Science.gov

Sample records for pittsburgh pa usa

  1. 76 FR 47993 - Safety Zone; Allegheny River; Pittsburgh, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-08

    ... that will occur in the city of Pittsburgh, PA on August 6, 2011 (rain date August 7, 2011). Under 5 U.S... occur in the city of Pittsburgh, PA on August 6, 2011 (rain date August 7, 2011). Basis and Purpose The.... on August 6, 2011, with a rain date of August 7, 2011 from 9:30 p.m. to 11 p.m. The Captain of...

  2. 75 FR 81469 - Safety Zone; Allegheny River, Pittsburgh, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-28

    ...-2010-1082 and are available online by going to http://www.regulations.gov , inserting USCG-2010-1082 in.... 2064; Department of Homeland Security Delegation No. 0170.1. 0 2. Add Sec. 165.T08-1082 to read as follows: Sec. 165.T08-1082 Safety Zone; Allegheny River, Pittsburgh, PA. (a) Location. The following...

  3. [Proceedings of the] International Conference on Educational Data Mining (EDM) (3rd, Pittsburgh, PA, July 11-13, 2010)

    ERIC Educational Resources Information Center

    Baker, Ryan S. J. d., Ed.; Merceron, Agathe, Ed.; Pavlik, Philip I., Jr., Ed.

    2010-01-01

    The Third International Conference on Data Mining (EDM 2010) was held in Pittsburgh, PA, USA. It follows the second conference at the University of Cordoba, Spain, on July 1-3, 2009 and the first edition of the conference held in Montreal in 2008, and a series of workshops within the AAAI, AIED, EC-TEL, ICALT, ITS, and UM conferences. EDM 2011…

  4. 75 FR 56866 - Special Local Regulation; Monongahela River, Pittsburgh, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-17

    ... special local regulation is needed to safeguard participants of the Pittsburgh Dragon Boat Festival from... because immediate action is needed to safeguard participants during the Pittsburgh Dragon Boat Festival... immediate action is needed to safeguard participants during the Pittsburgh Dragon Boat Festival from...

  5. 75 FR 38146 - Pittsburgh Coatings, Inc., Ambridge, PA; Notice of Revised Determination on Reconsideration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-01

    ... Register on May 20, 2010 (75 FR 28301). The workers were engaged in employment related to the production of... Employment and Training Administration Pittsburgh Coatings, Inc., Ambridge, PA; Notice of Revised... facts obtained on reconsideration, I determine that workers of Pittsburgh Coatings, Inc.,...

  6. Lifestyle characteristics assessment of Japanese in Pittsburgh, USA.

    PubMed

    Hirooka, Nobutaka; Takedai, Teiichi; D'Amico, Frank

    2012-04-01

    Lifestyle-related chronic diseases such as cancer and cardiovascular disease are the greatest public health concerns. Evidence shows Japanese immigrants to a westernized environment have higher incidence of lifestyle-related diseases. However, little is known about lifestyle characteristics related to chronic diseases for Japanese in a westernized environment. This study is examining the gap in lifestyle by comparing the lifestyle prevalence for Japanese in the US with the Japanese National Data (the National Health and Nutrition Survey in Japan, J-NHANS) as well as the Japan National Health Promotion in the twenty-first Century (HJ21) goals. Japanese adults were surveyed in Pittsburgh, USA, regarding their lifestyle (e.g., diet, exercise, smoking, stress, alcohol, and oral hygiene). The prevalence was compared with J-NHANS and HJ21 goals. Ninety-three responded (response rate; 97.9%). Japanese men (n = 38) and women (n = 55) in Pittsburgh smoke less than Japanese in Japan (P < 0.001 for both genders). Japanese in Pittsburgh perform less physical activity in daily life and have lower prevalence of walking more than 1 h per day (P < 0.001 for both genders). Japanese women in Pittsburgh have significantly higher prevalence of stress than in Japan (P = 0.004). Japanese men in Pittsburgh do not reach HJ21 goal in weight management, BMI, use of medicine or alcohol to sleep, and sleep quality. Japanese women in Pittsburgh do not reach HJ21 goal in weight management and sleep quality. In conclusion, healthy lifestyle promotion including exercise and physical activity intervention for Japanese living in a westernized environment is warranted. PMID:21874580

  7. 78 FR 22285 - Notice of Inventory Completion: Carnegie Museum of Natural History, Pittsburgh, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-15

    ... National Park Service Notice of Inventory Completion: Carnegie Museum of Natural History, Pittsburgh, PA AGENCY: National Park Service, Interior. ACTION: Notice. SUMMARY: The Carnegie Museum of Natural History... associated funerary objects should submit a written request to the Carnegie Museum of Natural History. If...

  8. 77 FR 69591 - Expansion and Reorganization of Foreign-Trade Zone 33 Pittsburgh, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-20

    ... Register (76 FR 72673-72674, 11/25/11) and the application has been processed pursuant to the FTZ Act and... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE Foreign-Trade Zones Board Expansion and Reorganization of Foreign-Trade Zone 33 Pittsburgh, PA Pursuant...

  9. 75 FR 13488 - Expansion of Foreign-Trade Zone 33: Pittsburgh, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-22

    ...); Whereas, notice inviting public comment was given in the Federal Register (74 FR 17453, 4/15/09), and the... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE Foreign-Trade Zones Board Expansion of Foreign-Trade Zone 33: Pittsburgh, PA Pursuant to its...

  10. Vulnerability studies and integrated assessments for hazard risk reduction in Pittsburgh, PA (Invited)

    NASA Astrophysics Data System (ADS)

    Klima, K.

    2013-12-01

    Today's environmental problems stretch beyond the bounds of most academic disciplines, and thus solutions require an interdisciplinary approach. For instance, the scientific consensus is changes in the frequency and severity of many types of extreme weather events are increasing (IPCC 2012). Yet despite our efforts to reduce greenhouse gases, we continue to experience severe weather events such as Superstorm Sandy, record heat and blizzards, and droughts. These natural hazards, combined with increased vulnerability and exposure, result in longer-lasting disruptions to critical infrastructure and business continuity throughout the world. In order to protect both our lives and the economy, we must think beyond the bounds of any one discipline to include an integrated assessment of relevant work. In the wake of recent events, New York City, Washington, DC, Chicago, and a myriad of other cities have turned to their academic powerhouses for assistance in better understanding their vulnerabilities. This talk will share a case study of the state of integrated assessments and vulnerability studies of energy, transportation, water, real estate, and other main sectors in Pittsburgh, PA. Then the talk will use integrated assessment models and other vulnerability studies to create coordinated sets of climate projections for use by the many public agencies and private-sector organizations in the region.

  11. 5. Photocopy of Photograph (from Art Work of Pittsburgh. Pittsburgh: ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Photocopy of Photograph (from Art Work of Pittsburgh. Pittsburgh: W.H. Parish Publishing Co., 1893) SOUTH FRONT (AT LEFT) - Penn & Liberty Avenues (Commercial Buildings), Arbuthnot Building, 719-721 Liberty Avenue, Pittsburgh, Allegheny County, PA

  12. Social Contact Networks and Mixing among Students in K-12 Schools in Pittsburgh, PA

    PubMed Central

    Guclu, Hasan; Read, Jonathan; Vukotich, Charles J.; Galloway, David D.; Gao, Hongjiang; Rainey, Jeanette J.; Uzicanin, Amra; Zimmer, Shanta M.; Cummings, Derek A. T.

    2016-01-01

    Students attending schools play an important role in the transmission of influenza. In this study, we present a social network analysis of contacts among 1,828 students in eight different schools in urban and suburban areas in and near Pittsburgh, Pennsylvania, United States of America, including elementary, elementary-middle, middle, and high schools. We collected social contact information of students who wore wireless sensor devices that regularly recorded other devices if they are within a distance of 3 meters. We analyzed these networks to identify patterns of proximal student interactions in different classes and grades, to describe community structure within the schools, and to assess the impact of the physical environment of schools on proximal contacts. In the elementary and middle schools, we observed a high number of intra-grade and intra-classroom contacts and a relatively low number of inter-grade contacts. However, in high schools, contact networks were well connected and mixed across grades. High modularity of lower grades suggests that assumptions of homogeneous mixing in epidemic models may be inappropriate; whereas lower modularity in high schools suggests that homogenous mixing assumptions may be more acceptable in these settings. The results suggest that interventions targeting subsets of classrooms may work better in elementary schools than high schools. Our work presents quantitative measures of age-specific, school-based contacts that can be used as the basis for constructing models of the transmission of infections in schools. PMID:26978780

  13. Social Contact Networks and Mixing among Students in K-12 Schools in Pittsburgh, PA.

    PubMed

    Guclu, Hasan; Read, Jonathan; Vukotich, Charles J; Galloway, David D; Gao, Hongjiang; Rainey, Jeanette J; Uzicanin, Amra; Zimmer, Shanta M; Cummings, Derek A T

    2016-01-01

    Students attending schools play an important role in the transmission of influenza. In this study, we present a social network analysis of contacts among 1,828 students in eight different schools in urban and suburban areas in and near Pittsburgh, Pennsylvania, United States of America, including elementary, elementary-middle, middle, and high schools. We collected social contact information of students who wore wireless sensor devices that regularly recorded other devices if they are within a distance of 3 meters. We analyzed these networks to identify patterns of proximal student interactions in different classes and grades, to describe community structure within the schools, and to assess the impact of the physical environment of schools on proximal contacts. In the elementary and middle schools, we observed a high number of intra-grade and intra-classroom contacts and a relatively low number of inter-grade contacts. However, in high schools, contact networks were well connected and mixed across grades. High modularity of lower grades suggests that assumptions of homogeneous mixing in epidemic models may be inappropriate; whereas lower modularity in high schools suggests that homogenous mixing assumptions may be more acceptable in these settings. The results suggest that interventions targeting subsets of classrooms may work better in elementary schools than high schools. Our work presents quantitative measures of age-specific, school-based contacts that can be used as the basis for constructing models of the transmission of infections in schools. PMID:26978780

  14. A digital resource model of the Upper Pennsylvanian Pittsburgh coal bed, Monongahela Group, northern Appalachian basin coal region, USA

    USGS Publications Warehouse

    Ruppert, L.F.; Tewalt, S.J.; Bragg, L.J.; Wallack, R.N.

    1999-01-01

    The U.S. Geological Survey is currently conducting a coal resource assessment of the coal beds and zones that are expected to provide the bulk of the Nation's coal resources for the next few decades. The Pittsburgh coal bed is the first bed in the northern and central Appalachian basin coal region to undergo a fully-digital assessment. The bed-specific assessment is being carried out in partnership with the state geologic surveys of West Virginia (WV), Pennsylvania (PA), Ohio (OH), and Maryland (MD). Comprehensive stratigraphic and geochemical databases have been developed for the Pittsburgh coal bed, and areal extent, mined areas, structure contour, isopach, overburden thickness maps of the bed have been released as United States Geological Survey (USGS) Open-File Reports. The resulting resource model indicates that of the original 34 billion short tons (31 billion tonnes) of Pittsburgh coal, 16 billion short tons (14 billion tonnes) remain. Although most of the remaining coal is thinner, deeper, and higher in ash and sulfur (S) than the original resource, there are blocks of extensive thick (6-8 ft or 1.8-2.4 m) coal in southwestern PA and the northern panhandle of WV.The U.S. Geological Survey is currently conducting a coal resource assessment of the coal beds and zones that are expected to provide the bulk of the Nation's coal resources for the next few decades. The Pittsburgh coal bed is the first bed in the northern and central Appalachian basin coal region to undergo a fully-digital assessment. The bed-specific assessment is being carried out in partnership with the state geologic surveys of West Virginia (WV), Pennsylvania (PA), Ohio (OH), and Maryland (MD). Comprehensive stratigraphic and geochemical databases have been developed for the Pittsburgh coal bed, and areal extent, mined areas, structure contour, isopach, overburden thickness maps of the bed have been released as United States Geological Survey (USGS) Open-File Reports. The resulting resource

  15. 9. Photocopy of original drawing belonging to the Pittsburgh Department ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. Photocopy of original drawing belonging to the Pittsburgh Department of Public Works, (n.d.). DRAWING NO. 1993: RECONSTRUCTION OF PORTALS, GENERAL PLAN & ELEVATION. - North Side Point Bridge, Spanning Allegheny River at Point of Pittsburgh, Pittsburgh, Allegheny County, PA

  16. PERSPECTIVE VIEW FROM NORTHWEST OF PITTSBURGH HIGH SCHOOL FOR THE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    PERSPECTIVE VIEW FROM NORTHWEST OF PITTSBURGH HIGH SCHOOL FOR THE CREATIVE AND PERFORMING ARTS, BUILT 2003 BY THE FIRM OF MACLACHLAN CORNELIUS AND FILONI. - Pittsburgh High School for the Creative & Performing Arts, 111 Ninth Street, Pittsburgh, Allegheny County, PA

  17. Emerald ash borer and the urban forest: Changes in landslide potential due to canopy loss scenarios in the City of Pittsburgh, PA.

    PubMed

    Pfeil-McCullough, Erin; Bain, Daniel J; Bergman, Jeffery; Crumrine, Danielle

    2015-12-01

    Emerald ash borer is expected to kill thousands of ash trees in the eastern U.S. This research develops tools to predict the effect of ash tree loss from the urban canopy on landslide susceptibility in Pittsburgh, PA. A spatial model was built using the SINMAP (Stability INdex MAPping) model coupled with spatially explicit scenarios of tree loss (0%, 25%, 50%, and 75% loss of ash trees from the canopy). Ash spatial distributions were estimated via Monte Carlo methods and available vegetation plot data. Ash trees are most prevalent on steeper slopes, likely due to urban development patterns. Therefore, ash loss disproportionately increases hillslope instability. A 75% loss of ash resulted in roughly 800 new potential landslide initiation locations. Sensitivity testing reveals that variations in rainfall rates, and friction angles produce minor changes to model results relative to the magnitude of parameter variation, but reveal high model sensitivity to soil density and root cohesion values. The model predictions demonstrate the importance of large canopy species to urban hillslope stability, particularly on steep slopes and in areas where soils tend to retain water. To improve instability predictions, better characterization of urban soils, particularly spatial patterns of compaction and species specific root cohesion is necessary. The modeling framework developed in this research will enhance assessment of changes in landslide risk due to tree mortality, improving our ability to design economically and ecologically sustainable urban systems. PMID:26245535

  18. Relationships between 700 hPa height anomalies and 1 April snowpack accumulations in the western USA

    USGS Publications Warehouse

    McCabe, G.J., Jr.; Legates, D.R.

    1995-01-01

    Relationships between atmospheric circulation and the temporal and spatial distribution of snowpack accumulations in the western USA are examined. In general, above-average snowpack accumulations are associated with negative 700 hPa height anomalies over the eastern North Pacific Ocean and the western USA. These anomalies are indicative of anomalous cyclonic circulation, which produces an anomalous westerly flow of moist air from the eastern North Pacific Ocean into the western USA and increases winter precipitation and snowpack accumulations. Below-average snowpack accumulations at most of the snowcourse stations are associated with positive 700 hPa anomalies over the western USA. -from Authors

  19. VIEW LOOKING NORTHEAST WITH OPEN HEARTH TO THE LEFT, PITTSBURGH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW LOOKING NORTHEAST WITH OPEN HEARTH TO THE LEFT, PITTSBURGH & LAKE ERIE RAILROAD TRACKS CENTER. - Pittsburgh Steel Company, Monessen Works, Open Hearth Plant, Donner Avenue, Monessen, Westmoreland County, PA

  20. Re-suspension of lead contaminated urban soil as a dominant source of atmospheric lead in Birmingham, Chicago, Detroit and Pittsburgh, USA

    NASA Astrophysics Data System (ADS)

    Laidlaw, Mark A. S.; Zahran, Sammy; Mielke, Howard W.; Taylor, Mark P.; Filippelli, Gabriel M.

    2012-03-01

    Soils in older areas of cities are highly contaminated by lead, due largely to past use of lead additives in gasoline, the use of lead in exterior paints, and industrial lead sources. Soils are not passive repositories and periodic re-suspension of fine lead contaminated soil dust particulates (or aerosols) may create seasonal variations of lead exposure for urban dwellers. Atmospheric soil and lead aerosol data from the Interagency Monitoring of Protected Visual Environments (IMPROVE) database were obtained for Pittsburgh (Pennsylvania), Detroit (Michigan), Chicago (Illinois), and Birmingham (Alabama), USA. In this study the temporal variations of atmospheric soil and lead aerosols in these four US cities were examined to determine whether re-suspended lead contaminated urban soil was the dominant source of atmospheric lead. Soil and lead-in-air concentrations were examined to ascertain whether lead aerosols follow seasonal patterns with highest concentrations during the summer and/or autumn. In addition, atmospheric soil and lead aerosol concentrations on weekends and Federal Government holidays were compared to weekdays to evaluate the possibility that automotive turbulence results in re-suspension of lead contaminated urban soil. The results show that the natural logs of atmospheric soil and lead aerosols were associated in Pittsburgh from April 2004 to July 2005 (R2 = 0.31, p < 0.01), Detroit from November 2003 to July 2005 (R2 = 0.49, p <0.01), Chicago from November 2003 to August 2005 (R2 = 0.32, p < 0.01), and Birmingham from May 2004 to December 2006 (R2 = 0.47, p < 0.01). Atmospheric soil and lead aerosols followed seasonal patterns with highest concentrations during the summer and/or autumn. Atmospheric soil and lead aerosols are 3.15 and 3.12 times higher, respectively, during weekdays than weekends and Federal Government holidays, suggesting that automotive traffic turbulence plays a significant role in re-suspension of contaminated roadside soils and

  1. 13. Photocopy of original drawing belonging to the Pittsburgh Department ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. Photocopy of original drawing belonging to the Pittsburgh Department of Public Works, (n.d.). DRAWING NO. 2000: ORNAMENTAL IRON & BRONZE DETAILS, UPPER PART OF PORTALS. - North Side Point Bridge, Spanning Allegheny River at Point of Pittsburgh, Pittsburgh, Allegheny County, PA

  2. 11. Photocopy of original drawing belonging to the Pittsburgh Department ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. Photocopy of original drawing belonging to the Pittsburgh Department of Public Works, (n.d.). DRAWING NO. 1998: ORNAMENTAL IRON & BRONZE DETAILS, LOWER PART OF PORTALS. - North Side Point Bridge, Spanning Allegheny River at Point of Pittsburgh, Pittsburgh, Allegheny County, PA

  3. 14. Photocopy of original drawing belonging to the Pittsburgh Department ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. Photocopy of original drawing belonging to the Pittsburgh Department of Public Works, (n.d.). DRAWING NO. 2001: ORNAMENTAL IRON & BRONZE, REAR ELEVATION OF PORTALS AND DETAILS. - North Side Point Bridge, Spanning Allegheny River at Point of Pittsburgh, Pittsburgh, Allegheny County, PA

  4. 12. Photocopy of original drawing belonging to the Pittsburgh Department ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. Photocopy of original drawing belonging to the Pittsburgh Department of Public Works, (n.d.). DRAWING NO. 1999: ORNAMENTAL IRON & BRONZE DETAILS, UPPER PART OF PORTALS. - North Side Point Bridge, Spanning Allegheny River at Point of Pittsburgh, Pittsburgh, Allegheny County, PA

  5. 15. Photocopy of original drawing belonging to the Pittsburgh Department ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    15. Photocopy of original drawing belonging to the Pittsburgh Department of Public Works, (n.d.). DRAWING NO. 2002: ORNAMENTAL IRON & BRONZE, LOCATION PLAN AND BRONZE TABLETS. - North Side Point Bridge, Spanning Allegheny River at Point of Pittsburgh, Pittsburgh, Allegheny County, PA

  6. 3. Photocopy of original drawing belonging to the Pittsburgh Department ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Photocopy of original drawing belonging to the Pittsburgh Department of Public Works, (n.d.). DRAWING NO. 1963: STRESS AND SECTION SHEET FOR 531' STEEL SPANS. - North Side Point Bridge, Spanning Allegheny River at Point of Pittsburgh, Pittsburgh, Allegheny County, PA

  7. 49 CFR 372.211 - Pittsburgh, PA.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... commerce, not under common control, management, or arrangement for a continuous carriage or shipment to or...) and (c) of this section, and (e) All of any municipality wholly surrounded, or so surrounded...

  8. Pittsburgh, Pennsylvania: Solar in Action (Brochure)

    SciTech Connect

    Not Available

    2011-10-01

    This brochure provides an overview of the challenges and successes of Pittsburgh, PA, a 2007 Solar America City awardee, on the path toward becoming a solar-powered community. Accomplishments, case studies, key lessons learned, and local resource information are given.

  9. Acid aerosols in the Pittsburgh Metropolitan area

    NASA Astrophysics Data System (ADS)

    McCurdy, Thomas; Zelenka, Michael P.; Lawrence, Philip M.; Houston, Robert M.; Burton, Robert

    This article presents data on ambient concentrations of selected acidic aerosols at four existing monitoring sites in the Pittsburgh PA metropolitan area. The data were collected by staff of the Allegheny County Health Department, Division of Air Quality during the summer and fall of 1993. The sampling protocol was focused on obtaining 24 h-average ammonia, ammonium, acidic sulfates, and particle strong acids data on a 2 to 3 day cycle. The data were obtained using Harvard University School of Public Health's "Short-HEADS" annular denuder sampling train. The Pittsburgh area is of interest because it is downwind of a major regional source of sulfur and nitrogen emissions from coal-burning power plants: the Ohio River Valley. The data presented here indicate that ground-level concentrations of acidic aerosols in Pittsburgh are highly correlated spatially and that many pollutants are higher on days when ground-level wind direction vectors indicate that wind is coming from the southwest rather than from the Pittsburgh source area itself. The monitoring site that is most upwind of the Pittsburgh source area - South Fayette - has particle strong acid levels about twice those of sites closer in to the Pittsburgh central business district.

  10. Immunology in Pittsburgh.

    PubMed

    Finn, Olivera J; Salter, Russell D

    2006-01-01

    The University of Pittsburgh School of Medicine has a long tradition of excellence in immunology research and training. Faculty, students, and postdoctoral fellows walk through hallways that are pictorial reminders of the days when Dr. Jonas Salk worked here to develop the polio vaccine, or when Dr. Niels Jerne chaired the Microbiology Department and worked on perfecting the Jerne Plaque Assay for antibody-producing cells. Colleagues and postdoctoral fellows of Professor Salk are still on the faculty of the University of Pittsburgh Medical School as are graduate students of Professor Jerne. A modern research building, the 17 story high Biomedical Science Tower, is a vivid reminder of the day when Dr. Thomas Starzl arrived in Pittsburgh and started building the most prominent solid-organ-transplant program in the world. The immunology research that developed around the problem of graft rejection and tolerance induction trained numerous outstanding students and fellows. Almost 20 yr ago, the University of Pittsburgh founded the University of Pittsburgh Cancer Institute (UPCI) with the renowned immunologist Dr. Ronald Herberman at its helm. This started a number of new research initiatives in cancer immunology and immunotherapy. A large number of outstanding young investigators, as well as several well-established tumor immunologists, were recruited to Pittsburgh at that time. PMID:17337760

  11. 77 FR 47671 - TA-W-81,520, T-Mobile USA, Inc., Call Center, Allentown, PA; TA-W-81,520G, T-Mobile USA, Inc...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-09

    ..., Inc., Bellevue, Washington. The Bellevue, Washington location provides human resources, and various... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF LABOR Employment and Training Administration TA-W-81,520, T-Mobile USA, Inc., Call Center, Allentown, PA; TA-...

  12. Longwall - USA: International exhibition & conference

    SciTech Connect

    1996-12-31

    The Longwall-USA International Exhibition and Conference was held June 4-6, 1996 in Pittsburgh, PA. Seventeen papers are included in the proceedings that covered such topics as health and safety, development of gate roads, telemetry monitoring systems, fires, longwall miners, roof support technologies, dust control, moving car bunker systems, reducing longwall noise, vibration of longwall equipment, and the USBM`s strategic structures testing laboratory. A separate abstract with indexing was prepared for each paper for inclusion in the Energy Science and Technology Database.

  13. Pittsburgh School Gets Energized.

    ERIC Educational Resources Information Center

    Hill, Willliam W.

    2002-01-01

    Describes a project designed to create an energy efficient high school in the diocese of Pittsburgh. The project will save over $850,000 in energy, operations, and maintenance costs over fifteen years. The design improves the physical premises as well by adding windows and eliminating fluorescent lighting. Offers tips for developing similar…

  14. Our Pittsburgh Constellation

    NASA Astrophysics Data System (ADS)

    Turnshek, Diane

    2015-08-01

    Riding on the Pittsburgh mayor’s keen interest in astronomy and the ongoing change of 40,000 city lights from mercury and sodium vapor to shielded LEDs, we organized a series of city-wide celestial art projects to bring attention to the skies over Pittsburgh. Light pollution public talks were held at the University of Pittsburgh’s Allegheny Observatory and other colleges. Earth Hour celebrations kicked off an intensive year of astronomy outreach in the city. Lights went out on March 28, 2015 from 8:30 to 9:30 pm in over fifty buildings downtown and in Oakland (the “Eds and Meds” center, where many Pittsburgh universities and hospitals are located). Our art contest was announced at the De-Light Pittsburgh celebration at the Carnegie Science Center during Astronomy Weekend. “Our Pittsburgh Constellation” is an interactive Google map of all things astronomical in the city. Different colored stars mark locations of planetariums, star parties, classes, observatories, lecture series, museums, telescope manufacturers and participating art galleries. Contest entrants submitted artwork depicting their vision of the constellation figure that incorporates and connects all the “stars” in our custom city map. Throughout the year, over a dozen artists ran workshops on painting star clusters, galaxies, nebulae, comets, planets and aurorae with discussions of light pollution solutions and scientific explanations of what the patrons were painting, including demonstrations with emission tubes and diffraction grating glasses. We will display the celestial art created in this International Year of Light at an art gallery as part of the City’s Department of Innovation & Performance March 2016 Earth Hour gala. We are thankful for the Astronomical Footprint grant from the Heinz Endowments, which allowed us to bring the worlds of science and art together to enact social change.

  15. Nutrition Education--1973. Part 7--School Nutrition Education Programs. Hearings Held Pittsburgh, Pa., May 25, 1973. Hearings Before the Select Committee on Nutrition and Human Needs of the United States Senate, Ninety-third Congress, First Session.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Select Committee on Nutrition and Human Needs.

    The following witnesses testified before these hearings of the Select Committee on Nutrition and Human Needs: Mrs. G. Marsh, area consultant, Division of Food and Nutrition Services, Pennsylvania Department of Education; Mrs. G. Chegwidden, director, School Food Service, Franklin Regional School District, Murrysville, Pa.; Mr. S. Lympany, senior…

  16. Proceedings of the Pittsburgh conference

    SciTech Connect

    Not Available

    1991-01-01

    These abstracts represent the state-of-the-art in Analytical Chemistry and Applied Spectroscopy and should be a valuable addition to your technical files. This volume is distributed only to the registrants of the 1991 Pittsburgh Conference and Exposition and therefore does not constitute a publication. This volume is not for sale nor does the Pittsburgh Conference permit abstraction of its contents.

  17. The Pittsburgh Sleep Diary

    NASA Technical Reports Server (NTRS)

    Monk, T. H.; Reynolds CF, 3. d.; Kupfer, D. J.; Buysse, D. J.; Coble, P. A.; Hayes, A. J.; Machen, M. A.; Petrie, S. R.; Ritenour, A. M.

    1994-01-01

    Increasingly, there is a need in both research and clinical practice to document and quantify sleep and waking behaviors in a comprehensive manner. The Pittsburgh Sleep Diary (PghSD) is an instrument with separate components to be completed at bedtime and waketime. Bedtime components relate to the events of the day preceding the sleep, waketime components to the sleep period just completed. Two-week PghSD data is presented from 234 different subjects, comprising 96 healthy young middle-aged controls, 37 older men, 44 older women, 29 young adult controls and 28 sleep disorders patients in order to demonstrate the usefulness, validity and reliability of various measures from the instrument. Comparisons are made with polysomnographic and actigraphic sleep measures, as well as personality and circadian type questionnaires. The instrument was shown to have sensitivity in detecting differences due to weekends, age, gender, personality and circadian type, and validity in agreeing with actigraphic estimates of sleep timing and quality. Over a 12-31 month delay, PghSD measures of both sleep timing and sleep quality showed correlations between 0.56 and 0.81 (n = 39, P < 0.001).

  18. 76 FR 27892 - Special Local Regulation; Allegheny River, Pittsburgh, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-13

    ...The Coast Guard is establishing a temporary special local regulation from the Point State Park (mile marker 0.0) to the River Rescue station (mile marker 0.5) on the Allegheny River, extending 200 feet out from the right descending bank. The special local regulation is being established to safeguard participants of the Venture Outdoors Festival from the hazards of marine traffic. Entry into,......

  19. Pittsburgh Adapts to Changing Times.

    ERIC Educational Resources Information Center

    States, Deidre

    1985-01-01

    The Samuel F. B. Morse School, built in 1874 and closed in 1980, is a historic landmark in Pittsburgh, Pennsylvania. Now the building serves as low-income housing for 70 elderly tenants and is praised as being an imaginative and creative use of an old school structure. (MLF)

  20. 77 FR 77016 - Foreign-Trade Zone 33 - Pittsburgh, Pennsylvania Notification of Proposed Export Production...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-31

    ... Export Production Activity Tsudis Chocolate Company (Chocolate Confectionery Bars) Pittsburgh, PA Tsudis Chocolate Company (Tsudis), an operator of FTZ 33, submitted a notification of proposed export production... production of chocolate confectionery bars for export (no shipments for U.S. consumption would occur)....

  1. Environmental Survey preliminary report, Pittsburgh Energy Technology Center, Pittsburgh, Pennsylvania

    SciTech Connect

    Not Available

    1988-09-01

    This report presents the preliminary findings from the first phase of the Environmental Survey of the US Department of Energy (DOE) Pittsburgh Energy Technology Center (PETC) conducted December 7--11, 1987. The Survey is being conducted by an interdisciplinary team of environmental specialists, led and managed by the Office of Environment, Safety and Health's Office of Environmental Audit. Individual team specialists are outside experts being supplied by a private contractor. The objective of the Survey is to identify environmental problems and areas of environmental risk associated with PETC. The Survey covers all environmental media and all areas of environmental regulation. It is being performed in accordance with the DOE Environmental Survey Manual. This phase of the Survey involves the review of existing site environmental data, observations of the operations carried on at PETC, and interviews with site personnel. The Survey team developed a Sampling and Analysis (S A) Plan to assist in further assessing certain environmental problems identified during its on-site Survey activities at PETC. The S A Plan will be executed by the Oak Ridge National Laboratory (ORNL). When completed, the Plan's results will be incorporated into the PETC Survey findings for inclusion into the Environmental Survey Summary Report. 64 refs., 23 figs., 29 tabs.

  2. Fulfilling The Pittsburgh Promise[R]: Early Progress of Pittsburgh's Postsecondary Scholarship Program. Monograph

    ERIC Educational Resources Information Center

    Gonzalez, Gabriella C.; Bozick, Robert; Tharp-Taylor, Shannah; Phillips, Andrea

    2011-01-01

    This report presents a detailed assessment of the extent to which "The Pittsburgh Promise"--a postsecondary education scholarship intended to remedy the area's population decline, foster high school completion and college readiness among Pittsburgh district students, and prepare a capable and energetic workforce for the city--has met its goals to…

  3. 75 FR 71721 - Pittsburgh Area Maritime Security Committee; Vacancies

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-24

    ... SECURITY Coast Guard Pittsburgh Area Maritime Security Committee; Vacancies AGENCY: Coast Guard, DHS... the Pittsburgh Area Maritime Security Committee to submit their application for membership, to the...-7324. SUPPLEMENTARY INFORMATION: Authority Section 102 of the Maritime Transportation Security...

  4. Pittsburgh Building "Nation" of 9th Graders

    ERIC Educational Resources Information Center

    Gewertz, Catherine

    2007-01-01

    Bitter experience has shown Pittsburgh, Pennsylvania, that if students are going to leave school, they are most likely to do it between the 8th and 9th grades. To combat that problem, the school district has launched a full-on campaign to get its rising freshmen into high school and keep them there. Two weeks before school opened, the district…

  5. University-Urban Interface Program. Pittsburgh Goals: Some Issues.

    ERIC Educational Resources Information Center

    Nehnevajsa, Jiri

    The Pittsburgh Goals Study about which this speech centers is SO 004 019. Issues identified by the leaders questioned which seem particularly crucial for the next five years in the development of Pittsburgh are: pollution control; public welfare system; drug problem; health services; low cost housing; rapid transit. Two more issues, Metropolitan…

  6. PORTAL ELEVATION, LOOKING SE. SINGLE BRIDGE IS PITTSBURGH, FORT WAYNE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    PORTAL ELEVATION, LOOKING SE. SINGLE BRIDGE IS PITTSBURGH, FORT WAYNE & CHICAGO RAILWAY; PAIR OF BRIDGES ARE ABANDONED LAKE SHORE AND MICHIGAN SOUTHERN RAILROAD (HAER No. IL-161). - Pittsburgh, Fort Wayne & Chicago Railway, Calumet River Bridge, Spanning Calumet River, east of Chicago Skyway (I-90), Chicago, Cook County, IL

  7. 7. PORTAL ELEVATION, LOOKING SE. SINGLE BRIDGE IS PITTSBURGH, FORT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. PORTAL ELEVATION, LOOKING SE. SINGLE BRIDGE IS PITTSBURGH, FORT WAYNE & CHICAGO RAILWAY; PAIR OF BRIDGES ARE ABANDONED LAKE SHORE AND MICHIGAN SOUTHERN RAILROAD (HAER No. IL-161). - Pittsburgh, Fort Wayne & Chicago Railway, Calumet River Bridge, Spanning Calumet River, east of Chicago Skyway (I-90), Chicago, Cook County, IL

  8. Value-Added Models for the Pittsburgh Public Schools

    ERIC Educational Resources Information Center

    Johnson, Matthew; Lipscomb, Stephen; Gill, Brian; Booker, Kevin; Bruch, Julie

    2012-01-01

    At the request of Pittsburgh Public Schools (PPS) and the Pittsburgh Federation of Teachers (PFT), Mathematica has developed value-added models (VAMs) that aim to estimate the contributions of individual teachers, teams of teachers, and schools to the achievement growth of their students. The authors' work in estimating value-added in Pittsburgh…

  9. Pittsburgh and the Arts or How My Eye Was Formed.

    ERIC Educational Resources Information Center

    Roschwalb, Susanne A.

    The way the author's experiences of the city of Pittsburgh (Pennsylvania) shaped her visual literacy are explored. Along with the imagery of the steel mills, she experienced some artistic opportunities that helped shape the foundation of her life in art. Although no American city was as extensively industrialized as Pittsburgh, it was the artistic…

  10. 75 FR 24961 - Pittsburgh Area Maritime Security Committee; Vacancies

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-06

    ... SECURITY Coast Guard Pittsburgh Area Maritime Security Committee; Vacancies AGENCY: Coast Guard, DHS... the Pittsburgh Area Maritime Security Committee (AMSC) to submit their application for membership, to... Security Act (MTSA) of 2002 (Pub. L. 107-295) added section 70112 to Title 46 of the U.S. Code,...

  11. Acid precipitation in the Pittsburgh, Pennsylvania area

    SciTech Connect

    Roffman, A.

    1980-03-01

    Studies on the pH of atmospheric precipitation are reviewed. The effects of acids in precipitation on aquatic and terrestrial ecosystems are summarized, with emphasis on the Pittsburgh area. Results of the pH content in the rain samples collected at the three stations in the Pittsburgh area between January 6, 1979 through February 18, 1979 are reported. Surprisingly, pH values of samples taken at Station 3, the rural, pollution-free station, were generally not higher, but rather frequently lower than those obtained in those stations considered polluted. The total mean of Station 1 was 4.3, the total mean of Station 2 was 4.2, and the total mean of Station 3 was 4.0. Wind data were obtained for the dates corresponding to the precipitation collection dates. On all of these dates, the maps show that the direction of the wind currents came from the Ohio River Valley Basin and blew in a northwest to southeast, west to east or a southwest to northeast direction. These winds could have carried pollution from this Basin and other areas in the Midwest into the southwestern Pennsylvania areas. Measurements show that all precipitation collection stations had a low pH at the time of the study. The industrial mills, along the Allegheny, Monogahela, and Ohio Rivers seem to have had a little or no effect on the low pH values measured at the closest station during the study period. The coal-burning power plants seem to have had an effect on the pH values of the precipitation samples collected at Station 3 during the course of the study.The data imply that pollution-carrying winds from the Ohio River Valley Basin contribute acidity to the three stations and Station 3 receives additional acidity from the surrounding coal-burning power plants.

  12. 76 FR 72673 - Foreign-Trade Zone 33-Pittsburgh, PA; Application for Reorganization/Expansion

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-25

    ... Order 124, 42 FR 59398, 11/17/77) and expanded on March 16, 1981 (Board Order 172, 46 FR 18063, 3/23/81), on May 14, 1998 (Board Order 981, 63 FR 29179, 5/28/98) and on February 23, 2010 (Board Order 1667, 75 FR 13488-13489, 3/22/10). The current zone project includes the following sites in the...

  13. Best Practices Case Study: S&A Homes, East Liberty, PIttsburgh, PA

    SciTech Connect

    2010-12-01

    S&A Homes worked with Building America's IBACOS and architects Pfaffmann & Associates and Moss Associates to design energy-efficient homes for urban in-fill lots. This is a new market for S&A Homes, which builds over 500 homes a year using suburban designs.

  14. POLLUTION PREVENTION OPPORTUNITY ASSESSMENT - U.S. POSTAL SERVICE POST OFFICES, PITTSBURGH, PA AREA

    EPA Science Inventory

    The United States Postal Service (USPS) in cooperation with EPA’s National Risk Management Research Laboratory (NRMRL) is engaged in an effort to integrate waste prevention and recycling activities into the waste management programs at Postal facilities. This report describ...

  15. Einstein's lecture in Pittsburgh, PA, December 1934: A note on further visual documentation

    NASA Astrophysics Data System (ADS)

    Topper, David; Vincent, Dwight

    2016-05-01

    Two newly discovered photographs of Einstein's 1934 lecture derivation of the energy-mass equivalence, popularly written as E = M c 2 , are analyzed for clues as to how the only visually documented blackboard lecture of his famous equation progressed. A previous analysis is supplemented with the new information.

  16. POLLUTION PREVENTION OPPORTUNITY ASSESSMENT UNITED STATES ARMY CORPS OF ENGINEERS PITTSBURGH ENGINEER WAREHOUSE AND REPAIR STATION AND EMSWORTH LOCKS AND DAMS PITTSBURGH, PENNSYLVANIA

    EPA Science Inventory

    This report summarizes work conducted at the United States Army Corps of Engineers (USACE) Pittsburgh Engineering Warehouse and Repair Station (PEWARS) and Emsworth Locks and Dams in Pittsburgh, Pennsylvania under the U.S. Environmental Protection Agency's (EPA's) Waste Reduction...

  17. Discovery of the gene signature for acute lung injury in patients with sepsis Address for reprint requests and other correspondence: J. A. Howrylak, UPMC Montefiore NW 628, 3459 5th Ave., Pittsburgh, PA 15213 (e-mail: howrylakj@upmc.edu).The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

    PubMed Central

    Howrylak, Judie A.; Dolinay, Tamas; Lucht, Lorrie; Wang, Zhaoxi; Christiani, David C.; Sethi, Jigme M.; Xing, Eric P.; Donahoe, Michael P.; Choi, Augustine M. K.

    2009-01-01

    The acute respiratory distress syndrome (ARDS)/acute lung injury (ALI) was described 30 yr ago, yet making a definitive diagnosis remains difficult. The identification of biomarkers obtained from peripheral blood could provide additional noninvasive means for diagnosis. To identify gene expression profiles that may be used to classify patients with ALI, 13 patients with ALI + sepsis and 20 patients with sepsis alone were recruited from the Medical Intensive Care Unit of the University of Pittsburgh Medical Center, and microarrays were performed on peripheral blood samples. Several classification algorithms were used to develop a gene signature for ALI from gene expression profiles. This signature was validated in an independently obtained set of patients with ALI + sepsis (n = 8) and sepsis alone (n = 1). An eight-gene expression profile was found to be associated with ALI. Internal validation found that the gene signature was able to distinguish patients with ALI + sepsis from patients with sepsis alone with 100% accuracy, corresponding to a sensitivity of 100%, a specificity of 100%, a positive predictive value of 100%, and a negative predictive value of 100%. In the independently obtained external validation set, the gene signature was able to distinguish patients with ALI + sepsis from patients with sepsis alone with 88.9% accuracy. The use of classification models to develop a gene signature from gene expression profiles provides a novel and accurate approach for classifying patients with ALI. PMID:19174476

  18. A Heat Vulnerability Index and Adaptation Solutions for Pittsburgh, Pennsylvania

    NASA Astrophysics Data System (ADS)

    Klima, K.; Abrahams, L.; Bradford, K.; Hegglin, M.

    2015-12-01

    With increasing evidence of global warming, many cities have focused attention on response plans to address their populations' vulnerabilities. Despite expected increased frequency and intensity of heat waves, the health impacts of such events in urban areas can be minimized with careful policy and economic investments. We focus on Pittsburgh, Pennsylvania and ask two questions. First, what are the top factors contributing to heat vulnerability and how do these characteristics manifest geospatially throughout Pittsburgh? Second, assuming the City wishes to deploy additional cooling centers, what placement will optimally address the vulnerability of the at risk populations? We use national census data, ArcGIS geospatial modeling, and statistical analysis to determine a range of heat vulnerability indices and optimal cooling center placement. We find that while different studies use different data and statistical calculations, all methods tested locate additional cooling centers at the confluence of the three rivers (Downtown), the northeast side of Pittsburgh (Shadyside/ Highland Park), and the southeast side of Pittsburgh (Squirrel Hill). This suggests that for Pittsburgh, a researcher could apply the same factor analysis procedure to compare datasets for different locations and times; factor analyses for heat vulnerability are more robust than previously thought.

  19. A Heat Vulnerability Index and Adaptation Solutions for Pittsburgh, Pennsylvania.

    PubMed

    Bradford, Kathryn; Abrahams, Leslie; Hegglin, Miriam; Klima, Kelly

    2015-10-01

    With increasing evidence of global warming, many cities have focused attention on response plans to address their populations' vulnerabilities. Despite expected increased frequency and intensity of heat waves, the health impacts of such events in urban areas can be minimized with careful policy and economic investments. We focus on Pittsburgh, Pennsylvania and ask two questions. First, what are the top factors contributing to heat vulnerability and how do these characteristics manifest geospatially throughout Pittsburgh? Second, assuming the City wishes to deploy additional cooling centers, what placement will optimally address the vulnerability of the at risk populations? We use national census data, ArcGIS geospatial modeling, and statistical analysis to determine a range of heat vulnerability indices and optimal cooling center placement. We find that while different studies use different data and statistical calculations, all methods tested locate additional cooling centers at the confluence of the three rivers (Downtown), the northeast side of Pittsburgh (Shadyside/Highland Park), and the southeast side of Pittsburgh (Squirrel Hill). This suggests that for Pittsburgh, a researcher could apply the same factor analysis procedure to compare data sets for different locations and times; factor analyses for heat vulnerability are more robust than previously thought. PMID:26333158

  20. Simplified Space Conditioning in Low-Load Homes: Results from Pittsburgh, Pennsylvania, New Construction Unoccupied Test House

    SciTech Connect

    Poerschke, Andrew; Stecher, Dave

    2014-06-01

    Field testing was performed in a new construction unoccupied test house in Pittsburgh, PA. Four air-based heating, ventilation, and air conditioning distribution systems—a typical airflow ducted system to the bedrooms, a low airflow ducted system to the bedrooms, a system with transfer fans to the bedrooms, and a system with no ductwork to the bedrooms—were evaluated during heating, cooling, and midseason conditions. The relative ability of each system was assessed with respect to relevant Air Conditioning Contractors of America and ASHRAE standards for house temperature uniformity and stability, respectively.

  1. Time of travel of water in the Ohio River, Pittsburgh to Cincinnati

    USGS Publications Warehouse

    Steacy, Robert E.

    1961-01-01

    This report presents a procedure for estimating the time of travel of water in the Ohio River from Pittsburgh, Pa., to Cincinnati, Ohio, under various river stage conditions. This information is primarily for use by civil defense officials and by others concerned with problems involving travel time of river water. Tables and charts are presented to show, for a particular stage or discharge at Cincinnati, the average time it would take for water to travel through the entire reach from Pittsburgh, or through successive intermediate segments of the reach. For example, when the discharge at Cincinnati is 200,000 cfs, travel time from Pittsburgh to Cincinnati, a distance of 470 miles, averages about 7 days; and for discharges of more than 200,000 cfs, the travel time decreases very slowly with increasing discharge. When the discharge is 30,000 cfs, travel time is about 28 days; and for discharges of less than 30,000 cfs, the travel time increases very rapidly with decreasing discharge. Estimates of travel time at low discharge are subject to large errors. Statistical analysis of the possible variations of upstream discharge for a given discharge at Cincinnati indicates that the shortest probable travel time from Pittsburgh to Cincinnati ranges from 56 percent of that under average conditions when the discharge at Cincinnati is 15,000 cfs to 93 percent of that under average conditions when the discharge at Cincinnati is 894,000 cfs. A chart showing the time distribution of flow at Cincinnati is presented so that the probable travel time of Ohio River water can be determined for any time of the year. This chart provides information which, when applied to the time-of-travel chart, shows that the most probable travel time of water from Pittsburgh to Cincinnati ranges from 160 hours in February to 1,250 hours in September. Also presented is a flow-duration curve that can be used to predict future discharges and, subsequently, times of travel, for use in long-range planning

  2. Preparing for Local Adaptation: Understanding Flood Risk Perceptions in Pittsburgh

    NASA Astrophysics Data System (ADS)

    Klima, K.; Wong-Parodi, G.

    2015-12-01

    The City of Pittsburgh experiences numerous floods every year. Aging and insufficient infrastructure contribute to flash floods and to over 20 billion gallons of combined sewer overflows annually, contaminating Pittsburgh's streets, basements, and waterways. Climate change is expected to further exacerbate this problem by causing more intense and more frequent extreme precipitation events in Western Pennsylvania. For a stormwater adaptation plan to be implemented effectively, the City will need informed public support. One way to achieve public understanding and support is through effective communication of the risks, benefits, and uncertainties of local flooding hazards and adaptation methods. In order to develop these communications effectively, the city and its partners will need to know what knowledge and attitudes the residents of Pittsburgh already hold about flood risks. Here we seek to (1) identify Pittsburgh residents' knowledge level, risk perception and attitudes towards flooding and storm water management, and (2) pre-test communications meant to inform and empower Pittsburghers about flood risks and adaptation strategies. We conduct a city-wide survey of 10,000 Pittsburgh renters and homeowners from four life situations: high risk, above poverty; high-risk, below poverty; low risk, above poverty; and low-risk, below poverty. Mixed media recruitment strategies (online and paper-based solicitations guided/organized by community organizations) assist in reaching all subpopulations. Preliminary results suggest participants know what stormwater runoff is, but have a weak understanding of how stormwater interacts with natural and built systems. Furthermore, although participants have a good understanding of the difference between green and gray infrastructure, this does not translate into a change in their willingness to pay for green infrastructure adaptation. This suggests additional communications about flood risks and adaptation strategies.

  3. An Evaluation of the Pittsburgh Reading is FUNdamental Program.

    ERIC Educational Resources Information Center

    Boldovici, John A.; And Others

    A study of one of the model "Reading is FUNdamental" (RIF) programs located in Pittsburgh, Pennsylvania, was made to determine the success of the program and to formulate suggestions for changes. RIF is a program in which free or inexpensive books are made available in a community through schools, libraries, and other local organizations in order…

  4. The Pittsburgh Project - Part I: Community Growth and Survival.

    ERIC Educational Resources Information Center

    Taylor, Jerome

    This paper presents a summary of the first part of the Pittsburgh Project. It deals with white racialism. "Racialism" is a term that is used differently, explained differently, and deployed differently to account for a heterogeneous range of social phenomena. Not uncommonly, assumptions are made that racialism is a unitary rather than a…

  5. 75 FR 9867 - University of Pittsburgh, et al

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-04

    .... Instrument: Electron Microscope. Manufacturer: JEOL, Ltd., Japan. Intended Use: See notice at 75 FR 3895...: JEM-1400 Electron Microscope. Manufacturer: JEOL Ltd., Japan. Intended Use: See notice at 75 FR 3895... International Trade Administration University of Pittsburgh, et al.; Notice of Consolidated Decision...

  6. Hungarian Community Life in Greater Pittsburgh. Educational Curriculum Kit 4.

    ERIC Educational Resources Information Center

    Boros-Kazai, Mary; Body, Paul

    This booklet is a guide to Hungarian American churches, organizations, and events in Pittsburgh and western Pennsylvania. In addition to listings of organizations and events, names of contact persons, their addresses and telephone numbers are provided. Information is furnished on: (1) Hungarian religious organizations; (2) social and cultural…

  7. The "Pittsburgh Courier's" Double V Campaign in 1942.

    ERIC Educational Resources Information Center

    Washburn, Pat

    In February 1942, a letter to the editor of the Pittsburgh "Courier," the nation's largest black owned newspaper, started the "Double V" (for victory at home and victory abroad) campaign, which stressed the right of blacks to have equality in the United States since they were fighting inequality abroad. As the "Courier" devoted a great deal of…

  8. The Pittsburgh Girls Study: Overview and Initial Findings

    ERIC Educational Resources Information Center

    Keenan, Kate; Hipwell, Alison; Chung, Tammy; Stepp, Stephanie; Stouthamer-Loeber, Magda; Loeber, Rolf; McTigue, Kathleen

    2010-01-01

    The Pittsburgh Girls Study is a longitudinal, community-based study of 2,451 girls who were initially recruited when they were between the ages of 5 and 8 years. The primary aim of the study was testing developmental models of conduct disorder, major depressive disorder, and their co-occurrence in girls. In the current article, we summarize the…

  9. Bettis Atomic Power Laboratory. Bettis-Pittsburgh Site environmental summary report

    SciTech Connect

    2000-08-01

    This summary report provides a description of the nature and environmental aspects of work and facilities at the Bettis-Pittsburgh site, an historical perspective of Bettis-Pittsburgh operations that is not provided by the annual reports, and background information pertinent to understanding the environmental aspects of Bettis-Pittsburgh operations.

  10. The Pittsburgh Promise: A Community's Commitment to Its Young People

    ERIC Educational Resources Information Center

    Ghubril, Saleem

    2013-01-01

    The nonprofit community-based organization Pittsburgh Promise aims to help revitalize Pittsburgh and its public school system by offering college scholarships to any Pittsburgh Public School graduate who meets the academic requirements. Executive director Saleem Ghubril spoke with "Voices in Urban Education" guest editor Jacob Mishook…

  11. Physician Assistant profession (PA)

    MedlinePlus

    ... provide health care services under the direction and supervision of a doctor of medicine (MD) or a ... location as the PA. Most states allow physician supervision by telephone communication with periodic site visits. Supervising ...

  12. Physician Assistant profession (PA)

    MedlinePlus

    ... and about 4 years of health-related experience. Educational programs for PAs are typically associated with colleges of medicine. They vary from 25 to 27 months in length. Most programs award a master's degree upon completion. The first PA students were ...

  13. The Pittsburgh Fatigability Scale for Older Adults: Development and Validation

    PubMed Central

    Glynn, Nancy W.; Santanasto, Adam J.; Simonsick, Eleanor M.; Boudreau, Robert M.; Beach, Scott R.; Schulz, Richard; Newman, Anne B.

    2016-01-01

    OBJECTIVES To describe the development of the Pittsburgh Fatigability Scale (PFS) and establish its reliability and concurrent and convergent validity against performance measures. DESIGN Cross-sectional. SETTING University of Pittsburgh, Pittsburgh, Pennsylvania. PARTICIPANTS Scale development sample: 1,013 individuals aged 60 and older from two registries; validation sample: 483 adults aged 60 and older from the Baltimore Longitudinal Study of Aging (BLSA). MEASUREMENTS The scale development sample and BLSA participants self-administered an initial 26-item perceived fatigability scale. BLSA participants also completed measures of performance fatigability (perceived exertion from a standard treadmill task and performance deterioration from a fast-paced long-distance corridor walk), a 6-m usual-paced corridor walk, and five timed chair stands. RESULTS Principal components analysis with varimax rotation reduced the 26-item scale to the 10-item PFS. The PFS showed strong internal consistency (Cronbach’s alpha 0.88) and excellent test–retest reliability (intraclass correlation 0.86). In the validation sample, PFS scores, adjusted for age, sex, and race, were greater for those with high performance fatigability, slow gait speed, worse physical function, and lower fitness, with differences between high and low fatigability ranging from 3.2 to 5.1 points (P < .001). CONCLUSION The 10-item PFS physical fatigability score is a valid and reliable measure of perceived fatigability in older adults and can serve as an adjunct to performance- based fatigability measures for identifying older adults at risk of mobility limitation in clinical and research settings. PMID:25556993

  14. Abstracts of Papers Presented at the 2005 Pittsburgh Conference

    PubMed Central

    Stockwell, Peter B.

    2005-01-01

    To attend or not to attend, that is the question. The Pittsburgh Conference continues to pose this conundrum to conferees and exhibitors alike. This year's conference was the first to be presented without a set of paper abstracts—a good thing some would say but this old codger always used the paper abstracts to select papers of interest to our readership and to seek a full publication. The exhibit took its usual format but it seemed that there were less manufacturers present. The information presented to the attendees was also lacking and many companies' details were missing from the final program book, an omission no doubt on their behalf—my company was one of these—however I feel sure that past Pittcon organizers would have been more persistent in getting the required details for the audience. As is now the norm, many of the presentations take the form of posters displayed within the exhibition area. Without a driver to get the audience there, the traffic was slow, to say the least. Lecture presentations were also attended in a mixed fashion. So the Pittsburgh Conference show moves on, and again next year it will be held in Orlando from 12 March to 17 March 2006. No doubt I will be there making it a straight 31 in a row; in Pittsburgh Conference terms I am just a beginner with many of the attendees making more shows in a run than that. Selected abstracts dealing with topics of interest to the readers of this journal follow—hopefully many of these groups will be willing to publish their work either within this journal or elsewhere. PMID:18924631

  15. Clinical event monitoring at the University of Pittsburgh.

    PubMed Central

    Wagner, M. M.; Pankaskie, M.; Hogan, W.; Tsui, F. C.; Eisenstadt, S. A.; Rodriguez, E.; Vries, J. K.

    1997-01-01

    Although the literature on event monitoring is extensive, it does not cover all issues that we encountered while developing an event monitor at our institution. We had to resolve issues related to event detection, scalability, what topics were suitable for asynchronous decision support, and overlap of efforts of other groups at the institution attempting to improve quality and lower cost of care. In this paper, we describe our experience deploying CLEM, the clinical event monitor at the University of Pittsburgh with emphasis on these topics. PMID:9357614

  16. Preliminary results from the Pittsburgh Air Quality Study

    NASA Astrophysics Data System (ADS)

    Pandis, S. N.; Davidson, C. I.; Robinson, A. L.; Khlystov, A. Y.

    2002-12-01

    The Pittsburgh Air Quality Study (PAQS) is a collaborative effort among 20 research groups, and is part of the EPA Supersite Program. In collaboration with several other Supersites around the country, PAQS is also one component of an intensive experiment conducted in July 2001. The PAQS study includes monitoring for aerosol number, surface, and volume distributions, PM mass in several size ranges, single particle chemical composition, continuous aerosol sulfate, nitrate, and carbon mass, bioaerosols, hygroscopic aerosol growth, and filter-based aerosol chemical composition including trace metals, anions/cations, elemental and organic carbon, and various organic compounds. Meteorological data and concentrations of several trace gases are obtained simultaneously. The results will be used to test a variety of hypothesis on atmospheric aerosols. Examples include our ability to account for aerosol mass by summing contributions of individual chemical species, the extent to which single particle chemical composition data can be used to determine bulk chemical concentrations, our ability to predict natural and anthropogenic sources of aerosols, and the extent to which aerosols contribute to increased morbidity and mortality in Pittsburgh. This paper summarizes a few of the interesting results obtained during the study, such as closure of the aerosol mass balance, frequent new particle formation, aerosol water content and artifacts when sampling carbonaceous aerosol.

  17. Cofiring Wood and Coal to Stoker Boilers in Pittsburgh

    SciTech Connect

    Cobb, J.T., Jr.; Elder, W.W.

    1997-07-01

    The prime objective of the University of Pittsburgh's overall wood/coal cofiring program is the successful introduction of commercial cofiring of urban wood wastes into the stoker boilers of western Pennsylvania. Central to this objective is the demonstration test at the Pittsburgh Brewing Company. In this test the project team is working to show that two commercially-available clean wood wastes - tub-ground pallet waste and chipped clearance wood - can be included in the fuel fed daily to an industrial stoker boiler. Irrespective of its economic outcome, the technical success of the demonstration at the brewery will allow the local air quality regulation agency to permit a parametric test at the Bellefield Boiler Plant. The objective of this test is to obtain comprehensive data on all key parameters of this operational boiler while firing wood with coal. The data would then be used for thorough generic technical and economic analyses. The technical analysis would be added to the open literature for the general planning and operational guidance for boiler owners and operators. The economic analysis would gage the potential for providing this stoker fuel commercially in an urban setting and for purchasing it regularly for combustion in an urban stoker boiler.

  18. Superalloy 718: Metallurgy and applications; Proceedings of the International Symposium, Pittsburgh, PA, June 12-14, 1989

    SciTech Connect

    Loria, E.A.

    1989-01-01

    Recent advances in the metallurgy and applications of superalloy 718 (S718) are examined in reviews and reports. Topics addressed include melting technology for S718, solidification control in VAR and ESR S718 ingots, application of a modified phase diagram to the production of cast S718 components, microstructural characterization of cast S718, the hot deformation behavior of as-cast S718 ingots, and the effects of starting condition on the aging response of as-forged S718. Consideration is given to the long-term stability of a wrought S718 disk, P/M S718 tubing produced by cold radial forging, laser cladding of Astroloy on S718, the mechanical properties and microstructure of fine-grain centrifugally cast S718, the phase stability and aging response of TiC-reinforced S718, and the analysis and elimination of time-dependent notch sensitivity in S718.

  19. 1989 American Control Conference, 8th, Pittsburgh, PA, June 21-23, 1989, Proceedings. Volumes 1, 2, 3

    SciTech Connect

    Not Available

    1989-01-01

    Papers are presented on such topics as the robust control of robotic manipulators, aircraft control, intelligent control systems, computer networking for real-time control, robust adaptive control, and nonlinear process control. Consideration is also given to advances in distributed detection, control issues for large flexible manipulators, aerospace guidance and control, optimization in biochemical engineering, advanced robotics, fuzzy logic and process control, vibration control, and special architectures in real-time control systems.

  20. Annual Conference on Magnetism and Magnetic Materials, 29th, Pittsburgh, PA, November 8-11, 1983, Proceedings

    SciTech Connect

    Hasegawa, R.; Koon, N.C.; Cooper, B.R.

    1984-03-15

    Various topics on magnetism and magnetic materials are addressed. The subjects considered include: spin glasses, amorphous magnetism, actinide and rare earth intermetallics, magnetic excitation, itinerant magnetism and magnetic structure, valence instabilities, Kondo effect, transport and Hall effects, mixed valence and Kondo compounds, superconductivity and magnetism, d and f electron magnetism and superconductivity, Fe-based microcrystalline and permanent magnetic alloys, hard and soft magnetic materials, and magnetooptics. Also discussed are: numerical methods for magnetic field computation, recording theory and experiments, recording heads and media, magnetic studies via hyperfine interactions, magnetic semiconductors, magnet insulators, transition metal systems, random fields, critical phenomena and magnetoelastic effects and resonance, surfaces and interfaces, magnetostatic waves and resonance, bubble materials and implantation, bubble devices and physics, magnetic separation, ferrofluids, magnetochemistry, new techniques and materials, and new applications.

  1. Improving School Leadership through Support, Evaluation, and Incentives: The Pittsburgh Principal Incentive Program. Monograph

    ERIC Educational Resources Information Center

    Hamilton, Laura S.; Engberg, John; Steiner, Elizabeth D.; Nelson, Catherine Awsumb; Yuan, Kun

    2012-01-01

    In 2007, the Pittsburgh Public Schools (PPS) received funding from the U.S. Department of Education's Teacher Incentive Fund (TIF) program to implement the Pittsburgh Urban Leadership System for Excellence (PULSE), a set of reforms designed to improve the quality of school leadership throughout the district. A major component of PULSE is the…

  2. Professors at U. of Pittsburgh Called Managers, Ruled Ineligible to Bargain.

    ERIC Educational Resources Information Center

    Heller, Scott

    1987-01-01

    Full-time professors at the University of Pittsburgh enjoy "real managerial authority" and cannot bargain collectively under state law, a Pennsylvania Labor Relations Board examiner has ruled. The examiner said Pittsburgh's faculty members could not bargain because they enjoyed similar working conditions to professors at Yeshiva University. (MLW)

  3. Psychometric Analysis of the Pittsburgh Insomnia Rating Scale among University Population of Poor Sleepers in India

    PubMed Central

    Veqar, Zubia; Moiz, Jamal Ali; Hussain, Mohammed Ejaz

    2014-01-01

    Background: Pittsburgh insomnia rating scale is a 65 item self administered open source questionnaire. The scale is widely used in clinical practice but its psychometric properties are not well established. Therefore keeping in mind this lacuna the current study was designed for university population of poor sleepers in India. Aims: The purpose of this study was to establish the Pittsburgh sleep Quality Index test- retest reliability, validity and internal consistency of Pittsburgh insomnia rating scale. Materials and Methods: Twenty five subjects were randomly chosen from the screened population of poor sleepers. Pittsburgh insomnia rating scale, Pittsburgh sleep quality index and Insomnia severity index were administered on test day. Retest was administered after one week. Results: Eight males and seventeen females with mean age 24 + 7.04 were recruited. The test retest reliability for Pittsburgh insomnia rating scale total score showed excellent reliability (ICC2,1-0.93). The results also show that the total score is moderately correlated with Pittsburgh sleep Quality Index (r-0.31) and moderately correlated with Insomnia severity index (r-0.49). Internal consistency for the test was excellent (Cronbach's alpha- 0.930) Conclusion: The study findings suggest that Pittsburgh insomnia rating scale has excellent internal consistency, test-retest reliability and good validity for university population of poor sleepers in India. It is an important first line of assessment scale for screening of sleep problems. PMID:24843848

  4. Equal Employment Opportunity on Campus: A Case Study of the University of Pittsburgh.

    ERIC Educational Resources Information Center

    Blakely, Edward J.

    In November 1970, the University of Pittsburgh submitted an affirmative action plan to the Department of Health, Education, and Welfare. The plan was modified and expanded the following year and, with HEW urging, it became a model program adopted by many colleges. However, in the next several years the University of Pittsburgh learned, as many…

  5. The Impact of The University of Pittsburgh on the Local Economy.

    ERIC Educational Resources Information Center

    Pittsburgh Univ., PA. University Urban Interface Program.

    One of the projects selected for the University Urban Interface Program at the University of Pittsburgh was that of studying the impact of the university on the city of Pittsburgh. In pursuing this goal, studies were made of university-related local business volume; value of local business property committed to university-related business; credit…

  6. Guide to Historic Hungarian Places in Greater Pittsburgh. Educational Curriculum Kit 3.

    ERIC Educational Resources Information Center

    Boros-Kazai, Andrew

    This booklet is a guide to buildings and other sites which have played a significant role in the history of the Hungarian community in Pittsburgh (Pennsylvania). A brief summary of the significance or present use is provided for: (1) the Hungarian Nationality room at the University of Pittsburgh's Cathedral of Learning; (2) special collections of…

  7. An organizational survey of the Pittsburgh Energy Technology Center

    SciTech Connect

    Stock, D.A.; Shurberg, D.A.; Haber, S.B.

    1991-09-01

    An Organizational Survey (OS) was administrated at the Pittsburgh Energy Technology Center (PETC) that queried employees on the subjects of organizational culture, various aspects of communications, employee commitment, work group cohesion, coordination of work, environmental, safety, and health concerns, hazardous nature of work, safety and overall job satisfaction. The purpose of the OS is to measure in a quantitative and objective way the notion of ``culture``; that is, the values attitudes, and beliefs of the individuals working within the organization. In addition, through the OS, a broad sample of individuals can be reached that would probably not be interviewed or observed during the course of a typical assessment. The OS also provides a descriptive profile of the organization at one point in time that can then be compared to a profile taken at a different point in time to assess changes in the culture of the organization.

  8. An organizational survey of the Pittsburgh Energy Technology Center

    SciTech Connect

    Stock, D.A.; Shurberg, D.A.; Haber, S.B.

    1991-09-01

    An Organizational Survey (OS) was administrated at the Pittsburgh Energy Technology Center (PETC) that queried employees on the subjects of organizational culture, various aspects of communications, employee commitment, work group cohesion, coordination of work, environmental, safety, and health concerns, hazardous nature of work, safety and overall job satisfaction. The purpose of the OS is to measure in a quantitative and objective way the notion of culture''; that is, the values attitudes, and beliefs of the individuals working within the organization. In addition, through the OS, a broad sample of individuals can be reached that would probably not be interviewed or observed during the course of a typical assessment. The OS also provides a descriptive profile of the organization at one point in time that can then be compared to a profile taken at a different point in time to assess changes in the culture of the organization.

  9. Aging and space flight: findings from the University of Pittsburgh

    NASA Technical Reports Server (NTRS)

    Monk, T. H.

    1999-01-01

    For more than a decade, the Sleep and Chronobiology Center (SCC) at the University of Pittsburgh has received funding from the National Institute on Aging (NIA), the National Institute of Mental Health (NIMH) and the National Aeronautics and Space Administration (NASA) in order to study the sleep and circadian rhythms of healthy older people, as well as the sleep and circadian rhythms of astronauts and cosmonauts. We have always been struck by the strong synergism between the two endeavors. What happens to the sleep and circadian rhythms of people removed from the terrestrial time cues of Earth is in many ways similar to what happens to people who are advancing in years. Most obviously, sleep is shorter and sleep depth is reduced, but there are also more subtle similarities between the two situations, both in circadian rhythms and in sleep, and in the adaptive strategies needed to enhance 24h zeitgebers.

  10. The Pittsburgh Girls Studies: Overview and Initial Findings

    PubMed Central

    Keenan, Kate; Hipwell, Alison; Chung, Tammy; Stepp, Stephanie; Stouthamer-Loeber, Magda; Loeber, Rolf; McTigue, Kathleen

    2010-01-01

    The Pittsburgh Girls Study is a longitudinal, community–based study of 2,451 girls who were initially recruited when they were between the ages of 5 and 8 years. The primary aim of the study was testing developmental models of conduct disorder (CD), major depressive disorder (MDD), and their co-occurrence in girls. In the current paper, we summarize the published findings from the past 5 years of the PGS and place those results in the context of what it known to date about developmental psychopathology in girls. Key results suggest that DSM-IV mental disorders tend to have an insidious onset often beginning with sub-syndromal symptom manifestation and that there appear to be shared and unique developmental precursors to disorder in subgroups of girls based on race and poverty. PMID:20589562

  11. Pneumonia caused by Pittsburgh pneumonia agent: radiologic manifestations

    SciTech Connect

    Muder, R.R.; Reddy, S.C.; Yu, V.L.; Kroboth, F.J.

    1984-03-01

    Using an objective scoring system, chest radiographs were reviewed in 23 cases of pneumonia due to the Pittsburgh pneumonia agent (PPA, Tatlockia micdadei, Legionella micdadei), including six cases of pneumonia with simultaneous isolation of PPA and L pneumophila (Legionnaires' disease). Infiltrates were typically segmental to lobar; nodular infiltrates were noted in three cases. Spread to additional lobes after presentation occurred in four of 17 PPA infections. Pneumonia caused by both PPA and L pneumophila was unusually severe, with involvement of all lobes occurring in four of six cases, compared with one of 17 cases of PPA infection (p>0.02). Radiographic severity did not correlate with underlying disease, immune status, or outcome. The majority of patients receiving erythromycin demonstrated objective radiologic improvement. In a patients, population that included nonimmunosuppressed patient, nodule formation and rapid radiologic progression were not found to be characteristic of PPA pneumonia.

  12. Lighting retrofits at the Pittsburgh Zoo and Aviary

    SciTech Connect

    Sadowski, E.C.

    1995-09-01

    The Pittsburgh Zoo occupies approximately 52 acres in the City`s Highland Park. Thirty structures serve as animal holding facilities, public display buildings, classrooms, food service facilities, offices, warehouses, a veterinary hospital, and gift shops. The cost of energy for heating, cooling, lighting, pumping, food service, etc. is approximately $280,000 a year. Of this, about 79 percent, or $220,000, is spent for electricity. About 20 percent ($44,000) of that electricity cost is spent directly on lighting. In mid-1992 a series of retrofits to the lighting systems in the Zoo`s buildings was begun. These were completed in mid-1994. These improvements cost $127,690, and they are expected to reduce electricity costs by $24,500 a year. The most interesting projects were carried out in the Tropical Forest Building, the Aqua Zoo, and the Niches of the World Building.

  13. Lighting retrofits at the Pittsburgh Zoo and Aviary

    SciTech Connect

    Sadowski, E.C.

    1995-06-01

    Energy bills for the Pittsburgh Zoo typically total $280,000 a year, of which about $220,000 are spent on electricity. Until recently, lighting accounted for 20 percent of this electricity use. This translated into an annual cost of $44,000. Recent advances in lighting technology have made it possible to perform lighting retrofits in Zoo facilities that reduce energy costs while also providing improved light quality and better lit and more natural looking exhibits and animal holding areas. Through an investment of $127,690 in these projects from mid-1992 through mid-1994, the Zoo expects to realize an annual savings in electricity costs of $24,500 and further savings from a reduction in maintenance and plant replacement costs. Retrofits to the lighting systems in the Tropical Forest Building, the Aquarium, and the Niches of the World Building were the most interesting and are described in detail. Providing a sufficient amount of ultraviolet light to maintain the health of reptiles was a particular challenge in the Niches of the World Building. Lack of separate meters and additions to the Zoo have made the determination of the actual performance of these retrofit projects impossible. A similar retrofit project at the Pittsburgh Aviary (now the National Aviary) in 1989 through 1990 provides savings figures that should be comparable to those expected at the Zoo, however. This project cost $100,000 and saved $21,008 in electricity costs during the first year of operation. Maintenance costs were reduced by approximately $5000 a year.

  14. IDENTIFYING A SUSCEPTIBLE SUBGROUP: EFFECTS OF THE PITTSBURGH AIR POLLUTION EPISODE UPON SCHOOL CHILDREN

    EPA Science Inventory

    Pulmonary function test results on 224 parochial schoolchildren collected during and after the Pittsburgh air pollution episode of November 1975 were reanalyzed to determine whether a small subgroup of susceptible children could be defined. Individual regressions of three-quarter...

  15. Smoky ol' town: the significance of Pittsburgh in U.S. air pollution history

    SciTech Connect

    James Longhurst

    2007-06-15

    Pittsburgh came to be - and came to be dirtybecause of location, location, and location. Two navigable rivers met in the middle of a forest, and combined to form a third river. This was an irresistible meeting point for settlement, trade, and industry. It was an added bonus that this meeting point was at the center of the 'Pittsburgh seam' of coal. While the natural advantages of geography and geology initiated development, Pittsburgh's growth soon attracted man-made transportation networks to import resources from its hinterland and spread finished materials through the Midwest. As the city boomed into an industrial metropolis - the Iron City, the Steel City - through the late 19th and early 20th centuries, the smoke only became worse, and Pittsburgh became known, nationally and even internationally, for its dirt, grime, and filth. For many of the city's workers and businessmen, smoke was a sign of progress and economic success. From small-scale iron production, to the process of refining coal into 'coke,' to the Bessemer steel process, to J.P. Morgan and Andrew Carnegie's creation of the vertically-integrated U.S. Steel corporation, to the pioneering use of 'byproduct' coke ovens, Pittsburgh was home to successive technologies for transforming raw materials into finished or refined goods. Pittsburgh is both singular and representative; its story is at the forefront of pollution history, but the forces, trends, and events the city witnessed were the same in many cities across the nation. So while it is true that A&WMA's headquarters are in Pittsburgh for a reason, it is also true that its membership is spread across the nation and the world. That membership will most likely find something in these four themes from Pittsburgh's history that is representative of their own study. 7 refs., 3 photos.

  16. PaR-PaR Laboratory Automation Platform

    SciTech Connect

    Linshiz, G; Stawski, N; Poust, S; Bi, CH; Keasling, JD; Hilson, NJ

    2013-05-01

    Labor-intensive multistep biological tasks, such as the construction and cloning of DNA molecules, are prime candidates for laboratory automation. Flexible and biology-friendly operation of robotic equipment is key to its successful integration in biological laboratories, and the efforts required to operate a robot must be much smaller than the alternative manual lab work. To achieve these goals, a simple high-level biology-friendly robot programming language is needed. We have developed and experimentally validated such a language: Programming a Robot (PaR-PaR). The syntax and compiler for the language are based on computer science principles and a deep understanding of biological workflows. PaR-PaR allows researchers to use liquid-handling robots effectively, enabling experiments that would not have been considered previously. After minimal training, a biologist can independently write complicated protocols for a robot within an hour. Adoption of PaR-PaR as a standard cross-platform language would enable hand-written or software-generated robotic protocols to be shared across laboratories.

  17. Northern and Central Appalachian region assessment: The Pittsburgh coal bed

    SciTech Connect

    Ruppert, L.; Tewalt, S.; Bragg, L.

    1996-12-31

    Approximately 40% of the Nation`s coal is produced in the six states (Ohio, Pennsylvania, West Virginia, Maryland, Virginia, and Kentucky) that occupy parts of the Northern and Central Appalachian region. Coal is, and will continue to be, the primary energy commodity in this region where more than 50 coal beds and coal zones are currently being mined. About one-half of the productions is from just eight coal beds or zones. Three of these, the Pittsburgh and Upper Freeport coal beds and the Kittanning coal zone, are located in the northern part of the region. The remaining beds or zones, the Pond Creek, Fire Clay, Alma, Upper Elkhorn No. 3, and the Pocahontas No. 3, are located primarily in the central part of the region. This study is designed to utilize the data and expertise existing within the USGS and the State Geological Surveys to produce bed-specific, digital, coal resource assessments for most of the top-producing coal beds and coal zones. Unlike past USGS assessments, this study will emphasize not only the quantity of coal but also the quality of the coal. Particular attention will be paid to the geochemical parameters that are thought to adversely effect combustion characteristics and possibly have adverse effects on the environment, including ash yield, sulfur, calorific value, and, the elements listed in the 1990 Clean Air Act Amendments. Geochemical databases produced for the assessed beds will be augmented by new, representative, coal analyses of major, minor, and trace elements. Products will include stratigraphic and geochemical data bases, original and remaining source calculations, and comprehensive digital maps at a scale of 1:250,000 or 1:500,000 of crop-line, coal thickness, coal structure, overburden thickness, mined-out areas, and geochemistry for each assessed coal beds.

  18. Investigation of Nucleation Bursts During the Pittsburgh Air Quality Study

    NASA Astrophysics Data System (ADS)

    Stanier, C. O.; Khlystov, A. Y.; Wittig, B.; Pandis, S. N.; Zhou, Y.; Bein, K.; Wexler, A. S.; Misra, C.; Sioutas, C.

    2002-12-01

    Homogeneous nucleation is one of the major sources of atmospheric particles on a global scale. Understanding nucleation is important for quantifying its role in shaping the ambient aerosol distribution and its effects on cloud properties and the planetary energy balance. Over 100 days with nucleation events were investigated during a sampling campaign sampling continental aerosols in Pittsburgh, Pennsylvania. Over 90,000 size distributions were collected over 12 months using Scanning Mobility Particle Sizers (SMPS) at three locations, including both urban and rural sites. Particle size distributions were measured down to 3 nm at the main site and to 10 nm at the other sites. The frequency of nucleation events was surprising. Approximately 50% of the study days were characterized by nucleation events. These events appear to occur over a large area and are not directly related to the emissions from the urban area. Some nucleation events occurred near simultaneously at samplers 500 km apart. Theories under investigation for the nucleation mechanism include sulfuric acid-water, sulfuric acid-water-ammonia, and secondary organic nucleation. The chemistry of the freshly nucleated and growing particles was investigated by collecting over 20,000 single particle mass spectra using Laser Ablation Aerosol Mass Spectrometry on particles as small as 20 nm. Results of TDMA and hygroscopic growth measurements of nuclei mode particles will also be presented. A large number of high-frequency gas, particle, and meteorological measurements were taken with collocated instruments. Data will be analyzed to elucidate possible cause-effect relationships and the dataset will be compared to theoretical estimates of nucleation rates for a number of mechanisms.

  19. Validation of the Pittsburgh Cardiac Arrest Category illness severity score

    PubMed Central

    Coppler, Patrick J.; Elmer, Jonathan; Calderon, Luis; Sabedra, Alexa; Doshi, Ankur A.; Callaway, Clifton W.; Rittenberger, Jon C.; Dezfulian, Cameron

    2015-01-01

    Background The purpose of this study was to validate the ability of an early post-cardiac arrest illness severity classification to predict patient outcomes. Methods The Pittsburgh Cardiac Arrest Category (PCAC) is a 4-level illness severity score that was found to be strongly predictive of outcomes in the initial derivation study. We assigned PCAC scores to consecutive in and out-of-hospital cardiac arrest subjects treated at two tertiary care centers between January 2011 and September 2013. We made assignments prospectively at Site 1 and retrospectively at Site 2. Our primary outcome was survival to hospital discharge. Inter-rater reliability of retrospective PCAC assessments was assessed. Secondary outcomes were favorable discharge disposition (home or acute rehabilitation), Cerebral Performance Category (CPC) and modified Rankin Scale (mRS) at hospital discharge. We tested the association of PCAC with each outcome using unadjusted and multivariable logistic regression. Results We included 607 cardiac arrest patients during the study (393 at Site 1 and 214 at Site 2). Site populations differed in age, arrest location, rhythm, use of hypothermia and distribution of PCAC. Inter-rater reliability of retrospective PCAC assignments was excellent (κ=0.81). PCAC was associated with survival (unadjusted odds ratio (OR) for Site 1: 0.33 (95% confidence interval (CI) 0.27–0.41)) Site 2: 0.32 (95%CI 0.24–0.43)) even after adjustment for other clinical variables (adjusted OR Site 1: 0.32 (95%CI 0.25–0.41)) Site 2: 0.31 (95%CI 0.22–0.44)). PCAC was predictive of secondary outcomes. Conclusions Our results confirm that PCAC is strongly predictive of survival and good functional outcome after cardiac arrest. PMID:25636896

  20. PaTH: towards a learning health system in the Mid-Atlantic region

    PubMed Central

    Amin, Waqas; Tsui, Fuchiang (Rich); Borromeo, Charles; Chuang, Cynthia H; Espino, Jeremy U; Ford, Daniel; Hwang, Wenke; Kapoor, Wishwa; Lehmann, Harold; Martich, G Daniel; Morton, Sally; Paranjape, Anuradha; Shirey, William; Sorensen, Aaron; Becich, Michael J; Hess, Rachel

    2014-01-01

    The PaTH (University of Pittsburgh/UPMC, Penn State College of Medicine, Temple University Hospital, and Johns Hopkins University) clinical data research network initiative is a collaborative effort among four academic health centers in the Mid-Atlantic region. PaTH will provide robust infrastructure to conduct research, explore clinical outcomes, link with biospecimens, and improve methods for sharing and analyzing data across our diverse populations. Our disease foci are idiopathic pulmonary fibrosis, atrial fibrillation, and obesity. The four network sites have extensive experience in using data from electronic health records and have devised robust methods for patient outreach and recruitment. The network will adopt best practices by using the open-source data-sharing tool, Informatics for Integrating Biology and the Bedside (i2b2), at each site to enhance data sharing using centrally defined common data elements, and will use the Shared Health Research Information Network (SHRINE) for distributed queries across the network. PMID:24821745

  1. PaTH: towards a learning health system in the Mid-Atlantic region.

    PubMed

    Amin, Waqas; Tsui, Fuchiang Rich; Borromeo, Charles; Chuang, Cynthia H; Espino, Jeremy U; Ford, Daniel; Hwang, Wenke; Kapoor, Wishwa; Lehmann, Harold; Martich, G Daniel; Morton, Sally; Paranjape, Anuradha; Shirey, William; Sorensen, Aaron; Becich, Michael J; Hess, Rachel

    2014-01-01

    The PaTH (University of Pittsburgh/UPMC, Penn State College of Medicine, Temple University Hospital, and Johns Hopkins University) clinical data research network initiative is a collaborative effort among four academic health centers in the Mid-Atlantic region. PaTH will provide robust infrastructure to conduct research, explore clinical outcomes, link with biospecimens, and improve methods for sharing and analyzing data across our diverse populations. Our disease foci are idiopathic pulmonary fibrosis, atrial fibrillation, and obesity. The four network sites have extensive experience in using data from electronic health records and have devised robust methods for patient outreach and recruitment. The network will adopt best practices by using the open-source data-sharing tool, Informatics for Integrating Biology and the Bedside (i2b2), at each site to enhance data sharing using centrally defined common data elements, and will use the Shared Health Research Information Network (SHRINE) for distributed queries across the network. PMID:24821745

  2. Particulate Air Pollution and the Rate of Hospitalization for Congestive Heart Failure among Medicare Beneficiaries in Pittsburgh, Pennsylvania.

    PubMed Central

    Wellenius, Gregory A.; Bateson, Thomas F.; Mittleman, Murray A.; Schwartz., Joel

    2006-01-01

    We used a case-crossover approach to evaluate the association between ambient air pollution and the rate of hospitalization for congestive heart failure (CHF) among Medicare recipients (age ≥ 65) residing in Allegheny County (Pittsburgh area), PA, during 1987–1999. We also explored effect modification by age, gender, and specific secondary diagnoses. During follow-up, there were 55,019 admissions with a primary diagnosis of CHF. We found that particulate matter with aerodynamic diameter ≤ 10 μm (PM10), carbon monoxide (CO), nitrogen dioxide (NO2), and sulfur dioxide – but not ozone – were positively and significantly associated with the rate of admission on the same day in single-pollutant models. The strongest associations were observed with CO, NO2 and PM10. The associations with CO and NO2 were the most robust in two-pollutant models, remaining statistically significant even after adjusting for other pollutants. Patients with a recent myocardial infarction were at greater risk of particulate-related admission, but there was otherwise no significant effect modification by age, gender, or other secondary diagnoses. These results suggest that short-term elevations in air pollution from traffic-related sources may trigger acute cardiac decompensation of heart failure patients and that those with certain comorbid conditions may be more susceptible to these effects. PMID:15901623

  3. The Greening of the David L. Lawrence Pittsburgh Convention Center

    NASA Astrophysics Data System (ADS)

    Leahy, Mark

    2009-03-01

    The David L. Lawrence Convention Center is the largest Gold LEED NC (new construction) certified convention center in the USA and the first of its kind in the world. The designation has been awarded by the United States Green Building Council through its Leadership in Energy and Environmental Design (LEED) Green Building Rating System. In this talk we discuss the unique green properties of this 1.5 million square foot Convention Center including the design and use of daylight, natural ventilation and other sustainable design and practices. No other building the size of the Convention Center (1.5 million square feet), uses natural ventilation or can illuminate an exhibition hall entirely through its windows and skylights. Approximately 75% of the convention center's exhibition space is lit by natural daylight. The use of natural ventilation and extensive day lighting is designed to reduce energy consumption by nearly 35% compared to traditional ventilated and lit buildings of a similar size.

  4. How Roebling did it: Building the world's first wire-rope suspension aqueduct in 1840s Pittsburgh

    NASA Astrophysics Data System (ADS)

    Gibbon, Donald L.

    2006-05-01

    The noted bridge designed John Roebling introduced his wire-rope suspension concept in Pittsburgh on a wooden aqueduct. His design was later implemented in bridges in Pittsburgh and elsewhere, including New York's Brooklyn Bridge. This article describes Roebling's work based on reviews of his notes and other historical documents.

  5. 78 FR 22843 - Foreign-Trade Zone 33-Pittsburgh, Pennsylvania, Authorization of Export Production Activity...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-17

    ... 400), including notice in the Federal Register inviting public comment (77 FR 77016, 12-31-2012). The... Production Activity, Tsudis Chocolate Company (Chocolate Confectionery Bars), Pittsburgh, Pennsylvania On December 4, 2012, Tsudis Chocolate Company, submitted a notification of proposed export production...

  6. Pittsburgh Public Schools' Excellence for All: Year 2 Evaluation. Documented Briefing. DB-575-PPS

    ERIC Educational Resources Information Center

    Tharp-Taylor, Shannah; Nelson, Catherine Awsumb; Hamilton, Laura S.; Yuan, Kun

    2009-01-01

    In 2007, the Pittsburgh Public Schools (PPS) requested that the RAND Corporation monitor implementation of year 2 (2007-2008) of the district's Excellence for All (EFA) initiative and provide feedback to district staff, the PPS board, and other stakeholders. In 2008, RAND expanded to a more comprehensive focus on effective implementation of EFA's…

  7. The Center on Race and Social Problems at the University of Pittsburgh

    ERIC Educational Resources Information Center

    Davis, Larry E.; Bangs, Ralph L.

    2007-01-01

    In 2002, the School of Social Work at the University of Pittsburgh established the Center on Race and Social Problems (CRSP). CRSP, which is the first race research center to be housed in a school of social work, has six foci: economic disparities; educational disparities; interracial group relations; mental health; youth, families, and elderly;…

  8. Communication-Based Training Programs and Evaluation Methods of Five Pittsburgh Hospitals.

    ERIC Educational Resources Information Center

    Corder, Lloyd E.

    A study to determine whether five Pittsburgh hospitals have communication training programs and whether the programs have been or are currently being evaluated examined the following research questions: (1) whether they have ever used a communication training program (i.e., writing, interpersonal communication, public speaking, group leadership);…

  9. Mental Health Services in the Pittsburgh Public Schools; 1967-1968.

    ERIC Educational Resources Information Center

    Richman, Vivien

    The 1967-68 mental health services (MHS) program in the Pittsburgh public school system, number of children served, studies undertaken, and other staff activities are considered. A research study of perceptual-motor dysfunction among emotionally disturbed, educable mentally handicapped, and normal children, and two perceptual surveys developed for…

  10. Japanese in the Elementary School: Description of an Innovative Pittsburgh Program.

    ERIC Educational Resources Information Center

    Antonek, Janis; And Others

    1994-01-01

    Describes an innovative Japanese elementary school foreign language (FLES) program introduced at the Laboratory School of the University of Pittsburgh. Lessons focused on thematic vocabulary presented within a context, a language function associated with the context, and some attention to the grammatical or syntactic structure necessary for…

  11. The Instructional Cabinet and Shared Decision Making in the Pittsburgh Public Schools: Theory, Practice and Evaluation.

    ERIC Educational Resources Information Center

    Wallace, Richard C., Jr.; And Others

    A significant body of research from business and industry has generally confirmed the contribution of participative decision-making to improved organizational effectiveness and employee morale. Following a literature review, this paper explores the implementation of shared decision-making in the Pittsburgh (Pennsylvania) Public Schools. The…

  12. Teacher Quality Roadmap: Improving Policies and Practices in Pittsburgh Public Schools

    ERIC Educational Resources Information Center

    Gonzalez, Angel; Kumar, Sudipti; Waymack, Nancy

    2014-01-01

    The Pittsburgh Public Schools study is the 12th district study since the National Council on Teacher Quality (NCTQ) began studying districts in-depth in 2009. The intent of these studies is to give select communities a comprehensive look at what is happening in their local school districts that may be either helping or hurting teacher quality, and…

  13. Pittsburgh Board of Public Education Task Force on Adolescent Pregnancy and Parenting: Minority Report.

    ERIC Educational Resources Information Center

    Kaleida, Phillip; And Others

    This minority report is a rebuttal to the recommendations made by the Task Force on Adolescent Pregnancy and Parenting of the Pittsburgh Board of Public Education. It takes issue with the way in which decisions were made and especially with the recommendation to establish school-based clinics (SBCs) in or near high risk schools. This minority…

  14. Boundary Spanning in Homeless Children's Education: Notes from an Emergent Faculty Role in Pittsburgh

    ERIC Educational Resources Information Center

    Miller, Peter M.

    2009-01-01

    Purpose: This From the Field article describes an emerging model of boundary spanning leadership in homeless education. Drawing from the pilot program that is being implemented in conjunction with the Homeless Children's Education Fund in Pittsburgh, the article identifies areas of promise and potential limits to university faculty involvement…

  15. Higher Education Sustainability in Pittsburgh: Highlights from the AASHE 2011 Campus Tours

    ERIC Educational Resources Information Center

    Srinivasamohan, Ashwini; Walton, Judy; Wagner, Margo

    2012-01-01

    This quote by ecologist, "Silent Spring" author and Chatham University alum Rachel Carson reminds us of the everyday tenacity needed in working to advance a sustainable and just world. This publication celebrates that tenacity in the higher education sector, specifically among institutions in the Pittsburgh area. Historically known for its steel…

  16. Improving Special Education Services in the Pittsburgh Public Schools, Winter 2009-10

    ERIC Educational Resources Information Center

    Council of the Great City Schools, 2010

    2010-01-01

    The Pittsburgh Public Schools (PPS) is the second-largest public school system in Pennsylvania. The state has only one other major big-city school system--Philadelphia's. The school district has made substantial gains in student achievement over the last several years, significantly increasing the numbers of students at the proficient level in…

  17. 77 FR 34297 - Approval and Promulgation of Air Quality Implementation Plans; Pennsylvania; Pittsburgh-Beaver...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-11

    ... FR 20664), that the Pittsburgh Area has attained the 1997 annual PM 2.5 NAAQS by its applicable... concentrations (62 FR 36852). At that time, EPA also established a 24- hour standard of 65 g/m\\3\\. See 40 CFR 50... PM 2.5 NAAQS based upon air quality monitoring data for calendar years 2001-2003 (70 FR 944)....

  18. The Effect of World War I on Black Occupational and Residential Segregation: The Case of Pittsburgh.

    ERIC Educational Resources Information Center

    Darden, Joe T.

    1988-01-01

    Study of census figures for Pittsburgh between 1900 and 1920 reveals that World War I had only a small measurable effect on reducing occupational segregation of Black men and White men and residential segregation by race. The war had no effect on reducing occupational segregation of Black women and White women. (BJV)

  19. THE LIBERTY ELEMENTARY SCHOOL, NEW LIFE FOR OLD SCHOOLS. PITTSBURGH DESIGN STUDY.

    ERIC Educational Resources Information Center

    Great Cities Research Council, Chicago, IL.

    A STUDY OF AN OLD SCHOOL BUILDING AND ITS NEIGHBORHOOD IS REPORTED, INCLUDING A DESCRIPTION OF EACH. A DESCRIPTION OF PITTSBURGH MASTER PLANS FOR ACHIEVING EDUCATIONAL EXCELLENCE AND RACIAL AND CULTURAL INTEGRATION INTRODUCES THE PAPER. URBAN DESIGN SOLUTIONS FOR THE NEIGHBORHOOD INCLUDE DISCUSSIONS OF NEW HOUSING, TRAFFIC CIRCULATION, PARKING…

  20. The Use of Research Libraries: A Comment about the Pittsburgh Study and Its Critics.

    ERIC Educational Resources Information Center

    Peat, W. Leslie

    1981-01-01

    Reviews the controversy surrounding the Pittsburgh study of library circulation and collection usage and proposes the use of citation analysis techniques as an acceptable method for measuring research use of a research library which will complement circulation studies. Five references are listed. (RAA)

  1. The Nonprofit Clinic at the University of Pittsburgh: Preparing Students for Transition to Professional Settings

    ERIC Educational Resources Information Center

    Kearns, Kevin P.

    2014-01-01

    The Nonprofit Clinic at the University of Pittsburgh gives graduate students the opportunity to serve as management consultants to nonprofit organizations. This article describes the learning objectives, logistics, and outcomes of the Nonprofit Clinic. Bloom's 1956 taxonomy of learning objectives is employed to assess learning outcomes.

  2. Processing the CONSOL Energy, Inc. Mine Maps and Records Collection at the University of Pittsburgh

    ERIC Educational Resources Information Center

    Rougeux, Debora A.

    2011-01-01

    This article describes the efforts of archivists and student assistants at the University of Pittsburgh's Archives Service Center to organize, describe, store, and provide timely and efficient access to over 8,000 maps of underground coal mines in southwestern Pennsylvania, as well the records that accompanied them, donated by CONSOL Energy, Inc.…

  3. Pittsburgh as a High Risk Population: The Potential Savings of a Personalized Dental Care Plan

    PubMed Central

    Ng, Andrew J.

    2016-01-01

    Objectives. Little evidence exists for the current standard of two annual preventative care visits. The purpose of this study was investigate this claim by modeling the potential savings of implementing a personalized care plan for high risk individuals in the Pittsburgh region. Methods. Using radiographs from 39 patients in the University of Pittsburgh Dental Registry and DNA Repository database, two models were created to analyse the direct savings of implementing a more aggressive preventative treatment plan and to view the longitudinal cost of increased annual yearly visits. Results. There is a significant decrease (p < 0.001) between original and modeled treatment cost when treatment severity is reduced. In addition, there is a significant decrease in adult lifetime treatment cost (p < 0.001) for up to four annual visits. Conclusions. Patients in high risk populations may see significant cost benefits in treatment cost when a personalized care plan, or higher annual preventative care visits, is implemented. PMID:27006657

  4. Pest status of the brown marmorated stink bug, Halyomorpha halys (Stal) in the USA

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Since its initial discovery in Allentown, PA, USA, the brown marmorated stink bug (BMSB), Halyomorpha halys (Heteroptera: Pentatomidae), has now officially been detected in 37 states and the District of Columbia in the USA. Isolated populations also exist in Switzerland and Canada. This Asian spec...

  5. Changing fuel use behavior: the Pittsburgh smoke control movement, 1940-1950

    SciTech Connect

    Tarr, J.A.

    1981-12-01

    Local policy development in Pittsburgh brought about cleaner air by influencing change in the household use of fuel and combustion equipment. By a combination of media campaigns, voluntary organizations, technical advisers, and business and labor leaders, the public was convinced of the necessity to reduce air pollution. The unique aspect is that the public accepted the costs of a long-range policy decision through education and persuasion. 20 refs.

  6. New Whole-House Solutions Case Study: Evaluating Through-Wall Air Transfer Fans, Pittsburgh, Pennsylvania

    SciTech Connect

    2014-10-01

    In this project, Building America team IBACOS performed field testing in a new construction unoccupied test house in Pittsburgh, Pennsylvania, to evaluate heating, ventilating, and air conditioning (HVAC) distribution systems during heating, cooling, and midseason conditions. The team evaluated a market-available through-wall air transfer fan system that provides air to the bedrooms.The relative ability of this system was considered with respect to relevant Air Conditioning Contractors of America and ASHRAE standards for house temperature uniformity and stability.

  7. Liver Procurement for Orthotopic Transplantation: An Analysis of the Pittsburgh Experience

    PubMed Central

    Van Thiel, David H.; Schade, Robert R.; Hakala, Thomas R.; Starzl, Thomas E.; Denny, Donald

    2010-01-01

    The incidence of prospective organ donors in the United States and the techniques which are to used to guarantee their optimal use after identification are analyzed. Attitudes of the public and health professionals toward organ donation are discussed. The organization of the Pittsburgh Organ Procurement Agency and its relationship to other such agencies is described. Finally, the presently used techniques of liver salvaging and preservation are outlined. PMID:6363261

  8. View of hammer nameplate (Chambersburg Engineering Company, Chambersburg, Penna USA) ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of hammer nameplate (Chambersburg Engineering Company, Chambersburg, Penna USA) and view north of Tony Talotta (heavy forger), Paul Azcharka (hammer operator), and Morty Hoffman (hammer operator helper) forging eyebolts. - Naval Base Philadelphia-Philadelphia Naval Shipyard, Structure Shop, League Island, Philadelphia, Philadelphia County, PA

  9. Air Quality from Early Pittsburgh to the Present: The Science of Change

    NASA Astrophysics Data System (ADS)

    Davidson, Cliff

    2009-03-01

    Throughout Pittsburgh's history over the past 250 years, coal reserves in the city and nearby have influenced its economy, demographics, and environmental quality. They have also played a major role in determining air quality in the region. For example, Pittsburgh became famous for its high particle loadings as early as the beginning of the nineteenth century, when the first complaints about air quality in the city were recorded. Nevertheless, residents tolerated the high coal smoke levels since jobs depended on the iron works, steel mills, and other industries. When natural gas was discovered just east of the city in the 1870's and replaced coal for some applications, particle concentrations decreased. But the local supplies of natural gas ran short several years later, and as industry continued to expand in the 1890's the city went back to the use of coal as its primary fuel. The return to smoky air was met with resistance that marked the beginning of sustained public outcry and initiation of several air pollution studies. The next half century was marked by periods of occasional high and low concentration, the latter due to events such as the financial panic of 1907 and the depression of the 1930's. It was not until the 1940's that effective regulations were passed to reduce smoky conditions. Particle levels fell throughout the 1950's and 1960's, and eventually the decline of heavy industry in Pittsburgh led to relatively clean air in many parts of the city. Over the past few decades, airborne particle concentrations averaged across the Pittsburgh region have remained below their earlier levels. However, there are still ``hot spots'' of high concentration resulting from regional background coming from upwind areas and emissions of some large sources that have continued to operate in the Pittsburgh region. Furthermore, the composition of airborne particles in the city has changed from earlier times. Such particles are now the result of emissions from sources in

  10. Phenotypes and Virulence among Staphylococcus aureus USA100, USA200, USA300, USA400, and USA600 Clonal Lineages

    PubMed Central

    King, Jessica M.; Kulhankova, Katarina; Stach, Christopher S.; Vu, Bao G.

    2016-01-01

    ABSTRACT Staphylococcus aureus diseases affect ~500,000 individuals per year in the United States. Worldwide, the USA100, USA200, USA400, and USA600 lineages cause many of the life-threatening S. aureus infections, such as bacteremia, infective endocarditis, pneumonia, toxic shock syndrome, and surgical site infections. However, the virulence mechanisms associated with these clonal lineages, in particular the USA100 and USA600 isolates, have been severely understudied. We investigated the virulence of these strains, in addition to strains in the USA200, USA300, and USA400 types, in well-established in vitro assays and in vivo in the rabbit model of infective endocarditis and sepsis. We show in the infective endocarditis and sepsis model that strains in the USA100 and USA600 lineages cause high lethality and are proficient in causing native valve infective endocarditis. Strains with high cytolytic activity or producing toxic shock syndrome toxin 1 (TSST-1) or staphylococcal enterotoxin C (SEC) caused lethal sepsis, even with low cytolytic activity. Strains in the USA100, USA200, USA400, and USA600 lineages consistently contained genes that encode for the enterotoxin gene cluster proteins, SEC, or TSST-1 and were proficient at causing infective endocarditis, while the USA300 strains lacked these toxins and were deficient in promoting vegetation growth. The USA100, USA200, and USA400 strains in our collection formed strong biofilms in vitro, whereas the USA200 and USA600 strains exhibited increased blood survival. Hence, infective endocarditis and lethal sepsis are multifactorial and not intrinsic to any one individual clonal group, further highlighting the importance of expanding our knowledge of S. aureus pathogenesis to clonal lineages causative of invasive disease. IMPORTANCE S. aureus is the leading cause of infective endocarditis in the developed world, affecting ~40,000 individuals each year in the United States, and the second leading cause of bacteremia (D

  11. Phenotypes and Virulence among Staphylococcus aureus USA100, USA200, USA300, USA400, and USA600 Clonal Lineages.

    PubMed

    King, Jessica M; Kulhankova, Katarina; Stach, Christopher S; Vu, Bao G; Salgado-Pabón, Wilmara

    2016-01-01

    Staphylococcus aureus diseases affect ~500,000 individuals per year in the United States. Worldwide, the USA100, USA200, USA400, and USA600 lineages cause many of the life-threatening S. aureus infections, such as bacteremia, infective endocarditis, pneumonia, toxic shock syndrome, and surgical site infections. However, the virulence mechanisms associated with these clonal lineages, in particular the USA100 and USA600 isolates, have been severely understudied. We investigated the virulence of these strains, in addition to strains in the USA200, USA300, and USA400 types, in well-established in vitro assays and in vivo in the rabbit model of infective endocarditis and sepsis. We show in the infective endocarditis and sepsis model that strains in the USA100 and USA600 lineages cause high lethality and are proficient in causing native valve infective endocarditis. Strains with high cytolytic activity or producing toxic shock syndrome toxin 1 (TSST-1) or staphylococcal enterotoxin C (SEC) caused lethal sepsis, even with low cytolytic activity. Strains in the USA100, USA200, USA400, and USA600 lineages consistently contained genes that encode for the enterotoxin gene cluster proteins, SEC, or TSST-1 and were proficient at causing infective endocarditis, while the USA300 strains lacked these toxins and were deficient in promoting vegetation growth. The USA100, USA200, and USA400 strains in our collection formed strong biofilms in vitro, whereas the USA200 and USA600 strains exhibited increased blood survival. Hence, infective endocarditis and lethal sepsis are multifactorial and not intrinsic to any one individual clonal group, further highlighting the importance of expanding our knowledge of S. aureus pathogenesis to clonal lineages causative of invasive disease. IMPORTANCE S. aureus is the leading cause of infective endocarditis in the developed world, affecting ~40,000 individuals each year in the United States, and the second leading cause of bacteremia (D. R

  12. Spatial variation in inversion-focused vs 24-h integrated samples of PM2.5 and black carbon across Pittsburgh, PA

    PubMed Central

    Tunno, Brett J; Michanowicz, Drew R; Shmool, Jessie L C; Kinnee, Ellen; Cambal, Leah; Tripathy, Sheila; Gillooly, Sara; Roper, Courtney; Chubb, Lauren; Clougherty, Jane E

    2016-01-01

    A growing literature explores intra-urban variation in pollution concentrations. Few studies, however, have examined spatial variation during “peak” hours of the day (e.g., rush hours, inversion conditions), which may have strong bearing for source identification and epidemiological analyses. We aimed to capture “peak” spatial variation across a region of complex terrain, legacy industry, and frequent atmospheric inversions. We hypothesized stronger spatial contrast in concentrations during hours prone to atmospheric inversions and heavy traffic, and designed a 2-year monitoring campaign to capture spatial variation in fine particles (PM2.5) and black carbon (BC). Inversion-focused integrated monitoring (0600–1100 hours) was performed during year 1 (2011–2012) and compared with 1-week 24-h integrated results from year 2 (2012–2013). To allocate sampling sites, we explored spatial distributions in key sources (i.e., traffic, industry) and potential modifiers (i.e., elevation) in geographic information systems (GIS), and allocated 37 sites for spatial and source variability across the metropolitan domain (~388 km2). Land use regression (LUR) models were developed and compared by pollutant, season, and sampling method. As expected, we found stronger spatial contrasts in PM2.5 and BC using inversion-focused sampling, suggesting greater differences in peak exposures across urban areas than is captured by most integrated saturation campaigns. Temporal variability, commercial and industrial land use, PM2.5 emissions, and elevation were significant predictors, but did not more strongly predict concentrations during peak hours. PMID:25921079

  13. Spatial variation in inversion-focused vs 24-h integrated samples of PM2.5 and black carbon across Pittsburgh, PA.

    PubMed

    Tunno, Brett J; Michanowicz, Drew R; Shmool, Jessie L C; Kinnee, Ellen; Cambal, Leah; Tripathy, Sheila; Gillooly, Sara; Roper, Courtney; Chubb, Lauren; Clougherty, Jane E

    2016-06-01

    A growing literature explores intra-urban variation in pollution concentrations. Few studies, however, have examined spatial variation during "peak" hours of the day (e.g., rush hours, inversion conditions), which may have strong bearing for source identification and epidemiological analyses. We aimed to capture "peak" spatial variation across a region of complex terrain, legacy industry, and frequent atmospheric inversions. We hypothesized stronger spatial contrast in concentrations during hours prone to atmospheric inversions and heavy traffic, and designed a 2-year monitoring campaign to capture spatial variation in fine particles (PM2.5) and black carbon (BC). Inversion-focused integrated monitoring (0600-1100 hours) was performed during year 1 (2011-2012) and compared with 1-week 24-h integrated results from year 2 (2012-2013). To allocate sampling sites, we explored spatial distributions in key sources (i.e., traffic, industry) and potential modifiers (i.e., elevation) in geographic information systems (GIS), and allocated 37 sites for spatial and source variability across the metropolitan domain (~388 km(2)). Land use regression (LUR) models were developed and compared by pollutant, season, and sampling method. As expected, we found stronger spatial contrasts in PM2.5 and BC using inversion-focused sampling, suggesting greater differences in peak exposures across urban areas than is captured by most integrated saturation campaigns. Temporal variability, commercial and industrial land use, PM2.5 emissions, and elevation were significant predictors, but did not more strongly predict concentrations during peak hours. PMID:25921079

  14. Creating New Meanings in Leading Learning. Proceedings [of the] National Conference on Alternative and External Degree Programs for Adults (22nd, Pittsburgh, PA, October 9-12, 2002).

    ERIC Educational Resources Information Center

    American Council on Education, Washington, DC.

    These proceedings are comprised of 25 presentations divided into 5 "tracks." Section I, Diversity and Social Justice, has "Free to Learn with Body and Soul Jazz Divas, Beat Poets, and Street Preachers" (Ferrante, Belcastro); "Clashing Cultures in Our Classrooms" (Gabrich, Rothenberger); "Encouraging Adults in College to Engage with Inclusive…

  15. Bridges to the Future: Building Linkages for Institutional Research. North East Association for Institutional Research Annual Conference Proceedings (27th, Pittsburgh, PA, November 4-7, 2000).

    ERIC Educational Resources Information Center

    North East Association for Institutional Research.

    This document contains papers, summaries of panel presentations, and work share meetings from the annual conference of the North East Association for Institutional Research. The papers are: (1) "The Influence of Personality Traits, Pre-College Characteristics, and Co-Curricular Experiences on College Outcomes" (Karen W. Bauer); (2) "Threading the…

  16. ETV STATEMENT - PHYSICAL REMOVAL OF CRYPTOSPORIDIUM OOCYSTS AND GIARDIA CYSTS IN DRINKING WATER - ZENON ZEEWEED ZW500 ULTRAFILTRATION MEMBRANE SYSTEM AT PITTSBURGH, PA

    EPA Science Inventory

    Verification testing of the ZENON Environmental Inc. ZeeWeed ZW500 UF Drinking Water System was conducted from 2/6-3/7/99. The treatment system underwent Giardia and Cryptosporidium removal challenge testing on 3/2/99 and demonstrated a 5.3 log10 removal of Giardia cysts and a 6...

  17. Developments in experimental techniques in heat transfer and combustion; Proceedings of the Twenty-fourth National Heat Transfer Conference and Exhibition, Pittsburgh, PA, Aug. 9-12, 1987

    NASA Astrophysics Data System (ADS)

    Warrington, R. O., Jr.; Chen, M. M.; Felske, J. D.; Grosshandler, W. L.

    1987-08-01

    This volume includes articles related to the developments in experimental techniques in heat transfer and in combustion. Papers are presented on high-resolution heat-transfer-coefficient maps applicable to compound-curve surfaces using liquid crystals in a transient wind tunnel, an instrument for the measurement of the heat flux distribution along a contour of a surface at uniform temperature, an advanced viscometric thermometer for steady and unsteady states temperature measurement in electric or magnetic fields, the development of a thermopile-based deposition sensor, and the measurement of surface heat flux, using the Peltier effect. Consideration is also given to a new method of experimentally determining heat transfer coefficients in direct-contact bubble evaporation, temperature measurements by light scattering methods, the design calibration and error analysis of instrumentation for heat transfer in internal combustion, the application of an electrodynamic balance to study mass transfer from a single particle, single droplet studies in a hot high-pressure environment, and the measurement of flame propagation through a moving mixture.

  18. Reclaim Northside: An Environmental Justice Approach to Address Vacant Land in Pittsburgh.

    PubMed

    Teixeira, Samantha; Sing, Evaine

    2016-01-01

    Urban decline, disinvestment, and blight have not traditionally been addressed by the environmental conservation movement. In this article, we describe an environmental justice-focused intervention located in Pittsburgh, Pennsylvania, that aimed to increase community empowerment to address urban environmental injustices by training residents to reclaim vacant land. We use a case study approach to illustrate resident perceptions of the impact of vacant land and urban decay. The results suggest that these residents viewed vacancy as an important indicator of community well-being and social inequality. We use a social and environmental justice framework to describe results and implications for practitioners and researchers. PMID:27214676

  19. Building America Case Study: Evaluating Through-Wall Air Transfer Fans, Pittsburgh, Pennsylvania (Fact Sheet)

    SciTech Connect

    Not Available

    2014-10-01

    In this project, Building America team IBACOS performed field testing in a new construction unoccupied test house in Pittsburgh, Pennsylvania to evaluate heating, ventilating, and air conditioning (HVAC) distribution systems during heating, cooling, and midseason conditions. Four air-based HVAC distribution systems were assessed:-a typical airflow ducted system to the bedrooms, a low airflow ducted system to the bedrooms, a system with transfer fans to the bedrooms, and a system with no ductwork to the bedrooms. The relative ability of each system was considered with respect to relevant Air Conditioning Contractors of America and ASHRAE standards for house temperature uniformity and stability, respectively.

  20. Elements related to attrition of women faculty at the University of Pittsburgh, School of Medicine: A case study

    NASA Astrophysics Data System (ADS)

    Gandhi, Pooja

    Recent studies have shown that the number of women faculty in academic medicine is much lesser than the number of women that are graduating from medical schools. Many academic institutes face the challenge of retaining talented faculty and this attrition from academic medicine prevents career advancement of women faculty. This case study attempts to identify some of the reasons for dissatisfaction that may be related to the attrition of women medical faculty at the University of Pittsburgh, School of Medicine. Data was collected using a job satisfaction survey, which consisted of various constructs that are part of a faculty's job and proxy measures to gather the faculty's intent to leave their current position at the University of Pittsburgh or academic medicine in general. The survey results showed that although women faculty were satisfied with their job at the University of Pittsburgh, there are some important factors that influenced their decision of potentially dropping out. The main reasons cited by the women faculty were related to funding pressures, work-life balance, mentoring of junior faculty and the amount of time spent on clinical responsibilities. The analysis of proxy measures showed that if women faculty decided to leave University of Pittsburgh, it would most probably be due to better opportunity elsewhere followed by pressure to get funding. The results of this study aim to provide the School of Medicine at the University of Pittsburgh with information related to attrition of its women faculty and provide suggestions for implications for policy to retain their women faculty.

  1. 76 FR 25704 - Announcement of Funding Awards for the Emergency Capital Repair Grant Program; Fiscal Year 2010

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-05

    ..., Inc... Morgantown......... WV 49 351,114 Repair the elevators and replace the windows, cooling chassis... Angeles. HVAC units. Steelworkers Tower NCSC/USA Housing Pittsburgh......... PA 80 406,967 Replace...

  2. The contribution of secondary organic aerosol to PM2.5 concentrations in Pittsburgh

    NASA Astrophysics Data System (ADS)

    Cabada, J. C.; Pandis, S. N.; Robinson, A. L.; Subramanian, R.; Polidori, A.; Turpin, B.

    2002-12-01

    A major component of PM2.5 in the Eastern US is carbonaceous material. This organic particulate matter results from both direct emissions from sources such as automobiles, trucks and industries (primary), and from the oxidation of organic gases (secondary). Data from the Pittsburgh Air Quality Study are used to examine the contribution of secondary organic aerosol to the total organic aerosol loading measured in the city during 2001 and 2002. The contribution of secondary organic aerosol is estimated by using elemental carbon as a tracer for primary emissions of organic particulate matter (OC to EC ratio approach). A systematic method for the determination of the primary ratio has been developed based on the correlation of measurements of OC and EC to gaseous tracers of photochemical activity (O3) and primary emissions (CO, NOx). This method is applied to different sets of organic aerosols measurements (using an undenuded sampler, a denuded sampler and an in-situ carbon analyzer) for carbonaceous concentrations. Consistent results for the SOA fraction are obtained when the method is applied to the different sets of measurements for OC and EC. This approach indicates that between 20 and 40% of the organic particulate matter in Pittsburgh during the summer and fall of 2001 is secondary in origin while negligible contributions of SOA are estimated for the winter of 2001 and the spring of 2002.

  3. Validation of the French version of the Pittsburgh Sleep Quality Index Addendum for posttraumatic stress disorder

    PubMed Central

    Ait-Aoudia, Malik; Levy, Pierre P.; Bui, Eric; Insana, Salvatore; de Fouchier, Capucine; Germain, Anne; Jehel, Louis

    2013-01-01

    Background Sleep disturbances are one of the main complaints of patients with trauma-related disorders. The original Pittsburgh Sleep Quality Index Addendum for PTSD (PSQI-A) is self-report instrument developed to evaluate posttraumatic stress disorder (PTSD)-specific sleep disturbances in trauma-exposed individuals. However, to date, the PSQI-A has not yet been translated nor validated in French. Objective The present study aims to: a) translate the PSQI-A into French, and b) examine its psychometric properties. Method Seventy-three adult patients (mean age=40.3 [SD=15.0], 75% females) evaluated in a specialized psychotraumatology unit completed the French versions of the PSQI-A, Pittsburgh Sleep Quality Index (PSQI), Hospital Anxiety and Depression Scale (HADS), and Impact Event Scale-Revised (IES-R). Results The French version of the PSQI-A showed satisfactory internal consistency, inter-item correlations, item correlations with the total score, convergent validity with PTSD and anxiety measures, and divergent validity with a depression measure. Conclusion Our findings support the use of the French version of the PSQI-A for both clinical care and research. The French version of the PSQI-A is an important addition to the currently available instruments that can be used to examine trauma-related sleep disturbances among French-speaking individuals. PMID:24044071

  4. Cluster CAA Module for PaPCo

    NASA Astrophysics Data System (ADS)

    Faden, J.; Åsnes, A.; Friedel, R.; Taylor, M.; McCaffrey, S.; Perry, C.; Goldstein, M. L.

    A PaPCo module for visualization of data from the CAA has been developed. This module retrieves data from the CAA web interface, and allows for discovery and plotting of new datasets. PaPCo is modular, open source IDL software that uses plug-in modules to bring new datasets on to a stack of time series plots (www.papco.org). PaPCo includes modules for plotting data from Cluster/PEACE and Cluster/RAPID, CDA Web data which includes Cluster Prime Parameters, and various modules from CRRES, POLAR, GPS, and many other spacecraft. The Cluster CAA module is presented, as well as a brief description of PaPCo's use and installation procedure.

  5. 78 FR 47814 - Pennsylvania Disaster # PA-00059

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-06

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster PA-00059 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY.... Small Business Administration, Processing And Disbursement Center, 14925 Kingsport Road, Fort Worth,...

  6. Oxidation of gas-phase protactinium ions, Pa+ and Pa2+: formation and properties of PaO2(2+)(g), protactinyl.

    PubMed

    Santos, Marta; de Matos, António Pires; Marçalo, Joaquim; Gibson, John K; Haire, Richard G; Tyagi, Rajni; Pitzer, Russell M

    2006-05-01

    Oxidation reactions of bare and ligated, monopositive, and dipositive Pa ions in the gas phase were studied by Fourier transform ion cyclotron resonance mass spectrometry. Seven oxidants were employed, ranging from the thermodynamically robust N(2)O to the relatively weak CH(2)O-all oxidized Pa(+) to PaO(+) and PaO(+) to PaO(2)(+). On the basis of experimental observations, it was established that D[Pa(+)-O] and D[OPa(+)-O] > or = 751 kJ mol(-1). Estimates for D[Pa(+)-O], D[OPa(+)-O], IE[PaO], and IE[PaO(2)] were also obtained. The seven oxidants reacted with Pa(2+) to produce PaO(2+), indicating that D[Pa(2+)-O] > or = 751 kJ mol(-1). A particularly notable finding was the oxidation of PaO(2+) by N(2)O to PaO(2)(2+), a species, which formally comprises Pa(VI). Collision-induced dissociation of PaO(2)(2+) suggested the protactinyl connectivity, {O-Pa-O}(2+). The experimentally determined IE[PaO(2)(+)] approximately 16.6 eV is in agreement with self-consistent-field and configuration interaction calculations for PaO(2)(+) and PaO(2)(2+). These calculations provide insights into the electronic structures of these ions and indicate the participation of 5f orbitals in bonding and a partial "6p hole" in the case of protactinyl. It was found that PaO(2)(2+) catalyzes the oxidation of CO by N(2)O-such O atom transport via a dipositive metal oxide ion is distinctive. It was also observed that PaO(2)(2+) is capable of activating H(2) to form the stable PaO(2)H(2+) ion. PMID:16640369

  7. Using a Merit-Based Scholarship Program to Increase Rates of College Enrollment in an Urban School District: The Case of the Pittsburgh Promise

    ERIC Educational Resources Information Center

    Bozick, Robert; Gonzalez, Gabriella; Engberg, John

    2015-01-01

    The Pittsburgh Promise is a scholarship program that provides $5,000 per year toward college tuition for public high school graduates in Pittsburgh, Pennsylvania who earned a 2.5 GPA and a 90% attendance record. This study used a difference-in-difference design to assess whether the introduction of the Promise scholarship program directly…

  8. Partners in Pittsburgh Public Schools' Excellence for All Initiative: Findings from the First Year of Implementation. Documented Briefing. DB-544-FFE

    ERIC Educational Resources Information Center

    Tharp-Taylor, Shannah; Nelson, Catherine Awsumb; Dembosky, Jacob W.; Gill, Brian

    2007-01-01

    The Pittsburgh Public School District asked the RAND Corporation to monitor the first year's implementation (2006-2007) of Excellence for All (EFA) and provide feedback to district staff, the board, and other stakeholders. The Pittsburgh Public School District leadership developed EFA with the aim of increasing student achievement by improving…

  9. Functional Characterization of Phalaenopsis aphrodite Flowering Genes PaFT1 and PaFD

    PubMed Central

    Jang, Seonghoe; Choi, Sang-Chul; Li, Hsing-Yi; An, Gynheung; Schmelzer, Elmon

    2015-01-01

    We show that the key flowering regulators encoded by Phalaenopsis aphrodite FLOWERING LOCUS T1 (PaFT1) and PaFD share high sequence homologies to these from long-day flowering Arabidopsis and short-day flowering rice. Interestingly, PaFT1 is specifically up-regulated during flowering inductive cooling treatment but is not subjected to control by photoperiod in P. aphrodite. Phloem or shoot apex-specific expression of PaFT1 restores the late flowering of Arabidopsis ft mutants. Moreover, PaFT1 can suppress the delayed flowering caused by SHORT VEGATATIVE PHASE (SVP) overexpression as well as an active FRIGIDA (FRI) allele, indicating the functional conservation of flowering regulatory circuit in different plant species. PaFT1 promoter:GUS in Arabidopsis showed similar staining pattern to that of Arabidopsis FT in the leaves and guard cells but different in the shoot apex. A genomic clone or heat shock-inducible expression of PaFT1 is sufficient to the partial complementation of the ft mutants. Remarkably, ectopic PaFT1 expression also triggers precocious heading in rice. To further demonstrate the functional conservation of the flowering regulators, we show that PaFD, a bZIP transcription factor involved in flowering promotion, interacts with PaFT1, and PaFD partially complemented Arabidopsis fd mutants. Transgenic rice expressing PaFD also flowered early with increased expression of rice homologues of APETALA1 (AP1). Consistently, PaFT1 knock-down Phalaenopsis plants generated by virus-induced gene silencing exhibit delayed spiking. These studies suggest functional conservation of FT and FD genes, which may have evolved and integrated into distinct regulatory circuits in monopodial orchids, Arabidopsis and rice that promote flowering under their own inductive conditions. PMID:26317412

  10. 231Pa and 233Pa Neutron-Induced Fission Data Analysis

    SciTech Connect

    Maslov, V.M.; Tetereva, N.A.; Baba, M.; Hasegawa, A.; Kornilov, N.V.; Kagalenko, A.B.

    2005-05-24

    The 231Pa and 233Pa neutron-induced fission cross-section database is analyzed within the Hauser-Feshbach approach. The consistency of neutron-induced fission cross-section data and data extracted from transfer reactions is investigated. The fission probabilities of Pa, fissioning in 231,233Pa(n,nf) reactions, are defined by fitting (3He,d) or (3He,t) transfer-reaction data. The present estimate of the 233Pa(n,f) fission cross section above the emissive fission threshold is supported by smooth level-density parameter systematics, validated in the case of the 231Pa(n,f) data description up to En =20 MeV.

  11. Report on the Study of Library Use at Pitt by Professor Allen Kent, et al. (A Pittsburgh Reply).

    ERIC Educational Resources Information Center

    MacLeod, Murdo J.; Barkowski, Casimir

    This report from the Senate Library Committee at the University of Pittsburgh evaluates a widely publicized study of monograph and periodical use conducted at Pitt by Professor Allen Kent and his associates from 1975-1977. Areas of the study which are examined include structure in text and footnotes, and experimental design, execution, and…

  12. The Use of Information Theory to Study Human Learning. Project on the Information Memory Model, University of Pittsburgh.

    ERIC Educational Resources Information Center

    Moser, Gene W.

    As the proceedings of a symposium held at the 1973 Annual Meeting of the National Association for Research in Science Teaching, theoretical and experimental results from research in the use of information theory to study human learning are presented in this volume to reflect the efforts made at the University of Pittsburgh over the past four…

  13. Principals at the Center: The Pittsburgh School District Believes Cultivating Effective Instructional Leaders is the Key to School Improvement

    ERIC Educational Resources Information Center

    Samuels, Christina A.

    2008-01-01

    For schools to improve in the Pittsburgh school district, it is not just the children who have to learn. Embracing the idea that strong principals are essential to academic success, top administrators have launched several initiatives based on the philosophy that school leaders need to be cultivated as carefully as students. A committee of…

  14. Findings From the Pittsburgh Youth Study: Cognitive Impulsivity and Intelligence as Predictors of the Age-Crime Curve

    ERIC Educational Resources Information Center

    Loeber, Rolf; Menting, Barbara; Lynam, Donald R.; Moffitt, Terri E.; Stouthamer-Loeber, Magda; Stallings, Rebecca; Farrington, David P.; Pardini, Dustin

    2012-01-01

    Objective: This article first summarizes key research findings from the Pittsburgh Youth Study from 1987 to the present, and focuses on delinquency in 1,517 young men who have been followed up from late childhood into their 20s. Second, the article addresses how indicators of self-control prospectively predict later offending, and whether the…

  15. An Analysis of Two Beginning Reading Programs: Scott Foresman's "Reading Unlimited" and Pittsburgh LRDC's "New Primary Grades Reading Systems."

    ERIC Educational Resources Information Center

    Popp, Helen Mitchell

    The two reading programs discussed in this paper, "Reading Unlimited" (RU) published by Scott Foresman and "New Primary Grades Reading Systems" (RS) by the University of Pittsburgh Learning Research and Development Center, provide maximal contrasts in materials and teaching strategies. The instructional strategies in RU are analytic and inductive,…

  16. Creating Social Connections in Higher Education: Insights from the Campus Canines Program at the University of Pittsburgh

    ERIC Educational Resources Information Center

    Camaioni, Nicole

    2013-01-01

    The overall purpose of this study was to capture the relationships made during the Campus Canines Program, an animal-assisted activity program, at the University of Pittsburgh. Meaningful social relationships create greater educational satisfaction. These social relationships are an important piece to creating and sustaining student involvement,…

  17. 1997 environmental monitoring report for the Bettis Atomic Power Laboratory, Pittsburgh Site

    SciTech Connect

    1997-12-31

    The 1997 results for the Bettis-Pittsburgh radiological and nonradiological environmental monitoring programs are presented. The results demonstrate that the existing procedures ensured that releases to the environment during 1997 were in accordance with applicable Federal, State, County, and local regulations. Evaluation of the environmental data indicates tat current operations at the Site continue to have no adverse effect on human health and the quality of the environment. A conservative assessment of radiation exposure to the general public as a result of Site operations demonstrates that the dose received by any member of the public was well below the most restrictive dose limits established by the Environmental Protection Agency, the Nuclear Regulatory Commission, and the US Department of Energy. A risk assessment of potentially exposed populations to chemical residues in the environment at the Site demonstrates that these residues do not pose any significant risk to human health or the environment.

  18. 1999 environmental monitoring report for the Bettis Atomic Power Laboratory, Pittsburgh Site

    SciTech Connect

    2000-12-01

    The 1999 results for the Bettis-Pittsburgh radiological and nonradiological environmental monitoring programs are presented. The results demonstrate that the existing procedures ensured that releases to the environment during 1999 were in accordance with applicable Federal, State, County, and local regulations. Evaluation of the environmental data indicates that current operations at the Site continue to have no adverse effect on human health and the quality of the environment. A conservative assessment of radiation exposure to the general public as a result of Site operations demonstrates that the dose received by any member of the public was well below the most restrictive dose limits established by the Environmental Protection Agency, the Nuclear Regulatory Commission, and the US Department of Energy. A risk assessment of potentially exposed populations to chemical residues in the environment at the Site demonstrates that these residues do not pose any significant risk to human health or the environment.

  19. 2003 Environmental Monitoring Report for the Bettis Atomic Power Laboratory Pittsburgh Site

    SciTech Connect

    2003-12-31

    The 2003 results for the Bettis-Pittsburgh radiological and nonradiological environmental monitoring programs are presented. The results demonstrate that the existing procedures ensured that releases to the environment during 2003 were in accordance with applicable Federal, State, County, and local regulations. Evaluation of the environmental data indicates that current operations at the Site continue to have no adverse effect on human health and the quality of the environment. A conservative assessment of radiation exposure to the general public as a result of Site operations demonstrates that the dose received by any member of the public was well below the most restrictive dose limits established by the Environmental Protection Agency, the Nuclear Regulatory Commission, and the U.S. Department of Energy. A risk assessment of potentially exposed populations to chemical residues in the environment at the Site demonstrates that any potential risk posed by these residues in much less than the risks encountered in normal everyday life.

  20. Structural Validity of the Pittsburgh Sleep Quality Index in Chinese Undergraduate Students.

    PubMed

    Guo, Suran; Sun, Wenmei; Liu, Chang; Wu, Siwei

    2016-01-01

    The purpose of this study was to examine the structural validity of the Pittsburgh Sleep Quality Index (PSQI) in Chinese undergraduate students. A cross-sectional questionnaire survey with 631 Chinese undergraduate students was conducted, and the questionnaire package included a measure of demographic characteristics, PSQI, Chinese editions of Center for Epidemiologic Studies-Depression, State- Trait Anxiety Inventory, Rumination Response Scale, and Perceived Social Support Scale. Results showed that the item "use of sleep medicine" was not suitable for use with this population, that a two-factor model provided the best fit to the data as assessed through confirmatory factor analysis, and that other indices were consistently correlated with the sleep quality but not the sleep efficiency factor. PMID:27551270

  1. Structural Validity of the Pittsburgh Sleep Quality Index in Chinese Undergraduate Students

    PubMed Central

    Guo, Suran; Sun, Wenmei; Liu, Chang; Wu, Siwei

    2016-01-01

    The purpose of this study was to examine the structural validity of the Pittsburgh Sleep Quality Index (PSQI) in Chinese undergraduate students. A cross-sectional questionnaire survey with 631 Chinese undergraduate students was conducted, and the questionnaire package included a measure of demographic characteristics, PSQI, Chinese editions of Center for Epidemiologic Studies-Depression, State- Trait Anxiety Inventory, Rumination Response Scale, and Perceived Social Support Scale. Results showed that the item “use of sleep medicine” was not suitable for use with this population, that a two-factor model provided the best fit to the data as assessed through confirmatory factor analysis, and that other indices were consistently correlated with the sleep quality but not the sleep efficiency factor. PMID:27551270

  2. Pittsburgh compound B imaging and cerebrospinal fluid amyloid-β in a multicentre European memory clinic study

    PubMed Central

    Leuzy, Antoine; Chiotis, Konstantinos; Hasselbalch, Steen G.; Rinne, Juha O.; de Mendonça, Alexandre; Otto, Markus; Lleó, Alberto; Castelo-Branco, Miguel; Santana, Isabel; Johansson, Jarkko; Anderl-Straub, Sarah; von Arnim, Christine A. F.; Beer, Ambros; Blesa, Rafael; Fortea, Juan; Herukka, Sanna-Kaisa; Portelius, Erik; Pannee, Josef; Zetterberg, Henrik; Blennow, Kaj

    2016-01-01

    The aim of this study was to assess the agreement between data on cerebral amyloidosis, derived using Pittsburgh compound B positron emission tomography and (i) multi-laboratory INNOTEST enzyme linked immunosorbent assay derived cerebrospinal fluid concentrations of amyloid-β42; (ii) centrally measured cerebrospinal fluid amyloid-β42 using a Meso Scale Discovery enzyme linked immunosorbent assay; and (iii) cerebrospinal fluid amyloid-β42 centrally measured using an antibody-independent mass spectrometry-based reference method. Moreover, we examined the hypothesis that discordance between amyloid biomarker measurements may be due to interindividual differences in total amyloid-β production, by using the ratio of amyloid-β42 to amyloid-β40. Our study population consisted of 243 subjects from seven centres belonging to the Biomarkers for Alzheimer’s and Parkinson’s Disease Initiative, and included subjects with normal cognition and patients with mild cognitive impairment, Alzheimer’s disease dementia, frontotemporal dementia, and vascular dementia. All had Pittsburgh compound B positron emission tomography data, cerebrospinal fluid INNOTEST amyloid-β42 values, and cerebrospinal fluid samples available for reanalysis. Cerebrospinal fluid samples were reanalysed (amyloid-β42 and amyloid-β40) using Meso Scale Discovery electrochemiluminescence enzyme linked immunosorbent assay technology, and a novel, antibody-independent, mass spectrometry reference method. Pittsburgh compound B standardized uptake value ratio results were scaled using the Centiloid method. Concordance between Meso Scale Discovery/mass spectrometry reference measurement procedure findings and Pittsburgh compound B was high in subjects with mild cognitive impairment and Alzheimer’s disease, while more variable results were observed for cognitively normal and non-Alzheimer’s disease groups. Agreement between Pittsburgh compound B classification and Meso Scale Discovery/mass spectrometry

  3. Pittsburgh compound B imaging and cerebrospinal fluid amyloid-β in a multicentre European memory clinic study.

    PubMed

    Leuzy, Antoine; Chiotis, Konstantinos; Hasselbalch, Steen G; Rinne, Juha O; de Mendonça, Alexandre; Otto, Markus; Lleó, Alberto; Castelo-Branco, Miguel; Santana, Isabel; Johansson, Jarkko; Anderl-Straub, Sarah; von Arnim, Christine A F; Beer, Ambros; Blesa, Rafael; Fortea, Juan; Herukka, Sanna-Kaisa; Portelius, Erik; Pannee, Josef; Zetterberg, Henrik; Blennow, Kaj; Nordberg, Agneta

    2016-09-01

    The aim of this study was to assess the agreement between data on cerebral amyloidosis, derived using Pittsburgh compound B positron emission tomography and (i) multi-laboratory INNOTEST enzyme linked immunosorbent assay derived cerebrospinal fluid concentrations of amyloid-β42; (ii) centrally measured cerebrospinal fluid amyloid-β42 using a Meso Scale Discovery enzyme linked immunosorbent assay; and (iii) cerebrospinal fluid amyloid-β42 centrally measured using an antibody-independent mass spectrometry-based reference method. Moreover, we examined the hypothesis that discordance between amyloid biomarker measurements may be due to interindividual differences in total amyloid-β production, by using the ratio of amyloid-β42 to amyloid-β40 Our study population consisted of 243 subjects from seven centres belonging to the Biomarkers for Alzheimer's and Parkinson's Disease Initiative, and included subjects with normal cognition and patients with mild cognitive impairment, Alzheimer's disease dementia, frontotemporal dementia, and vascular dementia. All had Pittsburgh compound B positron emission tomography data, cerebrospinal fluid INNOTEST amyloid-β42 values, and cerebrospinal fluid samples available for reanalysis. Cerebrospinal fluid samples were reanalysed (amyloid-β42 and amyloid-β40) using Meso Scale Discovery electrochemiluminescence enzyme linked immunosorbent assay technology, and a novel, antibody-independent, mass spectrometry reference method. Pittsburgh compound B standardized uptake value ratio results were scaled using the Centiloid method. Concordance between Meso Scale Discovery/mass spectrometry reference measurement procedure findings and Pittsburgh compound B was high in subjects with mild cognitive impairment and Alzheimer's disease, while more variable results were observed for cognitively normal and non-Alzheimer's disease groups. Agreement between Pittsburgh compound B classification and Meso Scale Discovery/mass spectrometry reference

  4. Psychometric Properties of the Pittsburgh Sleep Quality Index (PSQI) in a Cohort of Peruvian Pregnant Women

    PubMed Central

    Zhong, Qiu-Yue; Gelaye, Bizu; Sánchez, Sixto E.; Williams, Michelle A.

    2015-01-01

    Study Objectives: We sought to evaluate the construct validity and factor structure of the Spanish-language version of the Pittsburgh Sleep Quality Index (PSQI) among pregnant Peruvian women. Methods: A cohort of 642 women were interviewed at ≤ 16 weeks of gestation. During interview, we ascertained information about lifestyles, demographics, sleep characteristics, and mood symptoms. Stress induced sleep disturbance, depressive symptoms, and anxiety symptoms were evaluated using the Ford Insomnia Response to Stress Test (FIRST), Patient Health Questionnaire-9 (PHQ-9), and Generalized Anxiety Disorder-7 (GAD-7) assessment scales, respectively. Consistency indices, exploratory and confirmatory factor analyses, correlations, and logistic regressions were used. Results: Both exploratory and confirmatory factor analyses indicated a three-factor solution: sleep quality, sleep efficiency, and sleep medication. We observed significantly positive correlations of the PSQI with the FIRST (0.42), the PHQ-9 (0.49), and the GAD-7 (0.46). Poor sleepers (PSQI global score > 5) had significantly increased odds of experiencing stress-induced sleep disturbance (odds ratio, OR = 3.57; 95% CI: 2.40, 5.31), depression (OR = 5.48; 95% CI: 3.58, 8.37), and generalized anxiety disorder (OR = 4.57; 95% CI: 3.08, 6.76). Conclusions: The Spanish-language version of the PSQI instrument was found to have good construct validity among pregnant Peruvian women. Consistent with some other studies, the PSQI was found to have a three-factor structure. Further assessment and validation studies are needed to determine whether the three, factor-specific scoring of the PSQI is favored over the PSQI global score in diverse populations. Citation: Zhong QY, Gelaye B, Sánchez SE, Williams MA. Psychometric properties of the Pittsburgh Sleep Quality Index (PSQI) in a cohort of Peruvian pregnant women. J Clin Sleep Med 2015;11(8):869–877. PMID:25845902

  5. A geostatistical approach to predicting sulfur content in the Pittsburgh coal bed

    USGS Publications Warehouse

    Watson, W.D.; Ruppert, L.F.; Bragg, L.J.; Tewalt, S.J.

    2001-01-01

    The US Geological Survey (USGS) is completing a national assessment of coal resources in the five top coal-producing regions in the US. Point-located data provide measurements on coal thickness and sulfur content. The sample data and their geologic interpretation represent the most regionally complete and up-to-date assessment of what is known about top-producing US coal beds. The sample data are analyzed using a combination of geologic and Geographic Information System (GIS) models to estimate tonnages and qualities of the coal beds. Traditionally, GIS practitioners use contouring to represent geographical patterns of "similar" data values. The tonnage and grade of coal resources are then assessed by using the contour lines as references for interpolation. An assessment taken to this point is only indicative of resource quantity and quality. Data users may benefit from a statistical approach that would allow them to better understand the uncertainty and limitations of the sample data. To develop a quantitative approach, geostatistics were applied to the data on coal sulfur content from samples taken in the Pittsburgh coal bed (located in the eastern US, in the southwestern part of the state of Pennsylvania, and in adjoining areas in the states of Ohio and West Virginia). Geostatistical methods that account for regional and local trends were applied to blocks 2.7 mi (4.3 km) on a side. The data and geostatistics support conclusions concerning the average sulfur content and its degree of reliability at regional- and economic-block scale over the large, contiguous part of the Pittsburgh outcrop, but not to a mine scale. To validate the method, a comparison was made with the sulfur contents in sample data taken from 53 coal mines located in the study area. The comparison showed a high degree of similarity between the sulfur content in the mine samples and the sulfur content represented by the geostatistically derived contours. Published by Elsevier Science B.V.

  6. Allegheny County, PA: Mobilizing To Reduce Juvenile Crime.

    ERIC Educational Resources Information Center

    Hsia, Heidi M.

    Juvenile crime and its immediate and long-term economic and human costs have become a national concern. Programs to prevent and reduce delinquency have developed across the country and one such program in Allegheny County, Pennsylvania (which includes Pittsburgh) is described in this bulletin. The Allegheny program exemplifies a large-scale,…

  7. 78 FR 5137 - Safety Zone; Monongahela River, Charleroi, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-24

    ... through Friday, except Federal holidays. FOR FURTHER INFORMATION CONTACT: If you have questions on this...) 366-9826. SUPPLEMENTARY INFORMATION: Table of Acronyms DHS Department of Homeland Security FR Federal... the Port Pittsburgh, or a designated representative. They may be contacted on VHF-FM Channel 13 or...

  8. Evaluating initial spine trauma response: injury time to trauma center in PA, USA.

    PubMed

    Harrop, James S; Ghobrial, George M; Chitale, Rohan; Krespan, Kelly; Odorizzi, Laura; Fried, Tristan; Maltenfort, Mitchell; Cohen, Murray; Vaccaro, Alexander

    2014-10-01

    Historical perceptions regarding the severity of traumatic spinal cord injury has led to considerable disparity in triage to tertiary care centers. This article retrospectively reviews a large regional trauma database to analyze whether the diagnosis of spinal trauma affected patient transfer timing and patterns. The Pennsylvania Trauma database was retrospectively reviewed. All acute trauma patient entries for level I and II centers were categorized for diagnosis, mechanism, and location of injury, analyzing transportation modality and its influence on time of arrival. A total of 1162 trauma patients were identified (1014 blunt injuries, 135 penetrating injuries and 12 other) with a mean transport time of 3.9 hours and a majority of patients arriving within 7 hours (>75%). Spine trauma patients had the longest mean arrival time (5.2 hours) compared to blunt trauma (4.2 hours), cranial neurologic injuries (4.35 hours), and penetrating injuries (2.13 hours, p<0.0001). There was a statistically significant correlation between earlier arrivals and both cranial trauma (p=0.0085) and penetrating trauma (p<0.0001). The fastest modality was a fire rescue (0.93 hours) or police (0.63 hours) vehicle with Philadelphia County (1.1 hour) having the quickest arrival times. Most trauma patients arrived to a specialty center within 7 hours of injury. However subsets analysis revealed that spine trauma patients had the greatest transit times. Present research trials for spinal cord injuries suggest earlier intervention may lead to improved recovery. Therefore, it is important to focus on improvement of the transportation triage system for traumatic spinal patients. PMID:24932590

  9. 76 FR 58327 - Pennsylvania Disaster #PA-00044

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-20

    ... ADMINISTRATION Pennsylvania Disaster PA-00044 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for the Commonwealth of... 76155. FOR FURTHER INFORMATION CONTACT: A. Escobar, Office of Disaster Assistance, U.S. Small...

  10. 76 FR 64419 - Pennsylvania Disaster #PA-00045

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-18

    ... ADMINISTRATION Pennsylvania Disaster PA-00045 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for Public Assistance Only for the... Kingsport Road, Fort Worth, TX 76155. FOR FURTHER INFORMATION CONTACT: A. Escobar, Office of...

  11. 76 FR 58328 - Pennsylvania Disaster #PA-00042

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-20

    ... ADMINISTRATION Pennsylvania Disaster PA-00042 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for the Commonwealth of..., Fort Worth, TX 76155. FOR FURTHER INFORMATION CONTACT: A. Escobar, Office of Disaster Assistance,...

  12. 77 FR 60004 - Pennsylvania Disaster #PA-00053

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-01

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster PA-00053 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY... INFORMATION CONTACT: A. Escobar, Office of Disaster Assistance, U.S. Small Business Administration, 409...

  13. 32 CFR 701.113 - PA exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... DOCUMENTS AFFECTING THE PUBLIC DON Privacy Program § 701.113 PA exemptions. (a) Exempt systems of records. 5 U.S.C. 552a authorizes SECNAV to adopt rules designating eligible systems of records as exempt from... responsible for proposing an exemption rule. Exempt systems of records are identified at...

  14. 78 FR 60366 - Pennsylvania Disaster #PA-00064

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-01

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster PA-00064 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY... Application Deadline Date: 06/24/2014. ADDRESSES: Submit completed loan applications to: U.S. Small...

  15. Seepage Model for PA Including Dift Collapse

    SciTech Connect

    G. Li; C. Tsang

    2000-12-20

    The purpose of this Analysis/Model Report (AMR) is to document the predictions and analysis performed using the Seepage Model for Performance Assessment (PA) and the Disturbed Drift Seepage Submodel for both the Topopah Spring middle nonlithophysal and lower lithophysal lithostratigraphic units at Yucca Mountain. These results will be used by PA to develop the probability distribution of water seepage into waste-emplacement drifts at Yucca Mountain, Nevada, as part of the evaluation of the long term performance of the potential repository. This AMR is in accordance with the ''Technical Work Plan for Unsaturated Zone (UZ) Flow and Transport Process Model Report'' (CRWMS M&O 2000 [153447]). This purpose is accomplished by performing numerical simulations with stochastic representations of hydrological properties, using the Seepage Model for PA, and evaluating the effects of an alternative drift geometry representing a partially collapsed drift using the Disturbed Drift Seepage Submodel. Seepage of water into waste-emplacement drifts is considered one of the principal factors having the greatest impact of long-term safety of the repository system (CRWMS M&O 2000 [153225], Table 4-1). This AMR supports the analysis and simulation that are used by PA to develop the probability distribution of water seepage into drift, and is therefore a model of primary (Level 1) importance (AP-3.15Q, ''Managing Technical Product Inputs''). The intended purpose of the Seepage Model for PA is to support: (1) PA; (2) Abstraction of Drift-Scale Seepage; and (3) Unsaturated Zone (UZ) Flow and Transport Process Model Report (PMR). Seepage into drifts is evaluated by applying numerical models with stochastic representations of hydrological properties and performing flow simulations with multiple realizations of the permeability field around the drift. The Seepage Model for PA uses the distribution of permeabilities derived from air injection testing in niches and in the cross drift to

  16. Fecal-indicator bacteria in the Allegheny, Monongahela, and Ohio Rivers, near Pittsburgh, Pennsylvania, July-September 2001

    USGS Publications Warehouse

    Fulton, John W.; Buckwalter, Theodore F.

    2004-01-01

    This report presents the results of a study by the Allegheny County Health Department (ACHD) and the U.S. Geological Survey (USGS) to determine the concentrations of fecal-indicator bacteria in the Allegheny, Monongahela, and Ohio Rivers (Three Rivers) in Allegheny County, Pittsburgh, Pa. Water-quality samples and river-discharge measurements were collected from July to September 2001 during dry- (72-hour dry antecedent period), mixed-, and wet-weather (48-hour dry antecedent period and at least 0.3 inch of rain in a 6-hour period) conditions at five sampling sites on the Three Rivers in Allegheny County. Water samples were collected weekly to establish baseline conditions and during successive days after three wet-weather events. Water samples were analyzed for fecal-indicator organisms including fecal-coliform (FC) bacteria, Escherichia coli (E. coli), and enterococci bacteria. Water samples were collected by the USGS and analyzed by the ACHD Laboratory. At each site, left-bank and right-bank surface-water samples were collected in addition to a composite sample (discharge-weighted sample representative of the channel cross section as a whole) at each site. Fecal-indicator bacteria reported in bank and composite samples were used to evaluate the distribution and mixing of bacteria-source streams in receiving waters such as the Three Rivers. Single-event concentrations of enterococci, E. coli, and FC during dry-weather events were greater than State and Federal water-quality standards (WQS) in 11, 28, and 28 percent of the samples, respectively; during mixed-weather events, concentrations of fecal-indicator bacteria were greater than WQS in 28, 37, and 43 percent of the samples, respectively; and during wet-weather events, concentrations of fecal-indicator bacteria were greater than WQS in 56, 71, and 81 percent of samples, respectively. Single-event, wet-weather concentrations exceeded those during dry-weather events for all sites except the Allegheny River at

  17. The USA PATRIOT Act.

    ERIC Educational Resources Information Center

    Minow, Mary; Coyle, Karen; Kaufman, Paula

    2002-01-01

    Explains the USA PATRIOT (Uniting and Strengthening America by Providing Appropriate Tools Required to Intercept and Obstruct Terrorism) Act, passed after the September 11 terrorist attacks, and its implications for libraries and patron records. Considers past dealings with the FBI; court orders; search warrants; wiretaps; and subpoenas. Includes:…

  18. CHILD HEALTH USA 2002

    EPA Science Inventory

    Child Health USA 2002, the thirteenth annual report on the health status and service needs of America's children is presented by the Health Resources and Services Administration's Maternal and Child Health Bureau (MCHB). To assess the bureau's progress toward achieving its vision...

  19. Cape Cod, Massachusetts, USA

    NASA Technical Reports Server (NTRS)

    1990-01-01

    This view of Cape Cod, Massachusetts, USA (42.0N, 70.0W) is a detailed look at the national seashore recreation area with its many fine resorts and summer estate homes. Geologically, the cape is a deposit of earth and stone called a terminal moraine, left by the great Pleistocene glaciers of about 20,000 years ago.

  20. Cape Cod, Massachusetts, USA

    NASA Technical Reports Server (NTRS)

    1990-01-01

    This view of Cape Cod, Massachusetts, USA (42.0N, 70.5W) is a detailed look at the national seashore recreation area with its many fine resorts and summer estate homes. Geologically, the cape is a deposit of earth and stone called a terminal moraine, left by the great Pleistocene glaciers of about 20,000 years ago.

  1. Technical Insights for Saltstone PA Maintenance

    SciTech Connect

    Flach, G.; Sarkar, S.; Mahadevan, S.; Kosson, D.

    2011-07-20

    The Cementitious Barriers Partnership (CBP) is a collaborative program sponsored by the US DOE Office of Waste Processing. The objective of the CBP is to develop a set of computational tools to improve understanding and prediction of the long-term structural, hydraulic, and chemical performance of cementitious barriers and waste forms used in nuclear applications. CBP tools are expected to better characterize and reduce the uncertainties of current methodologies for assessing cementitious barrier performance and increase the consistency and transparency of the assessment process, as the five-year program progresses. In September 2009, entering its second year of funded effort, the CBP sought opportunities to provide near-term tangible support to DOE Performance Assessments (PAs). The Savannah River Saltstone Disposal Facility (SDF) was selected for the initial PA support effort because (1) cementitious waste forms and barriers play a prominent role in the performance of the facility, (2) certain important long-term behaviors of cementitious materials composing the facility are uncertain, (3) review of the SDF PA by external stakeholders is ongoing, and (4) the DOE contractor responsible for the SDF PA is open to receiving technical assistance from the CBP. A review of the current (SRR Closure & Waste Disposal Authority 2009) and prior Saltstone PAs (e.g., Cook et al. 2005) suggested five potential opportunities for improving predictions. The candidate topics considered were (1) concrete degradation from external sulfate attack, (2) impact of atmospheric exposure to concrete and grout before closure, such as accelerated slag and Tc-99 oxidation, (3) mechanistic prediction of geochemical conditions, (4) concrete degradation from rebar corrosion due to carbonation, and (5) early age cracking from drying and/or thermal shrinkage. The candidate topics were down-selected considering the feasibility of addressing each issue within approximately six months, and

  2. Clinicopathologic and 11C-Pittsburgh compound B implications of Thal amyloid phase across the Alzheimer’s disease spectrum

    PubMed Central

    Lowe, Val J.; Graff-Radford, Neill R.; Liesinger, Amanda M.; Cannon, Ashley; Przybelski, Scott A.; Rawal, Bhupendra; Parisi, Joseph E.; Petersen, Ronald C.; Kantarci, Kejal; Ross, Owen A.; Duara, Ranjan; Knopman, David S.; Jack, Clifford R.; Dickson, Dennis W.

    2015-01-01

    Thal amyloid phase, which describes the pattern of progressive amyloid-β plaque deposition in Alzheimer’s disease, was incorporated into the latest National Institute of Ageing – Alzheimer’s Association neuropathologic assessment guidelines. Amyloid biomarkers (positron emission tomography and cerebrospinal fluid) were included in clinical diagnostic guidelines for Alzheimer’s disease dementia published by the National Institute of Ageing – Alzheimer’s Association and the International Work group. Our first goal was to evaluate the correspondence of Thal amyloid phase to Braak tangle stage and ante-mortem clinical characteristics in a large autopsy cohort. Second, we examined the relevance of Thal amyloid phase in a prospectively-followed autopsied cohort who underwent ante-mortem 11C-Pittsburgh compound B imaging; using the large autopsy cohort to broaden our perspective of 11C-Pittsburgh compound B results. The Mayo Clinic Jacksonville Brain Bank case series (n = 3618) was selected regardless of ante-mortem clinical diagnosis and neuropathologic co-morbidities, and all assigned Thal amyloid phase and Braak tangle stage using thioflavin-S fluorescent microscopy. 11C-Pittsburgh compound B studies from Mayo Clinic Rochester were available for 35 participants scanned within 2 years of death. Cortical 11C-Pittsburgh compound B values were calculated as a standard uptake value ratio normalized to cerebellum grey/white matter. In the high likelihood Alzheimer’s disease brain bank cohort (n = 1375), cases with lower Thal amyloid phases were older at death, had a lower Braak tangle stage, and were less frequently APOE-ε4 positive. Regression modelling in these Alzheimer’s disease cases, showed that Braak tangle stage, but not Thal amyloid phase predicted age at onset, disease duration, and final Mini-Mental State Examination score. In contrast, Thal amyloid phase, but not Braak tangle stage or cerebral amyloid angiopathy predicted 11C-Pittsburgh compound

  3. Male mental health problems, psychopathy, and personality traits: key findings from the first 14 years of the Pittsburgh Youth Study.

    PubMed

    Loeber, R; Farrington, D P; Stouthamer-Loeber, M; Moffitt, T E; Caspi, A; Lynam, D

    2001-12-01

    This paper reviews key findings on juvenile mental health problems in boys, psychopathy, and personality traits, obtained in the first 14 years of studies using data from the Pittsburgh Youth Study. This is a study of 3 samples, each of about 500 boys initially randomly drawn from boys in the 1st, 4th, and 7th grades of public schools in Pittsburgh. The boys have been followed regularly, initially each half year, and later at yearly intervals. Currently, the oldest boys are about 25 years old, whereas the youngest boys are about 19. Findings are presented on the prevalence and interrelation of disruptive behaviors, ADHD, and depressed mood. Results concerning risk factors for these outcomes are reviewed. Psychological factors such as psychopathy, impulsivity, and personality are described. The paper closes with findings on service delivery of boys with mental health problems. PMID:11837460

  4. Clinicopathologic and 11C-Pittsburgh compound B implications of Thal amyloid phase across the Alzheimer's disease spectrum.

    PubMed

    Murray, Melissa E; Lowe, Val J; Graff-Radford, Neill R; Liesinger, Amanda M; Cannon, Ashley; Przybelski, Scott A; Rawal, Bhupendra; Parisi, Joseph E; Petersen, Ronald C; Kantarci, Kejal; Ross, Owen A; Duara, Ranjan; Knopman, David S; Jack, Clifford R; Dickson, Dennis W

    2015-05-01

    Thal amyloid phase, which describes the pattern of progressive amyloid-β plaque deposition in Alzheimer's disease, was incorporated into the latest National Institute of Ageing - Alzheimer's Association neuropathologic assessment guidelines. Amyloid biomarkers (positron emission tomography and cerebrospinal fluid) were included in clinical diagnostic guidelines for Alzheimer's disease dementia published by the National Institute of Ageing - Alzheimer's Association and the International Work group. Our first goal was to evaluate the correspondence of Thal amyloid phase to Braak tangle stage and ante-mortem clinical characteristics in a large autopsy cohort. Second, we examined the relevance of Thal amyloid phase in a prospectively-followed autopsied cohort who underwent ante-mortem (11)C-Pittsburgh compound B imaging; using the large autopsy cohort to broaden our perspective of (11)C-Pittsburgh compound B results. The Mayo Clinic Jacksonville Brain Bank case series (n = 3618) was selected regardless of ante-mortem clinical diagnosis and neuropathologic co-morbidities, and all assigned Thal amyloid phase and Braak tangle stage using thioflavin-S fluorescent microscopy. (11)C-Pittsburgh compound B studies from Mayo Clinic Rochester were available for 35 participants scanned within 2 years of death. Cortical (11)C-Pittsburgh compound B values were calculated as a standard uptake value ratio normalized to cerebellum grey/white matter. In the high likelihood Alzheimer's disease brain bank cohort (n = 1375), cases with lower Thal amyloid phases were older at death, had a lower Braak tangle stage, and were less frequently APOE-ε4 positive. Regression modelling in these Alzheimer's disease cases, showed that Braak tangle stage, but not Thal amyloid phase predicted age at onset, disease duration, and final Mini-Mental State Examination score. In contrast, Thal amyloid phase, but not Braak tangle stage or cerebral amyloid angiopathy predicted (11)C-Pittsburgh compound B

  5. {sup 231}Pa photofission cross section

    SciTech Connect

    Soldatov, A.S.; Rudnikov, V.E.; Smirenkin, G.N.

    1995-12-01

    The measurements of the {sup 231}Pa yield and cross section photofission in the energy range 7-9 MeV are presented. These measurements are a continuation of similar measurements performed for the {gamma}-ray energy range 4.8-7 MeV. The entire collection of experimental data which combine the results obtained in the present work and in Ref. 1 was analyzed.

  6. Graphs for Isotopes of 91-Pa (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides a graphic representation of nucleon separation energies and residual interaction parameters for isotopes of the chemical element 91-Pa (Protactinium, atomic number Z = 91).

  7. Indoor radon levels in Cumberland County, PA

    SciTech Connect

    Cohen, B.L.; Nason, R.

    1987-01-01

    Measurements were made of radon levels in 165 randomly selected homes in Cumberland County, PA during Winter 1984-1985. The average and mean levels were found to be 9.1 +/- 0.7 pCi/L and 6.3 +/- 0.5 pCi/L, respectively, many times normally encountered levels. Average and mean radon levels are reported vs. various house characteristics. 4 references, 1 figure, 6 tables.

  8. Sensor Kinase PA4398 Modulates Swarming Motility and Biofilm Formation in Pseudomonas aeruginosa PA14

    PubMed Central

    Strehmel, Janine; Neidig, Anke; Nusser, Michael; Geffers, Robert; Brenner-Weiss, Gerald

    2014-01-01

    Pseudomonas aeruginosa is an opportunistic human pathogen that is able to sense and adapt to numerous environmental stimuli by the use of transcriptional regulators, including two-component regulatory systems. In this study, we demonstrate that the sensor kinase PA4398 is involved in the regulation of swarming motility and biofilm formation in P. aeruginosa PA14. A PA4398− mutant strain was considerably impaired in swarming motility, while biofilm formation was increased by approximately 2-fold. The PA4398− mutant showed no changes in growth rate, rhamnolipid synthesis, or the production of the Pel exopolysaccharide but exhibited levels of the intracellular second messenger cyclic dimeric GMP (c-di-GMP) 50% higher than those in wild-type cells. The role of PA4398 in gene regulation was investigated by comparing the PA4398− mutant to the wild-type strain by using microarray analysis, which demonstrated that 64 genes were up- or downregulated more than 1.5-fold (P < 0.05) under swarming conditions. In addition, more-sensitive real-time PCR studies were performed on genes known to be involved in c-di-GMP metabolism. Among the dysregulated genes were several involved in the synthesis and degradation of c-di-GMP or in the biosynthesis, transport, or function of the iron-scavenging siderophores pyoverdine and pyochelin, in agreement with the swarming phenotype observed. By analyzing additional mutants of selected pyoverdine- and pyochelin-related genes, we were able to show that not only pvdQ but also pvdR, fptA, pchA, pchD, and pchH are essential for the normal swarming behavior of P. aeruginosa PA14 and may also contribute to the swarming-deficient phenotype of the PA4398− mutant in addition to elevated c-di-GMP levels. PMID:25501476

  9. Reconstruction of the 1994 Pittsburgh Airplane Accident Using a Computer Simulation

    NASA Technical Reports Server (NTRS)

    Parks, Edwin K.; Bach, Ralph E., Jr.; Shin, Jae Ho

    1998-01-01

    On September 8, 1994, a Boeing 737-300 passenger airplane was on a downwind approach to the Pittsburgh International Airport at an altitude of 5000 feet above ground level (6000 feet MSL). While in a shallow left turn onto a downwind approach heading, the airplane crossed into the vortex trail of a Boeing 727 flying in the same approach pattern about 4 miles ahead. The B-737 airplane rolled and turned sharply to the left, exited the vortex wake and plunged into the ground. Weather was not a factor in the accident. The airplane was equipped with a 11+ channel digital Flight Data Recorder (FDR) and a multiple channel Cockpit Voice Recorder (CVR). Both recorders were recovered from the crash site and provided excellent data for the development of an accident scenario. Radar tracking of the two airplanes as well as the indicated air speed (IAS) perturbations clearly visible on the B-737 FDR recordings indicate that the upset was apparently initiated by the airplane's crossing into the wake of the B-727 flying ahead in the same traffic pattern. A 6 degree-of-freedom simulation program for the B-737 airplane using MATLAB and SIMULINK was constructed. The simulation was initialized at the stabilized flight conditions of the airplane about 13 seconds prior to its entry into the vortex trail of the B-727 airplane. By assuming a certain combination of control inputs, it was possible to produce a simulated motion that closely matched that recorded on the FDR.

  10. 1996 environmental monitoring report for the Bettis Atomic Power Laboratory, Pittsburgh Site

    SciTech Connect

    1996-12-31

    The 1996 results for the Bettis-Pittsburgh radiological and non-radiological environmental monitoring programs are presented. The primary mission of the Bettis Laboratory has been directed toward the design, development, testing, and operation of nuclear reactor propulsion plants for naval surface and submarine vessels. The results obtained from the monitoring programs demonstrate that the existing procedures ensured that releases to the environment during 1996 were in accordance with applicable federal, state, county, and local regulations. Evaluation of the environmental data indicated that the current operations at the Site continue to have no adverse effect on the quality of the environment. A conservative assessment of radiation exposure to the general public as a result of Site operations demonstrated that the dose received by any member of the public was well below the most restrictive dose limits established by the Environmental Protection Agency, the Nuclear Regulatory Commission and the US Department of Energy. A risk assessment of potentially exposed populations to chemical residues in the environment at the Site demonstrated that these residues do not pose any significant health risk.

  11. Nonstandard Programs: the University of Pittsburgh Medical Center's next frontier in graduate medical education.

    PubMed

    Kroboth, Frank J; Zerega, W Dennis; Patel, Rita M; Barnes, Barbara E; Webster, Marshall W

    2011-02-01

    The University of Pittsburgh Medical Center has seen continuous growth in the number and types of graduate training programs not accredited by the Accreditation Council for Graduate Medical Education (ACGME), the American Board of Medical Specialties, or the American Osteopathic Association. For the purposes of ensuring best educational products and of controlling unrecognized competition with our accredited programs, a sequential process of centralized oversight of these nonstandard programs was undertaken. The first step involved programs whose fellows were hired and tracked like accredited fellows (i.e., not instructors). The basic process began with consensus among leadership, writing of policy with consultation as necessary, establishment of a registry of programs and graduates, and a committee to allow sharing of best practices and dissemination of policy. The second step applied the same process to instructor-level programs. Whereas the previous group of programs was made subject to ACGME regulations, more latitude in duty hours and progressive responsibility were allowed for instructor programs. The final step, in progress, is extending a similar but modified approach to short-duration clinical experiences and observerships. The outcomes of these efforts have been the creation of a centralized organizational structure, policies to guide this structure, an accurate registry of a surprising number of training programs, and a rolling record of all graduates from these programs. Included in the process is a mechanism that ensures that core program directors and department chairs specifically review the impact of new programs on core programs before allowing their creation. PMID:21169779

  12. Recombinant α1-Antitrypsin Pittsburgh Attenuates Experimental Gram-Negative Septicemia

    PubMed Central

    Colman, Robert W.; Flores, Daniel N.; De La Cadena, Raul A.; Scott, Cheryl F.; Cousens, Laurence; Barr, Philip J.; Hoffman, Ian B.; Kueppers, Friedrich; Fisher, Donald; Idell, Steven; Pisarello, Jorge

    1988-01-01

    Alpha1-antitrypsin-Pittsburgh (AT-P), a naturally occurring lethal mutation (358Met → Arg), has been genetically engineered (rAT-P). The protein has been shown to be a potent active site-directed inhibitor of thrombin and the contact enzymes Factor XIIf, Factor XIa, and kallikrein. Because activation of the contact system is known to occur in gram-negative septicemia, the authors have hypothesized that the administration of rAT-P might modulate the course of this syndrome. Yorkshire piglets anesthetized with pentobarbital and infused with viable Pseudomonas aeruginosa (2 X 108 CFU) were untreated (Group I) or treated with rAT-P (Group II) and studied in a 6-hour protocol. Coagulation studies revealed that rAT-P significantly inhibited the rapid decrease in the functional concentrations of Antithrombin III, Factor XI, and fibrinogen. In addition, rAT-P markedly reduced the serum levels of fibrinogen degradation products. Survival in Group II was significantly increased during 2-5 hours but not at 6 hours when the functional levels of rAT-P in plasma were the lowest. These results indicate that this recombinant inhibitor, even at low concentrations, affords protection in experimental gram-negative septicemia. PMID:3257651

  13. Health hazard evaluation report No. HETA 90-010-2170, LTV Steel Company, Pittsburgh, Pennsylvania

    SciTech Connect

    Kinnes, G.M.; Letts, D.

    1991-12-01

    In response to a request from the United Steelworkers of America, an investigation was made of possible causative agents for allergic contact dermatitis in workers who clean the coke oven gas inlets at the LTV Steel Company (SIC-3312), Pittsburgh, Pennsylvania. The LTV Steel coke oven facility consists of five batteries, with a total of 315 by-product ovens. Almost 3 years ago a skin problem of potential occupational origin was identified among the heaters, helpers and patchers. A list of 26 workers with skin problems was developed by the union and management and provided to NIOSH investigators. The suspected causative agent was a condensate from coke oven underfiring gas which collected on gas nozzle seats in the gas heating pipes of specific batteries. The nine employees diagnosed as having occupational allergic contact dermatitis tested positive to at least one of the coke oven gas condensate fractions. Many compounds were identified in the condensate sample. The authors conclude that the dermatitis in some workers was probably caused by contact with the coke oven gas condensates. The authors recommend measures intended to prevent contact with the condensates.

  14. Associations between Pittsburgh Sleep Quality Index Factors and Health Outcomes in Women with Posttraumatic Stress Disorder

    PubMed Central

    Casement, Melynda D.; Harrington, Kelly M.; Miller, Mark W.; Resick, Patricia A.

    2012-01-01

    Objective The Pittsburgh Sleep Quality Index (PSQI) is a widely used measure of subjective sleep disturbance in clinical populations, including individuals with posttraumatic stress disorder (PTSD). Although the severity of sleep disturbance is generally represented by a global symptom score, recent factor analytic studies suggest that the PSQI is better characterized by a two- or three-factor model than a one-factor model. This study examined the replicability of two- and three-factor models of the PSQI, as well as the relationship between PSQI factors and health outcomes, in a female sample with PTSD. Methods The PSQI was administered to 319 women with PTSD related to sexual or physical assault. Confirmatory factor analyses tested the relative fit of one-, two-, and three-factor solutions. Bivariate correlations were performed to examine the shared variance between PSQI sleep factors and measures of PTSD, depression, anger, and physical symptoms. Results Confirmatory factor analyses supported a 3-factor model with Sleep Efficiency, Perceived Sleep Quality, and Daily Disturbances as separate indices of sleep quality. The severity of symptoms represented by the PSQI factors was positively associated with the severity of PTSD, depression, and physical symptoms. However, these health outcomes correlated as much or more with the global PSQI score as with PSQI factor scores. Conclusions These results support the multidimensional structure of the PSQI. Yet, the global PSQI score has as much or more explanatory power as individual PSQI factors in predicting health outcomes. PMID:22542787

  15. Proteasome activators, PA28γ and PA200, play indispensable roles in male fertility

    PubMed Central

    Huang, Lin; Haratake, Kousuke; Miyahara, Hatsumi; Chiba, Tomoki

    2016-01-01

    Protein degradation mediated by the proteasome is important for the protein homeostasis. Various proteasome activators, such as PA28 and PA200, regulate the proteasome function. Here we show double knockout (dKO) mice of Psme3 and Psme4 (genes for PA28γ and PA200), but not each single knockout mice, are completely infertile in male. The dKO sperms exhibited remarkable defects in motility, although most of them showed normal appearance in morphology. The proteasome activity of the mutant sperms decreased notably, and the sperms were strongly positive with ubiquitin staining. Quantitative analyses of proteins expressed in dKO sperms revealed up-regulation of several proteins involved in oxidative stress response. Furthermore, increased 8-OHdG staining was observed in dKO sperms head, suggesting defective response to oxidative damage. This report verified PA28γ and PA200 play indispensable roles in male fertility, and provides a novel insight into the role of proteasome activators in antioxidant response. PMID:27003159

  16. Final report on EURAMET.M.P-S12 — Bilateral supplementary comparison of the national pressure standards of CMI and INRIM in the range 300 Pa to 15 kPa of negative gauge pressure

    NASA Astrophysics Data System (ADS)

    Krajícek, Zdenek; Bergoglio, Mercede; Pražák, Dominik; Pasqualin, Stefano

    2014-01-01

    This report describes a EURAMET bilateral supplementary comparison between Czech CMI and Italian INRIM in low negative gauge pressure in gas (nitrogen), denoted as EURAMET.M.P-S12. The digital non-rotating pressure balance FPG8601 manufactured by Fluke/DH-Instruments, USA is normally used for gauge and absolute pressures in the range from 1 Pa to 15 kPa, but with some modifications it can be used also for the negative gauge pressures in the same range. During the preparation of the visit of INRIM at CMI for the last comparison within the framework of EURAMET.M.P-K4.2010, it was agreed to also perform an additional comparison in the range from 300 Pa to 15 kPa of negative gauge pressure. The measurements were performed in October 2012. Both institutes successfully proved their equivalence in all the tested points in the range from 300 Pa to 15 kPa of negative gauge pressure in a comparison that had, so far, been unique. . Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

  17. Sensor kinase PA4398 modulates swarming motility and biofilm formation in Pseudomonas aeruginosa PA14.

    PubMed

    Strehmel, Janine; Neidig, Anke; Nusser, Michael; Geffers, Robert; Brenner-Weiss, Gerald; Overhage, Joerg

    2015-02-01

    Pseudomonas aeruginosa is an opportunistic human pathogen that is able to sense and adapt to numerous environmental stimuli by the use of transcriptional regulators, including two-component regulatory systems. In this study, we demonstrate that the sensor kinase PA4398 is involved in the regulation of swarming motility and biofilm formation in P. aeruginosa PA14. APA4398 mutant strain was considerably impaired in swarming motility, while biofilm formation was increased by approximately 2-fold. The PA4398 mutant showed no changes in growth rate, rhamnolipid synthesis, or the production of the Pel exopolysaccharide but exhibited levels of the intracellular second messenger cyclic dimeric GMP (c-di-GMP) 50% higher than those in wild-type cells. The role of PA4398 in gene regulation was investigated by comparing the PA4398 mutant to the wildtype strain by using microarray analysis, which demonstrated that 64 genes were up- or downregulated more than 1.5-fold (P<0.05) under swarming conditions. In addition, more-sensitive real-time PCR studies were performed on genes known to be involved in c-di-GMP metabolism. Among the dysregulated genes were several involved in the synthesis and degradation of c-di-GMP or in the biosynthesis, transport, or function of the iron-scavenging siderophores pyoverdine and pyochelin, in agreement with the swarming phenotype observed. By analyzing additional mutants of selected pyoverdine- and pyochelin-related genes,we were able to show that not only pvdQ but also pvdR, fptA, pchA, pchD, and pchH are essential for the normal swarming behavior of P. aeruginosa PA14 and may also contribute to the swarming-deficient phenotype of the PA4398 mutant in addition to elevated c-di-GMP levels. PMID:25501476

  18. American Uveitis Society Meeting October 30, 1995 Marriott Marquis Hotel, Atlanta, GA, USA.

    PubMed

    Meisler, D M; Chern, K C

    1996-01-01

    1 Retinal vascular occlusion and scleroderma. Tessler H, Flores-Guevara J, Goldstein D, Chicago, IL, USA. 2 MHC Class II antigen expression in ciliary body in spontaneous and experimental uveitis. Kalsow C, Zhavoronkova M, Dwyer A, Rochester, NY & Scottsville, NY, USA. 3 IL-10 in the vitreous of patients with intraocular lymphoma. Whitcup S, Solomon D, Nussenblatt R, Chan C-C, Bethesda, MD, USA 4 Iris juvenile xanthogranuloma studied by immunohistochemistry. Shields J, Shields C, Eagle R, DePotter P, Collins M, Philadelphia, PA, USA. 5 Outcomes analysis in with JRA-associated uveitis. Dana M-R, Merayo-Lloves J, Foster C, Boston MA, USA. 6 Persistent glaucoma secondary to periocular steroids. Akduman L, Conway M, Burchfield J, Kolker A, Black D, DelPriore L, Kaplan H, St. Louis, MO, USA 7 The use of itraconazole in ocular histoplasmosis Callanan D, Fish G, Dallas, TX, USA 8 Succesful treatment of macular hole secondary to sympathetic ophthalmia. Cano J, Diaz M, Navea A, Ruiz C, Castilla M. Barcelona, Spain. 9 HLA-DR2+ intermediate uveitis. Pulido J, Tang W, Han D, Mieler W. Milwaukee, WI, USA. 10 Vein occlusion in AIDS misdiagnosed as CMV retinitis. Park K, Marx J, Rao N. Los Angeles, CA, USA. 11 HIV-associated foveal hemorrhage. Crews K, Zimmerman P, Lohner S. Salt Lake City, UT, USA. 12 Cytomegalovirus papillitis in patients with AIDS. Patel S, Rutzen A, Marx J, Thach A, Chong L, Rao N, Los Angeles, CA, USA. 13 Recurrence rate of CMV retinitis following the ganciclovir implant and pars plans vitrectomy and silicone oil. Marx J, Thach A, Rao N, Chong L. Los Angeles, CA, USA. PMID:22827419

  19. Description of interview data regarding Pittsburgh and confluence toxic chemical accidents

    SciTech Connect

    Rogers, G.O.; Shumpert, B.L.; Sorensen, J.H.

    1990-11-01

    Evacuation is the protective action most often recommended in response to chemical releases in the United States. The appropriateness of a decision to evacuate depends on whether the affected areas can be cleared of residents before it is contaminated by the chemical release. In determining whether an evacuation can be completed in time, emergency officials must consider both technical and behavioral aspects. The technical components can be readily conceived and quantified. In contrast, the behavioral components are much more abstract and more difficult to estimate. This report summarizes the univariate analysis of responses to surveys conducted in two communities where evacuation was recommended following train derailments involving hazardous chemicals. The surveys were designed to identify the actions taken by residents upon receiving the emergency warning; determine when people received the warning, decided to take action, and implemented the action; and ascertain factors that might explain the nature and timing of their actions. The surveys were conducted in the Bloomfield section of Pittsburgh, Pennsylvania, and in the town of Confluence, Pennsylvania. The study confirms that compliance with an emergency warning to evacuate varies and that potentially dangerous delays can be expected. Significant differences were noted, however, in the rate and speed of compliance in the two communities. The surveys provide information on several factors that may be useful in determining the reasons for differences in the responses from the two communities as well as differences among individual respondents. Such factors include the time of day when the accident occurred, where the respondent was at the time, whether the family was together, previous disaster experience, pet ownership, the content of the warning message, and demographic characteristics. 4 refs., 4 figs., 18 tabs.

  20. Validity of the Pittsburgh Sleep Quality Index in Indian University Students

    PubMed Central

    Manzar, Md. Dilshad; Moiz, Jamal A.; Zannat, Wassilatul; Spence, David W.; Pandi-Perumal, Seithikurippu R.; Hussain, M. Ejaz

    2015-01-01

    Objectives Despite the demonstrated utility of the Pittsburgh Sleep Quality Index (PSQI) in various demographic groups, it has never been validated in a sample of Indian subjects. To extend and confirm the PSQI’s applicability for South Asian subjects, this preliminary study aimed to assess its psychometric and diagnostic validity in a sample of university students. Methods Forty-seven male students were recruited from Jamia Millia Islamia, a public central university in New Delhi, India. The mean age of the students was 23.4±3.9 years, and they had a mean body mass index (BMI) of 23.3±3.3kg/m2. The PSQI was administered to all subjects and overnight polysomnographic testing was carried out as a concurrent validation measure. Results Cronbach’s alpha for the questionnaire was found to be 0.736. Internal homogeneity was high, with the majority of correlations between questionnaire component scores and the summed global score being significant (p<0.010). Criterion validity-correlations between the PSQI global score and polysomnography (PSG) measures were low. However, the questionnaire component scores and the related polysomnographic measures did show some significant relationships. The optimal cut-off scores for distinguishing students with/without sleep problems was >6 and was generated using receiver operating characteristic curve analysis. The area under the curve, sensitivity, specificity, positive and negative likelihood ratios at the cut-off score were 0.838 (p<0.0001), 75.0%, 88.9%, 6.75, and 0.280, respectively. Conclusion The study found evidence that the PSQI had internal consistency, internal homogeneity, and diagnostic characteristics that compared well with PSG among a sample of young adult male students in India. This supports the applicability and certain aspects of the validity of the PSQI in the population. PMID:26171126

  1. 42. Drawing entitled Atwater Kent Mfg. Co., Philadelphia, Pa., Plant ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    42. Drawing entitled Atwater Kent Mfg. Co., Philadelphia, Pa., Plant No. 7, Office Entrances, Wissahickon Avenue. The Ballinger Company - Atwater Kent Manufacturing Company, North Plant, 5000 Wissahickon Avenue, Philadelphia, Philadelphia County, PA

  2. 41. Drawing entitled Atwater Kent Mfg. Co., Philadelphia, Pa., Plant ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    41. Drawing entitled Atwater Kent Mfg. Co., Philadelphia, Pa., Plant No. 7, Elevation and Plan of Bridge. The Ballinger Company (1928) - Atwater Kent Manufacturing Company, North Plant, 5000 Wissahickon Avenue, Philadelphia, Philadelphia County, PA

  3. 38. Drawing entitled Atwater Kent Mfg. Co., Philadelphia, Pa., Plant ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    38. Drawing entitled Atwater Kent Mfg. Co., Philadelphia, Pa., Plant No. 7, First Story. The Ballinger Company (1928) - Atwater Kent Manufacturing Company, North Plant, 5000 Wissahickon Avenue, Philadelphia, Philadelphia County, PA

  4. 7. B & O RAILROAD BRIDGE. PHILADELPHIA, PHILADELPHIA CO., PA. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. B & O RAILROAD BRIDGE. PHILADELPHIA, PHILADELPHIA CO., PA. Sec. 1101, MP 3.11. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  5. 5. ISLAND ROAD BRIDGE. COLWYN, DELAWARE CO., PA. Sec. 1101, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. ISLAND ROAD BRIDGE. COLWYN, DELAWARE CO., PA. Sec. 1101, MP 5.58. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  6. 4. COBBS CREEK BRIDGE. COLWYN, DELAWARE CO., PA. Sec. 1101, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. COBBS CREEK BRIDGE. COLWYN, DELAWARE CO., PA. Sec. 1101, MP 5.73 - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  7. 6. B & O RAILROAD BRIDGE. PHILADELPHIA, PHILADELPHIA CO., PA. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. B & O RAILROAD BRIDGE. PHILADELPHIA, PHILADELPHIA CO., PA. Sec. 1101, MP 3.11. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  8. 20. Zoo Substation. Philadelphia, Philadelphia Co., PA. Sec. 1101, MP ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    20. Zoo Substation. Philadelphia, Philadelphia Co., PA. Sec. 1101, MP 87.25. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  9. Cape Cod, Massachusetts, USA

    NASA Technical Reports Server (NTRS)

    1990-01-01

    Cape Cod, Massachusetts, USA (42.0N, 70.5W) is a national seashore recreation area with many fine resorts and summer estate homes. Geologically, the cape is a deposit of earth and stone called a terminal moraine, left by the great Pleistocene glaciers of about 20,000 years ago. The through canal at the base of the cape is a manmade feature for waterborne traffic and is part of the Intercoastal Canal network. The cape actually begins south of the canal.

  10. PaDe - The particle detection program

    NASA Astrophysics Data System (ADS)

    Ott, T.; Drolshagen, E.; Koschny, D.; Poppe, B.

    2016-01-01

    This paper introduces the Particle Detection program PaDe. Its aim is to analyze dust particles in the coma of the Jupiter-family comet 67P/Churyumov-Gerasimenko which were recorded by the two OSIRIS (Optical, Spectroscopic, and Infrared Remote Imaging System) cameras onboard the ESA spacecraft Rosetta, see e.g. Keller et al. (2007). In addition to working with the Rosetta data, the code was modified to work with images from meteors. It was tested with data recorded by the ICCs (Intensified CCD Cameras) of the CILBO-System (Canary Island Long-Baseline Observatory) on the Canary Islands; compare Koschny et al. (2013). This paper presents a new method for the position determination of the observed meteors. The PaDe program was written in Python 3.4. Its original intent is to find the trails of dust particles in space from the OSIRIS images. For that it determines the positions where the trail starts and ends. They were found using a fit following the so-called error function (Andrews, 1998) for the two edges of the profiles. The positions where the intensities fall to the half maximum were found to be the beginning and end of the particle. In the case of meteors, this method can be applied to find the leading edge of the meteor. The proposed method has the potential to increase the accuracy of the position determination of meteors dramatically. Other than the standard method of finding the photometric center, our method is not influenced by any trails or wakes behind the meteor. This paper presents first results of this ongoing work.

  11. Parrot Bornavirus (PaBV)-2 isolate causes different disease patterns in cockatiels than PaBV-4.

    PubMed

    Piepenbring, Anne K; Enderlein, Dirk; Herzog, Sibylle; Al-Ibadi, Basim; Heffels-Redmann, Ursula; Heckmann, Julia; Lange-Herbst, Hildburg; Herden, Christiane; Lierz, Michael

    2016-01-01

    Psittaciform 1 bornavirus (PaBV) has already been shown to be the aetiologic agent of proventricular dilatation disease, a significant disease of birds. However, the pathogenesis of PaBV infection has not yet been resolved and valid data regarding the pathogenicity of different PaBV species are lacking. Thus, the present study was aimed to characterize the influence of two different PaBV species on the course of disease. Eighteen cockatiels were inoculated intracerebrally (i.c.) or intravenously (i.v.) with a PaBV-2 isolate under the same conditions as in a previous study using PaBV-4. Birds were surveyed and sampled for 33 weeks to analyse the course of infection and disease in comparison to that of PaBV-4. Similar to PaBV-4, PaBV-2 induced a persistent infection with seroconversion (from day 6 p.i. onwards) and shedding of viral RNA (from day 27 p.i. onwards). However, in contrast to PaBV-4, more birds displayed clinical signs and disease progression was more severe. After PaBV-2 infection, 12 birds exhibited clinical signs and 10 birds revealed a dilated proventriculus in necropsy. After PaBV-4 infection only four birds revealed clinical signs and seven birds showed a dilatation of the proventriculus. Clinically, different courses of disease were observed after PaBV-2 infection, mainly affecting the gastrointestinal tract. This had not been detected after PaBV-4 infection where more neurological signs were noted. The results provide evidence for different disease patterns according to different PaBV species, allowing the comparison between the infection with two PaBV species, and thus underlining the role of viral and individual host factors for disease outcome. PMID:27100150

  12. Simplified Space Conditioning in Low-Load Homes: Results from Pittsburgh, Pennsylvania, New Construction Unoccupied Test House

    SciTech Connect

    Poerschke, A.; Stecher, D.

    2014-06-01

    Field testing was performed in a new construction unoccupied test house in Pittsburgh, Pennsylvania. Four air-based heating, ventilation, and air conditioning distribution systems--a typical airflow ducted system to the bedrooms, a low airflow ducted system to the bedrooms, a system with transfer fans to the bedrooms, and a system with no ductwork to the bedrooms--were evaluated during heating, cooling, and midseason conditions. The relative ability of each system was assessed with respect to relevant Air Conditioning Contractors of America and ASHRAE standards for house temperature uniformity and stability, respectively.

  13. Indoor air sampling for fine particulate matter and black carbon in industrial communities in Pittsburgh.

    PubMed

    Tunno, Brett J; Naumoff Shields, Kyra; Cambal, Leah; Tripathy, Sheila; Holguin, Fernando; Lioy, Paul; Clougherty, Jane E

    2015-12-01

    Impacts of industrial emissions on outdoor air pollution in nearby communities are well-documented. Fewer studies, however, have explored impacts on indoor air quality in these communities. Because persons in northern climates spend a majority of their time indoors, understanding indoor exposures, and the role of outdoor air pollution in shaping such exposures, is a priority issue. Braddock and Clairton, Pennsylvania, industrial communities near Pittsburgh, are home to an active steel mill and coke works, respectively, and the population experiences elevated rates of childhood asthma. Twenty-one homes were selected for 1-week indoor sampling for fine particulate matter (PM2.5) and black carbon (BC) during summer 2011 and winter 2012. Multivariate linear regression models were used to examine contributions from both outdoor concentrations and indoor sources. In the models, an outdoor infiltration component explained 10 to 39% of variability in indoor air pollution for PM2.5, and 33 to 42% for BC. For both PM2.5 models and the summer BC model, smoking was a stronger predictor than outdoor pollution, as greater pollutant concentration increases were identified. For winter BC, the model was explained by outdoor pollution and an open windows modifier. In both seasons, indoor concentrations for both PM2.5 and BC were consistently higher than residence-specific outdoor concentration estimates. Mean indoor PM2.5 was higher, on average, during summer (25.8±22.7 μg/m3) than winter (18.9±13.2 μg/m3). Contrary to the study's hypothesis, outdoor concentrations accounted for only little to moderate variability (10 to 42%) in indoor concentrations; a much greater proportion of PM2.5 was explained by cigarette smoking. Outdoor infiltration was a stronger predictor for BC compared to PM2.5, especially in winter. Our results suggest that, even in industrial communities of high outdoor pollution concentrations, indoor activities--particularly cigarette smoking--may play a larger

  14. 32 CFR 701.120 - Processing requests that cite or imply PA, Freedom of Information (FOIA), or PA/FOIA.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., Freedom of Information (FOIA), or PA/FOIA. 701.120 Section 701.120 National Defense Department of Defense... Privacy Program § 701.120 Processing requests that cite or imply PA, Freedom of Information (FOIA), or PA/FOIA. Individuals do not always know what Act(s) to cite when requesting information. Nonetheless,...

  15. 32 CFR 701.120 - Processing requests that cite or imply PA, Freedom of Information (FOIA), or PA/FOIA.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., Freedom of Information (FOIA), or PA/FOIA. 701.120 Section 701.120 National Defense Department of Defense... Privacy Program § 701.120 Processing requests that cite or imply PA, Freedom of Information (FOIA), or PA/FOIA. Individuals do not always know what Act(s) to cite when requesting information. Nonetheless,...

  16. 32 CFR 701.120 - Processing requests that cite or imply PA, Freedom of Information (FOIA), or PA/FOIA.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., Freedom of Information (FOIA), or PA/FOIA. 701.120 Section 701.120 National Defense Department of Defense... Privacy Program § 701.120 Processing requests that cite or imply PA, Freedom of Information (FOIA), or PA/FOIA. Individuals do not always know what Act(s) to cite when requesting information. Nonetheless,...

  17. 32 CFR 701.120 - Processing requests that cite or imply PA, Freedom of Information (FOIA), or PA/FOIA.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., Freedom of Information (FOIA), or PA/FOIA. 701.120 Section 701.120 National Defense Department of Defense... Privacy Program § 701.120 Processing requests that cite or imply PA, Freedom of Information (FOIA), or PA/FOIA. Individuals do not always know what Act(s) to cite when requesting information. Nonetheless,...

  18. 32 CFR 701.120 - Processing requests that cite or imply PA, Freedom of Information (FOIA), or PA/FOIA.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., Freedom of Information (FOIA), or PA/FOIA. 701.120 Section 701.120 National Defense Department of Defense... Privacy Program § 701.120 Processing requests that cite or imply PA, Freedom of Information (FOIA), or PA/FOIA. Individuals do not always know what Act(s) to cite when requesting information. Nonetheless,...

  19. The Pseudomonas aeruginosa PA01 Gene Collection

    PubMed Central

    LaBaer, Joshua; Qiu, QingQing; Anumanthan, Anukanth; Mar, Wenhong; Zuo, Dongmei; Murthy, T.V.S.; Taycher, Helen; Halleck, Allison; Hainsworth, Eugenie; Lory, Stephen; Brizuela, Leonardo

    2004-01-01

    Pseudomonas aeruginosa, a common inhabitant of soil and water, is an opportunistic pathogen of growing clinical relevance. Its genome, one of the largest among bacteria [5570 open reading frames (ORFs)] approaches that of simple eukaryotes. We have constructed a comprehensive gene collection for this organism utilizing the annotated genome of P. aeruginosa PA01 and a highly automated and laboratory information management system (LIMS)-supported production line. All the individual ORFs have been successfully PCR-amplified and cloned into a recombination-based cloning system. We have isolated and archived four independent isolates of each individual ORF. Full sequence analysis of the first isolate for one-third of the ORFs in the collection has been completed. We used two sets of genes from this repository for high-throughput expression and purification of recombinant proteins in different systems. The purified proteins have been used to set up biochemical and immunological assays directed towards characterization of histidine kinases and identification of bacterial proteins involved in the immune response of cystic fibrosis patients. This gene repository provides a powerful tool for proteome- and genome-scale research of this organism, and the strategies adopted to generate this repository serve as a model for building clone sets for other bacteria. PMID:15489342

  20. Dengue in Florida (USA)

    PubMed Central

    Rey, Jorge R.

    2014-01-01

    Florida (USA), particularly the southern portion of the State, is in a precarious situation concerning arboviral diseases. The geographic location, climate, lifestyle, and the volume of travel and commerce are all conducive to arbovirus transmission. During the last decades, imported dengue cases have been regularly recorded in Florida, and the recent re-emergence of dengue as a major public health concern in the Americas has been accompanied by a steady increase in the number of imported cases. In 2009, there were 28 cases of locally transmitted dengue in Key West, and in 2010, 65 cases were reported. Local transmission was also reported in Martin County in 2013 (29 cases), and isolated locally transmitted cases were also reported from other counties in the last five years. Dengue control and prevention in the future will require close cooperation between mosquito control and public health agencies, citizens, community and government agencies, and medical professionals to reduce populations of the vectors and to condition citizens and visitors to take personal protection measures that minimize bites by infected mosquitoes. PMID:26462955

  1. Productivity improvement for longwall development

    SciTech Connect

    Whipkey, K.

    2005-08-01

    Industry survey reveals coal operators thoughts about the use of different techniques to keep development ahead of longwall production. Factors considered that can optimise productivity include mine design (the number of entries, size of pillars etc.), work schedules, preventative maintenance programs and good management. The article was adapted from a presentation to Longwall USA 2005, in June 2005 (Pittsburgh, PA, USA). 3 figs.

  2. View south of hydraulic hammer in boilermakers shop (probably the ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View south of hydraulic hammer in boilermakers shop (probably the oldest piece of equipment in the yard, originally powered by steam) nameplate: United Engineers and FDRY. Co. Pittsburgh, Pa, USA Davy Brothers LTD. Patents - Aug 1, 1905, Feb, 1901, Sept 8, 1908 - 10000 lbs. - Naval Base Philadelphia-Philadelphia Naval Shipyard, Structure Shop, League Island, Philadelphia, Philadelphia County, PA

  3. FrogwatchUSA

    USGS Publications Warehouse

    Droege, S.

    2002-01-01

    full text: Frogs and toads are perhaps the most approachable and available of all our wildlife. In many, if not most places, they are abundant. In wetter parts of the East, almost anyone outside on a warm rainy night in spring will hear their dream-like calls, bellows, trills and snores. Even in the deserts of the Southwest, a nocturnal trip after a summer monsoon will yield toads moving across the roads toward a cacophonous orgy of mating and calling in the roadside ditches and desert pools. Birds share with frogs and toads this same sense of presence in our daily lives. But the difference is that birds are like the attractive neighbor who just never gives you the time of day, while frogs are more like the troglodyte who appears regularly to chat, philosophize, and have a beer. Uninvited, frogs appear in our water gardens, toads are on our stoops in the morning, we catch them when we are kids, raise their babies in the aquarium, and feel sorry when we find we have run them over with the lawnmower. When concerns about declining populations of amphibians reached the mass media, the Secretaries' office became involved. In addition to using traditional research mechanisms to investigate the problem, the Secretary also wanted to involve the public directly. The combination of high public appeal and the relative ease with which frog calls can be learned made a large-scale monitoring program for frogs and toads possible. What emerged was a program called Frogwatch USA, modeled after a successful Canadian program with a similar name. A web site was created (www.frogwatch.org) that presented potential frogwatchers with directions and a way to register their site online as well as enter their data. Observers chose where to count frogs depending on what they felt was important. For some it was their backyard, others chose vulnerable wetlands in their neighborhoods, or spots on local refuges and parks. Initially funded at $8,000 a year and then after two years increased to

  4. Art, Science & Visual Literacy: Selected Readings from the Annual Conference of the International Visual Literacy Association (24th, Pittsburgh, Pennsylvania, September 30-October 4, 1992).

    ERIC Educational Resources Information Center

    Braden, Roberts A., Ed.; And Others

    Following an introductory paper on Pittsburgh and the arts, 57 conference papers are presented under the following four major categories: (1) "Imagery, Science and the Arts," including discovery in art and science, technology and art, visual design of newspapers, multimedia science education, science learning and interactive videodisc technology,…

  5. PROCEEDINGS: SYMPOSIUM ON IRON AND STEEL POLLUTION ABATEMENT TECHNOLOGY FOR 1982. HELD AT PITTSBURGH, PENNSYLVANIA, ON NOVEMBER 16-18, 1982

    EPA Science Inventory

    The proceedings document presentations at the Symposium on Iron and Steel Pollution Abatement Technology for 1982, the fourth in this series, held in Pittsburgh on November 16-18, 1982. It provided a forum for the exchange of information on technological problems related to multi...

  6. INTERNATIONAL CONFERENCE ON NEW FRONTIERS FOR HAZARDOUS WASTE MANAGEMENT. PROCEEDINGS OF A CONFERENCE HELD AT PITTSBURGH, PENNSYLVANIA ON SEPTEMBER 15-18, 1985

    EPA Science Inventory

    Proceedings of the International Conference on New Frontiers for Hazardous Waste Management held in Pittsburgh, Pennsylvania, September 15-18, 1985. Papers presented by Symposium speakers were in the areas of: (1) Geologic hazards and the siting of hazardous waste facilities; (2)...

  7. EVALUATION OF THE CMB AND PMF MODELS USING ORGANIC MOLECULAR MARKERS IN FINE PARTICULATE MATTER COLLECTED DURING THE PITTSBURGH AIR QUALITY STUDY

    EPA Science Inventory

    This research investigated different strategies for source apportionment of airborne fine particulate matter (PM2.5) collected as part of the Pittsburgh Air Quality Study. Two source receptor models were used, the EPA Chemical Mass Balance 8.2 (CMB) and EPA Positive Matrix Facto...

  8. Education for Highway Engineering and Highway Transport. Report of the Regional Conference Held at University of Pittsburgh, Friday, November 26, 1920. Bulletin, 1921, No. 47

    ERIC Educational Resources Information Center

    Johnson, Pyke; John, Walton C.

    1921-01-01

    This bulletin provides information on the proceedings of the regional conference on education for highway engineering and highway transport that was held at the University of Pittsburgh on November 26, 1920, under the direction of the highway and highway transport education committee. The purpose of this report is: (1) To stimulate greater…

  9. Evaluating the national air toxics assessment (NATA): Comparison of predicted and measured air toxics concentrations, risks, and sources in Pittsburgh, Pennsylvania

    NASA Astrophysics Data System (ADS)

    Logue, Jennifer M.; Small, Mitchell J.; Robinson, Allen L.

    2011-01-01

    The National Air Toxics Assessment (NATA) is an ongoing modeling effort by the Environmental Protection Agency to predict air toxics concentrations, sources, and risks at the census tract level throughout the continental United States. To evaluate NATA, archived data collected at seven sites in and around Pittsburgh, Pennsylvania were compared to 2002 NATA predictions. The sites represent 3 different source regimes (mobile dominated, industrial point source dominated, and background). The evaluation considered 49 air toxics (37 gas-phase organics, 10 metals, coke oven emissions and diesel particulate matter); NATA's performance was judged based on model-measurement comparisons of concentrations, health risks, and source contributions. On a concentration basis, NATA performance varied widely ranging from excellent for carbon tetrachloride to differences of more than a factor of 100 for low concentration chlorinated compounds. However, predicted concentrations were generally within a factor of 2 of measured values for air toxics that were estimated to be the primary cancer risk drivers; therefore NATA provided reasonable estimates of the additive cancer risks and risk ranking of air toxics. NATA performs better on average in Pittsburgh than nationwide. Comparison of source apportionment results indicates that NATA consistently underestimated concentrations of compounds emitted by large point sources as well as concentrations of chlorinated compounds, but overestimated the risks from mobile sources in Pittsburgh. Therefore, in Pittsburgh, NATA sufficiently prioritizes air toxics that drive potential cancer risks, but does not identify the sources of these priority air toxics.

  10. “Food is directed to the area”: African Americans’ perceptions of the neighborhood nutrition environment in Pittsburgh

    PubMed Central

    Quinn, Sandra C.; Kriska, Andrea M.; Thomas, Stephen B.

    2011-01-01

    Studies have shown racial disparities in neighborhood access to healthy food in the United States. We used a mixed methods approach employing geographic information systems, focus groups, and a survey to examine African Americans’ perceptions of the neighborhood nutrition environment in Pittsburgh. We found that African Americans perceive that supermarkets serving their community offer produce and meats of poorer quality than branches of the same supermarket serving White neighborhoods (p<0.001). Unofficial taxis or jitneys, on which many African Americans are reliant, provide access from only certain stores; people are therefore forced to patronize these stores even though they are perceived to be of poorer quality. Community-generated ideas to tackle the situation include ongoing monitoring of supermarkets serving the Black community. We conclude that stores should make every effort to be responsive to the perceptions and needs of their clients and provide an environment that enables healthy eating. PMID:21169050

  11. Genome Sequence of Pseudomonas chlororaphis Strain PA23

    PubMed Central

    Loewen, Peter C.; Villenueva, Jacylyn; Fernando, W. G. Dilantha

    2014-01-01

    Pseudomonas chlororaphis strain PA23 is a plant-beneficial bacterium that is able to suppress disease caused by the fungal pathogen Sclerotinia sclerotiorum through a process known as biological control. Here we present a 7.1-Mb assembly of the PA23 genome. PMID:25035328

  12. 32 CFR 701.109 - Privacy Act (PA) appeals.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 5 2014-07-01 2014-07-01 false Privacy Act (PA) appeals. 701.109 Section 701.109 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY UNITED STATES NAVY... OF THE NAVY DOCUMENTS AFFECTING THE PUBLIC DON Privacy Program § 701.109 Privacy Act (PA) appeals....

  13. 32 CFR 701.109 - Privacy Act (PA) appeals.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 5 2012-07-01 2012-07-01 false Privacy Act (PA) appeals. 701.109 Section 701.109 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY UNITED STATES NAVY... OF THE NAVY DOCUMENTS AFFECTING THE PUBLIC DON Privacy Program § 701.109 Privacy Act (PA) appeals....

  14. 32 CFR 701.109 - Privacy Act (PA) appeals.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 5 2013-07-01 2013-07-01 false Privacy Act (PA) appeals. 701.109 Section 701.109 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY UNITED STATES NAVY... OF THE NAVY DOCUMENTS AFFECTING THE PUBLIC DON Privacy Program § 701.109 Privacy Act (PA) appeals....

  15. 32 CFR 701.109 - Privacy Act (PA) appeals.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 5 2011-07-01 2011-07-01 false Privacy Act (PA) appeals. 701.109 Section 701.109 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY UNITED STATES NAVY... OF THE NAVY DOCUMENTS AFFECTING THE PUBLIC DON Privacy Program § 701.109 Privacy Act (PA) appeals....

  16. Atomic structure of anthrax PA pore elucidates toxin translocation

    PubMed Central

    Jiang, Jiansen; Pentelute, Bradley L.; Collier, R. John; Zhou, Z. Hong

    2015-01-01

    Summary Anthrax toxin, comprising protective antigen (PA), lethal factor (LF) and edema factor (EF), is the major virulence factor of Bacillus anthracis, an agent that causes high mortality in human and animals. PA forms oligomeric prepores that undergo conversion to membrane-spanning pores by endosomal acidification, and these pores translocate the enzymes LF and EF into the cytosol of target cells1. PA is not only a vaccine component and therapeutic target for anthrax infections but also an excellent model system for understanding the mechanism of protein translocation. Based on biochemical and electrophysiological results, researchers have proposed that a Φ-clamp composed of Phe427 residues of PA catalyzes protein translocation via a charge-state dependent Brownian ratchet2–9. Although atomic structures of PA prepores are available10–14, how PA senses low pH, converts to active pore and translocates LF and EF are not well defined without an atomic model of the PA pore. Here, by cryo electron microscopy (cryoEM) with direct electron counting, we have determined the PA pore structure at 2.9-Å resolution. The structure reveals the long-sought-after catalytic Φ-clamp and the membrane-spanning translocation channel, and supports the Brownian ratchet model for protein translocation. Comparisons of four structures reveal conformational changes in prepore to pore conversion that support a multi-step mechanism by which low-pH is sensed and the membrane-spanning channel is formed. PMID:25778700

  17. Bed plate for rail bending machine, Johnson Company, Johnstown, Pa. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Bed plate for rail bending machine, Johnson Company, Johnstown, Pa. Scale 3 inches - 1 ft, Jan 30th 1893, drawing number 14929. (Photograph of drawing held at the Johnstown Corporation General Office,Johnstown, Pennsylvania) - Johnson Steel Street Rail Company, 525 Central Avenue, Johnstown, Cambria County, PA

  18. General plan, bending machinge, Johnson Company, Johnstown, Pa. Scale 3 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    General plan, bending machinge, Johnson Company, Johnstown, Pa. Scale 3 inches - 1 ft, March 13th 1893, drawing number 15384 (photograph of drawing of rail bending machine held at the Johnstown Corporation General Office, Johnstown, Pennsylvania) - Johnson Steel Street Rail Company, 525 Central Avenue, Johnstown, Cambria County, PA

  19. 78 FR 26243 - Amendment of Class E Airspace; Easton, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-06

    ... Federal Register a notice of proposed rulemaking (NPRM) to amend Class E airspace at Easton, PA (78 FR..., 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The incorporation... Federal Aviation Administration 14 CFR Part 71 Amendment of Class E Airspace; Easton, PA AGENCY:...

  20. 77 FR 45240 - Establishment of Class E Airspace; Quakertown, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-31

    ... Airspace at Quakertown, PA, to accommodate the new Area Navigation (RNAV) Global Positioning System (GPS... Quakertown, PA (77 FR 30438) Docket No. FAA-2012-0386. Interested parties were invited to participate in this... Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a Regulatory...

  1. 77 FR 16669 - Establishment of Class E Airspace; Bellefonte, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-22

    ... airspace at Bellefonte, PA, to accommodate new Area Navigation (RNAV) Global Positioning System (GPS... surface at Bellefonte, PA (76 FR 79564). Interested parties were invited to participate in this rulemaking... Policies and Procedures (44 FR 11034; February 26, 1979); and (3) ] does not warrant preparation of...

  2. 76 FR 64234 - Establishment of Class E Airspace; Palmyra, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-18

    ... airspace at Palmyra, PA, to accommodate new Area Navigation (RNAV) Global Positioning System (GPS) Standard... (NPRM) to amend Class E airspace 700 feet above the surface, at Palmyra, PA (76 FR 49390). Interested... Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a Regulatory...

  3. Sex Steroid Hormone Profiles are Related to Sleep Measures from Polysomnography and the Pittsburgh Sleep Quality Index

    PubMed Central

    Sowers, Mary Fran; Zheng, Huiyong; Kravitz, Howard M.; Matthews, Karen; Bromberger, Joyce T.; Gold, Ellen B.; Owens, Jane; Consens, Flavia; Hall, Martica

    2008-01-01

    Study Objectives: To relate reproductive hormones (and the preceding 7-year rates of their change) to objectively and subjectively assessed sleep measures, independent of age, vasomotor symptom frequency, depressive symptoms, and body size. Design: A cross-sectional sleep substudy nested in the Study of Women's Health Across the Nation (SWAN), a longitudinal study of the menopausal transition. Setting: Community-based. Participants: 365 Caucasian, African American, and Chinese women. Measurements and Results: Sleep duration, continuity, and architecture were measured during two nights of in-home polysomnography (PSG) studies. Participants completed the Pittsburgh Sleep Quality Index (PSQI) for sleep quality, sleep diaries for medication, vasomotor symptoms, lifestyle information and questionnaires for depressive symptoms. Blood collected annually in the years prior to sleep study was assayed for follicle stimulating hormone (FSH), estradiol (E2), and total testosterone (T). More rapid rate of FSH change was significantly associated with higher delta sleep percent, longer total sleep time (TST), but less favorable self-reported sleep quality (PSQI). Baseline E2 was modestly and negatively associated with sleep quality. Women in the lowest total testosterone quartile at baseline had more wake time after sleep onset (WASO) than women in the highest quartile. Lower E2/T ratio, an index reflecting the increasing androgenic environment with the menopause transition, was associated with less WASO. Conclusions: More rapid rate of FSH change was associated with longer sleep duration but poor sleep quality. Women with higher T or who were closer to the completion of the transition process (as indexed by a lower E2/T) had less sleep discontinuity (less WASO). Citation: Sowers MF; Zheng H; Kravitz HM; Matthews K; Bromberger JT; Gold EB; Owens J; Consens F; Hall M. Sex steroid hormone profiles are related to sleep measures From polysomnography and the pittsburgh sleep quality

  4. Observations of 231Pa/ 235U disequilibrium in volcanic rocks

    NASA Astrophysics Data System (ADS)

    Pickett, David A.; Murrell, Michael T.

    1997-04-01

    We present here the first survey of ( 231Pa/ 235U) ratios in volcanic rocks; such measurements are made possible by new mass spectrometric techniques. The data place new constraints on the timing and extent of magma source and evolutionary processes, particularly due to the sensitivity of the 231Pa- 235U pair and its intermediate time scale ( 231Pat 1/2 = 33 ky). ( 231Pa/ 235U) is found to vary widely, from 0.2 in carbonatites to 1.1-2.9 in basalts and 0.9-2.2 in arcs. Substantial Pa enrichment is nearly ubiquitous, suggestive of the relative incompatibility of Pa, qualitatively consistent with available partitioning data. The level of 231Pa- 235U disequilibrium typically far exceeds that of 230Th- 238U and is comparable to 226Ra- 230Th. The high ( 231Pa/ 235U) ratios in MORB and other basalts reflect a large degree of discrimination between two incompatible elements, posing challenges for modelling of melt generation and migration. Fundamental differences in ( 231Pa/ 235U) among different basaltic environments are likely related to contrasts in melting zone conditions (e.g., melting rate). Strong ( 231Pa/ 235U) disequilibria in continental basalts, for which ( 230Th/ 238U) disequilibria are small or absent, demonstrate that Pa-U fractionation is possible in both garnet and spinel mantle stability fields. In arcs, correlation of ( 231Pa/ 235U) and ( 230Th/ 238U) is consistent with U enrichment via slab-derived fluids, a process which is additional to the still dominant Pa enrichment. An important new constraint is provided by the observation that the near-equilibrium ( 230Th/ 238U) common to arcs and continental basalts is not typically accompanied by near-equilibrium ( 231Pa/ 235U), arguing against the influence of long magma history, crustal material, or equilibrium mantle sources in affecting decay-series ratios. Small sample sets from two silicic centers illustrate: (1) recent, rapid U enrichment in the magma chamber (El Chichón); and (2) the failure of

  5. Elucidating Protactinium Hydrolysis: The Relative Stabilities of PaO2(H2O)(+) and PaO(OH)2(+).

    PubMed

    Dau, Phuong D; Wilson, Richard E; Gibson, John K

    2015-08-01

    It is demonstrated that the gas-phase oxo-exchange of PaO2(+) with water is substantially faster than that of UO2(+), indicating that the Pa-O bonds are more susceptible to activation and formation of the bis-hydroxide intermediate, PaO(OH)2(+). To elucidate the nature of the water adduct of PaO2(+), hydration of PaO2(+) and UO2(+), as well as collision induced dissociation (CID) and ligand-exchange of the water adducts of PaO2(+) and UO2(+), was studied. The results indicate that, in contrast to UO2(H2O)(+), the protactinium oxo bis-hydroxide isomer, PaO(OH)2(+), is produced as a gas-phase species close in energy to the hydrate isomer, PaO2(H2O)(+). CID behavior similar to that of Th(OH)3(+) supports the assignment as PaO(OH)2(+). The gas-phase results are consistent with the spontaneous hydrolysis of PaO2(+) in aqueous solution, this in contrast to later AnO2(+) (An = U, Np, Pu), which forms stable hydrates in both solution and gas phase. In view of the known propensity for Th(IV) to hydrolyze, and previous gas-phase studies of other AnO2(+), it is concluded that the stabilities of oxo-hydroxides relative to oxide hydrates decreases in the order: Th(IV) > Pa(V) > U(V) > Np(V) > Pu(V). This trend suggests increasing covalency and decreasing ionicity of An-O bonds upon proceeding across the actinide series. PMID:26203499

  6. Historical carbon footprinting and implications for sustainability planning: a case study of the Pittsburgh region.

    PubMed

    Hoesly, Rachel; Blackhurst, Mike; Matthews, H Scott; Miller, Jeffrey F; Maples, Amy; Pettit, Matthew; Izard, Catherine; Fischbeck, Paul

    2012-04-17

    This study estimates fossil-based CO(2) emissions and energy use from 1900-2000 for Allegheny County, PA. Total energy use and emissions increased from 1900 to 1970, reflecting the significant industrial, economic, and population growth that occurred in Allegheny County. From 1970 to 2000, Allegheny County experienced a 30% decrease in total emissions and energy use from peak values, primarily because of a decline in industrial activity (40% decrease in value added) and the loss of a quarter of its population. Despite these dramatic economic and demographic transitions, per capita emissions remained stable from 1970 to 2000, buoyed by relatively stable or slightly increasing emissions in the commercial and transportation sectors. Allegheny County's history suggests the scale of change needed to achieve local emissions reductions may be significant; given years of major technological, economic, and demographic changes, per capita emissions in 1940 were nearly the same in 2000. Most local governments are planning emissions reductions rates that exceed 1% per year, which deviate significantly from historical trends. Our results suggest additional resources and improved planning paradigms are likely necessary to achieve significant emissions reductions, especially for areas where emissions are still increasing. PMID:22458634

  7. PA014-- Deception and Doubt --Strategies for Undermining and Supporting Global Climate Science--PA014

    NASA Astrophysics Data System (ADS)

    Nelson, C.

    2012-12-01

    DECEPTION AND DOUBT--STRATEGIES FOR UNDERMINING AND SUPPORTING GLOBAL CLIMATE SCIENCE--PA014 The fundamental strategy for undermining confidence in the now substantial scientific consensus about global warming is to sow doubt about the degree of consensus. Rather than mount an obvious anti-science stance, commercial interests seek to champion science, arguing for better science, more complete and definitive science. This strategy has a sixty-year history, beginning with the tobacco industry in the 1950s and proceeding through the chemical, energy, paint, and other industries. Thousands of faculty members have quietly sold themselves as public spokespersons or confidential consultants to industry in the service of this strategy. A multipart program--involving educating people about this history and exposing faculty collaboration--may help free climate science from those who aim to distort its conclusions.

  8. Biogeography in 231Pa/230Th ratios and a balanced 231Pa budget for the Pacific Ocean

    NASA Astrophysics Data System (ADS)

    Hayes, Christopher T.; Anderson, Robert F.; Fleisher, Martin Q.; Serno, Sascha; Winckler, Gisela; Gersonde, Rainer

    2014-04-01

    The ratio of unsupported protactinium-231 to thorium-230 in marine sediments, (Pa/Th)xs, is potentially sensitive to several processes of oceanographic and climatological interest: deep ocean circulation, marine biological productivity (as it relates to total particle flux) and particle composition (specifically, biogenic opal and authigenic Mn). In order to attribute variations in (Pa/Th)xs observed in sediment records to changes in specific processes through time, a better understanding of the chemical cycling of these elements in the modern ocean is necessary. To this end, a survey was undertaken of (Pa/Th)xs in surface sediments from the subarctic Pacific (SO202-INOPEX expedition) in combination with a Pacific-wide compilation of published data. Throughout the Pacific, (Pa/Th)xs is robustly correlated with the opal content of sediments. In the North and equatorial Pacific, simultaneous positive correlations with productivity indicators suggest that boundary scavenging and opal scavenging combine to enhance the removal of Pa in the eastern equatorial Pacific and subarctic Pacific. Deep ocean water mass ageing (>3.5 km) associated with the Pacific overturning appears to play a secondary role in determining the basin scale distribution of (Pa/Th)xs. A basin-wide extrapolation of Pa removal is performed which suggests that the Pacific Pa budget is nearly in balance. We hypothesize that through time (Pa/Th)xs distributions in the Pacific could define the evolving boundaries of contrasting biogeographic provinces in the North Pacific, while the influence of hydrothermal scavenging of Pa potentially confounds this approach in the South Pacific.

  9. Public transit generates new physical activity: Evidence from individual GPS and accelerometer data before and after light rail construction in a neighborhood of Salt Lake City, Utah, USA.

    PubMed

    Miller, Harvey J; Tribby, Calvin P; Brown, Barbara B; Smith, Ken R; Werner, Carol M; Wolf, Jean; Wilson, Laura; Oliveira, Marcelo G Simas

    2015-11-01

    Poor health outcomes from insufficient physical activity (PA) are a persistent public health issue. Public transit is often promoted for positive influence on PA. Although there is cross-sectional evidence that transit users have higher PA levels, this may be coincidental or shifted from activities such as recreational walking. We use a quasi-experimental design to test if light rail transit (LRT) generated new PA in a neighborhood of Salt Lake City, Utah, USA. Participants (n=536) wore Global Positioning System (GPS) receivers and accelerometers before (2012) and after (2013) LRT construction. We test within-person differences in individuals' PA time based on changes in transit usage pre- versus post-intervention. We map transit-related PA to detect spatial clustering of PA around the new transit stops. We analyze within-person differences in PA time based on daily transit use and estimate the effect of daily transit use on PA time controlling for socio-demographic variables. Results suggest that transit use directly generates new PA that is not shifted from other PA. This supports the public health benefits from new high quality public transit such as LRT. PMID:26340643

  10. Microfluidic manufacture of rt-PA-loaded echogenic liposomes

    PubMed Central

    Kandadai, Madhuvanthi A.; Mukherjee, Prithviraj; Shekhar, Himanshu; Shaw, George J.; Papautsky, Ian; Holland, Christy K.

    2016-01-01

    Echogenic liposomes (ELIP), loaded with recombinant tissue-type plasminogen activator (rt-PA) and microbubbles that act as cavitation nuclei, are under development for ultrasound-mediated thrombolysis. Conventional manufacturing techniques produce a polydisperse rt-PA-loaded ELIP population with only a small percentage of particles containing microbubbles. Further, a polydisperse population of rt-PA-loaded ELIP has a broadband frequency response with complex bubble dynamics when exposed to pulsed ultrasound. In this work, a microfluidic flow-focusing device was used to generate monodisperse rt-PA-loaded ELIP (µtELIP) loaded with a perfluorocarbon gas. The rt-PA associated with the µtELIP was encapsulated within the lipid shell as well as intercalated within the lipid shell. The µtELIP had a mean diameter of 5 µm, a resonance frequency of 2.2 MHz, and were found to be stable for at least 30 min in 0.5%bovine serum albumin. Additionally, 35 % of µtELIP particles were estimated to contain microbubbles, an order of magnitude higher than that reported previously for batch-produced rt-PA-loaded ELIP. These findings emphasize the advantages offered by microfluidic techniques for improving the encapsulation efficiency of both rt-PA and perflurocarbon microbubbles within echogenic liposomes. PMID:27206512

  11. Microfluidic manufacture of rt-PA -loaded echogenic liposomes.

    PubMed

    Kandadai, Madhuvanthi A; Mukherjee, Prithviraj; Shekhar, Himanshu; Shaw, George J; Papautsky, Ian; Holland, Christy K

    2016-06-01

    Echogenic liposomes (ELIP), loaded with recombinant tissue-type plasminogen activator (rt-PA) and microbubbles that act as cavitation nuclei, are under development for ultrasound-mediated thrombolysis. Conventional manufacturing techniques produce a polydisperse rt-PA-loaded ELIP population with only a small percentage of particles containing microbubbles. Further, a polydisperse population of rt-PA-loaded ELIP has a broadband frequency response with complex bubble dynamics when exposed to pulsed ultrasound. In this work, a microfluidic flow-focusing device was used to generate monodisperse rt-PA-loaded ELIP (μtELIP) loaded with a perfluorocarbon gas. The rt-PA associated with the μtELIP was encapsulated within the lipid shell as well as intercalated within the lipid shell. The μtELIP had a mean diameter of 5 μm, a resonance frequency of 2.2 MHz, and were found to be stable for at least 30 min in 0.5 % bovine serum albumin. Additionally, 35 % of μtELIP particles were estimated to contain microbubbles, an order of magnitude higher than that reported previously for batch-produced rt-PA-loaded ELIP. These findings emphasize the advantages offered by microfluidic techniques for improving the encapsulation efficiency of both rt-PA and perflurocarbon microbubbles within echogenic liposomes. PMID:27206512

  12. tPA-S481A prevents neurotoxicity of endogenous tPA in traumatic brain injury.

    PubMed

    Armstead, William M; Riley, John; Yarovoi, Serge; Cines, Douglas B; Smith, Douglas H; Higazi, Abd Al-Roof

    2012-06-10

    Traumatic brain injury (TBI) is associated with loss of autoregulation due to impaired responsiveness to cerebrovascular dilator stimuli, which leads to cerebral hypoperfusion and neuronal impairment or death. Upregulation of tissue plasminogen activator (tPA) post-TBI exacerbates loss of cerebral autoregulation and NMDA-receptor-mediated impairment of cerebral hemodynamics, and enhances excitotoxic neuronal death. However, the relationship between NMDA-receptor activation, loss of autoregulation, and neurological dysfunction is unclear. Here, we evaluated the potential therapeutic efficacy of a catalytically inactive tPA variant, tPA S481A, that acts by competing with wild-type tPA for binding, cleavage, and activation of NMDA receptors. Lateral fluid percussion brain injury was produced in anesthetized piglets. Pial artery reactivity was measured via a closed cranial window, and cerebrospinal fluid (CSF) extracellular signal-regulated kinase (ERK) mitogen-activated protein kinase (MAPK) was quantified by enzyme-linked immunosorbent assay (ELISA). tPA-S481A prevented impairment of cerebral autoregulation and reduced histopathologic changes after TBI by inhibiting upregulation of the ERK isoform of MAPK. Treatment with this tPA variant provides a novel approach for limiting neuronal toxicity caused by untoward NMDA-receptor activation mediated by increased tPA and glutamate following TBI. PMID:22435890

  13. 15. Photocopy of original drawing, Bethlehem Steel Company (Bethlehem, PA) ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    15. Photocopy of original drawing, Bethlehem Steel Company (Bethlehem, PA) 1928 (Source: Vermont Agency of Transportation) DETAILS OF PORTALS AND TOP LATERALS - Jeffersonville Bridge, Spanning Lamoille River on Vermont Route 15, Cambridge, Lamoille County, VT

  14. 78 FR 7848 - Pennsylvania Disaster Number PA-00057

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-04

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster Number PA-00057 AGENCY: U.S. Small Business Administration. ACTION.... ADDRESSES: Submit completed loan applications to: U.S. Small Business Administration, Processing...

  15. 32 CFR 701.124 - PA self assessments/inspections.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... SECNAVINST 5210.8D). These reports shall be made available to PA program officials and to CNO (DNS-36)/CMC... until the next self-assessment is completed. Make these reports available, upon request, to CNO...

  16. 32 CFR 701.124 - PA self assessments/inspections.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... SECNAVINST 5210.8D). These reports shall be made available to PA program officials and to CNO (DNS-36)/CMC... until the next self-assessment is completed. Make these reports available, upon request, to CNO...

  17. Orion PA-1 Flight Test Crew Module Back at Dryden

    NASA Video Gallery

    The boilerplate Orion crew module and separation ring that was flown in the Launch Abort system PA-1 flight test at White Sands Missile Range, N.M., May 6 were airlifted back to NASA Dryden at Edwa...

  18. 76 FR 70528 - Pennsylvania Disaster Number PA-00044

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-14

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster Number PA-00044 AGENCY: U.S. Small Business Administration. ACTION... unchanged. (Catalog of Federal Domestic Assistance Numbers 59002 and 59008) James E. Rivera,...

  19. 76 FR 70527 - Pennsylvania Disaster Number PA-00042

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-14

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster Number PA-00042 AGENCY: U.S. Small Business Administration. ACTION... unchanged. (Catalog of Federal Domestic Assistance Numbers 59002 and 59008) James E. Rivera...

  20. 76 FR 61130 - Pennsylvania Disaster Number PA-00044

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-03

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster Number PA-00044 AGENCY: U.S. Small Business Administration. ACTION... remains unchanged. (Catalog of Federal Domestic Assistance Numbers 59002 and 59008) James E....

  1. 76 FR 68803 - Pennsylvania Disaster Number PA-00044

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-07

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster Number PA-00044 AGENCY: U.S. Small Business Administration. ACTION... in the original declaration remains unchanged. (Catalog of Federal Domestic Assistance Numbers...

  2. 76 FR 72994 - Pennsylvania Disaster Number PA-00045

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-28

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster Number PA-00045 AGENCY: U.S. Small Business Administration. ACTION... Federal Domestic Assistance Numbers 59002 and 59008) James E. Rivera, Associate Administrator for...

  3. ENVIRONMENTAL TECHNOLOGY VERIFICATION REPORT PHYSICAL REMOVAL OF CRYPTOSPORIDIUM OOCYSTS AND GIARDIA CYSTS IN DRINKING WATER PALL CORPORATION WPM-1 MICROFILTRATION SYSTEM AT PITTSBURGH, PA - NSF 00/09/EPADW395

    EPA Science Inventory

    Verification testing of the Pall Corporation WPM-1 Microfiltration Pilot System was conducted from February 3 to March 5, 1999. The Pall WPM-1 membrane is a hollow fiber type microfiltration membrane made of polyvinylidenefluoride (PVDF). It has a 0.1 micrometer ( m) nominal por...

  4. ETV REPORT - PHYSICAL REMOVAL OF CRYPTOSPORIDIUM OOCYSTS AND GIARDIA CYSTS IN DRINKING WATER AQUASOURCE NORTH AMERICA ULTRAFILTRATION SYSTEM A35 AT PITTSBURGH, PA. - NSF00/07/EPADW395

    EPA Science Inventory

    Verification testing of the Aquasource Ultrafiltration Treatment System Model A35 was conducted from 12/1 - 12/31/98. The treatment system underwent microbial challenge testing on 1/22/99 and demonstrated a 5.5 log10 removal of Giardia cysts and a 6.5 log10 removal of Cryptospori...

  5. Avian metapneumovirus in the USA

    Technology Transfer Automated Retrieval System (TEKTRAN)

    In the United States of America (USA), avian metapneumovirus (aMPV) causes an upper respiratory tract infection in turkeys; no outbreaks have been reported in commercial chicken flocks. Typical clinical signs of the disease in turkey poults include coughing, sneezing, nasal discharge, tracheal rale...

  6. Dyslexia Laws in the USA

    ERIC Educational Resources Information Center

    Youman, Martha; Mather, Nancy

    2013-01-01

    Throughout the various states of the USA, the appropriate identification of dyslexia and the timely provision of interventions are characterized by variability and inconsistency. Several states have recognized the existence of this disorder and the well-established need for services. These states have taken proactive steps to implement laws and…

  7. Detection of anthrax protective antigen (PA) using europium labeled anti-PA monoclonal antibody and time-resolved fluorescence.

    PubMed

    Stoddard, Robyn A; Quinn, Conrad P; Schiffer, Jarad M; Boyer, Anne E; Goldstein, Jason; Bagarozzi, Dennis A; Soroka, Stephen D; Dauphin, Leslie A; Hoffmaster, Alex R

    2014-06-01

    Inhalation anthrax is a rare but acute infectious disease following adsorption of Bacillus anthracis spores through the lungs. The disease has a high fatality rate if untreated, but early and correct diagnosis has a significant impact on case patient recovery. The early symptoms of inhalation anthrax are, however, non-specific and current anthrax diagnostics are primarily dependent upon culture and confirmatory real-time PCR. Consequently, there may be a significant delay in diagnosis and targeted treatment. Rapid, culture-independent diagnostic tests are therefore needed, particularly in the context of a large scale emergency response. The aim of this study was to evaluate the ability of monoclonal antibodies to detect anthrax toxin proteins that are secreted early in the course of B. anthracis infection using a time-resolved fluorescence (TRF) immunoassay. We selected monoclonal antibodies that could detect protective antigen (PA), as PA83 and also PA63 and LF in the lethal toxin complex. The assay reliable detection limit (RDL) was 6.63×10(-6)μM (0.551ng/ml) for PA83 and 2.51×10(-5)μM (1.58ng/ml) for PA63. Despite variable precision and accuracy of the assay, PA was detected in 9 out of 10 sera samples from anthrax confirmed case patients with cutaneous (n=7), inhalation (n=2), and gastrointestinal (n=1) disease. Anthrax Immune Globulin (AIG), which has been used in treatment of clinical anthrax, interfered with detection of PA. This study demonstrates a culture-independent method of diagnosing anthrax through the use of monoclonal antibodies to detect PA and LF in the lethal toxin complex. PMID:24857756

  8. 75 FR 10822 - FCI USA, LLC Including On-Site Leased Workers From Manpower, Inc.; Mount Union, PA; Amended...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-09

    ..., 2010. The notice was published in the Federal Register on March 7, 2008 (73 FR 12466). In order to... communications devices, personal computers, and auto dashboards. The review shows that on February 21, 2008,...

  9. 75 FR 10505 - FCI USA, LLC, Including On-Site Leased Workers From Manpower, Inc., Mount Union, PA; Amended...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-08

    ..., 2010. The notice was published in the Federal Register on March 7, 2008 (73 FR 12466). In order to... communications devices, personal computers, and auto dashboards. The review shows that on February 21, 2008,...

  10. A study of parabens and bisphenol A in surface water and fish brain tissue from the Greater Pittsburgh Area.

    PubMed

    Renz, Lara; Volz, Conrad; Michanowicz, Drew; Ferrar, Kyle; Christian, Charles; Lenzner, Diana; El-Hefnawy, Talal

    2013-05-01

    Pollution from xenoestrogens has been discovered in the aquatic environment of the Greater Pittsburgh Area and is suspected to be caused by the failing sewer system. Personal care products and plasticizers have the potential to enter the water supply though treated and untreated sewage. Many of these compounds are suspected xenoestrogens. Paraben detection in surface waters was as follows: methyl paraben ranged between 2.2 to 17.3 ppt; ethyl paraben was not detectable; propyl paraben was detected at 9.2 and 12.0 ppt; butyl paraben was detected at 0.2 ppt. BPA was detected between 0.6 and 15.4 ppt. Estrogenic potential of extracts from fish brain tissue was tested via Bromodeoxyuridine MCF-7 analysis and paired with HPLC-MS to investigate the presence of xenoestrogens. All samples were non-detectable for parabens. BPA was detected in 44 of the 58 samples, with a range from non-detectable to 120 pg/g. BCFs were calculated. Results were statistically significant for location of capture (p < 0.05) and correlation existed between estrogenicity and BPA. PMID:23479059

  11. Countercurrent washing of Pittsburgh No. 8 coal after leaching with molten mixtures of sodium and potassium hydroxides

    SciTech Connect

    Chriswell, C.D.; Shah, N.D.; Markuszewski, R. )

    1991-01-01

    Molten caustic leaching is an advanced chemical coal-cleaning process which results in the removal of over 90% of the sulfur and ash from coal. One of the steps in this process is the water washing of caustic-leached coals to remove unreacted caustic and impurities released by reactions with the molten caustic. A countercurrent procedure, designed for efficient washing with minimal water consumption, has been evaluated in the present work. A Pittsburgh No. 8 coal was leached with a one-to-one mixture of molten sodium and potassium hydroxides, and the resulting coal-caustic cake was washed using this countercurrent procedure. The countercurrent washing did result in recovery of caustic at predicted concentrations, and a relatively ash-free and sulfur-free coal was the final product. However, significant problems occurred during the countercurrent washing, all of which could be linked with the formation of a massive precipitate of carbonates from the alkaline process streams. The mass of the precipitate retained fluids and thus led to far lower than predicted recoveries of caustic solutions. the precipitate also caused a significant decrease in filtration rates.

  12. 231Pa systematics in postglacial volcanic rocks from Iceland

    NASA Astrophysics Data System (ADS)

    Turner, Simon; Kokfelt, Thomas; Hoernle, Kaj; Lundstrom, Craig; Hauff, Folkmar

    2016-07-01

    Several recent studies have highlighted the potential of combined 238U-230Th and 235U-231Pa systematics to constrain upwelling rates and the role of recycled mafic lithologies in mantle plume-derived basalts. Accordingly, we present measurements of the 231Pa concentrations from 26 mafic volcanic rocks from Iceland, including off-axis basalts from the Snaefellsnes Peninsula, to complement previously published 238U-230Th-226Ra data. 231Pa concentrations vary from 27 to 624 fg/g and (231Pa/235U) ratios from 1.12 to 2.11 with the exception of one anomalous sample from the Southeast Rift which has a 231Pa deficit with (231Pa/235U) = 0.86. An important new result is that basalts from the Southeast Rift and the Snaefellsnes Peninsula define a trend at relatively low (231Pa/235U) for a given (230Th/238U) ratio. Many of the remaining samples fall in or around the global field for ocean island basalts but those from the Mid-Iceland Belt and the Southwest Rift/Reykjanes Peninsula extend to higher (231Pa/235U) ratios at a given (230Th/238U), similar to mid-ocean ridge basalts. In principle, these lavas could result from melting of peridotite at lower pressures. However, there is no reason to suspect that the Mid-Iceland Belt and the Southwest Rift lavas reflect shallower melting than elsewhere in Iceland. In our preferred model, these lavas reflect melting of garnet peridotite whereas those from the Southeast Rift and the Snaefellsnes Peninsula contain a significant contribution (up to 20%) of melt from garnet pyroxenite. This is consistent with incompatible trace element and radiogenic isotope evidence for recycled oceanic crust in these lavas. There is increasing agreement that the displacement of ocean island basalts to lower (231Pa/235U) ratios at a given (230Th/238U), compared to mid-ocean ridge basalts, reflects the role of recycled mafic lithologies such as garnet pyroxenite as well as higher average pressures of melting. It now seems likely that this interpretation may

  13. Morphological studies on block copolymer modified PA 6 blends

    SciTech Connect

    Poindl, M. E-mail: christian.bonten@ikt.uni-stuttgart.de; Bonten, C. E-mail: christian.bonten@ikt.uni-stuttgart.de

    2014-05-15

    Recent studies show that compounding polyamide 6 (PA 6) with a PA 6 polyether block copolymers made by reaction injection molding (RIM) or continuous anionic polymerization in a reactive extrusion process (REX) result in blends with high impact strength and high stiffness compared to conventional rubber blends. In this paper, different high impact PA 6 blends were prepared using a twin screw extruder. The different impact modifiers were an ethylene propylene copolymer, a PA PA 6 polyether block copolymer made by reaction injection molding and one made by reactive extrusion. To ensure good particle matrix bonding, the ethylene propylene copolymer was grafted with maleic anhydride (EPR-g-MA). Due to the molecular structure of the two block copolymers, a coupling agent was not necessary. The block copolymers are semi-crystalline and partially cross-linked in contrast to commonly used amorphous rubbers which are usually uncured. The combination of different analysis methods like atomic force microscopy (AFM), transmission electron microscopy (TEM) and scanning electron microscopy (SEM) gave a detailed view in the structure of the blends. Due to the partial cross-linking, the particles of the block copolymers in the blends are not spherical like the ones of ethylene propylene copolymer. The differences in molecular structure, miscibility and grafting of the impact modifiers result in different mechanical properties and different blend morphologies.

  14. Morphological studies on block copolymer modified PA 6 blends

    NASA Astrophysics Data System (ADS)

    Poindl, M.; Bonten, C.

    2014-05-01

    Recent studies show that compounding polyamide 6 (PA 6) with a PA 6 polyether block copolymers made by reaction injection molding (RIM) or continuous anionic polymerization in a reactive extrusion process (REX) result in blends with high impact strength and high stiffness compared to conventional rubber blends. In this paper, different high impact PA 6 blends were prepared using a twin screw extruder. The different impact modifiers were an ethylene propylene copolymer, a PA PA 6 polyether block copolymer made by reaction injection molding and one made by reactive extrusion. To ensure good particle matrix bonding, the ethylene propylene copolymer was grafted with maleic anhydride (EPR-g-MA). Due to the molecular structure of the two block copolymers, a coupling agent was not necessary. The block copolymers are semi-crystalline and partially cross-linked in contrast to commonly used amorphous rubbers which are usually uncured. The combination of different analysis methods like atomic force microscopy (AFM), transmission electron microscopy (TEM) and scanning electron microscopy (SEM) gave a detailed view in the structure of the blends. Due to the partial cross-linking, the particles of the block copolymers in the blends are not spherical like the ones of ethylene propylene copolymer. The differences in molecular structure, miscibility and grafting of the impact modifiers result in different mechanical properties and different blend morphologies.

  15. Efficacy of histotripsy combined with rt-PA in vitro.

    PubMed

    Bader, Kenneth B; Haworth, Kevin J; Shekhar, Himanshu; Maxwell, Adam D; Peng, Tao; McPherson, David D; Holland, Christy K

    2016-07-21

    Histotripsy, a form of therapeutic ultrasound that uses the mechanical action of microbubble clouds for tissue ablation, is under development to treat chronic deep vein thrombosis (DVT). We hypothesize that combining thrombolytic agents with histotripsy will enhance clot lysis. Recombinant tissue plasminogen activator (rt-PA) and rt-PA-loaded echogenic liposomes that entrain octafluoropropane microbubbles (OFP t-ELIP) were used in combination with highly shocked histotripsy pulses. Fully retracted porcine venous clots, with similar features of DVT occlusions, were exposed either to histotripsy pulses alone (peak negative pressures of 7-20 MPa), histotripsy and OFP t-ELIP, or histotripsy and rt-PA. Microbubble cloud activity was monitored with passive cavitation imaging during histotripsy exposure. The power levels of cavitation emissions from within the clot were not statistically different between treatment types, likely due to the near instantaneous rupture and destruction of OFP t-ELIP. The thrombolytic efficacy was significantly improved in the presence of rt-PA. These results suggest the combination of histotripsy and rt-PA could serve as a potent therapeutic strategy for the treatment of DVT. PMID:27353199

  16. Efficacy of histotripsy combined with rt-PA in vitro

    NASA Astrophysics Data System (ADS)

    Bader, Kenneth B.; Haworth, Kevin J.; Shekhar, Himanshu; Maxwell, Adam D.; Peng, Tao; McPherson, David D.; Holland, Christy K.

    2016-07-01

    Histotripsy, a form of therapeutic ultrasound that uses the mechanical action of microbubble clouds for tissue ablation, is under development to treat chronic deep vein thrombosis (DVT). We hypothesize that combining thrombolytic agents with histotripsy will enhance clot lysis. Recombinant tissue plasminogen activator (rt-PA) and rt-PA-loaded echogenic liposomes that entrain octafluoropropane microbubbles (OFP t-ELIP) were used in combination with highly shocked histotripsy pulses. Fully retracted porcine venous clots, with similar features of DVT occlusions, were exposed either to histotripsy pulses alone (peak negative pressures of 7–20 MPa), histotripsy and OFP t-ELIP, or histotripsy and rt-PA. Microbubble cloud activity was monitored with passive cavitation imaging during histotripsy exposure. The power levels of cavitation emissions from within the clot were not statistically different between treatment types, likely due to the near instantaneous rupture and destruction of OFP t-ELIP. The thrombolytic efficacy was significantly improved in the presence of rt-PA. These results suggest the combination of histotripsy and rt-PA could serve as a potent therapeutic strategy for the treatment of DVT.

  17. Excited states of the odd-odd nucleus 230Pa

    NASA Astrophysics Data System (ADS)

    Kotthaus, T.; Reiter, P.; Hess, H.; Kalkühler, M.; Wendt, A.; Wiens, A.; Hertenberger, R.; Morgan, T.; Thirolf, P. G.; Wirth, H.-F.; Faestermann, T.

    2013-04-01

    The completely unknown spectrum of excited states of the odd-odd nucleus 230Pa was studied employing the one-neutron transfer reaction 231Pa(d,t)230Pa at a beam energy of 22 MeV. The excitation energy and the cross section were measured for, in total, 81 states below 1.4 MeV. Level assignments of these states are based on a semiempirical model and comparison with theoretical predictions, based on distorted-wave Born approximation (DWBA) calculations for the cross sections. For 12 rotational bands the band-head energy and the rotational parameter are determined. The K quantum numbers and the Nilsson configurations are established. Empirical values for the Gallagher-Moszkowski splittings and for Newby shifts are obtained.

  18. Impact of National Physical Activity and Health Guidelines and Documents on Research on Teaching K-12 Physical Education in U.S.A.

    ERIC Educational Resources Information Center

    Li, Weidong; Xiang, Ping; Gao, Zan; Shen, Bo; Yin, Zhihua; Kong, Qingtao

    2016-01-01

    Purpose: This study examined the impact of published national physical activity (PA) and health guidelines, documents, and initiatives on the evolution of research on teaching K-12 physical education (PE) in U.S.A. from 1996 to October 2013. Methods: A total of 262 peer-reviewed, data-based journal articles meeting our inclusion and exclusion…

  19. Oxidation of Gas-Phase Protactinium Ions, Pa+ and Pa2+: Formation and Properties of PaO22+(g), Protactinyl

    SciTech Connect

    Santos, M.; de Matos, A. Pires; Marcalo, J.; Gibson, John K; Haire, Richard {Dick} G; Tyagi, R.; Pitzer, R. M.

    2006-01-01

    Oxidation reactions of bare and ligated, monopositive, and dipositive Pa ions in the gas phase were studied by Fourier transform ion cyclotron resonance mass spectrometry. Seven oxidants were employed, ranging from the thermodynamically robust N{sub 2}O to the relatively weak CH{sub 2}O - all oxidized Pa{sup +} to PaO{sup +} and PaO{sup +} to PaO{sub 2}{sup +}. On the basis of experimental observations, it was established that D[Pa{sup +}-O] and D[OPa{sup +}-O] {ge} 751 kJ mol{sup -1}. Estimates for D[Pa{sup +}-O], D[OPa{sup +}-O], IE[PaO], and IE[PaO{sub 2}] were also obtained. The seven oxidants reacted with Pa{sup 2+} to produce PaO{sup 2+}, indicating that D[Pa{sup 2+}-O] {ge} 751 kJ mol{sup -1}. A particularly notable finding was the oxidation of PaO{sup 2+} by N{sub 2}O to PaO{sub 2}{sup 2+}, a species, which formally comprises Pa(VI). Collision-induced dissociation of PaO{sub 2}{sup 2+} suggested the protactinyl connectivity, {l_brace}O-Pa-O{r_brace}{sup 2+}. The experimentally determined IE[PaO{sub 2}{sup +}] {approx} 16.6 eV is in agreement with self-consistent-field and configuration interaction calculations for PaO{sub 2}{sup +} and PaO{sub 2}{sup 2+}. These calculations provide insights into the electronic structures of these ions and indicate the participation of 5f orbitals in bonding and a partial '6p hole' in the case of protactinyl. It was found that PaO{sub 2}{sup 2+} catalyzes the oxidation of CO by N{sub 2}O - such O atom transport via a dipositive metal oxide ion is distinctive. It was also observed that PaO{sub 2}{sup 2+} is capable of activating H{sub 2} to form the stable PaO{sub 2}H{sup 2+} ion.

  20. Pilomyxoid Astrocytoma (PMA) Shows Significant Differences in Gene Expression vs. Pilocytic Astrocytoma (PA) and Variable Tendency Toward Maturation to PA.

    PubMed

    Kleinschmidt-DeMasters, Bette K; Donson, Andrew M; Vogel, Hannes; Foreman, Nicholas K

    2015-07-01

    Pilomyxoid astrocytomas (PMAs) manifest a more aggressive clinical course than pilocytic astrocytomas (PAs). Development of effective therapies demands a better biological understanding of PMA. We first conducted gene expression microarray analysis of 9 PMA and 13 PA from infra- and supratentorial sites. Unsupervised hierarchical clustering analysis demonstrated that tumors are grouped according to anatomic site, not diagnosis. Gene expression profiles were then contrasted between eight PMAs and six PAs, all supratentorial/hypothalamic/chiasmal. Clinical outcome of PMAs varied, with four out of four patients with diencephalic syndrome succumbing to disease, one of whom showed bulky metastatic leptomeningeal spread at autopsy, with bimodal maturation to PA in some areas and de-differentiation to glioblastoma in others. A surviving child has undergone multiple surgical debulking, with progressive maturation to PA over time. Ontology-enrichment analysis identified overexpression in PMAs of extracellular matrix and mitosis-related genes. Genes overexpressed in PMA vs. PA, ranked according to fold-change, included developmental genes H19, DACT2, extracellular matrix collagens (COL2A1; COL1A1) and IGF2BP3 (IMP3), the latter previously identified as an adverse prognostic factor in PMA and PA. PMID:25521223

  1. Pilomyxoid astrocytoma (PMA) shows significant differences in gene expression versus pilocytic astrocytoma (PA) and variable tendency toward maturation to PA

    PubMed Central

    Kleinschmidt-DeMasters, B.K.; Donson, Andrew M.; Vogel, Hannes; Foreman, Nicholas K.

    2015-01-01

    Pilomyxoid astrocytomas (PMAs) manifest a more aggressive clinical course than pilocytic astrocytomas (PAs). Development of effective therapies demands a better biological understanding of PMA. We first conducted gene expression microarray analysis of 9 PMA and 13 PA from infra- and supra-tentorial sites. Unsupervised hierarchical clustering analysis demonstrated that tumors grouped according to anatomic site, not diagnosis. Gene expression profiles were then contrasted between 8 PMAs and 6 PAs, all supratentorial/hypothalamic/chiasmal. Clinical outcome of PMAs varied, with 4/4 patients with diencephalic syndrome succumbing to disease, one of whom showed bulky metastatic leptomeningeal spread at autopsy, with bimodal maturation to PA in some areas and de-differentiation to glioblastoma in others. A surviving child has undergone multiple surgical debulkings, with progressive maturation to PA over time. Ontology-enrichment analysis identified overexpression in PMAs of extracellular matrix and mitosis-related genes. Genes overexpressed in PMA versus PA, ranked according to fold-change, included developmental genes H19, DACT2, extracellular matrix collagens (COL2A1;COL1A1) and IGF2BP3 (IMP3), the latter previously identified as an adverse prognostic factor in PMA and PA. PMID:25521223

  2. Accreditation and implications of clinical postgraduate PA training programs.

    PubMed

    Hussaini, Sobia S; Bushardt, Reamer L; Gonsalves, Wanda C; Hilton, Virginia O; Hornberger, Brad J; Labagnara, Frank A; OʼHara, Kevin M; Sasek, Cody; Smith, Benjamin J; Williams, Jennifer S

    2016-05-01

    No consensus definition exists for postgraduate physician assistant (PA) training. This report from the AAPA Task Force on Accreditation of Postgraduate PA Training Programs describes the types of clinical training programs and their effects on hiring and compensation of PAs. Although completing a postgraduate program appears to have no effect on compensation, PAs who complete these programs may be favored in the hiring process and frequently report greater confidence in their skills. More research is needed and program accreditation is key to monitoring the effectiveness of these programs. PMID:27124222

  3. Modelling cerebral blood oxygenation using Monte Carlo XYZ-PA

    NASA Astrophysics Data System (ADS)

    Zam, Azhar; Jacques, Steven L.; Alexandrov, Sergey; Li, Youzhi; Leahy, Martin J.

    2013-02-01

    Continuous monitoring of cerebral blood oxygenation is critically important for the management of many lifethreatening conditions. Non-invasive monitoring of cerebral blood oxygenation with a photoacoustic technique offers advantages over current invasive and non-invasive methods. We introduce a Monte Carlo XYZ-PA to model the energy deposition in 3D and the time-resolved pressures and velocity potential based on the energy absorbed by the biological tissue. This paper outlines the benefits of using Monte Carlo XYZ-PA for optimization of photoacoustic measurement and imaging. To the best of our knowledge this is the first fully integrated tool for photoacoustic modelling.

  4. Shuttle GPS R/PA configuration and specification study

    NASA Technical Reports Server (NTRS)

    Booth, R. W. D.

    1979-01-01

    Changes in the technical specifications for a global positioning system (GPS) receiving system dedicated to space shuttle use are presented. Various hardware functions including acquisition, tracking, and measurement are emphasized. The anti-jam performance of the baseline GPS systems are evaluated. Other topics addressed include: the impact on R/PA design of the use of ground based transmitters; problems involved with the use of single channel tests sets; utility of various R/PA antenna interconnections topologies; the choice of the averaging interval for delta range measurements; and the use of interferometry techniques for the computation of orbiter attitude were undertaken.

  5. Associating a negatively charged GdDOTA-derivative to the Pittsburgh compound B for targeting Aβ amyloid aggregates.

    PubMed

    Martins, André F; Oliveira, Alexandre C; Morfin, Jean-François; Laurents, Douglas V; Tóth, Éva; Geraldes, Carlos F G C

    2016-03-01

    We have conjugated the tetraazacyclododecane-tetraacetate (DOTA) chelator to Pittsburgh compound B (PiB) forming negatively charged lanthanide complexes, Ln(L4), with targeting capabilities towards aggregated amyloid peptides. The amphiphilic Gd(L4) chelate undergoes micellar aggregation in aqueous solution, with a critical micellar concentration of 0.68 mM, lower than those for the neutral complexes of similar structure. A variable temperature (17)O NMR and NMRD study allowed the assessment of the water exchange rate, k ex (298) = 9.7 × 10(6) s(-1), about the double of GdDOTA, and for the description of the rotational dynamics for both the monomeric and the micellar forms of Gd(L4). With respect to the analogous neutral complexes, the negative charge induces a significant rigidity of the micelles formed, which is reflected by slower and more restricted local motion of the Gd(3+) centers as evidenced by higher relaxivities at 20-60 MHz. Surface Plasmon Resonance results indicate that the charge does not affect significantly the binding strength to Aβ1-40 [K d = 194 ± 11 μM for La(L4)], but it does enhance the affinity constant to human serum albumin [K a = 6530 ± 68 M(-1) for Gd(L4)], as compared to neutral counterparts. Protein-based NMR points to interaction of Gd(L4) with Aβ1-40 in the monomer state as well, in contrast to neutral complexes interacting only with the aggregated form. Circular dichroism spectroscopy monitored time- and temperature-dependent changes of the Aβ1-40 secondary structure, indicating that Gd(L4) stabilizes the random coil relative to the α-helix and β-sheet. TEM images confirm that the Gd(L4) complex reduces the formation of aggregated fibrils. PMID:26613605

  6. Development of a new dynamic gas flow-control system in the pressure range of 1 Pa-133 Pa

    SciTech Connect

    Hong, S. S.; Chung, J. W.; Khan, Wakil

    2011-12-15

    A new flow-control system (FCS-705) has been developed at Korea Research Institute of Standards and Science. The system is intended for calibration of vacuum gauges in the pressure range of 1 Pa-133 Pa by comparison method. This paper describes some basic characteristics of the system including; (1) the design and construction of the system, (2) the generation of stable pressures in the chamber, (3) achieving high upstream pressure limit by installing a short duct in the by-pass pumping line, and (4) investigation of the gas flow regimes within the short duct.

  7. Draft Genome Sequences of Pseudomonas fluorescens Strains PA4C2 and PA3G8 and Pseudomonas putida PA14H7, Three Biocontrol Bacteria against Dickeya Phytopathogens

    PubMed Central

    Cigna, Jérémy; Raoul des Essarts, Yannick; Mondy, Samuel; Hélias, Valérie; Beury-Cirou, Amélie

    2015-01-01

    Pseudomonas fluorescens strains PA4C2 and PA3G8 and Pseudomonas putida strain PA14H7 were isolated from potato rhizosphere and show an ability to inhibit the growth of Dickeya phytopathogens. Here, we report their draft genome sequences, which provide a basis for understanding the molecular mechanisms involved in antibiosis against Dickeya. PMID:25635023

  8. 78 FR 27025 - Modification of Class B Airspace; Philadelphia, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-09

    ... rulemaking (NPRM) to modify the Philadelphia, PA, Class B airspace area (77 FR 45290, July 31, 2012...: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389... aircraft within Class B airspace, reduce controller workload, and reduce the potential for midair...

  9. Women's weekend in ninth year. PinnacleHealth, Harrisburg, PA.

    PubMed

    Herreria, J

    1997-01-01

    For nine years, PinnacleHealth has lured busy women in the Harrisburg, Pa., area away for a weekend of pampering. It's a project of PinnacleHealth's WomanCare's Resource Center. The program began with 239 women, last year the event drew 400 participants. PMID:10174494

  10. 78 FR 12806 - Pennsylvania Disaster Number PA-00057

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-25

    ... ADMINISTRATION Pennsylvania Disaster Number PA-00057 AGENCY: U.S. Small Business Administration. ] ACTION.... ADDRESSES: Submit completed loan applications to: U.S. Small Business Administration, Processing and..., Office of Disaster Assistance, U.S. Small Business Administration, 409 3rd Street SW., Suite...

  11. 78 FR 48297 - Amendment of Class E Airspace; Bedford, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-08

    ... proposed rulemaking (NPRM) to amend Class E airspace at Bedford County Airport, Bedford, PA. (78 FR 32213...: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389... 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR...

  12. 78 FR 48296 - Amendment of Class E Airspace; Factoryville, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-08

    ... continues to read as follows: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3... Field Airport, Factoryville, PA, (78 FR, 32212). Interested parties were invited to participate in this... Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of...

  13. 75 FR 67911 - Amendment of Class E Airspace; Jeannette, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-04

    ... follows: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp... rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not... Federal Aviation Administration 14 CFR Part 71 Amendment of Class E Airspace; Jeannette, PA...

  14. ANALYSIS OF ATMOSPHERE DEPOSITION SAMPLES FROM EASTON, PA

    EPA Science Inventory

    The report gives results of an analysis of samples of tenacious atmospheric deposits on exposed surfaces (e.g., automobiles and houses) in an industrial area near Easton, PA. The analysis was made at the request of the State of Pennsylvania. The Pennsylvania Department of Environ...

  15. Existence under PA's Charter School Law: First Year Reports.

    ERIC Educational Resources Information Center

    Johnson, Addie M.

    This paper provides an update on how some new charter schools have fared during the first year of operation under Pennsylvania's charter school legislation (PA Act 22, June 1997). Data should facilitate an examination of the degree to which the legislation supports or inhibits the entrepreneurial school reform practice of charter schools. Twenty…

  16. Photofission of /sup 231/ Pa in the threshold region

    SciTech Connect

    Soldatov, A.S.; Rudnikov, V.E.; Aleksandrova, Z.A.; Smirenkin, G.N.; Tarasko, M.Z.

    1987-09-01

    Results are reported of yields, measured for the first time, and cross sections obtained from them for fission in the reaction /sup 231/ Pa(..gamma.., f ) for the ..gamma..-ray energy region 4.8--7.0 MeV.

  17. 76 FR 59503 - Establishment of Class E Airspace; Lebanon, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-27

    ... proposed rulemaking to amend Class E airspace 700 feet above the surface, at Lebanon, PA (76 FR 39038... Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a...: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p....

  18. 77 FR 47792 - Drawbridge Operation Regulation; Schuylkill River, Philadelphia, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-10

    ... FR 3316). Public Meeting We do not now plan to hold a public meeting. But you may submit a request... SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulation; Schuylkill River... River, mile 6.4 near Christian Street, at Philadelphia, PA. The proposed rule intends to change...

  19. 77 FR 63727 - Drawbridge Operation Regulation; Schuylkill River, Philadelphia, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-17

    ... Operation Regulation; Schuylkill River, Philadelphia, PA in the FR (77 FR 47792). We received no comments on... FR Federal Register NPRM Notice of Proposed Rulemaking Sec. Section Symbol U.S.C. United States Code... SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulation; Schuylkill...

  20. 32 CFR 701.124 - PA self assessments/inspections.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 5 2012-07-01 2012-07-01 false PA self assessments/inspections. 701.124 Section 701.124 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY UNITED STATES NAVY REGULATIONS AND OFFICIAL RECORDS AVAILABILITY OF DEPARTMENT OF THE NAVY RECORDS AND PUBLICATION OF DEPARTMENT OF THE NAVY DOCUMENTS AFFECTING...

  1. 32 CFR 701.124 - PA self assessments/inspections.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 5 2011-07-01 2011-07-01 false PA self assessments/inspections. 701.124 Section 701.124 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY UNITED STATES NAVY REGULATIONS AND OFFICIAL RECORDS AVAILABILITY OF DEPARTMENT OF THE NAVY RECORDS AND PUBLICATION OF DEPARTMENT OF THE NAVY DOCUMENTS AFFECTING...

  2. 32 CFR 701.124 - PA self assessments/inspections.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false PA self assessments/inspections. 701.124 Section 701.124 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY UNITED STATES NAVY REGULATIONS AND OFFICIAL RECORDS AVAILABILITY OF DEPARTMENT OF THE NAVY RECORDS AND PUBLICATION OF DEPARTMENT OF THE NAVY DOCUMENTS AFFECTING...

  3. Nuclear-physics characteristics of short-lived odd-odd {sup 232}Pa, {sup 238}Np and {sup 242g}Am nuclides (measurement results and prospects for further researches)

    SciTech Connect

    Fomushkin, Eduard F.; Abramovich, Sergei N.; Andreev, Mikhail F.

    1998-10-26

    In VNIIEF there were measured cross-sections of {sup 232}Pa and {sup 238}Np fission caused by thermal neutrons. The obtained data do not agree with the results of measurements carried out in Los Alamos National Laboratory (USA). Possible reasons of the result divergence are discussed. There are considered the measurement prospects for fission and radiation capture cross-sections of thermal neutrons by the nuclei of {sup 232}Pa, {sup 238}Np and {sup 242g}Am, including the measurements performed with the aid of ILL (Grenoble, France) reactor and some devices for neutron researches.

  4. FOREWORD: CCM Second International Seminar: Pressure Metrology from 1 kPa to 1 GPa

    NASA Astrophysics Data System (ADS)

    Molinar, G. F.

    1994-01-01

    The Comité Consultatif pour la Masse et les Grandeurs Apparentées (CCM), through its High Pressure and Medium Pressure Working Groups, organized this Second International Seminar on Pressure Metrology from 1 kPa to 1 GPa, which was held at the Laboratoire National d'Essais (LNE), Paris, France, from 2 to 4 June 1993. The scope of the seminar was to review the state of the art of pressure measurements in the 1 kPa to I GPa pressure range and to present innovative contributions by standards laboratories, universities and industry. The seminar was organized in six sessions: liquid-column manometers; piston gauge pressure standards; properties of liquids and gases relevant to pressure metrology; pressure transducers and transfer standards; pressure standard comparison (methods and results); dynamic pressure measurements. Each session opened with the presentation of a review paper on major requirements in that field and, at the end of the seminar, a general discussion was organized on the actual limits of accuracy of static and dynamic pressure measurements in fluid media, and the fundamental problems in pressure metrology between 1 kPa and 1 GPa. The seminar was attended by sixty scientists from twenty-four countries, all working in the field of pressure measurements. Forty-nine papers were presented. The participation of scientists from so many countries indicates the importance of pressure metrology from the scientific and industrial points of view. Most papers were presented by scientists from national standards laboratories, with eight papers from universities and four from industry. Eleven papers reported the results of cooperative work involving metrological institutions dealing with high pressure, generally national standards laboratories, an indication that scientific links are already well established at this level. Links are also strengthening between industry and standards laboratories. Although industrial participation at the seminar was relatively small

  5. 75 FR 70934 - U.S. Customs and Border Protection Accreditation and Approval of Intertek USA, Inc., as a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-19

    ...Notice is hereby given that, pursuant to 19 CFR 151.12 and 19 CFR 151.13, Intertek USA, Inc., 327 Erickson Ave., Essington, PA 19029, has been approved to gauge and accredited to test petroleum and petroleum products for customs purposes, in accordance with the provisions of 19 CFR 151.12 and 19 CFR 151.13. Anyone wishing to employ this entity to conduct laboratory analyses and gauger services......

  6. Apportionment of ambient primary and secondary pollutants during a 2001 summer study in Pittsburgh using U.S. Environmental Protection Agency UNMIX

    SciTech Connect

    Anderson, R.A.; Martello, D.V.; Lucas, L.J.; Davidson, C.I.; Modey, W.K.; Eatough, D.J.

    2006-09-15

    Apportionment of primary and secondary pollutants during the summer 2001 Pittsburgh Air Quality Study (PAQS) is reported. Several sites were included in PAQS, with the main site (the supersite) adjacent to the Carnegie Mellon University campus in Schenley Park. One of the additional sampling sites was located at the National Energy Technology Laboratory, 18 km southeast of Pittsburgh. Coal- and natural gas fired power plants were in the vicinity of NETL, as were coking plants; and metal and chemical plants. Plants burning bituminous coal and natural gas were near the supersite. Fine particulate matter (PM2.5) mass, gas-phase volatile organic material (VOM), particulate semivolatile and nonvolatile organic material (NVOM), and ammonium sulfate were apportioned at the two sites into their primary and secondary contributions using the U.S. Environmental Protection Agency UNMIX 2.3 multivariate receptor modeling and analysis software. A portion of each of these species was identified as originating from gasoline and diesel primary mobile sources. Some of the organic material was formed from local secondary transformation processes, whereas the great majority of the secondary sulfate was associated with regional transformation contributions. The results indicated that the diurnal patterns of secondary gas- phase VOM and particulate semivolatile and NVOM were not correlated with secondary ammonium sulfate contributions but were associated with separate formation pathways. These findings are consistent with the bulk of the secondary ammonium sulfate in the Pittsburgh area being the result of contributions from distant transport and, thus, decoupled from local activity involving organic pollutants in the metropolitan area. 19 refs., 14 figs., 4 tabs.

  7. Automated Measurements of Ambient Aerosol Chemical Composition and its Dry and Wet Size Distributions at Pittsburgh Supersite

    NASA Astrophysics Data System (ADS)

    Khlystov, A. Y.; Stanier, C.; Chun, W.; Vayenas, D.; Mandiro, M.; Pandis, S. N.

    2001-12-01

    Ambient aerosol particles change size with changes in ambient relative humidity. The magnitude of the size change depends on the hygroscopic properties of the particles, which is determined by their chemical composition. Hygroscopic properties of particles influence many environmentally important aerosol qualities, such as light scattering and partitioning between the gas and particle phases of semivolitile compounds. Studying the hygroscopic growth of ambient particles is thus of paramount importance. The highroscopic growth of ambient particles and their chemical composition are measured continuously within the Pittsburgh Air Quality Study (EPA supersite program). The hygroscopic size changes are measured using an automated system built for this study. The system consists of two Scanning Mobility Particle Sizers (SMPS, TSI Inc.) and an Aerodynamic Particle Sizer (APS, TSI Inc.). The three instruments measure aerosol size distribution between 5 nanometers and 10 micrometers in diameter. The inlets of the instruments and the sheath air lines of the SMPS systems are equipped with computer controlled valves that direct air through Nafion dryers (PermaPure Inc.) or bypass them. The Nafion dryers are drying the air stream below 40% RH at which point ambient particles are expected to lose most or all water and thus be virtually dry. To avoid changes in relative humidity and evaporation of volatile particles due to temperature differences the system is kept at ambient temperature. The system measures alternatively dry (below 40% RH) and wet (actual ambient RH) aerosol size distributions every 6 minutes. The hygroscopic growth observed with the size-spectrometer system is compared with theoretic predictions based on the chemical composition of aerosol particles. A modified semi-continuous Steam-Jet Aerosol Collector provides the total available budget (particles and gas) of water-soluble species, which is used as an input to the thermodynamic model. The model calculates

  8. Variability in clinical prevalence of PaV1 in Caribbean spiny lobsters occupying commercial casitas over a large bay in Mexico.

    PubMed

    Candia-Zulbarán, Rebeca I; Briones-Fourzán, Patricia; Negrete-Soto, Fernando; Barradas-Ortiz, Cecilia; Lozano-Álvarez, Enrique

    2012-08-27

    In Bahía de la Ascensión, Mexico, the fishery for spiny lobsters Panulirus argus is based on the extensive use of casitas, large artificial shelters that can harbor the full size range of these highly gregarious lobsters. The discovery of a pathogenic virus in these lobsters (Panulirus argus virus 1, or PaV1) has raised concern about its potential effects on casita-based fisheries. Because in Bahía de la Ascensión visibly infected lobsters represent an immediate loss of revenue, we examined variability in clinical prevalence of PaV1 (percentage of lobsters visibly infected) in thousands of lobsters sampled from the commercial catch at the onset of 3 consecutive fishing years, and from 530 casitas distributed over 3 zones within the bay during 2 fishing and 2 closed seasons. In the commercial catch (lobsters 67 to 147 mm carapace length [CL]), clinical prevalence of PaV1 was low and was not affected by year or sex. In lobsters (9.2 to 115.0 mm CL) that occupied casitas, clinical prevalence of PaV1 varied with sampling season and was always higher in juveniles than in subadults or adults, but was consistently lower in one zone relative to the other 2 zones. The average clinical prevalence of PaV1 in this bay was statistically similar to the average clinical prevalence reported in Cuba, where casitas are also used, and in Florida Bay, USA, where casitas are not used. To date, PaV1 has had no discernible impact on the lobster fishery in Bahía de la Ascensión, suggesting that clinical prevalence is not influenced by the use of casitas per se. PMID:23186700

  9. [Prostate specific antigen in patients with prostatic cancer--clinical usefulness of its measurement with sensitive enzyme immunoassay, TOSOH II PA assay].

    PubMed

    Shinka, T; Miyai, M; Sawada, Y; Ohkawa, T

    1994-10-01

    The TOSOH II PA (AIA-PACK PA in the U.S.A.) monoclonal immunoenzyme assay was used and the clinical usefulness of prostate specific antigen (PSA) was evaluated in 39 men with prostatic cancer and 32 men with benign prostatic hyperplasia (BPH) confirmed pathologically. We evaluated the lower limit of detection in this assay by the mean PSA level plue 3 standard deviations in 5 separate experiments with a zero control sera as well as the mean PSA level minus 3 standard deviations in 5 separate experiments with serial dilutions of a known concentration of PSA. PSA concentrations of 0 to 0.25 ng/ml could not be distinguished from the zero control. Therefore, we set the lower limit of detection for the assay as 0.25 ng/ml. At our laboratory, the normal standard value was determined by the mean PSA level plus 3 standard deviations in 79 healthy men as 2.3 ng/ml. Of patients that underwent radical cystoprostatectomy for bladder cancer, all had PSA levels less than 0.25 ng/ml, while only 6% had PAP levels less than 0.11 ng/ml, the lower limit of detection in the TOSOH II PAP assay. We compared TOSOH II PA with Markit PA, a commonly used assay in Japan. Although there was a close linear correlation (r = 0.90) between the TOSOH II PA and Markit PA, the difference of slope in the linear regression lines was great, it was thought due to anti-PSA antibodies in each assay recognizing different epitopes of PSA in the blood.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:7527470

  10. Functionalization of PET and PA6.6 woven fabrics

    NASA Astrophysics Data System (ADS)

    Bessada, R.; Silva, G.; Paiva, M. C.; Machado, A. V.

    2011-07-01

    In the present work as received woven fabrics of polyethylene terephthalate (PET) and polyamide 6.6 (PA6.6) were exposed to a continuous dielectric barrier discharge (DBD), in air at atmospheric pressure, at selected discharge power values and conveyor speeds. The chemical modification of the fabric surface was studied by contact angle analysis, attenuated total reflection (ATR)-FTIR spectroscopy and X-ray photoelectron spectroscopy (XPS). The results confirmed that the treatment changed the fabric surface chemistry, increasing its wettability by polar liquids and its oxygen content. Contact angle results showed different behaviour of the two polymer fabrics toward ageing effects; while PET showed a contact angle increase along the subsequent days of treatment, the PA6.6 fabric maintained its hydrophilicity even 15 days after treatment. The surface morphology analysed by scanning electron microscopy (SEM), did not show any significant difference before and after treatment.

  11. Structure of a putative acetyltransferase (PA1377) from Pseudomonas aeruginosa

    SciTech Connect

    Davies, Anna M.; Tata, Renée; Chauviac, François-Xavier; Sutton, Brian J.; Brown, Paul R.

    2008-05-01

    The crystal structure of an acetyltransferase encoded by the gene PA1377 from Pseudomonas aeruginosa has been determined at 2.25 Å resolution. Comparison with a related acetyltransferase revealed a structural difference in the active site that was taken to reflect a difference in substrate binding and/or specificity between the two enzymes. Gene PA1377 from Pseudomonas aeruginosa encodes a 177-amino-acid conserved hypothetical protein of unknown function. The structure of this protein (termed pitax) has been solved in space group I222 to 2.25 Å resolution. Pitax belongs to the GCN5-related N-acetyltransferase family and contains all four sequence motifs conserved among family members. The β-strand structure in one of these motifs (motif A) is disrupted, which is believed to affect binding of the substrate that accepts the acetyl group from acetyl-CoA.

  12. A new antithrombogenic RV-PA valved conduit.

    PubMed

    Ichikawa, Y; Noishiki, Y; Soma, T; Ishii, M; Yamamoto, K; Takahashi, K; Mo, M; Kosuge, T; Kondo, J; Matsumoto, A

    1994-01-01

    A new antithrombogenic right ventricular (RV)-pulmonary artery (PA) valved conduit was developed using a bovine jugular vein containing a natural valve. To maintain the natural and mechanical properties of the venous tissue, a hydrophilic cross-linking reagent, glycerol polyglycidyl ether polyepoxy compound (PC) was used instead of glutaraldehyde (GA). Moreover, to induce antithrombogenicity, heparin was bonded to the inner surface of the bovine jugular vein cross-linked with PC. Conduits of 18 to 20 mm inner diameter (ID) were implanted between the RV and PA in nine dogs weighing 7-17 kg, with the native main PA being ligated proximally. The handling and suturing of the graft was easy and adaptable, and the anastomosis was completed with excellent coaptation and no blood leakage at the suture lines. All animals were chronic survivors, but one animal died of hematemesis on the 438th postoperative day. Grafts were explanted from 182 to 385 days after implantation. The luminal surface of the conduits were white, glistening, and smooth with good coaptation of the cusps, without calcification or degenerative changes except for one cusp that showed a minimal deformation with a small thrombus. Macroscopic and microscopic observation showed that there were no thrombi at the anastomotic lines, but small thrombi on the luminal surface of the conduits near the cusps and in some cusps. Endothelium-like cells were noticed on the luminal surface of the graft, except in the area near the cusps, and on one cusp at 196 days after surgery. These results indicated that the new RV-PA valved conduit provided adequate antithrombogenicity by temporary slow heparin release, followed later by endothelialization of the graft in a low pressure system at 1 year after implantation. PMID:8555607

  13. Demonstration Assessment of LED Roadway Lighting: Philadelphia, PA

    SciTech Connect

    Royer, Michael P.; Tuenge, Jason R.; Poplawski, Michael E.

    2012-09-01

    For this demonstration assessment, 10 different groups of LED luminaires were installed at three sites in Philadelphia, PA. Each of the three sites represented a different set of conditions, most importantly with regard to the incumbent HPS luminaires, which were nominally 100 W, 150 W, and 250 W. The performance of each product was evaluated based on manufacturer data, illuminance calculations, field measurements of illuminance, and the subjective impressions of both regular and expert observers.

  14. Possible ground-state octupole deformation in /sup 229/Pa

    SciTech Connect

    Ahmad, I.; Gindler, J.E.; Betts, R.R.; Chasman, R.R.; Friedman, A.M.

    1982-12-13

    Evidence is presented for the occurrence of a (5/2)/sup + -/ parity doublet as the ground state of /sup 229/Pa, in agreement with a previous theoretical prediction. The doublet splitting energy is measured to be 0.22 +- 0.05 keV. The relation of this doublet to ground-state octupole deformation is discussed. .ID LV2109 .PG 1762 1764

  15. Metlab Plant-Wide Assessment (Metlab in Wyndmoor, PA)

    SciTech Connect

    2002-08-01

    This OIT BestPractices case study describes the methods and results of a plant-wide energy assessment at Metlab's aircraft component manufacturing plant in Wyndmoor, PA. Recommendations derived from the assessment, if implemented, can save an estimated $528,400 annually, reduce natural gas use by 50,070 MMbtu per year, and reduce electrical use by 329,400 kWh per year.

  16. PA3297 Counteracts Antimicrobial Effects of Azithromycin in Pseudomonas aeruginosa

    PubMed Central

    Tan, Hao; Zhang, Lu; Weng, Yuding; Chen, Ronghao; Zhu, Feng; Jin, Yongxin; Cheng, Zhihui; Jin, Shouguang; Wu, Weihui

    2016-01-01

    Pseudomonas aeruginosa causes acute and chronic infections in human. Its increasing resistance to antibiotics requires alternative treatments that are more effective than available strategies. Among the alternatives is the unconventional usage of conventional antibiotics, of which the macrolide antibiotic azithromycin (AZM) provides a paradigmatic example. AZM therapy is associated with a small but consistent improvement in respiratory function of cystic fibrosis patients suffering from chronic P. aeruginosa infection. Besides immunomodulating activities, AZM represses bacterial genes involved in virulence, quorum sensing, biofilm formation, and motility, all of which are due to stalling of ribosome and depletion of cellular tRNA pool. However, how P. aeruginosa responds to and counteracts the effects of AZM remain elusive. Here, we found that deficiency of PA3297, a gene encoding a DEAH-box helicase, intensified AZM-mediated bacterial killing, suppression of pyocyanin production and swarming motility, and hypersusceptibility to hydrogen peroxide. We demonstrated that expression of PA3297 is induced by the interaction between AZM and ribosome. Importantly, mutation of PA3297 resulted in elevated levels of unprocessed 23S-5S rRNA in the presence of AZM, which might lead to increased susceptibility to AZM-mediated effects. Our results revealed one of the bacterial responses in counteracting the detrimental effects of AZM. PMID:27014238

  17. PA0148 from Pseudomonas aeruginosa Catalyzes the Deamination of Adenine

    SciTech Connect

    Goble, A.M.; Swaminathan, S.; Zhang, Z.; Sauder, J. M.; Burley, S. K.; Raushel, F. M.

    2011-08-02

    Four proteins from NCBI cog1816, previously annotated as adenosine deaminases, have been subjected to structural and functional characterization. Pa0148 (Pseudomonas aeruginosa PAO1), AAur1117 (Arthrobacter aurescens TC1), Sgx9403e, and Sgx9403g have been purified and their substrate profiles determined. Adenosine is not a substrate for any of these enzymes. All of these proteins will deaminate adenine to produce hypoxanthine with k{sub cat}/K{sub m} values that exceed 10{sup 5} M{sup -1} s{sup -1}. These enzymes will also accept 6-chloropurine, 6-methoxypurine, N-6-methyladenine, and 2,6-diaminopurine as alternate substrates. X-ray structures of Pa0148 and AAur1117 have been determined and reveal nearly identical distorted ({beta}/{alpha}){sub 8} barrels with a single zinc ion that is characteristic of members of the amidohydrolase superfamily. Structures of Pa0148 with adenine, 6-chloropurine, and hypoxanthine were also determined, thereby permitting identification of the residues responsible for coordinating the substrate and product.

  18. Pa0148 from Pseudomonas aeruginosa Catalyzes the Deamination of Adenine

    SciTech Connect

    A Goble; Z Zhang; J Sauder; S Burley; S Swaminathan; F Raushel

    2011-12-31

    Four proteins from NCBI cog1816, previously annotated as adenosine deaminases, have been subjected to structural and functional characterization. Pa0148 (Pseudomonas aeruginosa PAO1), AAur1117 (Arthrobacter aurescens TC1), Sgx9403e, and Sgx9403g have been purified and their substrate profiles determined. Adenosine is not a substrate for any of these enzymes. All of these proteins will deaminate adenine to produce hypoxanthine with k{sub cat}/K{sub m} values that exceed 10{sup 5} M{sup -1} s{sup -1}. These enzymes will also accept 6-chloropurine, 6-methoxypurine, N-6-methyladenine, and 2,6-diaminopurine as alternate substrates. X-ray structures of Pa0148 and AAur1117 have been determined and reveal nearly identical distorted ({beta}/{alpha}){sub 8} barrels with a single zinc ion that is characteristic of members of the amidohydrolase superfamily. Structures of Pa0148 with adenine, 6-chloropurine, and hypoxanthine were also determined, thereby permitting identification of the residues responsible for coordinating the substrate and product.

  19. Thermal degradation of PA66 during laser transmission welding

    NASA Astrophysics Data System (ADS)

    Wang, Xiao; Guo, Dehui; Chen, Guochun; Jiang, Hairong; Meng, Dongdong; Yan, Zhang; Liu, Huixia

    2016-09-01

    The thermal degradation of materials strongly influences the weld strength in laser transmission welding (LTW). Weld strength decreases at high temperatures because of material thermal degradation. Hence, it is necessary to investigate this phenomenon. Thermal degradation of polyamide 66 (PA66) was predicted by combining a pyrolysis kinetic model with a 3-D transient thermal model. Thermogravimetric analysis (TGA) was used to study the pyrolysis characteristic of PA66. The TGA data were used to obtain kinetic parameters of PA66 using an nth order model in MATLAB. In addition, material conversion as a function of temperature (time) was analyzed using this kinetic reaction model containing the relevant kinetic parameters. A 3-D transient thermal model based on a volumetric heat source was developed. The temperature-time data of the point located at the maximum temperature was predicted through this thermal analysis model under different weld parameters. This study demonstrates that the predicted power at which the material starts to degrade is generally consistent with the power at which shear strength begins to decrease. The present studies lay a theoretical foundation for the investigation of thermal degradation during LTW.

  20. PA3297 Counteracts Antimicrobial Effects of Azithromycin in Pseudomonas aeruginosa.

    PubMed

    Tan, Hao; Zhang, Lu; Weng, Yuding; Chen, Ronghao; Zhu, Feng; Jin, Yongxin; Cheng, Zhihui; Jin, Shouguang; Wu, Weihui

    2016-01-01

    Pseudomonas aeruginosa causes acute and chronic infections in human. Its increasing resistance to antibiotics requires alternative treatments that are more effective than available strategies. Among the alternatives is the unconventional usage of conventional antibiotics, of which the macrolide antibiotic azithromycin (AZM) provides a paradigmatic example. AZM therapy is associated with a small but consistent improvement in respiratory function of cystic fibrosis patients suffering from chronic P. aeruginosa infection. Besides immunomodulating activities, AZM represses bacterial genes involved in virulence, quorum sensing, biofilm formation, and motility, all of which are due to stalling of ribosome and depletion of cellular tRNA pool. However, how P. aeruginosa responds to and counteracts the effects of AZM remain elusive. Here, we found that deficiency of PA3297, a gene encoding a DEAH-box helicase, intensified AZM-mediated bacterial killing, suppression of pyocyanin production and swarming motility, and hypersusceptibility to hydrogen peroxide. We demonstrated that expression of PA3297 is induced by the interaction between AZM and ribosome. Importantly, mutation of PA3297 resulted in elevated levels of unprocessed 23S-5S rRNA in the presence of AZM, which might lead to increased susceptibility to AZM-mediated effects. Our results revealed one of the bacterial responses in counteracting the detrimental effects of AZM. PMID:27014238

  1. PA-30 Twin Comanche - NASA 808 in flight

    NASA Technical Reports Server (NTRS)

    1979-01-01

    Dryden Flight Research Center's Piper PA-30 Twin Commanche, which helped validate the RPRV concept, descends to a remotely controlled landing on Rogers Dry Lake, unassisted by the onboard pilot. A Piper PA-30 Twin Commanche, known as NASA 808, was used at the NASA Dryden Flight Research Center as a rugged workhorse in a variety of research projects associated with both general aviation and military projects. In the early 1970s, the PA-30, serial number 301498, was used to test a flight technique used to fly Remotely Piloted Research Vehicles (RPRV's). The technique was first tested with the cockpit windows of the light aircraft blacked out while the pilot flew the aircraft utilizing a television monitor which gave him a 'pilot's eye' view ahead of the aircraft. Later pilots flew the aircraft from a ground cockpit, a procedure used with all RPRV's. TV and two-way telemetry allow the pilot to be in constant control of the aircraft. The apparatus mounted over the cockpit is a special fish eye lens camera, used to obtain images that are transmitted to the ground based cockpit. This project paved the way for sophisticated, highly successful research programs involving high risk spin, stall, and flight control conditions, such as the HiMAT and the subscale F-15 remotely piloted vehicles. Over the years, NASA 808 has also been used for spin and stall research related to general aviation aircraft and also research to alleviate wake vortices behind large jetliners.

  2. Rainfed farming systems in the USA

    Technology Transfer Automated Retrieval System (TEKTRAN)

    This chapter on rainfed farming systems in the USA describes characteristics of four major rainfed farming regions in the USA: Great Plains wheat-sorghum-cattle region, midwestern corn-soybean-hogs region, southern cotton-peanut-poultry region, and coastal diversified crops-dairy region. Rainfed fa...

  3. WOMEN-S HEALTH USA 2002

    EPA Science Inventory

    Women's Health USA 2002, the first annual report on the health status of America's women is presented by the HRSA's Maternal and Child Health Bureau (MCHB) and the Office of Women's Health. This first edition of the Women's Health USA data book brings together key facts and figur...

  4. "USA Today": Can the Nation's Newspaper Survive?

    ERIC Educational Resources Information Center

    Wicks, Robert H.

    The failure of 17 newspaper markets between 1957 and 1975 raises the question of whether the 1982 entrance of "USA Today" into the newspaper market demonstrated fiscal prudence. A 20-month advertising content analysis was conducted to assess advertising trends in "USA Today." These data were compared with industry statistics obtained from Media…

  5. The novel influenza A virus protein PA-X and its naturally deleted variant show different enzymatic properties in comparison to the viral endonuclease PA

    PubMed Central

    Bavagnoli, Laura; Cucuzza, Stefano; Campanini, Giulia; Rovida, Francesca; Paolucci, Stefania; Baldanti, Fausto; Maga, Giovanni

    2015-01-01

    The PA protein of Influenza A virus (IAV) encoded by segment 3 acts as a specialized RNA endonuclease in the transcription of the viral genome. The same genomic segment encodes for a second shorter protein, termed PA-X, with the first 191 N-terminal aminoacids (aa) identical to PA, but with a completely different C-ter domain of 61 aa, due to a ribosomal frameshifting. In addition, it has been shown that several IAV isolates encode for a naturally truncated PA-X variant, PAXΔC20, missing the last 20 aa. The biochemical properties of PA-X and PAXΔC20 have been poorly investigated so far. Here, we have carried out an enzymatic characterization of PA-X and its naturally deleted form, in comparison with PA from the human IAV strain A/WSN/33 (H1N1). Our results showed, to the best of our knowledge for the first time, that PA-X possesses an endonucleolytic activity. Both PA and PA-X preferentially cut single stranded RNA regions, but with some differences. In addition, we showed that PAXΔC20 has severely reduced nuclease activity. These results point to a previously undetected role of the last C-ter 20 aa for the catalytic activity of PA-X and support distinct roles for these proteins in the viral life cycle. PMID:26384413

  6. The novel influenza A virus protein PA-X and its naturally deleted variant show different enzymatic properties in comparison to the viral endonuclease PA.

    PubMed

    Bavagnoli, Laura; Cucuzza, Stefano; Campanini, Giulia; Rovida, Francesca; Paolucci, Stefania; Baldanti, Fausto; Maga, Giovanni

    2015-10-30

    The PA protein of Influenza A virus (IAV) encoded by segment 3 acts as a specialized RNA endonuclease in the transcription of the viral genome. The same genomic segment encodes for a second shorter protein, termed PA-X, with the first 191 N-terminal aminoacids (aa) identical to PA, but with a completely different C-ter domain of 61 aa, due to a ribosomal frameshifting. In addition, it has been shown that several IAV isolates encode for a naturally truncated PA-X variant, PAXΔC20, missing the last 20 aa. The biochemical properties of PA-X and PAXΔC20 have been poorly investigated so far. Here, we have carried out an enzymatic characterization of PA-X and its naturally deleted form, in comparison with PA from the human IAV strain A/WSN/33 (H1N1). Our results showed, to the best of our knowledge for the first time, that PA-X possesses an endonucleolytic activity. Both PA and PA-X preferentially cut single stranded RNA regions, but with some differences. In addition, we showed that PAXΔC20 has severely reduced nuclease activity. These results point to a previously undetected role of the last C-ter 20 aa for the catalytic activity of PA-X and support distinct roles for these proteins in the viral life cycle. PMID:26384413

  7. Dyslexia laws in the USA.

    PubMed

    Youman, Martha; Mather, Nancy

    2013-07-01

    Throughout the various states of the USA, the appropriate identification of dyslexia and the timely provision of interventions are characterized by variability and inconsistency. Several states have recognized the existence of this disorder and the well-established need for services. These states have taken proactive steps to implement laws and regulations for both identification and treatment, and the provision of equal access to students who are diagnosed with dyslexia. The majority of states, however, have not developed such laws and guidelines. The purposes of this article are to review the present status and content of these dyslexia laws, highlight some differences among the laws and regulations across states, and suggest strategies for initiating such laws. PMID:23086699

  8. University-School-Community Partnership as Vehicle for Leadership, Service, and Change: A Critical Brokerage Perspective

    ERIC Educational Resources Information Center

    Hopson, Rodney; Miller, Peter; Lovelace, Temple S.

    2016-01-01

    Using a critical brokerage perspective to advance theoretical insights in the development of a community university partnership and understanding of the organizational embeddedness of a community empowerment agency in Pittsburgh, PA, USA, this article suggests that partnerships between American universities and communities are perfect vehicles for…

  9. Cumberland and Pittsburgh 1/sup 0/ x 2/sup 0/ NTMS areas Maryland, Pennsylvania, Virginia, and West Virginia: data report (abbreviated). National uranium resource evaluation program, hydrogeochemical and stream sediment reconnaissance

    SciTech Connect

    Fay, W.M.

    1981-07-01

    This report summarizes results of ground water, surface water, and stream sediment reconnaissance in the National Topographic Map Series (NTMS) Cumberland and Pittsburgh 1/sup 0/ x 2/sup 0/ NTMS quadrangles. Surface sediment samples were collected at 1042 sites in the Cumberland quadrangle and 342 sites in the Pittsburgh quadrangle. Ground water samples were collected at 1240 sites in the Cumberland quadrangle and 467 sites in the Pittsburgh quadrangle. Neutron activation analysis results are given for uranium and 16 other elements in sediments, for uranium and 8 other elements in ground water, and for uranium and 9 other elements in surface water. Field measurements and observations are reported for each site. Analytical data and field measurements are presented in tables and maps.

  10. Experimental Results on Jets in pA

    NASA Astrophysics Data System (ADS)

    Appelt, Eric

    2015-04-01

    The experimentally observed reduction of jet yields in ultrarelativistic heavy ion (AA) collisions relative to proton-proton (pp) collisions is widely interpreted in terms of energy loss of a hard scattered parton traversing a quark-gluon plasma (QGP) before fragmenting into a jet of hadrons. In order to constrain proposed mechanisms of energy loss, a variety of measurements are needed that quantify both how the jet yields and jet structure are modified in the medium. However, jets may also be modified by differences in the initial state of the nucleus relative to that of the proton. The precise determination of the QGP properties relies on disentangling these additional modifications, collectively termed ``cold nuclear matter'' effects, from energy loss in the QGP. Collisions between heavy ions and protons (pA) provide a potential control environment where cold nuclear matter effects should be present, but QGP formation is generally not expected to occur. In this talk, an overview of recent jet results from proton-lead collisions produced at the LHC will be given. The yield of inclusive jets and distributions of dijet pairs are shown to be compatible with generally accepted theoretical expectations, although significant modification is observed when yields are measured from specific centrality classes of pA collision events. Some measurements of high-pT charged hadron yields suggest a larger modification in pA collisions relative to pp collisions than for inclusive jet yields. The potential implications of this difference along with other measurements relating to jet structure will be discussed.

  11. Atomic Mass and Nuclear Binding Energy for Pa-315 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-315 (Protactinium, atomic number Z = 91, mass number A = 315).

  12. Atomic Mass and Nuclear Binding Energy for Pa-282 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-282 (Protactinium, atomic number Z = 91, mass number A = 282).

  13. Atomic Mass and Nuclear Binding Energy for Pa-288 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-288 (Protactinium, atomic number Z = 91, mass number A = 288).

  14. Atomic Mass and Nuclear Binding Energy for Pa-283 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-283 (Protactinium, atomic number Z = 91, mass number A = 283).

  15. Atomic Mass and Nuclear Binding Energy for Pa-291 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-291 (Protactinium, atomic number Z = 91, mass number A = 291).

  16. Atomic Mass and Nuclear Binding Energy for Pa-253 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-253 (Protactinium, atomic number Z = 91, mass number A = 253).

  17. Atomic Mass and Nuclear Binding Energy for Pa-250 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-250 (Protactinium, atomic number Z = 91, mass number A = 250).

  18. Atomic Mass and Nuclear Binding Energy for Pa-251 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-251 (Protactinium, atomic number Z = 91, mass number A = 251).

  19. Atomic Mass and Nuclear Binding Energy for Pa-260 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-260 (Protactinium, atomic number Z = 91, mass number A = 260).

  20. Atomic Mass and Nuclear Binding Energy for Pa-281 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-281 (Protactinium, atomic number Z = 91, mass number A = 281).

  1. Atomic Mass and Nuclear Binding Energy for Pa-316 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-316 (Protactinium, atomic number Z = 91, mass number A = 316).

  2. Atomic Mass and Nuclear Binding Energy for Pa-284 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-284 (Protactinium, atomic number Z = 91, mass number A = 284).

  3. Atomic Mass and Nuclear Binding Energy for Pa-305 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-305 (Protactinium, atomic number Z = 91, mass number A = 305).

  4. Atomic Mass and Nuclear Binding Energy for Pa-298 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-298 (Protactinium, atomic number Z = 91, mass number A = 298).

  5. Atomic Mass and Nuclear Binding Energy for Pa-266 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-266 (Protactinium, atomic number Z = 91, mass number A = 266).

  6. Atomic Mass and Nuclear Binding Energy for Pa-247 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-247 (Protactinium, atomic number Z = 91, mass number A = 247).

  7. Atomic Mass and Nuclear Binding Energy for Pa-297 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-297 (Protactinium, atomic number Z = 91, mass number A = 297).

  8. Atomic Mass and Nuclear Binding Energy for Pa-268 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-268 (Protactinium, atomic number Z = 91, mass number A = 268).

  9. Atomic Mass and Nuclear Binding Energy for Pa-257 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-257 (Protactinium, atomic number Z = 91, mass number A = 257).

  10. Atomic Mass and Nuclear Binding Energy for Pa-300 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-300 (Protactinium, atomic number Z = 91, mass number A = 300).

  11. Atomic Mass and Nuclear Binding Energy for Pa-273 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-273 (Protactinium, atomic number Z = 91, mass number A = 273).

  12. Atomic Mass and Nuclear Binding Energy for Pa-248 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-248 (Protactinium, atomic number Z = 91, mass number A = 248).

  13. Atomic Mass and Nuclear Binding Energy for Pa-299 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-299 (Protactinium, atomic number Z = 91, mass number A = 299).

  14. Atomic Mass and Nuclear Binding Energy for Pa-287 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-287 (Protactinium, atomic number Z = 91, mass number A = 287).

  15. Atomic Mass and Nuclear Binding Energy for Pa-272 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-272 (Protactinium, atomic number Z = 91, mass number A = 272).

  16. Atomic Mass and Nuclear Binding Energy for Pa-279 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-279 (Protactinium, atomic number Z = 91, mass number A = 279).

  17. Atomic Mass and Nuclear Binding Energy for Pa-302 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-302 (Protactinium, atomic number Z = 91, mass number A = 302).

  18. Atomic Mass and Nuclear Binding Energy for Pa-289 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-289 (Protactinium, atomic number Z = 91, mass number A = 289).

  19. Atomic Mass and Nuclear Binding Energy for Pa-267 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-267 (Protactinium, atomic number Z = 91, mass number A = 267).

  20. Atomic Mass and Nuclear Binding Energy for Pa-252 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-252 (Protactinium, atomic number Z = 91, mass number A = 252).

  1. Atomic Mass and Nuclear Binding Energy for Pa-259 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-259 (Protactinium, atomic number Z = 91, mass number A = 259).

  2. Atomic Mass and Nuclear Binding Energy for Pa-265 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-265 (Protactinium, atomic number Z = 91, mass number A = 265).

  3. Atomic Mass and Nuclear Binding Energy for Pa-278 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-278 (Protactinium, atomic number Z = 91, mass number A = 278).

  4. Atomic Mass and Nuclear Binding Energy for Pa-285 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-285 (Protactinium, atomic number Z = 91, mass number A = 285).

  5. Atomic Mass and Nuclear Binding Energy for Pa-269 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-269 (Protactinium, atomic number Z = 91, mass number A = 269).

  6. Atomic Mass and Nuclear Binding Energy for Pa-246 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-246 (Protactinium, atomic number Z = 91, mass number A = 246).

  7. Atomic Mass and Nuclear Binding Energy for Pa-308 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-308 (Protactinium, atomic number Z = 91, mass number A = 308).

  8. Atomic Mass and Nuclear Binding Energy for Pa-274 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-274 (Protactinium, atomic number Z = 91, mass number A = 274).

  9. Atomic Mass and Nuclear Binding Energy for Pa-276 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-276 (Protactinium, atomic number Z = 91, mass number A = 276).

  10. Atomic Mass and Nuclear Binding Energy for Pa-256 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-256 (Protactinium, atomic number Z = 91, mass number A = 256).

  11. Atomic Mass and Nuclear Binding Energy for Pa-304 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-304 (Protactinium, atomic number Z = 91, mass number A = 304).

  12. Atomic Mass and Nuclear Binding Energy for Pa-270 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-270 (Protactinium, atomic number Z = 91, mass number A = 270).

  13. Atomic Mass and Nuclear Binding Energy for Pa-249 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-249 (Protactinium, atomic number Z = 91, mass number A = 249).

  14. Atomic Mass and Nuclear Binding Energy for Pa-271 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-271 (Protactinium, atomic number Z = 91, mass number A = 271).

  15. Atomic Mass and Nuclear Binding Energy for Pa-292 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-292 (Protactinium, atomic number Z = 91, mass number A = 292).

  16. Atomic Mass and Nuclear Binding Energy for Pa-290 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-290 (Protactinium, atomic number Z = 91, mass number A = 290).

  17. Atomic Mass and Nuclear Binding Energy for Pa-261 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-261 (Protactinium, atomic number Z = 91, mass number A = 261).

  18. Atomic Mass and Nuclear Binding Energy for Pa-280 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-280 (Protactinium, atomic number Z = 91, mass number A = 280).

  19. Atomic Mass and Nuclear Binding Energy for Pa-275 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-275 (Protactinium, atomic number Z = 91, mass number A = 275).

  20. Atomic Mass and Nuclear Binding Energy for Pa-306 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-306 (Protactinium, atomic number Z = 91, mass number A = 306).

  1. Atomic Mass and Nuclear Binding Energy for Pa-255 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-255 (Protactinium, atomic number Z = 91, mass number A = 255).

  2. Atomic Mass and Nuclear Binding Energy for Pa-301 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-301 (Protactinium, atomic number Z = 91, mass number A = 301).

  3. Atomic Mass and Nuclear Binding Energy for Pa-314 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-314 (Protactinium, atomic number Z = 91, mass number A = 314).

  4. Atomic Mass and Nuclear Binding Energy for Pa-293 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-293 (Protactinium, atomic number Z = 91, mass number A = 293).

  5. Atomic Mass and Nuclear Binding Energy for Pa-295 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-295 (Protactinium, atomic number Z = 91, mass number A = 295).

  6. Atomic Mass and Nuclear Binding Energy for Pa-307 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-307 (Protactinium, atomic number Z = 91, mass number A = 307).

  7. Atomic Mass and Nuclear Binding Energy for Pa-303 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-303 (Protactinium, atomic number Z = 91, mass number A = 303).

  8. Atomic Mass and Nuclear Binding Energy for Pa-254 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-254 (Protactinium, atomic number Z = 91, mass number A = 254).

  9. Atomic Mass and Nuclear Binding Energy for Pa-296 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-296 (Protactinium, atomic number Z = 91, mass number A = 296).

  10. Atomic Mass and Nuclear Binding Energy for Pa-263 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-263 (Protactinium, atomic number Z = 91, mass number A = 263).

  11. Atomic Mass and Nuclear Binding Energy for Pa-286 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-286 (Protactinium, atomic number Z = 91, mass number A = 286).

  12. Atomic Mass and Nuclear Binding Energy for Pa-262 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-262 (Protactinium, atomic number Z = 91, mass number A = 262).

  13. Atomic Mass and Nuclear Binding Energy for Pa-258 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-258 (Protactinium, atomic number Z = 91, mass number A = 258).

  14. Atomic Mass and Nuclear Binding Energy for Pa-294 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-294 (Protactinium, atomic number Z = 91, mass number A = 294).

  15. Atomic Mass and Nuclear Binding Energy for Pa-264 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-264 (Protactinium, atomic number Z = 91, mass number A = 264).

  16. Atomic Mass and Nuclear Binding Energy for Pa-277 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-277 (Protactinium, atomic number Z = 91, mass number A = 277).

  17. Processing of FENDL-PA/1.1

    SciTech Connect

    Mann, F.M.; Lessor, D.E.; Carter, L.L.

    1994-02-01

    The Fusion Evaluated Nuclear Data Library (FENDL) is an evaluated nuclear data library based upon the best evaluations from the world community. The library is maintained by the Nuclear Data Section of the International Atomic Energy Agency (IAEA). However, before the data can be used in computer codes, it must be processed into the appropriate format. The library containing the transmutation (or activation) cross sections that are part of FENDL is designated as FENDL-PA (P designating pointwise). The evaluations in Version 1.1 of this activation library were selected in the following two steps. For the most important reactions ({approximately}250), consultants to the IAEA compared evaluations submitted for consideration with experimental data. These evaluations included those from ENDF/B, JEF, BROND, JENDL, as well as ``complete`` activation libraries, such as EAF and REAC. The consultants then chose the ``best`` evaluation for each of the reactions. The evaluations for the remaining ({approximately}12,000) reactions were taken from EAF-3. The pointwise FENDL-PA/1.1 activation library was processed into two formats. Continuous energy format as used by the Monte Carlo neutron/photon transport code MCNP. ASCII 175 group multigroup format as used by the transmutation code REAC*2/3.

  18. SUPPLEMENTARY COMPARISON: Negative gauge pressure comparison: range -95 kPa to +95 kPa (EURAMET Project 1131)

    NASA Astrophysics Data System (ADS)

    Rantanen, Markku; Saxholm, Sari; Altintas, Aykurt; Pavis, Richard; Peterson, Guliko

    2010-01-01

    A pressure comparison in the negative gauge pressure range was arranged in 2009. The participating laboratories were CMI/Czech Republic, FORCE Technology/Denmark, AS Metrosert/Estonia and MIKES/Finland. Negative gauge pressures are a common range for pressure calibrations although uncertainty requirements are generally not very high. The results from the four participating laboratories suggest that calibrations in the negative gauge pressure range are not as easy as expected. Some of the claimed uncertainties were perhaps too optimistic, and the large variation in the results made it difficult to generate consistent reference values. The agreement of the results at positive gauge pressures on the same transfer standard was much better. Obviously there is a need for further comparisons in the negative gauge pressure range. The transfer standard was a multifunction calibrator Beamex MC5 equipped with an internal pressure module for the range -100 kPa to 104 kPa in the gauge mode. The resolution of the display was 0.001 kPa. The stability of the transfer standard was good. The comparison was registered as EURAMET Project No. 1131 and as the supplementary comparison EURAMET.M.P-S8 in the BIPM key comparison database. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by EURAMET, according to the provisions of the CIPM Mutual Recognition Arrangement (MRA).

  19. Final report on EURAMET.M.P-K4.2010: Key and supplementary comparison of national pressure standards in the range 1 Pa to 15 kPa of absolute and gauge pressure

    NASA Astrophysics Data System (ADS)

    Krajíček, Zdeněk; Bergoglio, Mercede; Jousten, Karl; Otal, Pierre; Sabuga, Wladimir; Saxholm, Sari; Pražák, Dominik; Vičar, Martin

    2014-01-01

    This report describes a EURAMET comparison of five European National Metrology Institutes in low gauge and absolute pressure in gas (nitrogen), denoted as EURAMET.M.P-K4.2010. Its main intention is to state equivalence of the pressure standards, in particular those based on the technology of force-balanced piston gauges such as e.g. FRS by Furness Controls, UK and FPG8601 by DHI-Fluke, USA. It covers the range from 1 Pa to 15 kPa, both gauge and absolute. The comparison in absolute mode serves as a EURAMET Key Comparison which can be linked to CCM.P-K4 and CCM.P-K2 via PTB. The comparison in gauge mode is a supplementary comparison. The comparison was carried out from September 2008 till October 2012. The participating laboratories were the following: CMI, INRIM, LNE, MIKES, PTB-Berlin (absolute pressure 1 kPa and below) and PTB-Braunschweig (absolute pressure 1 kPa and above and gauge pressure). CMI was the pilot laboratory and provided a transfer standard for the comparison. This transfer standard was also the laboratory standard of CMI at the same time, which resulted in a unique and logistically difficult star comparison. Both in gauge and absolute pressures all the participating institutes successfully proved their equivalence with respect to the reference value and all also proved mutual bilateral equivalences in all the points. All the participating laboratories are also equivalent with the reference values of CCM.P-K4 and CCM.P-K2 in the relevant points. The comparison also proved the ability of FPG8601 to serve as a transfer standard. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

  20. Geostatistical modeling of the gas emission zone and its in-place gas content for Pittsburgh-seam mines using sequential Gaussian simulation

    USGS Publications Warehouse

    Karacan, C.O.; Olea, R.A.; Goodman, G.

    2012-01-01

    Determination of the size of the gas emission zone, the locations of gas sources within, and especially the amount of gas retained in those zones is one of the most important steps for designing a successful methane control strategy and an efficient ventilation system in longwall coal mining. The formation of the gas emission zone and the potential amount of gas-in-place (GIP) that might be available for migration into a mine are factors of local geology and rock properties that usually show spatial variability in continuity and may also show geometric anisotropy. Geostatistical methods are used here for modeling and prediction of gas amounts and for assessing their associated uncertainty in gas emission zones of longwall mines for methane control.This study used core data obtained from 276 vertical exploration boreholes drilled from the surface to the bottom of the Pittsburgh coal seam in a mining district in the Northern Appalachian basin. After identifying important coal and non-coal layers for the gas emission zone, univariate statistical and semivariogram analyses were conducted for data from different formations to define the distribution and continuity of various attributes. Sequential simulations performed stochastic assessment of these attributes, such as gas content, strata thickness, and strata displacement. These analyses were followed by calculations of gas-in-place and their uncertainties in the Pittsburgh seam caved zone and fractured zone of longwall mines in this mining district. Grid blanking was used to isolate the volume over the actual panels from the entire modeled district and to calculate gas amounts that were directly related to the emissions in longwall mines.Results indicated that gas-in-place in the Pittsburgh seam, in the caved zone and in the fractured zone, as well as displacements in major rock units, showed spatial correlations that could be modeled and estimated using geostatistical methods. This study showed that GIP volumes may

  1. HAER PA,48BETH,10 (sheet 5 of 5) Luckenbach Flour Mill, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    HAER PA,48-BETH,10- (sheet 5 of 5) - Luckenbach Flour Mill, 250 feet east of Monocacy Creek, 250 feet west of Main Street, 700 feet south of Broad Street, north side of Ohio Road, Bethlehem, Northampton County, PA

  2. HAER PA,48BETH,10 (sheet 2 of 5) Luckenbach Flour Mill, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    HAER PA,48-BETH,10- (sheet 2 of 5) - Luckenbach Flour Mill, 250 feet east of Monocacy Creek, 250 feet west of Main Street, 700 feet south of Broad Street, north side of Ohio Road, Bethlehem, Northampton County, PA

  3. HAER PA,48BETH,10 (sheet 1 of 5) Luckenbach Flour Mill, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    HAER PA,48-BETH,10- (sheet 1 of 5) - Luckenbach Flour Mill, 250 feet east of Monocacy Creek, 250 feet west of Main Street, 700 feet south of Broad Street, north side of Ohio Road, Bethlehem, Northampton County, PA

  4. HAER PA,48BETH,10 (sheet 4 of 5) Luckenbach Flour Mill, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    HAER PA,48-BETH,10- (sheet 4 of 5) - Luckenbach Flour Mill, 250 feet east of Monocacy Creek, 250 feet west of Main Street, 700 feet south of Broad Street, north side of Ohio Road, Bethlehem, Northampton County, PA

  5. HAER PA,48BETH,10 (sheet 3 of 5) Luckenbach Flour Mill, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    HAER PA,48-BETH,10- (sheet 3 of 5) - Luckenbach Flour Mill, 250 feet east of Monocacy Creek, 250 feet west of Main Street, 700 feet south of Broad Street, north side of Ohio Road, Bethlehem, Northampton County, PA

  6. WEST ELEVATION, ARCADE. Glass plate stereopair number PA1430139 LCHABSGS05W2 157.4660. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    WEST ELEVATION, ARCADE. Glass plate stereopair number PA-1430-139 LC-HABS-GS05-W-2 157.4660. Right (not printed) - Independence Hall Complex, Independence Hall, 500 Chestnut Street, Philadelphia, Philadelphia County, PA

  7. HAER PA,35SCRAN,4F (sheet 1 of 1) Delaware, Lackawanna & ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    HAER PA,35-SCRAN,4-F- (sheet 1 of 1) - Delaware, Lackawanna & Western Railroad, Scranton Yards, Scrap Platform, 350 feet South of South Washington Avenue & River Street, Scranton, Lackawanna County, PA

  8. 11. Pennsylvania Railroad: 30th Street Station. Philadelphia, Philadelphia Co., PA. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. Pennsylvania Railroad: 30th Street Station. Philadelphia, Philadelphia Co., PA. Sec. 1101, MP 88.10. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  9. 10. Pennsylvania Railroad: 30th Street Station. Philadelphia, Philadelphia Co., PA. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. Pennsylvania Railroad: 30th Street Station. Philadelphia, Philadelphia Co., PA. Sec. 1101, MP 88.10. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  10. 9. Pennsylvania Railroad: 30th Street Station. Philadelphia, Philadelphia Co., PA. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. Pennsylvania Railroad: 30th Street Station. Philadelphia, Philadelphia Co., PA. Sec. 1101, MP 88.10. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  11. Ammonia sensing behaviors of TiO2-PANI/PA6 composite nanofibers.

    PubMed

    Wang, Qingqing; Dong, Xianjun; Pang, Zengyuan; Du, Yuanzhi; Xia, Xin; Wei, Qufu; Huang, Fenglin

    2012-01-01

    Titanium dioxide-polyaniline/polyamide 6 (TiO(2)-PANI/PA6) composite nanofibers were prepared by in situ polymerization of aniline in the presence of PA6 nanofibers and a sputtering-deposition process with a high purity titanium sputtering target. TiO(2)-PANI/PA6 composite nanofibers and PANI/PA6 composite nanofibers were fabricated for ammonia gas sensing. The ammonia sensing behaviors of the sensors were examined at room temperature. All the results indicated that the ammonia sensing property of TiO(2)-PANI/PA6 composite nanofibers was superior to that of PANI/PA6 composite nanofibers. TiO(2)-PANI/PA6 composite nanofibers had good selectivity to ammonia. It was also found that the content of TiO(2) had a great influence on both the morphology and the sensing property of TiO(2)-PANI/PA6 composite nanofibers. PMID:23235446

  12. SOUTH ELEVATION, TOWER, UPPER LEFT. Glass plate stereopair number PA1430139 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    SOUTH ELEVATION, TOWER, UPPER LEFT. Glass plate stereopair number PA-1430-139 LC-HABS-GS05-ST-5 157.4651. Left (printed) - Independence Hall Complex, Independence Hall, 500 Chestnut Street, Philadelphia, Philadelphia County, PA

  13. SOUTH ELEVATION, TOWER, UPPER LEFT. Glass plate stereopair number PA1430139 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    SOUTH ELEVATION, TOWER, UPPER LEFT. Glass plate stereopair number PA-1430-139 LC-HABS-GS05-ST-5 157.4651. Right (not printed) - Independence Hall Complex, Independence Hall, 500 Chestnut Street, Philadelphia, Philadelphia County, PA

  14. Color fluctuations in pA collisions at collider energies

    NASA Astrophysics Data System (ADS)

    Strikman, Mark

    2015-04-01

    In pA collisions at collider energies a projectile stays in a frozen configuration over the distances which by far exceed the nuclear diameter. As a result proton coherently interacts with nucleons along its impact parameter. In QCD nucleon is build of configurations of different transverse size which are expected to interact with different strength leading to the fluctuations of the global strength of the projectile interaction. Also, configurations of smaller size are expected to have a reduced gluon field leading to a correlation of soft and hard interactions. The shape of the distribution over the strength of interaction is strongly constrained by the diffractive pp data, behavior of the distribution for σ --> 0 expected in pQCD, etc. We developed a Monte Carlo procedure for taking into account these effects in soft collisions and collisions with a hard trigger taking into account difference of the transverse scales of hard and soft interactions. We predicted that distribution over the number of wounded nucleons should be broader than in the Glauber model in agreement with the recent LHC data. We argue that a strong violation of the Glauber approximation in the dependence of the rate of forward jet production on centrality observed in pA collisions at the LHC provides the first experimental evidence that parton configurations in the projectile proton containing a parton with large xp interact with a nuclei with a significantly smaller than average cross section and have smaller than average size. Implementing effects of the interaction strength fluctuations and using the ATLAS analysis of the dependence of the hadron production at backward rapidities on the number of wounded nucleons, we make quantitative predictions for the centrality dependence of the jet production rate as a function of the interaction strength σ(xp) . We find σ(xp = 0.6) ~σtot(pp)/2 which sheds light on the origin of the EMC effect. Future pA dijet studies along these lines would allow

  15. 23 CFR Appendix F to Part 1200 - Planning and Administration (P&A) Costs

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 23 Highways 1 2014-04-01 2014-04-01 false Planning and Administration (P&A) Costs F Appendix F to... HIGHWAY SAFETY GRANT PROGRAMS Pt. 1200, App. F Appendix F to Part 1200—Planning and Administration (P&A) Costs (a) Policy. Federal participation in P&A activities shall not exceed 50 percent of the total...

  16. 23 CFR Appendix F to Part 1200 - PLANNING AND ADMINISTRATION (P&A) COSTS

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 23 Highways 1 2013-04-01 2013-04-01 false PLANNING AND ADMINISTRATION (P&A) COSTS F APPENDIX F TO... HIGHWAY SAFETY GRANT PROGRAMS Pt. 1200, App. F APPENDIX F TO PART 1200—PLANNING AND ADMINISTRATION (P&A) COSTS (a) Policy. Federal participation in P&A activities shall not exceed 50 percent of the total...

  17. A Study of the Presence of Gunshot Residue in Pittsburgh Police Stations using SEM/EDS and LC-MS/MS.

    PubMed

    Ali, Leah; Brown, Kyle; Castellano, Holly; Wetzel, Stephanie J

    2016-07-01

    Due to possible secondary transfer of gunshot residue (GSR) onto a suspect in police custody prior to sampling, a baseline must be created for the amount of GSR present. With an increase of "lead free" ammunition, testing for both gunpowder and primer GSR is relevant. Seventy samples were collected using carbon-coated adhesive stubs from four Pittsburgh Police Stations and vehicles to investigate these locations as sources of secondary GSR contamination. These seventy samples were analyzed for primer GSR using scanning electron microscopy-energy-dispersive X-ray spectrometry. One primer GSR particle was detected; no sample was classified as positive for primer GSR. These same samples were then analyzed for gunpowder GSR using liquid chromatography coupled to tandem mass spectrometry to test for akardite II, ethylcentralite, diphenylamine, N-nitrosodiphenylamine, 2-nitrodiphenylamine, and 4-nitrodiphenylamine. Ethylcentralite was quantifiable in two test samples. These results suggest there is a negligible potential for secondary transfer of primer and gunpowder GSR. PMID:27364271

  18. In silico design of smart binders to anthrax PA

    NASA Astrophysics Data System (ADS)

    Sellers, Michael; Hurley, Margaret M.

    2012-06-01

    The development of smart peptide binders requires an understanding of the fundamental mechanisms of recognition which has remained an elusive grail of the research community for decades. Recent advances in automated discovery and synthetic library science provide a wealth of information to probe fundamental details of binding and facilitate the development of improved models for a priori prediction of affinity and specificity. Here we present the modeling portion of an iterative experimental/computational study to produce high affinity peptide binders to the Protective Antigen (PA) of Bacillus anthracis. The result is a general usage, HPC-oriented, python-based toolkit based upon powerful third-party freeware, which is designed to provide a better understanding of peptide-protein interactions and ultimately predict and measure new smart peptide binder candidates. We present an improved simulation protocol with flexible peptide docking to the Anthrax Protective Antigen, reported within the context of experimental data presented in a companion work.

  19. CosPA 2015 and the Standard Model

    NASA Astrophysics Data System (ADS)

    Pauchy Hwang, W.-Y.

    2016-07-01

    In this keynote speech, I describe briefly “The Universe”, a journal/newsletter launched by APCosPA Organization, and my lifetime research on the Standard Model of particle physics. In this 21st Century, we should declare that we live in the quantum 4-dimensional Minkowski space-time with the force-fields gauge-group structure SUc(3) × SUL(2) × U(1) × SUf(3) built-in from the very beginning. This background can see the lepton world, of atomic sizes, and offers us the eyes to see other things. It also can see the quark world, of the Fermi sizes, and this fact makes this entire world much more interesting.

  20. Evaluation of the CMB and PMF models using organic molecular markers in fine particulate matter collected during the Pittsburgh Air Quality Study

    NASA Astrophysics Data System (ADS)

    Bullock, Kerry R.; Duvall, Rachelle M.; Norris, Gary A.; McDow, Stephen R.; Hays, Michael D.

    This analysis investigated different possible strategies for source apportionment of airborne fine particulate matter (PM 2.5) using data collected as part of the Pittsburgh Air Quality Study (PAQS). More specifically, we apportioned the organic fraction of the winter and summer season PM 2.5 using two source-receptor models - the EPA Chemical Mass Balance 8.2 (CMB) and EPA Positive Matrix Factorization 1.1 (PMF) models - and tested several case scenarios with each model by varying either the chemical species or source profiles used as model input. Moreover, we added the constraint of selecting only individual molecular marker species with concentrations above their minimum quantitative limits. Model results suggest that the molecular marker and source profile selection can strongly affect the model, as reflected in the source contribution estimates determined by both CMB and PMF. Biomass burning and mobile emissions sources were identified by both models as being major source contributors in Pittsburgh. A third source was consistent with a meat cooking profile but was more likely a combination of cooking and secondary organic aerosol. As expected, the relative proportion of each source's contribution depended on both the season and on whether the CMB or PMF model was applied. Selecting fewer species in CMB resulted in less mass being apportioned, and an unrealistically large wood burning contribution estimate. Swapping a wildfire profile for one of the two wood burning profiles also resulted in less mass being apportioned in the winter. The results suggest that CMB can distinguish between fireplace burning and wildfire contributions when appropriate species are included. The gasoline/diesel split also varied by up to an order of magnitude, depending on which model was applied and which species were fit.

  1. Insights into the primary-secondary and regional-local contributions to organic aerosol and PM 2.5 mass in Pittsburgh, Pennsylvania

    NASA Astrophysics Data System (ADS)

    Subramanian, R.; Donahue, Neil M.; Bernardo-Bricker, Anna; Rogge, Wolfgang F.; Robinson, Allen L.

    This paper presents chemical mass balance (CMB) analysis of organic molecular marker data to investigate the sources of organic aerosol and PM 2.5 mass in Pittsburgh, Pennsylvania. The model accounts for emissions from eight primary source classes, including major anthropogenic sources such as motor vehicles, cooking, and biomass combustion as well as some primary biogenic emissions (leaf abrasion products). We consider uncertainty associated with selection of source profiles, selection of fitting species, sampling artifacts, photochemical aging, and unknown sources. In the context of the overall organic carbon (OC) mass balance, the contributions of diesel, wood-smoke, vegetative detritus, road dust, and coke-oven emissions are all small and well constrained; however, estimates for the contributions of gasoline-vehicle and cooking emissions can vary by an order of magnitude. A best-estimate solution is presented that represents the vast majority of our CMB results; it indicates that primary OC only contributes 27±8% and 50±14% (average±standard deviation of daily estimates) of the ambient OC in the summer and winter, respectively. Approximately two-thirds of the primary OC is transported into Pittsburgh as part of the regional air mass. The ambient OC that is not apportioned by the CMB model is well correlated with secondary organic aerosol (SOA) estimates based on the EC-tracer method and ambient concentrations of organic species associated with SOA. Therefore, SOA appears to be the major component of OC, not only in summer, but potentially in all seasons. Primary OC dominates the OC mass balance on a small number of nonsummer days with high OC concentrations; these events are associated with specific meteorological conditions such as local inversions. Primary particulate emissions only contribute a small fraction of the ambient fine-particle mass, especially in the summer.

  2. Apportionment of ambient primary and secondary fine particulate matter during a 2001 summer intensive study at the CMU Supersite and NETL Pittsburgh Site

    SciTech Connect

    Delbert J. Eatough; Nolan F. Mangelson; Richard R. Anderson

    2007-10-15

    Gaseous and particulate pollutant concentrations associated with five samples per day collected during a July 2001 summer intensive study at the Pittsburgh Carnegie Mellon University (CMU) Supersite were used to apportion fine particulate matter (PM2.5) into primary and secondary contributions using PMF2. Input to the PMF2 analysis included the concentrations of PM2.5 nonvolatile and semivolatile organic material, elemental carbon (EC), ammonium sulfate, trace element components, gas-phase organic material, and NOx, NO{sub 2}, and O{sub 3} concentrations. A total of 10 factors were identified. These factors are associated with emissions from various sources and facilities including crustal material, gasoline combustion, diesel combustion, and three nearby sources high in trace metals. In addition, four secondary sources were identified, three of which were associated with secondary products of local emissions and were dominated by organic material and one of which was dominated by secondary ammonium sulfate transported to the CMU site from the west and southwest. The three largest contributors to PM2.5 were secondary transported material (dominated by ammonium sulfate) from the west and southwest from sources including coal-fired power plants, coke processing plants and steel mills, (49%), secondary material formed during midday photochemical processes (24%), and gasoline combustion emissions (11%). The other seven sources accounted for the remaining 16% of the PM2.5. Results obtained at the CMU site were comparable to results previously reported at the National Energy Technology Laboratory (NETL), located approximately 18 km south of downtown Pittsburgh. The major contributor at both sites was material transported from the west and southwest. Some difference in nearby sources could be attributed to meteorology as evaluated by HYSPLIT model back-trajectory calculations. 27 refs., 16 figs., 1 tab.

  3. The Western USA Heat Waves of the Current Decade as Modeled by WRF

    NASA Astrophysics Data System (ADS)

    Habtezion, B. L.; Diffenbaugh, N. S.

    2012-12-01

    Heat waves are common in the USA and are the causes of significant weather related deaths. Previous research has shown that strong subtropical ridges and anticyclones characterize the heat waves in the United States and sever heat waves had been generally associated with ridges over the oceans. The complex topographic and thermal structure of the western USA could also further complicate the dynamics that initiate and control the development of the heat wave. Analysis of July 2003 and 2007 North American Regional Reanalysis (NARR) three hourly 500 hPa geopotential height anomalies with a base line climatology period of 1979-2010 showed an initiation of strong low level southerly flow which was greatly enhanced by the west-east pressure gradient between the abnormal low pressure over the Pacific Northwest and abnormally high pressure over the Northwest, which resulted in heat waves over the northwest. Analysis of temperature and moisture fields from Weather Research and Forecast Model (WRF) for the summer (JJA) 2001-2010 at resolutions of 4km, covering the entire Western USA will be presented. Analysis of subsidence inversion and surface feedbacks will also be carried out to study the development and continuity of the low level heat. The hourly heat indices, which will be a measure of the heat stresses, will be calculated and compared for each year in the simulation period. Results will help in better understand the initiation and development of the heat waves and future predictions of catastrophic heat waves over this region.

  4. Tribological properties of PTFE filled plants-derived semi-aromatic polyamide (PA10T) and GF reinforced PTFE/PA10T composites

    NASA Astrophysics Data System (ADS)

    Takenaka, Yuki; Nishitani, Yosuke; Kitano, Takeshi

    2015-05-01

    For the purpose of developing the new engineering materials such as structural materials and tribomaterials based on plants-derived polymers, the tribological properties of polytetrafluoroethylene (PTFE) filled plants-derived semi-aromatic polyamide 10T (PA10T) composites and glass fiber (GF) reinforced PTFE/PA10T composites were investigated. PA10T is a kind of polyphthalamide (PPA, semi-aromatic polyamide) and biomass polymer made from plants-derived decamethylenediamine and coal-derived terephthalic acid. PTFE/PA10T and GF/PA10T/PTFE composites were melt-mixed by a twin screw extruder and injection-molded. Their mechanical properties such as tensile, Izod impact, and tribological properties were evaluated. Tribological properties were measured by a ring-on-plate type sliding wear tester under dry condition. Tribological properties of PA10T such as frictional coefficient, specific wear rate and limiting pv value improved with the addition of PTFE, although the mechanical properties such as tensile strength and tensile modulus decreased with PTFE. On the other hand, the frictional coefficient and specific wear rate of GF/PA10T/PTFE composites were higher than those of PTFE/PA10T composites, however limiting pv value and mechanical properties improved significantly with the filling of GF. It follows from these results that it may be possible to develop the new tribomaterials based on plants-derived polymer composites with sufficient balances between mechanical and tribological properties.

  5. PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse.

    PubMed

    Peeters, H; Debeer, P; Bairoch, A; Wilquet, V; Huysmans, C; Parthoens, E; Fryns, J P; Gewillig, M; Nakamura, Y; Niikawa, N; Van de Ven, W; Devriendt, K

    2003-05-01

    Heterotaxia is an aetiologically heterogeneous condition caused by an abnormal left-right axis formation, resulting in reversed left-right polarity of one or more organ systems. In a patient with heterotaxia and a de novo reciprocal translocation t(6;18)(q21;q21), we found that the PA26 gene was disrupted by the 6q21 breakpoint. Northern blot analysis showed decreased expression of the PA26 gene in an Epstein-Barr virus-transformed cell line of this patient. During early embryogenesis of Xenopus, the orthologue of PA26, XPA26 is exclusively expressed in the notochord, a midline structure. This further supports a possible role of PA26 in human situs determination. Mutation analysis of human PA26 gene in 40 unrelated individuals with unexplained heterotaxia failed to identify mutations, indicating that PA26 mutations are not a frequent cause of heterotaxia in humans. Analysis of the PA26 gene structure resulted in the identification of a novel PA26-related gene family, which we have named the sestrin family, and which comprises three closely related genes in human and in mouse. PMID:12607115

  6. Agricultural Virtual Water Flows in the USA

    NASA Astrophysics Data System (ADS)

    Konar, M.; Dang, Q.; Lin, X.

    2014-12-01

    Global virtual water trade is an important research topic that has yielded several interesting insights. In this paper, we present a comprehensive assessment of virtual water flows within the USA, a country with global importance as a major agricultural producer and trade power. This is the first study of domestic virtual water flows based upon intra-national food flow data and it provides insight into how the properties of virtual water flows vary across scales. We find that both the value and volume of food flows within the USA are roughly equivalent to half that of international flows. However, USA food flows are more water intensive than international food trade, due to the higher fraction of water-intensive meat trade within the USA. The USA virtual water flow network is more social, homogeneous, and equitable than the global virtual water trade network, although it is still not perfectly equitable. Importantly, a core group of U.S. States is central to the network structure, indicating that both domestic and international trade may be vulnerable to disruptive climate or economic shocks in these U.S. States.

  7. Strategies for improved rhamnolipid production by Pseudomonas aeruginosa PA1

    PubMed Central

    Pereira Jr, Nei; Freire, Denise M.G.

    2016-01-01

    Rhamnolipids are biosurfactants with potential for diversified industrial and environmental uses. The present study evaluated three strategies for increasing the production of rhamnolipid-type biosurfactants produced by Pseudomonas aeruginosa strain PA1. The influence of pH, the addition of P. aeruginosa spent culture medium and the use of a fed-batch process were examined. The culture medium adjusted to pH 7.0 was the most productive. Furthermore, the pH of the culture medium had a measurable effect on the ratio of synthesized mono- and dirhamnolipids. At pH values below 7.3, the proportion of monorhamnolipids decreased from 45 to 24%. The recycling of 20% of the spent culture medium in where P. aeruginosa was grown up to the later stationary phase was responsible for a 100% increase in rhamnolipid volumetric productivity in the new culture medium. Finally, the use of fed-batch operation under conditions of limited nitrogen resulted in a 3.8-fold increase in the amount of rhamnolipids produced (2.9 g L−1–10.9 g L−1). These results offer promising pathways for the optimization of processes for the production of rhamnolipids. PMID:27257553

  8. Range and railgun development results at LS and PA ``Soyuz``

    SciTech Connect

    Babakov, Y.P.; Plekhanov, A.V.; Zheleznyi, V.B.

    1995-01-01

    A rail electromagnetic accelerator is one of the most reliable and simple devices for accelerating macroparticles up to high velocity. These accelerators allow scientists to carry out fundamental and applied investigations to study both equation-of-state of materials at high pressure due to high velocity encounters, and creation of conditions for shock thermonuclear fusion. In the department ``Energophyzika`` LS and PA ``Soyuz`` range was created. It was equipped with an inductor with storage capacity up to 12.5 MJ energized by a solid propellant MHD generator and a capacitor bank (energy capacity up to 6 MJ). These systems deliver currents of 1 MA and 2 MA, respectively. Diagnostic, recording, and autocalculation systems allow use of as many as 120 data channels with acquisition frequency up to 10 MHz. Recent technical successes in railgun construction, using special methods to compact plasma armature and produce high velocity trailing contact, creation of hybrid armatures, and optimizing acceleration made possible to gain velocities in the range of 6.2 to 6.8 km/s (masses of 3.8 to 10 g) and velocities 2.7 to 3.8 km/s (masses of 50 to 100 g) on railguns with length 2 to 4 m.

  9. t-PA activity in peripheral blood obtained from pregnant women.

    PubMed

    Ishii, A; Yamada, S; Yamada, R; Hamada, H

    1994-01-01

    Concentrations of tissue plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI) were measured in blood obtained from pregnant women to elucidate the fluctuations in the fibrinolytic system which occur during the course of pregnancy. The t-PA activity was measured with a modified bioimmunoassay using anti-t-PA monoclonal antibody (SP-322) against a single chain of recombinant t-PA. The t-PA antigen was measured by ELISA using the same antibody. PAI activity was determined with a competitive inhibition assay of t-PA activity. In early pregnancy, t-PA activity was found to be close to the standard range seen in nonpregnant women, and gradually decreased during the course of pregnancy, then recovered to rise to the normal range within 48 hours after delivery. The t-PA antigen and PAI activity levels rose slowly during the course of pregnancy, and fell promptly after delivery. t-PA activity and t-PA antigen in levels in umbilical cord blood were higher after vaginal delivery than after cesarean section. These findings suggest that there may be an important physiological balance of the fibrinolytic system between mother and fetus during the course of pregnancy and the puerperium. PMID:7965540

  10. Crystal structure of an avian influenza polymerase PA[subscript N] reveals an endonuclease active site

    SciTech Connect

    Yuan, Puwei; Bartlam, Mark; Lou, Zhiyong; Chen, Shoudeng; Zhou, Jie; He, Xiaojing; Lv, Zongyang; Ge, Ruowen; Li, Xuemei; Deng, Tao; Fodor, Ervin; Rao, Zihe; Liu, Yingfang

    2009-11-10

    The heterotrimeric influenza virus polymerase, containing the PA, PB1 and PB2 proteins, catalyses viral RNA replication and transcription in the nucleus of infected cells. PB1 holds the polymerase active site and reportedly harbours endonuclease activity, whereas PB2 is responsible for cap binding. The PA amino terminus is understood to be the major functional part of the PA protein and has been implicated in several roles, including endonuclease and protease activities as well as viral RNA/complementary RNA promoter binding. Here we report the 2.2 angstrom (A) crystal structure of the N-terminal 197 residues of PA, termed PA(N), from an avian influenza H5N1 virus. The PA(N) structure has an alpha/beta architecture and reveals a bound magnesium ion coordinated by a motif similar to the (P)DX(N)(D/E)XK motif characteristic of many endonucleases. Structural comparisons and mutagenesis analysis of the motif identified in PA(N) provide further evidence that PA(N) holds an endonuclease active site. Furthermore, functional analysis with in vivo ribonucleoprotein reconstitution and direct in vitro endonuclease assays strongly suggest that PA(N) holds the endonuclease active site and has critical roles in endonuclease activity of the influenza virus polymerase, rather than PB1. The high conservation of this endonuclease active site among influenza strains indicates that PA(N) is an important target for the design of new anti-influenza therapeutics.

  11. Complete Genome Sequence of the Multiresistant Taxonomic Outlier Pseudomonas aeruginosa PA7

    PubMed Central

    Roy, Paul H.; Tetu, Sasha G.; Larouche, André; Elbourne, Liam; Tremblay, Simon; Ren, Qinghu; Dodson, Robert; Harkins, Derek; Shay, Ryan; Watkins, Kisha; Mahamoud, Yasmin; Paulsen, Ian T.

    2010-01-01

    Pseudomonas aeruginosa PA7 is a non-respiratory human isolate from Argentina that is multiresistant to antibiotics. We first sequenced gyrA, gyrB, parC, parE, ampC, ampR, and several housekeeping genes and found that PA7 is a taxonomic outlier. We report here the complete sequence of the 6,588,339 bp genome, which has only about 95% overall identity to other strains. PA7 has multiple novel genomic islands and a total of 51 occupied regions of genomic plasticity. These islands include antibiotic resistance genes, parts of transposons, prophages, and a pKLC102-related island. Several PA7 genes not present in PAO1 or PA14 are putative orthologues of other Pseudomonas spp. and Ralstonia spp. genes. PA7 appears to be closely related to the known taxonomic outlier DSM1128 (ATCC9027). PA7 lacks several virulence factors, notably the entire TTSS region corresponding to PA1690-PA1725 of PAO1. It has neither exoS nor exoU and lacks toxA, exoT, and exoY. PA7 is serotype O12 and pyoverdin type II. Preliminary proteomic studies indicate numerous differences with PAO1, some of which are probably a consequence of a frameshift mutation in the mvfR quorum sensing regulatory gene. PMID:20107499

  12. Effect of Low Frequency Ultrasound on Combined rt-PA and Eptifibatide Thrombolysis in Human Clots

    PubMed Central

    Meunier, Jason M.; Holland, Christy K.; Pancioli, Arthur M.; Lindsell, Christopher J.; Shaw, George J.

    2009-01-01

    Introduction Fibrinolytics such as recombinant tissue plasminogen activator (rt-PA) are used to treat thrombotic disease such as acute myocardial infarction (AMI) and ischemic stroke. Interest in increasing efficacy and reducing side effects has led to the study of adjuncts such as GP IIb-IIIa inhibitors and ultrasound (US) enhanced thrombolysis. Currently, GP IIb-IIIa inhibitor and fibrinolytic treatment are often used in AMI, and are under investigation for stroke treatment. However, little is known of the efficacy of combined GP IIb-IIIa inhibitor, fibrinolytic and ultrasound treatment. We measure the lytic efficacy of rt-PA, eptifibatide (Epf) and 120 kHz ultrasound treatment in an in-vitro human clot model. Materials and Methods Blood was drawn from 15 subjects after IRB approval. Clots were made in 20 μL pipettes, and placed in a water tank for microscopic visualization during lytic treatment. Clots were exposed to control, rt-PA (rt-PA), eptifibatide (Epf), or rt-PA+eptifibatide (rt-PA+Epf), with or without ultrasound for 30 minutes at 37°C in human plasma. Clot lysis was measured over time, using a microscopic imaging technique. The fractional clot loss (FCL) and initial lytic rate (LR) were used to quantify lytic efficacy. Results and Conclusions LR values for (−US) treated clots were 0.8±0.1(control), 1.8±0.3 (Epf), 1.5±0.2 (rt-PA), and 1.3±0.4 (rt-PA+Epf) (% clot width/minute) respectively. In comparison, the (+US) group exhibited LR values of 1.6±0.2 (control), 4.3±0.4 (Epf), 6.3±0.4 (rt-PA), and 4.6±0.6 (rt-PA+Epf). For (−US) treated clots, FCL was 6.0±0.8 (control), 9.2±2.5 (Epf), 15.6±1.7 (rt-PA), and 28.0±2.2% (rt-PA+Epf) respectively. FCL for (+US) clots was 13.5±2.4 (control), 20.7±6.4 (Epf), 44.4±3.6 (rt-PA) and 30.3±3.6% (rt-PA+Epf) respectively. Although the addition of eptifibatide enhances the in-vitro lytic efficacy of rt-PA in the absence of ultrasound, the efficacy of ultrasound and rt-PA is greater than that of

  13. Conference report: Clinical and Pharmaceutical Solutions through analysis (CPSA USA 2013): connecting patients and subject numbers through analysis.

    PubMed

    Needham, Shane; Premkumar, Noel; Weng, Naidong; Lee, Mike

    2014-02-01

    The 16th Annual Symposium on Clinical and Pharmaceutical Solutions through Analysis (CPSA) 7-10 October 2013, Sheraton Bucks County Hotel, Langhorne, PA, USA. The 2013 CPSA brought together the various US FDA regulated analytical fields affecting a 'patient' for the first time - bioanalysts supporting IND and NDAs, clinical diagnostic and pathology laboratory personnel, and clinical researchers that provide insights into new biomarkers. Although the regulatory requirements are different for each of the above disciplines, the unique analytical perspectives that affect the patient were shared - and the goal of the 2013 CPSA - 'Connecting Patients and Subject Numbers Through Analysis' was achieved. PMID:24471949

  14. Low-Temperature Curable Photo-Active Anisotropic Conductive Films (PA-ACFs)

    NASA Astrophysics Data System (ADS)

    Kim, Il; Paik, Kyung-Wook

    2014-09-01

    Photo-active anisotropic conductive films (PA-ACFs) with curing temperatures below 120°C were introduced using photo-active curing agents. The PA-ACFs showed no curing before UV activation, and the crosslinking systems of the PA-ACFs were not activated under fluorescent light exposure. However, after UV activation, the PA-ACFs were completely cured at 120°C within 10 s. Flex-on-board (FOB) assembly using PA-ACFs had adhesion strength and joint resistances similar to those of the FOB assemblies using conventional epoxy-based ACFs. This study demonstrates that PA-ACFs provide reliable interconnection and minimal thermal deformation among all the commercially available ACFs, especially for low T g substrate applications.

  15. Plutonium contamination in soils and sediments at Mayak PA, Russia.

    PubMed

    Skipperud, Lindis; Salbu, Brit; Oughton, Deborah H; Drozcho, Eugeny; Mokrov, Yuri; Strand, Per

    2005-09-01

    The Mayak Production Association (Mayak PA) was established in the late 1940's to produce plutonium for the Soviet Nuclear Weapons Programme. In total, seven reactors and two reprocessing plants have been in operation. Today, the area comprises both military and civilian reactors as well as reprocessing and metallurgical plants. Authorized and accidental releases of radioactive waste have caused severe contamination to the surrounding areas. In the present study, [alpha]-spectrometry and inductively coupled plasma-mass spectrometry (ICP-MS) have been used to determine plutonium activities and isotope ratios in soil and sediment samples collected from reservoirs of the Techa River at the Mayak area and downstream Techa River. The objective of the study was to determine the total inventory of plutonium in the reservoirs and to identify the different sources contributing to the plutonium contamination. Results based on [alpha]-spectrometry and ICP-MS measurements show the presence of different sources and confirmed recent reports of civilian reprocessing at Mayak. Determination of activity levels and isotope ratios in soil and sediment samples from the Techa River support the hypothesis that most of the plutonium, like other radionuclides in the Techa River, originated from the very early waste discharges to the Techa River between 1949 and 1951. Analysis of reservoir sediment samples suggest that about 75% of the plutonium isotopes could have been released to Reservoir 10 during the early weapons production operation of the plant, and that the majority of plutonium in Reservoir 10 originates from discharges from power production or reprocessing. Enhanced 240Pu/239Pu atom ratios in river sediment upper layers (0-2 cm) between 50 and 250 km downstream from the plant indicate a contribution from other, non-fallout sources. PMID:16096501

  16. Preparation and properties of PA6/CSW composites via vane extruder

    NASA Astrophysics Data System (ADS)

    Haichen, Zhang; Jianbo, Li; Li, Yang; Guizhen, Zhang; Jinping, Qu

    2016-03-01

    The PA6/CSW composites were prepared with a vane extruder in this work, which is a novel polymer processing equipment dominated by elongational flow field. SEM microphotographs indicate that the whiskers were well dispersed in the polymer matrix under the elongational flow field of the vane extruder.The PA6/CSW composites were also characterized by DSC, Mechanical testing and Rheological measurements. The results show that the PA6/CSW composites have improved their tensile strength and modulus greatly.

  17. Dodecafluoropentane Emulsion Extends Window for tPA Therapy in a Rabbit Stroke Model

    PubMed Central

    Brown, A. T.; Lowery, J. D.; Arthur, M. C.; Roberson, P. K.; Skinner, R. D.

    2016-01-01

    Dodecafluoropentane emulsion (DDFPe) nanodroplets are exceptional oxygen transporters and can protect ischemic brain in stroke models 24 h without reperfusion. Current stroke therapy usually fails to reach patients because of delays following stroke onset. We tested using DDFPe to extend the time window for tissue plasminogen activator (tPA). Longer treatment windows will allow more patients more complete stroke recovery. We test DDFPe to safely extend the time window for tPA thrombolysis to 9 h after stroke. With IACUC approval, randomized New Zealand white rabbits (3.4–4.7 kg, n=30) received angiography and 4-mm blood clot in the internal carotid artery for flow-directed middle cerebral artery occlusion. Seven failed and were discarded. Groups were IV tPA (n=11), DDFPe + tPA (n=7), and no therapy controls (n=5). DDFPe (0.3 ml/kg, 2 % emulsion) IV dosing began at 1 h and continued at 90 min intervals for 6 doses in one test group; the other received saline injections. Both got standard IV tPA (0.9 mg/kg) therapy starting 9 h post stroke. At 24 h, neurological assessment scores (NAS, 0–18) were determined. Following brain removal percent stroke volume (%SV) was measured. Outcomes were compared with Kruskal-Wallis analysis. For NAS, DDFPe + tPA was improved overall, p=0.0015, and vs. tPA alone, p=0.0052. For %SV, DDFPe + tPA was improved overall, p=0.0003 and vs. tPA alone, p=0.0018. NAS controls and tPA alone were not different but %SV was, p=0.0078. With delayed reperfusion, DDFPe + tPAwas more effective than tPA alone in preserving functioning brain after stroke. DDFPe significantly extends the time window for tPA therapy. PMID:26055229

  18. Kids Voting USA: Bringing Out the Vote.

    ERIC Educational Resources Information Center

    Golston, Sydele E.

    1997-01-01

    Kids Voting USA is a grass roots, community-driven voter education program. A Kids Voting community must mobilize corporate sponsors, election officials, media representatives, and administrative staff to print curricula, train teachers, prepare students, welcome them to polling precincts, and count and report their votes. Children become…

  19. SWITCHGRASS FOR BIOMASS FEEDSTOCK IN THE USA

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Switchgrass (Panicum virgatum L.) has been identified as a model herbaceous energy crop for the USA. Intensive research on switchgrass as a biomass feedstock in the 1990s greatly improved our understanding of the adaptation of switchgrass cultivars, production practices, and environmental benefits. ...

  20. The Normalisation of Homeschooling in the USA

    ERIC Educational Resources Information Center

    Stevens, Mitchell L.

    2003-01-01

    Home education emerged as a deviant practice in the USA in the late 1970s and became an acceptable alternative to conventional schooling in a remarkably short period of time. This paper argues that the trajectory of normalisation has been shaped by cultural and institutional features peculiar to the US national context. The paper also offers…

  1. Powassan Meningoencephalitis, New York, New York, USA

    PubMed Central

    Wurcel, Alysse G.; Whittier, Susan; Kulas, Karen; Kramer, Laura D.; Flam, Robin; Roberts, James Kirkland; Tsiouris, Simon

    2013-01-01

    Disease caused by Powassan virus (POWV), a tick-borne flavivirus, ranges from asymptomatic to severe neurologic compromise and death. Two cases of POWV meningoencephalitis in New York, USA, highlight diagnostic techniques, neurologic outcomes, and the effect of POWV on communities to which it is endemic. PMID:23969017

  2. The USA PATRIOT Act: Archival Implications

    ERIC Educational Resources Information Center

    Trinkaus-Randall, Gregor

    2005-01-01

    In October 2001, Congress passed the USA PATRIOT Act to strengthen the ability of the U.S. government to combat terrorism. Unfortunately, some sections of the Act strike at core values and practices of libraries and archives, especially in the areas of record keeping, privacy, confidentiality, security, and access to the collections. This article…

  3. Modulation of Cellular Migration and Survival by c-Myc through the Downregulation of Urokinase (uPA) and uPA Receptor▿ †

    PubMed Central

    Alfano, Daniela; Votta, Giuseppina; Schulze, Almut; Downward, Julian; Caputi, Mario; Stoppelli, Maria Patrizia; Iaccarino, Ingram

    2010-01-01

    It has been proposed that c-Myc proapoptotic activity accounts for most of its restraint of tumor formation. We established a telomerase-immortalized human epithelial cell line expressing an activatable c-Myc protein. We found that c-Myc activation induces, in addition to increased sensitivity to apoptosis, reductions in cell motility and invasiveness. Transcriptome analysis revealed that urokinase (uPA) and uPA receptor (uPAR) were strongly downregulated by c-Myc. Evidence is provided that the repression of uPA and uPAR may account for most of the antimigratory and proapoptotic activities of c-Myc. c-Myc is known to cooperate with Ras in cellular transformation. We therefore investigated if this cooperation could converge in the control of uPA/uPAR expression. We found that Ras is able to block the effects of c-Myc activation on apoptosis and cellular motility but not on cell invasiveness. Accordingly, the activation of c-Myc in the context of Ras expression had only minor influence on uPAR expression but still had a profound repressive effect on uPA expression. Thus, the differential regulation of uPA and uPAR by c-Myc and Ras correlates with the effects of these two oncoproteins on cell motility, invasiveness, and survival. In conclusion, we have discovered a novel link between c-Myc and uPA/uPAR. We propose that reductions of cell motility and invasiveness could contribute to the inhibition of tumorigenesis by c-Myc and that the regulation of uPA and uPAR expression may be a component of the ability of c-Myc to reduce motility and invasiveness. PMID:20123981

  4. MemoPA: Intelligent Personal Assistant Agents with a Case Memory Mechanism

    NASA Astrophysics Data System (ADS)

    Chen, Ke-Jia; Barthès, Jean-Paul

    A Personal Assistant (PA) agent is a software agent capable of helping people to handle tasks in their workplace. The paper proposes a memory mechanism for personal assistant agents in order to enhance agent intelligence while working with the user or with other agents. Inspired by a case memory model in the domain of Case-Based Reasoning (CBR), this paper endows PA agents with a case memory mechanism, which results in improved PA agents: MemoPAs. We present the memory mechanism of MemoPA in detail, and report a first implementation of the method. Finally, future work is outlined for improving the memory mechanism.

  5. tPA promotes cortical neuron survival via mTOR-dependent mechanisms.

    PubMed

    Grummisch, Julia A; Jadavji, Nafisa M; Smith, Patrice D

    2016-07-01

    Tissue plasminogen activator (tPA) is a thrombolytic agent commonly used in the treatment of ischemic stroke. While the thrombolytic effects of tPA have been well established, the impact of this blood-brain barrier (BBB) crossing drug on neurons is not known. Given the widespread use of tPA in the clinical setting and the strict therapeutic window established for effective use of the drug, we examined the molecular mechanisms mediating the impact of tPA on postnatal cortical neurons isolated from the mouse brain. Dissociated postnatal primary cortical neurons were treated with tPA and the effects on neuron survival were evaluated. Pharmacological inhibitors of several signaling pathways previously implicated in neuroprotection (mTOR, JAK/STAT, MAPK and PKA-dependent mechanisms) were used to pinpoint the mechanistic effectors of tPA on neuron survival in vitro. We report here that tPA treatment results in a time-dependent neuroprotective effect on postnatal cortical neurons that relies predominantly on Janus kinase (JAK) and mammalian target of rapamycin (mTOR) signaling mechanisms. Taken together, these data suggest that tPA promotes neuroprotection in a temporally-regulated manner and that both JAK and mTOR signaling effectors are critical mediators of this neuroprotective effect. The results suggest the possibility of targeting these defined mechanisms to potentially expand the therapeutic window for tPA. PMID:26995507

  6. 75 FR 50774 - Towing Safety Advisory Committee; Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-17

    ... held at the Doubletree Hotel and Suites Pittsburgh City Center, One Bigelow Square, Pittsburgh, PA... Pittsburgh International Airport (PIT). Information on and directions to the Doubletree Hotel and Suites...

  7. VIEW FACING EAST. ORE TRESTLE WINDS AROUND THE INGOT MOLD ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW FACING EAST. ORE TRESTLE WINDS AROUND THE INGOT MOLD CONDITIONING BUILDING IN FOREGROUND. PITTSBURGH & LAKE ERIE TRACKS WIND THROUGH TOWN TOWARDS PITTSBURGH AT RIGHT. - Pittsburgh Steel Company, Monessen Works, Donner Avenue, Monessen, Westmoreland County, PA

  8. 78 FR 49270 - Information Collection; MyUSA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-13

    ..., and as detailed in the MyUSA System of Records Notice ( http://www.gpo.gov/fdsys/pkg/FR-2013-07-05/pdf... ADMINISTRATION Information Collection; MyUSA AGENCY: Office of Citizen Services and Innovative Technologies... request to review and approve a new information collection requirement regarding MyUSA. DATES:...

  9. Innovation and translation efforts in wireless medical connectivity, telemedicine and eMedicine: a story from the RFID Center of Excellence at the University of Pittsburgh.

    PubMed

    Sejdić, Ervin; Rothfuss, Michael A; Stachel, Joshua R; Franconi, Nicholas G; Bocan, Kara; Lovell, Michael R; Mickle, Marlin H

    2013-09-01

    Translational research has recently been rediscovered as one of the basic tenants of engineering. Although many people have numerous ideas of how to accomplish this successfully, the fundamental method is to provide an innovative and creative environment. The University of Pittsburgh has been accomplishing this goal though a variety of methodologies. The contents of this paper are exemplary of what can be achieved though the interaction of students, staff, faculty and, in one example, high school teachers. While the projects completed within the groups involved in this paper have spanned other areas, the focus of this paper is on the biomedical devices, that is, towards improving and maintaining health in a variety of areas. The spirit of the translational research is discovery, invention, intellectual property protection, and the creation of value through the spinning off of companies while providing better health care and creating jobs. All but one of these projects involve wireless radio frequency (RF) energy for delivery. The remaining device can be wirelessly connected for data collection. PMID:23897048

  10. Innovation and Translation Efforts in Wireless Medical Connectivity, Telemedicine and eMedicine: A Story from the RFID Center of Excellence at the University of Pittsburgh

    PubMed Central

    Sejdić, Ervin; Rothfuss, Michael; Stachel, Joshua R.; Franconi, Nicholas G.; Bocan, Kara; Lovell, Michael R.; Mickle, Marlin H.

    2016-01-01

    Translational research has recently been rediscovered as one of the basic tenants of engineering. Although many people have numerous ideas of how to accomplish this successfully, the fundamental method is to provide an innovative and creative environment. The University of Pittsburgh has been accomplishing this goal though a variety of methodologies. The contents of this paper are exemplary of what can be achieved though the interaction of students, staff, faculty and, in one example, high school teachers. While the projects completed within the groups involved in this paper have spanned other areas, the focus of this paper is on the biomedical devices, that is, towards improving and maintaining health in a variety of areas. The spirit of the translational research is discovery, invention, intellectual property protection, and the creation of value through the spinning off of companies while providing better health care and creating jobs. All but one of these projects involve wireless radio frequency energy for delivery. The remaining device can be wirelessly connected for data collection. PMID:23897048

  11. Transforming the present--discovering the future: the University of Pittsburgh's NLM grant on education and training of health sciences librarians.

    PubMed Central

    Detlefsen, E G; Epstein, B A; Mickelson, P; Detre, T

    1996-01-01

    BACKGROUND: The University of Pittsburgh was awarded a grant by the National Library of Medicine to study the education and training needs of present and future medical librarians and health information specialists through a collaboration of the university's School of Information Sciences and Health Sciences Library System. Goals and objectives for the year-long project included (1) assessment of education and training needs of medical librarians, (2) development of a master of library science curriculum and an internship program that would prepare graduates to take leadership roles in medical librarianship or information management, (3) development of continuing education programs for medical librarians in different formats, and (4) development of targeted recruitment efforts to attract minority group members and individuals with undergraduate science majors. The importance of this project, present practice, and success factors for programs seeking excellence in the preparation of health sciences information professionals are reviewed. A needs assessment involving a national advisory panel and a follow-up study of individuals who have participated in previous specialized training programs in health sciences information, compared with a peer group of medical librarians who did not participate in such programs, is described. This paper presents the goals and objectives of the project, describes the methods used, and outlines a curriculum, continuing education initiatives, and recruitment activities. PMID:8913555

  12. The Pittsburgh sleep quality index as a screening tool for sleep dysfunction in clinical and non-clinical samples: A systematic review and meta-analysis.

    PubMed

    Mollayeva, Tatyana; Thurairajah, Pravheen; Burton, Kirsteen; Mollayeva, Shirin; Shapiro, Colin M; Colantonio, Angela

    2016-02-01

    This review appraises the process of development and the measurement properties of the Pittsburgh sleep quality index (PSQI), gauging its potential as a screening tool for sleep dysfunction in non-clinical and clinical samples; it also compares non-clinical and clinical populations in terms of PSQI scores. MEDLINE, Embase, PsycINFO, and HAPI databases were searched. Critical appraisal of studies of measurement properties was performed using COSMIN. Of 37 reviewed studies, 22 examined construct validity, 19 - known-group validity, 15 - internal consistency, and three - test-retest reliability. Study quality ranged from poor to excellent, with the majority designated fair. Internal consistency, based on Cronbach's alpha, was good. Discrepancies were observed in factor analytic studies. In non-clinical and clinical samples with known differences in sleep quality, the PSQI global scores and all subscale scores, with the exception of sleep disturbance, differed significantly. The best evidence synthesis for the PSQI showed strong reliability and validity, and moderate structural validity in a variety of samples, suggesting the tool fulfills its intended utility. A taxonometric analysis can contribute to better understanding of sleep dysfunction as either a dichotomous or continuous construct. PMID:26163057

  13. History and dating of the publication of the Philadelphia (1822) and London (1823) editions of Edwin James's Account of an expedition from Pittsburgh to the Rocky Mountains

    USGS Publications Warehouse

    Woodman, Neal

    2010-01-01

    The public record of Major Stephen H. Long's 1819–1820 exploration of the American north-west, Account of an expedition from Pittsburgh to the Rocky Mountains, compiled by Edwin James, contains valuable contributions regarding the natural landscapes, native peoples and wildlife of a mostly unexplored region of the American west compiled from the notes of some of America's foremost naturalists, and it includes the first descriptions of 67 new species. The original plan was to publish the Account in Philadelphia and London simultaneously, yet these two editions differ substantially in ways that are relevant to the taxonomic contributions in the work. It is generally assumed that the Philadelphia edition was published in early January 1823 and was available first, but little substantive evidence has been presented to support its priority over the London edition. Review of contemporary correspondence and periodicals indicates the Philadelphia edition was available and for sale on 31 December 1822, whereas the London edition was available in late February 1823. As previously assumed by most sources, the Philadelphia edition has priority of publication and is the authority for most species names. Its correct year of publication, however, is 1822 rather than 1823.

  14. [Measurement of serum PA values by a newly developed enzyme immunoassay].

    PubMed

    Kuriyama, M; Esaki, N; Shinoda, I; Ito, S; Yamada, S; Tokuyama, K; Deguchi, T; Takahashi, Y; Kawada, Y; Akimoto, S

    1993-02-01

    Serum prostate-specific antigen (PA) values detected by a newly developed enzyme immunoassay (EIA, MARKIT-M PA) as a successor of MARKIT-F PA, which has been a leading kit in Japan, were evaluated for its role in the diagnosis of cancer of the prostate and follow-up of the patients afflicted with the disease. The system is one-step sandwich type EIA using horseradish peroxidase as a tracer and has 0.50-100 ng/ml of detectable range with small amount of sample volume (25 microliters) and reliable quality control data. Furthermore, serum PA values detected by the assay were almost equivocal to those detected by MARKIT-F PA. Serum PA values in prostate cancer patients (n = 122) were statistically higher than those in normal males (n = 90), urological malignancies other than prostate cancer (n = 48) or benign prostatic hypertrophy (BPH, n = 73). Even in the patients with stage A and B prostate cancer, serum PA values were observed to be statistically higher than those in BPH cases. If 3.6 ng/ml was used, which is normal value in MARKIT-F PA, as a cut-off value and BPH cases as a control, the sensitivity, specificity and efficacy for diagnosis of prostate cancer were 77.9, 91.8 and 83.1%, respectively, which showed the best results during the range examined. Serially determined serum PA values in following up the patients with prostate cancer were confirmed to be highly effective to evaluate treatment responses. These results suggest that MARKIT-M PA is thought to be one of the best tool for determination of serum PA values. PMID:7681886

  15. 231Pa/230Th records of Arctic/Atlantic interchange in Fram Strait

    NASA Astrophysics Data System (ADS)

    Hoffmann, S. S.; McDermott, K. J.; McManus, J. F.; Mukasa, S. B.

    2014-12-01

    Fram Strait, the Arctic Ocean's only deep passage for exchange with lower latitude oceans, today serves as a conduit for waters flowing north into the Arctic Ocean and south into the Atlantic. Reconstruction of circulation patterns and strength at depth in the strait can help to clarify the history of Arctic/Atlantic deep water exchange and Arctic contributions to global meridional overturning circulation. We will present new sedimentary measurements of radioisotopes 231Pa and 230Th to provide information on this exchange in the past and its relationship to sedimentation and climatic events. Coretop and downcore 231Pa/230Th ratios from Arctic sediments indicate that 231Pa has been exported from the central Arctic basin throughout the Holocene and deglaciation. Fram Strait represents a possible sink for this "missing" 231Pa. Preliminary results from ODP Holes 908A and 909A, at 1274 m and 2519 m water depths respectively in the central strait, suggest that ratios in this region during the Holocene have varied between ~0.106 (above the 231Pa/230Th production ratio of 0.093 in seawater, indicating net import of 231Pa)and ~0.055 (well below the production ratio, indicating net export of 231Pa). Further measurements in cores from the Greenland and Svalbard continental slopes will give a fuller regional picture of 231Pa deposition and transport across the strait.

  16. Thrombolytic efficacy and enzymatic activity of rt-PA-loaded echogenic liposomes.

    PubMed

    Bader, Kenneth B; Bouchoux, Guillaume; Peng, Tao; Klegerman, Melvin E; McPherson, David D; Holland, Christy K

    2015-08-01

    Echogenic liposomes (ELIP), that can encapsulate both recombinant tissue-type plasminogen activator (rt-PA) and microbubbles, are under development to improve the treatment of thrombo-occlusive disease. However, the enzymatic activity, thrombolytic efficacy, and stable cavitation activity generated by this agent has yet to be evaluated and compared to another established ultrasound-enhanced thrombolytic scheme. A spectrophotometric method was used to compare the enzymatic activity of the rt-PA incorporated into ELIP (t-ELIP) to that of rt-PA. An in vitro flow model was employed to measure the thrombolytic efficacy and dose of ultraharmonic emissions from stable cavitation for 120-kHz ultrasound exposure of three treatment schemes: rt-PA, rt-PA and the perfluorocarbon-filled microbubble Definity(®), and t-ELIP. The enzymatic activity of rt-PA incorporated into t-ELIP was 28 % that of rt-PA. Thrombolytic efficacy of t-ELIP or rt-PA and Definity(®) was equivalent when the dose of t-ELIP was adjusted to produce comparable enzymatic activity. Sustained bubble activity was nucleated from Definity but not from t-ELIP exposed to 120-kHz ultrasound. These results emphasize the advantages of encapsulating a thrombolytic and the importance of incorporating an insoluble gas required to promote sustained, stable cavitation activity. PMID:25829338

  17. 32 CFR 701.7 - Relationship between the FOIA and PA.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false Relationship between the FOIA and PA. 701.7... OF THE NAVY DOCUMENTS AFFECTING THE PUBLIC Department of the Navy Freedom of Information Act (FOIA) Program § 701.7 Relationship between the FOIA and PA. Not all requesters are knowledgeable of...

  18. 32 CFR 701.7 - Relationship between the FOIA and PA.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 5 2014-07-01 2014-07-01 false Relationship between the FOIA and PA. 701.7... OF THE NAVY DOCUMENTS AFFECTING THE PUBLIC Department of the Navy Freedom of Information Act (FOIA) Program § 701.7 Relationship between the FOIA and PA. Not all requesters are knowledgeable of...

  19. 32 CFR 701.7 - Relationship between the FOIA and PA.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 5 2013-07-01 2013-07-01 false Relationship between the FOIA and PA. 701.7... OF THE NAVY DOCUMENTS AFFECTING THE PUBLIC Department of the Navy Freedom of Information Act (FOIA) Program § 701.7 Relationship between the FOIA and PA. Not all requesters are knowledgeable of...

  20. 32 CFR 701.7 - Relationship between the FOIA and PA.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 5 2012-07-01 2012-07-01 false Relationship between the FOIA and PA. 701.7... OF THE NAVY DOCUMENTS AFFECTING THE PUBLIC Department of the Navy Freedom of Information Act (FOIA) Program § 701.7 Relationship between the FOIA and PA. Not all requesters are knowledgeable of...

  1. 32 CFR 701.7 - Relationship between the FOIA and PA.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 5 2011-07-01 2011-07-01 false Relationship between the FOIA and PA. 701.7... OF THE NAVY DOCUMENTS AFFECTING THE PUBLIC Department of the Navy Freedom of Information Act (FOIA) Program § 701.7 Relationship between the FOIA and PA. Not all requesters are knowledgeable of...

  2. Investigation of the salicylaldehyde thiosemicarbazone scaffold for inhibition of influenza virus PA endonuclease.

    PubMed

    Rogolino, Dominga; Bacchi, Alessia; De Luca, Laura; Rispoli, Gabriele; Sechi, Mario; Stevaert, Annelies; Naesens, Lieve; Carcelli, Mauro

    2015-10-01

    The influenza virus PA endonuclease is an attractive target for the development of novel anti-influenza virus therapeutics, which are urgently needed because of the emergence of drug-resistant viral strains. Reported PA inhibitors are assumed to chelate the divalent metal ion(s) (Mg²⁺ or Mn²⁺) in the enzyme's catalytic site, which is located in the N-terminal part of PA (PA-Nter). In the present work, a series of salicylaldehyde thiosemicarbazone derivatives have been synthesized and evaluated for their ability to inhibit the PA-Nter catalytic activity. Compounds 1-6 have been evaluated against influenza virus, both in enzymatic assays with influenza virus PA-Nter and in virus yield assays in MDCK cells. In order to establish a structure-activity relationship, the hydrazone analogue of the most active thiosemicarbazone has also been evaluated. Since chelation may represent a mode of action of such class of molecules, we studied the interaction of two of them, one with and one without biological activity versus the PA enzyme, towards Mg²⁺, the ion that is probably involved in the endonuclease activity of the heterotrimeric influenza polymerase complex. The crystal structure of the magnesium complex of the o-vanillin thiosemicarbazone ligand 1 is also described. Moreover, docking studies of PA endonuclease with compounds 1 and 2 were performed, to further analyse the possible mechanism of action of this class of inhibitors. PMID:26323352

  3. New Insight into Metal Ion-Driven Catalysis of Nucleic Acids by Influenza PA-Nter

    PubMed Central

    Kotlarek, Daria; Worch, Remigiusz

    2016-01-01

    PA subunit of influenza RNA-dependent RNA polymerase deserves constantly increasing attention due to its essential role in influenza life cycle. N-terminal domain of PA (PA-Nter) harbors endonuclease activity, which is indispensable in viral transcription and replication. Interestingly, existing literature reports on in vitro ion preferences of the enzyme are contradictory. Some show PA-Nter activity exclusively with Mn2+, whereas others report Mg2+ as a natural cofactor. To clarify it, we performed a series of experiments with varied ion concentrations and substrate type. We observed cleavage in the presence of both ions, with a slight preference for manganese, however PA-Nter activity highly depended on the amount of residual, co-purified ions. Furthermore, to quantify cleavage reaction rate, we applied fluorescence cross-correlation spectroscopy (FCCS), providing highly sensitive and real-time monitoring of single molecules. Using nanomolar ssDNA in the regime of enzyme excess, we estimated the maximum reaction rate at 0.81± 0.38 and 1.38± 0.34 nM/min for Mg2+ and Mn2+, respectively. However, our calculations of PA-Nter ion occupancy, based on thermodynamic data, suggest Mg2+ to be a canonical metal in PA-Nter processing of RNA in vivo. Presented studies constitute a step toward better understanding of PA-Nter ion-dependent activity, which will possibly contribute to new successful inhibitor design in the future. PMID:27300442

  4. Interferon gamma regulates accumulation of the proteasome activator PA28 and immunoproteasomes at nuclear PML bodies.

    PubMed

    Fabunmi, R P; Wigley, W C; Thomas, P J; DeMartino, G N

    2001-01-01

    PA28 is an interferon (gamma) (IFN(gamma)) inducible proteasome activator required for presentation of certain major histocompatibility (MHC) class I antigens. Under basal conditions in HeLa and Hep2 cells, a portion of nuclear PA28 is concentrated at promyelocytic leukemia oncoprotein (PML)-containing bodies also commonly known as PODs or ND10. IFN(gamma) treatment greatly increased the number and size of the PA28- and PML-containing bodies, and the effect was further enhanced in serum-deprived cells. PML bodies are disrupted in response to certain viral infections and in diseases such as acute promyelocytic leukemia (APL). Like PML, PA28 was delocalized from PML bodies by expression of the cytomegalovirus protein, IE1, and in NB4 cells, an APL model line. Moreover, retinoic acid treatment, which causes remission of APL in patients and reformation of PML-containing bodies in NB4 cells, relocalized PA28 to this site. In contrast, the proteasome, the functional target of PA28, was not detected at PML bodies under basal conditions in HeLa and Hep2 cells, but IFN(gamma) promoted accumulation of 'immunoproteasomes' at this site. These results establish PA28 as a novel component of nuclear PML bodies, and suggest that PA28 may assemble or activate immunoproteasomes at this site as part of its role in proteasome-dependent MHC class I antigen presentation. PMID:11112687

  5. 76 FR 51469 - CSX Transportation, Inc.-Abandonment Exemption-in Beaver County, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-18

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Surface Transportation Board CSX Transportation, Inc.--Abandonment Exemption--in Beaver County, PA CSX..., between milepost PLK 0.0 and milepost PLK 2.39, in Koppel, Beaver County, Pa. The line traverses...

  6. PA-560, A Root-Knot Nematode Resistant, Yellow-fruited, Habanero-type Pepper

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Efforts to develop a yellow-fruited, Habanero-type pepper (Capsicum chinense Jacq.) that is highly resistant to root-knot nematodes were completed with the official release of PA-560 on October 20, 2009. PA-560, an advanced breeding line, is the product of a backcross/pedigree breeding procedure to...

  7. 78 FR 72007 - Establishment of Class E Airspace; McConnellsburg, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-02

    ... Class E Airspace at McConnellsburg, PA, to accommodate a new Area Navigation (RNAV) Global Positioning... proposed rulemaking (NPRM) to establish Class E airspace at McConnellsburg, PA, (78 FR 48081) Docket No... ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3)...

  8. Tell Me about Fred's Fat Foot Again: Four Tips for Successful PA Lessons

    ERIC Educational Resources Information Center

    Murray, Bruce A.

    2012-01-01

    This teaching tip applies research on phoneme awareness (PA) to propose an instructional model for teaching PA. Research suggests children need to learn the identifying features of phonemes to recognize them in spoken words. In the model, teachers focus on one phoneme at a time; make it memorable to children through sound analogies supported by…

  9. Ultrasound-enhanced thrombolysis with tPA-loaded echogenic liposomes

    PubMed Central

    Shaw, George J.; Meunier, Jason M.; Huang, Shao-Ling; Lindsell, Christopher J.; McPherson, David D.; Holland, Christy K.

    2009-01-01

    Background and Purpose Currently, the only FDA-approved therapy for acute ischemic stroke is the administration of recombinant tissue plasminogen activator (tPA). Echogenic liposomes (ELIP), phospholipid vesicles filled with gas and fluid, can be manufactured to incorporate tPA. Also, transcranial ultrasound-enhanced thrombolysis can increase the recanalization rate in stroke patients. However, there is little data on lytic efficacy of combining ultrasound, echogenic liposomes, and tPA treatment. In this study, we measure the effects of pulsed 120-kHz ultrasound on the lytic efficacy of tPA and tPA-incorporating ELIP (t-ELIP) in an in-vitro human clot model. It is hypothesized that t-ELIP exhibits similar lytic efficacy to that of rt-PA. Methods: Blood was drawn from 22 subjects after IRB approval. Clots were made in 20-μL pipettes, and placed in a water tank for microscopic visualization during ultrasound and drug treatment. Clots were exposed to combinations of [tPA] = 3.15 μg/ml, [t-ELIP] = 3.15 μg/ml, and 120-kHz ultrasound for 30 minutes at 37 °C in human plasma. At least 12 clots were used for each treatment. Clot lysis over time was imaged and clot diameter was measured over time, using previously developed imaging analysis algorithms. The fractional clot loss (FCL), which is the decrease in mean clot width at the end of lytic treatment, was used as a measure of lytic efficacy for the various treatment regimens. Results: The fractional clot loss FCL was 31% (95% CI: 26-37%) and 71% (56-86%) for clots exposed to tPA alone or tPA with 120 kHz ultrasound. Similarly, FCL was 48% (31-64%) and 89% (76-100%) for clots exposed to tELIP without or with ultrasound. Conclusions: The lytic efficacy of tPA containing echogenic liposomes is comparable to that of tPA alone. The addition of 120 kHz ultrasound significantly enhanced lytic treatment efficacy for both tPA and t-ELIP. Liposomes loaded with tPA may be a useful adjunct in lytic treatment with tPA. PMID

  10. Conformations of tissue plasminogen activator (tPA) orchestrate neuronal survival by a crosstalk between EGFR and NMDAR

    PubMed Central

    Bertrand, T; Lesept, F; Chevilley, A; Lenoir, S; Aimable, M; Briens, A; Hommet, Y; Bardou, I; Parcq, J; Vivien, D

    2015-01-01

    Tissue-type plasminogen activator (tPA) is a pleiotropic serine protease of the central nervous system (CNS) with reported neurotrophic and neurotoxic functions. Produced and released under its single chain form (sc), the sc-tPA can be cleaved by plasmin or kallikrein in a two chain form, tc-tPA. Although both sc-tPA and tc-tPA display a similar fibrinolytic activity, we postulated here that these two conformations of tPA (sc-tPA and tc-tPA) could differentially control the effects of tPA on neuronal survival. Using primary cultures of mouse cortical neurons, our present study reveals that sc-tPA is the only one capable to promote N-methyl-D-aspartate receptor (NMDAR)-induced calcium influx and subsequent excitotoxicity. In contrast, both sc-tPA and tc-tPA are capable to activate epidermal growth factor receptors (EGFRs), a mechanism mediating the antiapoptotic effects of tPA. Interestingly, we revealed a tPA dependent crosstalk between EGFR and NMDAR in which a tPA-dependent activation of EGFRs leads to downregulation of NMDAR signaling and to subsequent neurotrophic effects. PMID:26469972

  11. A novel plasminogen activator from Agkistrodon blomhoffii Ussurensis venom (ABUSV-PA): Purification and characterization

    SciTech Connect

    Liu Shuqing; Sun Mingzhong . E-mail: ming-zhong.sun@case.edu; Greenaway, Frederick T.

    2006-10-06

    A plasminogen activator with arginine ester hydrolysis activity (ABUSV-PA) has been identified and purified to homogeneity from Chinese Agkistrodon blomhoffii Ussurensis snake venom. ABUSV-PA, a monomeric protein with molecular mass of 27815.2 Da, was purified 180-fold with 0.02% recovery for protein and 3.6% recovery for esterase activity. ABUSV-PA reacts optimally with its substrate N {sub {alpha}}-tosyl-L-arginine-methyl ester (TAME) at {approx}pH 7.5 and at 51 {sup o}C. Measurement from inductively coupled plasma-atomic emission spectroscopy (ICP-AES) reveals that ABUSV-PA is a Zn{sup 2+}-containing protein with a stoichiometry of 1:1 [Zn{sup 2+}]:[ABUSV-PA]. Analyses of esterase hydrolysis and UV absorption and CD spectra indicate that Zn{sup 2+} plays an important role in maintaining the structural integrity rather than the esterase activity of ABUSV-PA. Divalent metal ions, including Ca{sup 2+}, Mg{sup 2+}, Cu{sup 2+}, Ni{sup 2+}, Mn{sup 2+}, and Co{sup 2+}, increase the TAME hydrolysis activity of ABUSV-PA. A red-shift of the emission wavelengths of the synchronous fluorescence of ABUSV-PA, compared to those of free Tyr and Trp, indicates a conformation where the Tyr and Trp residues are in exposed hydrophilic environments. The presence of zinc increases the hydrophobicity of the conformational environments surrounding the Trp residues of ABUSV-PA and affects the secondary structure of ABUSV-PA, as proved by UV absorption and CD spectroscopy.

  12. Effects of Pseudomonas aeruginosa mannose-sensitive hemagglutinin (PA-MSHA) pretreatment on septic rats.

    PubMed

    Zhu, Hechen; Wang, Shiqiang; Shen, Lei; Wang, Wei; Zhao, Feng; Cao, Tongwa

    2013-11-01

    To evaluate the effects of Pseudomonas aeruginosa mannose-sensitive hemagglutinin (PA-MSHA) injection on the survival rate of rats post cecal ligation and puncture (CLP), Sprague-Dawley (SD) rats were subcutaneously injected with 0.125 ml, 0.25 ml or 0.5 ml PA-MSHA for 8 days or 16 days before CLP. The survival rate and physiological appearance of rats in each group were monitored daily post CLP. The expression of Toll-like receptor 4 (TLR4) and cytokines related to inflammation was evaluated. We found that the 0.5 ml-8d (0.5 ml PA-MSHA injected for 8 days) group had the highest 7-day survival rate (91.7%), which was significantly improved compared with the CLP-only group (33.3%). Furthermore, our results showed that PA-MSHA effectively increased serum pro-inflammatory mediators (TNF-α, IL-1β and IL-6) at the early stage (8 days) but increased anti-inflammatory mediators (IL-4 and IL-10) at the late stage (16 days). PA-MSHA significantly up-regulated the mRNA expression of TLR4 at 8 and 16 days. After PA-MSHA pretreatment, CLP had no marked effect on the levels of most inflammatory factors. To explore potential protective mechanisms of PA-MSHA against CLP, we examined the effect of PA-MSHA on murine macrophage-like RAW264.7 cells and found that PA-MSHA induced endotoxin tolerance. In conclusion, this study suggested that precisely controlling the dosage and time of PA-MSHA administration can effectively increase the rat survival rate post CLP, which may be mediated through regulating inflammatory mediators and inducing endotoxin tolerance. PMID:24055021

  13. Bilateral key comparison CCM.P-K3.1 for absolute pressure measurements from 3 × 10-6 Pa to 9 × 10-4 Pa

    NASA Astrophysics Data System (ADS)

    Fedchak, J. A.; Bock, Th; Jousten, K.

    2014-01-01

    This report describes the bilateral key comparison CCM.P-K3.1 between the National Institute of Standards and Technology (NIST) and Physikalisch-Technische Bundesanstalt (PTB) for absolute pressure in the range from 3 × 10-6 Pa to 9 × 10-4 Pa. This comparison was a follow-up to the comparison CCM.P-K3. Two ionization gauges and two spinning rotor gauges (SRGs) were used as the transfer standards for the comparison. The SRGs were used to compare the standards at a pressure of 9 × 10-4 Pa and to normalize the ionization gauge readings. The two ionization gauges were used to compare the standards in the pressure range of from 3 × 10-6 Pa to 3 × 10-4 Pa. Both laboratories used dynamic expansion chambers as standards in the comparison. The two labs showed excellent agreement with each other and with the CCM.P-K3 key comparison reference value (KCRV) over the entire range. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

  14. Effect of Fagonia arabica on thrombin induced release of t-PA and complex of PAI-1 tPA in cultured HUVE cells.

    PubMed

    Aloni, Prutha D; Nayak, Amit R; Chaurasia, Sweta R; Deopujari, Jayant Y; Chourasia, Chhaya; Purohit, Hemant J; Taori, Girdhar M; Daginawala, Hatim F; Kashyap, Rajpal S

    2016-07-01

    Fagonia arabica (FA) possesses a thrombolytic property which has been earlier reported in our laboratory. Current study was undertaken to investigate the effect of aqueous extract of FA on thrombin-induced tissue plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) release from cultured human umbilical vein endothelial cell line (HUVE) for studying its clot lytic activity. For this, establishment of cell line model has been done by isolating the cells from human umbilical cord. Cell toxicity was evaluated using XTT assay. Estimation of t-PA and PAI-1 t-PA complex were done using ELISA technique. Thrombin treatment induces the t-PA and PAI-1 release from HUVE cell line, and FA treatment was found to antagonize the thrombin induced t-PA and PAI-1 release. Our preliminary results suggest that FA may be used as an alternative to thrombolytic drug. However, study demands further experiments using animal model of thrombosis to establish the role of FA as a novel thrombolytic drug. PMID:27419084

  15. Fosfomycin Resistance in Escherichia coli, Pennsylvania, USA

    PubMed Central

    Alrowais, Hind; McElheny, Christi L.; Spychala, Caressa N.; Sastry, Sangeeta; Guo, Qinglan; Butt, Adeel A.

    2015-01-01

    Fosfomycin resistance in Escherichia coli is rare in the United States. An extended-spectrum β-lactamase–producing E. coli clinical strain identified in Pennsylvania, USA, showed high-level fosfomycin resistance caused by the fosA3 gene. The IncFII plasmid carrying this gene had a structure similar to those found in China, where fosfomycin resistance is commonly described. PMID:26488485

  16. Big Bend National Park, TX, USA, Mexico

    NASA Technical Reports Server (NTRS)

    1991-01-01

    The Sierra del Carmen of Mexico, across the Rio Grande River from Big Bend National Park, TX, (28.5N, 104.0W) is centered in this photo. The Rio Grande River bisects the scene; Mexico to the east, USA to the west. The thousand ft. Boquillas limestone cliff on the Mexican side of the river changes colors from white to pink to lavender at sunset. This severely eroded sedimentary landscape was once an ancient seabed later overlaid with volcanic activity.

  17. Differential amplification of satellite PaB6 in chromosomally hypervariable Prospero autumnale complex (Hyacinthaceae)

    PubMed Central

    Emadzade, Khatere; Jang, Tae-Soo; Macas, Jiří; Kovařík, Ales; Novák, Petr; Parker, John; Weiss-Schneeweiss, Hanna

    2014-01-01

    Background and Aims Chromosomal evolution, including numerical and structural changes, is a major force in plant diversification and speciation. This study addresses genomic changes associated with the extensive chromosomal variation of the Mediterranean Prospero autumnale complex (Hyacinthaceae), which includes four diploid cytotypes each with a unique combination of chromosome number (x = 5, 6, 7), rDNA loci and genome size. Methods A new satellite repeat PaB6 has previously been identified, and monomers were reconstructed from next-generation sequencing (NGS) data of P. autumnale cytotype B6B6 (2n = 12). Monomers of all other Prospero cytotypes and species were sequenced to check for lineage-specific mutations. Copy number, restriction patterns and methylation levels of PaB6 were analysed using Southern blotting. PaB6 was localized on chromosomes using fluorescence in situ hybridization (FISH). Key Results The monomer of PaB6 is 249 bp long, contains several intact and truncated vertebrate-type telomeric repeats and is highly methylated. PaB6 is exceptional because of its high copy number and unprecedented variation among diploid cytotypes, ranging from 104 to 106 copies per 1C. PaB6 is always located in pericentromeric regions of several to all chromosomes. Additionally, two lineages of cytotype B7B7 (x = 7), possessing either a single or duplicated 5S rDNA locus, differ in PaB6 copy number; the ancestral condition of a single locus is associated with higher PaB6 copy numbers. Conclusions Although present in all Prospero species, PaB6 has undergone differential amplification only in chromosomally variable P. autumnale, particularly in cytotypes B6B6 and B5B5. These arose via independent chromosomal fusions from x = 7 to x = 6 and 5, respectively, accompanied by genome size increases. The copy numbers of satellite DNA PaB6 are among the highest in angiosperms, and changes of PaB6 are exceptionally dynamic in this group of closely related cytotypes of a single

  18. Overexpression of PaFT gene in the wild orchid Phalaenopsis amabilis (L.) Blume

    NASA Astrophysics Data System (ADS)

    Semiarti, Endang; Mercuriani, Ixora S.; Rizal, Rinaldi; Slamet, Agus; Utami, Bekti S.; Bestari, Ida A.; Aziz-Purwantoro, Moeljopawiro, S.; Jang, Soenghoe; Machida, Y.; Machida, C.

    2015-09-01

    To shorten vegetative stage and induce transition from vegetative to reproductive stage in orchids, we overexpressed Phalaenopsis amabilis Flowering LocusT (PaFT) gene under the control of Ubiquitin promoter into protocorm of Indonesian Wild Orchid Phalaenopsis amabilis (L.) Blume. The dynamic expression of vegetative gene Phalaenopsis Homeobox1 (POH1) and flowering time gene PaFT has been analyzed. Accumulation of mRNA was detected in shoot and leaves of both transgenic and non transgenic plants by using Reverse transcriptase-PCR (RT-PCR) with specific gene primers for POH1 and PaFT in 24 months old plants. To analyze the POH1 and PaFT genes, three pairs of degenerate primers PaFT degF1R1, F2R2 and F3R3 that amplified 531 bp PaFT cDNA were used. We detected 700 bp PaFTcDNA from leaves and shoots of transgenic plants, but not in NT plants. POH1 mRNA was detected in plants. PaFT protein consists of Phospatidyl Ethanolamine-Binding Protein (PEBP) in interval base 73-483 and CETS family protein at base 7-519, which are important motif for transmembrane protein. We inserted Ubipro::PaFT/pGAS101 into P. amabilis protocorm using Agrobacterium. Analysis of transgenic plants showed that PaFTmRNA was accumulated in leaves of 12 months after sowing, although it is not detected in non transgeic plants. Compare to the wild type (NT plants), ectopic expression of PaFT shows alter phenotype as follows: 31% normal, 19% with short-wavy leaves, 5% form rosette leaves and 45% produced multishoots. Analysis of protein profiles of trasgenic plants showed that a putative PaFT protein (MW 19,7 kDa) was produced in 1eaves and shoots.This means that at 12 months, POH1 gene expression gradually decreased/negatively regulated, the expression of PaFT gene was activated, although there is no flower initiation yet. Some environmental factors might play a role to induce inflorescens. This experiment is in progress.

  19. Fluxes of 230Th and 231Pa to the deep sea: implications for the interpretation of excess 230Th and 231Pa/ 230Th profiles in sediments

    NASA Astrophysics Data System (ADS)

    Yu, E.-F.; Francois, R.; Bacon, M. P.; Fleer, A. P.

    2001-09-01

    Analysis of samples obtained with deep-sea moored sediment traps deployed at 15 sites representing a wide range of oceanic conditions confirms that the flux of 230Th scavenged to the seafloor remains close to its production rate from the decay of 234U in the overlying water column, and generally validates the use of 230Th as a normalizing tool for paleoflux reconstruction. After correction for trapping efficiency, the flux of 230Th measured in the low flux regions amounts to 90±6% of the production rate, with the notable exceptions of one site near the Arabian Sea upwelling and one site in the Weddell Sea. A 230Th flux equivalent to 120% of the production rate was found in Panama Basin. Similar or more extensive scavenging of 230Th may be occurring at a Pacific margin site off California and south of the Polar Front, but these estimates are obscured by large errors on our trapping-efficiency estimates. In contrast, the flux of 231Pa and the 231Pa/ 230Th ratio can vary strongly with particle flux, following distinct trends in different oceanic basins. In the Atlantic Ocean, 231Pa fluxes and 231Pa/ 230Th are low and not sensitive to particle flux. This is because of the short residence time of deep water in this basin resulting from thermohaline circulation, which prevents the full development of lateral concentration gradients and full expression of boundary scavenging. In the Pacific Ocean, the sensitivity of 231Pa/ 230Th to particle flux is highest, reflecting the longer residence time of deep water. In the southern ocean, 231Pa/ 230Th ratios are invariably high, even when particle fluxes are low, reflecting the predominance of opal, which fractionates minimally between the two radionuclides. Interpretation of 231Pa/ 230Th recorded in sediments is thus complex. In the Atlantic, this ratio is better suited for recording past changes in the strength of thermohaline circulation. In the Pacific, it has the best potential for providing synoptic maps of past changes in

  20. Individual expression of influenza virus PA protein induces degradation of coexpressed proteins.

    PubMed Central

    Sanz-Ezquerro, J J; de la Luna, S; Ortín, J; Nieto, A

    1995-01-01

    In the process of in vivo reconstitution of influenza virus transcriptase-replicase complex, an inhibitory effect was observed when the level of PA protein expression was increased. This inhibition was paralleled by a decrease in the accumulation of the other influenza virus core proteins. The sole expression of PA protein was sufficient to reduce the accumulation level of the proteins encoded by the coexpressed genes. The PA effect was observed upon influenza virus and non-influenza virus proteins and independently of the expression system chosen and the origin of cell line used. The expression of PA protein did not induce variations in the translation of the target proteins but did induce variations on their half-lives, which were clearly reduced. A functional PA subunit seems to be necessary to induce this negative effect, because an inactive point mutant was unable to decrease the steady-state levels or the half-lives of the reporter proteins. The PA effect was observed as early as 5 h after its expression, and continuous synthesis of proteins was not required for performance of its biological activity. The results presented represent the first biological activity of individually expressed PA polymerase subunit. PMID:7884889

  1. Impacts of tissue-type plasminogen activator (tPA) on neuronal survival

    PubMed Central

    Chevilley, Arnaud; Lesept, Flavie; Lenoir, Sophie; Ali, Carine; Parcq, Jérôme; Vivien, Denis

    2015-01-01

    Tissue-type plasminogen activator (tPA) a serine protease is constituted of five functional domains through which it interacts with different substrates, binding proteins, and receptors. In the last years, great interest has been given to the clinical relevance of targeting tPA in different diseases of the central nervous system, in particular stroke. Among its reported functions in the central nervous system, tPA displays both neurotrophic and neurotoxic effects. How can the protease mediate such opposite functions remain unclear but several hypotheses have been proposed. These include an influence of the degree of maturity and/or the type of neurons, of the level of tPA, of its origin (endogenous or exogenous) or of its form (single chain tPA versus two chain tPA). In this review, we will provide a synthetic snapshot of our current knowledge regarding the natural history of tPA and discuss how it sustains its pleiotropic functions with focus on excitotoxic/ischemic neuronal death and neuronal survival. PMID:26528141

  2. Demethylation-linked Activation of uPA is Involved in Progression of Prostate Cancer

    PubMed Central

    Pulukuri, Sai MuraliKrishna; Estes, Norman; Patel, Jitendra; Rao, Jasti S.

    2006-01-01

    Increased expression of urokinase plasminogen activator (uPA) has been reported in various malignancies including prostate cancer. However, the mechanism by which uPA is abnormally expressed in prostate cancer remains elusive. Here, we show that uPA is aberrantly expressed in a high-percentage of human prostate cancer tissues, but rarely expressed either in tumor-matched, non-neoplastic adjacent tissues (NNAT) or benign prostatic hyperplasia (BPH) samples. This aberrant expression is associated with cancer-linked demethylation of the uPA promoter. Furthermore, treatment with demethylation inhibitor S-Adenosylmethionine (Ado-Met) or stable expression of uPA shRNA significantly inhibits uPA expression and tumor cell invasion in vitro and tumor growth and incidence of lung metastasis in vivo. Collectively, these findings strongly suggest that DNA demethylation is a common mechanism underlying the abnormal expression of uPA and is a critical contributing factor to the malignant progression of human prostate tumors. PMID:17283123

  3. The Orion Pad Abort 1 (PA-1) Flight Test: A Propulsion Success

    NASA Technical Reports Server (NTRS)

    Jones, Daniel S.

    2015-01-01

    This poster provides a concise overview of the highly successful Orion Pad Abort 1 (PA-1) flight test, and the three rocket motors that contributed to this success. The primary purpose of the Orion PA-1 flight was to help certify the Orion Launch Abort System (LAS), which can be utilized in the unlikely event of an emergency on the launchpad or during mission vehicle ascent. The PA-1 test was the first fully integrated flight test of the Orion LAS, one of the primary systems within the Orion Multi-Purpose Crew Vehicle (MPCV). The Orion MPCV is part of the architecture within the Space Launch System (SLS), which is being designed to transport astronauts beyond low-Earth orbit for future exploration missions. Had the Orion PA-1 flight abort occurred during launch preparations for a real human spaceflight mission, the PA-1 LAS would have saved the lives of the crew. The PA-1 flight test was largely successful due to the three solid rocket motors of the LAS: the Attitude Control Motor (ACM); the Jettison Motor (JM); and the Abort Motor (AM). All three rocket motors successfully performed their required functions during the Orion PA-1 flight test, flown on May 6, 2010 at the White Sands Missile Range in New Mexico, culminating in a successful demonstration of an abort capability from the launchpad.

  4. Orion Launch Abort System (LAS) Propulsion on Pad Abort 1 (PA-1)

    NASA Technical Reports Server (NTRS)

    Jones, Daniel S.

    2015-01-01

    This presentation provides a concise overview of the highly successful Orion Pad Abort 1 (PA-1) flight test, and the three rocket motors that contributed to this success. The primary purpose of the Orion PA-1 flight was to help certify the Orion Launch Abort System (LAS), which can be utilized in the unlikely event of an emergency on the launchpad or during mission vehicle ascent. The PA-1 test was the first fully integrated flight test of the Orion LAS, one of the primary systems within the Orion Multi-Purpose Crew Vehicle (MPCV). The Orion MPCV is part of the architecture within the Space Launch System (SLS), which is being designed to transport astronauts beyond low-Earth orbit for future exploration missions. Had the Orion PA-1 flight abort occurred during launch preparations for a real human spaceflight mission, the PA-1 LAS would have saved the lives of the crew. The PA-1 flight test was largely successful due to the three solid rocket motors of the LAS: the Attitude Control Motor (ACM); the Jettison Motor (JM); and the Abort Motor (AM). All three rocket motors successfully performed their required functions during the Orion PA-1 flight test, flown on May 6, 2010 at the White Sands Missile Range in New Mexico, culminating in a successful demonstration of an abort capability from the launchpad.

  5. Absence of PIttsburgh Compound B Detection of CerebralAmyloid Beta in a Patient With Clinical, Cognitive, and Cerebrospinal FluidMarkers of Alzheimer Disease

    PubMed Central

    Cairns, Nigel J.; Ikonomovic, Milos D.; Benzinger, Tammie; Storandt, Martha; Fagan, Anne M; Shah, Arti; Schmidt, Robert E.; Perry, Arie; Reinwald, Lisa Taylor; Carter, Deborah; Felton, Angela; Holtzman, David M.; Mintun, Mark A.; Klunk, William E.; Morris, John C.

    2009-01-01

    Objective To determine the temporal relationships of clinical, cognitive, Pittsburgh Compound-B (PiB) amyloid imaging, and cerebrospinal fluid (CSF) markers of Alzheimer’s disease (AD). Design A case report of a longitudinally assessed participant in a memory and aging study who had serial clinical and psychometric assessments over 6 years, in addition to PiB imaging and CSF biomarker assays, prior to coming to autopsy. Setting Alzheimer’s Disease Research Center Findings An 85-year old individual was cognitively normal at his initial and next 3 annual assessments. Decline in measures of episodic memory and, to a lesser degree, working memory began at about age 88 years. PiB-PET amyloid imaging was negative at age 88.5 years, but at age 89.5 years there was reduced amyloid-beta 42 (Aβ42) and elevated levels of tau in the CSF. At his 6th assessment, when he was 90 years old, he was diagnosed with very mild dementia of the Alzheimer type. After death at age 91 years, the autopsy revealed foci of frequent neocortical diffuse Aβ plaques, sufficient to fulfill Khachaturian neuropathologic criteria for AD, but neuritic plaques and neurofibrillary tangles were sparse. Postmortem biochemical analysis of the cerebral tissue confirmed that PiB-PET-binding was below the level needed for in vivo detection. Conclusion Clinical, cognitive, and CSF markers consistent with AD may precede detection of cerebral Aβ with amyloid imaging agents such as PiB, which primarily label fibrillar Aβ plaques. PMID:20008664

  6. SRC burn test in 700-hp oil-designed boiler. Annex Volume B. DOE-Pittsburgh Energy Technology Center report. Final technical report

    SciTech Connect

    Not Available

    1983-09-01

    Solvent Refined Coal (SRC) combustion tests were conducted at the U.S. Department of Energy's Pittsburgh Energy Technology Center. Combustion and flue-gas treatment of three different physical forms of SRC, as well as a No. 6 fuel oil, were evaluated. The three SRC fuels were (1) pulverized SRC Fuel; (2) SRC Residual Fuel Oil; and (3) SRC/Water Slurry. The SRC Residual Fuel Oil was a solution of SRC Fuel dissolved in heated process solvent. Approximately 500 tons of pulverized SRC Fuel and 30,000 gallons of SRC Residual Fuel Oil were combusted in a 700 hp (30 x 130 x 10/sup 6/ Btu/hr fuel input) oil-designed watertube package boiler. Sixty four-hour ASME combustion tests with three different SRC fuels were successfully concluded. The principal parameters evaluated were excess air levels and combustion air preheat temperature levels. Extensive data were collected on flue-gas levels of O/sub 2/, CO/sub 2/, CO, unburned hydrocarbons, SO/sub x/, NO/sub x/, uncontrolled particulates, uncontrolled opacity and carbon content of the flue-gas particulates. Boiler and combustion efficiencies were measured. The particulates were characterized via mass loadings, impactors, in-situ resistivity measurements, ultra-fine sampling, optical large particle sampling, five-stage cyclone sampling and chemical analysis of various cut sizes. A three-field pilot electrostatic precipitator (ESP) containing over 1000 square feet of plate collection area, a reverse air fabric filter pilot dust collector and a commercial pulse-jet fabric filter dust collector were operated at high collection efficiency. The results will be valuable in making recommendations for future tests and will provide a basis for conversion of industrial oil-fired boilers to SRC fuels. 11 references, 20 figures, 29 tables.

  7. Characterization of liquids derived from laboratory coking of decant oil and co-coking of Pittsburgh seam bituminous coal with decant oil

    SciTech Connect

    Omer Gul; Caroline Clifford; Leslie R. Rudnick; Harold H. Schobert

    2009-05-15

    In this study, decant oil and a blend of Pittsburgh seam bituminous coal with decant oil were subjected to coking and co-coking in a laboratory-scale delayed coker. Higher yields of coke and gas were obtained from co-coking than from coking. Coal addition into the feedstock resulted in lighter overhead liquid. GC/MS analyses of gasoline, jet fuel, and diesel show that co-coking of coal/decant oil gave higher quantity aromatic components than that of coking of decant oil alone. Simulated distillation gas chromatography analyses of overhead liquids and GC/MS analyses of vacuum fractions show that when coal was reacted with a decant oil, the coal constituents contributed to the distillable liquids. To address the reproducibility of the liquid products, overhead liquid samples collected at the first, third, and fifth hours of experiments of 6 h duration were evaluated using simulated distillation gas chromatography and {sup 1}H and {sup 13}C NMR. NMR analyses of the liquid products showed that, even though there were slight changes in the {sup 1}H and {sup 13}C spectra, the standard deviation was low for the time-dependent samples. Simulated distillation gas chromatography showed that the yields of refinery boiling range materials (i.e., gasoline, jet fuel, diesel, and fuel oil cuts) were reproducible between runs. Fractionation of the overhead liquids into refinery boiling range materials (gasoline, jet fuel, diesel, fuel oil fractions) showed that the boiling range materials and chemical compositions of fractions were found to be reproducible. 54 refs., 17 tabs.

  8. Apportionment of Ambient Primary and Secondary PM 2.5 During a 2001 Summer Intensive Study at the NETL Pittsburgh Site Using PMF2 and EPA UNMIX

    SciTech Connect

    Eatough, D.J.; Anderson, R.R.; Martello, D.V.; Modey, W.K.; Mangelson, N.F.

    2006-10-01

    Apportionment of primary and secondary pollutants during a July 2001 intensive study at the National Energy Technology Laboratory is reported. PM 2.5 was apportioned into primary and secondary contributions using PMF2, and results were compared with apportionment based on UNMIX 2.3. Input to PMF2 included PM 2.5 mass data from four per 24 hour PC-BOSS filters and TEOM, NO x , NO 2 , O 3 , non-volatile, semi-volatile, and volatile organic material, elemental carbon, sulfate, and PIXE determined trace metals. Nine factors were identified in the PMF analysis. Six factors were associated with primary particles from crustal, mobile (gasoline and diesel), and three local sources high in trace metals. Three factors were associated with secondary sources. Two were associated with local emissions dominated by organic material, one was dominated by transported ammonium sulfate. UNMIX was able to identify the two major mobile sources, major local secondary source and transported secondary source. The three major sources of PM 2.5 were identified as secondary transported material (dominated by ammonium sulfate) from west and southwest (46%), secondary material formed during mid-day photochemical processes (21%), and primary emissions from diesel (10%) and gasoline (8%) mobile sources. The other five sources accounted for the remaining 15% of the PM 2.5 . These findings are consistent with the majority of secondary ammonium sulfate in the Pittsburgh area resulting from distant transport, and so decoupled from local activity involving organic pollutants in the metropolitan area. In contrast, the major local secondary sources were dominated by organic material.

  9. Design and Feasibility Assessment of a Retrospective Epidemiological Study of Coal-Fired Power Plant Emissions in the Pittsburgh Pennsylvania Region

    SciTech Connect

    Richard A. Bilonick; Daniel Connell; Evelyn Talbott; Jeanne Zborowski; Myoung Kim

    2006-12-20

    Eighty-nine (89) percent of the electricity supplied in the 35-county Pittsburgh region (comprising parts of the states of Pennsylvania, Ohio, West Virginia, and Maryland) is generated by coal-fired power plants making this an ideal region in which to study the effects of the fine airborne particulates designated as PM{sub 2.5} emitted by the combustion of coal. This report demonstrates that during the period from 1999-2006 (1) sufficient and extensive exposure data, in particular samples of speciated PM{sub 2.5} components from 1999 to 2003, and including gaseous co-pollutants and weather have been collected, (2) sufficient and extensive mortality, morbidity, and related health outcomes data are readily available, and (3) the relationship between health effects and fine particulates can most likely be satisfactorily characterized using a combination of sophisticated statistical methodologies including latent variable modeling (LVM) and generalized linear autoregressive moving average (GLARMA) time series analysis. This report provides detailed information on the available exposure data and the available health outcomes data for the construction of a comprehensive database suitable for analysis, illustrates the application of various statistical methods to characterize the relationship between health effects and exposure, and provides a road map for conducting the proposed study. In addition, a detailed work plan for conducting the study is provided and includes a list of tasks and an estimated budget. A substantial portion of the total study cost is attributed to the cost of analyzing a large number of archived PM{sub 2.5} filters. Analysis of a representative sample of the filters supports the reliability of this invaluable but as-yet untapped resource. These filters hold the key to having sufficient data on the components of PM{sub 2.5} but have a limited shelf life. If the archived filters are not analyzed promptly the important and costly information they

  10. Meeting report: 2nd workshop of the United States culture collection network (May 19-21, 2014, State College, PA, USA)

    Technology Transfer Automated Retrieval System (TEKTRAN)

    This report summarizes the activities and outcomes of the second workshop of the US Culture Collection Network, formally an activity of the US National Science Foundation sponsored Research Coordination Network for a Community of ex situ Microbial Germplasm Repositories. The workshop included presen...

  11. Supersymmetries in physics. Proceedings. 5th International Conference on Supersymmetries in Physics (SUSY 97), Philadelphia, PA (USA), 27 - 31 May 1997.

    NASA Astrophysics Data System (ADS)

    1998-03-01

    The following topics were dealt with: Experimental searches for supersymmetry, MSSM phenomenology, supergravity, grand unification, and superstring phenomenology, dark matter and cosmology, dynamical supersymmetry breaking, M-theory, black holes.

  12. Dynamics of stream nitrate sources and flow pathways during storm flows on urban, forest, and agricultural watersheds in central PA, USA

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Potential sources and flow paths of stream water nitrate were assessed using stable isotopes in nitrate (delta 15N-NO3 and delta 18O-NO3) and water (delta 18O-H2O) in Spring Creek, a 201 square-kilometer mixed land-use watershed located in central Pennsylvania. Six storm events were sampled during ...

  13. Exploring the Role of the Food Environment on Food Shopping Patterns in Philadelphia, PA, USA: A Semiquantitative Comparison of Two Matched Neighborhood Groups

    PubMed Central

    Hirsch, Jana A.; Hillier, Amy

    2013-01-01

    Increasing research has focused on the built food environment and nutrition-related outcomes, yet what constitutes a food environment and how this environment influences individual behavior still remain unclear. This study assesses whether travel mode and distance to food shopping venues differ among individuals in varying food environments and whether individual- and household-level factors are associated with food shopping patterns. Fifty neighbors who share a traditionally defined food environment (25 in an unfavorable environment and 25 in a favorable environment) were surveyed using a mix of close- and open-ended survey questions. Food shopping patterns were mapped using Geographic Information Systems (GIS). Stores visited were beyond the 0.5-mile (805 meters) radius traditionally used to represent the extent of an individual’s food environment in an urban area. We found no significant difference in shopping frequency or motivating factor behind store choice between the groups. No differences existed between the two groups for big food shopping trips. For small trips, individuals in the favorable food environment traveled shorter distances and were more likely to walk than drive. Socioeconomic status, including car ownership, education, and income influenced distance traveled. These findings highlight the complexities involved in the study and measurement of food environments. PMID:23343984

  14. Meeting report: 2nd workshop of the United States culture collection network (May 19–21, 2014, State College, PA, USA)

    PubMed Central

    2014-01-01

    This report summarizes the activities and outcomes of the second workshop of the US Culture Collection Network, formally an activity of the US National Science Foundation sponsored Research Coordination Network for a Community of ex situ Microbial Germplasm Repositories. The workshop included presentations on topics as diverse as permitting for genetically engineered plant pest organisms to facilitating strain exchange via formal material transfer agreement systems and codes of conduct. Short talks introduced diverse collections held by government, university, and private entities. Participants visited living microbe collections as well as active research and production facilities.

  15. Influence of processing sequence on the tribological properties of VGCF-X/PA6/SEBS composites

    NASA Astrophysics Data System (ADS)

    Osada, Yu; Nishitani, Yosuke; Kitano, Takeshi

    2016-03-01

    In order to develop the new tribomaterials for mechanical sliding parts with sufficient balance of mechanical and tribological properties, we investigated the influence of processing sequence on the tribological properties of the ternary nanocomposites: the polymer blends of polyamide 6 (PA6) and styrene-ethylene/butylene-styrene copolymer (SEBS) filled with vapor grown carbon fiber (VGCF-X), which is one of carbon nanofiber (CNF) and has 15nm diameter and 3μm length. Five different processing sequences: (1) VGCF-X, PA6 and SEBS were mixed simultaneously (Process A), (2) Re-mixing (Second compounding) of the materials prepared by Process A (Process AR),(3) SEBS was blended with PA6 (PA6/SEBS blends) and then these blends were mixed with VGCF-X (Process B), (4) VGCF-X was mixed with PA6 (VGCF-X/PA6 composites) and then these composites were blended with SEBS (Process C), and (5) VGCF-X were mixed with SEBS (VGCF-X/SEBS composites) and then these composites were blended with PA6 (Process D) were attempted for preparing of the ternary nanocomposites (VGCF-X/PA6/SEBS composites). These ternary polymer nanocomposites were extruded by a twin screw extruder and injection-molded. Their tribological properties were evaluated by using a ring-on-plate type sliding wear tester under dry condition. The tribological properties such as the frictional coefficient and the specific wear rate were influenced by the processing sequence. These results may be attributed to the change of internal structure formation, which is a dispersibility of SEBS particle and VGCF-X in ternary nanocomposites (VGCF-X/PA6/SEBS) by different processing sequences. In particular, the processing sequences of AR, B and D, which are those of re-mixing of VGCF-X, have a good dispersibility of VGCF-X for the improvement of tribological properties.

  16. Production of human tissue plasminogen activator (tPA) in Cucumis sativus.

    PubMed

    Asgari, Mishaneh; Javaran, Mokhtar Jalali; Moieni, Ahmad; Masoumiasl, Asad; Abdolinasab, Maryam

    2014-01-01

    Tissue plasminogen activator (tPA) as a serine protease with 72 kD molecular mass and 527 amino acids plays an important role in the fibrinolytic system and the dissolution of fibrin clots in human body. The collective production of this drug in plants such as cucumber, one of the most important vegetables in the world, could reduce its production costs. In this study, after scrutiny of the appropriate regeneration of cucumber plant (Isfahan variety) on MS medium with naphthalene acetic acid hormone (NAA; 0/1 mg L⁻¹) and benzyl amino purine hormone (BAP; 3 mg L⁻¹) hormones, the cloned human tPA gene under the CaMV 35S promoter and NOS terminator into pBI121 plasmid was transferred into cotyledon explants by Agrobacterium tumefaciens strain LBA4404. Subsequent to the regeneration of inoculated explants on the selective medium, the persistence of tPA gene in recombinant plants was confirmed by polymerase chain reaction (PCR) with specific primers. To evaluate the tPA gene expression in transgenic plants, RNA was extracted and the tPA gene transcription was confirmed by reverse-transcription (RT) PCR. Followed the extraction of protein from the leaves of transgenic plants, the presence of tPA protein was confirmed by dot blot and sodium dodecyl sulfate (SDS) polyacrylamide gel electrophoresis (PAGE) analysis in order to survey the production of recombinant tPA protein. The enzyme-linked immunosorbent assay (ELISA) test was used for recombinant tPA protein level in transgenic cucumber plants. It was counted between 0.8 and 1%, and based on this, it was concluded that the presence of three expressions of regulatory factors (CaMV 35S, Kozak, NOS) and KDEL signal in the construct caused the increase of the tPA gene expression in cucumber plants. PMID:24152103

  17. Treatment with rtPA of stroke associated with intravenous immunoglobulins perfusion.

    PubMed

    Fonseca, Ana Catarina; Geraldes, Ruth; Almeida, Vânia; Pinho e Melo, Teresa

    2011-09-15

    Information about the security of intravenous recombinant tissue type plasminogen activator (rtPA) in immunoglobulins related stroke can only be ascertained from singular cases as it was not assessed in clinical trials. Only two cases of stroke associated with IVIg treated with rtPA were described in literature. We report the outcome of two patients with IVIg associated stroke that were treated with rtPA. In our patients there were hemorrhagic complications - remote cerebral haemorrhage and diffuse cutaneous hematomas. PMID:21665226

  18. Boundary scavenging in the Pacific Ocean - A comparison of Be-10 and Pa-231

    NASA Technical Reports Server (NTRS)

    Anderson, R. F.; Lao, Y.; Broecker, W. S.; Trumbore, S. E.; Hofmann, H. J.

    1990-01-01

    Measurements of U, Th, Pa-231, and Be-10 concentrations were conducted in Holocene sediments from several sites representing open-ocean and ocean-margin environments in the Pacific Ocean. The results show that boundary scavenging plays a major role in the removal of Be-10 from the Pacific. Deposition of Be-10 is more than an order of magnitude greater at margin sites than at deep central Pacific sites, while Pa-231 is 4- to 5-fold greater at margin sites. The factors controling boundary scavenging of Pa and Be are discussed.

  19. 77 FR 29362 - Conocophillips Company, Trainer Refinery, Trainer, PA; Notice of Affirmative Determination...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-17

    ... on February 28, 2012 (77 FR 12084). The initial investigation resulted in a negative determination... Employment and Training Administration Conocophillips Company, Trainer Refinery, Trainer, PA; Notice of... former workers of ConocoPhillips Company, Trainer Refinery, Trainer, Pennsylvania (subject firm)....

  20. 76 FR 65212 - Product Dynamics LTD, Levittown, PA; Notice of Affirmative Determination Regarding Application...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-20

    ... Employment and Training Administration Product Dynamics LTD, Levittown, PA; Notice of Affirmative... apply for Trade Adjustment Assistance (TAA) applicable to workers and former workers of Product Dynamics, LTD, Levittown, Pennsylvania (Product Dynamics). The negative determination was issued on September...