PEOPLE IN PHYSICS: Interview with Peter Higgs

NASA Astrophysics Data System (ADS)

Fancey, Conducted by Norman

1998-01-01

Peter Higgs, FRSE, FRS held until recently a personal chair in theoretical physics at the University of Edinburgh and is now an emeritus professor. Peter is well known for predicting the existence of a new particle, the Higgs boson - as yet unconfirmed. He has been awarded a number of prizes in recognition of his work, most recently the Paul Dirac Medal and Prize for outstanding contributions to theoretical physics from the Institute of Physics and the 1997 High Energy and Particle Physics Prize by the European Physical Society.

Peter Waterman and his scientific legacy

NASA Technical Reports Server (NTRS)

Mishchenko, Michael I.; Kahnert, Michael; Mackowski, Daniel W.; Wriedt, Thomas

2013-01-01

Peter C. Waterman, a giant figure in the theory of electromagnetic, acoustic, and elastic wave scattering, passed away on 3 June, 2012. In view of his fundamental contributions, which to a large degree have guided the progress of these disciplines over the past five decades and affected profoundly the multifaceted research published in the Journal of Quantitative Spectroscopy and Radiative Transfer (JQSRT), we felt that it would be appropriate to solicit papers for a special issue of JQSRT commemorating Peter Waterman's scientific legacy. This initiative was endorsed by the JQSRT management and has resulted in a representative collection of high-quality papers which have undergone the same peer scrutiny as any paper submitted to JQSRT.

Peter N. Ciesielski | NREL

Science.gov Websites

Biomaterials Peter.Ciesielski@nrel.gov | 303-384-7691 Orcid ID http://orcid.org/0000-0003-3360-9210 Research background and training. My research encompasses many aspects of bioenergy and biomaterials science. Biomass research aims to improve ways by which biomass can be used as a sustainable and renewable source of fuels

Peter Pindar (John Wolcot).

ERIC Educational Resources Information Center

Vales, Robert L.

This book is designed as an introduction to John Wolcot's works for the general reader, the college student, and the college teacher. Wolcot, whose pen name was Peter Pindar, wrote topical satire on public personalities of the eighteenth century, and his methods of criticism are the motif which guides each chapter and which unites all the satires…

The Quantum Logical Challenge: Peter Mittelstaedt's Contributions to Logic and Philosophy of Science

NASA Astrophysics Data System (ADS)

Beltrametti, E.; Dalla Chiara, M. L.; Giuntini, R.

2017-12-01

Peter Mittelstaedt's contributions to quantum logic and to the foundational problems of quantum theory have significantly realized the most authentic spirit of the International Quantum Structures Association: an original research about hard technical problems, which are often "entangled" with the emergence of important changes in our general world-conceptions. During a time where both the logical and the physical community often showed a skeptical attitude towards Birkhoff and von Neumann's quantum logic, Mittelstaedt brought into light the deeply innovating features of a quantum logical thinking that allows us to overcome some strong and unrealistic assumptions of classical logical arguments. Later on his intense research on the unsharp approach to quantum theory and to the measurement problem stimulated the increasing interest for unsharp forms of quantum logic, creating a fruitful interaction between the work of quantum logicians and of many-valued logicians. Mittelstaedt's general views about quantum logic and quantum theory seem to be inspired by a conjecture that is today more and more confirmed: there is something universal in the quantum theoretic formalism that goes beyond the limits of microphysics, giving rise to interesting applications to a number of different fields.

R. S. Peters' Normative Conception of Education and Educational Aims

ERIC Educational Resources Information Center

Katz, Michael S.

2009-01-01

This article aims to highlight why R. S. Peters' conceptual analysis of "education" was such an important contribution to the normative field of philosophy of education. In the article, I do the following: 1) explicate Peters' conception of philosophy of education as a field of philosophy and explain his approach to the philosophical analysis of…

Richard Peters and Valuing Authenticity

ERIC Educational Resources Information Center

Degenhardt, M. A. B.

2009-01-01

Richard Peters has been praised for the authenticity of his philosophy, and inquiry into aspects of the development of his philosophy reveals a profound authenticity. Yet authenticity is something he seems not to favour. The apparent paradox is resolved by observing historical changes in the understanding of authenticity as an important value.…

Against the Corporate Culture Ideology: An Interview with Peter Mayo

ERIC Educational Resources Information Center

Suoranta, Juha

2010-01-01

This article presents an interview with Peter Mayo, author and expert in the field of sociology of adult education, on his major influences in this area, his books, and his views on the role of radical adult education and radical scholarship in the future. In the interview, Peter Mayo states that his initial view of adult education was quite a…

Peter & Jane: A Program Showcase

ERIC Educational Resources Information Center

Kalinowski, Michael

2008-01-01

This article features the early childhood programs at Peter & Jane Kindergarten located in Petaling Java, Malaysia. The primary purpose of the programs is to lay a strong foundation for a lifelong love of learning in each child. According to principal Patricia Teh, the activities are funded by parent fees and serve children two to six years of…

Von Hippel-Lindau Disease

MedlinePlus

What is Von Hippel-Lindau disease (VHL)? Von Hippel-Lindau disease (VHL) is a rare disease that causes tumors and cysts to grow in your body. They ... can become cancerous. What causes Von Hippel-Lindau disease (VHL)? Von Hippel-Lindau disease (VHL) is a ...

Peter Waterman and T-Matrix Methods

NASA Technical Reports Server (NTRS)

Mishchenko, M. I.; Martin, P.A.

2013-01-01

This paper summarizes the scientific legacy of Peter C. Waterman (1928-2012) who introduced concepts and theoretical techniques that have had a major impact on the fields of scattering by particles and particle groups, optical particletcharacterization, radiative transfer, and remote sensing. A biographical sketch is also included.

The Future of the Digital Library: An Interview with Tom Peters

ERIC Educational Resources Information Center

Morrison, James L.; Peters, Tom

2005-01-01

This article presents an interview with Tom Peters, an academic librarian and founder of TAP Information Services, a firm that provides consulting services to libraries and other organizations in the information industry. Peters also serves as a consultant to LibraryCity, an ambitious project that seeks to make thousands of e-books in easy-to-use…

Ripples from a Passing Ship: Memories; and a Legacy of Richard Peters

ERIC Educational Resources Information Center

Harris, Kevin

2013-01-01

This paper outlines aspects and dimensions of my "relationship" with Richard Peters from 1966 onward. The underlying suggestion is that, while Peters' contribution to philosophy of education was undeniably of major proportions, both that contribution and his legacy are institutional rather than substantive. (Contains 15 notes.)

Peter V.Hobbs (1936-2005)

NASA Astrophysics Data System (ADS)

Wallace, John M.

Peter Hobbs, a professor in the Department of Atmospheric Sciences at the University of Washington in Seattle, died of pancreatic cancer on 25 July 2005.Born in 1936, Hobbs experienced what he described as “a wild, adventurous youth on the streets of postwar London.” He engaged in competitive swimming and at age 13 held the title of Junior Boxing Champion of the County of Surrey.

Wernher von Braun

NASA Image and Video Library

1959-01-01

This photograph of Dr. von Braun, shown here to the left of General Bruce Medaris, was taken in the fall of 1959, immediately prior to Medaris' retirement from the Army. At the time, von Braun and his associates worked for the Army Ballistics Missile Agency in Huntsville, Alabama. Those in the photograph have been identified as Ernst Stuhlinger, Frederick von Saurma, Fritz Mueller, Hermarn Weidner, E.W. Neubert (partially hidden), W.A. Mrazek, Karl Heimburg, Arthur Rudolph, Otto Hoberg, von Braun, Oswald Lange, Medaris, Helmut Hoelzer, Hans Maus, E.D. Geissler, Hans Heuter, and George Constan.

Wernher von Braun

NASA Image and Video Library

1977-06-16

Dr. Wernher von Braun served as Marshall Space Flight Center's first director from July 1, 1960 until January 27, 1970, when he was appointed NASA Deputy Associate Administrator for Planning. Following World War II, Dr. von Braun and his German colleagues arrived in the United States under Project Paper Clip to continue their rocket development work. In 1950, von Braun and his rocket team were transferred from Ft. Bliss, Texas to Huntsville, Alabama to work for the Army's rocket program at Redstone Arsenal and later, NASA's Marshall Space Flight Center. Under von Braun's leadership, Marshall developed the Saturn V launch vehicle which took Apollo astronauts to the moon. Dr. von Braun died in Alexandria, Va., on June 16, 1977, seven years after his NASA appointment. This photo was taken at the site where he was laid to rest.

Autonomy in R. S. Peters' Educational Theory

ERIC Educational Resources Information Center

Cuypers, Stefaan E.

2009-01-01

Autonomy is, among other things, an actual psychological condition, a capacity that can be developed, and an educational ideal. This paper contextualises, analyses, criticises and extends the theory of Richard S. Peters on these three aspects of autonomy.

Wernher von Braun

NASA Image and Video Library

1960-01-01

Dr. Wernher von Braun served as Marshall Space Flight Center's first director from July 1, 1960 until January 27, 1970, when he was appointed NASA Deputy Associate Administrator for Plarning. Following World War II, Dr. von Braun and his German colleagues arrived in the United States under Project Paperclip to continue their rocket development work. In 1950, von Braun and his rocket team were transferred from Ft. Bliss, Texas to Huntsville, Alabama to work for the Army's rocket program at Redstone Arsenal and later, NASA's Marshall Space Flight Center. Under von Braun's leadership, Marshall developed the Saturn V launch vehicle which took Apollo astronauts to the moon.

Peter Koch: wizard of wood use

Treesearch

M.E. Lora

1978-01-01

Like his pioneer forefathers, Peter Koch sees opportunity where others see obstacles. And his vision is helping to reshape the wood industry. Since 1963 Koch has directed research on processing southern woods for the U.S. Forest Service's Southern Forest Experiment Station in Pineville, Louisiana. In that time, he has invented six revolutionary machines, developed...

Pregnancy and delivery in women with von Willebrand's disease and different von Willebrand factor mutations.

PubMed

Castaman, Giancarlo; Tosetto, Alberto; Rodeghiero, Francesco

2010-06-01

Pregnancy in von Willebrand's disease may carry a significant risk of bleeding. Information on changes in factor VIII and von Willebrand factor and pregnancy outcome in relation to von Willebrand factor gene mutations are very scanty. We examined biological response to desmopressin, changes in factor VIII and von Willebrand factor and pregnancy outcome in a cohort of 23 women with von Willebrand's disease characterized at molecular level and prospectively followed during 2000-2007. Thirty-one pregnancies occurred during the study period. Remarkably, similar changes of factor VIII and von Willebrand factor were observed after desmopressin and during pregnancy in nine women with R854Q, R1374H, V1665E, V1822G and C2362F mutations. Women with von Willebrand's disease and R1205H and C1130F mutations (17 pregnancies in 12 women) had only a slight increase of factor VIII and von Willebrand factor during pregnancy while their response to desmopressin was marked but short-lived. For these women, two to three desmopressin administrations within the first 48 hours were sufficient to successfully manage vaginal delivery. Two women with recessive von Willebrand's disease due to compound heterozygosity for different gene mutations had a spontaneous, major increase in factor VIII while von Willebrand factor remained severely reduced. Desmopressin increased factor VIII and was clinically useful in the first case, while a factor VIII/von Willebrand factor concentrate was required in the second patient not responsive to the compound. Factor VIII/von Willebrand factor concentrate was also required for two women with type 2 A von Willebrand's disease with V1665E mutations who had no von Willebrand factor activity change during pregnancy. In one of them, delayed bleeding occurred 15 days later requiring treatment with Factor VIII/von Willebrand factor concentrate. No miscarriages or stillbirths occurred. Close follow-up and detailed guidelines for the management of parturition have

Wernher von Braun

NASA Image and Video Library

1970-02-24

In 1970 Marshall Space Flight Center (MSFC) Director Dr. Wernher von Braun (right) was reassigned to NASA Headquarters to serve as Deputy Associate Administrator for Plarning. Prior to his transfer, Dr. von Braun was honored for his career in Huntsville, Alabama, with the celebration of "Wernher von Braun Day." Among those participating were Alabama Governor Albert Brewer (left) and Alabama Senator John Sparkman (center). (Courtesy of Huntsville/Madison County Public library)

Ordovician conodonts and stratigraphy of the ST. Peter sandstone and glen wood shale, central United States

USGS Publications Warehouse

Witzke, B.J.; Metzger, R.A.

2005-01-01

The age of the St. Peter Sandstone in the central and northern Midcontinent has long been considered equivocal because of the general absence of biostratigraphically useful fossils. Conodonts recovered from the St. Peter Sandstone in Iowa, Minnesota, Nebraska, and Kansas for this study help place some age constraints on this renowned formation in its northern and western extent. Faunas from the lower St. Peter include Phragmodus flexuosus, Cahabagnathus sp., and Leptochirognathus sp., and a late Whiterockian (Chazyan) correlation is indicated. Juvenile or immature elements of P. flexuosus from these collections show morphologies trending toward P. cognitus and P. inflexus, and paedomorphic derivation of these latter species is proposed. Diverse assemblages of hyaline forms also occur in the St. Peter strata (Erismodus spp., Erraticodon sp., Curtognathus sp., Coleodus sp., Archeognathus sp., Stereoconus sp., others) along with various albid elements (Plectodina sp., Eoplacognathus sp., others). The overlying Glenwood Shale contains abundant conodonts dominated by Phragmodus cognitus, Erismodus sp., and Chirognathus duodactylus, and the fauna is interpreted as an early Mohawkian (Blackriveran) association. Certain thin shale units in the St. Peter-Glenwood succession represent condensed intervals, in part reflected by their exceptionally high conodont abundances. Some organic-rich phosphatic shale units in the lower St. Peter of western Iowa have produced equivalent yields of tens of thousands of conodonts per kilogram, and many Glenwood Shale samples yield thousands of conodonts per kilogram. Previous depositional models have proposed that the St. Peter is primarily a succession of littoral and nearshore facies forming a broadly diachronous transgressive sheet sand. However, broad-scale diachroneity cannot be demonstrated with available biostratigraphic control. The recognition of condensed marine shale units, phosphorites, ironstones, and pyritic hardgrounds in the

Wernher von Braun

NASA Image and Video Library

1954-01-01

Marshall Center Director Dr. Wernher Von Braun is pictured with Walt Disney during a visit to the Marshall Space Flight Center in 1954. In the 1950s, Dr. Von Braun while working in California on the Saturn project, also worked with Disney studios as a technical director in making three films about Space Exploration for television. Disney's tour of Marshall in 1965 was Von Braun's hope for a renewed public interest in the future of the Space Program at NASA.

Peter the Great: Linking Military Strategy to National Objectives in Imperial Russia

DTIC Science & Technology

1999-04-01

provisions) and because its forces could not move fast enough to overcome the Ottoman’s delaying tactics.1 Vasili Golitsyn, Alexei’s representative to...conclusion when, in 1694, he pitted six Streltsy regiments against his two new Guards regiments (Preobrazhenskii and Semenovskii) in mock combat. The...Press, 1971. Gray, Ian. Peter the Great: Emperor of all Russia. New York: J.B.Lippincott, 1960. Klychevsky, Vasili . Peter the Great. Boston: Beacon

Team Leader: Tom Peters--TAP Information Services

ERIC Educational Resources Information Center

Library Journal, 2005

2005-01-01

Tom Peters packs 36 hours of work into the confines of a 24-hour day. Without breaking a sweat, he juggles multiple collaborative projects, which currently include an Illinois academic library shared storage facility; a multistate virtual reference and instruction service for blind and visually impaired individuals (InfoEyes); a virtual meeting…

R. S. Peters: The Reasonableness of Ethics

ERIC Educational Resources Information Center

Haynes, Felicity

2013-01-01

This article will begin by examining the extent to which R. S. Peters merited the charge of analytic philosopher. His background in social psychology allowed him to become more pragmatic and grounded in social conventions and ordinary language than the analytic philosophers associated with empiricism, and his gradual shift from requiring internal…

Dr. Wernher von Braun

NASA Technical Reports Server (NTRS)

2004-01-01

Dr. von Braun is looking out from a 10th floor window of building 4200 at the Marshall Space Flight Center (MSFC). He was the first Center Director and served as the Director from July 1960 through February 1970. Following World War II, Dr. von Braun and his German colleagues arrived in the United States under the Project Paperclip (American acquisition of German rocket experts) to continue their rocket development work. In 1950, von Braun and his German Rocket Team (also called the Peenemuende Team) were transferred from Ft. Bliss, Texas to Huntsville, Alabama to work for the Army's rocket program at Redstone Arsenal and later, NASA's Marshall Space Flight Center (MSFC). Under Dr. von Braun's leadership, MSFC developed the Saturn V launch vehicle, which placed the first men, two American astronauts, on the Moon. Wernher von Braun's life was dedicated to expanding man's knowledge through the exploration of space.

Professor Peter Choyce: an early pioneer of intraocular lenses and corneal/refractive surgery.

PubMed

Pandey, Suresh K; Apple, David J

2005-06-01

Professor Peter Choyce, FRCS, DOMS, MS, was one of the pioneers of intraocular lens implant surgery. He developed an interest in artificial lens implantation following cataract surgery, a procedure that was widely criticized by the ophthalmic establishment in the UK, Europe, North America and other countries. Owing to the opposition to the intraocular lenses, Peter Choyce together with Sir Harold Ridley co-founded the International Intraocular Implant Club in 1966, which was responsible for the gradual acceptance of artificial lens implantation. Peter Choyce developed several models of intraocular lens, but did not patent the majority of them. The Choyce Mark IX, manufactured by Rayner Intraocular Lenses, became the first US Food and Drug Administration-approved intraocular lens in 1981. A review of Peter Choyce's record confirms a significant number of original innovations in the field of anterior segment surgery, including many procedures taken for granted today, but not associated with his name. These include early work on both kerato- and intraocular lens-refractive procedures, keratoprosthesis, pioneering paediatric implant procedures and others. Unfortunately his tenacious adherence to anterior chamber lens technology, while in general clinically sound, caused many to question his influence and hence he remained poorly understood even until after his death. He passed away on 8 August 2001 after a long fight with colon cancer. In this article, we provide evidence and elaborate Peter Choyce's accomplishments, which places him as one of the most innovative ophthalmologist in his surgical field in the twentieth century.

Mutations at the PAX6 locus are found in heterogeneous anterior segment malformations including Peters' anomaly.

PubMed

Hanson, I M; Fletcher, J M; Jordan, T; Brown, A; Taylor, D; Adams, R J; Punnett, H H; van Heyningen, V

1994-02-01

Mutation or deletion of the PAX6 gene underlies many cases of aniridia. Three lines of evidence now converge to implicate PAX6 more widely in anterior segment malformations including Peters' anomaly. First, a child with Peters' anomaly is deleted for one copy of PAX6. Second, affected members of a family with dominantly inherited anterior segment malformations, including Peters' anomaly are heterozygous for an R26G mutation in the PAX6 paired box. Third, a proportion of Sey/+ Smalleye mice, heterozygous for a nonsense mutation in murine Pax-6, have an ocular phenotype resembling Peters' anomaly. We therefore propose that a variety of anterior segment anomalies may be associated with PAX6 mutations.

Reading R. S. Peters on Education Today

ERIC Educational Resources Information Center

Cuypers, Stefaan E.; Martin, Christopher

2009-01-01

This introduction to this special issue offers an overview of R. S. Peters' seminal role in the development of modern philosophy of education, acknowledging the originality and range of his work, and indicating his continuing importance to the field. It explains the structure and organisation of the collection and provides a rationale for this…

The Existential Concern of the Humanities R. S. Peters' Justification of Liberal Education

ERIC Educational Resources Information Center

Cuypers, Stefaan E.

2018-01-01

Richard Stanley Peters was one of the founding fathers of analytic philosophy of education in the twentieth century. After reviewing Peters' disentanglement of the ambiguities of liberal education, I reconstruct his view on the status and the existential foundations of the humanities. What emerges from my reconstruction is an original…

The "Physically Educated" Person: Physical Education in the Philosophy of Reid, Peters and Aristotle

ERIC Educational Resources Information Center

MacAllister, James

2013-01-01

This article will derive a definition and account of the physically educated person, through an examination of the philosophy of Andrew Reid, Richard Peters and Aristotle. Initially, Reid's interpretation of Peters' views about the educational significance of practical knowledge (and physical education) will be considered. While it will…

Wernher von Braun

NASA Image and Video Library

1959-01-01

Five of the seven original astronauts are seen with Dr. von Braun inspecting the Mercury-Redstone hardware in the Fabrication Laboratory of Army Ballistic Missile Agency (ABMA) in 1959. Left to right: Astronauts Walter Schirra, Alan Shepard, John Glenn, Scott Carpenter, Gordon Cooper, and Dr. von Braun.

Peter Jarvis and the Understanding of Adult Learning

ERIC Educational Resources Information Center

Illeris, Knud

2017-01-01

By comparing Peter Jarvis' understanding of learning with two other approaches--which Jarvis himself has referred to as "the most comprehensive": Etienne Wenger's "social theory of learning" and my own psychologically oriented theory of "the three dimensions of learning"--it becomes evident that Jarvis' understanding…

Anterior segment dysgenesis (Peters' anomaly) in two snow leopard (Panthera uncia) cubs.

PubMed

Hamoudi, Hassan; Rudnick, Jens-Christian; Prause, Jan U; Tauscher, Kerstin; Breithaupt, Angele; Teifke, Jens P; Heegaard, Steffen

2013-07-01

Two sibling snow leopards, a male and a female, with bilateral anterior segment dysgenesis (ASD), are reported. Both snow leopards also had colobomas of both upper eyelids. All eyes exhibited a central corneal opacity associated with a defect in posterior corneal stroma, endothelium and Descemet's membrane. Iris strands were present attached to the termination of Descemet's membrane and to the periphery of the posterior corneal defect. The iris was hypoplastic, and cataract was present in all four eyes. The left eye of the female was microphthalmic, with no trabecular meshwork and with persistent remnant of the hyaloid artery. The male had hydrocephalus and thus some of the features of Peters' plus syndrome (Peters' anomaly in addition to systemic malformations). The histological findings in the eyes of these snow leopard siblings are identical with those described in humans with Peters' anomaly. © 2012 American College of Veterinary Ophthalmologists.

Theories of Power, Poverty, and Law: In Commemoration of the Contributions of Peter Bachrach--The Challenge of Peter Bachrach

ERIC Educational Resources Information Center

Lukes, Steven

2010-01-01

Peter Bachrach had a remarkable impact on those who encountered him in person and on generations of readers. Judith Baer vividly captures, among other things, his inspiring, emboldening influence on his students and the sheer fun it was to be with him. My recollections are of exciting, forward moving, intense, and probing arguments, in private and…

The Statue of Liberty Peter Max Style!

ERIC Educational Resources Information Center

Cunningham, Kathy

2012-01-01

The author's school is only 30 minutes from New York City, so every year when second-graders study towns and cities, the students do a project based on New York City landmarks. This year was the Statue of Liberty. The author introduced Peter Max's famous Pop art to her students, and explained that, as the art world kept changing, artists decided…

1. DOWNRIVER VIEW OF BRIDGE, LOOKING SOUTHSOUTHWEST Peter J. Edwards, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. DOWNRIVER VIEW OF BRIDGE, LOOKING SOUTH-SOUTHWEST Peter J. Edwards, photographer, August 1988 - Four Mile Bridge, Copper Creek Road, Spans Table Rock Fork, Mollala River, Molalla, Clackamas County, OR

Titanisierung von Implantatoberflächen

NASA Astrophysics Data System (ADS)

Zimmermann, Hanngörg; Heinlein, Markus; Guldner, Norbert W.

Titan gilt seit Jahrzehnten als einer der wichtigsten Implantatwerkstoffe in der Medizin. Neben den guten mechanischen Eigenschaften (Leichtigkeit, hohe Festigkeit etc.), besitzen Titanimplantate vor allem eine hervorragende Körperverträglichkeit, so dass die Implantate optimal in den humanen Organismus integriert werden [1]. Ist jedoch aufgrund der Anforderungen an das Implantat eine hohe Flexibilität und/ oder Elastizität gefragt, so scheidet der Werkstoff Titan aufgrund seiner spröden und unflexiblen Materialeigenschaften aus. Die Folge ist der Einsatz von Implantatmaterialien, sowohl künstlichen als auch biologischen Ursprungs, welche nicht selten eine unzureichende Biokompatibilität aufweisen und somit zu Fremdköper- und immunologischen Reaktionen und Einkapselung des Implantates führen können. Die Erhöhung der Körperverträglichkeit, eine Adaption an das biologische Umfeld und eine hohe Biokompatibilität sind demzufolge die wichtigsten Eigenschaften bei der bedarfsgerechten Herstellung von Implantaten und Implantatoberflächen. Zur Gestaltung von innovativen, biokompatiblen Oberflächen stehen unterschiedliche technische Lösungsansätze zur Verfügung. Zum einen besteht die Möglichkeit, geeignete Oberflächeneigenschaften aus dem Grundmaterial selbst zu optimieren. Dies geschieht unter anderem durch Modifikation der Werkstoffoberflächen in Form von Texturierungen und Oberflächenrauhigkeiten. Zum anderen können die Oberflächeneigenschaften unabhängig von denen des Trägermaterials gestaltet werden. Durch Funktionalisierung der Oberflächen mit geeigneten Beschichtungen oder der Zugabe von Medikamenten (Drug Eluting) werden die Kunststoffimplantate dahingehend verändert, dass eine Steigerung der Körperakzeptanz erreicht wird. Die Titanbeschichtung von Implantatoberflächen kombiniert die positiven Materialeigenschaften von Titan und Polymer.

Wernher von Braun

NASA Image and Video Library

1968-01-22

Dr. Wernher Von Braun, stands in front of a Saturn IB Launch Vehicle at Kennedy Space Center (KSC). Dr. Von Braun was Marshall's first Center Director (1960-1970). Under his leadership Marshall was responsible for the development of the Saturn rockets, the Skylab project and getting the United States into Space and landing on the moon with the Apollo missions.

Peter Effect in the Preparation of Reading Teachers

ERIC Educational Resources Information Center

Binks-Cantrell, Emily; Washburn, Erin K.; Joshi, R. Malatesha; Hougen, Martha

2012-01-01

The Peter Effect (Applegate & Applegate, 2004) claimed that one cannot be expected to give what one does not possess. We applied this notion to reading teacher preparation and hypothesized that teacher educators who do not possess an understanding of basic language constructs would not prepare teacher candidates with an understanding of these…

A tribute to Peter A. Rona: A Russian Perspective

NASA Astrophysics Data System (ADS)

Sagalevich, Anatoly; Lutz, Richard A.

2015-11-01

In July 1985 Peter Rona led a cruise of the National Oceanic and Atmospheric Administration (NOAA) ship Researcher as part of the NOAA Vents Program and discovered, for the first time, black smokers, massive sulfide deposits and vent biota in the Atlantic Ocean. The site of the venting phenomena was the Trans-Atlantic Geotraverse (TAG) Hydrothermal Field on the east wall of the rift valley of the Mid-Atlantic Ridge at 26°08‧N; 44°50‧W (Rona, 1985; Rona et al., 1986). In 1986, Peter and an international research team carried out multidisciplnary investigations of both active and inactive hydrothermal zones of the TAG field using the R/V Atlantis and DSV Alvin, discovering two new species of shrimp (Rimicaris exoculata and Chorocaris chacei) (Williams and Rona, 1986) and a hexagonal-shaped form (Paleodictyon nodosum) thought to be extinct (Rona et al., 2009). In 1991 a Russian crew aboard the R/V Akademik Mstislav Keldysh, with two deep-diving, human-occupied submersibles (Mir-1 and Mir-2) (Fig. 1), had the honor of having Peter Rona and a Canadian IMAX film crew from the Stephen Low Company on board to visit the TAG hydrothermal vent field. This was the first of many deep-sea interactions between Russian deep-sea scientists and their colleagues from both the U.S. and Canada. This expedition to the TAG site was part of a major Russian undersea program aimed at exploring extreme deep-sea environments; between 1988 and 2005, the Mir submersibles visited hydrothermal vents and cold seep areas in 20 deep-sea regions throughout the world's oceans (Sagalevich, 2002). Images of several of these areas (the TAG, Snake Pit, Lost City and 9°50‧N vent fields) were obtained using an IMAX camera system emplaced for the first time within the spheres of the Mir submersibles and DSV Alvin in conjunction with the filming of science documentaries (e.g., ;Volcanoes of the Deep Sea;) produced by the Stephen Low Company in conjunction with Emory Kristof of National Geographic and

Operational Art in Cyber Defense

DTIC Science & Technology

2013-04-16

a personal curiosity. I used the masculine when referring to the Commander and the adversary throughout this paper for brevity. Alanis 1...issue 63, (4th quarter 2011): 70-73. 13 Carl von Clausewitz, On War, ed. Michael Howard and Peter Paret, trans . Michael Howard and Peter Paret

R. S. Peters' "The Justification of Education" Revisited

ERIC Educational Resources Information Center

Cuypers, Stefaan E.

2012-01-01

In his 1973 paper "The Justification of Education" R. S. Peters aspired to give a non-instrumental justification of education. Ever since, his so-called "transcendental argument" has been under attack and most critics conclude that it does not work. They have, however, thrown the baby away with the bathwater, when they furthermore concluded that…

Portrait Face-Off: Gilbert Stuart vs. Peter Max

ERIC Educational Resources Information Center

Crumpecker, Cheryl

2012-01-01

When art classes are short and infrequent, it is always a challenge to meet required state and national standards. A unit comparing and contrasting Peter Max's Pop art portraits with the realistic style of Gilbert Stuart's presidential portraits provides an opportunity to address a huge number of these requirements. Focus can change with the age…

Wernher von Braun

NASA Image and Video Library

1970-02-24

Dr. von Braun was honored with a series of farewell events and ceremonies prior to his reassignment to NASA Headquarters in Washington, D.C. Alabama Governor Brewer greets Dr. von Braun following his speech at the front of the Madison County Courthouse in Huntsville, Alabama on February 24, 1970. Behind are Madison County Commissioner James Record, Huntsville Mayor Joe Davis, and U.S. Senator Sparkman.

Wernher von Braun

NASA Image and Video Library

1969-07-24

Apollo 11 splashdown celebration in Huntsville, Alabama, on July 24, 1969. Huntsville Alabama is the home of the Marshall Space Flight Center which developed the Saturn vehicles under the direction of Dr. von Braun. The photo shows Dr. von Braun speaking to the crowd at the Madison County Courthouse as Mayor Joe Davis, Madison County Commissioner James Record and City Council President Ken Johnson look on.

Wernher von Braun

NASA Image and Video Library

1969-07-24

Dr. von Braun is carried aloft on the shoulders of Huntsville city officials during the Apollo 11 celebration in Huntsville, Alabama, on July 24, 1969. Huntsville, Alabama is the home of the Marshall Space Flight Center which developed the Saturn vehicles under the direction of Dr. von Braun. The Apollo 11 lifted off in July and made the first marned lunar landing on the Moon.

Diagnosis and management of von Willebrand's syndrome.

PubMed

Rick, M E

1994-05-01

von Willebrand's disease is the most common of the inherited bleeding disorders. It is caused by quantitative and/or qualitative abnormalities of von Willebrand factor, and it usually presents with bleeding from mucosal surfaces. The diagnosis is confirmed by measuring von Willebrand factor activity and antigen levels, factor VIII activity, and performing a multimer analysis of von Willebrand factor. Treatment may require plasma-derived concentrates, but can often be accomplished with DDAVP, a vasopressin analogue that causes transient release of von Willebrand factor from body storage sites.

My Journey with Peter: Moving Ideas that Matter

ERIC Educational Resources Information Center

Blyth, Dale A.

2012-01-01

Youth development lost a pioneer and a champion, Peter Benson, in October. Benson was a pioneer whose ideas mattered and a champion of approaches to research and its use in the community that has made a difference around the world. Benson's work, life, and spirit have helped transform people's understanding of young people, what it takes to…

Otto Peters on Distance Education: The Industrialization of Teaching and Learning. Routledge Studies in Distance Education.

ERIC Educational Resources Information Center

Keegan, Desmond, Ed.

This book contains new and previously published translations of 11 essays and articles about the industrialization of teaching and learning in distance education that were originally published in German by Otto Peters between 1965 and 1993. A "Preface" (Desmond Keegan) and an introduction placing Peters' writings in their historical…

Peter Drucker, Knowledge Work, and the Structure of Schools.

ERIC Educational Resources Information Center

Tucker, Marc S.

1988-01-01

Discusses Peter Drucker's recommendations in "The Age of Discontinuity" (1969) concerning the decline of manual work, the ascendancy of knowledge work, and the relationship between economic stability and an educated, productive work force. Applies Drucker's principles to the movement to restructure schools, which aims to make line…

Reflections on Peters' View of the Nature and Purpose of Work in Philosophy of Education

ERIC Educational Resources Information Center

Aspin, D. N.

2013-01-01

In this article I describe the analytic approach adopted by Peters, his colleagues and followers of the "London line" in the 1960s and 1970s and argue that, even in those times, other approaches to philosophy of education were being valued and practised. I show that Peters and his colleagues later became aware of the need for philosophy of…

K istorii goroskopa Petra Velikogo %t On the history of horoscope of Peter the Great

NASA Astrophysics Data System (ADS)

Bronshtehn, V. A.

In the first part of the paper the question is discussed if Simeon Polotsky (1629-1680), poet and teacher of children of the Russian tsar Alexei Mikhailovich, was also the author of the horoscope of his son, in the future - Russian emperor Peter the Great, born in 1672. The poems by Simeon Polotsky with astrological contents are analyzed. The conclusion is supported that he could be the author of Peter the Great horoscope. In the second part a recently found text of the horoscope of Peter the Great reconstructed in 1775 by Russian astronomer Andrei Lexell of the request of historian G. F. Miller is published and discussed. It is also compared with texts previously published (in 1842) by Russian historians Pogodin and Polevoi.

Marginal Experiments: Peter Brook and Stepping out Theatre Company

ERIC Educational Resources Information Center

Harpin, Anna

2010-01-01

This article juxtaposes the recent work of Peter Brook with a Bristol-based mental health service-user collective--Stepping Out Theatre Company. Informed by field-work with the company, this chapter explores the aesthetic and political relationship between professional, experimental theatre work and community-based performance practice. Drawing…

R. S. Peters and the Concept of Education

ERIC Educational Resources Information Center

Beckett, Kelvin Stewart

2011-01-01

In this essay Kelvin Beckett argues that Richard Peters's major work on education, "Ethics and Education," belongs on a short list of important texts we can all share. He argues this not because of the place it has in the history of philosophy of education, as important as that is, but because of the contribution it can still make to the future of…

A double commutant theorem for Murray–von Neumann algebras

PubMed Central

Liu, Zhe

2012-01-01

Murray–von Neumann algebras are algebras of operators affiliated with finite von Neumann algebras. In this article, we study commutativity and affiliation of self-adjoint operators (possibly unbounded). We show that a maximal abelian self-adjoint subalgebra of the Murray–von Neumann algebra associated with a finite von Neumann algebra is the Murray–von Neumann algebra , where is a maximal abelian self-adjoint subalgebra of and, in addition, is . We also prove that the Murray–von Neumann algebra with the center of is the center of the Murray–von Neumann algebra . Von Neumann’s celebrated double commutant theorem characterizes von Neumann algebras as those for which , where , the commutant of , is the set of bounded operators on the Hilbert space that commute with all operators in . At the end of this article, we present a double commutant theorem for Murray–von Neumann algebras. PMID:22543165

Peters' Concept of "Education as Initiation": Communitarian or Individualist?

ERIC Educational Resources Information Center

Cotter, Richard

2013-01-01

A central element of Richard Peters' philosophy of education has been his analysis of "education as initiation". Understanding initiation is internally related to concepts of community and what it may mean to be a member. The concept of initiation assumes a mutually interdependent, dynamic relationship between the individual and community that…

University of Florida potato variety trials spotlight: 'Peter Wilcox'

USDA-ARS?s Scientific Manuscript database

'Peter Wilcox’ is a fresh market potato variety selected from progeny of a cross between B0810-1 and B0918-5, and tested under the pedigree B1816-5 by K.G. Haynes. It was jointly released by United States Department of Agriculture, North Carolina Agricultural Research Service, Agricultural Experimen...

Wernher von Braun

NASA Image and Video Library

1964-03-24

Marshall Space Flight Center Director Dr. Wernher von Braun presents Lady Bird Johnson with an inscribed hard hat during the First Lady's March 24, 1964 visit. While at the Marshall Center, Mrs. Johnson addressed Center employees, toured facilities and witnessed test firings of a Saturn I first stage and an F-1 engine. Dr. von Braun is wearing a Texas hat presented to him months earlier by Lyndon Johnson during a visit to the Johnson ranch in Texas.

Abnormal centromere-chromatid apposition (ACCA) and Peters' anomaly.

PubMed

Wertelecki, W; Dev, V G; Superneau, D W

1985-08-01

Abnormal centromere-chromatid apposition (ACCA) was noted in a patient with Peters' anomaly. Previous reports of ACCA emphasized its association with tetraphocomelia and other congenital malformations (Roberts, SC Phocomelia, Pseudothalidomide Syndromes). This report expands the array of congenital malformations associated with ACCA and emphasizes the diagnostic importance of ocular defects for the ascertainment of additional cases of ACCA and its possible relationship with abnormal cell division.

Operational art in the Defense: The German Abwehrschlachten in 1918

DTIC Science & Technology

2012-05-17

2 Carl von Clausewitz, On War, Michael Howard und Peter Paret ed. and trans. (New Jersey: Princeton University Press, 1989...Siegismund, 1937), 74. 21 Jacob Jung , Max von Gallwitz (1852-1937) (Osnabrück: Biblio-Verlag, 1995), 93 & 97. 22 Erich Ludendorff, Meine...23 Jung , Max von Gallwitz (1852-1937), 5-7. 24 Ibid., 8-16. 25 Ibid.,17-23. 13 At the outbreak of the war, Gallwitz received command

Comparing Theory and Practice: An Application of Complexity Theory to General Ridgway’s Success in Korea

DTIC Science & Technology

2010-12-02

Theory Defined 48 Doctrine 48 Interwar Doctrine a Historical Perspective 52 Adaptive Campaigning 53 Carl von Clausewitz 53 Comparative Analysis of...order effects that may be traced through an understanding of the environment. Carl von Clausewitz suggested using history as a tool, to provide a lens...Cworks/Works.htm (accessed 10/2, 2010). 6 Carl von Clausewitz, On War, trans. Ed. Michael Howard and Peter Paret (Princeton: Princeton University

Science Matters Podcast: Questions and Answers with EPA's Dr. Peter Grevatt

EPA Pesticide Factsheets

Listen to a podcast with Dr. Peter Grevatt, the director of EPA's Office of Children's Health Protection, as he answers questions about children's health, or read some of the highlights from the conversation here.

Weighing the Evidence in Peters' Rule: Does Neuronal Morphology Predict Connectivity?

PubMed

Rees, Christopher L; Moradi, Keivan; Ascoli, Giorgio A

2017-02-01

Although the importance of network connectivity is increasingly recognized, identifying synapses remains challenging relative to the routine characterization of neuronal morphology. Thus, researchers frequently employ axon-dendrite colocations as proxies of potential connections. This putative equivalence, commonly referred to as Peters' rule, has been recently studied at multiple levels and scales, fueling passionate debates regarding its validity. Our critical literature review identifies three conceptually distinct but often confused applications: inferring neuron type circuitry, predicting synaptic contacts among individual cells, and estimating synapse numbers within neuron pairs. Paradoxically, at the originally proposed cell-type level, Peters' rule remains largely untested. Leveraging Hippocampome.org, we validate and refine the relationship between axonal-dendritic colocations and synaptic circuits, clarifying the interpretation of existing and forthcoming data. Copyright © 2016 Elsevier Ltd. All rights reserved.

Wernher von Braun

NASA Image and Video Library

1958-01-31

Jet Propulsion Laboratory Director Dr. James Pickering, Dr. James van Allen of the State University of Iowa, and Army Ballistic missionile Agency Technical Director Dr. Wernher von Braun triumphantly display a model of the Explorer I, America's first satellite, shortly after the satellite's launch on January 31, 1958. The Jet Propulsion Laboratory packed and tested the payload, a radiation detection experiment designed by Dr. van Allen. Dr. von Braun's rocket team at Redstone Arsenal in Huntsville, Alabama, developed the Juno I launch vehicle, a modified Jupiter-C.

Liquid Biopsy zur Überwachung von Melanompatienten.

PubMed

Gaiser, Maria Rita; von Bubnoff, Nikolas; Gebhardt, Christoffer; Utikal, Jochen Sven

2018-04-01

In den letzten sechs Jahren wurden verschiedene innovative systemische Therapien zur Behandlung des metastasierten malignen Melanoms (MM) entwickelt. Die konventionelle Chemotherapie wurde durch neuartige Primärtherapien abgelöst, darunter systemische Immuntherapien (Anti-CTLA4- und Anti-PD1-Antikörper; Zulassung von Anti-PDL1-Antikörpern erwartet) und Therapien, die gegen bestimmte Mutationen gerichtet sind (BRAF, NRAS und c-KIT). Daher stehen die behandelnden Ärzte neuen Herausforderungen gegenüber, beispielsweise der Stratifizierung von Patienten für geeignete Behandlungen und der Überwachung von Langzeit-Respondern auf Progression. Folglich werden zuverlässige Methoden zur Überwachung von Krankheitsprogression oder Behandlungsresistenz benötigt. Lokalisierte und fortgeschrittene Krebserkrankungen können zur Bildung zirkulierender Tumorzellen und Tumor-DNA (ctDNA) führen, die sich in Proben von peripherem Blut nachweisen und quantifizieren lassen (Liquid Biopsy). Im Fall von Melanompatienten können die Ergebnisse von Liquid Biopsy als neuartige prädiktive Biomarker bei therapeutischen Entscheidungen hilfreich sein, insbesondere im Zusammenhang mit mutationsbasierten zielgerichteten Therapien. Die Herausforderungen bei der Anwendung der Liquid Biopsy beinhalten strikte Kriterien für den Phänotyp der zirkulierenden MM-Zellen oder ihrer Fragmente und die Instabilität von ctDNA im Blut. In diesem Übersichtsartikel diskutieren wir die Beschränkungen der Liquid Biopsy hinsichtlich ihrer Anwendung in der Routinediagnostik. © 2018 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.

Dr. von Braun Briefing Walt Disney

NASA Technical Reports Server (NTRS)

1965-01-01

Dr. von Braun began his association with Walt Disney in the 1950s when the rocket scientist appeared in three Disney television productions related to the exploration of space. Years later, Dr. von Braun invited Disney and his associates to tour the Marshall Space Flight Center (MSFC) in Huntsville, Alabama. This photograph is dated April 13, 1965. From left are R.J. Schwinghamer from the MSFC, Disney, B.J. Bernight, and Dr. von Braun.

75 FR 63533 - Gulf & Ohio Railways Holding Co., Inc., H. Peter Claussen and Linda C. Claussen-Continuance in...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-15

... DEPARTMENT OF TRANSPORTATION Surface Transportation Board [Docket No. FD 35414] Gulf & Ohio Railways Holding Co., Inc., H. Peter Claussen and Linda C. Claussen--Continuance in Control Exemption--Lancaster & Chester Railroad, LLC Gulf & Ohio Railways Holding Co., Inc. (G&O), H. Peter Claussen and Linda...

PEOPLE IN PHYSICS: Interview with Peter Barham

NASA Astrophysics Data System (ADS)

Membrey, Conducted by Jill

2000-03-01

Dr Peter Barham, Reader in Physics at the University of Bristol, is one of the first winners of an Institute of Physics Public Awareness of Physics award. These are intended for individuals or groups who have demonstrated excellence, inspiration and innovation in bringing physics to the public. In Dr Barham's case, he has been recognized for his very successful lecture demonstrations on the physics of food for a range of audiences, as well as for supporting and encouraging others to promote physics to the general public.

Wernher von Braun

NASA Image and Video Library

1970-06-27

This photograph was taken after Dr. von Braun moved from his post as Director of the Marshall Space Flight Center (MSFC) to Deputy Associate Administrator for Planning at NASA Headquarters. On June 27, 1970, he visited the MSFC again during the center’s 10th anniversary to look at a mockup of the spacecraft that would later be known as Skylab. With von Braun are (left to right): Herman K. Weidner, director of Science and Engineering at MSFC, and James R. Thompson of the center’s Astrionics Laboratory.

Romantic Resonances in the Rhetoric of Peter Elbow's "Writing Without Teachers."

ERIC Educational Resources Information Center

Yager, Kristi

1996-01-01

Seeks to uncover the historical roots within English Romanticism of Peter Elbow's thinking in order to show the depth and complexity of his assumptions about writing. Implicitly refutes charges questioning the intellectual credibility of Elbow's work. (TB)

Verbesserung der Symmetrie von Hirnaufnahmen entlang der Sagittalebene

NASA Astrophysics Data System (ADS)

Ens, Konstantin; Wenzel, Fabian; Fischer, Bernd

Die lokale Symmetrie von Hirnscans entlang der Sagittalebene zu ermitteln und zu modizifieren, ist für eine Reihe neurologischer Anwendungen interessant. Beispielsweise kann der voxelweise Vergleich von rechter und linker Hirnhälfte nur dann Aufschluss über die Lokalisierung von Läsionen geben, wenn durch Transformation ein Hirnscan eine möglichst hohe Symmetrie aufweist. Ein weiteres Anwendungsgebiet ist die Visualisierung von medialen Hirnschnitten, für die die Trennfläche beider Hirnhälfte möglichst eben sein sollte. Diese Arbeit stellt die Entwicklung eines Verfahrens vor, mit dessen Hilfe die Symmetrie von Hirnaufnahmen entlang der Sagittalebene verbessert werden kann. Dies geschieht unter Verwendung von aktiven Konturen, die mit Hilfe einer neuartigen Kostenfunktion gesteuert werden. Experimente am Ende der Arbeit mit strukturellen Kernspinaufnahmen demonstrieren die Leistungsfähigkeit des Verfahrens.

The Possibilities of Transformation: Critical Research and Peter McLaren

ERIC Educational Resources Information Center

Porfilio, Brad J.

2006-01-01

The purpose of this paper is to unveil how Peter McLaren's revolutionary brand of pedagogy, multiculturalism, and research colored my two-year qualitative research study, which unearthed twenty White female future teachers' experiences and perceptions in relationship to computing technology and male-centered computing culture. His ideas positioned…

50 years of comparative biochemistry: The legacy of Peter Hochachka.

PubMed

Buck, L T; Burness, G; Campbell, K L; Darveau, C-A; Driedzic, W; Guderley, H; McClelland, G B; Moon, T W; Moyes, C D; Schulte, P M

2018-02-28

Peter Hochachka was an early pioneer in the field of comparative biochemistry. He passed away in 2002 after 4 decades of research in the discipline. To celebrate his contributions and to coincide with what would have been his 80th birthday, a group of his former students organized a symposium that ran as a satellite to the 2017 Canadian Society of Zoologists annual meeting in Winnipeg, Manitoba (Canada). This Special Issue of CBP brings together manuscripts from symposium attendees and other authors who recognize the role Peter played in the evolution of the discipline. In this article, the symposium organizers and guest editors look back on his career, celebrating his many contributions to research, acknowledging his role in training of generations of graduate students and post-doctoral fellows in comparative biochemistry and physiology. Copyright © 2018. Published by Elsevier Inc.

Peter Bergmann:The Education of a Physicist

NASA Astrophysics Data System (ADS)

Halpern, Paul

2005-12-01

I explore the early life and contributions of Peter Bergmann (1915 2002), focusing on his family background, education, and ideas. I examine how Bergmann’s formative years were shaped by the outspoken influence of his mother, a leading educational reformer; the distinguished reputation of his father, a renowned materials chemist; and his cherished hope of working with Albert Einstein (1879 1955), to whom he eventually became an assistant. Inspired by these and other notable thinkers, Bergmann became an exemplary organizer, educator, and mentor in the fields of general relativity and quantum gravity.

Interview with Peter McLaren, on His Work, on His Visit to Turkey and on Ongoing Popular Struggles

ERIC Educational Resources Information Center

Fassbinder, Samuel Day

2013-01-01

Peter McLaren is, as the back cover of his (2005) Capitalists & Conquerors: a critical pedagogy against empire says, "professor of urban education at the Graduate School of Education and Information Studies at the University of California, Los Angeles". Peter is also now a Distinguished Fellow in Critical Studies at Chapman…

Advocating Science for All: An Interview with Peter J. Fensham

ERIC Educational Resources Information Center

Cardellini, Liberato

2013-01-01

After providing some glimpses of his private life, Peter Fensham, a leading figure of the prestigious Faculty of Education, Monash University (and now emeritus professor at Queensland University, Brisbane, Australia), gives some suggestions about the conditions that help students to learn meaningfully. He began his career in the field of physical…

Perspective on Open-Access Publishing: An Interview with Peter Suber

ERIC Educational Resources Information Center

Cornwell, Reid; Suber, Peter

2008-01-01

In this edition of Perspectives, Reid Cornwell discusses open-access publishing with Peter Suber, senior researcher at the Scholarly Publishing and Academic Resources Coalition, senior research professor of philosophy at Earlham College, and currently visiting fellow at Yale Law School. Open access means that scholarly work is freely and openly…

Theories of Power, Poverty, and Law: In Commemoration of the Contributions of Peter Bachrach--Empowerment and Poverty

ERIC Educational Resources Information Center

Levi, Margaret

2010-01-01

My subject is the way Peter Bachrach addressed the question of poverty. But given that I was his student and research assistant and that I am a political scientist largely because of him, it is impossible to resist a few words about the experience of being in his classrooms. Peter was an inspiring teacher of politics. The substantive content of…

A note on derivations of Murray–von Neumann algebras

PubMed Central

Kadison, Richard V.; Liu, Zhe

2014-01-01

A Murray–von Neumann algebra is the algebra of operators affiliated with a finite von Neumann algebra. In this article, we first present a brief introduction to the theory of derivations of operator algebras from both the physical and mathematical points of view. We then describe our recent work on derivations of Murray–von Neumann algebras. We show that the “extended derivations” of a Murray–von Neumann algebra, those that map the associated finite von Neumann algebra into itself, are inner. In particular, we prove that the only derivation that maps a Murray–von Neumann algebra associated with a factor of type II1 into that factor is 0. Those results are extensions of Singer’s seminal result answering a question of Kaplansky, as applied to von Neumann algebras: The algebra may be noncommutative and may even contain unbounded elements. PMID:24469831

A note on derivations of Murray-von Neumann algebras.

PubMed

Kadison, Richard V; Liu, Zhe

2014-02-11

A Murray-von Neumann algebra is the algebra of operators affiliated with a finite von Neumann algebra. In this article, we first present a brief introduction to the theory of derivations of operator algebras from both the physical and mathematical points of view. We then describe our recent work on derivations of Murray-von Neumann algebras. We show that the "extended derivations" of a Murray-von Neumann algebra, those that map the associated finite von Neumann algebra into itself, are inner. In particular, we prove that the only derivation that maps a Murray-von Neumann algebra associated with a factor of type II1 into that factor is 0. Those results are extensions of Singer's seminal result answering a question of Kaplansky, as applied to von Neumann algebras: The algebra may be noncommutative and may even contain unbounded elements.

Influence of depositional environment on diagenesis in St. Peter sandstone, Michigan basin

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lundgren, C.E. Jr.; Barnes, D.A.

1989-03-01

The Middle Ordovician St. Peter Sandstone in the Michigan basin was deposited in marine peritidal to storm-dominated, outer shelf depositional environments that evolved in a regionally significant transgressive pattern. The formation is bounded by carbonate and shaly clastic strata of the Prairie du Chien Group below and is transitional to condensed sequence clastics and carbonates of the Glenwood Formation above. Sedimentologic and petrographic analysis of conventional core from 25 wells suggests that reservoir quality in the formation is strongly dependent on a complex diagenetic history, especially the nature and subsequent dissolution of intergranular carbonate in the sandstone. Petrographic evidence indicatesmore » that porosity in the formation formed by dissolution of precursor dolomite of various origins and, locally, the formation of pore-filling authigenic clay (chlorite-illite). Authigenic clay is the incongruent dissolution product of dolomite, detrital K-feldspar, and, possibly, muscovite and results in diminished reservoir quality where abundant in the St. Peter Sandstone. Authigenic clay is volumetrically more significant in the upper portions of the formation and is associated with higher concentrations of detrital K-feldspar. Depositional facies controlled the distribution and types of intergranular carbonate (now dolomite) and detrital K-feldspar in the St. Peter Sandstone and hence reservoir quality; both components were more significant in storm-shelf sandstone facies.« less

Analyse der pharmazeutischen Versorgungssituation von Patienten mit Psoriasis-Arthritis auf Basis von Routinedaten der Gesetzlichen Krankenversicherung.

PubMed

Sondermann, Wiebke; Ventzke, Julia; Matusiewicz, David; Körber, Andreas

2018-03-01

Die Psoriasis-Arthritis (PsA) gehört zu den chronisch entzündlichen Gelenkerkrankungen. Trotz zahlreicher versorgungswissenschaftlicher Studien in Deutschland liegen zur pharmazeutischen Versorgungssituation von PsA-Patienten bisher kaum aktuelle Ergebnisse vor. Mit Hilfe einer systematischen Literaturrecherche sowie anhand von Routinedaten der Allgemeinen Ortskrankenkasse (AOK) Rheinland/Hamburg wird ein aktueller Überblick über die pharmazeutische Versorgung von PsA-Patienten in Deutschland gegeben. Selektiert wurden Versicherte aus dem ambulanten und stationären Bereich, die im 1. und 2. Quartal des Jahres 2014 die gesicherte Abrechnungsdiagnose Psoriasis-Arthritis L40.5+ aufwiesen. Anschließend wurden auf Basis dieser "vorab definierten" Kohorte die Arzneimitteldaten für 5 Jahre (01.01.2010-31.12.2014) abgerufen. Es konnten insgesamt n  =  3205 Versicherte (45 % männlich, 55 % weiblich) der AOK Rheinland/Hamburg mit einer gesicherten PsA-Diagnose selektiert werden. Das Durchschnittsalter betrug 58,9 Jahre. 53,7 % der PsA-Patienten wurden mit systemischen PsA-relevanten Arzneimitteln versorgt. Nichtsteroidale Antirheumatika (NSAR) wurden am häufigsten verordnet, gefolgt von systemischen Glucocorticoiden. Von den selektierten PsA-Patienten, die eine Systemtherapie erhielten, wurden 72,1 % mittels einer Disease-modifying-antirheumatic-Drug (DMARD)-Monotherapie behandelt, gefolgt von der Kombinationstherapie aus DMARDs und Biologika (20,9 %). Die pharmakologische Therapie der PsA muss eine Gewährleistung zwischen adäquater Versorgung der PsA mit Verhinderung der Krankheitsprogression und ökonomischer Verantwortung darstellen. © 2018 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.

An interview with Peter H. Buschang.

PubMed

Buschang, Peter H; dos Santos-Pinto, Ary; Araújo, Eustáquio; Ribeiro, Gerson Luiz Ulema; Jacob, Helder Baldi; Gandini Júnior, Luiz Gonzaga

2014-01-01

Dr. Peter Buschang is regent professor and director of orthodontic research. He has been at Texas A&M University Baylor College of Dentistry since 1988. Dr. Buschang received his PhD in 1980 from the University of Texas at Austin; he spent 3 years as a NIDR postdoctoral fellow at the University of Connecticut, and five years as a FRSQ scholar at the University of Montreal. Every year, Dr. Buschang teaches in 16 different courses, 7 of which he directs. In addition to more than 100 lecture hours per year, he spends hundreds of hours mentoring students. For his teaching efforts, Dr. Buschang was awarded the Robert E. Gaylord Award of Excellence in Orthodontic education in 1992, 1998, 2004, and 2010. He also gives 1-2 day evidence-based CE courses throughout the world. The residents he has taught recently honored him by pledging to fund the Peter H. Buschang Endowed Professorship of Orthodontics. His research interests pertain to craniofacial growth and assessment of treatment effects. Dr. Buschang has been funded regularly over the years by the Medical Research Council of Canada, Fonds de le Recherche en Santé du Québec, the NIH, and the American Association of Orthodontics Foundation. He has mentored over 140 Master's and PhD students, and 49 dental students. Dr. Buschang has published over 250 peer-reviewed articles, 15 book chapters and 198 abstracts. He has given over 150 invited talks and lectures in 14 different countries. For his work with the American Board of Orthodontics, Dr. Buschang was awarded the Earl E. and Wilma S. Shepard Award. Dr. Buschang is the only non-orthodontist ever to have been made an honorary member of both the American Association of Orthodontics (2005) and the Edward H. Angle Society of Orthodontics (2009), the two most prestigious orthodontic groups.

New Myositis Classification Criteria-What We Have Learned Since Bohan and Peter.

PubMed

Leclair, Valérie; Lundberg, Ingrid E

2018-03-17

Idiopathic inflammatory myopathy (IIM) classification criteria have been a subject of debate for many decades. Despite several limitations, the Bohan and Peter criteria are still widely used. The aim of this review is to discuss the evolution of IIM classification criteria. New IIM classification criteria are periodically proposed. The discovery of myositis-specific and myositis-associated autoantibodies led to the development of clinico-serological criteria, while in-depth description of IIM morphological features improved histopathology-based criteria. The long-awaited European League Against Rheumatism and American College of Rheumatology (EULAR/ACR) IIM classification criteria were recently published. The Bohan and Peter criteria are outdated and validated classification criteria are necessary to improve research in IIM. The new EULAR/ACR IIM classification criteria are thus a definite improvement and an important step forward in the field.

The Contribution of Iona and Peter Opie to Children's Literature.

ERIC Educational Resources Information Center

McKinney, Barbara J.

Iona and Peter Opie's contribution to children's literature began with a volume on the origins of nursery rhymes. A nursery rhyme tells a brief and memorable surrealist story about people, animals, or familiar activities. Most nursery rhymes were not originally composed for children but were fragments of ballads or folk songs, remnants of ancient…

An Intimate Portrait of Evaluation Mentorship under Peter H. Rossi

ERIC Educational Resources Information Center

Chen, Huey T.

2007-01-01

The author grew up in Taiwan and in 1995 enrolled in Kent State University's PhD program in sociology. Early in his doctoral career at Kent State, he took a program evaluation course offered by Irwin Deutscher. The textbook he used in the class was Peter Rossi and Walter Williams's 1972 book, "Evaluating Social Programs: Theory, Practice, and…

Shaping the Global Civil Society: An Interview with Michael Peters

ERIC Educational Resources Information Center

Heraud, Richard; Tesar, Marek

2017-01-01

Professor Michael A. Peters has worked in an era of transformation that has taken him from a labour-intensive paper-based form of production to the computerised reproduction of thought, and the current shift in the publishing landscape from a reader-subscription to an author-pays model. Most of what he has learned in publishing and editing he has…

Performance Evaluation Tests for Environmental Research (PETER): evaluation of 114 measures

NASA Technical Reports Server (NTRS)

Bittner, A. C. Jr; Carter, R. C.; Kennedy, R. S.; Harbeson, M. M.; Krause, M.

1986-01-01

The goal of the Performance Evaluation Tests for Environmental Research (PETER) Program was to identify a set of measures of human capabilities for use in the study of environmental and other time-course effects. 114 measures studied in the PETER Program were evaluated and categorized into four groups based upon task stability and task definition. The Recommended category contained 30 measures that clearly obtained total stabilization and had an acceptable level of reliability efficiency. The Acceptable-But-Redundant category contained 15 measures. The 37 measures in the Marginal category, which included an inordinate number of slope and other derived measures, usually had desirable features which were outweighed by faults. The 32 measures in the Unacceptable category had either differential instability or weak reliability efficiency. It is our opinion that the 30 measures in the Recommended category should be given first consideration for environmental research applications. Further, it is recommended that information pertaining to preexperimental practice requirements and stabilized reliabilities should be utilized in repeated-measures environmental studies.

Diagenetic controls on reservoir heterogeneity in St. Peter Sandstone, deep Michigan basin

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barnes, D.A.; Turmelle, T.M.; Adam, R.

1989-03-01

The St. Peter Sandstone is a highly productive gas and condensate reservoir throughout the central part of the Michigan basin. Production occurs in several intervals: a laterally continuous zone at the top of the formation typified in the Woodville, Falmouth, and Rose City fields and less continuous intervals lower in the formation typified in the Ruwe Gulf zone of the Reed City field. Porosity is not limited to hydrocarbon productive zones, however. Diagenesis has dramatically modified primary mineralogy and textures in the formation. Dominant diagenetic components are quartz, dolomite, and clay authigenic cements, extensive chemical compaction, and pervasive mineral leaching.more » Their model for sandstone diagenesis is consistent throughout the basin. Variation in the significance of these diagenetic components is strongly templated by stratigraphically predictable facies variations within the St. Peter Sandstone.« less

Clarifying the link between von Neumann and thermodynamic entropies

NASA Astrophysics Data System (ADS)

Deville, Alain; Deville, Yannick

2013-01-01

The state of a quantum system being described by a density operator ρ, quantum statistical mechanics calls the quantity - kTr( ρln ρ), introduced by von Neumann, its von Neumann or statistical entropy. A 1999 Shenker's paper initiated a debate about its link with the entropy of phenomenological thermodynamics. Referring to Gibbs's and von Neumann's founding texts, we replace von Neumann's 1932 contribution in its historical context, after Gibbs's 1902 treatise and before the creation of the information entropy concept, which places boundaries into the debate. Reexamining von Neumann's reasoning, we stress that the part of his reasoning implied in the debate mainly uses thermodynamics, not quantum mechanics, and identify two implicit postulates. We thoroughly examine Shenker's and ensuing papers, insisting upon the presence of open thermodynamical subsystems, imposing us the use of the chemical potential concept. We briefly mention Landau's approach to the quantum entropy. On the whole, it is shown that von Neumann's viewpoint is right, and why Shenker's claim that von Neumann entropy "is not the quantum-mechanical correlate of thermodynamic entropy" can't be retained.

Globalisation in Africa: Reflecting on Peter Jarvis's Superstructure and Substructure Model

ERIC Educational Resources Information Center

Preece, Julia

2017-01-01

This paper reflects on Peter Jarvis' book "Globalisation, lifelong learning and the learning society," volume 2--in which he describes human learning within a global context and factors contributing to globalisation. He describes the relationship of power between countries manifested as the superstructure and sub structure. The paper…

Idiopathic inflammatory myopathies in adults: A comparative study of Bohan and Peter and European Neuromuscular Center 2004 criteria.

PubMed

Challa, Sundaram; Jakati, Saumya; Uppin, Megha S; Kannan, Meena A; Liza, Rajasekhar; Murthy Jagarlapudi, M K

2018-01-01

Bohan and Peter criteria are widely used for the diagnosis of idiopathic inflammatory myopathies (IIMs). Recently, European Neuromuscular Center (ENMC) formulated criteria to identify subgroups of IIMs. To compare the two diagnostic criteria in adult IIMs. This was a retrospective review of case records of histologically confirmed IIMs in adults between January 2014 and May 2015. Both the Bohan and Peter, and ENMC 2004 criteria were applied in the same group of patients to subgroup the IIMs. Muscle biopsy was evaluated in all the four domains: muscle fiber, inflammatory, connective tissue, and vascular, with the basic panel of histological stains. Sporadic inclusion body myositis (s-IBM) was diagnosed using ENMC IBM diagnostic research criteria 2011. During the study period, 69 patients fulfilled the ENMC criteria for IIMs including 16 patients with s-IBM. The subgrouping as per the ENMC criteria (53) was: dermatomyositis (DM) in 30; polymyositis (PM) in 2; immune-mediated necrotizing myopathy (IMNM) in 9; and nonspecific myositis (NM) in 12 patients, whereas subgrouping by the Bohan and Peter criteria was DM in 9 and PM with and without connective tissue disease (CTD) in 26 patients only. There was underdiagnosis of DM, as perifascicular atrophy is not recognized as a diagnostic histological feature, and overdiagnosis of PM with and without CTD due to poor characterization of histological features in PM by the Bohan and Peter criteria. Systematic evaluation of muscle biopsy according to the ENMC criteria with basic panel of histochemical stains improved the diagnostic yield of IIM significantly when compared to the Bohan and Peter criteria.

Behavioral Determinants of Drug Action: The Contributions of Peter B. Dews

ERIC Educational Resources Information Center

Barrett, James E.

2006-01-01

Peter B. Dews played a significant role in shaping the distinctive characteristics and defining the underlying principles of the discipline of behavioral pharmacology. His early and sophisticated use of schedules of reinforcement in the 1950s, incorporated from research in the experimental analysis of behavior and integrated into the discipline of…

The Peter Effect Revisited: Reading Habits and Attitudes of College Students

ERIC Educational Resources Information Center

Applegate, Anthony J.; Applegate, Mary DeKonty; Mercantini, Martha A.; McGeehan, Catherine M.; Cobb, Jeanne B.; DeBoy, Joanne R.; Modla, Virginia B.; Lewinski, Kimberly E.

2014-01-01

Certainly a primary goal of literacy education is the creation of avid, enthusiastic, and highly motivated readers. However, in this article revisiting the Peter Effect (Applegate & Applegate, 2004), researchers surveyed more than 1,000 college sophomores and found strikingly low levels of enthusiasm for reading. Only 46.6% of surveyed…

An MRI Von Economo - Koskinas atlas.

PubMed

Scholtens, Lianne H; de Reus, Marcel A; de Lange, Siemon C; Schmidt, Ruben; van den Heuvel, Martijn P

2018-04-15

The cerebral cortex displays substantial variation in cellular architecture, a regional patterning that has been of great interest to anatomists for centuries. In 1925, Constantin von Economo and George Koskinas published a detailed atlas of the human cerebral cortex, describing a cytoarchitectonic division of the cortical mantle into over 40 distinct areas. Von Economo and Koskinas accompanied their seminal work with large photomicrographic plates of their histological slides, together with tables containing for each described region detailed morphological layer-specific information on neuronal count, neuron size and thickness of the cortical mantle. Here, we aimed to make this legacy data accessible and relatable to in vivo neuroimaging data by constructing a digital Von Economo - Koskinas atlas compatible with the widely used FreeSurfer software suite. In this technical note we describe the procedures used for manual segmentation of the Von Economo - Koskinas atlas onto individual T1 scans and the subsequent construction of the digital atlas. We provide the files needed to run the atlas on new FreeSurfer data, together with some simple code of how to apply the atlas to T1 scans within the FreeSurfer software suite. The digital Von Economo - Koskinas atlas is easily applicable to modern day anatomical MRI data and is made publicly available online. Copyright © 2017 Elsevier Inc. All rights reserved.

QMHC interview: Peter R. Scholtes [by Marie E. Sinioris].

PubMed

Scholtes, P R

1993-01-01

Peter R. Scholtes has a unique perspective on what it takes to build a world-class quality organization: A transformation of the relationships, environment, and dynamics within and between individuals and groups throughout an organization. He brings an organizational development perspective to quality management and, in particular, to the approach and practices advocated by W. Edwards Deming. This interview explores Mr. Scholtes' in-depth understanding and sometimes controversial views on quality improvement teams, team training, and performance appraisal.

[Albert Reder Ritter von Schellmann (1826-1904)].

PubMed

Schmidt, G; Holubar, K

1990-01-01

Albert Reder von Schellmann (1826-1904) was an important syphilidologist of the Vienna Medical School in the second half of the nineteenth century. He went in for the dualistic concept of the origin of syphilis and ulcer caused by soft chancre. In 1870 - Reder became head of a third dermato-syphilidologic department in the "Josephinum" in Vienna, where military surgeons got their medical education. At the same time the two full professorships of dermatosyphilidology in the Vienna General Hospital were held by Ferdinand von Hebra (1816-1880) and Carl Ludwig Sigmund von Ilanor (1810-1883).

Is R. S. Peters' Way of Mentioning Women in His Texts Detrimental to Philosophy of Education? Some Considerations and Questions

ERIC Educational Resources Information Center

Lees, Helen E.

2012-01-01

Discussion in this article considers the unfortunate way R.S. Peters made mention of women when it was pertinent to his argumentation: portraying them, directly or indirectly, as abuse-able (murderable), deficient, aberrant, clueless and inconstant. It is argued that the high profile and esteem within which Peter's texts are held within philosophy…

The Place of Philosophy in the Training of Teachers: Peters Revisited

ERIC Educational Resources Information Center

Clark, John A.

2013-01-01

In 1964, Richard Peters examined the place of philosophy in the training of teachers. He considered three things: Why should philosophy of education be included in the training of teachers; What portion of philosophy of education should be included; How should philosophy be taught to those training to be teachers. This article explores the context…

von Willebrand's disease antigen II. A new plasma and platelet antigen deficient in severe von Willebrand's disease.

PubMed Central

Montgomery, R R; Zimmerman, T S

1978-01-01

Factor VIII-related antigen (VIIIag) is deficient in plasma and platelets of patients with severe von Willebrand's disease. This study reports a second von Willebrand's disease antigen (vWagII), distinct from VIIIag, that is also deficient in the platelets and plasma of patients with severe von Willebrand's disease. VIIIag and vWagII are separable by molecular exclusion chromatography, sucrose density gradient ultracentrifugation, and crossed immunoelectrophoresis. They show reactions of immunologic nonidentity with each other, and thus, do not share a precursor-product relationship. vWagII is released from normal platelets during blood clotting, accounting for a fourfold higher concentration of vWagII in serum over plasma. Images PMID:307007

Instruction in the Making: Peter Ramus and the Beginnings of Modern Schooling.

ERIC Educational Resources Information Center

Hamilton, David

This paper examines educational practice between 1450-1650, highlighting 16th century educationist, Peter Ramus, whose work is remembered in the "History of Western Philosophy" as fostering a "pedagogic marvel." Ramus' work has received scant attention from English-speaking educationists, and his niche within the educational…

Wernher von Braun

NASA Image and Video Library

1962-12-20

Dr. von Braun, Major General Francis McMorrow, and Alabama Governor, John Patterson (far left) participated in the ground breaking ceremony for the University of Alabama Research Institute in Huntsville, December 20, 1962.

Wernher von Braun

NASA Image and Video Library

1965-11-05

In this photograph, Marshall Space Flight Center Director, Dr. Wernher von Braun, presents a Co-Inventor’s award to MSFC employee Martin Hall of the Mechanical Engineering Laboratory during the NASA Anniversary ceremony.

Remaking Critical Pedagogy: Peter McLaren's Contribution to a Collective Work

ERIC Educational Resources Information Center

Martin, Gregory

2006-01-01

This article explores the collective works of Peter McLaren and his contribution to critical pedagogy within the field of education and beyond the academy. To understand how McLaren's work took a radical turn in the 1990s, the article traces the historical development of his praxis. In particular, McLaren's engagement with the postmodern Left and…

Dr. Wernher Von Braun Memorial Dinner

NASA Image and Video Library

2017-10-26

The annual Dr. Wernher Von Braun Memorial Dinner was held at the U.S. Space and Rocket Center's Davidson Center on October 26, 2017 with Keynote speaker General John Hyten, Commander of U.S. Strategic Command. Emcee was Mark Larson of Mark Larson Media Services, Inc. Dr. Wernher Von Braun Memorial Scholarships were presented to 8 college students by the National Space Club. Educator of the Year was awarded to Tammy Thorpe; Community Service award was presented to Huntsville, Al. Mayor Tommy Battle. The Communications Award was presented to retired astronaut Dr. Mike Massimino. The Distinguished Science Award was presented to Dr. Martin Weisskopf. The Astronautics Engineer Award was presented to Douglas R. Cooke. The Dr. Wernher Von Braun Space Flight Trophy was presented to Robert Lightfoot.

Wernher von Braun

NASA Image and Video Library

1967-08-28

Marshall Space Flight Center’s (MSFC) director, Dr. Wernher von Braun (right), inspects a component of a laser experiment being conducted in MSFC’s Space Sciences Laboratory during a tour on August 28, 1967.

Wernher von Braun

NASA Image and Video Library

1962-09-11

Marshall Space Flight Center Director Dr. Wernher von Braun explains a detail from a Saturn IB mockup and engine to President John F. Kennedy, Vice President Lyndon Johnson and other guests, September 11, 1962.

Bewertung von Fahrzeuggeräuschen

NASA Astrophysics Data System (ADS)

Genuit, Klaus; Schulte-Fortkamp, Brigitte; Fiebig, André; Haverkamp, Michael

Bei der Wahrnehmung und Beurteilung eines Automobils sind unzählige Merkmale und Eigenschaften von Bedeutung. Dabei können Merkmale objektiv-technisch beschrieben werden, wie Angaben zur Motorisierung, Höchstgeschwindigkeit, Drehmoment, zulässige Zuladung, Verbrauch usw. Daneben sind weitere Eigenschaften von Bedeutung, die sich einer einfachen objektiv-technischen Beschreibung entziehen. Hier sind Begriffe zu nennen, wie Sicherheit, allgemeine Qualitätsanmutung, Design, Ergonomie, Komfort, Haptik, Fahrdynamik, Zuverlässigkeit, die deutlich schwieriger objektiv erfassbar und beschreibbar sind (Abb. 4.1).

Baron von Zach's business relations with the Munich entrepreneur Joseph von Utzschneider (German Title: Geschäftsbeziehungen des Barons von Zach zu dem Münchner Unternehmer Joseph von Utzschneider)

NASA Astrophysics Data System (ADS)

Schneider, Ivo

The relationship between the astronomer von Zach on the one side and the entrepreneur Joseph von Utzschneider and his partner Georg von Reichenbach on the other dates presumably from the year 1807 when Zach spent two months in Munich. Already in the same year Zach had ordered an instrument for himself and began to solicit business for the institute of Reichenbach, Utzschneider, and Liebherr, which was founded in 1804. One of the clients canvassed by Zach was the director of the observatory in Naples Zuccari. Zuccari had ordered the whole equipment for the new observatory from this institute in 1813. The instruments for Naples, which were completed in 1814, were sent accompanied by Reichenbach by land and sea to their destination where Reichenbach supervised their setup. At that time Reichenbach had separated from Utzschneider who kept the optical institute in Benediktbeuern with his new partner Joseph von Fraunhofer whereas Reichenbach became owner of the mathematical-mechanical institute in Munich. For personal and economical reasons Utzschneider began soon after to produce not only optical glass but also optical devices similar to those offered by Reichenbach. As soon as two institutes in Munich competed against each other on the market for sophisticated geodetical and astronomical instruments Zach sided with Utzschneider. Zach's main professional argument for this decision was that both competitors got the optical glass for their instruments from Utzschneider's optical institute in Benediktbeuern. This meant that Utzschneider had first choice and so the optical part of his instruments could be considered as better than that of Reichenbach`s instruments. Zach's role as an agent in Italy and France for the sale of products coming from Utzschneider's manufactories is highlighted by three of Zach's letters to Utzschneider from 1817 and 1818, two of which are reproduced here for the first time.

Wernher von Braun

NASA Image and Video Library

1962-01-01

Dr. Wernher von Braun, Director of the Marshall Space Flight Center (MSFC), during his tour of the Space information Division of North American Aviation (NAA) in Downey, California, where the Saturn SII stage was developed.

Wernher von Braun

NASA Image and Video Library

1964-10-14

This photograph, dated October 14, 1964, was taken at the Marned Spacecraft Center, now the Johnson Space Center in Houston, Texas. Dr. von Braun is shown looking over consoles in the Manned Spaceflight Control Center.

Implications of R. S. Peters' Notion of "Cognitive Perspective" for Science Education

ERIC Educational Resources Information Center

Hadzigeorgiou, Yannis

2017-01-01

This paper discusses R.S. Peters' notion of "cognitive perspective," which, through careful reading, can be interpreted as a wider perspective resulting from an awareness of the relationships of one's knowledge and understanding to one's own life. This interpretation makes cognitive perspective a holistic notion akin to that of…

"Staying on Task": What Constitutes Classwork in Peter Medway's "Finding a Language"?

ERIC Educational Resources Information Center

Pangilinan, J. P.

2015-01-01

In "Finding a Language", Peter Medway addresses questions of central importance to English teaching--questions of curriculum and of pedagogy. How he addresses these questions provides a sharp contrast to the current orthodoxies of a rigidly prescriptive national curriculum and a closely monitored regime of objective-led, skills-based…

Wernher von Braun

NASA Image and Video Library

1959-03-03

Dr. von Braun, Director of the Development Operations Divisons, and Dr. Debus, Director of the Missile Firing Laboratory; Army Ballistic Missile Agency (ABMA), in the blockhouse during the launch of the Pioneer IV, March 3, 1959.

Rehabilitation: disability ethics versus Peter Singer.

PubMed

McPherson, Gary W; Sobsey, Dick

2003-08-01

This commentary discusses utilitarian bioethics currently articulated by Peter Singer, one of the most widely known bioethicists of the 21st century. His controversial concepts of personhood and replaceability have important implications for people with disabilities, caregivers, and rehabilitation in general. Singer suggests that people with severe disabilities should not be considered persons and therefore have no rights or status in ethical issues. In addition, he argues that, although some people with less severe disabilities qualify as persons, their potential quality of life is significantly compromised by disability and therefore it may be ethically desirable to eliminate them so that their resources can be used for someone with superior potential. We reject these ideas, and suggest that those involved in rehabilitation carefully consider these ideas because they imply that rehabilitation is an immoral act unless it results in full and typical function.

Wernher von Braun

NASA Image and Video Library

1960-11-03

Marshall Space Flight Center’s (MSFC) Director, Dr. Wernher von Braun, is pictured here with Army Ballistic Missile Agency’s (ABMA) Commanding General, J.B. Medaris, before a display of Army missles at the ABMA test lab.

Simulation of ground-water flow in the St. Peter aquifer in an area contaminated by coal-tar derivatives, St. Louis Park, Minnesota. Water Resources Investigation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lorenz, D.L.; Stark, J.R.

1990-01-01

A model constructed to simulate ground-water flow in part of the Prairie du Chien-Jordan and St. Peter aquifers, St. Louis Park, Minnesota, was used to test hypotheses about the movement of ground water contaminated with coal-tar derivatives and to simulate alternatives for reducing the downgradient movement of contamination in the St. Peter aquifer. The model, constructed for a previous study, was applied to simulate the effects of current ground-water withdrawals on the potentiometric surface of the St. Peter aquifer. Model simulations predict that the multiaquifer wells have the potential to limit downgradient migration of contaminants in the St. Peter aquifermore » caused by cones of depression created around the multiaquifer wells. Differences in vertical leakage to the St. Peter aquifer may exist in areas of bedrock valleys. Model simulations indicate that these differences are not likely to affect significantly the general patterns of ground-water flow.« less

14. Photocopy of a photographca. 1902taken by A.W. Peters showing ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

14. Photocopy of a photograph--ca. 1902--taken by A.W. Peters showing Eastwood and his party surveying for the Big Creek Project. The surveying party is visible in the upper right corner. Courtesy Mr. Charles Allan Whitney. - Little Rock Creek Dam, Little Rock Creek, Littlerock, Los Angeles County, CA

The Incompatibility of Punishment and Moral Education: A Reply to Peter Hobson.

ERIC Educational Resources Information Center

Marshall, James D.

1989-01-01

Responds to Peter Hobson's assertions concerning the relationship of punishment and moral education. Draws upon the writings of Michael Foucoult in suggesting that punishment in the legal sense does not fit well with efforts to develop rational autonomy. Suggests that traditional talk of punishment obscures the reality of practice. (KO)

Embracing the Humanistic Vision: Recurrent Themes in Peter Roberts' Recent Writings

ERIC Educational Resources Information Center

Reveley, James

2018-01-01

Running like a leitmotif through Peter Roberts' recently published philosophico-educational writings there is a humanistic thread, which this article picks out. In order to ascertain the quality of this humanism, Roberts is positioned in relation to a pair of extant humanisms: radical and integral. Points of comparability and contrast are…

The Authority of Truth: Religion and the John Peter Zenger Case.

ERIC Educational Resources Information Center

Nord, David Paul

An appreciation of the religious milieu of the John Peter Zenger libel case of 1735 can help explain the nature of the Zenger defense as prepared by Alexander Hamilton, the meaning of the jury's verdict, and the ambiguous legacy of the trial for freedom of expression in the United States. In essence, the case was a disputation on "truth"…

Teaching Behavior Analysis and Psychology in Social Context: An Interview with Peter Harzem.

ERIC Educational Resources Information Center

Buskist, William

2000-01-01

Presents an interview with Peter Harzem, the Hudson Professor of Psychology at Auburn University (Alabama). Addresses such issues as teaching students about behavior analysis, the differences between classical and operant conditioning, reinforcement and behaviorism, and how one can become a better teacher. (CMK)

Childhood Picture of Dr. von Braun

NASA Technical Reports Server (NTRS)

1912-01-01

This is a childhood picture of Dr. von Braun (center) with his brothers. Dr. Wernher von Braun was born in Wirsitz, Germany, March 23, 1912. His childhood dreams of marned space flight were fulfilled when giant Saturn rockets, developed under his direction at NASA's Marshall Space Flight Center, boosted the manned Apollo spacecraft to the Moon. His life was dedicated to expanding man's knowledge through the exploration of space.

Laboratory diagnosis of von Willebrand's disease.

PubMed

Rick, M E

1994-12-01

The diagnosis of von Willebrand's disease is becoming complex as more is understood about the disease. Clinical information and laboratory data are necessary for the diagnosis because of the overlap of normal and abnormal laboratory values. A complete evaluation including von Willebrand factor multimers, ristocetin-induced platelet aggregation, factor VIII activity level, and a template bleeding time is necessary to correctly classify the patient so that optimal treatment may be given.

Wernher von Braun

NASA Image and Video Library

1959-01-01

Marshall Space Flight Center Director Wernher von Braun presents General J.B. Medaris with a new golf bag. General Medaris, (left) was a Commander of the Army Ballistic Missile Agency (ABMA) in Redstone Arsenal, Alabama during 1955 to 1958.

Dr. von Braun Tries Out the NBS

NASA Technical Reports Server (NTRS)

1967-01-01

Marshall Space Flight Center (MSFC) Director, Dr. von Braun, is shown fitted with suit and diving equipment as he prepares for a tryout in the MSFC Neutral Buoyancy Simulator (NBS). Weighted to a neutrally buoyant condition, Dr. von Braun was able to perform tasks underwater which simulated weightless conditions found in space.

Wernher von Braun

NASA Image and Video Library

1950-01-01

Dr. von Braun stands beside a model of the upper stage (Earth-returnable stage) of the three-stage launch vehicle built for the series of the motion picture productions of space flight produced by Walt Disney in the mid-1950's.

Wernher von Braun

NASA Image and Video Library

1959-01-01

In this picture, Dr. Wernher von Braun, who was serving as Director of the Army Ballistic Missile Agency's (ABMA) Development Operations Division, is shown posed with his Mercedes 220SE automobile in front of Redstone Building 4488, which houses the ABMA.

Von Neumann was not a Quantum Bayesian.

PubMed

Stacey, Blake C

2016-05-28

Wikipedia has claimed for over 3 years now that John von Neumann was the 'first quantum Bayesian'. In context, this reads as stating that von Neumann inaugurated QBism, the approach to quantum theory promoted by Fuchs, Mermin and Schack. This essay explores how such a claim is, historically speaking, unsupported. © 2016 The Author(s).

Herstellung von Chitosan und einige Anwendungen

NASA Astrophysics Data System (ADS)

Struszczyk, Marcin Henryk

2001-05-01

1. Die Deacetylierung von crabshell - Chitosan führte gleichzeitig zu einem drastischen Abfall der mittleren viscosimetrischen Molmasse ( Mv), insbesondere wenn die Temperatur und die Konzentration an NaOH erhöht werden. Diese Parameter beeinflussten jedoch nicht den Grad der Deacetylierung (DD). Wichtig ist jedoch die Quelle des Ausgangsmaterials: Chitin aus Pandalus borealis ist ein guter Rohstoff für die Herstellung von Chitosan mit niedrigem DD und gleichzeitig hoher mittlerer Mv, während Krill-Chitin (Euphausia superba) ein gutes Ausgangsmaterial zur Herstellung von Chitosan mit hohem DD und niedrigem Mv ist. Chitosan, das aus Insekten (Calliphora erythrocephala), unter milden Bedingungen (Temperatur: 100°C, NaOH-Konzentration: 40 %, Zeit: 1-2h ) hergestellt wurde, hatte die gleichen Eigenschaften hinsichtlich DD und Mv wie das aus Krill hergestellte Chitosan. Der Bedarf an Zeit, Energie und NaOH ist für die Herstellung von Insekten-Chitosan geringer als für crabshell-Chitosan vergleichbare Resultaten für DD und Mv. 2. Chitosan wurde durch den Schimmelpilz Aspergillus fumigatus zu Chitooligomeren fermentiert. Die Ausbeute beträgt 25%. Die Chitooligomere wurden mit Hilfe von HPLC und MALDI-TOF-Massenspektrmetrie identifiziert. Die Fermentationsmischung fördert die Immunität von Pflanzen gegen Bakterien und Virusinfektion. Die Zunahme der Immunität schwankt jedoch je nach System Pflanze-Pathogen. Die Fermentation von Chitosan durch Aspergillus fumigatus könnte eine schnelle und billige Methode zur Herstellung von Chitooligomeren mit guter Reinheit und Ausbeute sein. Eine partiell aufgereinigte Fermentationsmischung dieser Art könnte in der Landwirtschaft als Pathogeninhibitor genutzt werden. Durch kontrollierte Fermentation, die Chitooligomere in definierter Zusammensetzung (d.h. definierter Verteilung des Depolymerisationsgrades) liefert, könnte man zu Mischungen kommen, die für die jeweilige Anwendung eine optimale Bioaktivität besitzen. 3

STS-81 Mission Specialist Peter Wisoff suits up

NASA Technical Reports Server (NTRS)

1997-01-01

STS-81 Mission Specialist Peter J. K. 'Jeff' Wisoff prepares for the fifth Shuttle- Mir docking as he waits in the Operations and Checkout (O&C) Building for the operation to fit him into his launch/entry suit to be completed. He conducted a spacewalk on his on his first Shuttle mission, STS- 57 and holds a doctorate degree in applied physics with an emphasis on lasers and semiconductor materials. He and five crew members will shortly depart the O&C and head for Launch Pad 39B, where the Space Shuttle Atlantis will lift off during a 7-minute window that opens at 4:27 a.m. EST, January 12.

Communicating Chemistry from "Molecules" to International Efforts: An Interview with Peter Atkins

ERIC Educational Resources Information Center

Cardellini, Liberato

2008-01-01

In this interview, Peter Atkins explains the deep motivations that compel him to sit at his desk at 6 AM writing books and textbooks. He discusses the four principal elements that help to make a chemistry textbook successful, including the secret ingredient. He also discusses the importance of problem solving, the interaction of multimedia, and…

How Relevant Is R. S. Peters' Conception of Education to Science Education?

ERIC Educational Resources Information Center

Hadzigeorgiou, Yannis; Stamatis, Panagiotis

2017-01-01

This paper discusses R. S. Peters' concept of education, particularly his notion of cognitive perspective and its relevance to school science education. In light of the problems inherent in any attempt to define the notion of scientific literacy, it is argued that the development of cognitive perspective can be considered an important, if not the…

Respectability and Relevance: Reflections on Richard Peters and Analytic Philosophy of Education

ERIC Educational Resources Information Center

Snook, Ivan

2013-01-01

I argue that, after Dewey, Peters was the first modern philosopher of education to write material (in English) that was both philosophically respectable and relevant to the day-to-day concerns of teachers. Since then, some philosophers of education have remained (more or less) relevant but not really respectable while others have "taken off into…

R. S. Peters and J. H. Newman on the Aims of Education

ERIC Educational Resources Information Center

Ozolins, Janis T.

2013-01-01

R. S. Peters never explicitly talks about wisdom as being an aim of education. He does, however, in numerous places, emphasize that education is of the whole person and that, whatever else it might be about, it involves the development of knowledge and understanding. Being educated, he claims, is incompatible with being narrowly specialized.…

Travels with Chairman of the Joint Chiefs of Staff, Marine General Peter

Science.gov Websites

that time. Story Counter-drug Efforts May Aid Afghanistan BOGOTA, Colombia, Jan. 20, 2007 – The long experience in its counter-drug effort to help the Afghan government fight a similar battle. " has working the counter-drug (issue)," Marine Gen. Peter Pace said. "It's been a very

Reason and Virtues: The Paradox of R. S. Peters on Moral Education

ERIC Educational Resources Information Center

Haydon, Graham

2009-01-01

This article examines the work of R. S. Peters on moral development and moral education, as represented in his papers collected under that name, pointing out that these writings have been relatively neglected. It approaches these writings through the lens of the "familiar story" that philosophical work on this topic switched during, roughly, the…

Critically Enlightened Romantic Values and English Pedagogy: A Response to Peter Medway

ERIC Educational Resources Information Center

Stevens, David

2011-01-01

In this response to Peter Medway's paper, "English and Enlightenment' (Changing English 17:1, 2010), I take issue with little of what he so lucidly writes, except his implicit and occasionally explicit denunciation of Romanticism as the proper basis of English pedagogy. I am concerned in this paper to emphasise the positive aspects of…

Locally Compact Quantum Groups. A von Neumann Algebra Approach

NASA Astrophysics Data System (ADS)

Van Daele, Alfons

2014-08-01

In this paper, we give an alternative approach to the theory of locally compact quantum groups, as developed by Kustermans and Vaes. We start with a von Neumann algebra and a comultiplication on this von Neumann algebra. We assume that there exist faithful left and right Haar weights. Then we develop the theory within this von Neumann algebra setting. In [Math. Scand. 92 (2003), 68-92] locally compact quantum groups are also studied in the von Neumann algebraic context. This approach is independent of the original C^*-algebraic approach in the sense that the earlier results are not used. However, this paper is not really independent because for many proofs, the reader is referred to the original paper where the C^*-version is developed. In this paper, we give a completely self-contained approach. Moreover, at various points, we do things differently. We have a different treatment of the antipode. It is similar to the original treatment in [Ann. Sci. & #201;cole Norm. Sup. (4) 33 (2000), 837-934]. But together with the fact that we work in the von Neumann algebra framework, it allows us to use an idea from [Rev. Roumaine Math. Pures Appl. 21 (1976), 1411-1449] to obtain the uniqueness of the Haar weights in an early stage. We take advantage of this fact when deriving the other main results in the theory. We also give a slightly different approach to duality. Finally, we collect, in a systematic way, several important formulas. In an appendix, we indicate very briefly how the C^*-approach and the von Neumann algebra approach eventually yield the same objects. The passage from the von Neumann algebra setting to the C^*-algebra setting is more or less standard. For the other direction, we use a new method. It is based on the observation that the Haar weights on the C^*-algebra extend to weights on the double dual with central support and that all these supports are the same. Of course, we get the von Neumann algebra by cutting down the double dual with this unique

Dr. von Braun and Army Ballistics Missile Agency (ABMA) Group

NASA Technical Reports Server (NTRS)

1959-01-01

This photograph of Dr. von Braun, shown here to the left of General Bruce Medaris, was taken in the fall of 1959, immediately prior to Medaris' retirement from the Army. At the time, von Braun and his associates worked for the Army Ballistics Missile Agency in Huntsville, Alabama. Those in the photograph have been identified as Ernst Stuhlinger, Frederick von Saurma, Fritz Mueller, Hermarn Weidner, E.W. Neubert (partially hidden), W.A. Mrazek, Karl Heimburg, Arthur Rudolph, Otto Hoberg, von Braun, Oswald Lange, Medaris, Helmut Hoelzer, Hans Maus, E.D. Geissler, Hans Heuter, and George Constan.

Shrinking the Civil-Military Divide: A Military Perspective

DTIC Science & Technology

2015-04-13

2011), 1. 2 Carl von Clausewitz, On War, eds. and trans. Michael Howard and Peter Paret (New York: Alfred A. Knopf, 1976), 101. EXTERNAL...his seminal study of warfare, Carl von Clausewitz defined war as a trinity of three interacting forces—passion, reason, and chance.1 To embody these...was Africa-American. Campbell Gibson and Kay Jung . Historical Census Statistics on Population Totals by Race, 1790 to 1990, and by Hispanic Origin

The Bundeswehr in the 21st Century - Between Prussia’s Glory and Design

DTIC Science & Technology

2011-05-19

Berlin: 2010). 3 and later active member in the group of reformers, Carl von Clausewitz.3 This spirit found its expression in Clausewitz’s most notable...1801-1805 (Westport, Connecticut: Praeger Publishers, 1989), 101. 4 Carl von Clausewitz, On War, trans. and ed. Michael Howard and Peter Paret...für junge Offiziere (Academy for Young Officers) and the Militärische Gesellschaft (Military Society) both located in Berlin. Within three years

Re-Examining the Roles of Landpower in the 21st Century and Their Implications

DTIC Science & Technology

2014-11-01

period, therefore, would have held its own theory of war… Carl von Clausewitz, On War1 Landpower is the ability—by threat, force, or occupa- tion—to...integration and synchronization of all ele- ments of military power can generate overwhelming combat power. Once the insurgency broke out after U.S. military...of military power, such decisions never come easy. ENDNOTES 1. Carl von Clausewitz, On War, Michael Howard and Peter Paret, eds. and trans

Color constancy: enhancing von Kries adaption via sensor transformations

NASA Astrophysics Data System (ADS)

Finlayson, Graham D.; Drew, Mark S.; Funt, Brian V.

1993-09-01

Von Kries adaptation has long been considered a reasonable vehicle for color constancy. Since the color constancy performance attainable via the von Kries rule strongly depends on the spectral response characteristics of the human cones, we consider the possibility of enhancing von Kries performance by constructing new `sensors' as linear combinations of the fixed cone sensitivity functions. We show that if surface reflectances are well-modeled by 3 basis functions and illuminants by 2 basis functions then there exists a set of new sensors for which von Kries adaptation can yield perfect color constancy. These new sensors can (like the cones) be described as long-, medium-, and short-wave sensitive; however, both the new long- and medium-wave sensors have sharpened sensitivities -- their support is more concentrated. The new short-wave sensor remains relatively unchanged. A similar sharpening of cone sensitivities has previously been observed in test and field spectral sensitivities measured for the human eye. We present simulation results demonstrating improved von Kries performance using the new sensors even when the restrictions on the illumination and reflectance are relaxed.

Dr. von Braun With Management Team

NASA Technical Reports Server (NTRS)

1961-01-01

Dr. von Braun is shown in this photograph, which was probably taken in the early 1960s, with members of his management team. Pictured from left to right are, Werner Kuers, Director of the Manufacturing Engineering Division; Dr. Walter Haeussermarn, Director of the Astrionics Division; Dr. William Mrazek, Propulsion and Vehicle Engineering Division; Dr. von Braun; Dieter Grau, Director of the Quality Assurance Division; Dr. Oswald Lange, Director of the Saturn Systems Office; and Erich Neubert , Associate Deputy Director for Research and Development.

Portrait of Dr. Von Braun with Walt Disney, 1954.

NASA Technical Reports Server (NTRS)

1954-01-01

Marshall Center Director Dr. Wernher Von Braun is pictured with Walt Disney during a visit to the Marshall Space Flight Center in 1954. In the 1950s, Dr. Von Braun while working in California on the Saturn project, also worked with Disney studios as a technical director in making three films about Space Exploration for television. Disney's tour of Marshall in 1965 was Von Braun's hope for a renewed public interest in the future of the Space Program at NASA.

Alexander von Humboldt and the concept of animal electricity.

PubMed

Kettenmann, H

1997-06-01

More than two hundred years ago, Alexander von Humboldt helped to establish Galvani's view that muscle and nerve tissue are electrically excitable. His 1797 publication was a landmark for establishing the concept of animal electricity. Almost half a century later, von Humboldt became the mentor of the young du Bois-Reymond. With the help of von Humboldt's promotion, du Bois-Reymond demonstrated convincingly that animal tissue has the intrinsic capacity to generate electrical activity, and thus laid the ground for modern electrophysiology.

United Nations Intervention for Humanitarian Relief in Bosnia- Herzegovina

DTIC Science & Technology

1993-02-22

govinan Corps I i~leca) 5th Mixed A.dr Peql ath Motorized Ode 149ithIME-dium AA Arty Regt’ (SA-6) 13th Motor- zeC Mde 5th Light A-A Arty Regt `145th...34 1. Carl Von Clausewitz, On War, Translated and Edited by Michael Howard and Peter Paret, (Princeton: Princeton University Press), p. 579. 2...Michael Howard and Peter Paret, Princeton: Princeton University Press, 1976. Cohen, Leonard J. "The Disintegration of Yugoslavia", Current History

Dr. von Braun With German Rocket Experimenters

NASA Technical Reports Server (NTRS)

1930-01-01

Dr. von Braun was among a famous group of rocket experimenters in Germany in the 1930s. This photograph is believed to be made on the occasion of Herman Oberth's Kegelduese liquid rocket engine being certified as to performance during firing. From left to right are R. Nebel, Dr. Ritter, Mr. Baermueller, Kurt Heinish, Herman Oberth, Klaus Riedel, Wernher von Braun, and an unidentified person.

John P. Peters and the committee of 430 physicians.

PubMed Central

Lundberg, George D.

2002-01-01

John Peters and his committee had a few basic goals. One was that local, state, and federal governments needed to provide money to construct facilities, support medical research and education, and care for the poor. And they wanted experts to call the shots. Over time, Peters and the committee got what they wanted for the most part: Hill-Burton money for building the hospitals, the rise of the National Institutes of Health, Medicare, Medicaid, a Veterans Administration system, and new and expanded medical schools. The experts calling the shots included David Kessler at the Food and Drug Administration and Surgeon General C. Everett Koop. In the halcyon days of American health system reform, back in 1993, Yale's Paul Beeson wrote about the Committee of 430 Physicians and its goals in the Pharos of Alpha Omega Alpha. Beeson was optimistic and he quoted from my 1991 JAMA health system reform editorial as a sharp contrast to what Fishbein had written - although coincidentally, we both quote Lincoln. My editorial began, "'with malice toward none, with charity for all...' so spoke Abraham Lincoln in his second inaugural address recognizing that he had no political consensus regarding either the constitutionality of states seceding or the morality of slavery being abolished. Nonetheless, he knew what was right and was able, through persuasive, often inspiring rhetoric, to conclude a bloody and decisive Civil War and constitute the foundation for this great republic.... Yet access to basic medical care for all of our inhabitants is still not a reality in this country. There are many reasons for this, not the least of which is a long-standing, systematic, institutionalized racial discrimination.... An aura of inevitablitiy is upon us. It is not acceptable morally, ethically, or economically for so many of our people to be medically uninsured or seriously underinsured. We can solve this problem. We have the knowledge and the resources, the skills, the time, and the moral

John P. Peters and the committee of 430 physicians.

PubMed

Lundberg, George D

2002-01-01

John Peters and his committee had a few basic goals. One was that local, state, and federal governments needed to provide money to construct facilities, support medical research and education, and care for the poor. And they wanted experts to call the shots. Over time, Peters and the committee got what they wanted for the most part: Hill-Burton money for building the hospitals, the rise of the National Institutes of Health, Medicare, Medicaid, a Veterans Administration system, and new and expanded medical schools. The experts calling the shots included David Kessler at the Food and Drug Administration and Surgeon General C. Everett Koop. In the halcyon days of American health system reform, back in 1993, Yale's Paul Beeson wrote about the Committee of 430 Physicians and its goals in the Pharos of Alpha Omega Alpha. Beeson was optimistic and he quoted from my 1991 JAMA health system reform editorial as a sharp contrast to what Fishbein had written - although coincidentally, we both quote Lincoln. My editorial began, "'with malice toward none, with charity for all...' so spoke Abraham Lincoln in his second inaugural address recognizing that he had no political consensus regarding either the constitutionality of states seceding or the morality of slavery being abolished. Nonetheless, he knew what was right and was able, through persuasive, often inspiring rhetoric, to conclude a bloody and decisive Civil War and constitute the foundation for this great republic.... Yet access to basic medical care for all of our inhabitants is still not a reality in this country. There are many reasons for this, not the least of which is a long-standing, systematic, institutionalized racial discrimination.... An aura of inevitablitiy is upon us. It is not acceptable morally, ethically, or economically for so many of our people to be medically uninsured or seriously underinsured. We can solve this problem. We have the knowledge and the resources, the skills, the time, and the moral

Von Neumann's impossibility proof: Mathematics in the service of rhetorics

NASA Astrophysics Data System (ADS)

Dieks, Dennis

2017-11-01

According to what has become a standard history of quantum mechanics, in 1932 von Neumann persuaded the physics community that hidden variables are impossible as a matter of principle, after which leading proponents of the Copenhagen interpretation put the situation to good use by arguing that the completeness of quantum mechanics was undeniable. This state of affairs lasted, so the story continues, until Bell in 1966 exposed von Neumann's proof as obviously wrong. The realization that von Neumann's proof was fallacious then rehabilitated hidden variables and made serious foundational research possible again. It is often added in recent accounts that von Neumann's error had been spotted almost immediately by Grete Hermann, but that her discovery was of no effect due to the dominant Copenhagen Zeitgeist. We shall attempt to tell a story that is more historically accurate and less ideologically charged. Most importantly, von Neumann never claimed to have shown the impossibility of hidden variables tout court, but argued that hidden-variable theories must possess a structure that deviates fundamentally from that of quantum mechanics. Both Hermann and Bell appear to have missed this point; moreover, both raised unjustified technical objections to the proof. Von Neumann's argument was basically that hidden-variables schemes must violate the ;quantum principle; that physical quantities are to be represented by operators in a Hilbert space. As a consequence, hidden-variables schemes, though possible in principle, necessarily exhibit a certain kind of contextuality. As we shall illustrate, early reactions to Bohm's theory are in agreement with this account. Leading physicists pointed out that Bohm's theory has the strange feature that pre-existing particle properties do not generally reveal themselves in measurements, in accordance with von Neumann's result. They did not conclude that the ;impossible was done; and that von Neumann had been shown wrong.

Wernher von Braun

NASA Image and Video Library

1964-10-14

This photograph is dated October 14, 1964, and shows Dr. von Braun, left, during a tour of the NASA Marned Spacecraft Center, now the Johnson Space Center. He is with Dr. J.P. Kuettner, center, from the Marshall Space Flight Center, and Warren J. North from the Manned Spacecraft Center.

Dr. von Braun with Seven Original Mercury Astronauts

NASA Technical Reports Server (NTRS)

1959-01-01

In this photo, Dr. Wernher von Braun, Director of the U.S. Army Ballistic Missile Agency's (ABMA) Development Operations Division, is shown briefing the seven original Mercury astronauts in ABMA's Fabrication Laboratory. (Left to right) Guss Grissom, Walter Schirra, Alan Shepard, John Glenn, Scott Carpenter, Gordon Cooper, Donald Slayton, and Dr. von Braun.

Ein Konzept für den energieeffizienten Betrieb von Mobilfunknetzen

NASA Astrophysics Data System (ADS)

Bayer, N.; von Hugo, D.

2015-11-01

Der flächendeckende Betrieb mehrerer Mobilfunknetze unterschiedlicher Technologie in einem Land sorgt aufgrund der ständigen Bereithaltung von Übertragungskapazität für Dienste mit zunehmend höherem Datenvolumenbedarf für einen erheblichen Energieverbrauch. Das Forschungsförderungsprojekt ComGreen hat sich zur Aufgabe gesetzt, durch lastadaptiven Betrieb und intelligente dynamische Rekonfiguration des Funkzugangsnetzes zur Energieeinsparung beizutragen. Konzept, Herausforderungen, ausgewählte Ergebnisse von Simulationen und prototypischem Betrieb werden ebenso wie typische Erwartungswerte des künftigen Energieverbrauchs im Mobilfunkbereich vorgestellt. Sowohl Berechnungen als auch Messungen zeigen, dass durch kontext-basierte dynamische Rekonfiguration von zellularen Funknetzen Energieeinsparungen im Bereich von 25-40 % ermöglicht werden.

Pilot Peter Hoag and HL-10

NASA Technical Reports Server (NTRS)

1969-01-01

Air Force Major Peter Hoag stands in front of the HL-10 Lifting Body. Maj. Hoag joined the HL-10 program in 1969 and made his first glide flight on June 6, 1969. He made a total of 8 flights in the HL-10. They included the fastest lifting-body flight, which reached Mach 1.861 on Feb. 18, 1970. The HL-10 was one of five heavyweight lifting-body designs flown at NASA's Flight Research Center (FRC--later Dryden Flight Research Center), Edwards, California, from July 1966 to November 1975 to study and validate the concept of safely maneuvering and landing a low lift-over-drag vehicle designed for reentry from space. Northrop Corporation built the HL-10 and M2-F2, the first two of the fleet of 'heavy' lifting bodies flown by the NASA Flight Research Center. The contract for construction of the HL-10 and the M2-F2 was $1.8 million. 'HL' stands for horizontal landing, and '10' refers to the tenth design studied by engineers at NASA's Langley Research Center, Hampton, Va. After delivery to NASA in January 1966, the HL-10 made its first flight on Dec. 22, 1966, with research pilot Bruce Peterson in the cockpit. Although an XLR-11 rocket engine was installed in the vehicle, the first 11 drop flights from the B-52 launch aircraft were powerless glide flights to assess handling qualities, stability, and control. In the end, the HL-10 was judged to be the best handling of the three original heavy-weight lifting bodies (M2-F2/F3, HL-10, X-24A). The HL-10 was flown 37 times during the lifting body research program and logged the highest altitude and fastest speed in the Lifting Body program. On Feb. 18, 1970, Air Force test pilot Peter Hoag piloted the HL-10 to Mach 1.86 (1,228 mph). Nine days later, NASA pilot Bill Dana flew the vehicle to 90,030 feet, which became the highest altitude reached in the program. Some new and different lessons were learned through the successful flight testing of the HL-10. These lessons, when combined with information from it's sister ship, the M2

The Russo-Japanese War, Lessons Not Learned

DTIC Science & Technology

2003-05-06

USACGSC, August, 2002), CR3.7-1--CR3.7-14; Michael Howard , “Men Against Fire, Expectations of War in 1914,” International Security (Summer 1984): 41-57...169; Carl von Clausewitz, On War, trans. and ed. Michael Howard and Peter Paret (Princeton: Princeton University Press, 1984), 37-38. 8Service in...Cleator, P. Weapons of War. New York: Thomas Y. Crowell Company, 1967. Clausewitz, Carl von. On War. Edited and translated by Michael Howard and

Wernher von Braun

NASA Image and Video Library

1959-03-04

Dr. Wernher von Braun, Director of the U.S. Army Ballistic Missile Agency's (ABMA) Development Operations Division, talks to Huntsville Mayor R. B. "Speck" Searcy, center, and Army Ordnance Missile Command (ARMC) Major General John B. Medaris, right, during "Moon Day" celebrations in downtown Huntsville, Alabama. (Courtesy of Huntsville/Madison County Public Library)

Wernher von Braun

NASA Image and Video Library

1965-05-25

In this photo, Dr. von Braun anxiously awaits the launch of the Saturn I vehicle (SA-8) in the Launch Complex Control Center at the Kennedy Space Center in Florida on May 25, 1965. The SA-8 mission made the first night launch and deployed the Pegasus II micro meteoroid detection satellite.

[Questions on the first operation with ethyl ether as anaesthetic by Dr. Peter Parker].

PubMed

Chen, Q

2017-01-28

Ethyl ether was the first accepted effective general anaesthetic. It was introduced into China by an America missionary, Dr. Peter Parker. This was one of the historical events of medical communication between China and the West. In the records of the first operation with ether, however, Dr. Parker unusually omitted the patient's medical record number and the date of the operation, while those of other operations with ether anesthetics were all available. This was very unusual for a doctor like Peter Parker who always recorded every important case in detail in the hospital reports. It seems that he deliberately rather than carelessly omitted the information for some reasons. Based on the analysis of Parker's reports, a conclusion is made that the anesthetic effect of the case was actually ineffective. Furthermore, possible answers to this are outlined and question by discussion based on the situation that Parker faced in the late Qing era.

Formulating an Anarchist Sociology: Peter Kropotkin's Reading of Herbert Spencer.

PubMed

Adams, Matthew S

2016-01-01

The work of Herbert Spencer was a crucial influence on the development of Peter Kropotkin's historical sociology. However, scholars have underestimated this relationship; either overlooking it entirely, or minimizing Kropotkin's attachment to Spencer with the aim of maintaining the utility of his political thought in the present. This article contests these interpretations by analyzing Kropotkin's reading of Spencer's epistemological, biological, and political ideas. It argues that Kropotkin was engaged in a critical dialogue with Spencer, incorporating many Spencerian principles in his own system, but also using this reading to articulate a distinctive anarchist politics.

Dr. von Braun with Original Mercury Astronauts

NASA Technical Reports Server (NTRS)

1959-01-01

Dr. Wernher von Braun, Director of the Army Ballistic Missile Agency's (ABMA) Development Operations Division, poses with the original Mercury astronauts in ABMA's Fabrication Laboratory during a 1959 visit. Inspecting Mercury-Redstone hardware are from left to right, Alan Shepard, Donald Deke Slayton, Virgil Gus Grissom, von Braun, Gordon Cooper, Wally Schirra, John Glenn, and Scott Carpenter. Project Mercury officially began October 7, 1958 as the United States' first manned space program.

Platelet-independent adhesion of calcium-loaded erythrocytes to von Willebrand factor

PubMed Central

Bierings, Ruben; Meems, Henriet; Mul, Frederik P. J.; Geerts, Dirk; Vlaar, Alexander P. J.; Voorberg, Jan; Hordijk, Peter L.

2017-01-01

Adhesion of erythrocytes to endothelial cells lining the vascular wall can cause vaso-occlusive events that impair blood flow which in turn may result in ischemia and tissue damage. Adhesion of erythrocytes to vascular endothelial cells has been described in multiple hemolytic disorders, especially in sickle cell disease, but the adhesion of normal erythrocytes to endothelial cells has hardly been described. It was shown that calcium-loaded erythrocytes can adhere to endothelial cells. Because sickle erythrocyte adhesion to ECs can be enhanced by ultra-large von Willebrand factor multimers, we investigated whether calcium loading of erythrocytes could promote binding to endothelial cells via ultra-large von Willebrand factor multimers. We used (immunofluorescent) live-cell imaging of washed erythrocytes perfused over primary endothelial cells at venular flow rate. Using this approach, we show that calcium-loaded erythrocytes strongly adhere to histamine-stimulated primary human endothelial cells. This adhesion is mediated by ultra-large von Willebrand factor multimers. Von Willebrand factor knockdown or ADAMTS13 cleavage abolished the binding of erythrocytes to activated endothelial cells under flow. Platelet depletion did not interfere with erythrocyte binding to von Willebrand factor. Our results reveal platelet-independent adhesion of calcium-loaded erythrocytes to endothelium-derived von Willebrand factor. Erythrocyte adhesion to von Willebrand factor may be particularly relevant for venous thrombosis, which is characterized by the formation of erythrocyte-rich thrombi. PMID:28249049

Wernher von Braun

NASA Image and Video Library

1965-04-13

Walt Disney toured the West Test Area during his visit to the Marshall Space Flight Center on April 13, 1965. The three in center foreground are Karl Heimburg, Director, Test Division; Dr. von Braun, Director, MSFC; and Walt Disney. The Dynamic Test Stand with the S-1C stage being installed is in the background.

Wernher von Braun

NASA Image and Video Library

1961-10-19

Dr. Wernher von Braun holds the coveted Hermarn Oberth award presented to him by Professor Oberth during the banquet hosted by the Alabama Section of the American Rocket Society (ARS), on October 19, 1961. The Oberth award was given for outstanding technical contributions to the field of astronautics or for the promotion and advancement of astronautical sciences.

A Critique of Peter Jarvis's Conceptualisation of the Lifelong Learner in the Contemporary Cultural Context

ERIC Educational Resources Information Center

Bagnall, Richard G.

2017-01-01

This paper examines Peter Jarvis's conceptualisation of lifelong learners, who are seen as being the individual products of their learning engagements, constrained by their individual biological potentials. They are presented as seeking existentially authentic resolution to dialectically oppositional disjunctures between their individual…

Dr. von Braun With Five of the Original Astronauts

NASA Technical Reports Server (NTRS)

1959-01-01

Five of the seven original astronauts are seen with Dr. von Braun inspecting the Mercury-Redstone hardware in the Fabrication Laboratory of Army Ballistic Missile Agency (ABMA) in 1959. Left to right: Astronauts Walter Schirra, Alan Shepard, John Glenn, Scott Carpenter, Gordon Cooper, and Dr. von Braun.

Von Kármán between Aachen and Pasadena

NASA Astrophysics Data System (ADS)

Krause, Egon; Kalkmann, Ulrich

2013-05-01

In the Introduction the reader is referred back to the academic ceremonials held after Theodore von Kármán's death in Aachen in May 1963. His work as the first director of the Aerodynamisches Institut (Institute of Aerodynamics) of the RWTH Aachen University of Technology from 1913 on and his initiative to re-establish international cooperation after World War I, resulting in the International Union of Theoretical and Applied Mechanics (IUTAM), are commented on. The following chapter describes von Kármán's relation to his former teacher Ludwig Prandtl. Some of von Kármán's scientific contributions during his time in Aachen are briefly reviewed. Thereafter, his first contacts to the California Institute of Technology are covered. Finally, the scientific and political circumstances, which led to von Kármán's decision to leave Germany in the early thirties, are elucidated in some detail. The English translation of the titles of the Aachen papers is given in Appendix I.

Mittelwert- und Arbeitstaktsynchrone Simulation von Dieselmotoren

NASA Astrophysics Data System (ADS)

Zahn, Sebastian

Getrieben durch die immer restriktiveren Anforderungen an das Emissions- und Verbrauchsverhalten moderner Verbrennungsmotoren steigt die Komplexität von Motormanagementsystemen mit jeder Modellgeneration an. Damit geht nicht nur eine Zunahme des Softwareumfangs von Steuergeräten sondern zugleich ein deutlicher Anstieg des Applikations-, Vermessungs- und Testaufwandes einher. Zur Effizienzsteigerung des Software- und Funktionsentwicklungsprozesses haben sich daher in der Automobilindustrie sowie in Forschungsinstituten verschiedene modell- und simulationsbasierte Methoden wie die Model-in-the-Loop (MiL) Simulation, die Software-in-the-Loop (SiL) Simulation, das Rapid Control Prototyping (RCP) sowie die Hardware-in-the-Loop (HiL) Simulation etabliert.

von Braun and German Publisher

NASA Technical Reports Server (NTRS)

1969-01-01

In this photograph, Guenter Ogger of Capitol Magazine, West Germany, greets Marshall Space Flight Center Director, Dr. Wernher von Braun. Mr. Ogger interviewed the famous rocket scientist for his magazine.

Eine selbstkonsistente Carleman Linearisierung zur Analyse von Oszillatoren

NASA Astrophysics Data System (ADS)

Weber, Harry; Mathis, Wolfgang

2017-09-01

Die Analyse nichtlinearer dynamischer Schaltungen ist bis heute eine herausfordernde Aufgabe, da nur selten analytische Lösungen angegeben werden können. Daher wurden eine Vielzahl von Methoden entwickelt, um eine qualitative oder quantitative Näherung für die Lösungen der Netzwerkgleichung zu erhalten. Oftmals wird beispielsweise eine Kleinsignalanalyse mit Hilfe einer Taylorreihe in einem Arbeitspunkt durchgeführt, die nach den Gliedern erster Ordnung abgebrochen wird. Allerdings ist diese Linearisierung nur in der Nähe des stabilen Arbeitspunktes für hyperbolische Systeme gültig. Besonders für die Analyse des dynamischen Verhaltens von Oszillatoren treten jedoch nicht-hyperbolische Systeme auf, sodass diese Methode nicht angewendet werden kann Mathis (2000). Carleman hat gezeigt, dass nichtlineare Differentialgleichungen mit polynomiellen Nichtlinearitäten in ein unendliches System von linearen Differentialgleichungen transformiert werden können Carleman (1932). Wird das unendlichdimensionale Gleichungssystem für numerische Zwecke abgebrochen, kann bei Oszillatoren der Übergang in eine stationäre Schwingung (Grenzzyklus) nicht wiedergegeben werden. In diesem Beitrag wird eine selbstkonsistente Carleman Linearisierung zur Untersuchung von Oszillatoren vorgestellt, die auch dann anwendbar ist, wenn die Nichtlinearitäten keinen Polynomen entsprechen. Anstelle einer linearen Näherung um einen Arbeitspunkt, erfolgt mit Hilfe der Carleman Linearisierung eine Approximation auf einem vorgegebenen Gebiet. Da es jedoch mit der selbstkonsistenten Technik nicht möglich ist, das stationäre Verhalten von Oszillatoren zu beschreiben, wird die Berechnung einer Poincaré-Abbildung durchgeführt. Mit dieser ist eine anschließende Analyse des Oszillators möglich.

Interview with Peter Samis and Mimi Michaelson, Authors of "Creating the Visitor-Centered Museum"

ERIC Educational Resources Information Center

Spero, Susan

2017-01-01

"Creating the Visitor-Centered Museum" offers insight into why and how 10 case study museums have transformed to serve the needs of their public. Susan Spero interviews authors Peter Samis and Mimi Michaelson about the purpose of the book, their case study choices, the key characteristics of visitor-centered institutions and their…

Two Is the Beginning of the End: "Peter Pan" and the Doctrine of Reminiscence

ERIC Educational Resources Information Center

Hudson, Glenda A.

2006-01-01

This article considers J.M. Barrie's satirical treatment of the Platonic doctrine of reminiscence in "Peter Pan," and how Barrie's work both honors and undercuts it. It will first analyze the Platonic notion of the doctrine of reminiscence in Wordsworth's "Ode: Intimations of Immortality from Recollections of Early Childhood" (1807). It will then…

"Operating on a Basis of Student Consent": Peter Medway's Work in "Finding a Language"

ERIC Educational Resources Information Center

Burgess, Tony

2015-01-01

Written nearly 40 years ago, Peter Medway's "Finding a Language" continues to be an arresting read, which offers a powerful vision of what might be possible in education. In this brief introduction, I set the work in context, referring to ideas that Pete engaged with and recalling a little of the times.

Monte Carlo turbulence simulation using rational approximations to von Karman spectra

NASA Technical Reports Server (NTRS)

Campbell, C. W.

1986-01-01

Turbulence simulation is computationally much simpler using rational spectra, but turbulence falls off as f exp -5/3 in frequency ranges of interest to aircraft response and as predicted by von Karman's model. Rational approximations to von Karman spectra should satisfy three requirements: (1) the rational spectra should provide a good approximation to the von Karman spectra in the frequency range of interest; (2) for stability, the resulting rational transfer function should have all its poles in the left half-plane; and (3) at high frequencies, the rational spectra must fall off as an integer power of frequency, and since the -2 power is closest to the -5/3 power, the rational approximation should roll off as the -2 power at high frequencies. Rational approximations to von Karman spectra that satisfy these three criteria are presented, along with spectra from simulated turbulence. Agreement between the spectra of the simulated turbulence and von Karman spectra is excellent.

Wernher von Braun

NASA Image and Video Library

1959-01-21

In this photo, (left to right) Army Ballistic Missile Agency (ABMA) Missile Firing Laboratory Chief Dr. Kurt Debus, Director of the ABMA Development Operations Division, Dr. von Braun and an unidentified individual in blockhouse during the CM-21 (Jupiter) firing. The Jupiter missile CM-21 became the first Chrysler production qualification missile to be fired and in March 1959 launched the Pioneer IV.

Von Karman Vortices

NASA Image and Video Library

2017-12-08

July 4th, 2002: Description: As air flows over and around objects in its path, spiraling eddies, known as Von Karman vortices, may form. The vortices in this image were created when prevailing winds sweeping east across the northern Pacific Ocean encountered Alaska’s Aleutian Islands. Source: Landsat 7 To learn more about the Landsat satellite go to: landsat.gsfc.nasa.gov/

Wernher von Braun

NASA Image and Video Library

1954-07-01

Dr. Wernher von Braun (center), then Chief of the Guided Missile Development Division at Redstone Arsenal, Alabama, discusses a "bottle suit" model with Dr. Heinz Haber (left), an expert on aviation medicine, and Willey Ley, a science writer on rocketry and space exploration. The three men were at the Disney studios appearing in the motion picture, entitled "Man in Space."

[Peter of Abano, the 'Conciliator' between magic and science].

PubMed

Federici Vescovini, Graziella

2008-01-01

Peter of Abano is a personage belonging to history as well as to legend. In this analysis his historical physiognomy of scientist and physician is reconstructed on the basis of a better knowledge of his works in medicine and astronomy (now edited), a discipline, the latest one, in which he excelled in Medieval scientific context (The Lucidator dubitabilium astronomiae (astrologiae) can be read in the critical edition by G. Federici Vescovini, Padova, Esedra, 1992). He opposed extreme position in all fields, by styling himself 'Conciliator' of opposed tendencies. He often reconfirmed a rational concept of medicine and astronomy, which dispelled any demoniac and magic features, against the fanciful legend elaborated during the following centuries.

Dr. Wernher Von Braun

NASA Technical Reports Server (NTRS)

1999-01-01

Shown viewing the Apollo telescope mockup are, from left to right, Charles Donlan, deputy associate administrator for manned space flight; Dr. Wernher Von Braun, Marshall Space Flight Center director; William Horton, astrionics lab; Dr. Thomas Paine, NASA deputy administrator; Warner Kuers, director of the ME lab.

Developmentally arrested structures preceding cerebellar tumors in von Hippel–Lindau disease

PubMed Central

Shively, Sharon B; Falke, Eric A; Li, Jie; Tran, Maxine G B; Thompson, Eli R; Maxwell, Patrick H; Roessler, Erich; Oldfield, Edward H; Lonser, Russell R; Vortmeyer, Alexander O

2011-01-01

There is increasing evidence that suggests that knockout of tumor-suppressor gene function causes developmental arrest and protraction of cellular differentiation. In the peripheral nervous system of patients with the tumor-suppressor gene disorder, von Hippel–Lindau disease, we have demonstrated developmentally arrested structural elements composed of hemangioblast progenitor cells. Some developmentally arrested structural elements progress to a frank tumor, hemangioblastoma. However, in von Hippel–Lindau disease, hemangioblastomas are frequently observed in the cerebellum, suggesting an origin in the central nervous system. We performed a structural and topographic analysis of cerebellar tissues obtained from von Hippel–Lindau disease patients to identify and characterize developmentally arrested structural elements in the central nervous system. We examined the entire cerebella of five tumor-free von Hippel–Lindau disease patients and of three non-von Hippel–Lindau disease controls. In all, 9 cerebellar developmentally arrested structural elements were detected and topographically mapped in 385 blocks of von Hippel–Lindau disease cerebella. No developmentally arrested structural elements were seen in 214 blocks from control cerebella. Developmentally arrested structural elements are composed of poorly differentiated cells that express hypoxia-inducible factor (HIF)2α, but not HIF1α or brachyury, and preferentially involve the molecular layer of the dorsum cerebelli. For the first time, we identify and characterize developmentally arrested structural elements in the central nervous system of von Hippel–Lindau patients. We provide evidence that developmentally arrested structural elements in the cerebellum are composed of developmentally arrested hemangioblast progenitor cells in the molecular layer of the dorsum cerebelli. PMID:21499240

PT2385 for the Treatment of Von Hippel-Lindau Disease-Associated Clear Cell Renal Cell Carcinoma

ClinicalTrials.gov

2017-08-23

VHL Gene Mutation; VHL; VHL Syndrome; VHL Gene Inactivation; Von Hippel; Von Hippel-Lindau Disease; Von Hippel's Disease; Von Hippel-Lindau Syndrome, Modifiers of; Clear Cell Renal Cell Carcinoma; Clear Cell RCC; ccRCC

Wernher von Braun

NASA Image and Video Library

1963-03-28

Dr. von Braun, Director of the Marshall Space Flight Center (MSFC), and Dr. Debus, Director of the Launch Operations Center, at Complex 34 prior to the Launch of the SA-4 (the fourth flight of Saturn I), March 28, 1963. The mission conducted the second "Project Highwater" experiment, which the upper stage ejected 30,000 gallons of ballast water in the upper atmosphere for a physics experiment.

Wernher von Braun

NASA Image and Video Library

1968-10-01

Dr. von Braun, Director of the Marshall Space Flight Center (MSFC), greets Commander of Apollo 7 mission, Walter M. Schirra, Jr., during the mission briefing at Kennedy Space Center (KSC). The Apollo 7 mission, boosted by a Saturn IB launch vehicle on October 11, 1968, was the first flight of the Apollo spacecraft with crew. Other crew members were Astronaut Donn Eisele and Astronaut Walter Cunningham.

Weinberger-Powell and Transformation: Perceptions of American Power from the Fall of Saigon to the Fall of Baghdad

DTIC Science & Technology

2006-06-01

New York, NY: Pleiades Publishing, 2004), 1-16. 148 Fukuyama, Francis. The End of History and the Last Man (New York, NY: The Free Press, 1992...New York, NY: Pleiades Publishing, 2004. Clausewitz, Carl von. On War. trans. by Michael Howard and Peter Paret. Princeton, NJ: Princeton

Measurements in Quantum Mechanics and von NEUMANN's Model

NASA Astrophysics Data System (ADS)

Mello, Pier A.; Johansen, Lars M.

2010-12-01

Many textbooks on Quantum Mechanics are not very precise as to the meaning of making a measurement: as a consequence, they frequently make assertions which are not based on a dynamical description of the measurement process. A model proposed by von Neumann allows a dynamical description of measurement in Quantum Mechanics, including the measuring instrument in the formalism. In this article we apply von Neumann's model to illustrate the measurement of an observable by means of a measuring instrument and show how various results, which are sometimens postulated without a dynamical basis, actually emerge. We also investigate the more complex, intriguing and fundamental problem of two successive measurements in Quantum Mechanics, extending von Neumann's model to two measuring instruments. We present a description which allows obtaining, in a unified way, various results that have been given in the literature.

Test of Von Baer's law of the conservation of early development.

PubMed

Poe, Steven

2006-11-01

One of the oldest and most pervasive ideas in comparative embryology is the perceived evolutionary conservation of early ontogeny relative to late ontogeny. Karl Von Baer first noted the similarity of early ontogeny across taxa, and Ernst Haeckel and Charles Darwin gave evolutionary interpretation to this phenomenon. In spite of a resurgence of interest in comparative embryology and the development of mechanistic explanations for Von Baer's law, the pattern itself has been largely untested. Here, I use statistical phylogenetic approaches to show that Von Baer's law is an unnecessarily complex explanation of the patterns of ontogenetic timing in several clades of vertebrates. Von Baer's law suggests a positive correlation between ontogenetic time and amount of evolutionary change. I compare ranked position in ontogeny to frequency of evolutionary change in rank for developmental events and find that these measures are not correlated, thus failing to support Von Baer's model. An alternative model that postulates that small changes in ontogenetic rank are evolutionarily easier than large changes is tentatively supported.

Language and Reality. Peter Mittelstaedt's Contributions to the Philosophy of Physics

NASA Astrophysics Data System (ADS)

Falkenburg, Brigitte

2010-10-01

The article investigates the way in which Peter Mittelstaedt has been contributing to the philosophy of physics for half a century. It is shown that he pursues a path between rationalism and empiricism in the sense of Erhard Scheibe’s philosophy of the physicists. Starting from Kant’s a priori he gives a rational reconstruction of the conceptual revolutions of 20th century physics. The central topic of his philosophy of physics is the quest for semantic self-consistency, which for quantum mechanics is a hard nut to crack.

Dr. von Braun Tries Out the Neutral Buoyancy Simulator (NBS)

NASA Technical Reports Server (NTRS)

1967-01-01

Marshall Space Flight Center (MSFC) Director, Dr. von Braun, submerges after spending some time under water in the MSFC Neutral Buoyancy Simulator (NBS). Weighted to a neutrally buoyant condition, Dr. von Braun was able to perform tasks underwater which simulated weightless conditions found in space.

Valence bond and von Neumann entanglement entropy in Heisenberg ladders.

PubMed

Kallin, Ann B; González, Iván; Hastings, Matthew B; Melko, Roger G

2009-09-11

We present a direct comparison of the recently proposed valence bond entanglement entropy and the von Neumann entanglement entropy on spin-1/2 Heisenberg systems using quantum Monte Carlo and density-matrix renormalization group simulations. For one-dimensional chains we show that the valence bond entropy can be either less or greater than the von Neumann entropy; hence, it cannot provide a bound on the latter. On ladder geometries, simulations with up to seven legs are sufficient to indicate that the von Neumann entropy in two dimensions obeys an area law, even though the valence bond entanglement entropy has a multiplicative logarithmic correction.

Education, Philosophy and Politics: The Selected Works of Michael A. Peters. World Library of Educationalists

ERIC Educational Resources Information Center

Peters, Michael A.

2012-01-01

In the World Library of Educationalists series, international experts themselves compile career-long collections of what they judge to be their finest pieces--extracts from books, key articles, salient research findings, major theoretical and/practical contributions--so the world can read them in a single manageable volume. Michael A. Peters has…

Wildlife and Wildlife Habitat Loss Assessment at Green Peter-Foster Project; Middle Fork Santiam River, Oregon, 1985 Final Report.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Noyes, J.H.

1986-02-01

A habitat based assessment was conducted of the US Army Corps of Engineers' Green Peter-Foster Dam and Reservoir Project on the Middle Fork Santiam River, Oregon, to determine losses or gains resulting from the development and operation of the hydroelectric related components of the project. Preconstruction, postconstruction, and recent vegetation cover types at the project site were mapped based on aerial photographs from 1955, 1972, and 1979, respectively. Vegetation cover types were identified within the affected area and acreages of each type at each period were determined. Eleven wildlife target species were selected to represent a cross-section of species groupsmore » affected by the project. An interagency team evaluated the suitability of the habitat to support the target species at each time period. An evaluation procedure which accounted for both the quantity and quality of habitat was used to aid in assessing impacts resulting from the project. The Green Peter-Foster Project extensively altered or affected 7873 acres of land and river in the Santiam River drainage. Impacts to wildlife centered around the loss of 1429 acres of grass-forb vegetation, 768 acres of shrubland, and 717 acres of open conifer forest cover types. Impacts resulting from the Green Peter-Foster Project included the loss of critical winter range for black-tailed deer and Roosevelt elk, and the loss of year-round habitat for deer, upland game birds, river otter, beaver, pileated woodpecker, and many other wildlife species. Bald eagle and osprey were benefited by an increase in foraging habitat. The potential of the affected area to support wildlife was greatly altered as a result of the Green Peter-Foster Project. Losses or gains in the potential of the habitat to support wildlife will exist over the life of the project.« less

Wernher von Braun with German Officers and Others

NASA Technical Reports Server (NTRS)

1942-01-01

General Erich Fellgiebel, head of the German Army Information Service during World War II, congratulates members of the von Braun rocket team from Peenemunde for their October 3, 1942 A4 flight. Pictured front center is General Erich Fellgiebel. Shaking hands are General Walter Dornberger (left) and General Janssen, commanding officer of Peenemuende with Rudolph Hermarn to their right. Picture left to right in the back row are Wernher von Braun, Captain Stoelzel, Luftwaffe, and Dr. Gerhard Reisig.

An Interview with Peter McLaren: Comments on the State of the World-2005

ERIC Educational Resources Information Center

Shaughnessy, Michael F.

2006-01-01

Some of the wide range of thoughtful topics discussed in this interview with Peter McLaren include: (1) The top five points that McLaren tried to make in his book, "Capitalists and Conquerors: A Critical Pedagogy Against Empire"; (2) McLaren's thoughts on what he thinks the George Bush legend will be; (3) What led McLaren to ask,…

1988 Horton Medal presented to Peter S. Eagleson

NASA Astrophysics Data System (ADS)

Rodriguez-Iturbe, Ignacio; Eagleson, Peter S.

It is indeed a great honor for me, and also a great pleasure, to present to you the 1988 recipient of the Robert E. Horton Medal, Peter S. Eagleson. Shortly after it became public that Pete was the winner of this year's medal, I commented to my wife that, although I had never given a citation for an AGU medalist, this was one I would really love to give. The reason is simple: there is no one in the world who better represents the standards of excellence that a hydrologist hopes to achieve and that hydrologists hope our discipline will attain than Peter Eagleson.Pete did not start his research career in hydrology. In fact, his Ph.D. thesis in 1956 and his research up to 1965 were mainly in the field of sediment sorting and transport by waves on beaches. During this period he also investigated problems related to flow-induced vibrations of plates. His research in these areas was extremely successful, producing three chapters in books and about 20 journal papers in addition to many technical reports and journal discussions. Indeed, Pete had made his mark in wave theory and sediment transport, but it was good fortune for our field that starting about 1964 his interest in hydrology overcame all his past experience and assured a reputation in the waves and sediment field, and thus he embarked on a new adventure—bringing into hydrology the scientific rigor that existed in more academically established disciplines. With his strong fluid mechanics background—he still teaches that subject to undergraduates at MIT—Pete was ideally suited to lead the field toward new problems and also toward new approaches to old problems . . . and this he did indeed! Just in 1967 he and his students published six papers, most of them in Water Resources Research, which had a strong, an almost immediate impact on the field of hydrology. Here was somebody who was tackling the modeling of overland flow with the scientific standards of fluid mechanics. At the same time, finally somebody had

Between Fiction and Reality: Maps and Cartographic Logic in the Works of Peter Sís

ERIC Educational Resources Information Center

Cantavella, Anna Juan

2017-01-01

This article examines the use of maps in the works of Czech author-illustrator Peter Sís in order to consider the role that cartography plays in the construction of four of his biographical picturebooks: Follow the Dream: "The Story of Christopher Columbus" (2003/1991), "Starry Messenger: Galileo Galilei" (1996), "The Tree…

JPRS Report East Europe.

DTIC Science & Technology

1990-06-01

the brief signed, among others, by Jakob Moneta, of Stalinism and the refusal of the SED leadership to face Hermann Weber, Peter von Oertzen, Lev...Merker, Kurt Mueller, Fritz Sperling , the investigation of the purges in the SED, about which Paul Szillat, and Stanislaus Trabalski). In 1946, 14

Evolution of Capsaicinoids in Peter Pepper (Capsicum annuum var. annuum) During Fruit Ripening.

PubMed

Barbero, Gerardo F; de Aguiar, Ana C; Carrera, Ceferino; Olachea, Ángel; Ferreiro-González, Marta; Martínez, Julian; Palma, Miguel; Barroso, Carmelo G

2016-08-01

The evolution of individual and total contents of capsaicinoids present in Peter peppers (Capsicum annuum var. annuum) at different ripening stages has been studied. Plants were grown in a glasshouse and the new peppers were marked in a temporal space of ten days. The extraction of capsaicinoids was performed by ultrasound-assisted extraction with MeOH. The capsaicinoids nordihydrocapsaicin (n-DHC), capsaicin, dihydrocapsaicin, homocapsaicin, and homodihydrocapsaicin were analyzed by ultraperformance liquid chromatography (UHPLC)-fluorescence and identified by UHPLC-Q-ToF-MS. The results indicate that the total capsaicinoids increase in a linear manner from the first point of harvest at ten days (0.283 mg/g FW) up to 90 days, at which point they reach a concentration of 1.301 mg/g FW. The evolution as a percentage of the individual capsaicinoids showed the initial predominance of capsaicin, dihydrocapsaicin, and n-DHC. Dihydrocapsaicin was the major capsaicinoid up to day 50 of maturation. After 50 days, capsaicin became the major capsaicinoid as the concentration of dihydrocapsaicin fell slightly. The time of harvest of Peter pepper based on the total capsaicinoids content should be performed as late as possible. In any case, harvesting should be performed before overripening of the fruit is observed. © 2016 Wiley-VHCA AG, Zürich.

Die Kosmogonie Anton von Zachs.

NASA Astrophysics Data System (ADS)

Brosche, P.

In his "Cosmogenische Betrachtungen" (1804), Anton von Zach rediscovered - probably independently - some aspects of the theories of Kant and Laplace. More originally, he envisaged also the consequences of an era of heavy impacts in the early history of the Earth.

Peter Andreas Hansen and the astronomical community - a first investigation of the Hansen papers. (German Title: Peter Andreas Hansen und die astronomische Gemeinschaft - eine erste Auswertung des Hansen-Nachlasses. )

NASA Astrophysics Data System (ADS)

Schwarz, Oliver; Strumpf, Manfred

The literary assets of Peter Andreas Hansen are deposited in the Staatsarchiv Hamburg, the Forschungs- und Landesbibliothek Gotha and the Thüringer Staatsarchiv Gotha. They were never systematically investigated. We present here some results of a first evaluation. It was possible to reconstruct the historical events with regard to the maintenance of the Astronomische Nachrichten and the Altona observatory in 1854. Hansen was a successful teacher for many young astronomers. His way of stimulating the evolution of astronomy followed Zach's tradition.

Dr. von Braun Tries Out the Neutral Buoyancy Simulator (NBS)

NASA Technical Reports Server (NTRS)

1967-01-01

Marshall Space Flight Center (MSFC) Director, Dr. von Braun, is shown leaving the suiting-up van wearing a pressure suit prepared for a tryout in the MSFC Neutral Buoyancy Simulator (NBS). Weighted to a neutrally buoyant condition, Dr. von Braun was able to perform tasks underwater which simulated weightless conditions found in space.

76 FR 13271 - Gulf & Ohio Railways, Inc., H. Peter Claussen and Linda C. Claussen-Continuance in Control...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-10

... DEPARTMENT OF TRANSPORTATION Surface Transportation Board [Docket No. FD 35414] Gulf & Ohio Railways, Inc., H. Peter Claussen and Linda C. Claussen--Continuance in Control Exemption--Lancaster & Chester Railroad, LLC AGENCY: Surface Transportation Board, DOT. ACTION: Correction to notice of exemption...

Dr. Wernher Von Braun

NASA Technical Reports Server (NTRS)

1999-01-01

Marshall Space Flight Center director Wernher Von Braun and his family were honored with a series of events prior to his relocation to Washington, D.C. where he was assigned duties at NASA headquarters as deputy associate administrator for planning. Here he is shown with General Richard Drury and Hazel Toftoy, widow of General H.N. Toftoy.

Evaluation of the Utility of von Willebrand Factor Propeptide in the Differential Diagnosis of von Willebrand Disease and Acquired von Willebrand Syndrome.

PubMed

Stufano, Francesca; Boscarino, Marco; Bucciarelli, Paolo; Baronciani, Luciano; Maino, Alberto; Cozzi, Giovanna; Peyvandi, Flora

2018-06-18

An increased von Willebrand factor propeptide (VWFpp) to VWF antigen (VWF:Ag) ratio (VWFpp/VWF:Ag) indicates an enhanced clearance of VWF. This finding has been described in von Willebrand disease (VWD) and in acquired von Willebrand syndrome (AVWS). A distinction between these two diseases, one congenital and the other acquired, is primarily based on family and personal history of bleeding. However, if this information is scanty, the diagnosis might be challenging due to the lack of an effective diagnostic biomarker. In this cross-sectional study, we assessed the ability of VWFpp/VWF:Ag for the differential diagnosis between VWD and AVWS. VWFpp/VWF:Ag was measured in a group of 153 patients (125 with VWD and 28 with AVWS). Most patients with AVWS and VWD showed an increased VWFpp/VWF:Ag, although to variable degrees. A marked increase of VWFpp/VWF:Ag was mainly associated with the diagnosis of AVWS and VWD type 1 Vicenza. A receiver operating characteristic curve was used to identify the optimal cutoff of VWFpp/VWF:Ag for discrimination of patients with a modestly increased (most VWD cases) versus those with a markedly increased clearance (AVWS and VWD type 1 Vicenza), and this cutoff was identified at the value of 3.9 (sensitivity: 0.70, specificity: 0.97). The ROC curve sorting from a logistic model containing VWFpp/VWF:Ag, age, and sex had an area under the curve (AUC) of 0.88 (95% confidence interval: 0.80-0.95). A subsequent molecular evaluation discriminated VWD type 1 Vicenza from AVWS. In conclusion, VWFpp/VWF:Ag appears helpful to discriminate patients with a markedly increase VWF clearance (AVWS or VWD type 1 Vicenza) from those with a modestly increased clearance (most VWD patients). Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Zuverlässigkeit digitaler Schaltungen unter Einfluss von intrinsischem Rauschen

NASA Astrophysics Data System (ADS)

Kleeberger, V. B.; Schlichtmann, U.

2011-08-01

Die kontinuierlich fortschreitende Miniaturisierung in integrierten Schaltungen führt zu einem Anstieg des intrinsischen Rauschens. Um den Einfluss von intrinsischem Rauschen auf die Zuverlässigkeit zukünftiger digitaler Schaltungen analysieren zu können, werden Methoden benötigt, die auf CAD-Verfahren wie Analogsimulation statt auf abschätzenden Berechnungen beruhen. Dieser Beitrag stellt eine neue Methode vor, die den Einfluss von intrinsischem Rauschen in digitalen Schaltungen für eine gegebene Prozesstechnologie analysieren kann. Die Amplituden von thermischen, 1/f und Schrotrauschen werden mit Hilfe eines SPICE Simulators bestimmt. Anschließend wird der Einfluss des Rauschens auf die Schaltungszuverlässigkeit durch Simulation analysiert. Zusätzlich zur Analyse werden Möglichkeiten aufgezeigt, wie die durch Rauschen hervorgerufenen Effekte im Schaltungsentwurf mit berücksichtigt werden können. Im Gegensatz zum Stand der Technik kann die vorgestellte Methode auf beliebige Logikimplementierungen und Prozesstechnologien angewendet werden. Zusätzlich wird gezeigt, dass bisherige Ansätze den Einfluss von Rauschen bis um das Vierfache überschätzen.

Local and Global in the Formation of a Learning Theorist: Peter Jarvis and Adult Education

ERIC Educational Resources Information Center

Holford, John

2017-01-01

Peter Jarvis is a towering figure in the study of adult and lifelong education and a leading and original theorist of learning. This paper sets out his intellectual and professional biography, maps the main contours of his work and introduces fourteen papers by leading scholars devoted to his work. Five broad phases in Jarvis' life are identified:…

Toward the Defence of Australia

DTIC Science & Technology

1990-04-01

Colonel R. Crawshaw , "Low-Level Conflict - A Closer Scrutiny," Defence Force Journal, No. 69, March/April 1988, pp. 6-9. 6. Air Commodore N. F...Clauswitz, Carl Von, QOn-War, edited and translated by Michael Howard and Peter Paret. PrirLcetun : Universi ty Press, 1984. Crawshaw , Lieutenant Colonel P

mRNAs for PRPs, statherin, and histatins in von Ebner's gland tissues.

PubMed

Azen, E A; Hellekant, G; Sabatini, L M; Warner, T F

1990-11-01

A search was made for expression of genes for proline-rich proteins (PRPs) and other salivary-type proteins, including statherin and histatins, in taste-bud tissues of mice and primates because of previous genetic findings in mice (Azen et al., 1986) that Prp and taste genes for certain bitter substances are either the same or closely linked. Taste-bud tissues and other tissues were tested for specific mRNAs with labeled DNA probes by Northern blotting and in situ hybridization. It was found that PRP mRNAs were present in von Ebner's glands of mice and macaques, and that there was a much greater degree of PRP mRNA induction in mouse parotid (16-fold) than in von Ebner's gland (two-fold) after in vivo isoproterenol stimulation. This difference may be due, in part, to differences in autonomic nerve innervation. Statherin and histatin mRNAs were found in macaque taste-bud tissues containing von Ebner's gland, and statherin protein was found in human von Ebner's gland by immunohistochemistry. The finding of PRP gene expression in von Ebner's gland, whose secretions have been suggested to play a role in taste stimulation, adds further support to a possible function of PRPs in bitter tasting. The possible functions of statherin and histatins in von Ebner's gland secretions may be related to statherin's regulation of salivary calcium and histatins' antibacterial and antifungal properties.

Victor or Villain? Wernher von Braun and the Space Race

ERIC Educational Resources Information Center

O'Brien, Jason L.; Sears, Christine E.

2011-01-01

Set during the Cold War and space race, this historical role-play focuses on Wernher von Braun's involvement in and culpability for the use of slave laborers to produce V-2 rockets for Nazi Germany. Students will grapple with two central questions. Should von Braun have been allowed to emigrate to the United States given his affiliation with the…

Wernher von Braun

NASA Image and Video Library

1966-06-21

Dr. Joseph Randall, a laser expert at Marshall Space Flight Center (MSFC), explains one of the projects he is working on to a group composed of Federal Republic of Germany and MSFC officials. From left are: Dr. Randall; Minister for Scientific Research of Federal Republic of Germany, Dr. Gerhard Stolenberg; Director of MSFC Astrionics Lab, Dr. Walter Haeusserman; Head of Space Research Federal Republic of Germany, Max Mayer; MSFC Director Dr. von Braun; MSFC Deputy Director Dr. Elberhard Rees.

Wernher von Braun

NASA Image and Video Library

1968-10-01

Dr. von Braun inside the KC-135 in flight. The KC-135 provide NASA's Reduced-Gravity Program the unique weightlessness or zero-g environment of space flight for testing and training of human and hardware reactions. The recent version, KC-135A, is a specially modified turbojet transport which flies parabolic arcs to produce weightlessness periods of 20 to 25 seconds and its cargo bay test area is approximately 60 feet long, 10 feet wide, and 7 feet high.

Solution of Peter Winkler's Pizza Problem

NASA Astrophysics Data System (ADS)

Cibulka, Josef; Kynčl, Jan; Mészáros, Viola; Stolař, Rudolf; Valtr, Pavel

Bob cuts a pizza into slices of not necessarily equal size and shares it with Alice by alternately taking turns. One slice is taken in each turn. The first turn is Alice's. She may choose any of the slices. In all other turns only those slices can be chosen that have a neighbor slice already eaten. We prove a conjecture of Peter Winkler by showing that Alice has a strategy for obtaining 4/9 of the pizza. This is best possible, that is, there is a cutting and a strategy for Bob to get 5/9 of the pizza. We also give a characterization of Alice's best possible gain depending on the number of slices. For a given cutting of the pizza, we describe a linear time algorithm that computes Alice's strategy gaining at least 4/9 of the pizza and another algorithm that computes the optimal strategy for both players in any possible position of the game in quadratic time. We distinguish two types of turns, shifts and jumps. We prove that Alice can gain 4/9, 7/16 and 1/3 of the pizza if she is allowed to make at most two jumps, at most one jump and no jump, respectively, and the three constants are the best possible.

Physik gestern und heute Von der Metallstange zum Hochenergielaser

NASA Astrophysics Data System (ADS)

Heering, Peter

2002-05-01

Im Mai 1752 wurde in Marly bei Paris auf Anregung des amerikanischen Forschers und Politikers Benjamin Franklin erstmals die elektrische Natur des Blitzes nachgewiesen. Damals beschrieb Franklin auch eine technische Vorrichtung, die als Schutz von Gebäuden vor Blitzschlägen dienen sollte: den Blitzableiter. Diese aus heutiger Sicht scheinbar triviale Vorrichtung wurde aber keineswegs unmittelbar akzeptiert. Und bis heute ist die Forschung zum Schutz von Einrichtungen vor Blitzschlägen nicht abgeschlossen.

von Baer's law for the ages: lost and found principles of developmental evolution.

PubMed

Abzhanov, Arhat

2013-12-01

In 1828, Karl Ernst von Baer formulated a series of empirically defined rules, which became widely known as the 'Law of Development' or 'von Baer's law of embryology'. This was one the most significant attempts to define the principles that connected morphological complexity and embryonic development. Understanding this relation is central to both evolutionary biology and developmental genetics. Von Baer's ideas have been both a source of inspiration to generations of biologists and a target of continuous criticism over many years. With advances in multiple fields, including paleontology, cladistics, phylogenetics, genomics, and cell and developmental biology, it is now possible to examine carefully the significance of von Baer's law and its predictions. In this review, I argue that, 185 years after von Baer's law was first formulated, its main concepts after proper refurbishing remain surprisingly relevant in revealing the fundamentals of the evolution-development connection, and suggest that their explanation should become the focus of renewed research. Copyright © 2013 Elsevier Ltd. All rights reserved.

Shallowing-upward cyclic patterns within larger-scale transgressive-regressive (T-R) sedimentary sequences, St. Peter through Decorah Formations, Ordovician, Iowa area

DOE Office of Scientific and Technical Information (OSTI.GOV)

Witzke, B.J.

1993-03-01

Four large-scale (2--8 Ma) T-R sedimentary sequences of M. Ord. age (late Chaz.-Sherm.) were delimited by Witzke Kolata (1980) in the Iowa area, each bounded by local to regional unconformity/disconformity surfaces. These encompass both siliciclastic and carbonate intervals, in ascending order: (1) St. Peter-Glenwood fms., (2) Platteville Fm., (3) Decorah Fm., (4) Dunleith/upper Decorah fms. Finer-scale resolution of depth-related depositional features has led to regional recognition of smaller-scale shallowing-upward cyclicity contained within each large-scale sequence. Such smaller-scale cyclicity encompasses stratigraphic intervals of 1--10 m thickness, with estimated durations of 0.5--1.5 Ma. The St. Peter Sandst. has long been regarded asmore » a classic transgressive sheet sand. However, four discrete shallowing-upward packages characterize the St. Peter-Glenwood interval regionally (IA, MN, NB, KS), including western facies displaying coarsening-upward sandstone packages with condensed conodont-rich brown shale and phosphatic sediments in their lower part (local oolitic ironstone), commonly above pyritic hardgrounds. Regional continuity of small-scale cyclic patterns in M. Ord. strata of the Iowa area may suggest eustatic controls; this can be tested through inter-regional comparisons.« less

Dr. von Braun Tries Out the Neutral Buoyancy Simulator (NBS)

NASA Technical Reports Server (NTRS)

1967-01-01

Astronaut L. Gordon Cooper checks the neck ring of a space suit worn by Marshall Space Flight Center (MSFC) Director, Dr. von Braun before he submerges into the water of the MSFC Neutral Buoyancy Simulator (NBS). Wearing a pressurized suit and weighted to a neutrally buoyant condition, Dr. von Braun was able to perform tasks underwater which simulated weightless conditions found in space.

A Pedagogy of Dealienation: A Case Study in the Application of Peter Berger's "The Sacred Canopy"

ERIC Educational Resources Information Center

Chance, J. Bradley

2004-01-01

This paper explores the use of Peter Berger's theory of religion and its features of alienation and dealienation to lead students to the critical awareness of the role that human beings play in the construction of social worlds, including most especially our religious worlds. After summarizing Berger's theory of the alienating and potentially…

A Genealogical Analysis of Peter Arnold's Conceptual Account of Meaning in Movement, Sport and Physical Education

ERIC Educational Resources Information Center

Stolz, Steven A.; Thorburn, Malcolm

2017-01-01

We write as critical theorists who share an interest in how conceptions of physical education are taken forward in policy and practice. In this respect, we are particularly intrigued by Peter Arnold's conceptual account of meaning in movement, sport and physical education, and the subsequent ways in which his ideas have informed national…

Wernher von Braun

NASA Image and Video Library

1960-01-01

In this photo, Director of the US Army Ballistic Missile Agency (ABMA) Development Operations Division, Dr. Wernher von Braun, is standing before a display of Army missiles celebrating ABMA's Fourth Open House. The missiles in the background include (left to right) a satellite on a Juno II shroud with a Nike Ajax pointing left in front of a Jupiter missile. The Lacrosse is in front of the Juno II. The Nike Hercules points skyward in front of the Juno II and the Redstone.

Molecular quantum control landscapes in von Neumann time-frequency phase space

NASA Astrophysics Data System (ADS)

Ruetzel, Stefan; Stolzenberger, Christoph; Fechner, Susanne; Dimler, Frank; Brixner, Tobias; Tannor, David J.

2010-10-01

Recently we introduced the von Neumann representation as a joint time-frequency description for femtosecond laser pulses and suggested its use as a basis for pulse shaping experiments. Here we use the von Neumann basis to represent multidimensional molecular control landscapes, providing insight into the molecular dynamics. We present three kinds of time-frequency phase space scanning procedures based on the von Neumann formalism: variation of intensity, time-frequency phase space position, and/or the relative phase of single subpulses. The shaped pulses produced are characterized via Fourier-transform spectral interferometry. Quantum control is demonstrated on the laser dye IR140 elucidating a time-frequency pump-dump mechanism.

Molecular quantum control landscapes in von Neumann time-frequency phase space.

PubMed

Ruetzel, Stefan; Stolzenberger, Christoph; Fechner, Susanne; Dimler, Frank; Brixner, Tobias; Tannor, David J

2010-10-28

Recently we introduced the von Neumann representation as a joint time-frequency description for femtosecond laser pulses and suggested its use as a basis for pulse shaping experiments. Here we use the von Neumann basis to represent multidimensional molecular control landscapes, providing insight into the molecular dynamics. We present three kinds of time-frequency phase space scanning procedures based on the von Neumann formalism: variation of intensity, time-frequency phase space position, and/or the relative phase of single subpulses. The shaped pulses produced are characterized via Fourier-transform spectral interferometry. Quantum control is demonstrated on the laser dye IR140 elucidating a time-frequency pump-dump mechanism.

Peter Andreas Hansen und die astronomische Gemeinschaft - eine erste Auswertung des Hansen-Nachlasses.

NASA Astrophysics Data System (ADS)

Schwarz, O.; Strumpf, M.

The literary assets of Peter Andreas Hansen are deposited in the Staatsarchiv Hamburg, the Forschungs- und Landesbibliothek Gotha and the Thüringer Staatsarchiv Gotha. They were never systematically investigated. The authors present here some results of a first evaluation. It was possible to reconstruct the historical events with regard to the maintenance of the Astronomische Nachrichten and the Altona observatory in 1854. Hansen was a successful teacher for many young astronomers. His way of stimulating the evolution of astronomy followed Zach's tradition.

Paradoxes of a Long Life Learning: An Exploration of Peter Jarvis's Contribution to Experiential Learning Theory

ERIC Educational Resources Information Center

Dyke, Martin

2017-01-01

The paper explores the work of Peter Jarvis related to learning with particular reference to his definitions of learning and his models of the learning process. This exploration will consider different approaches to experiential learning and demonstrate the contribution Jarvis has made, noting how his writing on the subject has changed over time.…

[Precocious puberty and von Recklinghausen's disease].

PubMed

Barg, Ewa; Wikiera, Beata; Basiak, Aleksander; Głab, Ewa

2006-01-01

Von Recklinghausen's disease belongs to a group of neurocutaneous syndromes and is characterised by skin, nerve and bone abnormalities. We present a case of von Recklinghausen's disease and precocious puberty in 7-year-old boy. At the age of three café au lait spots on the skin and an incranial tumour situated near the optic chiasm--qualified as inoperable--were discovered. At the age of 7 first signs of precocious puberty appeared (pubic hair P3 and enlargement of the testes (15 ml) and penis). Laboratory measurements included: LH 7.5 mIU/ml, FSH 1.1 mIU/ml, testosterone 183 ng/ml, assessment of bone age: 9 years. The response to LHRH stimulation was characteristic for true precocious puberty (LH 15.9 mIU/ml and FSH 1.5 mIU/ml after 30 minutes). The MRI of the brain showed a tumour of the suprasellar region with compression of pituitary stalk. True precocious puberty was diagnosed. Treatment with Diphereline was introduced. At present the boy is 9 years old and has been treated with Diphereline for 16 months. The volume of the testicles has decreased to 7 ml and loss of pubic hair was noted. The MRI does not show any progression in tumour growth. The authors would like to underline the need of close observation of children with von Reclinghausen disease with regard to possibility of uncovering true precocious puberty which is critical for rapid diagnosis and introduction of correct treatment.

Superfund Record of Decision (EPA Region 5): Reilly Tar and Chemical Corporation Site, St. Peter Aquifer, St. Louis Park, MN. (Third remedial action), September 1990

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1990-09-28

The 80-acre Reilly Tar and Chemical (St. Louis Park) site is a former coal tar distillation and wood preserving plant in St. Louis Park, Minnesota. The site overlies a complex system of aquifers, including the St. Peter aquifer that provide drinking water to area residences. The St. Peter Aquifer contains one municipal well, which is used during periods of peak demand, however, the majority of the drinking water in St. Louis Park is obtained from deeper aquifers. From 1917 to 1972, wastewater containing creosote and coal tar was discharged to onsite surface water, and as a result, small wastewater spillsmore » occurred into onsite soil. The ROD addresses Operable Unit 4 (OU4), remediation of the St. Peter aquifer. A subsequent ROD will address any remaining site problems as OU3. The primary contaminants of concern affecting the ground water are organics including PAHs and phenols.« less

The smooth entropy formalism for von Neumann algebras

NASA Astrophysics Data System (ADS)

Berta, Mario; Furrer, Fabian; Scholz, Volkher B.

2016-01-01

We discuss information-theoretic concepts on infinite-dimensional quantum systems. In particular, we lift the smooth entropy formalism as introduced by Renner and collaborators for finite-dimensional systems to von Neumann algebras. For the smooth conditional min- and max-entropy, we recover similar characterizing properties and information-theoretic operational interpretations as in the finite-dimensional case. We generalize the entropic uncertainty relation with quantum side information of Tomamichel and Renner and discuss applications to quantum cryptography. In particular, we prove the possibility to perform privacy amplification and classical data compression with quantum side information modeled by a von Neumann algebra.

The smooth entropy formalism for von Neumann algebras

DOE Office of Scientific and Technical Information (OSTI.GOV)

Berta, Mario, E-mail: berta@caltech.edu; Furrer, Fabian, E-mail: furrer@eve.phys.s.u-tokyo.ac.jp; Scholz, Volkher B., E-mail: scholz@phys.ethz.ch

2016-01-15

We discuss information-theoretic concepts on infinite-dimensional quantum systems. In particular, we lift the smooth entropy formalism as introduced by Renner and collaborators for finite-dimensional systems to von Neumann algebras. For the smooth conditional min- and max-entropy, we recover similar characterizing properties and information-theoretic operational interpretations as in the finite-dimensional case. We generalize the entropic uncertainty relation with quantum side information of Tomamichel and Renner and discuss applications to quantum cryptography. In particular, we prove the possibility to perform privacy amplification and classical data compression with quantum side information modeled by a von Neumann algebra.

Von Bertalanffy's dynamics under a polynomial correction: Allee effect and big bang bifurcation

NASA Astrophysics Data System (ADS)

Leonel Rocha, J.; Taha, A. K.; Fournier-Prunaret, D.

2016-02-01

In this work we consider new one-dimensional populational discrete dynamical systems in which the growth of the population is described by a family of von Bertalanffy's functions, as a dynamical approach to von Bertalanffy's growth equation. The purpose of introducing Allee effect in those models is satisfied under a correction factor of polynomial type. We study classes of von Bertalanffy's functions with different types of Allee effect: strong and weak Allee's functions. Dependent on the variation of four parameters, von Bertalanffy's functions also includes another class of important functions: functions with no Allee effect. The complex bifurcation structures of these von Bertalanffy's functions is investigated in detail. We verified that this family of functions has particular bifurcation structures: the big bang bifurcation of the so-called “box-within-a-box” type. The big bang bifurcation is associated to the asymptotic weight or carrying capacity. This work is a contribution to the study of the big bang bifurcation analysis for continuous maps and their relationship with explosion birth and extinction phenomena.

Utilization of the St. Peter Sandstone in the Illinois Basin for CO2 Sequestration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Will, Robert; Smith, Valerie; Leetaru, Hannes

2014-09-30

This project is part of a larger project co-funded by the United States Department of Energy (US DOE) under cooperative agreement DE-FE0002068 from 12/08/2009 through 9/31/2014. The study is to evaluate the potential of formations within the Cambro-Ordovician strata above the Mt. Simon Sandstone as potential targets for carbon dioxide (CO2) sequestration in the Illinois and Michigan Basins. This report evaluates the potential injectivity of the Ordovician St. Peter Sandstone. The evaluation of this formation was accomplished using wireline data, core data, pressure data, and seismic data acquired through funding in this project as well as existing data from twomore » additional, separately funded projects: the US DOE funded Illinois Basin – Decatur Project (IBDP) being conducted by the Midwest Geological Sequestration Consortium (MGSC) in Macon County, Illinois, and the Illinois Industrial Carbon Capture and Sequestration (ICCS) Project funded through the American Recovery and Reinvestment Act (ARRA), which received a phase two award from DOE. This study addresses the question of whether or not the St. Peter Sandstone may serve as a suitable target for CO2 sequestration at locations within the Illinois Basin where it lies at greater depths (below the underground source of drinking water (USDW)) than at the IBDP site. The work performed included numerous improvements to the existing St. Peter reservoir model created in 2010. Model size and spatial resolution were increased resulting in a 3 fold increase in the number of model cells. Seismic data was utilized to inform spatial porosity distribution and an extensive core database was used to develop porosity-permeability relationships. The analysis involved a Base Model representative of the St. Peter at “in-situ” conditions, followed by the creation of two hypothetical models at in-situ + 1,000 feet (ft.) (300 m) and in-situ + 2,000 ft. (600 m) depths through systematic depthdependent adjustment of the Base

Hazardous Waste Cleanup: Von Roll Isola USA Incorporated in Schenectady, New York

EPA Pesticide Factsheets

The Riverview facility is a 52-acre manufacturing facility located on Von Roll Drive in Schenectady, New York. The facility is owned and operated by Von Roll Isola USA, Inc., and produces solid and liquid insulating materials and tapes for the electrical

The significance of stylolitization and intergranular pressure solution in the formation of pressure compartment seals in the St. Peter Sandstone, Ordovician, Michigan basin

DOE Office of Scientific and Technical Information (OSTI.GOV)

Drzewiecki, P.A.; Simo, T.; Moline, G.

1991-03-01

The Middle to Late Ordovician St. Peter Sandstone of the Michigan basin is a fine- to medium-grained quartz sandstone. Extensive stylolitization and intergranular pressure solution have been major factors in reducing the porosity of certain horizons within the St. Peter, resulting in pressure compartmentation of the reservoir. Pressure versus depth data for various Michigan basin wells indicate that the basin contains compartments that are overpressured by as much as 500 psi. Horizons bounding these compartments are often affected by intense stylolitization (or intergranular pressure solution) and quartz cementation and have been correlated with zones of low porosity and permeability ({phi}more » = 0-3%, k = <50 {mu}d). These tight zones can be correlated within single gas fields, and some may extend across the Michigan basin. The St. Peter Sandstone has been buried to depths of about 3,500 m in the central part of the basin and 1,500 m at the margins. Intensely stylolitized zones are found at all depths throughout the basin and do not appear to change in abundance or style with depths. Factors that influence the formation, morphology, and abundance of stylolites in the St. Peter include (1) clay intraclasts, (2) intergranular clay, and (3) fine-grained, feldspar-rich sand. Stylolites also occur at contacts between quartz-cemented and carbonate-cemented zones and within well-cemented sands. Intergranular pressure solution and stylolites may be responsible for the formation of a compartment seal. Understanding their genesis can allow prediction of variations in porosity in Michigan basin well cores.« less

Die nuklearen Anlagen von Hanford (1943-1987) Eine Fallstudie über die Schnittstellen von Physik, Biologie und die US-amerikanische Gesellschaft zur Zeit des Kalten Krieges

NASA Astrophysics Data System (ADS)

Macuglia, Daniele

Die Geschichte des Kalten Krieges eröffnet viele Möglichkeiten, sich näher mit den Schnittstellen von Physik und Biologie während des 20. Jahrhunderts zu befassen. Nicht nur das Unglück in Tschernobyl aus dem Jahr 1986, auch das Beispiel der nuklearen Anlagen in Hanford in den Vereinigten Staaten zeigt die biologischen Folgen von nuklearer Physik.

Von Neumann entropy in a Rashba-Dresselhaus nanodot; dynamical electronic spin-orbit entanglement

NASA Astrophysics Data System (ADS)

Safaiee, Rosa; Golshan, Mohammad Mehdi

2017-06-01

The main purpose of the present article is to report the characteristics of von Neumann entropy, thereby, the electronic hybrid entanglement, in the heterojunction of two semiconductors, with due attention to the Rashba and Dresselhaus spin-orbit interactions. To this end, we cast the von Neumann entropy in terms of spin polarization and compute its time evolution; with a vast span of applications. It is assumed that gate potentials are applied to the heterojunction, providing a two dimensional parabolic confining potential (forming an isotropic nanodot at the junction), as well as means of controlling the spin-orbit couplings. The spin degeneracy is also removed, even at electronic zero momentum, by the presence of an external magnetic field which, in turn, leads to the appearance of Landau states. We then proceed by computing the time evolution of the corresponding von Neumann entropy from a separable (spin-polarized) initial state. The von Neumann entropy, as we show, indicates that electronic hybrid entanglement does occur between spin and two-dimensional Landau levels. Our results also show that von Neumann entropy, as well as the degree of spin-orbit entanglement, periodically collapses and revives. The characteristics of such behavior; period, amplitude, etc., are shown to be determined from the controllable external agents. Moreover, it is demonstrated that the phenomenon of collapse-revivals' in the behavior of von Neumann entropy, equivalently, electronic hybrid entanglement, is accompanied by plateaus (of great importance in quantum computation schemes) whose durations are, again, controlled by the external elements. Along these lines, we also make a comparison between effects of the two spin-orbit couplings on the entanglement (von Neumann entropy) characteristics. The finer details of the electronic hybrid entanglement, which may be easily verified through spin polarization measurements, are also accreted and discussed. The novel results of the present

The molecular genetics of von Willebrand disease.

PubMed

Berber, Ergül

2012-12-01

Quantitative and/or qualitative deficiency of von Willebrand factor (vWF) is associated with the most common inherited bleeding disease von Willebrand disease (vWD). vWD is a complex disease with clinical and genetic heterogeneity. Incomplete penetrance and variable expression due to genetic and environmental factors contribute to its complexity. vWD also has a complex molecular pathogenesis. Some vWF gene mutations are associated with the affected vWF biosynthesis and multimerization, whereas others are associated with increased clearance and functional impairment. Moreover, in addition to a particular mutation, type O blood may result in the more severe phenotype. The present review aimed to provide a summary of the current literature on the molecular genetics of vWD. None declared.

Wernher von Braun

NASA Image and Video Library

1965-05-25

This image depicts the tension in the Launch Control Center of the Launch Complex 37 at Cape Canaveral, Florida, during the SA-8 on May 25, 1965. Pointing, center is Dr. Kurt Debus, Director, Launch Operations Directorate, MSFC. To the right is Dr. Hans Gruene, Deputy Director, Launch Operations Directorate, MSFC; Dr. von Braun, Director, Marshall Space Flight Center (MSFC); and leaning, Dr. Eberhard Rees, Director, Deputy Director for Research and Development, MSFC. The SA-8 mission, with a Saturn I launch vehicle, made the first night launch and deployed Pegasus II, micrometeoroid detection satellite.

Fibroblast growth factor-10 signals development of von Brunn's nests in the exstrophic bladder

PubMed Central

Eastman, Rocky; Leaf, Elizabeth M.; Zhang, Dianzhong; True, Lawrence D.; Sweet, Robert M.; Seidel, Kristy; Siebert, Joseph R.; Grady, Richard; Mitchell, Michael E.

2010-01-01

von Brunn's nests have long been recognized as precursors of benign lesions of the urinary bladder mucosa. We report here that von Brunn's nests are especially prevalent in the exstrophic bladder, a birth defect that predisposes the patient to formation of bladder cancer. Cells of von Brunn's nest were found to coalesce into a stratified, polarized epithelium which surrounds itself with a capsule-like structure rich in types I, III, and IV collagen. Histocytochemical analysis and keratin profiling demonstrated that nested cells exhibited a phenotype similar, but not identical, to that of urothelial cells of transitional epithelium. Immunostaining and in situ hybridization analysis of exstrophic tissue demonstrated that the FGF-10 receptor is synthesized and retained by cells of von Brunn's nest. In contrast, FGF-10 is synthesized and secreted by mesenchymal fibroblasts via a paracrine pathway that targets basal epithelial cells of von Brunn's nests. Small clusters of 10pRp cells, positive for both FGF-10 and its receptor, were observed both proximal to and inside blood vessels in the lamina propria. The collective evidence points to a mechanism where von Brunn's nests develop under the control of the FGF-10 signal transduction system and suggests that 10pRp cells may be the original source of nested cells. PMID:20719973

Teaching, Learning and Education in Late Modernity: The Selected Works of Peter Jarvis. World Library of Educationalists

ERIC Educational Resources Information Center

Jarvis, Peter

2011-01-01

Professor Peter Jarvis has spent over 30 years researching, thinking and writing about some of the key and enduring issues in education. He has contributed well over 30 books and 200 papers and chapters in books on learning theory, adult education and learning, continuing professional education, nurse education, primary school education, distance…

Pratt & Whitney Advanced Ducted Propulsor (ADP) Engine Test in 40x80ft w.t.: Engineers Peter

NASA Technical Reports Server (NTRS)

1993-01-01

Pratt & Whitney Advanced Ducted Propulsor (ADP) Engine Test in 40x80ft w.t.: Engineers Peter Zell (left) and Dr Clifton Horne (right) are shown preparing a laser light sheet for a flow visualization test. Shown standing in the nacelle of the ADP is John Girvin, senior test engineer for Pratt & Whitney.

In Defense of the Defense: The Continuing Political Value of Denial of Enemy Aims

DTIC Science & Technology

2013-01-01

Propositions, 8–19, 28–40. 4. Carl von Clausewitz, On War, ed. and trans. Michael Howard and Peter Paret ( Prince - ton, NJ: Princeton University Press, 1976), 81...From Machiavelli to the Nuclear Age (Princeton, NJ: Princeton University Press, 1986), 148, 154–55, 159, 161, 168–70, 174–75. 40. Clausewitz, On War

Forest inventory: Peter T. Johnson Wildlife Mitigation Unit, Craig Mountain, Idaho. Final Report.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Narolski, Steven W.

The primary objective of this report is to determine the quantity and quality of existing forest habitat types on the 59,991-acre Peter T. Johnson Wildlife Mitigation Unit (WMU). Products from this effort include a description of the ecological condition, a map of habitat types, and an inventory of forest resources on the WMU lands. The purpose of this and other resource inventories (plant and wildlife) is to assess the current resources condition of the WMU and to provide necessary information to generate a long-term management for this area.

PEOPLE IN PHYSICS: Interview with Professor Peter Kalmus

NASA Astrophysics Data System (ADS)

Wilson, Conducted by Catherine

1998-07-01

Peter Kalmus was born in 1933. He obtained his BSc and PhD at University College London. After a further period as a Research Associate he spent some years in America. He has been at Queen Mary and Westfield College (formerly just QMC) of the University of London since 1964, becoming Professor in 1978 and Head of Department from 1992 to 1997. He is Vice President of the Institute of Physics and also of the Royal Institution. Professor Kalmus is a well-known popularizer of physics and is active in the public understanding of science. He is a former Physics President of the British Association. He is an eminent researcher and received the Rutherford Medal and Prize for his contributions to the discovery of the W and Z particles, the carriers of the weak force. During 1998-99 he will be delivering the Institute's Schools and Colleges Lecture `Particles and the Universe', which will incorporate some of the new IOP 16-19 Physics curriculum material, in many UK locations.

Writing the True Self: Case Studies of Eng 101 Students Responding to a Peter Elbow-Inspired Curriculum

ERIC Educational Resources Information Center

Stansell, Jon W.

2012-01-01

My fulfillment in life comes through helping others develop their potential, work through their troubles, and follow their dreams. I have found that my college students embrace this aspect as I teach them expressive, author-involved writing. Peter Elbow's work asserts that this type of writing fits into his theory of personal development, which is…

Pratt & Whitney Advanced Ducted Propulsor (ADP) Engine Test in 40x80ft w.t.: Engineers Peter

NASA Technical Reports Server (NTRS)

1993-01-01

Pratt & Whitney Advanced Ducted Propulsor (ADP) Engine Test in 40x80ft w.t.: Engineers Peter Zell (left) and Dr Clifton Horne (right) are shown preparing for a laser light sheet for a flow visualization test. Shown standing in the nacelle of the ADP is John Girvin, senior test engineer for Pratt & Whitney.

Genetics Home Reference: von Hippel-Lindau syndrome

MedlinePlus

... more common in particular ethnic groups? Genetic Changes Mutations in the VHL gene cause von Hippel-Lindau ... dividing too rapidly or in an uncontrolled way. Mutations in this gene prevent production of the VHL ...

Serials Management in the Electronic Era: Papers in Honor of Peter Gellatly, Founding Editor of "The Serials Librarian."

ERIC Educational Resources Information Center

Cole, Jim, Ed.; Williams, James W., Ed.

This book assesses progress and technical changes in the field of serials management and anticipates future directions and challenges for librarians. The book consists of 18 chapters: (1) "Introduction" (Jim Cole and James W. Williams); (2) "Peter Gellatly--Editor with a Deft Touch" (Ruth C. Carter); (3) "The "Deseret…

A new species of the genus Diplocentrus Peters, 1861 (Scorpiones, Diplocentridae) from Oaxaca, Mexico

PubMed Central

Santibáñez-López, Carlos Eduardo

2014-01-01

Abstract A new species of the genus Diplocentrus Peters, 1861 is described, based on several specimens collected in the Mexican state of Oaxaca. It is characterized by a high telotarsal spiniform setae count (4-5/5:5/6:6/6:6/6-7), and the pectinal tooth counts of 12–15, mode = 13 (male) or 11–13, mode = 12 (female). With the description of this species, the diversity of the genus is increased to 51 species in Mexico. PMID:24899864

A rapid method to visualize von willebrand factor multimers by using agarose gel electrophoresis, immunolocalization and luminographic detection.

PubMed

Krizek, D R; Rick, M E

2000-03-15

A highly sensitive and rapid clinical method for the visualization of the multimeric structure of von Willebrand Factor in plasma and platelets is described. The method utilizes submerged horizontal agarose gel electrophoresis, followed by transfer of the von Willebrand Factor onto a polyvinylidine fluoride membrane, and immunolocalization and luminographic visualization of the von Willebrand Factor multimeric pattern. This method distinguishes type 1 from types 2A and 2B von Willebrand disease, allowing timely evaluation and classification of von Willebrand Factor in patient plasma. It also allows visualization of the unusually high molecular weight multimers present in platelets. There are several major advantages to this method including rapid processing, simplicity of gel preparation, high sensitivity to low concentrations of von Willebrand Factor, and elimination of radioactivity.

Wernher von Braun: Reflections on His Contributions to Space Exploration

NASA Technical Reports Server (NTRS)

Goldman, Arthur E.

2012-01-01

In 1950, Dr. Wernher von Braun and approximately 100 of his team members came to Huntsville, Alabama, to begin work with the Army on what would later become America's historic space program. He would later serve as the first director of the Marshall Space Flight Center and led the development of the Saturn V launch vehicle that launched seven crewed American mission to the moon, as well as America s first space station, Skylab. Von Braun is best known for his team s technical achievements. He realized his dream of exploring outer space by helping place humans on the moon. His engineering and managerial talent during the Apollo era had contributed to a technological revolution. He was by all accounts a good engineer, but he was only one among many. What set Von Braun apart were his charisma, his vision, and his leadership skills. He inspired loyalty and dedication in the people around him. He understood the importance of communicating his vision to his team, to political and business leaders and the public. Today, the Marshall Center continues his vision by pursuing engineering and scientific projects that will continue to open space to exploration. This presentation will discuss Von Braun's impact on Huntsville, the Marshall Center, the nation and the world and look at his contributions in context of where world space exploration is today.

Update zum klinischen Einsatz von Inhibitoren mutierter Phosphokinasen beim Melanom.

PubMed

Cosgarea, Ioana; Ritter, Cathrin; Becker, Jürgen C; Schadendorf, Dirk; Ugurel, Selma

2017-09-01

Die Behandlungsstrategie beim metastasierten Melanom hat sich mit der Identifizierung therapeutisch angreifbarer molekularer Zielstrukturen innerhalb zellulärer Signalwege radikal geändert. Durch die Zulassung von Substanzen, die gezielt an den zentralen Schaltmolekülen, den Phosphokinasen, angreifen, können diese Signalwege selektiv abgeschaltet werden. Dies ist insbesondere bei denjenigen Tumoren von Interesse, deren Signalwege durch aktivierende Mutationen der für die Schaltmoleküle kodierenden Gene konstitutiv aktiviert sind. Aktuell ist diese therapeutische Strategie insbesondere für Patienten bedeutsam, deren Melanome eine Mutation im BRAF-Gen aufweisen. Diese Patienten können durch eine Kombinationstherapie aus Inhibitoren der Phosphokinasen BRAF und MEK langfristig mit sehr guter Krankheitskontrolle behandelt werden. Unter dieser Kombinationstherapie wird aktuell ein progressionsfreies Überleben von über zehn Monaten und ein Gesamtüberleben von mehr als zwei Jahren bei guter Lebensqualität erzielt. Da unter längerfristiger Therapie mit Kinaseinhibitoren jedoch bei einem Großteil der Patienten eine Resistenzbildung auftritt, sind aktuelle klinische Therapiestudien auf die Suche nach geeigneten Kombinationspartnern unter Blockierung anderer Signalwege oder unter Aktivierung der T-Zell-vermittelten Immunantwort ausgerichtet. Der vorliegende Übersichtsartikel stellt sowohl die aktuell verfügbaren als auch die in der klinischen Testung befindlichen zukünftigen Optionen der zielgerichteten Therapie des Melanoms dar. © 2017 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.

Wernher von Braun

NASA Image and Video Library

1959-03-01

In this photo, Director of the U.S. Army Ballistic Missile Agency's (ABMA) Development Operations Division, Dr. Wernher von Braun, and Director of Missile Firing Division, Dr. Kurt Debus, are shown with unidentified individuals, discussing two components that would make up the Pioneer IV Lunar Probe. The mercury batteries (left) were used to power the radio transmitter, cosmic radiation counter and other instruments in Pioneer IV. The conical shroud placed over the instruments of Pioneer IV was plated with gold to improve conductivity. The metal surface also served as the anterna for the probe's instruments signaling back to the Earth receiving stations.

"The physician as poet" review of: Pereira, Peter Saying the World

PubMed Central

Weishaus, Joel

2006-01-01

Peter Pereira is a family physician and a poet. I weave excerpts from Dr. Pereira's poems into a brief history of medicine's mythological and historical roots, beginning with the Egyptian god Thoth, and the Greek physician Hippocrates. Along the way, I touch on the European Middle Ages and the Islamic World. Finally, I quote poet-critic T.S. Eliot, who was an early influence on Dr. Pereira's decision to become a poet, and contemporary physician-poets Rafael Campo and William Carlos Williams. I end by placing Dr. Pereira, whose practice is oriented toward immigrant families, in his indigenous Pacific Northwest, arguing that being both physician and poet helps Pereira to live in a world that is both intimately human and naturally impersonal.

The British Interplanetary Society - Val Cleaver and Wernher von Braun

NASA Astrophysics Data System (ADS)

Willhite, I. P.

This article is concerned with the early relationship between Wernher von Braun and the British Interplanetary Society (BIS). The BIS/Wernher von Braun/Val Cleaver correspondence files located here at the US Space & Rocket Center in Huntsville, Alabama are unparalleled. As one reads the stimulating comments between Cleaver and von Braun, the need to share their thoughts prevails. Following is an excerpt from one letter that whets ones appetite for more. 10 June 1951 Cleaver writes, “I'm so glad you enjoyed my last letter, and look forward to your promised further contribution to our discussion of the ethics of science in general and astronautics in particu- lar. As regards the one particular point on which you found yourself unable to hold your fire, I should say there are really two distinct issues at stake:. . .” This article attempts to represent the best of the letters as they goad each other on scientific principles, means to prevent wars, and other philosophic ideas.

Virchow's triad: Kussmaul, Quincke and von Recklinghausen.

PubMed

Stanifer, John W

2016-02-01

For most of the 19th century, Germany was the centre of the medical world. From there the most innovating research came and many of the physicians of that era are known to nearly every medical student and physician of today. Virchow, Kussmaul, Quincke, von Recklinghausen, Müller and Schönlein are familiar names in today's medicine but insofar as they are merely eponyms associated with signs, symptoms, disease and anatomy. The story of their lives, their research and their influence on each other has been little examined. This is an essay about Virchow's relationship with his mentors Müller and Schönlein and how these relationships shaped the development of Kussmaul, Quincke and von Recklinghausen as students of Virchow and their work in medicine and clinical observation after leaving Virchow's laboratory. © The Author(s) 2014.

Von eingebetteten Systemen zu Cyber-Physical Systems

NASA Astrophysics Data System (ADS)

Wedde, Rorst F.; Lehnhoff, Sebastian; Rehtanz, Christian; Krause, Olav

Das Hauptanliegen des Papiers ist, ein Paradigma für Probleme mit neuartigen Integrationsanforderungen für Forschung und Entwicklung in verteilten eingebetteten Echtzeitsystemen zu motivieren und vorzustellen, nämlich den Begriff Cyber-Physical Systems. Bei einer in letzter Zeit stark zunehmenden Anzahl von Realzeitanwendungen können ohne die Berücksichtigung solcher Forderungen keine praktisch brauchbaren Lösungen erwartet werden. Einige Anwendungsfelder werden angesprochen. Im Einzelnen werden dann für Elektroautos, die mit erneuerbaren Energien betrieben werden sollen, einerseits die Management-, verteilte Verhandlungs- und Verteilungsprobleme der benötigten Energie in einem bottom-up Ansatz gelöst. Andererseits wird als Teil unserer Projektarbeit die Bereitstellung von Reserveenergie für den allgemeinen Bedarf durch Autobatterien vorgestellt. Es zeigt sich, dass dies effizienter und wesentlich kurzfristiger in unserem verteilten Vorgehen geschehen kann als in traditionellen Verfahren.

Aufnahme, Analyse und Visualisierung von Bewegungen nativer Herzklappen in-vitro

NASA Astrophysics Data System (ADS)

Weiß, Oliver; Friedl, Sven; Kondruweit, Markus; Wittenberg, Thomas

Die hohe Zahl an Transplantationen von Herzklappen und viele nötige Re-Operationen machen eine detaillierte Analyse der Strömungen und Klappenbewegungen klinisch interessant. Ein neuer Ansatz ist hierbei der Einsatz von Hochgeschwindigkeitskameras um Bewegungsabl äufe der Herzklappen beobachten und auswerten zu können. Die hohen Datenraten erfordern allerdings eine möglichst automatisierte Analyse und möglichst komprimierte Darstellung des Schwingungsverhaltens. In dieser Arbeit wird ein Ansatz vorgestellt, bei dem Bewegungen nativer Herzklappen in-vitro aufgenommen, analysiert und kompakt visualisiert werden.

Filling South Korea’s Counterinsurgency Gap: Looking Ahead to Potential Problems Facing South Korea in the Aftermath of North Korea’s Collapse

DTIC Science & Technology

2012-05-17

groups. In 1167, a young civil administrator humiliated a respected general, Jeong Jung -bu, by burning his long beard with a candle during a royal...90 Carl von Clausewitz, On War, edited and translated by Michael Howard and Peter Paret...from each other to deter the effect of synchronization . However, what matters most is achieving strategic aims through the efficient arrangement of

The Concept of Design: Are We off Track?

DTIC Science & Technology

2012-06-15

Andrews, Henry Mintzberg, Ludwig von Bertalanffy, Thomas Kuhn, Horst Rittel, Melvin Webber, Dietrich Dörner, and Peter Senge listed below cement a...perspective. The terms, concepts, and intellectual accessories presented in this chapter cement a deeper appreciation and understanding of design as a...thinking. Creative thinking involves generating something new or original. It involves the skills of flexibility, originality, fluency , elaboration

Proceedings of the European ISTVS Conference (6th) , OVK Symposium (4th), On ’Off Road Vehicles in Theory and Practice’ , Held at Vienna, Austria on 28-30 September 1994 in Vienna, Austria. Volume 1.

DTIC Science & Technology

1994-09-30

The Commander-in-Chief of the British troops, General Sir Peter de la Billiere, reported that each vehicle of the Tenth Transport Regiment covered 400...Simulation des Reifenprofileinflusses fuir die Gelaindebeweglichkeit von Fahrzeugen C. W. FERVERS IKK-University of German Armed Forces Hamburg, Germany...of the Process) 731 Experimentelle und theoretische Analyse kohaisiven Erdreichs beim Verschiebevorgang (Optimierung des Vorganges) A. JARZEBOWSKI, J

Analog of the Peter-Weyl expansion for Lorentz group

NASA Astrophysics Data System (ADS)

Perlov, Leonid

2015-11-01

The expansion of a square integrable function on SL(2, C) into the sum of the principal series matrix coefficients with the specially selected representation parameters was recently used in the Loop Quantum Gravity [C. Rovelli and F. Vidotto, Covariant Loop Quantum Gravity: An Elementary Introduction to Quantum Gravity and Spinfoam Theory (Cambridge University Press, Cambridge, 2014) and C. Rovelli, Classical Quantum Gravity 28(11), 114005 (2011)]. In this paper, we prove that the sum used originally in the Loop Quantum Gravity: ∑ j = 0 ∞ ∑ |m| ≤ j ∑ |n| ≤ j Dj m , j n ( j , τ j ) ( g ) , where j, m, n ∈ Z, τ ∈ C is convergent to a function on SL(2, C); however, the limit is not a square integrable function; therefore, such sums cannot be used for the Peter-Weyl like expansion. We propose the alternative expansion and prove that for each fixed m: ∑ j = m ∞ D j m , j m ( j , τ j ) ( g ) is convergent and that the limit is a square integrable function on SL(2, C). We then prove the analog of the Peter-Weyl expansion: any ψ(g) ∈ L2(SL(2, C)) can be decomposed into the sum: ψ ( g ) = ∑ j = m ∞ j 2 ( 1 + τ 2 ) c j m m D j m , j m ( j , τ j ) ( g ) , with the Fourier coefficients c j m m = ∫ S L ( 2 , C ) ψ ( g ) Dj m , j m j , τ j ( g ) ¯ d g , g ∈ SL(2, C), τ ∈ C, τ ≠ i, - i, j, m ∈ Z, m is fixed. We also prove convergence of the sums ∑ j = |p| ∞ ∑ |m| ≤ j ∑ |n| ≤ j dp m /j 2 Dj m , j n ( j , τ j ) ( g ) , where d|p| m /j 2 = ( j + 1 ) /1 2 ∫ S U ( 2 ) ϕ ( u ) D|p| m /j 2 ( u ) ¯ d u is ϕ(u)'s Fourier transform and p, j, m, n ∈ Z, τ ∈ C, u ∈ SU(2), g ∈ SL(2, C), thus establishing the map between the square integrable functions on SU(2) and the space of the functions on SL(2, C). Such maps were first used in Rovelli [Class. Quant. Grav. 28, 11 (2011)].

Paleozoic fluid history of the Michigan Basin: Evidence from dolomite geochemistry in the Middle Ordovician St. Peter Sandstone

DOE Office of Scientific and Technical Information (OSTI.GOV)

Winter, B.L.; Johnson, C.M.; Simo, J.A.

1995-04-03

The isotope (Sr and O) and elemental (Mg, Ca, Mn, Fe, and Sr) compositions of the various dolomites in the Middle Ordovician St. Peter Sandstone in the Michigan Basin are determined and the variations are modeled in terms of fluid-rock interaction or as mixing relations. These geochemical models, combined with the paragenetic sequence of the dolomites and late anhydrite cement, suggest the existence of at least four distinct diagenetic fluids in the St. Peter Sandstone during the paleozoic. Fluid 1 has a composition consistent with a modified older (pre-Middle Ordovician) seawater origin, which indicates that the flow path for thismore » fluid had a major upward component. This fluid resulted in the first and volumetrically most important burial dolomitization event, producing dolomite in both carbonate and quartz sandstone lithofacies in the St. Peter Sandstone. Fluid 2 has a composition consistent with a modified Middle to early Late Ordovician seawater origin, suggesting a major downward component for fluid flow. Fluid 2 produced dolomite cement in the carbonate lithofacies that postdates Fluid 1 dolomite. The composition of Fluid 3 is best interpreted to reflect a heated, deep basinal brine that had previously interacted with the K-feldspar-rich rocks near the Cambrian-Precambrian unconformity in the Michigan Basin, indicating a major upward component for fluid flow. Fluid 3 produced dolomite cement in quartz sandstone lithofacies that postdates Fluid 1 dolomite. Fluid 4 resulted in precipitation of late anhydrite in fractures. The {sup 87}Sr/{sup 86}Sr ratio of the anhydrite is consistent with Fluid 4 originating as a dilute fluid that interacted extensively with Silurian gypsum in the Michigan Basin; this indicates that the flow path of Fluid 4 had a major downward component.« less

Saving Time and Money in Michigan: Peter J. Young Talks about Professional Development, Parent Communication, Funding, and Partnerships

ERIC Educational Resources Information Center

Branzburg, Jeffrey

2007-01-01

This article presents an interview with Peter J. Young, Director of Technology at Rockford Public Schools in Michigan. In the interview, Young talked about how his district has done a lot more automation to integrate its disparate systems. He also discussed how they streamline their systems, how parents and community benefit from these efforts,…

CO{sub 2} Injectivity, Storage Capacity, Plume Size, and Reservoir and Seal Integrity of the Ordovician St. Peter Sandstone and the Cambrian Potosi Formation in the Illnois Basin

DOE Office of Scientific and Technical Information (OSTI.GOV)

Leetaru, Hannes; Brown, Alan; Lee, Donald

2012-05-01

The Cambro-Ordovician strata of the Illinois and Michigan Basins underlie most of the states of Illinois, Indiana, Kentucky, and Michigan. This interval also extends through much of the Midwest of the United States and, for some areas, may be the only available target for geological sequestration of CO{sub 2}. We evaluated the Cambro-Ordovician strata above the basal Mt. Simon Sandstone reservoir for sequestration potential. The two targets were the Cambrian carbonate intervals in the Knox and the Ordovician St. Peter Sandstone. The evaluation of these two formations was accomplished using wireline data, core data, pressure data, and seismic data frommore » the USDOE-funded Illinois Basin Decatur Project being conducted by the Midwest Geological Sequestration Consortium in Macon County, Illinois. Interpretations were completed using log analysis software, a reservoir flow simulator, and a finite element solver that determines rock stress and strain changes resulting from the pressure increase associated with CO{sub 2} injection. Results of this research suggest that both the St. Peter Sandstone and the Potosi Dolomite (a formation of the Knox) reservoirs may be capable of storing up to 2 million tonnes of CO{sub 2} per year for a 20-year period. Reservoir simulation results for the St. Peter indicate good injectivity and a relatively small CO{sub 2} plume. While a single St. Peter well is not likely to achieve the targeted injection rate of 2 million tonnes/year, results of this study indicate that development with three or four appropriately spaced wells may be sufficient. Reservoir simulation of the Potosi suggest that much of the CO{sub 2} flows into and through relatively thin, high permeability intervals, resulting in a large plume diameter compared with the St. Peter.« less

Some single-piston closed-cycle machines and Peter Tailer's thermal lag engine

DOE Office of Scientific and Technical Information (OSTI.GOV)

West, C.D.

1993-01-01

Peter Tailer has devised, built, and operated a beautifully simple engine with a closed working gas cycle, external heating, and only a single piston. The aim of this paper is to cast some light on the possible modes of operation for his machine. The methods develops to analyze certain aspects of Stirling cycle engines, and especially the thermodynamic losses incurred in systems that are neither perfectly isothermal nor perfectly adiabatic, can be applied to Tailer's system. The results identify two idealized cycles fr such machines; relate those cycles to a single piston, ported cylinder machine proposed earlier; and offer amore » possible explanation for the success of the thermal lag engine.« less

Bilateral anterior segment dysgenesis with the presumed Peters' anomaly in a cat.

PubMed

Park, Sangwan; Kim, Kiwoong; Kim, Youngbeum; Seo, Kangmoon

2018-02-20

A seven-month-old female domestic shorthaired cat was presented for buphthalmos in the right eye and corneal cloudiness in the left eye. Full ophthalmic examinations were performed for both eyes and enucleation was done for the right nonvisual eye. Congenital glaucoma caused by anterior segment dysgenesis was confirmed for the right eye. In the left eye, slit-lamp examination revealed focal corneal edema with several iris strands from iris collarette to the affected posterior corneal surfaces. Circular posterior corneal defect was suggested to be the cause of edema. Goniodysgenesis, additionally, was identified. Taken together, the diagnosis of Peters' anomaly which is a subtype of anterior segment dysgenesis was suggested in the left eye.

Von Donuts und Zucker: Mit Neutronen biologische Makromoleküle erforschen

NASA Astrophysics Data System (ADS)

May, Roland P.

2003-05-01

Für die Erforschung von Biomolekülen bieten Neutronen einzigartige Eigenschaften. Vor allem ihre unterschiedliche Wechselwirkung mit dem natürlichen Wasserstoff und seinem schweren Isotop Deuterium ermöglicht tiefe Einblicke in Struktur, Funktion und Dynamik von Proteinen, Nukleinsäuren und Biomembranen. Bei vielen Fragestellungen zur Strukturaufklärung gibt es kaum oder keine Alternative zum Neutron. Das Institut Laue-Langevin trägt Bahnbrechendes zum Erfolg der Neutronen-Methoden in der Biologie bei.

Peter Fensham--Head, Heart and Hands (on) in the Service of Science Education and Social Equity and Justice

ERIC Educational Resources Information Center

Gunstone, Richard

2009-01-01

When Peter Fensham was appointed to the new Chair of Science Education at Monash University in 1967 he was the first Professor of Science Education in Australia, and, we think, may well have been the first such professor anywhere in the world outside USA. Over the subsequent 40+ years he has made/still makes remarkable and diverse contributions to…

The Global Food Crisis: Causes and Solutions. Statement of Peter McPherson before the Senate Foreign Relations Committee

ERIC Educational Resources Information Center

National Association of State Universities and Land-Grant Colleges, 2008

2008-01-01

This paper presents Peter McPherson's statement before the Senate Foreign Relations Committee. He begins by saying that people have an immediate problem that must be addressed, hopefully in a way that does not complicate long-term solutions. They also have a long-term and more complicated agricultural problem that the world has neglected over many…

The von Auwers reaction - history and synthetic applications.

PubMed

Dumeunier, Raphaël; Jaeckh, Simon

2014-01-01

Dienones obtained from the facile dearomatization of phenols, can be further transformed to semi-benzenes prone to rearomatize in clean, but sometimes unexpected, fashion. Over a hundred years ago, K. von Auwers found that adding Grignards on dienones would lead spontaneously to subsequent dehydration and a novel aromatizing rearrangement. This reaction was ignored for 50 years before Melvin Newman re-investigated these findings, studied the mechanism, and developed variations on the same theme. Since then, despite the tremendous potential of the reactions, those studies were only rarely mentioned, before finally falling into oblivion. This review aims to provide the reader with a detailed history and comprehensive bibliography of the von Auwers rearrangement, some of its synthetic applications, and new unpublished material in the hope to open new perspectives on this forgotten reaction.

Communication; A Discussion at the Nobel Conference (5th, Gustavus Adolphus College, St. Peter, Minnesota, January 8-9, 1969).

ERIC Educational Resources Information Center

Roslansky, John D., Ed.

This book consists of five lectures on communication given at the fifth Nobel Conference. Leroy G. Augenstein explores the positive and negative consequences of man's increasing capacity to manipulate and control the human mind. Peter Marler demonstrates that all the elements necessary for a communication system to qualify as a language exist…

Dr. von Braun Tours the North American Aviation

NASA Technical Reports Server (NTRS)

1962-01-01

Dr. Wernher von Braun, Director of the Marshall Space Flight Center (MSFC), during his tour of the Space information Division of North American Aviation (NAA) in Downey, California, where the Saturn SII stage was developed.

Dr. von Braun tours the North American Aviation

NASA Technical Reports Server (NTRS)

1962-01-01

Dr. Wernher von Braun, Director of the Marshall Space Flight Center (MSFC), during his tour of the Space Information Division of North American Aviation (NAA) in Downey, California, where the Saturn SII stage was developed.

Design of inside cut von koch fractal UWB MIMO antenna

NASA Astrophysics Data System (ADS)

Tharani, V.; Shanmuga Priya, N.; Rajesh, A.

2017-11-01

An Inside Cut Hexagonal Von Koch fractal MIMO antenna is designed for UWB applications and its characteristics behaviour are studied. Self-comparative and space filling properties of Koch fractal structure are utilized in the antenna design which leads to the desired miniaturization and wideband characteristics. The hexagonal shaped Von Koch Fractal antenna with Defected Ground Structure (DGS) is designed on FR4 substrate with a compact size of 30mm x 20mm x 1.6mm. The antenna achieves a maximum of -44dB and -51dB at 7.1GHz for 1-element and 2-element case respectively.

Elliptical Instability of Rotating Von Karman Street

NASA Astrophysics Data System (ADS)

Stegner, A.; Pichon, T.; Beunier, M.

Clouds often reveal a meso-scale vortex shedding in the wake of mountainous islands. Unlike the classical bi-dimensional Von-Karman street, these observed vortex street are affected by the earth rot ation and vertical stratification. Theses effects could induce a selective destabilization of anticyclonic vortices. It is well known that inertial instability (also called centrifugal instability) induce a three- dimensional destabilization of anticyclonic structures when the absolute vorticity is larger than the local Coriolis parameter. However, we have shown, by the mean of laboratory experiments, that it is a different type of instability which is mainly responsible for asymmetric rotating Von-Karman street. A serie of experiments were performed to study the wake of a cylinder in a rotating fluid, at medium Reynolds number and order one Rossby number. We have shown that the vertical structure of unstable anticyclonic vortices is characteristic of an elliptical instability. Besides, unlike the inertial instability, the vertical unstable wavelength depends on the Rossby number.

Inattentional blindness and the von Restorff effect.

PubMed

Schmidt, Stephen R; Schmidt, Constance R

2015-02-01

Sometimes we fail to notice distinctive or unusual items (inattentional blindness), while other times we remember distinctive items more than expected items (the von Restorff effect). A three-factor framework is presented and tested in two experiments in an attempt to reconcile these seemingly contradictory phenomena. Memory for different types of unexpected stimuli was tested after an easy or difficult Stroop color-naming task. Highly arousing taboo words were well remembered even when the difficult Stroop task limited attentional resources. However, a conceptual isolation effect was only observed when the nature of the category change was highlighted by the Stroop task, the Stroop task was easy, and/or the isolated targets enjoyed a retrieval advantage relative to comparison targets. As proposed in the three-factor framework, the arousing qualities of the stimuli, the attentional demands of the primary task, and the relevance of isolated features at encoding and retrieval combine to produce inattentional blindness and the von Restorff effect.

Yes! There is an ethics of care: an answer for Peter Allmark.

PubMed Central

Bradshaw, A

1996-01-01

This paper is a response to Peter Allmark's thesis that 'there can be no "caring" ethics'. It argues that the current preoccupation in nursing to define an ethics of care is a direct result of breaking nursing tradition. Subsequent attempts to find a moral basis for care, whether from subjective experimental perspectives such as described by Noddings, or from rational and detached approaches derived from Kant, are inevitably flawed. Writers may still implicitly presuppose a concept of care drawn from the Judaeo-Christian tradition but without explicit recourse to its moral basis nursing is left rudderless and potentially without purpose. The very concept of 'care' cut off from its roots becomes a meaningless term without either normative or descriptive content. PMID:8932719

Von Willebrand's disease: case report and review of literature.

PubMed

Echahdi, Hanae; El Hasbaoui, Brahim; El Khorassani, Mohamed; Agadr, Aomar; Khattab, Mohamed

2017-01-01

Von Willebrand Disease (VWD) is the most common human inherited bleeding disorder due to a defect of Von Willebrand Factor (VWF), which a glycoprotein crucial for platelet adhesion to the subendothelium after vascular injury. VWD include quantitative defects of VWF, either partial (type 1 with VWF levels < 50 IU/dL) or virtually total (type 3 with undetectable VWF levels) and also qualitative defects of VWF (type 2 variants with discrepant antigenic and functional VWF levels). The most bleeding forms of VWD usually do not concern type 1 patients with the mildest VWF defects (VWF levels between 30 and 50IU/dL). Von willebrand factor is a complex multimeric protein with two functions: it forms a bridge between the platelets and areas of vascular damage and it binds to and stabilizes factor VIII, which is necessary for the clotting cascade. By taking a clinical history of bleeding (mucocutaneous bleeding symptoms suggestive of a primary haemostatic disorder, a quantitative or qualitative abnormality of VWF is possible) it is important to think about VWD and to make the appropriate diagnosis. If the VWD is suspected diagnostic tests should include an activated partial thromboplastin time, bleeding time, factor VIII: C Ristocetin cofactor and vWF antigen. Additional testing of ristocetin induced plattlet adhesion (RIPA) the multimeric structure and collagen binding test and genanalysis allow diagnosing the different types of von. Willebrand Disease. The treatment of choice in mild forms is the synthetic agent desmopressin. In patients with severe type 1, type 2B, 2N and type 3 or in people who do not response to desmopressin, the appropriate treatment is a factor VIII concentrate that is rich of VWF. We report a case of infant in 27-month-old boy who had been referred due to haemorrhagic shock. His birth histories, his familie's social history and developmental milestones were unremarkable. He was born at full term with no antenatal or perinatal complications. Prior to

Segmentierung von Aortenaneurysmen in CTA-Bildern mit dem statistischen Verfahren der Active Appearance Models

NASA Astrophysics Data System (ADS)

Greiner, Katharina; Egger, Jan; Großkopf, Stefan; Kaftan, Jens N.; Dörner, Ralf; Freisleben, Bernd

In diesem Beitrag werden Active Appearance Models (AAMs) zur Segmentierung der äußeren Kontur von Aortenaneurysmen eingesetzt. Diese Aufgabe ist wegen des geringen Kontrastes zum umliegenden Gewebe und des Aufbaus der teils thrombotisierten oder kalzifizierten Gefäßwände im Bereich eines Aneurysmas so komplex, dass sie aufgrund der Vielgestalt der Kontur in CT-Angiographie-Bildern die Verwendung eines statistischen Modells für Form und eingeschlossene Textur rechtfertigt. Für die Evaluation des Verfahrens wurden verschiedene statistische Modelle aus Schichten von neun CTA-Datensätzen trainiert und die Segmentierung anhand von Leave-One-Out-Tests überprüft.

Dr. von Braun Visits Huntsville Boys Club

NASA Technical Reports Server (NTRS)

1961-01-01

Dr. von Braun, Director of Marshall Space Flight Center (MSFC) and chairman of this year's United Givers Fund (UGF) drive at MSFC, takes time out from the problems of sending a man to the Moon to talk baseball with 11-year-old Randy Smith at the Huntsville Boys Club.

Gebrauch von Komplementärmedizin bei Patienten mit metastasierendem Melanom unter Therapie mit Ipilimumab innerhalb einer klinischen Studie.

PubMed

Huebner, Jutta; Mohr, Peter; Simon, Jan-Christoph; Fluck, Michael; Berking, Carola; Zimmer, Lisa; Loquai, Carmen

2016-05-01

In Deutschland wenden 40-90 % aller Krebspatienten Methoden der komplementären and alternativen Medizin (KAM) an. Bis dato gibt es kein Datenmaterial zum Einsatz der KAM bei Melanompatienten. Das Ziel unserer Studie war es, Daten über den Gebrauch, die Informationsquellen und Ziele von Patienten mit metastasierendem Melanom zu erfassen. Einhundertsechsundfünfzig Patienten aus 25 Studienzentren nahmen an der DecOG-MM-PAL Multibasket Studie teil. Die beteiligten Personen wurden auch gebeten, an einer Nebenstudie teilzunehmen, die ihren Gebrauch von KAM erfassen sollte. Dazu wurde während der Behandlung ein standardisierter Fragebogen zu genau festgelegten Zeitpunkten ausgeteilt. Insgesamt gingen 55 Fragebögen von 32 (21 %) Melanompatienten ein. Von diesen gaben 17 (53 %) ein Interesse an KAM an, und sieben (22 %) machten von KAM Gebrauch. Die Hauptinformationsquellen (31 %) waren Familienmitglieder und Freunde, gefolgt von Ärzten (19 %). Die Hauptgründe für die Anwendung von KAM waren die Stärkung des Immunsystems (41 %) und des Körpers (34 %). Nahrungsergänzungsmittel (Vitamine und Spurenelemente) wurden am häufigsten angewendet (28 %). Eine relativ hohe Anzahl an Patienten mit metastasierendem Melanom machte trotz Teilnahme an einer klinischen Studie von KAM Gebrauch. Wechselwirkungen könnten durch biologisch basierte KAM auftreten, und hier besonders bei immunmodulierenden KAM- Strategien. Um Risiken zu vermeiden, sollte die Kommunikation zwischen den Ärzten und den Patienten verbessert werden. © 2016 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.

Trizentrische Analyse von Kofaktoren und Komorbidität des Pyoderma gangraenosum.

PubMed

Jockenhöfer, Finja; Herberger, Katharina; Schaller, Jörg; Hohaus, Katja Christina; Stoffels-Weindorf, Maren; Ghazal, Philipp Al; Augustin, Matthias; Dissemond, Joachim

2016-10-01

Das Pyoderma gangraenosum (PG) ist eine seltene, inflammatorische destruktiv-ulzerierende neutrophile Erkrankung mit weitgehend unklarer Pathophysiologie. In dieser Studie wurden die potenziell relevanten Kofaktoren und Begleiterkrankungen von Patienten mit PG aus drei dermatologischen Wundzentren in Deutschland differenziert ausgewertet. Von den insgesamt 121 analysierten Patienten waren Frauen (66,9 %) häufiger betroffen als Männer. Das Alter der Patienten war 18-96 Jahre (Mittelwert [MW]: 59,8); die Wunden hatten eine Größe von 1-600 cm² (MW: 65,6 cm²) und waren überwiegend sehr schmerzhaft (VAS 1-10, MW: 7). Die Unterschenkel waren am häufigsten (71,9 %) betroffen. Bei 12 (9,9 %) Patienten bestanden chronisch entzündliche Darmerkrankungen (5,8 % Colitis ulcerosa; 4,1 % Morbus Crohn), bei 14,1 % der Patienten wurde eine Begleiterkrankung aus dem rheumatischen Formenkreis beschrieben. Neoplasien bestanden bei 20,6 % der Patienten, von denen 6,6 % als hämatologische und 14,1 % als solide Neoplasien klassifiziert wurden. Aus dem Kreis des metabolischen Syndroms wurde bei 69,4 % Patienten eine Adipositas, bei 57,9 % eine arterielle Hypertonie und bei 33,9 % ein Diabetes mellitus diagnostiziert. Diese Datenanalyse bestätigt Assoziationen des PG mit dem metabolischen Syndrom und mit Neoplasien, die zukünftig frühzeitig bei einer zielgerichteten Diagnostik der Patienten beachtet und behandelt werden sollten. © 2016 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.

(Never) Mind your p's and q's: Von Neumann versus Jordan on the foundations of quantum theory

NASA Astrophysics Data System (ADS)

Duncan, A.; Janssen, M.

2013-03-01

In 1927, in two papers entitled "On a new foundation [Neue Begründung] of quantum mechanics," Pascual Jordan presented his version of what came to be known as the Dirac-Jordan statistical transformation theory. Jordan and Paul Dirac arrived at essentially the same theory independently of one another at around the same time. Later in 1927, partly in response to Jordan and Dirac and avoiding the mathematical difficulties facing their approach, John von Neumann developed the modern Hilbert space formalism of quantum mechanics. We focus on Jordan and von Neumann. Central to the formalisms of both are expressions for conditional probabilities of finding some value for one quantity given the value of another. Beyond that Jordan and von Neumann had very different views about the appropriate formulation of problems in quantum mechanics. For Jordan, unable to let go of the analogy to classical mechanics, the solution of such problems required the identification of sets of canonically conjugate variables, i.e., p's and q's. For von Neumann, not constrained by the analogy to classical mechanics, it required only the identification of a maximal set of commuting operators with simultaneous eigenstates. He had no need for p's and q's. Jordan and von Neumann also stated the characteristic new rules for probabilities in quantum mechanics somewhat differently. Jordan and Dirac were the first to state those rules in full generality. Von Neumann rephrased them and, in a paper published a few months later, sought to derive them from more basic considerations. In this paper we reconstruct the central arguments of these 1927 papers by Jordan and von Neumann and of a paper on Jordan's approach by Hilbert, von Neumann, and Nordheim. We highlight those elements in these papers that bring out the gradual loosening of the ties between the new quantum formalism and classical mechanics. This paper was written as part of a joint project in the history of quantum physics of the Max Planck

Beyond victimhood. The struggle of Munich anatomist Titus von Lanz during National Socialism.

PubMed

Schütz, Mathias; Waschke, Jens; Marckmann, Georg; Steger, Florian

2015-09-01

The article analyzes the life and career of the anatomist Titus von Lanz (1897-1967) of Munich focusing on the period of National Socialism (NS). Von Lanz lost his position as an associate professor at the Anatomical Institute of Munich University because of his marriage to a "half-Jewish" woman in 1938. In contrast to most of his colleagues affected by National Socialist measures, von Lanz had opportunities to save his career and made extensive use of them. His story is that of a complicated struggle for the continuation of his work, involving a wide range of supporters from prestigious physicians to high-ranking National Socialist officials as well as the alienation of his colleagues at the Munich department of anatomy. The article tries to clarify these developments through the presentation of his social background, his supporters, his enemies, the research he conducted during NS and von Lanz' own remembrance of these developments from the post-war period. It aims at laying out a critical appreciation of his motives and actions, thereby contributing to the understanding of individual behavior of anatomists under NS. Copyright © 2015 Elsevier GmbH. All rights reserved.

An Alternative Perspective on von Winterfeldt et al.'s (1997) Test of Consequence Monotonicity

ERIC Educational Resources Information Center

Ho, Moon-Ho R.; Regenwetter, Michel; Niederee, Reinhard; Heyer, Dieter

2005-01-01

D. von Winterfeldt, N.-K. Chung, R. D. Luce, and Y. Cho (see record 1997-03378-008) provided several tests for consequence monotonicity of choice or judgment, using certainty equivalents of gambles. The authors reaxiomatized consequence monotonicity in a probabilistic framework and reanalyzed von Winterfeldt et al.'s main experiment via a…

[Scientific theoretical founding of medicine as a natural science by Hermann von Helmholtz (1821-1894)].

PubMed

Neumann, J N

1994-01-01

In this study an attempt will be made to discuss the epistemological problems in the theory and practice of modern technical medicine in the writings of Hermann von Helmholz. An inquiry into the relationship between von Helmholtz' thinking and the critical philosophy of Immanuel Kant is followed by the characteristics of von Helmholtz' philosophy of science which he himself called "empirical theory". The question of medicine as a science finally leads to the main problem of medical epistemology, viz., the relationship between theoretical knowledge and practice in medicine. In this context the anthropological dimension is brought into consideration.

Physical Realization of von Neumann Lattices in Rotating Bose Gases with Dipole Interatomic Interactions.

PubMed

Cheng, Szu-Cheng; Jheng, Shih-Da

2016-08-22

This paper reports a novel type of vortex lattice, referred to as a bubble crystal, which was discovered in rapidly rotating Bose gases with long-range interactions. Bubble crystals differ from vortex lattices which possess a single quantum flux per unit cell, while atoms in bubble crystals are clustered periodically and surrounded by vortices. No existing model is able to describe the vortex structure of bubble crystals; however, we identified a mathematical lattice, which is a subset of coherent states and exists periodically in the physical space. This lattice is called a von Neumann lattice, and when it possesses a single vortex per unit cell, it presents the same geometrical structure as an Abrikosov lattice. In this report, we extend the von Neumann lattice to one with an integral number of flux quanta per unit cell and demonstrate that von Neumann lattices well reproduce the translational properties of bubble crystals. Numerical simulations confirm that, as a generalized vortex, a von Neumann lattice can be physically realized using vortex lattices in rapidly rotating Bose gases with dipole interatomic interactions.

Some single-piston closed-cycle machines and Peter Tailer`s thermal lag engine

DOE Office of Scientific and Technical Information (OSTI.GOV)

West, C.D.

1993-06-01

Peter Tailer has devised, built, and operated a beautifully simple engine with a closed working gas cycle, external heating, and only a single piston. The aim of this paper is to cast some light on the possible modes of operation for his machine. The methods develops to analyze certain aspects of Stirling cycle engines, and especially the thermodynamic losses incurred in systems that are neither perfectly isothermal nor perfectly adiabatic, can be applied to Tailer`s system. The results identify two idealized cycles fr such machines; relate those cycles to a single piston, ported cylinder machine proposed earlier; and offer amore » possible explanation for the success of the thermal lag engine.« less

Identifikationsverfahren zur Analyse von EEG-Signalen bei Epilepsie mit Reaktions-Diffusions Netzwerken

NASA Astrophysics Data System (ADS)

Gollas, F.; Tetzlaff, R.

2007-06-01

Partielle Differentialgleichungen des Reaktions-Diffusions-Typs beschreiben Phänomene wie Musterbildung, nichtlineare Wellenausbreitung und deterministisches Chaos und werden oft zur Untersuchung komplexer Vorgänge auf den Gebieten der Biologie, Chemie und Physik herangezogen. Zellulare Nichtlineare Netzwerke (CNN) sind eine räumliche Anordnung vergleichsweise einfacher dynamischer Systeme, die eine lokale Kopplung untereinander aufweisen. Durch eine Diskretisierung der Ortsvariablen können Reaktions-Diffusions-Gleichungen häufig auf CNN mit nichtlinearen Gewichtsfunktionen abgebildet werden. Die resultierenden Reaktions-Diffusions-CNN (RD-CNN) weisen dann in ihrer Dynamik näherungsweise gleiches Verhalten wie die zugrunde gelegten Reaktions-Diffusions-Systeme auf. Werden RD-CNN zur Identifikation neuronaler Strukturen anhand von EEG-Signalen herangezogen, so besteht die Möglichkeit festzustellen, ob das gefundene Netzwerk lokale Aktivität aufweist. Die von Chua eingeführte Theorie der lokalen Aktivität Chua (1998); Dogaru und Chua (1998) liefert eine notwendige Bedingung für das Auftreten von emergentem Verhalten in zellularen Netzwerken. Änderungen in den Parametern bestimmter RD-CNN könnten auf bevorstehende epileptische Anfälle hinweisen. In diesem Beitrag steht die Identifikation neuronaler Strukturen anhand von EEG-Signalen durch Reaktions-Diffusions-Netzwerke im Vordergrund der dargestellten Untersuchungen. In der Ergebnisdiskussion wird insbesondere auch die Frage nach einer geeigneten Netzwerkstruktur mit minimaler Komplexität behandelt.

Interaktive Visualisierung von Abständen und Ausdehnungen anatomischer Strukturen für die Interventionsplanung

NASA Astrophysics Data System (ADS)

Rössling, Ivo; Cyrus, Christian; Dornheim, Lars; Hahn, Peter; Preim, Bernhard; Boehm, Andreas

Im Rahmen der Interventionsplanung muss der Chirurg therapierelevante Entscheidungen auf Basis räumlicher Relationen anatomischer Strukturen treffen. Interaktive 3D-Visualisierungen unterstützen diesen Prozess qualitativ. Quantitative Fragestellungen (Tumorausdehnung, Infiltrationstiefe, etc.) erfordern die Integration einer Bemaßung, deren Nutzen wesentlich von einer geeigneten Darstellung abhängt. In dieser Arbeit haben wir allgemeine Kriterien für die Eignung von Visualisierungen von Bemaßungen in interaktiven 3D-Szenen erarbeitet. Daran orientierend haben wir verschiedene Varianten der Darstellung von Abständen und Ausdehnungen anatomischer Strukturen betrachtet und ihr Erscheinungsbild hierzu zweckmäßig parametrisiert. Die Ausprägungen dieser Darstellungsparameter wurden in einer Studie auf ihre visuellen Wirkung hin an Chirurgen evaluiert. Es zeigte sich, dass die befragten Mediziner höchsten Wert auf Kohärenz und klare Zuordnung der Bemaßung setzten und überraschenderweise dafür sogar Abstriche in der direkten Lesbarkeit in Kauf nahmen.

Einstellung und Wissen von Lehramtsstudierenden zur Evolution - ein Vergleich zwischen Deutschland und der Türkei

NASA Astrophysics Data System (ADS)

Graf, Dittmar; Soran, Haluk

Es wird eine Untersuchung vorgestellt, in der Wissen und Überzeugungen von Lehramtsstudierenden aller Fächer zum Thema Evolution an zwei Universitäten in Deutschland und der Türkei erhoben worden sind. Die Befragung wurde in Dortmund und in Ankara durchgeführt. Es stellte sich heraus, dass ausgeprägte Defizite im Verständnis der Evolutionsmechanismen herrschen. Viele Studierende, insbesondere aus der Türkei, sind nicht von der Faktizität der Evolution überzeugt. Dies gilt sowohl für Studierende mit Fach Biologie als auch für Studierende mit anderen Fächern. Näher untersucht worden sind die Faktoren, die die Überzeugungen zur Evolution beeinflussen können, was ja in Anbetracht der hohen Ablehnungsrate der Evolution von besonderem Interesse ist. Das Vertrauen in die Wissenschaft spielt hierbei eine besondere Rolle: Wer der Wissenschaft vertraut, ist auch eher von der Evolution überzeugt, als diejenigen, die skeptisch gegenüber der Wissenschaft sind.

Identification of a His54Gln substitution in von Willebrand factor from a patient with defective binding of factor VIII.

PubMed

Rick, M E; Krizek, D M

1996-04-01

A patient with type 2N ("Normandy" variant) von Willebrand's disease is described. Her von Willebrand factor level was borderline low, while her factor VIII was markedly decreased to 7%. Her plasma von Willebrand factor demonstrated a decreased ability to complex with factor VIII in vitro, binding less than 10% when compared to normal plasma von Willebrand factor. The factor VIII released into the circulation after the patient received DDAVP had a shortened survival in vivo. Nucleotide sequence analysis revealed a T-to-A transition at nucleotide 2451 on both alleles. This transition results in a substitution of Gln for His at amino acid 54 in the mature subunit of von Willebrand factor.

Dr. Peter Cavanaugh Explains the Need and Operation of the FOOT Experiment

NASA Technical Reports Server (NTRS)

2003-01-01

This video clip is an interview with Dr. Peter Cavanaugh, principal investigator for the FOOT experiment. He explains the reasoning behind the experiment and shows some video clips of the FOOT experiment being calibrated and conducted in orbit. The heart of the FOOT experiment is an instrumented suit called the Lower Extremity Monitoring Suit (LEMS). This customized garment is a pair of Lycra cycling tights incorporating 20 carefully placed sensors and the associated wiring control units, and amplifiers. LEMS enables the electrical activity of the muscles, the angular motions of the hip, knee, and ankle joints, and the force under both feet to be measured continuously. Measurements are also made on the arm muscles. Information from the sensors can be recorded up to 14 hours on a small, wearable computer.

Guido von Pirquet: Austrian pioneer of astronautics

NASA Technical Reports Server (NTRS)

Sykora, F.

1977-01-01

The works of Guido von Pirquet, Austrian pioneer of rocketry, were assessed. Major emphasis was given to Pirquet's calculation of the route to Venus which in fact was followed by the first Russian rocket to Venus. Of interest also is Pirquet's valuable construction of a space station and his analysis of interstellar space flight.

Making sense of inequalities: a response to Peter Townsend.

PubMed

Klein, R

1991-01-01

This article addresses the continuing controversy generated by the Black Report on Inequalities in Health, published in Britain in 1980, in response to the defense offered by Professor Peter Townsend. The author argues that Townsend's riposte to the critics of the Black Report is flawed in at least two respects. First, Townsend fails to acknowledge that the Black Report was as much an exercise in policy advocacy as in scholarly analysis, making rather large assumptions about the links in the reasoning leading to its recommendations for a massive program of income redistribution. Second, Townsend's defense of Black's use of social class as its main tool for analyzing health inequalities dismisses too easily much of the evidence; for example, the effects of social mobility and the historical dimension. Moreover, by concentrating on social class, a heterogeneous category, analysis may ignore what is most relevant for policy-making: i.e., specific factors associated with specific forms of deprivation, located within social classes or particular geographical communities. It would therefore be more constructive if scholars were to accept and research this complexity, rather than defending the Black Report as though it were a definitive (not to say sacred) text.

Von Willebrand factor regulation of blood vessel formation.

PubMed

Randi, Anna M; Smith, Koval E; Castaman, Giancarlo

2018-06-04

Several important physiological processes, from permeability to inflammation to haemostasis, take place at the vessel wall and are regulated by endothelial cells (EC). Thus, proteins that have been identified as regulators of one process are increasingly found to be involved in other vascular functions. Such is the case for Von Willebrand Factor (VWF), a large glycoprotein best known for its critical role in haemostasis. In vitro and in vivo studies have shown that lack of VWF causes enhanced vascularisation, both constitutively and following ischemia. This evidence is supported by studies on blood outgrowth endothelial cells (BOEC) from patients with lack of VWF synthesis (type 3 von Willebrand disease [VWD]). The molecular pathways are likely to involve VWF binding partners, such as integrin αvβ3, and components of Weibel Palade bodies (WPB), such as Angiopoietin-2 and Galectin-3, whose storage is regulated by VWF; these converge on the master regulator of angiogenesis and endothelial homeostasis, vascular endothelial growth factor (VEGF) signalling. Recent studies suggest that the roles of VWF may be tissue-specific. The ability of VWF to regulate angiogenesis has clinical implications for a subset of VWD patients with severe, intractable gastrointestinal bleeding due to vascular malformations. In this article, we review the evidence showing that VWF is involved in blood vessel formation, discuss the role of VWF high molecular weight multimers in regulating angiogenesis, and the value of studies on BOEC in developing a precision medicine approach to validate novel treatments for angiodysplasia in congenital VWD and acquired von Willebrand syndrome. Copyright © 2018 American Society of Hematology.

Split Attention as Part of a Flexible Attentional System for Complex Scenes: Comment on Jans, Peters, and De Weerd (2010)

ERIC Educational Resources Information Center

Cave, Kyle R.; Bush, William S.; Taylor, Thalia G. G.

2010-01-01

Jans, Peters, and De Weerd (2010) examined the studies demonstrating that spatial attention can be split across 2 noncontiguous target locations. They find all these studies to be flawed and conclude that spatial attention only selects a single location at any given time. They do, however, suggest that there could be exceptional circumstances that…

Healing bodies or saving souls? Reverend Dr Peter Parker (1804-1888) as medical missionary.

PubMed

Fu, Louis

2016-05-01

The important role played by medical services in the preaching of the Gospel in China was undeniable. Anglo-American missionaries entered Canton in the early 18th century and introduced modern Western medicine to China. Reverend Dr Peter Parker, founder of medical missionaries to China, was more than that, far more advanced than his predecessors including Drs Pearson, Livingstone and Colledge. He was an enthusiastic missionary of exceptional ability and vigour as witnessed his labours at the Canton Ophthalmic Hospital. His 20 years in the medical field unexpectedly paved the way for his future career as a diplomat in the American Legation. © © IMechE 2014.

Untersuchung der Störwirkung von LTE auf SRD Anwendungen bei 868 MHz

NASA Astrophysics Data System (ADS)

Welpot, M.; Wunderlich, S.; Gaspard, I.

2014-11-01

Moderne Hausautomatisierungssysteme, Alarmanlagen oder auch Funk-Zugangssysteme in Haus und Automobil setzen auf frei nutzbare Frequenzen in ISM/SRD-Bändern. Die rasante Zunahme an privaten und kommerziell genutzten Applikationen im SRD-Band bei 868 MHz und der Ausbau der LTE-Mobilfunknetze im Frequenzbereich unterhalb von 1 GHz ("Digital Dividend") wirft zunehmend die Frage nach der Funkverträglichkeit dieser Systeme untereinander auf. Während die SRD-Funkmodule auf eine geringe Sendeleistung von ~ +14 dBm beschränkt sind (Ralf and Thomas, 2009), beträgt die maximale LTE-Sendeleistung im Uplink nach (ETSI-Norm, 2011) +23 dBm. Zusammen mit der Einführung von LTE im Frequenzbereich unterhalb 1 GHz als DSL-Ersatz vor allem in ländlichen Gebieten, ergibt sich damit als mögliches Störszenario, dass durch die Aussendung des LTE-Endgerätes im Bereich von ca. 850 MHz die SRD-Funkverbindungen bei 868 MHz insbesondere dann gestört werden, wenn die Antennen beider Funksysteme räumlich nahe zueinander angeordnet sind und folglich nur eine geringe zusätzliche Entkopplung der Systeme bieten. In der vorliegenden Arbeit wird das LTE-Störpotential auf SRD-Empfänger praxisnah untersucht.

Planungsunterstützung für Pankreasoperationen bei Hyperinsulinismus von Kindern

NASA Astrophysics Data System (ADS)

Dornheim, J.; Preim, B.; Preim, U.; Mohnike, K.; Blankenstein, O.; Füchtner, F.; Mohnike, W.; Empting, S.; Mohnike, K.

Auf Basis von sechs PET/CT-Datensätzen des Pankreas wird eine Computerunterstützung für die Teilresektion der Bauchspeicheldr üse (Pankreas) bei fokalem Hyperinsulinismus von Kindern entwickelt. Ziel ist es, die Lokalisation des krankhaften Fokus im Pankreasgewebe präoperativ dreidimensional zu visualisieren, um so die Sicherheit des Eingriffs zu erhöhen. Die relevanten anatomischen Strukturen werden im CT segmentiert und anschließend dreidimensional visualisiert. Der im PET erkennbare Fokus wird in diese anatomische 3D-Visualisierung eingeblendet. Es zeigt sich eine klare Erkennbarkeit des Fokus in allen sechs Fällen.

Visualisierung analoger Schaltungen durch 3-D Animation von transienten SPICE-Simulationen

NASA Astrophysics Data System (ADS)

Becker, J.; Manoli, Y.

2007-06-01

Für das Zeichnen analoger Schaltpläne wird oft versucht, die Potentialverteilung in der entsprechenden Schaltung auszunutzen, um eine Platzierung der Bauteile nach abfallendem Potential vorzunehmen. Mit Hilfe von Computerunterstützung gelingt es, eine verallgemeinerte dreidimensionale Platzierungsstrategie anzuwenden, die allein auf Grund der Potentialwerte einer Schaltung die automatische Generierung einer technisch exakten Potentialdarstellung erlaubt. Somit ist es möglich, die Ergebnisse von transienten SPICE-Simulationen in jedem Zeitschritt darzustellen und eine Animation des zeitlichen Verhaltens zu erzeugen. Die Umsetzung dieser Methode zur Einbettung in eine webbasierte Lern - und Arbeitsplattform wird im Folgenden erläutert.

In memory of Eugene (Jenő) von Gothard: a pioneering nineteenth century Hungarian astrophysicist

NASA Astrophysics Data System (ADS)

Vincze, Ildikő J.; Jankovics, István

2012-07-01

Eugene von Gothard was a Hungarian engineer/scientist, instrument-maker and astrophysicist who founded the Herény Astrophysical Observatory in 1881 and carried out pioneering work in astronomical photography and spectroscopy. In this paper we provide biographical material about von Gothard and describe his observatory, before discussing his astronomical observations and the contribution that hemade to the early development of astrophysics.

Dr. Wernher Von Braun

NASA Technical Reports Server (NTRS)

1999-01-01

Dr. Thomas Paine, Deputy Administrator of the National Aeronautics and Space Administration, examines an ordinary man's shoe outfitted for use in the Saturn I workshop. Pictured from the left in the Saturn I workshop mockup are William Brooksbank, propulsion and vehicle engineering laboratory; Dr. Paine; Dr. Wernher Von Braun, Marshall Center director; Colonel Clare F. Farley, Executive Officer in the Office Of The Administrator; and Charles J. Donlan, Deputy Associate Administrator for Manned Space Flight, Technical. the shoe Dr. Paine is holding has a unique fastener built into the sole to allow an astronaut to move about on the workshop floor and to remain in one position if he desires.

Von Braun Rocket Team at Fort Bliss, Texas

NASA Technical Reports Server (NTRS)

1940-01-01

The German Rocket Team, also known as the Von Braun Rocket Team, poses for a group photograph at Fort Bliss, Texas. After World War II ended in 1945, Dr. Wernher von Braun led some 120 of his Peenemuende Colleagues, who developed the V-2 rocket for the German military during the War, to the United Sttes under a contract to the U.S. Army Corps as part of Operation Paperclip. During the following five years the team worked on high altitude firings of the captured V-2 rockets at the White Sands Missile Range in New Mexico, and a guided missile development unit at Fort Bliss, Texas. In April 1950, the group was transferred to the Army Ballistic Missile Agency (ABMA) at Redstone Arsenal in Huntsville, Alabama, and continued to work on the development of the guided missiles for the U.S. Army until transferring to a newly established field center of the National Aeronautic and Space Administration (NASA), George C. Marshall Space Flight Center (MSFC).

Wernher von Braun

NASA Image and Video Library

2004-04-15

A pioneer of America's space program, Dr. von Braun stands by the five F-1 engines of the Saturn V launch vehicle. This Saturn V vehicle is an actual test vehicle which has been displayed at the U.S. Space Rocket Center in Huntsville, Alabama. Designed and developed by Rocketdyne under the direction of the Marshall Space Flight Center, a cluster of five F-1 engines was mounted on the Saturn V S-IC (first) stage. The engines measured 19-feet tall by 12.5-feet at the nozzle exit and burned 15 tons of liquid oxygen and kerosene each second to produce 7,500,000 pounds of thrust. The S-IC stage is the first stage, or booster, of a 364-foot long rocket that ultimately took astronauts to the Moon.

Sir Peter Medawar: science, creativity and the popularization of Karl Popper

PubMed Central

Calver, Neil

2013-01-01

Sir Peter Medawar was respected by scientists and literati alike. It was perhaps not surprising, then, that he would choose to involve himself in the ‘two cultures’ debate of 1959 and beyond. The focus of his intervention was the philosophy of Sir Karl Popper. However, Medawar's Popper was not the guru of falsification familiar from philosophy textbooks. Medawar's distinctive interpretation of Popper treated him instead as the source of insights into the role of creativity and imagination in scientific inquiry. This paper traces the context for Medawar's adoption of Popperian philosophy, together with its application before the debate. It then examines, within the context of the debate itself, the way in which Medawar attempted to reconcile scientific inquiry with literary practice. Medawar became increasingly convinced that not only was induction epistemologically unsound, but it was also damaging to the public role of the scientist. His construction of Popperianism would, he envisaged, provide a worthy alternative for scientists’ self-image.

The natural history of occult or angiodysplastic gastrointestinal bleeding in von Willebrand disease.

PubMed

Makris, M; Federici, A B; Mannucci, P M; Bolton-Maggs, P H B; Yee, T T; Abshire, T; Berntorp, E

2015-05-01

Recurrent gastrointestinal bleeding is one of the most challenging complications encountered in the management of patients with von Willebrand disease (VWD). The commonest cause is angiodysplasia, but often no cause is identified due to the difficulty in making the diagnosis. The optimal treatment to prevent recurrences remains unknown. We performed a retrospective study of VWD patients with occult or angiodysplastic bleeding within the setting of the von Willebrand Disease Prophylaxis Network (VWD PN) to describe diagnostic and treatment strategies. Centres participating in the VWD PN recruited subjects under their care with a history of congenital VWD and gastrointestinal (GI) bleeding due to angiodysplasia, or cases in which the cause was not identified despite investigation. Patients with acquired von Willebrand syndrome or those for whom the GI bleeding was due to another cause were excluded. Forty-eight patients from 18 centres in 10 countries were recruited. Seven individuals had a family history of GI bleeding and all VWD types except 2N were represented. Angiodysplasia was confirmed in 38%, with video capsule endoscopy and GI tract endoscopies being the most common methods of making the diagnosis. Recurrent GI bleeding in VWD is associated with significant morbidity and required hospital admission on up to 30 occasions. Patients were treated with multiple pharmacological agents with prophylactic von Willebrand factor concentrate being the most efficient in preventing recurrence of the GI bleeding. The diagnosis and treatment of recurrent GI bleeding in congenital VWD remains challenging and is associated with significant morbidity. Prophylactic treatment with von Willebrand factor concentrate was the most effective method of preventing recurrent bleeding but its efficacy remains to be confirmed in a prospective study. © 2014 John Wiley & Sons Ltd.

Johann Bernhard Aloys von Gudden and the Mad King of Bavaria

PubMed Central

Bhattacharyya, Kalyan B.

2017-01-01

Bernhard von Gudden was a psychiatrist in Prussia and he was summoned in March 1886 to examine King Ludwig II for his apparently insane activities like, profligate spending and erratic behaviour. A team of four estimable psychiatrists pronounced that he was not capable ruling. Consequently, he was dethroned and kept in a castle under supervision of von Gudden. Gudden championed the idea of 'no restraint' and advocated free movement of insane persons and one evening in June, he accompanied the King during an evening stroll to a lake. A few hours later, the corpus of both of them were recovered under mysterious circumstances. Autopsy suggested that the King was drowned but no post-mortem examination was performed on von Gudden. There are plenty of controversies regarding their death like, murder, accidental death or even natural death from cardiac arrest following immersion in cold water, but no incontrovertible conclusion could be arrived at, even after scrupulous analysis by historians and even the diagnosis of insanity of the King has been doubted. Some even suggested that the opinion of psychiatrists were sought as a pretense in order to depose the King. PMID:29184335

Director von Braun Presents General Medaris With Golf Bag

NASA Technical Reports Server (NTRS)

1959-01-01

Marshall Space Flight Center Director Wernher von Braun presents General J.B. Medaris with a new golf bag. General Medaris, (left) was a Commander of the Army Ballistic Missile Agency (ABMA) in Redstone Arsenal, Alabama during 1955 to 1958.

Alexander von Humboldt and the Origins of Landscape Archaeology.

ERIC Educational Resources Information Center

Mathewson, Kent

1986-01-01

Reviews the life, theories, and influence of Alexander von Humboldt, the early nineteenth century founder of modern geography. Maintains that Humboldt's novel approaches to the study of landscape antiquities have value for contemporary students in cultural and historical geography. (JDH)

Theory to Strategy: War Insight for the Strategic Soldier

DTIC Science & Technology

2008-05-22

Library Typography , New York, 1993, 162. 3 Additionally, these models may provide insights as to what an adversary may do depending on the nature of...11. 7 Carl Von Clausewitz, On War (edited and translated by Michael Howard and Peter Paret), Everyman’s Library Typography , New York, 1993, 73...Paret), Everyman’s Library Typography , New York, 1993, 88. 8 common enemy. Minimizing the amount of allies an adversary has may also limit its

Clausewitz on Kosovo

DTIC Science & Technology

2000-12-16

George Bush issued his “Christmas warning” to Miloševic.34 When the violence escalated, Washington dispatched Ambassador Richard Holbrooke to negotiate a...concede this is impossible. Richard Holbrooke said, “diplomacy, like jazz, is the constant improvisation on a theme.”102 Helmuth von Moltke wrote...Peter D. Feaver and Richard H. Kohn, “The Gap: Soldiers, Civilians, and their Mutual Misunderstanding,” The National Interest no. 61 (fall 2000): 29-37

Facies identification based on conventional core-log integration: Middle Ordovician St. Peter sandstone, Michigan basin

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wieczorek, L.M.; Barnes, D.A.

1989-08-01

Lithofacies comprising the massive sand in the Michigan basin are very similar to the lithofacies of the St. Peter Sandstone in parts of the adjacent Midwestern basin and arches region. Lithostratigraphic and biostratigraphic correlations justify application of the name St. Peter Sandstone to the gas-productive massive sand in the Michigan basin. Four lithofacies have been determined by core-log integration. The two lowermost lithofacies (1 and 2) were deposited in marginal-marine peritidal shoreface to sand-flat environments. Lithofacies 1A comprises cross-bedded, quartz-cemented quartzarenites. Lithofacies 1B comprises dolomitic, cross-bedded, subfeldspathic arenites. Lithofacies 1A is recognized in logs by low gamma-ray response (less thanmore » 20-25 API units) and photoelectric effect (Pe) of 1.8. Lithofacies 1B log characteristics include low gamma ray response (15-30 API units) and Pe of 2-2.5. Lithofacies 2 log signatures include moderate to high gamma-ray (30-120 API units) and Pe values that range from 2.5-3.5. The uppermost two lithofacies (3 and 4) were deposited in storm-dominated lower shoreface, to offshore, to distal marine shelf environments. Lithofacies 3 consists of burrowed, massive, wavy to planar stratified quartzarenites to subfeldspathic arenites. Log signature is generally low gamma-ray response (15-30 API units) and Pe that ranges from 1.8 to 2.5. Lithofacies 4 consists of massive, burrowed and bioturbated, dominantly authigenic clay and dolomite-cemented subfeldspathic arenite. Lithofacies 4 log response is moderate to high gamma-ray response (30-105 API units) and Pe ranging from 2.25 to 3.5.« less

The search for asbestos within the Peter Mitchell Taconite iron ore mine, near Babbitt, Minnesota.

PubMed

Ross, Malcolm; Nolan, Robert P; Nord, Gordon L

2008-10-01

Asbestos crystallizes within rock formations undergoing intense deformation characterized by folding, faulting, shearing, and dilation. Some of these conditions have prevailed during formation of the taconite iron ore deposits in the eastern Mesabi Iron Range of Minnesota. This range includes the Peter Mitchell Taconite Mine at Babbitt, Minnesota. The mine pit is over 8 miles long, up to 1 mile wide. Fifty three samples were collected from 30 sites within areas of the pit where faulting, shearing and folding occur and where fibrous minerals might occur. Eight samples from seven collecting sites contain significant amounts of ferroactinolite amphibole that is partially to completely altered to fibrous ferroactinolite. Two samples from two other sites contain ferroactinolite degraded to ropy masses of fibers consisting mostly of ferrian sepiolite as defined by X-ray diffraction and TEM and SEM X-ray spectral analysis. Samples from five other sites contain unaltered amphiboles, however some of these samples also contain a very small number of fiber bundles composed of mixtures of grunerite, ferroactinolite, and ferrian sepiolite. It is proposed that the alteration of the amphiboles was caused by reaction with water-rich acidic fluids that moved through the mine faults and shear zones. The fibrous amphiboles and ferrian sepiolite collected at the Peter Mitchell Mine composes a tiny fraction of one percent of the total rock mass of this taconite deposit; an even a smaller amount of these mineral fragments enter the ambient air during mining and milling. These fibrous minerals thus do not present a significant health hazard to the miners nor to those non-occupationally exposed. No asbestos of any type was found in the mine pit.

Wernher von Braun

NASA Image and Video Library

1971-07-26

During the Apollo 15 launch activities in the launch control center's firing room 1 at Kennedy Space Center, Dr. Wernher von Braun, NASA's Deputy Associate Administrator for planning, takes a closer look at the launch pad through binoculars. The fifth manned lunar landing mission, Apollo 15 (SA-510), carrying a crew of three astronauts: Mission commander David R. Scott, Lunar Module pilot James B. Irwin, and Command Module pilot Alfred M. Worden Jr., lifted off on July 26, 1971. Astronauts Scott and Irwin were the first to use a wheeled surface vehicle, the Lunar Roving Vehicle, or the Rover, which was designed and developed by the Marshall Space Flight Center, and built by the Boeing Company. Astronauts spent 13 days, nearly 67 hours, on the Moon's surface to inspect a wide variety of its geological features.

GPU-basierte Smart Visibility Techniken für die Planung von Tumor-Operationen

NASA Astrophysics Data System (ADS)

Tietjen, Christian; Kubisch, Christoph; Hiller, Stefan; Preim, Bernhard

Bei der Planung von Tumoroperationen ist die Einschätzung von Abständen und Infiltrationen zu vitalen Strukturen wichtig. Im Bereich der medizinischen Visualisierung wurden hierfür bereits zahlreiche Techniken entwickelt, die unter dem Begriff Smart Visibility zusammengefasst werden. Zu diesen zählen Ghost Views und Section Views. In diesem Beitrag wird eine GPU-basierte Realisierung dieser Techniken für polygonale Daten vorgestellt. Die Parametrisierung der Techniken erfolgt automatisch, um einen klinischen Einsatz ermöglichen zu können.

The Influence of Field Marshal Colmar Von Der Goltz on Ottoman Military Effectiveness in Mesopotamia: December 1915 to April 1916

DTIC Science & Technology

2012-02-23

SUBTITLE The Influence of Field Marshal Colmar Von Der Goltz on Ottoman Military Effectiveness in Mesopotamia: December 1915 to April 1916 5a...SUPPLEMENTARY NOTES N/A 14. ABSTRACT This paper discusses the contributions made by Field Marshal Colmar von der Goltz on the development of Ottoman...Kut. 15. SUBJECT TERMS Colmar von der Goltz ; Military advisor; Mesopotamian Campaign; Ottoman; Ottoman military effectiveness; British; Kut; World

The Learning Curve in neurofeedback of Peter Van Deusen: A review article

PubMed Central

Ribas, Valdenilson Ribeiro; Ribas, Renata de Melo Guerra; Martins, Hugo André de Lima

2016-01-01

ABSTRACT The Learning Curve (TLC) in neurofeedback concept emerged after Peter Van Deusen compiled the results of articles on the expected electrical activity of the brain. This concept was subsequently tested on patients at four clinics in Atlanta between 1994 and 2001. The aim of this paper was to report the historical aspects of TLC. Articles published on the electronic databases MEDLINE/PubMed and Web of Science were reviewed. During patient evaluation, TLC investigates categories called disconnected, hot temporal lobes, reversal of alpha and beta waves, blocking, locking, and filtering or processing. This enables neuroscientists to use their training designs and, by means of behavioral psychology, to work on neuroregulation, as self-regulation for patients. TLC shows the relationships between electrical, mental and behavioral activity in patients. It also identifies details of patterns that can assist physicians in their choice of treatment. PMID:29213440

Laboratory Testing for von Willebrand Disease: The Past, Present, and Future State of Play for von Willebrand Factor Assays that Measure Platelet Binding Activity, with or without Ristocetin.

PubMed

Just, Sarah

2017-02-01

von Willebrand disease (VWD) was first described nearly a century ago in 1924 by Erik Adolf von Willebrand. Diagnostic testing at the time was very limited and it was not until the mid to late 1900s that more tests became available to assist with the diagnosis and classification of VWD. Two of these tests are based on ristocetin, one being ristocetin-induced platelet aggregation (RIPA) and the other the von Willebrand factor (VWF) ristocetin cofactor assay (VWF:RCo). The VWF:RCo assay provides functional assessment of in vitro VWF binding to the platelet glycoprotein (Gp) complex, GPIb-IX-V. Despite some advancements and newer technologies utilizing the principles of the original VWF:RCo assay, the original assay is still referred to as the gold standard for measurement of VWF activity. This article will review the history of VWD diagnostic assays, including RIPA and VWF:RCo over the past 40 years, as well as the newer assays that measure platelet binding with or without ristocetin, and which have been developed with the aim to potentially replace platelet-based ristocetin-dependent assays. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Potential supplementary utility of combined PFA-100 and functional von Willebrand factor testing for the laboratory assessment of desmopressin and factor concentrate therapy in von Willebrand disease.

PubMed

Favaloro, Emmanuel J; Thom, Jim; Patterson, David; Just, Sarah; Baccala, Maria; Dixon, Tracy; Meiring, Muriel; Koutts, Jerry; Rowell, John; Baker, Ross

2009-09-01

We performed a retrospective audit of cross-laboratory testing of desmopressin and factor concentrate therapy to assess the potential utility of supplementary testing using the PFA-100 with functional von Willebrand factor (VWF) activity testing. Data were evaluated for a large number of patients with von Willebrand disease of type 1, type 2A or type 2M, as well as a comparative subset of individuals with haemophilia or carriers of haemophilia. Laboratory testing comprised pre and postdesmopressin, or pre and postconcentrate, evaluation of factor VIII, VWF antigen (VWF:Ag) and VWF ristocetin cofactor activity as traditionally performed, supplemented with collagen-binding (VWF:CB) testing and PFA-100 closure times. In brief, both therapies tended to normalize VWF test parameters and closure times in individuals with type 1 von Willebrand disease, with the level of correction in closure times related to the level of normalization of VWF, particularly the VWF:CB. However, although occasional correction of closure times was observed in patients with type 2A or type 2M von Willebrand disease, these did not in general normalize PFA-100 closure times either with desmopressin or factor concentrate therapy. In these patients, improvement in closure times was more likely in those in whom VWF:CB values normalized or when VWF:CB/VWF:Ag ratios normalized. This study confirms that there is a strong relationship between the presenting levels of plasma VWF and PFA-100 closure times, and that the supplementary combination of PFA-100 and VWF:CB testing might provide added clinical utility to current broadly applied testing strategies limited primarily to VWF:Ag, VWF ristocetin cofactor and factor VIII:coagulant. Future prospective investigations are warranted to validate these relationships and to investigate their therapeutic implications.

A comparative study of results of the von Langenbeck and the V-Y pushback palatoplasties.

PubMed

Krause, C J; Tharp, R F; Morris, H L

1976-01-01

The incidence of velopharyngeal competence noted in 267 cleft palate patients following palatoplsty has been reviewed. Comparisons have been drawn with regard to the cleft type and the surgical technique performed. Since there were relatively small numbers of subjects in some categories, differences in age at last examination between the von Langenbeck and V-Y palatoplasty groups, some patients were very young at time of evaluation, and a number of different surgeons at different levels of training and experience performed the surgery, the differences in velopharyngeal competence found should be viewed as trends and this report as preliminary. In general, there was a trend toward smaller percentages of patients attaining acceptable velopharyngeal competence as the severity of the cleft increased. Of those with clefts of the soft palate only 86 per cent achieved competence. Among those patients with clefts of the palate only, 67 per cent achieved competence, whereas only 57 per cent of those with clefts of the lip and palate were able to do so. When comparing all cleft types, the V-Y palatoplasty resulted in a significantly higher percentage of velopharyngeal competence (74 per cent) than did the von Langenbeck method (56 per cent), although the data for the V-Y group are probably less reliable than those for the von Langenbeck group. In the soft palate only category, the results were slightly better with the von Langenbeck technique, though not significantly so. In all other cleft types, the results with the V-Y method were better than those with the von Langenbeck.

Intense Undular Bores on the Autumn Pycnocline of Shelf Waters of the Peter the Great Bay (Sea of Japan)

NASA Astrophysics Data System (ADS)

Dolgikh, G. I.; Novotryasov, V. V.; Yaroshchuk, I. O.; Permyakov, M. S.

2018-03-01

The results of field observations of an internal undular bore that were performed in a coastal zone of constant depth in the Sea of Japan are presented. A hydrodynamic model of undular bores is discussed according to which the recorded disturbances of the water medium are an experimental prototype of strongly nonlinear (intense) internal undular bores on the pycnocline of shelf waters of Peter the Great Bay with an intensity close to the limit.

Wilhelm von Humboldt's Idea of "Bildung" and Education.

ERIC Educational Resources Information Center

Stubbs, Elsina

The importance of Wilhelm von Humboldt's work in educational philosophy is little known outside of Germany and even there he is more often criticized than praised. This is unfortunate because his contributions to education and other areas had an important impact on other philosophers of his period and are well worth considering today. In his main…

[Hildegards von Bingen 'Liber simplicis medicinae' in the Mainz 'Garden of Health'].

PubMed

Riethe, Peter

2005-01-01

The "Garden of Health" (Gart der Gesundheit) is the first illustrated book of herbs in German language. Its author, Johann Wonnecke from Kaub on the Rhine, was born in 1430 and worked as a city doctor in Frankfurt/Main until his death in 1503 or 1504. In his book, he refers to "proven Greek, Latin and Arabic masters of medicine" (bewerte meister in der artzeney), whose writings he was instructed to collect by Bernard von Breidenbach in 1480. Wonnecke carried out he task in a special way, deceiving five generations of historians of science, who proceeded from the false assumption, that the Gart der Gesundheit was compiled and translated from Latin sources. Wonnecke established the desired authors skilfully in his report, but under a more detailed investigation they reveal themselves as not taken from Latin sources but copied off from native language scriptures, e.g. Alterer deutscher Macer and Buch der Natur by Konrad von Megenberg. To these hitherto known sources used by him now the Speyrer Kräuterbuch is added, which supplied the medical knowledge of Hildegard von Bingen to the "Gart".

Shallow water sea slugs (Gastropoda: Heterobranchia) from the northwestern coast of the Sea of Japan, north of Peter the Great Bay, Russia

PubMed Central

2016-01-01

The coast of northern Primorye region, north of Peter the Great Bay has been sparsely studied in regards to its molluscan fauna, with just a few works reviewing the distribution of local mollusks. This work presents a survey of the shallow water heterobranch sea slugs currently occurring around Kievka Bay to Oprichnik Bay, Russia. Thirty-nine species of sea slugs were found in this study and the new species Cadlina olgae sp. nov., described herein. Most (24) of the species occurring in the area have widespread ranges in the northern Pacific Ocean. The eight species are endemic for the Sea of Japan and adjacent part of the Sea of Okhotsk. Seven other occur also in northern Atlantic and Arctic waters. Thirteen found species are not known from Peter the Great Bay but known from adjacent northern Pacific waters. The finding of a previously undescribed species emphasizes the need of further surveys, particularly in subtidal and deeper waters, in order to improve the knowledge on this neglected fauna in Primorye. PMID:27957399

"'And They Lived Happily Ever After": The Fairy Tale of Radical Constructivism and Von Glasersfeld's Ethical Disengagement

ERIC Educational Resources Information Center

d'Agnese, Vasco

2015-01-01

Is von Glasersfeld's constructivism actually radical? In this article, I respond to this question by analyzing von Glasersfeld's main works. I argue that the essential theoretical move of radical constructivism--namely the assertion that reality is the construction of a human mind that only responds to the subjective perception of "what…

Report on von Willebrand Disease in Malaysia

PubMed Central

Periayah, Mercy Halleluyah; Halim, Ahmad Sukari; Saad, Arman Zaharil Mat; Yaacob, Nik Soriani; Karim, Faraizah Abdul

2016-01-01

BACKGROUND: Von Willebrand disease (vWD) is an inherited hemostatic disorder that affects the hemostasis pathway. The worldwide prevalence of vWD is estimated to be 1% of the general population but only 0.002% in Malaysia. AIM: Our present paper has been written to disclose the statistical counts on the number of vWD cases reported from 2011 to 2013. MATERIAL AND METHODS: This article is based on sociodemographic data, diagnoses and laboratory findings of vWD in Malaysia. A total of 92 patients were reported to have vWD in Malaysia from 2011 to 2013. RESULTS: Sociodemographic-analysis revealed that 60% were females, 63% were of the Malay ethnicity, 41.3% were in the 19-44 year old age group and 15.2% were from Sabah, with the East region having the highest registered number of vWD cases. In Malaysia, most patients are predominately affected by vWD type 1 (77.2%). Factor 8, von Willebrand factor: Antigen and vWF: Collagen-Binding was the strongest determinants in the laboratory profiles of vWD. CONCLUSION: This report has been done with great interest to provide an immense contribution from Malaysia, by revealing the statistical counts on vWD from 2011-2013. PMID:27275342

Gesellschaft, Lebensgemeinschaft, Ökosystem - Über die Kongruenz von politischen und ökologischen Theorien der Entwicklung

NASA Astrophysics Data System (ADS)

Voigt, Annette

Im Jahr 1859 veröffentlichte Charles Darwin "On the Origin of Species“. Seine Evolutionstheorie ist das wohl spektakulärste Beispiel einer naturwissenschaftlichen Theorie großer gesellschaftlicher Relevanz. Ihre verschiedenen Facetten wurden in der Öffentlichkeit kontrovers diskutiert, unter anderem auch ihre Anwendung zur Erklärung von Zuständen und Prozessen menschlicher Gesellschaften. Zum Teil wurde die Seiensweise der Natur - scheinbar unabhängig von gesellschaftlichen Interessen - für die Erklärung und Legitimation gesellschaftlicher Zustände oder die Legitimation von politischen Ideologien herangezogen (Sozialdarwinismus). Denn Gesellschaft funktioniere ja so, wie Darwin die Natur erklärt habe: es herrsche z. B. Konkurrenzkampf, Auslese und Arbeitsteilung, Erfolg hätten diejenigen, die sich an die Bedingungen am Besten anpassten.

Ernst von Glasersfeld's Radical Constructivism and Truth as Disclosure

ERIC Educational Resources Information Center

Joldersma, Clarence W.

2011-01-01

In this essay Clarence Joldersma explores radical constructivism through the work of its most well-known advocate, Ernst von Glasersfeld, who combines a sophisticated philosophical discussion of knowledge and truth with educational practices. Joldersma uses Joseph Rouse's work in philosophy of science to criticize the antirealism inherent in…

Spin torque oscillator neuroanalog of von Neumann's microwave computer.

PubMed

Hoppensteadt, Frank

2015-10-01

Frequency and phase of neural activity play important roles in the behaving brain. The emerging understanding of these roles has been informed by the design of analog devices that have been important to neuroscience, among them the neuroanalog computer developed by O. Schmitt and A. Hodgkin in the 1930s. Later J. von Neumann, in a search for high performance computing using microwaves, invented a logic machine based on crystal diodes that can perform logic functions including binary arithmetic. Described here is an embodiment of his machine using nano-magnetics. Electrical currents through point contacts on a ferromagnetic thin film can create oscillations in the magnetization of the film. Under natural conditions these properties of a ferromagnetic thin film may be described by a nonlinear Schrödinger equation for the film's magnetization. Radiating solutions of this system are referred to as spin waves, and communication within the film may be by spin waves or by directed graphs of electrical connections. It is shown here how to formulate a STO logic machine, and by computer simulation how this machine can perform several computations simultaneously using multiplexing of inputs, that this system can evaluate iterated logic functions, and that spin waves may communicate frequency, phase and binary information. Neural tissue and the Schmitt-Hodgkin, von Neumann and STO devices share a common bifurcation structure, although these systems operate on vastly different space and time scales; namely, all may exhibit Andronov-Hopf bifurcations. This suggests that neural circuits may be capable of the computational functionality as described by von Neumann. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Peter Holland: a pioneer of occupational medicine.

PubMed Central

Murray, R

1992-01-01

The earliest recorded occupational health service in this country was that established in a cotton spinning factory at Quarry Bank Mill in Cheshire. The mill was built in 1784 by Samuel Greg and his partners. They employed local labour and also some parish apprentices. Happily, Samuel Greg was a good christian and, having created a modern factory and a model village with a church and a school, he was equally concerned for the physical welfare of his employees. Accordingly, he appointed a doctor to make pre-employment examinations of the apprentices and to visit regularly to deal with the health problems of a community of some 400 people. The man he chose was Peter Holland of Sandlebridge, who had served his medical apprenticeship under Dr Charles White of Manchester. The first record of the employment of a doctor was in 1796, but from 1804 to 1845 (doubtless in response to the early factory legislation) each visit of the doctor was entered in a day book with either an indication of fitness to work or details of the treatment required. The complete record consists of two hardback foolscap notebooks that provide a fascinating insight into the medical practice of the times when the industrial revolution was just getting under way. One of the more interesting features is the preservation of medical secrecy. Dr Holland made his comments on the case in shorthand and his instructions in longhand. By a fortunate coincidence the key to the shorthand was discovered and this has now been largely transcribed. Although much of the content of the diaries is the day by day practice of medicine at the time, there are many illuminating glimpses of the early practice of occupational medicine. Images PMID:1606023

Recombinant von Willebrand factor: preclinical development.

PubMed

Plaimauer, B; Schlokat, U; Turecek, P L; Mitterer, A; Mundt, W; Auer, W; Pichler, L; Gritsch, H; Schwarz, H P

2001-08-01

Von Willebrand factor (vWF) is a multimeric glycoprotein (GP) that attracts platelets to the site of vascular injury, mediates platelet-platelet interaction, and stabilizes factor VIII (FVIII) in the circulation. Quantitative and qualitative defects of vWF result in von Willebrand disease (vWD), manifested by modest to severe bleeding episodes. Substitution therapy, with plasma-derived FVIII/vWF complex concentrates, is used for patients suffering the more severe forms of vWD. Efficacy of these preparations is often unsatisfactory because inadvertent proteolytic degradation during the manufacturing process causes them to lack the hemostatically most active high-molecular-weight multimers. In contrast, recombinant vWF (r-vWF), which is constitutively expressed at high yields in Chinese hamster ovary (CHO) cells and secreted into the conditioned medium under perfusion fermentation in "protein-free" medium, has high-molecular-weight multimers of extraordinary structural integrity. Functional analysis has shown that r-vWF promotes ristocetin cofactor-mediated platelet aggregation, collagen interaction and FVIII binding, and platelet-collagen adhesion under shear stress. Infusing vWF-deficient animals with r-vWF corrected vWF concentration and reduced blood loss, subsequently stabilizing endogenous FVIII associated with the reduction of bleeding time. Compared with plasma-derived vWF preparations, r-vWF was found to have a prolonged half-life, further enhancing the potential value of r-vWF as a therapeutic agent for treating patients suffering from vWD.

[Comment on “Review papers: Proceedings vs. journals” by S. Peter Gary] On the venue of review papers

NASA Astrophysics Data System (ADS)

Eviatar, Aharon

S. Peter Gary has called our attention (“Review Papers: Proceedings vs. Journals,” Eos, March 3, 1987, p. 125) to the lesson of the noted philosopher of science, S.W.H. Cowley, to wit: “Proceedings are simply not accessible to the same degree as journals.” From this, Gary concludes that it would be much more desirable if space physics review articles were published in refereed journals rather than in conference proceedings. I should like to comment a bit on this, if I may.

Dr. Wernher Von Braun near the mobile launcher.

NASA Technical Reports Server (NTRS)

1999-01-01

Dr. George Mueller, NASA associate administrator for manned space flight, and Dr. Wernher Von Braun (right), director of the Marshall Space Flight Center, are seen near the mobile launcher carrying a 363 foot tall Saturn V space launch vehicle as the rocket is rolled from the vehicle assembly building at KSC for its three mile trip to the launch pad.

Dr. von Braun With a Model of a Launch Vehicle

NASA Technical Reports Server (NTRS)

1950-01-01

Dr. von Braun stands beside a model of the upper stage (Earth-returnable stage) of the three-stage launch vehicle built for the series of the motion picture productions of space flight produced by Walt Disney in the mid-1950's.

Remembrances of Ulf Svante von Euler.

PubMed

Igić, Rajko

2018-05-21

I first met Ulf Svante von Euler when he came to Belgrade, in 1968, to attend an international symposium on the occasion of the 50 th anniversary of the Medical Faculty. I was at that time a graduate student at the Medical Faculty in Sarajevo, and a new researcher. I had finished medical school in Belgrade and had worked for two years as a physician in the northern part of Serbia. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

Robuste Verzweigungserkennung von Gefäßen in CTA-Datensätzen zur modellbasierten Extraktion der Centerline

NASA Astrophysics Data System (ADS)

Beck, Thomas; Fritz, Dominik; Biermann, Christina; Dillmann, Rüdiger

Bei der Befundung und Visualisierung von Blutgefäßen ist deren Centerline von zentraler Bedeutung. Die Unterscheidung zwischen unverzweigten Abschnitten des Gefäßes und Verzweigungsbereichen ermöglicht den Einsatz spezialisierter und sehr effizienter Algorithmen zur modellbasierten Extraktion der Centerline. In diesem Artikel wird ein robustes Verfahren zur Verzweigungserkennung vorgestellt. Das Verfahren beruht auf einem Front-Propagation-Ansatz mit dynamisch angepassten Schwellwerten und einer anschließenden Clusteranalyse. Die vorgestellte Methode zur Verzweigungserkennung wurde als Komponente einer Architektur zur Extraktion der Centerline auf handannotierten Datensätzen getestet. Erste Ergebnisse sind sehr vielversprechend und ermöglichen auch bei pathologischen Gefäßen eine robuste Detektion von Gefäßverzweigungen.

Haemangioblastoma of a cervical sensory nerve root in Von Hippel-Lindau syndrome.

PubMed

McEvoy, A W; Benjamin, E; Powell, M P

2000-10-01

Spinal haemangioblastomas are rare, accounting for only about 7% of all central nervous system cases. The case of a 40-year-old woman with a haemangioblastoma arising solely from a cervical sensory nerve root is presented. At operation via a cervical laminectomy, it was possible to resect the tumour en masse with the sensory ramus, by extending the laminectomy through the exit foramen for C6. Haemangioblastomas are commonly intramedullary, and have only been reported in this location on one previous occasion. The patient has Von Hippel-Lindau syndrome and a history of multiple solid tumours. The possible role of the Von Hippel-Lindau tumour suppressor gene in the pathogenesis of these neoplasms is discussed.

Analyses and description of geochemical samples, Peters Mountain Wilderness Study Area, Giles County, Virginia

USGS Publications Warehouse

Rait, Norma; Lesure, Frank Gardner

1978-01-01

Semiquantitative emission spectrographic analyses for 64 elements on 43 stream sediment and 73 rock samples from Peters Mountain Wilderness Study area, Giles County, Virginia, are reported here in detail. Locations for all samples are in Universal Transverse Mercator (UTM) coordinates. Brie[ descriptions of rock samples are also included. Rocks analysed are mostly sandstone. Samples of hematitic sandstone of the Rose Hill Formation and limonite-cemented sandstone of the Rocky Gap Sandstone contain high values of iron; these rocks are submarginal iron resources. Some of the same iron-rich samples have a little more barium, copper, cobalt, lead, silver, and/or zinc then average sandstone, but they do not suggest the presence of economic deposits of these metals. No other obviously anomalous values related to mineralized rock are present in the data.

Peter Bourne's drug policy and the perils of a public health ethic, 1976-1978.

PubMed

Clark, Claire D; Dufton, Emily

2015-02-01

As President Jimmy Carter's advisor for health issues, Peter Bourne promoted a rational and comprehensive drug strategy that combined new supply-side efforts to prevent drug use with previously established demand-side addiction treatment programs. Using a public health ethic that allowed the impact of substances on overall population health to guide drug control, Bourne advocated for marijuana decriminalization as well as increased regulations for barbiturates. A hostile political climate, a series of rumors, and pressure from both drug legalizers and prohibitionists caused Bourne to resign in disgrace in 1978. We argue that Bourne's critics used his own public health framework to challenge him, describe the health critiques that contributed to Bourne's resignation, and present the story of his departure as a cautionary tale for today's drug policy reformers.

Versuche zur Gewinnung von katalytischen Antikörpern zur Hydrolyse von Arylcarbamaten und Arylharnstoffen. (English Title: Attempts to produce catalytic antibodies for hydrolysis of arylcarbamates and arylureas)

NASA Astrophysics Data System (ADS)

Werner, Deljana

2002-05-01

Im Rahmen dieser Arbeit gelang es, katalytische Antikörper zur Hydrolyse von Benzylphenylcarbamaten sowie zahlreiche monoklonale Antikörper gegen Haptene herzustellen. Es wurden verschiedene Hapten-Protein-Konjugate unter Verwendung unterschiedlicher Kopplungsmethoden hergestellt und charakterisiert. Zur Generierung der hydrolytisch aktiven Antikörper wurden Inzuchtmäuse mit KLH-Konjugaten von 4 Übergangszustandsanaloga (ÜZA) immunisiert. Mit Hilfe der Hybridomtechnik wurden verschiedene monoklonale Antikörper gegen diese ÜZA gewonnen. Dabei wurden sowohl verschiedene Immunisierungsschemata als auch verschiedene Inzuchtmausstämme und Fusionstechniken verwendet. Insgesamt wurden 32 monoklonale Antikörper gegen die verwendeten ÜZA selektiert. Diese Antikörper wurden in groen Mengen hergestellt und gereinigt. Zum Nachweis der Antikörper-vermittelten Katalyse wurden verschiedene Methoden entwickelt und eingesetzt, darunter immunologische Nachweismethoden mit Anti-Substrat- und Anti-Produkt-Antikörpern und eine photometrische Methode mit Dimethylaminozimtaldehyd. Der Nachweis der hydrolytischen Aktivität gelang mit Hilfe eines Enzymsensors, basierend auf immobilisierter Tyrosinase. Die Antikörper N1-BC1-D11, N1-FA7-C4, N1-FA7-D12 und R3-LG2-F9 hydrolysierten die Benzylphenylcarbamate POCc18, POCc19 und Substanz 27. Der Nachweis der hydrolytischen Aktivität dieser Antikörper gelang auch mit Hilfe der HPLC. Der katalytische Antikörper N1-BC1-D11 wurde kinetisch und thermodynamisch untersucht. Es wurde eine Michaelis-Menten-Kinetik mit Km von 210 µM, vmax von 3 mM/min und kcat von 222 min-1 beobachtet. Diese Werte korrelieren mit den Werten der wenigen bekannten Diphenylcarbamat-spaltenden Abzyme. Die Beschleunigungsrate des Antikörpers N1-BC1-D11 betrug 10. Das ÜZA Hei3 hemmte die hydrolytische Aktivität. Dies beweist, dass die Hydrolyse in der Antigenbindungsstelle stattfindet. Weiter wurde zwischen der Antikörperkonzentration und der

Study of dissolved oxygen content in the Eastern Bosporus Strait (Peter the Great Bay, Sea of Japan)

NASA Astrophysics Data System (ADS)

Grigoryeva, N. I.

2017-09-01

Seasonal changes in the dissolved oxygen (DO) content in water were analyzed based on long-term observations (2006-2013) in the Eastern Bosporus Strait (Peter the Great Bay, Sea of Japan). It was found that the monthly average DO concentrations at the bottom of the strait were significantly lower in summer than the average annual long-term data. The minimum DO contents were recorded during four months, from July to October. It was shown that the DO content in water depended on changes in current directions in the strait: lower DO contents resulted from hypoxic water inflow, mostly from Amur Bay.

The education of Ehrenfried Walther von Tschirnhaus (1651-1708).

PubMed

Adler, Jacob

2015-02-01

Ehrenfried Walther von Tschirnhaus, mathematician, inventor, and correspondent of Spinoza, is often thought to have studied medicine at Leiden, though documentation of this fact has been lacking. Tschirnhaus' medical education is here documented, along with the nature of his medical practice. © The Author(s) 2013 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

S2k-Leitlinie zum Gebrauch von Präparationen zur lokalen Anwendung auf der Haut (Topika).

PubMed

Wohlrab, Johannes; Staubach, Petra; Augustin, Matthias; Eisert, Lisa; Hünerbein, Andreas; Nast, Alexander; Reimann, Holger; Strömer, Klaus; Mahler, Vera

2018-03-01

Diese Leitlinie richtet sich an Assistenz- und Fachärzte der Dermatologie sowie an Kostenträger und politische Entscheidungsgremien. Die Leitlinie wurde im formellen Konsensusverfahren (S2k) von Dermatologen unter Einbindung von Apothekern erstellt. Die Leitlinie stellt allgemeine Aspekte der Pharmakokinetik sowie der regulatorischen Begrifflichkeiten dar. Es werden Empfehlungen zur Indikation von Magistralrezepturen sowie deren Qualitätssicherung gegeben. Die Bedeutung der galenischen Grundlagen und die Problematik bei einer Substitution gegeneinander verschiedener Grundlagen werden dargestellt. Die Leitlinie umfasst Kriterien zur Auswahl einer adäquaten Grundlage sowie spezifische Aspekte zur Therapieplanung. Die Leitlinie gibt Empfehlungen zum Management bei Unverträglichkeiten gegenüber Bestandteilen der Grundlagen oder Hilfsstoffe. © 2018 The Authors | Journal compilation © Blackwell Verlag GmbH, Berlin.

Superfluid high REynolds von Kármán experiment.

PubMed

Rousset, B; Bonnay, P; Diribarne, P; Girard, A; Poncet, J M; Herbert, E; Salort, J; Baudet, C; Castaing, B; Chevillard, L; Daviaud, F; Dubrulle, B; Gagne, Y; Gibert, M; Hébral, B; Lehner, Th; Roche, P-E; Saint-Michel, B; Bon Mardion, M

2014-10-01

The Superfluid High REynolds von Kármán experiment facility exploits the capacities of a high cooling power refrigerator (400 W at 1.8 K) for a large dimension von Kármán flow (inner diameter 0.78 m), which can work with gaseous or subcooled liquid (He-I or He-II) from room temperature down to 1.6 K. The flow is produced between two counter-rotating or co-rotating disks. The large size of the experiment allows exploration of ultra high Reynolds numbers based on Taylor microscale and rms velocity [S. B. Pope, Turbulent Flows (Cambridge University Press, 2000)] (Rλ > 10000) or resolution of the dissipative scale for lower Re. This article presents the design and first performance of this apparatus. Measurements carried out in the first runs of the facility address the global flow behavior: calorimetric measurement of the dissipation, torque and velocity measurements on the two turbines. Moreover first local measurements (micro-Pitot, hot wire,…) have been installed and are presented.

Superfluid high REynolds von Kármán experiment

NASA Astrophysics Data System (ADS)

Rousset, B.; Bonnay, P.; Diribarne, P.; Girard, A.; Poncet, J. M.; Herbert, E.; Salort, J.; Baudet, C.; Castaing, B.; Chevillard, L.; Daviaud, F.; Dubrulle, B.; Gagne, Y.; Gibert, M.; Hébral, B.; Lehner, Th.; Roche, P.-E.; Saint-Michel, B.; Bon Mardion, M.

2014-10-01

The Superfluid High REynolds von Kármán experiment facility exploits the capacities of a high cooling power refrigerator (400 W at 1.8 K) for a large dimension von Kármán flow (inner diameter 0.78 m), which can work with gaseous or subcooled liquid (He-I or He-II) from room temperature down to 1.6 K. The flow is produced between two counter-rotating or co-rotating disks. The large size of the experiment allows exploration of ultra high Reynolds numbers based on Taylor microscale and rms velocity [S. B. Pope, Turbulent Flows (Cambridge University Press, 2000)] (Rλ > 10000) or resolution of the dissipative scale for lower Re. This article presents the design and first performance of this apparatus. Measurements carried out in the first runs of the facility address the global flow behavior: calorimetric measurement of the dissipation, torque and velocity measurements on the two turbines. Moreover first local measurements (micro-Pitot, hot wire,…) have been installed and are presented.

Kinematic α tensors and dynamo mechanisms in a von Kármán swirling flow.

PubMed

Ravelet, F; Dubrulle, B; Daviaud, F; Ratié, P-A

2012-07-13

We provide experimental and numerical evidence of in-blades vortices in the von Kármán swirling flow. We estimate the associated kinematic α-effect tensor and show that it is compatible with recent models of the von Kármán sodium (VKS) dynamo. We further show that depending on the relative frequency of the two impellers, the dominant dynamo mechanism may switch from α2 to α - Ω dynamo. We discuss some implications of these results for VKS experiments.

Clinical and laboratory diagnosis of von Willebrand disease: A synopsis of the 2008 NHLBI/NIH guidelines

PubMed Central

Nichols, William L.; Rick, Margaret E.; Ortel, Thomas L.; Montgomery, Robert R.; Sadler, J. Evan; Yawn, Barbara P.; James, Andra H.; Hultin, Mae B.; Manco-Johnson, Marilyn J.; Weinstein, Mark

2017-01-01

Von Willebrand factor (VWF) mediates blood platelet adhesion and accumulation at sites of blood vessel injury, and also carries coagulation factor VIII (FVIII) that is important for generating procoagulant activity. Von Willebrand disease (VWD), the most common inherited bleeding disorder, affects males and females, and reflects deficiency or defects of VWF that may also cause decreased FVIII. It may also occur less commonly as an acquired disorder (acquired von Willebrand syndrome). This article briefly summarizes selected features of the March 2008 evidence-based clinical and laboratory diagnostic recommendations from the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel for assessment for VWD or other bleeding disorders or risks. Management of VWD is also addressed in the NHLBI guidelines, but is not summarized here. The VWD guidelines are available at the NHLBI Web site (http://www.nhlbi.nih.gov/guidelines/vwd). PMID:19415721

Executive Editor Frank Shushok, Jr. Sits down with Peter Felten and Charles C. Schroeder to Discover What Matters Most for a Meaningful Undergraduate Experience

ERIC Educational Resources Information Center

Shushok, Frank, Jr.

2017-01-01

Peter Felten is executive director of the Center for Engaged Learning and assistant provost for teaching and learning at Elon University, where he also serves as a professor of history. Charles C. Schroeder is the past president of ACPA--College Student Educators International and founding coexecutive editor of "About Campus." Felten and…

Measuring Changes in Tactile Sensitivity in the Hind Paw of Mice Using an Electronic von Frey Apparatus

PubMed Central

Martinov, Tijana; Mack, Madison; Sykes, Akilah; Chatterjea, Devavani

2013-01-01

Measuring inflammation-induced changes in thresholds of hind paw withdrawal from mechanical pressure is a useful technique to assess changes in pain perception in rodents. Withdrawal thresholds can be measured first at baseline and then following drug, venom, injury, allergen, or otherwise evoked inflammation by applying an accurate force on very specific areas of the skin. An electronic von Frey apparatus allows precise assessment of mouse hind paw withdrawal thresholds that are not limited by the available filament sizes in contrast to classical von Frey measurements. The ease and rapidity of measurements allow for incorporation of assessment of tactile sensitivity outcomes in diverse models of rapid-onset inflammatory and neuropathic pain as multiple measurements can be taken within a short time period. Experimental measurements for individual rodent subjects can be internally controlled against individual baseline responses and exclusion criteria easily established to standardize baseline responses within and across experimental groups. Thus, measurements using an electronic von Frey apparatus represent a useful modification of the well-established classical von Frey filament-based assays for rodent mechanical allodynia that may also be applied to other nonhuman mammalian models. PMID:24378519

Professor Oberth and Dr. von Braun at ARS Banquet

NASA Technical Reports Server (NTRS)

1961-01-01

Dr. Wernher von Braun holds the coveted Hermarn Oberth award presented to him by Professor Oberth during the banquet hosted by the Alabama Section of the American Rocket Society (ARS), on October 19, 1961. The Oberth award was given for outstanding technical contributions to the field of astronautics or for the promotion and advancement of astronautical sciences.

Phenotypic correction of von Willebrand disease type 3 blood-derived endothelial cells with lentiviral vectors expressing von Willebrand factor

PubMed Central

De Meyer, Simon F.; Vanhoorelbeke, Karen; Chuah, Marinee K.; Pareyn, Inge; Gillijns, Veerle; Hebbel, Robert P.; Collen, Désiré; Deckmyn, Hans; VandenDriessche, Thierry

2006-01-01

Von Willebrand disease (VWD) is an inherited bleeding disorder, caused by quantitative (type 1 and 3) or qualitative (type 2) defects in von Willebrand factor (VWF). Gene therapy is an appealing strategy for treatment of VWD because it is caused by a single gene defect and because VWF is secreted into the circulation, obviating the need for targeting specific organs or tissues. However, development of gene therapy for VWD has been hampered by the considerable length of the VWF cDNA (8.4 kb [kilobase]) and the inherent complexity of the VWF protein that requires extensive posttranslational processing. In this study, a gene-based approach for VWD was developed using lentiviral transduction of blood-outgrowth endothelial cells (BOECs) to express functional VWF. A lentiviral vector encoding complete human VWF was used to transduce BOECs isolated from type 3 VWD dogs resulting in high-transduction efficiencies (95.6% ± 2.2%). Transduced VWD BOECs efficiently expressed functional vector-encoded VWF (4.6 ± 0.4 U/24 hour per 106 cells), with normal binding to GPIbα and collagen and synthesis of a broad range of multimers resulting in phenotypic correction of these cells. These results indicate for the first time that gene therapy of type 3 VWD is feasible and that BOECs are attractive target cells for this purpose. PMID:16478886

Interpolatability distinguishes LOCC from separable von Neumann measurements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Childs, Andrew M.; Leung, Debbie; Mančinska, Laura

2013-11-15

Local operations with classical communication (LOCC) and separable operations are two classes of quantum operations that play key roles in the study of quantum entanglement. Separable operations are strictly more powerful than LOCC, but no simple explanation of this phenomenon is known. We show that, in the case of von Neumann measurements, the ability to interpolate measurements is an operational principle that sets apart LOCC and separable operations.

Hardware-Abbildung eines videobasierten Verfahrens zur echtzeitfähigen Auswertung von Winkelhistogrammen auf eine modulare Coprozessor-Architektur

NASA Astrophysics Data System (ADS)

Flatt, H.; Tarnowsky, A.; Blume, H.; Pirsch, P.

2010-10-01

Dieser Beitrag behandelt die Abbildung eines videobasierten Verfahrens zur echtzeitfähigen Auswertung von Winkelhistogrammen auf eine modulare Coprozessor-Architektur. Die Architektur besteht aus mehreren dedizierten Recheneinheiten zur parallelen Verarbeitung rechenintensiver Bildverarbeitungsverfahren und ist mit einem RISC-Prozessor verbunden. Eine konfigurierbare Architekturerweiterung um eine Recheneinheit zur Auswertung von Winkelhistogrammen von Objekten ermöglicht in Verbindung mit dem RISC eine echtzeitfähige Klassifikation. Je nach Konfiguration sind für die Architekturerweiterung auf einem Xilinx Virtex-5-FPGA zwischen 3300 und 12 000 Lookup-Tables erforderlich. Bei einer Taktfrequenz von 100 MHz können unabhängig von der Bildauflösung pro Einzelbild in einem 25-Hz-Videodatenstrom bis zu 100 Objekte der Größe 256×256 Pixel analysiert werden. This paper presents the mapping of a video-based approach for real-time evaluation of angular histograms on a modular coprocessor architecture. The architecture comprises several dedicated processing elements for parallel processing of computation-intensive image processing tasks and is coupled with a RISC processor. A configurable architecture extension, especially a processing element for evaluating angular histograms of objects in conjunction with a RISC processor, provides a real-time classification. Depending on the configuration of the architecture extension, 3 300 to 12 000 look-up tables are required for a Xilinx Virtex-5 FPGA implementation. Running at a clock frequency of 100 MHz and independently of the image resolution per frame, 100 objects of size 256×256 pixels are analyzed in a 25 Hz video stream by the architecture.

Space: The Long-Range Future: An Interview with Jesco von Puttkamer.

ERIC Educational Resources Information Center

Lawler, Andrew

1985-01-01

Jesco von Puttkamer manages long-range planning in NASA's Office of Space Flight. He believes that space offers the opportunity to ease global tensions, help the developing world, and create a new global culture off the planet. (Author/RM)

Structure and Reversibility of 2D von Neumann Cellular Automata Over Triangular Lattice

NASA Astrophysics Data System (ADS)

Uguz, Selman; Redjepov, Shovkat; Acar, Ecem; Akin, Hasan

2017-06-01

Even though the fundamental main structure of cellular automata (CA) is a discrete special model, the global behaviors at many iterative times and on big scales could be a close, nearly a continuous, model system. CA theory is a very rich and useful phenomena of dynamical model that focuses on the local information being relayed to the neighboring cells to produce CA global behaviors. The mathematical points of the basic model imply the computable values of the mathematical structure of CA. After modeling the CA structure, an important problem is to be able to move forwards and backwards on CA to understand their behaviors in more elegant ways. A possible case is when CA is to be a reversible one. In this paper, we investigate the structure and the reversibility of two-dimensional (2D) finite, linear, triangular von Neumann CA with null boundary case. It is considered on ternary field ℤ3 (i.e. 3-state). We obtain their transition rule matrices for each special case. For given special triangular information (transition) rule matrices, we prove which triangular linear 2D von Neumann CAs are reversible or not. It is known that the reversibility cases of 2D CA are generally a much challenged problem. In the present study, the reversibility problem of 2D triangular, linear von Neumann CA with null boundary is resolved completely over ternary field. As far as we know, there is no structure and reversibility study of von Neumann 2D linear CA on triangular lattice in the literature. Due to the main CA structures being sufficiently simple to investigate in mathematical ways, and also very complex to obtain in chaotic systems, it is believed that the present construction can be applied to many areas related to these CA using any other transition rules.

Occurrences of whale shark (Rhincodon typus Smith, 1828) in the Saint Peter and Saint Paul archipelago, Brazil.

PubMed

Hazin, F H V; Vaske Júnior, T; Oliveira, P G; Macena, B C L; Carvalho, F

2008-05-01

The Saint Peter and Saint Paul Archipelago in the central tropical Atlantic, is an important ground of whale sharks that are commonly sighted throughout the year close to the fishing boats in the adjacencies of the islands. In sightings reported between February 2000 and November 2005, the lengths of the individuals ranged between 1.8 to 14.0 m. The causes of these concentrations in the archipelago are still unclear, once there are no upwellings and plankton concentrations for feeding, and no reproductive activities were reported. Nevertheless, they could be associated to the spawning period of the abundant flying fishes, mainly in the first semester, when sightings were more frequent.

Inzidenz von bullösen Autoimmunerkrankungen in Serbien: eine retrospektive Studie über 20 Jahre.

PubMed

Milinković, Mirjana; Janković, Slavenka; Medenica, Ljiljana; Nikolić, Miloš; Reljić, Vesna; Popadić, Svetlana; Janković, Janko

2016-10-01

Die meisten früheren Arbeiten zu den klinisch-epidemiologischen Merkmalen von bullösen Autoimmunerkrankungen (AIBD) konzentrierten sich vor allem auf eine einzige Krankheitsentität oder nur eine Krankheitsgruppe; nur in wenigen Studien wurde die Inzidenz verschiedener AIBD untersucht. Bei der vorliegenden Studie war es unser Ziel, das gesamte Spektrum der AIBD zu betrachten, die Inzidenz der häufigsten AIBD zu ermitteln und die zeitlichen Trends ihres Auftretens in Zentralserbien über einen Zeitraum von 20 Jahren zu untersuchen. Wir rekrutierten retrospektiv 1161 AIBD-Fälle, die in Zentralserbien von Januar 1991 bis Dezember 2010 neu diagnostiziert wurden. Die Diagnose stützte sich auf eine strikte klinische, histologische und immunhistologische Beurteilung. Folgende Inzidenzraten wurden für die einzelnen Erkrankungen ermittelt: 4,35 pro eine Million Einwohner/Jahr (pME/Jahr) für Pemphigus, 4,47 pME/Jahr für Pemphigoid, 1,42 pME/Jahr für Dermatitis herpetiformis (DH), 0,25 pME/Jahr IgA-Dermatose und 0,08 pME/Jahr für Epidermolysis bullosa acquisita. Im betrachteten Zeitraum stieg die altersbereinigte Inzidenzrate für Pemphigus und insbesondere für Pemphigoid signifikant an, während sie für DH, allerdings nicht signifikant, abnahm. Unsere Studie befasst sich zum ersten Mal mit den Inzidenzraten des gesamten Spektrums der AIBD in Serbien und untersucht die zeitlichen Trends ihres Auftretens über einen Zeitraum von 20 Jahren. Nach unserem besten Wissen wurde ein ähnlicher Befund wie der unsere, dass nämlich die Inzidenzraten von Pemphigus und Pemphigoid vergleichbar sind, bisher noch nicht publiziert. © 2016 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.

Molecular-genetic diagnostics of von Hippel-Lindau syndrome (VHL) in Bulgaria: first complex mutation event in the VHL gene.

PubMed

Glushkova, Maria; Dimova, Petia; Yordanova, Iglika; Todorov, Tihomir; Tourtourikov, Ivan; Mitev, Vanyo; Todorova, Albena

2018-02-01

Von Hippel-Lindau syndrome is an autosomal-dominant disease characterized by the formation of various tumours and cysts in many different parts of the body. Von Hippel-Lindau syndrome is caused by VHL gene mutations leading to production of impaired tumor suppressor Von Hippel-Lindau syndrome protein or its complete absence. To study five patients with clinically suspected Von Hippel-Lindau syndrome, who were referred for molecular genetic testing. Sanger sequencing of the coding regions of the VHL gene. Five clinically relevant germline mutations were detected. One of the pathogenic variants has not been previously reported. This novel mutation is a complex mutation event combining a duplication and an indel, rearranging exon 3 of the VHL gene - c. [516_517dupGTCAAGCCT; 532_542delCTGGACATCGTinsATTA], p. (Glu173Serfs*4). Overall, our results showed that the diagnosis of Von Hippel-Lindau syndrome in our country is difficult most probably because of its heterogeneous clinical manifestation and insufficient knowledge on the diagnostic criteria for the disease. From genetic point of view our results add some novel data on the mutation profile of the VHL gene. In order to prove or revise the diagnosis, early genetic testing is strongly recommended in affected patients and their family members to ensure appropriate follow-up and treatment of the malignancies.

Generalization of von Neumann analysis for a model of two discrete half-spaces: The acoustic case

USGS Publications Warehouse

Haney, M.M.

2007-01-01

Evaluating the performance of finite-difference algorithms typically uses a technique known as von Neumann analysis. For a given algorithm, application of the technique yields both a dispersion relation valid for the discrete time-space grid and a mathematical condition for stability. In practice, a major shortcoming of conventional von Neumann analysis is that it can be applied only to an idealized numerical model - that of an infinite, homogeneous whole space. Experience has shown that numerical instabilities often arise in finite-difference simulations of wave propagation at interfaces with strong material contrasts. These interface instabilities occur even though the conventional von Neumann stability criterion may be satisfied at each point of the numerical model. To address this issue, I generalize von Neumann analysis for a model of two half-spaces. I perform the analysis for the case of acoustic wave propagation using a standard staggered-grid finite-difference numerical scheme. By deriving expressions for the discrete reflection and transmission coefficients, I study under what conditions the discrete reflection and transmission coefficients become unbounded. I find that instabilities encountered in numerical modeling near interfaces with strong material contrasts are linked to these cases and develop a modified stability criterion that takes into account the resulting instabilities. I test and verify the stability criterion by executing a finite-difference algorithm under conditions predicted to be stable and unstable. ?? 2007 Society of Exploration Geophysicists.

Von recklinghausen neurofibromatosis-pachydermatocele causing lower limb gigantism: a case report.

PubMed

Rekha, Arcot; Gopalan, T R

2006-03-01

Gigantism of the lower limb can occur because of plexiform neurofibromas. This condition is seen with café au lait patches and multiple neurofibromatosis in this case of von Recklinghausen neurofibromatosis. We report our patient and review literature of this uncommon condition.

Delboeuf and Janet as influences in Freud's treatment of Emmy von N.

PubMed

Macmillan, M B

1979-10-01

An analysis is made of Freud's treatment of the patient known as Emmy von N. in which for the first time he used what he called "Breuer's technique of investigation under hypnosis." It is shown that the main component of Freud's therapy owed nothing to Breuer: the patient's traumatic memories were altered by direct suggestion under hypnosis. The abreaction which did take place seems to have resulted from Freud's expectation that it should occur. Two cases published by Delboeuf and Janet in late 1888 and early 1889 were treated by a then unusual method which analysis demonstrates to have been virtually identical to the technique used by Freud. Evidence is presented that the Delboeuf and Janet cases could have been known to Freud before he began his treatment of Emmy von N.

Recurrent haematomas of the thigh: a case of von Willebrand's disease presenting to a sports clinic

PubMed Central

Owens, S.; Baglin, T.

2000-01-01

Von Willebrand's disease is a relatively common mild form of haemophilia. It should be suspected in assessing sports injuries when excessive bleeding occurs in response to relatively mild trauma. Those with the disease should remain active but avoid contact sports. They should not take aspirin or non-steroidal anti-inflammatory drugs, which may exacerbate bleeding, and should be given supportive treatment to cover dental extraction, surgery, or significant bleeding episodes. Key Words: von Willebrand's disease; haemophilia; haematoma; sports clinic PMID:10786868

Reflections on Peter Slezak and the 'Sociology of Scientific Knowledge`

NASA Astrophysics Data System (ADS)

Suchting, W. A.

The paper examines central parts of the first of two papers in this journal by Peter Slezak criticising sociology of scientific knowledge and also considers, independently, some of the main philosophical issues raised by the sociologists of science, in particular David Bloor. The general conclusion is that each account alludes to different and crucial aspects of the nature of knowledge without, severally or jointly, being able to theorise them adequately. The appendix contains epistemological theses central to a more adequate theory of scientific knowledge.... our Histories of six Thousand Moons make no Mention of any other, than the two great Empires of Lilliput and Blefuscu. Which mighty Powers have ... been engaged in a most obstinate War for six and thirty Moons past. It began upon the following Occasion. It is allowed on all Hands, that the primitive Way of breaking Eggs before we eat them, was upon the larger End: But ... the Emperor [of Lilliput] ... published an Edict, commanding all his Subjects, upon great Penalties, to break the smaller End of their Eggs. The People so resented this Law, that ... there have been six Rebellions raised on that Account ... These civil Commotions were constantly fomented by the Monarchs of Blefuscu ... It is computed, that eleven Thousand have, at several Times, suffered Death, rather than break Eggs at the smaller End. Many hundred large Volumes have published upon this Controversy ...

Salivary histatins in human deep posterior lingual glands (of von Ebner).

PubMed

Piludu, Marco; Lantini, Maria Serenella; Cossu, Margherita; Piras, Monica; Oppenheim, Frank G; Helmerhorst, Eva J; Siqueira, Walter; Hand, Arthur R

2006-11-01

Human saliva contains a family of low molecular weight histidine-rich proteins, named histatins, characterised by bactericidal and fungicidal activities in vitro against several microbial pathogens, such as Streptococcus mutans and Candida albicans. They represent a major component of an innate host non-immune defense system. In an earlier study we described the distribution of histatins in the glandular parenchyma of human major salivary glands, confirming that all human major salivary glands are involved in the secretion of histatins into saliva. In the present study we determined the expression and localisation of histatins in human posterior deep lingual glands (von Ebner's glands) by means of immunoelectron microscopy. Thin sections of normal human salivary glands, embedded in Epon resin, were incubated with rabbit polyclonal antibodies specific for human histatins and successively with a gold conjugated goat anti-rabbit IgG used as secondary antibody. Sections incubated with medium devoid of primary antibody or containing non-immune serum were used as controls. The serous secreting cells represented the main source of histatins in the glandular parenchyma of von Ebner's glands. At the electron microscopic level, labeling was associated with rough endoplasmic reticulum, Golgi complex and secretory granules that represented the main cytoplasmic site of histatin localisation. However, variability in the intensity of labeling was observed among adjacent cells. The present results show for the first time that human von Ebner's glands produce and represent a significant source of histatins, supporting the hypothesis of their important role in preventing microbial assaults on the tissues in the posterior region of the tongue and in the circumvallate papillae.

Optimal spinneret layout in Von Koch curves of fractal theory based needleless electrospinning process

NASA Astrophysics Data System (ADS)

Yang, Wenxiu; Liu, Yanbo; Zhang, Ligai; Cao, Hong; Wang, Yang; Yao, Jinbo

2016-06-01

Needleless electrospinning technology is considered as a better avenue to produce nanofibrous materials at large scale, and electric field intensity and its distribution play an important role in controlling nanofiber diameter and quality of the nanofibrous web during electrospinning. In the current study, a novel needleless electrospinning method was proposed based on Von Koch curves of Fractal configuration, simulation and analysis on electric field intensity and distribution in the new electrospinning process were performed with Finite element analysis software, Comsol Multiphysics 4.4, based on linear and nonlinear Von Koch fractal curves (hereafter called fractal models). The result of simulation and analysis indicated that Second level fractal structure is the optimal linear electrospinning spinneret in terms of field intensity and uniformity. Further simulation and analysis showed that the circular type of Fractal spinneret has better field intensity and distribution compared to spiral type of Fractal spinneret in the nonlinear Fractal electrospinning technology. The electrospinning apparatus with the optimal Von Koch fractal spinneret was set up to verify the theoretical analysis results from Comsol simulation, achieving more uniform electric field distribution and lower energy cost, compared to the current needle and needleless electrospinning technologies.

Dreams of death: Von Weizsäcker's Dreams in so-called endogenic anorexia: a research note.

PubMed

Jackson, C; Beumont, P J; Thornton, C; Lennerts, W

1993-04-01

Viktor Von Weizsäcker's paper "Dreams in so-called endogenic Magersucht (anorexia," first published in the Deutsche Medizinische Wochenschrift in 1937 (translation in M. Kaufman & M. Heiman [1964]. Evolution of psychosomatic concepts: Anorexia nervosa: A paradigm (pp. 181-197), New York: International Universities Press, has been described as a noteworthy and historically important contribution to the recognition of anorexia nervosa as a psychosomatic illness. Von Weizsäcker analyzed the dreams of patients he was treating for "endogenous anorexia" (magersucht). He claimed that in the bulimic phase his patients experienced nightmares dealing with themes of death, but that in the anorectic phases of restricted eating more pleasant dreams dealt with themes of blissful contentment. The authors draw current attention to his work as another early example of the treatment of the theme of death and death symbolism in the literature on eating disorders, and suggest some reappraisal of von Weizsäcker's interpretations of his own material.

Wirksamkeit und Sicherheit von Fumarsäureestern in Kombination mit Phototherapie bei Patienten mit moderater bis schwerer Plaque-Psoriasis (FAST).

PubMed

Weisenseel, Peter; Reich, Kristian; Griemberg, Wiebke; Merten, Katharina; Gröschel, Christine; Gomez, Natalie Nunez; Taipale, Kirsi; Bräu, Beate; Zschocke, Ina

2017-02-01

Die Behandlung von Psoriasis-Patienten mit einer Kombination aus Fumarsäureestern (FSE, Fumaderm ® ) und Phototherapie (UV) ist verbreitet, wurde aber im Rahmen von Studien wenig untersucht. Bisher liegen lediglich Daten aus einer kleinen Pilotstudie vor. Intention dieser Studie war, eine FSE/UV-Kombinationsbehandlung an einem größeren Patientenkollektiv mit mittelschwerer bis schwerer Psoriasis zu untersuchen. In dieser prospektiven, multizentrischen, nichtinterventionellen Studie wurden Daten von Patienten mit FSE/UV-Kombinationstherapie hinsichtlich der Wirksamkeit (PGA' PASI, DLQI, EQ-5D), Sicherheit und Dosierung über einen Zeitraum von zwölf Monaten erfasst und mit Daten einer retrospektiven Studie mit FSE-Monotherapie verglichen. Es wurden Daten von 363 Patienten ausgewertet. Unter der Kombinationstherapie verbesserten sich alle Wirksamkeitsparameter deutlich. Im Vergleich zur Monotherapie mit FSE konnte durch die Kombination mit UV ein schnellerer Wirkeintritt erzielt werden, wobei nach zwölf Monaten kein Unterschied in der Wirksamkeit bestand. Die Dauer und Art der Phototherapie zeigte keinen Einfluss auf die Wirksamkeitsparameter. Allgemein wurde die Kombinationstherapie gut vertragen. Unerwünschte Ereignisse wurden bei 7 % der Patienten berichtet. Die FSE/UV Kombinationstherapie zeigt eine gute Wirksamkeit und Verträglichkeit und kann zu einem schnelleren Wirkeintritt führen. Eine Kombinationstherapie erscheint vor allem in den ersten drei Monaten der FSE Behandlung sinnvoll. © 2017 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.

Optimal projection method determination by Logdet Divergence and perturbed von-Neumann Divergence.

PubMed

Jiang, Hao; Ching, Wai-Ki; Qiu, Yushan; Cheng, Xiao-Qing

2017-12-14

Positive semi-definiteness is a critical property in kernel methods for Support Vector Machine (SVM) by which efficient solutions can be guaranteed through convex quadratic programming. However, a lot of similarity functions in applications do not produce positive semi-definite kernels. We propose projection method by constructing projection matrix on indefinite kernels. As a generalization of the spectrum method (denoising method and flipping method), the projection method shows better or comparable performance comparing to the corresponding indefinite kernel methods on a number of real world data sets. Under the Bregman matrix divergence theory, we can find suggested optimal λ in projection method using unconstrained optimization in kernel learning. In this paper we focus on optimal λ determination, in the pursuit of precise optimal λ determination method in unconstrained optimization framework. We developed a perturbed von-Neumann divergence to measure kernel relationships. We compared optimal λ determination with Logdet Divergence and perturbed von-Neumann Divergence, aiming at finding better λ in projection method. Results on a number of real world data sets show that projection method with optimal λ by Logdet divergence demonstrate near optimal performance. And the perturbed von-Neumann Divergence can help determine a relatively better optimal projection method. Projection method ia easy to use for dealing with indefinite kernels. And the parameter embedded in the method can be determined through unconstrained optimization under Bregman matrix divergence theory. This may provide a new way in kernel SVMs for varied objectives.

Synesthesia and memory: color congruency, von Restorff, and false memory effects.

PubMed

Radvansky, Gabriel A; Gibson, Bradley S; McNerney, M Windy

2011-01-01

In the current study, we explored the influence of synesthesia on memory for word lists. We tested 10 grapheme-color synesthetes who reported an experience of color when reading letters or words. We replicated a previous finding that memory is compromised when synesthetic color is incongruent with perceptual color. Beyond this, we found that, although their memory for word lists was superior overall, synesthetes did not exhibit typical color- or semantic-defined von Restorff isolation effects (von Restorff, 1933) compared with control participants. Moreover, our synesthetes exhibited a reduced Deese-Roediger-McDermott false memory effect (Deese, 1959; Roediger & McDermott, 1995). Taken as a whole, these findings are consistent with the idea that color-grapheme synesthesia can lead people to place a greater emphasis on item-specific processing and surface form characteristics of words in a list (e.g., the letters that make them up) relative to relational processing and more meaning-based processes. (PsycINFO Database Record (c) 2010 APA, all rights reserved).

von Willebrand factor, Jedi knight of the bloodstream.

PubMed

Springer, Timothy A

2014-08-28

When blood vessels are cut, the forces in the bloodstream increase and change character. The dark side of these forces causes hemorrhage and death. However, von Willebrand factor (VWF), with help from our circulatory system and platelets, harnesses the same forces to form a hemostatic plug. Force and VWF function are so closely intertwined that, like members of the Jedi Order in the movie Star Wars who learn to use "the Force" to do good, VWF may be considered the Jedi knight of the bloodstream. The long length of VWF enables responsiveness to flow. The shape of VWF is predicted to alter from irregularly coiled to extended thread-like in the transition from shear to elongational flow at sites of hemostasis and thrombosis. Elongational force propagated through the length of VWF in its thread-like shape exposes its monomers for multimeric binding to platelets and subendothelium and likely also increases affinity of the A1 domain for platelets. Specialized domains concatenate and compact VWF during biosynthesis. A2 domain unfolding by hydrodynamic force enables postsecretion regulation of VWF length. Mutations in VWF in von Willebrand disease contribute to and are illuminated by VWF biology. I attempt to integrate classic studies on the physiology of hemostatic plug formation into modern molecular understanding, and point out what remains to be learned. © 2014 by The American Society of Hematology.

The Digital Von Fahrenheid Pyramid

NASA Astrophysics Data System (ADS)

Bura, M.; Janowski, J.; Wężyk, P.; Zięba, K.

2017-08-01

3D Scanners Lab from Digital Humanities Laboratory at the University of Warsaw initiated the scientific project, the purpose of which was to call attention to systematically penetrated and devastated pyramid-shaped tomb from the XVIII/XIX century, of family von Fahrenheid in Rapa in Banie Mazurskie commune (NE Poland). By conducting a series of non-invasive studies, such as 3D inventory using terrestrial laser scanning (TLS), thermal imaging, georadar measurements (around and inside the tomb) and anthropological research of mummified remains as well - the complete dataset was collected. Through the integration of terrestrial (TLS) and airborne laser scanning (ALS) authors managed to analyse the surroundings of Fahrenheid pyriamid and influence of some objects (like trees) on the condition and visibility of the Pyramids in the landscape.

On the history of Ludwig von Bertalanffy's "general systemology", and on its relationship to cybernetics - Part II: Contexts and developments of the systemological hermeneutics instigated by von Bertalanffy

NASA Astrophysics Data System (ADS)

Pouvreau, David

2014-02-01

The history of "general system theory" is investigated in order to clarify its meanings, vocations, foundations and achievements. It is characterized as the project of a science of the systemic interpretation of the "real", renamed here "general systemology". The contexts and modes of its elaboration, publication and implementation are discussed. The paper mostly focuses on the works of its instigator: Ludwig von Bertalanffy. However, general systemology was a collective project: the main contributions of other "systemologists", from the 1950s until the 1970s, are hence also considered. Its solidarity with the history of the Society for General Systems Research is notably discussed. A reconstruction of the systemological hermeneutics is undertaken on this basis. It finds out the potential systematic unity underlying the diversity of the contributions to this both scientific and philosophical project. Light is thus shed on the actual scope of von Bertalanffy's works.

Von Willebrand's disease with spontaneous platelet aggregation induced by an abnormal plasma von Willebrand factor.

PubMed Central

Grainick, H R; Williams, S B; McKeown, L P; Rick, M E; Maisonneuve, P; Jenneau, C; Sultan, Y

1985-01-01

We have investigated and characterized the abnormalities in four unrelated patients with von Willebrand's disease (vWd) who have (a) enhanced ristocetin-induced platelet aggregation (RIPA) at low ristocetin concentrations, (b) absence of the largest plasma von Willebrand factor (vWf) multimers, and (c) thrombocytopenia. The platelet-rich plasma of these patients aggregates spontaneously without the addition of any agonists. When isolated normal platelets are resuspended in patient plasma spontaneous aggregation occurs; however, the patients' plasmas did not induce platelet aggregation of normal washed formalinized platelets. When the patients' platelets are suspended in normal plasma, spontaneous aggregation is not observed. The spontaneous platelet aggregation (SPA) is associated with dense granule secretion as measured by ATP release and alpha granule release as measured by beta-thromboglobulin and platelet factor 4 release. The SPA is totally inhibited by 5 mM EDTA, prostaglandin I2, and dibutryl cyclic AMP, while it is only partially inhibited by 1 mM EDTA, acetylsalicylic acid, or apyrase. A monoclonal antibody directed against glycoprotein Ib (GPIb) and/or a monoclonal antibody against the glycoprotein IIb/IIIa (GPIIb/IIIa) complex totally inhibits the SPA. The vWf was isolated from the plasma of one of these patients. The purified vWf induced platelet aggregation of normal platelets resuspended in either normal or severe vWd plasma, but the vWf did not induce platelet aggregation of normal platelets resuspended in afibrinognemic plasma. Sialic acid and galactose quantification of the patient's vWf revealed approximately a 50% reduction compared with normal vWf. These studies indicate that a form of vWd exists, which is characterized by SPA that is induced by the abnormal plasma vWf. The SPA is dependent on the presence of plasma fibrinogen, and the availability of the GPIb and the GPIIb/IIIa complex. In this variant form of vWd the abnormal vWf causes

Albert Einstein and Wernher von Braun - the two great German-American physicists seen in a historical perspective.

NASA Astrophysics Data System (ADS)

Winterberg, Friedwardt

2008-04-01

It was Albert Einstein who for the first time changed our view of the universe to be a non-euclidean curved space-time. And it was Wernher von Braun who blazed the trail to take us into this universe, leaving for the first time the gravitational field of our planet earth, with the landing a man on the moon the greatest event in human history. Both these great physicists did this on the shoulders of giants. Albert Einstein on the shoulders of his landsman, the mathematician Bernhard Riemann, and Wernher von Braun on the shoulders of Goddard and Oberth. Both Einstein and von Braun made a Faustian pact with the devil, von Braun by accepting research funds from Hitler, and Einstein by urging Roosvelt to build the atom bomb (against Hitler). Both of these great men later regretted the use of their work for the killing of innocent bystanders, even though in the end the invention of nuclear energy and space flight is for the benefit of man. Their example serves as a warning for all of us. It can be formulated as follows: ``Can I in good conscience accept research funds from the military to advance scientific knowledge, for weapons developed against an abstract enemy I never have met in person?'' Weapons if used do not differentiate between the scientist, who invented these weapons, and the non-scientist.

Effects of fouling on the Japanese scallop Mizuhopecten yessoensis (Jay) in Peter the Great Bay (Sea of Japan)

NASA Astrophysics Data System (ADS)

Gabaev, D. D.

2013-03-01

A valuable mariculture object, the Japanese scallop Mizuhopecten (= Patinopevten) yessoensis (Jay), after six hours long transportation by air and sowing on the bottom is fouled greater by epi- and endolythical organisms than the members of the native population. It is likely that the fouling negatively affects the specimens, those that were the largest before the sowing at the bottom were not found among those that reached puberty. The results of the effects of the endolythic polychaete Polydora brevipalpa and the barnacle Hesperibalanus hesperius on the growth rate of the Japanese scallop cultivated on the bottom of Peter the Great Bay (Sea of Japan) are provided in this paper.

Spontaneous haemothorax: a cause of sudden death in von Recklinghausen's disease.

PubMed Central

Griffiths, A. P.; White, J.; Dawson, A.

1998-01-01

Vasculopathy is a relatively frequent but poorly recognised manifestation of von Recklinghausen's neurofibromatosis. One of its more dramatic presentations is as spontaneous haemothorax. Clinicians and pathologists should be aware of this syndrome as a cause of sudden death in patients with neurofibromatosis. Images Figure 1 Figure 2 PMID:10197217

Two errors in enteric epidemiology: the stories of Austin Flint and Max von Pettenkofer.

PubMed

Evans, A S

1985-01-01

The misconceptions of two physicians, Austin Flint and Max von Pettenkofer, in interpreting epidemiologic data on the water transmission of enteric disease are reviewed. Austin Flint failed to recognize the transmission of typhoid fever from well water in an epidemic he investigated in North Boston, New York, in 1843. He later discovered and freely admitted his error. Max von Pettenkofer, who had studied cholera in the 1854 outbreak and in many subsequent outbreaks, failed to confirm John Snow's observations in England on the water transmission of cholera. Pettenkofer eventually swallowed live cholera bacilli and did not develop cholera. He remained convinced to the end of his life that cholera is not directly transmitted by drinking water.

Effects of Turbulence Model and Numerical Time Steps on Von Karman Flow Behavior and Drag Accuracy of Circular Cylinder

NASA Astrophysics Data System (ADS)

Amalia, E.; Moelyadi, M. A.; Ihsan, M.

2018-04-01

The flow of air passing around a circular cylinder on the Reynolds number of 250,000 is to show Von Karman Vortex Street Phenomenon. This phenomenon was captured well by using a right turbulence model. In this study, some turbulence models available in software ANSYS Fluent 16.0 was tested to simulate Von Karman vortex street phenomenon, namely k- epsilon, SST k-omega and Reynolds Stress, Detached Eddy Simulation (DES), and Large Eddy Simulation (LES). In addition, it was examined the effect of time step size on the accuracy of CFD simulation. The simulations are carried out by using two-dimensional and three- dimensional models and then compared with experimental data. For two-dimensional model, Von Karman Vortex Street phenomenon was captured successfully by using the SST k-omega turbulence model. As for the three-dimensional model, Von Karman Vortex Street phenomenon was captured by using Reynolds Stress Turbulence Model. The time step size value affects the smoothness quality of curves of drag coefficient over time, as well as affecting the running time of the simulation. The smaller time step size, the better inherent drag coefficient curves produced. Smaller time step size also gives faster computation time.

Richard von Volkmann

PubMed Central

Willy, Christian; Schneider, Peter; Engelhardt, Michael; Hargens, Alan R.

2008-01-01

Richard von Volkmann (1830–1889), one of the most important surgeons of the 19th century, is regarded as one of the fathers of orthopaedic surgery. He was a contemporary of Langenbeck, Esmarch, Lister, Billroth, Kocher, and Trendelenburg. He was head of the Department of Surgery at the University of Halle, Germany (1867–1889). His popularity attracted doctors and patients from all over the world. He was the lead physician for the German military during two wars. From this experience, he compared the mortality of civilian and war injuries and investigated the general poor hygienic conditions in civilian hospitals. This led him to introduce the “antiseptic technique” to Germany that was developed by Lister. His powers of observation and creativity led him to findings and achievements that to this day bear his name: Volkmann’s contracture and the Hueter-Volkmann law. Additionally, he was a gifted writer; he published not only scientific literature but also books of children’s fairy tales and poems under the pen name of Richard Leander, assuring him a permanent place in the world of literature as well as orthopaedics. PMID:18196438

N-linked glycan truncation causes enhanced clearance of plasma-derived von Willebrand factor.

PubMed

O'Sullivan, J M; Aguila, S; McRae, E; Ward, S E; Rawley, O; Fallon, P G; Brophy, T M; Preston, R J S; Brady, L; Sheils, O; Chion, A; O'Donnell, J S

2016-12-01

Essentials von Willebrands factor (VWF) glycosylation plays a key role in modulating in vivo clearance. VWF glycoforms were used to examine the role of specific glycan moieties in regulating clearance. Reduction in sialylation resulted in enhanced VWF clearance through asialoglycoprotein receptor. Progressive VWF N-linked glycan trimming resulted in increased macrophage-mediated clearance. Click to hear Dr Denis discuss clearance of von Willebrand factor in a free presentation from the ISTH Academy SUMMARY: Background Enhanced von Willebrand factor (VWF) clearance is important in the etiology of both type 1 and type 2 von Willebrand disease (VWD). In addition, previous studies have demonstrated that VWF glycans play a key role in regulating in vivo clearance. However, the molecular mechanisms underlying VWF clearance remain poorly understood. Objective To define the molecular mechanisms through which VWF N-linked glycan structures influence in vivo clearance. Methods By use of a series of exoglycosidases, different plasma-derived VWF (pd-VWF) glycoforms were generated. In vivo clearance of these glycoforms was then assessed in VWF -/- mice in the presence or absence of inhibitors of asialoglycoprotein receptor (ASGPR), or following clodronate-induced macrophage depletion. Results Reduced amounts of N-linked and O-linked sialylation resulted in enhanced pd-VWF clearance modulated via ASGPR. In addition to this role of terminal sialylation, we further observed that progressive N-linked glycan trimming also resulted in markedly enhanced VWF clearance. Furthermore, these additional N-linked glycan effects on clearance were ASGPR-independent, and instead involved enhanced macrophage clearance that was mediated, at least in part, through LDL receptor-related protein 1. Conclusion The carbohydrate determinants expressed on VWF regulate susceptibility to proteolysis by ADAMTS-13. In addition, our findings now further demonstrate that non-sialic acid carbohydrate

[Catering services bases in the Russian army under military regulation of Peter the Great].

PubMed

Konyshev, I S; adamenko, A M; Koshelev, V P

2014-01-01

At Peter I the regular army was organized and the system of target state deliveries to troops of the food is created. Provisioning and fodder was normalized as portion and ration. Portion was contained the products forpeoplefood, and ration - fodder for horses food who were used by the serviceman. Portion and ration unit was identical to all categories of the military personnel. Difference in food level consisted in that, how many portions and rations serviceman received. Up to the end of existence of Russian army in 1918 in each rota there were contractor and the cook who were engaged in foodstuff and cooking under sergeant-major and one of rota officers supervision. According to the Charter it was necessary to carry with respect and attention to officers and soldiers, their needs, including in the field of supply and catering services and providing with the food: Despite the lack of scientific justification, soldiers' nutrition was sufficient to provide fighting capacity of the Russian army.

Gravity Effects in Diffusive Coarsening of Bubble Lattices: von Neumann's Law

NASA Technical Reports Server (NTRS)

Noever, David A.

2000-01-01

von Neumann modelled the evolution of two-dimensional soap froths as a purely diffusive phenomenon; the area growth of a given cell was found to depend only on the geometry of the bubble lattice. In the model, hexagons are stable, pentagons shrink and heptagons grow. The simplest equivalent to the area growth law is / approximately t(sub beta). The result depends on assuming (1) an incompressible gas; (2) bubble walls which meet at 120 deg and (3) constant wall thickness and curvature. Each assumption is borne out in experiments except the last one: bubble wall thickness between connecting cells varies in unit gravity because of gravity drainage. The bottom part of the soap membrane is thickened, the top part is thinned, such that gas diffusion across the membrane shows a complex dependence on gravity. As a result, experimental tests of von Neumann's law have been influenced by effects of gravity; fluid behavior along cell borders can give non-uniform wall thicknesses and thus alter the effective area and gas diffusion rates between adjacent bubbles. For area plotted as a function of time, Glazier (J.A. Glazier, S.P. Gross, and I. Stavans, Phys. Rev. A. 36, 306 (1987); J. Stavans, J.A, Glazier, Phys. Rev. Lett. 62, 1318 (1989).) suggest that in some cases their failure to observe von Neumann's predicted growth exponent ((sup beta)theor(sup =1; beta)exp(sup =0.70 + 0.10)) may have been the result of such "fluid drainage onto the lower glass plate". Additional experiments which varied plate spacing gave different beta exponents in a fashion consistent with this suggestion. During preliminary long duration experiments (approximately 100 h) aboard Spacelab-J, a low-gravity test of froth coarsening has examined (1) power law scaling of von Neumann's law (beta values) in the appropriate diffusive limits; (2) new bubble lattice dynamics such as greater fluid wetting behavior on froth membranes in low gravity; and (3) explicit relations for the gravity

Earthquake Magnitude Relationships for the Saint Peter and Saint Paul Archipelago, Equatorial Atlantic

NASA Astrophysics Data System (ADS)

de Melo, Guilherme W. S.; do Nascimento, Aderson F.

2018-03-01

We have investigated several relationships between ML, M(NEIC) and Mw for the earthquakes locally recorded in the Saint Peter and Saint Paul Archipelago (SPSPA), Equatorial Atlantic. Because we only have one station in the area, we could not derive attenuation relations for events recorded at different distances at different stations. Our approach was then to compare our ML estimates with magnitudes reported by NEIC. This approach produced acceptable results particularly for epicentral distance smaller than 100 km. For distances greater that 100 km, there is a systematic increase in the residuals probable due to the lack of station correction and our inability to accurately estimate Q. We also investigate the Mw—M(NEIC) relationship. We find that Mw estimates using S-wave produce smaller residuals when compared with both M(NEIC). Finally, we also investigate the ML—Mw relationship and observe that given the data set we have, the 1:1 holds. We believe that the use of the present methodologies provide consistent magnitude estimates between all the magnitudes investigated that could be used to better assess seismic hazard in the region.

Earthquake Magnitude Relationships for the Saint Peter and Saint Paul Archipelago, Equatorial Atlantic

NASA Astrophysics Data System (ADS)

de Melo, Guilherme W. S.; do Nascimento, Aderson F.

2017-12-01

We have investigated several relationships between ML, M(NEIC) and Mw for the earthquakes locally recorded in the Saint Peter and Saint Paul Archipelago (SPSPA), Equatorial Atlantic. Because we only have one station in the area, we could not derive attenuation relations for events recorded at different distances at different stations. Our approach was then to compare our ML estimates with magnitudes reported by NEIC. This approach produced acceptable results particularly for epicentral distance smaller than 100 km. For distances greater that 100 km, there is a systematic increase in the residuals probable due to the lack of station correction and our inability to accurately estimate Q. We also investigate the Mw—M(NEIC) relationship. We find that Mw estimates using S-wave produce smaller residuals when compared with both M(NEIC). Finally, we also investigate the ML—Mw relationship and observe that given the data set we have, the 1:1 holds. We believe that the use of the present methodologies provide consistent magnitude estimates between all the magnitudes investigated that could be used to better assess seismic hazard in the region.

Book Review: John von Neumann and the foundations of quantum physics. (Vienna Circle Institute yearbook (2000), 8) Miklos Redei and Michael Stoltzner (Eds.); Kluwer Academic Publishers, Dordrecht, 2001, pp., US 125, ISBN 0792368126

NASA Astrophysics Data System (ADS)

Lupher, Tracy

2003-12-01

Some people may be surprised to learn that John von Neumann's work on the foundations of quantum physics went far beyond what is contained within the pages of his Mathematical Foundations of Quantum Mechanics (MFQM) (von Neumann, 1955). However, this narrow focus often ignores von Neumann's later work on quantum logic and what are now called in his honor, von Neumann algebras. This volume honoring von Neumann's contributions to physics is unique in that, while it contains 12 papers that examine various aspects of von Neumann's work, it also contains two of his previously unpublished papers and some of his previously unpublished correspondence.

Peter Bourne’s Drug Policy and the Perils of a Public Health Ethic, 1976–1978

PubMed Central

Dufton, Emily

2015-01-01

As President Jimmy Carter’s advisor for health issues, Peter Bourne promoted a rational and comprehensive drug strategy that combined new supply-side efforts to prevent drug use with previously established demand-side addiction treatment programs. Using a public health ethic that allowed the impact of substances on overall population health to guide drug control, Bourne advocated for marijuana decriminalization as well as increased regulations for barbiturates. A hostile political climate, a series of rumors, and pressure from both drug legalizers and prohibitionists caused Bourne to resign in disgrace in 1978. We argue that Bourne’s critics used his own public health framework to challenge him, describe the health critiques that contributed to Bourne’s resignation, and present the story of his departure as a cautionary tale for today’s drug policy reformers. PMID:25521893

[Urology and National Socialism: the fate of Alexander von Lichtenberg 1880-1949].

PubMed

Moll, F H; Krischel, M; Rathert, P; Fangerau, H

2010-09-01

Alexander von Lichtenberg (1880-1949) was one of the famous members of the German Urological Society (DGU) in pre-war Germany. He introduced excretion urography and a special TURP Instrument. In 1928 he was president of the 8th meeting held in the German capital Berlin. His Handbook of Urology, released by Ferdinand Springer publishing house, was a trendsetter in establishing urology as a specialty in Germany and bringing together the whole wisdom of all aspects of urology. He was the founder of the famous Maximilian Nitze Award of the DGU. As a Jew he-like many others-was forced to leave Nazi Germany after 1933. Even in Hungary, his native country, he again had to resist anti-Semitic hostility. Later on he lived in Mexico. Alexander von Lichtenberg has to be remembered with special focus on the exodus of German Jewish scientists during the Nazi time.

von Kármán swirling flow between a rotating and a stationary smooth disk: Experiment

NASA Astrophysics Data System (ADS)

Mukherjee, Aryesh; Steinberg, Victor

2018-01-01

Precise measurements of the torque in a von Kármán swirling flow between a rotating and a stationary smooth disk in three Newtonian fluids with different dynamic viscosities are reported. From these measurements the dependence of the normalized torque, called the friction coefficient, on Re is found to be of the form Cf=1.17 (±0.03 ) Re-0.46±0.003 where the scaling exponent and coefficient are close to that predicted theoretically for an infinite, unshrouded, and smooth rotating disk which follows from an exact similarity solution of the Navier-Stokes equations, obtained by von Kármán. An error analysis shows that deviations from the theory can be partially caused by background errors. Measurements of the azimuthal Vθ and axial velocity profiles along radial and axial directions reveal that the flow core rotates at Vθ/r Ω ≃0.22 (up to z ≈4 cm from the rotating disk and up to r0/R ≃0.25 in the radial direction) in spite of the small aspect ratio of the vessel. Thus the friction coefficient shows scaling close to that obtained from the von Kármán exact similarity solution, but the observed rotating core provides evidence of the Batchelor-like solution [Q. J. Mech. Appl. Math. 4, 29 (1951), 10.1093/qjmam/4.1.29] different from the von Kármán [Z. Angew. Math. Mech. 1, 233 (1921), 10.1002/zamm.19210010401] or Stewartson [Proc. Camb. Philos. Soc. 49, 333 (1953), 10.1017/S0305004100028437] one.

Prenatal stress-induced increases in hippocampal von Willebrand factor expression are prevented by concurrent prenatal escitalopram

PubMed Central

Neigh, Gretchen N.; Nemeth, Christina L; Kelly, Sean D.; Hardy, Emily E.; Bourke, Chase; Stowe, Zachary N.; Owens, Michael J.

2016-01-01

Prenatal stress has been linked to deficits in neurological function including deficient social behavior, alterations in learning and memory, impaired stress regulation, and susceptibility to adult disease. In addition, prenatal environment is known to alter cardiovascular health; however, limited information is available regarding the cerebrovascular consequences of prenatal stress exposure. Vascular disturbances late in life may lead to cerebral hypoperfusion which is linked to a variety of neurodegenerative and psychiatric diseases. The known impact of cerebrovascular compromise on neuronal function and behavior highlights the importance of characterizing the impact of stress on not just neurons and glia, but also cerebrovasculature. Von Willebrand factor has previously been shown to be impacted by prenatal stress and is predictive of cerebrovascular health. Here we assess the impact of prenatal stress on von Willebrand factor and related angiogenic factors. Furthermore, we assess the potential protective effects of concurrent anti-depressant treatment during in utero stress exposure on the assessed cerebrovascular endpoints. Prenatal stress augmented expression of von Willebrand factor which was prevented by concurrent in utero escitalopram treatment. The functional implications of this increase in von Willebrand factor remain elusive, but the presented data demonstrate that although prenatal stress did not independently impact total vascularization, exposure to chronic stress in adulthood decreased blood vessel length. In addition, the current study demonstrates that production of reactive oxygen species in the hippocampus is decreased by prenatal exposure to escitalopram. Collectively, these findings demonstrate that the prenatal experience can cause complex changes in adult cerebral vascular structure and function. PMID:27422674

Determining the von Mises stress power spectral density for frequency domain fatigue analysis including out-of-phase stress components

NASA Astrophysics Data System (ADS)

Bonte, M. H. A.; de Boer, A.; Liebregts, R.

2007-04-01

This paper provides a new formula to take into account phase differences in the determination of an equivalent von Mises stress power spectral density (PSD) from multiple random inputs. The obtained von Mises PSD can subsequently be used for fatigue analysis. The formula was derived for use in the commercial vehicle business and was implemented in combination with Finite Element software to predict and analyse fatigue failure in the frequency domain.

BOOK REVIEW: Meilensteine der Astronomie - Von Aristoteles bis Hawking

NASA Astrophysics Data System (ADS)

Duerbeck, H. W.; Hamel, J.

2006-12-01

A writer, more specific a writer on the history of astronomy, might from time to time look at the collected document folders with all the research material and reprints, and might wonder: has this been all? Especially at a time when recycling is in vogue? And, perhaps with a request or an invitation to submit something, he or she might consider re-using the material before its definitive disposal. Well, such are my feelings when I looked at Jurgen Hamel's new book Milestones of Astronomy - From Aristoteles to Hawking . A slight chance for survival of medium-sized publishers like Kosmos is to offer popular books, and a title must attract potential buyers: Aristoteles means the "old" times, and as concerns the "mad scientist" of modern times, Stephen Hawking has by now dethroned Einstein. In 1998, Hamel had published a Geschichte der Astronomie - Von den Anfangen bis zur Gegenwart (History of astronomy, from the beginnings to the present), which, of course, he could not simply copy. This time, he selected some stones from his research areas - milestones, touchstones, stumbling blocks in the long road of astronomical evolution - and put them between the covers of his new book. So let us look at these (mile)stones . The reader is informed about Aristoteles on 2 pages, but his medieval interpreter Johannes de Sacrobosco gets 8 pages! Copernicus' life and achievements are described on 9 pages, closely followed by his devotee and translator Rothmann with 8 pages; Copernicus' contemporary, Peter Apian, however, gets about 13! Bessel's and Herschel's lifes and works are described on well-deserved 13 and 15 pages, while the achievements of the two Lucasian professors, Isaac Newton and Stephen Hawking, are just outlined in a single paragraph! Thus, importance is sometimes inversely proportional to text length... But let us become serious now. Why should an active historian outline, for the hundreth time, the life of Copernicus, while there are so many interesting, and often

Peter Becker and his Nazi past: the man behind Becker muscular dystrophy and Becker myotonia.

PubMed

Zeidman, Lawrence A; Kondziella, Daniel

2014-04-01

Peter Becker was a German neurologist who helped classify the muscular dystrophies, and described Becker muscular dystrophy and Becker myotonia. His involvement in National Socialism began in 1933, when he was compelled by his peers to join the SA (brown shirts). He later joined the Nazi party, the Nazi Doctors Association, and the Nazi Lecturers' Association. He renewed his SA membership to maintain his position at a genetics institute. Colleagues stated postwar that he was not an active Nazi, and he was de-Nazified in 1947, able to continue his career. Later, Becker admitted to most, but not all, of his Nazi memberships in his autobiography, and wrote 2 books exploring the origins of Nazism and racial hygiene. The "neurologic court of opinion" must weigh in on how we should best remember Becker, and at the very least, we as neurologists must learn the dangers of career opportunism at any cost.

Platelet von Willebrand factor in Hermansky-Pudlak syndrome.

PubMed

McKeown, L P; Hansmann, K E; Wilson, O; Gahl, W; Gralnick, H R; Rosenfeld, K E; Rosenfeld, S J; Horne, M K; Rick, M E

1998-10-01

The Hermansky-Pudlak Syndrome (HPS) is an autosomal recessive inherited disorder characterized by oculocutaneous albinism, tissue accumulation of ceroid pigment, and a mild to moderate bleeding diathesis attributed to storage-pool deficient (SPD) platlets. Patients have platelet aggregation and release abnormalities. In addition, low levels of plasma von Willebrand factor (vWF) antigen in some HPS patients have been associated with a greater bleeding tendency than would be predicted from either condition alone. Other HPS patients have severe bleeding despite normal levels of plasma vWF, suggesting that at least one additional factor is responsible for their bleeding diathesis. Because platelet vWF levels have been well correlated with clinical bleeding times in patients with von Willebrand's disease, we have measured the platelet vWF activity and antigen levels in 30 HPS patients and have attempted to correlate their clinical bleeding with these values. The platelet vWF activity levels in patients was significantly lower than that of normal subjects (P < 0.0001). The patients as a group also had slightly lower values of plasma vWF activity when compared with normals (P-0.03). In 11 of the HPS patients, the multimeric structure of plasma vWF showed a decrease in the high molecular weight multimers and an increase in the low molecular weight multimers. In correlating the platelet and plasma vWF values with the bleeding histories, we were not able to show a predictable relationship in the majority of the patients.

Analysis of subsequent publication and impact of abstracts presented at the Sir Peter Freyer Surgical Symposium: Focus on the Plenary Session.

PubMed

O' Connor, D J; Lowery, A J; Kearney, D; McAnena, O J; Sweeney, K J; Kerin, M J

2015-09-01

The quality of abstracts presented at a conference reflects the academic activity and research productivity of the surgical/scientific association concerned. The abstract to publication rate (44.5 % internationally), is an important indicator of the quality of presented research. To evaluate the publication rate and impact of abstracts presented at the plenary session of the Sir Peter Freyer Surgical Symposium over a 25-year period (1989-2014), and identify factors influencing publication. Plenary abstracts were identified from abstract books of the Symposium from 1989-2014. The authors, institution, subspecialty and research subject were recorded. A Medline search with name of the first and last author, key words and content of all abstracts was conducted to identify related publications. The impact factor (IF) of the journal and the time to publication was recorded. 298 presented abstracts resulted in 168 publications (publication rate: 56 %). Basic Science research accounted for 80 % (n = 237) of the total number of presentations with the remaining 20 % (n = 61) being categorised as clinical research. Overall, cancer research accounted for 48 % of presented work. The average time to publication was 2 ± 7 years, while 11 % of all published studies achieved publication in the year of the symposium. The median impact factor for published research was 3.558 (IF range 0-39). These results indicate that the quality of papers presented at the Sir Peter Freyer Surgical Symposium compares favourably with international equivalents, making this meeting an important forum for Irish Academic Surgery.

Expression of von Willebrand factor and caldesmon in the placental tissues of pregnancies complicated with intrauterine growth restriction.

PubMed

Göksever Çelik, Hale; Uhri, Mehmet; Yildirim, Gökhan

2017-11-02

The decreased placental perfusion is the underlying reason for intrauterine growth restriction that in turn leads to reduced placental perfusion and ischemia. However, there are several issues to be understood in the pathophysiology of intrauterine growth restriction. We aimed to study whether any compensatory response in placental vascular bed occur in pregnancies complicated with intrauterine growth restriction by the immunohistochemical staining of von Willebrand factor and caldesmon in placental tissues. A total of 103 pregnant women was enrolled in the study including 50 patients who were complicated with IUGR and 50 uncomplicated control patients. The study was designed in a prospective manner. All placentas were also stained with von Willebrand factor and caldesmon monoclonal kits. The immunohistochemical staining of von Willebrand factor and caldesmon expressions in placental tissues were different between normal and intrauterine growth restriction group. The percentages of 2+ and 3+ von Willebrand factor expression were higher in the intrauterine growth restriction group comparing with the normal group, although the difference was not statistically significant. The intensity of caldesmon expression was significantly lower in the intrauterine growth restriction group in comparison with the normal group (p < .001). Angiogenesis occurs as a placental response to intrauterine growth restriction which is a hypoxic condition. But newly formed vessels are immature and not strong enough. Our study is important to clarify the pathophysiology and placental compensatory responses in intrauterine growth restriction.

Platelet Dysfunction and a High Bone Mass Phenotype in a Murine Model of Platelet-Type von Willebrand Disease

PubMed Central

Suva, Larry J.; Hartman, Eric; Dilley, Joshua D.; Russell, Susan; Akel, Nisreen S.; Skinner, Robert A.; Hogue, William R.; Budde, Ulrich; Varughese, Kottayil I.; Kanaji, Taisuke; Ware, Jerry

2008-01-01

The platelet glycoprotein Ib-IX receptor binds surface-bound von Willebrand factor and supports platelet adhesion to damaged vascular surfaces. A limited number of mutations within the glycoprotein Ib-IX complex have been described that permit a structurally altered receptor to interact with soluble von Willebrand factor, and this is the molecular basis of platelet-type von Willebrand disease. We have developed and characterized a mouse model of platelet-type von Willebrand disease (G233V) and have confirmed a platelet phenotype mimicking the human disorder. The mice have a dramatic increase in splenic megakaryocytes and splenomegaly. Recent studies have demonstrated that hematopoetic cells can influence the differentiation of osteogenic cells. Thus, we examined the skeletal phenotype of mice expressing the G233V variant complex. At 6 months of age, G233V mice exhibit a high bone mass phenotype with an approximate doubling of trabecular bone volume in both the tibia and femur. Serum measures of bone resorption were significantly decreased in G233V animals. With decreased bone resorption, cortical thickness was increased, medullary area decreased, and consequently, the mechanical strength of the femur was significantly increased. Using ex vivo bone marrow cultures, osteoclast-specific staining in the G233V mutant marrow was diminished, whereas osteoblastogenesis was unaffected. These studies provide new insights into the relationship between the regulation of megakaryocytopoiesis and bone mass. PMID:18187573

MSFC Director welcomes attendees to the 10th Annual Wernher von

NASA Image and Video Library

2017-10-26

Marshall Space Flight Center director Todd May welcomes attendees to the 10th annual Dr. Wernher von Braun Memorial Symposium held at the University of Alabama, Huntsville, Alabama. The three-day symposium brought together experts for discussion panels on science, engineering and technology under the theme “Gateways in Space: Exploration, Security, and Commerce.”

Einheit von Forschung und Lehre: Implications for State Funding of Universities

ERIC Educational Resources Information Center

Frolich, Nicoline; Coate, Kelly; Mignot-Gerard, Stephanie; Knill, Christoph

2010-01-01

The Humboldtian educational ideal is based on the idea of the unity of teaching and research in universities ("Einheit von Forschung und Lehre"). The role of the state, according to Humboldt, was to fund universities in such a way that their autonomy was maintained. Much has changed in the funding mechanisms of higher education systems…

Personality as a Social Process: where Peter Giordano Meets Boris Parygin.

PubMed

Mironenko, Irina A

2018-06-01

In this paper I comment on the "Individual personality is best understood as process, not structure: A Confucian-inspired perspective" article by Peter Giordano (Culture & Psychology, 23(4), 502-518 (2017)), which addresses the question of how to comprehend a personality which is continuously changing and varying with changes in social contexts and situations. The issue which Giordano turns up I believe to be of great importance and topicality in the quickly changing globalizing contemporary world. Giordano's paper highlights an important problem in the development of contemporary personality psychology, but much remains to be clarified concerning his process-centric model. I introduce the theory of Boris Parygin, which can make a contribution to the discussion of personality as a process. Parygin's theory addresses the same issues that Giordano focuses on: human personality exists and develops in the context of social situation. Parygin's theoretical model of personality involves two personality schemas: a "static" one and a "dynamic" one. The "structure" and the "process" -centered approaches are joint here to complement each other. Personality life-span development, formation of personality structures, is considered as a process of interaction and dialectical confrontation with the social environment, in the course of which the personality, originally engendered by social factors, builds up its autonomy and realizes its unique individual spiritual potential.

L'atteinte vésicale au cours de la neurofibromatose de Von Recklinghausen

PubMed Central

Benazzouz, Mohamed Hicham; Hajjad, Tilila; Essatara, Younes; El Sayegh, Hachem; Iken, Ali; Benslimane, Lounis; Nouini, Yassine

2014-01-01

La neurofibromatose de type 1 ou maladie de Von Recklinghausen est une maladie génétique autosomique dominante en rapport avec des mutations dans le gène suppresseur de tumeur NF1. L'atteinte uro-génitale au cours de cette maladie est rare et moins de 80 cas ont été rapportés à ce jour dans la littérature mondiale. Les auteurs rapportent un nouveau cas d'atteinte vésicale découverte fortuitement au cours du suivi d'une patiente atteinte de la maladie de Von Recklinghausen. A travers cette observation et une revue de la littérature les auteurs discutent également les difficultés diagnostiques, thérapeutiques ainsi que les modalités de suivi dans cette maladie. PMID:25328590

Galerkin analysis of kinematic dynamos in the von Kármán geometry

NASA Astrophysics Data System (ADS)

Marié, L.; Normand, C.; Daviaud, F.

2006-01-01

We investigate dynamo action by solving the kinematic dynamo problem for velocity fields of the von Kármán type between two coaxial counter-rotating propellers in a cylinder. A Galerkin method is implemented that takes advantage of the symmetries of the flow and their subsequent influence on the nature of the magnetic field at the dynamo threshold. Distinct modes of instability have been identified that differ by their spatial and temporal behaviors. Our calculations give the result that a stationary and antisymmetric mode prevails at the dynamo threshold. We then present a quantitative analysis of the results based on the parametric study of four interaction coefficients obtained by reduction of our initially large eigenvalue problem. We propose these coefficients to measure the relative importance of the different mechanisms at play in the von Kármán kinematic dynamo.

Quantitative conditions for time evolution in terms of the von Neumann equation

NASA Astrophysics Data System (ADS)

Wang, WenHua; Cao, HuaiXin; Chen, ZhengLi; Wang, Lie

2018-07-01

The adiabatic theorem describes the time evolution of the pure state and gives an adiabatic approximate solution to the Schödinger equation by choosing a single eigenstate of the Hamiltonian as the initial state. In quantum systems, states are divided into pure states (unite vectors) and mixed states (density matrices, i.e., positive operators with trace one). Accordingly, mixed states have their own corresponding time evolution, which is described by the von Neumann equation. In this paper, we discuss the quantitative conditions for the time evolution of mixed states in terms of the von Neumann equation. First, we introduce the definitions for uniformly slowly evolving and δ-uniformly slowly evolving with respect to mixed states, then we present a necessary and sufficient condition for the Hamiltonian of the system to be uniformly slowly evolving and we obtain some upper bounds for the adiabatic approximate error. Lastly, we illustrate our results in an example.

Estimating age at a specified length from the von Bertalanffy growth function

USGS Publications Warehouse

Ogle, Derek H.; Isermann, Daniel A.

2017-01-01

Estimating the time required (i.e., age) for fish in a population to reach a specific length (e.g., legal harvest length) is useful for understanding population dynamics and simulating the potential effects of length-based harvest regulations. The age at which a population reaches a specific mean length is typically estimated by fitting a von Bertalanffy growth function to length-at-age data and then rearranging the best-fit equation to solve for age at the specified length. This process precludes the use of standard frequentist methods to compute confidence intervals and compare estimates of age at the specified length among populations. We provide a parameterization of the von Bertalanffy growth function that has age at a specified length as a parameter. With this parameterization, age at a specified length is directly estimated, and standard methods can be used to construct confidence intervals and make among-group comparisons for this parameter. We demonstrate use of the new parameterization with two data sets.

von Neumann's Law: Theoretical and Microgravity Experimental Comparison for Coarsening Diffusion in Bubble Lattices

NASA Technical Reports Server (NTRS)

Noever, David A.

2000-01-01

The effects of gravity in influencing the theoretical limit for bubble lattice coarsening and aging behavior, otherwise called von Neumann's law, is examined theoretically and experimentally. Preliminary microgravity results will be discussed.

Detailed von Willebrand factor multimer analysis in patients with von Willebrand disease in the European study, molecular and clinical markers for the diagnosis and management of type 1 von Willebrand disease (MCMDM-1VWD).

PubMed

Budde, U; Schneppenheim, R; Eikenboom, J; Goodeve, A; Will, K; Drewke, E; Castaman, G; Rodeghiero, F; Federici, A B; Batlle, J; Pérez, A; Meyer, D; Mazurier, C; Goudemand, J; Ingerslev, J; Habart, D; Vorlova, Z; Holmberg, L; Lethagen, S; Pasi, J; Hill, F; Peake, I

2008-05-01

Type 1 von Willebrand disease (VWD) is a congenital bleeding disorder characterized by a partial quantitative deficiency of plasma von Willebrand factor (VWF) in the absence of structural and/or functional VWF defects. Accurate assessment of the quantity and quality of plasma VWF is difficult but is a prerequisite for correct classification. To evaluate the proportion of misclassification of patients historically diagnosed with type 1 VWD using detailed analysis of the VWF multimer structure. Previously diagnosed type 1 VWD families and healthy controls were recruited by 12 expert centers in nine European countries. Phenotypic characterization comprised plasma VWF parameters and multimer analysis using low- and intermediate-resolution gels combined with an optimized visualization system. VWF genotyping was performed in all index cases (ICs). Abnormal multimers were present in 57 out of 150 ICs; however, only 29 out of these 57 (51%) had VWF ristocetin cofactor to antigen ratio below 0.7. In most cases multimer abnormalities were subtle, and only two cases had a significant loss of the largest multimers. Of the cases previously diagnosed as type 1 VWD, 38% showed abnormal multimers. Depending on the classification criteria used, 22 out of these 57 cases (15% of the total cohort) may be reclassified as type 2, emphasizing the requirement for multimer analysis compared with a mere ratio of VWF functional parameters and VWF:Ag. This is further supported by the finding that even slightly aberrant multimers are highly predictive for the presence of VWF mutations.

Analysis of nuclear accumulation of influenza NP antigen in von Magnus virus-infected cells.

PubMed

Maeno, K; Aoki, H; Hamaguchi, M; Iinuma, M; Nagai, Y; Matsumoto, T; Takeura, S; Shibata, M

1981-01-01

When 1-5C-4 cells were infected with von Magnus virus derived from influenza A/RI/5+ virus by successive undiluted passages in chick embryos, virus-specific proteins were synthesized but production of infectious virus was inhibited. In these cells the synthesis of viral RNA was suppressed and the nucleoprotein (NP) antigen was found predominantly in the nucleus in contrast to standard virus-infected cells in which the antigen was distributed throughout the whole cell. The intracellular location and migration of NP were determined by isotope labeling and sucrose gradient centrifugation of subcellular fractions. In standard virus-infected cell NP polypeptide was present predominantly in the cytoplasm in the form of viral ribonucleoprotein (RNP) and intranuclear RNP was detected in reduced amounts. In contrast, in von Magnus virus-infected cells NP polypeptide was present predominantly in the nucleus in a nonassembled, soluble from and the amount of cytoplasmic RNP was considerably reduced. After short-pulse labeling NP was detected exclusively in the cytoplasm in a soluble form and after a chase a large proportion of such soluble NP was seen in the nucleus. It is suggested that a large proportion of the NP synthesized in von Magnus virus-infected cells in not assembled into cytoplasmic RNP because of the lack of available RNA and the NP migrated into the nucleus and remained there.

How Alexander von Humboldt's life story can inspire innovative soil research in developing countries

NASA Astrophysics Data System (ADS)

Bouma, Johan

2017-09-01

The pioneering vision of Alexander von Humboldt of science and society of the early 1800s is still highly relevant today. His open mind and urge to make many measurements characterizing the interconnected web of life are crucial ingredients as we now face the worldwide challenge of the UN Sustainable Development Goals. Case studies in the Philippines, Vietnam, Kenya, Niger, and Costa Rica demonstrate, in Alexander's spirit, interaction with stakeholders and attention to unique local conditions, applying modern measurement and modeling methods and allowing inter- and transdisciplinary research approaches. But relations between science and society are increasingly problematic, partly as a result of the information revolution and post-truth, fact-free thinking. Overly regulated and financially restricted scientific communities in so-called developed countries may stifle intellectual creativity. Researchers in developing countries are urged to leapfrog these problems in the spirit of Alexander von Humboldt as they further develop their scientific communities. Six suggestions to the science community are made with particular attention to soil science. (The Humboldt lecture, presented by the 2017 recipient of the Alexander von Humboldt lecture, Johan Bouma, can be accessed at http://client.cntv.at/egu2017/ml1.)

Critical assessment of von Mises distribution and an infinite series ansatz for self-propelled particles

NASA Astrophysics Data System (ADS)

Kürsten, Rüdiger; Ihle, Thomas

2017-03-01

We consider a Vicsek model of self-propelled particles with bounded confidence, where each particle interacts only with neighbors that have a similar direction. Depending on parameters, the system exhibits a continuous or discontinuous polar phase transition from the isotropic phase to a phase with a preferred direction. In a recent paper (Lam, Schindler and Dauchot 2015 J. Stat. Mech. P10017) the von Mises distribution was proposed as an ansatz for polar ordering. In the present system the time evolution of the angular distribution can be solved in Fourier space. We compare the results of the Fourier analysis with the ones obtained by using the von Mises distribution ansatz. In the latter case the qualitative behavior of the system is recovered correctly. However, quantitatively there are serious deviations. We introduce an extended von Mises distribution ansatz such that a second term takes care of the next two Fourier modes. With the extended ansatz we find much better quantitative agreement. As an alternative approach we also use a Gaussian and a geometric series ansatz in Fourier space. The geometric series ansatz is analytically handable but fails for very weak noise, the Gaussian ansatz yields better results but it is not analytically treatable.

Prognostischer Wert der Fläche und Dichte von Lymphgefäßen bei kutanem Plattenepithelkarzinom.

PubMed

Krediet, Jorien Tannette; Kanitakis, Jean; Bob, Adrienne; Schmitter, Julia; Carine Krediet, Annelot; Röwert, Joachim; Stockfleth, Eggert; Painsi, Clemens; Hügel, Rainer; Terhorst, Dorothea; Lange-Asschenfeldt, Bernhard

2016-11-01

Kutane Plattenepithelkarzinome (SCC) sind bekannt für ihre Fähigkeit, über Lymphgefäße zu metastasieren. In neueren Studien wird das Ausmaß der Lymphangiogenese als möglicher prognostischer Faktor bei einigen Hauttumoren genannt. Ziel dieser Studie war die Quantifizierung der Lymphangiogenese bei SCC entweder durch computergestützte Bildanalyse oder mithilfe der Zählmethode nach Chalkley. Gefäßparameter wurden im Hinblick auf ihre Vorhersagekraft für die Bildung von Tumormetastasen beurteilt und verglichen. In dieser Fallkontrollstudie wurden die klinischen und histologischen Daten von jeweils 15 SCC-Patienten mit bzw. ohne Metastasen retrospektiv analysiert. In den SCC-Proben wurde der für das Lymphendothel spezifische Marker D2-40 und der pan-vaskuläre Marker CD31 immunhistochemisch angefärbt und durch computergestützte morphometrische Bildanalyse in Hotspots sowie mithilfe der digitalisierten Zählmethode nach Chalkley analysiert. Die Dichte von Lymphgefäßen, die relative Lymphgefäßfläche und die mit der Chalkley-Methode ermittelte Zahl an Lymphgefäßen (Chalkley-Count) waren bei metastasierten SCC signifikant erhöht. Die Tumordicke war bei metastasierten SCC signifikant höher und besaß die höchste Vorhersagekraft für eine Metastasierung. Die Tumordicke war ein signifikanter Prädiktor für Lymphangiogeneseparameter. Die Lymphangiogenese ist bei metastasierten SCC erhöht, doch ihr Ausmaß wird von der Tumordicke beeinflusst. Die Tumordicke bildet weiterhin den zuverlässigsten prädiktiven Faktor für die Metastasierung. © 2016 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.

A visit paid to Jung by Alwine von Keller.

PubMed

Bernardini, Riccardo; Quaglino, Gian Piero; Romano, Augusto

2011-04-01

In the winter of 1943-1944, Jung had suffered a coronary thrombosis which almost cost him his life. During his illness, Jung experienced a series of visions, described in his Memories, Dreams, Reflections, which were also to influence significantly the development of his theoretical thinking. On 27(th) September 1944, Alwine von Keller (1878-1965) paid a visit to Jung, while he was still convalescing, in Zurich and documented her meeting with him in a series of notes, recently discovered, which testify to the fact that, at the time of their meeting, Jung was engaged in writing the 'Salt' chapter of Mysterium coniunctionis and investigating the alchemistic symbolism of the 'sea'. This theme seems to testify to a continuity of interests on Jung's part with the seminar he held at Eranos the previous year on the cartographic art of Opicinus de Canistris (1296-c.1352). With its addition of many unpublished details, Alwine von Keller's notes supplement the report which Jung made of his visions experienced during his sickness in MDR. In particular, these attest to the fact that Jung had attributed the terrible experience which he had endured to the problem of the conjunctio, which was confronting him from the theoretical point of view in his writing of Mysterium coniunctionis. © 2011, The Society of Analytical Psychology.

The (re)-introduction of semiotics into medical education: on the works of Thure von Uexküll.

PubMed

Tredinnick-Rowe, John

2017-03-01

Thure von Uexküll's reputation as a pioneer in biosemiotics and also in psychosomatic medicine is well documented. It is easy to see these disciplines reflected in his notable publications, both in English and in German. However, if one spares the time to filter through all of his articles, monographs, conference papers and editorials in English and in German, a notable gap arises in his English language publications: that of clinical education. This gap in the English language literature may seem unimportant in and of itself, but it speaks volumes when we consider the total absence of medical semiotics in the curriculum of medical schools in the English speaking world. This runs in stark contrast to the strong traditions of psychosomatic medicine in Germany, which Thure von Uexküll largely helped to instil. Do the works of Thure von Uexküll offer a possible step towards a resurrection of medical semiotics in clinical education? This chapter attempts to explore the lesser known German literature on clinical education that Thure von Uexküll produced, and explore the role semiotics can play in Medical Education in the English speaking world. While also seeking to contrast this literature with other existing approaches in British and American medical schools who have attempted to reintroduce medical humanities and reflexive thinking into clinical education. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Hemophilia and von Willebrand's disease: 2. Management. Association of Hemophilia Clinic Directors of Canada.

PubMed Central

1995-01-01

OBJECTIVE: To present current strategies for the treatment of hemophilia and von Willebrand's disease. OPTIONS: Prophylactic and corrective therapy with hemostatic and adjunctive agents: DDAVP (1-desamino-8-D-arginine vasopressin [desmopressin acetate]), recombinant coagulation products (human Factor VIII and human Factor VIIa) or virally inactivated plasma-derived products (high- or ultra-high-purity human Factor VIII or human Factor VIII concentrate containing von Willebrand factor activity, porcine Factor VIII, high-purity human Factor IX, human prothrombin-complex concentrate, human activated prothrombin-complex concentrate), adjunctive antifibrinolytic agents, topical thrombin and fibrin sealant. The induction of immune tolerance in patients in whom inhibitors develop should also be considered. OUTCOMES: Morbidity and quality of life associated with bleeding and treatment. EVIDENCE: Relevant clinical studies and reports published from 1974 to 1994 were examined. A search was conducted of our reprint files, MEDLINE, citations in the articles reviewed and references provided by colleagues. In the MEDLINE search the following terms were used singly or in combination: "hemophilia," "von Willebrand's disease," "Factor VIII," "Factor IX," "von Willebrand factor," "diagnosis," "management," "home care," "comprehensive care," "inhibitor," "AIDS," "hepatitis," "life expectancy," "complications," "practice guidelines," "consensus statement" and "controlled trial." The in-depth review included only articles written in English from North America and Europe that were relevant to human disease and pertinent to a predetermined outline. The availability of treatment products in Canada was also considered. VALUES: Minimizing morbidity and maximizing functional status and quality of life were given a high value. BENEFITS, HARMS AND COSTS: Proper prophylactic or early treatment with appropriate hemostatic agents minimizes morbidity and functional disability and improves quality

Cancer: A Personal Journey. Notes from the Edge.The Diary of Peter J. Morgan, M.D.

PubMed

Chabner

1997-01-01

It is a mistake to think that all personal experiences with cancer are the same. For certain, all cancer patients do confront the possibility of an early death and the prospect of pain and suffering due to the tumor and its treatment. But the specific emotional issues differ with each patient and each family, and the responses to these issues take many forms. In an eloquent and moving film, "Cancer: A Personal Journey. Notes from the Edge.," we are given the privilege of accompanying a remarkable young physician, Peter J. Morgan, on his journey with cancer, a two and one-half year journey that ended with his death at age 31. At age 29, Dr. Morgan, an internist-in-training who intended to pursue a career in hematology and oncology, noted a mass on his leg. Tragically, metastasis to the lungs had already taken place at the time of diagnosis of a synovial sarcoma. There followed the all-too-familiar story of chemotherapy and experimental treatments, pain, debilitation, and ultimately demise, and in itself this experience would move us with the sorrow of a precious life lost. What makes this particular story so remarkable are the insights of this young physician and the struggle for survival of a spirit that would not succumb to the "chaos" of cancer. In the two-year period of his life as a cancer patient, Peter Morgan kept a diary that records his thoughts, his emotional turmoil, and his reflections on life and an untimely death. In particular, we are able to understand the need for his spiritual self to remain alive and to grow despite the deterioration of his physical being. And we see that spiritual triumph in his compelling relationships with his family and his colleagues, in his reflections on art and music and nature, and most of all in his writings and his appreciation of the immense possibilities for joy in life. This is not an easy journey to watch, but the intense sadness of his experience is balanced by his friendships and the great satisfaction he derived

Werner von Braun relaxes after successful Apollo 11 Saturn V launch

NASA Technical Reports Server (NTRS)

1969-01-01

Dr. Wernher von Braun, director of the Marshall Space Flight Center, Huntsville, Alabama, relaxes after the successful launch of Apollo 11 astronauts Neil A. Armstrong, Michael Collins and Edwin Aldrin Jr. today. Their historic lunar landing mission began at 9:32 a.m. EDT, July 16, 1969, when an Apollo/Saturn V space vehicle lifted off from the spaceport's Launch Complex 39A.

Dr. von Braun Relaxes After the Successful Launch of Apollo 11

NASA Technical Reports Server (NTRS)

1969-01-01

Dr. Wernher von Braun, first director of the Marshall Space Flight Center, relaxes following the successful launch of the Saturn V carrying Apollo 11 to the moon. The towering 363-foot Saturn V was a multi-stage, multi-engine launch vehicle standing taller than the Statue of Liberty. Altogether, the Saturn V engines produced as much power as 85 Hoover Dams.

Brachymesomelic dysplasia with Peters anomaly of the eye results from disruptions of the X chromosome near the SHOX and SOX3 genes.

PubMed

Bleyl, Steven B; Byrne, Janice L B; South, Sarah T; Dries, David C; Stevenson, David A; Rope, Alan F; Vianna-Morgante, Angela M; Schoenwolf, Gary C; Kivlin, Jane D; Brothman, Arthur; Carey, John C

2007-12-01

We report on a mother and son affected with an unusual skeletal dysplasia and anterior segment eye abnormalities. Their skeletal phenotype overlaps with the SHOX-related skeletal dysplasias and is intermediate between Leri-Weill dyschondrosteosis (LWD) and Langer Mesomelic dysplasia (LMD). The mother has bilateral Peters anomaly of the eye and was reported as having a new syndrome; the son had severe bilateral sclerocornea. Chromosome analysis showed that the mother has a pericentric inversion of the X chromosome [46,X,inv(X)(p22.3q27)] and the son, a resultant recombinant X chromosome [46,Y,rec(X)dup(Xq)inv(X)(p22.3q27)]. The observed skeletal and ophthalmologic abnormalities in both patients were similar in severity. The additional features of developmental delay, growth retardation, agenesis of the corpus callosum, cryptorchidism and hypoplastic scrotum in the son are consistent with Xq28 duplication. Analysis of the son's recombinant X chromosome showed that the Xp22.33 breakpoint lies 30-68 kb 5' of the SHOX gene. This finding suggests that the skeletal dysplasia in both mother and son is allelic with LWD and LMD and results from a novel misexpression of SHOX. Analysis of the Xq27.1 breakpoint localized it to a 90 kb interval 3' of the SOX3 gene, supporting a novel role of SOX3 misexpression in the development of Peters anomaly of the eye. (c) 2007 Wiley-Liss, Inc.

AVTA Federal Fleet PEV Readiness Data Logging and Characterization Study for Department of Veterans Affairs. James J. Peters VA Medical Center, Bronx, NY

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schey, Stephen; Francfort, Jim

This report focuses on the Department of Veterans Affairs, James J. Peters VA Medical Center (VA - Bronx) fleet to identify daily operational characteristics of select vehicles and report findings on vehicle and mission characterizations to support the successful introduction of PEVs into the agencies’ fleets. Individual observations of these selected vehicles provide the basis for recommendations related to electric vehicle adoption and whether a battery electric vehicle or plug-in hybrid electric vehicle (collectively referred to as PEVs) can fulfill the mission requirements.

Displacements Of Brownian Particles In Terms Of Marian Von Smoluchowski's Heuristic Model

ERIC Educational Resources Information Center

Klein, Hermann; Woermann, Dietrich

2005-01-01

Albert Einstein's theory of the Brownian motion, Marian von Smoluchowski's heuristic model, and Perrin's experimental results helped to bring the concept of molecules from a state of being a useful hypothesis in chemistry to objects existing in reality. Central to the theory of Brownian motion is the relation between mean particle displacement and…

Otto von Guericke and 17th century cosmology

NASA Astrophysics Data System (ADS)

Knobloch, Eberhard

Otto von Guericke's scientific method was based on reason and experimental science. His cosmology was embedded in theology and can be interpreted as a refutation of Descartes' worldview. He used Nicolaus Cusanus' theory of quantities in order to characterize space. The notion of space has to be distinguished from that of world or heaven. Forces play a crucial role in this respect described by Athanasius Kircher in his "Celestial Journey". Guericke read this work very diligently. In spite of some obvious similarities between Guericke's and Newton's scientific aims and methods there are crucial differences between the scientific convictions and results of these scholars.

Kamera-basierte Erkennung von Geschwindigkeitsbeschränkungen auf deutschen Straen

NASA Astrophysics Data System (ADS)

Nienhüser, Dennis; Ziegenmeyer, Marco; Gumpp, Thomas; Scholl, Kay-Ulrich; Zöllner, J. Marius; Dillmann, Rüdiger

An Fahrerassistenzsysteme im industriellen Einsatz werden hohe Anforderungen bezüglich Zuverlässigkeit und Robustheit gestellt. In dieser Arbeit wird die Kombination robuster Verfahren wie der Hough-Transformation und Support-Vektor-Maschinen zu einem Gesamtsystem zur Erkennung von Geschwindigkeitsbeschränkungen beschrieben. Es setzt eine Farbvideokamera als Sensorik ein. Die Evaluation auf Testdaten bestätigt durch die ermittelte hohe Korrektklassifikationsrate bei gleichzeitig geringer Zahl Fehlalarme die Zuverlässigkeit des Systems.

Earliest depiction of vitiligo in "Venus at a Mirror" (1615) by Peter Paul Rubens (1577-1640).

PubMed

Ashrafian, Hutan

2018-06-01

The 1615 painting of Venus at a Mirror by Peter Paul Rubens is considered a powerful example of the Flemish Baroque movement. Recently it has been identified that the Venus character in the image has a goitre, however on studying the image further, I note dermato-pathology in another of the painting's main characters; the dark-skinned female typically described as the Venus' maidservant who clearly demonstrates patches of skin pigment loss on her face and neck with a concurrent streak of white hair. Together these suggest the underlying diagnosis of vitiligo. There is also a goitre in this individual suggesting thyroid disease. This new finding may offer additional insight into the historical epidemiology of disease in northern Europe but also offers further understanding of the method, origin, and pathological associations of this prominent painting from a genius artist. © 2017 Wiley Periodicals, Inc.

New U.N. program promotes multisectoral approach to AIDS prevention. Q and A [with Peter Piot].

PubMed

1996-05-01

The new joint United Nations (UN) Program on HIV/AIDS (UNAIDS) coordinates the HIV/AIDS activities of its six co-sponsors: the UN Children's Fund (UNICEF), the UN Development Program (UNDP), the UN Population Fund (UNFPA), the UN Educational, Scientific, and Cultural Organization (UNESCO), the World Health Organization (WHO), and the World Bank. In this interview, UNAIDS Executive Director Peter Piot discusses the program's goals and challenges. The UNAIDS program will be more multisectoral in scope than other efforts, involving all sectors of society that can affect the course of the epidemic or are affected by it. This includes the health and education sectors; ministries of trade, finance, planning, and development; nongovernmental and community organizations; people living with HIV and AIDS; research institutions; and the business sector. In each country, the UN agencies will form a "Theme Group on HIV/AIDS" to formulate intersectoral strategies.

IR studies of the impact of Ge doping on the successive conversion of VOn defects in Czochralski-Si containing carbon

NASA Astrophysics Data System (ADS)

Londos, C. A.; Andrianakis, A.; Sgourou, E. N.; Emtsev, V. V.; Ohyama, H.

2011-02-01

We report infrared absorption studies of oxygen-related defects in electron-irradiated Ge-doped Czochralski-Si. Our investigation was mainly focused on the reaction channel leading to the formation of VOn (1≤n≤6) defects. The VOn defects form mainly upon annealing, as a result of the successive aggregation of oxygen atoms in the initial VO defect produced by the irradiation: (VO+Oi→VO2+Oi→VO3+Oi→VO4,…). It was found that the ratio of the conversion of VOn to VOn+1 defects is sensitive to the Ge content of the material. In particular, the ratio of the conversion of the VO to the VO2 defects was found to decrease with the increase in Ge concentration of the samples, although the opposite trend was observed for the VO3 to VO4 conversion. However, the VO2 to VO3 conversion changes only slightly with Ge content, being practically unaffected for Ge concentrations up to 2×1020 cm-3. In the case of VO2 formation, the phenomenon was attributed to the elastic strains induced in the lattice due to the Ge presence which affects the balance between the reactions VO+Oi→VO2, VO+SiI→Oi, mainly involved in the decay of the VO and the growth of the VO2 defects. In the case of VO4 formation, the phenomenon was discussed by taking into account the enhancement of the diffusivity of the Oi atoms in the Ge-doped Si, which could lead to an enhancement of the rate of the reaction VO3+Oi→VO4. For the VO3 formation this effect is practically negligible due to the fact that at the temperatures of VO2 to VO3 conversion oxygen diffusivity is quite small. The exhibited behavior in the conversion of the VOn to VOn+1 defects (n=1,2,3) was similar in Ge-doped samples with low carbon content ([Cs]<2×1016 cm-3) and in Ge-doped samples with high carbon content ([Cs]≥1×1017 cm-3). The impact of C as well as its role in the conversion efficiency of VO to VO2 was studied by comparing the spectra in low carbon and high carbon Ge free Si material. Furthermore, a pair of bands at

Citizenship Ceremony for Dr. von Braun and German-Born Scientists and Engineers

NASA Technical Reports Server (NTRS)

1955-01-01

In a swearing-in ceremony held at Huntsville High School, one hundred and three German-born scientists and engineers, along with family members, took the oath of citizenship to become United States citizens. Among those taking the oath was Dr. Wernher von Braun, located in the second row, right side, third from the end.

Identification of Langmuir wave turbulence-supercontinuum transition by application of von Neumann entropy

NASA Astrophysics Data System (ADS)

Kawamori, Eiichirou

2017-09-01

A transition from Langmuir wave turbulence (LWT) to coherent Langmuir wave supercontinuum (LWSC) is identified in one-dimensional particle-in-cell simulations as the emergence of a broad frequency band showing significant temporal coherence of a wave field accompanied by a decrease in the von Neumann entropy of classical wave fields. The concept of the von Neumann entropy is utilized for evaluation of the phase-randomizing degree of the classical wave fields, together with introduction of the density matrix of the wave fields. The transition from LWT to LWSC takes place when the energy per one plasmon (one wave quantum) exceeds a certain threshold. The coherent nature, which Langmuir wave systems acquire through the transition, is created by four wave mixings of the plasmons. The emergence of temporal coherence and the decrease in the phase randomization are considered as the development of long-range order and spontaneous symmetry breaking, respectively, indicating that the LWT-LWSC transition is a second order phase transition phenomenon.

The astronomer of the duchess -- Life and work of Franz Xaver von Zach 1754-1832. (German Title: Der Astronom der Herzogin -- Leben und Werk von Franz Xaver von Zach 1754-1832)

NASA Astrophysics Data System (ADS)

Brosche, Peter

The astronomer, geodesist, geographer and historian of science Franz Xaver von Zach (1754-1832) lived and worked in several European countries. Duke Ernst II of Saxe-Gotha-Altenburg appointed him as the founding scientist of his Seeberg Observatory. This was the place of his strongest activity. Why should we have an interest in him today? There is a rational and an emotional answer. First, he has rendered organisational services to his sciences which are equivalent to a great scientific achievement. Second, Zach was a very colourful character, travelled across many states in a time of radical changes and had connections with many colleagues and public figures. Images from his life therefore provide outlooks, insights and relations.

Perfecting the Individual: Wilhelm von Humboldt's Concept of Anthropology, "Bildung" and Mimesis

ERIC Educational Resources Information Center

Wulf, Christoph

2003-01-01

In the works of Wilhelm von Humboldt education took on a new quality, focusing firmly on the importance of the individual. "Bildung" was to become the principal task with a view to preparing the individual for the requirements of future life. In this article, the author investigates two aspects relating to the "Bildung" of the individual. First,…

"The captain and canon" C. W. A. von Wahl (1760-1846) (German Title: "Der Hauptmann und Kanonikus" C. W. A. von Wahl (1760-1846) )

NASA Astrophysics Data System (ADS)

Brosche, Peter

Von Wahl was an active member of the group of independent scholars, who were working in the German states within Goethe's time, and who performed astrometric and geodetic observations and calculations. Here we present some cornerstones of his life; longer intervals of it took place in Allstedt south of the Harz and in Halberstadt. Small scientific assets have been preserved at the Universitäts-Sternwarte Bonn. Therein, a lecture on secular variations of the ecliptic is of singular nature.

[Carl Friedrich von Weizsäcker's philosophy of the mind].

PubMed

Lyre, Holger

2014-01-01

The paper deals with Carl Friedrich von Weizsäcker's position within the philosophy of mind. It turns out that Weizsäcker's ontology is based on an unorthodox conception both in the philosophy of physics and in the philosophy of mind. His quantum information theoretic reductionism is based on a subtle combination of atomism and holism, his philosophy of mind connected to this is a neutral monism, which proposes a bold intertwining of mind, matter, and space.

Entwicklung von umwelt- und naturschutzgerechten Verfahren der landwirtschaftlichen Landnutzung für das Biosphärenreservat Schorfheide-Chorin

NASA Astrophysics Data System (ADS)

Meyer-Aurich, Andreas

1999-11-01

Mit der vorliegenden Arbeit werden exemplarisch Chancen und Grenzen der Integration von Umwelt- und Naturschutz in Verfahren der ackerbaulichen Landnutzung aufgezeigt. Die Umsetzung von Zielen des Umwelt- und Naturschutzes in Verfahren der Landnutzung ist mit verschiedenen Schwierigkeiten verbunden. Diese liegen zum einen in der Konkretisierung der Ziele, um diese umsetzen zu können, zum anderen in vielfach unzulänglichem Wissen über den Zusammenhang zwischen unterschiedlichen Formen der Landnutzung und insbesondere den biotischen Naturschutzzielen. Zunächst wird die Problematik der Zielfestlegung und Konkretisierung erörtert. Das Umweltqualitätszielkonzept von Fürst et al. (1992) stellt einen Versuch dar, Ziele des Umwelt- und Naturschutzes zu konkretisieren. Dieses Konzept haben Heidt et al. (1997) auf einen Landschaftsausschnitt von ca. 6000 ha im Biosphärenreservat Schorfheide-Chorin im Nordosten Brandenburgs angewendet. Eine Auswahl der von Heidt et al. (1997) formulierten Umweltqualitätsziele bildet die Basis dieser Arbeit. Für die ausgewählten Umweltqualitätsziele wurden wesentliche Einflussfaktoren der Landnutzung identifiziert und ein Bewertungssystem entwickelt, mit dem die Auswirkungen von landwirtschaftlichen Anbauverfahren auf diese Umweltqualitätsziele abgebildet werden können. Die praktizierte Landnutzung von 20 Betrieben im Biosphärenreservat Schorfheide-Chorin wurde von 1994 bis 1997 hinsichtlich ihrer Auswirkungen auf die Umweltqualitätsziele analysiert. Die Analyse ergab ein sehr differenziertes Bild, das zum Teil Unterschiede in der Auswirkung auf die Umweltqualitätsziele für den Anbau einzelner Kulturen oder für bestimmte Betriebstypen zeigte. Es zeigte sich aber auch, dass es bei der Gestaltung des Anbaus einzelner Kulturarten große Unterschiede gab, die für Umweltqualitätsziele Bedeutung haben. Neben der Analyse der Landnutzung im Biosphärenreservat Schorfheide-Chorin wurde ein System entwickelt, mit dem die modellhafte

Microbial anaerobic methane cycling in the subseafloor at the Von Damm hydrothermal vent field, Mid-Cayman Rise

NASA Astrophysics Data System (ADS)

Huber, J. A.; Reveillaud, J. C.; Stepanauskas, R.; McDermott, J. M.; Sylva, S. P.; Seewald, J.

2013-12-01

The Mid-Cayman Rise (MCR) is Earth's deepest and slowest spreading mid-ocean ridge located in the western Caribbean. With an axial rift valley floor at a depth of ~4200-6500 m, it represents one of the deepest sections of ridge crest worldwide. In 2009, the world's deepest hydrothermal vents (Piccard at 4960 m) and an ultramafic-influenced system only 20 km away on top of an oceanic core complex (Von Damm at 2350 m) were discovered along the MCR. Each site is hosted in a distinct geologic setting with different thermal and chemical regimes. The Von Damm site is a particularly interesting location to examine chemolithoautotrophic subseafloor microbial communities due to the abundant hydrogen, methane, and organic compounds in the venting fluids. Here, we used a combination of stable isotope tracing, next-generation sequencing, and single cell techniques to determine the identity, activity, and genomic repertoire of subseafloor anaerobic archaea involved in methane cycling in hydrothermal fluids venting at the Von Damm site. Molecular sequencing of phylogenetic marker genes revealed the presence of diverse archaea that both generate and consume methane across a geochemical and thermal spectrum of vents. Stable isotope tracing experiments were used to detect biological utilization of formate and dissolved inorganic carbon, and methane generation at 70 °C under anaerobic conditions. Results indicate that methanogenesis with formate as a substrate is occurring at 70 °C at two Von Damm sites, Ginger Castle and the Main Orifice. The results are consistent with thermodynamic predictions for carbon speciation at the temperatures encountered at the ultramafic-hosted Von Damm, where formate is predicted to be thermodynamically stable, and may thus serve as a an important source of carbon. Diverse thermophilic methanogenic archaea belonging to the genera Methanothermococcus were detected at all vent sites with both 16S rRNA tag sequencing and single cell sorting. Other

Geological Carbon Sequestration Storage Resource Estimates for the Ordovician St. Peter Sandstone, Illinois and Michigan Basins, USA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barnes, David; Ellett, Kevin; Leetaru, Hannes

The Cambro-Ordovician strata of the Midwest of the United States is a primary target for potential geological storage of CO2 in deep saline formations. The objective of this project is to develop a comprehensive evaluation of the Cambro-Ordovician strata in the Illinois and Michigan Basins above the basal Mount Simon Sandstone since the Mount Simon is the subject of other investigations including a demonstration-scale injection at the Illinois Basin Decatur Project. The primary reservoir targets investigated in this study are the middle Ordovician St Peter Sandstone and the late Cambrian to early Ordovician Knox Group carbonates. The topic of thismore » report is a regional-scale evaluation of the geologic storage resource potential of the St Peter Sandstone in both the Illinois and Michigan Basins. Multiple deterministic-based approaches were used in conjunction with the probabilistic-based storage efficiency factors published in the DOE methodology to estimate the carbon storage resource of the formation. Extensive data sets of core analyses and wireline logs were compiled to develop the necessary inputs for volumetric calculations. Results demonstrate how the range in uncertainty of storage resource estimates varies as a function of data availability and quality, and the underlying assumptions used in the different approaches. In the simplest approach, storage resource estimates were calculated from mapping the gross thickness of the formation and applying a single estimate of the effective mean porosity of the formation. Results from this approach led to storage resource estimates ranging from 3.3 to 35.1 Gt in the Michigan Basin, and 1.0 to 11.0 Gt in the Illinois Basin at the P10 and P90 probability level, respectively. The second approach involved consideration of the diagenetic history of the formation throughout the two basins and used depth-dependent functions of porosity to derive a more realistic spatially variable model of porosity rather than

Clinical features and natural history of von Hippel-Lindau disease.

PubMed

Maher, E R; Yates, J R; Harries, R; Benjamin, C; Harris, R; Moore, A T; Ferguson-Smith, M A

1990-11-01

The clinical features, age at onset and survival of 152 patients with von Hippel-Lindau disease were studied. Mean age at onset was 26.3 years and 97 per cent of patients had presented by aged 60 years. Retinal angioma was the first manifestation in 65 patients (43 per cent), followed by cerebellar haemangioblastoma (n = 60, 39 per cent) and renal cell carcinoma (n = 15, 10 per cent). Overall, 89 patients (59 per cent) developed a cerebellar haemangioblastoma, 89 (59 per cent) a retinal angioma, 43 (28 per cent) renal cell carcinoma, 20 (13 per cent) spinal haemangioblastoma and 11 (7 per cent) a phaeochromocytoma. Renal, pancreatic and epididymal cysts were frequent findings but their exact incidence was not accurately assessed. Mean age at diagnosis of renal cell carcinoma (44.0 +/- 10.9 years) was significantly older than that for cerebellar haemangioblastoma (29.0 +/- 10.0 years) and retinal angioma (25.4 +/- 12.7 years). The probability of a patient with von Hippel-Lindan disease developing a cerebellar haemangioblastoma, retinal angioma or renal cell carcinoma by age 60 years was 0.84, 0.7 and 0.69, respectively. A comprehensive screening protocol for affected patients and at-risk relatives is presented, based on detailed analysis of age at onset data for each of the major complications. Median actuarial survival was 49 years, with renal cell carcinoma the leading cause of death.

Hydrogeology for land-use planning: the Peters Creek area, Municipality of Anchorage, Alaska

USGS Publications Warehouse

Brunett, Jilann O.; Lee, Michael

1983-01-01

Wells currently provide all water supplies in the area. Most wells obtain enough water for individual household needs from unconsolidated, principally glacial and glacioalluvial deposits. In some places, however, wells must be drilled into the underlying bedrock to obtain adequate supplies. It may be possible to develop small community supplies--for individual trailer courts or subdivisions--in areas where yields of 20 gallons per minute or greater are reported for private, domestic wells. Peters Creek is a potential source of surface-water supply, but it would have to be treated to remove glacial silt during summer months. The chemical quality of both ground water and surface water in the area in generally acceptable for most uses. Foundation and excavation conditions, the potential for water pollution from onsite disposal of wastewater through septic tank systems, and the suitability of specific areas for certain types of development may be affected by the following factors: wetlands and areas of shallow ground water underlie about 30 percent of the study area; landslope exceeds 20 percent in about a third of the area; areas of fine-grained, low-permeability sediments are present locally; bedrock is within 25 feet of the land surface in about a third of the area. (USGS)

Dr. von Braun In Front of a Display of Missiles

NASA Technical Reports Server (NTRS)

1960-01-01

In this photo, Director of the US Army Ballistic Missile Agency (ABMA) Development Operations Division, Dr. Wernher von Braun, is standing before a display of Army missiles celebrating ABMA's Fourth Open House. The missiles in the background include (left to right) a satellite on a Juno II shroud with a Nike Ajax pointing left in front of a Jupiter missile. The Lacrosse is in front of the Juno II. The Nike Hercules points skyward in front of the Juno II and the Redstone.

Transfusion medicine management for reconstructive spinal repair in a patient with von Willebrand's disease and a history of heavy surgical bleeding.

PubMed

Bolan, C D; Rick, M E; Polly, D W

2001-12-01

A case report of a multidisciplinary approach to a second reconstructive back surgery in a patient with von Willebrand's disease, flatback syndrome, and a history of heavy surgical bleeding is presented. To review the perioperative planning and assessment of hemostasis and transfusion medicine management, including administration of Humate P, a Factor VIII preparation with high von Willebrand factor content. Reconstructive spinal procedures may require significant transfusion support even in patients with normal preoperative hemostasis. In addition to the hemostatic problem caused by von Willebrand's disease, the reported patient requested minimal exposure to allogeneic blood products because of hepatitis C infection acquired from previous transfusions. The multidisciplinary team included the patient, hematologist, blood bank medical director, anesthesiologist, and operating surgeon. Preoperative assessment showed a Type 2A von Willebrand's disease variant. A careful planning process included a test infusion of desmopressin and extensive autologous donations of red cells, plasma, and platelets, which were collected before the procedure. Anterior and posterior spine fusions were performed during a 14-hour procedure. Hemostasis and clinical response were excellent. Humate P was administered perioperatively as assessed by the baseline Factor VIII and von Willebrand's disease levels, the plasma volume, the half-life of infused Humate P, and the anticipated risk and tolerance for bleeding. The estimated blood loss was 5 L. Replacement included 9 units of autologous red cells, 6 units of autologous plasma, 2 autologous plateletpheresis collections, a single allogeneic plateletpheresis product, and 17,000 units of Humate P administered over the perioperative period. Using a careful multidisciplinary approach, excellent hemostasis can be achieved with minimal exposure to untreated allogeneic blood products during aggressive spinal surgery in a patient with a clinically

Diagnosis and management of von Willebrand disease: a developing country perspective.

PubMed

Nair, Sukesh Chandran; Viswabandya, Auro; Srivastava, Alok

2011-07-01

Special challenges exist in the management of patients with von Willebrand disease (VWD) because of limitations in diagnostic facilities and therapeutic options. However, even within these limitations, it is possible to establish comprehensive services for this condition. Our data show that among 202 patients with VWD, 107 were type 3, 62 were type 1, and the others different categories of type 2. Basic tests such as bleeding time and activated partial thromboplastin time with factor (F)VIII coagulant are able to diagnose most of those with severe disease. We have been able to adapt the specific tests such as von Willebrand factor (VWF) ristocetin cofactor and VWF antigen from the tedious batched manual methods to cost-effective automated methods on advanced coagulometers. Discriminatory tests such as VWF collagen binding, VWF:FVIIIB, ristocetin-induced platelet agglutination (RIPA) are done in batches. Therapeutic options and for the treatment of bleeding include desmopressin, cryoprecipitate, and intermediate purity VWF-containing clotting factor concentrates. Tranexamic acid is also widely used as well as hormonal therapy for menorrhagia. We have also shown that modest doses of intermediate purity FVIII (Koate DVI; Talecris Biotherapeutics, Raleigh, NC, USA) at 35 IU/kg preoperatively and 10 to 20 IU/kg after that are sufficient for surgical hemostasis in these patients. © Thieme Medical Publishers.

XRF investigation on skeletal remains from King Peter III of Aragon (1239-1285 A.D.) and Queen Blanche of Anjou (1280-1310 A.D.)

NASA Astrophysics Data System (ADS)

Piga, Giampaolo; Brunetti, Antonio; Lasio, Barbara; Enzo, Stefano; Malgosa, Assumpció

2014-03-01

We conducted an X-Ray Fluorescence investigation on bone fragments belonging to King Peter III of Aragon and Queen Blanche of Anjou. The spectroscopic analysis was carried out in selected points of the bone fragments. Several transitional elements normally unexpected in the bone composition have been found at varying level of concentration. The presence of these elements was interpreted in relation to chemical treatments for mummification of bodies as well as to dietary habits, including tools used for cooking and for the consumption of food.

Wernher von Braun

NASA Image and Video Library

1969-07-01

This photograph depicts Dr. von Braun (at right, showing his back) and other NASA officials surveying the deep-sea research submarine "Ben Franklin." Named for American patriot and inventor Ben Franklin, who discovered the Gulf Steam, the 50-foot Ben Franklin was built between 1966 and 1968 in Switzerland for deep-ocean explorer Jacques Piccard and the Grumman Aircraft Engineering Corporation. The submersible made a famous 30-day drift dive off the East Coast of the United States and Canada in 1969 mapping the Gulf Stream's currents and sea life, and also made space exploration history by studying the behavior of aquanauts in a sealed, self-contained, self-sufficient capsule for NASA. On July 14, 1969, the Ben Franklin was towed to the high-velocity center of the Stream off the coast of Palm Beach, Florida. With a NASA observer on board, the sub descended to 1,000 feet off of Riviera Beach, Florida and drifted 1,400 miles north with the current for more than four weeks, reemerging near Maine. During the course of the dive, NASA conducted exhaustive analyses of virtually every aspect of onboard life. They measured sleep quality and patterns, sense of humor and behavioral shifts, physical reflexes, and the effects of a long-term routine on the crew. The submarine's record-shattering dive influenced the design of Apollo and Skylab missions and continued to guide NASA scientists as they devised future marned space-flight missions.

Wernher von Braun

NASA Image and Video Library

1969-07-01

This photograph depicts Dr. von Braun (fourth from far right) and other NASA officials surveying the deep-sea research submarine "Ben Franklin." Named for American patriot and inventor Ben Franklin, who discovered the Gulf Steam, the 50-foot Ben Franklin was built between 1966 and 1968 in Switzerland for deep-ocean explorer Jacques Piccard and the Grumman Aircraft Engineering Corporation. The submersible made a famous 30-day drift dive off the East Coast of the United States and Canada in 1969 mapping the Gulf Stream's currents and sea life, and also made space exploration history by studying the behavior of aquanauts in a sealed, self-contained, self-sufficient capsule for NASA. On July 14, 1969, the Ben Franklin was towed to the high-velocity center of the Stream off the coast of Palm Beach, Florida. With a NASA observer on board, the sub descended to 1,000 feet off of Riviera Beach, Florida and drifted 1,400 miles north with the current for more than four weeks, reemerging near Maine. During the course of the dive, NASA conducted exhaustive analyses of virtually every aspect of onboard life. They measured sleep quality and patterns, sense of humor and behavioral shifts, physical reflexes, and the effects of a long-term routine on the crew. The submarine's record-shattering dive influenced the design of Apollo and Skylab missions and continued to guide NASA scientists as they devised future marned space-flight missions.

Molecular and clinical profile of von Willebrand disease in Spain (PCM-EVW-ES): comprehensive genetic analysis by next-generation sequencing of 480 patients

PubMed Central

Borràs, Nina; Batlle, Javier; Pérez-Rodríguez, Almudena; López-Fernández, María Fernanda; Rodríguez-Trillo, Ángela; Lourés, Esther; Cid, Ana Rosa; Bonanad, Santiago; Cabrera, Noelia; Moret, Andrés; Parra, Rafael; Mingot-Castellano, María Eva; Balda, Ignacia; Altisent, Carme; Pérez-Montes, Rocío; Fisac, Rosa María; Iruín, Gemma; Herrero, Sonia; Soto, Inmaculada; de Rueda, Beatriz; Jiménez-Yuste, Víctor; Alonso, Nieves; Vilariño, Dolores; Arija, Olga; Campos, Rosa; Paloma, María José; Bermejo, Nuria; Berrueco, Rubén; Mateo, José; Arribalzaga, Karmele; Marco, Pascual; Palomo, Ángeles; Sarmiento, Lizheidy; Iñigo, Belén; Nieto, María del Mar; Vidal, Rosa; Martínez, María Paz; Aguinaco, Reyes; César, Jesús María; Ferreiro, María; García-Frade, Javier; Rodríguez-Huerta, Ana María; Cuesta, Jorge; Rodríguez-González, Ramón; García-Candel, Faustino; Cornudella, Rosa; Aguilar, Carlos; Vidal, Francisco; Corrales, Irene

2017-01-01

Molecular diagnosis of patients with von Willebrand disease is pending in most populations due to the complexity and high cost of conventional molecular analyses. The need for molecular and clinical characterization of von Willebrand disease in Spain prompted the creation of a multicenter project (PCM-EVW-ES) that resulted in the largest prospective cohort study of patients with all types of von Willebrand disease. Molecular analysis of relevant regions of the VWF, including intronic and promoter regions, was achieved in the 556 individuals recruited via the development of a simple, innovative, relatively low-cost protocol based on microfluidic technology and next-generation sequencing. A total of 704 variants (237 different) were identified along VWF, 155 of which had not been previously recorded in the international mutation database. The potential pathogenic effect of these variants was assessed by in silico analysis. Furthermore, four short tandem repeats were analyzed in order to evaluate the ancestral origin of recurrent mutations. The outcome of genetic analysis allowed for the reclassification of 110 patients, identification of 37 asymptomatic carriers (important for genetic counseling) and re-inclusion of 43 patients previously excluded by phenotyping results. In total, 480 patients were definitively diagnosed. Candidate mutations were identified in all patients except 13 type 1 von Willebrand disease, yielding a high genotype-phenotype correlation. Our data reinforce the capital importance and usefulness of genetics in von Willebrand disease diagnostics. The progressive implementation of molecular study as the first-line test for routine diagnosis of this condition will lead to increasingly more personalized and effective care for this patient population. PMID:28971901

["As we're not willing to hang and behead and not able to deport...". On Emil Kraepelin's influence on Franz von Liszt].

PubMed

Schmidt-Recla, A; Steinberg, H

2008-03-01

Emil Kraepelin started his scientific career with a pamphlet demanding complete restructure of German penal law. It is well known that Kraepelin was a recipient of Cesare Lombroso's theses on degeneration and atavism. Therefore his demand for a correctional law completely replacing penal law is easily understood. Still undiscussed however is the question of whether Kraepelin's brochure had a decisive effect on German criminal law, especially on the so-called Marburg Program of Franz von Liszt, still viewed as the first emergence of modern criminal law and policies in Germany. Examination of this shows that despite major theoretical faults, Kraepelin came to conclusions that correspond remarkably with von Liszt's. Special focus should be directed on the psychologist Wilhelm Wundt, who criticised Kraepelin's juridical attempt in a very kind yet fundamental way, and on the relationship that existed between Kraepelin and von Liszt.

Remission of recurrent gastrointestinal bleeding after septal reduction therapy in patients with hypertrophic obstructive cardiomyopathy-associated acquired von Willebrand syndrome.

PubMed

Blackshear, J L; Stark, M E; Agnew, R C; Moussa, I D; Safford, R E; Shapiro, B P; Waldo, O A; Chen, D

2015-02-01

Gastrointestinal hemorrhage is considered to be a severe complication of von Willebrand disease. The optimal therapy for acquired von Willebrand syndrome and severe gastrointestinal bleeding with hypertrophic cardiomyopathy is undefined. Seventy-seven patients (median age, 67 years; interquartile range [IQR], 56-75 years; 49% women) with hypertrophic cardiomyopathy underwent von Willebrand factor multimer testing and acquisition of bleeding history. Bleeding was detected in 27 (36%) (median age, 74 years; IQR 66-76 years; 74% women), 20 with gastrointestinal bleeding, including 11 women with transfusion dependence. In these 11 women, the median duration of transfusion dependency was 36 months (IQR 18-44 months), and the median number of transfusions required was 25 (IQR 20-38). Two patients had undergone bowel resection for bleeding, one of them twice. Seven patients showed angiodysplasia, and the remainder had no endoscopic lesion. Bleeding recurred after bowel surgery or endoscopic intervention and medical therapy for hypertrophic cardiomyopathy in 10 of 11 patients. Two patients had septal myectomy, and six patients underwent alcohol septal ablation. With the exception of one patient in whom a significant gradient persisted after septal ablation, after the periprocedural period, patients after septal reduction therapy remained free of recurrent bleeding and need for transfusions. Acquired von Willebrand syndrome is common in hypertrophic cardiomyopathy. Gastrointestinal bleeding often recurs after endoscopic therapy, but may be relieved by structural cardiac repair. © 2014 International Society on Thrombosis and Haemostasis.

Nonlocal modeling and buckling features of cracked nanobeams with von Karman nonlinearity

NASA Astrophysics Data System (ADS)

Akbarzadeh Khorshidi, Majid; Shaat, Mohamed; Abdelkefi, Abdessattar; Shariati, Mahmoud

2017-01-01

Buckling and postbuckling behaviors of cracked nanobeams made of single-crystalline nanomaterials are investigated. The nonlocal elasticity theory is used to model the nonlocal interatomic effects on the beam's performance accounting for the beam's axial stretching via von Karman nonlinear theory. The crack is then represented as torsional spring where the crack severity factor is derived accounting for the nonlocal features of the beam. By converting the beam into an equivalent infinite long plate with an edge crack subjected to a tensile stress at the far field, the crack energy release rate, intensity factor, and severity factor are derived according to the nonlocal elasticity theory. An analytical solution for the buckling and the postbuckling responses of cracked nonlocal nanobeams accounting for the beam axial stretching according to von Karman nonlinear theory of kinematics is derived. The impacts of the nonlocal parameter on the critical buckling loads and the static nonlinear postbuckling responses of cracked nonlocal nanobeams are studied. The results indicate that the buckling and postbuckling behaviors of cracked nanobeams are strongly affected by the crack location, crack depth, nonlocal parameter, and length-to-thickness ratio.

HL-10 on lakebed with Jerauld R. Gentry, Peter Hoag, John A. Manke, and Bill Dana

NASA Technical Reports Server (NTRS)

1969-01-01

The four principal HL-10 pilots are seen here with the lifting body aircraft. They are, left to right; Air Force Major Jerauld R. Gentry, Air Force test pilot Peter Hoag, and NASA pilots John A. Manke and Bill Dana. All are wearing the pressure suits needed for flying above 50,000 feet. The HL-10 was one of five heavyweight lifting-body designs flown at NASA's Flight Research Center (FRC--later Dryden Flight Research Center), Edwards, California, from July 1966 to November 1975 to study and validate the concept of safely maneuvering and landing a low lift-over-drag vehicle designed for reentry from space. Northrop Corporation built the HL-10 and M2-F2, the first two of the fleet of 'heavy' lifting bodies flown by the NASA Flight Research Center. The contract for construction of the HL-10 and the M2-F2 was $1.8 million. 'HL' stands for horizontal landing, and '10' refers to the tenth design studied by engineers at NASA's Langley Research Center, Hampton, Va. After delivery to NASA in January 1966, the HL-10 made its first flight on Dec. 22, 1966, with research pilot Bruce Peterson in the cockpit. Although an XLR-11 rocket engine was installed in the vehicle, the first 11 drop flights from the B-52 launch aircraft were powerless glide flights to assess handling qualities, stability, and control. In the end, the HL-10 was judged to be the best handling of the three original heavy-weight lifting bodies (M2-F2/F3, HL-10, X-24A). The HL-10 was flown 37 times during the lifting body research program and logged the highest altitude and fastest speed in the Lifting Body program. On Feb. 18, 1970, Air Force test pilot Peter Hoag piloted the HL-10 to Mach 1.86 (1,228 mph). Nine days later, NASA pilot Bill Dana flew the vehicle to 90,030 feet, which became the highest altitude reached in the program. Some new and different lessons were learned through the successful flight testing of the HL-10. These lessons, when combined with information from it's sister ship, the M2-F2/F3

Digitale Transformation, aber wie? - Von der Spielwiese zur Umsetzungsplanung

NASA Astrophysics Data System (ADS)

Kaiser, Thomas

Es besteht wohl kaum Anlass zur Annahme, dass die seit Jahrzehnten etablierten Markt- und Technologiestrukturen der Energiewirtschaft sich nicht in einem radikalen Ablöseprozess mit Gewinnern und Verlierern befinden. Aber Vorsicht - vordergründig bereits verloren erscheinende Geschäftsmodelle erfahren im Zuge der Digitalisierung einerseits noch intensiveren Wettbewerbsdruck, können aber andererseits von diesem "technologischen Jungbrunnen" profitieren, um verlorenes Terrain zurückzugewinnen. Im folgenden Kapitel wird ein Managementzyklus aufgezeigt, der in Anlehnung an die bereits erfolgreiche Implementierung digitaler R/Evolutionen anderer Branchen aufzeigt, wie die Geschäftsleitung systematisch kostenbewusst und zielorientiert die Digitalisierung umsetzen kann.

Nebenwirkungen von TNF-alpha-Inhibitoren am Hautorgan.

PubMed

Lindhaus, Claudia; Tittelbach, Jörg; Elsner, Peter

2017-03-01

TNF-alpha-Inhibitoren werden seit Anfang der 1990er Jahre erfolgreich zur Behandlung diverser immunvermittelter entzündlicher Erkrankungen eingesetzt. Inzwischen gibt es eine umfangreiche Datenlage bezüglich ihrer Sicherheit. Nebenwirkungen sind bezogen auf die Häufigkeit der Anwendung selten und meist nicht schwerwiegend. Zu den Nebenwirkungen am Hautorgan zählen lokale injektionsassoziierte Reaktionen, Infektionen, immunvermittelte Reaktionen sowie Neoplasien. Die häufigsten schwerwiegenden Nebenwirkungen sind infektiöser Natur. Mykobakterielle Infektionen, aber auch non-mykobakterielle Erreger, Viren und Pilze können potenziell letale, systemische Infektionen auslösen. Im Folgenden wird eine Übersicht über das gegenwärtige Wissen bezüglich der Nebenwirkungen von TNFα-Inhibitoren am Hautorgan gegeben. © 2017 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.

Study of types of some species of “Filaria” (Nematoda) parasites of small mammals described by von Linstow and Molin

PubMed Central

Guerrero, R.; Bain, O.

2011-01-01

Parasitic nematodes from the Berlin (ZMB) and Vienna (NMW) Museum collections referred to the genus Filaria Mueller, 1787 by von Linstow or Molin were studied. Three samples were in good condition and the specimens redescribed. Litomosa hepatica (von Linstow, 1897) n. comb., sample ZMB Vermes Entozoa 3368, from the megachiropteran Pteropus neohibernicus, Bismarck Archipelago, resembles L. maki Tibayrenc, Bain & Ramanchandran, 1979, from Pteropus vampyrus, in Malaysia, but the buccal capsule differs. Both species display particular morphological characters which differ from species of Litomosa parasitic in microchiropterans. The remaining material originates from Brazil. The spicule morphology of Litomosoides circularis (von Linstow, 1899) Chandler, 1931, sample ZMB Vermes Entozoa 1059 from Hesperomys spec. (= Holochilus brasiliensis), Porto Alegre, confirms that it belongs to the sigmodontis group; the microfilaria presents characters of the genus Litomosoides, e.g. body attenuated at both extremities and salient cephalic hook. Taxonomic discussions by others confirm that species of Litomosoides belonging to the sigmodontis group and described subsequently are distinct from L. circularis. Litomosoides serpicula (Molin, 1858) Guerrero, Martin, Gardner & Bain, 2002, is redescribed, sample NMW 6323 from the bat Phyllostoma spiculatum (= Sturnira lilium), Ypanema. It is very close to L. brasiliensis Almeida, 1936, type host Moytis sp., but distinguished by a single ring in the buccal capsule, rather than two, supporting previous conclusions that the taxon L. brasiliensis, as generally regarded, may represent a complex of species. Samples NMW 6322 and NMW 6324, from other bats and also identified by Molin (1858) as Filaria serpicula, contain unidentifiable fragments of Litomosoides incertae sedis. Filaria hyalina von Linstow, 1890, sample ZMB Vermes Entozoa Q 3905 from Sorex vulgaris (= Sorex araneus), is incertae sedis because it contains two unidentifiable posterior

Alexander von Humboldt's perceptions of colonial Spanish America.

PubMed

Rebok, Sandra

2009-01-01

This study presents an in-depth analysis of Alexander von Humboldt's descriptions and critical comments on the colonial society of the different regions he visited during his well-known expedition through the Americas (1799-1804). The criticisms of colonialism that he expressed, reflecting his personal convictions, have already been the focal point of many studies, but Humboldt also was able to offer a more differentiated assessment through comparisons of regional and local traditions and developments. This essay focuses on his personal diaries, which offer many interesting comments on colonial societies. These considerations and impressions made during the expedition are of particular scholarly value since they were not subject to censorship of any kind.

Symmetries and solutions of the non-autonomous von Bertalanffy equation

NASA Astrophysics Data System (ADS)

Edwards, Maureen P.; Anderssen, Robert S.

2015-05-01

For growth in a closed environment, which is indicative of the situation in laboratory experiments, autonomous ODE models do not necessarily capture the dynamics under investigation. The importance and impact of a closed environment arise when the question under examination relates, for example, to the number of the surviving microbes, such as in a study of the spoilage and contamination of food, the gene silencing activity of fungi or the production of a chemical compound by bacteria or fungi. Autonomous ODE models are inappropriate as they assume that only the current size of the population controls the growth-decay dynamics. This is reflected in the fact that, asymptotically, their solutions can only grow or decay monotonically or asymptote. Non-autonomous ODE models are not so constrained. A natural strategy for the choice of non-autonomous ODEs is to take appropriate autonomous ones and change them to be non-autonomous through the introduction of relevant non-autonomous terms. This is the approach in this paper with the focus being the von Bertalanffy equation. Since this equation has independent importance in relation to practical applications in growth modelling, it is natural to explore the deeper relationships between the introduced non-autonomous terms through a symmetry analysis, which is the purpose and goal of the current paper. Infinitesimals are derived which allow particular forms of the non-autonomous von Bertalanffy equation to be transformed into autonomous forms for which some new analytic solutions have been found.

Bleeding score in type 1 von Willebrand disease patients using the condensed MCMDM-1 vWD validated questionnaire.

PubMed

Pathare, A; Al Hajri, F; Al Omrani, S; Al Obaidani, N; Al Balushi, B; Al Falahi, K

2018-05-13

Assessment of the severity of bleeding symptom has led to the evolution of bleeding assessment tools which are now validated. To administer the condensed molecular and clinical markers for the diagnosis and management of type 1 von Willebrand disease VWD (MCMDM-1 vWD) questionnaire to the Omani type 1 vWD patients and correlate it with the laboratory parameters. Patients and controls were personally interviewed and the condensed MCMDM-1 vWD questionnaire administered by a single investigator. Bleeding score (BS) was calculated, based on the presence or absence of the bleeding symptoms according to a standard validated questionnaire in both the patients and the controls. The median age of the patient cohort was 27 (range, 7-49) years with 60.87% of females. The median time to administer condensed MCMDM-1 BS questionnaire was 11 minutes (interquartile range-IQR;7,16). Overall, bleeding from the oral cavity was the most predominant symptom (63%). The median BS was 5 (IQR;1,8) although individual scores ranged between 0 and 29. However, there was no statistically significant difference in BS between genders (males: median 4; IQR 1,6 and females: median 5, IQR 1,10) (P > .05, Kruskal-Wallis test) The Spearman's correlation value of BS was weak with FVIII:C levels and von Willebrand Ristocetin co-factor activity; very weak with von Willebrand Antigen level, and moderate with vonWillebrand Collagen Binding activity being -0.29, -0.28, -0.14 and -0.43, respectively. The BS reflects the severity of bleeding among the vWD patients. Although the BS was abnormal, it did not correlate significantly with the surrogate laboratory parameters [P > .05]. © 2018 John Wiley & Sons Ltd.

Of von Willebrand factor and platelets.

PubMed

Bryckaert, Marijke; Rosa, Jean-Philippe; Denis, Cécile V; Lenting, Peter J

2015-01-01

Hemostasis and pathological thrombus formation are dynamic processes that require multiple adhesive receptor-ligand interactions, with blood platelets at the heart of such events. Many studies have contributed to shed light on the importance of von Willebrand factor (VWF) interaction with its platelet receptors, glycoprotein (GP) Ib-IX-V and αIIbβ3 integrin, in promoting primary platelet adhesion and aggregation following vessel injury. This review will recapitulate our current knowledge on the subject from the rheological aspect to the spatio-temporal development of thrombus formation. We will also discuss the signaling events generated by VWF/GPIb-IX-V interaction, leading to platelet activation. Additionally, we will review the growing body of evidence gathered from the recent development of pathological mouse models suggesting that VWF binding to GPIb-IX-V is a promising target in arterial and venous pathological thrombosis. Finally, the pathological aspects of VWF and its impact on platelets will be addressed.

International treatment access and research, how you can help--interview with Dr. Peter Piot of UNAIDS. Joint United Nations Programme on HIV/AIDS. Interview by John S. James.

PubMed

Piot, P

1996-11-01

Medical advances in the United States have greatly increased the lifespan of people with AIDS, but there is no access to modern medicine for the 90 percent of AIDS patients who live in other countries. Dr. Peter Piot of the United Nations Programme on HIV/AIDS (UNAIDS) addresses the efforts of six U.N. agencies in improving treatment access throughout the world and improving research on natural and traditional medicines.

Molecular and clinical profile of von Willebrand disease in Spain (PCM-EVW-ES): comprehensive genetic analysis by next-generation sequencing of 480 patients.

PubMed

Borràs, Nina; Batlle, Javier; Pérez-Rodríguez, Almudena; López-Fernández, María Fernanda; Rodríguez-Trillo, Ángela; Lourés, Esther; Cid, Ana Rosa; Bonanad, Santiago; Cabrera, Noelia; Moret, Andrés; Parra, Rafael; Mingot-Castellano, María Eva; Balda, Ignacia; Altisent, Carme; Pérez-Montes, Rocío; Fisac, Rosa María; Iruín, Gemma; Herrero, Sonia; Soto, Inmaculada; de Rueda, Beatriz; Jiménez-Yuste, Víctor; Alonso, Nieves; Vilariño, Dolores; Arija, Olga; Campos, Rosa; Paloma, María José; Bermejo, Nuria; Berrueco, Rubén; Mateo, José; Arribalzaga, Karmele; Marco, Pascual; Palomo, Ángeles; Sarmiento, Lizheidy; Iñigo, Belén; Nieto, María Del Mar; Vidal, Rosa; Martínez, María Paz; Aguinaco, Reyes; César, Jesús María; Ferreiro, María; García-Frade, Javier; Rodríguez-Huerta, Ana María; Cuesta, Jorge; Rodríguez-González, Ramón; García-Candel, Faustino; Cornudella, Rosa; Aguilar, Carlos; Vidal, Francisco; Corrales, Irene

2017-12-01

Molecular diagnosis of patients with von Willebrand disease is pending in most populations due to the complexity and high cost of conventional molecular analyses. The need for molecular and clinical characterization of von Willebrand disease in Spain prompted the creation of a multicenter project (PCM-EVW-ES) that resulted in the largest prospective cohort study of patients with all types of von Willebrand disease. Molecular analysis of relevant regions of the VWF , including intronic and promoter regions, was achieved in the 556 individuals recruited via the development of a simple, innovative, relatively low-cost protocol based on microfluidic technology and next-generation sequencing. A total of 704 variants (237 different) were identified along VWF , 155 of which had not been previously recorded in the international mutation database. The potential pathogenic effect of these variants was assessed by in silico analysis. Furthermore, four short tandem repeats were analyzed in order to evaluate the ancestral origin of recurrent mutations. The outcome of genetic analysis allowed for the reclassification of 110 patients, identification of 37 asymptomatic carriers (important for genetic counseling) and re-inclusion of 43 patients previously excluded by phenotyping results. In total, 480 patients were definitively diagnosed. Candidate mutations were identified in all patients except 13 type 1 von Willebrand disease, yielding a high genotype-phenotype correlation. Our data reinforce the capital importance and usefulness of genetics in von Willebrand disease diagnostics. The progressive implementation of molecular study as the first-line test for routine diagnosis of this condition will lead to increasingly more personalized and effective care for this patient population. Copyright© 2017 Ferrata Storti Foundation.

Retrospektive Analyse von Zufallsbefunden, die bei Patienten mit kutanem malignen Malignom durch (18) F-Fluordeoxyglucose-PET/CT erhoben wurden.

PubMed

Conrad, Franziska; Winkens, Thomas; Kaatz, Martin; Goetze, Steven; Freesmeyer, Martin

2016-08-01

Bei der (18) F-Fluordeoxyglucose-Positronenemissionstomographie/Computertomographie (FDG-PET/CT) ergeben sich häufig Zufallsbefunde. In der vorliegenden Studie konzentrierten wir uns auf mittels FDG-PET/CT erhaltene Zufallsbefunde bei Patienten mit kutanem Melanom und überprüften deren Relevanz hinsichtlich weiterer diagnostischer Maßnahmen und Interventionen. Die Krankenakten von 181 konsekutiven Melanom-Patienten wurden retrospektiv ausgewertet, um das Management von Zufallsbefunden zu dokumentieren. Der Schwerpunkt lag dabei auf den histologischen Befunden. Bei 33 von 181 (18 %) Patienten lagen 39 relevante Zufallsbefunde vor, und zwar im Kolorektalbereich (n = 15 Patienten), in der Schilddrüse (n = 8), der Prostata (n = 2), dem Bewegungsapparat (n = 2), in Lymphknoten (n = 2), der Parotis (n = 1), den Mandeln (n = 1), den Nieren (n = 1) und der Gallenblase (n = 1). Bei 25 Patienten schlossen sich weitere diagnostische Verfahren an, wobei in 21 Fällen ein klinisches Korrelat nachgewiesen wurde. Bei 16 von 21 Patienten ergab sich eine Neoplasie, darunter fünf maligne Läsionen (vier Kolonkarzinome und ein Prostatakarzinom). Die Malignome wurden frühzeitig diagnostiziert und in der Mehrzahl der Fälle erfolgreich entfernt. Der Einsatz der FDG-PET/CT als Routine-Diagnostik wird in den Leitlinien empfohlen und ist indiziert bei malignem Melanom ab Stadium IIC. In dieser Studie wurden auf effektive Weise ansonsten nicht erkannte Krebserkrankungen, insbesondere Kolonkarzinome, detektiert. In den meisten Fällen war eine frühe Intervention möglich. Zufallsbefunde durch FDG-PET/CT sollten, unter Berücksichtigung des Zustands und der Wünsche des Patienten, mit den geeigneten diagnostischen Maßnahmen abgeklärt werden. © 2016 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.

[Kombinierte Anwendung von Strahlentherapie und adjuvanter Therapie mit einem Mistelextrakt (Viscum album L.) zur Behandlung des oralen malignen Melanoms beim Hund: Eine retrospektive Studie].

PubMed

von Bodungen, Uta; Ruess, Katja; Reif, Marcus; Biegel, Ulrike

2017-01-01

Hintergrund: Orale maligne Melanome (OMM) des Hundes zeichnen sich durch schnelles Wachstum, lokale Invasion und hohe Metastasierungsraten aus. Extrakte auf Basis von Viscum album L. (VAE) werden zunehmend in der Krebstherapie sowohl in der Human- als auch in der Veterinärmedizin eingesetzt. Ziel unserer Studie war es zu untersuchen, inwieweit die adjuvante Therapie mit VAE eine therapeutische Option zur Behandlung von OMM ist. Besonderes Augenmerk galt dabei der Überlebenszeit und möglichen Nebenwirkungen. Tiere und Methoden: 26 Hunde mit OMM, die in einem der größten veterinäronkologischen Zentren der Schweiz allesamt eine Strahlentherapie erhielten (teilweise nach operativer Tumorresektion) wurden in die retrospektive Studie eingeschlossen: 18 Hunde wurden mit VAE behandelt (1 ml VAE (Iscador®) in ansteigenden Konzentrationen von 0,1 bis 20 mg/ml subkutan 3-mal pro Woche (VAE-Gruppe), 8 erhielten keine adjuvante Behandlung (Vergleichsgruppe). Wir verglichen die Größenentwicklung der OMM sowie die Überlebenszeit. Ergebnisse: Patienten mit Bestrahlung und adjuvanter VAE-Therapie zeigten mit 236 Tagen eine signifikant längere mediane Überlebenszeit im Vergleich zu Patienten mit Bestrahlung, aber ohne adjuvante VAE-Therapie (49 Tage; Log-Rank-Test: p = 0,0047). Die VAE-Therapie verlängerte die Überlebenszeit um mehr als zwei Drittel (Hazard Ratio (HR) = 0,30, 95%-Konfidenzintervall (KI) 0,11-0,86; p = 0,024), während ein höheres Tumorstadium gemäß UICC (Union internationale contre le cancer) einen statistischen Trend zur Verdopplung des Sterberisikos zeigte (UICC-Stadium III/IV vs. I/II: HR = 2,12, 95%-KI 0,88-5,12; p = 0,095). Zwei Patienten zeigten milde Nebenwirkungen während der VAE-Behandlung. Einer der beiden zeigte 1 Tag lang ein selbstlimitiertes Fieber, bei dem anderen Patienten reduzierten wir die Dosis von einem konzentrierteren zu einem weniger konzentrierten VAE (Serie 0) aufgrund von Müdigkeit, die daraufhin verschwand

Kompressionstherapie - Versorgungspraxis: Informationsstand von Patienten mit Ulcus cruris venosum.

PubMed

Protz, Kerstin; Heyer, Kristina; Dissemond, Joachim; Temme, Barbara; Münter, Karl-Christian; Verheyen-Cronau, Ida; Klose, Katharina; Hampel-Kalthoff, Carsten; Augustin, Matthias

2016-12-01

Eine Säule der kausalen Therapie bei Patienten mit Ulcus cruris venosum ist die Kompressionstherapie. Sie unterstützt die Abheilung, reduziert Schmerzen und Rezidive und steigert die Lebensqualität. Bislang existieren kaum wissenschaftliche Daten zu dem Versorgungsstand und fachspezifischem Wissen von Patienten mit Ulcus cruris venosum. Standardisierte Fragebögen wurden bundesweit in 55 Pflegediensten, 32 Arztpraxen, vier Wundzentren und -sprechstunden sowie einem Pflegetherapiestützpunkt von Patienten mit Ulcus cruris venosum bei Erstvorstellung anonym ausgefüllt. Insgesamt nahmen 177 Patienten (Durchschnittsalter 69,4 Jahre; 75,1 % Frauen) teil. Ein florides Ulcus cruris venosum bestand im Mittel 17 Monate. 31,1 % hatten keine Kompressionstherapie, 40,1 % Binden und 28,8 % Strümpfe. Bei der Bestrumpfung hatten 13,7 % Kompressionsklasse III, 64,7 % Kompressionsklasse II und 19,6 % Kompressionsklasse I. 70,6 % legten die Strümpfe nach dem Aufstehen an, 21,1 % trugen sie Tag und Nacht. 39,2 % bereiteten die Strümpfe Beschwerden. Lediglich 11,7 % hatten eine An- und Ausziehhilfe. Die Binden wurden im Mittel 40,7 Wochen getragen und bei 69 % nicht unterpolstert. Bei 2,8 % wurde der Knöchel- und Waden-Umfang zur Erfolgskontrolle gemessen. Venensport machten 45,9 %. Ein Drittel hatte keine Kompressionsversorgung, obwohl diese eine Basismaßnahme der Therapie des Ulcus cruris venosum ist. Zudem ist deren korrekte Auswahl und Anwendung angesichts der langen Bestandsdauer der Ulzerationen zu hinterfragen. Weiterführende Fachkenntnisse bei Anwendern und Verordnern sowie Patientenschulungen sind erforderlich. © 2016 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.

Peter Mark Roget: physician, scientist, systematist; his thesaurus and his impact on 19th-century neuroscience.

PubMed

Kruger, Lawrence; Finger, Stanley

2013-01-01

Peter Mark Roget (1779-1869) is best known for his Thesaurus, a project completed late in his long life. He trained as a physician, practiced medicine, and was interested in many branches of science. Much of his life was dedicated to the systematization of knowledge and identifying relationships. Although not an experimentalist in the modern sense of the word, he contributed to "neuroscience" in journal and encyclopaedia articles, as well as in books and lectures. He wrote extensively on comparative physiology, sensory systems, phrenology, optics, and various disorders affecting the nervous system. He viewed his two-volume Bridgewater Treatise of 1834 as his most significant achievement, turning to physiology and comparative anatomy to argue that God's existence can be seen in how living forms and their components are designed. Roget was active in many scholarly organizations, most notably the Royal Society of London, where he served for more than two decades as its secretary before "retiring" to pursue his Thesaurus. © 2013 Elsevier B.V. All rights reserved.

Hypoxia and cell cycle regulation of the von Hippel-Lindau tumor suppressor

PubMed Central

Liu, Weijun; Xin, Hong; Eckert, David T.; Brown, Julie A.; Gnarra, James R.

2010-01-01

Inactivation of von Hippel-Lindau tumor suppressor protein (pVHL) is associated with von Hippel-Lindau disease, an inherited cancer syndrome, as well as the majority of patients with sporadic clear cell renal carcinoma (RCC). While the involvement of pVHL in oxygen sensing through targeting HIFα subunits to ubiquitin-dependent proteolysis has been well documented, less is known about pVHL regulation under both normoxic and hypoxic conditions. We found that pVHL levels decreased in hypoxia and that hypoxia-induced cell cycle arrest is associated with pVHL expression in RCC cells. pVHL levels fluctuate during the cell cycle, paralleling cyclin B1 levels, with decreased levels in mitosis and G1. pVHL contains consensus Destruction box sequences, and pVHL associates with Cdh1, an activator of the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin ligase. We show that pVHL has a decreased half-life in G1, Cdh1 downregulation results in increased pVHL expression, while Cdh1 overexpression results in decreased pVHL expression. Taken together these results suggest that pVHL is a novel substrate of APC/CCdh1. Destruction box-independent pVHL degradation was also detected, indicating that other ubiquitin ligases are also activated for pVHL degradation. PMID:20802534

[Homocysteine and von Willebrand factor in chronic alcoholism].

PubMed

Koriakin, A M; Epifantseva, N N; Dadyka, I V; Gorbatovskiĭ, Ia A

2010-04-01

The levels of homocysteine (HC) and von Willebrand factor (VWF) as cardiovascular risk factors were studied in patients with Stage II chronic alcoholism. Forty-one men with Stage II chronic alcoholism without clinical signs of somatic and infectious diseases were examined. Their median age was 37 (range 32-40) years; the alcoholization period was 12 (range 8-17) years. Plasma HC and VWF (amount and activity) levels were determined. In 63.4% of chronic alcoholic patients, HC levels was twice as high as in the controls; in 80.6%, both the content and activity of VWF were increased. There was no correlation between the levels of HC and VWF. Vascular endothelial damage concurrent with hyperhomocysteinemia increases a cardiovascular risk in patients with Stage II chronic alcoholism.

Neurocognitive profile of a young adolescent with DK phocomelia/von Voss phocomelia/von Voss Cherstvoy syndrome.

PubMed

Antonini, Tanya N; Van Horn Kerne, Valerie; Axelrad, Marni E; Karaviti, Lefkothea P; Schwartz, David D

2015-07-01

DK phocomelia/von Voss Cherstvoy syndrome is a rare condition characterized by upper limb and urogenital abnormalities and various brain anomalies. Previously reported cases have noted significant developmental delays, although no formal testing of cognitive abilities has been reported. In this paper we describe results from a comprehensive neuropsychological evaluation of a 12-year-old male with DK phocomelia syndrome. Test findings indicated mild impairment in intellectual functioning, with more significant impairment in adaptive skills and academic achievement. The neuropsychological profile converged with neurological findings, showing a distinct pattern of strengths and weaknesses that suggests functional compromise of posterior brain regions with relatively well-preserved functioning of more anterior regions. Specifically, impairments were evident in perceptual reasoning, visual perception, and visuomotor integration, whereas normal or near normal functioning was evident in memory, receptive language, social cognition, attention, and most aspects of executive functioning. To our knowledge this is the first report to describe the neurocognitive profile of an individual with DK phocomelia syndrome. © 2015 Wiley Periodicals, Inc.

[Countryside obstetrics--Dr. Franz von Ottenthal and the South Tyrolean Medical Market (1860-1869)].

PubMed

Hilber, Marina

2012-01-01

The paper focuses on the structure of the obstetric market in a rural region of alpine South Tyrol (today: Italy) throughout the 1860s. Besides midwives and parturient women, also male obstetricians are traceable in the actual research area of the Tauferer Ahrntal. Among them was the general practitioner Dr. Franz von Ottenthal, whose medical records (Historiae Morborum, 1847-1899) are used to reconstruct the participation of physicians in the obstetric market. Special emphasis lies on the evaluation of the predominant hierarchies (midwives/surgeons/physicians) and the position of Franz von Ottenthal in this specialized medical sub-segment. Therefore, the quantitative extent of obstetric intervention as well as the qualitative dimension of treatments (medication, surgeries) is investigated. So far, the relevance of Ottenthals obstetric practice as to the gender ratio has been measured as rather high, considering that he generally treated more female than male patients. An attempt will be made to estimate the significance of the obstetric segment within his practice in order to find an explanatory approach for the higher female medical demand.

PREFACE: EmerQuM 11: Emergent Quantum Mechanics 2011 (Heinz von Foerster Congress)

NASA Astrophysics Data System (ADS)

Grössing, Gerhard

2012-05-01

These proceedings comprise the plenary lectures and poster contributions of the 'Heinz von Foerster Conference 2011' on Emergent Quantum Mechanics (EmerQuM11), which was held at the University of Vienna, 11-13 November 2011. With the 5th International Heinz von Foerster Conference convened at the occasion of von Foerster's 100th birthday, the organizers opted for a twin conference to take place at the Large and Small Ceremonial Halls of the University's main building, respectively. The overall topic was chosen as 'Self-Organization and Emergence', a topic to which von Foerster was an early contributor. While the first conference ('Self-Organization and Emergence in Nature and Society') addressed a more general audience, the second one ('Emergent Quantum Mechanics') was intended as a specialist meeting with a contemporary topic that could both serve as an illustration of von Foerster's intellectual heritage and, more generally, point towards future directions in physics. We thus intended to bring together many of those physicists who are interested in or are working on attempts to understand quantum mechanics as emerging from a suitable classical (or, more generally, deeper level) physics. EmerQuM11 was organized by the Austrian Institute for Nonlinear Studies (AINS), with essential support from the Wiener Institute for Social Science Documentation and Methodology (WISDOM), the Department of Contemporary History at the University of Vienna, and the Heinz von Foerster-Gesellschaft. There were a number of individuals who contributed to the smooth course of our meeting and whom I would like to sincerely thank: Christian Bischof, Thomas Elze, Marianne Ertl, Gertrud Hafner, Werner Korn, Angelika Krawanja, Florian Krug and his team, Sonja Lang, Albert Müller, Ilse Müller, Irene Müller, Karl Müller, Armin Reautschnig, Marion Schirrmacher, Anton Staudinger, Roman Zlabinger, and, last but not least, my AINS colleagues Siegfried Fussy, Herbert Schwabl and Johannes Mesa

Wilhelm von Humboldt and the "Orient": On Edward W. Said's Remarks on Humboldt's Orientalist Studies

ERIC Educational Resources Information Center

Messling, Markus

2008-01-01

From an epistemological perspective, Wilhelm von Humboldt's studies on the Oriental and East Asian languages and writing systems (Egyptian hieroglyphs, Sanskrit, Chinese, Polynesian) raise the question of his position in the Orientalist discourse of his time. Said [Said, E.W., 1978. "Orientalism. Western Conceptions of the Orient, fourth…

Identification and characterization of the elusive mutation causing the historical von Willebrand Disease type IIC Miami.

PubMed

Obser, T; Ledford-Kraemer, M; Oyen, F; Brehm, M A; Denis, C V; Marschalek, R; Montgomery, R R; Sadler, J E; Schneppenheim, S; Budde, U; Schneppenheim, R

2016-09-01

Essentials Von Willebrand disease IIC Miami features high von Willebrand factor (VWF) with reduced function. We aimed to identify and characterize the elusive underlying mutation in the original family. An inframe duplication of VWF exons 9-10 was identified and characterized. The mutation causes a defect in VWF multimerization and decreased VWF clearance from the circulation. Background A variant of von Willebrand disease (VWD) type 2A, phenotype IIC (VWD2AIIC), is characterized by recessive inheritance, low von Willebrand factor antigen (VWF:Ag), lack of VWF high-molecular-weight multimers, absence of VWF proteolytic fragments and mutations in the VWF propeptide. A family with dominantly inherited VWD2AIIC but markedly elevated VWF:Ag of > 2 U L(-1) was described as VWD type IIC Miami (VWD2AIIC-Miami) in 1993; however, the molecular defect remained elusive. Objectives To identify the molecular mechanism underlying the phenotype of the original VWD2AIIC-Miami. Patients and Methods We studied the original family with VWD2AIIC-Miami phenotypically and by genotyping. The identified mutation was recombinantly expressed and characterized by standard techniques, confocal imaging and in a mouse model, respectively. Results By Multiplex ligation-dependent probe amplification we identified an in-frame duplication of VWF exons 9-10 (c.998_1156dup; p.Glu333_385dup) in all patients. Recombinant mutant (rm)VWF only presented as a dimer. Co-expressed with wild-type VWF, the multimer pattern was indistinguishable from patients' plasma VWF. Immunofluorescence studies indicated retention of rmVWF in unusually large intracellular granules in the endoplasmic reticulum. ADAMTS-13 proteolysis of rmVWF under denaturing conditions was normal; however, an aberrant proteolytic fragment was apparent. A decreased ratio of VWF propeptide to VWF:Ag and a 1-desamino-8-d-arginine vasopressin (DDAVP) test in one patient indicated delayed VWF clearance, which was supported by clearance data after

Constraints on hydrocarbon and organic acid abundances in hydrothermal fluids at the Von Damm vent field, Mid-Cayman Rise (Invited)

NASA Astrophysics Data System (ADS)

McDermott, J. M.; Seewald, J.; German, C. R.; Sylva, S. P.

2013-12-01

The generation of organic compounds in vent fluids has been of interest since the discovery of seafloor hydrothermal systems, due to implications for the sustenance of present-day microbial populations and their potential role in the origin of life on early Earth. Possible sources of organic compounds in hydrothermal systems include microbial production, thermogenic degradation of organic material, and abiotic synthesis. Abiotic organic synthesis reactions may occur during active circulation of seawater-derived fluids through the oceanic crust or within olivine-hosted fluid inclusions containing carbon-rich magmatic volatiles. H2-rich end-member fluids at the Von Damm vent field on the Mid-Cayman Rise, where fluid temperatures reach 226°C, provide an exciting opportunity to examine the extent of abiotic carbon transformations in a highly reducing system. Our results indicate multiple sources of carbon compounds in vent fluids at Von Damm. An ultramafic-influenced hydrothermal system located on the Mount Dent oceanic core complex at 2350 m depth, Von Damm vent fluids contain H2, CH4, and C2+ hydrocarbons in high abundance relative to basalt-hosted vent fields, and in similar abundance to other ultramafic-hosted systems, such as Rainbow and Lost City. The CO2 content and isotopic composition in end-member fluids are virtually identical to bottom seawater, suggesting that seawater DIC is unchanged during hydrothermal circulation of seawater-derived fluids. Accordingly, end-member CH4 that is present in slightly greater abundance than CO2 cannot be generated from reduction of aqueous CO2 during hydrothermal circulation. We postulate that CH4 and C2+ hydrocarbons that are abundantly present in Von Damm vent fluids reflect leaching of fluids from carbon- and H2-rich fluid inclusions hosted in plutonic rocks. Geochemical modeling of carbon speciation in the Von Damm fluids suggests that the relative abundances of CH4, C2+ hydrocarbons, and CO2 are consistent with

Plasma and urinary endothelin-1 titers and plasma von Willebrand activity in Pseudoxanthoma elasticum.

PubMed

Amadeo, A; Bertulezzi, G; Civelli, L; Porta, C; Moroni, M

1998-10-01

We found high endothelin-1 and von Willebrand factor plasma titers not only in two individuals (daughter and father) affected with Pseudoxanthoma elasticum but also in a young unaffected relative. These findings raise the possibility that these molecules could be the first biochemical fingerprints of this, still not clinically evident, rare inherited disorder of elastic tissue.

'Rediscovery' revised - the cooperation of Erich and Armin von Tschermak-Seysenegg in the context of the 'rediscovery' of Mendel's laws in 1899-1901.

PubMed

Simunek, M; Hossfeld, U; Wissemann, V

2011-11-01

The 'rediscovery' of Mendel's laws in 1900 is seen as a turning point in modern research on heredity and genetics. In the first half of the 20th century it was generally held that the 'rediscovery' was made several times, independently, and in a parallel fashion by three European botanists (Carl Correns, Hugo de Vries and Erich von Tschermak-Seysenegg). Since the 1950s, however, serious questions have arisen concerning both the chronology and the specific conceptual contribution of the scientists involved. Not only the independence but also parallelism was analysed in the context of individual research programmes of all three of these scholars. The youngest of them, Austrian botanist Erich von Tschermak-Seysenegg, was excluded from the rank of 'rediscoverers'. It is the aim of this paper to use new archival evidence and add important facts both to the chronology and conceptual framework of Erich von Tschermak-Seysenegg's work. An entirely new aspect is added by identifying his older brother, the physiologist Armin von Tschermak-Seysenegg (1870-1952), as a significant spiritus movens of the events of 1900 and 1901. A selected part of their correspondence, covering the period from 13 March 1898 until 19 November 1901, is made available in transcriptions. © 2011 German Botanical Society and The Royal Botanical Society of the Netherlands.

Hydraulic seals and their origin: Evidence from the stable isotope geochemistry of dolomites in the Middle Ordovician St. Peter Sandstone, Michigan basin

DOE Office of Scientific and Technical Information (OSTI.GOV)

Winter, B.L.; Johnson, C.M.; Valley, J.W.

1995-01-01

Regionally extensive, overpressured natural gas pools within the St. Peter Sandstone (Middle Ordovician) of the Michigan basin are bounded by rock types that include 3-7-m-thick zones of low-permeability, low-porosity carbonates or diagenetically banded quartz sandstones. Replacive dolomite from an approximately 5-m-thick carbonate interval in the east-central portion of the Michigan basin has very low {delta}{sup 13}C values that systematically decrease from approximately -5% at the top to -10% (PDB) at the base. {delta}{sup 18}O values for the replacive dolomite also decrease systematically with depth from approximately 27 to 23% (SMOW). These data suggest an upward decrease in isotope exchange betweenmore » the replacive dolomitization fluid and the precursors rock (i.e., the system was rock dominated at the top of the carbonate interval), which implies upward, cross-formational movement of the dolomitizing fluid. Fluid-rock interaction modeling suggest that the dolomitizing fluid had a total dissolved carbon (TDC) content of approximately 4000 ppm and a {delta}{sup 13}C value of -27%, which indicates that the carbon was primarily derived from organic diagenesis. Sr isotope and major element data suggest that this dolomitizing fluid had a modified seawater origin. The {delta}{sup 13}C values of sandstone intervals from three locations in the central portion of the Michigan basin range from -9 to -4% and are relatively invariant at a particular locality; therefore, the TDC of the dolomitizing fluid in the central Michigan basin is interpreted to have contained only about 20-30% organic carbon. The fact that all dolomites analyzed in the St. Peter Sandstone have much lower {Delta}{sup 13}C values that carbonates in adjacent formations indicates that dolomitization and the formation of hydraulic seals were related to organic matter diagenesis.« less

Modeling of a Von Platen-Munters diffusion absorption refrigeration cycle

NASA Astrophysics Data System (ADS)

Agostini, Bruno; Agostini, Francesco; Habert, Mathieu

2016-09-01

This article presents a thermodynamical model of a Von-Platen diffusion absorption refrigeration cycle for power electronics applications. It is first validated by comparison with data available in the literature for the classical water-ammonia-helium cycle for commercial absorption fridges. Then new operating conditions corresponding to specific ABB applications, namely high ambient temperature and new organic fluids combinations compatible with aluminium are simulated and discussed. The target application is to cool power electronics converters in harsh environments with high ambient temperature by providing refrigeration without compressor, for passive components losses of about 500 W, with a compact and low cost solution.

Contiguity and Entire Separability of States on von Neumann Algebras

NASA Astrophysics Data System (ADS)

Haliullin, Samigulla

2017-12-01

We introduce the notions of the contiguity and entirely separability for two sequences of states on von Neumann algebras. The ultraproducts technique allows us to reduce the study of the contiguity to investigation of the equivalence for two states. Here we apply the Ocneanu ultraproduct and the Groh-Raynaud ultraproduct (see Ocneanu (1985), Groh (J. Operator Theory, 11, 2, 395-404 1984), Raynaud (J. Operator Theory, 48, 1, 41-68, 2002), Ando and Haagerup (J. Funct. Anal., 266, 12, 6842-6913, 2014)), as well as the technique developed in Mushtari and Haliullin (Lobachevskii J. Math., 35, 2, 138-146, 2014).

Linking contemporary high resolution magnetic resonance imaging to the von Economo legacy: A study on the comparison of MRI cortical thickness and histological measurements of cortical structure.

PubMed

Scholtens, Lianne H; de Reus, Marcel A; van den Heuvel, Martijn P

2015-08-01

The cerebral cortex is a distinctive part of the mammalian nervous system, displaying a spatial variety in cyto-, chemico-, and myelinoarchitecture. As part of a rich history of histological findings, pioneering anatomists von Economo and Koskinas provided detailed mappings on the cellular structure of the human cortex, reporting on quantitative aspects of cytoarchitecture of cortical areas. Current day investigations into the structure of human cortex have embraced technological advances in Magnetic Resonance Imaging (MRI) to assess macroscale thickness and organization of the cortical mantle in vivo. However, direct comparisons between current day MRI estimates and the quantitative measurements of early anatomists have been limited. Here, we report on a simple, but nevertheless important cross-analysis between the histological reports of von Economo and Koskinas on variation in thickness of the cortical mantle and MRI derived measurements of cortical thickness. We translated the von Economo cortical atlas to a subdivision of the commonly used Desikan-Killiany atlas (as part of the FreeSurfer Software package and a commonly used parcellation atlas in studies examining MRI cortical thickness). Next, values of "width of the cortical mantle" as provided by the measurements of von Economo and Koskinas were correlated to cortical thickness measurements derived from high-resolution anatomical MRI T1 data of 200+ subjects of the Human Connectome Project (HCP). Cross-correlation revealed a significant association between group-averaged MRI measurements of cortical thickness and histological recordings (r = 0.54, P < 0.001). Further validating such a correlation, we manually segmented the von Economo parcellation atlas on the standardized Colin27 brain dataset and applied the obtained three-dimensional von Economo segmentation atlas to the T1 data of each of the HCP subjects. Highly consistent with our findings for the mapping to the Desikan-Killiany regions, cross

Context-invariant quasi hidden variable (qHV) modelling of all joint von Neumann measurements for an arbitrary Hilbert space

DOE Office of Scientific and Technical Information (OSTI.GOV)

Loubenets, Elena R.

We prove the existence for each Hilbert space of the two new quasi hidden variable (qHV) models, statistically noncontextual and context-invariant, reproducing all the von Neumann joint probabilities via non-negative values of real-valued measures and all the quantum product expectations—via the qHV (classical-like) average of the product of the corresponding random variables. In a context-invariant model, a quantum observable X can be represented by a variety of random variables satisfying the functional condition required in quantum foundations but each of these random variables equivalently models X under all joint von Neumann measurements, regardless of their contexts. The proved existence ofmore » this model negates the general opinion that, in terms of random variables, the Hilbert space description of all the joint von Neumann measurements for dimH≥3 can be reproduced only contextually. The existence of a statistically noncontextual qHV model, in particular, implies that every N-partite quantum state admits a local quasi hidden variable model introduced in Loubenets [J. Math. Phys. 53, 022201 (2012)]. The new results of the present paper point also to the generality of the quasi-classical probability model proposed in Loubenets [J. Phys. A: Math. Theor. 45, 185306 (2012)].« less

John von Neumann and Klaus Fuchs: an Unlikely Collaboration

NASA Astrophysics Data System (ADS)

Bernstein, Jeremy

2010-03-01

I discuss the origin of the idea of making a fusion (hydrogen) bomb and the physics involved in it, and then turn to the design proposed for one by the unlikely collaborators John von Neumann and Klaus Fuchs in a patent application they filed at Los Alamos in May 1946, which Fuchs passed on to the Russians in March 1948, and which with substantial modifications was tested on the island of Eberiru on the Eniwetok atoll in the South Pacific on May 8, 1951. This test showed that the fusion of deuterium and tritium nuclei could be ignited, but that the ignition would not propagate because the heat produced was rapidly radiated away. Meanwhile, Stanislaw Ulam and C.J. Everett had shown that Edward Teller’s Classical Super could not work, and at the end of December 1950, Ulam had conceived the idea of super compression, using the energy of a fission bomb to compress the fusion fuel to such a high density that it would be opaque to the radiation produced. Once Teller understood this, he invented a greatly improved, new method of compression using radiation, which then became the heart of the Ulam-Teller bomb design, which was tested, also in the South Pacific, on November 1, 1952. The Russians have freely acknowledged that Fuchs gave them the fission bomb, but they have insisted that no one gave them the fusion bomb, which grew out of design involving a fission bomb surrounded by alternating layers of fusion and fission fuels, and which they tested on November 22, 1955. Part of the irony of this story is that neither the American nor the Russian hydrogen-bomb programs made any use of the brilliant design that von Neumann and Fuchs had conceived as early as 1946, which could have changed the entire course of development of both programs.

Einsatz und Wirksamkeit von Systemtherapien bei Erwachsenen mit schwerer Neurodermitis: Erste Ergebnisse des deutschen Neurodermitis-Registers TREATgermany.

PubMed

Schmitt, Jochen; Abraham, Susanne; Trautmann, Freya; Stephan, Victoria; Fölster-Holst, Regina; Homey, Bernhard; Bieber, Thomas; Novak, Natalija; Sticherling, Michael; Augustin, Matthias; Kleinheinz, Andreas; Elsner, Peter; Weidinger, Stephan; Werfel, Thomas

2017-01-01

Versorgungsregister dienen der Erfassung des Einsatzes und der Wirksamkeit von Therapien unter realen Versorgungsbedingungen und sind als Basis einer evidenzbasierten Gesundheitsversorgung unverzichtbar. Das deutsche Neurodermitis-Register TREATgermany wurde als weltweit erstes Register für Patienten mit schwerer Neurodermitis 2011 initiiert. Erwachsene mit schwerer Neurodermitis (aktuelle/frühere antientzündliche Systemtherapie und/oder objektiver SCORAD ≥ 40) werden über einen Zeitraum von 24 Monaten prospektiv beobachtet. Anhand validierter Erhebungsinstrumente werden die klinische Erkrankungsschwere (EASI, SCORAD), Lebensqualität (DLQI), Symptome, globale Erkrankungsschwere sowie die Patientenzufriedenheit erfasst und die durchgeführten Therapien dokumentiert. Die vorliegende Analyse beschreibt die Charakteristika, Therapiewahl und Wirksamkeit der eingesetzten antiinflammatorischen Systemtherapien der bis Oktober 2014 eingeschlossenen Patienten. An fünf Zentren wurden insgesamt 78 Patienten (Durchschnittsalter 39 Jahre, 61 % männlich) eingeschlossen. Bei den Patienten besteht eine hohe Inanspruchnahme ambulanter und stationärer Leistungen. Ciclosporin war das am häufigsten eingesetzte Systemtherapeutikum und zeigte die höchste klinische Effektivität (EASI-50-Ansprechrate 51 %; EASI-75-Ansprechrate 34 % nach zwölfwöchiger Therapie). Azathioprin, Methotrexat (MTX), Prednisolon oral, Mycophenolat, Alitretinoin und Leflunomid wurden ebenfalls bei einzelnen Patienten eingesetzt. Die vorliegende Registerauswertung gibt wichtige Hinweise zur derzeitigen Versorgung von Erwachsenen mit schwerer Neurodermitis in Deutschland, dokumentiert die hohe Erkrankungslast, den Nutzen vorhandener Therapien und den Bedarf an weiteren, effektiven und in der Langzeitanwendung sicheren Therapieoptionen. © 2017 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.

Parameter estimation of the Farquhar-von Caemmerer-Berry biochemical model from photosynthetic carbon dioxide response curves

USDA-ARS?s Scientific Manuscript database

The methods of Sharkey and Gu for estimating the eight parameters of the Farquhar-von Caemmerer-Berry (FvBC) model were examined using generated photosynthesis versus intercellular carbon dioxide concentration (A/Ci) datasets. The generated datasets included data with (A) high accuracy, (B) normal ...

Variabilität des Reviergesangs des Buchfinken (Fringilla coelebs) zur Raum-Zeit-Beschreibung von Metapopulationen

NASA Astrophysics Data System (ADS)

Nolte, Björn

2003-10-01

Der Buchfinkengesang wurde in Potsdam in zwei Hauptpopulationen über drei Jahre aufgenommen. Jedes Individuum wurde eindeutig am individuellen Strophentypenrepertoire identifiziert. Ein weiterer Punkt der die individuelle Wiedererkennung bestätigt ist die hohe Standorttreue der adulten Männchen. Die beschriebene Methode eignet sich für die Untersuchung von gesamten Populationen, um den Wandel des Gesangs von Populationen in Raum und Zeit zu beschreiben. Die Haupterkenntnisse der Arbeit sind: - Die Gesamtanzahl der Grundstrophentypen innerhalb einer Population bleibt über Jahre konstant. - Die relative Häufigkeit jedes einzelnen Strophentyps variiert von Jahr zu Jahr und von Population zu Population. - Gesangslernen erfolgt exakt mit einem Korrektheitsgrad von mindestens 96%. - Das Song-Sharing ist innerhalb der Population hoch. Die diskutierten Mechanismen für das Song-Sharing sind: Die Lebenserwartung, das Zugverhalten, das Lernverhalten, die Etabliertheit von Strophentypen, Weibchenpräferenzen und die Reaktionen der territorialen Männchen. - Weiterhin wurde ein Modell zur kulturellen Evolution des Buchfinkengesangs programmiert, um die Rolle der Einflussfaktoren, wie Fehlerquote, Abwanderungsrate und Laufzeit zu ermitteln. Der Wandel des Dialektes erfolgt graduell in Raum und Zeit. Daher sind keine scharfen Dialektgrenzen anzutreffen. Trotz dieser Tatsache markieren die etablierten Strophentypen die Population. 50 % der Juvenilen siedeln am Geburtsort, auf diese Weise bleibt der Dialekt erhalten und Inzest wird vermieden. -Analysiert man das Repertoire benachbarten Männchen bei isolierten Alleen, so entspricht die Gesangsangleichung in etwa dem Zufall. -Intraindividuelle Vergleiche der quantitativen Parameter des jeweiligen Strophentyps wurden saisonal und annuell durchgeführt. Saisonal konnten für einen Strophentyp ein Trend ermittelt werden. Bei jährlichen Vergleichen konnten intraindividuell ausschließlich nicht signifikante Ergebnisse ermittelt

Cold-Air-Pool Structure and Evolution in a Mountain Basin: Peter Sinks, Utah

DOE Office of Scientific and Technical Information (OSTI.GOV)

Clements, Craig B.; Whiteman, Charles D.; Horel, John D.

2003-06-01

The evolution of potential temperature and wind structure during the buildup of nocturnal cold-air pools was investigated during clear, dry, September nights in Utah's Peter Sinks basin, a 1-km-diameter limestone sinkhole that holds the Utah minimum temperature record of -56 C. The evolution of cold-pool characteristics depended on the strength of prevailing flows above the basin. On an undisturbed day, a 30 C diurnal temperature range and a strong nocturnal potential temperature inversion (22 K in 100 m) were observed in the basin. Initially, downslope flows formed on the basin sidewalls. As a very strong potential temperature jump (17 K)more » developed at the top of the cold pool, however, the winds died within the basin and over the sidewalls. A persistent turbulent sublayer formed below the jump. Turbulent sensible heat flux on the basin floor became negligible shortly after sunset while the basin atmosphere continued to cool. Temperatures over the slopes, except for a 1 to 2-m-deep layer, became warmer than over the basin center at the same altitude. Cooling rates for the entire basin near sunset were comparable to the 90 W m-2 rate of loss of net longwave radiation at the basin floor, but these rates decreased to only a few watts per square meter by sunrise. This paper compares the observed cold-pool buildup in basins with inversion buildup in valleys.« less

Stochastic von Bertalanffy models, with applications to fish recruitment.

PubMed

Lv, Qiming; Pitchford, Jonathan W

2007-02-21

We consider three individual-based models describing growth in stochastic environments. Stochastic differential equations (SDEs) with identical von Bertalanffy deterministic parts are formulated, with a stochastic term which decreases, remains constant, or increases with organism size, respectively. Probability density functions for hitting times are evaluated in the context of fish growth and mortality. Solving the hitting time problem analytically or numerically shows that stochasticity can have a large positive impact on fish recruitment probability. It is also demonstrated that the observed mean growth rate of surviving individuals always exceeds the mean population growth rate, which itself exceeds the growth rate of the equivalent deterministic model. The consequences of these results in more general biological situations are discussed.