PBT-1 (clioquinol), is undergoing phase II clinical trials by Prana Biotechnology Ltd for the potential treatment of Alzheimer's disease. By October 2004, the company had planned phase III trials for the first half of 2005. PMID:15675609
This thesis is about the process behind building, tuning, and composing music for a new set of metallophones called the "Lightbulb" instruments. This project began in 2011 and has continued to expand over the past two years: the first piece to be written for the instruments is titled Prana, and this thesis describes how the process of building and tuning the instruments informed the compositional process behind Prana. The premiere of Prana led to the formation of the Lightbulb Ensemble, which performs on these new instruments. The instruments and the group continue to develop.
Adlard, Paul Anthony; Bush, Ashley Ian
As evidence for the role of metal ion dysregulation in the pathogenesis of multiple CNS disorders grows, it has become important to more precisely identify and differentiate the biological effects of various pharmacological modulators of metal ion homeostasis. This is particularly evident in disorders such as Alzheimer’s disease (AD), where the use of metal chaperones (that transport metals), as opposed to chelators (which exclude metals from biological interactions), may prove to be the first truly disease modifying approach for this condition. The purpose of this mini-review is to highlight the emerging notion that metal chaperones, such as PBT2 (Prana Biotechnology), modulate a variety of critical pathways affecting key aspects of the AD cascade to provide a more “holistic” approach to the treatment of this disease. PMID:22403554
Rao, A. Venkoba
Ayurveda now among the alternative complementary systems of medicine is over 5000 years old. Its origin and the compilation of Caraka Samhita are noted. The nature of mind as a sensory and a motor organ, its structure and functions are discussed. The concept of Thdosha theory and Trigunas are explained besides the so-called master-forms of Doshas namely Prana, Tejas and Ojas. The constituional and tempermental types depending upon the doshas are described. These determine diagnoses and guide treatment. Ayurveda is highlighted as a holistic system with its concern for prevention of disease and promotion of health. Disease denotes failure of prophylaxis. Some methods of Ayurvedic therapy are mentioned. PMID:21206574
Ron, Santiago R.; Venegas, Pablo J.; Toral, Eduardo; Morley Read; Diego A. Ortiz; Manzano, Andrea L.
Abstract We present a new phylogeny, based on DNA sequences of mitochondrial and nuclear genes, for frogs of the genus Osteocephalus with emphasis in the Osteocephalus buckleyi species complex. Genetic, morphologic, and advertisement call data are combined to define species boundaries and describe new species. The phylogeny shows strong support for: (1) a basal position of Osteocephalus taurinus + Osteocephalus oophagus, (2) a clade containing phytotelmata breeding species, and (3) a clade that corresponds to the Osteocephalus buckleyi species complex. Our results document a large proportion of hidden diversity within a set of populations that were previously treated as a single, widely distributed species, Osteocephalus buckleyi. Individuals assignable to Osteocephalus buckleyi formed a paraphyletic group relative to Osteocephalus verruciger and Osteocephalus cabrerai and contained four species, one of which is Osteocephalus buckleyi sensu stricto and three are new. Two of the new species are shared between Ecuador and Peru (Osteocephalus vilmae sp. n. and Osteocephalus cannatellai sp. n.) and one is distributed in the Amazon region of southern Peru (Osteocephalus germani sp. n.) We discuss the difficulties of using morphological characters to define species boundaries and propose a hypothesis to explain them. PMID:23166473
Medicine, social conditions, culture and politics are inextricably bound as determinants of health and wellbeing. In Cuba, perhaps this is nowhere more evident than in the arduous struggle to consider non-discriminatory analysis of gender-sensitive components as fundamental to population health, medical practice and research; national policy; and above all, public consciousness. Among the standard-bearers of this cause is Mariela Castro, psychologist and educator with a master's degree in sexuality, who directs the National Sex Education Center (CENESEX), its journal Sexologia y Sociedad, and the National Commission for Comprehensive Attention to Transsexual People. The Center's work is at the vortex of national polemics on sexuality, approaches to sex education and health, and respect for the human rights of people of differing sexual orientations and gender identities. The daughter of President Raúl Castro and the late Vilma Espín--who, as founder and leader of the Federation of Cuban Women, pioneered the defense of both women and homosexuals--Mariela Castro nevertheless speaks with her own voice in national as well as international debates. MEDICC Review talked with her about the range of issues that link gender to WHO's broad definition of health as the highest level of physical and mental wellbeing. PMID:22580546
Boomsma, Aaron; Bhattacharya, Sayantan; Troolin, Dan; Pothos, Stamatios; Vlachos, Pavlos
Uncertainty quantification in planar particle image velocimetry (PIV) measurement is critical for proper assessment of the quality and significance of reported results. New uncertainty estimation methods have been recently introduced generating interest about their applicability and utility. The present study compares and contrasts current methods, across two separate experiments and three software packages in order to provide a diversified assessment of the methods. We evaluated the performance of four uncertainty estimation methods, primary peak ratio (PPR), mutual information (MI), image matching (IM) and correlation statistics (CS). The PPR method was implemented and tested in two processing codes, using in-house open source PIV processing software (PRANA, Purdue University) and Insight4G (TSI, Inc.). The MI method was evaluated in PRANA, as was the IM method. The CS method was evaluated using DaVis (LaVision, GmbH). Utilizing two PIV systems for high and low-resolution measurements and a laser doppler velocimetry (LDV) system, data were acquired in a total of three cases: a jet flow and a cylinder in cross flow at two Reynolds numbers. LDV measurements were used to establish a point validation against which the high-resolution PIV measurements were validated. Subsequently, the high-resolution PIV measurements were used as a reference against which the low-resolution PIV data were assessed for error and uncertainty. We compared error and uncertainty distributions, spatially varying RMS error and RMS uncertainty, and standard uncertainty coverages. We observed that qualitatively, each method responded to spatially varying error (i.e. higher error regions resulted in higher uncertainty predictions in that region). However, the PPR and MI methods demonstrated reduced uncertainty dynamic range response. In contrast, the IM and CS methods showed better response, but under-predicted the uncertainty ranges. The standard coverages (68% confidence interval) ranged from
Rosch, Paul J
The concept of a "life energy" can be found in many cultures in the present time, as well as in past eras reaching back to the ancients. Variously called qi (chi), ki, the "four humors,"prana, "archaeus,"cosmic aether,"universal fluid,"animal magnetism," and "odic force," among other names, this purported biofield is beginning to yield its properties and interactions to the scientific method. Subtle energy is the term used in this chapter, which traces the recent history of subtle energy studies from Harold Saxton Burr and Björn Nordenström to Jim Oschman and Jacques Benveniste. This work takes signaling in living systems from the chemical/molecular to the physical/atomic level of communication. Effects on heart rate variability, stress response, inflammation, and the vagus nerve have been demonstrated and raise the question--Can the power of subtle energies be harnessed for health enhancement? It is fully accepted that good health depends on good communication both within the organism and between the organism and its environment. Sophisticated imaging procedures brought to bear on telomere, stem cell, and genetic research are confirming the ability of meditation and some other traditional practices to promote optimal health through stress reduction. PMID:19735252
Singh, Shakuntala A.; Singh, Ajai R.
In the light of Sri Aurobindo's philosophy, this paper looks into some of the problems of contemporary man as an individual, a member of society, a citizen of his country, a component of this world, and of nature itself. Concepts like Science; Nature,;Matter; Mental Being; Mana-purusa; Prana-purusa; Citta-purusa; Nation-ego and Nation-soul; True and False Subjectivism; World-state and World-union; Religion of Humanism are the focus of this paper. Nature: Beneath the diversity and uniqueness of the different elements in Nature there is an essential unity that not only allows for this diversity but even supports it. Nature is both a benefactor and a force: a benefactor, because it acts to carry out the evolution of mankind; a force, because it also supplies the necessary energy and momentum to achieve it. Natural calamities: If mankind can quieten the tsunamis and cyclones and droughts and earthquakes that rage within, and behave with care and compassion towards Nature, not exploiting, denuding, or denigrating it, there is a strong possibility that Nature too will behave with equal care and compassion towards man and spare him the natural calamities than rend him asunder. Science: The limitation of science become obvious, according to Sri Aurobindo, when we realize that it has mastered knowledge of processes and helped in the creation of machinery but is ignorant of the foundations of being and, therefore, cannot perfect our nature or our life. Science and philosophy: The insights of philosophy could become heuristic and algorithmic models for scientific experimentation. Matter: An interesting aspect of Sri Aurobindo's philosophy is his acceptance of the reality of matter even while highlighting its inadequacies; the ultimate goal, according to him, is the divination of matter itself. Purusa: If the mana-purusa (mental being) were to log on to the genuine citta-purusa (psychic formation), without necessarily logging off from the prana-purusa (frontal formation), it
von Brück, Michael
Carl Friedrich von Weizsäcker's thought is centred around the idea of the unity of reality. He tries to express this idea in his interpretation of quantum physics as well as on the background of neoplatonic thinking. Even his interest in Indian philosophies is based on this concept that would overcome the dualism of mind and matter as well as the dualism of subject and object. On this basis he also tries to reflect on his own inexpressible "mystical" experience in Tiruvannamalai, India, interpreting it with the help of the experience he has been told about by the Indian thinker Gopi Krishna. This is the concept of prana (vital energy) that he uses to find a common terminological ground for physical and mental events. According to Indian Advaita Vedanta, the non-dualistic interpretation of the Vedantic scriptures, reality is based on a non-dual oneness that is self-reflective, transparent and neither immanent nor transcendent but beyond any category. It is pure bliss in its self-expression. Human "mental" experience is a reflective mode of this one reality, subject and object coincide. The result is a holistic psycho-somatology. In view of these ideas Weizsäcker reformulates the notion of "matter". It is less an interaction of particles with specific mass than a non-dual net of interrelations and information, and this would correlate with a concept of mind (consciousness) that could be conceptualized as the energy of self-reflectivity in that very process. PMID:24974622