    PubMed Central

    2016-01-01

    Background: Information on cardiovascular gene transcription is fragmented and far behind the present requirements of the systems biology field. To create a comprehensive source of data for cardiovascular gene regulation and to facilitate a deeper understanding of genomic data, the CardioTF database was constructed. The purpose of this database is to collate information on cardiovascular transcription factors (TFs), position weight matrices (PWMs), and enhancer sequences discovered using the ChIP-seq method. Methods: The Naïve-Bayes algorithm was used to classify literature and identify all PubMed abstracts on cardiovascular development. The natural language learning tool GNAT was then used to identify corresponding gene names embedded within these abstracts. Local Perl scripts were used to integrate and dump data from public databases into the MariaDB management system (MySQL). In-house R scripts were written to analyze and visualize the results. Results: Known cardiovascular TFs from humans and human homologs from fly, Ciona, zebrafish, frog, chicken, and mouse were identified and deposited in the database. PWMs from Jaspar, hPDI, and UniPROBE databases were deposited in the database and can be retrieved using their corresponding TF names. Gene enhancer regions from various sources of ChIP-seq data were deposited into the database and were able to be visualized by graphical output. Besides biocuration, mouse homologs of the 81 core cardiac TFs were selected using a Naïve-Bayes approach and then by intersecting four independent data sources: RNA profiling, expert annotation, PubMed abstracts and phenotype. Discussion: The CardioTF database can be used as a portal to construct transcriptional network of cardiac development. Availability and Implementation: Database URL: http://www.cardiosignal.org/database/cardiotf.html.

  4. Unusual redox stability of neptunium in the ionic liquid [Hbet][Tf(2)N].

    PubMed

    Long, Kristy; Goff, George; Runde, Wolfgang

    2014-07-25

    The behavior of neptunium in the ionic liquid betaine bistriflimide, [Hbet][Tf2N], has been studied spectroscopically at room temperature and 60 °C for the first time. An unprecedented complex redox chemistry is observed, with up to three oxidation states (iv, v and vi) and up to six Np species existing simultaneously. Both redox reactions and coordination of betaine are observed for Np(iv), (v) and (vi). Elevating the temperature accelerates the coordination of Np(v) with betaine and reduction reactions slow down. PMID:24752760

  5. Development of dynamic simulation of TF34-GE-100 turbofan engine with post-stall capability

    NASA Technical Reports Server (NTRS)

    Krosel, S. M.

    1984-01-01

    This paper describes the development of a hybrid computer simulation of a TF34-GE-100 turbofan engine with post-stall capability. The simulation operates in real-time and will be used to test and evaluate stall recovery control modes for this engine. The simulation calculations are performed by an analog computer with a peripheral multivariable function generation unit used for computing bivariate functions. Tabular listings of simulation variables are obtained by interfacing to a digital computer and using a custom software package for data collection and display.

  6. Development of dynamic simulation of TF34-GE-100 turbofan engine with post-stall capability

    NASA Technical Reports Server (NTRS)

    Krosel, S. M.

    1984-01-01

    This paper describes the development of a hybrid computer simulation of a TF34-GE-100 turbofan engine with post-stall capability. The simulation operates in real-time and will be used to test and evaluate stall recovery control modes for this engine. The simulation calculations are performed by an analog computer with a peripheral multivariable function generation unit used for computing bivariate functions. Tabular listings of a simulation variables are obtained by interfacing to a digital computer and using a custom software package for data collection and display.

  7. Every Site Counts: Submitting Transcription Factor-Binding Site Information through the CollecTF Portal.

    PubMed

    Erill, Ivan

    2015-08-01

    Experimentally verified transcription factor-binding sites represent an information-rich and highly applicable data type that aptly summarizes the results of time-consuming experiments and inference processes. Currently, there is no centralized repository for this type of data, which is routinely embedded in articles and extremely hard to mine. CollecTF provides the first standardized resource for submission and deposition of these data into the NCBI RefSeq database, maximizing its accessibility and prompting the community to adopt direct submission policies. PMID:26013488

  8. A parallelization approach to the COBRA-TF thermal-hydraulic subchannel code

    NASA Astrophysics Data System (ADS)

    Ramos, Enrique; Abarca, Agustín; Roman, Jose E.; Miró, Rafael

    2014-06-01

    In order to reduce the response time when simulating large reactors in detail, we have developed a parallel version of the thermal-hydraulic subchannel code COBRA-TF, with standard message passing technology (MPI). The parallelization is oriented to reactor cells, so it is best suited for models consisting of many cells. The generation of the Jacobian is parallelized, in such a way that each processor is in charge of generating the data associated to a subset of cells. Also, the solution of the linear system of equations is done in parallel, using the PETSc toolkit.

  9. BOREAS TF-8 NSA-OJP and SSA-OBS Ceilometer Data

    NASA Technical Reports Server (NTRS)

    Moore, Kathleen E.; Hall, Forrest G. (Editor); Huemmrich, Karl (Editor); Fitzjarrald, David R.

    2000-01-01

    The BOREAS TF-8 team used ceilometers to collect data on the fraction of the sky covered with clouds and the cloud height. Included with these data is the surface-based lifting condensation level, derived from temperature and humidity values acquired at the flux tower at the NSA-OJP site. Ceilo-meter data were collected at the NSA-OJP site in 1994 and at the NSA-OJP and SSA-OBS sites in 1996. The data are available in tabular ASCII files. The data files are available on a CD-ROM (see document number 20010000884).

  10. Modeling and analysis of the TF30-P-3 compressor system with inlet pressure distortion

    NASA Technical Reports Server (NTRS)

    Mazzawy, R. S.; Banks, G. A.

    1976-01-01

    Circumferential inlet distortion testing of a TF30-P-3 afterburning turbofan engine was conducted at NASA-Lewis Research Center. Pratt and Whitney Aircraft analyzed the data using its multiple segment parallel compressor model and classical compressor theory. Distortion attenuation analysis resulted in a detailed flow field calculation with good agreement between multiple segment model predictions and the test data. Sensitivity of the engine stall line to circumferential inlet distortion was calculated on the basis of parallel compressor theory to be more severe than indicated by the data. However, the calculated stall site location was in agreement with high response instrumentation measurements.

  11. Circumferential distortion modeling of the TF30-P-3 compression system

    NASA Technical Reports Server (NTRS)

    Mazzawy, R. S.; Banks, G. A.

    1977-01-01

    Circumferential inlet pressure and temperature distortion testing of the TF30 P-3 turbofan engine was conducted. The compressor system at the test conditions run was modelled according to a multiple segment parallel compressor model. Aspects of engine operation and distortion configuration modelled include the effects of compressor bleeds, relative pressure-temperature distortion alignment and circumferential distortion extent. Model predictions for limiting distortion amplitudes and flow distributions within the compression system were compared with test results in order to evaluate predicted trends. Relatively good agreement was obtained. The model also identified the low pressure compressor as the stall-initiating component, which was in agreement with the data.

  12. Design and performance evaluation of a whole-body Ingenuity TF PET–MRI system

    PubMed Central

    Zaidi, H; Ojha, N; Morich, M; Griesmer, J; Hu, Z; Maniawski, P; Ratib, O; Izquierdo-Garcia, D; Fayad, Z A; Shao, L

    2014-01-01

    The Ingenuity TF PET–MRI is a newly released whole-body hybrid PET–MR imaging system with a Philips time-of-flight GEMINI TF PET and Achieva 3T X-series MRI system. Compared to PET–CT, modifications to the positron emission tomography (PET) gantry were made to avoid mutual system interference and deliver uncompromising performance which is equivalent to the standalone systems. The PET gantry was redesigned to introduce magnetic shielding for the photomultiplier tubes (PMTs). Stringent electromagnetic noise requirements of the MR system necessitated the removal of PET gantry electronics to be housed in the PET–MR equipment room. We report the standard NEMA measurements for the PET scanner. PET imaging and performance measurements were done at Geneva University Hospital as described in the NEMA Standards NU2-2007 manual. The scatter fraction (SF) and noise equivalent count rate (NECR) measurements with the NEMA cylinder (20 cm diameter) were repeated for two larger cylinders (27 cm and 35 cm diameter), which better represent average and heavy patients. A NEMA/IEC torso phantom was used for overall assessment of image quality. The transverse and axial resolution near the center was 4.7 mm. Timing and energy resolution of the PET–MR system were measured to be 525 ps and 12%, respectively. The results were comparable to PET–CT systems demonstrating that the effect of design modifications required on the PET system to remove the harmful effect of the magnetic field on the PMTs was negligible. The absolute sensitivity of this scanner was 7.0 cps kBq−1, whereas SF was 26%. NECR measurements performed with cylinders having three different diameters, and image quality measurements performed with IEC phantom yielded excellent results. The Ingenuity TF PET–MRI represents the first commercial whole-body hybrid PET–MRI system. The performance of the PET subsystem was comparable to the GEMINI TF PET–CT system using phantom and patient studies. It is conceived

  13. Design and performance evaluation of a whole-body Ingenuity TF PET-MRI system.

    PubMed

    Zaidi, H; Ojha, N; Morich, M; Griesmer, J; Hu, Z; Maniawski, P; Ratib, O; Izquierdo-Garcia, D; Fayad, Z A; Shao, L

    2011-05-21

    The Ingenuity TF PET-MRI is a newly released whole-body hybrid PET-MR imaging system with a Philips time-of-flight GEMINI TF PET and Achieva 3T X-series MRI system. Compared to PET-CT, modifications to the positron emission tomography (PET) gantry were made to avoid mutual system interference and deliver uncompromising performance which is equivalent to the standalone systems. The PET gantry was redesigned to introduce magnetic shielding for the photomultiplier tubes (PMTs). Stringent electromagnetic noise requirements of the MR system necessitated the removal of PET gantry electronics to be housed in the PET-MR equipment room. We report the standard NEMA measurements for the PET scanner. PET imaging and performance measurements were done at Geneva University Hospital as described in the NEMA Standards NU 2-2007 manual. The scatter fraction (SF) and noise equivalent count rate (NECR) measurements with the NEMA cylinder (20 cm diameter) were repeated for two larger cylinders (27 cm and 35 cm diameter), which better represent average and heavy patients. A NEMA/IEC torso phantom was used for overall assessment of image quality. The transverse and axial resolution near the center was 4.7 mm. Timing and energy resolution of the PET-MR system were measured to be 525 ps and 12%, respectively. The results were comparable to PET-CT systems demonstrating that the effect of design modifications required on the PET system to remove the harmful effect of the magnetic field on the PMTs was negligible. The absolute sensitivity of this scanner was 7.0 cps kBq(-1), whereas SF was 26%. NECR measurements performed with cylinders having three different diameters, and image quality measurements performed with IEC phantom yielded excellent results. The Ingenuity TF PET-MRI represents the first commercial whole-body hybrid PET-MRI system. The performance of the PET subsystem was comparable to the GEMINI TF PET-CT system using phantom and patient studies. It is conceived that advantages

  14. BOREAS TF-2 SSA-OA Tower Flux, Meteorological, and Precipitation Data

    NASA Technical Reports Server (NTRS)

    Neumann, Harold; Mickle, Robert; Staebler, Ralf; Hall, Forrest G. (Editor); Huemmrich, Karl (Editor)

    2000-01-01

    The BOReal Ecosystem-Atmosphere Study Tower Flux-2 (BOREAS TF-2) team collected energy, carbon dioxide, water vapor, and momentum flux data above the canopy and in profiles through the canopy, along with meteorological data at the BOREAS Southern Study Area-Old Aspen (SSA-OA) site. Above-canopy measurements began in early February and ran through mid-September of 1994. Measurements were collected over a longer period of 1994 than most BOREAS flux sites. Daily precipitation data from several gauges were also collected. The data are available in tabular ASCII files.

  15. Intranasal administration of aTf protects and repairs the neonatal white matter after a cerebral hypoxic-ischemic event.

    PubMed

    Guardia Clausi, Mariano; Paez, Pablo M; Campagnoni, Anthony T; Pasquini, Laura A; Pasquini, Juana M

    2012-10-01

    Our previous studies showed that the intracerebral injection of apotransferrin (aTf) attenuates white matter damage and accelerates the remyelination process in a neonatal rat model of cerebral hypoxia-ischemia (HI) injury. However, the intracerebral injection of aTf might not be practical for clinical treatments. Therefore, the development of less invasive techniques capable of delivering aTf to the central nervous system would clearly aid in its effective clinical use. In this work, we have determined whether intranasal (iN) administration of human aTf provides neuroprotection to the neonatal mouse brain following a cerebral hypoxic-ischemic event. Apotransferrin was infused into the naris of neonatal mice and the HI insult was induced by right common carotid artery ligation followed by exposure to low oxygen concentration. Our results showed that aTf was successfully delivered into the neonatal HI brain and detected in the olfactory bulb, forebrain and posterior brain 30 min after inhalation. This treatment successfully reduced white matter damage, neuronal loss and astrogliosis in different brain regions and enhanced the proliferation and survival of oligodendroglial progenitor cells (OPCs) in the subventricular zone and corpus callosum (CC). Additionally, using an in vitro hypoxic model, we demonstrated that aTf prevents oligodendrocyte progenitor cell death by promoting their differentiation. In summary, these data suggest that iN administration of aTf has the potential to be used for clinical treatment to protect myelin and to induce remyelination in demyelinating hypoxic-ischemic events in the neonatal brain. PMID:22736466

  16. Characteristics of Ceramic Coatings Made by Thin Film Low Pressure Plasma Spraying (LPPS-TF)

    NASA Astrophysics Data System (ADS)

    Hospach, Andreas; Mauer, Georg; Vaßen, Robert; Stöver, Detlev

    2012-06-01

    The thin film low pressure plasma spray process (LPPS-TF) has been developed with the aim of efficient depositing uniform and thin coatings with large area coverage by plasma spraying. At high power input (~150 kW) and very low pressure (~100 Pa) the plasma jet properties change considerably and it is even possible to evaporate the powder feedstock material providing advanced microstructures of the deposits. This relatively new technique bridges the gap between conventional plasma spraying and physical vapor deposition. In addition, the resulting microstructures are unique and can hardly be obtained by other processes. In this paper, microstructures made by LPPS-TF are shown and the columnar layer growth by vapor deposition is demonstrated. In addition to the ceramic materials TiO2, Al2O3 or MgAl2O4, the focus of the research was placed on partially yttria-stabilized zirconia. Variations of the microstructures are shown and discussed concerning potential coating applications.

  17. Cryogenic Test Results of the ITER TF Model Coil Test in TOSKA

    NASA Astrophysics Data System (ADS)

    Zahn, G.; Bagnasco, M.; Darweschsad, M.; Dittrich, G.; Duchateau, J. L.; Fillunger, H.; Fietz, W. H.; Fink, S.; Fuhrman, U.; Heger, R.; Heller, R.; Herz, W.; Komarek, P.; Kienzler, A.; Langhans, O.; Lehmann, W.; Lingor, A.; Meyer, I.; Neumann, H.; Nicollet, S.; Noether, G.; Roehrling, M.; Savoldi-Richard, L.; Specht, E.; Süsser, M.; Ulbricht, A.; Wuechner, F.; Zanino, R.

    2004-06-01

    The ITER Toroidal Field Model Coil (TFMC) was designed and manufactured by the European Home Team in collaboration with European industry. The test in the TOSKA facility of the Forschungszentrum Karlsruhe was successfully performed in 2001 and 2002 and has confirmed that the used design and construction principles are applicable for the ITER TF coils. The TFMC was tested up to the rated current of 80 kA as a single coil and in the background field of the EURATOM LCT coil in order to achieve ITER TF coil relevant stress levels. For the operation of the TFMC and LCT coils, special developed forced-flow-cooled current leads were used. Both coils with a total weight of 108 t were forced-flow-cooled with supercritical He at 4.5 K in a secondary cooling loop connected to the 2 kW refrigerator. However, for currents above 11.4 kA in the LCT coil, its winding had to be cooled at 3.0 K with a separate refrigerator and cooling system. Details of the process engineering of both cooling systems will be described. The operation experiences during cool down, standby and current operation and recooling after fast discharges or Tcs measurements will be outlined hereafter.

  18. TF2 binds to the regulatory promoter of alkaline phosphatase in Dicytostelium.

    PubMed

    Joyce, Bradley R; Wiles, Natasha S; Rutherford, Charles L

    2007-01-01

    Alkaline phosphatase (ALP) activity becomes restricted to PstO cells at the prestalk-prespore boundary during the later stages of development, suggesting a novel function in the regulation of prestalk cell differentiation. To identify regulatory control sequences within the alp promoter, a series of 5' and internal deletions were generated and fused to the LacZ reporter gene. In vitro assays of reporter activity from Dicytostelium transformants containing the deleted promoter-LacZ fusion constructs showed that the -683 to -468 bp sequence is required for proper activation of the reporter in developing slugs. To identify DNA-protein interactions involved in the regulation of alp, EMSAs were preformed using a series of short overlapping PCR probes that span the regulatory promoter sequence. A sequence-specific DNA-binding protein was identified that interacts with the -665 to -635 bp sequence. This DNA-binding protein was sequentially purified using DEAE-Sephacel, heparin-Sepharose, DNA Affinity, and gel filtration chromatography. A polypeptide with a molecular weight of 28 kDa was identified on an SDS-PAGE. The purified protein was identified as TF2 by mass spectrometry. TF2 may, therefore, bind to the regulatory promoter of alp and function in the developmental control of PstO differentiation in Dicytostelium. PMID:17916391

  19. Mechanical behavior of the ITER TF model coil ground insulation system after reactor irradiation

    NASA Astrophysics Data System (ADS)

    Bittner-Rohrhofer, K.; Humer, K.; Fillunger, H.; Maix, R. K.; Weber, H. W.

    2002-11-01

    The mechanical properties of glass fiber reinforced plastics (GFRPs) suggested for the turn and ground insulation of the ITER toroidal field (TF) coils are subject to extensive investigations with respect to their design requirements at present. The insulation system used for the ITER TF model coil, manufactured by European industry, consists of a boron-free R-glass fiber reinforced tape, vacuum-pressure impregnated in a DGEBA epoxy system and partly interleaved with polyimide-foils (e.g. Kapton-H-foils). In order to assess the material performance under the actual operating conditions of ITER-FEAT, the system was irradiated in the TRIGA reactor (Vienna, Austria) to neutron fluences of 5×10 21 and 1×10 22 m -2 ( E>0.1 MeV). The composite was screened at 77 K using static tensile, short-beam-shear (SBS) as well as double-lap-shear tests prior to and after irradiation. Furthermore, tension-tension fatigue measurements were done in order to simulate the pulsed ITER-FEAT operation. We observe that the mechanical strength and the fracture behavior of these GFRPs after irradiation are strongly influenced by the three factors: the winding direction of the tape, the quality of fabrication and the delamination process.

  20. Eukaryotic and archaeal TBP and TFB/TF(II)B follow different promoter DNA bending pathways.

    PubMed

    Gietl, Andreas; Holzmeister, Phil; Blombach, Fabian; Schulz, Sarah; von Voithenberg, Lena Voith; Lamb, Don C; Werner, Finn; Tinnefeld, Philip; Grohmann, Dina

    2014-06-01

    During transcription initiation, the promoter DNA is recognized and bent by the basal transcription factor TATA-binding protein (TBP). Subsequent association of transcription factor B (TFB) with the TBP-DNA complex is followed by the recruitment of the ribonucleic acid polymerase resulting in the formation of the pre-initiation complex. TBP and TFB/TF(II)B are highly conserved in structure and function among the eukaryotic-archaeal domain but intriguingly have to operate under vastly different conditions. Employing single-pair fluorescence resonance energy transfer, we monitored DNA bending by eukaryotic and archaeal TBPs in the absence and presence of TFB in real-time. We observed that the lifetime of the TBP-DNA interaction differs significantly between the archaeal and eukaryotic system. We show that the eukaryotic DNA-TBP interaction is characterized by a linear, stepwise bending mechanism with an intermediate state distinguished by a distinct bending angle. TF(II)B specifically stabilizes the fully bent TBP-promoter DNA complex and we identify this step as a regulatory checkpoint. In contrast, the archaeal TBP-DNA interaction is extremely dynamic and TBP from the archaeal organism Sulfolobus acidocaldarius strictly requires TFB for DNA bending. Thus, we demonstrate that transcription initiation follows diverse pathways on the way to the formation of the pre-initiation complex. PMID:24744242

  1. Regulation of mitochondrial morphology and function by Stearoylation of TfR1

    PubMed Central

    Senyilmaz, Deniz; Virtue, Sam; Xu, Xiaojun; Tan, Chong Yew; Griffin, Julian L; Miller, Aubry K.; Vidal-Puig, Antonio; Teleman, Aurelio A.

    2015-01-01

    Summary Mitochondria are involved in a variety of cellular functions including ATP production, amino acid and lipid biogenesis and breakdown, signaling and apoptosis1-3. Mitochondrial dysfunction has been linked to neurodegenerative diseases, cancer, and aging4. Although transcriptional mechanisms regulating mitochondrial abundance are known5, comparatively little is known about how mitochondrial function is regulated. We identify here the metabolite stearic acid (C18:0) and Transferrin Receptor (TfR1) as mitochondrial regulators. We elucidate a signaling pathway whereby C18:0 stearoylates TfR1, thereby inhibiting its activation of JNK signaling. This leads to reduced ubiquitination of mitofusin via HUWE1, thereby promoting mitochondrial fusion and function. We find that animal cells are poised to respond to both increases and decreases in C18:0 levels, with increased C18:0 dietary intake boosting mitochondrial fusion in vivo. Intriguingly, dietary C18:0 supplementation can counteract the mitochondrial dysfunction caused by genetic defects such as loss of the Parkinsons genes Pink or Parkin. This work identifies the metabolite C18:0 as a signaling molecule regulating mitochondrial function in response to diet. PMID:26214738

  2. High-performance TF coil design for the Toroidal Fusion Core Experiment (TFCX)

    NASA Astrophysics Data System (ADS)

    Strivastava, V. C.

    1984-09-01

    The Toroidal Fusion Core Experiment (RFCX) is a proposed concept for an ignited, long-pulse, current-driven Tokamak device. The TF coil winding cross section in the inboard region is impacted by peak field 10 T, winding current density approx. 3500 A/cm(2), and peak nuclear heating rates 50 mW/cc. The winding utilizes a Nb3Sn internally cooled cable superconductor (ICCS), which is a modified version of the conductor used in the Westinghouse LCP coil. These modifications include the increase of void fraction from 32% to 41% of the cable space for withstanding higher nuclear heating rates and a thicker conduit wall to carry larger magnetic loads. The critical current of an Nb3Sn conductor is strongly dependent on strain in the superconducting strands. The strain in strands is lower when the windings are: (1) wound and then reacted (W/R), as compared to (2) reacted and then wound (R/W). The impact of these approaches on winding performance is discussed. The windings are pancake wound and cooled with supercritical helium. The LHe inlet (approx. 4 K) and outlet (approx. 5.5 K) connections are located on the sides of the TF coils. The conductor design, the winding design, and performance analysis are described.

  3. Design of a TF34 turbofan mixer for reduction of flap impingement noise

    NASA Technical Reports Server (NTRS)

    Chamay, A.; Edkins, D. P.; Mishler, R. B.; Clapper, W. S.

    1972-01-01

    This portion of the TF-34 turbofan quiet engine studies has been devoted to the selection and design of a special mixer exhaust nozzle system to reduce the maximum 150 m (500 foot) sideline noise generated by the impingement of four engine exhausts on a STOL wing flap system to less than 92 PNdB. The design concept selected consists of a 12-lobe internal mixer and a 12-lobe external mixer mounted in series. The internal mixer reduces maximum exhaust velocities by mixing the fan and turbine streams. The external mixer is designed to reduce the velocity of the exhaust stream striking the wing flap surfaces. A ground test version of this concept has been designed to be installed and tested on an acoustically treated TF-34 engine nacelle, with flexibility to simulate a flight version of this concept which has also been defined. Estimated noise levels are 2 PNdB below the objective at approach and 2 PNdB above the objective at takeoff, with an uncertainty band of +3, -2 PNdB.

  4. Demountable, High field High-Temperature Superconductor TF coils for flexible steady-state fusion experiments

    NASA Astrophysics Data System (ADS)

    Michael, Phillip; Bromberg, Leslie; Vieira, Rui; Minervini, Joseph; Galea, Christopher; Hensley, Sarah; Whyte, Dennis

    2014-10-01

    The excellent properties of HTS materials (e.g., YBCO) at high fields and elevated temperatures (>20 K), offer operational advantages for fusion machines, but results in challenges. For fusion devices, the ability to disassemble the TF coil is very attractive as it provides direct access to maintain the vacuum vessel, first wall and other components in a timely manner. High current conductors, made from multiple thin tapes, are not available but are being developed. Quench protection is a serious issue with HTS magnets, and novel means are needed to detect normal zones and to quickly discharge the magnet. Potential cables designs, demountable magnets and solutions to quench and protection issues for an HTS TF magnet for the Vulcan device (long term PMI studies) will be described. We also describe means for making continuous, persistent loops with HTS tapes. These loops offer an alternative to expensive monoliths for field control for complex geometries, such as stellarator-like fields. Partially supported by US DOE DE-FC02-93ER54186.

  5. Results of the TF conductor performance qualification samples for the ITER project

    NASA Astrophysics Data System (ADS)

    Breschi, M.; Devred, A.; Casali, M.; Bessette, D.; Jewell, M. C.; Mitchell, N.; Pong, I.; Vostner, A.; Bruzzone, P.; Stepanov, B.; Boutboul, T.; Martovetsky, N.; Kim, K.; Takahashi, Y.; Tronza, V.; Yu, Wu

    2012-09-01

    The performance of the toroidal field (TF) magnet conductors for the ITER machine are qualified by a short full-size sample (4 m) current sharing temperature (Tcs) test in the SULTAN facility at CRPP in Villigen, Switzerland, using the operating current of 68 kA and the design peak field of 11.8 T. Several samples, including at least one from each of the six ITER Domestic Agencies participating in TF conductor fabrication (China, European Union, Japan, Russia, South Korea and the United States), have been qualified by the ITER Organization after achieving Tcs values of 6.0-6.9 K, after 700-1000 electromagnetic cycles. These Tcs values exceed the ITER specification and enabled the industrial production of these long-lead items for the ITER tokamak to begin in each Domestic Agency. Some of these samples did not pass the qualification test. In this paper, we summarize the performance of the qualified samples, analyze the effect of strand performance on conductor performance, and discuss the details of the test results.

  6. Limits to T/TF and progress towards ultracold ^6Li-^87Rb mixtures

    NASA Astrophysics Data System (ADS)

    Brown-Hayes, Michael; Wei, Qun; Kim, Woo-Joong; Presilla, Carlo; Onofrio, Roberto

    2007-03-01

    Ultracold dilute atomic gases are providing a new window into quantum physics, with particular regard to the first-principle study of superfluid phenomena. Fermionic degeneracy (measured by T/TF) achieved with current apparata using sympathetic cooling techniques seems to be limited by the heat capacity matching between the Fermi and Bose species and by Fermi-hole heating. We will discuss these factors and report on the development of an apparatus for simultaneous trapping and cooling of ^6Li and ^87Rb, using a light-assisted magnetic trap. The ^6Li and ^87Rb species combination, in conjunction with the improvement in heat capacity matching, should allow for an improved lower limit to attainable temperatures in Fermi-Bose mixtures. We also report on seemingly opposite approaches to reaching a lower T/TF and suggest the differences are due to two distinct measures of cooling efficiency. M. Brown-Hayes and R. Onofrio, Phys. Rev. A 70, 063614 (2004). R. Côt'e, R. Onofrio, E. Timmermans, Phys. Rev. A 72, 041605(R) (2005).

  7. TFTR D&D Project: Final Examination and Testing of the TFTR TF-Coils

    SciTech Connect

    Irving J. Zatz

    2003-01-31

    In operation for nearly 15 years, TFTR (Tokamak Fusion Test Reactor) was not only a fusion science milestone, but a milestone of achievement in engineering as well. The TFTR D&D (Decommissioning and Decontamination) program provided a rare opportunity to examine machine components that had been exposed to a unique performance environment of greater than 100,000 mechanical and thermal load cycles. In particular, the possible examination of the TFTR toroidal-field (TF) coils, which met, then exceeded, the 5.2 Tesla magnetic field machine specification, could supply the answers to many questions that have been asked and debated since the coils were originally designed and built. A test program conducted in parallel with the D&D effort was the chance to look inside and examine, in detail, the TFTR TF coils for the first time since they were delivered encased to PPPL (Princeton Plasma Physics Laboratory). The results from such a program would provide data and insight that would not only be nefit PPPL and the fusion community, but the broader scientific community as well.

  8. Dreams and Reality of Using Naked Ge Detectors in Liquid Nitrogen Status (Long-Term Stability) of GENIUS-TF

    NASA Astrophysics Data System (ADS)

    Krivosheina, Irina V.; Klapdor-Kleingrothaus, Hans V.

    2008-04-01

    GENIUS-TF-II is a setup of six naked high purity Ge detectors (15 kg) in liquid nitrogen in Gran Sasso. It has been installed in October, 2004 - after the first four naked Ge detectors had been installed on May 5, 2003 (GENIUS-TF-I). The GENIUS-Test-Facility (GENIUS-TF) is the first and up to now only setup ever testing the novel technique aiming at extreme background reduction in search for rare decays in particular underground. The goal of GENIUS-TF was to test some key operational parameters of the full GENIUS project in 1997.1-6 Simultaneous physical goal was to search for the annual modulation of the Dark Matter signal.12,25 After operation of GENIUS-TF over three years with finally six naked Ge detectors (15 kg) in liquid nitrogen in Gran Sasso we realize serious problems for realization of a full-size GENIUS-like experiment: 1. Background from 222Rn diffusing into the setup, on a level far beyond the expectation. 2. Limited long-term stability of naked detectors in liquid nitrogen as result of increasing leakage current. None of the six detectors is running after three years with the nominal leakage current. Three of the six detectors do not work any more at all. The results of our three years of investigation of the long-term stability casts serious doubt on the possibility to perform a full GENIUS project - or its copies GERDA or CAMEO/GEM.

  9. Identifying Cancer Subtypes from miRNA-TF-mRNA Regulatory Networks and Expression Data

    PubMed Central

    Liu, Lin; Wang, Rujing; Sun, Bingyu; Li, Jiuyong

    2016-01-01

    Background Identifying cancer subtypes is an important component of the personalised medicine framework. An increasing number of computational methods have been developed to identify cancer subtypes. However, existing methods rarely use information from gene regulatory networks to facilitate the subtype identification. It is widely accepted that gene regulatory networks play crucial roles in understanding the mechanisms of diseases. Different cancer subtypes are likely caused by different regulatory mechanisms. Therefore, there are great opportunities for developing methods that can utilise network information in identifying cancer subtypes. Results In this paper, we propose a method, weighted similarity network fusion (WSNF), to utilise the information in the complex miRNA-TF-mRNA regulatory network in identifying cancer subtypes. We firstly build the regulatory network where the nodes represent the features, i.e. the microRNAs (miRNAs), transcription factors (TFs) and messenger RNAs (mRNAs) and the edges indicate the interactions between the features. The interactions are retrieved from various interatomic databases. We then use the network information and the expression data of the miRNAs, TFs and mRNAs to calculate the weight of the features, representing the level of importance of the features. The feature weight is then integrated into a network fusion approach to cluster the samples (patients) and thus to identify cancer subtypes. We applied our method to the TCGA breast invasive carcinoma (BRCA) and glioblastoma multiforme (GBM) datasets. The experimental results show that WSNF performs better than the other commonly used computational methods, and the information from miRNA-TF-mRNA regulatory network contributes to the performance improvement. The WSNF method successfully identified five breast cancer subtypes and three GBM subtypes which show significantly different survival patterns. We observed that the expression patterns of the features in some miRNA-TF

  10. BOREAS TF-4 CO2 and CH4 Soil Profile Data from the SSA

    NASA Technical Reports Server (NTRS)

    Striegl, Robert; Wickland, Kimberly; Hall, Forrest G. (Editor); Conrad, Sara (Editor)

    2000-01-01

    The BOReal Ecosystem-Atmosphere Study Tower Flux (BOREAS TF-4) team measured distributions of carbon dioxide (CO2) and methane (CH4) concentrations for the upper 5 m of soil and unsaturated zone at the mature stand, upper 6 m at the 20-year-old stand, and the upper 1 m at the 8-year-old stand and clear cut area at the BOREAS Southern Study Area (SSA) during August 1993 to March 1995. Particle size and carbon content of the unsaturated deposits, precipitation, soil temperature and moisture, carbon and oxygen isotopes of soil CO2, and soil water chemistry are also presented. The data are stored in tabular ASCII files.

  11. Computational approach towards promoter sequence comparison via TF mapping using a new distance measure.

    PubMed

    Meera, A; Rangarajan, Lalitha; Bhat, Savithri

    2011-03-01

    We propose a method for identifying transcription factor binding sites (TFBS) in the given promoter sequence and mapping the transcription factors (TFs). The proposed algorithm searches the +1 transcription start site (TSS) for eukaryotic and prokaryotic sequences individually. The algorithm was tested with sequences from both eukaryotes and prokaryotes for at least 9 experimentally verified and validated functional TFs in promoter sequences. The order and type of TF binding to the promoter of genes encoding central metabolic pathway (CMP) enzyme was tabulated. A new similarity measure was devised for scoring the similarity between a pair of promoter sequences based on the number and order of motifs. Further, these were grouped in clusters considering the scores between them. The distance between each of the clusters in individual pathway was calculated and a phylogenetic tree was developed. This method is further applied to other pathways such as lipid and amino acid biosynthesis to retrieve and compare experimentally verified and conserved TFBS. PMID:21369887

  12. BOREAS TF-3 Automated Chamber CO2 Flux Data from the NSA-OBS

    NASA Technical Reports Server (NTRS)

    Goulden, Michael L.; Crill, Patrick M.; Hall, Forrest G. (Editor); Conrad, Sara (Editor)

    2000-01-01

    The BOReal Ecosystem Atmosphere Study Tower Flux (BOREAS TF-3) and Trace Gas Biogeochemistry (TGB-1) teams collected automated CO2 chamber flux data in their efforts to fully describe the CO2 flux at the Northern Study Area-Old Black Spruce (NSA-OBS) site. This data set contains fluxes of CO2 at the NSA-OBS site measured using automated chambers. In addition to reporting the CO2 flux, it reports chamber air temperature, moss temperature, and light levels during each measurement. The data set covers the period from 23-Sep-1995 through 26-Oct-1995 and from 28-May-1996 through 21-Oct-1996. The data are stored in tabular ASCII files.

  13. Design, synthesis, and biological evaluation of pyrazinones containing novel P1 needles as inhibitors of TF/VIIa.

    PubMed

    Trujillo, John I; Huang, Horng-Chih; Neumann, William L; Mahoney, Matthew W; Long, Scott; Huang, Wei; Garland, Danny J; Kusturin, Carrie; Abbas, Zaheer; South, Michael S; Reitz, David B

    2007-08-15

    Herein is described the design, synthesis, and enzymatic activity of a series of substituted pyrazinones as inhibitors of the TF/VIIa complex. These inhibitors were designed to explore replacement and variation of the P1 amidine described previously [J. Med. Chem.2003, 46, 4050]. The P1 needle replacements were selected based upon their reduced basicity compared to the parent phenyl amidine (pKa approximately 12). A contributing factor towards the oral bioavailability of a compound is the ionization state of the compound in the intestinal tract. The desired outcome of the study was to identify an orally bioavailable TF-VIIa inhibitor. PMID:17566736

  14. Personality Disorders

    MedlinePlus

    ... this page You are here Home » Personality Disorder Personality Disorder What is “Personality?” Personality refers to a distinctive set of traits, ... family, friends, and co-workers. What is a Personality Disorder? Those who struggle with a personality disorder ...

  15. Interleukin-6 Directly Impairs the Erythroid Development of Human TF-1 Erythroleukemic Cells

    PubMed Central

    McCranor, Bryan J.; Kim, Min Jung; Cruz, Nicole M.; Xue, Qian-Li; Berger, Alan E.; Walston, Jeremy D.; Civin, Curt I.; Roy, Cindy N.

    2013-01-01

    Anemia of inflammation or chronic disease is a highly prevalent form of anemia. The inflammatory cytokine interleukin-6 (IL-6) negatively correlates with hemoglobin concentration in many disease states. The IL-6-hepcidin antimicrobial peptide axis promotes iron-restricted anemia; however the full role of IL-6 in anemia of inflammation is not well-defined. We previously reported that chronic inflammation had a negative impact on maturation of erythroid progenitors in a mouse model. We hypothesized that IL-6 may be responsible for impaired erythropoiesis, independent of iron restriction. To test the hypothesis we utilized the human erythroleukemia TF-1 cell line to model erythroid maturation and exposed them to varying doses of IL-6 over six days. At 10 ng/ml, IL-6 significantly repressed erythropoietin-dependent TF-1 erythroid maturation. While IL-6 did not decrease the expression of genes associated with hemoglobin synthesis, we observed impaired hemoglobin synthesis as demonstrated by decreased benzidine staining. We also observed that IL-6 down regulated expression of the gene SLC4a1 which is expressed late in erythropoiesis. Those findings suggested that IL-6-dependent inhibition of hemoglobin synthesis might occur. We investigated the impact of IL-6 on mitochondria. IL-6 decreased the mitochondrial membrane potential at all treatment doses, and significantly decreased mitochondrial mass at the highest dose. Our studies indicate that IL-6 may impair mitochondrial function in maturing erythroid cells resulting in impaired hemoglobin production and erythroid maturation. Our findings may indicate a novel pathway of action for IL-6 in the anemia of inflammation, and draw attention to the potential for new therapeutic targets that affect late erythroid development. PMID:24119518

  16. APT Blanket Detailed Bin Model Based on Initial Plate-Type Design -3D FLOWTRAN-TF Model

    SciTech Connect

    Hamm, L.L.

    1998-10-07

    This report provides background information for a series of reports documenting accident scenario simulations for the Accelerator Production of Tritium (APT) blanket heat removal systems. The simulations were performed in support of the Preliminary Safety Analysis Report for the APT. This report gives a brief description of the FLOWTRAN-TF code which was used for detailed blanket bin modeling.

  17. Inhibitory activity of Lactobacillus plantarum TF711 against Clostridium sporogenes when used as adjunct culture in cheese manufacture.

    PubMed

    González, Lorena; Zárate, Victoria

    2015-05-01

    Bacteriocins produced by lactic acid bacteria are of great interest to the food-processing industry as natural preservatives. This work aimed to investigate the efficacy of bacteriocin-producing Lactobacillus plantarum TF711, isolated from artisanal Tenerife cheese, in controlling Clostridium sporogenes during cheese ripening. Cheeses were made from pasteurised milk artificially contaminated with 10(4) spores m/l C. sporogenes. Experimental cheeses were manufactured with Lb. plantarum TF711 added at 1% as adjunct to commercial starter culture. Cheeses made under the same conditions but without Lb. plantarum TF711 served as controls. Evolution of microbiological parameters, pH and NaCl content, as well as bacteriocin production was studied throughout 45 d of ripening. Addition of Lb. plantarum TF711 did not bring about any significant change in starter culture counts, NaCl content and pH, compared with control cheese. In contrast, clostridial spore count in experimental cheeses were significantly lower than in control cheeses from 7 d onwards, reaching a maximum reduction of 2·2 log units on day 21. Inhibition of clostridia found in experimental cheeses was mainly attributed to plantaricin activity, which in fact was recovered from these cheeses. PMID:25702615

  18. Personality and Fibromyalgia Syndrome

    PubMed Central

    Malin, Katrina; Littlejohn, Geoffrey O

    2012-01-01

    Objectives: We aimed to review how personality characteristics contribute to the onset, maintenance or modulation of fibromyalgia. Method: The databases Medline and PsychINFO were examined from 1967 to 2012 to identify studies that investigated associations between fibromyalgia and personality. Search terms included fibromyalgia and personality, trait psychology, characteristics and individual differences. Results: Numerous studies indicate that patients with fibromyalgia experience psychological distress. Various instruments have been used to evaluate distress and related psychological domains, such as anxiety or depression, in fibromyalgia. In many cases, these same instruments have been used to study personality characteristics in fibromyalgia with a subsequent blurring of cause and effect between personality and psychological distress. In addition, the symptoms of fibromyalgia may change pre-illness personality characteristics themselves. These issues make it difficult to identify specific personality characteristics that might influence the fibromyalgia process. Despite this inherent problem with the methodologies used in the studies that make up this literature review, or perhaps because of it, we found no defined personality profile specific to fibromyalgia. However, many patients with fibromyalgia do show personality characteristics that facilitate psychological responses to stressful situations, such as catastrophising or poor coping techniques, and these in turn associate with mechanisms contributing to fibromyalgia. Conclusion: No specific fibromyalgia personality is defined but it is proposed that personality is an important filter that modulates a person’s response to psychological stressors. Certain personalities may facilitate translation of these stressors to physiological responses driving the fibromyalgia mechanism. PMID:23002409

  19. COUP-TF interacting protein 2 represses the initial phase of HIV-1 gene transcription in human microglial cells

    PubMed Central

    Marban, Céline; Redel, Laetitia; Suzanne, Stella; Van Lint, Carine; Lecestre, Dominique; Chasserot-Golaz, Sylvette; Leid, Mark; Aunis, Dominique; Schaeffer, Evelyne; Rohr, Olivier

    2005-01-01

    Human immunodeficiency virus type 1 (HIV-1) gene transcription is characterized by two temporally distinct phases. While the initial phase relies solely on cellular transcription factors, the subsequent phase is activated by the viral Tat transactivator. We have previously reported that the subsequent phase of viral gene transcription can be repressed by the chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2 (CTIP2) in human microglial cells [O. Rohr, D. Lecestre, S. Chasserot-Golaz, C. Marban, D. Avram, D. Aunis, M. Leid and E. Schaeffer (2003), J. Virol., 77, 5415–5427]. Here, we demonstrate that CTIP proteins also repress the initial phase of HIV-1 gene transcription, mainly supported by the cellular transcription factors Sp1 and COUP-TF in microglial cells. We report that CTIP2 represses Sp1- and COUP-TF-mediated activation of HIV-1 gene transcription and viral replication as a result of physical interactions with COUP-TF and Sp1 in microglial nuclei. Using laser confocal microscopy CTIP2 was found to colocalize with Sp1, COUP-TF and the heterochromatin-associated protein Hp1α, which is mainly detected in transcriptionally repressed heterochromatic region. Moreover, we describe that CTIP2 can be recruited to the HIV-1 promoter via its association with Sp1 bound to the GC-box sequences of the long terminal repeat (LTR). Since our findings demonstrate that CTIP2 interacts with the HIV-1 proximal promoter, it is likely that CTIP2 promotes HIV-1 gene silencing by forcing transcriptionally repressed heterochromatic environment to the viral LTR region. PMID:15849318

  20. Asking the Right Questions about Leadership: Discussion and Conclusions

    ERIC Educational Resources Information Center

    Hackman, J. Richard; Wageman, Ruth

    2007-01-01

    Five questions prompted by the articles in the American Psychologist special issue on leadership (January 2007, Vol. 62, No. 1) suggest some new directions for leadership research: (1) Not do leaders make a difference, but under what conditions does leadership matter? (2) Not what are the traits of leaders, but how do leaders' personal attributes…

  1. Personality disorders

    MedlinePlus

    Personality disorders are a group of mental conditions in which a person has a long-term pattern ... Causes of personality disorders are unknown. Genetic and environmental factors are thought to play a role. Mental health professionals categorize these ...

  2. 37 CFR 251.52 - Proposed findings and conclusions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... COPYRIGHT ARBITRATION ROYALTY PANEL RULES AND PROCEDURES COPYRIGHT ARBITRATION ROYALTY PANEL RULES OF PROCEDURE Procedures of Copyright Arbitration Royalty Panels § 251.52 Proposed findings and conclusions....

  3. 37 CFR 251.52 - Proposed findings and conclusions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... COPYRIGHT ARBITRATION ROYALTY PANEL RULES AND PROCEDURES COPYRIGHT ARBITRATION ROYALTY PANEL RULES OF PROCEDURE Procedures of Copyright Arbitration Royalty Panels § 251.52 Proposed findings and conclusions....

  4. Lessons after 3 years of running GENIUS-TF in Gran Sasso

    NASA Astrophysics Data System (ADS)

    Krivosheina, I. V.; Klapdor-Kleingrothaus, H. V.

    2006-10-01

    After operation of GENIUS-TF over 3 years with finally six naked Ge detectors (15 kg) in liquid nitrogen in Gran Sasso, we realize serious problems for realization of a full-size GENIUS-like experiment: (i) background from 222Rn diffusing into the setup, on a level far beyond the expectation. (ii) Limited long-term stability of naked detectors in liquid nitrogen. None of the six detectors is running after 3 years with the nominal high voltage. Three of the six detectors do not work at all any more. The HDMS (Heidelberg Dark Matter Search) setup at LNGS, operates the first enriched 73Ge detector worldwide, and looks for spin-dependent WIMP-nucleon coupling at the Gran Sasso Underground Laboratory. The results (85.48 kg d) improve the best present existing limits on the WIMP neutron spin-dependent cross-section (obtained from 129Xe) for low WIMP masses (Klapdor-Kleingrothaus et al 2005 Phys. Lett. B 609 226 31).

  5. Method of discrete modeling and its application to estimation of TF30 engine variables

    NASA Technical Reports Server (NTRS)

    Arpasi, D. J.; Bruton, W. M.

    1976-01-01

    A method of discrete modeling is presented that effectively isolates steady state model accuracy from dynamic model accuracy. The steady state model may be generated from the engine design equations with any desired degree of accuracy. The dynamic model is generated by applying a step disturbance of a manipulated variable to an open loop engine simulation. The sampled response of the variable is combined with the steady state model's response to form a set of weighting factors. These weighting factors are then used to weight past values of the manipulated variable, thus forming the dynamic model. The method is used to estimate various TF30-P-3 engine variables. A dynamic trim function is developed to compensate for the dynamic nonlinearities of the variables as well as for inaccuracies in dynamic definition. The trim function is shown to be realted to the square root of the sum of the squares of the weighting factors obtained at various engine operating conditions. Finally, the estimation of variables without dynamic modeling is discussed.

  6. BOREAS TF-10 NSA-YJP Tower Flux, Meteorological, and Porometry Data

    NASA Technical Reports Server (NTRS)

    McCaughey, J. Harry; Liblik, Laura; Hall, Forrest G. (Editor); Huemmrich, K. (Editor)

    2000-01-01

    The BOREAS TF-10 team collected tower flux and meteorological data at two sites, a fen and a young jack pine forest, near Thompson, Manitoba, Canada, as part of BOREAS. A preliminary data set was assembled in August 1993 while field testing the instrument packages, and at both sites data were collected from 15-Aug to 31-Aug. The main experimental period was in 1994, when continuous data were collected from the young jack pine site from 23-May to 20-Sep. Upon examination of the 1994 data set, it became clear that the behavior of the heat, water, and carbon dioxide fluxes throughout the whole growing season was an important scientific question, and that the 1994 data record was not sufficiently long to capture the character of the seasonal behavior of the fluxes. Thus, the young jack pine site was operated from 08-May to 07-Nov in 1996 in order to collect data from spring melt to autumn freeze-up. All variables are presented as 30-minute averages. Supporting data were also collected to describe the surface#s state and to provide the information, in association with the flux data, to build SVAT models. For the young jack pine site, these supporting data included stomatal conductance measurements. The data are stored in tabular ASCII files.

  7. BOREAS TF-10 NSA-Fen Tower Flux and Meteorological Data

    NASA Technical Reports Server (NTRS)

    McCaughey, J. Harry; Hall, Forrest G. (Editor); Huemmrich, Karl (Editor); Jelinski, Dennis E.

    2000-01-01

    The BOREAS TF-10 team collected tower flux and meteorological data at two sites, a fen and a young jack pine forest, near Thompson, Manitoba, Canada, as part of BOREAS. A preliminary data set was assembled in August 1993 while field testing the instrument packages, and at both sites data were collected from 15-Aug to 31-Aug. The main experimental period was in 1994, when continuous data were collected from 08-Apr to 23-Sep at the fen site. A very limited experiment was run in the spring/ summer of 1995, when the fen site tower was operated from 08-Apr to 14-Jun in support of a hydrology experiment in an adjoining feeder basin. Upon examination of the 1994 data set, it became clear that the behavior of the heat, water, and carbon dioxide fluxes throughout the whole growing season was an important scientific question, and that the 1994 data record was not sufficiently long to capture the character of the seasonal behavior of the fluxes. Thus, the fen site was operated in 1996 in order to collect data from spring melt to autumn freeze-up. Data were collected from 29-Apr to 05-Nov at the fen site. All variables are presented as 30-minute averages. The data are stored in tabular ASCII files.

  8. Ion Pair Structure and Photodissociation Dynamics of Ionic Liquid [EMIM][TF2N

    NASA Astrophysics Data System (ADS)

    Stearns, Jaime A.; Cooper, Russell; Sporleder, David; Zolot, Alexander M.; Boatz, Jerry

    2014-06-01

    The Air Force has a pressing need to find new means of spacecraft propulsion, enabling cheaper, safer, more efficient maneuvering on orbit. Ionic liquids are a potential replacement for hydrazine in hypergolic combustion propellant systems and for xenon in electric propulsion systems. However, both applications require considerable further development, leading us to study the fundamental structural and optical properties of candidate systems. Our benchmark measurements will provide validation of theoretical models of all types, from ab initio methods up to codes describing full thruster plumes. Using standard supersonic jet time-of-flight spectroscopy techniques, we have measured the ultraviolet and infrared spectra of ion pairs of the only space-qualified ionic liquid, [emim][Tf2N]. The ultraviolet photodissociation spectrum, though broad and essentially featureless, reveals rich underlying photodynamics involving both single- and multi-photon excitations and a wealth of interacting excited states. The infrared spectrum and MP2 calculations establish the structure as one in which the cation and anion are stacked on top of one another rather than sitting in the same plane, answering a long-standing question in this field. The complexity of the infrared spectrum and its behavior under varying jet temperatures indicates the presence of multiple conformations and likely contributions from Fermi resonance.

  9. Unraveling novel TF-miRNA regulatory crosstalk in metastasis of Soft Tissue Sarcoma

    PubMed Central

    Samantarrai, Devyani; Sahu, Mousumi; Roy, Jyoti; Mohanty, Bedanta Ballav; Singh, Garima; Bhushan, Chandra; Mallick, Bibekanand

    2015-01-01

    Cancer metastasis is a disease of extreme clinical relevance, as it is responsible for more than 90% of cancer-associated mortality. The molecular mechanism and critical regulators involved in this complex multi-stage process of metastasis is poorly deciphered in soft tissue sarcomas (STS), a heterogeneous group of rare tumors with high metastatic potential. Therefore, we aimed at identifying miRNA and transcription factor (TF) regulatory networks and paths in STS metastasis. We integrated mRNA and miRNA expression profiles with curated regulations (TF→gene, TF→miRNA, miRNA→gene) from different databases and constructed a potentially active regulatory sub-network in STS metastasis. From functional and topological analysis, we found nine novel regulators of Notch signaling sub-network which are conjectured to play critical role in metastasis of STS. This illustrated that the sub-network is promising for identification of critical regulators. Further analysis deploying our developed tool ‘RiNAcyc’ and computing coverage ratio of known STS associated genes and miRNAs identified a 15 node active path. This potential path highlights the crucial role of BMP2, hsa-miR-24, AP2 and MYC as the up-stream regulators of the path and hsa-miR-215 and TYMS as potential indicator of chemotherapeutic benefit in STS metastasis. PMID:25984907

  10. Measurements and predictions of flyover and static noise of a TF30 afterburning turbofan engine

    NASA Technical Reports Server (NTRS)

    Burcham, F. W., Jr.; Lasagna, P. L.; Oas, S. C.

    1978-01-01

    The noise of the TF30 afterburning turbofan engine in an F-111 airplane was determined from static (ground) and flyover tests. A survey was made to measure the exhaust temperature and velocity profiles for a range of power settings. Comparisons were made between predicted and measured jet mixing, internal, and shock noise. It was found that the noise produced at static conditions was dominated by jet mixing noise, and was adequately predicted by current methods. The noise produced during flyovers exhibited large contributions from internally generated noise in the forward arc. For flyovers with the engine at nonafterburning power, the internal noise, shock noise, and jet mixing noise were accurately predicted. During flyovers with afterburning power settings, however, additional internal noise believed to be due to the afterburning process was evident; its level was as much as 8 decibels above the nonafterburning internal noise. Power settings that produced exhausts with inverted velocity profiles appeared to be slightly less noisy than power settings of equal thrust that produced uniform exhaust velocity profiles both in flight and in static testing.

  11. On symbolic models for Single-Conclusion Logic of Proofs

    SciTech Connect

    Krupski, Vladimir N

    2011-05-31

    In this paper we define symbolic models for Single-Conclusion Logics of Proofs. We prove the soundness and completeness of these logics with respect to the corresponding classes of symbolic models. We apply the semantic methods developed in this paper to justify the use of terms of single-conclusion logic of proofs as notation for derivations in this logic. Bibliography: 17 titles.

  12. 10 CFR 2.712 - Proposed findings and conclusions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Proposed findings and conclusions. 2.712 Section 2.712 Energy NUCLEAR REGULATORY COMMISSION AGENCY RULES OF PRACTICE AND PROCEDURE Rules for Formal Adjudications § 2.712 Proposed findings and conclusions. (a) Any party to a proceeding may, or if directed...

  13. 10 CFR 2.712 - Proposed findings and conclusions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Proposed findings and conclusions. 2.712 Section 2.712 Energy NUCLEAR REGULATORY COMMISSION AGENCY RULES OF PRACTICE AND PROCEDURE Rules for Formal Adjudications § 2.712 Proposed findings and conclusions. (a) Any party to a proceeding may, or if directed...

  14. 29 CFR 2700.65 - Proposed findings, conclusions and orders.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 9 2013-07-01 2013-07-01 false Proposed findings, conclusions and orders. 2700.65 Section 2700.65 Labor Regulations Relating to Labor (Continued) FEDERAL MINE SAFETY AND HEALTH REVIEW COMMISSION PROCEDURAL RULES Hearings § 2700.65 Proposed findings, conclusions and orders. The Judge may require the submission of proposed findings of...

  15. 29 CFR 2700.65 - Proposed findings, conclusions and orders.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Proposed findings, conclusions and orders. 2700.65 Section 2700.65 Labor Regulations Relating to Labor (Continued) FEDERAL MINE SAFETY AND HEALTH REVIEW COMMISSION PROCEDURAL RULES Hearings § 2700.65 Proposed findings, conclusions and orders. The Judge may require the submission of proposed findings of...

  16. 49 CFR 511.46 - Proposed findings, conclusions, and order.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 6 2010-10-01 2010-10-01 false Proposed findings, conclusions, and order. 511.46 Section 511.46 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ADJUDICATIVE PROCEDURES Hearings § 511.46 Proposed findings, conclusions, and...

  17. 29 CFR 2700.65 - Proposed findings, conclusions and orders.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 9 2012-07-01 2012-07-01 false Proposed findings, conclusions and orders. 2700.65 Section 2700.65 Labor Regulations Relating to Labor (Continued) FEDERAL MINE SAFETY AND HEALTH REVIEW COMMISSION PROCEDURAL RULES Hearings § 2700.65 Proposed findings, conclusions and orders. The Judge may require the submission of proposed findings of...

  18. Move Sequences in Graduate Research Paper Introductions and Conclusions

    ERIC Educational Resources Information Center

    Madrunio, Marilu Rañosa

    2012-01-01

    Graduate students submit academic papers at the end of the term as part of their coursework. Such papers contain introduction moves which may be troublesome and conclusion moves which may contain sub-moves not really required. This paper is aimed at assessing what particular moves are employed in the introduction and conclusion sections of 21…

  19. 49 CFR 511.46 - Proposed findings, conclusions, and order.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 6 2011-10-01 2011-10-01 false Proposed findings, conclusions, and order. 511.46 Section 511.46 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ADJUDICATIVE PROCEDURES Hearings § 511.46 Proposed findings, conclusions, and...

  20. 39 CFR 952.23 - Proposed findings and conclusions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... submit proposed findings of fact, conclusions of law, orders, and supporting reasons. Unless given orally... record or given consideration. (b) Except when presented orally before the close of the hearing, proposed... proposed findings. Each proposed conclusion shall be separately stated. (c) Except when presented...

  1. The non-structural protein Nsp2TF of porcine reproductive and respiratory syndrome virus down-regulates the expression of Swine Leukocyte Antigen class I.

    PubMed

    Cao, Qian M; Subramaniam, Sakthivel; Ni, Yan-Yan; Cao, Dianjun; Meng, Xiang-Jin

    2016-04-01

    Porcine reproductive and respiratory syndrome virus (PRRSV) is arguably the most economically-important global swine pathogen. Here we demonstrated that PRRSV down-regulates Swine Leukocyte Antigen class I (SLA-I) expression in porcine alveolar macrophages, PK15-CD163 cells and monocyte-derived dendritic cells. To identify the viral protein(s) involved in SLA-I down-regulation, we tested all 22 PRRSV structural and non-structural proteins and identified that Nsp1α and Nsp2TF, and GP3 significantly down-regulated SLA-I expression with Nsp2TF showing the greatest effect. We further generated a panel of mutant viruses in which the Nsp2TF protein synthesis was abolished, and found that the two mutants with disrupted -2 ribosomal frameshifting elements and additional stop codons in the TF domain were unable to down-regulate SLA-I expression. Additionally we demonstrated that the last 68 amino acids of TF domain in Nsp2TF are critical for this function. Collectively, the results indicate a novel function of Nsp2TF in negative modulation of SLA-I expression. PMID:26895249

  2. Thermal analysis of the forced cooled conductor for the TF (toroidal field) superconducting coils in the TIBER II ETR design

    SciTech Connect

    Kerns, J.A.; Slack, D.S.; Miller, J.R.

    1987-06-11

    The Tokamak Ignition/Burn Experimental Reactor (TIBER) is being designed to provide nuclear testing capabilities for first wall and blanket design concepts. The baseline design for TIBER II is to provide steady-state nuclear burn capabilities. These objectives must be met using reactor relevant components, such as state-of-the-art current drive schemes coupled with superconducting toroidal field (TF) and poloidal field (PF) coils. The design is also constrained to be cost effective, which forces the machine to be as small as possible. This last constraint limits the nuclear shielding in TIBER. Therefore, the TF coils will have a high nuclear heat load of up to 4.5 kW per coil. The cooling scheme and the thermal analysis for this design are presented.

  3. Implementation of non-condensable gases condensation suppression model into the WCOBRA/TRAC-TF2 LOCA safety evaluation code

    SciTech Connect

    Liao, J.; Cao, L.; Ohkawa, K.; Frepoli, C.

    2012-07-01

    The non-condensable gases condensation suppression model is important for a realistic LOCA safety analysis code. A condensation suppression model for direct contact condensation was previously developed by Westinghouse using first principles. The model is believed to be an accurate description of the direct contact condensation process in the presence of non-condensable gases. The Westinghouse condensation suppression model is further revised by applying a more physical model. The revised condensation suppression model is thus implemented into the WCOBRA/TRAC-TF2 LOCA safety evaluation code for both 3-D module (COBRA-TF) and 1-D module (TRAC-PF1). Parametric study using the revised Westinghouse condensation suppression model is conducted. Additionally, the performance of non-condensable gases condensation suppression model is examined in the ACHILLES (ISP-25) separate effects test and LOFT L2-5 (ISP-13) integral effects test. (authors)

  4. Fusion of Potentiometric & Voltammetric Electronic Tongue for Classification of Black Tea Taste based on Theaflavins (TF) Content

    NASA Astrophysics Data System (ADS)

    Bhattacharyya, Nabarun; Legin, Andrey; Papieva, Irina; Sarkar, Subrata; Kirsanov, Dmitry; Kartsova, Anna; Ghosh, Arunangshu; Bandyopadhyay, Rajib

    2011-09-01

    Black tea is an extensively consumed beverage worldwide with an expanding market. The final quality of black tea depends upon number of chemical compounds present in the tea. Out of these compounds, theaflavins (TF), which is responsible for astringency in black tea, plays an important role in determining the final taste of the finished black tea. The present paper reports our effort to correlate the theaflavins contents with the voltammetric and potentiometric electronic tongue (e-tongue) data. Noble metal-based electrode array has been used for collecting data though voltammetric electronic tongue where as liquid filled membrane based electrodes have been used for potentiometric electronic tongue. Black tea samples with tea taster score and biochemical results have been collected from Tea Research Association, Tocklai, India for the analysis purpose. In this paper, voltammetric and potentiometric e-tongue responses are combined to demonstrate improvement of cluster formation among tea samples with different ranges of TF values.

  5. Performance evaluation of the Ingenuity TF PET/CT scanner with a focus on high count-rate conditions

    PubMed Central

    Kolthammer, Jeffrey A; Su, Kuan-Hao; Grover, Anu; Narayanan, Manoj; Jordan, David W; Muzic, Raymond F

    2015-01-01

    This study evaluated the positron emission tomography (PET) imaging performance of the Ingenuity TF 128 PET/computed tomography (CT) scanner which has a PET component that was designed to support a wider radioactivity range than is possible with those of Gemini TF PET/CT and Ingenuity TF PET/MR. Spatial resolution, sensitivity, count rate characteristics and image quality were evaluated according to the NEMA NU 2–2007 standard and ACR phantom accreditation procedures; these were supplemented by additional measurements intended to characterize the system under conditions that would be encountered during quantitative cardiac imaging with 82Rb. Image quality was evaluated using a hot spheres phantom, and various contrast recovery and noise measurements were made from replicated images. Timing and energy resolution, dead time, and the linearity of the image activity concentration, were all measured over a wide range of count rates. Spatial resolution (4.8– 5.1 mm FWHM), sensitivity (7.3 cps kBq−1), peak noise-equivalent count rate (124 kcps), and peak trues rate (365 kcps)were similar to those of the Gemini TF PET/CT. Contrast recovery was higher with a 2 mm, body-detail reconstruction than with a 4 mm, body reconstruction, although the precision was reduced. The noise equivalent count rate peak was broad (within 10% of peak from 241–609 MBq). The activity measured in phantom images was within 10% of the true activity for count rates up to those observed in 82Rb cardiac PET studies. PMID:24955921

  6. Preliminary LOCA analysis of the westinghouse small modular reactor using the WCOBRA/TRAC-TF2 thermal-hydraulics code

    SciTech Connect

    Liao, J.; Kucukboyaci, V. N.; Nguyen, L.; Frepoli, C.

    2012-07-01

    The Westinghouse Small Modular Reactor (SMR) is an 800 MWt (> 225 MWe) integral pressurized water reactor (iPWR) with all primary components, including the steam generator and the pressurizer located inside the reactor vessel. The reactor core is based on a partial-height 17x17 fuel assembly design used in the AP1000{sup R} reactor core. The Westinghouse SMR utilizes passive safety systems and proven components from the AP1000 plant design with a compact containment that houses the integral reactor vessel and the passive safety systems. A preliminary loss of coolant accident (LOCA) analysis of the Westinghouse SMR has been performed using the WCOBRA/TRAC-TF2 code, simulating a transient caused by a double ended guillotine (DEG) break in the direct vessel injection (DVI) line. WCOBRA/TRAC-TF2 is a new generation Westinghouse LOCA thermal-hydraulics code evolving from the US NRC licensed WCOBRA/TRAC code. It is designed to simulate PWR LOCA events from the smallest break size to the largest break size (DEG cold leg). A significant number of fluid dynamics models and heat transfer models were developed or improved in WCOBRA/TRAC-TF2. A large number of separate effects and integral effects tests were performed for a rigorous code assessment and validation. WCOBRA/TRAC-TF2 was introduced into the Westinghouse SMR design phase to assist a quick and robust passive cooling system design and to identify thermal-hydraulic phenomena for the development of the SMR Phenomena Identification Ranking Table (PIRT). The LOCA analysis of the Westinghouse SMR demonstrates that the DEG DVI break LOCA is mitigated by the injection and venting from the Westinghouse SMR passive safety systems without core heat up, achieving long term core cooling. (authors)

  7. Oxotremorine treatment reduces repetitive behaviors in BTBR T+ tf/J mice

    PubMed Central

    Amodeo, Dionisio A.; Yi, Julia; Sweeney, John A.; Ragozzino, Michael E.

    2014-01-01

    Repetitive behaviors with restricted interests is one of the core criteria for the diagnosis of autism spectrum disorder (ASD). Current pharmacotherapies that target the dopaminergic or serotonergic systems have limited effectiveness in treating repetitive behaviors. Previous research has demonstrated that administration of muscarinic cholinergic receptor (mAChR) antagonists can exacerbate motor stereotypies while mAChR agonists reduce stereotypies. The present study determined whether the mAChR agonist, oxotremorine affected repetitive behaviors in the BTBR T+ tf/J (BTBR) mouse model of autism. To test the effects of oxotremorine on repetitive behaviors, marble burying and grooming behavior were measured in BTBR mice and compared to that in C57BL/6J (B6) mice. The effects of oxotremorine on locomotor activity was also measured. Thirty minutes before each test, mice received an intraperitoneal (ip) injection of saline, 0.001 mg or 0.01 mg of oxotremorine methiodide. Saline- treated BTBR mice exhibited increased marble burying and self-grooming behavior compared to that of saline-treated B6 mice. Oxotremorine significantly reduced marble burying and self-grooming behavior in BTBR mice, but had no significant effect in B6 mice. In addition, oxotremorine did not affect locomotor activity in BTBR mice, but significantly reduced locomotor activity in B6 mice at the 0.01 mg dose. These findings demonstrate that activation of mAChRs reduces repetitive behavior in the BTBR mouse and suggest that treatment with a mAChR agonist may be effective in reducing repetitive behaviors in ASD. PMID:25165445

  8. Pacer Comet 4: Automated Jet Engine Testing of a TF33-P100 Pratt & Whitney Engine

    NASA Astrophysics Data System (ADS)

    Mason, Rex Bolding

    Pacer Comet 4 found its life out of necessity to replace an obsolescent Pacer Comet 3 engine test system at Tinker AFB in Oklahoma City, OK. Pacer Comet 3 (PC3) was created and installed in the early 1980's to test jet engines from a wide range of planes. PC3 had several problems from a maintenance standpoint: contractors designed and installed the system but the contract did not include the OEM data package. Without drawings or design knowledge, fixing the smallest of problems could turn into a multi-day project. In addition to high cost, as the OEM companies of proprietary parts went out of business, it became impossible to find a replacement for a failed part. These issues set the framework for the Pacer Comet 4 (PC4) system. PC4 was created as an organic AF and Department of Defense collaboration to fix the issues with PC3. PC4 provides the customer with a complete data package including multiple drawing sets and data sheets for all parts used, as well as design files for all PCBs created in house. PC4 has a standard to use commercially available off the shelf parts (COTS). The reason for this is sustainability in maintenance. If a part is to fail, it should be able to be purchased from any manufacturer that meets the specs of the original product. No proprietary parts are used, except as directed by the engine's OEM. This thesis will focus on the design and installation of the on-frame data acquisition PC4 system for the Pratt & Whitney TF33-P100A-QEC engine that is currently in use on the E3 Sentry. This thesis will show efficiency improvements for maintenance sustainability (70% cabling reduction) as well as discuss performance improvements in both test and production environments.

  9. Unusual Repertoire of Vocalizations in the BTBR T+tf/J Mouse Model of Autism

    PubMed Central

    Scattoni, Maria Luisa; Gandhy, Shruti U.; Ricceri, Laura; Crawley, Jacqueline N.

    2008-01-01

    BTBR T+ tf/J (BTBR) is an inbred mouse strain that displays social abnormalities and repetitive behaviors analogous to the first and third diagnostic symptoms of autism. Here we investigate ultrasonic vocalizations in BTBR, to address the second diagnostic symptom of autism, communication deficits. As compared to the commonly used C57BL/6J (B6) strain, BTBR pups called more loudly and more frequently when separated from their mothers and siblings. Detailed analysis of ten categories of calls revealed an unusual pattern in BTBR as compared to B6. BTBR emitted high levels of harmonics, two-syllable, and composite calls, but minimal numbers of chevron-shaped syllables, upward, downward, and short calls. Because body weights were higher in BTBR than B6 pups, one possible explanation was that larger thoracic size was responsible for the louder calls and different distribution of syllable categories. To test this possibility, we recorded separation calls from FVB/NJ, a strain with body weights similar to BTBR, and 129X1/SvJ, a strain with body weights similar to B6. BTBR remained the outlier on number of calls, displaying low numbers of complex, upward, chevron, short, and frequency steps calls, along with high harmonics and composites. Further, developmental milestones and growth rates were accelerated in BTBR, indicating an unusual neurodevelopmental trajectory. Overall, our findings demonstrate strain-specific patterns of ultrasonic calls that may represent different lexicons, or innate variations in complex vocal repertoires, in genetically distinct strains of mice. Particularly intriguing is the unusual pattern of vocalizations and the more frequent, loud harmonics evident in the BTBR mouse model of autism that may resemble the atypical vocalizations seen in some autistic infants. PMID:18728777

  10. Non-nuclear Testing of Reactor Systems in the Early Flight Fission Test Facilities (EFF-TF)

    NASA Technical Reports Server (NTRS)

    VanDyke, Melissa; Martin, James

    2004-01-01

    The Early Flight Fission-Test Facility (EFF-TF) can assist in the &sign and development of systems through highly effective non-nuclear testing of nuclear systems when technical issues associated with near-term space fission systems are "non-nuclear" in nature (e.g. system s nuclear operations are understood). For many systems. thermal simulators can he used to closely mimic fission heat deposition. Axial power profile, radial power profile. and fuel pin thermal conductivity can be matched. In addition to component and subsystem testing, operational and lifetime issues associated with the steady state and transient performance of the integrated reactor module can be investigated. Instrumentation at the EFF-TF allows accurate measurement of temperature, pressure, strain, and bulk core deformation (useful for accurately simulating nuclear behavior). Ongoing research at the EFF-TF is geared towards facilitating research, development, system integration, and system utilization via cooperative efforts with DOE laboratories, industry, universities, and other NASA centers. This paper describes the current efforts for the latter portion of 2003 and beginning of 2004.

  11. Columnar-Structured Thermal Barrier Coatings (TBCs) by Thin Film Low-Pressure Plasma Spraying (LPPS-TF)

    NASA Astrophysics Data System (ADS)

    Hospach, Andreas; Mauer, Georg; Vaßen, Robert; Stöver, Detlev

    2011-01-01

    The very low-pressure plasma Spray (VLPPS) process has been developed with the aim of depositing uniform and thin coatings with coverage of a large area by plasma spraying. At typical pressures of 100-200 Pa, the characteristics of the plasma jet change compared to conventional low-pressure plasma-spraying processes (LPPS) operating at 5-20 kPa. The combination of plasma spraying at low pressures with enhanced electrical input power has led to the development of the LPPS-TF process (TF = thin film). At appropriate parameters, it is possible to evaporate the powder feedstock material providing advanced microstructures of the deposits. This technique offers new possibilities for the manufacturing of thermal barrier coatings (TBCs). Besides the material composition, the microstructure is an important key to reduce thermal conductivity and to increase strain tolerance. In this regard, columnar microstructures deposited from the vapor phase show considerable advantages. Therefore, physical vapor deposition by electron beam evaporation (EB-PVD) is applied to achieve such columnar-structured TBCs. However, the deposition rate is low, and the line-of-sight nature of the process involves specific restrictions. In this article, the deposition of TBCs by the LPPS-TF process is shown. How the evaporation of the feedstock powder could be improved and to what extent the deposition rates could be increased were investigated.

  12. Early Flight Fission Test Facilities (EFF-TF) and Concepts That Support Near-Term Space Fission Missions

    NASA Technical Reports Server (NTRS)

    VanDyke, Melissa; Houts, Mike; Godfroy, Thomas; Martin, James

    2003-01-01

    Fission technology can enable rapid, affordable access to any point in the solar system. If fusion propulsion systems are to be developed to their full potential; however, near-term customers must be identified and initial fission systems successfully developed, launched, and utilized. Successful utilization will most likely occur if frequent, significant hardware-based milestones can be achieved throughout the program. If the system is designed to operate within established radiation damage and fuel burn up limits while simultaneously being designed to allow close simulation of heat from fission using resistance heaters, high confidence in fission system pe$ormance and lifetime can be attained through non-nuclear testing. Through demonstration of systems concepts (designed by DOE National Laboratories) in relevant environments, this philosophy has been demonstrated through hardware testing in the Early Flight Fission Test Facilities (EFF-TF) at the Marshall Space Flight Center. The EFF-TF is designed to enable very realistic non-nuclear testing of space fission systems. Ongoing research at the EFF-TF is geared towards facilitating research, development, system integration, and system utilization via cooperative efforts with DOE labs, industry, universities, and other NASA centers.

  13. On the connection between inherent DNA flexure and preferred binding of hydroxymethyluracil-containing DNA by the type II DNA-binding protein TF1.

    PubMed

    Grove, A; Galeone, A; Mayol, L; Geiduschek, E P

    1996-07-12

    TF1 is a member of the family of type II DNA-binding proteins, which also includes the bacterial HU proteins and the Escherichia coli integration host factor (IHF). Distinctive to TF1, which is encoded by the Bacillus subtilis bacteriophage SPO1, is its preferential binding to DNA in which thymine is replaced by 5-hydroxymethyluracil (hmU), as it is in the phage genome. TF1 binds to preferred sites within the phage genome and generates pronounced DNA bending. The extent to which DNA flexibility contributes to the sequence-specific binding of TF1, and the connection between hmU preference and DNA flexibility has been examined. Model flexible sites, consisting of consecutive mismatches, increase the affinity of thymine-containing DNA for TF1. In particular, tandem mismatches separated by nine base-pairs generate an increase, by orders of magnitude, in the affinity of TF1 for T-containing DNA with the sequence of a preferred TF1 binding site, and fully match the affinity of TF1 for this cognate site in hmU-containing DNA (Kd approximately 3 nM). Other placements of loops generate suboptimal binding. This is consistent with a significant contribution of site-specific DNA flexibility to complex formation. Analysis of complexes with hmU-DNA of decreasing length shows that a major part of the binding affinity is generated within a central 19 bp segment (delta G0 = 41.7 kJ mol-1) with more-distal DNA contributing modestly to the affinity (delta delta G = -0.42 kJ mol-1 bp-1 on increasing duplex length to 37 bp). However, a previously characterised thermostable and more tightly binding mutant TF1, TF1(E15G/T32I), derives most of its extra affinity from interaction with flanking DNA. We propose that inherent but sequence-dependent deformability of hmU-containing DNA underlies the preferential binding of TF1 and that TF1-induced DNA bendings is a result of distortions at two distinct sites separated by 9 bp of duplex DNA. PMID:8764400

  14. Jumping to conclusions and paranoid ideation in the general population.

    PubMed

    Freeman, Daniel; Pugh, Katherine; Garety, Philippa

    2008-07-01

    An association of a 'jumping to conclusions' (JTC) reasoning style and delusions has been repeatedly found. The data-gathering bias has been particularly implicated with higher levels of delusional conviction in schizophrenia. For the first time the symptom, psychological and social correlates of jumping to conclusions are examined in a large general population sample. This is based upon the recognition that delusional ideation in non-clinical populations is on a continuum of severity with delusions in psychosis. Two hundred individuals completed a probabilistic reasoning task and assessments of paranoid ideation, intellectual functioning, affective symptoms, anomalies of experience, cognitive flexibility, illicit drug use, social support, and trauma. The jumping to conclusions reasoning bias was found in 20% of the non-clinical sample. JTC was strongly associated with higher levels of conviction in paranoid thoughts and the occurrence of perceptual anomalies, but not with the presence of affective symptoms. The results indicate that jumping to conclusions is a reasoning bias specifically associated with levels of delusional conviction, and is not a product of generally high levels of distress and affect. The association of jumping to conclusions with the types of anomalies of experience seen in psychotic disorders is intriguing, and consistent with recent dopamine dysregulation theories and the importance of reasoning to perception. The study is a further illustration of the need to consider the dimensions of delusional experience separately. PMID:18442898

  15. 39 CFR 954.18 - Proposed findings and conclusions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 39 Postal Service 1 2014-07-01 2014-07-01 false Proposed findings and conclusions. 954.18 Section 954.18 Postal Service UNITED STATES POSTAL SERVICE PROCEDURES RULES OF PRACTICE IN PROCEEDINGS RELATIVE TO THE DENIAL, SUSPENSION, OR REVOCATION OF PERIODICALS MAIL PRIVILEGES § 954.18 Proposed...

  16. 39 CFR 954.18 - Proposed findings and conclusions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 39 Postal Service 1 2013-07-01 2013-07-01 false Proposed findings and conclusions. 954.18 Section 954.18 Postal Service UNITED STATES POSTAL SERVICE PROCEDURES RULES OF PRACTICE IN PROCEEDINGS RELATIVE TO THE DENIAL, SUSPENSION, OR REVOCATION OF PERIODICALS MAIL PRIVILEGES § 954.18 Proposed...

  17. 39 CFR 954.18 - Proposed findings and conclusions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Proposed findings and conclusions. 954.18 Section 954.18 Postal Service UNITED STATES POSTAL SERVICE PROCEDURES RULES OF PRACTICE IN PROCEEDINGS RELATIVE TO THE DENIAL, SUSPENSION, OR REVOCATION OF PERIODICALS MAIL PRIVILEGES § 954.18 Proposed...

  18. 39 CFR 954.18 - Proposed findings and conclusions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 39 Postal Service 1 2012-07-01 2012-07-01 false Proposed findings and conclusions. 954.18 Section 954.18 Postal Service UNITED STATES POSTAL SERVICE PROCEDURES RULES OF PRACTICE IN PROCEEDINGS RELATIVE TO THE DENIAL, SUSPENSION, OR REVOCATION OF PERIODICALS MAIL PRIVILEGES § 954.18 Proposed...

  19. 39 CFR 954.18 - Proposed findings and conclusions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 39 Postal Service 1 2011-07-01 2011-07-01 false Proposed findings and conclusions. 954.18 Section 954.18 Postal Service UNITED STATES POSTAL SERVICE PROCEDURES RULES OF PRACTICE IN PROCEEDINGS RELATIVE TO THE DENIAL, SUSPENSION, OR REVOCATION OF PERIODICALS MAIL PRIVILEGES § 954.18 Proposed...

  20. Hypothesis, Prediction, and Conclusion: Using Nature of Science Terminology Correctly

    ERIC Educational Resources Information Center

    Eastwell, Peter

    2012-01-01

    This paper defines the terms "hypothesis," "prediction," and "conclusion" and shows how to use the terms correctly in scientific investigations in both the school and science education research contexts. The scientific method, or hypothetico-deductive (HD) approach, is described and it is argued that an understanding of the scientific method,…

  1. Consultation on Higher Education and Social Justice: Statement and Conclusions

    ERIC Educational Resources Information Center

    New Frontiers in Education, 1974

    1974-01-01

    A group of 35 educators, mostly principals and teachers of colleges, met at Bangalore, India in May 1974 for a 5-day consultation on higher education's role in the promotion of social justice. The final statement and other conclusions of the Consultation are presented. (Author/PG)

  2. 22 CFR 18.18 - Proposed findings and conclusions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Proposed findings and conclusions. 18.18 Section 18.18 Foreign Relations DEPARTMENT OF STATE PERSONNEL REGULATIONS CONCERNING POST EMPLOYMENT CONFLICT OF INTEREST Administrative Enforcement Proceedings § 18.18 Proposed findings and...

  3. Safety Specialist Manpower Conclusions and Recommendations, Volume IV.

    ERIC Educational Resources Information Center

    Booz Allen and Hamilton, Inc., Washington, DC.

    This final volume of a four-volume report on highway safety manpower includes conclusions and recommendations regarding prospects for staffing individual programs, with emphasis on the adequacy of both manpower resources and training capacity. The data indicate that reaching maximum staffing levels by 1977 is unlikely, although minimum levels…

  4. 40 CFR 22.26 - Proposed findings, conclusions, and order.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Proposed findings, conclusions, and order. 22.26 Section 22.26 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL CONSOLIDATED RULES OF PRACTICE GOVERNING THE ADMINISTRATIVE ASSESSMENT OF CIVIL PENALTIES AND THE REVOCATION/TERMINATION OR SUSPENSION OF PERMITS...

  5. 40 CFR 22.26 - Proposed findings, conclusions, and order.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Proposed findings, conclusions, and order. 22.26 Section 22.26 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL CONSOLIDATED RULES OF PRACTICE GOVERNING THE ADMINISTRATIVE ASSESSMENT OF CIVIL PENALTIES AND THE REVOCATION/TERMINATION OR SUSPENSION OF PERMITS...

  6. Personality disorders

    MedlinePlus

    ... this page: //medlineplus.gov/ency/article/000939.htm Personality disorders To use the sharing features on this page, please enable JavaScript. Personality disorders are a group of mental conditions in ...

  7. Personality Disorders

    MedlinePlus

    Personality disorders are a group of mental illnesses. They involve long-term patterns of thoughts and behaviors ... serious problems with relationships and work. People with personality disorders have trouble dealing with everyday stresses and ...

  8. Personality Disorders

    MedlinePlus

    Personality disorders are a group of mental illnesses. They involve long-term patterns of thoughts and behaviors that ... serious problems with relationships and work. People with personality disorders have trouble dealing with everyday stresses and problems. ...

  9. 2015 Southern Taurid fireballs and asteroids 2005 UR and 2005 TF50

    NASA Astrophysics Data System (ADS)

    Olech, A.; Żołądek, P.; Wiśniewski, M.; Rudawska, R.; Bęben, M.; Krzyżanowski, T.; Myszkiewicz, M.; Stolarz, M.; Gawroński, M.; Gozdalski, M.; Suchodolski, T.; Węgrzyk, W.; Tymiński, Z.

    2016-09-01

    On the night of October 31, 2015 two bright Southern Taurid fireballs occurred over Poland, being one of the most spectacular bolides of this shower in recent years. The first fireball - PF311015a Okonek - was detected by six video stations of Polish Fireball Network (PFN) and photographed by several bystanders, allowing for precise determination of the trajectory and orbit of the event. The PF311015a Okonek entered Earth's atmosphere with the velocity of 33.2 ± 0.1 km s-1 and started to shine at height of 117.88 ± 0.05 km. The maximum brightness of -16.0 ± 0.4 mag was reached at height of 82.5 ± 0.1 km. The trajectory of the fireball ended at height of 60.2 ± 0.2 km with terminal velocity of 30.2 ± 1.0 km s-1. The second fireball - PF311015b Ostrowite - was detected by six video stations of PFN. It started with velocity of 33.2 ± 0.1 km s-1 at height of 108.05 ± 0.02 km. The peak brightness of -14.8 ± 0.5 mag was recorded at height of 82.2 ± 0.1 km. The terminal velocity was 31.8 ± 0.5 km s-1 and was observed at height of 57.86 ± 0.03 km. The orbits of both fireballs are similar not only to orbits of Southern Taurids and comet 2P/Encke, but even closer resemblance was noticed for orbits of 2005 UR and 2005 TF50 asteroids. Especially the former object is interesting because of its close flyby during spectacular Taurid maximum in 2005. We carried out a further search to investigate the possible genetic relationship of Okonek and Ostrowite fireballs with both asteroids, that are considered to be associated with Taurid complex. Although, we could not have confirmed unequivocally the relation between fireballs and these objects, we showed that both asteroids could be associated, having the same origin in a disruption process that separates them.

  10. Development of uncertainty methodology for COBRA-TF void distribution and critical power predictions

    NASA Astrophysics Data System (ADS)

    Aydogan, Fatih

    specimens among the sample with a bias lower than the experimental uncertainty. Besides, the rankings of dominant phenomena are observed with the second comparison method (sensitivity analysis). Simple Random Sampling, Order Statistics, Richardson Extrapolation are some of the methods that are in the developed methodology. This uncertainty methodology was implemented for the COBRA-TF predictions. The uncertainty and sensitivity results are presented in the dissertation.

  11. 2015 Southern Taurid fireballs and asteroids 2005 UR and 2005 TF50

    NASA Astrophysics Data System (ADS)

    Olech, A.; Żołądek, P.; Wiśniewski, M.; Rudawska, R.; Bęben, M.; Krzyżanowski, T.; Myszkiewicz, M.; Stolarz, M.; Gawroński, M.; Gozdalski, M.; Suchodolski, T.; Węgrzyk, W.; Tymiński, Z.

    2016-05-01

    On the night of Oct 31, 2015 two bright Southern Taurid fireballs occurred over Poland, being one of the most spectacular bolides of this shower in recent years. The first fireball - PF311015a Okonek - was detected by six video stations of Polish Fireball Network (PFN) and photographed by several bystanders, allowing for precise determination of the trajectory and orbit of the event. The PF311015a Okonek entered Earth's atmosphere with the velocity of 33.2 ± 0.1 km/s and started to shine at height of 117.88 ± 0.05 km. The maximum brightness of -16.0 ± 0.4 mag was reached at height of 82.5 ± 0.1 km. The trajectory of the fireball ended at height of 60.2 ± 0.2 km with terminal velocity of 30.2 ± 1.0 km/s. The second fireball - PF311015b Ostrowite - was detected by six video stations of PFN. It started with velocity of 33.2 ± 0.1 km/s at height of 108.05 ± 0.02 km. The peak brightness of -14.8 ± 0.5 mag was recorded at height of 82.2 ± 0.1 km. The terminal velocity was 31.8 ± 0.5 km/s and was observed at height of 57.86 ± 0.03 km. The orbits of both fireballs are similar not only to orbits of Southern Taurids and comet 2P/Encke, but even closer resemblance was noticed for orbits of 2005 UR and 2005 TF50 asteroids. Especially the former object is interesting because of its close flyby during spectacular Taurid maximum in 2005. We carried out a further search to investigate the possible genetic relationship of Okonek and Ostrowite fireballs with both asteroids, that are considered to be associated with Taurid complex. Although, we could not have confirmed unequivocally the relation between fireballs and these objects, we showed that both asteroids could be associated, having the same origin in a disruption process that separates them.

  12. Statistical Conclusion Validity: Some Common Threats and Simple Remedies

    PubMed Central

    García-Pérez, Miguel A.

    2012-01-01

    The ultimate goal of research is to produce dependable knowledge or to provide the evidence that may guide practical decisions. Statistical conclusion validity (SCV) holds when the conclusions of a research study are founded on an adequate analysis of the data, generally meaning that adequate statistical methods are used whose small-sample behavior is accurate, besides being logically capable of providing an answer to the research question. Compared to the three other traditional aspects of research validity (external validity, internal validity, and construct validity), interest in SCV has recently grown on evidence that inadequate data analyses are sometimes carried out which yield conclusions that a proper analysis of the data would not have supported. This paper discusses evidence of three common threats to SCV that arise from widespread recommendations or practices in data analysis, namely, the use of repeated testing and optional stopping without control of Type-I error rates, the recommendation to check the assumptions of statistical tests, and the use of regression whenever a bivariate relation or the equivalence between two variables is studied. For each of these threats, examples are presented and alternative practices that safeguard SCV are discussed. Educational and editorial changes that may improve the SCV of published research are also discussed. PMID:22952465

  13. Pregnancy-associated plasma protein-A promotes TF procoagulant activity in human endothelial cells by Akt-NF-κB axis.

    PubMed

    Cirillo, Plinio; Conte, Stefano; Pellegrino, Grazia; Ziviello, Francesca; Barra, Giusi; De Palma, Raffaele; Leonardi, Antonio; Trimarco, Bruno

    2016-08-01

    Pregnancy-associated plasma protein-A (PAPP-A) is a metalloproteinase with a controversial role in pathophysiology of cardiovascular disease. It seems involved in progression of atherosclerosis and is widely represented in atherosclerotic plaque. PAPP-A plasma levels are elevated in patients with acute coronary syndromes (ACS), thus it has been suggested that it might be a prognostic marker for developing major cardiovascular events. However, the pathophysiological link(s) between PAPP-A and ACS are still unknown. Several studies have indicated that tissue factor (TF) plays a pivotal role in the pathophysiology of ACS by triggering the formation of intracoronary thrombi following endothelial injury. This study investigates whether PAPP-A, at concentrations measurable in ACS patients, might induce TF expression in human endothelial cells in culture (HUVEC). In HUVEC, PAPP-A induced TF-mRNA transcription as demonstrated by real time PCR and expression of functionally active TF as demonstrated by FACS analysis and pro-coagulant activity assay. PAPP-A induced TF expression through the activation of Akt/NF-κB axis, as demonstrated by luciferase assay and by suppression of TF-mRNA transcription as well as of TF expression/activity by Akt and NF-κB inhibitors. These data indicate that PAPP-A promotes TF expression in human endothelial cells and support the hypothesis that this proteinase, besides being involved in progression of atherosclerosis, does not represent an independent risk factor for adverse cardiovascular events, but it rather might play an "active" role in the pathophysiology of ACS as an effector molecule able to induce a pro-thrombotic phenotype in endothelial cells. PMID:27007282

  14. Draft Genome Sequence of Bacillus marisflavi TF-11T (JCM 11544), a Carotenoid-Producing Bacterium Isolated from Seawater from a Tidal Flat in the Yellow Sea

    PubMed Central

    Wang, Jie-ping; Liu, Guo-hong; Chen, De-ju; Chen, Qian-qian; Zhu, Yu-jing; Chen, Zheng; Che, Jian-mei

    2015-01-01

    Bacillus marisflavi TF-11T (JCM 11544) is a Gram-positive, spore-forming, and carotenoid-producing bacterium isolated from seawater from a tidal flat in the Yellow Sea. Here, we report the first draft genome sequence of B. marisflavi TF-11T, which comprises 4.31 Mb in 11 scaffolds with a G+C content of 48.57%. PMID:26659687

  15. Improvement of COBRA-TF for modeling of PWR cold- and hot-legs during reactor transients

    NASA Astrophysics Data System (ADS)

    Salko, Robert K.

    COBRA-TF is a two-phase, three-field (liquid, vapor, droplets) thermal-hydraulic modeling tool that has been developed by the Pacific Northwest Laboratory under sponsorship of the NRC. The code was developed for Light Water Reactor analysis starting in the 1980s; however, its development has continued to this current time. COBRA-TF still finds wide-spread use throughout the nuclear engineering field, including nuclear-power vendors, academia, and research institutions. It has been proposed that extension of the COBRA-TF code-modeling region from vessel-only components to Pressurized Water Reactor (PWR) coolant-line regions can lead to improved Loss-of-Coolant Accident (LOCA) analysis. Improved modeling is anticipated due to COBRA-TF's capability to independently model the entrained-droplet flow-field behavior, which has been observed to impact delivery to the core region[1]. Because COBRA-TF was originally developed for vertically-dominated, in-vessel, sub-channel flow, extension of the COBRA-TF modeling region to the horizontal-pipe geometries of the coolant-lines required several code modifications, including: • Inclusion of the stratified flow regime into the COBRA-TF flow regime map, along with associated interfacial drag, wall drag and interfacial heat transfer correlations, • Inclusion of a horizontal-stratification force between adjacent mesh cells having unequal levels of stratified flow, and • Generation of a new code-input interface for the modeling of coolant-lines. The sheer number of COBRA-TF modifications that were required to complete this work turned this project into a code-development project as much as it was a study of thermal-hydraulics in reactor coolant-lines. The means for achieving these tasks shifted along the way, ultimately leading the development of a separate, nearly completely independent one-dimensional, two-phase-flow modeling code geared toward reactor coolant-line analysis. This developed code has been named CLAP, for

  16. Improvement of COBRA-TF for modeling of PWR cold- and hot-legs during reactor transients

    NASA Astrophysics Data System (ADS)

    Salko, Robert K.

    COBRA-TF is a two-phase, three-field (liquid, vapor, droplets) thermal-hydraulic modeling tool that has been developed by the Pacific Northwest Laboratory under sponsorship of the NRC. The code was developed for Light Water Reactor analysis starting in the 1980s; however, its development has continued to this current time. COBRA-TF still finds wide-spread use throughout the nuclear engineering field, including nuclear-power vendors, academia, and research institutions. It has been proposed that extension of the COBRA-TF code-modeling region from vessel-only components to Pressurized Water Reactor (PWR) coolant-line regions can lead to improved Loss-of-Coolant Accident (LOCA) analysis. Improved modeling is anticipated due to COBRA-TF's capability to independently model the entrained-droplet flow-field behavior, which has been observed to impact delivery to the core region[1]. Because COBRA-TF was originally developed for vertically-dominated, in-vessel, sub-channel flow, extension of the COBRA-TF modeling region to the horizontal-pipe geometries of the coolant-lines required several code modifications, including: • Inclusion of the stratified flow regime into the COBRA-TF flow regime map, along with associated interfacial drag, wall drag and interfacial heat transfer correlations, • Inclusion of a horizontal-stratification force between adjacent mesh cells having unequal levels of stratified flow, and • Generation of a new code-input interface for the modeling of coolant-lines. The sheer number of COBRA-TF modifications that were required to complete this work turned this project into a code-development project as much as it was a study of thermal-hydraulics in reactor coolant-lines. The means for achieving these tasks shifted along the way, ultimately leading the development of a separate, nearly completely independent one-dimensional, two-phase-flow modeling code geared toward reactor coolant-line analysis. This developed code has been named CLAP, for

  17. Shaping ability of Reciproc and TF Adaptive systems in severely curved canals of rapid microCT-based prototyping molar replicas

    PubMed Central

    ORDINOLA-ZAPATA, Ronald; BRAMANTE, Clovis Monteiro; DUARTE, Marco Antonio Húngaro; CAVENAGO, Bruno Cavalini; JARAMILLO, David; VERSIANI, Marco Aurélio

    2014-01-01

    Objective: To evaluate the shaping ability of Reciproc and Twisted-File Adaptive systems in rapid prototyping replicas. Material and Methods: Two mandibular molars showing S-shaped and 62-degree curvatures in the mesial root were scanned by using a microcomputed tomography (μCT) system. The data were exported in the stereolitograhic format and 20 samples of each molar were printed at 16 µm resolution. The mesial canals of 10 replicas of each specimen were prepared with each system. Transportation was measured by overlapping radiographs taken before and after preparation and resin thickness after instrumentation was measured by μCT. Results: Both systems maintained the original shape of the apical third in both anatomies (P>0.05). Overall, considering the resin thickness in the 62-degree replicas, no statistical difference was found between the systems (P>0.05). In the S-shaped curvature replica, Reciproc significantly decreased the thickness of the resin walls in comparison with TF Adaptive. Conclusions: The evaluated systems were able to maintain the original shape at the apical third of severely curved mesial canals of molar replicas. PMID:24918662

  18. Enhancement of Short-Term Memory by Methyl-6-(Phenylethynyl)-Pyridine in the BTBR T+tf/J Mouse Model of Autism Spectrum Disorder

    PubMed Central

    Yang, Haijie; Huh, Sung-Oh

    2015-01-01

    Background Autism spectrum disorder (ASD) encompasses a range of disorders that are characterized by social and communication deficits and repetitive behaviors. This study evaluated the effect of methyl-6-(phenylethynyl)-pyridine (MPEP), an antagonist of the mGluR5 metabotropic glutamate receptor, on memory enhancement in the BTBR T+tf/J (BTBR) mouse strain, which has been recognized as a model of ASD. Methods The pharmacological effects of MPEP on memory and motor coordination were assessed using the Morris water maze and rotarod tests in BTBR and C57BL/6J (B6) mice. Furthermore, we performed morphological analyses of cerebellar foliation in BTBR and B6 mice using hematoxylin and eosin staining. Results MPEP-treated BTBR mice exhibited improved learning and memory in the Morris water maze test. MPEP administration also improved motor coordination in the rotarod test. However, no significant difference was observed regarding the numbers of Purkinje cells in the cerebella of BTBR versus normal B6 mice. Conclusion This study suggests that the mGluR5 antagonist MPEP has the potential to ameliorate learning and memory dysfunction and impaired motor coordination in BTBR mice. These results further suggest that the BTBR mouse model may be useful in pharmacological studies investigating drugs that could potentially alleviate cognitive dysfunction in ASD. PMID:25559718

  19. Generalized measurement and conclusive teleportation with nonmaximal entanglement

    SciTech Connect

    Kim, Hyunjae; Cheong, Yong Wook; Lee, Hai-Woong

    2004-07-01

    We present linear optical schemes to perform generalized measurements for conclusive teleportation when the sender and the receiver share nonmaximal entanglement resulting from amplitude errors during propagation or generation. Three different cases are considered for which the states to be teleported are unknown superpositions of (a) single-photon and vacuum states (b) vertically polarized and horizontally polarized photon states, and (c) two coherent states of opposite phases. The generalized measurement scheme for each case is analyzed, which indicates that the success probability is much more resistant to amplitude errors for case (c) than for case (a) or (b)

  20. Workshop observations, conclusions, and recommendations for moving forward

    SciTech Connect

    1995-12-31

    Bangkok currently has enormous numbers of motorised vehicles. The number of motor vehicles registered in Bangkok in 1993 was about 2.6 million of which over 1 million were cars and around 1.1 million were motorcycles. The vehicle population is noticeably increasing at about 12% over the previous year, despite the traffic congestion which is nearly at gridlock. Overall average traffic speed in the Bangkok metropolitan area is around 10 km/h. However, during peak hours on some main roads in the central business area, the crawl rate is at 1-2 km/h, or only half walking pace. There are, however, several circumstances to be addressed before Bangkok can begin to overcome its air quality and congestion problems. The first is that many of the city`s transport planners that design transport projects, and the policymakers with investment authority appear to be caught in the same conventional transport planning paradigm as many other industrializing and industrialized countries. That paradigm, pioneered in the United States and exported to much of the world, defines the problems as a shortage of road space to meet demand for, private, vehicular mobility. The investment focus is almost exclusively on the construction of large road-based infrastructure to machines instead of people, while de-emphasizing other forms of transport such as rail, water, and non-motorized transport - even if they are a less expensive investment that can meet demand. The predominance of this paradigm results in a persistent myth held by many of Bangkok`s policymakers, transport and urban planners, financiers, and citizens. The myth is that the city does not have enough kilometers of roadways per person, and should focus on road and highway investment in order to solve their air quality and congestion problems.

  1. Separation of carbon dioxide and sulfur dioxide gases using room-temperature ionic liquid (hmim)(Tf2N)

    SciTech Connect

    A. Yokozeki; Mark B. Shiflett

    2009-09-15

    To understand capturing and/or enhanced gaseous selectivity of industrial flue gases containing CO{sub 2} and SO{sub 2} using room-temperature ionic liquids, we have developed a ternary equation of state (EOS) model for a CO{sub 2}/SO{sub 2}/1-hexyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide ((hmim)(Tf2N)) system. The present model is based on a generic RK (Redlich-Kwong) EOS, with empirical binary interaction parameters of each binary system. These interaction parameters have been determined using our measured VLE (vapor-liquid-equilibrium) data for SO{sub 2}/(hmim)(Tf2N) and CO{sub 2}/(hmim)(Tf2N) and literature data for CO{sub 2}/SO{sub 2}. The validity of the present EOS has been checked by conducting ternary VLE experiments for the present system. With this EOS, isothermal ternary phase diagrams and solubility (VLE) behaviors have been calculated for various (T, P, and feed compositions) conditions. For large and equimolar CO{sub 2}/SO{sub 2} mole ratios, the gaseous selectivity is nearly independent of the amount of the ionic liquid addition. However, for small CO{sub 2}/SO{sub 2} mole ratios the addition of the ionic liquid significantly increases the selectivity. The strong absorption of CO{sub 2} and SO{sub 2} in this ionic liquid may be practical for the simultaneous capture of these acid gases. 39 refs., 8 figs., 4 tabs.

  2. Conclusive quantum steering with superconducting transition edge sensors

    NASA Astrophysics Data System (ADS)

    de Almeida, Marcelo P.; Smith, Devin H.; Gillett, Geo; Branciard, Cyril; Fedrizzi, Alessandro; Weinhold, Till J.; Lita, Adriana; Calkins, Brice; Gertis, Thomas; Nam, Sae Woo; White, Andrew G.

    2012-02-01

    Quantum steering allows two parties to verify shared entanglement even if one measurement device is untrusted. A conclusive demonstration of steering through the violation of a steering inequality is of considerable fundamental interest and opens up applications in quantum communication. To date all experimental tests with single photon states have relied on post-selection, allowing untrusted devices to cheat by hiding unfavorable events in losses. Here we close this ``detection loophole'' by combining a highly efficient source of entangled photon pairs with superconducting transition edge sensors. We achieve an unprecedented ˜62% conditional detection efficiency of entangled photons and violate a steering inequality with the minimal number of measurement settings by 48 standard deviations. Our results provide a clear path to practical applications of steering and to a photonic loophole-free Bell test.

  3. Conclusive quantum steering with superconducting transition-edge sensors

    NASA Astrophysics Data System (ADS)

    Smith, Devin H.; Gillett, Geoff; de Almeida, Marcelo P.; Branciard, Cyril; Fedrizzi, Alessandro; Weinhold, Till J.; Lita, Adriana; Calkins, Brice; Gerrits, Thomas; Wiseman, Howard M.; Nam, Sae Woo; White, Andrew G.

    2012-01-01

    Quantum steering allows two parties to verify shared entanglement even if one measurement device is untrusted. A conclusive demonstration of steering through the violation of a steering inequality is of considerable fundamental interest and opens up applications in quantum communication. To date, all experimental tests with single-photon states have relied on post selection, allowing untrusted devices to cheat by hiding unfavourable events in losses. Here we close this 'detection loophole' by combining a highly efficient source of entangled photon pairs with superconducting transition-edge sensors. We achieve an unprecedented ~62% conditional detection efficiency of entangled photons and violate a steering inequality with the minimal number of measurement settings by 48 s.d.s. Our results provide a clear path to practical applications of steering and to a photonic loophole-free Bell test.

  4. Parenteral trace element provision: recent clinical research and practical conclusions.

    PubMed

    Stehle, P; Stoffel-Wagner, B; Kuhn, K S

    2016-08-01

    The aim of this systematic review (PubMed, www.ncbi.nlm.nih.gov/pubmed and Cochrane, www.cochrane.org; last entry 31 December 2014) was to present data from recent clinical studies investigating parenteral trace element provision in adult patients and to draw conclusions for clinical practice. Important physiological functions in human metabolism are known for nine trace elements: selenium, zinc, copper, manganese, chromium, iron, molybdenum, iodine and fluoride. Lack of, or an insufficient supply of, these trace elements in nutrition therapy over a prolonged period is associated with trace element deprivation, which may lead to a deterioration of existing clinical symptoms and/or the development of characteristic malnutrition syndromes. Therefore, all parenteral nutrition prescriptions should include a daily dose of trace elements. To avoid trace element deprivation or imbalances, physiological doses are recommended. PMID:27049031

  5. Development of burnup dependent fuel rod model in COBRA-TF

    NASA Astrophysics Data System (ADS)

    Yilmaz, Mine Ozdemir

    The purpose of this research was to develop a burnup dependent fuel thermal conductivity model within Pennsylvania State University, Reactor Dynamics and Fuel Management Group (RDFMG) version of the subchannel thermal-hydraulics code COBRA-TF (CTF). The model takes into account first, the degradation of fuel thermal conductivity with high burnup; and second, the fuel thermal conductivity dependence on the Gadolinium content for both UO2 and MOX fuel rods. The modified Nuclear Fuel Industries (NFI) model for UO2 fuel rods and Duriez/Modified NFI Model for MOX fuel rods were incorporated into CTF and fuel centerline predictions were compared against Halden experimental test data and FRAPCON-3.4 predictions to validate the burnup dependent fuel thermal conductivity model in CTF. Experimental test cases from Halden reactor fuel rods for UO2 fuel rods at Beginning of Life (BOL), through lifetime without Gd2O3 and through lifetime with Gd 2O3 and a MOX fuel rod were simulated with CTF. Since test fuel rod and FRAPCON-3.4 results were based on single rod measurements, CTF was run for a single fuel rod surrounded with a single channel configuration. Input decks for CTF were developed for one fuel rod located at the center of a subchannel (rod-centered subchannel approach). Fuel centerline temperatures predicted by CTF were compared against the measurements from Halden experimental test data and the predictions from FRAPCON-3.4. After implementing the new fuel thermal conductivity model in CTF and validating the model with experimental data, CTF model was applied to steady state and transient calculations. 4x4 PWR fuel bundle configuration from Purdue MOX benchmark was used to apply the new model for steady state and transient calculations. First, one of each high burnup UO2 and MOX fuel rods from 4x4 matrix were selected to carry out single fuel rod calculations and fuel centerline temperatures predicted by CTF/TORT-TD were compared against CTF /TORT-TD /FRAPTRAN

  6. Formation and emission of nitrogen oxide in gas turbine engines: plume effluent characteristics of TF3O-P111+ and TF33-P9 engines. Final technical report, 1 November-17 December 1993

    SciTech Connect

    Dill, J.W.; Sowa, W.A.; Samuelsen, G.S.

    1996-06-30

    Phase I of this project focused on the creation of a spatial emissions map of the plume effluent in the exhaust stream directly behind the engine in a jet engine test cell (JETC). Both afterburning TF30-P111+ and non-after-burning TF33-P9 engines were tested. Measurements were taken in conjunction with actual engine tests for validity of the data. Temperature, oxides of nitrogen (NOx), carbon monoxide (CO) concentration, and velocity were among the characteristics measured radially and axially in the plume for each engine type. The main focus of this study was on NOx, consisting of nitric oxide (NO) and nitrogen dioxide (NO2). Measurements in the P111+ plume reveal levels of NOx above 300 ppm along the centerline of the effluent. A dip in the NOx emissions at afterburner shows signs of a reburning and/or dilution effect by the atmospheric combustion in the effluent. Significant amounts of NO2 are present in the effluent over the entire power range. Temperatures at military power reach 1100 deg F along the centerline, and CO values are below 80 ppm. Carbon monoxide concentrations decrease from idle to military power (full power, no afterburner), then rise sharply in afterburner. The CO peaks shift outward from centerline as do the temperatures due to the radial geometry of the afterburner combustion (over 10 percent CO at 2850 deg F).

  7. Differences between evolution of Titan's and Earth's rivers - further conclusions

    NASA Astrophysics Data System (ADS)

    Misiura, Katarzyna; Czechowski, Leszek

    2014-05-01

    Titan is the only celestial body, beside the Earth, where liquid is present on the surface. Liquid forms a number of lakes and rivers. In our research we use numerical model of the river to determine differences of evolution of rivers on the Earth and on Titan. We have found that transport of sediments on Titan is more effective than on Earth for the same river geometry and discharge. We have found also the theoretical explanations for this conclusion. 2.Introduction Titan is a very special body in the Solar System. It is the only moon that has dense atmosphere and flowing liquid on its surface. The Cassini-Huygens mission has found on Titan meandering rivers, and indicated processes of erosion, transport of solid material and its sedimentation. This paper is aimed to investigate the similarity and differences between these processes on Titan and the Earth. 3. Basic equations of our model The dynamical analysis of the considered rivers is performed using the package CCHE modified for the specific conditions on Titan. The package is based on the Navier-Stokes equations for depth-integrated two dimensional, turbulent flow and three dimensional convection-diffusion equation of sediment transport. 4. Parameters of the model We considered our model for a few kinds of liquid found on Titan. The liquid that falls as a rain (75% methane, 25% nitrogen) has different properties than the fluid forming lakes (74% ethane, 10% methane, 7% propane, 8.5% butane, 0.5% nitrogen). Other parameters of our model are: inflow discharge, outflow level, grain size of sediments etc. For every calculation performed for Titan's river similar calculations are performed for terrestrial ones. 5. Results and Conclusions The results of our simulation show the differences in behaviour of the flow and of sedimentation on Titan and on the Earth. Our preliminary results indicate that transport of material by Titan's rivers is more efficient than by terrestrial rivers of the same geometry parameters

  8. Direct demonstration of increased expression of Thomsen-Friedenreich (TF) antigen in colonic adenocarcinoma and ulcerative colitis mucin and its concealment in normal mucin.

    PubMed Central

    Campbell, B J; Finnie, I A; Hounsell, E F; Rhodes, J M

    1995-01-01

    Increased binding of the lectin peanut agglutinin is a common feature in epithelial malignancy and hyperplasia. This may have considerable functional importance in the intestine by allowing interaction between the epithelium and mitogenic lectins of dietary or microbial origin. Peanut agglutinin binds the disaccharide Thomsen-Friedenreich (TF, T or core 1) blood group antigen, Gal beta (1-3) GalNAc alpha-, but is not totally specific for this site. Consequently, there has been controversy about the presence of this structure in colon cancer; studies with anti-TF monoclonal antibodies have failed to detect it. We have examined the presence of TF antigen in colonic mucus glycoprotein (mucin) using endo-alpha-N-acetylgalactosaminidase (O-Glycanase), which specifically catalyzes the hydrolysis of TF antigen from glycoconjugates. Samples of adenocarcinoma, inflammatory bowel disease (ulcerative colitis), and normal mucin were treated with O-glycanase, the liberated disaccharide was separated from the glycoprotein and analyzed using dual CarboPac PA-100 column high performance anion-exchange chromatography coupled with pulsed amperometric detection. O-Glycanase treatment released increased amounts of TF antigen from both colonic adenocarcinoma (8.0 +/- 3.9 ng/micrograms protein, n = 11; P < 0.0001 ANOVA) and ulcerative colitis mucin (3.3 +/- 0.3 ng/micrograms protein, n = 5; P = 0.04) compared with mucin samples from histologically normal mucosa distant from carcinoma (1.5 +/- 1.1 ng/micrograms protein, n = 9). However, after mild acid treatment to remove sialic acids and fucose, releasable TF antigen was increased in all nine of these histologically normal mucin samples (5.5 +/- 2.6 ng/micrograms protein, P < 0.0002). We conclude that TF antigen is an oncofetal antigen which is expressed in colon cancer, but is concealed by further glycosylation (sialylation and/or fucosylation) in the normal colonic mucosa. PMID:7860740

  9. Differences in BTBR T+ tf/J and C57BL/6J mice on probabilistic reversal learning and stereotyped behaviors

    PubMed Central

    Amodeo, Dionisio A.; Jones, Joshua H.; Sweeney, John A.; Ragozzino, Michael E.

    2011-01-01

    Autism spectrum disorders (ASD) represent a class of neurodevelopmental disorders characterized by impairments in social interaction, verbal and non-verbal communication, as well as restricted interests and repetitive behavior. This latter class of symptoms often includes features such as compulsive behaviors and resistance to change. The BTBR T+tf/J mouse strain has been used as an animal model to investigate the social communication and restricted interest features in ASD. Less is known about whether this mouse strain models cognitive flexibility deficits also observed in ASD. The present experiment investigated performance of BTBR T+tf/J and C57BL/6J on two different spatial reversal learning tests (100% accurate feedback and 80/20 probabilistic feedback), as well as marble burying and grooming behavior. BTBR T+tf/J and C57BL/6J mice exhibited similar performance on acquisition and reversal learning with 100% accurate feedback. BTBR T+tf/J mice were impaired in probabilistic reversal learning compared to that of C57BL/6J mice. BTBR T+tf/J mice also displayed increased stereotyped repetitive behaviors compared to that of C57BL/6J mice as shown by increased marble burying and grooming behavior. The present findings indicate that BTBR T+tf/J mice exhibit similar features related to “insistence on sameness” in ASD that include not only stereotyped repetitive behaviors, but also alterations in behavioral flexibility. Thus, BTBR T+tf/J mice can serve as a model to understand the neural mechanisms underlying alterations in behavioral flexibility, as well as to test potential treatments in alleviating these symptoms. PMID:22056750

  10. Scale decisions can reverse conclusions on community assembly processes

    PubMed Central

    Münkemüller, Tamara; Gallien, Laure; Lavergne, Sébastien; Renaud, Julien; Roquet, Cristina; Abdulhak, Sylvain; Dullinger, Stefan; Garraud, Luc; Guisan, Antoine; Lenoir, Jonathan; Svenning, Jens-Christian; Van Es, Jérémie; Vittoz, Pascal; Willner, Wolfgang; Wohlgemuth, Thomas; Zimmermann, Niklaus E.; Thuiller, Wilfried

    2014-01-01

    Aim Phylogenetic diversity patterns are increasingly being used to better understand the role of ecological and evolutionary processes in community assembly. Here, we quantify how these patterns are influenced by scale choices in terms of spatial and environmental extent and organismic scales. Location European Alps. Methods We applied 42 sampling strategies differing in their combination of focal scales. For each resulting sub-dataset, we estimated the phylogenetic diversity of the species pools, phylogenetic α-diversities of local communities, and statistics commonly used together with null models in order to infer non-random diversity patterns (i.e. phylogenetic clustering versus over-dispersion). Finally, we studied the effects of scale choices on these measures using regression analyses. Results Scale choices were decisive for revealing signals in diversity patterns. Notably, changes in focal scales sometimes reversed a pattern of over-dispersion into clustering. Organismic scale had a stronger effect than spatial and environmental extent. However, we did not find general rules for the direction of change from over-dispersion to clustering with changing scales. Importantly, these scale issues had only a weak influence when focusing on regional diversity patterns that change along abiotic gradients. Main conclusions Our results call for caution when combining phylogenetic data with distributional data to study how and why communities differ from random expectations of phylogenetic relatedness. These analyses seem to be robust when the focus is on relating community diversity patterns to variation in habitat conditions, such as abiotic gradients. However, if the focus is on identifying relevant assembly rules for local communities, the uncertainty arising from a certain scale choice can be immense. In the latter case, it becomes necessary to test whether emerging patterns are robust to alternative scale choices. PMID:24791149