Science.gov

Sample records for post authorization safety

  1. CRITICALITY SAFETY POSTING GUIDELINES

    SciTech Connect

    JENSEN, M.A.

    2001-11-01

    This document provides a set of guidelines in the preparation of criticality safety postings. Guidance is provided in word choice, word arrangement, common human factors considerations. and use of color to highlight limits, cautions, and permissives.

  2. Training in Post-authorization Pharmacovigilance.

    PubMed

    Ahuja, Vivek; Sharma, Varun

    2010-04-01

    Post-authorization pharmacovigilance refers to all the activities relating to the detection, assessment, understanding and prevention of adverse effects or any other drug-related problems, from the time a product gets the authorization to be marketed in a territory. The ultimate objective of pharmacovigilance is patient safety. To ensure this, any responsible pharmaceutical company will readily vouch for the importance of all these activities, each requiring specific training for efficient and effective execution. Having a well planned job specific training curriculum can help the organization realize its goals and objectives by covering the gaps between current and desired job performance levels and existing competencies of its employees. Apart from this, trainings can help in problem solving, increasing productivity and prepare for and respond to future changes in the organization or job duties. As the pharmaceutical business continues to grow, increasing numbers of skilled people are required to manage resultant increase in pharmacovigilance activities to remain compliant. Thus, the need for training qualified resources to develop into highly skilled pharmacovigilance professionals is the need of the hour. Currently, the supply-demand situation for skilled manpower is highly skewed in favor of the demand, as this field is relatively new in India and elsewhere. It is interesting to note that not many resources, be it internet, literature or books, are available specifically addressing the need of the industry to guide them on training requirements to set up and maintain a competent pharmacovigilance department. This article aims to present a comprehensive perspective on the trainings required in the post authorization scenario pertaining to pharmacovigilance activities and suggest ways to manage these in an efficient way so as to be compliant with the global norms and best practices. PMID:21829787

  3. 40 CFR 170.135 - Posted pesticide safety information.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...2014-07-01 2014-07-01 false Posted pesticide safety information. 170.135 Section...ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS WORKER PROTECTION STANDARD...Standard for Workers § 170.135 Posted pesticide safety information. (a)...

  4. 40 CFR 170.135 - Posted pesticide safety information.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...2012-07-01 2012-07-01 false Posted pesticide safety information. 170.135 Section...ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS WORKER PROTECTION STANDARD...Standard for Workers § 170.135 Posted pesticide safety information. (a)...

  5. 40 CFR 170.135 - Posted pesticide safety information.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...2011-07-01 2011-07-01 false Posted pesticide safety information. 170.135 Section...ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS WORKER PROTECTION STANDARD...Standard for Workers § 170.135 Posted pesticide safety information. (a)...

  6. 40 CFR 170.135 - Posted pesticide safety information.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...2013-07-01 2013-07-01 false Posted pesticide safety information. 170.135 Section...ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS WORKER PROTECTION STANDARD...Standard for Workers § 170.135 Posted pesticide safety information. (a)...

  7. 40 CFR 170.135 - Posted pesticide safety information.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...2010-07-01 2010-07-01 false Posted pesticide safety information. 170.135 Section...ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS WORKER PROTECTION STANDARD...Standard for Workers § 170.135 Posted pesticide safety information. (a)...

  8. 47 CFR 101.215 - Posting of station authorization and transmitter identification cards, plates, or signs.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Posting of station authorization and transmitter identification cards, plates, or signs. 101.215 Section 101.215 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Operational Requirements § 101.215 Posting of...

  9. 40 CFR 170.235 - Posted pesticide safety information.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...2014-07-01 2014-07-01 false Posted pesticide safety information. 170.235 Section...ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS WORKER PROTECTION STANDARD Standard for Pesticide Handlers § 170.235 Posted...

  10. 40 CFR 170.235 - Posted pesticide safety information.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...2011-07-01 2011-07-01 false Posted pesticide safety information. 170.235 Section...ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS WORKER PROTECTION STANDARD Standard for Pesticide Handlers § 170.235 Posted...

  11. 40 CFR 170.235 - Posted pesticide safety information.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...2012-07-01 2012-07-01 false Posted pesticide safety information. 170.235 Section...ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS WORKER PROTECTION STANDARD Standard for Pesticide Handlers § 170.235 Posted...

  12. 40 CFR 170.235 - Posted pesticide safety information.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...2013-07-01 2013-07-01 false Posted pesticide safety information. 170.235 Section...ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS WORKER PROTECTION STANDARD Standard for Pesticide Handlers § 170.235 Posted...

  13. 40 CFR 170.235 - Posted pesticide safety information.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...2010-07-01 2010-07-01 false Posted pesticide safety information. 170.235 Section...ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS WORKER PROTECTION STANDARD Standard for Pesticide Handlers § 170.235 Posted...

  14. 40 CFR 170.135 - Posted pesticide safety information.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 24 2011-07-01 2011-07-01 false Posted pesticide safety information. 170.135 Section 170.135 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS WORKER PROTECTION STANDARD Standard for Workers § 170.135 Posted pesticide safety information. (a) Requirement. When workers are on...

  15. 40 CFR 170.235 - Posted pesticide safety information.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 24 2011-07-01 2011-07-01 false Posted pesticide safety information. 170.235 Section 170.235 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS WORKER PROTECTION STANDARD Standard for Pesticide Handlers § 170.235 Posted pesticide safety information. (a) Requirement. When handlers...

  16. 40 CFR 170.135 - Posted pesticide safety information.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Posted pesticide safety information...) PESTICIDE PROGRAMS WORKER PROTECTION STANDARD Standard for Workers § 170.135 Posted pesticide safety..., a pesticide covered by this subpart has been applied on the establishment or a...

  17. 40 CFR 170.235 - Posted pesticide safety information.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Posted pesticide safety information...) PESTICIDE PROGRAMS WORKER PROTECTION STANDARD Standard for Pesticide Handlers § 170.235 Posted pesticide safety information. (a) Requirement. When handlers (except those employed by a commercial...

  18. NASA's post-Challenger safety program - Themes and thrusts

    NASA Technical Reports Server (NTRS)

    Rodney, G. A.

    1988-01-01

    The range of managerial, technical, and procedural initiatives implemented by NASA's post-Challenger safety program is reviewed. The recommendations made by the Rogers Commission, the NASA post-Challenger review of Shuttle design, the Congressional investigation of the accident, the National Research Council, the Aerospace Safety Advisory Panel, and NASA internal advisory panels and studies are summarized. NASA safety initiatives regarding improved organizational accountability for safety, upgraded analytical techniques and methodologies for risk assessment and management, procedural initiatives in problem reporting and corrective-action tracking, ground processing, maintenance documentation, and improved technologies are discussed. Safety issues relevant to the planned Space Station are examined.

  19. 47 CFR 101.215 - Posting of station authorization and transmitter identification cards, plates, or signs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Posting of station authorization and transmitter identification cards, plates, or signs. 101.215 Section 101.215 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES...

  20. 47 CFR 101.215 - Posting of station authorization and transmitter identification cards, plates, or signs.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 5 2013-10-01 2013-10-01 false Posting of station authorization and transmitter identification cards, plates, or signs. 101.215 Section 101.215 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES...

  1. 47 CFR 101.215 - Posting of station authorization and transmitter identification cards, plates, or signs.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 5 2012-10-01 2012-10-01 false Posting of station authorization and transmitter identification cards, plates, or signs. 101.215 Section 101.215 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES...

  2. 47 CFR 101.215 - Posting of station authorization and transmitter identification cards, plates, or signs.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false Posting of station authorization and transmitter identification cards, plates, or signs. 101.215 Section 101.215 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES...

  3. 49 CFR 390.209 - Pre-authorization safety audit.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 5 2014-10-01 2014-10-01 false Pre-authorization safety audit. 390.209 Section 390.209 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR CARRIER SAFETY REGULATIONS FEDERAL MOTOR CARRIER SAFETY REGULATIONS; GENERAL...

  4. 49 CFR 390.209 - Pre-authorization safety audit.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... MOTOR CARRIER SAFETY REGULATIONS; GENERAL Unified Registration System § 390.209 Pre-authorization safety... § 385.607(c) of this subchapter as a condition for receiving registration under this part....

  5. 49 CFR 218.61 - Authority to deactivate safety devices.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Authority to deactivate safety devices. 218.61 Section 218.61 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD OPERATING PRACTICES Prohibition Against Tampering With Safety Devices § 218.61 Authority...

  6. Post Closure Safety of the Morsleben Repository

    SciTech Connect

    Preuss, J.; Eilers, G.; Mauke, R.; Moeller-Hoeppe, N.; Engelhardt, H.-J.; Kreienmeyer, M.; Lerch, C.; Schrimpf, C.

    2002-02-26

    After the completion of detailed studies of the suitability the twin-mine Bartensleben-Marie, situated in the Federal State of Saxony-Anhalt (Germany), was chosen in 1970 for the disposal of low and medium level radioactive waste. The waste emplacement started in 1978 in rock cavities at the mine's fourth level, some 500 m below the surface. Until the end of the operational phase in 1998 in total about 36,800 m{sup 3} of radioactive waste was disposed of. The Morsleben LLW/ILW repository (ERAM) is now under licensing for closure. After completing the licensing procedure the repository will be sealed and backfilled to exclude any undue future impact onto man or the environment. The main safety objective is to protect the biosphere from the harmful effects of the disposed radionuclides. Furthermore, classical or conventional requirements call for ruling out or minimizing other unfavorable environmental effects. The ERAM is an abandoned rock salt and potash mine. As a consequence it has a big void volume, however small parts of the cavities are backfilled with crushed salt rocks. Other goals of the closure concept are therefore a long-term stabilization of the cavities to prevent a dipping or buckling of the ground surface. In addition, groundwater protection shall be assured. For the sealing of the repository a closure concept was developed to ensure compliance with the safety protection objectives. The concept anticipates the backfilling of the cavities with hydraulically setting backfill materials (salt concretes). The reduction of the remaining void volume in the mine causes in the case of brine intrusions a limitation of the leaching processes of the exposed potash seams. However, during the setting process the hydration heat of the concrete will lead to an increase of the temperature and hence to thermally induced stresses of the concrete and the surrounding rocks. Therefore, the influence of these stresses and deformations on the stability of the salt body and the integrity of the geological barrier was examined by 2D and 3D thermo-mechanical computations. The compliance of the safety objectives are proved on the basis of safety evidence criteria. It can be concluded that the closure concept is able to serve all conventional and radiological safety objectives.

  7. Efficacy and safety of darunavir (Prezista®) with low-dose ritonavir and other antiretroviral medications in subtype F HIV-1 infected, treatment-experienced subjects in Romania: a post-authorization, open-label, one-cohort, non-interventional, prospective study

    PubMed Central

    Benea, Otilia Elisabeta; Streinu-Cercel, Adrian; Dorob??, Carmen; Rugin?, Sorin; Negru?iu, Lucian; Cup?a, Augustin; Duiculescu, Dan; Chiriac, Carmen; Itu, Corina; Pris?cariu, Liviu Jany; Iosif, Ionel

    2014-01-01

    Introduction The aim of the study was to assess the safety and efficacy of darunavir (Prezista®) used in subtype F human immunodeficiency virus – type 1 (HIV-1) infected, antiretroviral therapy (ART)-experienced patients in Romania in routine clinical practice. Methods This was a post-authorization, open-label, one-cohort, non-interventional, prospective study conducted at multiple sites in Romania to assess efficacy (CD4 cell count, viral load, and treatment compliance) and safety ([serious] adverse events, clinical laboratory evaluation, and vital signs) of darunavir in combination with low-dose ritonavir (DRV/r) and other antiretroviral (ARV) medications in subtype F HIV-1 infected subjects in naturalistic settings. Seventy-eight subjects were recruited by 9 investigational sites and received 600/100 mg DRV/r twice daily. Results Treatment with DRV/r administered with other ARV medications resulted in the expected, statistically relevant improvement of CD4 cell count and viral load in subjects eligible for such treatment. In addition, adherence to treatment was high and the treatment-emergent safety profile observed during this study was consistent with the established safety profile of darunavir. Conclusion DRV/r administered in combination with other ARV medications in subtype F HIV-1 infected subjects in naturalistic settings proved to be an effective and safe treatment in Romania. Trial registration NCT01253967 PMID:25276665

  8. Research reactor operational safety improvements required by regulatory authority

    SciTech Connect

    Mikulski, A. T.

    2006-07-01

    The paper presents the activity of regulatory authority in Poland associated with improvements in operational safety of the MARIA research reactor at the Inst. of Atomic Energy at Swierk. The regulatory authority has required submission at the end of an operation cycle recorded measurements from all available detectors. These data are elaborated in order to detect any anomalies or deviations from normal operating conditions as specified in an operation licence. Also, they may be used for evaluation of technical conditions reactor components in order to improve an operational safety especially for those reactors which are operated since many years. (authors)

  9. [Recommendations for inspections of the French nuclear safety authority].

    PubMed

    Rousse, C; Chauvet, B

    2015-10-01

    The French nuclear safety authority is responsible for the control of radiation protection in radiotherapy since 2002. Controls are based on the public health and the labour codes and on the procedures defined by the controlled health care facility for its quality and safety management system according to ASN decision No. 2008-DC-0103. Inspectors verify the adequacy of the quality and safety management procedures and their implementation, and select process steps on the basis of feedback from events notified to ASN. Topics of the inspection are communicated to the facility at the launch of a campaign, which enables them to anticipate the inspectors' expectations. In cases where they are not physicians, inspectors are not allowed to access information covered by medical confidentiality. The consulted documents must therefore be expunged of any patient-identifying information. Exchanges before the inspection are intended to facilitate the provision of documents that may be consulted. Finally, exchange slots between inspectors and the local professionals must be organized. Based on improvements achieved by the health care centres and on recommendations from a joint working group of radiotherapy professionals and the nuclear safety authority, changes will be made in the control procedure that will be implemented when developing the inspection program for 2016-2019. PMID:26321685

  10. Safety studies of post-surgical buprenorphine therapy for mice.

    PubMed

    Traul, Karl A; Romero, Jennell B; Brayton, Cory; DeTolla, Louis; Forbes-McBean, Nadine; Halquist, Matthew S; Karnes, H Thomas; Sarabia-Estrada, Rachel; Tomlinson, Michael J; Tyler, Betty M; Ye, Xiaobu; Zadnik, Patricia; Guarnieri, Michael

    2015-04-01

    The use of appropriate analgesia in laboratory mice may be suboptimal because of concerns about adverse events (AE). Target Animal Safety trials were conducted to determine the safety of an extended-release suspension of buprenorphine. Drug or control suspensions were injected subcutaneously in surgically-treated BALB/c mice anesthetized with ketamine-xylazine to mimic post-operative conditions in which the compound might commonly be administered. Single and repeat five-fold (5×) excesses of the 3.25 mg/kg intended dose were used to provoke potential AE. Trials included prospective measurements of weight changes, blood chemistry, hematology, and histopathology. Clinical and histopathology findings were similar in drug-treated and control mice in a four-day trial using a single 16.25 mg/kg, 5× overdose of the drug. In a 12-day trial, which used a total buprenorphine dose of 48.75 mg/kg, clinical and histopathology values were also similar in control and drug-treated female mice. In the male arm of the repeat-overdose trial, two of eight mice died on the morning of day 12, three days following the third 16.25 mg/kg overdose administration. Histopathology did not reveal a cause of death. In a 14-month trial using a single 3.25 mg/kg dose of the drug, no significant findings identified potential AE. These findings indicate a high tolerance to an extended-release buprenorphine suspension administered post-operatively in mice with appropriate husbandry. PMID:25305141

  11. DARHT: INTEGRATION OF AUTHORIZATION BASIS REQUIREMENTS AND WORKER SAFETY

    SciTech Connect

    D. A. MC CLURE; C. A. NELSON; R. L. BOUDRIE

    2001-04-01

    This document describes the results of consensus agreements reached by the DARHT Safety Planning Team during the development of the update of the DARHT Safety Analysis Document (SAD). The SAD is one of the Authorization Basis (AB) Documents required by the Department prior to granting approval to operate the DARHT Facility. The DARHT Safety Planning Team is lead by Mr. Joel A. Baca of the Department of Energy Albuquerque Operations Office (DOE/AL). Team membership is drawn from the Department of Energy Albuquerque Operations Office, the Department of Energy Los Alamos Area Office (DOE/LAAO), and several divisions of the Los Alamos National Laboratory. Revision 1 of the DARHT SAD had been written as part of the process for gaining approval to operate the Phase 1 (First Axis) Accelerator. Early in the planning stage for the required update of the SAD for the approval to operate both Phase 1 and Phase 2 (First Axis and Second Axis) DARHT Accelerator, it was discovered that a conflict existed between the Laboratory approach to describing the management of facility and worker safety.

  12. Reevaluating nuclear safety and security in a post 9/11 era.

    SciTech Connect

    Booker, Paul M.; Brown, Lisa M.

    2005-07-01

    This report has the following topics: (1) Changing perspectives on nuclear safety and security; (2) Evolving needs in a post-9/11 era; (3) Nuclear Weapons--An attractive terrorist target; (4) The case for increased safety; (5) Evolution of current nuclear weapons safety and security; (6) Integrated surety; (7) The role of safety and security in enabling responsiveness; (8) Advances in surety technologies; and (9) Reevaluating safety.

  13. 40 CFR 170.135 - Posted pesticide safety information.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., pesticide safety information. (b) Pesticide safety poster. A safety poster must be displayed that conveys..., and telephone number of the nearest emergency medical care facility shall be on the safety poster or displayed close to the safety poster. (2) The agricultural employer shall inform workers promptly of...

  14. 40 CFR 170.135 - Posted pesticide safety information.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., pesticide safety information. (b) Pesticide safety poster. A safety poster must be displayed that conveys..., and telephone number of the nearest emergency medical care facility shall be on the safety poster or displayed close to the safety poster. (2) The agricultural employer shall inform workers promptly of...

  15. 40 CFR 170.135 - Posted pesticide safety information.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., pesticide safety information. (b) Pesticide safety poster. A safety poster must be displayed that conveys..., and telephone number of the nearest emergency medical care facility shall be on the safety poster or displayed close to the safety poster. (2) The agricultural employer shall inform workers promptly of...

  16. 40 CFR 170.235 - Posted pesticide safety information.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    .... (b) Pesticide safety poster. A safety poster must be displayed that conveys, at a minimum, the... the nearest emergency medical care facility shall be on the safety poster or displayed close to the safety poster. (2) The handler employer shall inform handlers promptly of any change to the...

  17. 40 CFR 170.235 - Posted pesticide safety information.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    .... (b) Pesticide safety poster. A safety poster must be displayed that conveys, at a minimum, the... the nearest emergency medical care facility shall be on the safety poster or displayed close to the safety poster. (2) The handler employer shall inform handlers promptly of any change to the...

  18. 40 CFR 170.235 - Posted pesticide safety information.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    .... (b) Pesticide safety poster. A safety poster must be displayed that conveys, at a minimum, the... the nearest emergency medical care facility shall be on the safety poster or displayed close to the safety poster. (2) The handler employer shall inform handlers promptly of any change to the...

  19. The safety of liposome bupivacaine 2 years post-launch: a look back and a look forward.

    PubMed

    Viscusi, Eugene R

    2015-12-01

    The need for better post-surgical pain management continues to be unmet, despite clinicians' awareness and concern for many years. Opioids remain the standard of care because of their analgesic efficacy; however, opioid use is often associated with adverse effects and poor patient outcomes. Multimodal analgesic regimens have recently been endorsed as a way to provide adequate post-surgical pain control while reducing opioid consumption. Liposome bupivacaine is a liposomal formulation of bupivacaine indicated for a single administration into the surgical site. Based on the available clinical trial data compiled to date, as well as the author's review of publicly available post-marketing safety information, liposome bupivacaine may be a viable addition to currently available therapeutic options for post-surgical analgesia while reducing potential risks associated with use of opioid analgesics, and may represent a useful addition to the multimodal analgesic modalities currently used for post-operative pain management. The potential for its use in other areas is also being investigated. The purpose of this review is to examine the currently available post-marketing safety information on liposome bupivacaine. PMID:26436689

  20. the Occupational Safety & Health Administration (OSHA) has the authority to conduct inspections of

    E-print Network

    Nizkorodov, Sergey

    the Occupational Safety & Health Administration (OSHA) has the authority to conduct inspections of the agency's current enforcement-heavy philosophy. the Occupational Safety & Health Administration (OSHASIDErAtIOnS #12;Develop and implement a Comprehensive Safety and Health Program » Ensure written safety programs

  1. 30 CFR 774.11 - Post-permit issuance requirements for regulatory authorities and other actions based on ownership...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...Post-permit issuance requirements for regulatory authorities and other actions based...PERMITS AND COAL EXPLORATION SYSTEMS UNDER REGULATORY PROGRAMS REVISION; RENEWAL; TRANSFER...Post-permit issuance requirements for regulatory authorities and other actions...

  2. 30 CFR 774.11 - Post-permit issuance requirements for regulatory authorities and other actions based on ownership...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...Post-permit issuance requirements for regulatory authorities and other actions based...PERMITS AND COAL EXPLORATION SYSTEMS UNDER REGULATORY PROGRAMS REVISION; RENEWAL; TRANSFER...Post-permit issuance requirements for regulatory authorities and other actions...

  3. 30 CFR 774.11 - Post-permit issuance requirements for regulatory authorities and other actions based on ownership...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...Post-permit issuance requirements for regulatory authorities and other actions based...PERMITS AND COAL EXPLORATION SYSTEMS UNDER REGULATORY PROGRAMS REVISION; RENEWAL; TRANSFER...Post-permit issuance requirements for regulatory authorities and other actions...

  4. 30 CFR 774.11 - Post-permit issuance requirements for regulatory authorities and other actions based on ownership...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...Post-permit issuance requirements for regulatory authorities and other actions based...PERMITS AND COAL EXPLORATION SYSTEMS UNDER REGULATORY PROGRAMS REVISION; RENEWAL; TRANSFER...Post-permit issuance requirements for regulatory authorities and other actions...

  5. 30 CFR 774.11 - Post-permit issuance requirements for regulatory authorities and other actions based on ownership...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...Post-permit issuance requirements for regulatory authorities and other actions based...PERMITS AND COAL EXPLORATION SYSTEMS UNDER REGULATORY PROGRAMS REVISION; RENEWAL; TRANSFER...Post-permit issuance requirements for regulatory authorities and other actions...

  6. Morganza to the Gulf of Mexico, Louisiana Post Authorization Change Report and

    E-print Network

    US Army Corps of Engineers

    #12;1 Morganza to the Gulf of Mexico, Louisiana Post Authorization Change Report and Revised of Mexico, Louisiana (Morganza to the Gulf) hurricane and storm damage reduction project for construction of the Chief of Engineers updating the authorized Morganza to the Gulf of Mexico project. The Louisiana Coastal

  7. SheetEnvironment, Health and Safety Information for the Berkeley Campus Please post or circulate

    E-print Network

    Cohen, Ronald C.

    ) 642-3073 Revised 08/01/12 Formaldehyde: Hazards and Precautions Health hazards Eye and skin exposureSheetEnvironment, Health and Safety Information for the Berkeley Campus No. 49 Fact Please post or circulate EH&S U C B E R K E L E YU C B E R K E L E Y HH SS&& EE Office of Environment, Health & Safety

  8. SheetEnvironment, Health and Safety Information for the Berkeley Campus Please post or circulate

    E-print Network

    Yaghi, Omar M.

    SheetEnvironment, Health and Safety Information for the Berkeley Campus No.84 Fact Please post) 642-3073 Revised 4/22/13 Air Quality Odors Affecting Your Workplace Problem odors indoors are among tablespoons of mineral oil to float on drain water to minimize the trap water from evaporating. · Lost

  9. 77 FR 28566 - Notice of Request for a New Information Collection (Food Safety Education Campaign-Post-Wave...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-15

    ...In accordance with the Paperwork Reduction Act of 1995 and the Office of Management and Budget (OMB) regulations, the Food Safety and Inspection Service (FSIS) is announcing its intention to request a new information collection for a post-wave tracking survey associated with the Food Safety Education Campaign. The post-wave survey is conducted after the initial tracking survey is completed,......

  10. 30 CFR 75.363 - Hazardous conditions and violations of mandatory health or safety standards; posting, correcting...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... mandatory health or safety standards; posting, correcting, and recording. (a) Any hazardous condition found... correct or evaluate the hazardous condition may enter the posted area. Any violation of a mandatory health... which the hazardous condition or violation of the nine mandatory health or safety standards is found...

  11. 30 CFR 75.363 - Hazardous conditions and violations of mandatory health or safety standards; posting, correcting...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... mandatory health or safety standards; posting, correcting, and recording. (a) Any hazardous condition found... correct or evaluate the hazardous condition may enter the posted area. Any violation of a mandatory health... which the hazardous condition or violation of the nine mandatory health or safety standards is found...

  12. Authorization Basis Safety Classification of Transfer Bay Bridge Crane at the 105-K Basins

    SciTech Connect

    CHAFFEE, G.A.

    2000-04-06

    This supporting document provides the bases for the safety classification for the K Basin transfer bay bridge crane and the bases for the Structures, Systems, and Components (SSC) safety classification. A table is presented that delineates the safety significant components. This safety classification is based on a review of the Authorization Basis (AB). This Authorization Basis review was performed regarding AB and design baseline issues. The primary issues are: (1) What is the AB for the safety classification of the transfer bay bridge crane? (2) What does the SSC safety classification ''Safety Significant'' or ''Safety Significant for Design Only'' mean for design requirements and quality requirements for procurement, installation and maintenance (including replacement of parts) activities for the crane during its expected life time? The AB information on the crane was identified based on review of Department of Energy--Richland Office (RL) and Spent Nuclear Fuel (SNF) Project correspondence, K Basin Safety Analysis Report (SAR) and RL Safety Evaluation Reports (SERs) of SNF Project SAR submittals. The relevant correspondence, actions and activities taken and substantive directions or conclusions of these documents are provided in Appendix A.

  13. Procedure-Authoring Tool Improves Safety on Oil Rigs

    NASA Technical Reports Server (NTRS)

    2014-01-01

    Dark, cold, and dangerous environments are plentiful in space and on Earth. To ensure safe operations in difficult surroundings, NASA relies heavily on procedures written well ahead of time. Houston-based TRACLabs Inc. worked with Ames Research Center through the SBIR program to create an electronic procedure authoring tool, now used by NASA and companies in the oil and gas industry.

  14. Status of High Flux Isotope Reactor (HFIR) post-restart safety analysis and documentation upgrades

    SciTech Connect

    Cook, D.H.; Radcliff, T.D.; Rothrock, R.B.; Schreiber, R.E.

    1990-01-01

    The High Flux Isotope Reactor (HFIR), an experimental reactor located at the Oak Ridge National Laboratory (ORNL) and operated for the US Department of Energy by Martin Marietta Energy Systems, was shut down in November, 1986 after the discovery of unexpected neutron embrittlement of the reactor vessel. The reactor was restarted in April, 1989, following an extensive review by DOE and ORNL of the HFIR design, safety, operation, maintenance and management, and the implementation of several upgrades to HFIR safety-related hardware, analyses, documents and procedures. This included establishing new operating conditions to provide added margin against pressure vessel failure, as well as the addition, or upgrading, of specific safety-related hardware. This paper summarizes the status of some of the follow-on (post-restart) activities which are currently in progress, and which will result in a comprehensive set of safety analyses and documentation for the HFIR, comparable with current practice in commercial nuclear power plants. 8 refs.

  15. 77 FR 64374 - Notification of Petition for Approval; Port Authority Trans-Hudson Product Safety Plan

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-19

    ...FRA-2012-0075] Notification of Petition for Approval; Port Authority Trans- Hudson Product Safety Plan In accordance with Part 236 of...that by a document dated September 5, 2012, Port Authority Trans-Hudson (PATH) has petitioned the Federal Railroad...

  16. 48 CFR 50.205-3 - Authorization of offers contingent upon SAFETY Act designation or certification before contract...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... EXTRAORDINARY CONTRACTUAL ACTIONS AND THE SAFETY ACT Support Anti-terrorism by Fostering Effective Technologies Act of 2002 50.205-3 Authorization of offers contingent upon SAFETY Act designation or certification before contract award....

  17. 7 CFR 735.10 - Posting of certificates of licensing, certificates of authorization or other USWA documents.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE REGULATIONS FOR WAREHOUSES REGULATIONS FOR THE UNITED STATES WAREHOUSE ACT General Provisions § 735.10 Posting of certificates of licensing, certificates of authorization or other USWA documents. (a) The warehouse operator must post, in a...

  18. 7 CFR 735.10 - Posting of certificates of licensing, certificates of authorization or other USWA documents.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE REGULATIONS FOR WAREHOUSES REGULATIONS FOR THE UNITED STATES WAREHOUSE ACT General Provisions § 735.10 Posting of certificates of licensing, certificates of authorization or other USWA documents. (a) The warehouse operator must post, in a...

  19. Scientific Method and the Regulation of Health and Nutritional Claims by the European Food Safety Authority

    ERIC Educational Resources Information Center

    Hoad, Darren

    2011-01-01

    The protection of European consumers from the false or misleading scientific and nutritional claims of food manufacturers took a step forward with the recent opinions of the European Food Safety Authority (EFSA). As a risk assessment agency, the EFSA recently assessed and rejected a vast number of food claim forcing the withdrawal of many claims…

  20. Post-marketing surveillance of live-attenuated Japanese encephalitis vaccine safety in China.

    PubMed

    Wang, Yali; Dong, Duo; Cheng, Gang; Zuo, Shuyan; Liu, Dawei; Du, Xiaoxi

    2014-10-01

    Japanese encephalitis (JE) is the most severe form of viral encephalitis in Asia and no specific treatment is available. Vaccination provides an effective intervention to prevent JE. In this paper, surveillance data for adverse events following immunization (AEFI) related to SA-14-14-2 live-attenuated Japanese encephalitis vaccine (Chengdu Institute of Biological Products) was presented. This information has been routinely generated by the Chinese national surveillance system for the period 2009-2012. There were 6024 AEFI cases (estimated reported rate 96.55 per million doses). Most common symptoms of adverse events were fever, redness, induration and skin rash. There were 70 serious AEFI cases (1.12 per million doses), including 9 cases of meningoencephalitis and 4 cases of death. The post-marketing surveillance data add the evidence that the Chengdu institute live attenutated vaccine has a reasonable safety profile. The relationship between encephalitis and SA-14-14-2 vaccination should be further studied. PMID:25173477

  1. Safety of post-operative epidural analgesia in the paediatric population: A retrospective analysis

    PubMed Central

    Kasanavesi, Ramakrishna Chaitanya; Gazula, Suhasini; Pula, Ravikanth; Thakur, Nagarjuna

    2015-01-01

    Background and Aims: Epidural infusion analgesia (EIA) is among the common procedures performed in children to provide analgesia. However, the administration of epidural is not without complications. Limited studies are available regarding the safety of EIA in children with no studies from the Indian subcontinent. The aim of this study was to analyse all the complications that occured during administration and maintenance of EIA in paediatric patients. Methods: All children undergoing elective or emergency surgeries under general anaesthesia and given concomitant epidural analgesia for post-operative pain management were included. Data were collected by reviewing patient medical records, anaesthesia registers and post-operative intensive care unit charts. Statistical averages were drawn to assess the complication rates. Results: Seventy children received epidural analgesia during the span of study, of them five were neonates and fifteen were infants. No major complications that were life-threatening or leading to permanent disability were documented. Two children (2.85%) had blood tap during procedure. Eleven children (15%) had peri-catheter leaks and 14 children (20%) had catheter dislodgements. Conclusion: EIA seems to be a relatively safe method of providing analgesia. It is associated with the occurrence of complications which are at best temporary.

  2. Efficacy and Safety of the Angioseal Vascular Closure Device Post Antegrade Puncture

    SciTech Connect

    Looby, S.; Keeling, A. N.; McErlean, A.; Given, M. F.; Geoghegan, T.; Lee, M. J.

    2008-05-15

    In this study, the efficacy and safety of the Angioseal vascular closure device post antegrade puncture of the common femoral artery (CFA) for lower limb vascular interventional procedures are evaluated. A retrospective analysis of the medical records of 60 consecutive patients who were referred for interventional procedures in the superficial femoral artery (SFA) or popliteal artery (popl. art.) was performed. Antegrade puncture was successfully performed in 58 of 60 patients (96.6%). Indications included right SFA angioplasty (n = 35), left SFA angioplasty (n = 17), right popl. art. angioplasty (n = 5), and left popl. art. angioplasty (n = 1). Hemostasis was achieved by, on an intention-to-treat basis, the Angioseal vascular closure device in 46 patients and manual compression in 12 patients. Manual compression was used instead of Angioseal because of severe calcified arterial wall plaques (n = 7), failed deployment of the Angioseal (n = 4), and left SFA dissection (n = 1). There were no major recorded complications in the Angioseal group despite the use of antiplatelet or anticoagulant medications. Twenty-three (50%) of the patients in the Angioseal group were discharged within 24 h. Thirty-seven of the 46 patients who received an Angioseal device had undergone a previous ipsilateral CFA puncture (time range, 2 days to 56 months; mean, 6.2 months). Nine of these patients had undergone ipsilateral Angioseal deployment in the previous 3 months. We conclude that the Angioseal vascular closure device is a safe and efficient means of achieving hemostasis post antegrade puncture.

  3. Safety and acceptability of post-abortal IUD insertion and the importance of counseling.

    PubMed

    El-Tagy, Ahmed; Sakr, Ezzat; Sokal, David C; Issa, Adel Hakim

    2003-03-01

    This nonrandomized observational clinical study evaluated the safety and acceptability of intrauterine device insertion either immediately or 2 weeks after abortion, according to the patient's preference. Participants were 300 women with first-trimester abortions who agreed to immediate or delayed insertion. End points were bleeding patterns, pregnancy, expulsion, perforation, infection and device removal at 2, 6 and 10 weeks after insertion, and acceptance rates before and after counseling procedures were improved. The overall initial acceptance rate was 35.8%, and the actual acceptance rate was 31.7%. After counseling procedures were improved, the initial and actual acceptance rates increased substantially (17.7% vs. 44.3% and 10.2% vs. 42.0%, respectively). Bleeding, expulsion rates and pain did not differ significantly between the immediate and delayed insertion groups after IUD insertion. No pregnancies, perforations or cases of pelvic inflammatory disease were recorded in either group. Immediate post-abortal insertion offers the advantage of being a painless procedure. The quality of counseling is critical to improving acceptance of post-abortion contraception. PMID:12618259

  4. Safe Physical Activity Environments--To What Extent Are Local Government Authorities Auditing the Safety of Grassed Sporting Grounds?

    ERIC Educational Resources Information Center

    Otago, Leonie; Swan, Peter; Donaldson, Alex; Payne, Warren; Finch, Caroline

    2009-01-01

    Physical activity (PA) participation is influenced by the safety of the settings in which it is undertaken. This study describes the grounds assessment practices of Local Government Authorities (LGAs) in Victoria, Australia to ensure the safety of grassed sporting grounds. It also makes recommendations for improving these practices to maximise the…

  5. Safety of inhaled glycopyrronium in patients with COPD: a comprehensive analysis of clinical studies and post-marketing data

    PubMed Central

    D’Urzo, Anthony D; Kerwin, Edward M; Chapman, Kenneth R; Decramer, Marc; DiGiovanni, Robert; D’Andrea, Peter; Hu, Huilin; Goyal, Pankaj; Altman, Pablo

    2015-01-01

    Background Chronic use of inhaled anticholinergics by patients with chronic obstructive pulmonary disease (COPD) has raised long-term safety concerns, particularly cardiovascular. Glycopyrronium is a once-daily anticholinergic with greater receptor selectivity than previously available agents. Methods We assessed the safety of inhaled glycopyrronium using data pooled from two analysis sets, involving six clinical studies and over 4,000 patients with COPD who received one of the following treatments: glycopyrronium 50?g, placebo (both delivered via the Breezhaler® device), or tiotropium 18 ?g (delivered via the HandiHaler® device). Data were pooled from studies that varied in their duration and severity of COPD of the patients (ie, ?12 weeks duration with patients having moderate or severe COPD; and >1 year duration with patients having severe and very severe COPD). Safety comparisons were made for glycopyrronium vs tiotropium or placebo. Poisson regression was used to assess the relative risk for either active drug or placebo (and between drugs where placebo was not available) for assessing the incidence of safety events. During post-marketing surveillance (PMS), safety was assessed by obtaining reports from various sources, and disproportionality scores were computed using EMPIRICA™. In particular, the cardiac safety of glycopyrronium during the post-marketing phase was evaluated. Results The overall incidence of adverse events and deaths was similar across groups, while the incidence of serious adverse events was numerically higher in placebo. Furthermore, glycopyrronium did not result in an increased risk of cerebro-cardiovascular events vs placebo. There were no new safety reports during the PMS phase that suggested an increased risk compared to results from the clinical studies. Moreover, the cardiac safety of glycopyrronium during the PMS phase was also consistent with the clinical data. Conclusion The overall safety profile of glycopyrronium was similar to its comparators indicating no increase in the overall risk for any of the investigated safety end points. PMID:26316734

  6. Drug packaging in 2014: authorities should direct more efforts towards medication safety.

    PubMed

    2015-05-01

    In 2014, Prescrire examined the packaging quality of about 250 drugs. A few advances stand out, mainly involving recent drugs, but on the whole, the situation is worrisome in terms of medication safety. Although pharmaceutical companies and drug regulatory agencies seem to be taking more account of the risk of accidental poisoning in children, the level of protection remains low overall in the absence of stringent measures on the part of the authorities. New drugs too often have poor-quality or even dangerous packaging at the time of their market introduction. And the packaging quality of older drugs is disturbing. Pharmaceutical companies no longer invest in the packaging of these products, and agencies often fail to take advantage of the opportunities provided by their reassessment to improve the situation. The inappropriate labelling of certain injectable drugs remains a source of medication errors, sometimes resulting in very serious consequences. In 2014, signs of progress in the packaging of several drugs show that its role in medication safety is better appreciated. But the persistence of dangers in the pharmaceuticals market, created by "unfinished", overly complex or poor-quality packaging, raises the question of the responsibility of pharmaceutical companies and agencies for past and present accidents. PMID:26034808

  7. Assessment of the safety of US nuclear weapons and related nuclear test requirements: A post-Bush Initiative update

    SciTech Connect

    Kidder, R.E.

    1991-12-10

    The Nuclear Weapons Reduction Initiative announced by President Bush on September 27, 1991, is described herein as set forth in Defense Secretary Cheney`s Nuclear Arsenal Reduction Order issued September 28, 1991. The implications of the Bush Initiative for improved nuclear weapons safety are assessed in response to a request by US Senators Harkin, Kennedy, and Wirth to the Lawrence Livermore National Laboratory that the author prepare such an assessment. The author provides an estimate of the number of nuclear tests needed to accomplish a variety of specified warhead safety upgrades, then uses the results of this estimate to answer three questions posed by the Senators. These questions concern pit reuse and the number of nuclear tests needed for specified safety upgrades of those ballistic missiles not scheduled for retirement, namely the Minuteman III, C4, and D5 missiles.

  8. 77 FR 28451 - Unsatisfactory Safety Rating; Revocation of Operating Authority Registration; Technical Amendments

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-14

    ...carrier for failure to comply with safety fitness requirements; if the Agency determines...carrier is ``Unfit'' based on its Safety Fitness Determination procedures, the Agency...commerce for failure to comply with safety fitness requirements. See 49 U.S.C....

  9. Will They Ever Speak with Authority? Race, Post-Coloniality and the Symbolic Violence of Language

    ERIC Educational Resources Information Center

    Ibrahim, Awad

    2011-01-01

    Intersecting authority-language-and-symbolic power, this article tells the story of a group of continental Francophone African youth who find themselves in an urban French-language high school in southwestern Ontario, Canada. Through their narrative, one is confronted by the trauma of one's own language being declared an illegitimate child, hence…

  10. Back to the Future: Leadership, Tradition, and Authority in a Post-Critical Age

    ERIC Educational Resources Information Center

    Hawkins, Andrew

    2010-01-01

    Both modern and postmodern approaches to knowledge view tradition and authority with suspicion, even contempt, though each approach does so in different ways. Our profession vacillates between those epistemological orientations, struggling to find direction and meaning. Leadership, in particular, is in a quandary; what does leadership look like in…

  11. Further Education outside the Jurisdiction of Local Education Authorities in Post-War England

    ERIC Educational Resources Information Center

    Simmons, Robin

    2014-01-01

    This article revisits the three decades following the end of World War Two--a time when, following the 1944 Education Act, local education authorities (LEAs) were the key agencies responsible for running the education system across England. For the first time, there was a statutory requirement for LEAs to secure adequate facilities for further…

  12. *Corresponding author. Fax: #972-3-642-2979. E-mail address: bergman@post.tau.ac.il (D.J. Bergman)

    E-print Network

    Strelniker, Yakov M.

    *Corresponding author. Fax: #972-3-642-2979. E-mail address: bergman@post.tau.ac.il (D.J. Bergman-dimensional microstructure David J. Bergman*, Yakov M. Strelniker School of Physics and Astronomy, Raymond and Beverly

  13. Approaches in the risk assessment of genetically modified foods by the Hellenic Food Safety Authority.

    PubMed

    Varzakas, Theodoros H; Chryssochoidis, G; Argyropoulos, D

    2007-04-01

    Risk analysis has become important to assess conditions and take decisions on control procedures. In this context it is considered a prerequisite in the evaluation of GM food. Many consumers worldwide worry that food derived from genetically modified organisms (GMOs) may be unhealthy and hence regulations on GMO authorisations and labelling have become more stringent. Nowadays there is a higher demand for non-GM products and these products could be differentiated from GM products using the identity preservation system (IP) that could apply throughout the grain processing system. IP is the creation of a transparent communication system that encompasses HACCP, traceability and related systems in the supply chain. This process guarantees that certain characteristics of the lots of food (non-GM origin) are maintained "from farm to fork". This article examines the steps taken by the Hellenic Food Safety Authority to examine the presence of GMOs in foods. The whole integrated European legislation framework currently in place still needs to be implemented in Greece. Penalties should be enforced to those who import, process GMOs without special licence and do not label those products. Similar penalties should be enforced to those companies that issue false certificates beyond the liabilities taken by the food enterprises for farmers' compensation. We argue that Greece has no serious reasons to choose the use of GMOs due to the fact that the structural and pedologic characteristics of the Greek agriculture favour the biological and integrated cultivation more. Greece is not in favour of the politics behind coexistence of conventional and GM plants and objects to the use of GMOs in the food and the environment because the processor has a big burden in terms of money, time and will suffer a great deal in order to prove that their products are GMO free or that any contamination is adventitious or technically unavoidable. Moreover, Greece owns a large variety of genetic material that should try to protect from patenting and commercialisation. Finally, we should be aware of the requirements of movement of GMOs within borders, i.e. GMOs grown or used in other countries but which are not intended to cross into Greece, since Greece is very close to countries that are non-EU. This is where the development of a new, integrated, trustworthy and transparent food quality control system will help to satisfy the societal demands for safe and quality products. On the other hand, Greece should not be isolated from any recent scientific technological development and should assess the possible advantages for some cultivation using a case by case approach. Finally, the safety assessment of GM foods and feed has been discussed according to the risk assessment methodology applied by EFSA. PMID:17275157

  14. 10 CFR 35.57 - Training for experienced Radiation Safety Officer, teletherapy or medical physicist, authorized...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...or medical physicist, authorized medical physicist, authorized user, nuclear pharmacist, and authorized nuclear pharmacist. 35.57 Section 35.57 Energy NUCLEAR REGULATORY COMMISSION MEDICAL USE OF BYPRODUCT MATERIAL General...

  15. 10 CFR 35.57 - Training for experienced Radiation Safety Officer, teletherapy or medical physicist, authorized...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...or medical physicist, authorized medical physicist, authorized user, nuclear pharmacist, and authorized nuclear pharmacist. 35.57 Section 35.57 Energy NUCLEAR REGULATORY COMMISSION MEDICAL USE OF BYPRODUCT MATERIAL General...

  16. 10 CFR 35.57 - Training for experienced Radiation Safety Officer, teletherapy or medical physicist, authorized...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...or medical physicist, authorized medical physicist, authorized user, nuclear pharmacist, and authorized nuclear pharmacist. 35.57 Section 35.57 Energy NUCLEAR REGULATORY COMMISSION MEDICAL USE OF BYPRODUCT MATERIAL General...

  17. 10 CFR 35.57 - Training for experienced Radiation Safety Officer, teletherapy or medical physicist, authorized...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...or medical physicist, authorized medical physicist, authorized user, nuclear pharmacist, and authorized nuclear pharmacist. 35.57 Section 35.57 Energy NUCLEAR REGULATORY COMMISSION MEDICAL USE OF BYPRODUCT MATERIAL General...

  18. 10 CFR 35.57 - Training for experienced Radiation Safety Officer, teletherapy or medical physicist, authorized...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...or medical physicist, authorized medical physicist, authorized user, nuclear pharmacist, and authorized nuclear pharmacist. 35.57 Section 35.57 Energy NUCLEAR REGULATORY COMMISSION MEDICAL USE OF BYPRODUCT MATERIAL General...

  19. Environment, Health and Safety Information for the Berkeley Campus Please post or circulate

    E-print Network

    Cohen, Ronald C.

    through the protective glass sashes on fume hoods. Minimize postings and writing on sashes. - Containers radioactive materials are to be clearly marked with radiation tape and sorbent pads. - All spills

  20. Antiterrorism design and public safety : reconciling CPTED with the post-9/11 city

    E-print Network

    Rothrock, Sara E. (Sara Elizabeth)

    2010-01-01

    Urban downtowns have changed since September 1 1, 2001, sprouting bollards, planters, and barriers installed on the pretense of improved safety and security. While these interventions protect buildings from vehicle bombs, ...

  1. Environment, Health and Safety Information for the Berkeley Campus Please post or circulate

    E-print Network

    Cohen, Ronald C.

    or circulate EH&S U C B E R K E L E YU C B E R K E L E Y HH SS&& EE Office of Environment, Health & Safety relatively small areas. Ingestion of as little as 1 gram can be fatal to humans. Phenol can also cause severe Y HH SS&& EE Office of Environment, Health & Safety · University of California · 317 University Hall

  2. Index to Nuclear Safety: a technical progress review by chronology, permuted title, and author, Volume 18 (1) through Volume 22 (6)

    SciTech Connect

    Cottrell, W.B.; Passiakos, M.

    1982-06-01

    This index to Nuclear Safety covers articles published in Nuclear Safety, Volume 18, Number 1 (January-February 1977) through Volume 22, Number 6 (November-December 1981). The index is divided into three section: a chronological list of articles (including abstracts), a permuted-title (KWIC) index, and an author index. Nuclear Safety, a bimonthly technical progress review prepared by the Nuclear Safety Information Center, covers all safety aspects of nuclear power reactors and associated facilities. Over 300 technical articles published in Nuclear Safety in the last 5 years are listed in this index.

  3. [Hysterectomy to stop bleeding in obstetrics. Are there still indications for performing hysterectomy immediately post-partum? (author's transl)].

    PubMed

    Boisselier, P; Pigne, A; Jouhet, P; Treisser, A; Delubac, D; Barrat, J

    1981-01-01

    13 cases of hysterectomy carried out to stop bleeding immediately after delivery have been studied. Among these there were : 5 cases of placenta accreta which confirmed histologically. 4 cases of uterine inertia. 2 cases of failure of coagulation, one of which occurred after there had been a retro-placental haematoma and 2 ruptured uteri. After analysing the clinical circumstances surrounding these 13 cases and the technical details in carrying out hysterectomy on the gravid uterus, the authors studied conservative surgical measures that could be used to deal with post-partum uterine haemorrhage : the hypogastric arteries on the one hand the efferent arteries supplying the uterus on the other hand can be ligated. The technique for this last procedure is illustrated in one case. PMID:6976365

  4. State Regulatory Authority (SRA) Coordination of Safety, Security, and Safeguards of Nuclear Facilities: A Framework for Analysis

    SciTech Connect

    Mladineo, Stephen V.; Frazar, Sarah L.; Kurzrok, Andrew J.; Martikka, Elina; Hack, Tapani; Wiander, Timo

    2013-05-30

    This paper will explore the development of a framework for conducting an assessment of safety-security-safeguards integration within a State. The goal is to examine State regulatory structures to identify conflicts and gaps that hinder management of the three disciplines at nuclear facilities. Such an analysis could be performed by a State Regulatory Authority (SRA) to provide a self-assessment or as part of technical cooperation with either a newcomer State, or to a State with a fully developed SRA.

  5. Improving Post-Approval Drug Safety Surveillance: Getting Better Information Sooner

    PubMed Central

    Hennessy, Sean; Strom, Brian L.

    2015-01-01

    Adverse drug events (ADEs) are an important public health concern, accounting for 5% of all hospital admissions and two-thirds of all complications occurring shortly after hospital discharge. There are often long delays between when a drug is approved and when serious ADEs are identified. Recent and ongoing advances in drug safety surveillance include establishment of government-sponsored networks of population databases, use of data mining approaches, and formal integration of diverse sources of drug safety information. These advances promise to reduce delays in identifying drug-related risks, allowing earlier identification of risks as well as reassurance about the absence of specific risks. PMID:25292435

  6. Incentivizing Primary Care Providers to Innovate: Building Medical Homes in the Post-Katrina New Orleans Safety Net

    PubMed Central

    Rittenhouse, Diane R; Schmidt, Laura A; Wu, Kevin J; Wiley, James

    2014-01-01

    ObjectiveTo evaluate safety-net clinics’ responses to a novel community-wide Patient-Centered Medical Home (PCMH) financial incentive program in post-Katrina New Orleans. Data Sources/Study SettingBetween June 2008 and June 2010, we studied 50 primary care clinics in New Orleans receiving federal funds to expand services and improve care delivery. Study DesignMultiwave, longitudinal, observational study of a local safety-net primary care system. Data CollectionClinic-level data from a semiannual survey of clinic leaders (89.3 percent response rate), augmented by administrative records. Principal FindingsOverall, 62 percent of the clinics responded to financial incentives by achieving PCMH recognition from the National Committee on Quality Assurance (NCQA). Higher patient volume, higher baseline PCMH scores, and type of ownership were significant predictors of achieving NCQA recognition. The steepest increase in adoption of PCMH processes occurred among clinics achieving the highest, Level 3, NCQA recognition. Following NCQA recognition, 88.9 percent stabilized or increased their use of PCMH processes, although several specific PCMH processes had very low rates of adoption overall. ConclusionsFindings demonstrate that widespread PCMH implementation is possible in a safety-net environment when external financial incentives are aligned with the goal of practice innovation. PMID:23800148

  7. SHEETEnvironment, Health and Safety Information for the Berkeley Campus Please post or circulate

    E-print Network

    Cohen, Ronald C.

    extinguish the fire (e.g., carbon dioxide, water, foam), special fire fighting procedures, and any unusual or circulate EH&S U C B E R K E L E YU C B E R K E L E Y HH SS&& EE Office of Environment, Health & Safety working with a chemical and recommend emergency procedures for spills, fire, and first aid. Before

  8. 77 FR 10666 - Pipeline Safety: Post Accident Drug and Alcohol Testing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-23

    ... and Alcohol Testing AGENCY: Pipeline and Hazardous Materials Safety Administration (PHMSA); DOT... promptly to meet the timelines for testing required by the regulations. This was further emphasized by the... testing of all potentially involved personnel despite uncertainty about the circumstances of the...

  9. SheetEnvironment, Health and Safety Information for the Berkeley Campus Please post or circulate

    E-print Network

    Cohen, Ronald C.

    sterilization at the same temperature. Because the required times for dry heat sterilization will vary sterilization Dry heat cycle - when to use Autoclave safety considerations #12;Fact Sheet: Safe and effective. Autoclaves use water, pressure and heat to create superheated steam that kills micro- organisms and spores

  10. 2 Safety and Security, A Shared Responsibility 3 Jurisdiction, Structure, and Authority Crime

    E-print Network

    Sin, Peter

    Crime Reporting And Public Information 4 Consumer Information Standards Of Conduct 5 Policy Regarding and Fire Safety Report 9 Crimes of Violence And The Campus Conduct/Judicial Process Potential Sanctions 10 Governing Alcohol And Controlled Substances 12 Reporting Emergencies Or Crime On Campus 13 Emergency

  11. 76 FR 63988 - Pilot Project on NAFTA Trucking Provisions; Pre-Authorization Safety Audits

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-14

    ... Management System published in the Federal Register on January 17, 2008 (73 FR 3316), or you may visit http... PASA, however, the company provided information on its safety management processes that was validated... categories of information in the notices for the PASAs conducted during the 2007-2009 demonstration...

  12. 75 FR 3946 - Tennessee Valley Authority; Establishment of Atomic Safety and Licensing Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-25

    ... proceeding: Tennessee Valley Authority (Bellefonte Nuclear Plant, Units 1 and 2) This proceeding concerns a... the Commission's determination to reinstate the construction permits for Bellefonte Nuclear Plant... Matter of Tennessee Valley Authority (Bellefonte Nuclear Plant, Units 1 and 2), CLI-10-06, 71 NRC...

  13. Safety and Efficacy of Eltrombopag in Post-hematopoietic Stem Cell Transplantation (HSCT) Thrombocytopenia.

    PubMed

    Raut, Shreeniwas S; Shah, Sandip A; Sharanangat, Vijay V; Shah, Kamlesh M; Patel, Kinnari A; Anand, Asha S; Talati, Shailesh S; Panchal, Harsha P; Patel, Apurva A; Parikh, Sonia K; Shukla, Shilin N

    2015-12-01

    Twelve adult patients (median age 29.5 years) were started on Eltrombopag 25-50 mg/day for post-hematopoietic stem cell transplantation (HSCT) thrombocytopenia. All patients were having primary thrombocytopenia after HSCT. No patient had other secondary cause for thrombocytopenia. Two patients were allogenic subsets (1 acute myeloid leukemia i.e., AML and 1 aplastic anemia), and 10 were autologous transplants (3 multiple myeloma, 6 lymphoma and 1 AML). Nine patients were males, three were females. The median time of starting Eltrombopag was 21 days post-stem cell infusion (range day +17 to +60) at a median platelet count of 9,000/cmm (range 3,000-11,000/cmm). The median duration for treatment was 29 days. Median total dose of 812.5 mg was received by patients and they had a median platelet increment of 36,000/cmm. We observed that there were no adverse effects in these patients and there was a gradual increase in platelet count so that none of the patients had any complication due to thrombocytopenia. The cost of treatment was less than the cost of extended hospitalization and irradiated single donor platelet transfusion. PMID:26306064

  14. Construction and analysis of a human hepatotoxicity database suitable for QSAR modeling using post-market safety data.

    PubMed

    Zhu, Xiao; Kruhlak, Naomi L

    2014-07-01

    Drug-induced liver injury (DILI) is one of the most common drug-induced adverse events (AEs) leading to life-threatening conditions such as acute liver failure. It has also been recognized as the single most common cause of safety-related post-market withdrawals or warnings. Efforts to develop new predictive methods to assess the likelihood of a drug being a hepatotoxicant have been challenging due to the complexity and idiosyncrasy of clinical manifestations of DILI. The FDA adverse event reporting system (AERS) contains post-market data that depict the morbidity of AEs. Here, we developed a scalable approach to construct a hepatotoxicity database using post-market data for the purpose of quantitative structure-activity relationship (QSAR) modeling. A set of 2029 unique and modelable drug entities with 13,555 drug-AE combinations was extracted from the AERS database using 37 hepatotoxicity-related query preferred terms (PTs). In order to determine the optimal classification scheme to partition positive from negative drugs, a manually-curated DILI calibration set composed of 105 negatives and 177 positives was developed based on the published literature. The final classification scheme combines hepatotoxicity-related PT data with supporting information that optimize the predictive performance across the calibration set. Data for other toxicological endpoints related to liver injury such as liver enzyme abnormalities, cholestasis, and bile duct disorders, were also extracted and classified. Collectively, these datasets can be used to generate a battery of QSAR models that assess a drug's potential to cause DILI. PMID:24721472

  15. Effectiveness and safety of post-induction phase bevacizumab treatment for patients with non-small-cell lung cancer: results from the ARIES observational cohort study.

    PubMed

    Kosty, Michael P; Wozniak, Antoinette J; Jahanzeb, Mohammad; Leon, Larry; Fish, Susan; Hazard, Sebastien J; Lynch, Thomas J

    2015-12-01

    Data from randomized, controlled trials suggest that post-induction phase (IP) treatment with bevacizumab may benefit patients with advanced non-small-cell lung cancer (NSCLC). Real-world clinical practice, however, can involve variable use and patterns of treatment in broader patient populations. To assess the effect of bevacizumab on post-IP overall survival (OS) following IP chemotherapy + bevacizumab, analyses were conducted in patients enrolled in the Avastin® Registry-Investigation of Effectiveness and Safety (ARIES) observational cohort study (OCS) who received post-IP bevacizumab. ARIES was a large, prospective OCS of patients who received chemotherapy in combination with bevacizumab for the first-line treatment of NSCLC. This unplanned, post hoc analysis included patients who received chemotherapy and bevacizumab and who did not have progressive disease through the completion of IP treatment. A dichotomous analysis compared outcomes in patients who did and did not receive bevacizumab before a landmark date of day 30 post IP. A cumulative exposure analysis used a time-dependent Cox regression model to assess the effect of cumulative post-IP bevacizumab exposure on post-IP OS. In the dichotomous analysis, the duration of post-IP OS was significantly longer in patients who received post-IP bevacizumab; median post-IP OS was 15.6 vs. 11.3 months, respectively (hazard ratio [HR]?=?0.80; 95 % confidence interval 0.71-0.91; P?post-IP OS by 2.7 %, on average. In conclusion, post-IP bevacizumab exposure was associated with improved post-IP OS in patients with advanced NSCLC who were enrolled in the ARIES OCS. PMID:25559289

  16. Effectiveness and Safety of Arnica montana in Post-Surgical Setting, Pain and Inflammation.

    PubMed

    Iannitti, Tommaso; Morales-Medina, Julio César; Bellavite, Paolo; Rottigni, Valentina; Palmieri, Beniamino

    2014-09-17

    Arnica montana has been widely used as a homeopathic remedy for the treatment of several inflammatory conditions in pain management and postoperative settings. This review gives an overview of the therapeutic use of Arnica montana in the above-mentioned fields also focusing on its mechanisms of action learned from animal models and in vitro studies. Arnica montana is more effective than placebo when used for the treatment of several conditions including post-traumatic and postoperative pain, edema, and ecchymosis. However, its dosages and preparations used have produced substantial differences in the clinical outcome. Cumulative evidence suggests that Arnica montana may represent a valid alternative to non-steroidal anti-inflammatory drugs, at least when treating some specific conditions. PMID:25171757

  17. 78 FR 28897 - Tennessee Valley Authority; Establishment of Atomic Safety and Licensing Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-16

    ... proceeding: Tennessee Valley Authority (Sequoyah Nuclear Plant, Units 1 and 2) This proceeding involves an... Nuclear Plant, Units 1 and 2, which are located in Soddy-Daisy, Tennessee. The current Unit 1 and Unit 2... delegation by the Commission dated December 29, 1972, see 37 FR 28710 (1972), and the...

  18. Efficacy and safety of anidulafungin in elderly, critically ill patients with invasive Candida infections: a post hoc analysis.

    PubMed

    Dimopoulos, George; Paiva, José-Artur; Meersseman, Wouter; Pachl, Jan; Grigoras, Ioana; Sganga, Gabriele; Montravers, Philippe; Auzinger, Georg; Sá, Marcio Borges; Miller, Paul J; Mar?ek, Tomas; Kantecki, Michal; Ruhnke, Markus

    2012-12-01

    Post hoc analysis of a non-comparative, prospective, multicentre, phase IIIb study was performed to compare efficacy and safety of anidulafungin in elderly (?65 years) versus non-elderly (<65 years) Intensive Care Unit (ICU) patients with candidaemia/invasive candidiasis (C/IC). Adult ICU patients with confirmed C/IC meeting ?1 of the following criteria were enrolled: post-abdominal surgery; solid tumour; renal/hepatic insufficiency; solid organ transplantation; neutropenia; age ?65 years. Patients received anidulafungin (200 mg on Day 1, 100 mg/day thereafter) for ?10 days followed by optional azole step-down therapy for a total treatment duration of 14-56 days. The primary efficacy endpoint was global (clinical and microbiological) response at the end of all therapy (EOT). Primary efficacy analysis was performed in the modified intent-to-treat (mITT) population (n=170), excluding unknown and missing responses. In total, 80 patients (47.1%) were aged ?65 years and 90 (52.9%) were aged <65 years; the mean age difference between the two groups was 21.9 years. Global success at EOT in mITT patients was similar in elderly (68.1%) and non-elderly (70.7%) patients (P=0.719). However, global success rates were significantly lower in elderly versus non-elderly patients at 2 and 6 weeks after EOT (P=0.045 and P=0.016, respectively). Ninety-day survival was significantly lower (P=0.006) for elderly (42.8%) versus non-elderly patients (63.3%). The incidence and profile of adverse events were similar in elderly and non-elderly patients. Anidulafungin was effective and safe for treatment of C/IC in elderly ICU patients, despite higher baseline severity of illness scores. PMID:22998997

  19. Safety.

    ERIC Educational Resources Information Center

    Education in Science, 1996

    1996-01-01

    Discusses safety issues in science, including: allergic reactions to peanuts used in experiments; explosions in lead/acid batteries; and inspection of pressure vessels, such as pressure cookers or model steam engines. (MKR)

  20. PAT-1 safety analysis report addendum author responses to request for additional information.

    SciTech Connect

    Weiner, Ruth F.; Schmale, David T.; Kalan, Robert J.; Akin, Lili A.; Miller, David Russell; Knorovsky, Gerald Albert; Yoshimura, Richard Hiroyuki; Lopez, Carlos; Harding, David Cameron; Jones, Perry L.; Morrow, Charles W.

    2010-09-01

    The Plutonium Air Transportable Package, Model PAT-1, is certified under Title 10, Code of Federal Regulations Part 71 by the U.S. Nuclear Regulatory Commission (NRC) per Certificate of Compliance (CoC) USA/0361B(U)F-96 (currently Revision 9). The National Nuclear Security Administration (NNSA) submitted SAND Report SAND2009-5822 to NRC that documented the incorporation of plutonium (Pu) metal as a new payload for the PAT-1 package. NRC responded with a Request for Additional Information (RAI), identifying information needed in connection with its review of the application. The purpose of this SAND report is to provide the authors responses to each RAI. SAND Report SAND2010-6106 containing the proposed changes to the Addendum is provided separately.

  1. 29 CFR 37.63 - What are the authority and procedures for conducting post-approval compliance reviews?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...documentary or other submission that explains, validates or otherwise addresses the practices under review. (c) The Director may conduct post-approval reviews using such techniques as desk audits and on-site...

  2. Post-licensure safety surveillance for human papillomavirus-16/18-AS04-adjuvanted vaccine: more than 4?years of experience

    PubMed Central

    Angelo, Maria-Genalin; Zima, Julia; Tavares Da Silva, Fernanda; Baril, Laurence; Arellano, Felix

    2014-01-01

    Purpose To summarise post-licensure safety surveillance over more than 4?years of routine use of the human papillomavirus-16/18-AS04-adjuvanted vaccine (HPV-16/18 vaccine: Cervarix®, GlaxoSmithKline, Belgium). Methods We describe global post-licensure passive surveillance data based on routine pharmacovigilance from 18 May 2007 until 17 November 2011 and enhanced surveillance implemented during the 2-year national immunisation programme in the UK (school years 2008–2010). Results Spontaneous reports from countries worldwide showed a similar pattern for the most frequently reported adverse events after HPV-16/18 vaccination. No patterns or trends were observed for potential immune-mediated diseases after vaccination. Observed incidences of Bell's palsy and confirmed Guillain–Barré syndrome were within the expected range in the general population. Outcomes of pregnancy in women who were inadvertently exposed to HPV-16/18 vaccine during pregnancy, were in line with published reports for similar populations. Enhanced surveillance of adverse events in the UK triggered a review of cases of anaphylaxis, angioedema and syncope reports, leading to an update to the prescribing information. Conclusion Collaborative partnerships between industry and national regulatory agencies facilitated rapid notification and transfer of safety information, allowing for rapid responses in the event of a safety signal of adverse event of concern. More than 4?years of post-licensure experience may provide confidence to providers and the public about the safety profile of HPV-16/18 vaccine in routine use. The safety profile appears to be consistent with pre-licensure data reporting that HPV-16/18 vaccine has an acceptable benefit–risk profile in adolescent girls and women. PMID:24644078

  3. The safety of quetiapine: results of a post-marketing surveillance study on 1728 patients in England.

    PubMed

    Twaites, Beverley R; Wilton, Lynda V; Shakir, Saad A W

    2007-06-01

    The safety of the atypical antipsychotic quetiapine as used in general practice in England was examined by prescription-event monitoring (PEM). Patients were identified from dispensed National Health Service (NHS) prescriptions issued by general practitioners (GPs) for quetiapine between October 1997 and July 1999. The outcome data were event reports obtained by sending questionnaires ('green forms') to the prescribing doctor at Least 6 months after the first prescription for an individual patient. Green forms with clinically useful information on 1728 patients (median age 39 years (IQR 30-56); 53% female) were received. The most frequently reported event during the first month of treatment was 'drowsiness/sedation' (47; 3% cohort). This was also the most frequently reported specified adverse drug reaction (ADR) to quetiapine (7; 11% of 65 reported ADRs) and the highest reported clinical reason for stopping quetiapine (51; 6% of the 734 reported reasons for stopping). There was a low incidence of extrapyramidal disease (21 during treatment, 1% of cohort) and hyperprolactinaemia (three during treatment, 0.2%) in this study. Three cases of diabetes mellitus in this cohort were reported to be a new diagnosis. Six pregnancies were reported during treatment with quetiapine, five of which were exposed during the first trimester only. There were four Live births with no reported congenital abnormaLities. Fifty-six deaths were reported during this study (3% cohort). The most frequently reported causes of death reLated to the cardiovascular (18) and respiratory (15) systems. The results of this post-marketing surveillance study demonstrated that quetiapine is generally well-tolerated when used in general practice. PMID:17656426

  4. RADIATION ORDER AUTHORIZATION NUMBER PROCEDURE As of May 14 2008, the Office of Environment, Health & Safety (EH&S) is implementing State-mandated

    E-print Network

    , Health & Safety (EH&S) is implementing State-mandated purchasing controls for radioactive materials numbers. They are the only ones able to access the approval section of the EHS website. Any radiation are the instructions for labs to access the site where they can request order authorization: 1. Go to EHS website

  5. Reactogenicity and safety of the human rotavirus vaccine, Rotarix™ in The Philippines, Sri Lanka, and India: a post-marketing surveillance study.

    PubMed

    Bravo, Lulu; Chitraka, Amarjeet; Liu, Aixue; Choudhury, Jaydeep; Kumar, Kishore; Berezo, Lennie; Cimafranca, Leonard; Chatterjee, Pallab; Garg, Pankaj; Siriwardene, Prasanna; Bernardo, Rommel; Mehta, Shailesh; Balasubramanian, Sundaram; Karkada, Naveen; Htay Han, Htay

    2014-01-01

    Regulatory bodies in The Philippines, Sri Lanka, and India require post-marketing surveillance to provide additional safety data on Rotarix™ in real-life settings. In such studies conducted in The Philippines (November 2006 to July 2012; NCT00353366), Sri Lanka (November 2008 to August 2009; NCT00779779), and India (August 2009 to April 2010; NCT00938327), 2 doses of Rotarix™ were administered according to the local prescribing information (PI). The occurrence of at least Grade "2"/"3" solicited adverse event (AE) (fever, vomiting, or diarrhea), within 15 days in The Philippines or 8 days in Sri Lanka and India; unsolicited AEs within 31 days and serious adverse events (SAEs) throughout the study were recorded. Of the 1494, 522, and 332 infants enrolled in The Philippines, Sri Lanka, and India, 14.7% 14.9% and 12.7% infants, respectively recorded at least Grade "2"/"3" solicited AEs. The most commonly reported solicited AEs were irritability in The Philippines (32.2% post-Dose-1; 23.5% post-Dose-2) and India (23.0% post-Dose-1; 13.2% post-Dose-2), and fever (18.0% post-Dose-1; 20.2% post-Dose-2) in Sri Lanka. Unsolicited AEs were recorded in 24.5% (The Philippines), 4.8% (Sri Lanka), and 6.9% (India) of infants. Forty-one SAEs were recorded in the Philippines of which 6 (decreased oral intake with increased sleeping time and constipation; pneumonia, urinary tract infection, and intussusception) were considered by the investigators as causally related to vaccination. One vaccine-unrelated SAE occurred in a Sri Lankan infant. All SAEs resolved and the infants recovered. Two doses of Rotarix™, administered to healthy infants according to local PI, were well tolerated in The Philippines, Sri Lanka, and India. PMID:25424932

  6. Efficacy and safety of aripiprazole once-monthly in obese and nonobese patients with schizophrenia: a post hoc analysis

    PubMed Central

    De Hert, Marc; Eramo, Anna; Landsberg, Wally; Kostic, Dusan; Tsai, Lan-Feng; Baker, Ross A

    2015-01-01

    Purpose To assess the efficacy and safety of aripiprazole once-monthly 400 mg (AOM 400), an extended-release injectable suspension of aripiprazole, in obese and nonobese patients. Patients and methods This post hoc analysis of a 38-week randomized, double-blind, active-controlled, noninferiority study (NCT00706654) compared the clinical profile of AOM 400 in obese (body mass index [BMI] ?30 kg/m2) and nonobese (BMI <30 kg/m2) patients with schizophrenia for ?3 years. Patients were randomized 2:2:1 to AOM 400, oral aripiprazole 10–30 mg/d, or aripiprazole once-monthly 50 mg (AOM 50 mg) (subtherapeutic dose). Within obese and nonobese patient subgroups, treatment-group differences in Kaplan–Meier estimated relapse rates at week 26 (z-test) and in observed rates of impending relapse through week 38 (chi-square test) were analyzed. Treatment-emergent adverse events (TEAEs) (>10% in any treatment group) were summarized. Results At baseline of the randomized phase, obesity rates were similar among patients randomized to AOM 400 (n=95/265, 36%), oral aripiprazole (n=95/266, 36%), and AOM 50 mg (n=43/131, 33%). In both obese and nonobese patients, relapse rates through week 38 for patients randomized to AOM 400 (obese, 7.4%; nonobese, 8.8%) were similar to those in patients on oral aripiprazole (obese, 8.4%; nonobese, 7.6%), whereas relapse rates were significantly lower with AOM 400 versus AOM 50 mg (obese, 27.9% [P=0.0012]; nonobese, 19.3% [P=0.0153]). The most common TEAEs with AOM 400 in obese and nonobese patients were insomnia (12.6% and 11.2%), headache (12.6% and 8.2%), injection site pain (11.6% and 5.3%), akathisia (10.5% and 10.6%), upper respiratory tract infection (10.5% and 4.7%), weight increase (10.5% and 8.2%), and weight decrease (6.3% and 11.8%). Within the AOM 400 group, 7.6% of patients who were nonobese at baseline became obese, and 17.9% of obese patients became nonobese during randomized treatment. Conclusion The clinical profile of AOM 400 was similar in obese and nonobese patients. PMID:26064048

  7. Efficacy and safety of cross-linked hyaluronic acid single injection on osteoarthritis of the knee: a post-marketing Phase IV study

    PubMed Central

    Bashaireh, Khaldoon; Naser, Ziad; Hawadya, Khaled Al; Sorour, Sorour; Al-Khateeb, Rami Nabeel

    2015-01-01

    Purpose The primary objective of this study was to evaluate the efficacy, safety, and duration of action of viscosupplementation with Crespine® Gel over a 9-month period. Materials and methods The study was a post-marketing Phase IV study. A total of 109 participants with osteoarthritis of the knee (grades 1–4) in the tibio–femoral compartment were recruited in Jordan. Data were collected from each participant during the baseline visit. Each participant received Crespine® Gel injection, and follow-up visits took place at 3 months, 6 months, and 9 months post-injection. Main outcome measure(s) An assessment of participants by phone was conducted at 1 month, 2 months, 4 months, 5 months, 7 months, and 8 months post-injection. Western Ontario and McMaster Universities Arthritis Index questionnaires were completed during each visit. A 72-hour visit questionnaire was used to assess the safety of the injection. Statistical analysis included a two-sided 95% confidence interval for the difference between pain scores across visits, and the percent change from baseline was calculated. Main results The full analysis included 84 participants who gave their informed consent and finished the necessary baseline and follow-up visits needed to assess efficacy and safety. Peak improvement was noted at 5 months post-injection, when pain and physical performance scores had decreased to 2.60 and 9.90, respectively, and the stiffness score was 0.33. The peak improvement in stiffness was noted at 8 months post-injection, when the stiffness score had decreased to 0.32. Significant improvements were still apparent at 9 months post-injection, when the pain score was 3.36, the stiffness score was 0.42, and the physical performance score was 11.5. All side effects were local and transient, and included pain, swelling, and redness of the knee. Most side effects were treated. Conclusion Hyaluronan should be encouraged as an alternative or adjunct treatment to oral analgesics to reduce their required doses, and delay potential future surgical intervention. PMID:25897212

  8. Safety & Environment Unit Safety Contest

    E-print Network

    Awards Safety & Environment Unit Safety Contest & We hope that this contest will improve students & post-doctoral fellows, The Safety & Environment Unit announces a new initiative intended all research groups working in labs. The first contest started on November 15th , 2009. The three

  9. 77 FR 28566 - Notice of Request for a New Information Collection (Food Safety Education Campaign-Post-Wave...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-15

    ...eRulemaking Portal: This Web site provides the ability...comment field on this Web page or attach a file...Department of Agriculture, Food Safety and Inspection...available on the FSIS Web page. In addition, FSIS...customized access to selected food safety news and...

  10. Port of Houston Authority Proposal-PART 2 December 2, 2014 Subject: Proposal for authorization to correct navigation safety deficiencies in the Bayport Ship Channel

    E-print Network

    US Army Corps of Engineers

    to correct navigation safety deficiencies in the Bayport Ship Channel and Houston Ship Channel 1. Non of Engineers determined that the alignment of the Houston Ship Channel in the vicinity of the Bayport Ship procedures be unsuitable for use. c. The Houston Ship Channel reach, in the vicinity of Bayport, sees over 16

  11. Study on the efficacy and safety of adefovir dipivoxil treatment in post-liver transplant patients with hepatitis B virus infection and lamivudine-resistant hepatitis B virus.

    PubMed

    Bárcena, R; Del Campo, S; Moraleda, G; Casanovas, T; Prieto, M; Buti, M; Moreno, J M; Cuervas, V; Fraga, E; De la Mata, M; Otero, A; Delgado, M; Loinaz, C; Barrios, C; Dieguez, M L G; Mas, A; Sousa, J M; Herrero, J I; Muñoz, R; Avilés, J F; Gonzalez, A; Rueda, M

    2005-11-01

    Hepatitis B virus (HBV) recurrence and de novo HBV infection are frequent events in liver transplantation recipients. Treatment with lamivudine is initially efficient in both infections but the incidence of lamivudine-resistant HBV emergence increases over time. Adefovir appears to be promising in post-liver transplantation patients with recurrent HBV infection and lamivudine-resistant HBV. This study analyzed adefovir treatment in 42 post-liver transplantation patients who developed recurrent HBV or de novo HBV infection with lamivudine-resistant HBV (54.8% HCV-coinfected). Patients received 10 mg of oral adefovir once daily for a mean period of time of 21.5 months (range from 12 to 31 months). In 62.9% of patients, ALT levels decreased significantly. Serum HBV-DNA was undetectable in 64% of the cases. Twenty percent of patients lost HBeAg marker and 13.3% of them developed anti-HBe. In 9.5% of recipients, HBsAg became negative. There was no significant change in serum creatinine levels. In only one patient was worsening of the renal function detected, making dose adjustment necessary. No other side effects were reported. Our results confirm the efficacy and safety of adefovir treatment in post-liver transplantation patients with lamivudine-resistant HBV, neither were adefovir-resistant mutations identified in patients after 21 months of therapy, nor were there adverse events, especially renal toxicity. PMID:16386596

  12. Safety and efficacy of tiotropium Respimat versus HandiHaler in patients naive to treatment with inhaled anticholinergics: a post hoc analysis of the TIOSPIR trial

    PubMed Central

    Wise, Robert; Calverley, Peter MA; Dahl, Ronald; Dusser, Daniel; Metzdorf, Norbert; Müller, Achim; Fowler, Andy; Anzueto, Antonio

    2015-01-01

    Background: Patients with chronic obstructive pulmonary disease (COPD) who were naive to anticholinergics before the TIOtropium Safety and Performance In Respimat (TIOSPIR) trial may reflect patients seen in practice, in particular in primary care. In addition, investigating safety in these patients avoids the potential bias in patients who previously received anticholinergics and may be tolerant of their effects. Aims: The aim of this study was to evaluate whether patients naive to anticholinergic therapy who were treated with tiotropium Respimat 2.5 or 5??g had different safety and efficacy outcomes than patients treated with tiotropium HandiHaler 18??g. Methods: A post hoc analysis of patients who were not receiving anticholinergics before TIOSPIR (N=6,966/17,135) was conducted. Primary end points were risk of death from any cause and risk of COPD exacerbation. Secondary outcomes included severe exacerbation and major adverse cardiovascular events (MACE). Additional analysis of exacerbations was carried out in anticholinergic-naive patients with moderate (GOLD II) disease. Results: Anticholinergic-naive patients had less severe disease than the total TIOSPIR population. Discontinuations because of anticholinergic side effects were infrequent (0.9% overall). Similar to the primary study, patients in the tiotropium Respimat groups had no difference in the risk of death or risk of any or severe exacerbation than patients treated with tiotropium HandiHaler. Risk of MACE was similar across the Respimat and HandiHaler groups. Rates of exacerbations in the subgroup of patients with moderate disease were similar across the Respimat and HandiHaler groups. Conclusions: Tiotropium Respimat and HandiHaler have similar safety and efficacy profiles in patients who are naive to anticholinergic therapy. PMID:26540491

  13. 41 CFR 302-9.170 - Under what specific conditions may my agency authorize transportation of a POV to my post of duty...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...POV to my post of duty subsequent to the time of my assignment to that post? 302-9... Pov Transportation Subsequent to the Time of Assignment § 302-9.170 Under...POV to my post of duty subsequent to the time of my assignment to that post?...

  14. 41 CFR 302-9.170 - Under what specific conditions may my agency authorize transportation of a POV to my post of duty...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...POV to my post of duty subsequent to the time of my assignment to that post? 302-9... Pov Transportation Subsequent to the Time of Assignment § 302-9.170 Under...POV to my post of duty subsequent to the time of my assignment to that post?...

  15. 41 CFR 302-9.170 - Under what specific conditions may my agency authorize transportation of a POV to my post of duty...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...POV to my post of duty subsequent to the time of my assignment to that post? 302-9... Pov Transportation Subsequent to the Time of Assignment § 302-9.170 Under...POV to my post of duty subsequent to the time of my assignment to that post?...

  16. 41 CFR 302-9.170 - Under what specific conditions may my agency authorize transportation of a POV to my post of duty...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...POV to my post of duty subsequent to the time of my assignment to that post? 302-9... Pov Transportation Subsequent to the Time of Assignment § 302-9.170 Under...POV to my post of duty subsequent to the time of my assignment to that post?...

  17. 41 CFR 302-9.170 - Under what specific conditions may my agency authorize transportation of a POV to my post of duty...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...POV to my post of duty subsequent to the time of my assignment to that post? 302-9... Pov Transportation Subsequent to the Time of Assignment § 302-9.170 Under...POV to my post of duty subsequent to the time of my assignment to that post?...

  18. Efficacy and Safety of Remifemin on Peri-Menopausal Symptoms Induced by Post-Operative GnRH-a Therapy for Endometriosis: A Randomized Study versus Tibolone

    PubMed Central

    Chen, Jiming; Gao, Hongyan; Li, Qin; Cong, Jing; Wu, Jie; Pu, Dahua; Jiang, Guohua

    2014-01-01

    Background The aim of this study was to investigate clinical efficacy and safety of Remifemin on peri-menopausal symptoms in endometriosis patients with a post-operative GnRH-a therapy. Material/Methods We treated 116 women who had endometriosis with either Remifemin (n=56) 20 mg bid po or Tibolone (n=60) 2.5 mg qd po for 12 weeks after GnRH-a injection. The efficacy was evaluated by Kupperman menopausal index (KMI), and hot flash/sweating scores. The safety parameters such as liver and renal functions, lipid profile, endometrial thickness, and serum sex hormone level, as well as the incidence of adverse events were recorded. Results (1) After GnRH-a therapy, KMI and hot flash/sweating scores in both groups increased significantly (P<0.05) but we found no significant difference for KMI (2.87±1.40 for Remifemin and 2.70±1.26 for Tibolone) and hot flash/sweating scores (0.94±1.72 for Remifemin and 1.06±1.78 for Tibolone) between the 2 groups (P>0.05). (2) No statistical change was observed in liver or renal functions and lipid profile in both groups before and after the treatment (P>0.05). The post-therapeutic serum FSH, LH, and E2 level and endometrial thickness decreased remarkably in both groups (P<0.05). E2 level in the Remifemin group was obviously lower than that in the Tibolone group (P<0.05), and FSH and LH levels were strongly higher (P<0.05). No significant difference in thickness were found in either group (P>0.05). The Remifemin group had far fewer adverse events than the Tibolone group (P<0. 05). Conclusions Compared with Tibolone, Remifemin had a similar clinical efficacy and was safer for the peri-menopausal symptoms induced by GnRH-a in endometriosis patients. PMID:25321621

  19. VEHS Radiation Safety Radioactive Material Sink Disposal Log

    E-print Network

    Wikswo, John

    be disposed in a sink posted with a "Radioactive Hot Sink" label by VEHS radiation safety. Date of DisposalVEHS Radiation Safety Radioactive Material Sink Disposal Log Keep Posted ­ VEHS Radiation Safety: Date Entered: ____________ Initials: _____ Principal Investigator: _____________________ Date Posted

  20. [Safety and effectiveness of pemetrexed in patients with non-small cell lung cancer in Japan - analysis of post-marketing surveillance].

    PubMed

    Okubo, Sumiko; Kobayashi, Noriko; Taketsuna, Masanori; Kaneko, Naoya; Enatsu, Sotaro; Nishiuma, Shinichi

    2014-04-01

    The safety and effectiveness of pemetrexed(PEM)in patients with non-small cell lung cancer(NSCLC)were reviewed using data from post-marketing surveillance. Among 699 patients registered from June 2009 to May 2010, 683 patients were analyzed(343, first-line therapy: 340, second-line therapy or beyond). Patient backgrounds were as follows: median age=65 years(16.1%B75 years old); 64.7% male; 91.9% performance status 0-1; 83.2% Stage IV; 99.0% non-squamous cell cancer. Also, 86% of the first-line and 20% of the second-line cohort were receiving a concomitant anti-cancer drug(mostly platinum agents). The incidence rate of adverse drug reactions(ADR)was 76.7%, including serious cases(18.0%). The most common ADRs were decreased white blood cell count(26.8%), decreased neutrophil count(25.3%), anemia(19.2%), decreased platelet count(17.0%), and nausea(23.0%). The incidence of interstitial lung disease, which is a concern during chemotherapy, was 2.6%. Peripheral neuropathy and alopecia, events influencing a patient's quality of life, were less than 1%. The estimated median survival time was 23.2 months[95%CI: 19.8 months-not calculable]in the first-line cohort, and 11.8 months[95% CI: 10.5-13.7 months]in the B second-line cohort. The surveillance results showed no apparent difference in total ADRs in this current study compared to the safety profile established in clinical trials previously conducted in Japan and overseas. These results demonstrate the safety and effectiveness of PEM treatment for NSCLC patients in daily clinical settings. PMID:24743364

  1. 49 CFR Appendix to Subpart H of... - Explanation of Pre-Authorization Safety Audit Evaluation Criteria for Non-North America-Domiciled...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... safety audit will include: (1) Verification of available performance data and safety management programs... facilities or management systems, including verification of records of periodic vehicle inspections; (8... to review safety management controls and evaluate any written safety oversight policies and...

  2. 49 CFR Appendix A to Subpart E of... - Explanation of Pre-Authorization Safety Audit Evaluation Criteria for Mexico-Domiciled Motor...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...) Verification of available performance data and safety management programs; (2) Verification of a controlled... the carrier's safety inspection, maintenance, and repair facilities or management systems, including... review safety management controls and evaluate any written safety oversight policies and practices....

  3. 49 CFR Appendix to Subpart H of... - Explanation of Pre-Authorization Safety Audit Evaluation Criteria for Non-North America-Domiciled...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... safety audit will include: (1) Verification of available performance data and safety management programs... facilities or management systems, including verification of records of periodic vehicle inspections; (8... to review safety management controls and evaluate any written safety oversight policies and...

  4. 49 CFR Appendix to Subpart H of... - Explanation of Pre-Authorization Safety Audit Evaluation Criteria for Non-North America-Domiciled...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... safety audit will include: (1) Verification of available performance data and safety management programs... facilities or management systems, including verification of records of periodic vehicle inspections; (8... to review safety management controls and evaluate any written safety oversight policies and...

  5. 49 CFR Appendix A to Subpart E of... - Explanation of Pre-Authorization Safety Audit Evaluation Criteria for Mexico-Domiciled Motor...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...) Verification of available performance data and safety management programs; (2) Verification of a controlled... the carrier's safety inspection, maintenance, and repair facilities or management systems, including... review safety management controls and evaluate any written safety oversight policies and practices....

  6. 41 CFR 302-9.175 - When I am authorized to transport a POV, including a replacement POV, to my post of duty...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...post of duty subsequent to the time of my assignment to that post...Property Management Federal Travel Regulation System RELOCATION...Transportation Subsequent to the Time of Assignment § 302-9...post of duty subsequent to the time of my assignment to that...

  7. 41 CFR 302-9.175 - When I am authorized to transport a POV, including a replacement POV, to my post of duty...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...post of duty subsequent to the time of my assignment to that post...Property Management Federal Travel Regulation System RELOCATION...Transportation Subsequent to the Time of Assignment § 302-9...post of duty subsequent to the time of my assignment to that...

  8. 41 CFR 302-9.175 - When I am authorized to transport a POV, including a replacement POV, to my post of duty...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...post of duty subsequent to the time of my assignment to that post...Property Management Federal Travel Regulation System RELOCATION...Transportation Subsequent to the Time of Assignment § 302-9...post of duty subsequent to the time of my assignment to that...

  9. 41 CFR 302-9.175 - When I am authorized to transport a POV, including a replacement POV, to my post of duty...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...post of duty subsequent to the time of my assignment to that post...Property Management Federal Travel Regulation System RELOCATION...Transportation Subsequent to the Time of Assignment § 302-9...post of duty subsequent to the time of my assignment to that...

  10. Safety of Japanese encephalitis live attenuated vaccination in post-marketing surveillance in Guangdong, China, 2005-2012.

    PubMed

    Liu, Yu; Lin, Hualiang; Zhu, Qi; Wu, Chenggang; Zhao, Zhanjie; Zheng, Huizhen

    2014-03-26

    We reviewed the adverse events following immunization of live attenuated Japanese encephalitis vaccine in Guangdong Province, China. During the period of 2005-2012, 23 million doses of live attenuated Japanese encephalitis vaccine were used and 1426 adverse events were reported (61.24 per million doses); of which, 570 (40%) were classified as allergic reactions (24.48 per million doses), 31 (2%) were neurologic events (1.33 per million doses), and 36 (2.5%) were diagnosed as serious adverse events (1.55 per million doses). This study suggests that the JEV-L has a reasonable safety profile, most adverse events are relatively mild, with relatively rare neurologic events being observed. PMID:24503272

  11. Analysis of factors influencing the overall effect of racecadotril on childhood acute diarrhea. Results from a real-world and post-authorization surveillance study in Venezuela

    PubMed Central

    Chacón, Jose

    2010-01-01

    Drug efficacy might differ from clinical trial results when performed in clinical daily conditions. Therefore, it is mandatory to conduct trials about effectiveness to improve external validity. This post-authorization, open-label, noncontrolled, prospective, multicenter, observational, and naturalistic trial was designed to search for factors influencing the racecadotril overall effect on childhood acute watery diarrhea in a real-world setting of Venezuela. There were 3,873 children with acute watery diarrhea treated with racecadotril, an enkephalin breakdown blocker plus oral rehydration therapy by 97 pediatricians. Evaluations were carried out daily until emission of two consecutive formed stools or absence of watery bowel movements for 24 hours. The primary end-point was time-to-relief, defined as the time from first racecadotril dose to the last watery bowel movement time. Age, gender, nursing type, nursing status during diarrhea, diarrhea severity, and co-medication were considered as factors in the statistical analysis. The primary end-point was evaluated by factors using UNIANOVA, and post-hoc tests were done. A multiple regression analysis was carried out to identify factors affecting drug performance, racecadotril effectiveness and tolerability overall assessment was searched by physicians and patients, and inter-observer agreement was evaluated by kappa statistics. The mean time-to-relief was 18.5 ± 12.5 hours [95% confidence interval 17.9–19.0] and the diarrhea severity was the only variable with significant and independent weight on racecadotril effectiveness explaining 23% of time-to-relief variance, but even in severe diarrhea cases this time was less than 24 hours. High agreement about satisfactory perception on effectiveness and tolerability was reached among physicians and patients. In conclusion, the racecadotril overall effect, evaluated in a real-world setting of Venezuela, was in agreement with results of some earlier controlled trials. It was only influenced by severity of diarrhea episode, as well as being considered an effective and well tolerated treatment by physicians and patients. PMID:20668711

  12. Safety of besifloxacin ophthalmic suspension 0.6% in refractive surgery: a retrospective chart review of post-LASIK patients

    PubMed Central

    Nielsen, Steven A; McDonald, Marguerite B; Majmudar, Parag A

    2013-01-01

    Background To evaluate the safety of besifloxacin ophthalmic suspension 0.6% when used in laser-assisted in situ keratomileusis (LASIK) prophylactic antibiotic regimens. Methods Retrospective surveillance of LASIK surgery cases where besifloxacin ophthalmic suspension 0.6% or moxifloxacin ophthalmic solution 0.5% were prescribed as prophylactic medications. Surgeons from nine US surgical centers provided retrospective case information on surgical outcomes from consecutive cases and reported any adverse events related to the antibacterial used. The primary endpoint was the incidence of adverse drug reactions. Results A total of 801 case reports (801 eyes; 534 besifloxacin, 267 moxifloxacin) were obtained. The mean (standard deviation [SD]) age at time of surgery was 36.1 (10.6) years. The mean (SD) duration of antibiotic treatment was 8.6 (2.2) days in the besifloxacin group and 8.0 (2.3) in the moxifloxacin group; daily dosing frequency was higher in the moxifloxacin group preoperatively, on the day of surgery, and postoperatively. There were no reports of adverse drug reactions for the 801 eyes in this surveillance. There were no differences between the besifloxacin and moxifloxacin treatment groups in rates of unexpected corneal findings (2.1% vs 1.5%, P = 0.949). The distribution of final visual acuity for the besifloxacin and moxifloxacin groups were similar (P = 0.793). Most cases had a final visual acuity of 20/20 or better. Conclusion In this retrospective surveillance study, the prophylactic use of besifloxacin ophthalmic suspension 0.6% and moxifloxacin ophthalmic solution 0.5% in patients undergoing LASIK surgery was not associated with any adverse drug reactions. PMID:23355771

  13. Post Harvest Pocket Guide

    E-print Network

    Pittendrigh, Barry

    -Mail ________________________________________________________________________ SPACE FOR YOUR COMPANY NAME AND ADDRESS HERE POST HARVEST POCKET GUIDE S.L.A.M. Grain Drying and Aeration Insect Pest Management Rodent Pest Management Molds Sampling Grain and Grades Safety Reference

  14. A right hemisphere safety backup at work: hypotheses for deep hypnosis, post-traumatic stress disorder, and dissociation identity disorder.

    PubMed

    Burnand, Gordon

    2013-09-01

    Problem theory points to an a priori relation between six key problems of living, to which people have adapted through evolution. Children are guided through the problems one by one, learning to switch between them automatically and unawares. The first problem of raising hope of certainty (about the environment), is dealt with in the right hemisphere (RH). The second of raising hope of freedom (or power to control), is dealt with in the left hemisphere (LH). Here adventurousness and ignoring the goodness of outcomes potentially create recklessness. When uncertainty rises the RH activates a backup with an override that substitutes immobility, takes over sensory inputs, but allows obedience to parental commands, and a cut-out that stops new work on the freedom problem. Support for the use of the backup by infants is found in the immobility that precedes the crying in strange conditions, and in childhood EEGs. The hypothesis that the backup is active in deep hypnosis imposes accord on findings that appear contradictory. For example it accounts for why observations during deep hypnosis emphasize the activity of the RH, but observations of responsive people not under hypnosis emphasize the activity of the LH. The hypothesis that the backup is active in post-traumatic stress disorder (PTSD) is supported by (a) fMRI observations that could reflect the cut-out, in that part of the precuneus has low metabolism, (b) the recall of motionlessness at the time of the trauma, (c) an argument that playing dead as a defence against predators is illogical, (d) the ease of hypnosis. With dissociative identity disorder (DID), the theory is consistent with up to six alters that have executive control and one trauma identity state where childhood traumas are re-experienced. Support for the cut-out affecting the trauma identity state comes from suppression of part of the precuneus and other parts of the parietal lobe when the trauma identity state is salient and a general script about a trauma is listened to. Support also comes from the ease of hypnosis. The cut-out acts independently of the override. It is linked to low metabolism at the same point in the left precuneus by evidence from all three conditions, hypnosis, PTSD and DID. The concept of dissociation is not required with any of the hypotheses. PMID:23790686

  15. 49 CFR Appendix to Subpart H of... - Explanation of Pre-Authorization Safety Audit Evaluation Criteria for Non-North America-Domiciled...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...Criteria for Non-North America-Domiciled Motor Carriers Appendix to Subpart H of Part...Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR CARRIER SAFETY REGULATIONS SAFETY...

  16. 49 CFR Appendix to Subpart H of... - Explanation of Pre-Authorization Safety Audit Evaluation Criteria for Non-North America-Domiciled...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...Criteria for Non-North America-Domiciled Motor Carriers Appendix to Subpart H of Part...Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR CARRIER SAFETY REGULATIONS SAFETY...

  17. 49 CFR Appendix to Subpart H of... - Explanation of Pre-Authorization Safety Audit Evaluation Criteria for Non-North America-Domiciled...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...Criteria for Non-North America-Domiciled Motor Carriers Appendix to Subpart H of Part...Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR CARRIER SAFETY REGULATIONS SAFETY...

  18. 49 CFR Appendix to Subpart H of... - Explanation of Pre-Authorization Safety Audit Evaluation Criteria for Non-North America-Domiciled...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...Criteria for Non-North America-Domiciled Motor Carriers Appendix to Subpart H of Part...Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR CARRIER SAFETY REGULATIONS SAFETY...

  19. 14 CFR 417.415 - Post-launch and post-flight-attempt hazard controls.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Post-launch and post-flight-attempt hazard controls. 417.415 Section 417.415 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH SAFETY Ground Safety § 417.415 Post-launch and post-flight-attempt hazard...

  20. Immunogenicity and Safety of Four Different Dosing Regimens of Anthrax Vaccine Adsorbed for Post-Exposure Prophylaxis for Anthrax in Adults

    PubMed Central

    Bernstein, David I.; Jackson, Lisa; Patel, Shital M.; El Sahly, Hana M.; Spearman, Paul; Rouphael, Nadine; Rudge, Thomas L.; Hill, Heather; Goll, Johannes B.

    2014-01-01

    Background Strategies to implement post exposure prophylaxis (PEP) in case of an anthrax bioterror event are needed. To increase the number of doses of vaccine available we evaluated reducing the amount of vaccine administered at each of the vaccinations, and reducing the number of doses administered. Methods Healthy male and non-pregnant female subjects between the ages of 18 and 65 were enrolled and randomized 1:1:1:1 to one of four study arms to receive 0.5 mL (standard dose) of vaccine subcutaneously (SQ) at: A) days 0, 14; B) days 0 and 28; C) days 0, 14, and 28; or D) 0.25 ml at days 0, 14, and 28. A booster was provided on day 180. Safety was assessed after each dose. Blood was obtained on days 0, 7, 14, 21, 28, 35, 42, 49, 56, 63, 70, 84, 100, 180, and 201 and both Toxin Neutralizing antibody and anti-PA IgG antibody measured. Results Almost all subjects developed some local reactions with 46% to 64% reported to be of moderate severity and 3.3% severe during the primary series. Vaccine groups that included a day 14 dose induced a ?4 fold antibody rise in more subjects on days 21, 28 and 35 than the arm without a day 14 dose. However, schedules with a full day 28 dose induced higher peak levels of antibody that persisted longer. The half dose regimen did not induce antibody as well as the full dose study arms. Conclusion Depending on the extent of the outbreak, effectiveness of antibiotics and availability of vaccine, the full dose 0, 28 or 0, 14, 28 schedules may have advantages. PMID:25239484

  1. 49 CFR Appendix A to Subpart E of... - Explanation of Pre-Authorization Safety Audit Evaluation Criteria for Mexico-Domiciled Motor...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...Evaluation Criteria for Mexico-Domiciled Motor Carriers A Appendix A to Subpart...Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR CARRIER SAFETY REGULATIONS RULES...

  2. 49 CFR Appendix A to Subpart E of... - Explanation of Pre-Authorization Safety Audit Evaluation Criteria for Mexico-Domiciled Motor...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...Evaluation Criteria for Mexico-Domiciled Motor Carriers A Appendix A to Subpart...Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR CARRIER SAFETY REGULATIONS RULES...

  3. 49 CFR Appendix A to Subpart E of... - Explanation of Pre-Authorization Safety Audit Evaluation Criteria for Mexico-Domiciled Motor...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...Evaluation Criteria for Mexico-Domiciled Motor Carriers A Appendix A to Subpart...Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR CARRIER SAFETY REGULATIONS RULES...

  4. 49 CFR Appendix A to Subpart E of... - Explanation of Pre-Authorization Safety Audit Evaluation Criteria for Mexico-Domiciled Motor...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...Evaluation Criteria for Mexico-Domiciled Motor Carriers A Appendix A to Subpart...Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR CARRIER SAFETY REGULATIONS RULES...

  5. The European Food Safety Authority recommendation for polyunsaturated fatty acid composition of infant formula overrules breast milk, puts infants at risk, and should be revised.

    PubMed

    Crawford, Michael A; Wang, Yiqun; Forsyth, Stewart; Brenna, J Thomas

    2015-12-01

    The European Food Safety Authority (EFSA) has concluded from a limited review of the literature that although docosahexaenoic acid (DHA) is required for infant formula, arachidonic acid is not required "even in the presence of DHA" (EFSA Journal, 12 (2014) 3760). This flawed opinion is grounded in human trials which tested functionality of DHA in neural outcomes and included arachidonic acid ostensibly to support growth. The EFSA report mistakes a nutrient ubiquitous in the diets of newborn infants, through breast milk and with wide-ranging health and neurodevelopmental effects, for an optional drug targeted to a particular outcome that is properly excluded when no benefit is found for that particular outcome. Arachidonic acid has very different biological functions compared to DHA, for example, arachidonic acid has unique functions in the vasculature and in specific aspects of immunity. Indeed, the overwhelming majority of trials include both DHA and arachidonic acid, and test development specific to DHA such as neural and visual development. DHA suppresses membrane arachidonic acid concentrations and its function. An infant formula with DHA and no arachidonic acid runs the risk of cardio and cerebrovascular morbidity and even mortality through suppression of the favorable oxylipin derivatives of arachidonic acid. The EFSA recommendation overruling breast milk composition should be revised forthwith, otherwise being unsafe, ungrounded in most of the evidence, and risking lifelong disability. PMID:26432509

  6. September 2011 APPENDIX D: Mandatory Information Posted in the College of Pharmacy and Nutrition

    E-print Network

    Saskatchewan, University of

    September 2011 APPENDIX D: Mandatory Information Posted in the College of Pharmacy and Nutrition College WSEP information posted. Minutes of Chemistry and Pharmacy & Nutrition Local (Thorvaldson) Safety Committee posted. Minutes of Pharmacy and Nutrition Local Workplace Safety and Environmental Protection

  7. Phase II, randomized, open, controlled study of AS03-adjuvanted H5N1 pre-pandemic influenza vaccine in children aged 3 to 9 years: follow-up of safety and immunogenicity persistence at 24 months post-vaccination

    PubMed Central

    Díez-Domingo, Javier; Baldó, José-María; Planelles-Catarino, Maria Victoria; Garcés-Sánchez, María; Ubeda, Isabel; Jubert–Rosich, Angels; Marès, Josep; Garcia-Corbeira, Pilar; Moris, Philippe; Teko, Maurice; Vanden Abeele, Carline; Gillard, Paul

    2015-01-01

    Background An AS03-adjuvanted H5N1 influenza vaccine elicited broad and persistent immune responses with an acceptable safety profile up to 6 months following the first vaccination in children aged 3–9 years. Methods In this follow-up of the Phase II study, we report immunogenicity persistence and safety at 24 months post-vaccination in children aged 3–9 years. The randomized, open-label study assessed two doses of H5N1 A/Vietnam/1194/2004 influenza vaccine (1·9 ?g or 3·75 ?g hemagglutinin antigen) formulated with AS03A or AS03B (11·89 mg or 5·93 mg tocopherol, respectively). Control groups received seasonal trivalent influenza vaccine. Safety was assessed prospectively and included potential immune-mediated diseases (pIMDs). Immunogenicity was assessed by hemagglutination-inhibition assay 12 and 24 months after vaccination; cross-reactivity and cell-mediated responses were also assessed. (NCT00502593). Results The safety population included 405 children. Over 24 months, five events fulfilled the criteria for pIMDs, of which four occurred in H5N1 vaccine recipients, including uveitis (n = 1) and autoimmune hepatitis (n = 1), which were considered to be vaccine-related. Overall, safety profiles of the vaccines were clinically acceptable. Humoral immune responses at 12 and 24 months were reduced versus those observed after the second dose of vaccine, although still within the range of those observed after the first dose. Persistence of cell-mediated immunity was strong, and CD4+ T cells with a TH1 profile were observed. Conclusions Two doses of an AS03-adjuvanted H5N1 influenza vaccine in children showed low but persistent humoral immune responses and a strong persistence of cell-mediated immunity, with clinically acceptable safety profiles up to 24 months following first vaccination. PMID:25652873

  8. Safety after cardiac catheterization.

    PubMed

    Huber, Charlotte

    2009-08-01

    The Pennsylvania Patient Safety Authority's reporting system is a confidential, statewide Internet reporting system to which all Pennsylvania hospitals, outpatient-surgery facilities, and birthing centers, as well as some abortion facilities, must file information on medical errors. Safety Monitor is a column from the authority that informs nurses on issues that can affect patient safety and presents strategies they can easily integrate into practice. For more information on the authority, visit www.patientsafetyauthority.org. For the original article discussed in this column or for other articles on patient safety, click on "Patient Safety Advisories" and then "Advisory Library" in the left-hand navigation menu. PMID:19641415

  9. Hand Safety

    MedlinePLUS

    ... en gatillo See More... Hand Anatomy Hand Safety Fireworks Safety Lawnmower Safety Snowblower safety Pumpkin Carving Gardening ... en gatillo See More... Hand Anatomy Hand Safety Fireworks Safety Lawnmower Safety Snowblower safety Pumpkin Carving Gardening ...

  10. [Post-therapeutic evolution of patients presenting an immunological suspicion of trypanosomiasis without parasitological proof in support of it (author's transl)].

    PubMed

    Frezil, J L; Coulm, J; Alary, J C

    1979-01-01

    The authors have recently preconised systematic treatment of every human being who is fluorescent positive. The evolution of antibodies of 26 subjects parasitologically negative and positive only in FAT test is described here after treatment with Arsobal. Statistically the antibodies decrease progressively like antibodies of Sleeping Sickness patients of first period usually did. Therefore it is possible to conclude that immunological suspects who were treated were realy sick and rightly cured. PMID:379493

  11. 75 FR 15484 - Railroad Safety Technology Program Grant Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-29

    ... Federal Railroad Administration Railroad Safety Technology Program Grant Program AGENCY: Federal Railroad... Applications. SUMMARY: The Rail Safety Technology Program is a newly authorized program under the Rail Safety...@dot.gov ). SUPPLEMENTARY INFORMATION: Authority and Funding: The Railroad Safety Technology...

  12. Safety First!

    ERIC Educational Resources Information Center

    Longfield, Judith

    2006-01-01

    In this article, the author relates how a hands-on chemistry investigation provided her the inspiration to develop an effective safety lesson for her third grade chemistry class. She began the lesson by demonstrating the use of pH indicator paper to show that ordinary household (white) vinegar was an acid. With the students, she wondered aloud…

  13. Post-test analysis of dryout test 7B' of the W-1 Sodium Loop Safety Facility Experiment with the SABRE-2P code. [LMFBR

    SciTech Connect

    Rose, S.D.; Dearing, J.F.

    1981-01-01

    An understanding of conditions that may cause sodium boiling and boiling propagation that may lead to dryout and fuel failure is crucial in liquid-metal fast-breeder reactor safety. In this study, the SABRE-2P subchannel analysis code has been used to analyze the ultimate transient of the in-core W-1 Sodium Loop Safety Facility experiment. This code has a 3-D simple nondynamic boiling model which is able to predict the flow instability which caused dryout. In other analyses dryout has been predicted for out-of-core test bundles and so this study provides additional confirmation of the model.

  14. By authority delegated from the University President, the Vice President for Business Affairs is responsible for the safety of all University facilities. Under this authority, policies are developed to

    E-print Network

    Slatton, Clint

    . Industrial Hygiene is responsible for asbestos, indoor air quality and other industrial hygiene programs are developed to provide a safe teaching, research, service, housing and recreational environment. The Environmental Health and Safety Division was established in 1974 and given the responsibility for the management

  15. 77 FR 60481 - Design, Inspection, and Testing Criteria for Air Filtration and Adsorption Units of Post-Accident...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-03

    ...Post-Accident Engineered-Safety-Feature Atmosphere Cleanup Systems in Light-Water-Cooled...Post-accident Engineered-Safety-Feature Atmosphere Cleanup Systems in Light-Water-Cooled...engineered-safety-feature (ESF) atmosphere cleanup systems in...

  16. Safety, efficacy and prognostic analyses of sunitinib in the post-marketing surveillance study of Japanese patients with gastrointestinal stromal tumor

    PubMed Central

    Komatsu, Yoshito; Ohki, Emiko; Ueno, Naomi; Yoshida, Ai; Toyoshima, Yasuharu; Ueda, Eiji; Houzawa, Hiroyuki; Togo, Kanae; Nishida, Toshirou

    2015-01-01

    Objective This study was conducted to expand the sunitinib safety database in Japanese imatinib-resistant/-intolerant gastrointestinal stromal tumor patients. Retrospective analyses investigated common adverse events as potential prognostic markers. Methods Four hundred and seventy patients who received sunitinib between June 2008 and November 2009 were analyzed for safety, progression-free survival and overall survival; 386 for objective response rate; 88% received sunitinib on Schedule 4/2 starting at 50 mg/day. Results No unexpected safety issues occurred. Grade ? 3 adverse events occurred in 70%, most commonly thrombocytopenia (33%), neutropenia (22%) and leukopenia (15%). Objective response rate was 20% (95% confidence interval 16–24). Median progression-free survival was 22.4 weeks (95% confidence interval, 21.7–24.0). The overall survival rate at 24 weeks was 91% (95% confidence interval, 88–94). Higher relative dose intensity (?70 vs. <70%) during the first 6 weeks and better Eastern Cooperative Oncology Group performance status (0 vs. ?1) were associated with longer progression-free survival (24.0 vs. 20.1 weeks; P = 0.011; and 24.1 vs. 16.9 weeks; P < 0.001) and higher 24-week overall survival rate (94 vs. 83%; P < 0.001; and 96 vs. 83%; P < 0.001). Increased progression-free survival and overall survival rates were associated with specific adverse events. Cox proportional hazard modeling adjusted for relative dose intensity and performance status established hand–foot syndrome (hazard ratio = 0.636; 95% confidence interval, 0.456–0.888) and leukopenia (hazard ratio = 0.683; 95% confidence interval, 0.492–0.948) occurring within 12 weeks were significantly correlated with increased progression-free survival. Conclusion Sunitinib showed good efficacy and tolerable safety. Factors associated with greater efficacy were relative dose intensity, performance status and specific early adverse events. PMID:26373318

  17. 49 CFR Appendix to Subpart H of... - Explanation of Pre-Authorization Safety Audit Evaluation Criteria for Non-North America-Domiciled...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... experienced during the past 12 months. Recordable accident, as defined in 49 CFR 390.5, means an accident...; (2) Verification of a controlled substances and alcohol testing program consistent with part 40 of... responsibility; (5) Review of available data concerning the carrier's safety history, and other...

  18. TWRS safety management plan

    SciTech Connect

    Popielarczyk, R.S., Westinghouse Hanford

    1996-08-01

    The Tank Waste Remediation System (TWRS) Safety Management Program Plan for development, implementation and maintenance of the tank farm authorization basis is described. The plan includes activities and procedures for: (a) Updating the current Interim Safety Basis, (b) Development,implementation and maintenance of a Basis for Interim Operations, (c) Development, implementation and maintenance of the Final Safety Analyses Report, (d) Development and implementation of a TWRS information Management System for monitoring the authorization basis.

  19. Comparative study on the immunogenicity and safety of a purified chick embryo cell rabies vaccine (PCECV) administered according to two different simulated post exposure intramuscular regimens (Zagreb versus Essen).

    PubMed

    Mahendra, B J; Narayana, Dh Ashwath; Agarkhedkar, Sharad; Ravish, H S; Harish, B R; Agarkhedkar, Shalaka; Madhusudana, S N; Belludi, Ashwin; Ahmed, Khaleel; Jonnalagedda, Rekha; Vakil, Hoshang; Bhusal, Chiranjiwi; Arora, Ashwani Kumar

    2015-01-01

    Despite availability of effective rabies vaccines, India has the highest global mortality rate for rabies. Low socio-economic communities are most affected due to lack of awareness of the disease and poor compliance to post-exposure prophylactic regimens. Currently, the only approved intramuscular regimen for post-exposure prophylaxis (PEP) against rabies in India is the Essen regimen, which consists of 5 injections administered over 5 separate days in a period of one month. The high number of doses and clinical visits, however, are major reasons for non-compliance, and thus a shorter regimen would be beneficial. In a simulated PEP trial in healthy, adult subjects, this study evaluated whether purified chick embryo cell vaccine (PCECV), administered according to the WHO-recommended 4-dose/3 visit Zagreb vaccination regimen is of equal immunogenicity and safety as the standard Essen regimen in Indian subjects. Two hundred and 50 healthy adults were enrolled and randomized into a Zagreb or Essen group, each receiving PCECV according to their respective regimen. Blood samples were collected on Days 0, 7, 14 and 42 and analyzed using the rapid fluorescent focus inhibition test (RFFIT). By Day 14, all subjects across both groups attained rabies virus neutralizing antibody (RVNA) concentrations of ? 0.5IU/ml. The Zagreb regimen was then demonstrated to be immunologically non-inferior to the Essen regimen by Day 14, which was the primary endpoint of the study. No safety issues were noted and the occurrence of adverse events was similar in both groups (17% and 15%, respectively). NCT01365494. CTRI No.: CTRI/2011/07/001857. PMID:25692792

  20. The Efficacy and Clinical Safety of Various Analgesic Combinations for Post-Operative Pain after Third Molar Surgery: A Systematic Review and Meta-Analysis

    PubMed Central

    Au, Alvin Ho Yeung; Choi, Siu Wai; Cheung, Chi Wai; Leung, Yiu Yan

    2015-01-01

    Objectives To run a systematic review and meta-analysis of randomized clinical trials aiming to answer the clinical question “which analgesic combination and dosage is potentially the most effective and safe for acute post-operative pain control after third molar surgery?”. Materials and Methods A systematic search of computer databases and journals was performed. The search and the evaluations of articles were performed by 2 independent reviewers in 3 rounds. Randomized clinical trials related to analgesic combinations for acute post-operative pain control after lower third molar surgery that matched the selection criteria were evaluated to enter in the final review. Results Fourteen studies with 3521 subjects, with 10 groups (17 dosages) of analgesic combinations were included in the final review. The analgesic efficacy were presented by the objective pain measurements including sum of pain intensity at 6 hours (SPID6) and total pain relief at 6 hours (TOTPAR6). The SPID6 scores and TOTPAR6 scores of the reported analgesic combinations were ranged from 1.46 to 6.44 and 3.24 – 10.3, respectively. Ibuprofen 400mg with oxycodone HCL 5mg had superior efficacy (SPID6: 6.44, TOTPAR6: 9.31). Nausea was the most common adverse effect, with prevalence ranging from 0-55%. Ibuprofen 200mg with caffeine 100mg or 200mg had a reasonable analgesic effect with fewer side effects. Conclusion This systematic review and meta-analysis may help clinicians in their choices of prescribing an analgesic combination for acute post-operative pain control after lower third molar surgery. It was found in this systematic review Ibuprofen 400mg combined with oxycodone HCL 5mg has superior analgesic efficacy when compared to the other analgesic combinations included in this study. PMID:26053953

  1. Efficacy and Safety of Clindamycin Phosphate 1.2% and Tretinoin 0.025% Gel for the Treatment of Acne and Acne-induced Post-inflammatory Hyperpigmentation in Patients with Skin of Color

    PubMed Central

    Young, Cherie M.; Kindred, Chesahna; Taylor, Susan C.

    2012-01-01

    Objective: To assess the efficacy and safety of a topical gel containing clindamycin 1.2% and tretinoin 0.025% for the treatment of acne and acne-induced postinflammatory hyperpigmentation (PIH) in darker skinned patients. Design: Randomized, double-blind, placebo-controlled study. Setting: Two United States clinical sites. Participants: Thirty-three patients 12 years of age or older with skin types IV to VI, mild-to-moderate facial acne, and PIH were enrolled. Measurements: Patients applied clindamycin phosphate/tretinoin gel or a nonmedicated vehicle each evening and a sun protection factor 30 sunscreen daily. Changes in skin erythema and hyperpigmentation were measured using a chromameter and photographic images. Efficacy was assessed using the Evaluators Global Acne Severity Scale, lesion counts, Post-inflammatory Hyperpigmentation Severity Scales and Patient’s Global Assessment Scale. Safety and tolerability were assessed by adverse event reports and a Safety Assessment Scale. Results: The mean (SD) baseline inflammatory lesion count was 11.9 (11.1) in clindamycin/tretinoin-treated patients, decreasing by 5.5 (6.56) after 12 weeks while the mean baseline inflammatory lesion count was 13.6 (11.15) in placebo-treated patients, decreasing by 4.1 (11.36) (p=0.05 for change from baseline, clindamycin/tretinoin vs. placebo). Clindamycin/tretinoin-treated patients generally demonstrated superior efficacy versus placebo treatment. The clindamycin/tretinoin topical gel was well tolerated, causing little or no irritation, although one patient withdrew due to periorbital edema of moderate severity possibly related to clindamycin/tretinoin gel. Conclusion: Although limited by small sample size, the results of this pilot study suggest clindamycin phosphate 1.2% and tretinoin 0.025% topical gel is a safe and effective option for treating mild-to-moderate acne in patients with skin of color. PMID:22798973

  2. Nuclear safety

    NASA Technical Reports Server (NTRS)

    Buden, D.

    1991-01-01

    Topics dealing with nuclear safety are addressed which include the following: general safety requirements; safety design requirements; terrestrial safety; SP-100 Flight System key safety requirements; potential mission accidents and hazards; key safety features; ground operations; launch operations; flight operations; disposal; safety concerns; licensing; the nuclear engine for rocket vehicle application (NERVA) design philosophy; the NERVA flight safety program; and the NERVA safety plan.

  3. A Systematic Review of the Efficacy and Safety Experience Reported for Sorafenib in Advanced Renal Cell Carcinoma (RCC) in the Post-Approval Setting

    PubMed Central

    Fishman, Mayer N.; Tomshine, Jin; Fulp, William J.; Foreman, Pamela K.

    2015-01-01

    Background Sorafenib was FDA approved in 2005 for treatment of renal cell carcinoma (RCC) based on the results of the pivotal phase 3 clinical trial, TARGET (Treatment Approaches in Renal Cancer Global Evaluation Trial). Since that time, numerous clinical studies have been undertaken that substantially broaden our knowledge of the use of sorafenib for this indication. Methods We systematically reviewed PubMed, Web of Science, Embase, Cochrane Library, and www.clinicaltrials.gov for prospective clinical studies using single agent sorafenib in RCC and published since 2005. Primary endpoints of interest were progression-free survival (PFS) and safety. PROSPERO International prospective register of systematic reviews #CRD42014010765. Results We identified 30 studies in which 2182 patients were treated with sorafenib, including 1575 patients who participated in randomized controlled phase 3 trials. In these trials, sorafenib was administered as first-, second- or third-line treatment. Heterogeneity among trial designs and reporting of data precluded statistical comparisons among trials or with TARGET. The PFS appeared shorter in second- vs. first-line treatment, consistent with the more advanced tumor status in the second-line setting. In some trials, incidences of grade 3/4 hypertension or hand-foot skin reaction (HFSR) were more than double that seen in TARGET (4% and 6%, respectively). These variances may be attributable to increased recognition of HFSR, or potentially differences in dose adjustments, that could be consequences of increased familiarity with sorafenib usage. Several small studies enrolled exclusively Asian patients. These studies reported notably longer PFS than was observed in TARGET. However, no obvious corresponding differences in disease control rate and overall survival were seen. Conclusions Collectively, more recent experiences using sorafenib in RCC are consistent with results reported for TARGET with no marked changes of response endpoints or new safety signals observed. PMID:25830512

  4. 46 CFR Sec. 4 - Posting of bond.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...2010-10-01 2010-10-01 false Posting of bond. Sec. 4 Section 4 Shipping MARITIME ADMINISTRATION, DEPARTMENT...A-NATIONAL SHIPPING AUTHORITY BONDING OF SHIP'S PERSONNEL Sec. 4 Posting of bond. The General Agent shall...

  5. 14 CFR 417.103 - Safety organization.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Safety organization. (a...a safety organization. A launch...lines of communication and approval...authority for all public safety...lines of communication, both within...operator's organization and...

  6. This article was published in an Elsevier journal. The attached copy is furnished to the author for non-commercial research and

    E-print Network

    Bashir, Rashid

    and distribution, or selling or licensing copies, or posting to personal, institutional or third party websites form) to their personal website or institutional repository. Authors requiring further information foodborne pathogenic bacteria is central to implementing effective practice to ensure food safety

  7. 49 CFR 198.11 - Grant authority.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Grant authority. 198.11 Section 198.11... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY REGULATIONS FOR GRANTS TO AID STATE PIPELINE SAFETY PROGRAMS Grant Allocation § 198.11 Grant authority. The pipeline safety laws (49...

  8. Safety and efficacy of botox injection in alleviating post-operative pain and improving quality of life in lower extremity limb lengthening and deformity correction

    PubMed Central

    Hamdy, Reggie C; Montpetit, Kathleen; Ruck-Gibis, Joanne; Thorstad, Kelly; Raney, Ellen; Aiona, Michael; Platt, Robert; Finley, Allen; Mackenzie, William; McCarthy, James; Narayanan, Unni

    2007-01-01

    Background Distraction osteogenesis is the standard treatment for the management of lower limb length discrepancy of more than 3 cm and bone loss secondary to congenital anomalies, trauma or infection. This technique consists of an osteotomy of the bone to be lengthened, application of an external fixator, followed by gradual and controlled distraction of the bone ends. Although limb lengthening using the Ilizarov distraction osteogenesis principle yields excellent results in most cases, the technique has numerous problems and is not well tolerated by many children. The objective of the current study is to determine if Botulinum Toxin A (BTX-A), which is known to possess both analgesic and paralytic actions, can be used to alleviate post-operative pain and improve the functional outcome of children undergoing distraction osteogenesis. Methods/Design The study design consists of a multi centre, randomized, double-blinded, placebo-controlled trial. Patients between ages 5–21 years requiring limb lengthening or deformity correction using distraction will be recruited from 6 different sites (Shriners Hospital for Children in Montreal, Honolulu, Philadelphia and Portland as well as DuPont Hospital for Children in Wilmington, Delaware and Hospital for Sick Children in Toronto, Ont). Approximately 150 subjects will be recruited over 2 years and will be randomized to either receive 10 units per Kg of BTX-A or normal saline (control group) intraoperatively following the surgery. Functional outcome effects will be assessed using pain scores, medication dosages, range of motion, flexibility, strength, mobility function and quality of life of the patient. IRB approval was obtained from all sites and adverse reactions will be monitored vigorously and reported to IRB, FDA and Health Canada. Discussion BTX-A injection has been widely used world wide with no major side effects reported. However, to the best of our knowledge, this is the first time BTX-A is being used under the context of limb lengthening and deformity correction. Trial Registration NCT00412035 PMID:17903262

  9. Safety of Navigation Locks

    SciTech Connect

    Kolosov, M. A.

    2002-03-15

    The author's observations and studies of safety of navigation locks are described. A mathematical model of lock reliability and its graphical interpretation are presented. The possibility of determination of the accident risk level by processing statistical data is discussed.

  10. [Safety monitoring of cell-based medicinal products (CBMPs)].

    PubMed

    Funk, Markus B; Frech, Marion; Spranger, Robert; Keller-Stanislawski, Brigitte

    2015-11-01

    Cell-based medicinal products (CBMPs), a category of advanced-therapy medicinal products (ATMPs), are authorised for the European market by the European Commission by means of the centralized marketing authorisation. By conforming to the German Medicinal Products Act (Sec. 4b AMG), national authorisation can be granted by the Paul-Ehrlich-Institut in Germany exclusively for ATMPs not based on a routine manufacturing procedure. In both procedures, quality, efficacy, and safety are evaluated and the risk-benefit balance is assessed. For the centralised procedure, mainly controlled clinical trial data must be submitted, whereas the requirements for national procedures could be modified corresponding to the stage of development of the ATMP. After marketing authorization, the marketing authorization/license holder is obligated to report all serious adverse reactions to the competent authority and to provide periodic safety update reports. If necessary, post-authorization safety studies could be imposed. On the basis of these regulatory measures, the safety of advanced therapies can be monitored and improved. PMID:26391098

  11. Safety Evaluation Report for the Tennessee Valley Authority's Plan to Decommission its Low-Level Radioactive Waste Burial Site at Muscle Shoals, Alabama

    SciTech Connect

    Gant, K.S.; Kettelle, R.H.

    1998-11-01

    From 1966 to 1981, the Tennessee Valley Authority (TVA) operated a burial site, licensed under the former 10 CFR 20.304, for low-level radioactive waste on its Muscle Shoals, Alabama, reservation. TVA submitted a decommissioning plan for the burial site and requested approval for unrestricted use of the site. The Nuclear Regulatory Commission requested Oak Ridge National Laboratory (ORNL) to evaluate this plan to determine if the site meets the radiological requirements for unrestricted use as specified in 10 CFR 20.1402; that is, an average member of the critical group would not receive more than 25 mrem/y from residual radioactivity at the TVA Low-Level Radioactive Waste Burial Site and the radioactivity has been reduced to levels as low as reasonably achievable (ALARA).

  12. 77 FR 8288 - State's Mine Health and Safety Grants

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-14

    ... Safety and Health Administration State's Mine Health and Safety Grants AGENCY: Mine Safety and Health... United States Department of Labor, Mine Safety and Health Administration (MSHA), has posted its... formula in Section 503(h) of the Federal Mine Safety and Health Act of 1977 (30 U.S.C. 953(h)) and...

  13. 76 FR 1642 - State's Mine Health and Safety Grants

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-11

    ... Safety and Health Administration State's Mine Health and Safety Grants AGENCY: Mine Safety and Health... Safety and Health Administration (MSHA), has posted its solicitation for grant applications (SGA) for the... Safety and Health Act of 1977 (30 U.S.C. 953(h)) and MSHA's final Fiscal Year 2011...

  14. Posn Desc Title Dept Authorities

    E-print Network

    Massachusetts at Lowell, University of

    Posn Desc Title Dept Campus Security Authorities: Dir of Pub Safety Cf of Police University Police of Engineering Dir of Labs, Civ & Env Eng Civil Engineering Dean of Graduate School of Education Dean

  15. The Strategy for Safety: Preventing Crises through Safety Audits

    ERIC Educational Resources Information Center

    Schwartz, Sara Goldsmith

    2013-01-01

    In this article the author demonstrates the importance of school safety audits and describes what schools should focus on in a safety audit. Ultimately, each school should determine its own safety audit strategy based on its unique circumstances, including the type of community within which it is located, the age of the students it serves, and the…

  16. Home Safety

    MedlinePLUS

    ... All Kids Safe Safety Tips Get Involved 4 Star Charity Donate Global Road Safety Sponsors Recalls Media ... All Kids Safe Safety Tips Get Involved 4 Star Charity Donate Main Content You are here Safety ...

  17. 47 CFR 0.392 - Authority delegated.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... FEDERAL COMMUNICATIONS COMMISSION...COMMISSION ORGANIZATION Delegations...Authority Public Safety and...of the Communications Act of 1934...state of communications emergency...The Chief, Public...

  18. Post-emergence herbicides useful in calendula

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Easy and effective weed control is required by growers who are considering new industrial crops. Post-emergence herbicides typically are the products of choice by today’s growers. Unfortunately, post-emergence herbicides with proven safety margins are not known for calendula (Calendula officinalis),...

  19. 49 CFR 238.211 - Collision posts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Collision posts. 238.211 Section 238.211 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PASSENGER EQUIPMENT SAFETY STANDARDS Specific Requirements for Tier I Passenger Equipment § 238.211 Collision posts....

  20. 49 CFR 238.213 - Corner posts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Corner posts. 238.213 Section 238.213 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PASSENGER EQUIPMENT SAFETY STANDARDS Specific Requirements for Tier I Passenger Equipment § 238.213 Corner posts. (a)(1)...

  1. Liquefied natural gas (LNG) safety

    NASA Technical Reports Server (NTRS)

    Ordin, P. M.

    1977-01-01

    Bibliography, assembled from computer search of NASA Aerospace Safety Data Bank, including title of report, author, abstract, source, description of figures, key references, and key words or subject terms. Publication is indexed by key subjects and by authors. Items are relevant to design engineers and safety specialists.

  2. 49 CFR 831.3 - Authority of Directors.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Transportation Other Regulations Relating to Transportation (Continued) NATIONAL TRANSPORTATION SAFETY BOARD ACCIDENT/INCIDENT INVESTIGATION PROCEDURES § 831.3 Authority of Directors. The Directors, Office of Aviation Safety, Office of Railroad Safety, Office of Highway Safety, Office of Marine Safety, and...

  3. 23 CFR 1350.7 - Post-award requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Post-award requirements. 1350.7 Section 1350.7 Highways NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION INCENTIVE GRANT CRITERIA FOR MOTORCYCLIST SAFETY PROGRAM § 1350.7 Post-award requirements. (a) Within 30 days after notification of award but in no event later...

  4. 10 CFR 63.31 - Construction authorization.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... REPOSITORY AT YUCCA MOUNTAIN, NEVADA Licenses Construction Authorization § 63.31 Construction authorization... Mountain site if it determines: (a) Safety. (1) That there is reasonable assurance that the types...

  5. 10 CFR 63.31 - Construction authorization.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... REPOSITORY AT YUCCA MOUNTAIN, NEVADA Licenses Construction Authorization § 63.31 Construction authorization... Mountain site if it determines: (a) Safety. (1) That there is reasonable assurance that the types...

  6. 10 CFR 63.31 - Construction authorization.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... REPOSITORY AT YUCCA MOUNTAIN, NEVADA Licenses Construction Authorization § 63.31 Construction authorization... Mountain site if it determines: (a) Safety. (1) That there is reasonable assurance that the types...

  7. 10 CFR 63.31 - Construction authorization.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... REPOSITORY AT YUCCA MOUNTAIN, NEVADA Licenses Construction Authorization § 63.31 Construction authorization... Mountain site if it determines: (a) Safety. (1) That there is reasonable assurance that the types...

  8. 10 CFR 63.31 - Construction authorization.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... REPOSITORY AT YUCCA MOUNTAIN, NEVADA Licenses Construction Authorization § 63.31 Construction authorization... Mountain site if it determines: (a) Safety. (1) That there is reasonable assurance that the types...

  9. Biological post

    PubMed Central

    Kumar, B. Suresh; Kumar, Senthil; Mohan Kumar, N. S.; Karunakaran, J. V.

    2015-01-01

    Anterior tooth fracture as a result of traumatic injuries, is frequently encountered in endodontic practice. Proper reconstruction of extensively damaged teeth can be achieved through the fragment reattachment procedure known as “biological restoration.” This case report refers to the esthetics and functional recovery of extensively damaged maxillary central incisor through the preparation and adhesive cementation of “biological post” in a young patient. Biological post obtained through extracted teeth from another individual–represent a low-cost option and alternative technique for the morphofunctional recovery of extensively damaged anterior teeth. PMID:26538952

  10. Biological post.

    PubMed

    Kumar, B Suresh; Kumar, Senthil; Mohan Kumar, N S; Karunakaran, J V

    2015-08-01

    Anterior tooth fracture as a result of traumatic injuries, is frequently encountered in endodontic practice. Proper reconstruction of extensively damaged teeth can be achieved through the fragment reattachment procedure known as "biological restoration." This case report refers to the esthetics and functional recovery of extensively damaged maxillary central incisor through the preparation and adhesive cementation of "biological post" in a young patient. Biological post obtained through extracted teeth from another individual-represent a low-cost option and alternative technique for the morphofunctional recovery of extensively damaged anterior teeth. PMID:26538952

  11. Safety evaluation report related to the operation of Watts Bar Nuclear Plant, Units 1 and 2, Docket Nos. 50-390 and 50-391, Tennessee Valley Authority. Supplement number 20

    SciTech Connect

    1996-02-01

    This report supplements the Safety Evaluation Report (SER), NUREG-0847 (June 1982), Supplement No. 1 (September 1982), Supplement No. 2 (January 1984), Supplement No. 3 (January 1985), Supplement No. 4 (March 1985), Supplement No. 5 (November 1990), Supplement No. 6 (April 1991), Supplement No. 7 (September 1991), Supplement No. 8 (January 1992), Supplement No. 9 (June 1992), Supplement No. 10 (October 1992), Supplement No. 11 (April 1993), Supplement No. 12 (October 1993), Supplement No. 13 (April 1994), Supplement No. 14 (December 1994), Supplement No. 15 (June 1995), Supplement No. 16 (September 1995), Supplement No. 17 (October 1995), Supplement No. 18 (October 1995), and Supplement No. 19 (November 1995) issued by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission with respect to the application filed by the Tennessee Valley Authority, as applicant and owner, for licenses to operate the Watts Bar Nuclear Plant, Units 1 and 2 (Docket Nos. 50-390 and 50-391). The facility is located in Rhea County, Tennessee, near the Watts Bar Dam on the Tennessee River. This supplement provides recent information regarding resolution of some of the issues identified in the SER.

  12. 30 CFR 56.19094 - Posting signal code.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Posting signal code. 56.19094 Section 56.19094 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE... Signaling § 56.19094 Posting signal code. A legible signal code shall be posted prominently in the...

  13. 30 CFR 57.19094 - Posting signal code.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Posting signal code. 57.19094 Section 57.19094 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE... Signaling § 57.19094 Posting signal code. A legible signal code shall be posted prominently in the...

  14. 30 CFR 57.19094 - Posting signal code.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Posting signal code. 57.19094 Section 57.19094 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE... Signaling § 57.19094 Posting signal code. A legible signal code shall be posted prominently in the...

  15. 30 CFR 56.19094 - Posting signal code.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Posting signal code. 56.19094 Section 56.19094 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE... Signaling § 56.19094 Posting signal code. A legible signal code shall be posted prominently in the...

  16. 30 CFR 56.19094 - Posting signal code.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Posting signal code. 56.19094 Section 56.19094 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE... Signaling § 56.19094 Posting signal code. A legible signal code shall be posted prominently in the...

  17. 30 CFR 57.19094 - Posting signal code.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Posting signal code. 57.19094 Section 57.19094 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE... Signaling § 57.19094 Posting signal code. A legible signal code shall be posted prominently in the...

  18. 30 CFR 57.19094 - Posting signal code.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Posting signal code. 57.19094 Section 57.19094 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE... Signaling § 57.19094 Posting signal code. A legible signal code shall be posted prominently in the...

  19. 30 CFR 57.19094 - Posting signal code.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Posting signal code. 57.19094 Section 57.19094 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE... Signaling § 57.19094 Posting signal code. A legible signal code shall be posted prominently in the...

  20. 30 CFR 56.19094 - Posting signal code.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Posting signal code. 56.19094 Section 56.19094 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE... Signaling § 56.19094 Posting signal code. A legible signal code shall be posted prominently in the...

  1. 30 CFR 56.19094 - Posting signal code.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Posting signal code. 56.19094 Section 56.19094 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE... Signaling § 56.19094 Posting signal code. A legible signal code shall be posted prominently in the...

  2. IBBME Occupational Health and Safety Committee Workplace Audit v2015 Supervisor:____________________________________, University of Toronto office storage

    E-print Network

    IBBME Occupational Health and Safety Committee Workplace Audit v2015 Supervisor Bulletin Board is in place Copy of the Occupation Health and Safety Act posted Current list of health WHMIS trained iv) Chemical inventory available and posted by entrance B) Safety Bulletin Boards Safety

  3. ACM, (2006). This is the author's version of the work. It is posted here by permission of ACM for your personal use. Not for redistribution. The definitive version was published in Communications of the ACM, Volume 49, Issue

    E-print Network

    Dannenberg, Roger B.

    2006-01-01

    a listener to begin at any location in a composition, such as the 2nd quarter of measure 48, to link visual-line score matching will soon enable many new and useful applications. For example, digital editing and post samples under various conditions such as pitch, dynamic level, articulation, etc. Score matching can

  4. Post-translational protein modification as a tool for transcription

    E-print Network

    Spoel, Steven

    Minireview Post-translational protein modification as a tool for transcription reprogramming Author, phosphorylation, plant immunity, post- translational modification, proteasome, S-nitrosylation, transcription activator. Summary Precise modulation of transcription plays a vital role in both development

  5. 48 CFR 606.304-70 - Acquisitions by overseas posts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Acquisitions by overseas... Acquisitions by overseas posts. The Departmental Competition Advocate is the approval authority for the... through the Principal Officer at the overseas post....

  6. 48 CFR 606.304-70 - Acquisitions by overseas posts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Acquisitions by overseas... Acquisitions by overseas posts. The Departmental Competition Advocate is the approval authority for the... through the Principal Officer at the overseas post....

  7. 48 CFR 606.304-70 - Acquisitions by overseas posts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Acquisitions by overseas... Acquisitions by overseas posts. The Departmental Competition Advocate is the approval authority for the... through the Principal Officer at the overseas post....

  8. 48 CFR 606.304-70 - Acquisitions by overseas posts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Acquisitions by overseas... Acquisitions by overseas posts. The Departmental Competition Advocate is the approval authority for the... through the Principal Officer at the overseas post....

  9. 48 CFR 606.304-70 - Acquisitions by overseas posts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Acquisitions by overseas... Acquisitions by overseas posts. The Departmental Competition Advocate is the approval authority for the... through the Principal Officer at the overseas post....

  10. 77 FR 33495 - Maritime Advisory Committee for Occupational Safety and Health (MACOSH)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-06

    ... Occupational Safety and Health Administration Maritime Advisory Committee for Occupational Safety and Health (MACOSH) AGENCY: Occupational Safety and Health Administration (OSHA), Labor. ACTION: Notice of MACOSH..., Assistant Secretary of Labor for Occupational Safety and Health, authorized the preparation of......

  11. Post-Polio Syndrome

    MedlinePLUS

    ... Enhancing Diversity Find People About NINDS NINDS Post-Polio Syndrome Information Page Condensed from Post-Polio Syndrome ... Español Additional resources from MedlinePlus What is Post-Polio Syndrome? Post-polio syndrome (PPS) is a condition ...

  12. Multimedia Authoring III: Web Authoring

    E-print Network

    Dahlquist, Kam D.

    Multimedia Authoring III: Web Authoring · Many multimedia applications today have a Web manifestation, whether it is the application itself or something about the application, like a DVD info Web site · The Web can "wrap" other types of content as well: Flash, audio, video · The Web provides technologies

  13. Laser Safety in the Laboratory

    ERIC Educational Resources Information Center

    Weichel, H.; And Others

    1974-01-01

    Deals with the subject of laser hazards, laser hazards control, and laser safety practices in the laboratory. Describes four categories of hazards: radiative, electrical, explosive, and toxic, and explains the status of federal regulations that seek to define lazer hazards and control safety standards. (Author/GS)

  14. Vaccine Safety Resources for Nurses

    PubMed Central

    Shimabukuro, Tom T.; Hibbs, Beth F.; Moro, Pedro L.; Broder, Karen R.; Vellozzi, Claudia

    2015-01-01

    Overview Nurses are on the front lines of health care delivery, and many of them routinely administer immunizations. The authors describe the Centers for Disease Control and Prevention’s (CDC) vaccine safety monitoring systems, explaining how nurses can access inquiry channels and other immunization information resources. Examples of recent vaccine safety inquiries are also provided. PMID:26222474

  15. 16 CFR 1700.2 - Authority.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Authority. 1700.2 Section 1700.2 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970 REGULATIONS POISON PREVENTION PACKAGING § 1700.2 Authority. Authority under the Poison Prevention Packaging Act of 1970...

  16. 16 CFR 1700.2 - Authority.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Authority. 1700.2 Section 1700.2 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970 REGULATIONS POISON PREVENTION PACKAGING § 1700.2 Authority. Authority under the Poison Prevention Packaging Act of 1970...

  17. Vaccine Safety

    MedlinePLUS

    ... Search The CDC Cancel Submit Search The CDC Vaccine Safety Note: Javascript is disabled or is not ... on Facebook Tweet Share Compartir Back to School: Vaccines for Preteens Learn about the safety of Tdap, ...

  18. Drug Safety

    MedlinePLUS

    ... How it's manufactured Results of animal testing and clinical trials The FDA also monitors a drug's safety after approval. For you, drug safety means buying online from only legitimate pharmacies and taking your medicines correctly.

  19. Safety Handbook.

    ERIC Educational Resources Information Center

    Montgomery County Public Schools, Rockville, MD.

    Safety policies, procedures, and related information are presented in this manual to assist school personnel in a continuing program of accident prevention. Chapter 1 discusses safety education and accident prevention in general. Chapter 2 covers traffic regulations relating to school safety patrols, school bus transportation, bicycles, and…

  20. Design and development of safety evaluation system of buildings on a seismic field based on the network platform

    NASA Astrophysics Data System (ADS)

    Sun, Baitao; Zhang, Lei; Chen, Xiangzhao; Zhang, Xinghua

    2015-03-01

    This paper describes a set of on-site earthquake safety evaluation systems for buildings, which were developed based on a network platform. The system embedded into the quantitative research results which were completed in accordance with the provisions from Post-earthquake Field Works, Part 2: Safety Assessment of Buildings, GB18208.2 -2001, and was further developed into an easy-to-use software platform. The system is aimed at allowing engineering professionals, civil engineeing technicists or earthquake-affected victims on site to assess damaged buildings through a network after earthquakes. The authors studied the function structure, process design of the safety evaluation module, and hierarchical analysis algorithm module of the system in depth, and developed the general architecture design, development technology and database design of the system. Technologies such as hierarchical architecture design and Java EE were used in the system development, and MySQL5 was adopted in the database development. The result is a complete evaluation process of information collection, safety evaluation, and output of damage and safety degrees, as well as query and statistical analysis of identified buildings. The system can play a positive role in sharing expert post-earthquake experience and promoting safety evaluation of buildings on a seismic field.

  1. Safety in the Elementary Science Classroom.

    ERIC Educational Resources Information Center

    Dean, Robert A.; And Others

    This safety guide for elementary school science teachers who plan science activities or laboratories for their students, presents information in the form of a flip chart that can be posted in the classroom and referred to in an emergency. Space is provided for emergency telephone numbers. A safety checklist is given for the teacher. Topics…

  2. Survey Date: Laboratory Safety Checklist

    E-print Network

    Borenstein, Elhanan

    materials storage cabinets properly labeled, and in good condition? 40 Are chemicals stored on the floor: RP: Dept: Yes Survey CommentsQuestion# No N/A Date Corrected Administrative Plans/Materials Do floor plan as described in the lab safety manual posted? 8 Hazard Communication Has the lab's chemical

  3. 31 CFR 560.528 - Aircraft safety.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Aircraft safety. 560.528 Section 560..., Authorizations and Statements of Licensing Policy § 560.528 Aircraft safety. Specific licenses may be issued on a... the safety of civil aviation and safe operation of U.S.-origin commercial passenger aircraft....

  4. 31 CFR 560.528 - Aircraft safety.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Aircraft safety. 560.528 Section 560..., Authorizations, and Statements of Licensing Policy § 560.528 Aircraft safety. Specific licenses may be issued on... insure the safety of civil aviation and safe operation of U.S.-origin commercial passenger aircraft....

  5. 31 CFR 560.528 - Aircraft safety.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Aircraft safety. 560.528 Section 560..., Authorizations and Statements of Licensing Policy § 560.528 Aircraft safety. Specific licenses may be issued on a... the safety of civil aviation and safe operation of U.S.-origin commercial passenger aircraft....

  6. 31 CFR 560.528 - Aircraft safety.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Aircraft safety. 560.528 Section 560..., Authorizations and Statements of Licensing Policy § 560.528 Aircraft safety. Specific licenses may be issued on a... the safety of civil aviation and safe operation of U.S.-origin commercial passenger aircraft....

  7. 31 CFR 560.528 - Aircraft safety.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Aircraft safety. 560.528 Section 560..., Authorizations, and Statements of Licensing Policy § 560.528 Aircraft safety. Specific licenses may be issued on... insure the safety of civil aviation and safe operation of U.S.-origin commercial passenger aircraft....

  8. 48 CFR 23.502 - Authority.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Drug-Free Workplace 23.502 Authority. Drug-Free Workplace...

  9. 48 CFR 23.502 - Authority.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Drug-Free Workplace 23.502 Authority. Drug-Free Workplace...

  10. 48 CFR 23.502 - Authority.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Drug-Free Workplace 23.502 Authority. 41 U.S.C....

  11. 48 CFR 23.502 - Authority.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Drug-Free Workplace 23.502 Authority. Drug-Free Workplace Act of 1988 (Pub. L. 100-690)....

  12. 48 CFR 23.502 - Authority.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Drug-Free Workplace 23.502 Authority. 41 U.S.C. chapter 81, Drug-Free Workplace....

  13. 48 CFR 23.502 - Authority.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Drug-Free Workplace 23.502 Authority. Drug-Free Workplace Act of 1988 (Pub. L. 100-690)....

  14. 48 CFR 23.402 - Authorities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Use of Recovered Materials and Biobased Products 23.402 Authorities. (a) The Resource Conservation and Recovery Act of 1976 (RCRA), 42 U.S.C....

  15. 48 CFR 23.201 - Authorities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...REGULATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE...WORKPLACE Energy and Water Efficiency and Renewable Energy 23.201 Authorities. (a)...

  16. 48 CFR 23.201 - Authorities.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...REGULATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE...WORKPLACE Energy and Water Efficiency and Renewable Energy 23.201 Authorities. (a)...

  17. 48 CFR 23.201 - Authorities.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...REGULATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE...WORKPLACE Energy and Water Efficiency and Renewable Energy 23.201 Authorities. (a)...

  18. 48 CFR 23.201 - Authorities.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...REGULATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE...WORKPLACE Energy and Water Efficiency and Renewable Energy 23.201 Authorities. (a)...

  19. 10 CFR 63.31 - Construction authorization.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA Licenses Construction Authorization § 63.31...construction of a geologic repository operations area at the Yucca Mountain site if it determines: (a) Safety. (1)...

  20. 10 CFR 63.31 - Construction authorization.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA Licenses Construction Authorization § 63.31...construction of a geologic repository operations area at the Yucca Mountain site if it determines: (a) Safety. (1)...

  1. 10 CFR 63.31 - Construction authorization.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA Licenses Construction Authorization § 63.31...construction of a geologic repository operations area at the Yucca Mountain site if it determines: (a) Safety. (1)...

  2. 10 CFR 63.31 - Construction authorization.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA Licenses Construction Authorization § 63.31...construction of a geologic repository operations area at the Yucca Mountain site if it determines: (a) Safety. (1)...

  3. 10 CFR 63.31 - Construction authorization.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA Licenses Construction Authorization § 63.31...construction of a geologic repository operations area at the Yucca Mountain site if it determines: (a) Safety. (1)...

  4. 48 CFR 23.801 - Authorities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., Protection of Stratospheric Ozone (40 CFR part 82). ... PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Ozone-Depleting Substances 23.801 Authorities. (a) Title VI of the Clean Air...

  5. 48 CFR 23.801 - Authorities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...) regulations, Protection of Stratospheric Ozone (40 CFR Part 82). ... PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Ozone-Depleting Substances 23.801 Authorities. (a) Title VI of the Clean Air...

  6. 77 FR 50637 - Schedule of Fees Authorized

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-22

    ...Notice 2] RIN 2127-AL09 Schedule of Fees Authorized AGENCY: National Highway Traffic...SUMMARY: This document adopts fees for Fiscal Year 2013 and until further...vehicle safety standards (FMVSS). These fees are needed to maintain the registered...

  7. 47 CFR 97.111 - Authorized transmissions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... SAFETY AND SPECIAL RADIO SERVICES AMATEUR RADIO SERVICE Station Operation Standards... Authorized transmissions. (a) An amateur station may transmit the following types...exchange messages with other stations in the amateur service, except those in any...

  8. 47 CFR 97.111 - Authorized transmissions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... SAFETY AND SPECIAL RADIO SERVICES AMATEUR RADIO SERVICE Station Operation Standards... Authorized transmissions. (a) An amateur station may transmit the following types...exchange messages with other stations in the amateur service, except those in any...

  9. 47 CFR 97.111 - Authorized transmissions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... SAFETY AND SPECIAL RADIO SERVICES AMATEUR RADIO SERVICE Station Operation Standards... Authorized transmissions. (a) An amateur station may transmit the following types...exchange messages with other stations in the amateur service, except those in any...

  10. 47 CFR 97.111 - Authorized transmissions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... SAFETY AND SPECIAL RADIO SERVICES AMATEUR RADIO SERVICE Station Operation Standards... Authorized transmissions. (a) An amateur station may transmit the following types...exchange messages with other stations in the amateur service, except those in any...

  11. 47 CFR 97.111 - Authorized transmissions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... SAFETY AND SPECIAL RADIO SERVICES AMATEUR RADIO SERVICE Station Operation Standards... Authorized transmissions. (a) An amateur station may transmit the following types...exchange messages with other stations in the amateur service, except those in any...

  12. 48 CFR 23.502 - Authority.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Drug-Free Workplace 23.502 Authority. Drug-Free Workplace...

  13. 48 CFR 23.502 - Authority.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Drug-Free Workplace 23.502 Authority. Drug-Free Workplace...

  14. 48 CFR 23.801 - Authorities.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...) regulations, Protection of Stratospheric Ozone (40 CFR Part 82). ... PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Ozone-Depleting Substances 23.801 Authorities. (a) Title VI of the Clean Air...

  15. 48 CFR 23.801 - Authorities.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...) regulations, Protection of Stratospheric Ozone (40 CFR Part 82). ... PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Ozone-Depleting Substances 23.801 Authorities. (a) Title VI of the Clean Air...

  16. 48 CFR 23.801 - Authorities.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...) regulations, Protection of Stratospheric Ozone (40 CFR Part 82). ... PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Ozone-Depleting Substances 23.801 Authorities. (a) Title VI of the Clean Air...

  17. 9 CFR 592.10 - Authority.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Authority. 592.10 Section 592.10 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS... this part. The Food Safety Inspection Service and its officers and employees shall not be liable...

  18. 9 CFR 592.10 - Authority.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Authority. 592.10 Section 592.10 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS... this part. The Food Safety Inspection Service and its officers and employees shall not be liable...

  19. 9 CFR 592.10 - Authority.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Authority. 592.10 Section 592.10 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS... this part. The Food Safety Inspection Service and its officers and employees shall not be liable...

  20. 9 CFR 592.10 - Authority.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Authority. 592.10 Section 592.10 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS... this part. The Food Safety Inspection Service and its officers and employees shall not be liable...

  1. 200 Area Deactivation Project Facilities Authorization Envelope Document

    SciTech Connect

    DODD, E.N.

    2000-03-28

    Project facilities as required by HNF-PRO-2701, Authorization Envelope and Authorization Agreement. The Authorization Agreements (AA's) do not identify the specific set of environmental safety and health requirements that are applicable to the facility. Therefore, the facility Authorization Envelopes are defined here to identify the applicable requirements. This document identifies the authorization envelopes for the 200 Area Deactivation.

  2. Visiting Author

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Author of Rocket Boys Homer Hickam, Jr. (left) and Marshall Space Flight Center Director Art Stephenson during a conference at Morris Auditorium. Homer Hickam worked at MSFC during the Apollo project years. As a young man, Mr. Hickam always dreamed of becoming a rocket scientist and following in the footsteps fo Wernher von Braun. Years later he would see his dream realized and had written Rocket Boys commemorating his life and the people at MSFC.

  3. Premarket Safety and Efficacy Studies for ADHD Medications in Children

    PubMed Central

    Bourgeois, Florence T.; Kim, Jeong Min; Mandl, Kenneth D.

    2014-01-01

    Background Attention-deficit hyperactivity disorder (ADHD) is a chronic condition and pharmacotherapy is the mainstay of treatment, with a variety of ADHD medications available to patients. However, it is unclear to what extent the long-term safety and efficacy of ADHD drugs have been evaluated prior to their market authorization. We aimed to quantify the number of participants studied and their length of exposure in ADHD drug trials prior to marketing. Methods We identified all ADHD medications approved by the Food and Drug Administration (FDA) and extracted data on clinical trials performed by the sponsor and used by the FDA to evaluate the drug’s clinical efficacy and safety. For each ADHD medication, we measured the total number of participants studied and the length of participant exposure and identified any FDA requests for post-marketing trials. Results A total of 32 clinical trials were conducted for the approval of 20 ADHD drugs. The median number of participants studied per drug was 75 (IQR 0, 419). Eleven drugs (55%) were approved after <100 participants were studied and 14 (70%) after <300 participants. The median trial length prior to approval was 4 weeks (IQR 2, 9), with 5 (38%) drugs approved after participants were studied <4 weeks and 10 (77%) after <6 months. Six drugs were approved with requests for specific additional post-marketing trials, of which 2 were performed. Conclusions Clinical trials conducted for the approval of many ADHD drugs have not been designed to assess rare adverse events or long-term safety and efficacy. While post-marketing studies can fill in some of the gaps, better assurance is needed that the proper trials are conducted either before or after a new medication is approved. PMID:25007171

  4. What about ex post facto

    SciTech Connect

    McKee, H.C.

    1992-07-01

    This note presents a legal question in an attempt to find an answer. The author hopes that some legal scholar can explain the principle of ex post facto in the US Constitution as it applies to some of the environmental laws. One of the major advantages of the Association is that it provides a forum for communication among members with different backgrounds and experience. An ex post facto law is one that is applied retroactively. Under such a law, a person could be punished for some act that violated a law passed after the act was committed, even though the act was legal when committed. The US Constitution prohibits such laws, as will be discussed later. States are also prohibited from enacting ex post facto laws.

  5. 49 CFR 655.44 - Post-accident testing.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Safety Administration rule 49 CFR 389.303(a)(1) or (b)(1). (ii) The employer shall also drug and alcohol... 49 Transportation 7 2010-10-01 2010-10-01 false Post-accident testing. 655.44 Section 655.44... of Testing § 655.44 Post-accident testing. (a) Accidents. (1) Fatal accidents. (i) As soon...

  6. 46 CFR 71.75-15 - Posting of Convention certificates.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 3 2013-10-01 2013-10-01 false Posting of Convention certificates. 71.75-15 Section 71.75-15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PASSENGER VESSELS INSPECTION AND CERTIFICATION Certificates Under the International Convention for Safety of Life at Sea, 1974 § 71.75-15 Posting of Convention certificates....

  7. Skateboard Safety.

    ERIC Educational Resources Information Center

    Della-Giustina, Daniel

    1979-01-01

    The growing number of skateboard injuries clearly indicates a need for both recreational facilities designed exclusively for skateboarders, and for accident- prevention-oriented safety education programs. (LH)

  8. 31 CFR 586.515 - Payments for services rendered by the Government of the FRY (S&M) to aircraft authorized...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...to aircraft authorized; aircraft and maritime safety. 586.515 Section 586...to aircraft authorized; aircraft and maritime safety. (a) Payments to the...to ensure the safety of ocean-going maritime traffic in international...

  9. 33 CFR Appendix A to Part 173 - Issuing Authorities and Reporting Authorities

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Authorities A Appendix A to Part 173 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) BOATING SAFETY VESSEL NUMBERING AND CASUALTY AND ACCIDENT REPORTING Pt. 173, App. A Appendix A to Part 173—Issuing Authorities and Reporting Authorities (a) The State is the issuing...

  10. Tasseography: Reading Post-Racial Resistance to Teaching

    ERIC Educational Resources Information Center

    Houston, Akil

    2011-01-01

    This article focuses on developing a progressive philosophy of praxis that challenges, what the author argues is, a post-racial resistance to teaching about racial injustice. Post-racial resistance to teaching can lead to forms of enlightened racism and sexism in the classroom. In this essay, the author develops and extends the use of the metaphor…

  11. 10 CFR 76.81 - Authorized use of radioactive material.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...radioactive material. 76.81 Section 76.81 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS Safety § 76.81 Authorized use of radioactive material. Unless otherwise authorized by law, the...

  12. 10 CFR 76.81 - Authorized use of radioactive material.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...radioactive material. 76.81 Section 76.81 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS Safety § 76.81 Authorized use of radioactive material. Unless otherwise authorized by law, the...

  13. 10 CFR 76.81 - Authorized use of radioactive material.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...radioactive material. 76.81 Section 76.81 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS Safety § 76.81 Authorized use of radioactive material. Unless otherwise authorized by law, the...

  14. 10 CFR 76.81 - Authorized use of radioactive material.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...radioactive material. 76.81 Section 76.81 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS Safety § 76.81 Authorized use of radioactive material. Unless otherwise authorized by law, the...

  15. 78 FR 20619 - First Responder Network Authority Board Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-05

    ...Information Administration First Responder Network Authority Board Meeting AGENCY: National...meeting of the Board of the First Responder Network Authority (FirstNet). DATES: The meeting...the nationwide public safety broadband network. For information on the...

  16. 10 CFR 76.81 - Authorized use of radioactive material.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...radioactive material. 76.81 Section 76.81 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS Safety § 76.81 Authorized use of radioactive material. Unless otherwise authorized by law, the...

  17. 47 CFR 97.107 - Reciprocal operating authority.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... SAFETY AND SPECIAL RADIO SERVICES AMATEUR RADIO SERVICE Station Operation Standards...United States (“alien”) holding an amateur service authorization granted by the...authorized to be the control operator of an amateur station located at places where...

  18. 47 CFR 97.107 - Reciprocal operating authority.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... SAFETY AND SPECIAL RADIO SERVICES AMATEUR RADIO SERVICE Station Operation Standards...United States (“alien”) holding an amateur service authorization granted by the...authorized to be the control operator of an amateur station located at places where...

  19. 47 CFR 97.107 - Reciprocal operating authority.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... SAFETY AND SPECIAL RADIO SERVICES AMATEUR RADIO SERVICE Station Operation Standards...United States (“alien”) holding an amateur service authorization granted by the...authorized to be the control operator of an amateur station located at places where...

  20. 47 CFR 97.107 - Reciprocal operating authority.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... SAFETY AND SPECIAL RADIO SERVICES AMATEUR RADIO SERVICE Station Operation Standards...United States (“alien”) holding an amateur service authorization granted by the...authorized to be the control operator of an amateur station located at places where...

  1. 47 CFR 97.107 - Reciprocal operating authority.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... SAFETY AND SPECIAL RADIO SERVICES AMATEUR RADIO SERVICE Station Operation Standards...United States (“alien”) holding an amateur service authorization granted by the...authorized to be the control operator of an amateur station located at places where...

  2. 42 CFR 3.514 - Authority to settle.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 2010-10-01 false Authority to settle. 3.514 Section 3.514 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT...PATIENT SAFETY WORK PRODUCT Enforcement Program § 3.514 Authority to settle. The Secretary has...

  3. Safety Systems

    ERIC Educational Resources Information Center

    Halligan, Tom

    2009-01-01

    Colleges across the country are rising to the task by implementing safety programs, response strategies, and technologies intended to create a secure environment for teachers and students. Whether it is preparing and responding to a natural disaster, health emergency, or act of violence, more schools are making campus safety a top priority. At…

  4. Safety First

    ERIC Educational Resources Information Center

    Taft, Darryl

    2011-01-01

    Ned Miller does not take security lightly. As director of campus safety and emergency management at the Des Moines Area Community College (DMACC), any threat requires serious consideration. As community college administrators adopt a more proactive approach to campus safety, many institutions are experimenting with emerging technologies, including…

  5. Heating Safety

    MedlinePLUS

    Heating Safety Heating equipment is a leading cause of home fire deaths. Almost half of home heating equipment fires are reported during the months of ... and February. Some simple steps can prevent most heating-related fires from happening. Safety Tips • Keep anything ...

  6. 47 CFR 90.20 - Public Safety Pool.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Public Safety Pool. 90.20 Section 90.20 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES PRIVATE LAND MOBILE RADIO SERVICES Public Safety Radio Pool § 90.20 Public Safety Pool. (a) Eligibility. The following are eligible to hold authorizations...

  7. 47 CFR 90.20 - Public Safety Pool.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 5 2012-10-01 2012-10-01 false Public Safety Pool. 90.20 Section 90.20 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES PRIVATE LAND MOBILE RADIO SERVICES Public Safety Radio Pool § 90.20 Public Safety Pool. (a) Eligibility. The following are eligible to hold authorizations...

  8. Nuclear Power - Post Fukushima

    NASA Astrophysics Data System (ADS)

    Reyes, Jose, Jr.

    2011-10-01

    The extreme events that led to the prolonged power outage at the Fukushima Daiicchi nuclear plant have highlighted the importance of assuring a means for stable long term cooling of the nuclear fuel and containment following a complete station blackout. Legislative bodies, regulatory agencies and industry are drawing lessons from those events and considering what changes, if any, are needed to nuclear power, post Fukushima. The enhanced safety of a new class of reactor designed by NuScale Power is drawing significant attention in light of the Fukushima events. During normal operation, each NuScale containment is fully immersed in a water-filled stainless steel lined concrete pool that resides underground. The pool, housed in a Seismic Category I building, is large enough to provided 30 days of core and containment cooling without adding water. After 30 days, the decay heat generations coupled with thermal radiation heat transfer is completely adequate to remove core decay heat for an unlimited period of time. These passive power systems can perform their function without requiring an external supply of water of power. An assessment of the NuScale passive systems is being performed through a comprehensive test program that includes the NuScale integral system test facility at Oregon State University

  9. Surgery for post-vitrectomy cataract

    PubMed Central

    Do, Diana V; Gichuhi, Stephen; Vedula, Satyanarayana S; Hawkins, Barbara S

    2014-01-01

    Background Cataract formation or acceleration can occur after intraocular surgery, especially following vitrectomy, a surgical technique for removing the vitreous which is used in the treatment of disorders that affect the posterior segment of the eye. The underlying problem that led to vitrectomy may limit the benefit from cataract surgery. Objectives The objective of this review was to evaluate the effectiveness and safety of surgery for post-vitrectomy cataract with respect to visual acuity, quality of life, and other outcomes. Search methods We searched CENTRAL (which contains the Cochrane Eyes and Vision Group Trials Register) (The Cochrane Library 2013, Issue 4), Ovid MEDLINE, Ovid MEDLINE in-Process and Other Non-Indexed Citations, Ovid MEDLINE Daily Update, Ovid OLDMED-LINE (January 1946 to May 2013), EMBASE (January 1980 to May 2013, Latin American and Caribbean Health Sciences Literature Database (LILACS) (January 1982 to May 2013), PubMed (January 1946 to May 2013), the metaRegister of Controlled Trials (mRCT) (www.controlled-trials.com), ClinicalTrials.gov (www.clinicaltrial.gov) and the WHO International Clinical Trials Registry Platform (ICTRP) (www.who.int/ictrp/search/en). We did not use any date or language restrictions in the electronic searches for trials. We last searched the electronic databases on 22 May 2013. Selection criteria We planned to include randomized and quasi-randomized controlled trials comparing cataract surgery with no surgery in adult patients who developed cataract following vitrectomy. Data collection and analysis Two authors screened the search results independently according to the standard methodological procedures expected by The Cochrane Collaboration. Main results We found no randomized or quasi-randomized controlled trials comparing cataract surgery with no cataract surgery for patients who developed cataracts following vitrectomy surgery. Authors' conclusions There is no evidence from randomized or quasi-randomized controlled trials on which to base clinical recommendations for surgery for post-vitrectomy cataract. There is a clear need for randomized controlled trials to address this evidence gap. Such trials should stratify participants by their age, the retinal disorder leading to vitrectomy, and the status of the underlying disease process in the contralateral eye. Outcomes assessed in such trials may include gain of vision on the Early Treatment Diabetic Retinopathy Study (ETDRS) scale, quality of life, and adverse events such as posterior capsular rupture. Both short-term (six-month) and long-term (one-year or two-year) outcomes should be examined. PMID:24357418

  10. Firearms safety program

    USGS Publications Warehouse

    U.S. Geological Survey

    2005-01-01

    The USGS provides appropriate firearms safety training for any employee or USGS volunteer who uses, handles, carries, or stores a firearm as part of his or her official duties. An employee or volunteer can be authorized to carry a firearm while on official duty once he or she has completed specified training requirements and a certificate of need and qualification inquiry. Knowledge of details for firearms storage, security, and transport is also necessary.

  11. Occupational Health & Safety Directorate QM_OHSD_GA001_Health and Safety Policy and Framework_V.1

    E-print Network

    Chittka, Lars

    Occupational Health & Safety Directorate QM_OHSD_GA001_Health and Safety Policy and Framework_V.1 Status: Live ­ February 2012 Author: Darren Ford Occupational Health, Safety and Well-being Policy......................................................................................................................19 2.10 Framework for the successful management of occupational health, safety and well

  12. 9 CFR 592.10 - Authority.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Authority. 592.10 Section 592.10 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS INSPECTION VOLUNTARY INSPECTION OF EGG PRODUCTS Administration § 592.10 Authority. The Administrator shall perform, for and under the supervision of...

  13. 47 CFR 97.111 - Authorized transmissions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Authorized transmissions. 97.111 Section 97.111 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES AMATEUR RADIO SERVICE Station Operation Standards § 97.111 Authorized transmissions. (a) An amateur station may transmit the following types of...

  14. 48 CFR 50.202 - Authorities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...Support Anti-terrorism by Fostering Effective Technologies Act of 2002 50.202 Authorities. The following authorities apply...Support Anti-terrorism by Fostering Effective Technologies Act of 2002 (SAFETY Act), 6 U.S.C. 441-444. (b)...

  15. 48 CFR 50.202 - Authorities.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...Support Anti-terrorism by Fostering Effective Technologies Act of 2002 50.202 Authorities. The following authorities apply...Support Anti-terrorism by Fostering Effective Technologies Act of 2002 (SAFETY Act), 6 U.S.C. 441-444. (b)...

  16. 48 CFR 50.202 - Authorities.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...Support Anti-terrorism by Fostering Effective Technologies Act of 2002 50.202 Authorities. The following authorities apply...Support Anti-terrorism by Fostering Effective Technologies Act of 2002 (SAFETY Act), 6 U.S.C. 441-444. (b)...

  17. 48 CFR 50.202 - Authorities.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...Support Anti-terrorism by Fostering Effective Technologies Act of 2002 50.202 Authorities. The following authorities apply...Support Anti-terrorism by Fostering Effective Technologies Act of 2002 (SAFETY Act), 6 U.S.C. 441-444. (b)...

  18. 48 CFR 50.202 - Authorities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...Support Anti-terrorism by Fostering Effective Technologies Act of 2002 50.202 Authorities. The following authorities apply...Support Anti-terrorism by Fostering Effective Technologies Act of 2002 (SAFETY Act), 6 U.S.C. 441-444. (b)...

  19. 30 CFR 282.11 - Director's authority.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 2 2012-07-01 2012-07-01 false Director's authority. 282.11 Section 282.11 Mineral Resources BUREAU OF SAFETY AND ENVIRONMENTAL ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE... Responsibilities of Director § 282.11 Director's authority. (a)-(c) (d)(1) The Director may approve...

  20. 30 CFR 282.11 - Director's authority.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 2 2013-07-01 2013-07-01 false Director's authority. 282.11 Section 282.11 Mineral Resources BUREAU OF SAFETY AND ENVIRONMENTAL ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE... Responsibilities of Director § 282.11 Director's authority. (a)-(c) (d)(1) The Director may approve...

  1. 47 CFR 97.111 - Authorized transmissions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 5 2012-10-01 2012-10-01 false Authorized transmissions. 97.111 Section 97.111 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES AMATEUR RADIO SERVICE Station Operation Standards § 97.111 Authorized transmissions. (a) An amateur station may transmit the following types of...

  2. 75 FR 3471 - International Conference on Harmonisation; Guidance on M3(R2) Nonclinical Safety Studies for the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-21

    ...Safety Studies for the Conduct of Human Clinical Trials and Marketing Authorization for...Safety Studies for the Conduct of Human Clinical Trials and Marketing Authorization for...their relation to the conduct of human clinical trials and marketing authorization...

  3. French policy for managing the post-accident phase of a nuclear accident.

    PubMed

    Gallay, F; Godet, J L; Niel, J C

    2015-06-01

    In 2005, at the request of the French Government, the Nuclear Safety Authority (ASN) established a Steering Committee for the Management of the Post-Accident Phase of a Nuclear Accident or a Radiological Emergency, with the objective of establishing a policy framework. Under the supervision of ASN, this Committee, involving several tens of experts from different backgrounds (e.g. relevant ministerial offices, expert agencies, local information commissions around nuclear installations, non-governmental organisations, elected officials, licensees, and international experts), developed a number of recommendations over a 7-year period. First published in November 2012, these recommendations cover the immediate post-emergency situation, and the transition and longer-term periods of the post-accident phase in the case of medium-scale nuclear accidents causing short-term radioactive release (less than 24?h) that might occur at French nuclear facilities. They also apply to actions to be undertaken in the event of accidents during the transportation of radioactive materials. These recommendations are an important first step in preparation for the management of a post-accident situation in France in the case of a nuclear accident. PMID:25915552

  4. Software safety

    NASA Technical Reports Server (NTRS)

    Leveson, Nancy

    1987-01-01

    Software safety and its relationship to other qualities are discussed. It is shown that standard reliability and fault tolerance techniques will not solve the safety problem for the present. A new attitude requires: looking at what you do NOT want software to do along with what you want it to do; and assuming things will go wrong. New procedures and changes to entire software development process are necessary: special software safety analysis techniques are needed; and design techniques, especially eliminating complexity, can be very helpful.

  5. Hanford Generic Interim Safety Basis

    SciTech Connect

    Lavender, J.C.

    1994-09-09

    The purpose of this document is to identify WHC programs and requirements that are an integral part of the authorization basis for nuclear facilities that are generic to all WHC-managed facilities. The purpose of these programs is to implement the DOE Orders, as WHC becomes contractually obligated to implement them. The Hanford Generic ISB focuses on the institutional controls and safety requirements identified in DOE Order 5480.23, Nuclear Safety Analysis Reports.

  6. 29 CFR 1903.3 - Authority for inspection.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 5 2012-07-01 2012-07-01 false Authority for inspection. 1903.3 Section 1903.3 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR INSPECTIONS, CITATIONS AND PROPOSED PENALTIES § 1903.3 Authority for inspection. (a) Compliance Safety...

  7. 29 CFR 1903.3 - Authority for inspection.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 5 2010-07-01 2010-07-01 false Authority for inspection. 1903.3 Section 1903.3 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR INSPECTIONS, CITATIONS AND PROPOSED PENALTIES § 1903.3 Authority for inspection. (a) Compliance Safety...

  8. 29 CFR 1903.3 - Authority for inspection.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 5 2011-07-01 2011-07-01 false Authority for inspection. 1903.3 Section 1903.3 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR INSPECTIONS, CITATIONS AND PROPOSED PENALTIES § 1903.3 Authority for inspection. (a) Compliance Safety...

  9. 29 CFR 1903.3 - Authority for inspection.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 5 2013-07-01 2013-07-01 false Authority for inspection. 1903.3 Section 1903.3 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR INSPECTIONS, CITATIONS AND PROPOSED PENALTIES § 1903.3 Authority for inspection. (a) Compliance Safety...

  10. 29 CFR 1903.3 - Authority for inspection.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 5 2014-07-01 2014-07-01 false Authority for inspection. 1903.3 Section 1903.3 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR INSPECTIONS, CITATIONS AND PROPOSED PENALTIES § 1903.3 Authority for inspection. (a) Compliance Safety...

  11. 29 CFR 1975.2 - Basis of authority.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Basis of authority. 1975.2 Section 1975.2 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) COVERAGE OF EMPLOYERS UNDER THE WILLIAMS-STEIGER OCCUPATIONAL SAFETY AND HEALTH ACT OF 1970 § 1975.2 Basis of authority. The power...

  12. Nuclear Safety Information Center, Its Products and Services

    ERIC Educational Resources Information Center

    Buchanan, J. R.

    1970-01-01

    The Nuclear Safety Information Center (NSIC) serves as a focal point for the collection, analysis and dissemination of information related to safety problems encountered in the design, analysis, and operation of nuclear facilities. (Author/AB)

  13. Worker Health and Safety: An Area of Conflicts

    ERIC Educational Resources Information Center

    Ashford, Nicholas A.

    1975-01-01

    The article outlines four basic conflicts concerning occupational health and safety, discusses the nature and dimensions of health and safety problems, examines the generation of information and its diffusion, and deals briefly with some economic issues. (Author)

  14. OSHA Laboratory Standard: Driving Force for Laboratory Safety!

    ERIC Educational Resources Information Center

    Roy, Kenneth R.

    2000-01-01

    Discusses the Occupational Safety and Health Administration's (OSHA's) Laboratory Safety Standards as the major driving force in establishing and maintaining a safe working environment for teachers and students. (Author)

  15. Tank Farms Technical Safety Requirements [VOL 1 and 2

    SciTech Connect

    CASH, R.J.

    2000-12-28

    The Technical Safety Requirements (TSRs) define the acceptable conditions, safe boundaries, basis thereof, and controls to ensure safe operation during authorized activities, for facilities within the scope of the Tank Waste Remediation System (TWRS) Final Safety Analysis Report (FSAR).

  16. 78 FR 25339 - Notice of Funding Availability for the Tribal Transportation Program Safety Funds; and Request...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-30

    ...Tribal Transportation Program Safety Funds; and Request for Comments...Tribal Transportation Program Safety Funds (TTPSF) authorized...page at: http://www.archives.gov/federal_register...and Policy Considerations A. Safety Planning Activities...

  17. 33 CFR 96.240 - What functional requirements must a safety management system meet?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...requirements must a safety management system meet? The...requirements of a safety management system must include...authority and lines of communication between shoreside and...and vessel's safety management system, and the...

  18. 33 CFR 96.240 - What functional requirements must a safety management system meet?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...requirements must a safety management system meet? The...requirements of a safety management system must include...authority and lines of communication between shoreside and...and vessel's safety management system, and the...

  19. Summertime Safety

    MedlinePLUS

    ... Stages & Populations Travelers' Health Workplace Safety & Health Features Media Sign up for Features Get Email Updates To ... choose to search for a specific topic . Features Media Sign up for Features Get Email Updates To ...

  20. Antibiotic Safety

    MedlinePLUS

    ... Copyright © 2005 by The Association for Professionals in Infection Control and Epidemiology (APIC). www.apic.org Antibiotic Safety What are Antibiotics? Antibiotics are powerful medicines that help stop bacterial infections. They are used to kill germs that cause ...

  1. Fireworks Safety

    MedlinePLUS

    ... at 350 °F Water boils at 212 °F Fireworks Safety Fireworks are often used to mark special ... fireworks NFPA is opposed to consumer use of fireworks. This includes sparklers and firecrackers. Even sparklers burn ...

  2. Safety of high speed guided ground transportation systems: Magnetic and electric field testing of the Washington Metropolitan Area transit authority metrorail system. Volume 1. Analysis. Final report, September 1992-March 1993

    SciTech Connect

    Dietrich, F.M.; Papas, P.N.; Jacobs, W.L.; Ferro, W.E.

    1993-06-01

    The safety of magnetically levitated (maglev) and high speed rail (HSR) trains proposed for application in the United States is the responsibility of the Federal Railroad Administration (FRA). Plans for near future US applications include maglev technology (e.g. in Orlando, FL and Pittsburgh, PA) and high speed rail (e.g. the French Train a Grande Vitesse (TGV) in the Texas Triangle, between Dallas-Fort Worth, Houston and San Antonio, and along five designated high speed corridors). Concerns exist regarding the potential safety, environmental and health effects on the public and on transportation workers due to electrification along new or existing rail corridors, and to maglev and high speed rail operations. Therefore, the characterization of electric and magnetic fields (EMF) produced by both steady (dc) and alternating currents (ac) at power frequency (50 Hz in Europe and 60 Hz in the U.S.) and above, in the Extreme Low Frequency (ELF) range (3-3000 Hz) is of interest. An EMF survey of the Washington Metrorail (WMATA) transit system was performed, as part of a comprehensive comparative EMF safety assessment of the German Transrapid (TR-07) maglev system with other existing and advanced rail systems. The report provides the Analysis (Vol. I) of results, and detailed data and statistical summaries (Vol. II, Appendices) of representative EMF profiles on vehicles and facilities typical of this transit electrotechnology (third rail dc). EMF data represent a range of train operating conditions and locations (in vehicles, stations and waysides), as well as in traffic control and electrical power supply facilities.

  3. Older Consumers Safety Test

    MedlinePLUS

    ... Contest Toy Recall Statistics Pool Safely Home / Safety Education / Safety Guides / Home Older Consumers Safety Test This is a quiz on consumer product safety for older adults. What comes to mind when you think of Safety for the Older ...

  4. First Aid and Safety

    MedlinePLUS

    ... Outdoors A Safe and Spooktacular Halloween All-Terrain Vehicle (ATV) Safety Auto Safety Backpack Safety Booster Seat ... the Whole Family Play It Safe All-Terrain Vehicle (ATV) Safety Bike Safety How to Choose & Use ...

  5. The safety evaluation of adjuvants during vaccine development: the AS04 experience.

    PubMed

    Garçon, Nathalie; Segal, Lawrence; Tavares, Fernanda; Van Mechelen, Marcelle

    2011-06-15

    Novel adjuvants that contain immunoenhancer molecules are now present in human vaccines either registered or in clinical trials. These adjuvants have the potential to provide clear benefits in improving the magnitude and duration of various aspects of the adaptive immune response. However, the use of immunoenhancers in vaccine formulations may be perceived as introducing theoretical safety risks that need to be addressed during the course of vaccine development. In addition to classical clinical safety evaluation, the licensing authorities recommend that novel adjuvants should be evaluated in non-clinical toxicology studies, both as separate entities and as part of the final vaccine formulation. We present here our approach for the safety evaluation of adjuvanted vaccines using AS04-adjuvanted vaccines as example. This evaluation consists of three tiers: non-clinical toxicology, adjuvant mode-of-action investigations and clinical safety assessment in controlled clinical trials and post-marketing surveillance. We also discuss how the knowledge of adjuvant mode of action can support the current practice of safety evaluation. PMID:21527299

  6. PostQuantum Cryptography

    E-print Network

    Lange, Tanja

    Post­Quantum Cryptography Tanja Lange Technische Universiteit Eindhoven tanja@hyperelliptic.org 17 December 2008 Tanja Lange Post­Quantum Cryptography -- p. 1 #12; Threat of quantum computers Shor for Grover by doubling key size. Sorry, no picture available Tanja Lange Post­Quantum Cryptography -- p. 2

  7. PostQuantum Cryptography

    E-print Network

    Lange, Tanja

    Post­Quantum Cryptography Tanja Lange Technische Universiteit Eindhoven tanja@hyperelliptic.org 23 January 2013 Tanja Lange Post­Quantum Cryptography -- p. 1 #12; Threat of quantum computers Shor for Grover by doubling key size. Sorry, no picture available Tanja Lange Post­Quantum Cryptography -- p. 2

  8. Physicians Experience with and Expectations of the Safety and Tolerability of WHO-Step III Opioids for Chronic (Low) Back Pain: Post Hoc Analysis of Data from a German Cross-Sectional Physician Survey

    PubMed Central

    Ueberall, Michael A.; Eberhardt, Alice; Mueller-Schwefe, Gerhard H. H.

    2015-01-01

    Objective. To describe physicians' daily life experience with WHO-step III opioids in the treatment of chronic (low) back pain (CLBP). Methods. Post hoc analysis of data from a cross-sectional online survey with 4.283 Germany physicians. Results. With a reported median use in 17% of affected patients, WHO-step III opioids play a minor role in treatment of CLBP in daily practice associated with a broad spectrum of positive and negative effects. If prescribed, potent opioids were reported to show clinically relevant effects (such as ?50% pain relief) in approximately 3 of 4 patients (median 72%). Analgesic effects reported are frequently related with adverse events (AEs). Only 20% of patients were reported to remain free of any AE. Most frequently reported AE was constipation (50%), also graded highest for AE-related daily life restrictions (median 46%). Specific AE countermeasures were reported to be necessary in approximately half of patients (median 45%); nevertheless AE-related premature discontinuation rates reported were high (median 22%). Fentanyl/morphine were the most/least prevalently prescribed potent opioids mentioned (median 20 versus 8%). Conclusion. Overall, use of WHO-step III opioids for CLBP is low. AEs, especially constipation, are commonly reported and interfere significantly with analgesic effects in daily practice. Nevertheless, beneficial effects outweigh related AEs in most patients with CLBP. PMID:26568890

  9. Aerospace safety advisory panel

    NASA Technical Reports Server (NTRS)

    1995-01-01

    The Aerospace Safety Advisory Panel (ASAP) monitored NASA's activities and provided feedback to the NASA Administrator, other NASA officials and Congress throughout the year. Particular attention was paid to the Space Shuttle, its launch processing and planned and potential safety improvements. The Panel monitored Space Shuttle processing at the Kennedy Space Center (KSC) and will continue to follow it as personnel reductions are implemented. There is particular concern that upgrades in hardware, software, and operations with the potential for significant risk reduction not be overlooked due to the extraordinary budget pressures facing the agency. The authorization of all of the Space Shuttle Main Engine (SSME) Block II components portends future Space Shuttle operations at lower risk levels and with greater margins for handling unplanned ascent events. Throughout the year, the Panel attempted to monitor the safety activities related to the Russian involvement in both space and aeronautics programs. This proved difficult as the working relationships between NASA and the Russians were still being defined as the year unfolded. NASA's concern for the unique safety problems inherent in a multi-national endeavor appears appropriate. Actions are underway or contemplated which should be capable of identifying and rectifying problem areas. The balance of this report presents 'Findings and Recommendations' (Section 2), 'Information in Support of Findings and Recommendations' (Section 3) and Appendices describing Panel membership, the NASA response to the March 1994 ASAP report, and a chronology of the panel's activities during the reporting period (Section 4).

  10. Structural and Multidisciplinary Optimization manuscript (authors' post-print)

    E-print Network

    Sóbester, András

    Design of a Two-Stage Helical Gear Reducer Tudose, L. · Buiga, O. · S¸tefanache, C. · S´obester, A (such as service life and overall weight). Here we tackle a two-stage helical gear transmission design layouts. Keywords Evolutionary optimization · Gear train design · Spur gear sets · punctuated equilibria

  11. Note on evaluating safety performance of road infrastructure to motivate safety competition.

    PubMed

    Han, Sangjin

    2014-11-01

    Road infrastructures are usually developed and maintained by governments or public sectors. There is no competitor in the market of their jurisdiction. This monopolic feature discourages road authorities from improving the level of safety with proactive motivation. This study suggests how to apply a principle of competition for roads, in particular by means of performance evaluation. It first discusses why road infrastructure has been slow in safety oriented development and management in respect of its business model. Then it suggests some practical ways of how to promote road safety between road authorities, particularly by evaluating safety performance of road infrastructure. These are summarized as decision of safety performance indicators, classification of spatial boundaries, data collection, evaluation, and reporting. Some consideration points are also discussed to make safety performance evaluation on road infrastructure lead to better road safety management. PMID:25374273

  12. Health & Safety Program Interim

    E-print Network

    Rosebrugh, Robert

    The foundation of MtA's Health & Safety program is the Occupational Health & Safety Policy #2103. http of a joint health and safety committee (NB Occupational Health & Safety Act, Chapter 0-02) #12;Health&Safety of the employees in matters necessary to their health and safety (NB Occupational Health & Safety Act, Chapter 0

  13. The architecture of safety: hospital design

    E-print Network

    Joseph, Anjali; Rashid, Mahbub

    2007-12-01

    1 Current Opinion in Critical Care 13 (2007): 714–719 The Architecture of Safety: Hospital Design Authors: Anjali Joseph, PhD Director of Research The Center for Health Design 1850 Gateway Boulevard, Suite 1083 Concord, CA 94520 Tel: 925... of review: This article reviews the recent research literature reporting the effects of hospital design on patient safety. Recent Findings: Features of hospital design that are linked to patient safety in the literature include noise, air quality...

  14. The new politics of welfare in post-socialist Central Eastern Europe

    E-print Network

    Brown, Dana L., Ph. D. Massachusetts Institute of Technology

    2005-01-01

    This dissertation explores the evolution of welfare systems in post-socialist countries. Utilizing a range of data on social policy legislation and outcomes across countries, the author shows the extent to which post-socialist ...

  15. 21 CFR Appendix D to Subpart A of... - Criteria for Assessing Equivalence for Post- and Preapproval

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...Post- and Preapproval I. Legal/Regulatory authority and structures and procedures providing for post- and preapproval: A...documentation to enable adequate inspections. C. Ability to verify chemistry, manufacturing, and control data supporting an...

  16. 21 CFR Appendix D to Subpart A of... - Criteria for Assessing Equivalence for Post- and Preapproval

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...Post- and Preapproval I. Legal/Regulatory authority and structures and procedures providing for post- and preapproval: A...documentation to enable adequate inspections. C. Ability to verify chemistry, manufacturing, and control data supporting an...

  17. 21 CFR Appendix D to Subpart A of... - Criteria for Assessing Equivalence for Post- and Preapproval

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...Post- and Preapproval I. Legal/Regulatory authority and structures and procedures providing for post- and preapproval: A...documentation to enable adequate inspections. C. Ability to verify chemistry, manufacturing, and control data supporting an...

  18. 21 CFR Appendix D to Subpart A of... - Criteria for Assessing Equivalence for Post- and Preapproval

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...Post- and Preapproval I. Legal/Regulatory authority and structures and procedures providing for post- and preapproval: A...documentation to enable adequate inspections. C. Ability to verify chemistry, manufacturing, and control data supporting an...

  19. 21 CFR Appendix D to Subpart A of... - Criteria for Assessing Equivalence for Post- and Preapproval

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...Post- and Preapproval I. Legal/Regulatory authority and structures and procedures providing for post- and preapproval: A...documentation to enable adequate inspections. C. Ability to verify chemistry, manufacturing, and control data supporting an...

  20. Safety of daily teriparatide treatment: a post hoc analysis of a Phase III study to investigate the possible association of teriparatide treatment with calcium homeostasis in patients with serum procollagen type I N-terminal propeptide elevation

    PubMed Central

    Yamamoto, Takanori; Tsujimoto, Mika; Sowa, Hideaki

    2015-01-01

    Objective Serum procollagen type I N-terminal propeptide (PINP), a representative marker of bone anabolic action, is strongly related to bone mineral density during teriparatide therapy. This post hoc study analyzed data from a Phase III study (ClinicalTrials.gov identifier NCT00433160) to determine if there was an association between serum PINP elevation and serum calcium concentration or calcium metabolism-related disorders. Research design and methods Japanese subjects with osteoporosis at high risk of fracture were randomized 2:1 to teriparatide 20 ?g/day (n=137) or placebo (n=70) for a 12-month double-blind treatment period, followed by 12 months of open-label teriparatide treatment of all subjects. Main outcome measures Serum PINP levels were measured at baseline, and after 1, 3, 6, 12, 18, and 24 months of treatment. Serum calcium levels were measured at baseline, and after 1, 3, 6, 9, 12, 15, 18, 21, and 24 months of treatment. Results Serum PINP increased from baseline to 1 month of treatment and then remained high through 24 months. Twenty-eight of 195 subjects experienced PINP elevations >200 ?g/L during teriparatide treatment. Serum calcium concentration in both the teriparatide and placebo groups remained within the normal range. There was no clinically relevant difference in serum calcium concentration between subjects with PINP >200 ?g/L and subjects with PINP ?200 ?g/L. Two subjects experienced hypercalcemia and recovered without altering teriparatide treatment. Adverse events possibly related to calcium metabolism disorders included periarthritis calcarea (one subject) and chondrocalcinosis pyrophosphate (two subjects), but neither was accompanied with a significant increase in PINP or serum calcium concentration. Conclusion Although the moderate size of this study prevented statistical analysis of any potential association between calcium metabolism-related disorders and elevated PINP, this analysis suggests that there was no association between serum PINP elevation during daily teriparatide treatment and serum calcium concentration or calcium metabolism-related disorders in Japanese subjects. PMID:26185429

  1. Art Safety.

    ERIC Educational Resources Information Center

    BCATA Journal for Art Teachers, 1991

    1991-01-01

    Advocating that Canadian art programs should use and model environmentally safe practices, the articles in this journal focus on issues of safe practices in art education. Articles are: (1) "What is WHMIS?"; (2) "Safety Precautions for Specific Art Processes"; (3) "Toxic Substances"; (4) "Using Clay, Glazes, and Kilns Safely in the Classroom"…

  2. Playground Safety.

    ERIC Educational Resources Information Center

    Sipes, James L.

    2000-01-01

    Discusses the issues of risk, liability, and fun when landscaping playgrounds with safety in mind. The importance of playground surfaces and several preventive measures landscapers can use to reduce the risk of injury are discussed. Concluding comments address playground design features and liability. (GR)

  3. Safety Resources.

    ERIC Educational Resources Information Center

    Hoot, James L.; Bartkowiak, Elaine T.

    1994-01-01

    Lists 72 organizations and programs that deal with child safety, grouped by the following categories: (1) general; (2) general violence; (3) gun violence; (4) media violence; (5) drugs and alcohol; (6) child abuse and at-risk children; (7) parenting programs; (8) community service programs; (9) leadership programs; (10) peer counseling; (11)…

  4. School Safety.

    ERIC Educational Resources Information Center

    The Newsletter of the Comprehensive Center-Region VI, 1999

    1999-01-01

    The articles in this issue dealing with school safety discusses what rural and small urban settings are doing to prevent violence and to educate young people about prosocial alternatives to violence. The research is quite clear that female, minority, and gay students are the targets of a disproportionate amount of harassment and violence, both in…

  5. Solid waste burial grounds interim safety analysis

    SciTech Connect

    Saito, G.H.

    1994-10-01

    This Interim Safety Analysis document supports the authorization basis for the interim operation and restrictions on interim operations for the near-surface land disposal of solid waste in the Solid Waste Burial Grounds. The Solid Waste Burial Grounds Interim Safety Basis supports the upgrade progress for the safety analysis report and the technical safety requirements for the operations in the Solid Waste Burial Grounds. Accident safety analysis scenarios have been analyzed based on the significant events identified in the preliminary hazards analysis. The interim safety analysis provides an evaluation of the operations in the Solid Waste Burial Grounds to determine if the radiological and hazardous material exposures will be acceptable from an overall health and safety standpoint to the worker, the onsite personnel, the public, and the environment.

  6. Safety and Efficacy of At-Home Robotic Locomotion Therapy in Individuals with Chronic Incomplete Spinal Cord Injury: A Prospective, Pre-Post Intervention, Proof-of-Concept Study

    PubMed Central

    Rupp, Rüdiger; Schließmann, Daniel; Plewa, Harry; Schuld, Christian; Gerner, Hans Jürgen; Weidner, Norbert; Hofer, Eberhard P.; Knestel, Markus

    2015-01-01

    Background The compact Motorized orthosis for home rehabilitation of Gait (MoreGait) was developed for continuation of locomotion training at home. MoreGait generates afferent stimuli of walking with the user in a semi-supine position and provides feedback about deviations from the reference walking pattern. Objective Prospective, pre-post intervention, proof-of-concept study to test the feasibility of an unsupervised home-based application of five MoreGait prototypes in subjects with incomplete spinal cord injury (iSCI). Methods Twenty-five (5 tetraplegia, 20 paraplegia) participants with chronic (mean time since injury: 5.8 ± 5.4 (standard deviation, SD) years) sensorimotor iSCI (7 ASIA Impairment Scale (AIS) C, 18 AIS D; Walking Index for Spinal Cord Injury (WISCI II): Interquartile range 9 to 16) completed the training (45 minutes / day, at least 4 days / week, 8 weeks). Baseline status was documented 4 and 2 weeks before and at training onset. Training effects were assessed after 4 and 8 weeks of therapy. Results After therapy, 9 of 25 study participants improved with respect to the dependency on walking aids assessed by the WISCI II. For all individuals, the short-distance walking velocity measured by the 10-Meter Walk Test showed significant improvements compared to baseline (100%) for both self-selected (Mean 139.4% ± 35.5% (SD)) and maximum (Mean 143.1% ± 40.6% (SD)) speed conditions as well as the endurance estimated with the six-minute walk test (Mean 166.6% ± 72.1% (SD)). One device-related adverse event (pressure sore on the big toe) occurred in over 800 training sessions. Conclusions Home-based robotic locomotion training with MoreGait is feasible and safe. The magnitude of functional improvements achieved by MoreGait in individuals with iSCI is well within the range of complex locomotion robots used in hospitals. Thus, unsupervised MoreGait training potentially represents an option to prolong effective training aiming at recovery of locomotor function beyond in-patient rehabilitation. Trial Registration German Clinical Trials Register (DKRS) DRKS00005587 PMID:25803577

  7. Post-Keynesian Theory: An Overview.

    ERIC Educational Resources Information Center

    Kregel, J. A.

    1983-01-01

    The evolution and current position of post-Keynesian economic theory are examined. The theory is based on Keynes' exposition of effective demand in a monetary production economy determining the level of employment, rather than through supply and demand in the "real" and "monetary" sectors determining the level of real output. (Author/RM)

  8. First name Last name Post-nomials

    E-print Network

    Toronto, University of

    First name Last name Post-nomials Graduate Student/PDF Business Card Application Form Once Authorization I have reviewed the information provided and agree it is accurate. The above-named student has: _____________________________ Date: Account information Print Name: CFC: Fund:Cost Centre/Internal Order: 100 (approximately $47 tax

  9. Microbiological safety of water.

    PubMed

    Dawson, D J; Sartory, D P

    2000-01-01

    Significant advances in water treatment over the last century have resulted in massive improvements in the microbiological safety of public drinking water supplies in the UK and the developed countries. Incidences of illness due to poor treatment or post-treatment contamination are rare, but when they occur tend to attract considerable media attention. A well managed water treatment works and supply system can provide high quality drinking water wherever in the world it is located. As a rule, throughout the world, private supplies tend to be of a poorer quality than public supplies, but poorly managed public supplies have the potential to make a large number of people ill and continued effort is needed to maintain and improve drinking water quality world-wide. PMID:10885106

  10. Laboratory Safety General Safety Rules

    E-print Network

    Campbell, A. Malcolm

    . Personal Protective Equipment · All persons working with hazardous chemicals should wear gloves. · All persons working with chemicals that could be splashed in the eyes are required to wear safety goggles containers. · Discarded animals parts must be placed in a red cardboard "Biohazardous Waste" box. · Discarded

  11. Food Safety and Regulation: Evaluation of an Online Multimedia Course

    ERIC Educational Resources Information Center

    Pintauro, Stephen J.; Krahl, Augusta G.; Buzzell, Paul R.; Chamberlain, Valerie M.

    2005-01-01

    The effectiveness of, and student attitudes toward, an online Food Safety and Regulation course (WEB) were compared with lecture (LECTURE) and combined lecture/online (COMBINED) courses. All students took identical pre-tests, post-tests, and attitude assessments. No significant differences were detected in pre-test scores. Post-test results for…

  12. Workplace Safety and Health Topics: Safety & Prevention

    MedlinePLUS

    ... the NIOSH Website Workplace Safety and Health Topics Industries & Occupations Hazards & Exposures Diseases & Injuries Safety & Prevention Chemicals Emergency Preparedness & Response Publications and Products NIOSH Programs ...

  13. HEALTH, SAFETY & INTRODUCTION

    E-print Network

    Sussex, University of

    HEALTH, SAFETY & WELLBEING NEW STAFF INDUCTION #12;INTRODUCTION · University Health, Safety and Wellbeing Policy · The role of the Health & Safety Office · School/Unit Health & Safety Management · Occupational Health Services · Emergency Procedures · Fire Evacuation Procedure · Accident and incident

  14. Safety and Liability.

    ERIC Educational Resources Information Center

    Berthelot, Ronald J.; And Others

    1982-01-01

    This series of five articles highlights Pensacola Junior College's occupational safety course, involving simulated emergencies, Florida's standards for teacher liability, electrical safety in the classroom and laboratory, color coding for machine safety, and Florida industrial arts safety instructional materials. (SK)

  15. OCCUPATIONAL HEALTH AND SAFETY

    E-print Network

    OCCUPATIONAL HEALTH AND SAFETY MANAGEMENT SYSTEM Department of Occupational Health and Safety Revised December 2009 #12;Occupational Health and Safety (OHS) Management System 1. Introduction.............................................................................................................. 3 2.2 Management of Health and Safety

  16. Texas A&M University Central Texas Aviation Safety

    E-print Network

    Diestel, Geoff

    Texas A&M University Central Texas Aviation Safety ASCK 408 Fall 2012 Instructor: Dr. James will be posted on Blackboard at http://tamuct.blackboard.com Aviation Department web page: http://www.ct.tamus.edu/departments/aviation.org/UNILERT I. Overview Aviation Safety addresses issues and correlative problems that have caused aviation

  17. 9 CFR 592.120 - Authority of applicant.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Authority of applicant. 592.120 Section 592.120 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS INSPECTION VOLUNTARY INSPECTION OF EGG PRODUCTS Application for Service § 592.120 Authority of applicant. Proof of the authority of...

  18. 10 CFR 76.81 - Authorized use of radioactive material.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Authorized use of radioactive material. 76.81 Section 76.81 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS Safety § 76.81 Authorized use of radioactive material. Unless otherwise authorized by law, the...

  19. Safety harness

    DOEpatents

    Gunter, Larry W. (615 Sand Pit Rd., Leesville, SC 29070)

    1993-01-01

    A safety harness to be worn by a worker, especially a worker wearing a plastic suit thereunder for protection in a radioactive or chemically hostile environment, which safety harness comprises a torso surrounding portion with at least one horizontal strap for adjustably securing the harness about the torso, two vertical shoulder straps with rings just forward of the of the peak of the shoulders for attaching a life-line and a pair of adjustable leg supporting straps releasibly attachable to the torso surrounding portion. In the event of a fall, the weight of the worker, when his fall is broken and he is suspended from the rings with his body angled slightly back and chest up, will be borne by the portion of the leg straps behind his buttocks rather than between his legs. Furthermore, the supporting straps do not restrict the air supplied through hoses into his suit when so suspended.

  20. ATV Engineering Support Team Safety Console Preparation for the Johannes Kepler Mission

    NASA Astrophysics Data System (ADS)

    Chase, R.; Oliefka, L.

    2010-09-01

    This paper describes the improvements to be implemented in the Safety console position of the Engineering Support Team(EST) at the Automated Transfer Vehicle(ATV) Control Centre(ATV-CC) for the upcoming ATV Johannes Kepler mission. The ATV missions to the International Space Station are monitored and controlled from the ATV-CC in Toulouse, France. The commanding of ATV is performed by the Vehicle Engineering Team(VET) in the main control room under authority of the Flight Director. The EST performs a monitoring function in a room beside the main control room. One of the EST positions is the Safety console, which is staffed by safety engineers from ESA and the industrial prime contractor, Astrium. The function of the Safety console is to check whether the hazard controls are available throughout the mission as required by the Hazard Reports approved by the ISS Safety Review Panel. Safety console preparation activities were limited prior to the first ATV mission due to schedule constraints, and the safety engineers involved have been working to improve the readiness for ATV 2. The following steps have been taken or are in process, and will be described in this paper: • review of the implementation of Operations Control Agreement Documents(OCADs) that record the way operational hazard controls are performed to meet the needs of the Hazard Reports(typically in Flight Rules and Crew Procedures), • crosscheck of operational control needs and implementations with respect to ATV's first flight observations and post flight evaluations, with a view to identifying additional, obsolete or revised operational hazard controls, • participation in the Flight Rule review and update process carried out between missions, • participation in the assessment of anomalies observed during the first ATV mission, to ensure that any impacts are addressed in the ATV 2 safety documentation, • preparation of a Safety console handbook to provide lists of important safety aspects to be monitored at various stages of the mission, including links to relevant Hazard Reports, Flight Rules, and supporting documentation, • participation to training courses conducted in the frame of the ATV Training Academy(ATAC), and provision of courses related to safety for the other members of the VET and EST, • participation to simulations conducted at ATV-CC, including off-nominal cases. The result of these activities will be an improved level of readiness for the ATV 2 mission.

  1. Farm Safety

    PubMed Central

    Wilson, G. S.

    1966-01-01

    Accident and safety are related terms; the higher the accident rate in any industry, the greater is the need for safety measures designed to prevent accidents. This article discusses the accident and safety problems in agriculture, which includes horticulture and forestry. There is still a tendency among townspeople to think of the countryside as peaceful and tranquil, a place where nothing happens very quickly and far removed from violent death or crippling injury. This pleasant rustic picture has undergone a striking change in the last 30 years owing to considerable agricultural mechanization and the development of chemical pesticides, which have brought new dangers to those who live and work on the land. Although men have readily adapted themselves to new machines and methods, they have not proved as able to recognize new dangers and learn how to guard against them. In consequence, accidents have increased to such an extent that the whole industry has realized the need for positive preventive measures. In this country, it is generally accepted that an employer of labour has a responsibility to provide safe working conditions for those he employs. Farm safety legislation goes a little further and usually requires an employer to provide necessary safeguards, with the added requirement on a worker to make use of them. It is a feature of accident prevention work that it never reaches a stage when it can be regarded as complete. Even when a reduction in accidents has been achieved, the effort must be sustained or the trend will be quickly reversed. Images PMID:5904095

  2. Safety valve

    DOEpatents

    Bergman, Ulf C. (Malmoe, SE)

    1984-01-01

    The safety valve contains a resilient gland to be held between a valve seat and a valve member and is secured to the valve member by a sleeve surrounding the end of the valve member adjacent to the valve seat. The sleeve is movable relative to the valve member through a limited axial distance and a gap exists between said valve member and said sleeve.

  3. 30 CFR 56.12022 - Authorized persons at major electrical installations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Electricity § 56.12022 Authorized persons at major electrical installations. Areas containing major electrical...

  4. 30 CFR 56.12022 - Authorized persons at major electrical installations.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Electricity § 56.12022 Authorized persons at major electrical installations. Areas containing major electrical...

  5. 30 CFR 56.12022 - Authorized persons at major electrical installations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Electricity § 56.12022 Authorized persons at major electrical installations. Areas containing major electrical...

  6. 30 CFR 57.12022 - Authorized persons at major electrical installations.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-UNDERGROUND METAL AND NONMETAL MINES Electricity Surface and Underground § 57.12022 Authorized persons at major electrical installations. Areas containing...

  7. 30 CFR 56.12022 - Authorized persons at major electrical installations.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Electricity § 56.12022 Authorized persons at major electrical installations. Areas containing major electrical...

  8. 30 CFR 57.12022 - Authorized persons at major electrical installations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-UNDERGROUND METAL AND NONMETAL MINES Electricity Surface and Underground § 57.12022 Authorized persons at major electrical installations. Areas containing...

  9. 30 CFR 57.12022 - Authorized persons at major electrical installations.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-UNDERGROUND METAL AND NONMETAL MINES Electricity Surface and Underground § 57.12022 Authorized persons at major electrical installations. Areas containing...

  10. Radioisotope Laboratory Techniques Environmental Health & Safety

    E-print Network

    Slatton, Clint

    protection #12;General Lab Safety a. Absorbent paper used in designated work areas (plastic side down) b use #12;Waste Areas - Ensure appropriate catchtrays under liquids - No funnels left in liquid waste Waste Facilities Posted & Neat X Inventory up to Date X Work Areas Clean X Survey Meter Calibrated X

  11. 31 CFR 538.519 - Aircraft and maritime safety.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Aircraft and maritime safety. 538.519..., Authorizations, and Statements of Licensing Policy § 538.519 Aircraft and maritime safety. Specific licenses may... aircraft, and to ensure the safety of ocean-going maritime traffic in international waters....

  12. 31 CFR 538.519 - Aircraft and maritime safety.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Aircraft and maritime safety. 538.519..., Authorizations, and Statements of Licensing Policy § 538.519 Aircraft and maritime safety. Specific licenses may... aircraft, and to ensure the safety of ocean-going maritime traffic in international waters....

  13. 31 CFR 538.519 - Aircraft and maritime safety.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Aircraft and maritime safety. 538.519..., Authorizations, and Statements of Licensing Policy § 538.519 Aircraft and maritime safety. Specific licenses may... aircraft, and to ensure the safety of ocean-going maritime traffic in international waters....

  14. 31 CFR 538.519 - Aircraft and maritime safety.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Aircraft and maritime safety. 538.519..., Authorizations, and Statements of Licensing Policy § 538.519 Aircraft and maritime safety. Specific licenses may... aircraft, and to ensure the safety of ocean-going maritime traffic in international waters....

  15. 31 CFR 538.519 - Aircraft and maritime safety.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Aircraft and maritime safety. 538.519..., Authorizations, and Statements of Licensing Policy § 538.519 Aircraft and maritime safety. Specific licenses may... aircraft, and to ensure the safety of ocean-going maritime traffic in international waters....

  16. 46 CFR 115.910 - Passenger Ship Safety Certificate.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false Passenger Ship Safety Certificate. 115.910 Section 115... Ship Safety Certificate. (a) A vessel that carries more than 12 passengers on an international voyage must have a valid SOLAS Passenger Ship Safety Certificate. The Commandant authorizes the...

  17. Drug- and herb-induced liver injury: Progress, current challenges and emerging signals of post-marketing risk

    PubMed Central

    Raschi, Emanuel; De Ponti, Fabrizio

    2015-01-01

    Drug-induced liver injury (DILI) and herb-induced liver injury is a hot topic for clinicians, academia, drug companies and regulators, as shown by the steadily increasing number of publications in the past 15 years. This review will first provide clues for clinicians to suspect idiosyncratic (unpredictable) DILI and succeed in diagnosis. Causality assessment remains challenging and requires careful medical history as well as awareness of multifaceted aspects, especially for herbs. Drug discontinuation and therapy reconciliation remain the mainstay in patent’s management to minimize occurrence of acute liver failure. The second section will address novel agents associated with liver injury in 2014 (referred to as “signals”), especially in terms of clinical, research and drug development implications. Insights will be provided into recent trends by highlighting the contribution of different post-marketing data, especially registries and spontaneous reporting systems. This literature scrutiny suggests: (1) the importance of post-marketing databases as tools of clinical evidence to detect signals of DILI risk; and (2) the need for joining efforts in improving predictivity of pre-clinical assays, continuing post-marketing surveillance and design ad hoc post-authorization safety studies. In this context, ongoing European/United States research consortia and novel pharmaco-epidemiological tools (e.g., specialist prescription event monitoring) will support innovation in this field. Direct oral anticoagulants and herbal/dietary supplements appear as key research priorities. PMID:26167249

  18. Drug- and herb-induced liver injury: Progress, current challenges and emerging signals of post-marketing risk.

    PubMed

    Raschi, Emanuel; De Ponti, Fabrizio

    2015-07-01

    Drug-induced liver injury (DILI) and herb-induced liver injury is a hot topic for clinicians, academia, drug companies and regulators, as shown by the steadily increasing number of publications in the past 15 years. This review will first provide clues for clinicians to suspect idiosyncratic (unpredictable) DILI and succeed in diagnosis. Causality assessment remains challenging and requires careful medical history as well as awareness of multifaceted aspects, especially for herbs. Drug discontinuation and therapy reconciliation remain the mainstay in patent's management to minimize occurrence of acute liver failure. The second section will address novel agents associated with liver injury in 2014 (referred to as "signals"), especially in terms of clinical, research and drug development implications. Insights will be provided into recent trends by highlighting the contribution of different post-marketing data, especially registries and spontaneous reporting systems. This literature scrutiny suggests: (1) the importance of post-marketing databases as tools of clinical evidence to detect signals of DILI risk; and (2) the need for joining efforts in improving predictivity of pre-clinical assays, continuing post-marketing surveillance and design ad hoc post-authorization safety studies. In this context, ongoing European/United States research consortia and novel pharmaco-epidemiological tools (e.g., specialist prescription event monitoring) will support innovation in this field. Direct oral anticoagulants and herbal/dietary supplements appear as key research priorities. PMID:26167249

  19. Infusing Reliability Techniques into Software Safety Analysis

    NASA Technical Reports Server (NTRS)

    Shi, Ying

    2015-01-01

    Software safety analysis for a large software intensive system is always a challenge. Software safety practitioners need to ensure that software related hazards are completely identified, controlled, and tracked. This paper discusses in detail how to incorporate the traditional reliability techniques into the entire software safety analysis process. In addition, this paper addresses how information can be effectively shared between the various practitioners involved in the software safety analyses. The author has successfully applied the approach to several aerospace applications. Examples are provided to illustrate the key steps of the proposed approach.

  20. Laser megajoule safety issues

    SciTech Connect

    Dubost, S.; Le Tonqueze, Y.

    2008-07-15

    The Laser Megajoule (LMJ) will be an experimental fusion laser facility located at CEA-CESTA research center, close to Bordeaux. Fusion experiments will involve targets filled with tritium, requiring the design of containment devices to ensure worker protection against radiation exposure according to the French safety regulations. This paper reports the work performed by the LMJ safety team to design these confinement devices. At first, the paper describes the tritium inventory evaluated inside the facility. Then, specifications and allocations for the vacuum and air purge systems of the target bay are defined and explained. A spread model is described to evaluate the spatial repartition of the residual contamination in the chamber, concluding to an anisotropic process. Consequently, security factors have been defined according to the different locations inside the target bay. Definition of containment protections for the equipment of the target bay like fume hoods and glove boxes does not depend only on the effects of contamination (internal exposure hazards), but also on activation of materials (external exposure). Consequently, safety requirements have been defined in order to design containment devices. Finally, a specification of containment barriers performances is given (static and dynamic modes). Leakage of the barriers, negatives pressures, cleaning and conditioning are addressed. (authors)

  1. AFR-100 safety analyses

    SciTech Connect

    Sumner, T.; Moisseytsev, A.; Wei, T. Y. C.

    2012-07-01

    The Advanced Fast Reactor-100 (AFR-100) is Argonne National Laboratory's 250 MWth metal-fueled modular sodium-cooled pool-type fast reactor concept. [1] A series of accident sequences that focused on the AFR-100's ability to provide protection against reactor damage during low probability accident sequences resulting from multiple equipment failures were examined. Protected and Unprotected Loss of Flow (PLOF and ULOF) and Unprotected Transient Over-Power (UTOP) accidents were simulated using the SAS4A/SASSYS-1 safety analysis code. The large heat capacity of the sodium in the pool-type reactor allows the AFR-100 to absorb large amounts of energy during a PLOF with relatively small temperature increases throughout the system. During a ULOF with a 25-second flow halving time, coolant and cladding temperatures peak around 720 deg. C within the first minute before reactivity feedback effects decrease power to match the flow. Core radial expansion and fuel Doppler provide the necessary feedback during the UTOP to bring the system back to critical before system temperatures exceed allowable limits. Simulation results indicate that adequate ULOF safety margins exist for the AFR-100 design with flow halving times of twenty-five seconds. Significant safety margins are maintained for PLOF accidents as well as UTOP accidents if a rod stop is used. (authors)

  2. 78 FR 25916 - Authorization of Radiofrequency Equipment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-03

    ...This document proposes certain changes to the Commission's equipment authorization processes to ensure that they continue to operate efficiently and effectively. In particular, it addresses the role of TCBs in certifying RF equipment and post-market surveillance, as well as the Commission's role in assessing TCB performance. It also addresses the role of test laboratories in the RF equipment......

  3. Post-abortion mania.

    PubMed

    Sharma, Verinder; Sommerdyk, Christina; Sharma, Sapna

    2013-04-01

    We describe case histories of three women with post-abortion mania, including two women who underwent a change in diagnosis from bipolar II to bipolar I disorder and another woman who had no prior history of psychiatric disturbance. It is argued that the study of post-abortion mania should provide an opportunity to better understand the aetiology of puerperal mania. PMID:23381493

  4. ANNUAL FIRE SAFETY REPORT CAMPUS PUBLIC SAFETY

    E-print Network

    Elzanowski, Marek

    ANNUAL FIRE SAFETY REPORT 2015 CAMPUS PUBLIC SAFETY PORTLAND STATE UNIVERSITY 1914 SW PARK, SUITE 148 PORTLAND, OR 97201 DISTRIBUTED ON OCTOBER 1, 2015 #12;10/1/2015 Annual Fire Safety Report 1 ANNUAL FIRE SAFETY REPORT The report contains information about the number and location of such fires

  5. Feasibility of Virtual Reality Augmented Cycling for Health Promotion of People Post-Stroke

    PubMed Central

    Deutsch, Judith E; Myslinski, Mary Jane; Kafri, Michal; Ranky, Richard; Sivak, Mark; Mavroidis, Constantinos; Lewis, Jeffrey A

    2013-01-01

    Background and Purpose A virtual reality (VR) augmented cycling kit (VRACK) was developed to address motor control and fitness deficits of individuals with chronic stroke. In this paper we report on the safety, feasibility and efficacy of using the VRACK to train cardio-respiratory (CR) fitness of individuals in the chronic phase poststroke. Methods Four individuals with chronic stroke (47–65 years old and three or more years post-stroke), with residual lower extremity impairments (Fugl Meyer 24–26/34) who were limited community ambulators (gait speed range 0.56 to 1.1 m/s) participated in this study. Safety was defined as the absence of adverse events. Feasibility was measured using attendance, total exercise time, and “involvement” measured with the Presence Questionnaire (PQ). Efficacy of CR fitness was evaluated using a sub-maximal bicycle ergometer test before and after an 8-week training program. Results The intervention was safe and feasible with participants having 1 adverse event, 100% adherence, achieving between 90 and 125 minutes of cycling each week and a mean PQ score of 39 (SD 3.3). There was a statistically significant 13% (p = 0.035) improvement in peak VO2 with a range of 6–24.5 %. Discussion and Conclusion For these individuals post-stroke, VR augmented cycling, using their heart rate to set their avatar’s speed, fostered training of sufficient duration and intensity to promote CR fitness. In addition, there was a transfer of training from the bicycle to walking endurance. VR augmented cycling may be an addition to the therapist’s tools for concurrent training of mobility and health promotion of individuals post-stroke. Video Abstract available (see Video, Supplemental Digital Content 1) for more insights from the authors. PMID:23863828

  6. 48 CFR 23.402 - Authorities.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Authorities. 23.402 Section 23.402 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Use of Recovered Materials...

  7. 48 CFR 23.702 - Authorities.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Authorities. 23.702 Section 23.702 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Contracting...

  8. 48 CFR 23.502 - Authority.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Authority. 23.502 Section 23.502 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Drug-Free Workplace...

  9. 48 CFR 23.502 - Authority.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Authority. 23.502 Section 23.502 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Drug-Free Workplace...

  10. 48 CFR 23.201 - Authorities.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Energy and Water Efficiency and Renewable Energy 23.201 Authorities. (a) Energy... U.S.C. 6901, et seq.). (b) National Energy Conservation Policy Act (42 U.S.C. 8253, 8259b,...

  11. 48 CFR 23.201 - Authorities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Authorities. 23.201 Section 23.201 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Energy and Water...

  12. 48 CFR 23.102 - Authorities.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Authorities. 23.102 Section 23.102 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Sustainable Acquisition...

  13. 48 CFR 23.201 - Authorities.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Energy and Water Efficiency and Renewable Energy 23.201 Authorities. (a) Energy... U.S.C. 6901, et seq.). (b) National Energy Conservation Policy Act (42 U.S.C. 8253, 8259b,...

  14. 48 CFR 23.201 - Authorities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Energy and Water Efficiency and Renewable Energy 23.201 Authorities. (a) Energy... U.S.C. 6901, et seq.). (b) National Energy Conservation Policy Act (42 U.S.C. 8253, 8259b,...

  15. 48 CFR 23.201 - Authorities.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Authorities. 23.201 Section 23.201 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Energy and Water...

  16. 48 CFR 23.105 - Exemption authority.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Exemption authority. 23.105 Section 23.105 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE...

  17. 48 CFR 23.105 - Exemption authority.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Exemption authority. 23.105 Section 23.105 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE...

  18. 48 CFR 23.105 - Exemption authority.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Exemption authority. 23.105 Section 23.105 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE...

  19. A comparison of commercial/industry and nuclear weapons safety concepts

    SciTech Connect

    Bennett, R.R.; Summers, D.A.

    1996-07-01

    In this paper the authors identify factors which influence the safety philosophy used in the US commercial/industrial sector and compare them against those factors which influence nuclear weapons safety. Commercial/industrial safety is guided by private and public safety standards. Generally, private safety standards tend to emphasize product reliability issues while public (i.e., government) safety standards tend to emphasize human factors issues. Safety in the nuclear weapons arena is driven by federal requirements and memoranda of understanding (MOUs) between the Departments of Defense and Energy. Safety is achieved through passive design features integrated into the nuclear weapon. Though the common strand between commercial/industrial and nuclear weapons safety is the minimization of risk posed to the general population (i.e., public safety), the authors found that each sector tends to employ a different safety approach to view and resolve high-consequence safety issues.

  20. Bibliography on Liquefied Natural Gas (LNG) safety

    NASA Technical Reports Server (NTRS)

    Ordin, P. M.

    1976-01-01

    Approximately 600 citations concerning safety of liquefied natural gas and liquid methane are presented. Each entry includes the title, author, abstract, source, description of figures, key references, and major descriptors for retrieving the document. An author index is provided as well as an index of descriptors.

  1. Safety Grooving

    NASA Technical Reports Server (NTRS)

    1985-01-01

    Safety grooving, the cutting of grooves in concrete to increase traction and prevent injury, was first developed to reduce aircraft accidents on wet runways. Represented by the International Grooving and Grinding Association (IG&GA), the industry expanded into highway and pedestrian applications. The technique originated at Langley, which assisted in testing the grooving at airports and on highways. Skidding was reduced, stopping distance decreased, and a vehicle's cornering ability on curves was increased. The process has been extended to animal holding pens, steps, parking lots and other potentially slippery surfaces.

  2. University of Hawai'i Diving Safety Manual Appendix University of Hawaii Diving Safety Program

    E-print Network

    Wiegner, Tracy N.

    Diver Scuba Rescue Leadership (AI, Dive Master) Instructor Military Diver Commercial Diver OtherUniversity of Hawai'i Diving Safety Manual ­ Appendix University of Hawaii Diving Safety Program Appendix 1 Application for Scientific Diving Authorization Section 1. Applicant Information Date: Applicant

  3. 2013 COMPLIANCE DOCUMENT Wesleyan University 2013 Annual Campus Safety and Security/Fire Safety Report

    E-print Network

    Thomas, Ellen

    Offender Registration ­ Campus Sex Crimes Prevention Act 27 CAMPUS SECURITY POLICIES, CRIME PREVENTION OF CRIME STATISTICS 4 ABOUT THE OFFICE OF PUBLIC SAFETY 4 Role, Authority, and Training 4 Safety, Our Crimes Involving Students and Student Organizations at Off-Campus Locations 6 REPORTING CRIMES AND OTHER

  4. Expressed breast milk: safety in the hospital.

    PubMed

    Huber, Charlotte; Blanco, Mary E; Davis, Monica M

    2009-02-01

    The Pennsylvania Patient Safety Reporting System (PA-PSRS, pronounced PAY-sirs) is a confidential, statewide reporting system on the Internet to which all Pennsylvania hospitals, outpatient-surgery facilities, and birthing centers, as well as some abortion facilities, were required to file information on medical errors beginning in June 2004.Safety Monitor, this column in AJN from PA-PSRS, informs nurses on issues that can affect patient safety and presents strategies they can integrate easily into practice.For more information on PA-PSRS, visit the Web site of Pennsylvania's Patient Safety Authority, at www.psa.state.pa.us. For the original articles discussed in this column or for other articles on patient safety, click on "Advisories and Related Resources" in the left-hand navigation menu.This is a periodic column from the Pennsylvania Patient Safety Reporting System. PMID:19300003

  5. 50 CFR 38.4 - Authorized functions, powers, and duties.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...NATIONAL WILDLIFE REFUGE SYSTEM MIDWAY ATOLL NATIONAL WILDLIFE REFUGE Executive Authority...Lawful removal of person from the Midway Atoll National Wildlife Refuge for cause; ...safety of persons and property on Midway Atoll National Wildlife Refuge; and...

  6. 50 CFR 38.4 - Authorized functions, powers, and duties.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...NATIONAL WILDLIFE REFUGE SYSTEM MIDWAY ATOLL NATIONAL WILDLIFE REFUGE Executive Authority...Lawful removal of person from the Midway Atoll National Wildlife Refuge for cause; ...safety of persons and property on Midway Atoll National Wildlife Refuge; and...

  7. 50 CFR 38.4 - Authorized functions, powers, and duties.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...NATIONAL WILDLIFE REFUGE SYSTEM MIDWAY ATOLL NATIONAL WILDLIFE REFUGE Executive Authority...Lawful removal of person from the Midway Atoll National Wildlife Refuge for cause; ...safety of persons and property on Midway Atoll National Wildlife Refuge; and...

  8. 50 CFR 38.4 - Authorized functions, powers, and duties.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...NATIONAL WILDLIFE REFUGE SYSTEM MIDWAY ATOLL NATIONAL WILDLIFE REFUGE Executive Authority...Lawful removal of person from the Midway Atoll National Wildlife Refuge for cause; ...safety of persons and property on Midway Atoll National Wildlife Refuge; and...

  9. 50 CFR 38.4 - Authorized functions, powers, and duties.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...NATIONAL WILDLIFE REFUGE SYSTEM MIDWAY ATOLL NATIONAL WILDLIFE REFUGE Executive Authority...Lawful removal of person from the Midway Atoll National Wildlife Refuge for cause; ...safety of persons and property on Midway Atoll National Wildlife Refuge; and...

  10. 47 CFR 97.305 - Authorized emission types.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES AMATEUR RADIO SERVICE Technical Standards § 97.305 Authorized...types. (a) Except as specified elsewhere in this part, an amateur station may transmit a CW emission on any frequency...

  11. 47 CFR 97.305 - Authorized emission types.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES AMATEUR RADIO SERVICE Technical Standards § 97.305 Authorized...types. (a) Except as specified elsewhere in this part, an amateur station may transmit a CW emission on any frequency...

  12. 47 CFR 97.305 - Authorized emission types.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES AMATEUR RADIO SERVICE Technical Standards § 97.305 Authorized...types. (a) Except as specified elsewhere in this part, an amateur station may transmit a CW emission on any frequency...

  13. 47 CFR 97.305 - Authorized emission types.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES AMATEUR RADIO SERVICE Technical Standards § 97.305 Authorized...types. (a) Except as specified elsewhere in this part, an amateur station may transmit a CW emission on any frequency...

  14. 47 CFR 97.305 - Authorized emission types.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES AMATEUR RADIO SERVICE Technical Standards § 97.305 Authorized...types. (a) Except as specified elsewhere in this part, an amateur station may transmit a CW emission on any frequency...

  15. 49 CFR 831.9 - Authority of Board representatives.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...or related to any special investigation pertaining to safety or...incident, study, or special investigation. Authorized representatives...will conduct the test, the type of test that will be conducted...required for purposes of such investigation. (2) Any...

  16. 49 CFR 831.9 - Authority of Board representatives.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...or related to any special investigation pertaining to safety or...incident, study, or special investigation. Authorized representatives...will conduct the test, the type of test that will be conducted...required for purposes of such investigation. (2) Any...

  17. 12 CFR 1253.1 - Purpose and authority.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Banks and Banking FEDERAL HOUSING FINANCE AGENCY ENTERPRISES PRIOR APPROVAL FOR ENTERPRISE PRODUCTS... implementing the prior approval authority for enterprise products, in accordance with section 1321 of the Federal Housing Enterprises Financial Safety and Soundness Act of 1992 (Safety and Soundness Act) (12...

  18. 12 CFR 1253.1 - Purpose and authority.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Banks and Banking FEDERAL HOUSING FINANCE AGENCY ENTERPRISES PRIOR APPROVAL FOR ENTERPRISE PRODUCTS... implementing the prior approval authority for enterprise products, in accordance with section 1321 of the Federal Housing Enterprises Financial Safety and Soundness Act of 1992 (Safety and Soundness Act) (12...

  19. 12 CFR 1253.1 - Purpose and authority.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Banks and Banking FEDERAL HOUSING FINANCE AGENCY ENTERPRISES PRIOR APPROVAL FOR ENTERPRISE PRODUCTS... implementing the prior approval authority for enterprise products, in accordance with section 1321 of the Federal Housing Enterprises Financial Safety and Soundness Act of 1992 (Safety and Soundness Act) (12...

  20. 12 CFR 1253.1 - Purpose and authority.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Banks and Banking FEDERAL HOUSING FINANCE AGENCY ENTERPRISES PRIOR APPROVAL FOR ENTERPRISE PRODUCTS... implementing the prior approval authority for enterprise products, in accordance with section 1321 of the Federal Housing Enterprises Financial Safety and Soundness Act of 1992 (Safety and Soundness Act) (12...

  1. Strain balanced quantum posts

    SciTech Connect

    Alonso-Alvarez, D.; Alen, B.; Ripalda, J. M.; Llorens, J. M.; Taboada, A. G.; Briones, F.; Roldan, M. A.; Hernandez-Saz, J.; Hernandez-Maldonado, D.; Herrera, M.; Molina, S. I.

    2011-04-25

    Quantum posts are assembled by epitaxial growth of closely spaced quantum dot layers, modulating the composition of a semiconductor alloy, typically InGaAs. In contrast with most self-assembled nanostructures, the height of quantum posts can be controlled with nanometer precision, up to a maximum value limited by the accumulated stress due to the lattice mismatch. Here, we present a strain compensation technique based on the controlled incorporation of phosphorous, which substantially increases the maximum attainable quantum post height. The luminescence from the resulting nanostructures presents giant linear polarization anisotropy.

  2. [Research progress in post-fire debris flow].

    PubMed

    Di, Xue-ying; Tao, Yu-zhu

    2013-08-01

    The occurrence of the secondary disasters of forest fire has significant impacts on the environment quality and human health and safety. Post-fire debris flow is one of the most hazardous secondary disasters of forest fire. To understand the occurrence conditions of post-fire debris flow and to master its occurrence situation are the critical elements in post-fire hazard assessment. From the viewpoints of vegetation, precipitation threshold and debris flow material sources, this paper elaborated the impacts of forest fire on the debris flow, analyzed the geologic and geomorphic conditions, precipitation and slope condition that caused the post-fire debris flow as well as the primary mechanisms of debris-flow initiation caused by shallow landslide or surface runoff, and reviewed the research progress in the prediction and forecast of post-fire debris flow and the related control measures. In the future research, four aspects to be focused on were proposed, i. e., the quantification of the relationships between the fire behaviors and environmental factors and the post-fire debris flow, the quantitative research on the post-fire debris flow initiation and movement processes, the mechanistic model of post-fire debris flow, and the rapid and efficient control countermeasures of post-fire debris flow. PMID:24380363

  3. Organizational Evaluation and Authority 

    E-print Network

    Scott, Richard W.; Dornbusch, Sanford M.; Busching, Bruce C.; Laing, James D.

    2015-07-21

    The authors describe four kinds of authority rights (legitimate attempts to control others) and analyze organizational authority systems in terms of the process by which participants’ performances are evaluated. They present ...

  4. 49 CFR 382.303 - Post-accident testing.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... ALCOHOL USE AND TESTING Tests Required § 382.303 Post-accident testing. (a) As soon as practicable... employer shall test for alcohol for each of its surviving drivers: (1) Who was performing safety-sensitive... damage to any motor vehicle requiring tow away YESNO YESNO (d)(1) Alcohol tests. If a test required...

  5. 49 CFR 382.303 - Post-accident testing.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... performing safety-sensitive functions with respect to the vehicle, if the accident involved the loss of human... 49 Transportation 5 2010-10-01 2010-10-01 false Post-accident testing. 382.303 Section 382.303 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER...

  6. 30 CFR 7.91 - Post-approval product audit.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Post-approval product audit. 7.91 Section 7.91 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING, EVALUATION, AND APPROVAL OF MINING PRODUCTS TESTING BY APPLICANT OR THIRD PARTY Diesel Engines Intended for Use in Underground Coal Mines § 7.91...

  7. 9 CFR 352.11 - Post-mortem inspection.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Post-mortem inspection. 352.11 Section 352.11 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY INSPECTION AND CERTIFICATION EXOTIC ANIMALS AND...

  8. 18 CFR 12.25 - Posting and readiness.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Posting and readiness. 12.25 Section 12.25 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT SAFETY OF WATER POWER PROJECTS AND PROJECT...

  9. Post-Traumatic Stress Disorder

    MedlinePLUS

    ... t Hurt Yourself For More Information Post-Traumatic Stress Disorder (Easy-to-Read) Order a free hardcopy ... post-traumatic stress disorder. What is post-traumatic stress disorder, or PTSD? PTSD is a real illness. ...

  10. Post-Adolescent Issues

    MedlinePLUS

    COPING & HEALING CARING FOR A CHILD: POST-ADOLESCENT ISSUES As your child reaches adulthood, there will be different issues and considerations to contend with. These may include restrictions on choice of ...

  11. 3 CFR 13650 - Executive Order 13650 of August 1, 2013. Improving Chemical Facility Safety and Security

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Chemical Facility Safety and Security 13650 Order 13650 Presidential Documents Executive Orders Executive Order 13650 of August 1, 2013 EO 13650 Improving Chemical Facility Safety and Security By the authority... agencies (agencies) with regulatory authority to further improve chemical facility safety and security...

  12. Lack of adverse effects during a target animal safety trial of extended-release buprenorphine in Fischer 344 rats.

    PubMed

    Cowan, Alan; Sarabia-Estrada, Rachel; Wilkerson, Gina; McKnight, Patrick; Guarnieri, Michael

    2015-12-18

    Extended-release buprenorphine is an effective analgesic in laboratory animals, and its safety has been established in mice but not in rats. The authors used a target animal safety trial to evaluate the safety of extended-release buprenorphine in rats. Fischer 344 rats received post-surgical subcutaneous injections of 1.3 mg, 3.9 mg or 6.5 mg buprenorphine per kg body weight (two times, six times or ten times the intended dose, respectively), and their body weight, clinical signs and symptoms, clinical pathology and histopathology were monitored for 4 d. Body weight was not significantly different in rats that received buprenorphine compared with control rats. Signs of nausea-related behavior were observed in 25% of the rats treated with buprenorphine. Clinical pathology results for all rats were normal, and gross and microscopic histopathology examinations identified no substantial abnormalities, suggesting that this behavior was of minor consequence. Other adverse events previously reported to occur with opiate therapy, including weight loss and dermal lesions at drug injection sites, were not observed in this study. The results of this study show that post-surgical administration of an extended-release buprenorphine product is safe in Fischer 344 rats and does not necessarily cause substantial adverse effects, confirming that opiate therapy is a viable choice in laboratory animal medicine. PMID:26684956

  13. Ex Post Moral Hazard and Bayesian Learning in Insurance Michael Ludkovski1

    E-print Network

    Ludkovski, Mike

    Ex Post Moral Hazard and Bayesian Learning in Insurance Michael Ludkovski1 and Virginia R. Young@umich.edu 1 corresponding author #12;EX POST MORAL HAZARD AND BAYESIAN LEARNING IN INSURANCE Abstract. We study a dynamic insurance market with asymmetric information and ex post moral hazard. In our model

  14. Radiation Safety Manual Prepared by

    E-print Network

    Johnson, Eric E.

    Radiation Safety Manual Prepared by University Radiation Safety Committee in coordination with NMSU.........................................................................3 Radiation Safety Officer ....................................................................................................... 3 University Radiation Safety Committee

  15. Attentional bias toward safety predicts safety behaviors.

    PubMed

    Xu, Yaoshan; Li, Yongjuan; Wang, Guangxi; Yuan, Xiao; Ding, Weidong; Shen, Zhongxiang

    2014-10-01

    Safety studies have primarily focused on how explicit processes and measures affect safety behavior and subsequent accidents and injuries. Recently, safety researchers have paid greater attention to the role of implicit processes. Our research focuses on the role of attentional bias toward safety (ABS) in workplace safety. ABS is a basic, early-stage cognitive process involving the automatic and selective allocation of attentional resources toward safety cues, which reflect the implicit motivational state of employees regarding safety goal. In this study, we used two reaction time-based paradigms to measure the ABS of employees in three studies: two modified Stroop tasks (Studies 1 and 2) and a visual dot-probe task (Study 3). Results revealed that employees with better safety behavior showed significant ABS (Study 2), and greater ABS than employees with poorer safety behavior (Studies 1 and 2). Moreover, ABS was positively associated with the perceived safety climate and safety motivation of employees, both of which mediate the effect of ABS on safety behavior (Study 3). These results contributed to a deeper understanding of how early-stage automatic perceptual processing affects safety behavior. The practical implications of these results were also discussed. PMID:24922613

  16. 14 CFR 437.27 - Pre-flight and post-flight operations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Pre-flight and post-flight operations. 437.27 Section 437.27 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION... Experimental Permit Operational Safety Documentation § 437.27 Pre-flight and post-flight operations....

  17. Please post or circulate FENVIRONMENT, HEALTH & SAFETY INFORMATION FOR THE

    E-print Network

    Cohen, Ronald C.

    Water Pollution Prevention program. This pollution prevention program covers all water discharges Y HH SS&& EE Fact Sheet: Storm Water Pollution Prevention Page 2 of 4 There are two types storm drains discharge water--as well as the pollutants and litter it picks up--into Strawberry Creek

  18. Please post or circulate FENVIRONMENT, HEALTH & SAFETY INFORMATION FOR THE

    E-print Network

    Cohen, Ronald C.

    from chemical exposures that might affect the male reproductive system and will help prevent L E Y HH SS&& EE No. 45 (Revised: 10/26/99) Reproductive Hazards in the Laboratory Basic laboratory L E Y HH SS&& EE Fact Sheet: Reproductive Hazards in the Laboratory (continued) 5. Discuss any

  19. 49 CFR 374.107 - Notice to be posted at terminal facilities.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 5 2013-10-01 2013-10-01 false Notice to be posted at terminal facilities. 374.107 Section 374.107 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR CARRIER SAFETY REGULATIONS PASSENGER CARRIER REGULATIONS...

  20. 30 CFR 70.210 - Respirable dust samples; report to operator; posting.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Respirable dust samples; report to operator; posting. 70.210 Section 70.210 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR COAL MINE SAFETY AND HEALTH MANDATORY HEALTH STANDARDS-UNDERGROUND COAL MINES Sampling...

  1. Medical Device Safety

    MedlinePLUS

    ... More Medical Device Recalls Recent Medical Device Safety Communications FDA Safety Communication Date The FDA Recommends Health Care Providers Stop ... Inc. Surgical Convenience Packs and Trays: FDA Safety Communication 01/05/16 La FDA le recomienda a ...

  2. Authoring and GTE.

    ERIC Educational Resources Information Center

    Johnson, Robin; Sime, Julie-Ann

    1998-01-01

    Examines GTE (Generic Tutoring Environment) from an authoring perspective, describes how GTE may be used to create courseware, and reviews potential difficulties that authors face when using such a tool. Summarizes two studies that investigated how authors used GTE and concludes that GTE designs are difficult for authors to test and evaluate.…

  3. Safety in the A Vanderbilt Safety

    E-print Network

    Wikswo, John

    Health & Safety U-0211 MCN, 2665 Phone: 322-2057 www.safety.vanderbilt.edu 1 #12;Table of Contents Hazard ..................................................................................................................4 Chemicals That Can Cause Adverse Health Effects ...............................................................................................9 Skin protection

  4. Northern Campus Posting Policies MacArthur Campus Posting Policy

    E-print Network

    Fernandez, Eduardo

    Northern Campus Posting Policies MacArthur Campus Posting Policy All postings must be stamped advertising Club Activities and events MUST have the Student Development and Activities stamp prior to requesting the Housing stamp 4). Flyers must have correct grammar and spelling. 5). Preference for posting

  5. Multilingualism in Post-Soviet Countries: Language Revival, Language Removal, and Sociolinguistic Theory

    ERIC Educational Resources Information Center

    Pavlenko, Aneta

    2008-01-01

    Since the post-Soviet context is not particularly well known to the majority of readers, the author uses this introduction to provide a general background against which developments in particular post-Soviet countries can be better understood. The author begins by placing these developments in the sociohistoric context of language policies of the…

  6. 78 FR 76191 - Operational Tests and Inspections for Compliance With Maximum Authorized Train Speeds and Other...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-16

    ... Train Speeds and Other Speed Restrictions AGENCY: Federal Railroad Administration (FRA), Department of... maximum authorized train speeds and other speed restrictions. SUMMARY: FRA is issuing Safety Advisory 2013... and applicable railroad operating rules regarding maximum authorized train speed limits and...

  7. 77 FR 27442 - Recruitment of First Responder Network Authority Board of Directors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-10

    ...Administration Recruitment of First Responder Network Authority Board of Directors AGENCY...Board of Directors of the First Responder Network Authority (FirstNet). The Act created...interoperable public safety broadband network. The Board of Directors will be...

  8. 10 CFR 35.2024 - Records of authority and responsibilities for radiation protection programs.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...Records of authority and responsibilities for radiation protection programs. 35.2024 Section...of authority and responsibilities for radiation protection programs. (a) A...duties, and responsibilities of the Radiation Safety Officer as required by §...

  9. 10 CFR 35.2024 - Records of authority and responsibilities for radiation protection programs.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...Records of authority and responsibilities for radiation protection programs. 35.2024 Section...of authority and responsibilities for radiation protection programs. (a) A...duties, and responsibilities of the Radiation Safety Officer as required by §...

  10. 10 CFR 35.2024 - Records of authority and responsibilities for radiation protection programs.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...Records of authority and responsibilities for radiation protection programs. 35.2024 Section...of authority and responsibilities for radiation protection programs. (a) A...duties, and responsibilities of the Radiation Safety Officer as required by §...

  11. 20 CFR 726.115 - Revocation of authorization to self-insure.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, AS AMENDED BLACK LUNG BENEFITS; REQUIREMENTS FOR COAL MINE OPERATOR'S INSURANCE Authorization of Self-Insurers § 726.115 Revocation of authorization to...

  12. 20 CFR 726.111 - Notice of authorization to self-insure.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, AS AMENDED BLACK LUNG BENEFITS; REQUIREMENTS FOR COAL MINE OPERATOR'S INSURANCE Authorization of Self-Insurers § 726.111 Notice of authorization to...

  13. 20 CFR 726.115 - Revocation of authorization to self-insure.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... LABOR FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, AS AMENDED BLACK LUNG BENEFITS; REQUIREMENTS FOR COAL MINE OPERATOR'S INSURANCE Authorization of Self-Insurers § 726.115 Revocation of authorization...

  14. 20 CFR 726.111 - Notice of authorization to self-insure.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, AS AMENDED BLACK LUNG BENEFITS; REQUIREMENTS FOR COAL MINE OPERATOR'S INSURANCE Authorization of Self-Insurers § 726.111 Notice of authorization to...

  15. 10 CFR 35.2024 - Records of authority and responsibilities for radiation protection programs.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...Records of authority and responsibilities for radiation protection programs. 35.2024 Section...of authority and responsibilities for radiation protection programs. (a) A...duties, and responsibilities of the Radiation Safety Officer as required by §...

  16. 10 CFR 35.2024 - Records of authority and responsibilities for radiation protection programs.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...Records of authority and responsibilities for radiation protection programs. 35.2024 Section...of authority and responsibilities for radiation protection programs. (a) A...duties, and responsibilities of the Radiation Safety Officer as required by §...

  17. 33 CFR 96.420 - What authority may an organization ask for under this regulation?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...DEPARTMENT OF HOMELAND SECURITY VESSEL OPERATING REGULATIONS RULES FOR THE SAFE OPERATION OF VESSELS AND SAFETY MANAGEMENT SYSTEMS Authorization of Recognized Organizations To Act on Behalf of the U.S. § 96.420 What authority may an...

  18. 33 CFR 96.420 - What authority may an organization ask for under this regulation?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...DEPARTMENT OF HOMELAND SECURITY VESSEL OPERATING REGULATIONS RULES FOR THE SAFE OPERATION OF VESSELS AND SAFETY MANAGEMENT SYSTEMS Authorization of Recognized Organizations To Act on Behalf of the U.S. § 96.420 What authority may an...

  19. Safety analysis

    NASA Technical Reports Server (NTRS)

    Knight, John C.

    1995-01-01

    We are engaged in a research program in safety-critical computing that is based on two case studies. We use these case studies to provide application-specific details of the various research issues, and as targets for evaluation of research ideas. The first case study is the Magnetic Stereotaxis System (MSS), an investigational device for performing human neurosurgery being developed in a joint effort between the Department of Physics at the University of Virginia and the Department of Neurosurgery at the University of Iowa. The system operates by manipulating a small permanent magnet (known as a 'seed') within the brain using an externally applied magnetic field. By varying the magnitude and gradient of the external magnetic field, the seed can be moved along a non-linear path and positioned at a site requiring therapy, e.g., a tumor. The magnetic field required for movement through brain tissue is extremely high, and is generated by a set of six superconducting magnets located in a housing surrounding the patient's head. The system uses two X-ray cameras positioned at right angles to detect in real time the locations of the seed and of X-ray opaque markers affixed to the patient's skull. the X-ray images are used to locate the objects of interest in a canonical frame of reference. the second case study is the University of Virginia Research Nuclear Reactor (UVAR). It is a 2 MW thermal, concrete-walled pool reactor. The system operates using 20 to 25 plate-type fuel assemblies placed on a rectangular grid plate. There are three scramable safety rods, and one non-scramable regulating rod that can be put in automatic mode. It was originally constructed in 1959 as a 1 MW system, and it was upgraded to 2 MW in 1973. Though only a research reactor rather than a power reactor, the issues raised are significant and can be related to the problems faced by full-scale reactor systems.

  20. Farm Health and Safety

    MedlinePLUS

    ... jobs in the United States. Farms have many health and safety hazards, including Chemicals and pesticides Machinery, ... equipment can also reduce accidents. Occupational Safety and Health Administration

  1. Nuclear criticality safety guide

    SciTech Connect

    Pruvost, N.L.; Paxton, H.C.

    1996-09-01

    This technical reference document cites information related to nuclear criticality safety principles, experience, and practice. The document also provides general guidance for criticality safety personnel and regulators.

  2. Safety training methods

    NASA Astrophysics Data System (ADS)

    Revelle, J. B.

    The book provides information necessary for the design, implementation and monitoring of occupational safety training programs. The place of the safety training program within a company is discussed, and the practical aspects of safety and health training programs are considered. OSHA safety and health training requirements are examined, together with the role of the supervisor in safety training and means of training in the keeping of safety records. Consideration is then given to training for specific safety problems, including fires and obstacles, to meet OSHA and other inspection requirements. Medical and first aid training and the evaluation of the effectiveness of safety training programs are also discussed.

  3. Social Media: Fog Safety #FogSafety

    E-print Network

    Social Media: Fog Safety #FogSafety Please help the NWS spread these important safety messages a WeatherReady Nation. How Fog Forms Driving with Decreased Visibility Pulling Over When Driving In Fog Driving in Dense Fog Driving in Patchy Fog Fog and Boating Fog Products Issued by NWS

  4. FIRE SAFETY REPORT ENVIRONMENTAL HEALTH & SAFETY SERVICES

    E-print Network

    Hong, Don

    FIRE SAFETY REPORT 2014 ENVIRONMENTAL HEALTH & SAFETY SERVICES #12;1 | M T S U F I R E S A F E T Y R E P O R T FIRE SAFETY REPORT TABLE OF CONTENTS INTRODUCTION 2 RESPONSIBILITIES AND DUTIES OF THE MTSU FIRE MARSHAL 2 GENERAL 3 SMOKING POLICY 3 CLASS A COMBUSTIBLES 4 CLASS B COMBUSTIBLES 4 FIRE

  5. GSFC Safety and Mission Assurance Organization

    NASA Technical Reports Server (NTRS)

    Kelly, Michael P.

    2010-01-01

    This viewgraph presentation reviews NASA Goddard Space Flight Center's approach to safety and mission assurance. The contents include: 1) NASA GSFC Background; 2) Safety and Mission Assurance Directorate; 3) The Role of SMA-D and the Technical Authority; 4) GSFC Mission assurance Requirements; 5) GSFC Systems Review Office (SRO); 6) GSFC Supply Chain Management Program; and 7) GSFC ISO9001/AS9100 Status Brief.

  6. 49 CFR 218.61 - Authority to deactivate safety devices.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...this section. (b) If a locomotive is equipped with a device to assure that the operator is alert or not physically incapacitated, that device may be deactivated when: (1) The locomotive is not the controlling locomotive; (2) The...

  7. 49 CFR 218.61 - Authority to deactivate safety devices.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...this section. (b) If a locomotive is equipped with a device to assure that the operator is alert or not physically incapacitated, that device may be deactivated when: (1) The locomotive is not the controlling locomotive; (2) The...

  8. State of the Art: Recent Legislation on Workers' Health and Safety.

    ERIC Educational Resources Information Center

    Parmeggiani, L.

    1982-01-01

    Reviews present trends in occupational health and safety legislation. Discusses the role of the state, the development of workers' participation, trends in the organization of occupational health services, and methods and objectives of occupational safety and health. (Author/JOW)

  9. Results of Safety Inspections of College Laboratory and Chemical Storage Facilities.

    ERIC Educational Resources Information Center

    Renfrew, Malcolm M., Ed.

    1982-01-01

    Results of on-site inspections of 11 New York colleges, laboratories and storage facilities are summarized according to: (1) chemical storage and disposal; (2) safety equipment; (3) ventilation; (4) general housekeeping; and (5) safety education. (Author/SK)

  10. 33 CFR 165.1156 - Safety Zone; Offshore Marine Terminal, El Segundo, CA.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...2011-07-01 false Safety Zone; Offshore Marine Terminal, El Segundo, CA...District § 165.1156 Safety Zone; Offshore Marine Terminal, El Segundo, CA...Commercial vessels authorized to use the offshore marine terminal for loading or...

  11. 33 CFR 165.1156 - Safety Zone; Offshore Marine Terminal, El Segundo, CA.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...2010-07-01 false Safety Zone; Offshore Marine Terminal, El Segundo, CA...District § 165.1156 Safety Zone; Offshore Marine Terminal, El Segundo, CA...Commercial vessels authorized to use the offshore marine terminal for loading or...

  12. 78 FR 48224 - Lac-Mégantic Railroad Accident Discussion and DOT Safety Recommendations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-07

    ...pursuant to paragraph 19(a)(1) of the Canadian Railway Safety Act directing railroad...gantic Accident's Safety Implications Canadian authorities investigating this accident...inner shells and the use of full head shields where not already mandated by...

  13. 77 FR 16584 - Office of Hazardous Materials Safety; Notice of Applications for Modification of Special Permit

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-21

    ... From the Federal Register Online via the Government Printing Office DEPARTMENT OF TRANSPORTATION Pipeline And Hazardous Materials Safety Administration Office of Hazardous Materials Safety; Notice of...). permit to authorize the Proctor & Gamble manufacture, marking, Company) Boston, MA. sale and use...

  14. Emotion Review The Author(s) 2015

    E-print Network

    and its measurement. One challenge is that emotional arousal, when measured as sympathetic nervous system research, sympathetic nervous system (SNS) Author note: We would like to thank all participants who shared

  15. Safety Evaluation Report of the Waste Isolation Pilot Plant Contact Handled (CH) Waste Documented Safety Analysis

    SciTech Connect

    Washington TRU Solutions LLC

    2005-09-01

    This Safety Evaluation Report (SER) documents the Department of Energy’s (DOE's) review of Revision 9 of the Waste Isolation Pilot Plant Contact Handled (CH) Waste Documented Safety Analysis, DOE/WIPP-95-2065 (WIPP CH DSA), and provides the DOE Approval Authority with the basis for approving the document. It concludes that the safety basis documented in the WIPP CH DSA is comprehensive, correct, and commensurate with hazards associated with CH waste disposal operations. The WIPP CH DSA and associated technical safety requirements (TSRs) were developed in accordance with 10 CFR 830, Nuclear Safety Management, and DOE-STD-3009-94, Preparation Guide for U. S. Department of Energy Nonreactor Nuclear Safety Analysis Reports.

  16. 49 CFR 803.3 - Authority to affix Seal.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...2010-10-01 2010-10-01 false Authority to affix Seal. 803.3 Section 803.3 Transportation...NATIONAL TRANSPORTATION SAFETY BOARD OFFICIAL SEAL § 803.3 Authority to affix Seal. (a) The Seal shall be in the custody...

  17. 49 CFR 803.3 - Authority to affix Seal.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...2013-10-01 2013-10-01 false Authority to affix Seal. 803.3 Section 803.3 Transportation...NATIONAL TRANSPORTATION SAFETY BOARD OFFICIAL SEAL § 803.3 Authority to affix Seal. (a) The Seal shall be in the custody...

  18. 49 CFR 803.3 - Authority to affix Seal.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...2011-10-01 2011-10-01 false Authority to affix Seal. 803.3 Section 803.3 Transportation...NATIONAL TRANSPORTATION SAFETY BOARD OFFICIAL SEAL § 803.3 Authority to affix Seal. (a) The Seal shall be in the custody...

  19. 49 CFR 803.3 - Authority to affix Seal.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...2014-10-01 2014-10-01 false Authority to affix Seal. 803.3 Section 803.3 Transportation...NATIONAL TRANSPORTATION SAFETY BOARD OFFICIAL SEAL § 803.3 Authority to affix Seal. (a) The Seal shall be in the custody...

  20. 49 CFR 803.3 - Authority to affix Seal.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...2012-10-01 2012-10-01 false Authority to affix Seal. 803.3 Section 803.3 Transportation...NATIONAL TRANSPORTATION SAFETY BOARD OFFICIAL SEAL § 803.3 Authority to affix Seal. (a) The Seal shall be in the custody...

  1. 47 CFR 101.139 - Authorization of transmitters.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Authorization of transmitters. 101.139 Section 101.139 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Technical Standards § 101.139 Authorization of transmitters. (a) Unless specified otherwise, transmitters used in...

  2. 47 CFR 101.1311 - Initial EA license authorization.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Initial EA license authorization. 101.1311 Section 101.1311 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Multiple Address Systems System License Requirements § 101.1311 Initial EA license authorization. (a)...

  3. 47 CFR 101.31 - Temporary and conditional authorizations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 5 2013-10-01 2013-10-01 false Temporary and conditional authorizations. 101.31 Section 101.31 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Applications and Licenses General Filing Requirements § 101.31 Temporary and conditional authorizations....

  4. Bromine Safety

    SciTech Connect

    Meyers, B

    2001-04-09

    The production and handling in 1999 of about 200 million kilograms of bromine plus substantial derivatives thereof by Great Lakes Chemical Corp. and Albemarle Corporation in their southern Arkansas refineries gave OSHA Occupational Injury/Illness Rates (OIIR) in the range of 0.74 to 1.60 reportable OIIRs per 200,000 man hours. OIIRs for similar industries and a wide selection of other U.S. industries range from 1.6 to 23.9 in the most recent OSHA report. Occupational fatalities for the two companies in 1999 were zero compared to a range in the U.S.of zero for all computer manufacturing to 0.0445 percent for all of agriculture, forestry and fishing in the most recent OSHA report. These results show that bromine and its compounds can be considered as safe chemicals as a result of the bromine safety standards and practices at the two companies. The use of hydrobromic acid as an electrical energy storage medium in reversible PEM fuel cells is discussed. A study in 1979 of 20 megawatt halogen working fluid power plants by Oronzio de Nora Group found such energy to cost 2 to 2.5 times the prevailing base rate at that time. New conditions may reduce this relative cost. The energy storage aspect allows energy delivery at maximum demand times where the energy commands premium rates. The study also found marginal cost and performance advantages for hydrobromic acid over hydrochloric acid working fluid. Separate studies in the late 70s by General Electric also showed marginal performance advantages for hydrobromic acid.

  5. Reactor Safety Research Programs

    SciTech Connect

    Dotson, CW

    1980-08-01

    This document summarizes the work performed by Pacific Northwest laboratory from October 1 through December 31, 1979, for the Division of Reactor Safety Research within the Nuclear Regulatory Commission. Evaluation of nondestructive examination (NDE) techniques and instrumentation are reported; areas of investigation include demonstrating the feasibilty of determining structural graphite strength, evaluating the feasibilty of detecting and analyzing flaw growth in reactor pressure boundary systems, examining NDE reliability and probabilistic fracture mechanics, and assessing the remaining integrity of pressurized water reactor steam generator tubes where service-induced degradation has been indicated. Test assemblies and analytical support are being provided for experimental programs at other facilities. These programs include the loss-of-coolant accident simulation tests at the NRU reactor, Chalk River, Canada; the fuel rod deformation and post-accident coolability tests for the ESSOR Test Reactor Program, lspra, Italy; the blowdown and reflood tests in the test facility at Cadarache, France; the instrumented fuel assembly irradiation program at Halden, Norway; and the experimental programs at the Power Burst Facility, Idaho National Engineering Laboratory. These programs will provide data for computer modeling of reactor system and fuel performance during various abnormal operating conditions.

  6. Nuclear Powerplant Safety: Operations.

    ERIC Educational Resources Information Center

    Department of Energy, Washington, DC. Nuclear Energy Office.

    Powerplant systems and procedures that ensure the day-to-day health and safety of people in and around the plant is referred to as operational safety. This safety is the result of careful planning, good engineering and design, strict licensing and regulation, and environmental monitoring. Procedures that assure operational safety at nuclear…

  7. Safety Standards for Projectors.

    ERIC Educational Resources Information Center

    Wyman, Raymond

    1979-01-01

    The safety of projectors and related viewing devices for school, home, and business use is of paramount importance. The Advisory Committee on Safety (ACOS) of the International Electrotechnical Commission (IEC) has established a working group to consider the problem of projector safety and to make recommendations for safety standards. (CMV)

  8. Better Science Through Safety.

    ERIC Educational Resources Information Center

    Gerlovich, Jack A.; Downs, Gary E.

    Following a brief description of the major components found effective in school safety programs (safety management, education, and services) and data on school accidents in Iowa, this book addresses various aspects of safety related to science instruction, emphasizing that responsibility for safety must be shared by both teacher and students.…

  9. The dragon's tail: Radiation safety in the Manhattan Project

    SciTech Connect

    Hacker, B.C.

    1987-01-01

    The book's contents are: Introduction: radiation safety in World War II. Foundations of Manhattan Project radiation safety. Role of the Chicago Health Division. Radiation safety at Los Alamos, Trinity. From Japan to Bikini. Crossroads. Epilogue: continuity and change in radiation safety. Appendix: chronological index of radiation exposure standards. Index. The United States Department of Energy and the Energy Research and Development Administration financially supported this book which provides a historical account of radiological safety in nuclear weapons testing during World War II. The author relied on archival sources and the oral testimony of participants and eyewitnesses. He provides a bibliography with full citations.

  10. Authorization basis requirements comparison report

    SciTech Connect

    Brantley, W.M.

    1997-08-18

    The TWRS Authorization Basis (AB) consists of a set of documents identified by TWRS management with the concurrence of DOE-RL. Upon implementation of the TWRS Basis for Interim Operation (BIO) and Technical Safety Requirements (TSRs), the AB list will be revised to include the BIO and TSRs. Some documents that currently form part of the AB will be removed from the list. This SD identifies each - requirement from those documents, and recommends a disposition for each to ensure that necessary requirements are retained when the AB is revised to incorporate the BIO and TSRs. This SD also identifies documents that will remain part of the AB after the BIO and TSRs are implemented. This document does not change the AB, but provides guidance for the preparation of change documentation.

  11. Patient safety goals for the proposed Federal Health Information Technology Safety Center.

    PubMed

    Sittig, Dean F; Classen, David C; Singh, Hardeep

    2015-03-01

    The Office of the National Coordinator for Health Information Technology is expected to oversee creation of a Health Information Technology (HIT) Safety Center. While its functions are still being defined, the center is envisioned as a public-private entity focusing on promotion of HIT related patient safety. We propose that the HIT Safety Center leverages its unique position to work with key administrative and policy stakeholders, healthcare organizations (HCOs), and HIT vendors to achieve four goals: (1) facilitate creation of a nationwide 'post-marketing' surveillance system to monitor HIT related safety events; (2) develop methods and governance structures to support investigation of major HIT related safety events; (3) create the infrastructure and methods needed to carry out random assessments of HIT related safety in complex HCOs; and (4) advocate for HIT safety with government and private entities. The convening ability of a federally supported HIT Safety Center could be critically important to our transformation to a safe and effective HIT enabled healthcare system. PMID:25332353

  12. Building a safety and quality culture in healthcare: where it starts.

    PubMed

    Flemons, W Ward; Feasby, Thomas E; Wright, Bruce

    2011-01-01

    Healthcare in Canada underachieves stakeholders' expectations for safe, high-quality care. The authors maintain that a common understanding of, and vision for, what is required to achieve improved outcomes for patients is missing. Educating tomorrow's healthcare professionals is paramount to address this critical shortfall. However, healthcare educational institutions must themselves break out of a 20th-century paradigm of viewing healthcare safety and quality as functions of individual healthcare providers rather than as properties of the clinical micro- and meso-systems within which they function and are a part. Canadian healthcare systems are ailing; like treating a sick patient, interventions should be grounded on a solid understanding of anatomy (structure) and physiology (function). The Healthcare Encounter Safety and Quality Model (HESQM) highlights the structures underlying healthcare delivery and the key system functions required to achieve safe, high-quality care. The model has been used to frame the University of Calgary Faculty of Medicine's educational strategy for achieving safer, higher-quality care. The HESQM is based on leadership - leaders whose decisions and actions are guided by core safety and quality principles. Today's and especially tomorrow's healthcare leaders require a common understanding of how to achieve higher-performing healthcare systems; it is the responsibility of Canada's post-secondary institutions to deliver it. PMID:21952026

  13. Launch Services Safety Overview

    NASA Technical Reports Server (NTRS)

    Loftin, Charles E.

    2008-01-01

    NASA/KSC Launch Services Division Safety (SA-D) services include: (1) Assessing the safety of the launch vehicle (2) Assessing the safety of NASA ELV spacecraft (S/C) / launch vehicle (LV) interfaces (3) Assessing the safety of spacecraft processing to ensure resource protection of: - KSC facilities - KSC VAFB facilities - KSC controlled property - Other NASA assets (4) NASA personnel safety (5) Interfacing with payload organizations to review spacecraft for adequate safety implementation and compliance for integrated activities (6) Assisting in the integration of safety activities between the payload, launch vehicle, and processing facilities

  14. Post trauma abdominal cocoon

    PubMed Central

    Kaur, Supreet; Doley, Rudra Prasad; Chabbhra, Mohinish; Kapoor, Rajeev; Wig, Jaidev

    2014-01-01

    Abdominal cocoon or sclerosing peritonitis refers to a rare cause of intestinal obstruction due to formation of a membrane encasing the bowel. We report a case of abdominal cocoon post blunt trauma abdomen. The patient presented with a history of subacute intestinal obstruction and a mobile abdomen lump. Abdominal cocoon was diagnosed on computed tomography. He underwent adhesiolysis with excision of membrane. PMID:25590647

  15. Authority in Engineering Education

    ERIC Educational Resources Information Center

    Stephan, Karl D.

    2012-01-01

    Authority as a philosophical concept is defined both in general and as it applies to engineering education. Authority is shown to be a good and necessary part of social structures, in contrast to some cultural trends that regard it as an unnecessary and outmoded evil. Technical, educational, and organizational authority in their normal functions…

  16. Quality and Safety Matter

    NASA Astrophysics Data System (ADS)

    Manha, William D.

    2010-09-01

    One to the expressions for the most demanding quality was made by a well-known rocket scientist, for which this center was named, Dr. Wernher Von Braun in the Foreword of a book about the design of rocket engines that was first published by NASA in 1967: “Success in space demands perfection. Many of the brilliant achievements made in this vast, austere environment seem almost miraculous. Behind each apparent miracle, however, stands the flawless performance of numerous highly complex systems. All are important. The failure of only one portion of a launch vehicle or spacecraft may cause failure of an entire mission. But the first to feel this awesome imperative for perfection are the propulsion systems, especially the engines. Unless they operate flawlessly first, none of the other systems will get a chance to perform in space. Perfection begins in the design of space hardware. This book emphasizes quality and reliability in the design of propulsion and engine systems. It draws deeply from the vast know-how and experience which have been the essence of several well-designed, reliable systems of the past and present. And, with a thoroughness and completeness not previously available, it tells how the present high state of reliability, gained through years of research and testing, can be maintained, and perhaps improved, in engines of the future. As man ventures deeper into space to explore the planets, the search for perfection in the design of propulsion systems will continue.” Some catastrophes with losses of life will be compared to show lapses in quality and safety and contrasted with a catastrophe without loss of life because of compliance with safety requirements. 1. October 24, 1960,(USSR) Nedelin Catastrophe, Death on the Steppes, 124 deaths 2. October 25, 1966,(USA) North American Rockwell, Apollo Block I Service Module Service(SM) Propulsion System fuel tank explosion/fire and destruction of SM and test cell, test engineer/conductor/author, Bill Manha,(the presenter) 0 injuries, 0 deaths 3. March 18, 1980,(USSR) Vostok 8A92M booster pad explosion, 48 deaths. 4. August 22, 2003,(Brazil) -Alcantara VLS -1, V03. Solid rocket ignited on pad, 21 deaths 5. Summer of 2006(USA) a payload organization inquired about requirements to fly a satellite with a new “safe” SpaceDev hybrid propulsion system using a solid polymer as the fuel and nitrous oxide as the oxidizer. The extensive titanium/nitrous oxide materials compatibility testing that was required discouraged the payload organization from further exploration of using the Shuttle as the launch vehicle. 6. July 26, 2007(USA) SpaceShipTwo nitrous oxide explosion, 3 seriously injured, 3 deaths The above listed catastrophic failures resulted in 210 deaths, but there were none on the Apollo SM explosion because of compliance with CalOSHA. This is an applied lesson learned of the Shuttle. Safety was not jeopardized without extensive materials compatibility testing. On the other hand, the nitrous oxide was erroneously identified as safe for launch from Shuttle or ISS which resulted in a catastrophic explosion and resulted in 3 major injuries, and 3 deaths. This is a testimony of a survivor of a catastrophic failure where safety rules were followed and the application of the lesson learned which confirmed safety and quality, as expressed by Von Braun, PERFECTION and SAFETY do MATTER!

  17. Formal testing and utilization of streaming media to improve flight crew safety knowledge.

    PubMed

    Bellazzini, Marc A; Rankin, Peter M; Quisling, Jason; Gangnon, Ronald; Kohrs, Mike

    2008-01-01

    Increased concerns over the safety of air medical transport have prompted development of novel ways to increase safety. The objective of our study was to determine if an Internet streaming media safety video increased crew safety knowledge. 23 out of 40 crew members took an online safety pre-test, watched a safety video specific to our program and completed immediate and long-term post-testing 6 months later. Mean pre-test, post-test and 6 month follow up test scores were 84.9%, 92.3% and 88.4% respectively. There was a statistically significant difference in all scores (p safety training in our study. PMID:18328972

  18. Improving Safety through Human Factors Engineering.

    PubMed

    Siewert, Bettina; Hochman, Mary G

    2015-10-01

    Human factors engineering (HFE) focuses on the design and analysis of interactive systems that involve people, technical equipment, and work environment. HFE is informed by knowledge of human characteristics. It complements existing patient safety efforts by specifically taking into consideration that, as humans, frontline staff will inevitably make mistakes. Therefore, the systems with which they interact should be designed for the anticipation and mitigation of human errors. The goal of HFE is to optimize the interaction of humans with their work environment and technical equipment to maximize safety and efficiency. Special safeguards include usability testing, standardization of processes, and use of checklists and forcing functions. However, the effectiveness of the safety program and resiliency of the organization depend on timely reporting of all safety events independent of patient harm, including perceived potential risks, bad outcomes that occur even when proper protocols have been followed, and episodes of "improvisation" when formal guidelines are found not to exist. Therefore, an institution must adopt a robust culture of safety, where the focus is shifted from blaming individuals for errors to preventing future errors, and where barriers to speaking up-including barriers introduced by steep authority gradients-are minimized. This requires creation of formal guidelines to address safety concerns, establishment of unified teams with open communication and shared responsibility for patient safety, and education of managers and senior physicians to perceive the reporting of safety concerns as a benefit rather than a threat. (©)RSNA, 2015. PMID:26466179

  19. 10. FLOOR 1; CENTER POST AND POSTS UNDER STONE BEAMS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. FLOOR 1; CENTER POST AND POSTS UNDER STONE BEAMS WHICH SUPPORT BRIDGE BEAMS FOR BRIDGE TREES; WEDGES FOR ADJUSTING HEIGHT OF BRIDGE TREE CAN BE SEEN - Shelter Island Windmill, Manwaring Road, Shelter Island, Suffolk County, NY

  20. 1. Post card view of the bridge, c. 1910. Post ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Post card view of the bridge, c. 1910. Post card courtesy Carol Poh Miller. Photocopy by Berni Rich, Score Photographers Cleveland, OH - B & O Railroad Bridge Number 464, Spanning Old Ship Canal & Cuyahoga River, Cleveland, Cuyahoga County, OH