Sample records for post authorization safety

  1. Training in Post-authorization Pharmacovigilance.

    PubMed

    Ahuja, Vivek; Sharma, Varun

    2010-04-01

    Post-authorization pharmacovigilance refers to all the activities relating to the detection, assessment, understanding and prevention of adverse effects or any other drug-related problems, from the time a product gets the authorization to be marketed in a territory. The ultimate objective of pharmacovigilance is patient safety. To ensure this, any responsible pharmaceutical company will readily vouch for the importance of all these activities, each requiring specific training for efficient and effective execution. Having a well planned job specific training curriculum can help the organization realize its goals and objectives by covering the gaps between current and desired job performance levels and existing competencies of its employees. Apart from this, trainings can help in problem solving, increasing productivity and prepare for and respond to future changes in the organization or job duties. As the pharmaceutical business continues to grow, increasing numbers of skilled people are required to manage resultant increase in pharmacovigilance activities to remain compliant. Thus, the need for training qualified resources to develop into highly skilled pharmacovigilance professionals is the need of the hour. Currently, the supply-demand situation for skilled manpower is highly skewed in favor of the demand, as this field is relatively new in India and elsewhere. It is interesting to note that not many resources, be it internet, literature or books, are available specifically addressing the need of the industry to guide them on training requirements to set up and maintain a competent pharmacovigilance department. This article aims to present a comprehensive perspective on the trainings required in the post authorization scenario pertaining to pharmacovigilance activities and suggest ways to manage these in an efficient way so as to be compliant with the global norms and best practices. PMID:21829787

  2. 40 CFR 170.135 - Posted pesticide safety information.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...2010-07-01 2010-07-01 false Posted pesticide safety information. 170.135 Section...ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS WORKER PROTECTION STANDARD...Standard for Workers § 170.135 Posted pesticide safety information. (a)...

  3. 40 CFR 170.135 - Posted pesticide safety information.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...2011-07-01 2011-07-01 false Posted pesticide safety information. 170.135 Section...ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS WORKER PROTECTION STANDARD...Standard for Workers § 170.135 Posted pesticide safety information. (a)...

  4. Lightning Safety Awareness Week 2012 Page 1 Blog Post Template

    E-print Network

    Lightning Safety Awareness Week 2012 Page 1 Blog Post Template Posted by: Be a Force of Nature during Lightning Safety Awareness Week This week is the 12th Lightning Safety Awareness Week. Since the campaign began, the average number of lightning deaths in the U.S. has decreased from 73 to 54. That

  5. The relative burden of haemophilia A and the impact of target joint development on health-related quality of life: results from the ADVATE Post-Authorization Safety Surveillance (PASS) study.

    PubMed

    Klamroth, R; Pollmann, H; Hermans, C; Faradji, A; Yarlas, A S; Epstein, J D; Ewenstein, B M

    2011-05-01

    Studies with haemophilia A (HA) patients have shown burden in health-related quality of life (HRQOL) when compared with general population norms. In the current study, HA patients' SF-36v2 health survey scores were compared with general population norms and to patients with other chronic conditions. The impact of target joints (TJs) on HRQOL was also examined. The sample was a subset of HA patients enrolled in the Post-Authorization Safety Surveillance (PASS) programme: a prospective open-label study in which ADVATE [Antihaemophilic Factor (Recombinant), Plasma/Albumin-Free Method] was prescribed. A total of 205 patients who were ? 18 years old and had SF-36v2 baseline scores were selected for this study. To measure the burden of HA on HRQOL, manova analyses compared these SF-36v2 scores to age- and gender-matched general population US and EU norms and to patients from other chronic condition groups. manova and correlational analyses examined the relations among TJ, age and SF-36v2 scores. Comparisons with general population norms confirm that HA negatively impacts physical, but not mental, HRQOL. Comparison with other chronic conditions shows the physical burden of HA is greater than for chronic back pain but similar to diabetes and rheumatoid arthritis, while the mental burden of HA is less than for all three patient groups. The presence of TJs was negatively associated with physical HRQOL, although this association was much larger for older patients (45+ years) than for younger ones. Physical, but not mental, HRQOL is diminished in HA patients. Target joints are associated with lower physical HRQOL, although this effect is moderated by age. PMID:21332888

  6. 40 CFR 170.235 - Posted pesticide safety information.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...2010-07-01 2010-07-01 false Posted pesticide safety information. 170.235 Section...ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS WORKER PROTECTION STANDARD Standard for Pesticide Handlers § 170.235 Posted...

  7. 40 CFR 170.235 - Posted pesticide safety information.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...2011-07-01 2011-07-01 false Posted pesticide safety information. 170.235 Section...ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS WORKER PROTECTION STANDARD Standard for Pesticide Handlers § 170.235 Posted...

  8. 49 CFR 390.209 - Pre-authorization safety audit.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...SAFETY REGULATIONS; GENERAL Unified Registration System § 390.209 Pre-authorization safety audit. A non-North America-domiciled motor carrier seeking to provide transportation of property or passengers in interstate commerce within...

  9. [Post-authorization research, registries, and drug development].

    PubMed

    Patarnello, Francesca; Recchia, Giuseppe

    2013-06-01

    In the last decade regulators, payers and health care providers tried to react to three major problems in drug development and drug use in clinical practice: the pharmaceutical R&D productivity crisis, the immaturity of benefit-risk profile for several newly approved drugs and the overall impact on economic sustainability of reimbursing new high cost drugs in their systems. The potentiality of create a continuum between the evidence requirements relevant for registration, for reimbursement and for post authorization research is clear. All different parties involved, like regulators, HTA agencies, scientific communities and manufacturers, are working to improve the knowledge profile of new drugs in order to anticipate the patient access to innovation, limiting or preventing the clinical and economical risks deriving from an incomplete safety and effectiveness profile. The Italian example of "New Drugs AIFA Registries", with or without the application of risk sharing schemes (cost sharing, pay for performance, etc.), introduced a new process and increased the sensitivity on this topic. However this might probably represents only a partial answer to the problem of how to set up the governance of coverage with evidence, drug utilization monitoring, comparative effectiveness research, outcome research programs and may be how to link them to access, pricing and reimbursement. The step change in post authorization research could be to "integrate" different sources and stakeholders in a wider and continuous approach, in a well designed and inclusive "second generation" HTA approach, where all resources (competencies, data, funding) will concur to increase the evidence profile and reduce the risks, and where any "evidence generation approach" is really compliant with the standard and rules of best research practices. PMID:23801233

  10. DARHT: INTEGRATION OF AUTHORIZATION BASIS REQUIREMENTS AND WORKER SAFETY

    Microsoft Academic Search

    D. A. MC CLURE; C. A. NELSON; R. L. BOUDRIE

    2001-01-01

    This document describes the results of consensus agreements reached by the DARHT Safety Planning Team during the development of the update of the DARHT Safety Analysis Document (SAD). The SAD is one of the Authorization Basis (AB) Documents required by the Department prior to granting approval to operate the DARHT Facility. The DARHT Safety Planning Team is lead by Mr.

  11. Author's personal copy Gasoline prices and traffic safety in Mississippi

    E-print Network

    Levinson, David M.

    Author's personal copy Gasoline prices and traffic safety in Mississippi Guangqing Chi a, , Arthur November 2010 Keywords: Gasoline prices Traffic crashes Traffic safety Age Gender Race Problem: Limited literature suggests that gasoline prices have substantial effects on reducing fatal crashes. However

  12. Post-Approval Drug Safety Surveillance

    PubMed Central

    Amatya, Anup K.; Hur, Kwan; Marcus, Sue M.; Bhaumik, Dulal K.; Mann, J. John

    2009-01-01

    Following the drug-approval process, concerns remain regarding the safety of new drugs that are introduced into the marketplace. In the case of rare adverse events, the number of subjects that are treated in randomized controlled trials is invariably inadequate to determine the safety of the new pharmaceutical. Identifying safety signals for new and/or existing drugs is a major priority in the protection of public health. Unfortunately, design, analysis, and available data are often quite limited for detecting in a timely fashion any potentially harmful effects of drugs. In this review, we examine a variety of approaches for determining the possibility of adverse drug reactions. Our review includes spontaneous reports, meta-analysis of randomized controlled clinical trials, ecological studies, and analysis of medical claims data. We consider both experimental design and analytic problems as well as potential solutions. Many of these methodologies are then illustrated through application to data on the possible relationship between taking antidepressants and increased risk of suicidality. PMID:20070192

  13. Tensoral for post-processing users and simulation authors

    NASA Technical Reports Server (NTRS)

    Dresselhaus, Eliot

    1993-01-01

    The CTR post-processing effort aims to make turbulence simulations and data more readily and usefully available to the research and industrial communities. The Tensoral language, which provides the foundation for this effort, is introduced here in the form of a user's guide. The Tensoral user's guide is presented in two main sections. Section one acts as a general introduction and guides database users who wish to post-process simulation databases. Section two gives a brief description of how database authors and other advanced users can make simulation codes and/or the databases they generate available to the user community via Tensoral database back ends. The two-part structure of this document conforms to the two-level design structure of the Tensoral language. Tensoral has been designed to be a general computer language for performing tensor calculus and statistics on numerical data. Tensoral's generality allows it to be used for stand-alone native coding of high-level post-processing tasks (as described in section one of this guide). At the same time, Tensoral's specialization to a minute task (namely, to numerical tensor calculus and statistics) allows it to be easily embedded into applications written partly in Tensoral and partly in other computer languages (here, C and Vectoral). Embedded Tensoral, aimed at advanced users for more general coding (e.g. of efficient simulations, for interfacing with pre-existing software, for visualization, etc.), is described in section two of this guide.

  14. An open-label, non-comparative, non-interventional, multi-center, post-authorization safety study on the administration of rabeprazole to adults with gastro-esophageal reflux disease

    PubMed Central

    Zouboulis-Vafiadis, Irini; Paraskevas, Emmanuel; Tzourmakliotis, Dimitrios; Hatzikyriakou, Maria; Mestoussi, Angeliki; Vasdekis, Vassilios; Katsilabros, Nikolaos; Arhimandritis, Athanasios; Papadokostopoulou, Alexandra

    2014-01-01

    Background Rabeprazole produces a profound and long-lasting inhibition of gastric acid secretion. The aim of the study was to monitor the safety and efficacy of rabeprazole administered to patients with erosive or symptomatic non-erosive reflux disease, in real-life healthcare settings. Methods Male and female patients, aged ?18 years, with endoscopy diagnosed GERD were included; patients received at least 8 weeks treatment with rabeprazole. Changes in severity of symptoms recorded on the Likert scale were analysed using marginal homogeneity tests. Results 186 patients were enrolled across 17 study sites; 127 patients (68.3%) completed the study. Almost 75% of patients had an initial diagnosis of GERD with Grade A or B esophagitis. The most commonly reported adverse events (AEs) were diarrhea, flatulence, dizziness, cough, abdominal pain, upper abdominal pain and somnolence. Over half of AEs were unrelated to study drug; 1 severe AE of diarrhea was possibly related to study drug. No new AEs were reported not included in the current version of Summary of Product Characteristics. Rabeprazole was effective in reducing the symptoms of GERD; the Likert scale scores of symptoms decreased significantly for all patients from 0-4 weeks and 4-8 weeks. Conclusions In our study, rabeprazole was safe and effective in reducing the symptoms of GERD. PMID:24732963

  15. DARHT: INTEGRATION OF AUTHORIZATION BASIS REQUIREMENTS AND WORKER SAFETY

    SciTech Connect

    D. A. MC CLURE; C. A. NELSON; R. L. BOUDRIE

    2001-04-01

    This document describes the results of consensus agreements reached by the DARHT Safety Planning Team during the development of the update of the DARHT Safety Analysis Document (SAD). The SAD is one of the Authorization Basis (AB) Documents required by the Department prior to granting approval to operate the DARHT Facility. The DARHT Safety Planning Team is lead by Mr. Joel A. Baca of the Department of Energy Albuquerque Operations Office (DOE/AL). Team membership is drawn from the Department of Energy Albuquerque Operations Office, the Department of Energy Los Alamos Area Office (DOE/LAAO), and several divisions of the Los Alamos National Laboratory. Revision 1 of the DARHT SAD had been written as part of the process for gaining approval to operate the Phase 1 (First Axis) Accelerator. Early in the planning stage for the required update of the SAD for the approval to operate both Phase 1 and Phase 2 (First Axis and Second Axis) DARHT Accelerator, it was discovered that a conflict existed between the Laboratory approach to describing the management of facility and worker safety.

  16. 77 FR 10666 - Pipeline Safety: Post Accident Drug and Alcohol Testing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-23

    ...Pipeline Safety: Post Accident Drug and Alcohol Testing AGENCY: Pipeline and Hazardous...facilities to conduct post- accident drug and alcohol tests of covered employees. Within the...or incident, operators must drug and alcohol test each covered employee whose...

  17. Safety studies of post-surgical buprenorphine therapy for mice.

    PubMed

    Traul, Karl A; Romero, Jennell B; Brayton, Cory; DeTolla, Louis; Forbes-McBean, Nadine; Halquist, Matthew S; Karnes, H Thomas; Sarabia-Estrada, Rachel; Tomlinson, Michael J; Tyler, Betty M; Ye, Xiaobu; Zadnik, Patricia; Guarnieri, Michael

    2014-10-10

    The use of appropriate analgesia in laboratory mice may be suboptimal because of concerns about adverse events (AE). Target Animal Safety trials were conducted to determine the safety of an extended-release suspension of buprenorphine. Drug or control suspensions were injected subcutaneously in surgically-treated BALB/c mice anesthetized with ketamine-xylazine to mimic post-operative conditions in which the compound might commonly be administered. Single and repeat five-fold (5×) excesses of the 3.25?mg/kg intended dose were used to provoke potential AE. Trials included prospective measurements of weight changes, blood chemistry, hematology, and histopathology. Clinical and histopathology findings were similar in drug-treated and control mice in a four-day trial using a single 16.25?mg/kg, 5× overdose of the drug. In a 12-day trial, which used a total buprenorphine dose of 48.75?mg/kg, clinical and histopathology values were also similar in control and drug-treated female mice. In the male arm of the repeat-overdose trial, two of eight mice died on the morning of day 12, three days following the third 16.25?mg/kg overdose administration. Histopathology did not reveal a cause of death. In a 14-month trial using a single 3.25?mg/kg dose of the drug, no significant findings identified potential AE. These findings indicate a high tolerance to an extended-release buprenorphine suspension administered post-operatively in mice with appropriate husbandry. PMID:25305141

  18. Reevaluating nuclear safety and security in a post 9/11 era.

    SciTech Connect

    Booker, Paul M.; Brown, Lisa M.

    2005-07-01

    This report has the following topics: (1) Changing perspectives on nuclear safety and security; (2) Evolving needs in a post-9/11 era; (3) Nuclear Weapons--An attractive terrorist target; (4) The case for increased safety; (5) Evolution of current nuclear weapons safety and security; (6) Integrated surety; (7) The role of safety and security in enabling responsiveness; (8) Advances in surety technologies; and (9) Reevaluating safety.

  19. Nuclear Energy in Asia: Safety Post-Fukushima

    Microsoft Academic Search

    Takako Kimura

    2012-01-01

    Ensuring nuclear safety has been an ongoing and significant concern worldwide. Although the Fukushima Daiichi nuclear power plant accident has undermined public confidence in its safety, many of Asia's emerging economies still have plans to introduce nuclear energy. This paper analyzes the possible development of nuclear energy in Asia's emerging economies and considers the implications for nuclear safety. The analysis

  20. 7 CFR 735.10 - Posting of certificates of licensing, certificates of authorization or other USWA documents.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... false Posting of certificates of licensing, certificates of authorization or other...735.10 Posting of certificates of licensing, certificates of authorization or other...receipt of their certificate of service licensing or any modification or extension...

  1. Morganza to the Gulf of Mexico, Louisiana Post Authorization Change Report and

    E-print Network

    US Army Corps of Engineers

    of the Chief of Engineers updating the authorized Morganza to the Gulf of Mexico project. The Louisiana Coastal#12;1 Morganza to the Gulf of Mexico, Louisiana Post Authorization Change Report and Revised of Mexico, Louisiana (Morganza to the Gulf) hurricane and storm damage reduction project for construction

  2. 49 CFR 218.61 - Authority to deactivate safety devices.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    (a) For the purpose of this chapter, it is lawful to temporarily render a safety device incapable of proper or effective action or to materially impair its function if this action is taken as provided for in paragraph (b) or (c) of this...

  3. Safety analysis of Epzicom® (lamivudine/abacavir sulfate) in post-marketing surveillance in Japan†

    PubMed Central

    Kurita, Tomoko; Kitaichi, Tomomi; Nagao, Takako; Miura, Toshiyuki; Kitazono, Yoshifumi

    2014-01-01

    Purpose To obtain safety and effectiveness data on a combined anti-HIV drug, Epzicom (abacavir 600 mg/lamivudine 300 mg), a post-marketing surveillance on Epzicom that was required by the Japanese regulatory authority was conducted between January 2005 and December 2010. Methods A joint survey (HIV-related drug [HRD] survey) has been conducted involving manufacturers of drugs for treatment of HIV infection in Japan. Safety and effectiveness data from total 624 cases (1107.3 person-years) registered to the HRD surveys and received Epzicom were obtained. Adverse drug reactions (ADRs) were defined as adverse events (AE) of which association with Epzicom could not be ‘ruled out’. Results It was found that the incidence of ADR was 32.4% (202/624 cases) on the case basis. In addition, the frequently reported ADR included hyperlipidaemia (59 cases), hypertriglyceridaemia (21 cases), blood bilirubin increased (19 cases), gamma-glutamyltransferase increase (14 cases), blood triglyceride increase (14 cases) and rash (14 cases). Serious AEs were seen in 19 patients (30 events), including one death (no evident association with Epzicom). There were four cases (0.6%) of survey-defined ‘hypersensitivity’, and the incidence was 0.9% (4/445) among abacavir naïve patients; none of which was reported as serious. No case of myocardial infarction was reported. One pregnant case who delivered a normal baby by caesarean section was reported to have experienced aggravation of anaemia and nausea. Conclusions The post-marketing surveillance indicated that the incidence of both ischaemic heart disease and hypersensitivity associated with Epzicom was considerably low, suggesting that this drug can be safely used in the Japanese population. PMID:24590575

  4. Alma Mater and an American Dream: "The Mountains" (1859) Dustin Griffin Posted with permission of author. Alma Mater and an American Dream: "The Mountains" (1859) Dustin Griffin Posted with permission of author.

    E-print Network

    Aalberts, Daniel P.

    Alma Mater and an American Dream: "The Mountains" (1859) © Dustin Griffin Posted with permission of author. #12;Alma Mater and an American Dream: "The Mountains" (1859) © Dustin Griffin Posted with permission of author. #12;Alma Mater and an American Dream: "The Mountains" (1859) © Dustin Griffin Posted

  5. Procedure-Authoring Tool Improves Safety on Oil Rigs

    NASA Technical Reports Server (NTRS)

    2014-01-01

    Dark, cold, and dangerous environments are plentiful in space and on Earth. To ensure safe operations in difficult surroundings, NASA relies heavily on procedures written well ahead of time. Houston-based TRACLabs Inc. worked with Ames Research Center through the SBIR program to create an electronic procedure authoring tool, now used by NASA and companies in the oil and gas industry.

  6. Prague, Tourism and the Post-industrial City Co-authors

    E-print Network

    Illinois at Chicago, University of

    ). This present article takes a broader more contextual view of the role of tourism in the development of tourism in the transition. Third, where tourism is discussed, it is usually, as an urban developmentPrague, Tourism and the Post-industrial City Co-authors: Lily M. Hoffman and Jiri Musil Great

  7. Author's personal copy Optimal conditions for egg storage, incubation and post-hatching

    E-print Network

    Canberra, University of

    Author's personal copy Optimal conditions for egg storage, incubation and post-hatching growth August 2006; received in revised form 9 March 2007; accepted 9 March 2007 Abstract Incubation of northern until there are sufficient numbers to incubate as batches. Eggs that are not inundated or inundated

  8. Air Quality: Roles, Responsibilities, and Authorities Matrix Department: Chemical and General Safety

    E-print Network

    Wechsler, Risa H.

    Air Quality: Roles, Responsibilities, and Authorities Matrix Department: Chemical and General Safety Program: Air Quality Owner: Program Manager Authority: ES&H Manual, Chapter 30, Air Quality1 The following tables summarize major air quality program requirements and map them to the appropriate

  9. The Environmental Agency's Assessment of the Post-Closure Safety Case for the BNFL DRIGG Low Level Radioactive Waste Disposal Facility

    SciTech Connect

    Streatfield, I. J.; Duerden, S. L.; Yearsley, R. A.

    2002-02-26

    The Environment Agency is responsible, in England and Wales, for authorization of radioactive waste disposal under the Radioactive Substances Act 1993. British Nuclear Fuels plc (BNFL) is currently authorized by the Environment Agency to dispose of solid low level radioactive waste at its site at Drigg, near Sellafield, NW England. As part of a planned review of this authorization, the Environment Agency is currently undertaking an assessment of BNFL's Post-Closure Safety Case Development Programme for the Drigg disposal facility. This paper presents an outline of the review methodology developed and implemented by the Environment Agency specifically for the planned review of BNFL's Post-Closure Safety Case. The paper also provides an overview of the Environment Agency's progress in its on-going assessment programme.

  10. The Food and Drug Administration's Post-Licensure Rapid Immunization Safety Monitoring program: strengthening the federal vaccine safety enterprise.

    PubMed

    Nguyen, Michael; Ball, Robert; Midthun, Karen; Lieu, Tracy A

    2012-01-01

    In 2009, the Department of Health and Human Services created the new Post-Licensure Rapid Immunization Safety Monitoring (PRISM) program, which used data from national health insurance plans and immunization registries to monitor the safety of the H1N1 influenza vaccine. PRISM has now been integrated into the FDA's Mini-Sentinel pilot program. It strengthens the federal vaccine safety enterprise in two important ways. First, PRISM monitors the largest US general population cohort designated for active surveillance of vaccine safety. Second, PRISM links data from health plans with data from state and city immunization registries, which were a crucial source of exposure data in the H1N1 vaccine evaluation. The Mini-Sentinel data that support PRISM are updated quarterly, and PRISM can conduct medical record review for validation of computerized data. The FDA has structured PRISM as a program that includes specific vaccine evaluations, development of an operational framework to guide the design of vaccine safety evaluations, and development of new statistical methods. A human papillomavirus vaccine, Gardasil, and two rotavirus vaccines, RotaTeq and Rotarix, have been chosen for surveillance in the current cycle because their evaluations would benefit most from PRISM's large cohort size. The PRISM program creates important opportunities by offering a robust, responsive new surveillance program with features complementary to existing systems. Methodological and logistical lessons can be shared among PRISM and other surveillance systems, offering potential synergies. FDA and PRISM will work to maximize the program's unique strengths and contributions to a unified federal vaccine safety enterprise. PMID:22262619

  11. Scientific Method and the Regulation of Health and Nutritional Claims by the European Food Safety Authority

    ERIC Educational Resources Information Center

    Hoad, Darren

    2011-01-01

    The protection of European consumers from the false or misleading scientific and nutritional claims of food manufacturers took a step forward with the recent opinions of the European Food Safety Authority (EFSA). As a risk assessment agency, the EFSA recently assessed and rejected a vast number of food claim forcing the withdrawal of many claims…

  12. JORDI SERRATOSA, PH.D. European Food Safety Authority Liaison Officer

    E-print Network

    Minnesota, University of

    JORDI SERRATOSA, PH.D. European Food Safety Authority Liaison Officer U.S. Food and Drug Administration Jordi Serratosa has a Ph.D. in probiotics used as feed additives from Hanover University, Germany; a bachelor's degree in hygiene, science and food technology from Universidad Complutense of Madrid, Spain

  13. Efficacy and Safety of the Angioseal Vascular Closure Device Post Antegrade Puncture

    SciTech Connect

    Looby, S.; Keeling, A. N.; McErlean, A.; Given, M. F.; Geoghegan, T.; Lee, M. J. [Beaumont Hospital, Department of Radiology (Ireland)], E-mail: mlee@rcsi.ie

    2008-05-15

    In this study, the efficacy and safety of the Angioseal vascular closure device post antegrade puncture of the common femoral artery (CFA) for lower limb vascular interventional procedures are evaluated. A retrospective analysis of the medical records of 60 consecutive patients who were referred for interventional procedures in the superficial femoral artery (SFA) or popliteal artery (popl. art.) was performed. Antegrade puncture was successfully performed in 58 of 60 patients (96.6%). Indications included right SFA angioplasty (n = 35), left SFA angioplasty (n = 17), right popl. art. angioplasty (n = 5), and left popl. art. angioplasty (n = 1). Hemostasis was achieved by, on an intention-to-treat basis, the Angioseal vascular closure device in 46 patients and manual compression in 12 patients. Manual compression was used instead of Angioseal because of severe calcified arterial wall plaques (n = 7), failed deployment of the Angioseal (n = 4), and left SFA dissection (n = 1). There were no major recorded complications in the Angioseal group despite the use of antiplatelet or anticoagulant medications. Twenty-three (50%) of the patients in the Angioseal group were discharged within 24 h. Thirty-seven of the 46 patients who received an Angioseal device had undergone a previous ipsilateral CFA puncture (time range, 2 days to 56 months; mean, 6.2 months). Nine of these patients had undergone ipsilateral Angioseal deployment in the previous 3 months. We conclude that the Angioseal vascular closure device is a safe and efficient means of achieving hemostasis post antegrade puncture.

  14. Health and safety inspection of hairdressing and nail salons by local authority environmental health practitioners.

    PubMed

    Harris-Roberts, Joanne; Bowen, Jo; Sumner, Jade; Fishwick, David

    2013-01-01

    The objective of the study described in this article was to provide environmental health practitioners (EHPs) with an evaluation of the levels of understanding of, and compliance with, health and safety legislation in hairdressing and nail salons. EHPs carried out a series of inspections of 205 salons in a large British city, consisting of a site assessment and an assessment of employee knowledge of relevant regulations, including those relating to control of exposure to hazardous substances. Two-fifths of senior salon employees understood Control of Substances Hazardous to Health (COSHH) assessments and could provide evidence of their completion. Most employees had been trained and made aware of the health hazards associated with carrying out their work and took suitable precautions to protect themselves and their clients. The results suggest that senior employees within the salons sampled, have knowledge of the risks to health and have been taking measures to control these risks. Initiatives such as the Health and Safety Executive's (in collaboration with local authorities and the hairdressing industry) "Bad Hand Day?" campaign and sector-specific COSHH essentials guidance help raise awareness levels and aim to support good control practice in salons. PMID:23397656

  15. Recent European Food Safety Authority toxicological evaluations of major phthalates used in food contact materials.

    PubMed

    Lhuguenot, Jean-Claude

    2009-08-01

    During the 1980s and 1990s, and at the EU level, the Scientific Committee for Food evaluated a number of phthalates that were being used, or were requested for use, as additives in plastics. At this time, peroxisome proliferation was considered as the pivotal effect on which toxicological evaluation of these chemicals was based. At the end of 1990s, a general consensus has been agreed that rodents are highly sensitive to the phenomenon of peroxisome proliferation and that this particular effect should not be used for human risk assessment. Consequently in 2004, it was requested from the newly created European Food Safety Authority to perform a new evaluation of the mainly used phthalates on the basis of existing data. This paper summarizes evaluations of butylbenzylphthalate, dibutylphthalate, diethylhexylphthalate. PMID:19603396

  16. SheetEnvironment, Health and Safety Information for the Berkeley Campus Please post or circulate

    E-print Network

    Cohen, Ronald C.

    ) 642-3073 Created 1/22/08 Basic requirements of the UCB Laser Safety Program Laser Safety Program The UC Berkeley Non-Ionizing Radiation Safety Committee (NIRSC) is responsible for making laser safety Berkeley Laser Safety Program is based on the ANSI Z136.1 (2000) Standard for the Safe Use of Lasers (as

  17. 77 FR 28451 - Unsatisfactory Safety Rating; Revocation of Operating Authority Registration; Technical Amendments

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-14

    ...final rule raises no environmental justice issues nor is there any collective environmental impact resulting from...rule does not pose an environmental risk to health or safety...satisfactory safety rating is based on the...

  18. 41 CFR 302-9.209 - Under what conditions may my agency authorize me to transport from my post of duty a replacement...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...may my agency authorize me to transport from my post of duty a replacement POV purchased at that post of duty? 302-9.209 Section 302-9...VEHICLE Return Transportation of a POV From a Post of Duty § 302-9.209 Under what...

  19. 41 CFR 302-9.204 - What is the “authorized point of origin” when I transport my POV from my post of duty?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...originâ when I transport my POV from my post of duty? 302-9.204 Section 302-9... Return Transportation of a POV From a Post of Duty § 302-9.204 What is the...origin” when I transport my POV from my post of duty? The “authorized point of...

  20. Authors

    Cancer.gov

    Authors Laura Boyle, MPH, CHES Consultant, National Cancer Institute Megan Homer, MA Emerging Leader, Department of Health and Human Services Acknowledgements Lenora Johnson, MPH, National Cancer Institute; Jon Kerner, PhD, National Cancer Institute;

  1. 41 CFR 302-9.203 - Is there any circumstance under which I may be authorized to transport my POV from a post of duty...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...authorized to transport my POV from a post of duty before completing my service agreement? ...Contracts and Property Management Federal Travel Regulation...authorized to transport my POV from a post of duty...transportation is based on changed conditions, you are...

  2. Approaches in the risk assessment of genetically modified foods by the Hellenic Food Safety Authority.

    PubMed

    Varzakas, Theodoros H; Chryssochoidis, G; Argyropoulos, D

    2007-04-01

    Risk analysis has become important to assess conditions and take decisions on control procedures. In this context it is considered a prerequisite in the evaluation of GM food. Many consumers worldwide worry that food derived from genetically modified organisms (GMOs) may be unhealthy and hence regulations on GMO authorisations and labelling have become more stringent. Nowadays there is a higher demand for non-GM products and these products could be differentiated from GM products using the identity preservation system (IP) that could apply throughout the grain processing system. IP is the creation of a transparent communication system that encompasses HACCP, traceability and related systems in the supply chain. This process guarantees that certain characteristics of the lots of food (non-GM origin) are maintained "from farm to fork". This article examines the steps taken by the Hellenic Food Safety Authority to examine the presence of GMOs in foods. The whole integrated European legislation framework currently in place still needs to be implemented in Greece. Penalties should be enforced to those who import, process GMOs without special licence and do not label those products. Similar penalties should be enforced to those companies that issue false certificates beyond the liabilities taken by the food enterprises for farmers' compensation. We argue that Greece has no serious reasons to choose the use of GMOs due to the fact that the structural and pedologic characteristics of the Greek agriculture favour the biological and integrated cultivation more. Greece is not in favour of the politics behind coexistence of conventional and GM plants and objects to the use of GMOs in the food and the environment because the processor has a big burden in terms of money, time and will suffer a great deal in order to prove that their products are GMO free or that any contamination is adventitious or technically unavoidable. Moreover, Greece owns a large variety of genetic material that should try to protect from patenting and commercialisation. Finally, we should be aware of the requirements of movement of GMOs within borders, i.e. GMOs grown or used in other countries but which are not intended to cross into Greece, since Greece is very close to countries that are non-EU. This is where the development of a new, integrated, trustworthy and transparent food quality control system will help to satisfy the societal demands for safe and quality products. On the other hand, Greece should not be isolated from any recent scientific technological development and should assess the possible advantages for some cultivation using a case by case approach. Finally, the safety assessment of GM foods and feed has been discussed according to the risk assessment methodology applied by EFSA. PMID:17275157

  3. A Comprehensive Framework for Post-market Electrical Safety Testing and Performance Assessment of Medical Equipment in Healthcare Facilities

    Microsoft Academic Search

    J. C. Langanke Pedroso; S. J. Calil

    \\u000a This paper presents a comprehensive framework for electrical safety testing and performance assessment of medical equipment,\\u000a to be conducted as routine tests in health care facilities by clinical engineering personnel. The rationale for it is that\\u000a very little has been published in terms of protocols, guidelines, policies and\\/or technical standards for post market evaluation\\u000a of medical equipment. Whilst type tests

  4. Safety evaluation of phytosterol-esters. Part 9: Results of a European post-launch monitoring programme

    Microsoft Academic Search

    L. J. Lea; P. A. Hepburn

    2006-01-01

    Phytosterol-esters were developed by Unilever as a cholesterol lowering novel food ingredient for use initially in vegetable oil spreads. In addition to an extensive package of safety studies and clinical studies a programme of post-launch monitoring (PLM) was developed. PLM was used to address the following questions: (a) Is the product use as predicted\\/recommended? (b) Are the known effects as

  5. 10 CFR 35.57 - Training for experienced Radiation Safety Officer, teletherapy or medical physicist, authorized...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...or medical physicist, authorized medical physicist, authorized user, nuclear pharmacist, and authorized nuclear pharmacist. 35.57 Section 35.57 Energy NUCLEAR REGULATORY COMMISSION MEDICAL USE OF BYPRODUCT MATERIAL General...

  6. 10 CFR 35.57 - Training for experienced Radiation Safety Officer, teletherapy or medical physicist, authorized...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...or medical physicist, authorized medical physicist, authorized user, nuclear pharmacist, and authorized nuclear pharmacist. 35.57 Section 35.57 Energy NUCLEAR REGULATORY COMMISSION MEDICAL USE OF BYPRODUCT MATERIAL General...

  7. 10 CFR 35.57 - Training for experienced Radiation Safety Officer, teletherapy or medical physicist, authorized...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...or medical physicist, authorized medical physicist, authorized user, nuclear pharmacist, and authorized nuclear pharmacist. 35.57 Section 35.57 Energy NUCLEAR REGULATORY COMMISSION MEDICAL USE OF BYPRODUCT MATERIAL General...

  8. 10 CFR 35.57 - Training for experienced Radiation Safety Officer, teletherapy or medical physicist, authorized...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...or medical physicist, authorized medical physicist, authorized user, nuclear pharmacist, and authorized nuclear pharmacist. 35.57 Section 35.57 Energy NUCLEAR REGULATORY COMMISSION MEDICAL USE OF BYPRODUCT MATERIAL General...

  9. 10 CFR 35.57 - Training for experienced Radiation Safety Officer, teletherapy or medical physicist, authorized...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...or medical physicist, authorized medical physicist, authorized user, nuclear pharmacist, and authorized nuclear pharmacist. 35.57 Section 35.57 Energy NUCLEAR REGULATORY COMMISSION MEDICAL USE OF BYPRODUCT MATERIAL General...

  10. Post

    NSDL National Science Digital Library

    What is this thing, this Post? It is a platform for critical response, and a constantly evolving space for sharing research and testing ideas. Post was created by staff members at the Museum of Modern Art in New York to allow people to share texts, images, and videos in the hope that "multiple narratives of art's histories emerge." Along the top section of the homepage, users will find areas like Contents, Themes, Latest, and Participants. Browsing the Themes area. visitors can look over posts on the Fluxus network that existed between New York and Tokyo in the 1960s or the intriguing post examining how archival artworks form a key part of museum culture. Moving on, the Latest area includes a few gems, including mediations on the spatial poems of Shiomi Mieko and a reflection on the term "Latin American Conceptualism." As another consideration, passers-by are also encouraged to leave their own thoughts on each of these intriguing contemplations of what "modern" art means.

  11. Attitudes and beliefs on the establishment of a national food safety authority in Cyprus. A population-based survey.

    PubMed

    Hadjigeorgiou, Andreas; Talias, Michael A; Soteriades, Elpidoforos S; Philalithis, Anastasios; Psaroulaki, Anna; Gikas, Achilleas; Tselentis, Yiannis

    2014-04-01

    Cyprus does not have a National Food Safety Authority (NFSA), but a multi-level, fragmented system with responsibilities divided among different ministries and governmental agencies, frequently impeding efforts to effectively manage food risks by duplication and overlapping of responsibilities. A population-based survey was carried out to determine the beliefs and attitudes of interested parties concerning the establishment of a NFSA in Cyprus. Information was collected using a random stratified sampling design and a structured questionnaire. A total of 868 questionnaires were collected (704 from regular consumers, 154 from food businesses' representatives, and 10 from public services' directors or acting head officers). About 11% of food businesses' representatives and 45% of consumers reported that they did not know which public authorities are responsible for food control. Moreover, 2 out of 10 (17%) of responders from public agencies, 70% from food businesses and 91% from consumers, although not aware of ongoing efforts to establish a food safety authority in Cyprus (currently under consideration), were supportive of the idea [8 out of 10 (83%) of responders from public services, 93% from food businesses, and 89% of consumers]. Finally, 7 out of 10 (67%) from the public agencies and 84% of representatives from food businesses agreed with the separation of risk assessment from risk management activities. Public opinion in Cyprus as well as public agencies and food businesses' representatives support the establishment of a single independent national food safety authority in Cyprus based on the European paradigm including the division of risk activities. PMID:24378621

  12. Back to the Future: Leadership, Tradition, and Authority in a Post-Critical Age

    ERIC Educational Resources Information Center

    Hawkins, Andrew

    2010-01-01

    Both modern and postmodern approaches to knowledge view tradition and authority with suspicion, even contempt, though each approach does so in different ways. Our profession vacillates between those epistemological orientations, struggling to find direction and meaning. Leadership, in particular, is in a quandary; what does leadership look like in…

  13. Further Education outside the Jurisdiction of Local Education Authorities in Post-War England

    ERIC Educational Resources Information Center

    Simmons, Robin

    2014-01-01

    This article revisits the three decades following the end of World War Two--a time when, following the 1944 Education Act, local education authorities (LEAs) were the key agencies responsible for running the education system across England. For the first time, there was a statutory requirement for LEAs to secure adequate facilities for further…

  14. 41 CFR 302-9.101 - In what situations may my agency authorize transportation of a POV to my post of duty?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...In what situations may my agency authorize transportation of a POV to my post of duty? 302-9...Contracts and Property Management Federal Travel Regulation...In what situations may my agency authorize transportation...prior authorization have changed to warrant such...

  15. Index to Nuclear Safety: a technical progress review by chronology, permuted title, and author, Volume 18 (1) through Volume 22 (6)

    SciTech Connect

    Cottrell, W.B.; Passiakos, M.

    1982-06-01

    This index to Nuclear Safety covers articles published in Nuclear Safety, Volume 18, Number 1 (January-February 1977) through Volume 22, Number 6 (November-December 1981). The index is divided into three section: a chronological list of articles (including abstracts), a permuted-title (KWIC) index, and an author index. Nuclear Safety, a bimonthly technical progress review prepared by the Nuclear Safety Information Center, covers all safety aspects of nuclear power reactors and associated facilities. Over 300 technical articles published in Nuclear Safety in the last 5 years are listed in this index.

  16. State Regulatory Authority (SRA) Coordination of Safety, Security, and Safeguards of Nuclear Facilities: A Framework for Analysis

    SciTech Connect

    Mladineo, Stephen V.; Frazar, Sarah L.; Kurzrok, Andrew J.; Martikka, Elina; Hack, Tapani; Wiander, Timo

    2013-05-30

    This paper will explore the development of a framework for conducting an assessment of safety-security-safeguards integration within a State. The goal is to examine State regulatory structures to identify conflicts and gaps that hinder management of the three disciplines at nuclear facilities. Such an analysis could be performed by a State Regulatory Authority (SRA) to provide a self-assessment or as part of technical cooperation with either a newcomer State, or to a State with a fully developed SRA.

  17. Institutional Response to Ohio's Campus Safety Initiatives: A Post-Virginia Tech Analysis

    ERIC Educational Resources Information Center

    Jackson, Natalie Jo

    2009-01-01

    The purpose of this study was to examine how institutions of higher education were responding to unprecedented state involvement in campus safety planning and policymaking in the aftermath of the Virginia Tech tragedy. Focused on Ohio, a state in which a state-level task force was convened and charged to promulgate campus safety recommendations…

  18. Immediate post-partum initiation of intrauterine contraception and implants: a review of the safety and guidelines for use.

    PubMed

    Mwalwanda, Carolyn S; Black, Kirsten I

    2013-08-01

    Women are particularly susceptible to unintended pregnancies in the first year after birth, with 10-44% of pregnancies being unintended. In many settings, post-partum birth control is initiated at the six-week post-partum visit but most women are sexually active by this time, and ovulation can occur as early as day 28. There are many potential advantages of initiating intrauterine contraception (IUC) and implants use in the immediate post-partum period, including their high efficacy and reversibility which rivals sterilisation as well as ease of access to providers trained in their insertion. This review aims to describe the benefits and risks of use of IUC and implants in the immediate post-partum period. It discusses the maternal and infant health safety issues of early initiation of the progestogen containing methods and provides a critical review of existing international guidelines. Overall low rates of adverse effects such as pain, bleeding, infection and perforation, are documented to occur in all studies regardless of the timing or route of IUC insertion. Expulsion rates are significantly higher immediately after vaginal delivery compared to interval insertions, but are no higher after insertion at caesarean section. Post-partum implants appear to have the same side effects as interval insertions, and to date, no adverse impact on breast milk or infant growth has been demonstrated. Most international evidence-based guidelines support the initiation of IUC and progestogen containing contraceptive methods in the immediate post-partum period as they regard the advantages of provision at this time to outweigh the risks. PMID:23635040

  19. Antiterrorism design and public safety : reconciling CPTED with the post-9/11 city

    E-print Network

    Rothrock, Sara E. (Sara Elizabeth)

    2010-01-01

    Urban downtowns have changed since September 1 1, 2001, sprouting bollards, planters, and barriers installed on the pretense of improved safety and security. While these interventions protect buildings from vehicle bombs, ...

  20. EHS DSP Authorization Request Form 2012-001 Safety & Risk Management

    E-print Network

    , 1985) requires all motorists to carry evidence of current automobile liability insurance and proof of liability insurance in my possession, all persons in the vehicle will wear safety belts and the vehicle shall always be: 1. Covered by liability insurance for the minimum amount prescribed by State Law

  1. FDA's expanding postmarket authority to monitor and publicize food and consumer health product risks: the need for procedural safeguards to reduce "transparency" policy harms in the post-9/11 regulatory environment.

    PubMed

    Roller, Sarah Taylor; Pippins, Raqiyyah R; Ngai, Jennifer W

    2009-01-01

    This article provides a summary of the expansion of FDA's discretionary authority in the post-9/11 period, particularly with respect to FDA's authority to monitor and publicize potential health risks linked to food, dietary supplements, nonprescription drugs, and other consumer health products. In addition, this article evaluates the need for FDA to establish procedural safeguards to reduce the significant risks of unintended and undue harm to people and regulated companies that can result from adverse publicity in the more "transparent" post 9/11 FDA regulatory environment. Specifically, Part I summarizes the amendments to the FDCA enacted during the post-9/11 period that have expanded FDA's postmarket authority to monitor, evaluate, and publicize potential health risks linked to food, dietary supplements, nonprescription drugs and other consumer health products marketed in the United States, in conjunction with FDA's Sentinel Initiative, Reportable Food Registry, and other adverse event reporting requirements. Part II discusses the convergence of FDA's expanded postmarket authority to publicize product-related risks with President Obama's transparency initiative aimed at fostering "open government" through increased public access to government information. In addition, Part II considers the nature of the procedural safeguards needed in the post-9/11 FDA regulatory environment, in view of FDA's historical record and illustrative cases that help expose how adverse "transparency" surrounding FDA warning letters, recalls and safety alerts concerning products in the marketplace can have undue and unintended prejudicial and harmful effects for the people and companies that are legally responsible for such products. Finally, based on these analysis, this article concludes with some observations concerning the nature of the procedural safeguards needed to reduce the significant risks of "transparency" policy harms in the pos-9/11 regulatory environment. PMID:19999646

  2. Incentivizing Primary Care Providers to Innovate: Building Medical Homes in the Post-Katrina New Orleans Safety Net

    PubMed Central

    Rittenhouse, Diane R; Schmidt, Laura A; Wu, Kevin J; Wiley, James

    2014-01-01

    ObjectiveTo evaluate safety-net clinics’ responses to a novel community-wide Patient-Centered Medical Home (PCMH) financial incentive program in post-Katrina New Orleans. Data Sources/Study SettingBetween June 2008 and June 2010, we studied 50 primary care clinics in New Orleans receiving federal funds to expand services and improve care delivery. Study DesignMultiwave, longitudinal, observational study of a local safety-net primary care system. Data CollectionClinic-level data from a semiannual survey of clinic leaders (89.3 percent response rate), augmented by administrative records. Principal FindingsOverall, 62 percent of the clinics responded to financial incentives by achieving PCMH recognition from the National Committee on Quality Assurance (NCQA). Higher patient volume, higher baseline PCMH scores, and type of ownership were significant predictors of achieving NCQA recognition. The steepest increase in adoption of PCMH processes occurred among clinics achieving the highest, Level 3, NCQA recognition. Following NCQA recognition, 88.9 percent stabilized or increased their use of PCMH processes, although several specific PCMH processes had very low rates of adoption overall. ConclusionsFindings demonstrate that widespread PCMH implementation is possible in a safety-net environment when external financial incentives are aligned with the goal of practice innovation. PMID:23800148

  3. Ethical Considerations of Family Secret Disclosure and Post-Session Safety Management.

    ERIC Educational Resources Information Center

    Fall, Kevin A.; Lyons, Christy

    2003-01-01

    The literature largely ignores the ethical issues surrounding in-session disclosure of family secrets and the concomitant liability of the family therapist for the post-session well-being of the system's members. This article explores types of family secrets, provides a case example of in-session disclosure, and presents ethical considerations and…

  4. 78 FR 28897 - Tennessee Valley Authority; Establishment of Atomic Safety and Licensing Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-16

    ...Authority to renew for twenty years its operating licenses for Sequoyah Nuclear Plant, Units 1 and 2, which are located in Soddy-Daisy, Tennessee. The current Unit 1 and Unit 2 operating licenses expire, respectively, on September 17, 2020 and...

  5. 77 FR 71454 - Notice of Atomic Safety And Licensing Board Reconstitution, Tennessee Valley Authority (Watts Bar...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-30

    ...Licensing Board Reconstitution, Tennessee Valley Authority (Watts Bar, Unit 2) Pursuant to 10 CFR 2.313(c) and 2.321(b...and Licensing Board (Board) in the above-captioned Watts Bar, Unit 2 operating license application proceeding is hereby...

  6. Safety and tolerability of bivalent HPV vaccine: an Italian post-licensure study.

    PubMed

    Gasparini, Roberto; Bonanni, Paolo; Levi, Miriam; Bechini, Angela; Boccalini, Sara; Tiscione, Emilia; Amicizia, Daniela; Lai, Piero Luigi; Sulaj, Klodiana; Patria, Antonio Giuseppe; Panatto, Donatella

    2011-01-01

    One of the most important scientific discoveries of the last century was that persistent infection by some types of HPV is a precondition for the development of cervical cancer. The oncogenic types of HPV are also associated with other tumours (vaginal, vulvar and anal carcinomas, tumours of the head and neck, urethra and penis). Two preventive vaccines are currently available (Cervarix and Gardasil). Both have shown very good efficacy, safety and tolerability profiles. Nonetheless, extensive vaccination requires long-term monitoring of safety and tolerability. The aim of our study was to evaluate the safety and tolerability of the bivalent vaccine Cervarix in Italy. Every participant in the study completed a questionnaire after each dose of vaccine received, with a view to recording adverse events during the first 7 days after vaccination. We registered local (pain, redness, swelling) and systemic symptoms (fever, headache, myalgia, fatigue, arthralgia, itching, gastrointestinal disorders, rash and urticaria). A total of 4,643 subjects were recruited. In all, 7,107 questionnaires were collected: 3,064 after the first dose, 2,367 after the second and 1,676 after the third. No serious adverse events were observed. The most frequent local symptom was pain at the injection site, while fatigue, headache and myalgia were the most common systemic reactions. Pain was reported more frequently after the first dose than after the others, while all the other local and general symptoms were reported most frequently after the third dose. Almost all of the local and general reactions proved to be of negligible intensity and duration and required no medical intervention. Our results show better tolerability of the vaccine in comparison with the data from some controlled clinical studies and from other surveillance programmes conducted internationally. That tolerability proved to be better than in clinical studies could be explained by the absence of the typical apprehension felt by subjects involved in clinical experimentation. PMID:21266842

  7. Safety evaluation of phytosterol-esters. Part 9: Results of a European post-launch monitoring programme.

    PubMed

    Lea, L J; Hepburn, P A

    2006-08-01

    Phytosterol-esters were developed by Unilever as a cholesterol lowering novel food ingredient for use initially in vegetable oil spreads. In addition to an extensive package of safety studies and clinical studies a programme of post-launch monitoring (PLM) was developed. PLM was used to address the following questions: (a) Is the product use as predicted/recommended? (b) Are the known effects as predicted? (c) Does the product cause unexpected health effects? The overall conclusions from the PLM programme were: the product is being bought by the target population but intakes are less than the original assumptions made in the risk assessment; long-term use of phytosterol-ester enriched spreads results in a reduction in the serum levels of the most lipophilic carotenoids but at current levels of intake this is unlikely to result in reductions in carotenoids that are of biological significance; evaluation of health related consumer complaints have not indicated any unexpected health effects associated with the use of the product in the marketplace. As part of the European approval under Regulation (EC) No. 258/97 on Novel Foods and Food Ingredients the results of the PLM programme had to be submitted to the European Commission (EC) and reviewed by the Scientific Committee on Food (SCF). They concluded that the study provided valuable information, which complemented the pre-market safety evaluation studies, and that the EC mandatory requirement had been met. PMID:16542769

  8. New modes of regulation for health and safety: post-enlargement policy perspectives for the European Union.

    PubMed

    Woolfson, Charles

    2006-01-01

    The recent joining of ten new member states to the European Union, eight of which are former communist countries, has reopened inherent tensions in current European Union (EU) policy-making on safety and health in the workplace. These spring from seemingly incompatible objectives; the need to ensure broad EU member state compliance with regulation, around agreed minimum standards through active regulatory enforcement, and the promotion of "softer" voluntary initiatives in the management of workplace risks and hazards in order to create "a culture of prevention." The present EU strategy which ends in 2006, seeks to secure a balance between both sets of objectives. However, with respect to the post-communist new member states of Central and Eastern Europe, the appropriateness of the current strategy is doubtful. This article therefore focuses on the implications of the expansion of the European Union in May 2004 in the context of the elaboration of the new "soft law" modes of regulatory governance at the EU level. In turn, this provokes the question: will the "new" European policy for occupational health and safety from 2007 onwards, be "new," or simply more of the same? If the latter, it is suggested that the future for working environment standards in Europe as a whole may be significantly compromised. PMID:16943136

  9. SHSD Manager Safety Engineering Group Manager

    E-print Network

    . Shepherd: Explosives Safety, Facility Authorization Basis, Nuclear Safety R. Travis: Readiness Evaluations Safety, Machine Shop Safety, Tier I Program, Traffic Safety S. Moss: Nuclear Criticality Safety G

  10. PAT-1 safety analysis report addendum author responses to request for additional information.

    SciTech Connect

    Weiner, Ruth F.; Schmale, David T.; Kalan, Robert J.; Akin, Lili A.; Miller, David Russell; Knorovsky, Gerald Albert; Yoshimura, Richard Hiroyuki; Lopez, Carlos; Harding, David Cameron; Jones, Perry L.; Morrow, Charles W.

    2010-09-01

    The Plutonium Air Transportable Package, Model PAT-1, is certified under Title 10, Code of Federal Regulations Part 71 by the U.S. Nuclear Regulatory Commission (NRC) per Certificate of Compliance (CoC) USA/0361B(U)F-96 (currently Revision 9). The National Nuclear Security Administration (NNSA) submitted SAND Report SAND2009-5822 to NRC that documented the incorporation of plutonium (Pu) metal as a new payload for the PAT-1 package. NRC responded with a Request for Additional Information (RAI), identifying information needed in connection with its review of the application. The purpose of this SAND report is to provide the authors responses to each RAI. SAND Report SAND2010-6106 containing the proposed changes to the Addendum is provided separately.

  11. Effectiveness and Safety of Arnica montana in Post-Surgical Setting, Pain and Inflammation.

    PubMed

    Iannitti, Tommaso; Morales-Medina, Julio César; Bellavite, Paolo; Rottigni, Valentina; Palmieri, Beniamino

    2014-09-17

    Arnica montana has been widely used as a homeopathic remedy for the treatment of several inflammatory conditions in pain management and postoperative settings. This review gives an overview of the therapeutic use of Arnica montana in the above-mentioned fields also focusing on its mechanisms of action learned from animal models and in vitro studies. Arnica montana is more effective than placebo when used for the treatment of several conditions including post-traumatic and postoperative pain, edema, and ecchymosis. However, its dosages and preparations used have produced substantial differences in the clinical outcome. Cumulative evidence suggests that Arnica montana may represent a valid alternative to non-steroidal anti-inflammatory drugs, at least when treating some specific conditions. PMID:25171757

  12. Safety.

    ERIC Educational Resources Information Center

    Education in Science, 1996

    1996-01-01

    Discusses safety issues in science, including: allergic reactions to peanuts used in experiments; explosions in lead/acid batteries; and inspection of pressure vessels, such as pressure cookers or model steam engines. (MKR)

  13. ISRAEL JOURNAL OF ZOOLOGY, Vol. 48, 2002, pp. 351357 *Author to whom correspondence should be addressed. E-mail: yomtov@post.tau.ac.il

    E-print Network

    Yom-Tov, Yoram

    ISRAEL JOURNAL OF ZOOLOGY, Vol. 48, 2002, pp. 351­357 *Author to whom correspondence should be addressed. E-mail: yomtov@post.tau.ac.il Accepted March 2003. GLOBAL WARMING AND RECENT CHANGES IN ISRAEL'S AVIFAUNA OHAD HATZOFEa AND YORAM YOM-TOVb, * a Division of Science and Conservation, Israel Nature

  14. Efficacy and Safety of Miltefosine in Treatment of Post-Kala-Azar Dermal Leishmaniasis

    PubMed Central

    Singh, Anup; Chakravarty, Jaya; Rai, Madhukar

    2015-01-01

    Background. Long regimens for the treatment of post-kala-azar dermal leishmaniasis (PKDL) result in noncompliance. A safe, effective, and acceptable regimen for the treatment of PKDL is still to be developed. Miltefosine has been found to be effective in the treatment of Visceral Leishmaniasis (VL). Hence, its efficacy was tested in patients of PKDL. Methods. In this exploratory study, 33 patients with PKDL aged 10 years and above were administered miltefosine (50?mg for those weighing <25?kg or 100?mg in divided doses for those ?25?kg and 2.5?mg per kg for children) for 12 weeks and followed up for one year to find out the efficacy. Results. Out of 33 patients, 3 patients withdrew consent. Treatment was stopped due to adverse effect in 1 patient. 28 (96.6%) got cured with complete disappearance of lesion while 1 patient (3.4%) failed treatment by protocol analysis. Conclusion. Miltefosine was found to be effective and safe in the treatment of PKDL. PMID:25685839

  15. Effect of grain storage and processing on chlorpyrifos-methyl and pirimiphos-methyl residues in post-harvest-treated wheat with regard to baby food safety requirements

    Microsoft Academic Search

    A. Balinova; R. Mladenova; D. Obretenchev

    2006-01-01

    A study was undertaken to assess the effects of storage intervals and of milling procedures on the dissipation of chlorpyrifos-methyl and pirimiphos-methyl residues in post-harvest-treated wheat grain and to obtain scientific data on the compliance of the processed products with safety requirements concerning baby foods. The insecticide formulations were applied on stored wheat at recommended rates (20?ml?t). The initial concentration

  16. Study on the effect of grain storage and processing on deltamethrin residues in post-harvest treated wheat with regard to baby-food safety requirements

    Microsoft Academic Search

    Anna M. Balinova; Rositsa I. Mladenova; Deyana D. Shtereva

    2007-01-01

    The effects of storage intervals and of milling procedures on dissipation of deltamethrin residues in post-harvest treated wheat grain were studied with the aim to obtain scientific data on compliance of the processed products with the safety requirements concerning baby foods. The insecticide formulation was applied on stored wheat at a recommended rate of active ingredient of 0.5?mg?kg and at

  17. Post-licensure safety surveillance for human papillomavirus-16/18-AS04-adjuvanted vaccine: more than 4?years of experience

    PubMed Central

    Angelo, Maria-Genalin; Zima, Julia; Tavares Da Silva, Fernanda; Baril, Laurence; Arellano, Felix

    2014-01-01

    Purpose To summarise post-licensure safety surveillance over more than 4?years of routine use of the human papillomavirus-16/18-AS04-adjuvanted vaccine (HPV-16/18 vaccine: Cervarix®, GlaxoSmithKline, Belgium). Methods We describe global post-licensure passive surveillance data based on routine pharmacovigilance from 18 May 2007 until 17 November 2011 and enhanced surveillance implemented during the 2-year national immunisation programme in the UK (school years 2008–2010). Results Spontaneous reports from countries worldwide showed a similar pattern for the most frequently reported adverse events after HPV-16/18 vaccination. No patterns or trends were observed for potential immune-mediated diseases after vaccination. Observed incidences of Bell's palsy and confirmed Guillain–Barré syndrome were within the expected range in the general population. Outcomes of pregnancy in women who were inadvertently exposed to HPV-16/18 vaccine during pregnancy, were in line with published reports for similar populations. Enhanced surveillance of adverse events in the UK triggered a review of cases of anaphylaxis, angioedema and syncope reports, leading to an update to the prescribing information. Conclusion Collaborative partnerships between industry and national regulatory agencies facilitated rapid notification and transfer of safety information, allowing for rapid responses in the event of a safety signal of adverse event of concern. More than 4?years of post-licensure experience may provide confidence to providers and the public about the safety profile of HPV-16/18 vaccine in routine use. The safety profile appears to be consistent with pre-licensure data reporting that HPV-16/18 vaccine has an acceptable benefit–risk profile in adolescent girls and women. PMID:24644078

  18. Pooled Analysis of Rofecoxib Placebo-Controlled Clinical Trial Data: Lessons for Post-Market Pharmaceutical Safety Surveillance

    PubMed Central

    Ross, Joseph S.; Madigan, David; Hill, Kevin P.; Egilman, David S.; Wang, Yongfei; Krumholz, Harlan M.

    2010-01-01

    Background In September 2004, rofecoxib was voluntarily withdrawn from the worldwide market. Our objective was to determine whether and when analysis of published and unpublished placebo-controlled trials could have revealed cardiovascular risk associated with rofecoxib before its withdrawal as an example to inform future post-market pharmaceutical safety surveillance efforts. Methods We conducted a cumulative subject-level pooled analysis of data from all randomized, placebo-controlled trials of rofecoxib conducted by the manufacturer before September 2004. Our main outcome measurement was incidence of any investigator-reported death from any cause or cardiovascular thromboembolic (CVT) adverse event. Results We identified 30 randomized, placebo-controlled trials of rofecoxib that enrolled 20,152 subjects. Trial duration ranged from 4 weeks to 4 years, enrollment ranged from 17 to 2586 subjects prescribed either rofecoxib or placebo, and rofecoxib dosage ranged from 12.5 mg to 50 mg. As of December 2000, 21 (70%) of these trials had been completed and the risk of CVT adverse event or death was greater among subjects assigned to rofecoxib, with the difference being borderline statistically significant (Rate Ratio [RR]=2.18, 95% Confidence Interval [CI], 0.93–5.81; p=0.07). Subsequently collected data strengthened the statistical association (as of June 2001: RR=1.35, 95% CI, 1.00–1.96; p=0.05; as of April 2002: RR=1.39, 95% CI, 1.07–1.80; p=0.02). Conclusion Cumulative pooled analysis of all randomized, placebo-controlled trials demonstrates a progressing trend toward increased cardiovascular risk associated with rofecoxib compared with placebo as early as December 2000, reaching a P value of 0.05 by June 2001, nearly 3 and a half years before the manufacturer’s voluntary market withdrawal. PMID:19933959

  19. Comprehensive property retrieval and measurement of concrete spalling using machine vision for post-earthquake safety assessments

    NASA Astrophysics Data System (ADS)

    German, Stephanie; Brilakis, Ioannis; DesRoches, Reginald

    2012-04-01

    Current procedures in post-earthquake safety and structural assessment are performed by a skilled triage team of structural engineers/certified inspectors. These procedures, in particular the physical measurement of the damage properties, are time-consuming and qualitative in nature. Spalling has been accepted as an important indicator of significant damage to structural elements during an earthquake, and thus provides a sound springboard for a model in machine vision automated assessment procedures as is proposed in this research. Thus, a novel method that automatically detects regions of spalling on reinforced concrete columns and measures their properties in image data is the specific focus of this work. According to this method, the region of spalling is first isolated by way of a local entropy-based thresholding algorithm. Following this, the properties of the spalled region are depicted by way of classification of the extent of spalling on the column. The region of spalling is sorted into one of three categories by way of a novel global entropy-based adaptive thresholding algorithm in conjunction with well-established image processing methods in template matching and morphological operations. These three categories are specified as the following: (1) No spalling; (2) Spalling of cover concrete; and (3) Spalling of the core concrete (exposing reinforcement). In addition, the extent of the spalling along the length of the column is quantified. The method was tested on a database of damaged RC column images collected after the 2010 Haiti Earthquake, and comparison of the results with manual measurements indicate the validity of the method.

  20. Efficacy and safety of cross-linked hyaluronic acid single injection on osteoarthritis of the knee: a post-marketing Phase IV study

    PubMed Central

    Bashaireh, Khaldoon; Naser, Ziad; Hawadya, Khaled Al; Sorour, Sorour; Al-Khateeb, Rami Nabeel

    2015-01-01

    Purpose The primary objective of this study was to evaluate the efficacy, safety, and duration of action of viscosupplementation with Crespine® Gel over a 9-month period. Materials and methods The study was a post-marketing Phase IV study. A total of 109 participants with osteoarthritis of the knee (grades 1–4) in the tibio–femoral compartment were recruited in Jordan. Data were collected from each participant during the baseline visit. Each participant received Crespine® Gel injection, and follow-up visits took place at 3 months, 6 months, and 9 months post-injection. Main outcome measure(s) An assessment of participants by phone was conducted at 1 month, 2 months, 4 months, 5 months, 7 months, and 8 months post-injection. Western Ontario and McMaster Universities Arthritis Index questionnaires were completed during each visit. A 72-hour visit questionnaire was used to assess the safety of the injection. Statistical analysis included a two-sided 95% confidence interval for the difference between pain scores across visits, and the percent change from baseline was calculated. Main results The full analysis included 84 participants who gave their informed consent and finished the necessary baseline and follow-up visits needed to assess efficacy and safety. Peak improvement was noted at 5 months post-injection, when pain and physical performance scores had decreased to 2.60 and 9.90, respectively, and the stiffness score was 0.33. The peak improvement in stiffness was noted at 8 months post-injection, when the stiffness score had decreased to 0.32. Significant improvements were still apparent at 9 months post-injection, when the pain score was 3.36, the stiffness score was 0.42, and the physical performance score was 11.5. All side effects were local and transient, and included pain, swelling, and redness of the knee. Most side effects were treated. Conclusion Hyaluronan should be encouraged as an alternative or adjunct treatment to oral analgesics to reduce their required doses, and delay potential future surgical intervention.

  1. An evaluation of efficacy and safety of reboxetine in elderly patients affected by “retarded” post-stroke depression

    Microsoft Academic Search

    Liborio Rampello; Alessandro Alvano; Santina Chiechio; Rocco Raffaele; Ignazio Vecchio; Mariano Malaguarnera

    2005-01-01

    Depression occurs frequently in post-stroke patients and appears to be associated with an impairment in their rehabilitation and functional recovery. Although selective serotonin reuptake inhibitors (SSRI) are often used in post-stroke depression (PSD), it has been observed that only a subset of patients is responsive to this treatment. Other patients respond to tricyclic antidepressants or MAO inhibitors, which, however, may

  2. Trading Post

    NSDL National Science Digital Library

    In the wake of COP-4, Resources for the Future (RFF) (described in the August 28, 1998 Scout Report) has posted Webpages on climate change negotiations. One of these, Trading Post, is "a resource for the analysis and reporting of research and writings on 'flexibility mechanisms' -- the Clean Development Mechanism, emissions trading, and Joint Implementation (or activities implemented jointly) -- authorized by the Kyoto Protocol."

  3. 77 FR 52633 - Public Safety and Homeland Security Bureau Seeks Comment on Post-Reconfiguration 800 MHz Band...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-30

    ...800 MHz Band Plan Along the U.S.-Mexico Border AGENCY: Federal Communications...band channel plans along the U.S.-Mexico border. The Public Safety and Homeland...MHz channel plans along the U.S.-Mexico border. DATES: Comments are due on...

  4. 77 FR 28566 - Notice of Request for a New Information Collection (Food Safety Education Campaign-Post-Wave...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-15

    ...national public service advertising campaign to educate...post-survey of members of the target audience and will help gauge awareness of the advertising, attitudes regarding...or behaviors in the target audience over time...recognition of the ads in market. Once the...

  5. 41 CFR 302-9.170 - Under what specific conditions may my agency authorize transportation of a POV to my post of duty...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...POV to my post of duty subsequent to the time of my assignment to that post? 302-9... Pov Transportation Subsequent to the Time of Assignment § 302-9.170 Under...POV to my post of duty subsequent to the time of my assignment to that post?...

  6. 41 CFR 302-9.170 - Under what specific conditions may my agency authorize transportation of a POV to my post of duty...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...POV to my post of duty subsequent to the time of my assignment to that post? 302-9... Pov Transportation Subsequent to the Time of Assignment § 302-9.170 Under...POV to my post of duty subsequent to the time of my assignment to that post?...

  7. 41 CFR 302-9.170 - Under what specific conditions may my agency authorize transportation of a POV to my post of duty...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...POV to my post of duty subsequent to the time of my assignment to that post? 302-9... Pov Transportation Subsequent to the Time of Assignment § 302-9.170 Under...POV to my post of duty subsequent to the time of my assignment to that post?...

  8. 41 CFR 302-9.170 - Under what specific conditions may my agency authorize transportation of a POV to my post of duty...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...POV to my post of duty subsequent to the time of my assignment to that post? 302-9... Pov Transportation Subsequent to the Time of Assignment § 302-9.170 Under...POV to my post of duty subsequent to the time of my assignment to that post?...

  9. 41 CFR 302-9.170 - Under what specific conditions may my agency authorize transportation of a POV to my post of duty...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...POV to my post of duty subsequent to the time of my assignment to that post? 302-9... Pov Transportation Subsequent to the Time of Assignment § 302-9.170 Under...POV to my post of duty subsequent to the time of my assignment to that post?...

  10. Hand Safety

    MedlinePLUS

    ... Hand Safety Fireworks Safety Lawnmower Safety Snowblower Safety Pumpkin Carving Safety Gardening Safety Turkey Carving Safety Removing ... Hand Safety Fireworks Safety Lawnmower Safety Snowblower Safety Pumpkin Carving Safety Gardening Safety Turkey Carving Safety Removing ...

  11. Miglustat (Zavesca(R)) in type 1 Gaucher disease: 5-year results of a post-authorisation safety surveillance programme

    Microsoft Academic Search

    Carla E. M. Hollak; Derralynn Hughes; Schaik van I. N; Barbara Schwierin; Bruno Bembi

    2009-01-01

    PURPOSE: Miglustat (Zavesca(R)) is an orally-available substrate reduction therapy (SRT) for treatment of mild-to-moderate type 1 Gaucher disease (GD1) in adult patients unsuitable for enzyme replacement therapy (ERT). Miglustat has not been evaluated in children with GD1, and is not used during pregnancy and breast-feeding. A non-interventional, prospective, web-based safety surveillance programme was initiated at the time of the European

  12. The flawed basis for FDA post-marketing safety decisions: the example of anti-depressants and children.

    PubMed

    Klein, Donald F

    2006-04-01

    The FDA (February 3, 2005) issued a black box warning that all antidepressants increase the risk of suicidal thinking and behavior in children and adolescents that must be cited in all advertising as well as included in the package insert. Following this, there was a sharp decrease in antidepressant prescriptions for children with uncertain public health impact. The current black box does not claim that these medications increase the risk of completed suicides, although this is the clear implication of the term 'suicidality'. The interpretation by the press is unequivocal that lethal outcomes prompted this action. This review concludes the following: (1) Since no suicide occurred in clinical trials of approximately 4400 children, the analyses relied upon 'suicidality' as a surrogate. (2) The classification of adverse events by the Columbia group necessarily relied on inferences, because the available evidence was not prospectively collected for this purpose. (3) The data analysis relied on a composite variable labeled 'suicidality', an unvalidated, inappropriate surrogate. Specific criticisms of analytic procedures and inferences are presented. The failure of the FDA's post-marketing surveillance system is reviewed. The data necessary for objective evaluations of possible post-marketing harm cannot be gathered by the current process. Proper prospective post-marketing surveillance by linked computerized medical records is a crucial issue that deserves major public and political attention and prompt action. PMID:16395296

  13. Toolbox Safety Talk Golf Cart Safety

    E-print Network

    Pawlowski, Wojtek

    Toolbox Safety Talk Golf Cart Safety Environmental Health & Safety Facilities Safety & Health to Environmental Health & Safety for recordkeeping. Golf carts are utilized on campus for groundskeepers and personal injury. Only trained and authorized personnel may operate golf carts capable of carrying more than

  14. Uncertainty and sensitivity analysis within the post closure Performance and Safety Assessment of the French deep geological radwaste disposal: methodology, tool and examples of results

    NASA Astrophysics Data System (ADS)

    Pepin, G.

    2009-04-01

    Within the framework of the December 30, 1991 french act, Andra submitted to the French Parliament in December 2005 a report on the feasibility of a high-level and long-lived radwaste disposal in the Callovo-Oxfodien clay layer (Meuse/Haute-Marne site). Further to 2006 french act, Andra is now involved in licensing of the reversible disposal up to 2015, which requires a great scientific and technical knowledge. Studies are based on many years of research carried out in France, in particular in Andra's Meuse/Haute-Marne Underground Research Laboratory (MHM URL), and international programs on radwastes, engineered barriers and deep clay formations. Intensive programs on hydraulic, solute transfer and radionuclides behaviour (solubility, retention) were and are carried out on Callovo-Oxfordian argilites (undisturbed and damaged), concrete materials and swelling clay based material, in order to provide a sound database. All these data allowed to perform firstly a sound description of the expected phenomenological evolution of the repository and its geological environment (including release and migration of radionuclides) from operating period to post closure period up to one million years, secondly a sound post-closure performance and safety assessment covering the different waste types (ILLW, HLW). Various safety scenarii were defined to quantify radiological impacts and to evaluate performance of the components and safety functions in post closure using specific indicators (concentration, molar rate, water flux…). According to the RFS III2.f (french safety rule related to deep geological radwaste disposad), there is no risk analysis in post closure and assessments are performed using deterministic situations, models and values. To complete analysis, propagation of uncertainties from models and input data in Performance and Safey Assessment (PA/SA) models is done using both deterministic and multiparametric probabilistic approach, with two main objectives: (i) to quantify the dispersion of results (time, maximum...); this part deals with uncertainty analysis, and (ii) to identify relevant models and input data whose uncertainty manages uncertainty of the results; this part deals with sensitivity analysis. First this paper describes Andra's methodology and numerical tool used. Then it presents results applied to Monte-Carlo probabilistic multi-parametric study on HLW (vitrified waste) disposal, in order to study propagation of uncertainties of input data (Callovo-Oxfordian, EDZ (Excavated Damaged Zone), and Engineering components) on various radionuclide pathways within the disposal. The methodology consists of (i) setting up probabilistic distribution function (pdf), according to the level of knowledge, (ii) sampling all pdf with Latin Hypercube Sampling methods, (iii) ensuring physical coherence in sets of input data, using correlations and constraints, (iv) using integrated computing tool (Alliances platform) to perform calculations. Results focus on: - uncertainty analysis: multi-parametric study shows (i) that transfer through undisturbed argillites remains the main pathway, (ii) a large dispersion (several orders of magnitude) of molar rate at the top of clay layer for the two pathways (undisturbed argillites, and repository structures), which includes reference point of altered scenario, such as seal failure one, and which is close to worst case one. - sensitivity analysis: for undisturbed argillites pathway, calculations highlight that uncertainty on some input data such as adsorption of Iodine, solubility limit of Selenium, diffusion and vertical permeability of undisturbed argillites, manages dispersion of the results. For repository structures pathway, uncertainty on hydraulic properties, such as permeabilities of EDZ, are relevant. This study is important to identify knowledge of parameters which has to be increased in order to reduce dispersion (uncertainty) of each performance assessment indicator. Lessons learnt lead Andra to be involved now in a sound work of setting up new methods and tools to treat uncert

  15. Are the Long-Acting Intramuscular Formulations of Risperidone or Paliperidone Palmitate Associated with Post-Injection Delirium/Sedation Syndrome? An Assessment of Safety Databases

    PubMed Central

    Alphs, Larry; Gopal, Srihari; Karcher, Keith; Kent, Justine; Kern Sliwa, Jennifer; Kushner, Stuart; Nuamah, Isaac; Singh, Jaskaran

    2011-01-01

    Long-acting injectable (LAI) formulations of antipsychotics are valuable treatment alternatives for patients with psychotic disorders, and understanding their safe use is critical. Post-injection delirium/sedation syndrome (PDSS) has been reported following treatment with one atypical antipsychotic LAI. Clinical databases of risperidone LAI and paliperidone palmitate were explored to identify if cases of PDSS had been observed. No cases of PDSS were identified in 15 completed trials of 3,164 subjects (approximately 115,000 injections) or the postmarketing safety database of risperidone LAI. Only one case of PDSS was identified among 10 completed trials (3,817 subjects, 33,906 injections) of paliperidone palmitate—that case having been reported in a patient randomized to treatment with placebo. Examination of these prospective databases finds no evidence that risperidone LAI and paliperidone palmitate are associated with PDSS and suggest that findings seen with another antipsychotic LAI are not generalizable. PMID:21047303

  16. Validation of a physically based catchment model for application in post-closure radiological safety assessments of deep geological repositories for solid radioactive wastes.

    PubMed

    Thorne, M C; Degnan, P; Ewen, J; Parkin, G

    2000-12-01

    The physically based river catchment modelling system SHETRAN incorporates components representing water flow, sediment transport and radionuclide transport both in solution and bound to sediments. The system has been applied to simulate hypothetical future catchments in the context of post-closure radiological safety assessments of a potential site for a deep geological disposal facility for intermediate and certain low-level radioactive wastes at Sellafield, west Cumbria. In order to have confidence in the application of SHETRAN for this purpose, various blind validation studies have been undertaken. In earlier studies, the validation was undertaken against uncertainty bounds in model output predictions set by the modelling team on the basis of how well they expected the model to perform. However, validation can also be carried out with bounds set on the basis of how well the model is required to perform in order to constitute a useful assessment tool. Herein, such an assessment-based validation exercise is reported. This exercise related to a field plot experiment conducted at Calder Hollow, west Cumbria, in which the migration of strontium and lanthanum in subsurface Quaternary deposits was studied on a length scale of a few metres. Blind predictions of tracer migration were compared with experimental results using bounds set by a small group of assessment experts independent of the modelling team. Overall, the SHETRAN system performed well, failing only two out of seven of the imposed tests. Furthermore, of the five tests that were not failed, three were positively passed even when a pessimistic view was taken as to how measurement errors should be taken into account. It is concluded that the SHETRAN system, which is still being developed further, is a powerful tool for application in post-closure radiological safety assessments. PMID:11140712

  17. Efficacy and Safety of Remifemin on Peri-Menopausal Symptoms Induced by Post-Operative GnRH-a Therapy for Endometriosis: A Randomized Study versus Tibolone

    PubMed Central

    Chen, Jiming; Gao, Hongyan; Li, Qin; Cong, Jing; Wu, Jie; Pu, Dahua; Jiang, Guohua

    2014-01-01

    Background The aim of this study was to investigate clinical efficacy and safety of Remifemin on peri-menopausal symptoms in endometriosis patients with a post-operative GnRH-a therapy. Material/Methods We treated 116 women who had endometriosis with either Remifemin (n=56) 20 mg bid po or Tibolone (n=60) 2.5 mg qd po for 12 weeks after GnRH-a injection. The efficacy was evaluated by Kupperman menopausal index (KMI), and hot flash/sweating scores. The safety parameters such as liver and renal functions, lipid profile, endometrial thickness, and serum sex hormone level, as well as the incidence of adverse events were recorded. Results (1) After GnRH-a therapy, KMI and hot flash/sweating scores in both groups increased significantly (P<0.05) but we found no significant difference for KMI (2.87±1.40 for Remifemin and 2.70±1.26 for Tibolone) and hot flash/sweating scores (0.94±1.72 for Remifemin and 1.06±1.78 for Tibolone) between the 2 groups (P>0.05). (2) No statistical change was observed in liver or renal functions and lipid profile in both groups before and after the treatment (P>0.05). The post-therapeutic serum FSH, LH, and E2 level and endometrial thickness decreased remarkably in both groups (P<0.05). E2 level in the Remifemin group was obviously lower than that in the Tibolone group (P<0.05), and FSH and LH levels were strongly higher (P<0.05). No significant difference in thickness were found in either group (P>0.05). The Remifemin group had far fewer adverse events than the Tibolone group (P<0. 05). Conclusions Compared with Tibolone, Remifemin had a similar clinical efficacy and was safer for the peri-menopausal symptoms induced by GnRH-a in endometriosis patients. PMID:25321621

  18. Building an immune-mediated coagulopathy consensus: early recognition and evaluation to enhance post-surgical patient safety

    PubMed Central

    Ness, Paul; Creer, Michael; Rodgers, George M; Naoum, Joseph J; Renkens, Kenneth; Voils, Stacy A; Alexander, W Allan

    2009-01-01

    Topical hemostats, fibrin sealants, and surgical adhesives are regularly used in a variety of surgical procedures involving multiple disciplines. Generally, these adjuncts to surgical hemostasis are valuable means for improving wound visualization, reducing blood loss or adding tissue adherence; however, some of these agents are responsible for under-recognized adverse reactions and outcomes. Bovine thrombin, for example, is a topical hemostat with a long history of clinical application that is widely used alone or in combination with other hemostatic agents. Hematologists and coagulation experts are aware that these agents can lead to development of an immune-mediated coagulopathy (IMC). A paucity of data on the incidence of IMC contributes to under-recognition and leaves many surgeons unaware that this clinical entity, originating from normal immune responses to foreign antigen exposure, requires enhanced post-operative vigilance and judicious clinical judgment to achieve best outcomes. Postoperative bleeding may result from issues such as loosened ties or clips or the occurrence of a coagulopathy due to hemodilution, vitamin K deficiency, disseminated intravascular coagulation (DIC) or post-transfusion, post-shock coagulopathic states. Other causes, such as liver disease, may be ruled out by a careful patient history and common pre-operative liver function tests. Less common are coagulopathies secondary to pathologic immune responses. Such coagulopathies include those that may result from inherent patient problems such as patients with an immune dysfunction related to systemic lupus erythrematosus (SLE) or lymphoma that can invoke antibodies against native coagulation factors. Medical interventions may also provoke antibody formation in the form of self-directed anti-coagulation factor antibodies, that result in problematic bleeding; it is these iatrogenic post-operative coagulopathies, including those associated with bovine thrombin exposure and its clinical context, that this panel was convened to address. The RETACC panel's goal was to attain a logical consensus by reviewing the scientific evidence surrounding IMC and to make recommendations for the clinical recognition, diagnosis and evaluation, and clinical management of these complications. In light of the under-recognition and under-reporting of IMC, and given the associated morbidity, utilization of health care resources, and potential economic impact to hospitals, the panel engaged in a detailed review of peer-reviewed reports of bovine thrombin associated IMC. From that clinical knowledge base, recommendations were developed to guide clinicians in the recognition, diagnosis, and management of this challenging condition. PMID:19463180

  19. Safety and Efficacy of Endoscopic Retrograde Cholangiopancreatography in Patients with Post-Liver Transplant Biliary Complications: Results of a Cohort Study with Long-Term Follow-Up

    PubMed Central

    Sanna, Claudia; Giordanino, Chiara; Giono, Ilaria; Barletti, Claudio; Ferrari, Arnaldo; Recchia, Serafino; Reggio, Dario; Repici, Alessandro; Ricchiuti, Alessandro; Salizzoni, Mauro; Baldi, Ileana; Ciccone, Giovannino; Rizzetto, Mario

    2011-01-01

    Background/Aims Endoscopic retrograde cholangiopancreatography (ERCP) is the standard approach for the management of biliary complications in liver transplant patients; however, its safety and efficacy have not been established in this setting. This study was performed to evaluate the safety and long-term efficacy of ERCP in transplant patients. Methods The case reports of 1,500 liver transplant patients were reviewed. Orthotopic liver transplantation (OLT) patients were matched 1:2 with non-OLT patients and followed-up for long-term outcome (median, 7.4 years). Results Of the 1,500 liver transplant patients, 94 (6.3%) underwent 150 ERCPs after OLT. Anastomotic strictures were present in 45 patients, biliary stones in 24, biliary leaks in 7, papillary stenosis in 2, and primary sclerosing cholangitis in 1. An ERCP success rate of 90.7% was achieved; biliary stenting led to resolution of the bile leak in 7/7 (100%) patients, and biliary stones were removed in 21/24 (87.5%) patients. In addition, 34 of 45 patients with anastomotic stricture underwent endoscopic dilation. We obtained complete resolution in 22/34 (64.7%) patients. OLT patients did not show a higher probability of complications (odds ratio [OR], 1.04), of pancreatitis (OR, 0.80) or of bleeding (OR, 1.34). Conclusions ERCP is safe and effective for the treatment of post-OLT biliary complications, has a low rate of pancreatitis and results in a durable effect. PMID:21927662

  20. [Safety and effectiveness of pemetrexed in patients with non-small cell lung cancer in Japan - analysis of post-marketing surveillance].

    PubMed

    Okubo, Sumiko; Kobayashi, Noriko; Taketsuna, Masanori; Kaneko, Naoya; Enatsu, Sotaro; Nishiuma, Shinichi

    2014-04-01

    The safety and effectiveness of pemetrexed(PEM)in patients with non-small cell lung cancer(NSCLC)were reviewed using data from post-marketing surveillance. Among 699 patients registered from June 2009 to May 2010, 683 patients were analyzed(343, first-line therapy: 340, second-line therapy or beyond). Patient backgrounds were as follows: median age=65 years(16.1%B75 years old); 64.7% male; 91.9% performance status 0-1; 83.2% Stage IV; 99.0% non-squamous cell cancer. Also, 86% of the first-line and 20% of the second-line cohort were receiving a concomitant anti-cancer drug(mostly platinum agents). The incidence rate of adverse drug reactions(ADR)was 76.7%, including serious cases(18.0%). The most common ADRs were decreased white blood cell count(26.8%), decreased neutrophil count(25.3%), anemia(19.2%), decreased platelet count(17.0%), and nausea(23.0%). The incidence of interstitial lung disease, which is a concern during chemotherapy, was 2.6%. Peripheral neuropathy and alopecia, events influencing a patient's quality of life, were less than 1%. The estimated median survival time was 23.2 months[95%CI: 19.8 months-not calculable]in the first-line cohort, and 11.8 months[95% CI: 10.5-13.7 months]in the B second-line cohort. The surveillance results showed no apparent difference in total ADRs in this current study compared to the safety profile established in clinical trials previously conducted in Japan and overseas. These results demonstrate the safety and effectiveness of PEM treatment for NSCLC patients in daily clinical settings. PMID:24743364

  1. 41 CFR 302-9.171 - If circumstances warrant an authorization to transport a POV to my post of duty after my...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...to transport a POV to my post of duty after my assignment to the post...Contracts and Property Management Federal Travel Regulation...to transport a POV to my post of duty after my... No, if circumstances changed after arrival at...

  2. 41 CFR 302-9.175 - When I am authorized to transport a POV, including a replacement POV, to my post of duty...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...post of duty subsequent to the time of my assignment to that post...Property Management Federal Travel Regulation System RELOCATION...Transportation Subsequent to the Time of Assignment § 302-9...post of duty subsequent to the time of my assignment to that...

  3. 41 CFR 302-9.175 - When I am authorized to transport a POV, including a replacement POV, to my post of duty...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...post of duty subsequent to the time of my assignment to that post...Property Management Federal Travel Regulation System RELOCATION...Transportation Subsequent to the Time of Assignment § 302-9...post of duty subsequent to the time of my assignment to that...

  4. 41 CFR 302-9.175 - When I am authorized to transport a POV, including a replacement POV, to my post of duty...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...post of duty subsequent to the time of my assignment to that post...Property Management Federal Travel Regulation System RELOCATION...Transportation Subsequent to the Time of Assignment § 302-9...post of duty subsequent to the time of my assignment to that...

  5. 41 CFR 302-9.175 - When I am authorized to transport a POV, including a replacement POV, to my post of duty...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...post of duty subsequent to the time of my assignment to that post...Property Management Federal Travel Regulation System RELOCATION...Transportation Subsequent to the Time of Assignment § 302-9...post of duty subsequent to the time of my assignment to that...

  6. 41 CFR 302-9.175 - When I am authorized to transport a POV, including a replacement POV, to my post of duty...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...post of duty subsequent to the time of my assignment to that post...Property Management Federal Travel Regulation System RELOCATION...Transportation Subsequent to the Time of Assignment § 302-9...post of duty subsequent to the time of my assignment to that...

  7. Advanced Bio-Imaging for Nanomaterial Environmental Health and Safety: Post-Event Summary The NNIN-Nano Research Facility at Washington University in St. Louis held a short course, Advanced

    E-print Network

    Subramanian, Venkat

    Advanced Bio-Imaging for Nanomaterial Environmental Health and Safety: Post-Event Summary The NNIN-Nano Research Facility at Washington University in St. Louis held a short course, Advanced Bio the applications and technical requirements of electron microscopy for nano-bio- imaging. An introductory lecture

  8. Analysis of factors influencing the overall effect of racecadotril on childhood acute diarrhea. Results from a real-world and post-authorization surveillance study in Venezuela

    PubMed Central

    Chacón, Jose

    2010-01-01

    Drug efficacy might differ from clinical trial results when performed in clinical daily conditions. Therefore, it is mandatory to conduct trials about effectiveness to improve external validity. This post-authorization, open-label, noncontrolled, prospective, multicenter, observational, and naturalistic trial was designed to search for factors influencing the racecadotril overall effect on childhood acute watery diarrhea in a real-world setting of Venezuela. There were 3,873 children with acute watery diarrhea treated with racecadotril, an enkephalin breakdown blocker plus oral rehydration therapy by 97 pediatricians. Evaluations were carried out daily until emission of two consecutive formed stools or absence of watery bowel movements for 24 hours. The primary end-point was time-to-relief, defined as the time from first racecadotril dose to the last watery bowel movement time. Age, gender, nursing type, nursing status during diarrhea, diarrhea severity, and co-medication were considered as factors in the statistical analysis. The primary end-point was evaluated by factors using UNIANOVA, and post-hoc tests were done. A multiple regression analysis was carried out to identify factors affecting drug performance, racecadotril effectiveness and tolerability overall assessment was searched by physicians and patients, and inter-observer agreement was evaluated by kappa statistics. The mean time-to-relief was 18.5 ± 12.5 hours [95% confidence interval 17.9–19.0] and the diarrhea severity was the only variable with significant and independent weight on racecadotril effectiveness explaining 23% of time-to-relief variance, but even in severe diarrhea cases this time was less than 24 hours. High agreement about satisfactory perception on effectiveness and tolerability was reached among physicians and patients. In conclusion, the racecadotril overall effect, evaluated in a real-world setting of Venezuela, was in agreement with results of some earlier controlled trials. It was only influenced by severity of diarrhea episode, as well as being considered an effective and well tolerated treatment by physicians and patients. PMID:20668711

  9. This is the authors' final version, post peer-review, of an article published in European Urology doi.org/10.1016/j.eururo.2012.07.028. The definitive

    E-print Network

    Pym, David J.

    1 This is the authors' final version, post peer-review, of an article published in European Urology a Academic Urology Unit, University of Aberdeen, Aberdeen, United Kingdom b Division of Urology, University of the Philippines-Manila, Manila, Philippines c Department of Urology, Aberdeen Royal Infirmary, Aberdeen, United

  10. Improvement of the safety of the red pepper spice with FMEA and post processing EWMA quality control charts.

    PubMed

    Ozilgen, Sibel; Bucak, Seyda; Ozilgen, Mustafa

    2013-06-01

    Although there are numerous decades-old studies drawing attention to the presence of aflatoxins in spices, and particularly in red pepper spice, the problem has not been eradicated. In the present study, information presented in the literature, about production method of red pepper spice, its contamination with aflatoxin, and the uncertainty about the data are assessed to find out the points where improvement may be achieved. Failure Mode and Effect Analysis (FMEA) are performed to assess the risk. The highest total risk attributable to chemical plus physical plus biological causes is associated with the washing stage (RPN=363), which is followed by the receiving (RPN=342) and the storage (RPN=342) stages. The highest risk attributable to biological causes (RPN=180) is associated with microbial growth and aflatoxin production due to insufficient control of drying conditions. The highest chemical risk (RPN=144) is found for the presence of unintentional food additives, such as pesticides, herbicides, hormones, and heavy metals in fresh red pepper fruits. EWMA (exponentially weighted average) charts are employed to monitor aflatoxin production during storage. They successfully distinguished between the batches, which turned to be unsafe. Risk associated with unintentional additives may be reduced by using certified additives only. Better drying control will definitely reduce the risk associated with the drying process. Codex Alimentarius plan has worldwide acceptance for assessing safety of the nuts. Risk of accepting the batches contaminated with aflatoxin may be eliminated by applying the Codex Alimentarius sampling plan before putting the dry pulverized red pepper into the storage facility. PMID:24425941

  11. A right hemisphere safety backup at work: hypotheses for deep hypnosis, post-traumatic stress disorder, and dissociation identity disorder.

    PubMed

    Burnand, Gordon

    2013-09-01

    Problem theory points to an a priori relation between six key problems of living, to which people have adapted through evolution. Children are guided through the problems one by one, learning to switch between them automatically and unawares. The first problem of raising hope of certainty (about the environment), is dealt with in the right hemisphere (RH). The second of raising hope of freedom (or power to control), is dealt with in the left hemisphere (LH). Here adventurousness and ignoring the goodness of outcomes potentially create recklessness. When uncertainty rises the RH activates a backup with an override that substitutes immobility, takes over sensory inputs, but allows obedience to parental commands, and a cut-out that stops new work on the freedom problem. Support for the use of the backup by infants is found in the immobility that precedes the crying in strange conditions, and in childhood EEGs. The hypothesis that the backup is active in deep hypnosis imposes accord on findings that appear contradictory. For example it accounts for why observations during deep hypnosis emphasize the activity of the RH, but observations of responsive people not under hypnosis emphasize the activity of the LH. The hypothesis that the backup is active in post-traumatic stress disorder (PTSD) is supported by (a) fMRI observations that could reflect the cut-out, in that part of the precuneus has low metabolism, (b) the recall of motionlessness at the time of the trauma, (c) an argument that playing dead as a defence against predators is illogical, (d) the ease of hypnosis. With dissociative identity disorder (DID), the theory is consistent with up to six alters that have executive control and one trauma identity state where childhood traumas are re-experienced. Support for the cut-out affecting the trauma identity state comes from suppression of part of the precuneus and other parts of the parietal lobe when the trauma identity state is salient and a general script about a trauma is listened to. Support also comes from the ease of hypnosis. The cut-out acts independently of the override. It is linked to low metabolism at the same point in the left precuneus by evidence from all three conditions, hypnosis, PTSD and DID. The concept of dissociation is not required with any of the hypotheses. PMID:23790686

  12. December 8, 2011 Safety Committee Meeting HMSC Safety Committee

    E-print Network

    and posted. 5. Todd Cross mentioned that Zee Medical was missing the HMSC shop kit. 6. The Safety Meeting December 8, 2011 Safety Committee Meeting HMSC Safety Committee December 8, 2011 Present facilities manager and chair the safety committee meetings and be the contact and point person on safety

  13. Environmental Health & Safety

    E-print Network

    Environmental Health & Safety Sub Department Name 480 Oak Rd, Stanford, CA 94305 T 650.723.0448 F 650.725.3468 DEPUTY DIRECTOR, ENVIRONMENTAL HEALTH AND SAFETY Exempt, Full-Time (100% FTE) Posted May 1, 2014 The Department of Environmental Health and Safety (EH&S) at Stanford University seeks

  14. WIN OVER study: Efficacy and safety of olmesartan in Indian hypertensive patients: Results of an open label, non-comparative, multi-centric, post marketing observational study

    PubMed Central

    Kumbla, D.K.; Kumar, S.; Reddy, Y.V.; Trailokya, A.; Naik, M.

    2014-01-01

    Background Hypertension is a global health problem. Multiple classes of drugs including angiotensin receptor blockers (ARBs) are available for the treatment of hypertension. Olmesartan is a relatively newer ARB used in hypertension management. Objective To assess the efficacy and safety of WIN-BP (Olmesartan 20 mg/40 mg) tablet in Indian patients with hypertension. Material and methods An open label, non-comparative, multi-centric, real world post marketing observational study included Indian adult hypertensive patients who were treated with olmesartan 20 mg/40 mg tablet once daily for six months. The primary outcome was reduction of systolic blood pressure (SBP) to <140 mmHg and diastolic BP (DBP) to <90 mmHg at 3 and 6 months after initiation of treatment with olmesartan. All reported adverse events were recorded. Results A total of 8940 patients were enrolled in this study. Baseline SBP of 164 mmHg was reduced to 153, 145, 134 and 130 mmHg at the end of 15 days, 1, 3 and 6 months respectively. Similarly, baseline DBP of 100 mmHg was reduced to 93, 89, 84 and 82 mmHg at the end of 15 days, 1, 3 and 6 months respectively. The reduction in both systolic and diastolic blood pressure from day 15 to month 6 was statistically significant (p < 0.0001) with olmesartan treatment. The percentage of responders for both systolic and diastolic blood pressure increased consistently from day 15 to month 6. Only 0.08% patients reported the adverse events. No serious adverse event was reported in the study. Conclusion Olmesartan 20 mg/40 mg is effective and well tolerated without any serious adverse events in patients with hypertension. PMID:24973841

  15. ISRAEL JOURNAL OF ZOOLOGY, Vol. 49, 2003, pp. 233236 *Author to whom correspondence should be addressed. E-mail: yomtov@post.tau.ac.il

    E-print Network

    Yom-Tov, Yoram

    be addressed. E-mail: yomtov@post.tau.ac.il Accepted September 2003. THE DIET OF THE BARN OWL TYTO ALBA and conservation purposes. We report here on the composition of an assem- blage of barn owl (Tyto alba) pellets

  16. Human pregnancy safety for agents used to treat rheumatoid arthritis: adequacy of available information and strategies for developing post-marketing data

    Microsoft Academic Search

    Christina D Chambers; Zuhre N Tutuncu; Diana Johnson; Kenneth L Jones

    2006-01-01

    For female patients with rheumatoid arthritis, the availability of a host of new disease modifying antirheumatic drugs has raised important questions about fetal safety if a woman becomes pregnant while she is being treated. In addition, there is limited safety information regarding many of the older medications commonly used to treat rheumatoid arthritis in women of reproductive age. Current summary

  17. [Immunogenicity, efficacy and reactogenicity of a human diploid cell strain (HDCS) rabies vaccine in man; recommendations for pre- and post-exposure application (vaccination scheme) (author's transl)].

    PubMed

    Kuwert, E K; Marcus, I; Höher, P G; Werner, J; Iwand, A; Helm, E B

    1977-05-01

    Since 1973 a total of 365 individuals between 4 and 74 years of age were vaccinated with the HDCS-rabies-vaccine produced by Mérieux/Lyon. Only minor local side reactions were observed in some patients. No adverse systemic reactions due to the vaccine occurred in any of the vaccinees. Seroconversion was observed in 100% of the vaccinated subjects. Neutralizing antibodies could be demonstrated in all 365 vaccinees in titers ranging from 1:10 to 1:2238 (0.35 to 72.5 I.U) employing 200 LD 50 of rabies virus in the mouse neutralization test. The persistence of antibodies has been followed up for 2 years. The efficacy of the HDCS-vaccine in post-exposure treatment proved to be reliable. Sixteen patients suffered bites, scratches, cuts und abrasions by proven rabid animals. Another 8 patients had come into close contact with saliva of confirmed rabid animals. None of these patients developed clinical rabies during an observation period now covering 1-3 years. The HDCS-rabies-vaccine, thus, proved to be well tolerated, innocuous and highly protective. Under those aspects, this vaccine must be considered superior to the duck-embryo-vaccine currently licensed in Germany and should be preferred for propylactic and post-exposure vaccination as well. The postexposure schedule elaborated in our laboratory has been adopted and recommended by a WHO expert group on rabies. The data presented here constitute the first report on post-exposure application of HDCS-rabies-vaccine in man. PMID:865381

  18. Phase II, randomized, open, controlled study of AS03-adjuvanted H5N1 pre-pandemic influenza vaccine in children aged 3 to 9 years: follow-up of safety and immunogenicity persistence at 24 months post-vaccination

    PubMed Central

    Díez-Domingo, Javier; Baldó, José-María; Planelles-Catarino, Maria Victoria; Garcés-Sánchez, María; Ubeda, Isabel; Jubert–Rosich, Angels; Marès, Josep; Garcia-Corbeira, Pilar; Moris, Philippe; Teko, Maurice; Vanden Abeele, Carline; Gillard, Paul

    2015-01-01

    Background An AS03-adjuvanted H5N1 influenza vaccine elicited broad and persistent immune responses with an acceptable safety profile up to 6 months following the first vaccination in children aged 3–9 years. Methods In this follow-up of the Phase II study, we report immunogenicity persistence and safety at 24 months post-vaccination in children aged 3–9 years. The randomized, open-label study assessed two doses of H5N1 A/Vietnam/1194/2004 influenza vaccine (1·9 ?g or 3·75 ?g hemagglutinin antigen) formulated with AS03A or AS03B (11·89 mg or 5·93 mg tocopherol, respectively). Control groups received seasonal trivalent influenza vaccine. Safety was assessed prospectively and included potential immune-mediated diseases (pIMDs). Immunogenicity was assessed by hemagglutination-inhibition assay 12 and 24 months after vaccination; cross-reactivity and cell-mediated responses were also assessed. (NCT00502593). Results The safety population included 405 children. Over 24 months, five events fulfilled the criteria for pIMDs, of which four occurred in H5N1 vaccine recipients, including uveitis (n = 1) and autoimmune hepatitis (n = 1), which were considered to be vaccine-related. Overall, safety profiles of the vaccines were clinically acceptable. Humoral immune responses at 12 and 24 months were reduced versus those observed after the second dose of vaccine, although still within the range of those observed after the first dose. Persistence of cell-mediated immunity was strong, and CD4+ T cells with a TH1 profile were observed. Conclusions Two doses of an AS03-adjuvanted H5N1 influenza vaccine in children showed low but persistent humoral immune responses and a strong persistence of cell-mediated immunity, with clinically acceptable safety profiles up to 24 months following first vaccination. PMID:25652873

  19. Safety First!

    ERIC Educational Resources Information Center

    Longfield, Judith

    2006-01-01

    In this article, the author relates how a hands-on chemistry investigation provided her the inspiration to develop an effective safety lesson for her third grade chemistry class. She began the lesson by demonstrating the use of pH indicator paper to show that ordinary household (white) vinegar was an acid. With the students, she wondered aloud…

  20. The Emergency Medical Services Safety Attitudes Questionnaire

    Microsoft Academic Search

    P. Daniel Patterson; David T. Huang; Rollin J. Fairbanks; Henry E. Wang

    2010-01-01

    To characterize safety culture in emergency medical services (EMS), the authors modified a validated safety culture instrument, the Safety Attitudes Questionnaire (SAQ). The pilot instrument was administered to 3 EMS agencies in a large metropolitan area. The authors characterized safety culture across 6 domains: safety climate, teamwork climate, perceptions of management, job satisfaction, working conditions, and stress recognition. The feasibility

  1. Post-marketing safety and effectiveness evaluation of the intravenous anti-influenza neuraminidase inhibitor peramivir (I): a drug use investigation.

    PubMed

    Komeda, Takuji; Ishii, Shingo; Itoh, Yumiko; Ariyasu, Yasuyuki; Sanekata, Masaki; Yoshikawa, Takayoshi; Shimada, Jingoro

    2014-11-01

    Peramivir is the only intravenous formulation among anti-influenza neuraminidase inhibitors currently available. Peramivir was approved for manufacturing and marketing in Japan in January 2010. We conducted a drug use investigation of peramivir from October 2010 to February 2012 and evaluated its safety and effectiveness under routine clinical settings. We collected data of 1309 patients from 189 facilities across Japan and examined safety in 1174 patients and effectiveness in 1158 patients. In total, 143 adverse events were observed with an incidence rate of 7.33% (86/1174). Of these, 78 events were adverse drug reactions (ADRs) with an incidence rate of 4.34% (51/1174). The most frequently reported ADRs were diarrhea, vomiting, and nausea, with incidence rates of 1.87% (22/1174), 0.85% (10/1174), and 0.68% (8/1174), respectively. Moreover, no ADR was reported as serious. ADR onset was within 3 days after the start of peramivir administration in 91.0% (71 events) of the 78 ADRs, and ADRs were resolved or improved within 7 days after onset in 96.2% (75 events) of the 78 ADRs. Neither patient characteristics nor treatment factors appeared to significantly affect drug safety. With regard to effectiveness, the median time to alleviation of both influenza symptoms and fever was 3 days, including the first day of administration. The present study demonstrates the safety and effectiveness of peramivir under routine clinical settings. PMID:25131292

  2. Nuclear safety

    NASA Technical Reports Server (NTRS)

    Buden, D.

    1991-01-01

    Topics dealing with nuclear safety are addressed which include the following: general safety requirements; safety design requirements; terrestrial safety; SP-100 Flight System key safety requirements; potential mission accidents and hazards; key safety features; ground operations; launch operations; flight operations; disposal; safety concerns; licensing; the nuclear engine for rocket vehicle application (NERVA) design philosophy; the NERVA flight safety program; and the NERVA safety plan.

  3. 14 CFR 417.415 - Post-launch and post-flight-attempt hazard controls.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...LICENSING LAUNCH SAFETY Ground Safety § 417.415 Post-launch...full operational capability of safety devices, barriers, and platforms...signal has been sent to a solid rocket motor, the flight termination...ordnance systems. The flight safety system crew must have...

  4. 14 CFR 417.415 - Post-launch and post-flight-attempt hazard controls.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...LICENSING LAUNCH SAFETY Ground Safety § 417.415 Post-launch...full operational capability of safety devices, barriers, and platforms...signal has been sent to a solid rocket motor, the flight termination...ordnance systems. The flight safety system crew must have...

  5. 14 CFR 417.415 - Post-launch and post-flight-attempt hazard controls.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...LICENSING LAUNCH SAFETY Ground Safety § 417.415 Post-launch...full operational capability of safety devices, barriers, and platforms...signal has been sent to a solid rocket motor, the flight termination...ordnance systems. The flight safety system crew must have...

  6. 14 CFR 417.415 - Post-launch and post-flight-attempt hazard controls.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...LICENSING LAUNCH SAFETY Ground Safety § 417.415 Post-launch...full operational capability of safety devices, barriers, and platforms...signal has been sent to a solid rocket motor, the flight termination...ordnance systems. The flight safety system crew must have...

  7. SAFETY ASSESSMENT & CERTIFICATION FOR UAS

    Microsoft Academic Search

    Andrew R Evans; Mark Nicholson

    As part of the certification process to gain clearance to operate in unsegregated airspace, new UASs will require a robust Safety Assessment process. The authors have looked at the civil manned aircraft safety assessment process defined in ARP 4761 and the safety certi fication process in ARP4754, as used to demonstrate compliance with EASA \\/ FAA safety target requirements, in

  8. Comparative study on the immunogenicity and safety of a purified chick embryo cell rabies vaccine (PCECV) administered according to two different simulated post exposure intramuscular regimens (Zagreb versus Essen).

    PubMed

    Mahendra, B J; Narayana, Dh Ashwath; Agarkhedkar, Sharad; Ravish, H S; Harish, B R; Agarkhedkar, Shalaka; Madhusudana, S N; Belludi, Ashwin; Ahmed, Khaleel; Jonnalagedda, Rekha; Vakil, Hoshang; Bhusal, Chiranjiwi; Arora, Ashwani Kumar

    2015-02-01

    Despite availability of effective rabies vaccines, India has the highest global mortality rate for rabies. Low socio-economic communities are most affected due to lack of awareness of the disease and poor compliance to post-exposure prophylactic regimens. Currently, the only approved intramuscular regimen for post-exposure prophylaxis (PEP) against rabies in India is the Essen regimen, which consists of 5 injections administered over 5 separate days in a period of one month. The high number of doses and clinical visits, however, are major reasons for non-compliance, and thus a shorter regimen would be beneficial. In a simulated PEP trial in healthy, adult subjects, this study evaluated whether purified chick embryo cell vaccine (PCECV), administered according to the WHO-recommended 4-dose/3 visit Zagreb vaccination regimen is of equal immunogenicity and safety as the standard Essen regimen in Indian subjects. Two hundred and 50 healthy adults were enrolled and randomized into a Zagreb or Essen group, each receiving PCECV according to their respective regimen. Blood samples were collected on Days 0, 7, 14 and 42 and analyzed using the rapid fluorescent focus inhibition test (RFFIT). By Day 14, all subjects across both groups attained rabies virus neutralizing antibody (RVNA) concentrations of ? 0.5IU/ml. The Zagreb regimen was then demonstrated to be immunologically non-inferior to the Essen regimen by Day 14, which was the primary endpoint of the study. No safety issues were noted and the occurrence of adverse events was similar in both groups (17% and 15%, respectively). NCT01365494. CTRI No.: CTRI/2011/07/001857. PMID:25692792

  9. Post-marketing safety and effectiveness evaluation of the intravenous anti-influenza neuraminidase inhibitor peramivir. II: a pediatric drug use investigation.

    PubMed

    Komeda, Takuji; Ishii, Shingo; Itoh, Yumiko; Ariyasu, Yasuyuki; Sanekata, Masaki; Yoshikawa, Takayoshi; Shimada, Jingoro

    2015-03-01

    Peramivir is the only intravenous formulation among anti-influenza neuraminidase inhibitors currently available. Peramivir was approved for manufacturing and marketing in Japan in January 2010. In October 2010, an additional indication for pediatric use was approved. We conducted a pediatric drug use investigation of peramivir from October 2010 to February 2012 and evaluated its real-world safety and effectiveness in pediatric patients. We collected the data of 1254 peramivir-treated pediatric patients from 161 facilities across Japan and examined the safety in 1199 patients and effectiveness in 1188 patients. In total, 245 adverse events were observed with an incidence rate of 14.01% (168/1199). Of these, 115 events were adverse drug reactions (ADRs) with an incidence rate of 7.67% (92/1199). Common ADRs were diarrhea and abnormal behavior, with incidence rates of 2.50% (30/1199) and 2.25% (27/1199), respectively. Fourteen serious ADRs were observed in 12 patients (1.00%), including 5 cases each of abnormal behavior and neutrophil count decreased. While 87.0% (100 events) of ADRs occurred within 3 days after the initiation of peramivir administration, 87.8% (101 events) resolved or improved within 7 days after onset. Multivariate analyses indicated that the presence or absence of underlying diseases/complications was significantly related to ADR incidence. With regard to effectiveness, the median time to alleviation of both influenza symptoms and fever was 3 days, including the first day of administration. Thus, this study confirms the pediatric safety of peramivir without any concerns about effectiveness under routine clinical settings. PMID:25523716

  10. Efficacy and Safety of Clindamycin Phosphate 1.2% and Tretinoin 0.025% Gel for the Treatment of Acne and Acne-induced Post-inflammatory Hyperpigmentation in Patients with Skin of Color

    PubMed Central

    Young, Cherie M.; Kindred, Chesahna; Taylor, Susan C.

    2012-01-01

    Objective: To assess the efficacy and safety of a topical gel containing clindamycin 1.2% and tretinoin 0.025% for the treatment of acne and acne-induced postinflammatory hyperpigmentation (PIH) in darker skinned patients. Design: Randomized, double-blind, placebo-controlled study. Setting: Two United States clinical sites. Participants: Thirty-three patients 12 years of age or older with skin types IV to VI, mild-to-moderate facial acne, and PIH were enrolled. Measurements: Patients applied clindamycin phosphate/tretinoin gel or a nonmedicated vehicle each evening and a sun protection factor 30 sunscreen daily. Changes in skin erythema and hyperpigmentation were measured using a chromameter and photographic images. Efficacy was assessed using the Evaluators Global Acne Severity Scale, lesion counts, Post-inflammatory Hyperpigmentation Severity Scales and Patient’s Global Assessment Scale. Safety and tolerability were assessed by adverse event reports and a Safety Assessment Scale. Results: The mean (SD) baseline inflammatory lesion count was 11.9 (11.1) in clindamycin/tretinoin-treated patients, decreasing by 5.5 (6.56) after 12 weeks while the mean baseline inflammatory lesion count was 13.6 (11.15) in placebo-treated patients, decreasing by 4.1 (11.36) (p=0.05 for change from baseline, clindamycin/tretinoin vs. placebo). Clindamycin/tretinoin-treated patients generally demonstrated superior efficacy versus placebo treatment. The clindamycin/tretinoin topical gel was well tolerated, causing little or no irritation, although one patient withdrew due to periorbital edema of moderate severity possibly related to clindamycin/tretinoin gel. Conclusion: Although limited by small sample size, the results of this pilot study suggest clindamycin phosphate 1.2% and tretinoin 0.025% topical gel is a safe and effective option for treating mild-to-moderate acne in patients with skin of color. PMID:22798973

  11. A Multidimensional Examination of Campus Safety: Victimization, Perceptions of Danger, Worry about Crime, and Precautionary Behavior among College Women in the Post-Clery Era

    ERIC Educational Resources Information Center

    Wilcox, Pamela; Jordan, Carol E.; Pritchard, Adam J.

    2007-01-01

    Using data from a spring 2004 telephone survey of 1,010 female undergraduate and graduate students at one southeastern state university, the authors examine the objective and subjective experiences with sexual assault or coercion, physical assault, and stalking among college women, paying particular attention to whether actual victimization…

  12. Food safety educational intervention positively influences college students' food safety attitudes, beliefs, knowledge, and self-reported practices.

    PubMed

    Yarrow, Linda; Remig, Valentina M; Higgins, Mary Meck

    2009-01-01

    In this study, the authors evaluated college students' food safety attitudes, beliefs, knowledge, and self-reported practices and explored whether these variables were positively influenced by educational intervention. Students (n=59), were mostly seniors, health or non-health majors, and responsible for meal preparation. Subjects completed a food safety questionnaire (FSQ) prior to educational intervention, which consisted of three interactive modules. Subjects completed module pre-, post-, and post-posttests. The FSQ was also administered after exposure to intervention and five weeks later to determine changes in food safety attitudes, beliefs, knowledge, and self-reported practices. Students' FSQ attitude scores increased from 114 to 122 (p < or = .001); FSQ belief and knowledge scores improved from 86 to 98 (p < or = .001) and from 11 to 13 (p < or = .001), respectively. Food safety knowledge was also measured by module pre- and posttests, and improved significantly after intervention for all students, with health majors having the greatest increase. Intervention resulted in improved food safety self-reported practices for health majors only. The educational intervention appeared effective in improving food safety beliefs and knowledge. For health majors, attitudes and some self-reported practices improved. For all areas, the strongest effects were seen in health majors. PMID:19192742

  13. The Safety of Concurrent Administration of Opioids via Epidural and Intravenous Routes for Post-operative Pain in Pediatric Oncology Patients

    PubMed Central

    Anghelescu, Doralina L.; Ross, Catherine E.; Oakes, Linda L.; Burgoyne, Laura L.

    2008-01-01

    Supplementation of epidural opioid analgesia with intravenous opioids is usually avoided because of concern about respiratory depression. However, the choice of adjunct analgesic agents for pediatric oncology patients is limited. Antipyretic drugs may mask fever in neutropenic patients, and non-steroidal anti-inflammatory agents may exert anti-platelet effects and interact with chemotherapeutic agents. We examined the safety of concurrent use of epidural and intravenous opioids in a consecutive series of 117 epidural infusions in pediatric patients and compared our findings to those reported by other investigators. We observed a 0.85% rate of clinically significant respiratory complications. The single adverse event was associated with an error in dosage. In our experience, the supplementation of epidural opioid analgesia with intravenous opioids has been a safe method of postoperative pain control for pediatric patients with cancer. PMID:18291619

  14. [Safety evaluation of NK 631. Antigenicity, effect on delated hypersensitivity, irritative effect on eye mucous membrane and mutangenicity of pepleomycin (NK 631) (author's transl)].

    PubMed

    Abe, F; Koyu, A; Inoue, H; Yamashita, T; Ezura, H; Yoshizawa, K; Takahashi, K; Yoshioka, O; Matsuda, A

    1978-12-01

    1. Whether NK 631 is antigenic to guinea pigs and rabbits was studied by the methods of active and passive anaphylactic shock tests, Schultz-Dale reaction, passive cutaneous anaphylaxis, Ouchterlony, tanned red cell haemagglutination test and test according to the U.S. Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics. However, none of the tests proved NK 631 to be antigenic. 2. The immunosuppressive effect of NK 631 was studied by delayed hypersensitivity to picryl chloride in normal and L-1210 tumor bearing mice. Therapeutic dosis of NK 631 was no immunosuppressed but toxic dosis of NK 631 was slightly decreased in ear thickness of delayed hypersensitivity. 3. The acute irritative effect of NK 631 and of bleomycin was studied by single instillation to the rabbit eye mucous membrane with 0.1 ml of either of 10, 33 and 100 mg/ml solution of the drugs in physiological saline. The irritative effect of NK 631 on the eye mucous membrane at each concentration was slightly severe than that of bleomycin at the same concentration. However, the manifestations were only mild to moderate dilatation of the conjunctival and nictating membrane blood vessels and eye mucous, and recovered or were mitigated 48 hours after the instillation. No severe changes such as corneal opacity, corneal desquamation, swelling and deaquamation of the conjunctival and nictating membrane were observed. The histopathological examination revealed no striking changes. 4. Mutagenicity of NK 631 and of bleomycin on Salmonella typhimurium strain TA 100 and TA 98 was studied. It was definitely shown that neither NK 631 nor bleomycin exerted any mutagenic action on either test strains. PMID:83409

  15. A Systematic Review of the Efficacy and Safety Experience Reported for Sorafenib in Advanced Renal Cell Carcinoma (RCC) in the Post-Approval Setting

    PubMed Central

    Fishman, Mayer N.; Tomshine, Jin; Fulp, William J.; Foreman, Pamela K.

    2015-01-01

    Background Sorafenib was FDA approved in 2005 for treatment of renal cell carcinoma (RCC) based on the results of the pivotal phase 3 clinical trial, TARGET (Treatment Approaches in Renal Cancer Global Evaluation Trial). Since that time, numerous clinical studies have been undertaken that substantially broaden our knowledge of the use of sorafenib for this indication. Methods We systematically reviewed PubMed, Web of Science, Embase, Cochrane Library, and www.clinicaltrials.gov for prospective clinical studies using single agent sorafenib in RCC and published since 2005. Primary endpoints of interest were progression-free survival (PFS) and safety. PROSPERO International prospective register of systematic reviews #CRD42014010765. Results We identified 30 studies in which 2182 patients were treated with sorafenib, including 1575 patients who participated in randomized controlled phase 3 trials. In these trials, sorafenib was administered as first-, second- or third-line treatment. Heterogeneity among trial designs and reporting of data precluded statistical comparisons among trials or with TARGET. The PFS appeared shorter in second- vs. first-line treatment, consistent with the more advanced tumor status in the second-line setting. In some trials, incidences of grade 3/4 hypertension or hand-foot skin reaction (HFSR) were more than double that seen in TARGET (4% and 6%, respectively). These variances may be attributable to increased recognition of HFSR, or potentially differences in dose adjustments, that could be consequences of increased familiarity with sorafenib usage. Several small studies enrolled exclusively Asian patients. These studies reported notably longer PFS than was observed in TARGET. However, no obvious corresponding differences in disease control rate and overall survival were seen. Conclusions Collectively, more recent experiences using sorafenib in RCC are consistent with results reported for TARGET with no marked changes of response endpoints or new safety signals observed. PMID:25830512

  16. 47 CFR 80.311 - Authority for distress transmission.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES STATIONS IN THE MARITIME SERVICES Safety Watch Requirements and Procedures Distress, Alarm, Urgency and Safety Procedures § 80.311 Authority for distress...

  17. 78 FR 12065 - Patient Safety Organizations: Delisting for Cause for Independent Data Safety Monitoring, Inc.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-21

    ...Agency for Healthcare Research and Quality Patient Safety Organizations: Delisting for Cause...its failure to correct a deficiency. The Patient Safety and Quality Improvement Act of 2005 (Patient Safety Act) authorizes the listing of...

  18. The Strategy for Safety: Preventing Crises through Safety Audits

    ERIC Educational Resources Information Center

    Schwartz, Sara Goldsmith

    2013-01-01

    In this article the author demonstrates the importance of school safety audits and describes what schools should focus on in a safety audit. Ultimately, each school should determine its own safety audit strategy based on its unique circumstances, including the type of community within which it is located, the age of the students it serves, and the…

  19. RADIATION SAFETY OFFICE Campus Radiation Safety Manual UNIVERSITY OF NEW ORLEANS Previous Revision: May 1999

    E-print Network

    Li, X. Rong

    RADIATION SAFETY OFFICE Campus Radiation Safety Manual UNIVERSITY OF NEW ORLEANS Previous Revision, structure, personnel, and responsibilities of individuals for the radiation safety program currently engaged in the radiation safety program are listed in Appendix I 2.2 AUTHORIZATION Authorization

  20. Microbial safety of fresh produce

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The book entitled “Microbial Safety of Fresh Produce” with 23 chapters is divided into following six sections: Microbial contamination of fresh produce, Pre-harvest strategies, post-harvest interventions, Produce safety during processing and handling, Public, legal, and economic Perspectives, and Re...

  1. 5 CFR 2423.25 - Post complaint, prehearing settlements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 2010-01-01 2010-01-01 false Post complaint, prehearing settlements. 2423...AUTHORITY UNFAIR LABOR PRACTICE PROCEEDINGS Post Complaint, Prehearing Procedures § 2423.25 Post complaint, prehearing settlements....

  2. Communicating vaccine safety during the development and introduction of vaccines.

    PubMed

    Kochhar, Sonali

    2015-01-01

    Vaccines are the best defense available against infectious diseases. Vaccine safety is of major focus for regulatory bodies, vaccine manufacturers, public health authorities, health care providers and the public as vaccines are often given to healthy children and adults as well as to pregnant woman. Safety assessment is critical at all stages of vaccine development. Effective, clear and consistent communication of the risks and benefits of vaccines and advocacy during all stages of clinical research (including the preparation, approvals, conduct of clinical trials through the post marketing phase) is critically important. This needs to be done for all major stakeholders (e.g. community members, Study Team, Health Care Providers, Ministry of Health, Regulators, Ethics Committee members, Public Health Authorities and Policy Makers). Improved stakeholder alignment would help to address some of the concerns that may affect the clinical research, licensing of vaccines and their wide-spread use in immunization programs around the world. PMID:25859676

  3. LASER SAFETY GUIDELINES July 26, 2006

    E-print Network

    Holland, Jeffrey

    LASER SAFETY GUIDELINES July 26, 2006 #12;TABLE OF CONTENTS SECTION PAGE PREFACE 3 CHAPTER 1: INTRODUCTION TO LASER SAFETY AT PURDUE UNIVERSITY 4 CHAPTER 2: CONTROL MEASURES I. Introduction6 II 7 V. Equipment Labels9 VI. Area Posting Signs9 CHAPTER 3: LASER SAFETY PROGRAM I. Responsibility

  4. Safety evaluation report related to the operation of Watts Bar Nuclear Plant, Units 1 and 2, Docket Nos. 50-390 and 50-391, Tennessee Valley Authority. Supplement number 20

    SciTech Connect

    NONE

    1996-02-01

    This report supplements the Safety Evaluation Report (SER), NUREG-0847 (June 1982), Supplement No. 1 (September 1982), Supplement No. 2 (January 1984), Supplement No. 3 (January 1985), Supplement No. 4 (March 1985), Supplement No. 5 (November 1990), Supplement No. 6 (April 1991), Supplement No. 7 (September 1991), Supplement No. 8 (January 1992), Supplement No. 9 (June 1992), Supplement No. 10 (October 1992), Supplement No. 11 (April 1993), Supplement No. 12 (October 1993), Supplement No. 13 (April 1994), Supplement No. 14 (December 1994), Supplement No. 15 (June 1995), Supplement No. 16 (September 1995), Supplement No. 17 (October 1995), Supplement No. 18 (October 1995), and Supplement No. 19 (November 1995) issued by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission with respect to the application filed by the Tennessee Valley Authority, as applicant and owner, for licenses to operate the Watts Bar Nuclear Plant, Units 1 and 2 (Docket Nos. 50-390 and 50-391). The facility is located in Rhea County, Tennessee, near the Watts Bar Dam on the Tennessee River. This supplement provides recent information regarding resolution of some of the issues identified in the SER.

  5. Safety Education.

    ERIC Educational Resources Information Center

    Daniels, James H.; And Others

    1980-01-01

    Five articles in this issue focus on safety education in agricultural laboratories. Topics discussed include teacher liability; elements of a safety instruction program; state and federal safety standards; ground fault current protection; and eye protection requirements and equipment. (SK)

  6. Toy Safety

    MedlinePLUS

    ... organizations to advocate for the removal of rare-earth magnets from the marketplace. We put together a ... Safety Child Pedestrian Safety International Walk to School Day Halloween Safety Environmental Task Forces CPS Certification Training ...

  7. Pedestrian Safety

    MedlinePLUS

    ... Travel & Motor Vehicle Safety En Español Travel & Motor Vehicle Safety Pedestrian Safety Main Points Emergency physicians treat ... patients each year who are injured by motor vehicles while walking. Sixty-eight thousand pedestrians were injured ...

  8. Post-emergence herbicides useful in calendula

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Easy and effective weed control is required by growers who are considering new industrial crops. Post-emergence herbicides typically are the products of choice by today’s growers. Unfortunately, post-emergence herbicides with proven safety margins are not known for calendula (Calendula officinalis),...

  9. Picture Post

    NSDL National Science Digital Library

    The Picture Post Network involves individuals, schools, organizations and communities in a systematic monitoring project of their local environment, especially vegetation health. Digital photographs - taken from the same location and positioned in the same direction and orientation - allow individuals, schools, organizations, communities and scientists to monitor a variety of environmental parameters, including plant health, growth, and phenology; erosion and deposition; water levels; and cloud and canopy cover. Participants study change over time in their local area, view NASA satellite imagery on the same days as the pictures, and contribute towards improving their own communities. The website provides instructions for participating, including planning and installing a picture post, monitoring projects, and taking and uploading pictures, and a repository of images. Picture Posts may be added by anyone interested in monitoring a particular location. Currently, Picture Posts sites are active at science centers, schoolyards and gardens, local parks, and nature reserves.

  10. Biologic Safety in Psoriasis

    PubMed Central

    Mansouri, Yasaman

    2015-01-01

    The development of targeted biologic agents has revolutionized the treatment of psoriasis. In this review, the authors focus on the published long-term (? one year) safety data for the use of tumor necrosis factor-? antagonists etanercept, infliximab, and adalimumab, as well as the IL-12/IL-23 antagonist ustekinumab, in adult patients with moderate-to-severe psoriasis. The efficacy of these currently available biologic therapies has been demonstrated in several studies, and their safety profiles are also reassuring. PMID:25741401

  11. 10 CFR 830.205 - Technical safety requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...actions consistent with the technical safety requirement are...authority as designated in the technical safety requirements for nonreactor...facilities. The contractor must report the emergency actions to DOE...rather than the provisions for technical safety requirements in...

  12. 10 CFR 830.205 - Technical safety requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...actions consistent with the technical safety requirement are...authority as designated in the technical safety requirements for nonreactor...facilities. The contractor must report the emergency actions to DOE...rather than the provisions for technical safety requirements in...

  13. 10 CFR 830.205 - Technical safety requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...actions consistent with the technical safety requirement are...authority as designated in the technical safety requirements for nonreactor...facilities. The contractor must report the emergency actions to DOE...rather than the provisions for technical safety requirements in...

  14. [New OP--Initial posting 4/2/09] Operating Policy and Procedure

    E-print Network

    Rock, Chris

    of Risk Management Fire Marshall Managing Director, Environmental Health & Safety/Chair, Radiation/Laser Institutional Safety Committees Safety Advisory Committee Radiation/Laser Safety Committee Institutional[New OP--Initial posting 4/2/09] Operating Policy and Procedure OP 74.13: TTU Safety Committees

  15. The School of Biological and Chemical Sciences Safety Induction Record

    E-print Network

    Chittka, Lars

    Cassell Laser safety Paul Cassell Cryogenic liquids/solids PI or Alan Philcox Field work Paul Fletcher1 The School of Biological and Chemical Sciences Safety Induction Record New staff, post graduate and date should of contact have completed fire safety induction Safety co-ordinator Alan Philcox know how

  16. *Corresponding author. Also corresponding author.

    E-print Network

    Zavrtanik, Marko

    . Frei , V. Granata, E. Grigoriev , F. Hauler , S. Heising , S. Janos , L. Jungermann , Z. Li, C. Lourenc*Corresponding author. Also corresponding author. E-mail address: paula.collins@cern.ch (P. Collins detectors P. Collins *, I.B.M. Barnett , P. Bartalini , W. Bell , P. Berglund , W. de Boer , S. Buontempo

  17. Safety of obesity drugs.

    PubMed

    Greenway, Frank L; Caruso, Mary K

    2005-11-01

    The safety of obesity drugs has historically been poor. This and the stigmatisation of obesity in society ensured that a higher standard of safety for obesity drugs must be met. The authors review the safety disasters of obesity drugs that were withdrawn. The authors then review the safety of presently available drugs--benzphetamine, phendimetrazine, diethylpropion, phentermine, sibutramine and orlistat. The safety of rimonabant, a drug with a pending new drug application that has an independent effect on metabolic syndrome, is also reviewed. The authors compare the stage of obesity drug development to that of hypertension in the 1950s. As new and safer drugs with more downstream mechanisms are developed that have independent effects on the cardiovascular risks associated with obesity, third party reimbursement for obesity medicine is likely to improve. This may lead to obesity being treated like hypertension and other chronic diseases with long-term medication. With improved technological tools, the authors believe this process will be more rapid for obesity than it was for hypertension. PMID:16255666

  18. Divergent Effects of Transformational and Passive Leadership on Employee Safety

    Microsoft Academic Search

    E. Kevin Kelloway; Jane Mullen; Lori Francis

    2006-01-01

    The authors concurrently examined the impact of safety-specific transformational leadership and safety-specific passive leadership on safety outcomes. First, the authors demonstrated via confirmatory factor analysis that safety-specific transformational leadership and safety-specific passive leadership are empirically distinct constructs. Second, using hierarchical regression, the authors illustrated, contrary to a stated corollary of transformational leadership theory (B. M. Bass, 1997), that passive leadership

  19. A comparison of the efficacy and safety of irbesartan/hydrochlorothiazide combination therapy with irbesartan monotherapy in the treatment of moderate or severe hypertension in diabetic and obese hypertensive patients: a post-hoc analysis review.

    PubMed

    Neutel, Joel M

    2011-07-01

    Hypertension is difficult to treat in patients with type 2 diabetes mellitus (T2DM) or obesity. Combination therapies are often required to effectively lower blood pressure (BP) and attain BP goals. In this post-hoc analysis of 2 prospective, randomized, controlled studies in patients with uncontrolled or untreated moderate or severe hypertension, the efficacy and safety of treatment with irbesartan/hydrochlorothiazide (HCTZ) and irbesartan was assessed in 2 separate analyses: patients with diabetes (n=143) and by obesity status (n=1125). Patients received irbesartan/HCTZ (150 mg/12.5 mg titrated to 300 mg/25 mg) or irbesartan (150 mg titrated to 300 mg) for 7 (severe hypertension study) or 12 (moderate hypertension study) weeks. Efficacy comparisons between treatment groups were performed using Fisher's exact tests. After 7 to 8 weeks of treatment, systolic BP (SBP)/diastolic BP (DBP) decreased in patients with diabetes by 26.9/17.8 mm Hg and 21.8/15.8 mm Hg after irbesartan/HCTZ and irbesartan treatment, respectively (P [SBP]=0.09, P [DBP]=0.27). In obese patients (n=544), SBP/DBP decreased by 29.4/20.2 mm Hg and 20.1/15.9 mm Hg after irbesartan/HCTZ and irbesartan treatment, respectively (P<0.0001). More patients with T2DM reached the BP goal of <130/80 mm Hg at week 7 to 8 in the irbesartan/HCTZ group than in the irbesartan group (12% vs 5%), although not statistically significant (P=0.22). Significantly more obese patients reached their respective BP goals in the irbesartan/HCTZ group than in the irbesartan group (48% vs 23%; P<0.0001). Treatment-emergent adverse event rates were similar between treatment groups regardless of the presence of diabetes or body mass index (BMI) status. In patients with moderate or severe hypertension and with a BMI ? 30 kg/m(2), initial treatment with irbesartan/HCTZ combination therapy was more effective than irbesartan monotherapy. PMID:21680997

  20. Material Safety Data Sheets

    NSDL National Science Digital Library

    The Loctite corporation, which manufactures sealants, adhesives and coatings, has recently posted online a searchable database of materials safety information pages. Users enter keywords to retrieve listings of composition, physical properties, toxicity, and stability of compounds. Recommendations for storage and disposal, emergency first aid, and fire management are also provided. The database features Loctite products exclusively, but it does contain substantial listings that researchers and workers handling chemicals might need.

  1. Utah Authors

    NSDL National Science Digital Library

    Brittani

    2009-06-25

    A smattering of Utah's talented children's book authors. The Girls: Shannon Hale Jessica Day George One of her books: Dragon Slippers Lisa Mangum The Boys: Brandon Mull His New York Times Bestselling series: Fablehaven James Dashner s Blog One of his books: The 13th Reality ...

  2. Food Safety

    MedlinePLUS

    ... More Information Health and Nutrition Information for Preschoolers Food Safety Preschoolers' immune systems are still developing. This ... more about food safety Resources for Nutrition & Health Food Groups & Related Topics Fruits Vegetables Grains Protein Foods ...

  3. 10 CFR 60.32 - Conditions of construction authorization.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...uncorrected, could adversely affect safety at any future time, and (4) results of research and development programs being conducted to resolve safety questions. (c) The construction authorization will include restrictions on...

  4. 10 CFR 60.32 - Conditions of construction authorization.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...uncorrected, could adversely affect safety at any future time, and (4) results of research and development programs being conducted to resolve safety questions. (c) The construction authorization will include restrictions on...

  5. Laser Safety in the Laboratory

    ERIC Educational Resources Information Center

    Weichel, H.; And Others

    1974-01-01

    Deals with the subject of laser hazards, laser hazards control, and laser safety practices in the laboratory. Describes four categories of hazards: radiative, electrical, explosive, and toxic, and explains the status of federal regulations that seek to define lazer hazards and control safety standards. (Author/GS)

  6. Safety teams

    Microsoft Academic Search

    Joseph R. Muscatello; Brian P. Heshizer

    2002-01-01

    Background: Safety teams have become a popular means to recognize and prevent injuries in the workplace. In fact, organizations, such as OSHA, NIOSH, NIEHS, DOE, and the Ohio BWC, not only encourage safety teams, but have implemented them in their organizations. However, safety teams may not be legal as defined by NLRB Act Sections 2(5) and 8(a)(2). Objective: To determine

  7. Four worries for safety

    Microsoft Academic Search

    Julien Dutant

    2008-01-01

    Several authors have recently defended a safety condition on knowl- edge according to which one knows only if one's belief couldn't easily have been wrong. The basic understanding of this clause is that S's belief that p is safe iff in all close worlds in which S believes that p, p is true. Here I raise four problems for basic

  8. AEROSPACE SAFETY ADVISORY PANEL

    E-print Network

    AEROSPACE SAFETY ADVISORY PANEL National Aeronautics and Space Administration Washington, DC 20546 VADM National Aeronautics and Space Administration Washington, DC 20546 Dear Mr. Bolden: Pursuant to Section 106(b) of the National Aeronautics and Space Administration Authorization Act of 2005 (P.L. 109

  9. Visiting Author

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Author of Rocket Boys Homer Hickam, Jr. (left) and Marshall Space Flight Center Director Art Stephenson during a conference at Morris Auditorium. Homer Hickam worked at MSFC during the Apollo project years. As a young man, Mr. Hickam always dreamed of becoming a rocket scientist and following in the footsteps fo Wernher von Braun. Years later he would see his dream realized and had written Rocket Boys commemorating his life and the people at MSFC.

  10. 48 CFR 23.1001 - Authorities.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND...Requirements 23.1001 Authorities. (a) Emergency Planning and Community Right-to-Know Act of 1986, 42...

  11. 48 CFR 23.1001 - Authorities.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND...Requirements 23.1001 Authorities. (a) Emergency Planning and Community Right-to-Know Act of 1986, 42...

  12. 48 CFR 23.1001 - Authorities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND...Requirements 23.1001 Authorities. (a) Emergency Planning and Community Right-to-Know Act of 1986, 42...

  13. 48 CFR 23.1001 - Authorities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND...Requirements 23.1001 Authorities. (a) Emergency Planning and Community Right-to-Know Act of 1986, 42...

  14. 48 CFR 23.1001 - Authorities.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND...Requirements 23.1001 Authorities. (a) Emergency Planning and Community Right-to-Know Act of 1986, 42...

  15. 48 CFR 223.7302 - Authorities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Minimizing the Use of Materials Containing Hexavalent Chromium 223.7302 Authorities. (a) Executive Order 13423 of January 24, 2007, Strengthening Federal Environmental,...

  16. 48 CFR 223.7302 - Authorities.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Minimizing the Use of Materials Containing Hexavalent Chromium 223.7302 Authorities. (a) Executive Order 13423 of January 24, 2007, Strengthening Federal Environmental,...

  17. 48 CFR 223.7302 - Authorities.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Minimizing the Use of Materials Containing Hexavalent Chromium 223.7302 Authorities. (a) Executive Order 13423 of January 24, 2007, Strengthening Federal Environmental,...

  18. 48 CFR 23.201 - Authorities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...REGULATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE...WORKPLACE Energy and Water Efficiency and Renewable Energy 23.201 Authorities. (a)...

  19. 10 CFR 63.31 - Construction authorization.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA Licenses Construction Authorization...construction of a geologic repository operations area at the Yucca Mountain site if it determines: (a) Safety....

  20. 10 CFR 63.31 - Construction authorization.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA Licenses Construction Authorization...construction of a geologic repository operations area at the Yucca Mountain site if it determines: (a) Safety....

  1. 10 CFR 63.31 - Construction authorization.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA Licenses Construction Authorization...construction of a geologic repository operations area at the Yucca Mountain site if it determines: (a) Safety....

  2. 10 CFR 63.31 - Construction authorization.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA Licenses Construction Authorization...construction of a geologic repository operations area at the Yucca Mountain site if it determines: (a) Safety....

  3. 10 CFR 63.31 - Construction authorization.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA Licenses Construction Authorization...construction of a geologic repository operations area at the Yucca Mountain site if it determines: (a) Safety....

  4. 36 CFR 251.53 - Authorities.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    36 Parks, Forests, and Public Property 2 2013-07-01...Authorities. 251.53 Section 251.53 Parks, Forests, and Public Property FOREST...public convenience, or safety; (ii) industrial or commercial purposes, and (iii)...

  5. 36 CFR 251.53 - Authorities.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    36 Parks, Forests, and Public Property 2 2012-07-01...Authorities. 251.53 Section 251.53 Parks, Forests, and Public Property FOREST...public convenience, or safety; (ii) industrial or commercial purposes, and (iii)...

  6. 36 CFR 251.53 - Authorities.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    36 Parks, Forests, and Public Property 2 2011-07-01...Authorities. 251.53 Section 251.53 Parks, Forests, and Public Property FOREST...public convenience, or safety; (ii) industrial or commercial purposes, and (iii)...

  7. 36 CFR 251.53 - Authorities.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    36 Parks, Forests, and Public Property 2 2014-07-01...Authorities. 251.53 Section 251.53 Parks, Forests, and Public Property FOREST...public convenience, or safety; (ii) industrial or commercial purposes, and (iii)...

  8. ASAP Aerospace Safety Advisory Panel

    NASA Technical Reports Server (NTRS)

    2004-01-01

    This is the First Quarterly Report for the newly reconstituted Aerospace Safety Advisory Panel (ASAP). The NASA Administrator rechartered the Panel on November 18,2003, to provide an independent, vigilant, and long-term oversight of NASA's safety policies and programs well beyond Return to Flight of the Space Shuttle. The charter was revised to be consistent with the original intent of Congress in enacting the statute establishing ASAP in 1967 to focus on NASA's safety and quality systems, including industrial and systems safety, risk-management and trend analysis, and the management of these activities.The charter also was revised to provide more timely feedback to NASA by requiring quarterly rather than annual reports, and by requiring ASAP to perform special assessments with immediate feedback to NASA. ASAP was positioned to help institutionalize the safety culture of NASA in the post- Stafford-Covey Return to Flight environment.

  9. Safety in Riding Programs: A Director's Guide.

    ERIC Educational Resources Information Center

    Kpachavi, Teresa

    1996-01-01

    Camp riding programs should be examined regularly for liability and risk management issues. Elements of a basic safety assessment include requiring proper safety apparel, removing obstructions from riding rings, ensuring doors and gates are closed, requiring use of lead ropes, securing equine medications, banning smoking, posting written…

  10. Environment Health and Safety Hazard Alert

    E-print Network

    Habib, Ayman

    Environment Health and Safety Hazard Alert University of Calgary Environment Health & Safety Hazard Alert INCIDENT DATE : November 22, 2011 SUBJECT : Laboratory Fire Background / Incident Details : A post half an hour. The PD was alerted that there was smoke coming from the oil bath and attempted

  11. Selected Major Issues in Vaccine Safety

    Microsoft Academic Search

    John K. Iskander; Jane Gidudu; Nelson Arboleda; Wan-Ting Huang

    2008-01-01

    Recent examples of the major public health benefits of vaccination include global reductions in measles mortality and record low levels of vaccine-preventable diseases in the United States. Nevertheless, real or perceived vaccine safety issues may adversely impact vaccine programs. Robust post-licensure safety monitoring which combines active and passive surveillance with use of standardized case definitions for adverse events is the

  12. Fifty years of progress in reactor safety

    Microsoft Academic Search

    Okrent

    1992-01-01

    This paper chronicles the major watershed occurrences in the evaluation of current reactor safety principles and concepts. The author covers such issues as the development of siting criteria in the early 1960s, development and design of engineered safety features and emergency cooling systems (ECCS), core meltdown scenarios, anticipated transients without scram (ATWS) issues, WASH-1400 Reactor Safety study employing probabilistic risk

  13. Food Safety Unit Preparation Materials and

    E-print Network

    UNIT 5: Food Safety Unit Preparation Materials and Facilitator Guide #12; #12;Navigating for Success Food Safety Copyright 2007. Do not reproduce or distribute without author permission. Division of Nutritional Sciences, Cornell University. f i Seven Steps of Planning ­ Food Safety WHO: Participants

  14. Evidential Authorization*

    NASA Astrophysics Data System (ADS)

    Blass, Andreas; Gurevich, Yuri; Moskal, Micha?; Neeman, Itay

    Consider interaction of principals where each principal has its own policy and different principals may not trust each other. In one scenario the principals could be pharmaceutical companies, hospitals, biomedical labs and health related government institutions. In another scenario principals could be navy fleets of different and not necessarily friendly nations. In spite of the complexity of interaction, one may want to ensure that certain properties remain invariant. For example, in the navy scenario, each fleet should have enough information from other fleets to avoid unfortunate incidents. Furthermore, one wants to use automated provers to prove invariance. A natural approach to this and many other important problems is to provide a high-level logic-based language for the principals to communicate. We do just that. Three years ago two of us presented the first incarnation of Distributed Knowledge Authorization Language (DKAL). Here we present a new and much different incarnation of DKAL that we call Evidential DKAL. Statements communicated in Evidential DKAL are supposed to be accompanied with sufficient justifications. In general, we construe the term “authorization” in the acronym “DKAL” rather liberally; DKAL is essentially a general policy language. There is a wide spectrum of potential applications of KAL. One ambitious goal is to provide a framework for establishing and maintaining invariants.

  15. Post-market surveillance of GM foods: applicability and limitations of schemes used with pharmaceuticals and some non-GM novel foods

    Microsoft Academic Search

    J.-M Wal; P. A Hepburn; L. J Lea; R. W. R Crevel

    2003-01-01

    Post-market surveillance (PMS) is increasingly required by some regulatory authorities for the marketing approval of GM-Novel Foods. This requirement, in addition to a complete conventional safety assessment, aims to show that unexpected (adverse) effects do not occur after long-term everyday exposure. Large food manufacturers have systems to obtain feedback from consumers on their products. We show that such systems can

  16. 48 CFR 605.502 - Authority.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...PUBLICIZING CONTRACT ACTIONS Paid Advertisements 605.502 Authority. (a) For paid advertisements in newspapers within the United...by overseas posts necessitating paid advertisements in newspapers outside the...

  17. 48 CFR 605.502 - Authority.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...PUBLICIZING CONTRACT ACTIONS Paid Advertisements 605.502 Authority. (a) For paid advertisements in newspapers within the United...by overseas posts necessitating paid advertisements in newspapers outside the...

  18. 48 CFR 605.502 - Authority.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...PUBLICIZING CONTRACT ACTIONS Paid Advertisements 605.502 Authority. (a) For paid advertisements in newspapers within the United...by overseas posts necessitating paid advertisements in newspapers outside the...

  19. 48 CFR 605.502 - Authority.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...PUBLICIZING CONTRACT ACTIONS Paid Advertisements 605.502 Authority. (a) For paid advertisements in newspapers within the United...by overseas posts necessitating paid advertisements in newspapers outside the...

  20. 48 CFR 605.502 - Authority.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...PUBLICIZING CONTRACT ACTIONS Paid Advertisements 605.502 Authority. (a) For paid advertisements in newspapers within the United...by overseas posts necessitating paid advertisements in newspapers outside the...

  1. The Economics of Product Safety

    Microsoft Academic Search

    Walter Y. Oi

    1973-01-01

    The report of the National Commission on Product Safety stated that the American public is being exposed to many unreasonably hazardous products. Further, the post-accident remedies to compensate victims of product-related accidents are inadequate and encourage the continued production of unsafe products. It is believed that a shift in assignment of liability for accident costs from consumers to sellers would

  2. Design and development of safety evaluation system of buildings on a seismic field based on the network platform

    NASA Astrophysics Data System (ADS)

    Sun, Baitao; Zhang, Lei; Chen, Xiangzhao; Zhang, Xinghua

    2015-03-01

    This paper describes a set of on-site earthquake safety evaluation systems for buildings, which were developed based on a network platform. The system embedded into the quantitative research results which were completed in accordance with the provisions from Post-earthquake Field Works, Part 2: Safety Assessment of Buildings, GB18208.2 -2001, and was further developed into an easy-to-use software platform. The system is aimed at allowing engineering professionals, civil engineeing technicists or earthquake-affected victims on site to assess damaged buildings through a network after earthquakes. The authors studied the function structure, process design of the safety evaluation module, and hierarchical analysis algorithm module of the system in depth, and developed the general architecture design, development technology and database design of the system. Technologies such as hierarchical architecture design and Java EE were used in the system development, and MySQL5 was adopted in the database development. The result is a complete evaluation process of information collection, safety evaluation, and output of damage and safety degrees, as well as query and statistical analysis of identified buildings. The system can play a positive role in sharing expert post-earthquake experience and promoting safety evaluation of buildings on a seismic field.

  3. Safety Assessment & Certification for UAS Bristol UAV Systems Conference April 2007

    E-print Network

    Nicholson, Mark

    Assessment process. The authors have looked at the civil manned aircraft safety assessment process defined and clearance from 1998, he developed Safety Management Systems and safety cases for legacy aircraft platforms Safety Assessment process. The authors have looked at the civil manned aircraft safety assessment process

  4. 16 CFR 1105.8 - Costs must be authorized and incurred.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...2010-01-01 2010-01-01 false Costs must be authorized and incurred... CONSUMER PRODUCT SAFETY ACT REGULATIONS CONTRIBUTIONS TO COSTS OF PARTICIPANTS IN DEVELOPMENT...SAFETY STANDARDS § 1105.8 Costs must be authorized and...

  5. The safety leadership.

    PubMed

    Lees, Howard; Faulkner, Bruce

    2010-01-01

    In this paper the authors present a careful consideration about the role of leadership, the fundamental element for the success of Behavior-Based Safety (B-BS) programs within companies. Lees and Faulkner have been training, coaching and writing about Behavior-Based Safety for the last ten years. Considerable data has been gathered during this process and the paramount factor in its success is leadership. An effective leader can create many spectacular successes. The success stories are all predicated on good leadership, without that a good product, great processes and quality people are all wasted and often find themselves on the rocks of frustration. PMID:20518204

  6. ATV Safety

    E-print Network

    Smith, David

    2004-09-16

    , Extension Safety Program The Texas A&M University System Source: All-Terrain Vehicle 2001 Injury and Exposure Studies. Consumer Product Safety Commission. January 2003. Causes of Injuries and Fatalities ATV accidents are rarely caused by design flaws. Most... of those laws are summarized below. Certification requirements. A person may not oper- ate an ATV on public property unless he or she attends a state-approved ATV safety training course and holds a safety certificate, or unless he or she is under...

  7. Lab Safety

    NSDL National Science Digital Library

    The North Carolina Community College System BioNetwork's interactive eLearning tools (IETs) are reusable chunks of training that can be deployed in a variety of courses or training programs. IETs are designed to enhance, not replace hands-on training. Learners are able to enter a hands-on lab experience better prepared and more confident. This particular IET delves into laboratory safety, and covers interacting with the lab environment and a new lab partner. Topics covered include proper dress, housekeeping, safety equipment, mixing, fire safety, and spills. When the module is completed, visitors will be able to demonstrate proper lab safety techniques.

  8. BIOLOGICAL SAFETY O N/A Biosafety Cabinets

    E-print Network

    Entekhabi, Dara

    : _________________________________________________ _________________________________________________ _________________________________________________ NOTES: LASER SAFETY O N/A __LS-1 Area not posted with appropriate 3b/4 laser sign __LS-2 No lighted Other Laser Safety FindingBIOLOGICAL SAFETY O N/A Biosafety Cabinets ___BS-1 Grates obstructed ___BS-2 Not certified

  9. Authors and publication practices.

    PubMed

    Farthing, Michael J G

    2006-01-01

    Although authors are usually considered to be the main perpetrators of research and publication misconduct, any person involved in the process has the potential to offend. Editors may breach ethical standards particularly with respect to conflicts of interest. In the same way that authors are now required to declare competing interests, notably commercial affiliations, financial interests and personal connections, so must editors. Editors can influence the chances of acceptance or rejection of a paper by reviewer selection. Reviewers should also be ready to disclose conflicts of interest. They must ensure that their reviews are evidence based and free from destructive criticism driven by self interest. It seems likely that ultimately we will progressively move towards 'open' peer review in which both the authors and the reviewers are known to each other. There is an urgent need for increased transparency of the relationship between editors and owners. The events of the last few years indicate that unless this interface is fully understood by all parties, conflicts may arise. There is also a need for a radical overhaul in the relationship between journals, journal editors and the biomedical industry. It is now increasingly accepted that all clinical trials should be registered in a centrally held database and that protocols should include the primary and secondary outcome measures and the intended approach to data analysis thereby avoiding opportunistic post hoc analyses. However, the even more radical proposal that journals should cease to publish clinical trials sponsored by industry deserves wider debate. PMID:16501646

  10. Safety issues

    NASA Technical Reports Server (NTRS)

    Rohal, R.

    1991-01-01

    The purpose of the NASA safety review process is to make sure that any system hazards that can endanger the manned flight system are precluded. The systems that address manned flight in a payload safety review process are discussed. The types of basic hazards that are normally addressed on any of the payloads are: contamination, electrical shock, explosions, radiation, and temperature extremes.

  11. Surveying Safety.

    ERIC Educational Resources Information Center

    Gerlovich, Jack A.; Whitsett, John; Lee, Shelley; Parsa Rahul

    2001-01-01

    Describes a safety program for teaching science. In the summer of 1999, specific Wisconsin safety laws, codes, and standards were researched and a training program including content, training sites, and dates was developed. One-day training programs were planned for six regions throughout the state. (SAH)

  12. Safety First

    ERIC Educational Resources Information Center

    Taft, Darryl

    2011-01-01

    Ned Miller does not take security lightly. As director of campus safety and emergency management at the Des Moines Area Community College (DMACC), any threat requires serious consideration. As community college administrators adopt a more proactive approach to campus safety, many institutions are experimenting with emerging technologies, including…

  13. Safety Systems

    ERIC Educational Resources Information Center

    Halligan, Tom

    2009-01-01

    Colleges across the country are rising to the task by implementing safety programs, response strategies, and technologies intended to create a secure environment for teachers and students. Whether it is preparing and responding to a natural disaster, health emergency, or act of violence, more schools are making campus safety a top priority. At…

  14. Safety First Safety Last Safety Always Safety Tip #22

    E-print Network

    Minnesota, University of

    for out-of-control vehicles. Wear hearing protection and a safety vest. Wear a hard hat and safety goggles to protect yourself from branches and flying debris. Wear leather gloves and boots that have hard toes, facilities, and employment without regard to race, color, creed, religion, national origin, sex, age, marital

  15. 78 FR 20619 - First Responder Network Authority Board Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-05

    ...Information Administration First Responder Network Authority Board Meeting AGENCY: National...meeting of the Board of the First Responder Network Authority (FirstNet). DATES: The meeting...the nationwide public safety broadband network. For information on the...

  16. 10 CFR 76.81 - Authorized use of radioactive material.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...radioactive material. 76.81 Section 76.81 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS Safety § 76.81 Authorized use of radioactive material. Unless otherwise authorized by law, the...

  17. 10 CFR 76.81 - Authorized use of radioactive material.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...radioactive material. 76.81 Section 76.81 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS Safety § 76.81 Authorized use of radioactive material. Unless otherwise authorized by law, the...

  18. 10 CFR 76.81 - Authorized use of radioactive material.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...radioactive material. 76.81 Section 76.81 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS Safety § 76.81 Authorized use of radioactive material. Unless otherwise authorized by law, the...

  19. 10 CFR 76.81 - Authorized use of radioactive material.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...radioactive material. 76.81 Section 76.81 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS Safety § 76.81 Authorized use of radioactive material. Unless otherwise authorized by law, the...

  20. 10 CFR 76.81 - Authorized use of radioactive material.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...radioactive material. 76.81 Section 76.81 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS Safety § 76.81 Authorized use of radioactive material. Unless otherwise authorized by law, the...

  1. [Immunological safety of transfusion].

    PubMed

    Muller, Jean-Yves; Chiaroni, Jacques; Garraud, Olivier

    2015-02-01

    Transfusion safety lies on the strict application of measures aimed: at avoiding the occurrence of acute hazards, as far as they can be prevented by e.g. the ABO compatibility for red blood cell concentrates and therapeutic plasma; at reducing the frequency of other acute accidents such as TRALI or post-transfusion GVH (based on the implementation of measures which prove to be largely efficacious though not completely); and at reducing delayed incidents and hazards. The implementation of such immunological safety measures also aim at favoring the transfusion efficacy, in avoiding the lysis of transfused red cells or platelets. Perfect immunological compatibility (match) is impossible because transfused cells expose several hundreds of molecular variants with antigenic properties. Adaptive immunity is largely based upon antigen/antibody conflicts and it predominates in transfusion immunological hazards, but inflammation (as well as other components of innate immunity) is now acknowledged as a major actor of transfusion immunological linked hazards. PMID:25578545

  2. Premarket Safety and Efficacy Studies for ADHD Medications in Children

    PubMed Central

    Bourgeois, Florence T.; Kim, Jeong Min; Mandl, Kenneth D.

    2014-01-01

    Background Attention-deficit hyperactivity disorder (ADHD) is a chronic condition and pharmacotherapy is the mainstay of treatment, with a variety of ADHD medications available to patients. However, it is unclear to what extent the long-term safety and efficacy of ADHD drugs have been evaluated prior to their market authorization. We aimed to quantify the number of participants studied and their length of exposure in ADHD drug trials prior to marketing. Methods We identified all ADHD medications approved by the Food and Drug Administration (FDA) and extracted data on clinical trials performed by the sponsor and used by the FDA to evaluate the drug’s clinical efficacy and safety. For each ADHD medication, we measured the total number of participants studied and the length of participant exposure and identified any FDA requests for post-marketing trials. Results A total of 32 clinical trials were conducted for the approval of 20 ADHD drugs. The median number of participants studied per drug was 75 (IQR 0, 419). Eleven drugs (55%) were approved after <100 participants were studied and 14 (70%) after <300 participants. The median trial length prior to approval was 4 weeks (IQR 2, 9), with 5 (38%) drugs approved after participants were studied <4 weeks and 10 (77%) after <6 months. Six drugs were approved with requests for specific additional post-marketing trials, of which 2 were performed. Conclusions Clinical trials conducted for the approval of many ADHD drugs have not been designed to assess rare adverse events or long-term safety and efficacy. While post-marketing studies can fill in some of the gaps, better assurance is needed that the proper trials are conducted either before or after a new medication is approved. PMID:25007171

  3. Safety Monitoring in Clinical Trials

    PubMed Central

    Yao, Bin; Zhu, Li; Jiang, Qi; Xia, H. Amy

    2013-01-01

    Monitoring patient safety during clinical trials is a critical component throughout the drug development life-cycle. Pharmaceutical sponsors must work proactively and collaboratively with all stakeholders to ensure a systematic approach to safety monitoring. The regulatory landscape has evolved with increased requirements for risk management plans, risk evaluation and minimization strategies. As the industry transitions from passive to active safety surveillance activities, there will be greater demand for more comprehensive and innovative approaches that apply quantitative methods to accumulating data from all sources, ranging from the discovery and preclinical through clinical and post-approval stages. Statistical methods, especially those based on the Bayesian framework, are important tools to help provide objectivity and rigor to the safety monitoring process. PMID:24300399

  4. Safety of high speed guided ground transportation systems: Magnetic and electric field testing of the Washington Metropolitan Area transit authority metrorail system. Volume 1. Analysis. Final report, September 1992-March 1993

    SciTech Connect

    Dietrich, F.M.; Papas, P.N.; Jacobs, W.L.; Ferro, W.E.

    1993-06-01

    The safety of magnetically levitated (maglev) and high speed rail (HSR) trains proposed for application in the United States is the responsibility of the Federal Railroad Administration (FRA). Plans for near future US applications include maglev technology (e.g. in Orlando, FL and Pittsburgh, PA) and high speed rail (e.g. the French Train a Grande Vitesse (TGV) in the Texas Triangle, between Dallas-Fort Worth, Houston and San Antonio, and along five designated high speed corridors). Concerns exist regarding the potential safety, environmental and health effects on the public and on transportation workers due to electrification along new or existing rail corridors, and to maglev and high speed rail operations. Therefore, the characterization of electric and magnetic fields (EMF) produced by both steady (dc) and alternating currents (ac) at power frequency (50 Hz in Europe and 60 Hz in the U.S.) and above, in the Extreme Low Frequency (ELF) range (3-3000 Hz) is of interest. An EMF survey of the Washington Metrorail (WMATA) transit system was performed, as part of a comprehensive comparative EMF safety assessment of the German Transrapid (TR-07) maglev system with other existing and advanced rail systems. The report provides the Analysis (Vol. I) of results, and detailed data and statistical summaries (Vol. II, Appendices) of representative EMF profiles on vehicles and facilities typical of this transit electrotechnology (third rail dc). EMF data represent a range of train operating conditions and locations (in vehicles, stations and waysides), as well as in traffic control and electrical power supply facilities.

  5. Software safety

    NASA Technical Reports Server (NTRS)

    Leveson, Nancy

    1987-01-01

    Software safety and its relationship to other qualities are discussed. It is shown that standard reliability and fault tolerance techniques will not solve the safety problem for the present. A new attitude requires: looking at what you do NOT want software to do along with what you want it to do; and assuming things will go wrong. New procedures and changes to entire software development process are necessary: special software safety analysis techniques are needed; and design techniques, especially eliminating complexity, can be very helpful.

  6. Safety - PPE

    NSDL National Science Digital Library

    This high school activity from the Florida Advanced Technological Education (FL-ATE) Center challenges "your students' ability to identify safety hazards, as they play the role of a safety inspector." On this page, visitors will find a link to two company overview sheets, one with information about TECO, a company that generate and distributes electricity, and another with information about CF Industries, a fertilizer producer. The site also provides a lesson plan, a PowerPoint presentation, and a student handout. This is a great resource to introduce students to hands-on practices in safety inspection in different industries.

  7. Author Rights: Maintaining Control over your Publications

    Microsoft Academic Search

    Brian D Cameron

    2010-01-01

    Many authors have little understanding of publishers' standard copyright transfer agreements and end up signing such agreements without concern for how they may wish to use the publication in future. Since most agreements require authors to surrender all rights to the publisher, they may be unable to re-publish parts of the work, email it to students and colleagues, post it

  8. 5 CFR 2423.41 - Action by the Authority; compliance with Authority decisions and orders.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...AND GENERAL COUNSEL OF THE FEDERAL LABOR RELATIONS AUTHORITY UNFAIR LABOR PRACTICE PROCEEDINGS Post-Transmission and Exceptions...the violator, as appropriate, to cease and desist from any unfair labor practice, or to take any other action to...

  9. POSTED: June 3, 2014 FACULTY OF ENGINEERING

    E-print Network

    Sinnamon, Gordon J.

    including, but not limited to, training in respect of health and safety, harassment and discrimination Western University London, ON N6A 5B9. Canada Tel: +1 519 661 2111 Ext. 81279 Fax: +1 519 661 3498 Email to the Citizenship and Immigration Canada website under Post-Graduation Employment at http

  10. Sun Safety

    MedlinePLUS

    ... Links Buttons and Badges Stay Informed Cancer Home Sun Safety Language: English Español (Spanish) Recommend on Facebook ... other shelter before you need relief from the sun. Your best bet to protect your skin is ...

  11. Food Safety

    MedlinePLUS

    ... in food handling, cooking, and storage can prevent foodborne illness. There are four basic steps to food safety at home: Clean - always wash your fruits and vegetables, hands, counters, and ... reached its expiration date. United States Department of Agriculture

  12. Fire Safety

    MedlinePLUS Videos and Cool Tools

    ... smoke alarms and sprinklers save lives. Dry (Christmas) Tree vs. High Moisture Tree Fire Video by Maury Grundy The U.S. Fire ... when it ignites a maintained (wet) cut Christmas tree and a dry tree. Fire Prevention and Safety ...

  13. Fireworks Safety

    MedlinePLUS

    ... at 350 °F Water boils at 212 °F Fireworks Safety Fireworks are often used to mark special ... fireworks NFPA is opposed to consumer use of fireworks. This includes sparklers and firecrackers. Even sparklers burn ...

  14. Aerospace Safety

    NSDL National Science Digital Library

    This site from SpaceTEC National Aerospace Technical Education Center presents materials on aerospace safety. Topics include hazard communications, lockout/tagout, confined space entry, fall protection, PPE, firefighting and bloodborne pathogens.

  15. ATV Safety

    MedlinePLUS

    ... an ATV: Be at least 16 years old. Health and safety experts strongly discourage ATV use by anyone younger than 16. Operating an ATV demands that drivers be skilled at making quick adjustments, such as ...

  16. Water Safety

    MedlinePLUS

    ... best measure of protection. Back Continue Making Kids Water Wise It's important to teach your kids proper ... water during bad weather, especially lightning. Back Continue Water Park Safety Water parks can be a lot ...

  17. LASER SAFETY POLICY MANUAL ENVIRONMENTAL HEALTH & SAFETY

    E-print Network

    Houston, Paul L.

    LASER SAFETY POLICY MANUAL ISSUED BY ENVIRONMENTAL HEALTH & SAFETY OFFICE OF RADIOLOGICAL SAFETY and GEORGIA TECH LASER SAFETY COMMITTEE July 1, 2010 Revised July 31, 2012 #12;Laser Safety Program 1-1 #12;Laser Safety Policy Manual TABLE OF CONTENTS 1. POLICY AND SCOPE

  18. ENVIRONMENTAL HEALTH AND SAFETY GENERAL SAFETY MANUAL

    E-print Network

    Maroncelli, Mark

    ENVIRONMENTAL HEALTH AND SAFETY GENERAL SAFETY MANUAL May 10, 2002 #12;i Acknowledgements Environmental Health and Safety gratefully acknowledges the assistance provided by the University Safety Council extremely helpful. #12;ii Environmental Health and Safety General Safety Manual Table of Contents Section

  19. Safety Guidelines

    NSDL National Science Digital Library

    James T. Biehle

    2007-01-01

    In order for students to inquire confidently, we must create safe classroom environments. Safety is not just a set of rules but a state of mind, and perhaps, most importantly, it is an attitude and a set of skills that carry over into a students' daily life. But research also shows that the space in which students inquire is vital to their safety and security. This chapter summarizes some of the important factors that contribute to safe laboratory environments.

  20. Hanford Generic Interim Safety Basis

    SciTech Connect

    Lavender, J.C.

    1994-09-09

    The purpose of this document is to identify WHC programs and requirements that are an integral part of the authorization basis for nuclear facilities that are generic to all WHC-managed facilities. The purpose of these programs is to implement the DOE Orders, as WHC becomes contractually obligated to implement them. The Hanford Generic ISB focuses on the institutional controls and safety requirements identified in DOE Order 5480.23, Nuclear Safety Analysis Reports.

  1. Tank Farms Technical Safety Requirements [VOL 1 and 2

    SciTech Connect

    CASH, R.J.

    2000-12-28

    The Technical Safety Requirements (TSRs) define the acceptable conditions, safe boundaries, basis thereof, and controls to ensure safe operation during authorized activities, for facilities within the scope of the Tank Waste Remediation System (TWRS) Final Safety Analysis Report (FSAR).

  2. Nuclear Safety Information Center, Its Products and Services

    ERIC Educational Resources Information Center

    Buchanan, J. R.

    1970-01-01

    The Nuclear Safety Information Center (NSIC) serves as a focal point for the collection, analysis and dissemination of information related to safety problems encountered in the design, analysis, and operation of nuclear facilities. (Author/AB)

  3. 76 FR 77589 - Office of Hazardous Materials Safety; Notice of Application for Special Permits

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-13

    ...Pipeline and Hazardous Materials Safety Administration (PHMSA...Office of Hazardous Materials Safety has received the application...Pipeline and Hazardous Materials Safety Administration, U.S. Department...d).. To authorize the Machinery Factory manufacture,...

  4. 75 FR 5172 - Solicitation of Nominations for Members of the Transit Rail Advisory Committee for Safety

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-01

    ...Nominations for Members of the Transit Rail Advisory Committee for Safety AGENCY...for individuals to serve on the Transit Rail Advisory Committee for Safety (TRACS...and regulations for enhancing safety in rail transit should FTA be given authority...

  5. 77 FR 60042 - Safety Zone; Research Vessel SIKULIAQ Launch, Marinette, WI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-02

    ...13, 2012. The safety zone will encompass all waters...river perpendicularly passing through position 45...anchoring within the safety zone is prohibited unless authorized...Location. The safety zone will encompass all waters...river perpendicularly passing through position...

  6. 77 FR 72998 - Policy Statement on Occupational Safety and Health Standards for Aircraft Cabin Crewmembers

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-07

    ...conditions affecting cabin crewmembers on aircraft by the Occupational Safety and Health Administration (OSHA...that its authority to promote the safety of civil aircraft operations included occupational safety and health for aircraft...

  7. Safety of high speed guided ground transportation systems: Magnetic and electric field testing of the Massachusetts Bay Transportation Authority (MBTA) urban transit system. Volume 2. Appendices. Final report, September 1992-March 1993

    SciTech Connect

    Jacobs, W.L.; Robertson, D.C.; Steiner, G.A.

    1993-06-01

    The safety of magnetically levitated (maglev) and high speed rail (HSR) trains proposed for application in the United States is the responsibility of the Federal Railroad Administration (FRA). Plans for near future US applications include maglev projects (e.g. in Orlando, FL and Pittsburgh, PA) and high speed rail (the French Train a Grande Vitesse (TGV) in the Texas Triangle). The report provides the Analysis (Vol. I) of results, and detailed data and statistical summaries (Vol. II, Appendices) of representative EMF profiles on vehicles and facilities typical of electrotechnologies used in the transit system (3rd rail dc, catenary with pantograph, trolley bus). Each electrotechnology has specific EMF frequency signatures. EMF data represent a range of system operating conditions and locations (in vehicles, stations and waysides), as well as traffic control and electrical power supply facilities.

  8. Aerospace safety advisory panel

    NASA Technical Reports Server (NTRS)

    1995-01-01

    The Aerospace Safety Advisory Panel (ASAP) monitored NASA's activities and provided feedback to the NASA Administrator, other NASA officials and Congress throughout the year. Particular attention was paid to the Space Shuttle, its launch processing and planned and potential safety improvements. The Panel monitored Space Shuttle processing at the Kennedy Space Center (KSC) and will continue to follow it as personnel reductions are implemented. There is particular concern that upgrades in hardware, software, and operations with the potential for significant risk reduction not be overlooked due to the extraordinary budget pressures facing the agency. The authorization of all of the Space Shuttle Main Engine (SSME) Block II components portends future Space Shuttle operations at lower risk levels and with greater margins for handling unplanned ascent events. Throughout the year, the Panel attempted to monitor the safety activities related to the Russian involvement in both space and aeronautics programs. This proved difficult as the working relationships between NASA and the Russians were still being defined as the year unfolded. NASA's concern for the unique safety problems inherent in a multi-national endeavor appears appropriate. Actions are underway or contemplated which should be capable of identifying and rectifying problem areas. The balance of this report presents 'Findings and Recommendations' (Section 2), 'Information in Support of Findings and Recommendations' (Section 3) and Appendices describing Panel membership, the NASA response to the March 1994 ASAP report, and a chronology of the panel's activities during the reporting period (Section 4).

  9. Environmental Health and Safety

    E-print Network

    Shoubridge, Eric

    .janicki@mcgill.ca 8888-43866 ANSI (American National Standards Institute) Class 3b or 4 lasers Biological safety-training/whmis-training] Radiation safety [https://www.mcgill.ca/ehs/safety-training/radiation-safety- training] Laser safety [https://www.mcgill.ca/ehs/safety-training/laser-safetyEnvironmental Health and Safety EHS-FORM-022 v.1.1 Page 1 of 1 Laboratory safety self

  10. Nuclear Power - Post Fukushima

    NASA Astrophysics Data System (ADS)

    Reyes, Jose, Jr.

    2011-10-01

    The extreme events that led to the prolonged power outage at the Fukushima Daiicchi nuclear plant have highlighted the importance of assuring a means for stable long term cooling of the nuclear fuel and containment following a complete station blackout. Legislative bodies, regulatory agencies and industry are drawing lessons from those events and considering what changes, if any, are needed to nuclear power, post Fukushima. The enhanced safety of a new class of reactor designed by NuScale Power is drawing significant attention in light of the Fukushima events. During normal operation, each NuScale containment is fully immersed in a water-filled stainless steel lined concrete pool that resides underground. The pool, housed in a Seismic Category I building, is large enough to provided 30 days of core and containment cooling without adding water. After 30 days, the decay heat generations coupled with thermal radiation heat transfer is completely adequate to remove core decay heat for an unlimited period of time. These passive power systems can perform their function without requiring an external supply of water of power. An assessment of the NuScale passive systems is being performed through a comprehensive test program that includes the NuScale integral system test facility at Oregon State University

  11. Health and Safety Services Safety Guide 21

    E-print Network

    Reading, University of

    Health and Safety Services Safety Guide 21 The safe use of lasers #12;Safety Guide 21 The safe use of lasers Health and Safety Services ii October 2008 The safe use of lasers Contents Summary......................................................................................................................................................................1 2.1. Duties on Heads of School 1 2.2. The University Laser Safety Officer (ULSO) 1 2.3. Duties

  12. Metabolites in safety testing.

    PubMed

    Robison, Timothy W; Jacobs, Abigail

    2009-10-01

    Traditionally, only circulating concentrations of parent drug have been measured in the rodent and nonrodent test species used for drug safety assessments and served as an index of systemic exposure for comparisons to human exposures. Circulating concentrations of metabolites have generally only been measured in specialized circumstances (e.g., parent compound was extensively metabolized). Measurement of only the parent compound is usually sufficient when the metabolite profile in humans is similar to that in at least one of the animal species used in the nonclinical safety assessment. However, it is possible that metabolites formed in humans might not be present in the rodent and nonrodent test species used for drug safety assessments or the metabolites are formed at disproportionately higher concentrations in humans than in the animal test species. Generally, metabolites identified only in human plasma or metabolites present at disproportionately higher concentrations in humans than in any of the animal test species should be considered for safety assessment. The Center for Drug Evaluation and Research (CDER) published a Guidance for Industry on Safety Testing of Drug Metabolites that provides current thinking within CDER on the nonclinical safety assessment of human drug metabolites derived from drug products. The CDER guidance defines human metabolites that can raise a safety concern as those formed at greater than 10% of parent drug systemic exposure at a steady state. By contrast, the more recent International Conference on Harmonization: Guideline on Nonclinical Safety Studies for the Conduct of Human Clinical Trials and Marketing Authorization for Pharmaceuticals (ICH M3[R2]) describes the threshold as 10% of total drug-related exposure. Where they differ, the ICH guidance supersedes the CDER Guidance. The purpose of this article is to provide a perspective on the important details of these guidances from a regulatory review standpoint, as well as discuss some concerns that have arisen from the regulated industry regarding the CDER guidance. Such issues include parent drug that is extensively metabolized, metabolism by intestinal bacteria and metabolites formed by nonclinical test species but not humans. PMID:21083045

  13. Note on evaluating safety performance of road infrastructure to motivate safety competition.

    PubMed

    Han, Sangjin

    2014-11-01

    Road infrastructures are usually developed and maintained by governments or public sectors. There is no competitor in the market of their jurisdiction. This monopolic feature discourages road authorities from improving the level of safety with proactive motivation. This study suggests how to apply a principle of competition for roads, in particular by means of performance evaluation. It first discusses why road infrastructure has been slow in safety oriented development and management in respect of its business model. Then it suggests some practical ways of how to promote road safety between road authorities, particularly by evaluating safety performance of road infrastructure. These are summarized as decision of safety performance indicators, classification of spatial boundaries, data collection, evaluation, and reporting. Some consideration points are also discussed to make safety performance evaluation on road infrastructure lead to better road safety management. PMID:25374273

  14. Post-Polio Syndrome

    MedlinePLUS

    NINDS Post-Polio Syndrome Information Page Condensed from Post-Polio Syndrome Fact Sheet Table of Contents (click to jump ... Trials Organizations Additional resources from MedlinePlus What is Post-Polio Syndrome? Post-polio syndrome (PPS) is a ...

  15. Medication Safety

    Microsoft Academic Search

    Carol A. Keohane; David W. Bates

    2008-01-01

    Since the 1999 landmark report by the Institute of Medicine, ''To Err is Human,'' increasing attention has been directed toward patient safety in the United States, and in fact world wide. This report estimated that approxi- mately 44,000 to 98,000 patients die annually as a result of errors in the care received, and that more than a million patients are

  16. School Safety.

    ERIC Educational Resources Information Center

    The Newsletter of the Comprehensive Center-Region VI, 1999

    1999-01-01

    The articles in this issue dealing with school safety discusses what rural and small urban settings are doing to prevent violence and to educate young people about prosocial alternatives to violence. The research is quite clear that female, minority, and gay students are the targets of a disproportionate amount of harassment and violence, both in…

  17. Sun Safety

    MedlinePLUS

    Everyday Fitness Ideas from the National Institute on Aging at NIH www.nia.nih.gov/Go4Life Sun Safety There are many ways to be physically ... l Share your exercise story. National Institute on ... Go4Life is a registered trademark of the U.S. Department of Health and Human Services.

  18. Safety First Safety Last Safety Always Safety Shoes

    E-print Network

    Minnesota, University of

    , caustics, cutting oils, and petroleum products, neoprene or nitrile boots are often required to prevent Institute's (ANSI) label inside each shoe. Prevent foot injuries by using common safety sense and wearing origin, sex, age, marital status, disability, public as- sistance status, veteran status, or sexual

  19. August 1999 Radiation Safety Manual Section 7 ALARA Program

    E-print Network

    Wilcock, William

    . Radiation Safety Committee Authority ............................................ 7-3 2. Designated of ALARA Principles........................... 7-4 b. Facility Design Clothing .......................................................................... 7-7 H. ALARA Exposure

  20. Scholarly Project Prospectus Posted as information with permission of author

    E-print Network

    Arizona, University of

    screening tools will be analyzed by comparing both patient and provider satisfaction before and after tools and then assess the level of staff competency and patient satisfaction with the new surveys health questionnaire tool and assessing its effectiveness from the patient's perspective. #12;3 2

  1. University of California, San Diego Environment, Health and Safety

    E-print Network

    Russell, Lynn

    above guide rollers Jointer guards installed with auto return Table saw-blade guard, splitter and anti Safety zones around shop equipment HAZARDOUS MATERIALS "No Smoking" signs posted and observed Seismic

  2. 14 CFR 431.71 - Public safety responsibility.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH AND REENTRY OF A REUSABLE LAUNCH VEHICLE (RLV) Post-Licensing Requirements-Reusable Launch Vehicle Mission License Terms and Conditions § 431.71 Public safety...

  3. MACHINE SHOP SAFETY POLICY THE WYSS INSTITUTE

    E-print Network

    Napp, Nils

    (HMS) 617-432-1370 Children's Hospital Boston (CHB) 617-355-7580 Beth Israel Deaconess Medical CenterMACHINE SHOP SAFETY POLICY THE WYSS INSTITUTE FOR BIOLOGICAL INSPIRED ENGINEERING JUNE 2014, AUTHORITY, AND RESOURCES__________________________ 4 2.1 ENVIRONMENTAL HEALTH AND SAFETY

  4. Fifty Years of Driving Safety Research

    Microsoft Academic Search

    John D. Lee

    2008-01-01

    Objective: This brief review covers the 50 years of driving-related research published in Human Factors, its contribution to driving safety, and emerging challenges. Background: Many factors affect driving safety, making it difficult to assess the impact of specific factors such as driver age, cell phone distractions, or collision warnings. Method: The author considers the research themes associated with the approximately

  5. Care needed in repairing safety valves

    Microsoft Academic Search

    Hurrison

    1984-01-01

    Recognizing the need for adequate repairs of ASME\\/National Board stamped safety and safety relief valves, the National Board Executive Committee approved procedures in January 1977 for the issuance of a National Board Certificate of Authorization for the use of a valve repair ''VR'' stamp. The intent of these procedures was to establish realistic standards by which proper repairs could be

  6. Solid waste burial grounds interim safety analysis

    SciTech Connect

    Saito, G.H.

    1994-10-01

    This Interim Safety Analysis document supports the authorization basis for the interim operation and restrictions on interim operations for the near-surface land disposal of solid waste in the Solid Waste Burial Grounds. The Solid Waste Burial Grounds Interim Safety Basis supports the upgrade progress for the safety analysis report and the technical safety requirements for the operations in the Solid Waste Burial Grounds. Accident safety analysis scenarios have been analyzed based on the significant events identified in the preliminary hazards analysis. The interim safety analysis provides an evaluation of the operations in the Solid Waste Burial Grounds to determine if the radiological and hazardous material exposures will be acceptable from an overall health and safety standpoint to the worker, the onsite personnel, the public, and the environment.

  7. Decreasing Ambiguity of the Safety Culture Concept

    SciTech Connect

    Inoue, Shiichiro; Hosoda, Satoshi; Suganuma, Takashi; Monta, Kazuo; Kameda, Akiyuki

    2001-06-17

    The status of the concept of ''safety culture'' is reviewed. It has not sufficiently taken root. One cause for this is the abstract nature of the concept. Organizations must become aware of the necessity of improving safety and have sufficient power to promote this. The culture of safety must be instilled in each employee, so that each of them will feel responsible for identifying weak points in plant safety. The authors devised a tool for a self-assessment of the safety culture. The tool will bring to light information divides, communication gaps, etc. Recognizing the vulnerabilities of the organization by themselves and discussing these weak points among them is the first step to decrease the ambiguity of the safety culture. The next step is to make these gaps known along with agreed-upon countermeasures. The concept of safety culture will be greatly clarified in this way and lead to safer nuclear power plants.

  8. Machine Shop Safety Tips & Safety Guidelines GENERAL SAFETY TIPS

    E-print Network

    Veiga, Pedro Manuel Barbosa

    Machine Shop Safety Tips & Safety Guidelines GENERAL SAFETY TIPS · Safety glasses with side shields distance away from moving machine parts, work pieces, and cutters. · Use hand tools for their designed to oil, clean, adjust, or repair any machine while it is running. Stop the machine and lock the power

  9. September 2011 APPENDIX D: Mandatory Information Posted in the College of Pharmacy and Nutrition

    E-print Network

    Saskatchewan, University of

    September 2011 APPENDIX D: Mandatory Information Posted in the College of Pharmacy and Nutrition College WSEP information posted. Minutes of Chemistry and Pharmacy & Nutrition Local (Thorvaldson) Safety College classrooms and meeting rooms: Fire evaluation route posted on a bulletin board inside

  10. Electrical Fire Safety

    MedlinePLUS

    ... and education. Consumer Product Safety Commission safety guide: electronics and electrical . Electrical safety information on ground fault circuit interrupters, arc fault circuit interrupters, household extension cords, and spotting possible safety problems with electrical ...

  11. OCCUPATIONAL HEALTH AND SAFETY

    E-print Network

    OCCUPATIONAL HEALTH AND SAFETY MANAGEMENT SYSTEM Department of Occupational Health and Safety Revised December 2009 #12;Occupational Health and Safety (OHS) Management System 1. Introduction.............................................................................................................. 3 2.2 Management of Health and Safety

  12. CPSC Safety Guides

    MedlinePLUS

    ... Information Hobbies Playgrounds Pools and Spas Recent OnSafety Blogs March 06, 2015 Daylight Saving Time change smoke ... Product Safety: Jacqueline Jones-Smith Read More OnSafety Blogs Inside CPSC: Recalls Safety Education Regulations, Laws & Standards ...

  13. 33 CFR 154.735 - Safety requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...to operate. (g) Signs indicating that smoking is prohibited are posted in areas where smoking is not permitted. (h) Trucks and other...persons authorized by the operator. (u) Smoking shall be prohibited at the facility...

  14. 33 CFR 154.735 - Safety requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...to operate. (g) Signs indicating that smoking is prohibited are posted in areas where smoking is not permitted. (h) Trucks and other...persons authorized by the operator. (u) Smoking shall be prohibited at the facility...

  15. 33 CFR 154.735 - Safety requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...to operate. (g) Signs indicating that smoking is prohibited are posted in areas where smoking is not permitted. (h) Trucks and other...persons authorized by the operator. (u) Smoking shall be prohibited at the facility...

  16. 33 CFR 154.735 - Safety requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...to operate. (g) Signs indicating that smoking is prohibited are posted in areas where smoking is not permitted. (h) Trucks and other...persons authorized by the operator. (u) Smoking shall be prohibited at the facility...

  17. 33 CFR 154.735 - Safety requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...to operate. (g) Signs indicating that smoking is prohibited are posted in areas where smoking is not permitted. (h) Trucks and other...persons authorized by the operator. (u) Smoking shall be prohibited at the facility...

  18. Safety harness

    DOEpatents

    Gunter, Larry W. (615 Sand Pit Rd., Leesville, SC 29070)

    1993-01-01

    A safety harness to be worn by a worker, especially a worker wearing a plastic suit thereunder for protection in a radioactive or chemically hostile environment, which safety harness comprises a torso surrounding portion with at least one horizontal strap for adjustably securing the harness about the torso, two vertical shoulder straps with rings just forward of the of the peak of the shoulders for attaching a life-line and a pair of adjustable leg supporting straps releasibly attachable to the torso surrounding portion. In the event of a fall, the weight of the worker, when his fall is broken and he is suspended from the rings with his body angled slightly back and chest up, will be borne by the portion of the leg straps behind his buttocks rather than between his legs. Furthermore, the supporting straps do not restrict the air supplied through hoses into his suit when so suspended.

  19. Psychological Science The Author(s) 2013

    E-print Network

    Reber, Paul J.

    Psychological Science XX(X) 1­8 © The Author(s) 2013 Reprints and permissions: sagepub that when people do not engage in transformation of motivation because they are under time pressure or low Corresponding Author: Francesca Righetti, Van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands E

  20. Farm Safety

    PubMed Central

    Wilson, G. S.

    1966-01-01

    Accident and safety are related terms; the higher the accident rate in any industry, the greater is the need for safety measures designed to prevent accidents. This article discusses the accident and safety problems in agriculture, which includes horticulture and forestry. There is still a tendency among townspeople to think of the countryside as peaceful and tranquil, a place where nothing happens very quickly and far removed from violent death or crippling injury. This pleasant rustic picture has undergone a striking change in the last 30 years owing to considerable agricultural mechanization and the development of chemical pesticides, which have brought new dangers to those who live and work on the land. Although men have readily adapted themselves to new machines and methods, they have not proved as able to recognize new dangers and learn how to guard against them. In consequence, accidents have increased to such an extent that the whole industry has realized the need for positive preventive measures. In this country, it is generally accepted that an employer of labour has a responsibility to provide safe working conditions for those he employs. Farm safety legislation goes a little further and usually requires an employer to provide necessary safeguards, with the added requirement on a worker to make use of them. It is a feature of accident prevention work that it never reaches a stage when it can be regarded as complete. Even when a reduction in accidents has been achieved, the effort must be sustained or the trend will be quickly reversed. Images PMID:5904095

  1. HEALTH, SAFETY & INTRODUCTION

    E-print Network

    Sussex, University of

    reporting · DSE Assessments · Risk Assessments · Electrical Safety #12;HEALTH, SAFETY & WELLBEING POLICYHEALTH, SAFETY & WELLBEING NEW STAFF INDUCTION #12;INTRODUCTION · University Health, Safety and Wellbeing Policy · The role of the Health & Safety Office · School/Unit Health & Safety Management

  2. 30 CFR 56.12022 - Authorized persons at major electrical installations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Electricity § 56.12022 Authorized persons at major electrical installations. Areas containing major electrical...

  3. 30 CFR 57.12022 - Authorized persons at major electrical installations.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-UNDERGROUND METAL AND NONMETAL MINES Electricity Surface and Underground § 57.12022 Authorized persons at major electrical installations. Areas containing...

  4. 30 CFR 56.12022 - Authorized persons at major electrical installations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Electricity § 56.12022 Authorized persons at major electrical installations. Areas containing major electrical...

  5. 30 CFR 57.12022 - Authorized persons at major electrical installations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-UNDERGROUND METAL AND NONMETAL MINES Electricity Surface and Underground § 57.12022 Authorized persons at major electrical installations. Areas containing...

  6. 30 CFR 56.12022 - Authorized persons at major electrical installations.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Electricity § 56.12022 Authorized persons at major electrical installations. Areas containing major electrical...

  7. 30 CFR 56.12022 - Authorized persons at major electrical installations.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Electricity § 56.12022 Authorized persons at major electrical installations. Areas containing major electrical...

  8. 30 CFR 57.12022 - Authorized persons at major electrical installations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-UNDERGROUND METAL AND NONMETAL MINES Electricity Surface and Underground § 57.12022 Authorized persons at major electrical installations. Areas containing...

  9. 30 CFR 57.12022 - Authorized persons at major electrical installations.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-UNDERGROUND METAL AND NONMETAL MINES Electricity Surface and Underground § 57.12022 Authorized persons at major electrical installations. Areas containing...

  10. Effects of 28 days of resistance exercise while consuming commercially available pre- and post-workout supplements, NO-Shotgun® and NO-Synthesize® on body composition, muscle strength and mass, markers of protein synthesis, and clinical safety markers in males

    PubMed Central

    2011-01-01

    Purpose The effects of 28 days of heavy resistance training while ingesting the pre- and post-workout supplements, NO-Shotgun® and NO-Synthesize® were determined on body composition, muscle strength and mass, markers of protein synthesis, and clinical safety markers. Methods Nineteen non-resistance-trained males participated in a resistance training program 4 times/week for 28 days while either ingesting 27 g/day of carbohydrate (CARB) or NO-Shotgun® 30 min pre-exercise and 27 g/day of carbohydrate or NO- Synthesize® 30 min post-exercise (NOSS). Data were analyzed with separate 2 × 2 ANOVA (p < 0.05). Results Total body mass was increased in both groups (p = 0.001), but not different between groups. Fat mass was unchanged with CARB, but NOSS decreased fat mass (p = 0.026). Both groups increased fat-free mass (p = 0.001); however, the increases were greater with NOSS (p = 0.023). NOSS underwent greater increases in upper-body (p = 0.023) and lower-body (p = 0.035) strength than CARB. Myofibrillar protein significantly increased in both groups (p = 0.041), with NOSS being greater than CARB (p = 0.049). All of the MHC isoforms were significantly increased in both groups; however, NOSS was greater than CARB for MHC 1 (p = 0.013) and MHC 2A (p = 0.046). All of the myogenic regulatory factors were significantly increased in both groups; however, NOSS was greater than CARB for Myo-D (p = 0.038) and MRF-4 (p = 0.001). For the whole blood and serum clinical chemistry markers, all variables remained within normal clinical ranges. Conclusions Heavy resistance training for 28 days, with NO-Shotgun® and NO-Synthesize® ingested before and after exercise, respectively, significantly improved body composition and increased muscle mass and performance without abnormally impacting any of the clinical chemistry markers. PMID:22050827

  11. The Next Generation of Post-placement and Post-adoption Services: A Complementary Contract Approach.

    ERIC Educational Resources Information Center

    Burnell, Alan; Briggs, Adrian

    1995-01-01

    Discusses postplacement adoption service contracts between East Sussex Social Services and the Post-Adoption Centre (PAC). Describes how PAC originally provided subscription services to local authorities, but when limitations of the subscription service were recognized, a collaborative service with more local authority was developed. (AJH)

  12. Infusing Reliability Techniques into Software Safety Analysis

    NASA Technical Reports Server (NTRS)

    Shi, Ying

    2015-01-01

    Software safety analysis for a large software intensive system is always a challenge. Software safety practitioners need to ensure that software related hazards are completely identified, controlled, and tracked. This paper discusses in detail how to incorporate the traditional reliability techniques into the entire software safety analysis process. In addition, this paper addresses how information can be effectively shared between the various practitioners involved in the software safety analyses. The author has successfully applied the approach to several aerospace applications. Examples are provided to illustrate the key steps of the proposed approach.

  13. AFR-100 safety analyses

    SciTech Connect

    Sumner, T.; Moisseytsev, A.; Wei, T. Y. C. [Argonne National Laboratory, Bldg. 208, 9700 South Cass Avenue, Argonne, IL 60439-4842 (United States)

    2012-07-01

    The Advanced Fast Reactor-100 (AFR-100) is Argonne National Laboratory's 250 MWth metal-fueled modular sodium-cooled pool-type fast reactor concept. [1] A series of accident sequences that focused on the AFR-100's ability to provide protection against reactor damage during low probability accident sequences resulting from multiple equipment failures were examined. Protected and Unprotected Loss of Flow (PLOF and ULOF) and Unprotected Transient Over-Power (UTOP) accidents were simulated using the SAS4A/SASSYS-1 safety analysis code. The large heat capacity of the sodium in the pool-type reactor allows the AFR-100 to absorb large amounts of energy during a PLOF with relatively small temperature increases throughout the system. During a ULOF with a 25-second flow halving time, coolant and cladding temperatures peak around 720 deg. C within the first minute before reactivity feedback effects decrease power to match the flow. Core radial expansion and fuel Doppler provide the necessary feedback during the UTOP to bring the system back to critical before system temperatures exceed allowable limits. Simulation results indicate that adequate ULOF safety margins exist for the AFR-100 design with flow halving times of twenty-five seconds. Significant safety margins are maintained for PLOF accidents as well as UTOP accidents if a rod stop is used. (authors)

  14. Evaluation on roadside safety degree based on grey theory

    Microsoft Academic Search

    Changcheng Li; Hailong Gao; Shengli Chen; Guocai Qi

    2006-01-01

    The issue of roadside safety is significant in China, especially for mountainous rural two-lane highway. Now there are no systematic methods and effective tools to evaluate the roadside safety degree (RSD) in China. In order to help engineers to make an informed decision or take the most effective measures in highway roadside safety improvement program, the author attempt to put

  15. 78 FR 66987 - Railroad Safety Technology Program Grant Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-07

    ...railroad safety and efficiency. The program originally...Program Manager-Advanced Technologies, FRA, at (312) 835-3903...parties whose proposed work may not be of interest...The Railroad Safety Technology Grant Program, authorized...improved safety and network efficiency.'' To be...

  16. 75 FR 15484 - Railroad Safety Technology Program Grant Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-29

    ...railroad safety and efficiency. The program makes...Program Manager- Advanced Technologies (Phone: (312) 835-3903...parties whose proposed work may not be of interest...The Railroad Safety Technology Program (RSTP) authorized...improved safety and network efficiency.'' To be...

  17. Overriding of Drug Safety Alerts in Computerized Physician Order Entry

    Microsoft Academic Search

    HELEEN VAN DER SIJS; ARNOLD VULTO; MARC BERG

    Many computerized physician order entry (CPOE) systems have integrated drug safety alerts. The authors reviewed the literature on physician response to drug safety alerts and interpreted the results using Reason's framework of accident causation. In total, 17 papers met the inclusion criteria. Drug safety alerts are overridden by clinicians in 49% to 96% of cases. Alert overriding may often be

  18. Environmental Health and Instructional Safety Employee Safety

    E-print Network

    de Lijser, Peter

    Program 22 Medical Monitoring 23 Office Safety 23 Personal Protective Equipment 24 Table of Contents #12Environmental Health and Instructional Safety #12;Employee Safety Page 1 To our University an environment for students, faculty, staff, and visitors that will not adversely affect their health and safety

  19. Safety and Efficacy of At-Home Robotic Locomotion Therapy in Individuals with Chronic Incomplete Spinal Cord Injury: A Prospective, Pre-Post Intervention, Proof-of-Concept Study

    PubMed Central

    Rupp, Rüdiger; Schließmann, Daniel; Plewa, Harry; Schuld, Christian; Gerner, Hans Jürgen; Weidner, Norbert; Hofer, Eberhard P.; Knestel, Markus

    2015-01-01

    Background The compact Motorized orthosis for home rehabilitation of Gait (MoreGait) was developed for continuation of locomotion training at home. MoreGait generates afferent stimuli of walking with the user in a semi-supine position and provides feedback about deviations from the reference walking pattern. Objective Prospective, pre-post intervention, proof-of-concept study to test the feasibility of an unsupervised home-based application of five MoreGait prototypes in subjects with incomplete spinal cord injury (iSCI). Methods Twenty-five (5 tetraplegia, 20 paraplegia) participants with chronic (mean time since injury: 5.8 ± 5.4 (standard deviation, SD) years) sensorimotor iSCI (7 ASIA Impairment Scale (AIS) C, 18 AIS D; Walking Index for Spinal Cord Injury (WISCI II): Interquartile range 9 to 16) completed the training (45 minutes / day, at least 4 days / week, 8 weeks). Baseline status was documented 4 and 2 weeks before and at training onset. Training effects were assessed after 4 and 8 weeks of therapy. Results After therapy, 9 of 25 study participants improved with respect to the dependency on walking aids assessed by the WISCI II. For all individuals, the short-distance walking velocity measured by the 10-Meter Walk Test showed significant improvements compared to baseline (100%) for both self-selected (Mean 139.4% ± 35.5% (SD)) and maximum (Mean 143.1% ± 40.6% (SD)) speed conditions as well as the endurance estimated with the six-minute walk test (Mean 166.6% ± 72.1% (SD)). One device-related adverse event (pressure sore on the big toe) occurred in over 800 training sessions. Conclusions Home-based robotic locomotion training with MoreGait is feasible and safe. The magnitude of functional improvements achieved by MoreGait in individuals with iSCI is well within the range of complex locomotion robots used in hospitals. Thus, unsupervised MoreGait training potentially represents an option to prolong effective training aiming at recovery of locomotor function beyond in-patient rehabilitation. Trial Registration German Clinical Trials Register (DKRS) DRKS00005587 PMID:25803577

  20. Safety Gear

    NSDL National Science Digital Library

    2010-01-01

    The following resource is from Lessonopoly, which has created student activities and lesson plans to support the video series, Science of the Olympic Winter Games, created by NBC Learn and the National Science Foundation. Featuring exclusive footage from NBC Sports and contributions from Olympic athletes and NSF scientists, the series will help teach your students valuable scientific concepts. In this lesson, students will consider the design factors that impact safety gear by creating their own “helmet” for an egg. Students will experiment with shape, materials and design in this hands-on project. Students will use their experiences and additional research to debate the topic of having a mandatory helmet law for bicyclists.

  1. Cooperative Secondary Authorization Recycling

    E-print Network

    Cooperative Secondary Authorization Recycling Qiang Wei, Matei Ripeanu, Konstantin Beznosov responses 2. infer approximate responses Secondary Decision Point (SDP) Secondary Authorization Recycling Cooperative Secondary Authorization Recycling SDP SDP SDP Discovery Service each SDP serves only its own PEP

  2. 10 CFR 810.7 - Generally authorized activities.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...authorized, provided no sensitive nuclear technology is transferred: (a) Furnishing...safety of an existing civilian nuclear power plant in a country listed...population posed by a civilian nuclear power plant in such a...

  3. 10 CFR 810.7 - Generally authorized activities.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...authorized, provided no sensitive nuclear technology is transferred: (a) Furnishing...safety of an existing civilian nuclear power plant in a country listed...population posed by a civilian nuclear power plant in such a...

  4. A comparison of commercial/industry and nuclear weapons safety concepts

    SciTech Connect

    Bennett, R.R.; Summers, D.A.

    1996-07-01

    In this paper the authors identify factors which influence the safety philosophy used in the US commercial/industrial sector and compare them against those factors which influence nuclear weapons safety. Commercial/industrial safety is guided by private and public safety standards. Generally, private safety standards tend to emphasize product reliability issues while public (i.e., government) safety standards tend to emphasize human factors issues. Safety in the nuclear weapons arena is driven by federal requirements and memoranda of understanding (MOUs) between the Departments of Defense and Energy. Safety is achieved through passive design features integrated into the nuclear weapon. Though the common strand between commercial/industrial and nuclear weapons safety is the minimization of risk posed to the general population (i.e., public safety), the authors found that each sector tends to employ a different safety approach to view and resolve high-consequence safety issues.

  5. Post-Concussion Syndrome

    Microsoft Academic Search

    Grant L. Iverson; Rael T. Lange

    \\u000a The post-concussion syndrome (a.k.a., post-concussive disorder and post concussional disorder) has been controversial for\\u000a decades. Without question, an acute post-concussion syndrome can be caused by the neurobiology of a mild traumatic brain injury (MTBI). Without question, a post-concussion\\u000a syndrome can be worsened by psychological distress, social psychological factors (e.g., the nocebo effect, iatrogenesis, and\\u000a misattributions), personality characteristics, and co-occurring conditions

  6. Bibliography on Liquefied Natural Gas (LNG) safety

    NASA Technical Reports Server (NTRS)

    Ordin, P. M.

    1976-01-01

    Approximately 600 citations concerning safety of liquefied natural gas and liquid methane are presented. Each entry includes the title, author, abstract, source, description of figures, key references, and major descriptors for retrieving the document. An author index is provided as well as an index of descriptors.

  7. Post-accident radiation monitors

    SciTech Connect

    Laughlin, G.J.; Kathren, R.L.

    1982-01-01

    Under contract to the Nuclear Safety Analysis Center of the Electric Power Research Institute, technical information and specifications were obtained for commercially available radiological monitoring instrumentation designed for use as post-accident monitors. The information was collated and published in the NSAC Handbook of Postaccident Instrumentation (Kathren and Laughlin 1981), and included such data as range, accuracy, precision, sensitivity, and energy dependence of the detector, environmental and seismic limitations of the equipment, the testing program performed to evaluate the equipment, a list of references where the instrumentation is currently installed, and a list of features and accessories available with the monitoring systems. The information presented in this section reveals that, even though a number of vendors claim to be able to meet the guidance of Regulatory Guide 1.97 (USNRC 1980), few have actually conducted tests to verify that their equipment does indeed satisfy the guidance of this Regulatory Guide, and that some of the guidance may in fact be unrealistic.

  8. Rebuilding a safety culture

    Microsoft Academic Search

    George A. Rodney

    1991-01-01

    The development of a culture of safety and NASA since the Challenger accident is reviewed. The technical elements of the strengthened NASA safety program are described, including problem reporting, risk\\/assessment\\/risk management, operational safety, and safety assurance are addressed. Future directions in the development of safety are considered.

  9. ENVIRONMENTAL, HEALTH AND SAFETY

    E-print Network

    California at Davis, University of

    ENVIRONMENTAL, HEALTH AND SAFETY PROGRAMS SPRING 2012 Including: Free Information Session New Program in Health and Safety CONTINUING AND PROFESSIONAL EDUCATION #12;2 Our Health and Safety Programs Workplace Health and Safety Certificate Program For every dollar invested in workplace safety, organizations

  10. March 10, 2014 Message to the Community Regarding Safety and Security

    E-print Network

    the Student Centre with video cameras. The safety and security of the York University community is paramountMarch 10, 2014 Message to the Community Regarding Safety and Security I am pleased to learn safety and security; York Security Services to post dedicated security staff on site in the Food Court

  11. Page 1 of 14 5/2010 LBNL Construction Safety Check List

    E-print Network

    Knowles, David William

    Standards for the Construction Industry; and all other local, state, and federally recognized currentPage 1 of 14 5/2010 LBNL Construction Safety Check List Safety Check List MUST be posted at the job (LBNL) Project Manager for review and final approval the LBNL Construction Safety Engineer must reviewed

  12. Appendix D --Environmental Health & Safety (EH&S) LASER REGISTRATION FORM

    E-print Network

    Jia, Songtao

    Appendix D -- Environmental Health & Safety (EH&S) LASER REGISTRATION FORM Principle Investigator: ___________________EMERGENCY PHONE: __________________ LASER SYSTEM LOCATION: BLDG ______________________ FL/ROOM # ___________________________ USER'SNAME PHONE # Are safety signs posted on door? Yes No Are safety glasses/goggles used? Yes

  13. The new politics of welfare in post-socialist Central Eastern Europe

    E-print Network

    Brown, Dana L., Ph. D. Massachusetts Institute of Technology

    2005-01-01

    This dissertation explores the evolution of welfare systems in post-socialist countries. Utilizing a range of data on social policy legislation and outcomes across countries, the author shows the extent to which post-socialist ...

  14. Herbal Safety

    NSDL National Science Digital Library

    In the past decade, there has been an increased interest in herbal medicines and treatments, both from the mainstream medical community and the general public. One need look no further than the cold drink section of the local supermarket to see the various herbal supplements that are prominently displayed on many drink labels. In an effort to provide critical evaluations of these various herbs and related products, the University of Texas at El Paso has created this important website in order to disseminate information about research findings related to herbal use and to provide these findings in both English and Spanish. There are a number of very helpful fact sheets presented here, including those that the deal with such commonly used medicinal herbs and plants, such as ginseng, chamomile, pumpkin seeds, and St. John's Wort. The Herbal Safety site also contains information on recent medical studies that examine the effectiveness of such medicinal treatments.

  15. Propeller Safety

    NSDL National Science Digital Library

    With over 412,000 members, the Aircraft Owners and Pilots Association (AOPA) continues to work for the issues that are important to its members. One area that they are very concerned with is providing educational materials and opportunities for those persons who would like to enter the aircraft maintenance field. They are continuingly updating their online collection of technical primers and general overviews. One particular noteworthy publication is their "Propeller Safety" manual. Within the document's 12 pages, visitors can learn the basics about working around the propeller, prop mechanics, and key maintenance matters. Along the way, interested parties will find helpful graphics, photographs, and visual aids that will help them identify various problem areas.

  16. Changes in safety attitude and relationship to decreased postoperative morbidity and mortality following implementation of a checklist-based surgical safety intervention

    Microsoft Academic Search

    Alex B Haynes; Thomas G Weiser; William R Berry; Stuart R Lipsitz; Abdel-Hadi S Breizat; E Patchen Dellinger; Gerald Dziekan; Teodoro Herbosa; Pascience L Kibatala; Marie Carmela M Lapitan; Alan F Merry; Richard K Reznick; Bryce Taylor; Amit Vats; Atul A Gawande

    2011-01-01

    ObjectivesTo assess the relationship between changes in clinician attitude and changes in postoperative outcomes following a checklist-based surgical safety intervention.DesignPre- and post intervention survey.SettingEight hospitals participating in a trial of a WHO surgical safety checklist.ParticipantsClinicians actively working in the designated study operating rooms at the eight hospitals.Survey instrumentModified operating-room version Safety Attitudes Questionnaire (SAQ).Main outcome measuresChange in mean safety attitude

  17. Safety Manual Prepared by the

    E-print Network

    Alpay, S. Pamir

    Radiation and Laser Safety 19 Laser Safety 21 Compressed Gas and Cryogenic Safety 22 Electrical Safety 24IMS Safety Manual Prepared by the IMS Safety Committee January 1991 (revised 1/2009) Institute 2 Introduction 3 IMS Laboratory Safety Reporting Policy 4 IMS Safety Committee 5 Fire Safety

  18. Attentional bias toward safety predicts safety behaviors.

    PubMed

    Xu, Yaoshan; Li, Yongjuan; Wang, Guangxi; Yuan, Xiao; Ding, Weidong; Shen, Zhongxiang

    2014-10-01

    Safety studies have primarily focused on how explicit processes and measures affect safety behavior and subsequent accidents and injuries. Recently, safety researchers have paid greater attention to the role of implicit processes. Our research focuses on the role of attentional bias toward safety (ABS) in workplace safety. ABS is a basic, early-stage cognitive process involving the automatic and selective allocation of attentional resources toward safety cues, which reflect the implicit motivational state of employees regarding safety goal. In this study, we used two reaction time-based paradigms to measure the ABS of employees in three studies: two modified Stroop tasks (Studies 1 and 2) and a visual dot-probe task (Study 3). Results revealed that employees with better safety behavior showed significant ABS (Study 2), and greater ABS than employees with poorer safety behavior (Studies 1 and 2). Moreover, ABS was positively associated with the perceived safety climate and safety motivation of employees, both of which mediate the effect of ABS on safety behavior (Study 3). These results contributed to a deeper understanding of how early-stage automatic perceptual processing affects safety behavior. The practical implications of these results were also discussed. PMID:24922613

  19. An electromagnetic model for post-wall waveguide building blocks

    Microsoft Academic Search

    Teis J. Coenen; Dave J. Bekers; Joseph L. Tauritz; Frank E. van Vliet

    2010-01-01

    During the past five years, dielectric and metallic post-wall waveguides (PWWGs) have been analyzed at TNO Defence, Security and Safety, using both an integral equation approach and a modal approach. The model developed focuses on TEn0 modes facilitating the analysis of infinitely-long, straight PWWGs as well as finite PWWGs with arbitrary post positioning. Quite recently, we introduced an alternative approach

  20. Pool & Spa Safety Act

    MedlinePLUS

    ... Stories Pool Safely Home Consumer Product Safety Commission, CPSC CPSC Home The Pool & Spa Safety Act Contact Information About PoolSafely.gov and CPSC The U.S. Consumer Product Safety Commission (CPSC) is ...

  1. Medical Device Safety

    MedlinePLUS

    ... Vaccines, Blood & Biologics Animal & Veterinary Cosmetics Tobacco Products Medical Devices Print this page Share this page E-mail this page Home Medical Devices Medical Device Safety Medical Device Safety Search the Medical Device Safety Section Medical ...

  2. Paper Shredder Safety Alert

    MedlinePLUS

    Paper Shredder Safety Alert Consumer model paper shredders are very popular. The U.S. Consumer Product Safety Commission ( ... offers the following safety tips when using a paper shredder: ? Never allow children to operate paper shredders, ...

  3. Surveying Science Safety.

    ERIC Educational Resources Information Center

    Gerlovich, Jack A.; Parsa, Rahul

    2002-01-01

    Reports the results of a National Science Teachers Association (NSTA) study that analyzed science classroom safety. Examines the potential need for a national safety indexing system to rank states with regard to science safety. (DDR)

  4. ETE Electrical Safety

    NSDL National Science Digital Library

    This resource is a collection of safety topics that may be discussed in electrical safety meetings or classes. Topics include fuse removal, GFCIs, electrical shock, first aid, LOTO, PPE, fire safety, and hazardous locations.

  5. Household Safety: Preventing Drowning

    MedlinePLUS

    ... Expect Ebola: What to Know Household Safety: Preventing Drowning KidsHealth > Parents > First Aid & Safety > Home Sweet Home > Household Safety: Preventing Drowning Print A A A Text Size What's in ...

  6. Water Safety Quiz

    MedlinePLUS

    Water Safety Quiz Trivia quiz loading... Please enable javascript. Stay Safe around Water Download water safety tips in English or Spanish and share them with your friends. Make Water Safety a Priority Contact your local Red Cross ...

  7. Post-Keynesian Theory: An Overview.

    ERIC Educational Resources Information Center

    Kregel, J. A.

    1983-01-01

    The evolution and current position of post-Keynesian economic theory are examined. The theory is based on Keynes' exposition of effective demand in a monetary production economy determining the level of employment, rather than through supply and demand in the "real" and "monetary" sectors determining the level of real output. (Author/RM)

  8. [Activity and safety of fenspiride in bronchial hyperexudation (author's transl)].

    PubMed

    de Labarthe, B; Gosset, X; Dourmap, C; Delaval, P; Le Rest, R

    This clinical trial of fenspiride (injectable and sustained-release 80 mg tablet) was carried out on patients selected because their bronchopathy was of a hypersecretory type. Interesting results were observed in 20 out of 37 cases, but they were often delayed. This group of patients included a high proportion of patients with major hypersecretion; the efficacy of fenspiride is often evident, (in 8 out of 11 cases) but it is unpredictable individually. It can be concluded from this trial that a long term treatment with fenspiride, well tolerated, can usefully be tried in patients with predominant signs of bronchial hyperexudation. PMID:42144

  9. Safety analysis

    NASA Technical Reports Server (NTRS)

    Knight, John C.

    1995-01-01

    We are engaged in a research program in safety-critical computing that is based on two case studies. We use these case studies to provide application-specific details of the various research issues, and as targets for evaluation of research ideas. The first case study is the Magnetic Stereotaxis System (MSS), an investigational device for performing human neurosurgery being developed in a joint effort between the Department of Physics at the University of Virginia and the Department of Neurosurgery at the University of Iowa. The system operates by manipulating a small permanent magnet (known as a 'seed') within the brain using an externally applied magnetic field. By varying the magnitude and gradient of the external magnetic field, the seed can be moved along a non-linear path and positioned at a site requiring therapy, e.g., a tumor. The magnetic field required for movement through brain tissue is extremely high, and is generated by a set of six superconducting magnets located in a housing surrounding the patient's head. The system uses two X-ray cameras positioned at right angles to detect in real time the locations of the seed and of X-ray opaque markers affixed to the patient's skull. the X-ray images are used to locate the objects of interest in a canonical frame of reference. the second case study is the University of Virginia Research Nuclear Reactor (UVAR). It is a 2 MW thermal, concrete-walled pool reactor. The system operates using 20 to 25 plate-type fuel assemblies placed on a rectangular grid plate. There are three scramable safety rods, and one non-scramable regulating rod that can be put in automatic mode. It was originally constructed in 1959 as a 1 MW system, and it was upgraded to 2 MW in 1973. Though only a research reactor rather than a power reactor, the issues raised are significant and can be related to the problems faced by full-scale reactor systems.

  10. Nuclear criticality safety guide

    SciTech Connect

    Pruvost, N.L.; Paxton, H.C. [eds.] [eds.

    1996-09-01

    This technical reference document cites information related to nuclear criticality safety principles, experience, and practice. The document also provides general guidance for criticality safety personnel and regulators.

  11. RADIATION SAFETY TRAINING MANUAL Radiation Safety Office

    E-print Network

    Sibille, Etienne

    RADIATION SAFETY TRAINING MANUAL Radiation Safety Office 130 DeSoto Street G-7 Parran with sources of ionizing radiation are required to be instructed in the basic principles of radiation protection and the potential risks of ionizing radiation. Radiation Safety Office personnel provide

  12. Environmental Health & Safety Office of Radiological Safety

    E-print Network

    Houston, Paul L.

    safety training and submit this registration to the LSO prior to use of Class 3B or 4 lasers. A copy will be returned to the Laser Supervisor to be filed in the Laboratory Laser Safety Notebook. Both the Laser Safety Page 2 of 2 FORM LU-1 Revision 01 1/31/2012 TO BE COMPLETED BY THE LASER USER REGISTRANT I have

  13. Evaluation of Hepatitis A Vaccine in Post-Exposure Prophylaxis, The Netherlands, 2004-2012

    PubMed Central

    Whelan, Jane; Sonder, Gerard J.; Bovée, Lian; Speksnijder, Arjen; van den Hoek, Anneke

    2013-01-01

    Background The secondary attack rate of hepatitis A virus (HAV) among contacts of cases is up to 50%. Historically, contacts were offered immunoglobulin (IG, a human derived blood product) as post-exposure prophylaxis (PEP). Amid safety concerns about IG, HAV vaccine is increasingly recommended instead. Public health authorities’ recommendations differ, particularly for healthy contacts ?40 years old, where vaccine efficacy data is limited. We evaluated routine use of HAV vaccine as an alternative to immunoglobulin in PEP, in those considered at low risk of severe infection in the Netherlands. Methods Household contacts of acute HAV cases notified in Amsterdam (2004-2012) were invited ?14 days post-exposure, for baseline anti-HAV testing and PEP according to national guidelines: immunoglobulin if at risk of severe infection, or hepatitis A vaccine if healthy and at low risk (aged <30, or, 30-50 years and vaccinated <8 days post-exposure). Incidence of laboratory confirmed secondary infection in susceptible contacts was assessed 4-8 weeks post-exposure. In a vaccinated subgroup, relative risk (RR) of secondary infection with estimated using Poisson regression. Results Of 547 contacts identified, 191 were susceptible to HAV. Per-protocol, 167 (87%) were vaccinated (mean:6.7 days post-exposure, standard deviation(sd)=3.3) and 24 (13%) were given immunoglobulin (mean:9.7 days post-exposure, sd=2.8). At follow-up testing, 8/112 (7%) had a laboratory confirmed infection of whom 7 were symptomatic. All secondary infections occurred in vaccinated contacts, and half were >40 years of age. In healthy contacts vaccinated per-protocol ?8 days post-exposure, RRref. ?15 years of secondary infection in those >40 years was 12.0 (95%CI:1.3-106.7). Conclusions Timely administration of HAV vaccine in PEP was feasible and the secondary attack rate was low in those <40 years. Internationally, upper age-limits for post-exposure vaccination vary. Pending larger studies, immunoglobulin should be considered PEP of choice in people >40 years of age and those vulnerable to severe disease. PMID:24147144

  14. [Cultural safety: a concept analysis].

    PubMed

    Blanchet Garneau, Amélie; Pepin, Jacinthe

    2012-12-01

    Cultural safety is a concept that is getting more attention in scientific literature related to the cultural dimension of care. Difficulty to grasp the meaning and implications for research, education and practice is frequently raised by the authors. A concept analysis inspired by the evolutionary method of Rodgers was performed to better understand its meaning and its utility to the various fields of nursing. A systematic review of the literature was conducted in the databases CINAHL, PsycINFO, MEDLINE, EMBASE, ERIC, and Sociological Abstracts to identify literature published between 1988 and 2012 and containing the expression "cultural safety". 68 documents were analyzed. Findings included attributes, antecedents and consequences of cultural safety. The evolution of cultural safety through the various sociocultural and political contexts and application domains is also addressed. Issues related to the definition and operationalization of the concept, as well as the ability to export it out of its context of emergence, are discussed. The concept of cultural safety needs further development and a theoretical integration before reaching a conceptual clarity and effective operationalization. PMID:23409542

  15. Globalisation, Post-Fordism and Open and Distance Education.

    ERIC Educational Resources Information Center

    Evans, Terry

    1995-01-01

    Post-Fordism and globalization are interrelated contemporary features of social and economic development. Individual, social, and educational issues concerned with globalization are discussed in relation to the emerging post-Fordism forms and practices of open and distance education, and to the cross-cultural contexts involved. (Author/AEF)

  16. 77 FR 27442 - Recruitment of First Responder Network Authority Board of Directors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-10

    ...Administration Recruitment of First Responder Network Authority Board of Directors AGENCY...Board of Directors of the First Responder Network Authority (FirstNet). The Act created...interoperable public safety broadband network. The Board of Directors will be...

  17. 10 CFR 35.2024 - Records of authority and responsibilities for radiation protection programs.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...Records of authority and responsibilities for radiation protection programs. 35.2024 Section...of authority and responsibilities for radiation protection programs. (a) A...duties, and responsibilities of the Radiation Safety Officer as required by §...

  18. 10 CFR 35.2024 - Records of authority and responsibilities for radiation protection programs.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...Records of authority and responsibilities for radiation protection programs. 35.2024 Section...of authority and responsibilities for radiation protection programs. (a) A...duties, and responsibilities of the Radiation Safety Officer as required by §...

  19. 10 CFR 35.2024 - Records of authority and responsibilities for radiation protection programs.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...Records of authority and responsibilities for radiation protection programs. 35.2024 Section...of authority and responsibilities for radiation protection programs. (a) A...duties, and responsibilities of the Radiation Safety Officer as required by §...

  20. 10 CFR 35.2024 - Records of authority and responsibilities for radiation protection programs.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...Records of authority and responsibilities for radiation protection programs. 35.2024 Section...of authority and responsibilities for radiation protection programs. (a) A...duties, and responsibilities of the Radiation Safety Officer as required by §...

  1. 20 CFR 726.114 - Period of authorization as self-insurer; reauthorization.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...2011-04-01 false Period of authorization as self-insurer; reauthorization. 726...COAL MINE HEALTH AND SAFETY ACT OF 1969, AS AMENDED BLACK LUNG BENEFITS; REQUIREMENTS... § 726.114 Period of authorization as self-insurer;...

  2. 20 CFR 726.114 - Period of authorization as self-insurer; reauthorization.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...2010-04-01 false Period of authorization as self-insurer; reauthorization. 726...COAL MINE HEALTH AND SAFETY ACT OF 1969, AS AMENDED BLACK LUNG BENEFITS; REQUIREMENTS... § 726.114 Period of authorization as self-insurer;...

  3. Feasibility of Virtual Reality Augmented Cycling for Health Promotion of People Post-Stroke

    PubMed Central

    Deutsch, Judith E; Myslinski, Mary Jane; Kafri, Michal; Ranky, Richard; Sivak, Mark; Mavroidis, Constantinos; Lewis, Jeffrey A

    2013-01-01

    Background and Purpose A virtual reality (VR) augmented cycling kit (VRACK) was developed to address motor control and fitness deficits of individuals with chronic stroke. In this paper we report on the safety, feasibility and efficacy of using the VRACK to train cardio-respiratory (CR) fitness of individuals in the chronic phase poststroke. Methods Four individuals with chronic stroke (47–65 years old and three or more years post-stroke), with residual lower extremity impairments (Fugl Meyer 24–26/34) who were limited community ambulators (gait speed range 0.56 to 1.1 m/s) participated in this study. Safety was defined as the absence of adverse events. Feasibility was measured using attendance, total exercise time, and “involvement” measured with the Presence Questionnaire (PQ). Efficacy of CR fitness was evaluated using a sub-maximal bicycle ergometer test before and after an 8-week training program. Results The intervention was safe and feasible with participants having 1 adverse event, 100% adherence, achieving between 90 and 125 minutes of cycling each week and a mean PQ score of 39 (SD 3.3). There was a statistically significant 13% (p = 0.035) improvement in peak VO2 with a range of 6–24.5 %. Discussion and Conclusion For these individuals post-stroke, VR augmented cycling, using their heart rate to set their avatar’s speed, fostered training of sufficient duration and intensity to promote CR fitness. In addition, there was a transfer of training from the bicycle to walking endurance. VR augmented cycling may be an addition to the therapist’s tools for concurrent training of mobility and health promotion of individuals post-stroke. Video Abstract available (see Video, Supplemental Digital Content 1) for more insights from the authors. PMID:23863828

  4. Peculiarities of medication safety.

    PubMed

    Kvizhinadze, N; Gerzmava, O

    2013-03-01

    The modern concept of patient safe medical treatment lays responsibility for undesirable complications on lacks of healthcare system (structural, organizational and operative); not on medical workers or products of medical purpose. A spirit to comprehension of scales of a problem of a safety the sharp increase of number of judicial claims in occasion of causing harm has served health of patients. If to the beginning of 1970 th in the USA one claim on 100 doctors to 2011 frequency of supply of claims has increased in 12 times was annually registered on the average, and average payment under claims has increased for the same period about 2000 dollars up to 1500000 dollars. The problem of ensuring patient safety is topical. 72 (24%) of the 300 patients interrogated by the authors have declared that at various times were victims of inadequate rendering of medical aid. Among them of 96 (32%) have specified an establishment to them of the wrong diagnosis or purpose of wrong treatment. Results from the current study show the necessity of creation in Georgia systems of monitoring to increase the security of treatment, participation in this business of patients, creation of special preventive and training programs for the medical personnel and students, strengthening of cooperation with the international organizations in area of improvement of quality and a security of medical aid. PMID:23567310

  5. Testing safety commitment in organizations through interpretations of safety artifacts

    Microsoft Academic Search

    Gil Luria; Anat Rafaeli

    2008-01-01

    ProblemSafety culture relates to injuries and safety incidents in organizations, but is difficult to asses and measure. We describe a preliminary test of assessing an organization's safety culture by examining employee interpretations of organizational safety artifacts (safety signs).

  6. CCB Laboratory Safety Orientation Checklist Laboratory Safety Training Review

    E-print Network

    Heller, Eric

    /blood-borne pathogens, radiation safety, laser safety, liquid pyrophoric, etc...). ReviewCCB Laboratory Safety Orientation Checklist Laboratory Safety Training Review Attend CCB's Lab 300 in-class safety training. All personnel working within CCB

  7. Differentiating Post-Traumatic Stress Disorder (PTSD) from Major Depression (MDD) and Generalized Anxiety Disorder (GAD) * * An appendix for this paper is available from the authors upon request, providing a list of items, factor structure of the instrument, and authors' predictions of diagnostic class membership. It might be noted that only the list of symptoms were made available to the subjects, not the source nor our diagnostic predictions

    Microsoft Academic Search

    Terence M Keane; Kathryn L Taylor; Walter E Penk

    1997-01-01

    Questions about the differential diagnosis of Post-Traumatic Stress Disorder (PTSD) have been raised since this category was reformulated in DSM-III (APA, 1980). Clinicians have reported difficulties distinguishing PTSD from other categories, particularly from Major Depressive and Generalized Anxiety Disorders (MDD and GAD). Diagnostic validity can be established in several ways (e.g., through clinical descriptive studies, laboratory experiments, family history studies,

  8. Food safety.

    PubMed

    Borchers, Andrea; Teuber, Suzanne S; Keen, Carl L; Gershwin, M Eric

    2010-10-01

    Food can never be entirely safe. Food safety is threatened by numerous pathogens that cause a variety of foodborne diseases, algal toxins that cause mostly acute disease, and fungal toxins that may be acutely toxic but may also have chronic sequelae, such as teratogenic, immunotoxic, nephrotoxic, and estrogenic effects. Perhaps more worrisome, the industrial activities of the last century and more have resulted in massive increases in our exposure to toxic metals such as lead, cadmium, mercury, and arsenic, which now are present in the entire food chain and exhibit various toxicities. Industrial processes also released chemicals that, although banned a long time ago, persist in the environment and contaminate our food. These include organochlorine compounds, such as 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (dichlorodiphenyl dichloroethene) (DDT), other pesticides, dioxins, and dioxin-like compounds. DDT and its breakdown product dichlorophenyl dichloroethylene affect the developing male and female reproductive organs. In addition, there is increasing evidence that they exhibit neurodevelopmental toxicities in human infants and children. They share this characteristic with the dioxins and dioxin-like compounds. Other food contaminants can arise from the treatment of animals with veterinary drugs or the spraying of food crops, which may leave residues. Among the pesticides applied to food crops, the organophosphates have been the focus of much regulatory attention because there is growing evidence that they, too, affect the developing brain. Numerous chemical contaminants are formed during the processing and cooking of foods. Many of them are known or suspected carcinogens. Other food contaminants leach from the packaging or storage containers. Examples that have garnered increasing attention in recent years are phthalates, which have been shown to induce malformations in the male reproductive system in laboratory animals, and bisphenol A, which negatively affects the development of the central nervous system and the male reproductive organs. Genetically modified foods present new challenges to regulatory agencies around the world because consumer fears that the possible health risks of these foods have not been allayed. An emerging threat to food safety possibly comes from the increasing use of nanomaterials, which are already used in packaging materials, even though their toxicity remains largely unexplored. Numerous scientific groups have underscored the importance of addressing this issue and developing the necessary tools for doing so. Governmental agencies such as the US Food and Drug Administration and other agencies in the USA and their counterparts in other nations have the increasingly difficult task of monitoring the food supply for these chemicals and determining the human health risks associated with exposure to these substances. The approach taken until recently focused on one chemical at a time and one exposure route (oral, inhalational, dermal) at a time. It is increasingly recognized, however, that many of the numerous chemicals we are exposed to everyday are ubiquitous, resulting in exposure from food, water, air, dust, and soil. In addition, many of these chemicals act on the same target tissue by similar mechanisms. "Mixture toxicology" is a rapidly growing science that addresses the complex interactions between chemicals and investigates the effects of cumulative exposure to such "common mechanism groups" of chemicals. It is to be hoped that this results in a deeper understanding of the risks we face from multiple concurrent exposures and makes our food supply safer. PMID:19911313

  9. And Speaking of Authority...

    ERIC Educational Resources Information Center

    Williams, Connie

    2010-01-01

    Over breakfast at the American Library Association (ALA) Annual Conference, this author was asked, "What is authority? What does one know about the ways in which he/she determines credibility? Whom do you trust?" In this article, the author focuses on these questions in terms of administrators who have control over libraries. She provides a…

  10. Structured multimedia authoring

    Microsoft Academic Search

    Lynda Hardman; Guido van Rossum; Dick C. A. Bulterman

    1993-01-01

    We present the user interface to the CMIF authoring environment for constructing and playing multimedia presentations. The CMIF authoring environment supports a rich hypermedia document model allowing structure-based composition of multimedia presentations and the specification of synchronizati on constraints between constituent media items. An author constructs a multimedia presentation in terms of its structure and additional synchronization constraints, from which

  11. Bromine Safety

    SciTech Connect

    Meyers, B

    2001-04-09

    The production and handling in 1999 of about 200 million kilograms of bromine plus substantial derivatives thereof by Great Lakes Chemical Corp. and Albemarle Corporation in their southern Arkansas refineries gave OSHA Occupational Injury/Illness Rates (OIIR) in the range of 0.74 to 1.60 reportable OIIRs per 200,000 man hours. OIIRs for similar industries and a wide selection of other U.S. industries range from 1.6 to 23.9 in the most recent OSHA report. Occupational fatalities for the two companies in 1999 were zero compared to a range in the U.S.of zero for all computer manufacturing to 0.0445 percent for all of agriculture, forestry and fishing in the most recent OSHA report. These results show that bromine and its compounds can be considered as safe chemicals as a result of the bromine safety standards and practices at the two companies. The use of hydrobromic acid as an electrical energy storage medium in reversible PEM fuel cells is discussed. A study in 1979 of 20 megawatt halogen working fluid power plants by Oronzio de Nora Group found such energy to cost 2 to 2.5 times the prevailing base rate at that time. New conditions may reduce this relative cost. The energy storage aspect allows energy delivery at maximum demand times where the energy commands premium rates. The study also found marginal cost and performance advantages for hydrobromic acid over hydrochloric acid working fluid. Separate studies in the late 70s by General Electric also showed marginal performance advantages for hydrobromic acid.

  12. External Authorities and Peers Laboratory Ventilation Management Program

    E-print Network

    Pawlowski, Wojtek

    External Authorities and Peers Laboratory Ventilation Management Program Guidance Document External Authorities and Peers This group encompasses external groups who do not manage laboratory ventilation systems external standards for best practices and performance with regard to laboratory safety and carbon emissions

  13. 49 CFR 803.3 - Authority to affix Seal.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...2010-10-01 2010-10-01 false Authority to affix Seal. 803.3 Section 803.3 Transportation...NATIONAL TRANSPORTATION SAFETY BOARD OFFICIAL SEAL § 803.3 Authority to affix Seal. (a) The Seal shall be in the custody...

  14. Perinatal Safety: From Concept to Nursing Practice

    PubMed Central

    Kennedy, Holly Powell

    2010-01-01

    Communication and teamwork problems are leading causes of documented preventable adverse outcomes in perinatal care. An essential component of perinatal safety is the organizational culture in which clinicians work. Clinicians’ individual and collective authority to question the plan of care and take action to change the direction of a clinical situation in the patient’s best interest can be viewed as their “agency for safety.” However, collective agency for safety and commitment to support nurses in their advocacy role is missing in many perinatal care settings. This paper draws from Organizational Accident Theory, High Reliability Theory, and Symbolic Interactionism to describe the nurse’s role in maintaining safety during labor and birth in acute care settings, and suggests actions for supporting the perinatal nurse at individual, group, and systems levels to achieve maximum safety in perinatal care. PMID:20147827

  15. Safety Evaluation Report of the Waste Isolation Pilot Plant Contact Handled (CH) Waste Documented Safety Analysis

    SciTech Connect

    Washington TRU Solutions LLC

    2005-09-01

    This Safety Evaluation Report (SER) documents the Department of Energy’s (DOE's) review of Revision 9 of the Waste Isolation Pilot Plant Contact Handled (CH) Waste Documented Safety Analysis, DOE/WIPP-95-2065 (WIPP CH DSA), and provides the DOE Approval Authority with the basis for approving the document. It concludes that the safety basis documented in the WIPP CH DSA is comprehensive, correct, and commensurate with hazards associated with CH waste disposal operations. The WIPP CH DSA and associated technical safety requirements (TSRs) were developed in accordance with 10 CFR 830, Nuclear Safety Management, and DOE-STD-3009-94, Preparation Guide for U. S. Department of Energy Nonreactor Nuclear Safety Analysis Reports.

  16. Safety Standards for Projectors.

    ERIC Educational Resources Information Center

    Wyman, Raymond

    1979-01-01

    The safety of projectors and related viewing devices for school, home, and business use is of paramount importance. The Advisory Committee on Safety (ACOS) of the International Electrotechnical Commission (IEC) has established a working group to consider the problem of projector safety and to make recommendations for safety standards. (CMV)

  17. Nuclear Powerplant Safety: Operations.

    ERIC Educational Resources Information Center

    Department of Energy, Washington, DC. Nuclear Energy Office.

    Powerplant systems and procedures that ensure the day-to-day health and safety of people in and around the plant is referred to as operational safety. This safety is the result of careful planning, good engineering and design, strict licensing and regulation, and environmental monitoring. Procedures that assure operational safety at nuclear…

  18. Radiation Safety September 2013

    E-print Network

    California at Irvine, University of

    Radiation Safety Manual September 2013 Office of Environment, Health & Safety #12;RADIATION SAFETY of ionizing radiation as a valuable tool to extend fundamental knowledge. These activities are an important of radiation-producing machines and radioactive materials attests to the success of its radiation safety

  19. Radiation Safety Program Annual Review

    E-print Network

    Lyubomirsky, Ilya

    .................................................................................................3 MANAGEMENT OVERSIGHT OF THE RADIATION SAFETY/LASER SAFETY PROGRAMS .............3 LICENSE RENEWAL SAFETY/LASER SAFETY PROGRAM OVERVIEW.......................................................4 RADIATION for Radiation Producing Machines (RPM) Expires 8/31/2011 MANAGEMENT OVERSIGHT OF THE RADIATION SAFETY/LASER

  20. Author! Author! Making Kids Laugh: Jon Scieszka

    ERIC Educational Resources Information Center

    Brodie, Carolyn S.

    2004-01-01

    This article presents a brief biography of author Jon Scieszka, best known for his first published title, "The True Story of the Three Little Pigs!" which has become a modern classic. The publication of this creative and inventive title led to the numerous fractured fairy tales published since its release in 1989. His books have received numerous…

  1. Author! Author! Seymour Simon: Science Writer Extraordinaire

    ERIC Educational Resources Information Center

    Brodie, Carolyn S.

    2005-01-01

    This column presents a brief biography of author Seymour Simon, whose topics for children's photo essays include icebergs, gorillas, thunderstorms, optical illusions, snakes, air, water, planets, airplanes, volcanoes, cars, the brain, bridges, bugs, crocodiles, skyscrapers, sharks, and paper airplanes. Though he is best known in the style and an…

  2. 77 FR 36604 - Office of Hazardous Materials Safety Actions on Special Permit Applications

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-19

    ...Pipeline and Hazardous Materials Safety Administration Office of Hazardous Materials Safety Actions on Special...authorize in 178.345(2) as materials of construction and to...special permit originally and Space 173.302(a)....

  3. Launch Services Safety Overview

    NASA Technical Reports Server (NTRS)

    Loftin, Charles E.

    2008-01-01

    NASA/KSC Launch Services Division Safety (SA-D) services include: (1) Assessing the safety of the launch vehicle (2) Assessing the safety of NASA ELV spacecraft (S/C) / launch vehicle (LV) interfaces (3) Assessing the safety of spacecraft processing to ensure resource protection of: - KSC facilities - KSC VAFB facilities - KSC controlled property - Other NASA assets (4) NASA personnel safety (5) Interfacing with payload organizations to review spacecraft for adequate safety implementation and compliance for integrated activities (6) Assisting in the integration of safety activities between the payload, launch vehicle, and processing facilities

  4. The unresolved safety concerns of bovine thrombin.

    PubMed

    Shander, Aryeh; Javidroozi, Mazyar

    2008-01-01

    A recent review has suggested that bovine thrombin is not associated with an increased risk of bleeding in surgical populations. In spite of extremely limited evidence available, many valuable resources (e.g. safety surveillance and post-marketing programs, case reports) were excluded in reaching this conclusion. While waiting for the adequately powered, controlled clinical trials to address the effects of bovine thrombin on bleeding and thrombotic events, the potential risk cannot be simply ignored. Rather, continued vigilance in the post-surgical setting for bleeding events that may be associated with the development of acquired coagulation factor inhibitors following bovine thrombin administration is warranted. PMID:18808708

  5. Reactor Safety Research Programs

    SciTech Connect

    Dotson, CW

    1980-08-01

    This document summarizes the work performed by Pacific Northwest laboratory from October 1 through December 31, 1979, for the Division of Reactor Safety Research within the Nuclear Regulatory Commission. Evaluation of nondestructive examination (NDE) techniques and instrumentation are reported; areas of investigation include demonstrating the feasibilty of determining structural graphite strength, evaluating the feasibilty of detecting and analyzing flaw growth in reactor pressure boundary systems, examining NDE reliability and probabilistic fracture mechanics, and assessing the remaining integrity of pressurized water reactor steam generator tubes where service-induced degradation has been indicated. Test assemblies and analytical support are being provided for experimental programs at other facilities. These programs include the loss-of-coolant accident simulation tests at the NRU reactor, Chalk River, Canada; the fuel rod deformation and post-accident coolability tests for the ESSOR Test Reactor Program, lspra, Italy; the blowdown and reflood tests in the test facility at Cadarache, France; the instrumented fuel assembly irradiation program at Halden, Norway; and the experimental programs at the Power Burst Facility, Idaho National Engineering Laboratory. These programs will provide data for computer modeling of reactor system and fuel performance during various abnormal operating conditions.

  6. Posted 5/10/12 Manufacturing /Process Engineer

    E-print Network

    Heller, Barbara

    of lean manufacturing techniques and 80/20 is required. Responsibilities & Duties Lead process and ultimately lead to quantum leap cost reductions. Lead lean manufacturing initiatives to improve safetyPosted 5/10/12 Manufacturing /Process Engineer Plymouth Tube Co. is a specialty manufacturer

  7. The dragon's tail: Radiation safety in the Manhattan Project

    SciTech Connect

    Hacker, B.C.

    1987-01-01

    The book's contents are: Introduction: radiation safety in World War II. Foundations of Manhattan Project radiation safety. Role of the Chicago Health Division. Radiation safety at Los Alamos, Trinity. From Japan to Bikini. Crossroads. Epilogue: continuity and change in radiation safety. Appendix: chronological index of radiation exposure standards. Index. The United States Department of Energy and the Energy Research and Development Administration financially supported this book which provides a historical account of radiological safety in nuclear weapons testing during World War II. The author relied on archival sources and the oral testimony of participants and eyewitnesses. He provides a bibliography with full citations.

  8. [Research progress in post-fire debris flow].

    PubMed

    Di, Xue-ying; Tao, Yu-zhu

    2013-08-01

    The occurrence of the secondary disasters of forest fire has significant impacts on the environment quality and human health and safety. Post-fire debris flow is one of the most hazardous secondary disasters of forest fire. To understand the occurrence conditions of post-fire debris flow and to master its occurrence situation are the critical elements in post-fire hazard assessment. From the viewpoints of vegetation, precipitation threshold and debris flow material sources, this paper elaborated the impacts of forest fire on the debris flow, analyzed the geologic and geomorphic conditions, precipitation and slope condition that caused the post-fire debris flow as well as the primary mechanisms of debris-flow initiation caused by shallow landslide or surface runoff, and reviewed the research progress in the prediction and forecast of post-fire debris flow and the related control measures. In the future research, four aspects to be focused on were proposed, i. e., the quantification of the relationships between the fire behaviors and environmental factors and the post-fire debris flow, the quantitative research on the post-fire debris flow initiation and movement processes, the mechanistic model of post-fire debris flow, and the rapid and efficient control countermeasures of post-fire debris flow. PMID:24380363

  9. Patient safety goals for the proposed Federal Health Information Technology Safety Center.

    PubMed

    Sittig, Dean F; Classen, David C; Singh, Hardeep

    2014-10-20

    The Office of the National Coordinator for Health Information Technology is expected to oversee creation of a Health Information Technology (HIT) Safety Center. While its functions are still being defined, the center is envisioned as a public-private entity focusing on promotion of HIT related patient safety. We propose that the HIT Safety Center leverages its unique position to work with key administrative and policy stakeholders, healthcare organizations (HCOs), and HIT vendors to achieve four goals: (1) facilitate creation of a nationwide 'post-marketing' surveillance system to monitor HIT related safety events; (2) develop methods and governance structures to support investigation of major HIT related safety events; (3) create the infrastructure and methods needed to carry out random assessments of HIT related safety in complex HCOs; and (4) advocate for HIT safety with government and private entities. The convening ability of a federally supported HIT Safety Center could be critically important to our transformation to a safe and effective HIT enabled healthcare system. PMID:25332353

  10. Safety equipment list for the 241-SY-101 RAPID mitigation project

    SciTech Connect

    MORRIS, K.L.

    1999-06-29

    This document provides the safety classification for the safety (safety class and safety RAPID Mitigation Project. This document is being issued as the project SEL until the supporting authorization basis documentation, this document will be superseded by the TWRS SEL (LMHC 1999), documentation istlralized. Upon implementation of the authorization basis significant) structures, systems, and components (SSCS) associated with the 241-SY-1O1 which will be updated to include the information contained herein.

  11. Prediction of the response to citalopram and reboxetine in post-stroke depressed patients

    Microsoft Academic Search

    Liborio Rampello; Santina Chiechio; Giovanni Nicoletti; Alessandro Alvano; Ignazio Vecchio; Rocco Raffaele; Mariano Malaguarnera

    2004-01-01

    Rationale and objective Depression is a significant complication of stroke. The effectiveness of antidepressant drugs in the management of post-stroke depression (PSD) has been widely investigated. However, the choice of antidepressant drug is critically influenced by its safety and tolerability and by its effect on concurrent pathologies. Here we investigate the efficacy and safety of a selective serotonin reuptake inhibitor

  12. Strain balanced quantum posts

    SciTech Connect

    Alonso-Alvarez, D.; Alen, B.; Ripalda, J. M.; Llorens, J. M.; Taboada, A. G.; Briones, F. [IMM-Instituto de Microelectronica de Madrid (CNM-CSIC), Isaac Newton 8, 28760 Tres Cantos (Spain); Roldan, M. A.; Hernandez-Saz, J.; Hernandez-Maldonado, D.; Herrera, M.; Molina, S. I. [Departamento de Ciencia de los Materiales e Ing. Metalurgica y Q. I., Universidad de Cadiz, Campus Universitario de Puerto Real, 11510 Puerto Real, Cadiz (Spain)

    2011-04-25

    Quantum posts are assembled by epitaxial growth of closely spaced quantum dot layers, modulating the composition of a semiconductor alloy, typically InGaAs. In contrast with most self-assembled nanostructures, the height of quantum posts can be controlled with nanometer precision, up to a maximum value limited by the accumulated stress due to the lattice mismatch. Here, we present a strain compensation technique based on the controlled incorporation of phosphorous, which substantially increases the maximum attainable quantum post height. The luminescence from the resulting nanostructures presents giant linear polarization anisotropy.

  13. TWRS safety program plan

    SciTech Connect

    Calderon, L.M., Westinghouse Hanford

    1996-08-01

    Management of Nuclear Safety, Industrial Safety, Industrial Hygiene, and Fire Protection programs, functions, and field support resources for Tank Waste Remediation Systems (TWRS) has, until recently, been centralized in TWRS Safety, under the Emergency, Safety, and Quality organization. Industrial hygiene technician services were also provided to support operational needs related to safety basis compliance. Due to WHC decentralization of safety and reengineering efforts in West Tank Farms, staffing and safety responsibilities have been transferred to the facilities. Under the new structure, safety personnel for TWRS are assigned directly to East Tank Farms, West Tank Farms, and a core Safety Group in TWRS Engineering. The Characterization Project Operations (CPO) safety organization will remain in tact as it currently exists. Personnel assigned to East Tank Farms, West Tank Farms, and CPO will perform facility-specific or project-specific duties and provide field implementation of programs. Those assigned to the core group will focus on activities having a TWRS-wide or programmatic focus. Hanford-wide activities will be the responsibility of the Safety Center of Expertise. In order to ensure an effective and consistent safety program for TWRS under the new organization program functions, goals, organizational structure, roles, responsibilities, and path forward must be clearly established. The purpose of the TWRS Safety Program Plan is to define the overall safety program, responsibilities, relationships, and communication linkages for safety personnel under the new structure. In addition, issues associated with reorganization transition are addressed, including training, project ownership, records management, and dissemination of equipment. For the purpose of this document ``TWRS Safety`` refers to all safety professionals and technicians (Industrial Safety, Industrial Hygiene, Fire Protection, and Nuclear Safety) within the TWRS organization, regardless of their location in the organization.

  14. UTSI Safety Manual Reference to corresponding UT System Safety Policies

    E-print Network

    Davis, Lloyd M.

    Safety SA0500 Laser Safety SA0600 Reporting Safety and Health Concerns SA0700 Safety and Environmental1 UTSI Safety Manual Reference to corresponding UT System Safety Policies: www.utk.edu/administration/ Under OFFICE MANAGEMENT, link to Safety under Policies and Procedures On the left side, link

  15. Post-Exposure Prophylaxis

    MedlinePLUS

    ... exposure. It is not a substitute for other proven HIV prevention methods, such as correct and consistent ... â?? HIV in Healthcare Settings CDC â?? Proven HIV Prevention Methods Occupational Safety & Health Administration (OSHA) ...

  16. Authoring tool evaluation

    SciTech Connect

    Wilson, A.L.; Klenk, K.S.; Coday, A.C.; McGee, J.P.; Rivenburgh, R.R.; Gonzales, D.M.; Mniszewski, S.M.

    1994-09-15

    This paper discusses and evaluates a number of authoring tools currently on the market. The tools evaluated are Visix Galaxy, NeuronData Open Interface Elements, Sybase Gain Momentum, XVT Power++, Aimtech IconAuthor, Liant C++/Views, and Inmark Technology zApp. Also discussed is the LIST project and how this evaluation is being used to fit an authoring tool to the project.

  17. Twentieth-century Authors

    NSDL National Science Digital Library

    College and Research Library News has posted this new annotated directory to aid students and researchers working with English literature of the twentieth century. This site focuses on major English-language writers, offering mainly "biographical and bibliographic information, with some information on literary criticism."

  18. POSITION POSTING Liaison Librarian

    E-print Network

    Kambhampati, Patanjali

    POSITION POSTING Liaison Librarian Humanities and Social Sciences Library Assistant Librarian (nonGill Library seeks an innovative, autonomous and resourceful librarian to assist in the provision of a range

  19. Post-Adolescent Issues

    MedlinePLUS

    COPING & HEALING CARING FOR A CHILD: POST-ADOLESCENT ISSUES As your child reaches adulthood, there will be different issues and considerations to contend with. These may include restrictions on choice of ...

  20. Revealing and Resolving Patient Safety Defects: The Impact of Leadership WalkRounds on Frontline Caregiver Assessments of Patient Safety

    PubMed Central

    Frankel, Allan; Grillo, Sarah Pratt; Pittman, Mary; Thomas, Eric J; Horowitz, Lisa; Page, Martha; Sexton, Bryan

    2008-01-01

    Objective To evaluate the impact of rigorous WalkRounds on frontline caregiver assessments of safety climate, and to clarify the steps and implementation of rigorous WalkRounds. Data Sources/Study Setting Primary outcome variables were baseline and post WalkRounds safety climate scores from the Safety Attitudes Questionnaire (SAQ). Secondary outcomes were safety issues elicited through WalkRounds. Study period was August 2002 to April 2005; seven hospitals in Massachusetts agreed to participate; and the project was implemented in all patient care areas. Study Design Prospective study of the impact of rigorously applied WalkRounds on frontline caregivers assessments of safety climate in their patient care area. WalkRounds were conducted weekly and according to the seven-step WalkRounds Guide. The SAQ was administered at baseline and approximately 18 months post-WalkRounds implementation to all caregivers in patient care areas. Results Two of seven hospitals complied with the rigorous WalkRounds approach; hospital A was an academic teaching center and hospital B a community teaching hospital. Of 21 patient care areas, SAQ surveys were received from 62 percent of respondents at baseline and 60 percent post WalkRounds. At baseline, 10 of 21 care areas (48 percent) had safety climate scores below 60 percent, whereas post-WalkRounds three care areas (14 percent) had safety climate scores below 60 percent without improving by 10 points or more. Safety climate scale scores in hospital A were 62 percent at baseline and 77 percent post-WalkRounds (t=2.67, p=.03), and in hospital B were 46 percent at baseline and 56 percent post WalkRounds (t=2.06, p=.06). Main safety issues by category were equipment/facility (A [26 percent] and B [33 percent]) and communication (A [24 percent] and B [18 percent]). Conclusions WalkRounds implementation requires significant organizational will; sustainability requires outstanding project management and leadership engagement. In the patient care areas that rigorously implemented WalkRounds, frontline caregiver assessments of patient safety increased. SAQ results such as safety climate scores facilitate the triage of quality improvement efforts, and provide consensus assessments of frontline caregivers that identify themes for improvement. PMID:18671751

  1. Post Hyphen Blank: Poetic Canon in an Age of Genre-Fragging.

    ERIC Educational Resources Information Center

    Clark, Ross

    2002-01-01

    Considers how in "Post-Something" times, misquotation has become a reading practice, or at least a strategy within certain practices of reading. Suggests that Post-Modernism needs a canon, a continuity of culture, in order to be Post-Anything. Describes how in making his own canon, the author posits certain genre qualities that appeal to him, and…

  2. Authoring and Hypermedia.

    ERIC Educational Resources Information Center

    Lieberth, Ann K.; Martin, Doug R.

    1995-01-01

    Because of the diversity of clients served by speech-language pathologists and audiologists, available commercial software may not meet all needs. Authoring programs allow the clinician to design software that can be customized for individual clients. This article describes an authoring program called HyperCard and its use in preparing hypermedia…

  3. Boerhaave: Author and Editor *

    PubMed Central

    Lindeboom, G. A.

    1974-01-01

    The many facets of Herman Boerhaave's life are presented. He was a renowned teacher, physician, author, and editor. Discussed here are his activities as cataloger of the Vossius Collection, author of books on chemistry, botany, and medicine, and as editor of works by Vesalius and early Greek medical writers. Printing and bookselling in Leiden during Boerhaave's era are described. Images PMID:4596962

  4. Question the Author

    NSDL National Science Digital Library

    2012-05-16

    This web page describes the comprehension strategy of Question the Author (QtA), a strategy in which students pose questions while reading nonfiction text. Students pose questions about the author's purpose in including certain phrases or forms of information while reading. Sample questions are provided in a three-step instructional sequence. References are included.

  5. Charter Authorizers Face Challenges

    ERIC Educational Resources Information Center

    Gustafson, Joey

    2013-01-01

    Since the first charter school opened 20 years ago in Minnesota, charters have been a focus of school reform advocates and the subject of substantial research. Yet the regulators of the charter industry (called "authorizers" or "sponsors") remain a mystery to many. In fact, many authorizers work in isolation, developing their…

  6. Evaluating Digital Authoring Tools

    ERIC Educational Resources Information Center

    Wilde, Russ

    2004-01-01

    As the quality of authoring software increases, online course developers become less reliant on proprietary learning management systems, and develop skills in the design of original, in-house materials and the delivery platforms for them. This report examines the capabilities of digital authoring software tools for the development of learning…

  7. SNTP environmental, safety, and health

    NASA Technical Reports Server (NTRS)

    Harmon, Charles D.

    1993-01-01

    Viewgraphs on space nuclear thermal propulsion (SNTP) environmental, safety, and health are presented. Topics covered include: program safety policy; program safety policies; and DEIS public hearing comments.

  8. Occupational Health and Safety Manual

    E-print Network

    Occupational Health and Safety Manual #12;1 Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 York University Occupational Health and Safety Policy and Programs. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Occupational Health and Safety Legislation

  9. Chemical Hygiene and Safety Plan

    E-print Network

    Ricks Editor, R.

    2009-01-01

    Respirator Use • Laser Safety • Forklift Safety • Incidentallasers, microwave sources, radioactive CORROSIVE ELECTRICAL WEAR SAFETYLASER BEAM - IN BLACK LETTERS ON YELLOW FIELD, EMED CO. EA SIGN, SAFETY,

  10. Traffic Safety Culture Center for Transportation Safety

    E-print Network

    respondents believe that texting while driving (85 percent) and cell phone use (81 percent) have become bigger in Texas is 34 percent. Supporters of a law to ban cell phone use while driving outnumber opponentsThe Texas Traffic Safety Culture Survey Center for Transportation Safety November 2010

  11. Magnetic Field Safety Magnetic Field Safety

    E-print Network

    McQuade, D. Tyler

    Magnetic Field Safety Training #12;Magnetic Field Safety Strong Magnetic Fields exist around energized magnets. High magnetic fields alone are a recognized hazard only for personnel with certain medical conditions such as pacemakers, magnetic implants, or embedded shrapnel. In addition, high magnetic

  12. Team Performance and Space Safety

    NASA Astrophysics Data System (ADS)

    Kanki, B. G.; Rogers, D. G.; Bessone, L.; Parke, B.; Sandal, G. M.; Whiteley, I.

    This paper discusses how space safety is influenced by the ability of teams to work and communicate effectively together. A multi-national team of six authors provides different perspectives on human systems, from both research and operational points of view. When operations involve teams whose members cross organizational and cultural boundaries as they do in current space operations, it is especially critical and challenging to facilitate the most effective team performance. Three key factors that affect team performance and space safety are discussed: (1) communication as related to team performance; (2) the influence of organizations, teams and culture and (3) team training interventions. Relevant research and current practices are described for each of the three areas and a summary in the form of recommendations is provided.

  13. Hazmat Safety Community

    NSDL National Science Digital Library

    US Department of Transportation (US Department of Transportation)

    2012-01-05

    This website created by the US Department of Transportation Pipeline and Hazardous Materials Safety Administration, provides information on hazardous materials, regulations, safety advisory notices, training, as well as additional information.

  14. Spacecraft Fire Safety

    NASA Technical Reports Server (NTRS)

    Margle, Janice M. (editor)

    1987-01-01

    Fire detection, fire standards and testing, fire extinguishment, inerting and atmospheres, fire-related medical science, aircraft fire safety, Space Station safety concerns, microgravity combustion, spacecraft material flammability testing, and metal combustion are among the topics considered.

  15. Gun Safety Tips

    MedlinePLUS

    ... You are here Home > Safety Tips > Tip > Guns Gun Safety Tips Store Guns and Ammunition Safely Store ... visit about safe gun storage practices. Dispose of Guns You Don't Need If you decide that ...

  16. Aviation safety analysis

    E-print Network

    Ausrotas, Raymond A.

    1984-01-01

    Introduction: Just as the aviation system is complex and interrelated, so is aviation safety. Aviation safety involves design of aircraft and airports, training of ground personnel and flight crew members' maintenance of ...

  17. National Safety Council

    MedlinePLUS

    ... Collaborating. ? making our world safer ® ? National Window Safety Week is April 5-11 NSC and the window ... educates caregivers through initiatives like National Window Safety Week. Get the Facts Be Ready for an OSHA ...

  18. Safety behaviour: a reconsideration.

    PubMed

    Rachman, S; Radomsky, Adam S; Shafran, Roz

    2008-02-01

    There is ample evidence that the use of safety behaviour can interfere with the progress of therapy, particularly if exposure is involved. As a result, it is widely asserted that safety behaviour is anti-therapeutic. However, an unqualified rejection of safety behaviour should be reconsidered because we now have theoretical justification, experimental evidence and clinical observations showing that the judicious use of safety behaviour, especially in the early stages of treatment, can be facilitative. Experiments in which escape behaviour facilitated fear reduction, and others in which the use of safety gear facilitated fear reduction, are reviewed. It also appears that safety behaviour does not necessarily prevent disconfirmatory experiences. We propose that additional investigations of the judicious use of safety behaviour will help to elucidate therapeutic uses of safety behaviour in the treatment of anxious and related types of psychopathology. PMID:18199423

  19. Household Safety: Button Batteries

    MedlinePLUS

    ... Expect Ebola: What to Know Household Safety: Button Batteries KidsHealth > Parents > First Aid & Safety > Home Sweet Home > ... child swallows one. These guidelines can help. Safe Battery Storage & Use Store all unused batteries out of ...

  20. Facility safety study

    NASA Technical Reports Server (NTRS)

    1979-01-01

    The safety of NASA's in house microelectronics facility is addressed. Industrial health standards, facility emission control requirements, operation and safety checklists, and the disposal of epitaxial vent gas are considered.

  1. Water safety and drowning

    MedlinePLUS

    ... among people of all ages. Learning and practicing water safety is important to prevent drowning accidents. ... Water safety tips for all ages include: Learn CPR. Never swim alone. Never dive into water unless ...

  2. The TRIPOD e-learning Platform for the Training of Earthquake Safety Assessment

    SciTech Connect

    Coppari, S.; Di Pasquale, G.; Goretti, A.; Papa, F.; Papa, S.; Paoli, G.; Pizza, A. G.; Severino, M. [Italian Department of Civil Protection, Via Vitorchiano 2, 00189, Rome (Italy)

    2008-07-08

    The paper summarizes the results of the in progress EU Project titled TRIPOD (Training Civil Engineers on Post-Earthquake Safety Assessment of Damaged Buildings), funded under the Leonardo Da Vinci program. The main theme of the project is the development of a methodology and a learning platform for the training of technicians involved in post-earthquake building safety inspections. In the event of a catastrophic earthquake, emergency building inspections constitute a major undertaking with severe social impact. Given the inevitable chaotic conditions and the urgent need of a great number of specialized individuals to carry out inspections, past experience indicates that inspection teams are often formed in an adhoc manner, under stressful conditions, at a varying levels of technical expertise and experience, sometime impairing the reliability and consistency of the inspection results. Furthermore each Country has its own building damage and safety assessment methodology, developed according to its experience, laws, building technology and seismicity. This holds also for the partners participating to the project (Greece, Italy, Turkey, Cyprus), that all come from seismically sensitive Mediterranean countries. The project aims at alleviating the above shortcomings by designing and developing a training methodology and e-platform, forming a complete training program targeted at inspection engineers, specialized personnel and civil protection agencies. The e-learning platform will provide flexible and friendly authoring mechanisms, self-teaching and assessment capabilities, course and trainee management, etc. Courses will be also made available as stand-alone multimedia applications on CD and in the form of a complete pocket handbook. Moreover the project will offer the possibility of upgrading different experiences and practices: a first step towards the harmonization of methodologies and tools of different Countries sharing similar problems. Finally, through wide dissemination activities, the final aim of the project is to ensure the deployment and the integration into existing earthquake mitigation policies and vocational training schemes.

  3. Biologic safety in psoriasis: review of long-term safety data.

    PubMed

    Mansouri, Yasaman; Goldenberg, Gary

    2015-02-01

    The development of targeted biologic agents has revolutionized the treatment of psoriasis. In this review, the authors focus on the published long-term (? one year) safety data for the use of tumor necrosis factor-? antagonists etanercept, infliximab, and adalimumab, as well as the IL-12/IL-23 antagonist ustekinumab, in adult patients with moderate-to-severe psoriasis. The efficacy of these currently available biologic therapies has been demonstrated in several studies, and their safety profiles are also reassuring. PMID:25741401

  4. Multilingualism in Post-Soviet Countries: Language Revival, Language Removal, and Sociolinguistic Theory

    ERIC Educational Resources Information Center

    Pavlenko, Aneta

    2008-01-01

    Since the post-Soviet context is not particularly well known to the majority of readers, the author uses this introduction to provide a general background against which developments in particular post-Soviet countries can be better understood. The author begins by placing these developments in the sociohistoric context of language policies of the…

  5. Policy #3012 Safety and Security Policy 1 OLD DOMINION UNIVERSITY

    E-print Network

    , and supports institutional purposes (such as a food or other retail vendor). Campus Security AuthorityPolicy #3012 ­ Safety and Security Policy 1 OLD DOMINION UNIVERSITY University Policy Policy #3012 SAFETY AND SECURITY POLICY Responsible Oversight Executive: Chief Operating Officer Date of Current

  6. Air Quality: Implementation Plan Department: Chemical and General Safety

    E-print Network

    Wechsler, Risa H.

    Air Quality: Implementation Plan Department: Chemical and General Safety Program: Air Quality Owner: Program Manager Authority: ES&H Manual, Chapter 30, Air Quality1 The requirements of Chapter 30, "Air in place 1 SLAC Environment, Safety, and Health Manual (SLAC-I-720-0A29Z-001), Chapter 30, "Air Quality

  7. Generic safety documentation model

    SciTech Connect

    Mahn, J.A.

    1994-04-01

    This document is intended to be a resource for preparers of safety documentation for Sandia National Laboratories, New Mexico facilities. It provides standardized discussions of some topics that are generic to most, if not all, Sandia/NM facilities safety documents. The material provides a ``core`` upon which to develop facility-specific safety documentation. The use of the information in this document will reduce the cost of safety document preparation and improve consistency of information.

  8. DOE handbook electrical safety

    SciTech Connect

    NONE

    1998-01-01

    Electrical Safety Handbook presents the Department of Energy (DOE) safety standards for DOE field offices or facilities involved in the use of electrical energy. It has been prepared to provide a uniform set of electrical safety guidance and information for DOE installations to effect a reduction or elimination of risks associated with the use of electrical energy. The objectives of this handbook are to enhance electrical safety awareness and mitigate electrical hazards to employees, the public, and the environment.

  9. Electrical safety guidelines

    SciTech Connect

    Not Available

    1993-09-01

    The Electrical Safety Guidelines prescribes the DOE safety standards for DOE field offices or facilities involved in the use of electrical energy. It has been prepared to provide a uniform set of electrical safety standards and guidance for DOE installations in order to affect a reduction or elimination of risks associated with the use of electrical energy. The objectives of these guidelines are to enhance electrical safety awareness and mitigate electrical hazards to employees, the public, and the environment.

  10. Aviation Safety Issues Database

    NASA Technical Reports Server (NTRS)

    Morello, Samuel A.; Ricks, Wendell R.

    2009-01-01

    The aviation safety issues database was instrumental in the refinement and substantiation of the National Aviation Safety Strategic Plan (NASSP). The issues database is a comprehensive set of issues from an extremely broad base of aviation functions, personnel, and vehicle categories, both nationally and internationally. Several aviation safety stakeholders such as the Commercial Aviation Safety Team (CAST) have already used the database. This broader interest was the genesis to making the database publically accessible and writing this report.

  11. Safety analysts training

    SciTech Connect

    Bolton, P.

    2000-10-01

    The purpose of this task was to support ESH-3 in providing Airborne Release Fraction and Respirable Fraction training to safety analysts at LANL who perform accident analysis, hazard analysis, safety analysis, and/or risk assessments at nuclear facilities. The task included preparation of materials for and the conduct of two 3-day training courses covering the following topics: safety analysis process; calculation model; aerosol physic concepts for safety analysis; and overview of empirically derived airborne release fractions and respirable fractions.

  12. Agriscience Shop Safety

    NSDL National Science Digital Library

    Mr. Creel

    2011-11-02

    After completing this project, you should be able to pass the Shop Safety Test, allowing you to participate in the Agriscience Shop. Before you are allowed into the shop, you are required to pass a Shop Safety Test. The tools that follow will help you prepare for the test. Use the Shop Safety Chart that Mr. Creel gave you in class to take notes on important safety rules. OSHA is the "governmental ...

  13. Library of Congress Authorities

    NSDL National Science Digital Library

    A handy tool for librarians, Library of Congress (LC) Authorities is a new feature that allows users the opportunity to better access LC authority data via the Internet. Downloadable in MARC format, users can browse authority headings by subject, name, title, or name/ title indexes. In order to ensure optimum system performance for public users and staff, LC has limited external simultaneous access to the database between the hours of 10 AM and 2 PM (ET), Monday through Friday. However, they are working to improve their system in order to increase the number of simultaneous users. Currently, this service is being offered on a trial basis in order to assess its usefulness.

  14. Annotating Sanskrit Corpus: Adapting IL-POSTS

    Microsoft Academic Search

    Girish Nath Jha; Madhav Gopal; Diwakar Mishra

    2009-01-01

    \\u000a In this paper we present an experiment on the use of the hierarchical Indic Languages POS\\u000a Tagset (IL-POSTS) (Baskaran et al 2008 a&b), developed by Microsoft Research India (MSRI) for tagging Indian languages, for\\u000a annotating Sanskrit corpus. Sanskrit is a language with richer morphology and relatively free word-order. The authors have\\u000a included and excluded certain tags according to the requirements

  15. Health, Safety & Wellbeing Policy

    E-print Network

    Mottram, Nigel

    Health, Safety & Wellbeing Policy Statement The University of Glasgow is one of the four oldest our very best to minimise the risk to the health, safety and wellbeing of staff, students, researchers resource and our students as our valued customers and partners. We acknowledge health and safety as a core

  16. Annual Fire Safety Report

    E-print Network

    Loudon, Catherine

    2010 Annual Fire Safety Report University of California, Irvine HIGHER EDUCATION OPPORTUNITY to the Fire Safety in Student Housing Buildings of current or perspective students and employees be reported INTRODUCTION Fire Safety is an essential tool in protecting a campus community from injuries, deaths, business

  17. Fire Safety January 2011

    E-print Network

    Lennard, William N.

    1 Fire Safety PROCEDURES January 2011 firesafety@uwo.ca Campus Phones ­ EMERGENCY ­ Dial 911 Fire Safety Service is the focal point for the coordinated administration of the University Fire Safety program and plans, and is the University's representative in contacts dealing with all aspects of Fire

  18. Situational awareness and safety

    Microsoft Academic Search

    N. A Stanton; P. R. G Chambers; J Piggott

    2001-01-01

    This paper considers the applicability of situation awareness concepts to safety in the control of complex systems. Much of the research to date has been conducted in aviation, which has obvious safety implications. It is argued that the concepts could be extended to other safety critical domains. The paper presents three theories of situational awareness: the three-level model, the interactive

  19. Revitalizing Nuclear Safety Research.

    ERIC Educational Resources Information Center

    National Academy of Sciences - National Research Council, Washington, DC.

    This report covers the general issues involved in nuclear safety research and points out the areas needing detailed consideration. Topics included are: (1) "Principles of Nuclear Safety Research" (examining who should fund, who should conduct, and who should set the agenda for nuclear safety research); (2) "Elements of a Future Agenda for Nuclear…

  20. EHS Online Safety Training

    NSDL National Science Digital Library

    This page from Oklahoma State University provides access to a number of occupational safety modules. All modules are available to view online, and some include PowerPoint or Microsoft Word documents as well. Topics include electrical safety, lockout/tagout, safety data sheets, asbestos and bloodborne pathogens.

  1. Earth Sciences Safety Handbook

    E-print Network

    Cambridge, University of

    - 14 Lasers 25 Lifts 15 Manual Handling 23 No Smoking Policy 2 Office Safety and Use of Computer Heads of SectionsRadiation Protection Supervisors Laser Safety Officer Fire Managers (both sitesEarth Sciences Safety Handbook October 2012 Web version - updated Oct 12 #12;1 CONTENTS SUBJECT

  2. Earth Sciences Safety Handbook

    E-print Network

    Cambridge, University of

    - 14 Lasers 25 Lifts 15 Manual Handling 23 No Smoking Policy 2 Office Safety and Use of Computer Heads of SectionsRadiation Protection Supervisors Laser Safety Officer Fire Managers (both sitesEarth Sciences Safety Handbook October 2013 Web version - updated Oct 13 #12;1 CONTENTS SUBJECT

  3. LASER SAFETY Valrie REITA

    E-print Network

    Canet, Léonie

    LASER SAFETY Valérie REITA Pôle Optique Juillet 2009Juillet 2009 www.neel.cnrs.fr #12.90% Courtesy of: Rockwell Laser Industries ­ Industrial Laser Safety 1999 www.neel.cnrs.fr #12;Minimal Reactive of: Rockwell Laser Industries ­ Industrial Laser Safety 1999 #12;Summary of Basic Laser Biological

  4. Deriving and applying generally applicable safety principles

    SciTech Connect

    Spray, S.D.

    1998-08-01

    The nuclear detonation safety of modern nuclear weapons depends on a coordinated safety theme incorporating three general safety principles: isolation, inoperability, and incompatibility. The success of this approach has encouraged them to study whether these and/or other principles might be useful in other applications. Not surprisingly, no additional first-principles (based on physical laws) have been identified. However, a more widely applicable definition and application of the principle-based approach has been developed, resulting in a selection of strategies that are basically subsets and varied combinations of the more general principles above. However, identification of principles to be relied on is only one step in providing a safe design. As one other important example, coordinating overall architecture and strategy is essential: the authors term this a safety theme.

  5. Fifty years of progress in reactor safety

    SciTech Connect

    Okrent, D. (Univ. of California, Los Angeles (United States))

    1992-01-01

    This paper chronicles the major watershed occurrences in the evaluation of current reactor safety principles and concepts. The author covers such issues as the development of siting criteria in the early 1960s, development and design of engineered safety features and emergency cooling systems (ECCS), core meltdown scenarios, anticipated transients without scram (ATWS) issues, WASH-1400 Reactor Safety study employing probabilistic risk assessment (PRA) approaches, early PRAs conducted, development of safety goals in the 1980s, and reliability of AC power. Perhaps three of the most significant events related to operating reactors that occurred near the end of the 50-yr period were recognition of the problems of aging, completion of the NUREG-1150 study, and the development of a program on severe accident management.

  6. Safe Operating Procedure SAFETY PROTOCOL: Rb-86

    E-print Network

    Farritor, Shane

    of hazardous and/or radioactive wastes are to be followed. Rb- 86 waste should be segregated from all other://ehs.unl.edu/) Use of radioactive materials requires prior approval by the UNL Radiation Safety Committee (RSC). To obtain RSC approval: · Submit an Authorization for Radioactive Material Use request for approval

  7. US Nuclear Weapon Safety and Control

    Microsoft Academic Search

    Grant Elliott

    To appreciate the public's fascination with nuclear weapon safety, one must look no further than the cinema. In Kubrick's classic Dr. Strangelove or How I Learned to Stop Worrying and Love the Bomb, a deranged US o- cer succeeds in launching a nuclear attack on the Soviet Union without authorization. Countless other films place stolen nuclear weapons in the hands

  8. An Essay: The Culture of Safety.

    ERIC Educational Resources Information Center

    Watters, Ron

    Any outdoor educator knows about rules. Outdoor educators spend a considerable amount of time at conferences talking about them: risk management plans, accepted safety practices, and first aid protocols. You name it, they've got a rule. When a Buddhist friend asked if rules really made programs safer, the author's first response was yes. His…

  9. Safety Research and Outreach IN THIS ISSUE

    E-print Network

    , according to the study. Glass bead products are frequently used for highway safety markings such as these Line Pavement Markings," was sponsored by the American Glass Bead Manufacturers' Association. "This Carlson, a TTI Research Engineer and one of the authors of the study. "Previous studies over the last 10

  10. Traceability, food safety and industry reputation

    E-print Network

    California at Davis, University of

    Traceability, food safety and industry reputation S´ebastien Pouliot Daniel A. Sumner August 25, 2009 Abstract Sometimes authorities are unable to identify the origin of a tainted food product. In such cases, food recalls or warnings are often applied to all suppliers which means that the recall applies

  11. How Can We Improve School Safety Research?

    ERIC Educational Resources Information Center

    Astor, Ron Avi; Guerra, Nancy; Van Acker, Richard

    2010-01-01

    The authors of this article consider how education researchers can improve school violence and school safety research by (a) examining gaps in theoretical, conceptual, and basic research on the phenomena of school violence; (b) reviewing key issues in the design and evaluation of evidence-based practices to prevent school violence; and (c)…

  12. Authorized quantum computation

    E-print Network

    Yu Tanaka; Mio Murao

    2009-03-12

    We present authorized quantum computation, where only a user with a non-cloneable quantum authorization key can perform a unitary operation created by an authenticated programmer. The security of our authorized quantum computation is based on the quantum computational complexity problem of forging the keys from an obfuscated quantum gate sequence. Under the assumption of the existence of a \\textit{sufficiently-random gate shuffling algorithm}, the problem is shown to be in the NQP (Non-deterministic Quantum Polynomial)-hard class by reducing it to a NQP-Complete problem, the exact non-identity check problem. Therefore, our authorized quantum computation can be computationally secure against attacks using quantum computers.

  13. Design Editorial First Author

    E-print Network

    Papalambros, Panos

    and his second. It did not occur to me to ask him: I had just written the paper myself and I had added his. The ASME Ethics guidelines to authors state the following: "To protect the integrity of authorship, only

  14. Today's Authors, Tomorrow's Scientists

    NSDL National Science Digital Library

    Diana Porter

    2009-10-01

    Although not all teachers can invite scientists into classrooms on a regular basis, they can invite them into their students' worlds through literature. Here the author shares how she used the nonfiction selection, Science to the Rescue (Markle 1

  15. Department Of Public Safety Annual Security & Fire Safety Report

    E-print Network

    Rusu, Adrian

    center, emergency medical services, safety programs and education, HAZMAT response, fire safety, alarmDepartment Of Public Safety Annual Security & Fire Safety Report 2011 In compliance with the Jeanne Safety. I encourage you to visit our web page, http://www.rowan.edu/safety browse through its sections

  16. Safety Criteria and Safety Lifecycle for Artificial Neural Networks

    E-print Network

    Kelly, Tim

    Safety Criteria and Safety Lifecycle for Artificial Neural Networks Zeshan Kurd, Tim Kelly and Jim performance based techniques that aim to improve the safety of neural networks for safety critical for safety assurance. As a result, neural networks are typically restricted to advisory roles in safety

  17. SEAS Safety Program SEAS SAFETY PROGRAM 2012-2103

    E-print Network

    Streeto · Biosafety Manager: Sid Paula · Laser Safety Officer: Xiaowei Yan · Radiation Safety: StephenSEAS Safety Program SEAS SAFETY PROGRAM 2012-2103 Program Structure and Responsibilities Dr. Anas Chalah #12;SEAS Safety Program SEAS Safety Program Structure We have developed a great model

  18. Methodological innovations expand the safety pharmacology horizon.

    PubMed

    Pugsley, M K; Curtis, M J

    2012-09-01

    Almost uniquely in pharmacology, drug safety assessment is driven by the need for elaboration and validation of methods for detecting drug actions. This is the 9th consecutive year that the Journal of Pharmacological and Toxicological Methods (JPTM) has published themed issues arising from the annual meeting of the Safety Pharmacology Society (SPS). The SPS is now past its 10th year as a distinct (from pharmacology to toxicology) discipline that integrates safety pharmacologists from industry with those in academia and the various global regulatory authorities. The themes of the 2011 meeting were (i) the bridging of safety assessment of a new chemical entity (NCE) between all the parties involved, (ii) applied technologies and (iii) translation. This issue of JPTM reflects these themes. The content is informed by the regulatory guidance documents (S7A and S7B) that apply prior to first in human (FIH) studies, which emphasize the importance of seeking model validation. The manuscripts encompass a broad spectrum of safety pharmacology topics including application of state-of-the-art techniques for study conduct and data processing and evaluation. This includes some exciting novel integrated core battery study designs, refinements in hemodynamic assessment, arrhythmia analysis algorithms, and additionally an overview of safety immunopharmacology, and a brief survey discussing similarities and differences in business models that pharmaceutical companies employ in safety pharmacology, together with SPS recommendations on 'best practice' for the conduct of a non-clinical cardiovascular assessment of a NCE. PMID:22617368

  19. Safety Assessment of Low- and Intermediate-Level Waste Disposal at Vaalputs, South Africa

    NASA Astrophysics Data System (ADS)

    Kozak, M. W.; Beyleveld, C.; Carolissen, A.

    2006-12-01

    The South African Nuclear Energy Corporation (Necsa ) owns and operates the Vaalputs radioactive waste disposal site, which is South Africa's designated facility for the disposal of low-and intermediate level radioactive waste (LILW). The bulk of the currently authorized LILW disposal at Vaalputs was generated at the Koeberg Nuclear Power Station (KNPS) near Cape Town. However, Necsa has generated wastes associated with research and uranium enrichment that are currently in storage, which are intended for disposal at Vaalputs. In addition, South Africa is currently considering expansion of its nuclear power generating capabilities, both through construction of a second pressurized water reactor (PWR) and through the development of the Pebble Bed Modular Reactor (PBMR) design. The proposed change in waste characteristics warrants a safety review of the Vaalputs authorization for the disposal of LILW. As part of the safety review, an updated postclosure safety assessment is being conducted. This current safety assessment is being conducted according to an internationally accepted state-of-the-art safety assessment methodology (IAEA, 2004), and is defensible, transparent, and credible. A formal scenario-generation methodology is being applied, which has led to the identification of a number of site-specific scenarios for further consideration. Specific features of the site, the disposal facility design, and local behavior patterns were used to screen Features, Events, and Processes (FEPs) from consideration. Specific FEPs were chosen as initiating FEPs for scenarios to be considered in the safety assessment, based on a combination of reasonable likelihood and high consequence for the analysis. Scenarios identified by this process are A nominal scenario represents the intended design basis for the long-term function of the repository. A late-subsidence scenario is included, in which subsidence occurs after active institutional control measures cease, such that mitigation measures are not conducted. The effects of long-term climate change are considered. The potential for seismically induced geological changes is considered, but is not being actively evaluated during this iteration of the safety assessment. Drilling intrusion and post-intrusion resident scenarios are included. Conceptual models to represent the behavior of the repository under these scenarios have been implemented. A characteristic feature of the Vaalputs repository is its extreme aridity. Observations at the site suggest that recharge at the site is extremely low, and that the predominant moisture movement is upwards in the first few meters below the ground surface, following infrequent episodic precipitation. This means that waste packages in the upper few meters experience different release and transport mechanisms than deeper waste packages. The paper describes the Vaalputs repository, and approaches taken for the safety assessment. The paper also presents results of the safety assessment, and describes the implications of those results on waste management activities at Vaalputs. References IAEA, Safety Assessment Methodologies for Near Surface Disposal Facilities, Results of a Coordinated Research Project, Volume 1: Review and Enhancement of Safety Assessment Approaches and Tools, IAEA- ISAM, International Atomic Energy Agency, 2004.

  20. ________________________ _____Environment, Health, & Safety _____ ______________________ Training Program

    E-print Network

    Eisen, Michael

    Safety Course Prerequisite: No Course Length: Four hour lecture plus one hour practical Medical Approval________________________ _____Environment, Health, & Safety _____ ______________________ Training that affect safety Explain safety and property considerations associated with high value/high consequence

  1. COLUMBIA UNIVERSITY Radiation Safety Program

    E-print Network

    Jia, Songtao

    COLUMBIA UNIVERSITY Radiation Safety Program Medical Center - T: 212-305-0303 F: 212 Health & Safety www.ehs.columbia.edu Revised May 2011 Please Submit in Duplicate to: The Radiation Safety: ______________________________________________ Date: ______________ Radiation Safety Officer at Receiving Institution

  2. Center for Intermodal Transportation Safety

    E-print Network

    Fernandez, Eduardo

    Center for Intermodal Transportation Safety and Security Panagiotis Scarlatos, Ph.D., Director Transportation Safety and Security #12;Center for Intermodal Transportation Safety and Security Partners #12 evacuations · Tracking systems for hazardous materials Center for Intermodal Transportation Safety

  3. Radiation Safety (Revised March 2010)

    E-print Network

    Kay, Mark A.

    Radiation Safety Manual (Revised March 2010) Updated December 2012 Stanford University, Stanford California #12; #12; Radiation Safety Manual (Revised March 2010) Updated Environmental Health and Safety, Stanford University, Stanford California #12; CREDITS This Radiation Safety

  4. Making the Postclosure Safety Case for the Proposed Yucca Mountain Repository

    SciTech Connect

    P. Swift; A.V. Luik

    2006-08-28

    The International Atomic Energy Agency (IAEA), in its advisory standard for geological repositories promulgated jointly with the Nuclear Energy Agency (NEA) of the Organization for Economic Co-operation and Development, explicitly distinguishes between the concepts of a safety case and a safety assessment. As defined in the advisory standard, the safety case is a broader set of arguments that provide confidence and substantiate the formal analyses of system safety made through the process of safety assessment. Although the IAEAYs definitions include both preclosure (i.e., operational) safety and post-closure performance in the overall safety assessment and safety case, the emphasis in here is on long-term performance after waste has been emplaced and the repository has been closed. This distinction between pre- and postclosure aspects of the repository is consistent with the U.S. regulatory framework defined by the U.S. Environmental Protection Agency (Chapter 40 of the Code of Federal Regulations, Part 197, or 40 CFR 197) [2] and implemented by the U.S. Nuclear Regulatory Commission (Chapter 10 of the Code of Federal Regulations, Part 63, or 10 CFR 63) [3]. The separation of the pre- and postclosure safety cases is also consistent with the way in which the U.S. Department of Energy has assigned responsibilities for developing the safety case. Bechtel SAIC Company is the Management and Operating contractor responsible for the design and operation of the Yucca Mountain facility and is therefore responsible for the preparation of the preclosure aspects of the safety case. Sandia National Laboratories has lead responsibility for scientific work evaluating post-closure performance, and therefore is responsible for developing the post-closure aspects of the safety case. In the context of the IAEA definitions, both preclosure and postclosure safety, including safety assessment and the safety case, will be documented in the license application being prepared for the proposed Yucca Mountain repository, and in the documents that support that license application.

  5. Science Education Safety

    NSDL National Science Digital Library

    Downloadable guides published by the Council of State Science Supervisors (CSSS) that provide information on laboratory safety practices in elementary and secondary schools. Topics include legal issues, the purchase, storage, and disposal of chemicals, chemical hygiene, and response to spills or accidents. There is also information on the use of plants or animals in the lab, protective equipment, laboratory layouts, glassware and electricity precautions, field-trip safety, and other topics. The site also includes a science safety checklist, recommendations for general lab safety, and links to safety information from other websites.

  6. Safety and IVHM

    NASA Technical Reports Server (NTRS)

    Goebel, Kai

    2012-01-01

    When we address safety in a book on the business case for IVHM, the question arises whether safety isn t inherently in conflict with the need of operators to run their systems as efficiently (and as cost effectively) as possible. The answer may be that the system needs to be just as safe as needed, but not significantly more. That begs the next question: How safe is safe enough? Several regulatory bodies provide guidelines for operational safety, but irrespective of that, operators do not want their systems to be known as lacking safety. We illuminate the role of safety within the context of IVHM.

  7. NASA Software Safety Standard

    NASA Technical Reports Server (NTRS)

    Rosenberg, Linda

    1997-01-01

    If software is a critical element in a safety critical system, it is imperative to implement a systematic approach to software safety as an integral part of the overall system safety programs. The NASA-STD-8719.13A, "NASA Software Safety Standard", describes the activities necessary to ensure that safety is designed into software that is acquired or developed by NASA, and that safety is maintained throughout the software life cycle. A PDF version, is available on the WWW from Lewis. A Guidebook that will assist in the implementation of the requirements in the Safety Standard is under development at the Lewis Research Center (LeRC). After completion, it will also be available on the WWW from Lewis.

  8. Missouri Elementary Science Safety Manual.

    ERIC Educational Resources Information Center

    Lemons, Judith L.

    The purpose of this safety manual is to provide a resource to help manage and minimize potential risks in science classrooms where students spend up to 60% of instructional time engaged in hands-on activities. Information on general laboratory safety, science equipment safety, safety with plants, safety with animals, safety with chemicals, field…

  9. NASA Safety Manual. Volume 3: System Safety

    NASA Technical Reports Server (NTRS)

    1970-01-01

    This Volume 3 of the NASA Safety Manual sets forth the basic elements and techniques for managing a system safety program and the technical methods recommended for use in developing a risk evaluation program that is oriented to the identification of hazards in aerospace hardware systems and the development of residual risk management information for the program manager that is based on the hazards identified. The methods and techniques described in this volume are in consonance with the requirements set forth in NHB 1700.1 (VI), Chapter 3. This volume and future volumes of the NASA Safety Manual shall not be rewritten, reprinted, or reproduced in any manner. Installation implementing procedures, if necessary, shall be inserted as page supplements in accordance with the provisions of Appendix A. No portion of this volume or future volumes of the NASA Safety Manual shall be invoked in contracts.

  10. Environmental Health & Safety Safety in the Workplace

    E-print Network

    Jawitz, James W.

    and lengths from Medline BD Disposable Luer-LokTM Syringes - provides secure connection to prevent needle from - available in sizes XXS ­ XL from HexAmor Turtleskin Insider Plus Safety Glove Liners - available in sizes

  11. POSITION POSTING Liaison Librarian

    E-print Network

    Kambhampati, Patanjali

    POSITION POSTING Liaison Librarian Assistant or Associate Librarian (non-tenure track) DurationGill Library seeks an innovative, autonomous and resourceful librarian to assist in the provision of a range.mcgill.ca and www.mcgill.ca/library). The Regulations Relating to the Employment of Librarian Staff can be found

  12. Tackling Post's Correspondence Problem

    Microsoft Academic Search

    Ling Zhao

    2002-01-01

    Post's correspondence problem (PCP) is a classic undecid- able problem. Its theoretical unbounded search space makes it hard to judge whether a PCP instance has a solution, and to find the solutions if they exist. In this paper, we describe new application-dependent meth- ods used to eciently find optimal solutions to individual instances, and to identify instances with no solution.

  13. Post-stroke depression

    Microsoft Academic Search

    G. L. Lenzi; M. Altieri; I. Maestrini

    2008-01-01

    Post-stroke depression (PSD) is the most frequent psychiatric complication of stroke. Its prevalence has been estimated to be around 30–35%, ranging from 20 to 60%. Despite the extensive literature on this topic, there is no agreement on causal mechanisms, risk factors and consequences of PSD. Stroke patients with PSD suffer higher mortality rates and show a minor improvement in rehabilitation

  14. Post trauma abdominal cocoon

    PubMed Central

    Kaur, Supreet; Doley, Rudra Prasad; Chabbhra, Mohinish; Kapoor, Rajeev; Wig, Jaidev

    2014-01-01

    Abdominal cocoon or sclerosing peritonitis refers to a rare cause of intestinal obstruction due to formation of a membrane encasing the bowel. We report a case of abdominal cocoon post blunt trauma abdomen. The patient presented with a history of subacute intestinal obstruction and a mobile abdomen lump. Abdominal cocoon was diagnosed on computed tomography. He underwent adhesiolysis with excision of membrane. PMID:25590647

  15. POST NATAL ACUPUNCTURE

    Microsoft Academic Search

    Debra Betts

    Traditional Chinese medicine has very firm ideas on the amount of care and rest appropriate to the first month or longer after childbirth that contrast with the modern emphasis on returning to normal activities within a week or two. Recovery after childbirth can be promoted by appropriate tonifying acupuncture treatments and dietary advice. Furthermore specific problems post-birth, for example persistent

  16. Quality and safety aspects in histopathology laboratory

    PubMed Central

    Adyanthaya, Soniya; Jose, Maji

    2013-01-01

    Histopathology is an art of analyzing and interpreting the shapes, sizes and architectural patterns of cells and tissues within a given specific clinical background and a science by which the image is placed in the context of knowledge of pathobiology, to arrive at an accurate diagnosis. To function effectively and safely, all the procedures and activities of histopathology laboratory should be evaluated and monitored accurately. In histopathology laboratory, the concept of quality control is applicable to pre-analytical, analytical and post-analytical activities. Ensuring safety of working personnel as well as environment is also highly important. Safety issues that may come up in a histopathology lab are primarily those related to potentially hazardous chemicals, biohazardous materials, accidents linked to the equipment and instrumentation employed and general risks from electrical and fire hazards. This article discusses quality management system which can ensure quality performance in histopathology laboratory. The hazards in pathology laboratories and practical safety measures aimed at controlling the dangers are also discussed with the objective of promoting safety consciousness and the practice of laboratory safety. PMID:24574660

  17. Federal Labor Relations Authority

    NSDL National Science Digital Library

    Established by the Civil Service Reform Act of 1978, the Federal Labor Relations Authority (FLRA) is an independent agency that is responsible for administering the labor-management relations program for close to 2 million federal employees across the world. As noted on the Web site, their mission is "to promote stable and constructive labor-management relations that contribute to an efficient and effective government." To achieve that end, the FLRA's site provides a host of information about recent cases decided by the Authority, along with information about its activities and current staff roster. Visitors to the site will want to take a look at the FLRA strategic plan for the period from 2002-2005, and review previous annual reports filed by the Authority, which are located in the News and Publications area of the site.

  18. Return applications no later than Friday, September 23, 2011 to: 200 Transportation and Safety Building

    E-print Network

    Minnesota, University of

    and Safety Building 511 Washington Ave S.E. Minneapolis, MN 55455 haag0025@.umn.edu fax: 612-625-6381 Immediate Posting and Distribution ITS Institute Student Travel Awards The Intelligent Transportation 23, 2011 to: Shawn Haag Program Coordinator 200 Transportation and Safety Building 511 Washington

  19. Fuel Safety Activities in Korea

    SciTech Connect

    Auh, Geun-Sun; Shin, A.D.; Lee, J.S.; Woo, S.W.; Ryu, Y.H. [Korea Institute of Nuclear Safety (KINS), 19 Gusong-dong, Yusong-gu, Daejon, Korea 305-338 (Korea, Republic of); Kim, Jun-Hwan; Kim, S.K.; Jeong, Y.H. [Korea Atomic Energy Research Institute (KAERI), 150 Dukjin-dong, Yusong-gu, Daejon, Korea 305-353 (Korea, Republic of)

    2007-07-01

    The current regulatory requirements for fuel performance were based on earlier test data of fresh or low burnup Zircaloy fuels of less than 40 GWD/MTU. Most countries have not changed the current regulatory requirements even if they are actively investigating the high burnup and new cladding alloy effects. Korea agrees with commonly accepted international consensus that although there are technical issues requiring resolutions, these issues do not constitute immediate safety concerns. The high burnup fuel reactor performance experiences of Korea do not show any major problems even if there have been some burnup related fuel failures which are described in the paper. KINS has recommended the industry to have lower fuel failure rates than 1-2 per 50,000 fuel rods. A research project of High Burnup Fuel Safety Tests and Evaluations has started in 2002 under a joint cooperation of KAERI/KNFC/KEPRI and KINS to obtain performance results of high burnup fuel and to develop evaluation technologies of high burnup fuel safety issues. From 1998, KINS has closely monitored and actively participated in international activities such as OECD/NEA CABRI Water Loop Program to reflect on regulatory requirements if needed. KINS will closely monitor the high burnup fuel performances of Korea to strength the regulatory activities if needed. The research activities in Korea including of LOCA and RIA being performed at KAERI with active supports of the industry are summarized in the paper. (authors)

  20. 75 FR 47715 - Safety Zone; Kanawha River Mile 56.7 to 57.6, Charleston, WV

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-09

    ...the river. This safety zone is needed to protect persons and vessels from the potential safety hazards associated with the Toyota Governor's Cup Jet Ski Race. Entry into this zone is prohibited unless specifically authorized by the Captain of the...

  1. MEETING REPORTS: Second Review Meeting of the Contracting Parties to the Convention on Nuclear Safety

    Microsoft Academic Search

    Barbara Rafferty

    2002-01-01

    Vienna, 15-26 April 2002 The Second Review Meeting of the Contracting Parties to the Convention on Nuclear Safety was held in the Headquarters of the International Atomic Energy Agency in Vienna from 15-26 April 2002, under the chairmanship of the President, Mr Miroslav Gregoric, Director of the Slovenian Nuclear Safety Authority. The Convention on Nuclear Safety entered into force in

  2. An Application of System Dynamics and Risk Management Techniques to School Bus Safety Policy

    Microsoft Academic Search

    Bronwyn Howell; Mark Obren

    New Zealand's Land Transport Safety Authority (LTSA) has a dilemma in that it is charged with setting safety standards in a politically sensitive environment. However, the standard benefit\\/cost justification process for safety initiatives cannot adequately cater for catastrophic risk events of low probability, uncertain probabilistic distribution and high political impact. The school bus sector is one area where this dilemma

  3. 77 FR 43167 - Safety Zone; Electric Zoo Fireworks, East River, Randall's Island, NY

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-24

    ...enforcement of the temporary safety zone. Entering into, transiting...within the temporary safety zone is prohibited unless authorized...especially burning debris falling on passing or spectator vessels has the...fatalities. This temporary safety zone will restrict vessels from...

  4. 78 FR 24677 - Safety Zone; XA The Experimental Agency Fireworks, Pier 34, East River, NY

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-26

    ...enforcement of the temporary safety zone. Entering into, transiting...within the temporary safety zone is prohibited unless authorized...especially burning debris falling on passing or spectator vessels has the...fatalities. This temporary safety zone will restrict vessels from...

  5. Highway Safety Program Manual: Volume 16: Debris Hazard Control and Cleanup.

    ERIC Educational Resources Information Center

    National Highway Traffic Safety Administration (DOT), Washington, DC.

    Volume 16 of the 19-volume Highway Safety Program Manual (which provides guidance to State and local governments on preferred highway safety practices) concentrates on debris hazard control and cleanup. The purpose and objectives of such a program are outlined. Federal authority in the area of highway safety and policies regarding a debris control…

  6. Aggregate nonparametric safety analysis of traffic zones.

    PubMed

    Siddiqui, Chowdhury; Abdel-Aty, Mohamed; Huang, Helai

    2012-03-01

    Exploring the significant variables related to specific types of crashes is vitally important in the planning stage of a transportation network. This paper aims to identify and examine important variables associated with total crashes and severe crashes per traffic analysis zone (TAZ) in four counties of the state of Florida by applying nonparametric statistical techniques such as data mining and random forest. The intention of investigating these factors in such aggregate level analysis is to incorporate proactive safety measures in transportation planning. Total and severe crashes per TAZ were modeled to provide predictive decision trees. The variables which carried higher weight of importance for total crashes per TAZ were - total number of intersections per TAZ, airport trip productions, light truck productions, and total roadway segment length with 35 mph posted speed limit. The other significant variables identified for total crashes were total roadway length with 15 mph posted speed limit, total roadway length with 65 mph posted speed limit, and non-home based work productions. For severe crashes, total number of intersections per TAZ, light truck productions, total roadway length with 35 mph posted speed limit, and total roadway length with 65 mph posted speed limit were among the significant variables. These variables were further verified and supported by the random forest results. PMID:22269515

  7. Post-Operation Storage Options for Space Fission Reactors

    NASA Astrophysics Data System (ADS)

    El-Genk, M. S.

    Interplanetary exploration, select civilian missions in Earth orbits with altitudes >1000 km and human outposts on the moon and Mars could be enabled by fission reactor power and propulsion systems, when the solar option is impractical or inadequate. This paper presents estimates of pre- and post-operation radiological source terms of space reactors and discusses some of the requirements that affect their design, choices of components and the power system safety and reliability. Also discussed are post-operation storage options of fission reactor that might be used in future space exploration missions and for surface power.

  8. Coping strategies: a psychoeducational approach to post-traumatic symptomatology.

    PubMed

    Benham, E

    1995-06-01

    Survivors of extensive childhood abuse frequently present complicated clinical dilemmas in the inpatient setting; they experience complex post-traumatic and dissociative symptomatology, such as flashbacks and other reexperiencing phenomena, as well as intense affects and self-destructive impulses. Such patients seek recommendations of how to manage their post-traumatic symptomatology, as well as how to tolerate intense affects and maintain safety. The nursing staff at McLean Hospital's Dissociative Disorders Program have developed a psychoeducational approach that patients have found useful. Coping strategies, which the patients learn to formulate, help clients stall impulsivity and dissociative episodes through the use of healthy diversions, grounding techniques, and support networks. PMID:7666386

  9. Resolving conflicting safety cultures

    SciTech Connect

    Slider, J.E. (Slider Associates, Inc., Washington, DC (United States)); Patterson, M. (SCIENTECH, Rockville, MD (United States))

    1993-01-01

    Several nuclear power plant sites have been wounded in the crossfire between two distinct corporate cultures. The traditional utility culture lies on one side and that of the nuclear navy on the other. The two corporate cultures lead to different perceptions of [open quotes]safety culture.[close quotes] This clash of safety cultures obscures a very important point about nuclear plant operations: Safety depends on organizational learning. Organizational learning provides the foundation for a perception of safety culture that transcends the conflict between utility and nuclear navy cultures. Corporate culture may be defined as the knowledge, attitudes, and beliefs shared by employees of a given company. Safety culture is the part of corporate culture concerning shared attitudes and beliefs affecting individual or public safety. If the safety culture promotes behaviors that lead to greater safety, employees will tend to [open quotes]do the right thing[close quotes] even when circumstances and formal guidance alone do not ensure that actions will be correct. Safety culture has become particularly important to nuclear plant owners and regulators as they have sought to establish and maintain a high level of safety in today's plants.

  10. [Patient safety in Sweden].

    PubMed

    Rutberg, H; Eckhardt, M; Biermann, O

    2015-01-01

    This article describes the patient safety work in Sweden and the cooperation between the Nordic countries in the area of patient safety. It depicts the national infrastructure, methods and partners in patient safety work as well as the development in key areas. Since 2000, the interest in patient safety and quality issues has significantly increased. A national study (2009) showed that more than 100,000 patients (8.6?%) experienced preventable harm in hospitals. Since 2007, all Swedish counties and regions work on the "National commitment for increased patient safety" to systematically minimize adverse events in the healthcare system. Also, a national strategy for patient safety has been proposed based on a new law regulating the responsibility for patient safety (2011) and a zero vision in terms of preventable harm and adverse events. The Nordic collaboration in this field currently focuses on the development of indicators and quality measurement with respect to nosocomial infections, harm in inpatient somatic care, patient safety culture, hospital mortality and polypharmacy in the elderly. The Nordic collaboration is driven by the development, exchange and documentation of experiences and evidence on patient safety indicators. The work presented in this article is only a part of the Swedish and the Nordic efforts related to patient safety and provides an interesting insight into how this work can be carried out. PMID:25430735

  11. Principles of Safety Pharmacology

    PubMed Central

    Pugsley, M K; Authier, S; Curtis, M J

    2008-01-01

    Safety Pharmacology is a rapidly developing discipline that uses the basic principles of pharmacology in a regulatory-driven process to generate data to inform risk/benefit assessment. The aim of Safety Pharmacology is to characterize the pharmacodynamic/pharmacokinetic (PK/PD) relationship of a drug's adverse effects using continuously evolving methodology. Unlike toxicology, Safety Pharmacology includes within its remit a regulatory requirement to predict the risk of rare lethal events. This gives Safety Pharmacology its unique character. The key issues for Safety Pharmacology are detection of an adverse effect liability, projection of the data into safety margin calculation and finally clinical safety monitoring. This article sets out to explain the drivers for Safety Pharmacology so that the wider pharmacology community is better placed to understand the discipline. It concludes with a summary of principles that may help inform future resolution of unmet needs (especially establishing model validation for accurate risk assessment). Subsequent articles in this issue of the journal address specific aspects of Safety Pharmacology to explore the issues of model choice, the burden of proof and to highlight areas of intensive activity (such as testing for drug-induced rare event liability, and the challenge of testing the safety of so-called biologics (antibodies, gene therapy and so on.). PMID:18604233

  12. Extending Safety Culture Development through Communication - 12366

    SciTech Connect

    Sneve, M.K. [Norwegian Radiation Protection Authority, N-1332 Osteras (Norway); Kiselev, M. [Federal Medical-Biological Agency of Russia, Volokolamskoe shosse 30, 123182 Moscow (Russian Federation); Shandala, N.K. [Federal Medical-Biological Center,123128, Moscow (Russian Federation); Shempelev, V.; Shulgin, A. [Science and Engineering Center of the Nuclear Regulatory Service, 107140, Moscow (Russian Federation)

    2012-07-01

    The Norwegian Radiation Protection Authority has been implementing a regulatory support program in the Russian Federation for over 10 years, as part of the Norwegian government's Plan of Action for enhancing nuclear and radiation safety in northwest Russia. The overall long-term objective is the enhancement of safety culture. The project outputs have included appropriate regulatory threat assessments, to determine the hazardous activities which are most in need of enhanced regulatory supervision; and development of the norms, standards and regulatory procedures, necessary to address the often abnormal conditions at nuclear legacy sites. Project outputs have been prepared and subsequently confirmed as official regulatory documents of the Russian Federation. The continuing program of work focuses on practical application of the enhanced regulatory framework as applied to legacy sites, including safe management of radioactive wastes arising in the process of site remediation. One of the lessons learnt from this practical application is the importance of effective communication at all levels: - between managers and shop workers; - between different operators - e.g. waste producers and waste disposal organisations; - between operators and regulators; - between nuclear safety regulators, radiation protection regulators and other pollution and safety regulators; - between scientists, policy makers and wider stakeholders; and - between all of those mentioned above. A key message from this work is that it is not just an issue of risk communication; rather all aspects of communication can contribute to safety culture enhancement to support effective and efficient risk management, including the role of regulatory supervision. (authors)

  13. System safety based on a coordinated principle-based theme

    SciTech Connect

    Cooper, J.A.

    1998-08-01

    In this paper, the authors demonstrate a logical progression for the identification of assets, threats, vulnerabilities, and protective measures, based on a structured approach that incorporates the results of the previous paper. The authors utilize a logical structure for identifying the constituents of the problem, derive appropriate applicable principles, and demonstrate a technique for incorporating the principles into a coordinated safety theme. They also show how to qualitatively assess such generally non-quantifiable items such as safety-component and safety-system response to severe abnormal environments. An illustrative example is followed step-by-step through to a safety system design approach and a safety assessment approach. The general approach is illustrated here through an example, generally representing a test rocket launch scenario, where the concern is the potential for loss of life.

  14. 1. Post card view of the bridge, c. 1910. Post ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Post card view of the bridge, c. 1910. Post card courtesy Carol Poh Miller. Photocopy by Berni Rich, Score Photographers Cleveland, OH - B & O Railroad Bridge Number 464, Spanning Old Ship Canal & Cuyahoga River, Cleveland, Cuyahoga County, OH

  15. 10. FLOOR 1; CENTER POST AND POSTS UNDER STONE BEAMS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. FLOOR 1; CENTER POST AND POSTS UNDER STONE BEAMS WHICH SUPPORT BRIDGE BEAMS FOR BRIDGE TREES; WEDGES FOR ADJUSTING HEIGHT OF BRIDGE TREE CAN BE SEEN - Shelter Island Windmill, Manwaring Road, Shelter Island, Suffolk County, NY

  16. Authors on Film.

    ERIC Educational Resources Information Center

    Geduld, Harry M., Ed.

    Different authors' attitudes toward film are revealed through five different sections of this book: (1) articles, essays, and reviews pertaining to the silent cinema and the transition to sound; (2) general statements on the film medium or filmmakers and their messages; (3) essays dealing with the problems, involvements, and reflections of the…

  17. Case Authors Directory

    NSDL National Science Digital Library

    2010-01-01

    One of our goals is to build a community of case study teachers in science and engineering. Our directory lists all our case authors as well as case method practitioners (many of them trained by us) teaching in high school, community college, and university settings.

  18. Author Identity Bibliographic

    E-print Network

    Pitman, Jim

    (Web 2.0/3.0): del.icio.us CiteULike,Connotea,BibSonomy, Freebase, Zotero, Rexa, kReef, ... #12;Author Subscription Services MathSciNet, Zentralblatt MATH Web of Science (Thomson Reuters) Emerging Free Services Google Scholar, Scirus (Elsevier), WorldCat, OAIster, CiteSeer, PubMed, ... Social/Semantic Web Services

  19. Overtime Authorization Agreement Date __________________

    E-print Network

    Farritor, Shane

    , ________________________________, authorize ____________________________________ Supervisor Employee to work _______ hours of overtime on _________________________. Date Employee will be compensated for these hours through Overtime pay Compensatory time. Nonexempt employees must be paid for all hours worked in excess of 40 hours (50 hours for agricultural employees

  20. Children as Authors Handbook.

    ERIC Educational Resources Information Center

    Hawaii State Dept. of Education, Honolulu. Office of Instructional Services.

    Intended for teachers, librarians, and administrators, this handbook explores the possibilities of implementing a "Children as Authors" project by using collaborative and integrative teaching strategies to motivate elementary school children to write. After describing the project and explaining its benefits, the handbook explores ways teachers and…

  1. The Traust Authorization Service

    Microsoft Academic Search

    Adam J. Lee; Marianne Winslett; Jim Basney; Von Welch

    2008-01-01

    In recent years, trust negotiation has been proposed as a novel authorization solution for use in open-system environments, in which resources are shared across organizational boundaries. Researchers have shown that trust negotiation is indeed a viable solution for these environments by developing a number of policy languages and strategies for trust negotiation that have desirable theoretical properties. Further, existing protocols,

  2. Author Identification Systems

    ERIC Educational Resources Information Center

    Wagner, A. Ben

    2009-01-01

    Many efforts are currently underway to disambiguate author names and assign unique identification numbers so that publications by a given scholar can be reliably grouped together. This paper reviews a number of operational and in-development services. Some systems like ResearcherId.Com depend on self-registration and self-identification of a…

  3. Comparing American Authors

    NSDL National Science Digital Library

    Ms. Hall

    2010-03-24

    How are Edgar Allen Poe and Mark Twain similar? How similar are Edgar Allen Poe and Mark Twain really? They are two of the greatest authors from the 19th Century but they appear to be very different. Read section 7 here of Mark Twain s Style and then read this excerpt from Twain's Tom Sawyer to fully understand his writing style. What things ...

  4. Author's personal copy COMMUNICATION

    E-print Network

    Borgstahl, Gloria

    is weak and of poor quality indicating that these regions are disordered and/or assume multiple positionsAuthor's personal copy COMMUNICATION Structure of the Full-length Human RPA14/32 Complex Gives, have been determined for the full-length protein in multiple crystal forms. In all crystals

  5. Site authorization service (SAZ)

    SciTech Connect

    Dane Skow; Igor Mandrichenko; Vijay Sehkri

    2003-10-01

    In this paper the authors present a methodology to provide an additional level of centralized control for the grid resources. This centralized control is applied to site-wide distribution of various grids and thus provides an upper hand in the maintenance.

  6. Lightweight Materials and Safety

    NSDL National Science Digital Library

    The International Council on Clean Transportation

    In this report presented at a California Air Resources Board (CARB) workshop by the International Council on Clean Transportation (ICCT), the relationship between mass, size, safety, and materials are examined. After describing the factors influencing vehicle safety (drivers and environment, size and weight, crashworthiness, and materials), solutions to safer vehicles are presented. It is determined to improve safety, mass should be reduced through the use of lighter high-strength materials (aluminum and steel), while also improving vehicle geometry and design to absorb impact. An example of improved safety through high strength-materials and geometry is illustrated with design changes Honda has made to the Civic (05-06 models). Also compared in this report are material and safety studies by the Society of Automotive Engineers (SAE) and the National Highway Traffic Safety Administration (NHTSA).

  7. Recycling Authorizations: Toward Secondary and Approximate Authorizations Model

    E-print Network

    1 Recycling Authorizations: Toward Secondary and Approximate Authorizations Model (SAAM) Konstantin. This paper establishes the concept of recycling previously made authorizations for serving new authorization by conventional authorization systems. #12;2 This paper introduces the concept of recycling previously made

  8. INC424 for Patients With Myelofibrosis, Post Polycythemia Myelofibrosis or Post-essential Thrombocythemia Myelofibrosis

    ClinicalTrials.gov

    2015-04-07

    Myelofibrosis (PMF); Post Polycythemia Myelofibrosis (PPV MF); Post-essential Thrombocythemia Myelofibrosis (PET-MF); Myelofibrosis; Post Polycythemia Myelofibrosis; Post-essential Thrombocythemia Myelofibrosis

  9. Thermal reactor safety

    SciTech Connect

    Not Available

    1980-06-01

    Information is presented concerning new trends in licensing; seismic considerations and system structural behavior; TMI-2 risk assessment and thermal hydraulics; statistical assessment of potential accidents and verification of computational methods; issues with respect to improved safety; human factors in nuclear power plant operation; diagnostics and activities in support of recovery; LOCA transient analysis; unresolved safety issues and other safety considerations; and fission product transport.

  10. Hydrogen Technologies Safety Guide

    SciTech Connect

    Rivkin, C.; Burgess, R.; Buttner, W.

    2015-01-01

    The purpose of this guide is to provide basic background information on hydrogen technologies. It is intended to provide project developers, code officials, and other interested parties the background information to be able to put hydrogen safety in context. For example, code officials reviewing permit applications for hydrogen projects will get an understanding of the industrial history of hydrogen, basic safety concerns, and safety requirements.

  11. [Safety nonsteroidal antiinflammatory drugs].

    PubMed

    Oscanoa-Espinoza, Teodoro Julio

    2015-01-01

    The choice of a specific medication belonging to a drug class is under the criteria of efficacy, safety, cost and suitability. NSAIDs currently constitute one of the most consumed drug in the world, so it is very important review of the safety aspects of this drug class. This review has the objective of analyze the safety of NSAIDs on 3 main criteria: gastrolesivity, cardiotoxicity and nephrotoxicity. PMID:25760746

  12. [Safety of influenza vaccination in asthmatics].

    PubMed

    Kmiecik, Tomasz; Sek, Karolina; Górski, Pawe?

    2006-01-01

    The common cause of exacerbations in asthmatics are viral infections. Influenza infection especially increases the risk of respiratory exacerbations. The ACIP report puts asthma among indications to regular influenza vaccinations. In practice, many physicians doubt in effectiveness and safety of vaccination in patients suffering from allergy. It caused such procedures were not included in asthma guidelines published by other authors. Our study confirmed the safety of influenza split vaccine vaccination in asthmatics. We proved that vaccination had not any influence on asthma control in 14-day period after injection. We showed also high frequency of, mostly local, side effects. These events were generally mild and transient. PMID:17427144

  13. Washington Post Online

    NSDL National Science Digital Library

    The Washington Post has an online version on the Web. The site includes the full text of the daily edition, plus news from the 50 states, a daily congressional calendar, and over 1000 pages of links to news, reference and Web sites for over 200 countries around the world. Features include movie reviews, book reviews (along with selected first chapters of books), links to over fifteen online comic strips, and sports features. A searchable archive of the previous two weeks papers is available and, in the near future, an archive from 1986 to the present will be available. There are also several chat rooms on various subjects ranging from business to local Washington, DC issues. While the Post is well known for its international and national coverage, the online version is also very strong with respect to local area news.

  14. Post-stroke depression

    Microsoft Academic Search

    J. W. G. Tiller

    1992-01-01

    Depression is present in 25–30% of stroke patients: though associated with physical disability and loss of function, it cannot be explained simply as a response to the disability. The severity of depression correlates with proximity of the lesion to the left anterior frontal pole, while right hemisphere lesions show the reverse trend. Post-stroke depressions may last more than 7–8 months

  15. Monitoring food safety violation reports from internet forums.

    PubMed

    Kate, Kiran; Negi, Sumit; Kalagnanam, Jayant

    2014-01-01

    Food-borne illness is a growing public health concern in the world. Government bodies, which regulate and monitor the state of food safety, solicit citizen feedback about food hygiene practices followed by food establishments. They use traditional channels like call center, e-mail for such feedback collection. With the growing popularity of Web 2.0 and social media, citizens often post such feedback on internet forums, message boards etc. The system proposed in this paper applies text mining techniques to identify and mine such food safety complaints posted by citizens on web data sources thereby enabling the government agencies to gather more information about the state of food safety. In this paper, we discuss the architecture of our system and the text mining methods used. We also present results which demonstrate the effectiveness of this system in a real-world deployment. PMID:25160357

  16. Sequential Generalized Likelihood Ratio Tests for Vaccine Safety Evaluation

    PubMed Central

    Shih, Mei-Chiung; Lai, Tze Leung; Heyse, Joseph F.; Chen, Jie

    2010-01-01

    SUMMARY The evaluation of vaccine safety involves pre-clinical animal studies, pre-licensure randomized clinical trials and post-licensure safety studies. Sequential design and analysis are of particular interest because they allow early termination of the trial or quick detection that the vaccine exceeds a prescribed bound on the adverse event rate. After a review of recent developments in this area, we propose a new class of sequential generalized likelihood ratio tests for evaluating adverse event rates in two-armed pre-licensure clinical trials and single-armed post-licensure studies. The proposed approach is illustrated using data from the Rotavirus Efficacy and Safety Trial (REST). Simulation studies of the performance of the proposed approach and other methods are also given. PMID:20799244

  17. Transport Safety Research Centre

    NSDL National Science Digital Library

    The Transportation Safety Research Centre conducts research on the causes of accidents and injuries in real world crashes. The Centre aims to "reduce traffic casualties and mitigate the broader impact of transport on society by conducting world-leading basic and applied research." The Key Interests section allows visitors to read more about the aspects of transportation safety investigated by the center, including road user behavior, infrastructure safety research, and road safety policy. Two publications are also available for download: "Feasibility study for equipment database and exposure data evaluation" and "Effectiveness of Electronic Stability Control Systems in Great Britain."

  18. SHIPBOARD LABORATORY SAFETY PROGRAM

    E-print Network

    SHIPBOARD LABORATORY SAFETY PROGRAM INTEGRATED OCEAN DRILLING PROGRAM U.S. IMPLEMENTING ................................................................................................................................7 Other TAMU and SIEM Offshore Policies and Programs

  19. Lift truck safety review

    SciTech Connect

    Cadwallader, L.C.

    1997-03-01

    This report presents safety information about powered industrial trucks. The basic lift truck, the counterbalanced sit down rider truck, is the primary focus of the report. Lift truck engineering is briefly described, then a hazard analysis is performed on the lift truck. Case histories and accident statistics are also given. Rules and regulations about lift trucks, such as the US Occupational Safety an Health Administration laws and the Underwriter`s Laboratories standards, are discussed. Safety issues with lift trucks are reviewed, and lift truck safety and reliability are discussed. Some quantitative reliability values are given.

  20. Safety Logics I: Absolute Safety Zhisheng Huang and John Bell #

    E-print Network

    Huang, Zhisheng

    medical safety­critical system would consider states in which the patient dies as a result of treatmentSafety Logics I: Absolute Safety Zhisheng Huang and John Bell # Applied Logic Group Department}@dcs.qmw.ac.uk Abstract In this paper we distinguish between absolute safety and normative safety, and develop a formal