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1

Praziquantel, Mefloquine-Praziquantel, and Mefloquine-Artesunate-Praziquantel against Schistosoma haematobium: A Randomized, Exploratory, Open-Label Trial  

PubMed Central

Background Treatment and morbidity control of schistosomiasis relies on a single drug, praziquantel. Hence, there is a pressing need to develop additional therapeutics against schistosomiasis. The antimalarial drug mefloquine shows antischistosomal activity in animal models and clinical trials, which calls for further investigations. Methodology We comparatively assessed the efficacy and tolerability of the following treatments against Schistosoma haematobium in school-aged children in Côte d'Ivoire: (i) praziquantel (40 mg/kg; standard treatment); (ii) mefloquine (25 mg/kg) combined with praziquantel (40 mg/kg); and (iii) mefloquine-artesunate (3× (100 mg artesunate +250 mg mefloquine)) combined with praziquantel (40 mg/kg) (treatments administered on subsequent days). Two urine samples were collected before, and on days 21–22 and 78–79 after the first dosing. Principal Findings Sixty-one children were present on all examination time points and had complete datasets. No difference in efficacy was observed between the three treatment groups on either follow-up. On the 21–22 day posttreatment follow-up, based on available case analysis, cure rates of 33% (95% confidence interval (CI) 11–55%), 29% (95% CI 8–50%), and 26% (95% CI 5–48%) were observed for praziquantel, mefloquine-artesunate-praziquantel, and mefloquine-praziquantel, respectively. The corresponding egg reduction rates were 94% and above. On the second follow-up, observed cure rates ranged from 19% (praziquantel) to 33% (mefloquine-artesunate-praziquantel), and egg reduction rates were above 90%. Praziquantel monotherapy was the best tolerated treatment. In the mefloquine-artesunate-praziquantel group, adverse events were reported by 91% of the participants, and in the mefloquine-praziquantel group, 95% experienced adverse events. With the exception of abdominal pain at moderate severity, adverse events were mild. Conclusions/Significance The addition of mefloquine or mefloquine-artesunate does not increase the efficacy of praziquantel against chronic S. haematobium infection. Additional studies are necessary to elucidate the effect of the combinations against acute schistosomiasis. PMID:25033291

Keiser, Jennifer; Silue, Kigbafori D.; Adiossan, Lukas K.; N'Guessan, Nicaise A.; Monsan, N'Chou; Utzinger, Jurg; N'Goran, Eliezer K.

2014-01-01

2

Determination of ED 50 values for praziquantel in praziquantel-resistant and -susceptible Schistosoma mansoni isolates  

Microsoft Academic Search

The dose of praziquantel required to kill 50% of adult worms in vivo (i.e. the ED50) was estimated for nine different isolates of Schistosoma mansoni in infected mice. Four of the isolates were selected because they had not knowingly been in contact with the drug (i.e. they were putatively praziquantel-susceptible). Five putatively praziquantel-resistant isolates were chosen because they had been

Donato Cioli; Sanaa S Botros; Katherine Wheatcroft-Francklow; Amadou Mbaye; Vaughan Southgate; Louis-Albert Tchuem Tchuenté; Livia Pica-Mattoccia; Anna Rita Troiani; Sayed H Seif el-Din; Abdel-Nasser A Sabra; Jan Albin; Dirk Engels; Michael J Doenhoff

2004-01-01

3

Metabolic profiling of praziquantel enantiomers.  

PubMed

Praziquantel (PZQ), prescribed as a racemic mixture, is the most readily available drug to treat schistosomiasis. In the present study, ultra-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass spectrometry (UPLC-ESI-QTOFMS) based metabolomics was employed to decipher the metabolic pathways and enantioselective metabolic differences of PZQ. Many phase I and four new phase II metabolites were found in urine and feces samples of mice 24h after dosing, indicating that the major metabolic reactions encompassed oxidation, dehydrogenation, and glucuronidation. Differences in the formation of all these metabolites were observed between (R)-PZQ and (S)-PZQ. In an in vitro phase I incubation system, the major involvement of CYP3A, CYP2C9, and CYP2C19 in the metabolism of PZQ, and CYP3A, CYP2C9, and CYP2C19 exhibited different catalytic activity toward the PZQ enantiomers. Apparent Km and Vmax differences were observed in the catalytic formation of three mono-oxidized metabolites by CYP2C9 and CYP3A4 further supporting the metabolic differences for PZQ enantiomers. Molecular docking showed that chirality resulted in differences in substrate location and conformation, which likely accounts for the metabolic differences. In conclusion, in silico, in vitro, and in vivo methods revealed the enantioselective metabolic profile of praziquantel. PMID:24821110

Wang, Haina; Fang, Zhong-Ze; Zheng, Yang; Zhou, Kun; Hu, Changyan; Krausz, Kristopher W; Sun, Dequn; Idle, Jeffrey R; Gonzalez, Frank J

2014-07-15

4

Praziquantel Treatment in Trematode and Cestode Infections: An Update  

PubMed Central

Status and emerging issues in the use of praziquantel for treatment of human trematode and cestode infections are briefly reviewed. Since praziquantel was first introduced as a broadspectrum anthelmintic in 1975, innumerable articles describing its successful use in the treatment of the majority of human-infecting trematodes and cestodes have been published. The target trematode and cestode diseases include schistosomiasis, clonorchiasis and opisthorchiasis, paragonimiasis, heterophyidiasis, echinostomiasis, fasciolopsiasis, neodiplostomiasis, gymnophalloidiasis, taeniases, diphyllobothriasis, hymenolepiasis, and cysticercosis. However, Fasciola hepatica and Fasciola gigantica infections are refractory to praziquantel, for which triclabendazole, an alternative drug, is necessary. In addition, larval cestode infections, particularly hydatid disease and sparganosis, are not successfully treated by praziquantel. The precise mechanism of action of praziquantel is still poorly understood. There are also emerging problems with praziquantel treatment, which include the appearance of drug resistance in the treatment of Schistosoma mansoni and possibly Schistosoma japonicum, along with allergic or hypersensitivity reactions against praziquantel treatment. To cope with and overcome these problems, combined use of drugs, i.e., praziquantel and other newly introduced compounds such as triclabendazole, artemisinins, and tribendimidine, is being tried. PMID:24265948

2013-01-01

5

21 CFR 520.903d - Febantel-praziquantel paste.  

Code of Federal Regulations, 2012 CFR

...milligram of praziquantel per kilogram of body weight (1 gram of paste per 7.5 pounds body weight) administered by mouth or in the food once...milligrams of praziquantel per kilogram of body weight (1 gram of paste per 5 pounds body...

2012-04-01

6

In vitro uptake of /sup 14/C-praziquantel by cestodes, trematodes, and a nematode  

SciTech Connect

/sup 14/C-praziquantel was rapidly taken up by Schistosoma mansoni, Fasciola hepatica, Hymenolepis nana, and isolated strobilocerci of Taenia taeniaeformis. Schistosoma mansoni lost praziquantel rapidly to drug-free medium. Chromatography of extracts prepared after incubation of S. mansoni and H. nana yielded no indication that praziquantel was metabolized. Autoradiography revealed a uniform distribution of praziquantel throughout the tissues of S. mansoni and H. nana. Uptake was considerably slower in the nematode Heterakis spumosa and apparently via the oral route.

Andrews, P.; Thomas, H.; Weber, H.

1980-12-01

7

UMA ANÁLISE DO CUSTO DE VIAGEM PARA A PRAIA DA AVENIDA EM MACEIÓ  

Microsoft Academic Search

A cidade de Maceió em Alagoas constitui uma cidade litorânea da Região Nordeste do Brasil dotada de beleza natural tais como praias e lagoas, as quais constituem atrativos para o turismo tanto nacional como internacional. Todavia, nesta o crescimento do setor turístico tem sido afetado pela poluição dos recursos ambientais, mais especificamente o despejo do esgoto em praias e lagoas.

Eliane Aparecida Pereira De Abreu; Agnaldo Gomes da Silva; Gilberto Gomes Da Silva Junior; Rebecca Suzannah Nascimento De Melo

2008-01-01

8

21 CFR 520.903d - Febantel-praziquantel paste.  

Code of Federal Regulations, 2010 CFR

...milligrams of praziquantel per kilogram of body weight (1 gram of paste per 5 pounds body weight) administered by mouth on a full stomach once daily for 3 days. (2) Indications for use. (i) Dogs and puppies: For removal of hookworms (Ancylostoma...

2010-04-01

9

21 CFR 520.903d - Febantel-praziquantel paste.  

Code of Federal Regulations, 2011 CFR

...PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.903d Febantel-praziquantel...Limitations. Do not use in pregnant animals. Federal law restricts this...considerations. Consider alternative therapy or use with caution in animals with pre-existing liver...

2011-04-01

10

21 CFR 520.903d - Febantel-praziquantel paste.  

Code of Federal Regulations, 2013 CFR

...PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.903d Febantel-praziquantel...Limitations. Do not use in pregnant animals. Federal law restricts this...considerations. Consider alternative therapy or use with caution in animals with pre-existing liver...

2013-04-01

11

Efficacy of praziquantel against Schistosoma mansoni in northern Senegal  

Microsoft Academic Search

Two treatments with praziquantel (PZQ) 40 mg\\/kg, 40 d apart, were given to individuals in a recently established (< 6 years) Schistosoma mansoni focus in the Senegal River Basin (SKB). Efficacy of treatment was evaluated 4 weeks after each treatment. Among 130 individuals who provided stool samples on days 0, 118 and 153 and were treated on days 85 and

Michel Picquet; Jozef Vercruysse; Darren J. Shaw; Mamadou Diop; Abdoulaye Ly

1998-01-01

12

A caminho do topo Criar em Portugal uma universidade de dimenso mdia no plano europeu,  

E-print Network

Lisboa (a antiga "Cl�ssica") e T�cnica de Lisboa teve o objetivo de criar uma nova institui��o: a maior (a antiga "Cl�ssica") com a Universidade T�cnica de Lisboa. Que cuidados foram necess�rios ter em

Instituto de Sistemas e Robotica

13

ARALES DE LAGOAS EM UMA ÁREA DO SEMI-ÁRIDO BAIANO  

Microsoft Academic Search

RESUMO — O presente trabalho trata das espécies de Arales ocorrentes em lagoas de uma área do semi-árido baiano. A ordem apresenta, no local, duas famílias com cinco espécies: Lemna valdiviana Phil., Lemna aequinoctialis Welwitsch, Wolffiella lingulata (Hegelm.) Hegelm. e Wolffia columbiana Karsten (LEMNACEAE) e Pistia stratiotes L. (ARACEAE). PALAVRAS-CHAVE: Arales; plantas aquáticas; Lemnaceae; Araceae. ABSTRACT — This paper presents

Márcia Gonçalves Bezerra; Flávio França

14

Praziquantel efficacy against schistosomiasis mansoni in schoolchildren in north-west Ethiopia.  

PubMed

The efficacy of praziquantel against schistosomiasis mansoni has been measured in 10-14 years old schoolchildren in a highly endemic area of north-west Ethiopia. The egg reduction rate was 97% and the cure rate was 94%, as assessed by a single Kato smear. No evidence for praziquantel resistance was detected. PMID:12497985

Degu, Getinet; Mengistu, Getahun; Jones, Janet

2002-01-01

15

DIVISÃO DE TRABALHO E RELAÇAO DE GÊNERO EM COMUNIDADES AMAZÔNICAS: UMA REALIDADE EM TRANSFORMAÇÃO  

Microsoft Academic Search

As relações de gênero constituem o conjunto das relações sociais e econômicas no universo do trabalho, da cultura e da política. Está organizada a partir dos papéis masculinos e femininos dentro de estruturas que permanecem constantes em algumas sociedades ou de forma presente no inconsciente social que às vezes é refletido em ações do cotidiano colocando cada agente social dentro

Albejamere Pereira de Castro

16

Uma comparação entre técnicas de propagação de erros em astrofísica: Monte Carlo x Bootstrap  

NASA Astrophysics Data System (ADS)

Recentemente Dhillon & Watson (2001) criticaram o procedimento de determinação de erros via simulações de Monte Carlo no caso do imageamento indireto de estrelas, por introduzir ruído nos dados e resultar em erros superestimados. Estes autores propuseram a utilização alternativa do método de Bootstrap como uma técnica superior para a estimativa de erros. Neste trabalho apresentamos os resultados de um estudo comparativo da performance das técnicas de simulação por Monte Carlo e por Bootstrap para a determinação de erros em duas situações de interesse: (i) ajuste de modelos a espectros observados e (ii) imageamento indireto de discos de acréscimo com técnicas de mapeamento por eclipse. No caso (i), os dados de entrada são espectros de emissão simples de hidrogênio aos quais é adicionado ruído gaussiano de amplitude selecionada. No caso (ii), são produzidas curvas de luz do eclipse de uma distribuição de brilho seguindo a lei TµR-3/4 para discos estacionários cuja taxa de acréscimo varia ao longo do eclipse segundo uma distribuição gaussiana de amplitude selecionada, simulando o ruído. A avaliação da performance é feita com o auxílio de um diagrama do erro relativo na grandeza ajustada, conforme obtido por cada método, versus o erro relativo (ruído/sinal) dos dados de entrada. O estudo mostra que as duas técnicas produzem resultados semelhantes nos dois casos, e que a suposta superioridade do método de Bootstrap não se confirma.

Waelkens, A. H.; Janot Pacheco, E.

2003-08-01

17

Evidence against rapid emergence of praziquantel resistance in Schistosoma haematobium, Kenya.  

PubMed Central

We examined the long-term efficacy of praziquantel against Schistosoma haematobium, the causative agent of urinary schistosomiasis, during a school-based treatment program in the Msambweni area of Coast Province, Kenya, where the disease is highly endemic. Our results, derived from treating 4,031 of 7,641 children from 1984 to 1993, indicate substantial year-to- year variation in drug efficacy. However, the pattern of this variation was not consistent with primary or progressive emergence of praziquantel resistance. Mathematical modeling indicated that, at current treatment rates, praziquantel resistance will likely take 10 or more years to emerge. PMID:11076716

King, C. H.; Muchiri, E. M.; Ouma, J. H.

2000-01-01

18

The Acute Toxicity of Praziquantel to Grass Carp and Golden Shiners  

Microsoft Academic Search

The acute toxicity and highest nonlethal concentration of praziquantel (LC0) were determined in the laboratory for grass carp Ctenopharyngodon idella and golden shiner Notemigonus crysoleucas, two cyprinids known to harbor the Asian tapeworm Bothriocephalus acheilognathi. Praziquantel is an anthelmintic used to treat fish with tapeworms. The 24-h and 96-h LC50 values were 55.1 and 49.7 mg\\/L for golden shiners (1.3

Andrew J. Mitchell; Melissa S. Hobbs

2007-01-01

19

Comparison of albendazole, mebendazole and praziquantel chemotherapy of Echinococcus multilocularis in a gerbil model  

Microsoft Academic Search

The efficacy of albendazole (50 mg\\/kg\\/d), mebendazole (50 mg\\/kg\\/d) and praziquantel (500 mg\\/kg\\/d) against established intraperitoneal infections of Echinococcus multilocularis in gerbils was compared by monitoring parasite weight and making ultrastructural observations on treated and untreated material. Praziquantel was the most active protoscolicidal agent, reducing protoscolex viability to less than 2%, although it did not inhibit cyst growth. Albendazole was

D H Taylor; D L Morris; D Reffin; K S Richards

1989-01-01

20

Praziquantel synergistically enhances paclitaxel efficacy to inhibit cancer cell growth.  

PubMed

The major challenges we are facing in cancer therapy with paclitaxel (PTX) are the drug resistance and severe side effects. Massive efforts have been made to overcome these clinical challenges by combining PTX with other drugs. In this study, we reported the first preclinical data that praziquantel (PZQ), an anti-parasite agent, could greatly enhance the anticancer efficacy of PTX in various cancer cell lines, including PTX-resistant cell lines. Based on the combination index value, we demonstrated that PZQ synergistically enhanced PTX-induced cell growth inhibition. The co-treatment of PZQ and PTX also induced significant mitotic arrest and activated the apoptotic cascade. Moreover, PZQ combined with PTX resulted in a more pronounced inhibition of tumor growth compared with either drug alone in a mouse xenograft model. We tried to investigate the possible mechanisms of this synergistic efficacy induced by PZQ and PTX, and we found that the co-treatment of the two drugs could markedly decrease expression of X-linked inhibitor of apoptosis protein (XIAP), an anti-apoptotic protein. Our data further demonstrated that down-regulation of XIAP was required for the synergistic interaction between PZQ and PTX. Together, this study suggested that the combination of PZQ and PTX may represent a novel and effective anticancer strategy for optimizing PTX therapy. PMID:23251610

Wu, Zhen Hua; Lu, Ming-ke; Hu, Long Yu; Li, Xiaotong

2012-01-01

21

Ca²? channels and praziquantel: a view from the free world.  

PubMed

Targeting the cellular Ca(2+) channels and pumps that underpin parasite Ca(2+) homeostasis may realize novel antihelmintic agents. Indeed, the antischistosomal drug praziquantel (PZQ) is a key clinical agent that has been proposed to work in this manner. Heterologous expression data has implicated an action of PZQ on voltage-operated Ca(2+) channels, although the relevant in vivo target of this drug has remained undefined over three decades of clinical use. The purpose of this review is to bring new perspective to this issue by discussing the potential utility of free-living planarian flatworms for providing new insight into the mechanism of PZQ action. First, we discuss in vivo functional genetic data from the planarian system that broadly supports the molecular data collected in heterologous systems and the 'Ca(2+) hypothesis' of PZQ action. On the basis of these similarities we highlight our current knowledge of platyhelminth voltage operated Ca(2+) channels, their unique molecular pharmacology and the downstream functional PZQ interactome engaged by dysregulation of Ca(2+) influx that has potential to yield novel antischistosomal targets. Overall the broad dataset underscores a common theme of PZQ-evoked disruptions of Ca(2+) homeostasis in trematodes, cestodes and turbellarians, and showcases the utility of the planarian model for deriving insight into drug action and targets in parasitic flatworms. PMID:23246536

Chan, John D; Zarowiecki, Magdalena; Marchant, Jonathan S

2013-12-01

22

Praziquantel Treatment Decreases Schistosoma mansoni Genetic Diversity in Experimental Infections  

PubMed Central

Background Schistosomiasis has a considerable impact on public health in many tropical and subtropical areas. In the new world, schistosomiasis is caused by the digenetic trematode Schistosoma mansoni. Chemotherapy is the main measure for controlling schistosomiasis, and the current drug of choice for treatment is praziquantel (PZQ). Although PZQ is efficient and safe, its repetitive large-scale use in endemic areas may lead to the selection of resistant strains. Isolates less susceptible to PZQ have been found in the field and selected for in the laboratory. The impact of selecting strains with a decreased susceptibility phenotype on disease dynamics and parasite population genetics is not fully understood. This study addresses the impact of PZQ pressure on the genetics of a laboratory population by analyzing frequency variations of polymorphic genetic markers. Methodology Infected mice were treated with increasing PZQ doses until the highest dose of 3×300 mg/Kg was reached. The effect of PZQ treatment on the parasite population was assessed using five polymorphic microsatellite markers. Parasitological and genetic data were compared with those of the untreated control. After six parasite generations submitted to treatment, it was possible to obtain a S. mansoni population with decreased susceptibility to PZQ. In our experiments we also observed that female worms were more susceptible to PZQ than male worms. Conclusions The selective pressure exerted by PZQ led to decreased genetic variability in S. mansoni and increased endogamy. The understanding of how S. mansoni populations respond to successive drug pressure has important implications on the appearance and maintenance of a PZQ resistance phenotype in endemic regions. PMID:24367712

Coeli, Regina; Baba, Elio H.; Araujo, Neusa; Coelho, Paulo M. Z.; Oliveira, Guilherme

2013-01-01

23

75 FR 54018 - Oral Dosage Form New Animal Drugs; Praziquantel and Pyrantel  

Federal Register 2010, 2011, 2012, 2013

The Food and Drug Administration (FDA) is amending the animal drug regulations to reflect approval of a supplemental new animal drug application (NADA) filed by Bayer HealthCare LLC. The supplement provides for two new sizes of praziquantel and pyrantel pamoate tablets used in cats and kittens for the removal of various internal parasites and for a revised kitten age and weight...

2010-09-03

24

SHORT REPORT: FAILURE OF STANDARD TREATMENT WITH PRAZIQUANTEL IN TWO RETURNED TRAVELERS WITH SCHISTOSOMA HAEMATOBIUM INFECTION  

Microsoft Academic Search

A single 40 mg\\/kg dose of praziquantel (PZQ) continues to be the standard treatment for schistosomiasis caused by S. mansoni and S. haematobium in all clinical settings. Experimental development of drug resistance and the recent isolation of S. mansoni strains with a natural tolerance to high doses of PZQ have raised concerns over the adequacy of such a dose. We

DAVID ALONSO; JOSE MUÑOZ; JOAQUIM GASCÓN; MARIA EUGENIA VALLS; MANUEL CORACHAN

2006-01-01

25

Efficacy of artemether and artesunate in mice infected with praziquantel non-susceptible isolate of Schistosoma japonicum.  

PubMed

Praziquantel is currently the only drug of choice for the treatment of human Schistosoma japonicum infections, and praziquantel-based chemotherapy has been proved to be generally effective to control the morbidity and reduce the prevalence and intensity of S. japonicum infections. However, the potential emergence of praziquantel resistance in S. japonicum seriously threatens the elimination of this neglected tropical disease in China. The purpose of this study was designed, in mouse animals, to evaluate the in vivo efficacy of artemether and artesunate against praziquantel non-susceptible S. japonicum. Mice infected with a praziquantel non-susceptible isolate and a praziquantel-susceptible isolate of S. japonicum were treated with artemether and artesunate at a single oral dose of 300 mg/kg given once on each of days 7-8 and 35-36 post-infection to assess the efficacy against juvenile and adult worms. Administration with artemether and artesunate at a single oral dose of 300 mg/kg on each of days 7-8 post-infection resulted in total worm burden reductions of 72.8 and 73.5% in mice infected with praziquantel-susceptible S. japonicum, and 77.9 and 74.1% in mice infected with the non-susceptible isolate (both P values >0.05), while the same treatments given on days 35-36 post-infection reduced total worm burdens by 71.4 and 69.6% in mice infected with the susceptible isolate, and 75.3 and 69.6% in mice infected with the non-susceptible parasite (both P values >0.05). It is concluded that there is no evidence for reduced susceptibility of artemether and artesunate in praziquantel non-susceptible S. japonicum. PMID:24326467

Wang, Wei; Li, Tian-Yu; Ji, Yuan; Qu, Guo-Li; Qian, Yi-Li; Li, Hong-Jun; Dai, Jian-Rong; Liang, You-Sheng

2014-03-01

26

Efficacy of praziquantel (Cesocide injection) in treatment of cestode infections in domestic and laboratory animals.  

PubMed

Efficacy of praziquantel (Cesocide injection) by intramuscular (I.M.) route against cestode infections was evaluated. Total 93 domestic or laboratory animals such as dogs, cats, rats, mice, goats, deers and chickens were used. Animals were infected with Dipylidium caninum, Spirometra sp., Taenia pisiformis, Taenia taeniaeformis, Hymenolepis nana, Moniezia expansa, Moniezia sp. or Raillietina sp. A single dose of praziquantel, 6 mg/kg of body weight, was highly effective (97.9%) against cestodes of various kinds disregarding the host species or their intensity of infection. At high dose above 6 mg/kg, the cure rate was 100%. All the cestodes treated were expelled from the host within 48 hours. The discharged proglottids were damaged severely except Hymenolepis nana and Moniezia expansa. Intramuscular injection of this drug evoked a brief pain response in a dog, but no other side reactions were observed. PMID:12811058

Eom, Kee Seon; Kim, Seung Ho; Rim, Han Jong

1988-06-01

27

Queda dos homic?dios em S?o Paulo, Brasil: uma an?lise descritiva  

PubMed Central

Objetivo Descrever a evolução da mortalidade por homicídios no Município de São Paulo segundo tipo de arma, sexo, raça ou cor, idade e áreas de exclusão/inclusão social entre 1996 e 2008. Métodos Estudo ecológico de série temporal. Os dados sobre óbitos ocorridos no Município foram coletados da base de dados do Programa de Aprimoramento das Informações sobre Mortalidade, seguindo a Classificação Internacional de Doenças, Décima Revisão (CID-10). Foram calculadas as taxas de mortalidade por homicídio (TMH) para a população total, por sexo, raça ou cor, faixa etária, tipo de arma e área de exclusão/inclusão social. As TMH foram padronizadas por idade pelo método direto. Foram calculados os percentuais de variação no período estudado. Para as áreas de exclusão/inclusão social foram calculados os riscos relativos de morte por homicídio. Resultados As TMH apresentaram queda de 73,7% entre 2001 e 2008. Foi observada redução da TMH em todos os grupos analisados, mais pronunciada em homens (?74,5%), jovens de 15 a 24 anos (?78,0%) e moradores de áreas de exclusão social extrema (?79,3%). A redução ocorreu, sobretudo, nos homicídios cometidos com armas de fogo (?74,1%). O risco relativo de morte por homicídio nas áreas de exclusão extrema (tendo como referência áreas com algum grau de exclusão social) foi de 2,77 em 1996, 3,9 em 2001 e 2,13 em 2008. Nas áreas de alta exclusão social, o risco relativo foi de 2,07 em 1996 e 1,96 em 2008. Conclusões Para compreender a redução dos homicídios no Município, é importante considerar macrodeterminantes que atingem todo o Município e todos os subgrupos populacionais e microdeterminantes que atuam localmente, influenciando de forma diferenciada os homicídios com armas de fogo e os homicídios na população jovem, no sexo masculino e em residentes em áreas de alta exclusão social. PMID:21390415

Peres, Maria Fernanda Tourinho; Vicentin, Diego; Nery, Marcelo Batista; de Lima, Renato Sergio; de Souza, Edinilsa Ramos; Cerda, Magdalena; Cardia, Nancy; Adorno, e Sergio

2012-01-01

28

Efficacy and Safety of Praziquantel, Tribendimidine and Mebendazole in Patients with Co-infection of Clonorchis sinensis and Other Helminths  

PubMed Central

Background Both tribendimidine and mebendazole are broad-spectrum drugs for anti-intestinal nematodes. We aim to assess the efficacy and safety of tribendimidine and mebendazole in patients with co-infection of Clonorchis sinensis and other helminths. Method We performed a randomized open-label trial in Qiyang, People's Republic of China. Eligible participants were randomly assigned to one of four groups: (i) a single dose of 400 mg tribendimidine, (ii) 200 mg tribendimidine twice daily, (iii) 75 mg/kg praziquantel divided in four doses within 2 days, and (iv) a single dose of 400 mg mebendazole. Cure rates and egg reduction rates were assessed, and adverse events were monitored after treatments. Uncured patients accepted the second treatment with the same drugs after the first treatment. Results 156 patients were eligible for the study. Results from the first treatment showed that the cure rates of single-dose tribendimidine and praziquantel against C. sinensis were 50% and 56.8%, respectively; the single-dose tribendimidine achieved the cure rate of 77.8% in the treatment for hookworm, which was significantly higher than that of praziquantel; Low cure rates were obtained in the treatment of single-dose tribendimidine against Ascaris lumbricoides and Trichuris trichiura (28.6% and 23.1%). Results of the second treatment illustrated the cure rates of tribendimidine and praziquantel against C. sinensis were 78.1% and 75%, respectively. Most adverse events were mild and transient. Adverse events caused by tribendimidine were significantly less than praziquantel. Conclusion Single-dose tribendimidine showed similar efficacy against C. sinensis as praziquantel with less adverse events, and achieved significantly higher cure rate in the treatment for hookworm than those of praziquantel and mebendazole. Low cure rates, which were still higher than other drugs, were obtained in the treatment of single-dose tribendimidine against Ascaris lumbricoides and Trichuris trichiura. Trial Registration Controlled-Trials.com ISRCTN55086560 PMID:25122121

Xu, Li-Li; Jiang, Bin; Duan, Ji-Hui; Zhuang, Shi-Feng; Liu, Yong-Chun; Zhu, Shi-Qiao; Zhang, Li-Ping; Zhang, Hao-Bing; Xiao, Shu-Hua; Zhou, Xiao-Nong

2014-01-01

29

Comparative efficacy of a spot-on formulation containing emodepside and praziquantel (Profender ®, Bayer) and praziquantel and pyrantel oral tablets (Drontal ® for Cats) against experimental Ancylostoma ceylanicum infections in cats.  

PubMed

Ancylostoma ceylanicum is a common zoonotic hookworm of dogs and cats throughout Asia and has also been reported to occur within the Australasian region. The aim of this study to was to determine the efficacy of a spot-on formulation containing emodepside and praziquantel (Profender(®), Bayer) and praziquantel and pyrantel oral tablets (Drontal(®) for Cats, Bayer) against experimental A. ceylanicum infections in cats. Twenty-four kittens were each subcutaneously injected with 100 infective third-stage larvae of A. ceylanicum. Kittens were stratified by egg count and randomly allocated equally into control and two treatment groups. The first group were treated with emodepside 2.1%/praziquantel 8.6% (Profender®, Bayer) at the recommended label dose. The second group was treated with 80 mg pyrantel and 20mg praziquantel (Drontal(®) for Cats, Bayer) at the recommended label dose. The kittens in the control group were not treated. Egg counts were performed daily until the end of the study period and compared for the treated and control groups. No eggs were detected in the treated group of kittens within 4 days of treatment and faecal samples from this group remained negative throughout the rest of the study, resulting in a treatment efficacy (egg reduction) of 100% (P<0.0001). The egg counts remained high (993 ± 666 epg) in the untreated control group for the rest of the study period. This study demonstrated that both combination products containing topical emodepside/praziquantel (Profender(®), Bayer) and praziquantel/pyrantel oral tablets (Drontal(®) for Cats, Bayer) given at the recommended dose is highly effective against infection with A. ceylanicum in cats. PMID:23026558

Taweethavonsawat, Piyanan; Chungpivat, Sudchit; Watanapongchati, Supoj; Traub, Rebecca J; Schaper, Roland

2013-01-16

30

Avaliação Antropométrica em Estudantes de uma Comunidade Litorânea de Camaçari, Bahia Avaliação Antropométrica em Estudantes de uma Comunidade Litorânea de Camaçari, Bahia Avaliação Antropométrica em Estudantes de uma Comunidade Litorânea de Camaçari, Bahia Avaliação Antropométrica em Estudantes de uma Comunidade Litorânea de Camaçari, Bahia Avaliação Antropométrica em Estudantes de uma Comunidade Litorânea de Camaçari, Bahia Anthropometric Evaluation of Students from a Coastal Community in Camaçari, Bahia  

Microsoft Academic Search

A avaliação antropométrica faz parte dos cuidados pediátricos de rotina e é um dos indicadores mais sensíveis de saúde da criança, devido a sua maior facilidade de execução, rapidez e baixo custo. Objetivo: realizar o estudo antropométrico de estudantes de uma comunidade litorânea do Nordeste brasileiro, onde a desnutrição se mantém como importante problema de saúde pública. Material e Métodos:

Caroline O. Kupsch; Danilo A. Badaró; Larissa V. C. Zugaib

2007-01-01

31

Anthelmintic efficacy of febantel combined with praziquantel against Ancylostoma tubaeforme, Toxocara cati, and Taenia taeniaeformis in cats.  

PubMed

Forty cats, each harboring 2 or 3 parasitic infections (Ancylostoma tubaeforme, Toxocara cati, and/or Taenia taeniaeformis), were used to titrate the anthelmintic efficacy of a paste containing 3.4% febantel and 0.34% praziquantel. The cats were allotted into 4 groups (10 cats/group). For 3 consecutive days, the cats were given febantel/praziquantel at 5/0.5 mg/kg/day, 10/1 mg/kg/day, 15/1.5 mg/kg/day, or a blank paste vehicle (control) at 0.29 g/kg of body weight. The recommended dosage of 10 mg of febantel and 1 mg of praziquantel/kg cleared greater than or equal to 98% of the 3 helminth species. PMID:3767110

Arther, R G; Cox, D D

1986-09-01

32

Development of antischistosomal drugs in China, with particular consideration to praziquantel and the artemisinins.  

PubMed

Remarkable achievements have been made in the control of schistosomiasis in China, with chemotherapy playing a seminal role. From the early 1950s through the early 1980s, Chinese scientists made considerable progress in discovery and development of compounds with antischistosomal properties, including antimonials, non-antimonials and various effective principles stemming from traditional herbs. However, only few compounds entered clinical testing, while others were abandoned mainly due to their toxicity and poor efficacy. The advent of praziquantel in the 1970s changed the landscape of research and development of drugs for treatment and morbidity control of schistosomiasis. The main Chinese contributions to enhance the understanding of the antischistosomal drug praziquantel are reviewed here, including issues of metabolism, antibody-dependency, host immune factors, stage-specific susceptibility and resistance. Over the past 25 years, researchers from China successfully developed artemether and artesunate, two derivatives from the antimalarial artemisinin, as promising drugs against Schistosoma japonicum. Laboratory investigations showed that the artemisinins display their highest activity against the juvenile stages of the parasite. These findings were consistently confirmed in randomised controlled trials; repeated oral administration of artemether or artesunate was safe and efficacious in the prevention of patent S. japonicum infections. The key findings are reviewed here, and emphasis is placed on how it stimulated research outside of China on other human schistosome species. PMID:16112072

Xiao, Shu-Hua

2005-01-01

33

Cytokine Pattern of T Lymphocytes in Acute Schistosomiasis mansoni Patients following Treated Praziquantel Therapy  

PubMed Central

Acute schistosomiasis is associated with a primary exposure and is more commonly seen in nonimmune individuals traveling through endemic regions. In this study, we have focused on the cytokine profile of T lymphocytes evaluated in circulating leukocytes of acute Schistosomiasis mansoni-infected patients (ACT group) before and after praziquantel treatment (ACT-TR group). Our data demonstrated increased values of total leukocytes, eosinophils, and monocytes in both groups. Interestingly, we have observed that patients treated with praziquantel showed increased values of lymphocytes as compared with noninfected group (NI) or ACT groups. Furthermore, a decrease of neutrophils in ACT-TR was observed when compared to ACT group. Analyses of short-term in vitro whole blood stimulation demonstrated that, regardless of the presence of soluble Schistosoma mansoni eggs antigen (SEA), increased synthesis of IFN-? and IL-4 by T-cells was observed in the ACT group. Analyses of cytokine profile in CD8 T cells demonstrated higher percentage of IFN-? and IL-4 cells in both ACT and ACT-TR groups apart from increased percentage of IL-10 cells only in the ACT group. This study is the first one to point out the relevance of CD8 T lymphocytes in the immune response induced during the acute phase of schistosomiasis. PMID:23401741

Silveira-Lemos, Denise; Fernandes Costa-Silva, Matheus; Cardoso de Oliveira Silveira, Amanda; Azevedo Batista, Mauricio; Alves Oliveira-Fraga, Lucia; Soares Silveira, Alda Maria; Barbosa Alvarez, Maria Carolina; Martins-Filho, Olindo Assis; Gazzinelli, Giovanni; Correa-Oliveira, Rodrigo; Teixeira-Carvalho, Andrea

2013-01-01

34

Five-year impact of repeated praziquantel treatment on subclinical morbidity due to Schistosoma japonicum in China  

Microsoft Academic Search

We report the 5-year impact (1996–2001) of repeated praziquantel chemotherapy on subclinical morbidity related to Schistosoma japonicum infection. We repeated stool examinations and hepatosplenic ultrasonography in a cohort of 120 individuals living on an island with endemic infection in Dongting Lake, China. Prevalence of schistosome infection fell by 43% and intensity (geometric mean eggs per gram) declined by 80% over

Y. S. Li; A. C. Sleigh; M. Tanner; A. Dessein; G. M. Williams; D. P. McManus

2002-01-01

35

Comparative clinical studies of nitazoxanide, albendazole and praziquantel in the treatment of ascariasis, trichuriasis and hymenolepiasis in children from Peru  

Microsoft Academic Search

Three randomized clinical studies were conducted in 2000 to evaluate the efficacy of nitazoxanide paediatric suspension compared to albendazole in the treatment of ascariasis and trichuriasis and praziquantel in the treatment of hymenolepiasis in children from Cajamarca, Peru. Nitazoxanide was administered at a dose of 100 mg (age 1–3 years) or 200 mg (age 4–11 years) twice daily for 3

Juan Jave Ortiz; Nicholas Lopez Chegne; Gilles Gargala; Loic Favennec

2002-01-01

36

Efficacy of praziquantel and artemisinin derivatives for the treatment and prevention of human schistosomiasis: a systematic review and meta-analysis  

PubMed Central

Background Praziquantel has been used as first-line drug for chemotherapy of schistosomiasis since 1984. Besides praziquantel, artemether and artesunate have also been used for the control of this infectious disease since late 1990s. In this article, we conducted a systematic review and meta-analysis to evaluate the antischistosomal efficacy of different medication strategies including monotherapy or combination therapies of these drugs. Results A number of 52 trials from 38 articles published in peer-reviewed journals before July 2011 were selected for analysis after searching the following literature databases: the Cochrane Library, PubMed/Medline, ISI Web of Science, Chinese Biomedicine Literature Database, and China National Knowledge Infrastructure. Our meta-analyses showed that a dosage of 30-60 mg/kg praziquantel compared with placebo produced a protection rate of about 76% (95% CI: 67%-83%) for treating human schistosomiasis, which varied from 70% to 76% with no significant differences among the subspecies S. haematobium, S. japonicum or S. mansoni. Protection rates were higher when praziquantel doses were elevated, as concluded from the nRCTs results: the protection rate of praziquantel at 40 mg/kg was 52% (95% CI: 49%-55%), and it increased to 91% (95% CI: 88%-92%) when the dosages were elevated to 60/80/100 mg/kg divided two or more doses. Multiple doses of artemether or artesunate over 1- or 2-week intervals resulted in protection rates of 65% to 97% for preventing schistosomiasis, and increased doses and shorter medication intervals improved their efficacies. Praziquantel and artemisinin derivatives (artemether or artesunate) in combination resulted in a higher protection rate of 84% (95% CI: 64%-91%) than praziquantel monotherapy for treatment. praziquantel and artesunate in combination had a great protection rate of 96% (95% CI: 78%-99%) for preventing schistosomes infection. Conclusions According to the results, praziquantel remains effective in schistosomiasis treatment, and multiple doses would improve its efficacy; meanwhile, praziquantel is also a good drug for preventing acute schistosomiasis morbidity. It's better to use multiple doses of artemether or artesunate with 1- or 2-week intervals for prevention against schistosome infection. Praziquantel and artemether or artesunate in combination perform better in treatment than praziquantel monotherapy, and they are especially suitable for treating the patients with repeated exposure to infected water. PMID:22004571

2011-01-01

37

A Novel Biological Activity of Praziquantel Requiring Voltage-Operated Ca2+ Channel ? Subunits: Subversion of Flatworm Regenerative Polarity  

PubMed Central

Background Approximately 200 million people worldwide harbour parasitic flatworm infections that cause schistosomiasis. A single drug—praziquantel (PZQ)—has served as the mainstay pharmacotherapy for schistosome infections since the 1980s. However, the relevant in vivo target(s) of praziquantel remain undefined. Methods and Findings Here, we provide fresh perspective on the molecular basis of praziquantel efficacy in vivo consequent to the discovery of a remarkable action of PZQ on regeneration in a species of free-living flatworm (Dugesia japonica). Specifically, PZQ caused a robust (100% penetrance) and complete duplication of the entire anterior-posterior axis during flatworm regeneration to yield two-headed organisms with duplicated, integrated central nervous and organ systems. Exploiting this phenotype as a readout for proteins impacting praziquantel efficacy, we demonstrate that PZQ-evoked bipolarity was selectively ablated by in vivo RNAi of voltage-operated calcium channel (VOCC) ? subunits, but not by knockdown of a VOCC ? subunit. At higher doses of PZQ, knockdown of VOCC ? subunits also conferred resistance to PZQ in lethality assays. Conclusions This study identifies a new biological activity of the antischistosomal drug praziquantel on regenerative polarity in a species of free-living flatworm. Ablation of the bipolar regenerative phenotype evoked by PZQ via in vivo RNAi of VOCC ? subunits provides the first genetic evidence implicating a molecular target crucial for in vivo PZQ activity and supports the ‘VOCC hypothesis’ of PZQ efficacy. Further, in terms of regenerative biology and Ca2+ signaling, these data highlight a novel role for voltage-operated Ca2+ entry in regulating in vivo stem cell differentiation and regenerative patterning. PMID:19554083

Nogi, Taisaku; Zhang, Dan; Chan, John D.; Marchant, Jonathan S.

2009-01-01

38

PRIMEIRA LISTA -FI002 -Teorias de Perturbac~ao 1. Uma particula esta aprisionada em um poco de potencial nulo para  

E-print Network

PRIMEIRA LISTA - FI002 - Teorias de Perturba¸c~ao 1. Uma part´icula est´a aprisionada em um po. Calcule a taxa de autoioniza¸c~ao Auger onde um ´atomo com dois el´etrons inicialmente no n´ivel (2s)2 faz uma transi¸c~ao para o estado de um el´etron no n´ivel (1s) e outro livre. Aproxime o estado livre por

de Aguiar, Marcus A. M.

39

Evaluation of the efficacy of emodepside+praziquantel topical solution against cestode (Dipylidium caninum, Taenia taeniaeformis, and Echinococcus multilocularis) infections in cats.  

PubMed

Emodepside+praziquantel topical solution was developed to provide broad-spectrum anthelmintic activity against gastrointestinal parasites in cats. Eight controlled studies were conducted to evaluate the efficacy of a topical solution of emodepside (3 mg/kg) and praziquantel (12 mg/kg) (Profender, BayerAG, Leverkusen, Germany) against feline infections with three species of cestodes. Studies featured naturally acquired infections of Dipylidium caninum or Taenia taeniaeformis, or experimental infections with Echinococcus multilocularis that were placebo-controlled, randomized and blinded. Cats were euthanatized and necropsied between 2 and 11 days after treatment, depending on the target parasite. The efficacy of emodepside+praziquantel topical solution was 100% against D. caninum and T. taeniaeformis, and 98.5- 100% against E. multilocularis. No significant systemic or local adverse reactions to treatment were noted in cats that received the combination. Topical treatment of cats with emodepside+praziquantel topical solution was safe and highly effective against cestode infections. PMID:16228273

Charles, S D; Altreuther, G; Reinemeyer, C R; Buch, J; Settje, T; Cruthers, L; Kok, D J; Bowman, D D; Kazacos, K R; Jenkins, D J; Schein, E

2005-10-01

40

Representaes Qunticas no Espao de Fases Uma funo de onda abstrata | > um vetor em um espao de Hilbert. Esse vetor pode ser expresso  

E-print Network

Representações Quânticas no Espaço de Fases Uma função de onda abstrata | > é um vetor em um de (q,p) associadas às funções de onda que são, em um certo sentido, o "melhor que se pode fazer.1 - A Transformada de Weyl e a Função de Wigner A transformada de Weyl de um operador ¡ A qualquer é definida como

de Aguiar, Marcus A. M.

41

New praziquantel derivatives containing NO-donor furoxans and related furazans as active agents against Schistosoma mansoni.  

PubMed

A series of NO-donor praziquantel hybrid compounds was obtained by combining praziquantel (PZQ) and furoxan moieties in a single entity. NO-donor properties of the furoxan derivatives were evaluated by detecting nitrite after incubation of the products in 7.4 pH buffered solution in the presence of L-cysteine. Structurally-related furazans, devoid of NO release capacity, were also synthesized for control purposes. All products were studied for their ability to inhibit recombinant Schistosoma mansoni thioredoxin glutathione reductase (TGR). Mobility and death of adult Schistosoma mansoni worms cultured in the presence of the products were evaluated versus PZQ. Analysis of the results showed that some products were endowed with both PZQ and NO-dependent antiparasitic properties. Compounds 6, 7, 18, and 24 emerged as the most interesting balanced hybrids, worthy of additional study on PZQ-resistant parasites. PMID:25016371

Guglielmo, Stefano; Cortese, Daniela; Vottero, Francesca; Rolando, Barbara; Kommer, Valerie P; Williams, David L; Fruttero, Roberta; Gasco, Alberto

2014-09-12

42

Further studies on mefloquine and praziquantel alone or interaction of both drugs against Schistosoma japonicum in vitro  

Microsoft Academic Search

The aim of the present study is to further understand and analyze the interaction of mefloquine with praziquantel against\\u000a adult Schistosoma japonicum in vitro. Mice infected with S. japonicum cercariae for 35–37 days were sacrificed, and adult schistosomes were collected by perfusion. Schistosomes were placed to\\u000a each of 12 wells of a Falcon plate and maintained in RPMI 1640 supplemented by

Shu-hua Xiao; Jian Xue; Hao-bing Zhang

43

Efficacy of mirazid in comparison with praziquantel in Egyptian Schistosoma mansoni-infected school children and households.  

PubMed

This trial investigated the anti-schistosomal activity of mirazid in comparison with that of praziquantel in Schistosoma mansoni-infected Egyptian patients. The sample population was composed of 1,131 individuals (459 school children and 672 household members). Screening for S. mansoni was conducted using the standard Kato Katz technique. Four slides from a single stool sample were examined before treatment, and four slides per sample from stool samples obtained on three consecutive days were examined post-treatment. All positive eligible subjects were randomly assigned into two groups, the first received mirazid at a dose of 300 mg/day for three consecutive days, and the second received praziquantel at a single dose of 40 mg/kg. All treated subjects were examined 4-6 weeks post-treatment. Mirazid showed low cure rates of 9.1% and 8.9% in S. mansoni-infected school children and household members, respectively, compared with cure rates of 62.5% and 79.7%, respectively, in those treated with praziquantel. Therefore, we do not recommend mirazid as an agent to control schistosomiasis. PMID:15741544

Botros, Sanaa; Sayed, Hanan; El-Dusoki, Howaida; Sabry, Hoda; Rabie, Ibrahim; El-Ghannam, Maged; Hassanein, Moataz; El-Wahab, Yehia Abd; Engels, Dirk

2005-02-01

44

An Artemisinin Derivative of Praziquantel as an Orally Active Antischistosomal Agent  

PubMed Central

Background Schistosomiasis is a major health problem in tropical and sub-tropical areas caused by species of trematode belonging to the genus Schistosoma. The treatment and control of this disease has been relying on the use of a single drug praziquantel. However, the drug resistance concern urged the development of new drugs against schistosoma. Here, we report our systematic biological evaluation of DW-3-15, a new lead compound developed based on our conjugation design rationale as an effective anti-schistosomal agent. Methodology/Principal Findings The antischistosomal activity of DW-3-15 was systematically evaluated in S. japonicum infected mouse model for its stage-sensitivity and dose response. The results revealed that DW-3-15 exhibited 60–85% worm reduction rate against different development stage of worm. Scanning electron microscopy (SEM) observation indicated that DW-3-15 may damage to the tegument of male schistosomes. Conclusions/Significance Our results demonstrated that DW-3-15 showed potent anti-schistosomal activities in vivo. The results strongly support our conjugation design strategy of artemisinin analogs and further development of DW-3-15 as a new lead compound as anti-schistosomal agent. PMID:25386745

Chen, Jinglei; Sun, Huan; Qiao, Chunhua; Xia, Chao-ming

2014-01-01

45

Preliminary evidence of transcriptional immunomodulation by praziquantel in bluefin tuna and Atlantic salmon in vitro cultures.  

PubMed

Praziquantel (PZQ), long-used in veterinary and human medicine for the treatment of helminth parasites, is known to enhance humoral and cellular immune responsiveness in mammals but has unknown direct immunomodulatory capabilities in fish. In the present study, we examined the ability of PZQ to induce gene transcriptional changes in immune-competent primary tissue/organ cultures of two highly important yet evolutionarily discrete fish species--Southern bluefin tuna Thunnus maccoyii and Atlantic salmon Salmo salar. These cultures consisted of mixed blood cell population for both species, as well as intestinal explants from bluefin. Although expression profiles varied between species and tissue/organ type, PZQ induced both T-cell receptor (more than twofold) and IL-8 transcriptional expression (more than fourfold). Additionally, increased expression of other inflammatory cytokines including IL-1? was detected in blood cell cultures from both species, and a general pattern of heightened antiviral signaling was observed. Specifically, elevated transcription of Type I (IFN?) and Type II (IFN?) interferon in Atlantic salmon blood cultures along with elevated expression of MHC class I in blood cultures of both species. These findings provide preliminary evidence for direct immunomodulation by PZQ in fish and insight into its potential capacity as an immune stimulant/adjuvant in the rapidly expanding aquaculture industry. PMID:24632044

Polinski, Mark; Bridle, Andrew; Neumann, Lukas; Nowak, Barbara

2014-05-01

46

Propolis enhances the effectiveness of praziquantel in experimental schistosomiasis: biochemical and histopathological study.  

PubMed

Despite the wide current use of praziquantel (PZQ) in treatment of schistosomiasis, low cure rates have been recorded in many studies. The aim of this study was directed to evaluate the curative effect of propolis (Pps) alone or in combination with PZQ on biochemical, immunological, parasitological, and histological changes associated with experimental schistosomiasis in mice. Schistosoma mansoni-infected mice were divided into two experimental sets, each with four subgroups: (i) untreated, (ii) treated with Pps/day p.o for 4 weeks, (iii) treated with PZQ p.o 2?×?500 mg/kg bd wt, and (iv) treated with Pps?+?PZQ as in group ii and iii; all treatments started on the 8th week postinfection, in addition to uninfected group as control for the previous groups. Treatment of infected mice with Pps, although failed to eradicate the worm, significantly reduced the hepatic granuloma number, their lymphocytic infiltration and aggregation, hepatic and splenic myeloperoxidase (MPO) activity and plasma, and liver and thymus nitric oxide (NOx) levels together with normalization of plasma proteins and alleviation of oxidative stress in the examined tissues as evidenced by reduction of malondialdehyde (MDA) and normalization of glutathione (GSH). Promising results were obtained when Pps was given in combination with PZQ, where the anti-schistosomal activity of PZQ was markedly potentiated with complete alleviation and amelioration of the histological and biochemical alteration associated with schistosomiasis. This study highlights the potential usefulness of Pps as an adjunct to PZQ in schistosomiasis. PMID:25266217

Mahmoud, Tamer Y; Rizk, Sherine M; Maghraby, Amany S; Shaheen, Amira A

2014-12-01

47

Inhibition or Knockdown of ABC Transporters Enhances Susceptibility of Adult and Juvenile Schistosomes to Praziquantel  

PubMed Central

Parasitic flatworms of the genus Schistosoma cause schistosomiasis, a neglected tropical disease that affects hundreds of millions. Treatment of schistosomiasis depends almost entirely on the drug praziquantel (PZQ). Though essential to treating and controlling schistosomiasis, a major limitation of PZQ is that it is not active against immature mammalian-stage schistosomes. Furthermore, there are reports of field isolates with heritable reductions in PZQ susceptibility, and researchers have selected for PZQ-resistant schistosomes in the laboratory. P-glycoprotein (Pgp; ABCB1) and other ATP binding cassette (ABC) transporters remove a wide variety of toxins and xenobiotics from cells, and have been implicated in multidrug resistance (MDR). Changes in ABC transporter structure or expression levels are also associated with reduced drug susceptibility in parasitic helminths, including schistosomes. Here, we show that the activity of PZQ against schistosome adults and juveniles ex vivo is potentiated by co-administration of either the highly potent Pgp inhibitor tariquidar or combinations of inhibitors targeting multiple ABC multidrug transporters. Adult worms exposed to sublethal PZQ concentrations remain active, but co-administration of ABC transporter inhibitors results in complete loss of motility and disruption of the tegument. Notably, juvenile schistosomes (3–4 weeks post infection), normally refractory to 2 µM PZQ, become paralyzed when transporter inhibitors are added in combination with the PZQ. Experiments using the fluorescent PZQ derivative (R)-PZQ-BODIPY are consistent with the transporter inhibitors increasing effective intraworm concentrations of PZQ. Adult worms in which expression of ABC transporters has been suppressed by RNA interference show increased responsiveness to PZQ and increased retention of (R)-PZQ-BODIPY consistent with an important role for these proteins in setting levels of PZQ susceptibility. These results indicate that parasite ABC multidrug transporters might serve as important targets for enhancing the action of PZQ. They also suggest a potentially novel and readily-available strategy for overcoming reduced PZQ susceptibility of schistosomes. PMID:25330312

Kasinathan, Ravi S.; Sharma, Lalit Kumar; Cunningham, Charles; Webb, Thomas R.; Greenberg, Robert M.

2014-01-01

48

Albendazole-praziquantel interaction in healthy volunteers: kinetic disposition, metabolism and enantioselectivity  

PubMed Central

AIM This study investigated the kinetic disposition, metabolism and enantioselectivity of albendazole (ABZ) and praziquantel (PZQ) administered alone and in combination to healthy volunteers. METHODS A randomized crossover study was carried out in three phases (n = 9), in which some volunteers started in phase 1 (400 mg ABZ), others in phase 2 (1500 mg PZQ), and the remaining volunteers in phase 3 (400 mg ABZ + 1500 mg PZQ). Serial blood samples were collected from 0–48 h after drug administration. Pharmacokinetic parameters were calculated using a monocompartmental model with lag time and were analyzed using the Wilcoxon test; P? 0.05. RESULTS The administration of PZQ increased the plasma concentrations of (+)-ASOX (albendazole sulphoxide) by 264% (AUC 0.99 vs. 2.59 µg ml?1 h), (?)-ASOX by 358% (0.14 vs. 0.50 µg ml?1 h) and albendazole sulfone (ASON) by 187% (0.17 vs. 0.32 µg ml?1 h). The administration of ABZ did not change the kinetic disposition of (+)-(S)-PZQ (–)-(R)-4-OHPZQ or (+)-(S)-4-OHPZQ, but increased the plasma concentration of (–)-(R)-PZQ by 64.77% (AUC 0.52 vs. 0.86 µg ml?1 h). CONCLUSIONS The pharmacokinetic interaction between ABZ and PZQ in healthy volunteers was demonstrated by the observation of increased plasma concentrations of ASON, both ASOX enantiomers and (–)-(R)-PZQ. Clinically, the combination of ABZ and PZQ may improve the therapeutic efficacy as a consequence of higher concentration of both active drugs. On the other hand, the magnitude of this elevation may represent an increased risk of side effects, requiring, certainly, reduction of the dosage. However, further studies are necessary to evaluate the efficacy and safety of this combination. PMID:21395645

Lima, Renata Monteiro; Ferreira, Maria Augusta Drago; de Jesus Ponte Carvalho, Teresa Maria; Dumet Fernandes, Bruno Jose; Takayanagui, Osvaldo Massaiti; Garcia, Hector Hugo; Coelho, Eduardo Barbosa; Lanchote, Vera Lucia

2011-01-01

49

Solid lipid nanoparticle suspension enhanced the therapeutic efficacy of praziquantel against tapeworm  

PubMed Central

Hydatid disease caused by tapeworm is an increasing public health and socioeconomic concern. In order to enhance the therapeutic efficacy of praziquantel (PZQ) against tapeworm, PZQ-loaded hydrogenated castor oil solid lipid nanoparticle (PZQ-HCO-SLN) suspension was prepared by a hot homogenization and ultrasonication method. The stability of the suspension at 4°C and room temperature was evaluated by the physicochemical characteristics of the nanoparticles and in-vitro release pattern of the suspension. Pharmacokinetics was studied after subcutaneous administration of the suspension in dogs. The therapeutic effect of the novel formulation was evaluated in dogs naturally infected with Echinococcus granulosus. The results showed that the drug recovery of the suspension was 97.59% ± 7.56%. Nanoparticle diameter, polydispersivity index, and zeta potential were 263.00 ± 11.15 nm, 0.34 ± 0.06, and ?11.57 ± 1.12 mV, respectively and showed no significant changes after 4 months of storage at both 4°C and room temperature. The stored suspensions displayed similar in-vitro release patterns as that of the newly prepared one. SLNs increased the bioavailability of PZQ 5.67-fold and extended the mean residence time of the drug from 56.71 to 280.38 hours. Single subcutaneous administration of PZQ-HCO-SLN suspension obtained enhanced therapeutic efficacy against tapeworm in infected dogs. At the dose of 5 mg/kg, the stool-ova reduction and negative conversion rates and tapeworm removal rate of the suspension were 100%, while the native PZQ were 91.55%, 87.5%, and 66.7%. When the dose reduced to 0.5 mg/kg, the native drug showed no effect, but the suspension still got the same therapeutic efficacy as that of the 5 mg/kg native PZQ. These results demonstrate that the PZQ-HCO-SLN suspension is a promising formulation to enhance the therapeutic efficacy of PZQ. PMID:22072873

Xie, Shuyu; Pan, Baoliang; Shi, Baoxin; Zhang, Zhuangzhi; Zhang, Xu; Wang, Ming; Zhou, Wenzhong

2011-01-01

50

Efficacy and Safety of Praziquantel in Preschool-Aged Children in an Area Co-Endemic for Schistosoma mansoni and S. haematobium  

PubMed Central

Background In sub-Saharan Africa the recommended strategy to control schistosomiasis is preventive chemotherapy. Emphasis is placed on school-aged children, but in high endemicity areas, preschool-aged children are also at risk, and hence might need treatment with praziquantel. Since a pediatric formulation (e.g., syrup) is not available outside of Egypt, crushed praziquantel tablets are used, but the efficacy and safety of this treatment regimen is insufficiently studied. Methodology We assessed the efficacy and safety of crushed praziquantel tablets among preschool-aged children (<6 years) in the Azaguié district, south Côte d'Ivoire, where Schistosoma mansoni and S. haematobium coexist. Using a cross-sectional design, children provided two stool and two urine samples before and 3 weeks after treatment. Crushed praziquantel tablets, mixed with water, were administered at a dose of 40 mg/kg. Adverse events were assessed and graded 4 and 24 hours posttreatment by interviewing mothers/guardians. Principal Findings Overall, 160 preschool-aged children had at least one stool and one urine sample examined with duplicate Kato-Katz thick smears and a point-of-care circulating cathodic antigen (POC-CCA) cassette for S. mansoni, and urine filtration for S. haematobium diagnosis before and 3 weeks after praziquantel administration. According to the Kato-Katz and urine filtration results, we found high efficacy against S. mansoni (cure rate (CR), 88.6%; egg reduction rate (ERR), 96.7%) and S. haematobium (CR, 88.9%; ERR, 98.0%). POC-CCA revealed considerably lower efficacy against S. mansoni (CR, 53.8%). Treatment was generally well tolerated, but moderately severe adverse events (i.e., body and face inflammation), were observed in four Schistosoma egg-negative children. Conclusions/Significance Crushed praziquantel administered to preschool-aged children at a dose of 40 mg/kg is efficacious against S. mansoni and S. haematobium in a co-endemic setting of Côte d'Ivoire. Further research is required with highly sensitive diagnostic tools and safety must be investigated in more depth. Trial Registration Controlled-Trials.com ISRCTN53172722 PMID:23236526

Coulibaly, Jean T.; N'Gbesso, Yve K.; Knopp, Stefanie; Keiser, Jennifer; N'Goran, Eliézer K.; Utzinger, Jürg

2012-01-01

51

Sensitivity and Specificity of Multiple Kato-Katz Thick Smears and a Circulating Cathodic Antigen Test for Schistosoma mansoni Diagnosis Pre- and Post-repeated-Praziquantel Treatment  

PubMed Central

Background Two Kato-Katz thick smears (Kato-Katzs) from a single stool are currently recommended for diagnosing Schistosoma mansoni infections to map areas for intervention. This ‘gold standard’ has low sensitivity at low infection intensities. The urine point-of-care circulating cathodic antigen test (POC-CCA) is potentially more sensitive but how accurately they detect S. mansoni after repeated praziquantel treatments, their suitability for measuring drug efficacy and their correlation with egg counts remain to be fully understood. We compared the accuracies of one to six Kato-Katzs and one POC-CCA for the diagnosis of S. mansoni in primary-school children who have received zero to ten praziquantel treatments. We determined the impact each diagnostic approach may have on monitoring and evaluation (M&E) and drug-efficacy findings. Method/Principle Findings In a high S. mansoni endemic area of Uganda, three days of consecutive stool samples were collected from primary school-aged children (six - 12 years) at five time-points in year one: baseline, one-week-post-, four-weeks-post-, six-months-post-, and six-months-one-week-post-praziquantel and three time-points in years two and three: pre-, one-week-post- and four-weeks-post-praziquantel-treatment/retreatment (n?=?1065). Two Kato-Katzs were performed on each stool. In parallel, one urine sample was collected and a single POC-CCA evaluated per child at each time-point in year one (n?=?367). At baseline, diagnosis by two Kato-Katzs (sensitivity?=?98.6%) or one POC-CCA (sensitivity?=?91.7%, specificity?=?75.0%) accurately predicted S. mansoni infections. However, one year later, a minimum of three Kato-Katzs, and two years later, five Kato-Katzs were required for accurate diagnosis (sensitivity >90%) and drug-efficacy evaluation. The POC-CCA was as sensitive as six Kato-Katzs four-weeks-post and six-months-post-treatment, if trace readings were classified as positive. Conclusions/Significance Six Kato-Katzs (two/stool from three stools) and/or one POC-CCA are required for M&E or drug-efficacy studies. Although unable to measure egg reduction rates, one POC-CCA appears to be more sensitive than six Kato-Katzs at four-weeks-post-praziquantel (drug efficacy) and six-months-post-praziquantel (M&E). PMID:25211217

Lamberton, Poppy H. L.; Kabatereine, Narcis B.; Oguttu, David W.; Fenwick, Alan; Webster, Joanne P.

2014-01-01

52

Clinical Efficacy and Tolerability of Praziquantel for Intestinal and Urinary Schistosomiasis—A Meta-analysis of Comparative and Non-comparative Clinical Trials  

PubMed Central

Background Extensive use of praziquantel for treatment and control of schistosomiasis requires a comprehensive understanding of efficacy and safety of various doses for different Schistosoma species. Methodology/Principal Findings A systematic review and meta-analysis of comparative and non-comparative trials of praziquantel at any dose for any Schistosoma species assessed within two months post-treatment. Of 273 studies identified, 55 were eligible (19,499 subjects treated with praziquantel, control treatment or placebo). Most studied were in school-aged children (64%), S. mansoni (58%), and the 40 mg/kg dose (56%); 68% of subjects were in Africa. Efficacy was assessed as cure rate (CR, n?=?17,017) and egg reduction rate (ERR, n?=?13,007); safety as adverse events (AE) incidence. The WHO-recommended dose of praziquantel 40 mg/kg achieved CRs of 94.7% (95%CI 92.2–98.0) for S. japonicum, 77.1% (68.4–85.1) for S. haematobium, 76.7% (95%CI 71.9–81.2) for S. mansoni, and 63.5% (95%CI 48.2–77.0) for mixed S. haematobium/S. mansoni infections. Using a random-effect meta-analysis regression model, a dose-effect for CR was found up to 40 mg/kg for S. mansoni and 30 mg/kg for S. haematobium. The mean ERR was 95% for S. japonicum, 94.1% for S. haematobium, and 86.3% for S. mansoni. No significant relationship between dose and ERR was detected. Tolerability was assessed in 40 studies (12,435 subjects). On average, 56.9% (95%CI 47.4–67.9) of the subjects receiving praziquantel 40 mg/kg experienced an AE. The incidence of AEs ranged from 2.3% for urticaria to 31.1% for abdominal pain. Conclusions/Significance The large number of subjects allows generalizable conclusions despite the inherent limitations of aggregated-data meta-analyses. The choice of praziquantel dose of 40 mg/kg is justified as a reasonable compromise for all species and ages, although in a proportion of sites efficacy may be lower than expected and age effects could not be fully explored. PMID:25412105

Zwang, Julien; Olliaro, Piero L.

2014-01-01

53

Mutagenic and physiological responses in the juveniles of African catfish, Clarias gariepinus (Burchell 1822) following short term exposure to praziquantel.  

PubMed

Praziquantel (PZQ) is an acylated quinoline-pyrazine originally developed for veterinary application but now one of the most used anti-helminthic drugs for treatment of certain trematodes and cestodes in both human and other animals. The present study investigated the mutagenic and physiological responses in the juveniles of African catfish, Clarias gariepinus following short term exposure to praziquantel. Based on the 53.52 mg/l 96 h LC50 of PZQ obtained, two sublethal concentrations of 5.35 and 10.70 mg/l of the drug were selected and fish were exposed to these concentrations and control for 15 days. Micronuclei induction in the peripheral blood of PZQ-exposed fish was highest on day 10 but the fish morphological parameters were not affected. The packed cell volume (PCV) was significantly reduced (p<0.05) from day 5 while red blood cells (RBC) and hemoglobin (Hb) significantly declined (p<0.05) on day 15. Macrocytic anemia was observed on day 1 of study and thereafter microcytic anemia developed on day 5 of study. The white blood cell (WBC) was significantly (p<0.05) elevated from day 10 of exposure while values of mean cellular volume (MCV), mean cellular hemoglobin (MCH) and mean cellular hemoglobin concentration (MCHC) were not significantly different (p>0.05) from the control. Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and glucose levels significantly increased while protein reduced (p<0.05) throughout the exposure period but a mixed trend was observed in the leukocyte differentials. PZQ should be used with caution as sublethal exposure elicited micronucleus induction and alterations of hematological and biochemical parameters in the fish. PMID:24974067

Nwani, Christopher Dididgwu; Nnaji, Macniel Chijioke; Oluah, Stanley Ndubuisi; Echi, Paul Chinedu; Nwamba, Helen Ogochukwu; Ikwuagwu, Ogbonnaya Egbe; Ajima, Malachy Nwigwe Okechukwu

2014-08-01

54

[Praziquantel, levamisole and diflubenzuron in the control of Dolops carvalhoi (Crustacea: Branchiura) and Anacanthorus penilabiatus (Monogenea: Dactylogyridae) in Piaractus mesopotamicus Holmberg, 1887 (Osteichthyes: Characidae)].  

PubMed

This assay evaluated the control efficacy of diflubenzuron, praziquantel and levamisole added to the diet of pacu (Piaractus mesoptamicus) infected with Anacanthorus penilabiatus and Dolops carvalhoi. 19 water tanks of 300 L capacity were utilized with 28 fish in each one. The treatments were made by mixing the active principles in the diet. The experiment was evaluated in four harvests done 1 day before and 3, 7 and 15 days after the treatment. The medicated feeding was applied for 7 days. The results of efficacy suggest that the diflubenzuron alone or associated with levamisole and praziquantel was efficient against the crustacean D. carvalhoi and the efficacy in the 3, 7 and 15 days evaluations ranged from 96.2 to 100%. Against the monogenean the drugs did not present efficacy. The results suggest the use of diflubenzuron for the control of D. carvalhoi in captive fishes in special conditions. PMID:19500462

Schalch, Sergio Henrique Canello; de Moraes, Flávio Ruas; Soares, Vando Edésio

2009-01-01

55

Changes in IgE and Antigen-dependent histamine-release in peripheral blood of Schistosoma mansoni-infected Ugandan fishermen after treatment with praziquantel  

Microsoft Academic Search

BACKGROUND: Parasite-specific IgE levels correlate with human resistance to reinfection with Schistosoma spp. after chemotherapy. Although the role of eosinophils in schistosomiasis has been the focus of a great deal of important research, the involvement of other Fc? receptor-bearing cells, such as mast cells and basophils, has not been investigated in relation to human immunity to schistosomes. Chemotherapy with praziquantel

Mohamed Z Satti; Pierre Cahen; Per S Skov; Sarah Joseph; Frances M Jones; Colin Fitzsimmons; Karl F Hoffmann; Claus Reimert; H Curtis Kariuki; Francis Kazibwe; Joseph K Mwatha; Gachuhi Kimani; Birgitte J Vennervald; John H Ouma; Narcis B Kabatereine; David W Dunne

2004-01-01

56

Effect of Maternal Schistosoma mansoni Infection and Praziquantel Treatment During Pregnancy on Schistosoma mansoni Infection and Immune Responsiveness among Offspring at Age Five Years  

PubMed Central

Introduction Offspring of Schistosoma mansoni-infected women in schistosomiasis-endemic areas may be sensitised in-utero. This may influence their immune responsiveness to schistosome infection and schistosomiasis-associated morbidity. Effects of praziquantel treatment of S. mansoni during pregnancy on risk of S. mansoni infection among offspring, and on their immune responsiveness when they become exposed to S. mansoni, are unknown. Here we examined effects of praziquantel treatment of S. mansoni during pregnancy on prevalence of S. mansoni and immune responsiveness among offspring at age five years. Methods In a trial in Uganda (ISRCTN32849447, http://www.controlled-trials.com/ISRCTN32849447/elliott), offspring of women treated with praziquantel or placebo during pregnancy were examined for S. mansoni infection and for cytokine and antibody responses to SWA and SEA, as well as for T cell expression of FoxP3, at age five years. Results Of the 1343 children examined, 32 (2.4%) had S. mansoni infection at age five years based on a single stool sample. Infection prevalence did not differ between children of treated or untreated mothers. Cytokine (IFN?, IL-5, IL-10 and IL-13) and antibody (IgG1, Ig4 and IgE) responses to SWA and SEA, and FoxP3 expression, were higher among infected than uninfected children. Praziquantel treatment of S. mansoni during pregnancy had no effect on immune responses, with the exception of IL-10 responses to SWA, which was higher in offspring of women that received praziquantel during pregnancy than those who did not. Conclusion We found no evidence that maternal S. mansoni infection and its treatment during pregnancy influence prevalence and intensity of S. mansoni infection or effector immune response to S. mansoni infection among offspring at age five years, but the observed effects on IL-10 responses to SWA suggest that maternal S. mansoni and its treatment during pregnancy may affect immunoregulatory responsiveness in childhood schistosomiasis. This might have implications for pathogenesis of the disease. PMID:24147175

Tweyongyere, Robert; Naniima, Peter; Mawa, Patrice A.; Jones, Frances M.; Webb, Emily L.; Cose, Stephen; Dunne, David W.; Elliott, Alison M.

2013-01-01

57

Praziquantel form, dietary application method and dietary inclusion level affect palatability and efficacy against monogenean parasites in yellowtail kingfish.  

PubMed

The bitterness of racemic praziquantel (PZQ) currently constrains its use as an in-feed treatment against monogenean flukes in finfish aquaculture. In an effort to increase the palatability of diets containing racemic PZQ for yellowtail kingfish, the palatability and efficacy of 2 forms of racemic PZQ (powder or powder within microcapsules) against natural infestations of skin and gill flukes were compared using 2 different dietary application methods (incorporated within the pellet mash prior to extrusion or surface-coated after extrusion) at active dietary inclusion levels of 8, 16 and 25 g kg-1 in large (3.5-4 kg) yellowtail kingfish. There was no clear benefit of incorporating PZQ into diets prior to extrusion. PZQ microcapsules improved the palatability of PZQ-containing diets but did not completely mask the bitter flavour. At the lowest active dietary inclusion level of 8 g kg-1, ingestion of the diet containing PZQ microcapsules was equal to the control and significantly better than that containing PZQ powder. At an inclusion level of 16 g kg-1, ingestion of the PZQ microcapsule diet was significantly better than that containing the same inclusion of PZQ powder but significantly lower than the control. Consumption of the diet containing 25 g kg-1 of PZQ microcapsules was poor. All fish consuming medicated feeds had a significant reduction in flukes relative to control fish; however, efficacy data and blood serum analysis suggested that diets containing PZQ microcapsules had lower bioavailability than those containing PZQ powder. PMID:24991743

Partridge, G J; Michael, R J; Thuillier, L

2014-05-13

58

Comparative study of the hepatotoxic, genotoxic and carcinogenic effects of praziquantel distocide & the natural myrrh extract Mirazid on adult male albino rats.  

PubMed

Praziquantel (PZQ) is widely and effectively used in the control of bilharziasis which constitutes a major endemic health problem in Egypt. However, recent studies recommended that the drug must be re-evaluated because of its potential carcinogenicity and genotoxicity. Mirazid is a new natural anti-schistosomal drug formed of myrrh extract and considered to be a safe drug. This work was conducted to evaluate and compare hepatotoxic, genotoxic and carcinogenic effects of PZQ and Mirazid on adult male albino rats by assessment of serum levels of ALT, AST and bilirubin, histopathological study of the liver and cytogenetic study of bone marrow cells. 100 adult male albino rats were equally divided into 4 groups: (I): negative control, (II): control rats received distilled water, (III): received weekly single oral dose of PZQ (1500 mg/kg) for 6 weeks, (IV): received daily oral dose of Mirazid (500 mg/kg) for 6 weeks. At the end of the study 10 rats of each group were investigated by assessment of the levels of AST, ALT, & Bilirubin. After scarification, liver sections were examined by light microscopy. Another 10 rats of each group were submitted to cytogenetic examination. It was found that praziquantel induced a significant increase in the mean values of AST, ALT and bilirubin with areas of hyaline degeneration, fatty changes, dysplasia and necrosis in the liver sections. It also induced a significant increase in the incidence of chromosomal aberrations as polyploidy, fragment, deletion and ring chromosome as compared with control group. Mirazid induced a non significant increase in the mean values of AST, ALT and bilirubin, with a normal hepatic tissue, and a non significant increase in the incidence of chromosomal aberrations, as compared with the control group. On comparing both drugs, praziquantel induced a significant hepatotoxic, genotoxic and carcinogenic effects. It was concluded that, Praziquantel is considered to be a hepatotoxic, genotoxic and carcinogenic drug. On the other hand, Mirazid seemed to be a safe and promising antiparasitic drug, free from hepatotoxic, genotoxic and carcinogenic effects. PMID:15881015

Omar, Ahmed; Elmesallamy, Ghada El-Said; Eassa, Shereen

2005-04-01

59

Chemometric quality inspection control of pyrantel pamoate, febantel and praziquantel in veterinary tablets by mid infrared spectroscopy  

NASA Astrophysics Data System (ADS)

This paper describes the development and validation of a new multivariate calibration method based on diffuse reflectance mid infrared spectroscopy for direct and simultaneous determination of three veterinary pharmaceutical drugs, pyrantel pamoate, praziquantel and febantel, in commercial tablets. The best synergy interval partial least squares (siPLS) model was obtained by selecting three spectral regions, 3715-3150, 2865-2583, and 2298-1733 cm-1, preprocessed by first derivative and Savitzky-Golay smoothing followed by mean centering. This model was built with five latent variables and provided root mean square errors of prediction (RMSEP) equal or lower than 0.69 mg per 100 mg of powder for the three analytes. The method was validated according the appropriate regulations through the estimate of figures of merit, such as trueness, precision, linearity, analytical sensitivity, bias and residual prediction deviation (RPD). Then, it was applied to three different veterinary pharmaceutical formulations found in the Brazilian market, in a situation of multi-product calibration, since the excipient composition of these commercial products, which was not known a priori, was modeled by an experimental design that scanned the likely content range of the possible constituents. The results were verified with high performance liquid chromatography with diode array detection (HPLC-DAD) and high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) and were in agreement with the predicted values at 95% confidence level. The developed method presented the advantages of being simple, rapid, solvent free, and about ten times faster than the HPLC ones.

Piantavini, Mário S.; Pontes, Flávia L. D.; Uber, Caroline P.; Stremel, Dile P.; Sena, Marcelo M.; Pontarolo, Roberto

60

Efficacy in cats of a novel topical combination of fipronil, (S)-methoprene, eprinomectin, praziquantel, against induced infestations of Echinococcus multilocularis.  

PubMed

Although foxes are the main reservoir of Echinococcus multilocularis, it is recognized that dogs and cats also may become infected. In cats the infection and egg production rates are usually low. Nevertheless, cats are a potential source of transmission of E. multilocularis. Due to the high human medical significance of E. multilocularis infection, it is important in endemic areas that owned cats are dewormed regularly. This paper presents the efficacy results of a new topical formulation, Broadline(®) (Merial) tested against E. multilocularis infection in cats. Two blinded laboratory studies were conducted to evaluate this novel topical combination of fipronil, (S)-methoprene, eprinomectin, and praziquantel against E. multilocularis. In each study, purpose-bred cats were assigned randomly to two treatment groups of 10 cats each: one untreated control group and one group treated at the minimum therapeutic dose of 0.12 mL/kg bodyweight to deliver 10mg fipronil, 12 mg (S)-methoprene, 0.5mg eprinomectin and 10mg praziquantel/kg bodyweight. The cats were inoculated orally with E. multilocularis protoscolices, 22 or 23 days before treatment. Based on necropsy and intestinal worm count, 8 or 11 days after treatment, the two studies confirmed 100% efficacy of Broadline(®) against adult E. multilocularis. PMID:24703072

Tielemans, Eric; Manavella, Coralie; Visser, Martin; Theodore Chester, S; Rosentel, Joseph

2014-04-28

61

Efficacy of praziquantel and reinfection patterns in single and mixed infection foci for intestinal and urogenital schistosomiasis in Cameroon.  

PubMed

The regular administration of the anthelminthic drug praziquantel (PZQ) to school-aged children (and other high-risk groups) is the cornerstone of schistosomiasis control. Whilst the performance of PZQ against single schistosome species infections is well-known, performance against mixed species infections is less so, as are patterns of re-infection following treatment. To address this, a study using a double treatment with PZQ, administered at 40 mg/kg spaced by 3 weeks, took place in two mixed intestinal-urogenital schistosomiasis foci in northern Cameroon (Bessoum and Ouro-Doukoudje) and in one single intestinal schistosomiasis infection focus (Makenene). A total of just under 1000 children were examined and the Schistosoma-infected children were re-examined at several parasitological follow-ups over a 1-year period posttreatment. Overall cure rates against Schistosoma spp. in the three settings were good, 83.3% (95% confidence interval (CI)=77.9-87.7%) in Bessoum, 89.0% (95% CI=79.1-94.6%) in Ouro Doukoudje, and 95.3% (95% CI=89.5-98.0%) in Makenene. Interestingly, no case of mixed schistosome infection was found after treatment. Cure rates for S. mansoni varied from 99.5% to 100%, while that for S. haematobium were considerably lower, varying from 82.7% to 88.0%. Across transmission settings, patterns of re-infection for each schistosome species were different such that generalizations across foci were difficult. For example, at the 6-month follow-up, re-infection rates were higher for S. haematobium than for S. mansoni with re-infection rates for S. haematobium varying from 9.5% to 66.7%, while for S. mansoni, lower rates were observed, ranging between nil and 24.5%. At the 12-month follow-up, re-infection rates varied from 9.1% to 66.7% for S. haematobium and from nil to 27.6% for S. mansoni. Alongside these parasitological studies, concurrent malacological surveys took place to monitor the presence of intermediate host snails of schistosomiasis. In the two northern settings, three species of Bulinus (intermediate host snail of S. haematobium) were collected; i.e. Bulinus truncatus, B. globosus and B. senegalensis, however, Biomphalaria pfeifferi (intermediate host snail of S. mansoni) was much rarer despite repeated and intensive searching and was suggestive of limited local transmission potential of S. mansoni during this time. While this study highlights that performance of PZQ was satisfactory in this region, with somewhat greater impact upon intestinal than urogenital schistosomiasis, the dynamics of local transmission are shown, however, to be complex. PMID:23791803

Tchuem Tchuenté, Louis-Albert; Momo, Sabine C; Stothard, J Russell; Rollinson, David

2013-11-01

62

Efficacy of a novel topical combination of fipronil, (S)-methoprene, eprinomectin and praziquantel against feline urinary bladder worm (Capillaria plica) infection.  

PubMed

Infection with urinary capillarid bladder worms has been observed in cats worldwide. Although considered as generally causing no or little harm, infection with urinary capillarids may be associated with clinical disease which requires an appropriate treatment including the use of anthelmintics. Therefore, the efficacy of a novel topical combination formulation of fipronil 8.3% (w/v), (S)-methoprene 10% (w/v), eprinomectin 0.4% (w/v), and praziquantel 8.3% (w/v) (BROADLINE(®), Merial) was evaluated against urinary capillarids in naturally infected cats. Sixteen European Short Hair cats (5 male, 11 female) with capillarid eggs in their urine pre-treatment were included in the study. At the time of treatment, the cats were approximately ten months to eight years old and weighed 1.6-3.6 kg. Cats were ranked based on decreasing bodyweight and then randomly allocated within replicates of two animals to one of the treatment groups. Each cat in the treated group received one topical application of the combination product at the minimum therapeutic dose of 0.12 mL/kg body weight delivering 10mg fipronil+12 mg (S)-methoprene+0.5mg eprinomectin+10mg praziquantel per kilogram of body weight while the cats allocated to the control group remained untreated. For parasite recovery, identification and count, cats were euthanized humanely 14 days after treatment. All untreated cats harboured Capillaria plica in their urinary bladders (range 4-12), while no capillarids were recovered from the eight treated cats. Thus, the efficacy of the novel topical combination against C. plica was 100%. All cats accepted the treatment well based on post-treatment observations and daily observations thereafter. No adverse events or other health problems were observed during the study. PMID:24703076

Knaus, Martin; Shukullari, Enstela; Rosentel, Joseph; Rehbein, Steffen

2014-04-28

63

Efficacy and side effects of praziquantel in the treatment of Schistosomiasis mansoni in schoolchildren in Shesha Kekele Elementary School, Wondo Genet, Southern Ethiopia  

PubMed Central

Objective To evaluate the efficacy and side effects of praziquantel (PZQ) in the treatment of schistosomiasis in Ethiopia. Methods In a cross-sectional study, stool specimens were collected from randomly selected 299 school children in Shesha Kekele Elementary School, Wondo Genet, Southern Ethiopia, in April 2010. Stool specimens were examined using a single Kato-Katz thick smear for Schistosoma mansoni (S. mansoni) ova. Children who were found positive for S. mansoni were treated with a single oral dose of PZQ at 40 mg/kg bw and interviewed for treatment-related symptoms 24 hours after drug administration. Four weeks post-treatment, stool specimens were collected from the same children and examined following the same procedure as in the pre-treatment. Drug efficacy was determined based on cure and egg reduction rates. Results Pre-treatment prevalence of S. mansoni infection was 74.9% with geometric mean egg count of 268. The evaluated generic PZQ produced an overall cure rate of 73.6% (P<0.000 1, OR: 8.33, CI: 5.3–13.1) and egg reduction rate of 68.2% (P=0.03, F=0.64). The cure rate showed significant association with age (?2=11, P=0.004), the highest rate being observed in the 15–22 age group. 83% of S. mansoni infected children showed various treatment-related symptoms, the most frequent being headache, nausea, and abdominal pain. These symptoms were associated with age (P<0.001) and pre-treatment intensity of infection (P<0.05). Conclusions The present observations revealed relatively lower cure and egg reduction rates of the PZQ evaluated as compared to previous reports for other PZQ brands in Ethiopia. Hence, in depth studies are recommended to clarify whether the present relatively lower cure rate is the actual cure rate of the praziquantel evaluated, treatment failure, or reduced susceptibility of the parasite. Treatment-related side effects observed were transient and tolerable. PMID:23569905

Erko, Berhanu; Degarege, Abraham; Tadesse, Konjit; Mathiwos, Asnake; Legesse, Mengistu

2012-01-01

64

Carcinoma espinocelular cutâneo em cães.  

E-print Network

??Dissertação de Mestrado Integrado em Medicina Veterinária O Carcinoma Espinocelular (CEC) é uma neoplasia com origem nos queratinócitos e representa aproximadamente 5% das neoplasias cutâneas… (more)

Moura, Inês da Costa

2012-01-01

65

Treatment of schistosomiasis in African infants and preschool-aged children: downward extension and biometric optimization of the current praziquantel dose pole  

PubMed Central

Summary To facilitate administration of praziquantel (PZQ) to African infants and preschool-aged children using a dose pole, the performance of two downwardly extended versions (the first created in 2010 using biometric data from Uganda alone and the second version created here using data from 36 countries) was assessed against height/weight data from a total of 166 210 preschool-aged children (?6 year olds) from 36 African countries. New and optimized thresholds for PZQ tablet administration at one tablet (600 mg), ¾ and ½ tablet divisions are suggested here. Both dose poles investigated estimated an acceptable PZQ dosage (30–60 mg/Kg) for more than 95% of children. Extension and optimization of the current PZQ dose pole, followed by theoretical validation using biometric data from preschool-aged children (0–6 years of age, 60–110 cm in height) from 36 African countries will help future mass drug administration campaigns incorporate younger children. This newly optimized dose pole with single 600 mg (height: 99–110 cm), ¾ (height: 83–99 cm) and ½ (height: 66–83 cm) tablet divisions, also reduces drug waste and facilitates inclusion of preschool-aged children. Our findings also have bearings on the use of other dose poles for treatment of young children. PMID:22876272

Sousa-Figueiredo, Jose C.; Betson, Martha; Stothard, J. Russell

2012-01-01

66

Efficacy of bath and orally administered praziquantel and fenbendazole against Lepidotrema bidyana Murray, a monogenean parasite of silver perch, Bidyanus bidyanus (Mitchell).  

PubMed

We investigated the efficacy of praziquantel (PZQ) and fenbendazole (FBZ), each administered by bath and orally, against the monogenean Lepidotrema bidyana Murray, a gill parasite of the freshwater fish silver perch, Bidyanus bidyanus (Mitchell). PZQ and FBZ were each administered by bath at 10 mg L?¹ for 48 h and on surface-coated feed pellets at 75 mg kg?¹ per body weight (BW) per day for 6 days. Bath treatments of PZQ and FBZ had an efficacy of 99% and 91%, respectively, against adult L. bidyana. Oral treatments of PZQ and FBZ had an efficacy of 79% and 95%, respectively, against adult L. bidyana. Fish rejected feed pellets surface-coated with PZQ, suggesting that palatability of surface-coated PZQ-medicated feed is poor, which undermined efficacy. In all trials, some juvenile parasites were present on fish after treatment during efficacy assessment, indicating that efficacy may be lower against juvenile parasites or that recruitment occurred post-treatment, demonstrating that repeat treatments are necessary to effectively control L. bidyana in aquaculture. PMID:23488766

Forwood, J M; Harris, J O; Deveney, M R

2013-11-01

67

Closing the praziquantel treatment gap: new steps in epidemiological monitoring and control of schistosomiasis in African infants and preschool-aged children  

PubMed Central

SUMMARY Where very young children come into contact with water containing schistosome cercariae, infections occur and schistosomiasis can be found. In high transmission environments, where mothers daily bathe their children with environmentally drawn water, many infants and preschool-aged children have schistosomiasis. This ‘new’ burden, inclusive of co-infections with Schistosoma haematobium and Schistosoma mansoni, is being formally explored as infected children are not presently targeted to receive praziquantel (PZQ) within current preventive chemotherapy campaigns. Thus an important PZQ treatment gap exists whereby infected children might wait up to 4–5 years before receiving first treatment in school. International treatment guidelines, set within national treatment platforms, are presently being modified to provide earlier access to medication(s). Although detailed pharmacokinetic studies are needed, to facilitate pragmatic dosing in the field, an extended ‘dose pole’ has been devised and epidemiological monitoring has shown that administration of PZQ (40 mg/kg), in either crushed tablet or liquid suspension, is both safe and effective in this younger age-class; drug efficacy, however, against S. mansoni appears to diminish after repeated rounds of treatment. Thus use of PZQ should be combined with appropriate health education/water hygiene improvements for both child and mother to bring forth a more enduring solution. PMID:21861945

STOTHARD, J. RUSSELL; SOUSA-FIGUEIREDO, JOSE C.; BETSON, MARTHA; GREEN, HELEN K.; SETO, EDMUND Y. W.; GARBA, AMADOU; SACKO, MOUSSA; MUTAPI, FRANCISCA; VAZ NERY, SUSANA; AMIN, MUTAMAD A.; MUTUMBA-NAKALEMBE, MARGARET; NAVARATNAM, ANNALAN; FENWICK, ALAN; KABATEREINE, NARCIS B.; GABRIELLI, ALBIS F.; MONTRESOR, ANTONIO

2011-01-01

68

A Latent Markov Modelling Approach to the Evaluation of Circulating Cathodic Antigen Strips for Schistosomiasis Diagnosis Pre- and Post-Praziquantel Treatment in Uganda  

PubMed Central

Regular treatment with praziquantel (PZQ) is the strategy for human schistosomiasis control aiming to prevent morbidity in later life. With the recent resolution on schistosomiasis elimination by the 65th World Health Assembly, appropriate diagnostic tools to inform interventions are keys to their success. We present a discrete Markov chains modelling framework that deals with the longitudinal study design and the measurement error in the diagnostic methods under study. A longitudinal detailed dataset from Uganda, in which one or two doses of PZQ treatment were provided, was analyzed through Latent Markov Models (LMMs). The aim was to evaluate the diagnostic accuracy of Circulating Cathodic Antigen (CCA) and of double Kato-Katz (KK) faecal slides over three consecutive days for Schistosoma mansoni infection simultaneously by age group at baseline and at two follow-up times post treatment. Diagnostic test sensitivities and specificities and the true underlying infection prevalence over time as well as the probabilities of transitions between infected and uninfected states are provided. The estimated transition probability matrices provide parsimonious yet important insights into the re-infection and cure rates in the two age groups. We show that the CCA diagnostic performance remained constant after PZQ treatment and that this test was overall more sensitive but less specific than single-day double KK for the diagnosis of S. mansoni infection. The probability of clearing infection from baseline to 9 weeks was higher among those who received two PZQ doses compared to one PZQ dose for both age groups, with much higher re-infection rates among children compared to adolescents and adults. We recommend LMMs as a useful methodology for monitoring and evaluation and treatment decision research as well as CCA for mapping surveys of S. mansoni infection, although additional diagnostic tools should be incorporated in schistosomiasis elimination programs. PMID:24367250

Koukounari, Artemis; Donnelly, Christl A.; Moustaki, Irini; Tukahebwa, Edridah M.; Kabatereine, Narcis B.; Wilson, Shona; Webster, Joanne P.; Deelder, Andre M.; Vennervald, Birgitte J.; van Dam, Govert J.

2013-01-01

69

Preventive efficacy of a topical combination of fipronil - (S)-methoprene - eprinomectin - praziquantel against ear mite (Otodectes cynotis) infestation of cats through a natural infestation model  

PubMed Central

A study based on naturally infested cats was designed to evaluate the effectiveness of a single treatment with a topical formulation containing fipronil, (S)-methoprene, eprinomectin and praziquantel, for the prevention of Otodectes cynotis infestation in cats. Six treated cats and six untreated cats were housed with three chronically Otodectes cynotis-infested cats, respectively. The cats of each group were kept together in a 20-m2 room for 1 month. Both clinical examination and ear mite counts were conducted on Day 28. All donor cats were confirmed to be chronically infested with Otodectes cynotis on Day ?1 and Day 28. From untreated control cats, 129 live mites were recovered on Day 28 and all cats were found to be infested. In the treated group, three cats were found to be infested, with a total of five live mites recovered, the difference between the two groups being significant (p = 0.003). One treatment corresponded to 96% preventive efficacy at Day 28 based on ear mite counts. With regard to cerumen, the clinical score increased significantly for untreated cats between Day ?1 and Day 28 (p = 0.00026) and not for treated cats (p = 0.30). The difference in cerumen abundance was significant between untreated and treated cats on Day 28 (p = 0.0035). Concerning the pruritic reflex in at least one ear, all cats were negative at inclusion. All six untreated cats became positive and showed a reflex on Day 28, whereas no treated cat showed ear pruritus (p = 0.00026). PMID:25148648

Beugnet, Frederic; Bouhsira, Emilie; Halos, Lenaig; Franc, Michel

2014-01-01

70

Preventive efficacy of a topical combination of fipronil--(S)-methoprene--eprinomectin--praziquantel against ear mite (Otodectes cynotis) infestation of cats through a natural infestation model.  

PubMed

A study based on naturally infested cats was designed to evaluate the effectiveness of a single treatment with a topical formulation containing fipronil, (S)-methoprene, eprinomectin and praziquantel, for the prevention of Otodectes cynotis infestation in cats. Six treated cats and six untreated cats were housed with three chronically Otodectes cynotis-infested cats, respectively. The cats of each group were kept together in a 20-m(2) room for 1 month. Both clinical examination and ear mite counts were conducted on Day 28. All donor cats were confirmed to be chronically infested with Otodectes cynotis on Day -1 and Day 28. From untreated control cats, 129 live mites were recovered on Day 28 and all cats were found to be infested. In the treated group, three cats were found to be infested, with a total of five live mites recovered, the difference between the two groups being significant (p = 0.003). One treatment corresponded to 96% preventive efficacy at Day 28 based on ear mite counts. With regard to cerumen, the clinical score increased significantly for untreated cats between Day -1 and Day 28 (p = 0.00026) and not for treated cats (p = 0.30). The difference in cerumen abundance was significant between untreated and treated cats on Day 28 (p = 0.0035). Concerning the pruritic reflex in at least one ear, all cats were negative at inclusion. All six untreated cats became positive and showed a reflex on Day 28, whereas no treated cat showed ear pruritus (p = 0.00026). PMID:25148648

Beugnet, Frédéric; Bouhsira, Emilie; Halos, Lénaïg; Franc, Michel

2014-01-01

71

Pharmacokinetics and metabolism of eprinomectin in cats when administered in a novel topical combination of fipronil, (S)-methoprene, eprinomectin and praziquantel.  

PubMed

Four studies were conducted to determine the pharmacokinetic characteristics and in vitro metabolism of eprinomectin, a semi-synthetic avermectin, in cats. Pharmacokinetic parameters including bioavailability of eprinomectin were determined in a parallel study design comprised of one group of eight cats which were treated once topically at 0.12 mL/kg bodyweight with BROADLINE(®), a novel combination product (fipronil 8.3% (w/v), (S)-methoprene 10% (w/v), eprinomectin 0.4% (w/v) and praziquantel 8.3% (w/v)), delivering a dose of 0.5mg eprinomectin per kg body weight, and a group of six cats which received 0.4% (w/v) eprinomectin at 0.4 mg/kg bodyweight once by intravenous injection. For cats treated by topical application, the average eprinomectin (B1a component) maximum plasma concentration (Cmax) was 20 ng/mL. The maximum concentrations were reached 24h after dosing in the majority of the animals (six of eight cats). The average terminal half-life was 114 h due to slow absorption ('flip-flop' kinetics). Following intravenous administration the average Cmax was 503 ng/mL at 5 min post-dose, and the mean elimination half-life was 23 h. Eprinomectin was widely distributed with a mean volume of distribution of 2,390 mL/kg, and the clearance rate was 81 mL/h/kg. Mean areas under the plasma concentration versus time curves extrapolated to infinity were 2,100 ngh/mL and 5,160 ngh/mL for the topical and intravenous doses, respectively. Topical eprinomectin was absorbed with an average absolute bioavailability of 31%. In a second parallel design study, the dose proportionality of eprinomectin after single topical administration of BROADLINE(®) was studied. Four groups of eight cats each were treated once topically with 0.5, 1, 2 or 5 times the minimum recommended dose of the combination, 0.12 mL/kg bodyweight. Based on comparison of areas under the plasma concentration versus time curves from the time of dosing to the last time point at which eprinomectin B1a was quantified, and Cmax, dose proportionality was established. In addition, the metabolic pathway of eprinomectin using cat liver microsomes, and plasma protein binding using cat, rat, and dog plasma were studied in vitro. Results of the analyses of eprinomectin B1a described here showed that it is metabolically stable and highly protein bound (>99%), and thus likely to be, as with other species, excreted mainly as unchanged parent drug in the feces of cats. PMID:24703069

Kvaternick, Valerie; Kellermann, Michael; Knaus, Martin; Rehbein, Steffen; Rosentel, Joseph

2014-04-28

72

Cytokine Responses to the Anti-schistosome Vaccine Candidate Antigen Glutathione-S-transferase Vary with Host Age and Are Boosted by Praziquantel Treatment  

PubMed Central

Background Improved helminth control is required to alleviate the global burden of schistosomiasis and schistosome-associated pathologies. Current control efforts rely on the anti-helminthic drug praziquantel (PZQ), which enhances immune responses to crude schistosome antigens but does not prevent re-infection. An anti-schistosome vaccine based on Schistosoma haematobium glutathione-S-transferase (GST) is currently in Phase III clinical trials, but little is known about the immune responses directed against this antigen in humans naturally exposed to schistosomes or how these responses change following PZQ treatment. Methodology Blood samples from inhabitants of a Schistosoma haematobium-endemic area were incubated for 48 hours with or without GST before (n?=?195) and six weeks after PZQ treatment (n?=?107). Concentrations of cytokines associated with innate inflammatory (TNF?, IL-6, IL-8), type 1 (Th1; IFN?, IL-2, IL-12p70), type 2 (IL-4, IL-5, IL-13), type 17 (IL-17A, IL-21, IL-23p19) and regulatory (IL-10) responses were quantified in culture supernatants via enzyme-linked immunosorbent assay (ELISA). Factor analysis and multidimensional scaling were used to analyse multiple cytokines simultaneously. Principal Findings A combination of GST-specific type 2 (IL-5 and IL-13) and regulatory (IL-10) cytokines was significantly lower in 10–12 year olds, the age group at which S. haematobium infection intensity and prevalence peak, than in 4–9 or 13+ year olds. Following PZQ treatment there was an increase in the number of participants producing detectable levels of GST-specific cytokines (TNF?, IL-6, IL-8, IFN?, IL-12p70, IL-13 and IL-23p19) and also a shift in the GST-specific cytokine response towards a more pro-inflammatory phenotype than that observed before treatment. Participant age and pre-treatment infection status significantly influenced post-treatment cytokine profiles. Conclusions/Significance In areas where schistosomiasis is endemic host age, schistosome infection status and PZQ treatment affect the cellular cytokine response to GST. Thus the efficacy of a GST-based vaccine may also be shaped by the demographic and epidemiological characteristics of targeted populations. PMID:24810615

Bourke, Claire D.; Nausch, Norman; Rujeni, Nadine; Appleby, Laura J.; Trottein, Francois; Midzi, Nicholas; Mduluza, Takafira; Mutapi, Francisca

2014-01-01

73

A Multicentre Randomized Controlled Trial of the Efficacy and Safety of Single-Dose Praziquantel at 40 mg/kg vs. 60 mg/kg for Treating Intestinal Schistosomiasis in the Philippines, Mauritania, Tanzania and Brazil  

PubMed Central

Background Praziquantel at 40 mg/kg in a single dose is the WHO recommended treatment for all forms of schistosomiasis, but 60 mg/kg is also deployed nationally. Methodology/Principal Findings Four trial sites in the Philippines, Mauritania, Tanzania and Brazil enrolled 856 patients using a common protocol, who were randomised to receive praziquantel 40 mg/kg (n?=?428) or 60 mg/kg (n?=?428). While the sites differed for transmission and infection intensities (highest in Tanzania and lowest in Mauritania), no bias or heterogeneity across sites was detected for the main efficacy outcomes. The primary efficacy analysis was the comparison of cure rates on Day 21 in the intent-to-treat population for the pooled data using a logistic model to calculate Odd Ratios allowing for baseline characteristics and study site. Both doses were highly effective: the Day 21 cure rates were 91.7% (86.6%–98% at individual sites) with 40 mg/kg and 92.8% (88%–97%) with 60 mg/kg. Secondary parameters were eggs reduction rates (ERR), change in intensity of infection and reinfection rates at 6 and 12 months. On Day 21 the pooled estimate of the ERR was 91% in both arms. The Hazard Ratio for reinfections was only significant in Brazil, and in favour of 60 mg/kg on the pooled estimate (40 mg/kg: 34.3%, 60 mg/kg: 23.9%, HR?=?0.78, 95%CI?=?[0.63;0.96]). Analysis of safety could not distinguish between disease- and drug-related events. 666 patients (78%) reported 1327 adverse events (AE) 4 h post-dosing. The risk of having at least one AE was higher in the 60 than in the 40 mg/kg group (83% vs. 73%, p<0.001). At 24 h post-dosing, 456 patients (54%) had 918 AEs with no difference between arms. The most frequent AE was abdominal pain at both 4 h and 24 h (40% and 24%). Conclusion A higher dose of 60 mg/kg of praziquantel offers no significant efficacy advantage over standard 40 mg/kg for treating intestinal schistosomiasis caused by either S. mansoni or S. japonicum. The results of this study support WHO recommendation and should be used to inform policy decisions in the countries. Trial Registration Controlled-Trials.com ISRCTN29273316 ClinicalTrials.gov NCT00403611 PMID:21695161

Olliaro, Piero L.; Vaillant, Michel T.; Belizario, Vincente J.; Ouldabdallahi, Mohamed; Pieri, Otavio S.; Amarillo, Maria L.; Kaatano, Godfrey M.; Diaw, Mamadou; Domingues, AnaLucia C.; Favre, Tereza C.; Lapujade, Olivier; Alves, Fabiana; Chitsulo, Lester

2011-01-01

74

Efficacy against nematode and cestode infections and safety of a novel topical fipronil, (S)-methoprene, eprinomectin and praziquantel combination product in domestic cats under field conditions in Europe.  

PubMed

A novel topical combination product (BROADLINE(®), Merial) composed of fipronil, (S)-methoprene, eprinomectin and praziquantel was evaluated for safety and efficacy against nematode and cestode infections in domestic cats. The study comprised a multi-centre, positive control, blinded, field study, using a randomized block design based on order of presentation for allocation. In total 196 client-owned cats, confirmed as positive for naturally acquired infections of nematodes and/or cestodes by pre-treatment faecal examination, were studied in seven countries in Europe. Pre-treatment faecal examination revealed the presence of Toxocara, hookworm, Capillaria and/or spirurid nematode infections in 129, 73, 33 or 1 cat(s), respectively; infections with taeniid and Dipylidium cestodes were demonstrated in 39 and 17 cats, respectively. Cats were allocated randomly to one of two treatments in a ratio of 2, topical fipronil (8.3%, w/v), (S)-methoprene (10%, w/v), eprinomectin (0.4%, w/v) and praziquantel (8.3%, w/v) (BROADLINE(®), Merial; 130 cats); and 1, topical PROFENDER(®) Spot-On (Bayer; 66 cats) and treated once on Day 0. For evaluation of efficacy, two faecal samples were collected, one prior to treatment (Day -4 ± 4 days) and one at the end of the study (Day 14 ± 5 days). These were examined for fecal forms of nematode and cestode parasites. For evaluation of safety, cats were examined by a veterinarian before treatment and at the end of the study, and cat owners recorded the health status of their cats daily until the end of the study. For cats treated with Broadline(®), the efficacy was >99.9%, 100%, and 99.6% for Toxocara, hookworms, and Capillaria, respectively; and the efficacy was >99.9%, >99.9%, and 98.5%, respectively, for the cats treated with Profender(®) (p<0.001 for all nematodes and both treatments). Efficacy was 100% for both cestodes for both treatments (p<0.001). No treatment related adverse experiences were observed throughout the study. For both treatments, every cat that completed the study was given a safety score of 'excellent' for both local and systemic evaluations. The topical combination product of fipronil, (S)-methoprene, eprinomectin and praziquantel was shown to have an excellent safety profile and demonstrated high levels of efficacy when administered once as topical solution to cats infected with nematodes and cestodes under field conditions. PMID:24703070

Rehbein, Steffen; Capári, Balazs; Duscher, Georg; Keidane, Dace; Kirkova, Zvezdelina; Petkevi?ius, Saulius; Rapti, Dhimiter; Wagner, Annegret; Wagner, Thomas; Chester, S Theodore; Rosentel, Joseph; Tielemans, Eric; Visser, Martin; Winter, Renate; Kley, Katrin; Knaus, Martin

2014-04-28

75

Cosmoeducação: uma proposta para o ensino de astronomia  

NASA Astrophysics Data System (ADS)

Entende-se por cosmoeducação o desenvolvimento vivencial da unidade homem-cosmo. Este conceito é norteado pela psicologia transpessoal, que estuda o ser humano em sua totalidade, onde suas relações ecológicas e cósmicas são de grande importância. Constata-se uma necessidade latente no ser humano moderno em resgatar uma relação holística com o Universo. Neste trabalho exploramos meios de cultivar a consciência de que o ser humano constitui parte integrante do cosmo e se relaciona com este com o objetivo de promover em si uma percepção ambiental mais ampla. Nossa hipótese de trabalho inicial foi que o ensino de conteúdos básicos em astronomia realizado através de uma abordagem holística, que incorpore práticas vivenciais correlacionadas àqueles conteúdos, pode despertar no indivíduo sua identidade cósmica. O método que utilizamos é o fenomenológico e o universo desta pesquisa é um grupo de estudantes da disciplina de Astronomia (Curso de Licenciatura em Geografia/UFRN), onde realizamos observação participante, entrevistas, depoimentos e as práticas vivenciais mencionadas. Neste caso estamos desenvolvendo e adaptando exercícios de algumas técnicas terapêuticas de psicologia transpessoal, que um de nós (LALM) tem aplicado no contexto clínico, para trabalhar aspectos cognitivos envolvidos naquele processo de conscientização cósmica. Resultados parciais claramente referendam a hipótese inicial. Um resultado a destacar é fruto de uma dinâmica de representação corporal interiorizada do eclipse lunar, envolvendo um pequeno grupo daqueles estudantes, na qual conteúdos míticos afloraram de maneira espontânea e contundente para todos, sugerindo ressonância, ou pelo menos isomorfismo, entre o macro e o microcosmo. Este e outros resultados são discutidos em detalhe neste trabalho. (PPGECNM/UFRN; PRONEX/FINEP; NUPA/USP; Temáticos/FAPESP).

Medeiros, L. A. L.; Jafelice, L. C.

2003-08-01

76

A Gestão Estratégica das Instituições de Ensino Superior: uma contribuição ao melhor desempenho no caso brasileiro  

Microsoft Academic Search

Resumo: O crescimento no número de instituições de Ensino Superior no Brasil tem provocado inadequações, decorrentes da má gestão e do baixo comprometimento em relação à qualidade do processo educacional. O não alinhamento da educação superior com políticas de desenvolvimento e a falta de uma efetiva regulamentação institucional, no atendimento às demandas regionais, representam uma grave dispersão de esforços e

Alfredo Colenci Júnior; Ana Lúcia Spigolon; Marco Anselmo de Godoi; Maria Elizete Luz Sáes

77

Uma Krishnaswami and International Imaginings  

ERIC Educational Resources Information Center

This article presents an interview with South Asian children's book and young adult fiction writer, Uma Krishnaswami. The interviewer states that "in all her creative endeavors Uma's keen sense of detail, narrative voice, and characterization complicate and humanize portrayals of multicultural peoples worldwide." In this interview, Krishnaswami…

Aldama, Frederick Luis

2006-01-01

78

Trabalho emocional: o caso dos teleatendentes de uma central de atendimento  

Microsoft Academic Search

O objetivo desta pesquisa empírica sobre o trabalho e as manifestações de adoecimento em uma empresa de telecomunicações é demonstrar a necessidade de trabalho emocional, de acordo com os conceitos de Hochschild (1983) na execução de tarefas pelos teleatendentes. Tais conceitos ainda não foram devidamente explorados no Brasil, apesar de muito utilizados em diversos países. O estudo utiliza-se de dados

Lailah Vasconcelos; Ada Ávila Assunção

2007-01-01

79

Sincronizao em Sistemas Distribudos problemas clssicos  

E-print Network

problema de coordenação distribuída #12;ordenação de mensagens · implementação ­ uso de uma fila de holdback em camada de comunicação chegada de mensagens processamento (aplicação) fila entrega fila holdback destinatário responde com uma proposta de número de ordem ­ e deixa (msg, id_único, num_ordem_proposto) em fila

Rodriguez, Noemi

80

Astronomia cultural e meio ambiente segundo uma abordagem holística  

NASA Astrophysics Data System (ADS)

Neste trabalho ampliamos a discussão da abordagem holística para o ensino de astronomia que temos desenvolvido nos últimos anos, analisamos novos resultados e apresentamos exemplos práticos para interessados em experimentá-la. A constatação básica a orientar este enfoque é que cursos introdutórios em astronomia costumam ser excessiva e prematuramente técnicos, além de assumirem uma visão tradicional, muito estreita, do que seja educação científica, herdada da era cartesiana e positivista da ciência. Fundamentamos porque é importante que elementos de astronomia cultural ofereçam o mote e constituam o eixo norteador daqueles cursos e porque é urgente revermos a visão que temos da relação entre astronomia e meio ambiente. Um ponto central nesta abordagem é explorar formas de reativar e atualizar uma relação orgânica com o meio e excitar a consciência de nossa inevitável e profunda interdependência com ele em nível cósmico. Neste trabalho exemplificamos a possibilidade de concretização desta proposta em três diferentes situações: disciplinas de cursos de licenciatura em geografia e em física; escolas de nível fundamental; e, neste caso ainda a ser implementada, comunidades carentes. Estes casos envolvem públicos e espaços diferenciados para educação formal e não-formal. Dos casos já implementados, destacamos os resultados alcançados pelos alunos: enriquecimento cultural, aprendizagem significativa de conteúdos astronômicos tradicionais; mudanças de comportamento, incorporando contato diário com o céu; e freqüentes vivências de sentimentos empáticos que redirecionam a relação com a natureza e a consciência ecológica global. Além disto, para interessados em aplicar esta proposta, também socializamos procedimentos e cuidados para a implementação de ações alternativas consonantes com a mesma. (PPGECNM/UFRN; PRONEX/FINEP; NUPA/USP; Temáticos/FAPESP)

Jafelice, L. C.

2003-08-01

81

Populações estelares em galáxias HII  

NASA Astrophysics Data System (ADS)

Analisamos o conteúdo estelar de 74 galáxias HII a partir do contínuo observado nos espectros ópticos dessas galáxias, utilizando métodos de síntese de população estelar. Descobrimos que todas as galáxias para as quais encontramos soluções contêm uma população estelar velha que domina a massa estelar, e numa maioria dessas também encontramos evidência de uma população de idade intermediaria além da geração jovem que está se formando agora. Concluímos que a formação estelar dessas galáxias se realiza em surtos individuais, Esses surtos são interrompidos por longos períodos de inatividade, com os primeiros consumindo a maior parte do gás. Sugerimos, portanto, que as galáxias HII sejam galáxias anãs normais flagradas em um período de surto.

Westera, P.; Cuisinier, F.; Telles, E.; Kehrig, C.

2003-08-01

82

Halema'uma'u vent  

USGS Multimedia Gallery

Several collapses early this morning exposed more of the lava pond deep within the Halema`uma`u vent cavity. For the last several days, glowing and spattering holes (top image) have been active on the floor of the vent cavity, at a depth of about 200 m below the vent rim. At 3:06 am, a parti...

2010-06-21

83

Atendimento odontológico em gestantes: uma revisão da literatura  

Microsoft Academic Search

Many professionals of the odontological area have demonstrated concern in demystifying the popular belief, still today sufficiently common, from that pregnant woman cannot receive assistance odontological. However, still he has refusal on the part of some surgeon-dentists in giving to odontological attention the pregnant, had the controversies of opinions and deficient boarding of the subject during the academic formation, as

Vanessa Ceolin Poletto; Priscila Stona; João Batista; Blessmann Weber; Angélica Maria Genehr Fritscher

2008-01-01

84

UMA METODOLOGIA DE PLANEJAMENTO ESTRATÉGICO BASEADA EM INTELIGÊNCIA COMPETITIVA  

Microsoft Academic Search

Knowledge is one of major factors in determining the worth of modern organizations. The processes of knowledge construction are developed through data gathering and manipulation, and its transformation in useful information applicable to the improvement of organization competitiveness. These processes can be described using models of information acquisition, decision systems, and organizational strategies. In this context, this paper presents a

Paulo Sergio de Castro; Edson Satoshi Gomi; Luciano Gualberto

85

O MÉTODO PROJETUAL DE ANDREA PALLADIO UMA IMPLEMENTAÇÃO EM VBA  

Microsoft Academic Search

The aim of the present research was to study the algorithmic aspects of Palladio's design method. In the first phase of the research the different methods for calculating room proportions, proposed by Palladio in I Quattro Libri dell'Archittetura, were studied. Next, an application for AutoCAD was developed in VBA for automatically generating 3D representations of all the possible combinations of

Gabriela Celani; Bianca Tiemi Kubagawa

86

Diagnostic Performance of Schistosoma Real-Time PCR in Urine Samples from Kenyan Children Infected with Schistosoma haematobium: Day-to-day Variation and Follow-up after Praziquantel Treatment  

PubMed Central

Background In an effort to enhance accuracy of diagnosis of Schistosoma haematobium, this study explores day-to-day variability and diagnostic performance of real-time PCR for detection and quantification of Schistosoma DNA compared to other diagnostic tools in an endemic area before and after treatment. Methodology Previously collected urine samples (N?=?390) from 114 preselected proven parasitological and/or clinical S. haematobium positive Kenyan schoolchildren were analyzed by a Schistosoma internal transcribed spacer-based real-time PCR after 14 years of storage. Pre-treatment day-to-day fluctuations of PCR and microscopy over three consecutive days were measured for 24 children using intra-class correlation coefficient. A combined ‘gold standard’ (PCR and/or microscopy positive) was used to measure sensitivity and negative predictive value (NPV) of several diagnostic tools at baseline, two and 18 months post-treatment with praziquantel. Principal Findings All 24 repeatedly tested children were PCR-positive over three days with little daily variation in median Ct-values, while 83.3% were found to be egg-positive for S. haematobium at day 1 and 75.0% at day 2 and 3 pre-treatment, signifying daily fluctuations in microscopy diagnosis. Of all 114 preselected schoolchildren, repeated microscopic measurements were required to detect 96.5% versus 100% of positive pre-treatment cases by single PCR. At two months post-treatment, microscopy and PCR detected 22.8% versus 69.3% positive children, respectively. Based on the ‘gold standard’, PCR showed high sensitivity (>92%) as compared to >31% sensitivity for microscopy, both pre- and post-treatment. Conclusions/Significance Detection and quantification of Schistosoma DNA in urine by real-time PCR was shown to be a powerful and specific diagnostic tool for detection of S. haematobium infections, with less day-to-day variation and higher sensitivity compared to microscopy. The superior performance of PCR before, and two and 18 months post-treatment provides a compelling argument for PCR as an accurate and reproducible tool for monitoring treatment efficacy. PMID:24743389

Vinkeles Melchers, Natalie V. S.; van Dam, Govert J.; Shaproski, David; Kahama, Anthony I.; Brienen, Eric A. T.; Vennervald, Birgitte J.; van Lieshout, Lisette

2014-01-01

87

Marvin, robô construtor para competição em robótica móvel  

Microsoft Academic Search

renatohsp@gmail .com Resumo: Este artigo é sobre a construção do robô autônomo Marvin o Construtor, que foi construído para participar da IV Competição IEEE Brasileira de Robô. A tarefa consiste em empilhar blocos em uma área predeterminada em um menor tempo possível, ganha a torre mais alta. O robô, construído por alunos do Instituto Tecnológico de Aeronáutica (ITA), foi construído

André Martin Narciso; Carlos Augusto; Bentes da Silva; Jackson Paul Matsuura

88

Autonomia e Motivação em narrativas de aprendizes de português como língua estrangeira1  

Microsoft Academic Search

Neste artigo, discuto os resultados de minha pesquisa dentro do projeto AMFALE - Autonomia em um Modelo Fractal de Aquisição de Língua Estrangeira. Com base em conceitos de autonomia e motivação e na correlação entre eles, analiso narrativas de aprendizes de português como língua estrangeira em Belo Horizonte. Tais análises atestam que a experiência de aprendizagem inserida em uma comunidade

Fernanda Sousa Carvalho

89

21 CFR 520.1870 - Praziquantel tablets.  

...tablets to weak or debilitated animals and for assistance in the diagnosis, treatment, and control of parasitism. (B) If labeled...to weak or debilitated animals, and for assistance in the diagnosis, treatment, and control of parasitism. [46 FR...

2014-04-01

90

Imagens do céu ontem e hoje - um multimídia interativo de astronomia e uma nova exposição no MAST  

NASA Astrophysics Data System (ADS)

"Imagens do Céu Ontem e Hoje" é o título de uma nova exposição que está sendo inaugurada no Museu de Astronomia e Ciências Afins (MCT), que inclui experimentos interativos, maquetes, réplicas e 8 terminais de computador com um multimídia interativo sobre Astronomia para consulta dos visitantes. O multimídia apresenta um conteúdo bastante extenso, que engloba quase todos os temas em Astronomia, consistindo numa fonte de divulgação e pesquisa para um público que vai das crianças até estudantes universitários. O conteúdo está distribuído em mais de 500 páginas de texto divididas em 4 módulos: "O Universo", "Espectroscopia", "Telescópios" e "Observando o Céu". Cada módulo é subdividido em 5 seções, em média, cada uma iniciada por uma animação que ilustra os temas a serem abordados na seção. Ao final da animação, uma lista de temas é apresentada sob o título "Saiba Mais". Para exemplificar, o módulo "O Universo" contém as seguintes seções: "O Universo visto pelo homem", "Conhecendo o Sistema Solar", "Indo além do Sistema Solar", "Nossa Galáxia, a Via-Láctea" e "Indo mais além, a imensidão do Universo". A seção "Conhecendo o Sistema Solar", por sua vez, tem os seguintes temas: "A origem do Sistema Solar", "O Sol", "Os planetas", "Satélites, asteróides, cometas e outros bichos..." e "O Sistema Solar em números". Cada texto é repleto de imagens, quadros, desenhos, esquemas, etc, além de passatempos ao final de cada seção, incluindo jogos interativos, quadrinhos e curiosidades, que auxiliam o aprendizado de forma divertida. Apresentamos neste trabalho as idéias gerais que permearam a produção da exposição, e uma viagem pelo multimídia para exemplificar sua estrutura e conteúdo. O multimídia será posteriormente disponibilizado para o público externo pela página eletrônica do MAst e/ou por intermédio de uma publicação comercial.

Caretta, C. A.; Lima, F. P.; Requeijo, F.; Vieira, G. G.; Alves, F.; Valente, M. E. A.; de Almeida, R.; de Garcia, G. C.; Quixadá, A. C.

2003-08-01

91

Dinâmica populacional de Melanoides tuberculatus (Müller, 1774) em um riacho impactado da Vila do Abraão, Ilha Grande, Angra dos Reis, RJ, Brasil.  

E-print Network

??Melanoides tuberculatus (Müller, 1774) é um gastrópode dulceaquícola de origem afroasiática, atualmente com uma distribuição cosmopolita, devido a seu comportamento invasivo. Utilizamos em nosso trabalho… (more)

Igor Christo Miyahira

2010-01-01

92

BENJAMIN FRANKLIN E A HISTÓRIA DA ELETRICIDADE EM LIVROS DIDÁTICOS  

Microsoft Academic Search

Introdução Nos últimos anos, a história da ciência vem sendo introduzida em materiais didáticos utilizados em sala de aula. Uma das razões para isso é a pressão de órgãos governamentais, tais como a Secretaria de Educação Básica, responsável pela avaliação destes livros dentro do Programa Nacional de Livros Didáticos para o ens ino fundamental e médio. Os editais destes programas

Cibelle Celestino Silva; Ana Carolina Pimentel

93

Método numérico das diferenças finitas no domínio do tempo aplicado a ondas Alfvén em plasma astrofísico  

NASA Astrophysics Data System (ADS)

Ondas Alfvén em plasma astrofísico têm sido objeto de intenso estudo nas últimas décadas pelo fato de apresentarem papel importante em muitas áreas de pesquisa na astrofísica. Particularmente são importantes no mecanismo de aquecimento da coroa solar; em ventos estelares; em jatos galácticos e extragalácticos; em discos protoestelares, etc. A formulação para diferenças finitas no domínio do tempo (FDTD), aplicada a plasma magnetizado é desenvolvida para estudo das propriedades de ondas Alfvén em três dimensões (3D-FDTD). O método é aplicado inicialmente a um plasma homogêneo e isotérmico imerso em uma região com campo magnético externo B0, que sofre uma pequena perturbação. Uma vez gerada a onda, esta perturbação é retirada e, então analisamos a evolução temporal das ondas, bem como a forma de seu amortecimento.

Dos Santos, L. C.; Kintopp, J. A.; Jatenco-Pereira, V.; Opher, R.

2003-08-01

94

PROBLEMA, TEORIA E OBSERVAÇÃO EM CIÊNCIA : PARA UMA REORIENTAÇÃO EPISTEMOLÓGICA DA EDUCAÇÃO EM CIÊNCIA  

Microsoft Academic Search

Science teachers play an important role in forming the image of science that is held by their pupils. However, recent research suggests that quite often science teachers conceptions of the nature of scientific knowled- ge are marked by empiricist\\/inductivist epistemologies. Thus, the present paper aims to help science teachers to have a better understanding the epistemology of science aspects which

Daniel Gil-Pérez

2002-01-01

95

de Ps-Graduao em Enfermagem  

E-print Network

CAPES/PNPD A Profa. Dra Marta Lenise do Prado, docente do Programa de Pós-graduação em Enfermagem da (via e-mail), para agendar uma entrevista para arguição do currículo, considerando o perfil adequado ao

Floeter, Sergio Ricardo

96

CURRICULUM VITAE Uma Ramamurthy Department of Pediatrics  

E-print Network

CURRICULUM VITAE Uma Ramamurthy Department of Pediatrics Dan L. Duncan Institute for Clinical. Professor & Director of Research Informatics, Department of Pediatrics & Dan L. Duncan Institute's Research Hospital, Memphis, Tennessee. [June 2004 to July 2011] Director of Computing, Pediatric Brain

Ramamurthy, Uma

97

Ondas de choque em jatos de quasares e objetos BL Lacertae  

NASA Astrophysics Data System (ADS)

Este trabalho é parte de um projeto que vem sendo realizado há dois anos no CRAAM, cujos objetivos principais são analisar e aplicar um modelo generalizado de ondas de choque em jatos relativísticos de plasma, presentes em quasares e objetos BL Lacertae, para explicar a variabilidade observada nestes objetos. O método consiste em uma decomposição de curvas de luz em séries de explosões similares, em várias freqüências, baseando-se em uma evolução espectro-temporal média das explosões. A partir da evolução média, um ajuste de cada explosão é feito com base em equações empíricas, modificando-se apenas parâmetros específicos de cada explosão. Inicialmente o modelo foi aplicado ajustando-se as curvas de luz a explosões delineadas por uma evolução do choque em três estágios, segundo a predominância do processo de emissão: síncrotron, Compton e adiabático. Entretanto, nesta nova fase de projeto, visando uma parametrização mais concisa, uma otimização do algoritmo de ajuste e uma convergência mais rápida, a formulação para cada evento foi assumida com uma evolução em apenas dois estágios: subida e descida. Isto possibilitou uma ótima delineação das curvas de luz das fontes OV236, OJ287, 3C273 e BL Lac, entre 1980 e 2000, nas freqüências 4.8, 8.0, 14.5 e 22 GHz, utilizando-se dados do Observatório da Universidade de Michigan, do Observatório do Itapetinga (Atibaia SP) e do Observatório Metsähovi. Como conclusões importantes, verificou-se que: os parâmetros ajustados descrevem o comportamento do jato; os valores do índice que descreve a expansão do jato sugerem que o mesmo se expande de uma forma não-cônica; o campo magnético é turbulento atrás da frente de choque; e as peculiaridades das explosões são devidas à influência de grandezas tais como o coeficiente da distribuição espectral de energia dos elétrons, a intensidade de campo magnético e o fator de feixe Doppler, no início do choque.

Melo, F. E.; Botti, L. C. L.

2003-08-01

98

UMA/GAN network architecture analysis  

NASA Astrophysics Data System (ADS)

This paper is to critically analyze the architecture of UMA which is one of Fix Mobile Convergence (FMC) solutions, and also included by the third generation partnership project(3GPP). In UMA/GAN network architecture, UMA Network Controller (UNC) is the key equipment which connects with cellular core network and mobile station (MS). UMA network could be easily integrated into the existing cellular networks without influencing mobile core network, and could provides high-quality mobile services with preferentially priced indoor voice and data usage. This helps to improve subscriber's experience. On the other hand, UMA/GAN architecture helps to integrate other radio technique into cellular network which includes WiFi, Bluetooth, and WiMax and so on. This offers the traditional mobile operators an opportunity to integrate WiMax technique into cellular network. In the end of this article, we also give an analysis of potential influence on the cellular core networks ,which is pulled by UMA network.

Yang, Liang; Li, Wensheng; Deng, Chunjian; Lv, Yi

2009-07-01

99

GEOPROCESSAMENTO APLICADO A ECOLOGIA DE PAISAGEM: UMA ANÁLISE DA DINÂMICA ESPACIAL DA ILHA DO PAPAGAIO – PA, AMAZÔNIA-BRASIL  

Microsoft Academic Search

O geoprocessamento é uma importante ferramenta para se compreender a estrutura e a dinâmica das paisagens em diversas escalas temporais e espaciais, quando aplicado à ecologia de paisagem traz elementos tanto para o estudo das interações do homem com o meio ambiente, quanto para compreender os processos ecológicos. Dessa forma objetiva-se com este artigo, levantar as situações ambientais associadas à

Joyse Tatiane Souza dos Santos; Heriberto Wagner Amanajás Pena

2011-01-01

100

Thermal Image of Halema'uma'u  

USGS Multimedia Gallery

This image was collected from a thermal camera at the Halema`uma`u Overlook, and shows the current activity at the summit. The active lava pond, about 40 m across, is situated deep within the vent cavity, at a depth of about 200 m. The lava surface consists of slowly migrating crustal plates...

2010-06-18

101

Halema'uma'u Lava Activity  

USGS Multimedia Gallery

Spectacular eruptive activity has been occurring deep within the collapse pit in Halema`uma`u Crater at K?lauea's summit. At times, a river of lava poured into a deeper plunge pool of lava, which had a dome fountain on its right-hand side....

2010-06-21

102

Respostas posturais à perturbação externa inesperada em judocas de diferentes níveis de habilidade  

Microsoft Academic Search

RESUMO O judô é uma modalidade esportiva na qual é requerido o con- trole eficiente do equilíbrio pelo atleta, por estar constantemente sujeito a movimentos inesperados impostos por seus adversários. Este estudo teve o objetivo de analisar as respostas posturais a uma perturbação externa inesperada de judocas (n = 20) em dois níveis de habilidade (faixas marrom e verde) e

Sheylla Kyoko Yoshitomi; Clarice Tanaka; Marcos Duarte; Fernanda Lima; Edgard Morya; Fuad Hazime

2006-01-01

103

A brightening of (QSO) DR UMa  

NASA Astrophysics Data System (ADS)

The CRTS Transient (Drake et al. 2009, ApJ, 696, 870), ID CSS110402:135906+554432 has brightened in March - April 2011, it reached 17.14 mag in unfiltered images on 2011 Apr. 2.34 UT, in its normal state it is fainter than 19 mag ( http://nesssi.cacr.caltech.edu/catalina/20110402/1104021550454132704.html#table1). The object is associated with known variable star DR UMa, its SDSS magnitudes are u = 20.56, g = 20.39, r = 19.99, i = 19.98, z = 19.95, the SDSS coordinates are 13 59 05.74, 55 44 29.58 (2000). We have taken 15-min spectrum of DR UMa with the SCORPIO spectrograph of the 6-meter Russian telescope on 2011 Apr. 13.88 UT. Spectral resolution was 13 A, however the spectrum was subjected to a strong Moon background. We find DR UMa is a QSO with a redshift z = 1.01 based on a broad emission line at ~ 5630 A, which we identify with MgII 2798 A, its EW is 30 A. A comparison with SDSS QSO template spectra ( http://www.sdss.org/gallery/gal_zqso.html) reveals possible C III] 1908 A emission at our spectral range edge and other fainter emission lines. Strong absorption features at 4268, 5022/5045 and 5431 A may be MgII absorption lines arising in line of sight material.

Fabrika, S.; Barsukova, E.; Goranskij, V.; Kato, T.; Ohshima, T.; Makarov, D.; Uklein, R.; Pavlenko, E.

2011-05-01

104

Uma an?lise do fen?meno "altern?ncia de l?nguas" na fala de bil?ngues intermodais (Libras e Portugu?s)  

PubMed Central

Um interessante fenômeno lingüístico presente nas interações das pessoas bilíngues é a alternância de línguas. Neste trabalho, estamos investigando a alternância entre a língua portuguesa oral e a língua de sinais brasileira – Libras, numa mesma cadeia enunciativa, com o objetivo de identificar e analisar o uso dessa alternância na fala de uma criança e de um adulto (ambos ouvintes, filhos de pais surdos), interagindo em uma situação de bilinguismo intermodal, com interlocutores surdos e ouvintes. A alternância de línguas, nesse caso, ocorre quando se para de falar em português e se alterna para sinalizar. O presente trabalho se caracteriza como um estudo inicial, com análise qualitativa de dados. Fazem parte do nosso corpus nove sessões de interações em Libras e em português oral, gravadas em vídeo, que fazem parte do Projeto Desenvolvimento Bilíngue Bimodal da UFSC. Os dados revelam que as características da alternância de línguas pelo adulto e pela criança parecem ter semelhanças e diferenças. O sujeito adulto parece ter feito um uso da alternância mais preocupado com o curso da interação. A criança, por sua vez, não parece tê-la usado com propósitos pragmáticos específicos. Quanto à extensão das alternâncias, pode-se perceber que tanto a criança quanto o adulto utilizaram enunciados maiores do que uma única palavra isolada. O papel dos interlocutores parece ter sido decisivo nas interações aqui investigadas – especialmente nas do adulto, já que a criança ainda está em processo de tomada de consciência do papel do interlocutor na interação. PMID:24379831

de Sousa, Aline Nunes; de Quadros, Ronice Muller

2013-01-01

105

Analisando livros didáticos na perspectiva dos Estudos do Discurso: compartilhando reflexões e sugerindo uma agenda para a pesquisa  

Microsoft Academic Search

Resumo: Neste artigo, apÛs uma breve revisªo de pesquisas que tomam o livro didÆtico como objeto, delineamos os pressupostos teÛrico-metodolÛgicos de abordagens identificadas com os Estudos do Discurso e que tŒm fundamentado nossas investigaÁies sobre o livro didÆtico de ciŒncias. Em seguida, apresentamos nossas investigaÁies, que significam o livro didÆtico de ciŒncias em relaÁªo ‡s suas condiÁies sociais de produÁªo,

Isabel Martins

2006-01-01

106

Presença de dentes permanentes irrompidos em escolares da região metropolitana de Porto Alegre  

Microsoft Academic Search

RESUMO Foi realizada uma pesquisa de campo em duas escolas da rede pública estadual de Porto Alegre, com a finalidade de verificar a presença de dentes permanentes irrompidos em crian- ças com faixa etária entre seis a dez anos. Foram examinadas 327 crianças, considerando as variáveis de idade, sexo e raça. Não foi observada diferença significativa para a época de

Karine Squeff; Guilherme Pessoa Cerveira; Luciane Quadrado Closs; Jose Antônio Bosio

107

Uso de Sistemas Auto-organizados na Sntese de Materiais Auto-organizao uma das ferramentas mais versteis e mais poderosas para a  

E-print Network

exibiram estrias longitudinais em sua superfície, devido ao efeito de direcionamento da fase líquido-cristalina. As estrias parecem ser uma impressão da orientação preferencial dos arranjos cilíndricos da mesofase

Loh, Watson

108

DESENVOLVIMENTO PROFISSIONAL DA DOCÊNCIA UNIVERSITÁRIA EM OUTROS CONTEXTOS  

Microsoft Academic Search

Resumo: O intuito desta exposição é apresentar, com base na análise da experiência da RED- U - Red Estatal de Docencia Universitaria constituída por universidades espanholas, uma reflexão em torno do desenvolvimento profissional do docente universitário no atual contexto de globalização. A referida rede representa um espaço para a difusão e o intercâmbio de políticas, experiências, metodologias e ferramentas utilizadas

Solange Maria Longhi

109

QUANDO A HISTÓRIA INVADE A CENA: O CASO VLADIMIR HERZOG (RE)SIGNIFICADO POR FERNANDO PEIXOTO EM \\  

Microsoft Academic Search

Primeiramente, deve-se ressaltar que a proposta desta pesquisa (que se encontra em estágio inicial e que, portanto, muitos questionamentos são apenas apontados neste texto) é uma reflexão sobre a encenação do espetáculo teatral Ponto de Partida de Gianfrancesco Guarnieri, em 1976, no Teatro TAIB (SP), numa produção de Othon Bastos Produções Artísticas e Documenta Produções Artísticas. Neste sentido, tais análises

Ludmila Sá de Freitas

110

A gente mora na estrada e passeia em casa: Carga Pesada, um road-movie na TV  

Microsoft Academic Search

Resumo: O artigo em questão volta-se para uma análise do programa de televisão Carga Pesada, exibido pela Rede Globo de Televisão, distinguindo os dois períodos em que foi produzido e exibido - início da década de 80 e atual. Trata-se de compreender quais são suas influências e que estratégias de linguagens são absorvidas pelo programa. Sua relação com o cinema

FELIPE MUANIS

111

Thermal Image of Halema'uma'u Crater  

USGS Multimedia Gallery

This thermal image (white is hot, dark blue is cold), taken during today's helicopter overflight, shows the current vent configuration at Halema`uma`u crater. The vent cavity is about 130 meters (430 ft) wide, and has consumed portions of the wall and floor of Halema`uma`u crater. Th...

2010-06-18

112

UMA Media base Metadata Management using Oracle Database System  

E-print Network

UMA Media base ­ Metadata Management using Oracle Database System R.J. Solberg1 , P. Drege1 , A describes the media base in a Universal Multimedia Access (UMA) test bed for handling multimedia presentations in an MPEG-21 environment. The media base introduces an effective way of storing, query organiz

Nørvåg, Kjetil

113

Evolução temporal de discos circunstelares em estrelas Be  

NASA Astrophysics Data System (ADS)

A pesquisa do mecanismo que leva uma estrela do tipo Be a perder massa e formar um envelope circunstelar, nomeado como fenômeno Be, é uma questão em aberto, intrigante, e que adquire contornos interessantes em face às informações espectroscópicas de alta resolução. Nesta última década, consolida-se a idéia de que a forma destes envelopes é de tipo discóide, obedecendo a uma lei Kepleriana de velocidades, e mais ainda, recentemente há evidências de que a distribuição de matéria nestes discos pode assumir um caráter de anel. Medidas de algumas dimensões de discos circunstelares puderam ser obtidas pela análise de espectros de alta resolução e alta relação sinal-ruído para as estrelas Be: alpha Eri (HD 10144, B3Vpe), omicron And (HD 217675, B6IIIpe), e eta Cen (HD el972, B1.5Vne), no período dos anos de 1991 a 2001. Alguns modelos clássicos de envelope predizem uma distribuição de massa que decresce suavemente a partir da superfície estelar. Entretanto, considerando que a separação de picos de emissão em perfis de linhas do HeI e H-alpha, alargados por efeitos cinemáticos, é função do raio estelar e da velocidade rotacional projetada (vsini); nossos resultados sugerem a presença de um anel de matéria circunstelar, que aparece logo após a ejeção do material fotosférico, imediatamente acima da superfície estelar, e que se expande para raios maiores ao longo do tempo, eventualmente desconectando-se da superfície por uma região de densidade de matéria mínima. Tais interpretações revivem a idéia de que anéis de matéria circunstelar podem ser os responsáveis por algumas variabilidades em perfis de linhas de emissão, como as variações V/R.

Fernandes, M. V. M.; Leister, N. V.; Levenhagen, R. S.

2003-08-01

114

Astronomia para/com crianças carentes em Limeira  

NASA Astrophysics Data System (ADS)

Em 2001, o Instituto Superior de Ciências Aplicadas (ISCA Faculdades de Limeira) iniciou um projeto pelo qual o Observatório do Morro Azul empreendeu uma parceria com o Centro de Promoção Social Municipal (CEPROSOM), instituição mantida pela Prefeitura Municipal de Limeira para atender crianças e adolescentes carentes. O CEPROSOM contava com dois projetos: Projeto Centro de Convivência Infantil (CCI) e Programa Criança e Adolescente (PCA), que atendiam crianças e adolescentes em Centros Comunitários de diversas áreas da cidade. Esses projetos têm como prioridades estabelecer atividades prazerosas para as crianças no sentido de retirá-las das ruas. Assim sendo, as crianças passaram a ter mais um tipo de atividade - as visitas ao observatório. Este painel descreve as várias fases do projeto, que envolveu: reuniões de planejamento, curso de Astronomia para as orientadoras dos CCIs e PCAs, atividades relacionadas a visitas das crianças ao Observatório, proposta de construção de gnômons e relógios de Sol nos diversos Centros Comunitários de Limeira e divulgação do projeto na imprensa. O painel inclui discussões sobre a aprendizagem de crianças carentes, relatos que mostram a postura das orientadoras sobre a pertinência do ensino de Astronomia, relatos do monitor que fez o atendimento no Observatório e o que o número de crianças atendidas representou para as atividades da instituição desde o início de suas atividades e, em particular, em 2001. Os resultados são baseados na análise de relatos das orientadoras e do monitor do Observatório, registros de visitas e matérias da imprensa local. Conclui com uma avaliação do que tal projeto representou para as Instituições participantes. Para o Observatório, em particular, foi feita uma análise com relação às outras modalidades de atendimentos que envolvem alunos de escolas e público em geral. Também é abordada a questão do compromisso social do Observatório na educação do público em questão.

Bretones, P. S.; Oliveira, V. C.

2003-08-01

115

Ansiedade, dor e desconforto relacionado à saúde bucal em crianças menores de 5 anos Anxiety, pain and discomfort related to oral health in children under the age of five years  

Microsoft Academic Search

Key-words Essa pesquisa teve como objetivo avaliar a ansiedade, dor e\\/ ou desconforto associado à saúde bucal em crianças menores de 5 anos. Participaram deste estudo piloto 83 crianças, de ambos os sexos, matriculadas em uma creche municipal, no bairro de Santo Amaro, Recife. A coleta de dados foi realizada através da aplicação de um questionário em forma de entrevista

Michelle Marie; Tiné Oliveira; Viviane Colares; Amanda Campioni

116

DESEMPENHO DE UMA APLICAÇÃO DE TRANSFERÊNCIA DE ARQUIVOS EM UM SISTEMA DE COMUNICAÇÃO INDUSTRIAL  

Microsoft Academic Search

This paper presents and analyses a low cost manufacturing communication system and provides performance measures for a file transfer application. It consists in the standard TOP profile implemented on a personal computer connected to a IEEE 802.3 LAN. High throughput is achieved by an efficient implementation architecture. Performance measurement results show a throughput efficiency that attains, for Application Layer (FTAM)

Daniel Antunes; Maciel Villela; Célio Vinicius; Luís Henrique; Kosmalski Costa; Marcelo Dias Nunes

117

tica e justia nas pesquisas sediadas em comunidades: o caso de uma pesquisa  

E-print Network

,emuitoparticularmenteaquelesdebeneficênciaedejustiça.Essegênerodepráticacientífica implica um desdobramento da responsabilidade dos pesquisadores, entre a pesquisa e a ação. Palavras envolvidos. Segundo o caso, chama-se aos grupos concernidos de "comunidades", "sociedade civil" ou "público esclarecimento da esfera de responsabilidade dos pesquisadores. 1 As pesquisas participativas: qualidades e

Paris-Sud XI, Université de

118

INTELIGÊNCIA COMPETITIVA: ESTUDO DE CASO EM UMA COOPERATIVA AGROINDUSTRIAL DO ESTADO DO PARANÁ  

Microsoft Academic Search

Competitive Intelligence (CI) can be an effective tool for the decisions taking, that is, its usefulness, form of dissemination, and use in organizations. The CI contributes to the organization in several aspects and its capacity of competing with each other, whereas it provides knowledge about the inside and outside environment. The main goal of this article is analizing the importance

Silvio Roberto Stefano

2008-01-01

119

Análise dos impactos ambientais do turismo em uma área protegida na Amazônia  

Microsoft Academic Search

The obtained data represent a reflection of the insert of the tourism in an U.C. in the Amazonian as alternative for the local populations and mechanism of protection of the natural resources. The research was materialized in two stages: for the participant observation and for the application of forms. In the first stage a description of low environmental degradation was

T UA

120

O itinerário rumo às medicinas alternativas: uma análise em representações sociais de profissionais da saúde  

Microsoft Academic Search

This article focuses on social representations of alternative medicines by a group of professors from the School of Medicine and health professionals from the public health system in the city of Campinas, São Paulo, basically physicians and nurses. The article also emphasizes personal trajectories by which these health professionals opted for a dissident theoretical and practical perspective vis-à-vis the hegemonic

Marcos S. Queiroz

2000-01-01

121

UMA ANÁLISE DAS CONTRIBUIÇÕES DO BASQUETEBOL EM CADEIRAS DE RODAS PARA PRATICANTES COM DEFICIÊNCIAS  

Microsoft Academic Search

This study aimed to analyze the contributions of basketball in wheelchairs for participants with deficiencies. The sample was constituted by ten people, male, more than twenty years-old, integrants of basketball team for wheelchairs sport makers in Ch apeco (Santa Catarina, Brazil). It was made observations of trainees and middle-structured interviews applied individually. It was observed that the practice of this

Emerson Lupe da Costa

122

A Fragilidade das Empresas de Base Tecnológica em Economias Periféricas: uma interpretação baseada na experiência brasileira  

Microsoft Academic Search

This paper aims at analysing the restraints to the creation, maturation and growth of technology-based firms (TBF) in developing countries. Although the argument is empirically based on the experience of the Brazilian economy, we do believe the analysis may apply to a much wider universe as regarding most countries in the periphery of world economy. We propose a microeconomic approach

MARCELO PINHO; MAURO ROCHA CÔRTES; ANA CRISTINA FERNANDES

123

Uma nova espécie de Trichodina Ehrenberg, 1838 (Ciliophora: Trichodinidae) em Biomphalaria schrammi (Crosse, 1864) (Mollusca: Planorbidae)  

Microsoft Academic Search

A new species of Trichodina Ehrenberg, 1838 (Ciliophora: Peritrichida) in Biomphalaria schrammi (Crosse, 1864) (Mollusca: Gastropoda). A new species of Peritrichida found in Biomphalaria schrammi (Crosse, 1864) is described. This new species is characterized by a reticular central area of the adhesive disc and a horseshoe-shaped macronucleus, a 80.0 ± 7 µm-diameter celular body and a 41.4 ± 2.9 µm

Hudson A. Pinto; Alfredo H. Wieloch; Alan L de Melo

124

AMBIENTE DE EXPERIMENTAÇÃO EM MANIPULAÇÃO ROBÓTICA USANDO UMA ESTAÇÃO ROBÓTICA EDUCACIONAL E PROGRAMAÇÃO MATLAB  

Microsoft Academic Search

This article describes a locally developed robotic station for experiences in object manipulation. The station was implemented around the mechanical structure of the Rhino XR4 robot, having developed a multi-axis controller and a programming interface. Due to the facilities in mathematical processing and visual representation the Matlab computational environment was now chosen. A Matlab toolbox (Rhinobox) was de- veloped what

Humberto A. Guimarães; Frederico F. Elsner; V. H. Casanova Alcalde

125

Fenologia reprodutiva de espécies arbóreas em uma formação secundária da floresta Atlântica  

Microsoft Academic Search

Studies on reproductive phenology of tree species provide the knowledge needed to define strategies for forest conservation and management. Thus, the objective of this work was to characterize the reproductive phenology of woody species in secondary forests of the Atlantic Rain Forest. From June\\/1998 to July\\/1999, flowering and fructification periods of five to 41 reproductive trees of 19 species were

Marcelo Mantovani; Ademir Roberto Ruschel; Maurício Sedrez dos Reis; Ângelo Puchalski; Rubens Onofre Nodari

2003-01-01

126

ALMOÇO COMO MOMENTO TERAPÊUTICO: UMA ABORDAGEM DE EDUCAÇÃO EM SAÚDE COM MULHERES ALCOOLISTAS  

Microsoft Academic Search

The alcoholism is a relevant problem in public health. The use of alcohol among women has increased as well as the search for treatment. This research proposes the resignification of food to these women, as a harm reduction strategy. The research aimed to study and to discuss the experience of lunchtime as a therapeutic moment, presenting theoretic assumptions, strategies and

Silzeth Schlichting; Maria Cristina Faber Boog; Claudinei José Gomes Campos

2007-01-01

127

CONVERSÃO DE CAPOEIRAS EM POVOAMENTOS DE PINHEIRO-DO-PARANÁ: UMA AVALIAÇÃO ECONÔMICA  

Microsoft Academic Search

In the State of Paraná, and also in the grather part of the Center-South region in Brazil, there are areas coverd with secondary vegetation of low wood value. Ignoring forest species that can be planted with initial and partial shading has greatly obstructed better uses for these forests. This paper had as objective to economically evaluate the process of artificial

Vitor Afonso Hoeflich; Luiz Roberto Graça; Paulo Ernani; Ramalho Carvalho

128

21 CFR 520.1198 - Ivermectin and praziquantel paste.  

...Hairworms (adults)—Trichostrongylus axei ; Large-mouth Stomach Worms (adults)—Habronema muscae ; Bots (oral and gastric...Hairworms (adults)—Trichostrongylus axei ; Large-mouth Stomach Worms (adults)—Habronema muscae ; Bots (oral and...

2014-04-01

129

21 CFR 520.1198 - Ivermectin and praziquantel paste.  

Code of Federal Regulations, 2011 CFR

...Hairworms (adults)—Trichostrongylus axei ; Large-mouth Stomach Worms (adults)—Habronema muscae ; Bots (oral and gastric...Hairworms (adults)—Trichostrongylus axei ; Large-mouth Stomach Worms (adults)—Habronema muscae ; Bots (oral and...

2011-04-01

130

21 CFR 520.1453 - Moxidectin and praziquantel gel.  

Code of Federal Regulations, 2013 CFR

...adults and L4 larval stages); hairworms: Trichostrongylus axei (adults); large-mouth stomach worms: Habronema muscae (adults); horse stomach bots: Gasterophilus intestinalis (2nd and 3rd instars) and G . nasalis (3rd...

2013-04-01

131

21 CFR 520.1453 - Moxidectin and praziquantel gel.  

Code of Federal Regulations, 2012 CFR

...adults and L4 larval stages); hairworms: Trichostrongylus axei (adults); large-mouth stomach worms: Habronema muscae (adults); horse stomach bots: Gasterophilus intestinalis (2nd and 3rd instars) and G . nasalis (3rd...

2012-04-01

132

21 CFR 520.1453 - Moxidectin and praziquantel gel.  

Code of Federal Regulations, 2011 CFR

...adults and L4 larval stages); hairworms: Trichostrongylus axei (adults); large-mouth stomach worms: Habronema muscae (adults); horse stomach bots: Gasterophilus intestinalis (2nd and 3rd instars) and G . nasalis (3rd...

2011-04-01

133

21 CFR 520.1198 - Ivermectin and praziquantel paste.  

Code of Federal Regulations, 2012 CFR

...Hairworms (adults)—Trichostrongylus axei ; Large-mouth Stomach Worms (adults)—Habronema muscae ; Bots (oral and gastric...Hairworms (adults)—Trichostrongylus axei ; Large-mouth Stomach Worms (adults)—Habronema muscae ; Bots (oral and...

2012-04-01

134

21 CFR 520.1198 - Ivermectin and praziquantel paste.  

Code of Federal Regulations, 2013 CFR

...Hairworms (adults)—Trichostrongylus axei ; Large-mouth Stomach Worms (adults)—Habronema muscae ; Bots (oral and gastric...Hairworms (adults)—Trichostrongylus axei ; Large-mouth Stomach Worms (adults)—Habronema muscae ; Bots (oral and...

2013-04-01

135

21 CFR 520.1453 - Moxidectin and praziquantel gel.  

...adults and L4 larval stages); hairworms: Trichostrongylus axei (adults); large-mouth stomach worms: Habronema muscae (adults); horse stomach bots: Gasterophilus intestinalis (2nd and 3rd instars) and G. nasalis (3rd...

2014-04-01

136

21 CFR 520.1453 - Moxidectin and praziquantel gel.  

Code of Federal Regulations, 2010 CFR

...capitatus ; and Petrovinema poculatus ; small strongyles: undifferentiated lumenal larvae; encysted cyathostomes (late L3 and L4 mucosal cyathostome larvae); ascarids: Parascaris equorum (adults and L4 larval stages); pinworms:...

2010-04-01

137

21 CFR 520.1198 - Ivermectin and praziquantel paste.  

Code of Federal Regulations, 2010 CFR

...Petrovinema poculatum ; Small Strongyles—fourth-stage larvae; Pinworms (adults and fourth-stage larvae)—Oxyuris equi ; Ascarids (adults and third- and fourth-stage larvae)—Parascaris equorum ; Hairworms...

2010-04-01

138

21 CFR 524.775 - Emodepside and praziquantel.  

Code of Federal Regulations, 2010 CFR

...caused by Ancylostoma tubaeforme (adults, immature adults, and fourth stage larvae), roundworm infections caused by Toxocara cati (adults and fourth stage larvae), and tapeworm infections caused by Dipylidium caninum (adults) and...

2010-04-01

139

21 CFR 520.1199 - Ivermectin, pyrantel, and praziquantel tablets.  

Code of Federal Regulations, 2010 CFR

...of tablets. (2) Indications for use . Prevents canine heartworm disease by eliminating the tissue stage of heartworm larvae (Dirofilaria immitis ) for 1 month (30 days) after infection and for the treatment and control of roundworm...

2010-04-01

140

21 CFR 520.1445 - Milbemycin oxime and praziquantel.  

Code of Federal Regulations, 2013 CFR

...Ancylostoma caninum ), adult whipworm (Trichuris vulpis ), and adult tapeworm (Taenia pisiformis, Echinococcus multilocularis, and E. granulosus ) infections in dogs and puppies 2 pounds of body weight or greater and 6 weeks...

2013-04-01

141

21 CFR 520.1445 - Milbemycin oxime and praziquantel.  

...Ancylostoma caninum ), adult whipworm (Trichuris vulpis ), and adult tapeworm (Taenia pisiformis, Echinococcus multilocularis, and E. granulosus ) infections in dogs and puppies 2 pounds of body weight or greater and 6 weeks...

2014-04-01

142

Colquio em homenagem ao centenrio da morte de Henri Poincar Rio de Janeiro  

E-print Network

Colóquio em homenagem ao centenário da morte de Henri Poincaré Rio de Janeiro 27 a 30 de novembro Henri Poincaré (Université Nancy 2) Em 2012, ocorrerá o primeiro centenário da morte do matemático morte de Poincaré, além de ser uma merecida homenagem a um cientista-filósofo, cujas idéias ainda hoje

Solodov, Mikhail V.

143

VIOLÊNCIA CONTRA CRIANÇAS E ADOLESCENTES NEGROS: UMA ABORDAGEM HISTÓRICA VIOLENCE AGAINST BLACK CHILDREN AND TEENAGERS: A HISTORIC OVERVIEW VIOLENCIA CONTRA LOS NIÑOS Y LOS ADOLESCENTES NEGROS: UN ABORDAJE HISTÓRICO  

Microsoft Academic Search

RESUMO: Trata- se de um estudo bibliográfico com o objetivo de historicizar a prática da violência contra crianças e adolescentes negros desde os tempos coloniais em que o sistema escravagista impetrava atos da mais extrema violência contra o ser humano. Busca uma melhor compreensão da magnitude do problema, descreve alguns conceitos e apresenta vários enfoques da violência num contexto interdisciplinar,

Climene Laura de Camargo; Eloina Santana Alves; Marinalva Dias Quirino

2005-01-01

144

Levantamento e diagnóstico de uma ponte metálica antiga.  

E-print Network

??Tese de mestrado integrado. Engenharia Civil (Especialização em Estruturas). Faculdade de Engenharia. Universidade do Porto, Faculdade de Engenharia. Universidade de Palermo. 2010 Advisors/Committee Members: (more)

Meireles, António Pedro Conde

2012-01-01

145

EM International. Volume 1  

SciTech Connect

It is the intent of EM International to describe the Office of Environmental Restoration and Waste Management`s (EM`s) various roles and responsibilities within the international community. Cooperative agreements and programs, descriptions of projects and technologies, and synopses of visits to international sites are all highlighted in this semiannual journal. Focus on EM programs in this issue is on international collaboration in vitrification projects. Technology highlights covers: in situ sealing for contaminated sites; and remote sensors for toxic pollutants. Section on profiles of countries includes: Arctic contamination by the former Soviet Union, and EM activities with Germany--cooperative arrangements.

Not Available

1993-07-01

146

Period Study of the Contact Binary AW UMa  

NASA Astrophysics Data System (ADS)

The orbital period changes of the contact binary AW UMa are investigated, and a secular period decrease of the order of -2.0 × 10-2 s y-1 was detected. It was found that the wave-like shape of the observed period changes of AW UMa can be fitted either with one sinusoidal periodic term of 29 y with amplitude 1.25 × 10-6d, or they could be the result of multiple periodic terms. The latter might not be real, as they correspond to the time interval for which observational data exist as well as to its sub-multiplicities. This might explain the different periodicities proposed up to now for the AW UMa by various investigators, and certainly more data are needed to get reliable results.

Rovithis-Livaniou, H.; Tsantilas, S.; Kalimeris, A.; Rovithis, P.; Djurasevic, G.; Voloshina, I.

2005-07-01

147

Concepções de policiais sobre crianças em situação de rua: um estudo sobre preconceito  

Microsoft Academic Search

Resumo O objetivo deste estudo foi investigar a concepção que policiais militares têm das crianças em situação de rua. Pela técnica da inserção ecológica, doze policiais homens foram selecionados ao acaso e entrevistados nas ruas perante um roteiro pré-estabelecido. Foi realizada uma análise qualitativa do conteúdo das entrevistas e de diários de campo dos pesquisadores. Os critérios utilizados pelos policiais

Elder Cerqueira-Santos; Sílvia H. Koller; Christian Pilz; Daniela D. Dias; Flávia Wagner

2006-01-01

148

Photometric and polarimetric studies of three W UMa-type binaries: FZ Ori, V407 Peg and LP UMa  

NASA Astrophysics Data System (ADS)

We present analyses of new optical photometric observations of three W UMa-type contact binaries FZ Ori, V407 Peg and LP UMa. Results from the first polarimetric observations of the FZ Ori and V407 Peg are also presented. The periods of FZ Ori, V407 Peg and LP UMa are derived to be 0.399986, 0.636884 and 0.309898 d, respectively. The O- C analyses indicate that the orbital periods of FZ Ori and LP UMa have increased with the rate of 2.28×10-8 and 1.25×10-6 d yr-1, respectively and which is explained by transfer of mass between the components. In addition to the secularly increasing rate of orbital period, it was found that the period of FZ Ori has varied in sinusoidal way with oscillation period of ˜30.1 yr. The period of oscillations are most likely to be explained by the light-time effect due to the presence of a tertiary companion. Small asymmetries have been seen around the primary and secondary maxima of light curves of all three systems, which is probably due to the presence of cool/hot spots on the components. The light curves of all three systems are analysed by using Wilson-Devinney code (WD) and the fundamental parameters of these systems have been derived. The present analyses show that FZ Ori is a W-subtype, and V407 Peg and LP UMa are A-subtype of the W UMa-type contact binary systems. The polarimetric observations in B, V, R and I bands, yield average values of polarization to be 0.26±0.03, 0.22±0.02, 0.22±0.03 and 0.22±0.05 per cent for FZ Ori and 0.21±0.02, 0.29±0.03, 0.31±0.01 and 0.31±0.04 per cent for V407 Peg, respectively.

Prasad, Vinod; Pandey, J. C.; Patel, M. K.; Srivastava, D. C.

2014-10-01

149

Memory Systems for Cognitive Agents Uma Ramamurthy1  

E-print Network

Memory Systems for Cognitive Agents Uma Ramamurthy1 and Stan Franklin2 Abstract. The several different memory systems in human beings play crucial roles in facilitating human cognition. To build and cognitive science. In this paper we describe the various memory systems in the LIDA Architecture, which

Ramamurthy, Uma

150

A formulação da nova política de saúde no Brasil em tempos de democratização : entre uma conduta estatista e uma concepção societal de atuação política  

Microsoft Academic Search

O presente artigo tem por objetivo traçar o perfil dos atores constitutivos do movimento de saúde no Brasil a partir de meados da década de 70, focalizando seus aportes institucionais, nexos organizativos e articulações discursivas, com vistas a aferir o papel destes atores na formulação da nova política nacional de saúde no período da democratização. Como parte deste objetivo, pretendemos

Ana Maria Doimo; Marta M. Assumpção Rodrigues

151

Inexistência de Diferenças de Sexo no Fator g (Inteligência Geral) e nas Habilidades Específicas em Crianças de Duas Capitais Brasileiras There are no Sex Differences on g Factor and Specific Abilities in Children from Two Brazilian Capitals  

Microsoft Academic Search

Resumo O presente trabalho pretendeu examinar diferenças relacionadas ao sexo no fator g (inteligência geral) e em habilidades específicas em crianças de duas cidades brasileiras: Belo Horizonte e Porto Alegre. No caso da amostra mineira (n=1,316), a idade compreendeu entre 5 e 11 anos de idade examinada através de uma bateria de testes a qual incluiu instrumentos de inteligência (Raven,

Carmen E. Flores-Mendoza; Marcela Mansur-Alves; Álvaro José Lelé; Denise Ruschel Bandeira

152

RESSEGURO DE RESPONSABILIDADE CIVIL GERAL: AVALIAÇÃO DE UMA ESTRATÉGIA  

Microsoft Academic Search

Neste trabalho, torna-se a carteira de Responsabilidade Civil Geral de uma companhia de seguros e procura determina-se os modelos probabilísticos adequados para a caracterização: a) do número de indemnizações produzidas anualmente por cada apólice; b) dos montantes dessas indemnizações. Considera-se de seguida a estratégia de resseguro adaptada pela Companhia (resseguro não proporcional, do tipo Excess of Loss), formaliza-se o modelo

Onofre Alves Simões; Delminda Luisa Rangel Amado

2001-01-01

153

IX Draconis, ER UMa-type dwarf nova  

NASA Astrophysics Data System (ADS)

We present results of our world-wide observing campaign which was dedicated to one of the most active dwarf novae, IX Draconis. We investigated photometric behaviour of the system to derive its basic parameters. This study is important in the context of our understanding of the accretion process of IX Draconis, as well as other active cataclysmic variables, especially those from the still poorly studied type of ER UMa stars.

Otulakowska-Hypka, M.; Olech, A.; de Miguel, E.; Rutkowski, A.; Koff, R.; Bakowska, K.

2013-02-01

154

EMS in the pueblos.  

PubMed

Imagine creating a movie by excerpting scenes from "Dances With Wolves," splicing it with footage from "Code 3" or "Emergency Response" and then flavoring the script with the mystery of a Tony Hillerman novel. A film producer would probably find it quite difficult to choreograph a finished product from such a compilation of material. To hundreds of Native American EMS providers, however, such a movie is played out every day in Indian country. And with this movie come some real-life problems, including trauma, which is the number-one cause of premature death among Native Americans. But a high trauma rate is just one of the challenges facing tribal EMS responders. There's also prolonged response and transport, the problems involved in maintaining the unique culture and standard of care, the challenges of tribal EMS administration and EMS education of Native American students, and the unsure future of Native American EMS. Beyond that, there's the fact that EMS is a s unique to each Indian reservation as are the cultures of the native peoples who reside on these lands. Yet while no two systems are alike, most tribal EMS providers face similar challenges. PMID:10131740

Vigil, M A

1994-02-01

155

Relações solo-geoambiente em áreas de ocorrências de Ipucas na planície do Médio Araguaia - Estado de Tocantins  

Microsoft Academic Search

RESUMO - Dentre as paisagens do médio rio Araguaia, destacam-se as extensas planícies e depressões sazonalmente alagadas. Nelas se inserem formações florestais higrófilas denominadas Ipucas, como enclaves peculiares pela sua fitossociologia e ambiente pedogeomorfológico. Esses fragmentos florestais naturais ocorrem na planície fluvial, em região de ecótono entre o Cerrado e a Floresta Amazônica. Neste estudo, foi selecionada uma área de

Alan Kardec Elias Martins; Carlos Ernesto G. R. Schaefer; Elias Silva; Vicente Paulo Soares; Guilherme Resende Corrêa; Bruno Araújo Furtado de Mendonça

2006-01-01

156

ANALISE COMPARATIVA ENTRE MICROSOFT FLIGHT SIMULATOR E FLIGHTGEAR FLIGHT SIMULATOR EM TESTES HARDWARE-IN-THE-LOOP  

E-print Network

testes HWIL estende-se `as diversas ´areas de pesquisa, auxiliando a minimi- zar o tempo e os custosAN´ALISE COMPARATIVA ENTRE MICROSOFT FLIGHT SIMULATOR E FLIGHTGEAR FLIGHT SIMULATOR EM TESTES, HWIL systems, UAVs, simulation. Resumo-- Neste artigo ´e estabelecida uma rela¸c~ao comparativa entre

Chaimowicz, Luiz

157

Environmental Media Services (EMS)  

NSDL National Science Digital Library

Environmental Media Services (EMS) is a nonprofit communications clearinghouse committed to the expansion of media coverage on critical environmental and public health issues. True to their mission, EMS staff "build relationships with top scientists, physicians, and other experts to bring journalists the latest and most credible information." EMS's modest homepage is free of clutter but full of content. While several sections are under construction and updates (currently) appear irregular, a series of available articles provides useful summaries of important environmental news issues over the past six months. Current articles include "The impacts of global warming on the oceans" and "Cool companies," among others.

158

Relações Brasil-Argentina: Uma análise dos avanços e recuos  

Microsoft Academic Search

Nada há de original em afirmar que as relações Brasil-Argentina foram erráticas durante grande parte da História. A real dimensão das convergências e divergências é, contudo, menos evidente. Este artigo tenta examinar de forma objetiva os ciclos de avanços e recuos, conforme esquematizado no gráfico ao lado. A política externa argentina sempre sofreu impulsos contraditórios de dependência e autonomia, isolacionismo

Alessandro Warley Candeas

2005-01-01

159

Exames peridicos de sade so uma realidade na UFPR  

E-print Network

A reivindicação é antiga, mas agora conta com recursos financeiros do Ministério do Planejamento Celsina Favorito. Para que esta antiga reivindicação dos ser- vidores públicos federais fosse colocada em prática, o

Paraná, Universidade Federal do

160

Código para imageamento indireto de estrelas em sistemas binarios: simulação de variações elipsoidais e do perfil das linhas  

NASA Astrophysics Data System (ADS)

As estrelas secundárias em variáveis cataclí smicas (VCs) e binárias-x de baixa massa (BXBMs) são cruciais para o entendimento da origem, evolução e comportamento destas binárias interagentes. Elas são estrelas magneticamente ativas submetidas a condições ambientais extremas [e.g., estão muito próximas de uma fonte quente e irradiante; têm rotação extremamente rápida e forma distorcida; estão perdendo massa a taxas de 10-8-10-10 M¤/ano] que contribuem para que suas propriedades sejam distintas das de estrelas de mesma massa na seqüência principal. Por outro lado, o padrão de irradiação na face da secundária fornece informação sobre a geometria das estruturas de acréscimo em torno da estrela primária. Assim, a obtenção de imagens da superfície destas estrelas é de grande interesse astrofísico. A Tomografia Roche usa as variações no perfil das linhas de emissão/absorção da estrela secundária em função da fase orbital para mapear a distribuição de brilho em sua superfície. Neste trabalho apresentamos os resultados iniciais do desenvolvimento de um programa para o mapeamento da distribuição de brilho na superfí cie das estrelas secundárias em VCs e BXBMs com técnicas de astro-tomografia. Presentemente temos em operação um código que simula as variações no perfil das linhas em conseqüência de efeito Doppler resultante da combinação de rotação e translação de uma estrela em forma de lobo de Roche em torno do centro de massa da binária, em função da distribuição de brilho na superfície desta estrela. O código igualmente produz a curva de luz resultante das variações de aspecto da estrela em função da fase orbital (variações elipsoidais).

Souza, T. R.; Baptista, R.

2003-08-01

161

MODELAGEM DE CHEGADAS EM FILAS GI[X]/M/C/K VIA NCLEO-ESTIMADORES  

E-print Network

MODELAGEM DE CHEGADAS EM FILAS GI[X]/M/C/K VIA N�CLEO-ESTIMADORES F. R. B. Cruz, A. R. Duarte, N. L A incorporação da estimação estatística na análise de filas finitas é uma ideia interessante e promissora como tamanho do sistema. Os resultados são animadores. Palavras-Chave: estatística, sistemas de filas, núcleo

Cruz, Frederico

162

EM Radiation Program  

NSDL National Science Digital Library

The EM Radiation program displays the electric field vectors (in the x-y plane) and magnetic field contours (for the field in the z direction) calculated from the Lienard-Wiechert potentials for a charged particle. The default scenario shows the resulting radiation from a charged particle in simple harmonic motion. Additional particle trajectories can be specified using the Display | Switch GUI menu item. EM Radiation is an Open Source Physics program written for the teaching of electromagnetism. It is distributed as a ready-to-run (compiled) Java archive. Double clicking the em_radiation.jar file will run the program if Java is installed. Other electromagnetism programs are also available. They can be found by searching ComPADRE for Open Source Physics, OSP, or electromagnetism.

Christian, Wolfgang

2008-05-20

163

O Que o Pediatra Pode e Deve Fazer Diante de Uma Criança com Ambigüidade Genital?  

Microsoft Academic Search

O momento do nascimento de uma criança reveste-se de expectativas e de festas. Todo casal que vai à maternidade aguarda por um momento feliz, alegre, onde seu filho(a) irá nascer. Neste contexto, quando o Pediatra ou o Neonatologista que atende essa criança constata uma ambigüidade genital, cria-se uma sensação de pânico que, às vezes, inconscientemente, é traduzida numa perigosa resposta

Durval Damiani; Gil Guerra Jr

164

Tabaco, álcool e outras drogas entre adolescentes em Pelotas, Rio Grande do Sul, Brasil: uma perspectiva de gênero  

Microsoft Academic Search

This study assesses the relationship between gender and use of psychoactive substances (al- cohol, nicotine, and illicit drugs) by teenagers. In 2002, a cross-sectional study was carried out in the urban area of Pelotas, southern Brazil. Multi-stage sampling was used to obtain a sam- ple of adolescents, 15 to 18 years of age. Subjects were interviewed using a self-applied confiden-

Rogério Lessa Horta; Bernardo Lessa Horta; Ricardo Tavares Pinheiro; Blanca Morales; Marlene Neves Strey

2007-01-01

165

DESENVOLVIMENTO E IMPLEMENTAÇÃO DE UMA BASE COMPUTACIONAL ORIENTADA A OBJETOS PARA APLICAÇÕES EM SISTEMAS DE ENERGIA ELÉTRICA  

Microsoft Academic Search

This paper describes the application of the Object-Oriented Programming (OOP) on the modeling of Power Systems. It is intend to develop a computational object-oriented base to represent, in an efficient way, the physical component s of a Power System and their methodologies of analysis and synthesis. The generalization level of the classes' structure allows fut ure specializations, on the side

MARCELO N. AGOSTINI; ILDEMAR C. DECKER; AGUINALDO S. E SILVA

2000-01-01

166

ADMINISTRAÇÃO DE INSULINA: UMA ABORDAGEM FUNDAMENTAL NA EDUCAÇÃO EM DIABETES. ADMINISTRATION OF INSULIN: A BASICAL BROACHING IN DIABETES EDUCATION  

Microsoft Academic Search

The present study aims at accomplishing a review in the literature about the administration of insulin, considering relevant topics such as: insulin actions, local cutaneous complications, use of the instruments for the administration of insulin, the dismissable syringe and its re-utilization and the administration of insulin technique, being these basical terms to be broached in educational programs of diabetes.

Carla Regina de Souza; Maria Lúcia Zanetti

167

IX Draconis - a curious ER UMa-type dwarf nova  

NASA Astrophysics Data System (ADS)

We report results of an extensive worldwide observing campaign devoted to a very active dwarf nova star - IX Draconis. We investigated photometric behaviour of the system to derive its basic outburst properties and understand peculiarities of IX Draconis as well as other active cataclysmic variables, in particular dwarf novae of the ER UMa type. In order to measure fundamental parameters of the system, we carried out analyses of the light curve, O - C diagram, and power spectra. During over two months of observations, we detected two superoutbursts and several normal outbursts. The V magnitude of the star varied in the range 14.6-18.2 mag. Superoutbursts occur regularly with the supercycle length (Psc) of 58.5 ± 0.5 d. When analysing data over the past 20 years, we found that Psc is increasing at a rate of dot{P} = 1.8 × 10^{-3}. Normal outbursts appear to be irregular, with typical occurrence times in the range 3.1-4.1 d. We detected a double-peaked structure of superhumps during superoutburst, with the secondary maximum becoming dominant near the end of the superoutburst. The mean superhump period observed during superoutbursts is Psh = 0.066982(36) d (96.45 ± 0.05 min), which is constant over the last two decades of observations. Based on the power spectrum analysis, the evaluation of the orbital period was problematic. We found two possible values: the first one, 0.066 41(3) d (95.63 ± 0.04 min), which is in agreement with previous studies and our O - C analysis [0.06646(2) d, 95.70 ± 0.03 min], and the second one, 0.06482(3) d (93.34 ± 0.04 min), which is less likely. The evolutionary status of the object depends dramatically on the choice between these two values. A spectroscopic determination of the orbital period is needed. We updated available information on ER UMa-type stars and present a new set of their basic statistics. Thereby, we provide evidence that this class of stars is not uniform.

Otulakowska-Hypka, M.; Olech, A.; de Miguel, E.; Rutkowski, A.; Koff, R.; B?kowska, K.

2013-02-01

168

Sobrepeso e prevalência de cárie utilizando-se leite formulado - estudos em ratos Overweight and caries prevalence using formulated milk - rats study  

Microsoft Academic Search

Key-words Verificar a influência de uma dieta com leite formulado, leite formulado acrescido de 20% de sacarose e dieta controle, na prevalência de cárie nos molares de 36 ratos (Rattus norvegicus albinus wistar). Os animais, de ambos os sexos, com 23 dias de vida, foram divididos em três grupos, que ingeriram, durante 60 dias, as seguintes dietas: grupo A, leite

Renata Patrícia de Freitas Soares; Geraldo Bosco; Lindoso Couto; Márcia Maria; Vendenciano Barbosa Vasconcelos; Kátia Virgínia; Guerra Botelho; Freitas Soares; Rua Manoel Salvador

169

Efeito analgésico de longa duração da dipirona sobre a hiperalgesia persistente induzida pela constrição do nervo ciático em ratos: participação do óxido nítrico  

Microsoft Academic Search

O efeito analgésico de longa duração da dipirona foi avaliado em um modelo de dor neuropática assim como a participação da via óxido nítrico-GMPc neste mecanismo analgésico. Uma única administração intraplantar de dipirona (80 µg), no 14º dia após a instalação da hiperalgesia neuropática induzida pela constrição do nervo ciático exerceu um efeito analgésico, significativo e de longa duração. A

Fábio José Reis; Noeli Pereira Rocha

2006-01-01

170

Avaliação da pressão arterial de crianças e adolescentes aten- didos em Clínica Odontopediátrica Evaluation of the blood pressure of children and adolescents at- tending at the Odontopediatric Clinic  

Microsoft Academic Search

Key-words A hipertensão arterial sistêmica é uma doença que se mantém silenciosa, sem manifestação de qualquer sinal ou sintoma, antes de provocar sérios danos a órgãos nobres como coração, rins e cérebro. Para sua detecção precoce é necessária aferição periódica das pressões arteriais sistólica e diastólica desde os primórdios da infância. Sem dúvida, porém, em situações que gerem tensão ou

Cristiana Abrantes; Fonte Neves; Geraldo Bosco; Lindoso Couto; Kátia Virginia; Guerra Botelho; Márcia Maria Vendenciano Barbosa; Renata Patrícia de Freitas Soares; Jouse Bezerra Cavalcanti; Gineuda Maria do Prado Silva

171

The EM Earthquake Precursor  

NASA Astrophysics Data System (ADS)

Many attempts have been made to determine a sound forecasting method regarding earthquakes and warn the public in turn. Presently, the animal kingdom leads the precursor list alluding to a transmission related source. By applying the animal-based model to an electromagnetic (EM) wave model, various hypotheses were formed, but the most interesting one required the use of a magnetometer with a differing design and geometry. To date, numerous, high-end magnetometers have been in use in close proximity to fault zones for potential earthquake forecasting; however, something is still amiss. The problem still resides with what exactly is forecastable and the investigating direction of EM. After the 1989 Loma Prieta Earthquake, American earthquake investigators predetermined magnetometer use and a minimum earthquake magnitude necessary for EM detection. This action was set in motion, due to the extensive damage incurred and public outrage concerning earthquake forecasting; however, the magnetometers employed, grounded or buried, are completely subject to static and electric fields and have yet to correlate to an identifiable precursor. Secondly, there is neither a networked array for finding any epicentral locations, nor have there been any attempts to find even one. This methodology needs dismissal, because it is overly complicated, subject to continuous change, and provides no response time. As for the minimum magnitude threshold, which was set at M5, this is simply higher than what modern technological advances have gained. Detection can now be achieved at approximately M1, which greatly improves forecasting chances. A propagating precursor has now been detected in both the field and laboratory. Field antenna testing conducted outside the NE Texas town of Timpson in February, 2013, detected three strong EM sources along with numerous weaker signals. The antenna had mobility, and observations were noted for recurrence, duration, and frequency response. Next, two directional techniques were employed, resulting in three mapped, potential epicenters. The remaining, weaker signals presented similar directionality results to more epicentral locations. In addition, the directional results of the Timpson field tests lead to the design and construction of a third prototype antenna. In a laboratory setting, experiments were created to fail igneous rock types within a custom-designed Faraday Cage. An antenna emplaced within the cage detected EM emissions, which were both reproducible and distinct, and the laboratory results paralleled field results. With a viable system and continuous monitoring, a fracture cycle could be established and observed in real-time. Sequentially, field data would be reviewed quickly for assessment; thus, leading to a much improved earthquake forecasting capability. The EM precursor determined by this method may surpass all prior precursor claims, and the general public will finally receive long overdue forecasting.

Jones, K. B., II; Saxton, P. T.

2013-12-01

172

Spectroscopic Metallicity Determinations for W UMa-type Binary Stars  

NASA Astrophysics Data System (ADS)

This study is the first attempt to determine the metallicities of W UMa-type binary stars using spectroscopy. We analyzed about 4500 spectra collected at the David Dunlap Observatory. To circumvent problems caused by the extreme spectral line broadening and blending and by the relatively low quality of the data, all spectra were subject to the same broadening function (BF) processing to determine the combined line strength in the spectral window centered on the Mg I triplet between 5080 Å and 5285 Å. All individual integrated BFs were subsequently orbital-phase averaged to derive a single line-strength indicator for each star. The star sample was limited to 90 W UMa-type (EW) binaries with the strict phase-constancy of colors and without spectral contamination by spectroscopic companions. The best defined results were obtained for an F-type sub-sample (0.32 < (B - V)0 < 0.62) of 52 binaries for which integrated BF strengths could be interpolated in the model atmosphere predictions. The logarithmic relative metallicities, [M/H], for the F-type sub-sample indicate metal abundances roughly similar to the solar metallicity, but with a large scatter which is partly due to combined random and systematic errors. Because of the occurrence of a systematic color trend resulting from inherent limitations in our approach, we were forced to set the absolute scale of metallicities to correspond to that derived from the m 1 index of the Strömgren uvby photometry for 24 binaries of the F-type sub-sample. The trend-adjusted metallicities [M/H]1 are distributed within -0.65 < [M/H]1 < +0.50, with the spread reflecting genuine metallicity differences between stars. One half of the F-sub-sample binaries have [M/H]1 within -0.37 < [M/H]1 < +0.10, a median of -0.04 and a mean of -0.10, with a tail toward low metallicities, and a possible bias against very high metallicities. A parallel study of kinematic data, utilizing the most reliable and recently obtained proper motion and radial velocity data for 78 binaries of the full sample, shows that the F-type sub-sample binaries (44 stars with both velocities and metallicity determinations) have similar kinematic properties to solar-neighborhood, thin-disk dwarfs with space velocity component dispersions: ?U = 33 km s-1, ?V = 23 km s-1 and ?W = 14 km s-1. FU Dra with a large spatial velocity, V tot = 197 km s-1 and [M/H]1 = -0.6 ± 0.2, appears to be the only thick-disk object in the F-type sub-sample. The kinematic data indicate that the F-type EW binaries are typical, thin-disk population stars with ages about 3-5.5 Gyr. The F-type binaries that appear to be older than the rest tend to have systematically smaller mass ratios than most of the EW binaries of the same period. Based on observations obtained at the David Dunlap Observatory, University of Toronto.

Rucinski, Slavek M.; Pribulla, Theodor; Budaj, Ján

2013-09-01

173

Perda de massa em ventos empoeirados de estrelas supergigantes  

NASA Astrophysics Data System (ADS)

Em praticamente todas as regiões do diagrama HR, as estrelas apresentam evidências observacionais de perda de massa. Na literatura, pode-se encontrar trabalhos que tratam tanto do diagnóstico da perda de massa como da construção de modelos que visam explicá-la. O amortecimento de ondas Alfvén tem sido utilizado como mecanismo de aceleração de ventos homogêneos. Entretanto, sabe-se que os envelopes de estrelas frias contêm grãos sólidos e moléculas. Com o intuito de estudar a interação entre as ondas Alfvén e a poeira e a sua conseqüência na aceleração do vento estelar, Falceta-Gonçalves & Jatenco-Pereira (2002) desenvolveram um modelo de perda de massa para estrelas supergigantes. Neste trabalho, apresentamos um estudo do modelo acima proposto para avaliar a dependência da taxa de perda de massa com alguns parâmetros iniciais como, por exemplo, a densidade r0, o campo magnético B0, o comprimento de amortecimento da onda L0, seu fluxo f0, entre outros. Sendo assim, aumentando f0 de 10% a partir de valores de referência, vimos que aumenta consideravelmente, enquanto que um aumento de mesmo valor em r0, B0 e L0 acarreta uma diminuição em .

Vidotto, A. A.; Jatenco-Pereira, V.

2003-08-01

174

A distribuição de velocidades na linha de visada em galáxias barradas vistas de face  

NASA Astrophysics Data System (ADS)

Com o objetivo de realizar um estudo cinemático da componente vertical de barras em galáxias, obtivemos espectros de fenda longa de alta razão S/N ao longo dos eixos maior e menor de 14 galáxias barradas vistas de face, nos telescópios de 1.52m do ESO em La Silla, Chile, e de 2.3m do Steward Observatory em Kitt Peak, Arizona. Estes dados nos permitiram determinar a distribuição de velocidades das estrelas ao longo do eixo vertical das barras e discos destes sistemas, tanto no centro como em pontos que distam cerca de 5 e 20 segundos de arco do núcleo, correspondendo a distâncias de cerca de 0.7 e 2.8 kpc, respectivamente. Desta forma, a variação radial da distribuição de velocidades também pôde ser avaliada. Este tipo de análise tem raros exemplos na literatura por ser caro em termos de tempo de telescópio. Entretanto, é de fácil justificativa, considerando que traz novas informações que podem ser utilizadas para aperfeiçoar modelos teóricos acerca da formação e evolução de galáxias. Um algoritmo por nós desenvolvido foi utilizado para obter as distribuições de velocidades como Gaussianas generalizadas (polinômios de Gauss-Hermite), o que traz um ingrediente a mais neste tipo de estudo que, tradicionalmente, se utiliza de Gaussianas puras, uma hipótese nem sempre razoável. Apresentaremos os resultados deste trabalho, que incluem um diagnóstico para a identificação de barras recém formadas, e testes para o modelo isotérmico de discos. Mostraremos que: (i) a escolha das estrelas padrão em velocidade, e dos parâmetros da Gaussiana, deve ser muito bem justificada já que tem influência significativa nos resultados; (ii) muitas galáxias apresentam uma depressão na dispersão de velocidades na região central, que pode estar associada a um disco interno; e (iii) a dispersão de velocidades é constante ao longo da barra, nos eixos maior e menor, mas cai substancialmente quando se passa da barra para o disco.

Gadotti, D. A.; de Souza, R. E.

2003-08-01

175

V Seminário de Pesquisa em Turismo do MERCOSUL (SeminTUR) Turismo: Inovações da Pesquisa na América Latina Universidade de Caxias do Sul, RS, Brasil, 27 e 28 de Junho de 2008 Lazer, turismo e questões do patrimônio ambiental em áreas naturais: estudo de comparativo  

Microsoft Academic Search

Resumo Este trabalho tem o objetivo de fazer uma analise da importância das questões ambientais, vinculadas ao lazer e ao turismo sustentável em ambientes naturais no município de Pindamonhangaba, caracterizando a natureza destas atividades, verificando seus impactos e identificando possíveis ações planejadas que possam levar a um manejo equilibrado nestas áreas. Tendo como estudo de caso estas áreas naturais, o

Edésio da Silva Santos

176

A escolarização do corpo infantil: uma compreensão do discurso pedagógico a partir do século XVIII  

Microsoft Academic Search

RESUMO Dentre as possíveis concepções de corpo presentes na história da filosofia que influenciaram o pensamento educacional, o texto que se apresenta, centra esforços para discutir o momento em que o corpo passa a ser perce- bido em seus aspectos científico-biológico e psicológico, ao mesmo tempo em que ocorre o surgimento do processo de escolarização da infância e a incorporação

Marynelma Camargo Garanhani; Vera Luiza Moro

177

Why is the drug praziquantel effective in the treatment of parasitic flatworms? Praziquantel (PZQ) is the drug most commonly used in humans and livestock to  

E-print Network

such questions regarding cell differentiation in humans such as stem cell development and tissue regeneration. My addressing the agricultural sources of diseases such as cysticercosis, the infection of the brain and CNS in the manipulation of cell signaling pathways in studies regarding the differentiation of anterior and posterior axes

Minnesota, University of

178

Superoutbursts of selected new SU UMa-type and WZ Sge-type stars  

NASA Astrophysics Data System (ADS)

We present the results of our observations of selected new SU UMa-type and WZ Sge-type stars, which underwent their super-outbursts during the years 2007-2009. Photometric observations of SU UMa-type stars V632 Cyg, OT J080714.2+113812 and two WZ Sge-type stars V466 And and Nova Triangulum 2008 were carried out with the telescopes of the Crimean Laboratory of the SAI and StarA LesnA Observatory of the Astronomical Institute of the SAS. Photometric behaviour of SU UMa-type and WZ Sge-type stars during their superoutbursts is discussed.

Katysheva, N.; Chochol, D.; Shugarov, S.

2010-11-01

179

Identified EM Earthquake Precursors  

NASA Astrophysics Data System (ADS)

Many attempts have been made to determine a sound forecasting method regarding earthquakes and warn the public in turn. Presently, the animal kingdom leads the precursor list alluding to a transmission related source. By applying the animal-based model to an electromagnetic (EM) wave model, various hypotheses were formed, but the most interesting one required the use of a magnetometer with a differing design and geometry. To date, numerous, high-end magnetometers have been in use in close proximity to fault zones for potential earthquake forecasting; however, something is still amiss. The problem still resides with what exactly is forecastable and the investigating direction of EM. After a number of custom rock experiments, two hypotheses were formed which could answer the EM wave model. The first hypothesis concerned a sufficient and continuous electron movement either by surface or penetrative flow, and the second regarded a novel approach to radio transmission. Electron flow along fracture surfaces was determined to be inadequate in creating strong EM fields, because rock has a very high electrical resistance making it a high quality insulator. Penetrative flow could not be corroborated as well, because it was discovered that rock was absorbing and confining electrons to a very thin skin depth. Radio wave transmission and detection worked with every single test administered. This hypothesis was reviewed for propagating, long-wave generation with sufficient amplitude, and the capability of penetrating solid rock. Additionally, fracture spaces, either air or ion-filled, can facilitate this concept from great depths and allow for surficial detection. A few propagating precursor signals have been detected in the field occurring with associated phases using custom-built loop antennae. Field testing was conducted in Southern California from 2006-2011, and outside the NE Texas town of Timpson in February, 2013. The antennae have mobility and observations were noted for recurrence, duration, and frequency response. At the Southern California field sites, one loop antenna was positioned for omni-directional reception and also detected a strong First Schumann Resonance; however, additional Schumann Resonances were absent. At the Timpson, TX field sites, loop antennae were positioned for directional reception, due to earthquake-induced, hydraulic fracturing activity currently conducted by the oil and gas industry. Two strong signals, one moderately strong signal, and approximately 6-8 weaker signals were detected in the immediate vicinity. The three stronger signals were mapped by a biangulation technique, followed by a triangulation technique for confirmation. This was the first antenna mapping technique ever performed for determining possible earthquake epicenters. Six and a half months later, Timpson experienced two M4 (M4.1 and M4.3) earthquakes on September 2, 2013 followed by a M2.4 earthquake three days later, all occurring at a depth of five kilometers. The Timpson earthquake activity now has a cyclical rate and a forecast was given to the proper authorities. As a result, the Southern California and Timpson, TX field results led to an improved design and construction of a third prototype antenna. With a loop antenna array, a viable communication system, and continuous monitoring, a full fracture cycle can be established and observed in real-time. In addition, field data could be reviewed quickly for assessment and lead to a much more improved earthquake forecasting capability. The EM precursors determined by this method appear to surpass all prior precursor claims, and the general public will finally receive long overdue forecasting.

Jones, Kenneth, II; Saxton, Patrick

2014-05-01

180

F589 -QUINTA LISTA DE EXERCICIOS 1. Mostre, para um atomo de Thompson, que um eletron que esta em movimento em  

E-print Network

F589 - QUINTA LISTA DE EXERC´ICIOS 1. Mostre, para um ´atomo de Thompson, que um el´etron que est part´icula de 5.30 MeV ´e espalhada por um ^angulo de 60 graus ao passar por uma fina folha met. Mostre que a frequ^encia de rota¸c~ao de um el´etron em um ´atomo no modelo de hidrog^enio de Bohr ´e

de Aguiar, Marcus A. M.

181

O que aconteceu uma fraco de segundo depois do Big Bang  

E-print Network

O que aconteceu uma fracção de segundo depois do Big Bang deixou de ser só teoria Primeiros sinais segundo Cientistas apanharam vestí- gios do que passou uma fracção de segundo após o Big Bang. Colegas vão baptiza- da de Big Bang. Resultados da experiên- cia BICEP2, no Pólo Sul, prometem arru- mar o assunto. Os

Instituto de Sistemas e Robotica

182

Curious Variables Experiment (CURVE). CCD photometry of active dwarf nova DI UMa  

Microsoft Academic Search

We report an analysis of photometric behaviour of DI UMa, an extremely active\\u000adwarf nova. The observational campaign (completed in 2007) covers five\\u000asuperoutbursts and four normal outbursts. We examined principal parameters of\\u000athe system to understand peculiarities of DI UMa, and other active cataclysmic\\u000avariables. Based on precise photometric measurements, temporal light curve\\u000abehaviour, O-C analysis, and power spectrum

A. Rutkowski; A. Olech; M. Wi?niewski; P. Pietrukowicz; J. Pala; R. Poleski

2008-01-01

183

UMA WorldCat Sample Search 1 of 12| P a g e  

E-print Network

terms into the provided search box. Hit the enter key or click on the "search" button to run your queryUMA WorldCat Sample Search 1 of 12| P a g e A t t a c h m e n t 1 o f : T e a c h i n g E n g l i H u t t o n In this guide you will find: UMA WorldCat description Conducting a simple search Finding

Schweik, Charles M.

184

Evolução temporal da explosão solar de 06 de junho de 2000 apresentando estruturas finas em rádio freqüências  

NASA Astrophysics Data System (ADS)

Em 06 de junho de 2000 (~15: 00-17: 00 UT), o Brazilian Solar Spectroscope (BSS) registrou uma explosão solar intensa no intervalo de freqüência de (1000-2000) MHz, com alta resolução temporal (100 ms) e espectral (5 MHz). A atividade solar relacionada a esta explosão associada à região ativa (AR) 9026 e classificada como X2.3 foi grande. O Ondrejov Observatory registrou rádio emissões até 4,5 GHz. O satélite SOHO registrou uma série de erupções solares, incluindo uma Ejeção de Massa Coronal (CME) tipo "full-halo" (~15: 54 UT). Explosões tipo II/IV também foram registradas. Na faixa de ondas decimétricas, este evento apresentou dois picos distintos (~15: 21 UT e ~16: 42 UT). O primeiro pico coincide com a explosão registrada em raios-X moles (GOES) e em raios-X duros (Yohkoh). Os espectros dinâmicos com alta resolução do BSS revelaram várias estruturas finas, principalmente emissões tipo "zebra" e "fibra", rádio pulsações, emissões tipo III e do único caso de emissões "zebra" harmônicas observado na faixa decimétrica. Neste trabalho, analisamos a evolução temporal e o comportamento global do evento de 06 de junho de 2000, com ênfase na identificação e associação da ocorrência de cada tipo de estrutura fina registrada em rádio com cada etapa da explosão. Resultados preliminares mostraram que, na fase pré-flare, as estruturas finas apresentaram taxa de deriva negativa (~ 70-190 MHz/s). As emissões tipo "zebra" concentram-se na fase de descida do primeiro pico impulsivo e na de subida do segundo pico. Enquanto que as emissões tipo "fibra" ocorrem em ambas fases, mas preferivelmente durante a fase de descida. Os resultados serão apresentados e discutidos.

Fernandes, F. C. R.; Sawant, H. S.; Cecatto, J. R.; Caracini, A. G.; Vats, H. O.; Karlický, M.; Meszarosova, H.

2003-08-01

185

A estabilidade dos PAHS em função da energia da radiação interestelar nas faixas UV e raios-X  

NASA Astrophysics Data System (ADS)

A nebulosa CRL 618, uma proto-nebulosa planetária cuja nuvem molecular espessa envolve uma estrela B0, contém uma grande quantidade de C2H2 e CH4. Estas moléculas são consideradas os tijolos da criação de grandes moléculas carbonadas como os Hidrocarbonetos Policíclicos Aromáticos (PAHs). Esta nebulosa, por estar exposta a intensos campos de UV e Raios-X, é uma região de fotodissociação molecular que propicia a formação de novas moléculas, confirmada pela presença de C4H2 e C6H6 (Benzeno), que é a unidade básica dos PAHs. Atribui-se a esta família de moléculas orgânicas duas propriedades fundamentais, a resistência para sobreviver ao campo de radiação UV interestelar e a geração das bandas de emissão não identificadas (UIR) observadas no infravermelho. No entanto, alguns autores questionam a resistência dos PAHs ao campo de radiação UV interestelar. Empregando a técnica de Espectrometria de Massas por Tempo de Vôo, no modo de coincidência fotoelétron-fotoíon, estudamos a ionização e fragmentação das seguintes moléculas: Benzeno, Benzeno deuterado, Naftaleno, Antraceno e Fenantreno. Utilizamos uma fonte de Hélio monocromática em 21,21 eV (584,5 Å) e a radiação Síncroton do Laboratório Nacional de Luz Síncroton (LNLS) em diferentes energias nas proximidades da borda do C 1s ( 290 eV). Comprovamos a estabilidade dos PAHs sob ação de UV (21,21 eV), onde eles apresentam um baixo nível de fotodissociação, produzindo fragmentos ionizados com rendimento total na ordem de 5 por cento em relação ao íon molecular pai. Entretanto, em altas energias, na faixa de Raios-X, a quebra destas moléculas torna-se mais intensa, com a produção de muitos fragmentos. Como uma das rotas de fragmentação do Naftaleno é [(C10H8) = > (C6H6+) + (C4H2) + (e-)], e como temos as evidências observacionais da existência do C4H2 e C6H6 na nebulosa CRL 618, sugerimos que este ambiente também possui o Naftaleno.

Pinotti, R.; Costa, R. K.; Boechat-Roberty, H. M.; Lago, A.; Souza, G. B.

2003-08-01

186

DISTÚRBIOS NUTRICIONAIS INDUZIDOS PELA ADUBAÇÃO DE FÓSFORO E FERRO EM PLANTAS JOVENS DE GRÁPIA (Apuleia leiocarpa) NUTRITIONAL DISTURBANCE INDUCED BY PHOSPHORUS AND IRON FERTILIZATION ON YOUNG PLANTS OF GRÁPIA (Apuleia leiocarpa)  

Microsoft Academic Search

A grápia (Apuleia leiocarpa Vog. Macbride) é uma espécie florestal nativa de grande interesse madeireiro, encontrando-se, atualmente, bastante dizimada. Em trabalhos anteriores, foi observado que as folhas novas de plantas jovens de grápia apresentaram sintomas visuais indicativos de deficiência de Fe na presença de doses crescentes de P. O presente trabalho teve como objetivo caracterizar os efeitos da interação da

Evandro Luiz Missio; Fernando Teixeira Nicoloso

2005-01-01

187

College of Engineering EM Engineering Mechanics  

E-print Network

College of Engineering EM Engineering Mechanics KEY: # = new course * = course changed = course or concur: MA 213. EM 302 MECHANICS OF DEFORMABLE SOLIDS. (3 of Engineering or consent of chairperson, and EM 221; prereq or concur: MA 214. EM 313 DYNAMICS. (3

MacAdam, Keith

188

Investimento ambiental em indústrias sujas e intensivas em recursos naturais e energia  

Microsoft Academic Search

O crescimento industrial brasileiro, a partir do final dos anos setenta, ocorreu com o aumento da participação de indústrias intensivas em recursos naturais, em detrimento da participação de indústrias intensivas em trabalho e dos setores intensivos em atividades tecnológicas mais complexas. Essas transformações, tornando o setor de bens intermediários dominante na estrutura industrial, implicaram em consideráveis mudanças tanto de ordem

Frederico Cavadas Barcellos; Jurandir Carlos de Oliveira; Paulo Gonzaga Mibielli de Carvalho

2009-01-01

189

CRÍTICA LITERÁRIA FEMINIST A ENTRE ERÓTICA E ENGAJAMENTO POLÍTICO : UMA QUESTÃO POLÊMICA  

Microsoft Academic Search

Resumo:A partir de exame bibliográfico, perspectiva interdisciplinar e observação empírica, este estudo pretende, dentro do contexto latino-americano (Brasil e América Hispânica) das ditaduras militares, discutir algumas das possíveis relações entre temas polêmicos como o feminismo, crítica literária feminista e engajamento político, debatidos em certos setores da mídia e refletidos em obras literárias. Textos da ar gentina Marta Pynch, da costaricense

Vera Lúcia Dietzel

190

Estudo espectral em raios-X duros de fontes do tipo Z com o HEXTE/RXTE  

NASA Astrophysics Data System (ADS)

Apresentam-se os resultados de um estudo espectral em raios-X de fontes do tipo Z. As fontes do tipo Z são binárias de raios-X de baixa massa (BXBM) com campo magnético intermediário (B~109G). Esta classe de fontes é composta por apenas 6 fontes Galácticas (a saber: ScoX-1, 9, 7, CygX-2, 5 e 0). A nossa análise se concentra na faixa de raios-X duros (E ~ 20keV), até cerca de 200keV, faixa ótima de operação do telescópio "High Energy X-ray Timing Experiment" (HEXTE), um dos três telescópios de raios-X à bordo do Rossi X-ray Timing Explorer (RXTE). Nossa motivação para tal estudo, uma busca de caudas em raios-X duros em fontes do tipo Z, foi o pouco conhecimento sobre a emissão nesta faixa de energia das referidas fontes quando comparadas, por exemplo, as fontes do tipo atoll (também BXBM). Apresentam-se a análise/redução de dados e explicita-se a maneira como o HEXTE mede o ru1do de fundo. Especial atenção é direcionada a este item devido a localização das fontes do tipo Z e também ao problema de contaminação por fontes próximas. Com exceção de ScoX-1, nenhuma cauda em raios-X duros foi encontrada para as outras fontes, a despeito de resultados de detecção dessas caudas em algumas fontes pelo satélite BeppoSAX. As interpretações deste resultado serão apresentadas. Do ponto de vista deste estudo, nós deduzimos que a produção de caudas de raios-X duros em fontes do tipo Z é um processo disparado quando, pelo menos, uma condição é satisfeita: o brilho da componente térmica do espectro precisa estar acima de um certo valor limiar de ~4´1036ergs-1.

D'Amico, F.; Heindl, W. A.; Rothschild, R. E.

2003-08-01

191

Turismo Náutico em Angra dos Reis – RJ : a sustentabilidade em questão.  

E-print Network

??Dissertação (mestrado)—Universidade de Brasília, Centro de Desenvolvimento Sustentável, 2011. O turismo está em franca expansão e se desenvolvendo a taxas bastante significativas no Brasil. Em… (more)

Medeiros, Márcio Bastos

2011-01-01

192

77 FR 4225 - Oral Dosage Form New Animal Drugs; Milbemycin Oxime, Lufenuron, and Praziquantel  

Federal Register 2010, 2011, 2012, 2013

...control of various internal parasites in dogs. DATES: This rule is effective January...whipworm, and adult tapeworm infections in dogs and puppies 2 pounds of body weight or...Reserved] (d) Conditions of use--(1) Dogs--(i) Amount. 0.5 mg...

2012-01-27

193

77 FR 47511 - New Animal Drugs; Cephalexin; Fentanyl; Milbemycin Oxime and Praziquantel  

Federal Register 2010, 2011, 2012, 2013

...AND HUMAN SERVICES Food and Drug Administration 21 CFR Parts...FDA-2012-N-0002] New Animal Drugs; Cephalexin; Fentanyl; Milbemycin...New animal drug NADA/ANADA Sponsor product...CE \\1\\ Pharmaceuticals, Transdermal Solution. control of...

2012-08-09

194

21 CFR 520.1872 - Praziquantel, pyrantel pamoate, and febantel tablets.  

...tapeworms (Dipylidium caninum, Taenia pisiformis, Echinococcus granulosus ); hookworms (Ancylostoma caninum...and for the removal and control of tapeworm Echinococcus multilocularis in dogs. (iii) Limitations....

2014-04-01

195

21 CFR 520.1872 - Praziquantel, pyrantel pamoate, and febantel tablets.  

Code of Federal Regulations, 2010 CFR

...tapeworms (Dipylidium caninum, Taenia pisiformis, Echinococcus granulosus ); hookworms (Ancylostoma caninum...and for the removal and control of tapeworm Echinococcus multilocularis in dogs. (iii) Limitations...

2010-04-01

196

21 CFR 520.1447 - Milbemycin oxime, lufenuron, and praziquantel tablets.  

...Ancylostoma caninum ), adult whipworm (Trichuris vulpis ), and adult tapeworm (Taenia pisiformis, Echinococcus multilocularis, and E. granulosus ) infections in dogs and puppies 2 pounds of body weight or greater and 6 weeks...

2014-04-01

197

21 CFR 520.1447 - Milbemycin oxime, lufenuron, and praziquantel tablets.  

Code of Federal Regulations, 2012 CFR

...Ancylostoma caninum ), adult whipworm (Trichuris vulpis ), and adult tapeworm (Taenia pisiformis, Echinococcus multilocularis, and E. granulosus ) infections in dogs and puppies 2 pounds of body weight or greater and 6 weeks...

2012-04-01

198

21 CFR 520.1872 - Praziquantel, pyrantel pamoate, and febantel tablets.  

Code of Federal Regulations, 2012 CFR

...tapeworms (Dipylidium caninum, Taenia pisiformis, Echinococcus granulosus ); hookworms (Ancylostoma caninum...and for the removal and control of tapeworm Echinococcus multilocularis in dogs. (iii) Limitations...

2012-04-01

199

21 CFR 520.1872 - Praziquantel, pyrantel pamoate, and febantel tablets.  

Code of Federal Regulations, 2013 CFR

...tapeworms (Dipylidium caninum, Taenia pisiformis, Echinococcus granulosus ); hookworms (Ancylostoma caninum...and for the removal and control of tapeworm Echinococcus multilocularis in dogs. (iii) Limitations...

2013-04-01

200

21 CFR 520.1872 - Praziquantel, pyrantel pamoate, and febantel tablets.  

Code of Federal Regulations, 2011 CFR

...tapeworms (Dipylidium caninum, Taenia pisiformis, Echinococcus granulosus ); hookworms (Ancylostoma caninum...and for the removal and control of tapeworm Echinococcus multilocularis in dogs. (iii) Limitations...

2011-04-01

201

21 CFR 520.1447 - Milbemycin oxime, lufenuron, and praziquantel tablets.  

Code of Federal Regulations, 2013 CFR

...Ancylostoma caninum ), adult whipworm (Trichuris vulpis ), and adult tapeworm (Taenia pisiformis, Echinococcus multilocularis, and E. granulosus ) infections in dogs and puppies 2 pounds of body weight or greater and 6 weeks...

2013-04-01

202

Avaliação do índice de biofilme bacteriano em professores - um estudo piloto Evaluation of the index of bacterial plate of the tea- chers - a pilot study  

Microsoft Academic Search

Key-words O objetivo desse trabalho foi realizar o estudo piloto para investigar o perfil de higiene bucal dos professores de uma escola pública municipal em Aracaju\\/SE, onde seria desenvolvido posteriormente um programa educativo-preventivo. Avaliou-se a placa bacteriana de 09 (nove) docentes para que se fizesse a análise da situação do campo e para que as ações pudessem ser planejadas. Os

Promoção de Saúde

203

Self System in a Model of Cognition Uma Ramamurthy* and Stan Franklin**  

E-print Network

Self System in a Model of Cognition Uma Ramamurthy* and Stan Franklin** * St Jude Children@memphis.edu. Abstract. Philosophers, psychologists and neuroscientists have proposed various forms of a "self" in humans Theory (GWT) [1 - 3] suggests a mostly unconscious, many layered self-system. In this paper we consider

Memphis, University of

204

Maskless deposition of ZnO films Uma Choppali a*1  

E-print Network

enough to deposit a large variety of precursors and colloidal suspensions. It is a simple and convenient1 Maskless deposition of ZnO films Uma Choppali a*1 , Elias Kougianosb , Saraju P. Mohantyb Maskless Mesoscale Materials Deposition (M3 DTM ) is a new direct write technique, which is versatile

Mohanty, Saraju P.

205

Burning the EMS candle. EMS shifts and worker fatigue.  

PubMed

Has coffee become your best friend? Do you sleep only in your dreams? Is your bed merely an illusion? If so, you are not alone; sleep deprivation is a fact of life for many EMS personnel. Though widely accepted, isn't it time that we question the effects of those long days and nights? PMID:10116022

McCallion, R; Fazackerley, J

1991-10-01

206

Aquecimento alfvênico viscoso-resistivo em discos de acresção ao redor de estrelas T Tauri clássicas  

NASA Astrophysics Data System (ADS)

Com a crescente disponibilidade de dados observacionais sobre estrelas T Tauri, a busca por modelos mais precisos vem se tornando cada vez maior. Estes modelos devem explicar, entre outras coisas, o mecanismo dissipativo responsável pelo transporte de momento angular no disco de acresção que acredita-se, circunda estas estrelas. O mecanismo mais viável, do ponto de vista teórico, é uma instabilidade MHD conhecida como "instabilidade magnetorotacional ou Balbus-Hawley" (IBH). Esta instabilidade veio mostrar que o campo magnético desempenha um papel importante na evolução destes objetos mas requer, no entanto, um acoplamento mínimo entre o gás e o campo magnético no disco que não é atingido para os valores de temperatura obtidos do modelo padrão. Contudo, alguns mecanismos de aquecimento para o disco precisam ser examinados. Neste trabalho, propomos a dissipação de ondas Alfvén como uma fonte de aquecimento para o disco. Se o gás apresentar uma condutividade elétrica finita e viscosidade, teremos um tipo de amortecimento para as ondas denominado amortecimento viscoso-resistivo que será aqui considerado. Este mecanismo é aplicado ao modelo de disco em camadas. Calculam-se as taxas de aquecimento Alfvênico, a temperatura efetiva do disco bem como as taxas de ionização decorrentes deste aquecimento e do aquecimento gerado pela absorção de raios cósmicos. Comparações com os dados observacionais de Kitamura et. al. (2001) são efetuadas, ressaltando-se os pontos comuns entre suas observações e nossos dados teóricos.

Santana, W. M.; Vasconcelos, M. J.

2003-08-01

207

Violência sexual contra crianças e adolescentes : uma análise de discurso crítica no âmbito terapêutico.  

E-print Network

??Tese (doutorado)—Universidade de Brasília, Instituto de Letras, Departamento de Linguística, Português e Línguas Clássicas, Programa de Pós-Graduação em Linguística, 2014. O objetivo desta pesquisa é… (more)

Silva, Sandro Xavier da

2014-01-01

208

Programa de Ps-Graduao em Economia  

E-print Network

1 Programa de Pós-Graduação em Economia PPG-ECO Universidade de Brasília UnB UNIVERSIDADE DE BRASÍLIA PROGRAMA DE P�S-GRADUA��O EM ECONOMIA EDITAL No. 1/2014 SELE��O DE CANDIDATOS �S VAGAS DO PROGRAMA DE P�S-GRADUA��O EM ECONOMIA PARA O CURSO DE MESTRADO PROFISSIONAL EM ECONOMIA ­ ÁREA DE CONCENTRA��O

Maier, Rudolf Richard

209

WRF-EMS Aviation Products  

NSDL National Science Digital Library

This lesson illustrates how numerical guidance from the Weather Research and Forecasting Model - Environmental Modeling System (WRF-EMS) can be added to surface observations, satellite graphics, and conceptual models of important aviation phenomena, to produce TAFs. Specifically, the lesson describes how visibility, cloud ceilings, and the flight categories variables provide values for aviation forecasts in Africa.

Comet

2013-09-25

210

The European Mobile System (EMS)  

NASA Technical Reports Server (NTRS)

The European Space Agency is presently procuring an L band payload in order to promote a regional European L band system coping with the specific needs of the European market. The payload, and the two communications systems to be supported, are described below. The potential market for EMS in Europe is discussed.

Jongejans, A.; Rogard, R.; Mistretta, I.; Ananasso, F.

1993-01-01

211

Angus Robichaud's Reel G Em D A Bm D7  

E-print Network

Angus Robichaud's Reel 4 4 D G A D D G A D 3 3 G Em D A Bm D7 3 3 G Em D A D Animas Reel Bernie Waugh 4 4 3 3 G D G Bm Em C Am C D G D G Bm Em C Am D G The Arkansas Traveler 4 2 D G A D Em A 3D G A D Em G A D D G D A Bm Em A D G D A Em G A D #12;Asher Rodney Miller 4 4 D Em F#m G A D Em G A D A D1 2

Doyle, Peter

212

Angus Robichaud's Reel G Em D A Bm D7  

E-print Network

Angus Robichaud's Reel 4 4 D G A D D G A D 3 3 G Em D A Bm D7 3 3 G Em D A D Animas Reel Bernie Waugh 4 4 3 3 G D G Bm Em C Am C D G D G Bm Em C Am D G The Arkansas Traveler 4 2 D G A D Em A 3 D G A D Em G A D D G D A Bm Em A D G D A Em G A D #12; Asher Rodney Miller 4 4 D Em F#m G A D Em G A D A D 1

Doyle, Peter

213

Discovery of a W UMa type binary GSC 03553-00845  

NASA Astrophysics Data System (ADS)

When observing the transiting extrasolar planets, we discovered a new W UMa type binary GSC 03553-00845. Following observation was carried out using the 1 m telescope at Weihai Observatory of Shandong University. Complete BVR light curves were determined. Using the W-D program, we analyzed the light curves. Photometric solution reveals that GSC 03553-00845 is a W-subtype W UMa type binary with a mass ratio of q = 2.904, it is an overcontact binary system by a contact degree of f = 29.5% with a small temperature difference between the components (?T = 206 K) indicating a good thermal contact between the components. More observation of GSC 03553-00845 is needed in order to analyze the light curve variation and orbital period change.

Guo, Di-Fu; Li, Kai; Hu, Shao-Ming; Jiang, Yun-Guo; Gao, Dong-Yang; Chen, Xu

2014-09-01

214

ULTRACAM photometry of the eclipsing cataclysmic variables XZ Eri and DV UMa  

NASA Astrophysics Data System (ADS)

We present high-speed, three-colour photometry of the faint eclipsing cataclysmic variables XZ Eri and DV UMa. We determine the system parameters through two techniques: first, timings of the eclipse contact phases of the white dwarf and bright-spot using the derivative of the light curve; and secondly, a parametrized model of the eclipse fitted to the observed light curve by ?2 minimization. For both objects, we prefer the latter method, as it is less affected by photon noise and rapid flickering. For XZ Eri we obtain a mass ratio q= 0.1098 +/- 0.0017 and an orbital inclination . For DV UMa we derive figures of q= 0.1506 +/- 0.0009 and . The secondary star in XZ Eri has a very low mass Mr/Msolar= 0.0842 +/- 0.0024, placing it close to the upper limit on the mass of a brown dwarf.

Feline, W. J.; Dhillon, V. S.; Marsh, T. R.; Brinkworth, C. S.

2004-11-01

215

Uma equipa de investigadores portugueses pretende fazer o mapeamento 3D das Ilhas  

E-print Network

da Península Antártica. Na bagagem, leva um drone por Hugo Séneca m 50 anos, a temperatura média da cartografia de Marte, uma campanha de crowdfunding e um drone que promete acelerar a capacidade de mapeamento de um drone EBEE, da fabricante SenseFly, para o mapeamento 3D da península Antár- Os investigadores

Instituto de Sistemas e Robotica

216

Halema`uma`u Slug Degassing and Chamber Reverberation from Infrasound Pressure Records (Invited)  

NASA Astrophysics Data System (ADS)

Previous work has shown that the exsolution of gas from magma can efficiently produce infrasound at Kilauea Volcano, Hawaii. The interaction of unsteady gas flux with open conduits and cavities causes acoustic reverberations that enrich the observed sound field. An infrasound array ~7 km from Halema`uma`u vent has recorded nearly continuous infrasound since the March 19th, 2008 vent clearing burst, including numerous other degassing and episodic tremor events. Persistent harmonic tremor has accompanied all stages of activity, with a mean acoustic source power of ~7 kW at the vent. Infrasonic array records of the degassing bursts in the very long period (IVLP, 0.03-0.1 Hz) and long period (ILP, 0.1-1 Hz) frequency bands captured the pressure-time history of the shallow conduit system at Halema`uma`u. Seismic very long period (VLP) modeling suggests the bursts result from rising gas slugs (Chouet and Dawson, in press). Gas slug ascent and subsequent non-explosive surface degassing can also explain selected IVLP and ILP records. Depressurization at the onset of the IVLP is indicative of decompression within the shallow conduit and possible acoustic activation of the slug. As the slug ascends, the slug nose accelerates in the upper portion of the conduit and displaces the fluid above it, causing a compressional acoustic signal. Time-synchronized video (courtesy of M. Patrick, HVO) show that the positive pressure peak of the IVLP signal corresponds to the arrival of the slug front pressure signal from the magma surface to the top of the Halema`uma`u vent. Acoustic excitation of the Halema`uma`u cavity then follows, with the ILP representing the resonance and reverberation of the cavity itself. Using simplified models and the acoustic pressure records, we derive parameters for the rising slug, gas-filled cavity, and conduit that are consistent with seismic and numerical modeling of gas slug ascent and surface degassing at Kilauea.

Fee, D.; Garces, M.

2009-12-01

217

Reproducing superhumps and gamma-shifts of SU UMa stars with SPH simulations  

Microsoft Academic Search

We performed two-dimensional smoothed particle hydrodynamics (SPH) simulations of SU UMa stars during superoutburst using the parameters of four systems with well-known orbital and superhump periods. We establish that only in systems with mass ratios q=M_1\\/M_2>~4 do eccentric accretion discs evolve. This is in excellent agreement with theory. The simulated light curves show superhumps with the same period and amplitude

S. Kunze; R. Speith; H. Riffert

1997-01-01

218

Exercicios extra propostos (em actualizac~ao ao longo do curso...) Grau de dificuldade: muito facil; facil, etc.  

E-print Network

(p)Dvg(p) (c) Se g n~ao se anular numa vizinhan¸ca de p ent~ao Dv(f/g)(p) = Dvf(p)g(p) - Dvg(p)f(p) [g(p)]2 (d~ao limitadas numa vizinhan¸ca de um ponto p RN . Prove que f ´e cont´inua em p. 10. () Seja g : Rk R uma fun a equa¸c~ao x2 + y2 + z2 = (x + y + z) onde C1 (R) ´e tal que (0) = 0 e (0) = 1. Prove que numa

Baia, Margarida

219

Observação do abrilhantamento de limbo solar e de estruturas filamentares em 48 ghz utilizando a técnica de regularização adaptativa  

NASA Astrophysics Data System (ADS)

O radiotelescópio do Itapetinga tem sido utilizado em campanhas de observações de explosões solares gerando um grande número de mapas diários em 48 GHz como sub-produto destas observações. A resolução espacial do telescópio de 14m do Itapetinga nesta freqüência é de aproximadamente dois minutos de arco. Estruturas de interesse para análise da atmosfera solar quiescente tais como os filamentos e o anel de abrilhantamento do limbo são de dimensão angular moderada da ordem ou ligeiramente menores que a resolução do telescópio. É conhecido que a convolução da função de espalhamento do telescópio, PSF (padrão de ganho do feixe) borra as estruturas de dimensão angular abaixo do HPBW (largura a meia potência do feixe) e portanto é comum a busca por técnicas de restauração que eliminem pelo menos em parte este borramento. Estudamos a restauração destas radioimagens usando a técnica de regularização adaptativa e os resultados ressaltam estas estruturas espaciais de pequeno contraste. O algoritmo da regularização adaptativa faz uso de k imagens, chamadas protótipos, obtidas através da variação de parâmetros de um filtro de regularização. Para controle da qualidade da restauração utilizamos uma imagem de alta resolução espacial obtida na linha H-a e a PSF do Itapetinga para borrá-la. Pequenos desvios, entre a PSF utilizada para o borramento e a PSF utilizada na restauração, produziram alguns desvios notáveis na imagem restaurada porém a adição de ruído nas simulações de restauração foram mais influentes no cálculo da rugosidade da imagem e portanto mais limitante para a restauração. Apresentamos como nosso primeiro resultado uma imagem em 48 GHz com a presença clara do abrilhantamento de limbo que não estava evidente na imagem original e traços de estruturas filamentares, porém ainda sem grande evidência.

Machado, W. R. S.; Mascarenhas, N.; Costa, J. E. R.; Silva, A. V. R.

2003-08-01

220

DEPARTAMENTO DE ECONOMIA MESTRADO EM ECONOMIA  

E-print Network

DEPARTAMENTO DE ECONOMIA MESTRADO EM ECONOMIA EDITAL DE CONVOCA��O ­ 2014 Estão abertas as inscrições para o Mestrado em Economia da PUC-Rio, a iniciar-se em janeiro de 2014. Para candidatos residentes no Brasil: A admissão é feita através do Exame Nacional de Economia, organizado pela ANPEC

221

DEPARTAMENTO DE ECONOMIA DOUTORADO EM ECONOMIA  

E-print Network

DEPARTAMENTO DE ECONOMIA DOUTORADO EM ECONOMIA EDITAL DE CONVOCA��O ­ 2014 Estão abertas as inscrições para o Doutorado em Economia da PUC-Rio, a iniciar-se em janeiro de 2014. O período de inscrições ]: Departamento de Economia [ref.: Candidatura ao Doutorado] Pontifícia Universidade Católica do Rio de Janeiro

222

AVALIAÇÃO DA EFICIÊNCIA DAS COOPERATIVAS AGROINDUSTRIAIS PARANAENSES: UMA ABORDAGEM ECONÔMICA E SOCIAL UTILIZANDO DEA  

Microsoft Academic Search

É perceptível a grande preocupação em avaliar a eficiência das organizações cooperativas de modo a estabelecer indicadores e padrões de análise, porém ainda não é possível encontrar na literatura quais são as práticas de referência para cooperativas agroindustriais capazes de possibilitar maior eficiência considerando a dimensão econômica e social destas instituições. Notou-se, diante da realização deste estudo, que alguns indicadores

Julines Bega Peixe; Roberto Max Protil

2008-01-01

223

AN?LISE DA INSER??O DOS TEMAS DE HUMANIDADES E ?TICA, COM METODOLOGIA DE APRENDIZAGEM BASEADA EM PROBLEMAS, EM CURRICULO M?DICO INTEGRADO EM ESCOLA P?BLICA NO DISTRITO FEDERAL, BRASIL  

PubMed Central

Objetivo Realizar uma análise da inserção da ética e humanidades no currículo do Curso de Medicina da Escola Superior em Ciências da Saúde - ESCS, escola pública do Distrito Federal, Brasil, de forma a contribuir com o processo de gestão curricular. Metodologia O Estudo é de coorte e documental. Foram pesquisados 37 termos relacionados à ética e 36 referentes à humanização nos objetivos educacionais e conteúdo dos módulos temáticos, habilidades e atitudes e interação ensino-serviço-comunidade, de 1a a 4a série e no programa do internato no currículo (ano 2006) e no projeto pedagógico do Curso de Medicina (2001). Resultados Maior inserção da humanização, ética e bioética na 1a e 2a série, quando comparado à inserção na 3a e 4a série e no internato, (IC95%-?=0,034, pvalue=0,007). Unidade de habilidades e atitudes: freqüência das 3 temáticas no currículo da 1a a 4a séries (IC95%-?=0,026, pvalue=0,013). Quando comparada a inserção entre o internato e as quatro primeiras séries, observa-se que nestas a inserção da temática humanização é superior (IC95%-?=0,042, pvalue=0,029). Conclusão O currículo desenvolvido no ano de 2006 na ESCS apresentou correlação com o projeto pedagógico do curso e contemplou a temática de forma abrangente, em todas as séries e internato. PMID:20396594

Novaes, Maria Rita Carvalho Garbi; Novaes, Luiz Carlos Garcez; Guilhem, Dirce; Lolas, Fernando; Silveira, Carla; Guiotti, Murilo

2009-01-01

224

Origin of W UMa-type contact binaries - age and orbital evolution  

NASA Astrophysics Data System (ADS)

Recently, our understanding of the origin of W UMa-type contact binaries has become clearer. Initial masses of their components were successfully estimated by Y?ld?z and Do?an using a new method mainly based on observational properties of overluminous secondary components. In this paper, we continue to discuss the results and make computations for age and orbital evolution of these binaries. It is shown that the secondary mass, according to its luminosity, also successfully predicts the observed radius. While the current mass of the primary component is determined by initial masses, the current secondary mass is also a function of initial angular momentum. We develop methods to compute the age of A- and W-subtype W UMa-type contact binaries in terms of initial masses and mass according to the luminosity of the secondaries. Comparisons of our results with the mean ages from kinematic properties of these binaries and data pertaining to contact binaries in open and globular clusters have increased our confidence on this method. The mean ages of both A- and W-subtype contact binaries are found as 4.4 and 4.6 Gyr, respectively. From kinematic studies, these ages are given as 4.5 and 4.4 Gyr, respectively. We also compute orbital properties of A-subtype contact binaries at the time of the first overflow. Initial angular momentum of these binaries is computed by comparing them with the well-known detached binaries. The angular momentum loss rate derived in the present study for the detached phase is in very good agreement with the semi-empirical rates available in the literature. In addition to the limitations on the initial masses of W UMa-type contact binaries, it is shown that the initial period of these binaries is less than about 4.45 d.

Y?ld?z, M.

2014-01-01

225

Lietuvos teritorijos žem?s plutos deformacij? ir seismotektoninio potencialo ryšys  

NASA Astrophysics Data System (ADS)

Lietuvoje yra statini?, kelian?i? ekologinio pavojaus gr?sm? (Ignalinos atomin? elektrin?, Mažeiki? naftos perdirbimo ?mon?, chemijos gamyklos Jonavoje bei K?dainiuose ir pan.). Seisminiai ?vykiai gali sutrikdyti ši? ?moni? veikl? ir net lemti didel? pavoj? aplinkai, t. y. gali b?ti sukelta didel? aplinkos tarša chemin?mis bei radioaktyviosiomis medžiagomis. Seisminius ?vykius lemia teritorijos seismotektoninis potencialas. Seismotektoninis potencialas ir Žem?s plutos deformacijos yra tarpusavyje susij? rei\\vskiniai, kuriuos sukelia dažnai tie patys giluminiai procesai Žem?s gelm?se. Žem?s plutos deformacij? tyrimas yra vienas iš informacijos šaltini? prognozuojant teritorijos seismotektonin? aktyvum?. Straipsnyje nagrin?jamos Žem?s plutos horizontaliosios deformacijos, nustatomi Žem?s plutos ?tempi? poky?iai Lietuvos teritorijoje pagal GPS matavim? duomenis. Atlikus tyrimus pagal pateikiam? Žem?s plutos horizontali?j? deformacij? ir ?tempi? tyrimo metodik?, gauti nauji horizontali?j? deformacij? charakteristik? bei ?tempi? poky?i? rezultatai ir nustatytos j? s?sajos su seismotektoniniu potencialu.

Zakarevi?ius, Algimantas; Stanionis, Arminas; Levinskait?, Daiva

2010-01-01

226

Molhabilidade: Tendncia de um determinado fludo espalhar ou aderir sobre uma superfcie slida  

E-print Network

Molhabilidade: Tendência de um determinado fluído espalhar ou aderir sobre uma superfície sólida óleo cru a. Interação polar entre óleo e superfície do sólido b. precipitação de um sólido, dependente asfalteno nos reservatórios de petróleo Rochas possuem normalmente um filme fino de água #12;As forças que

Loh, Watson

227

New cell-cell adhesion inhibitors from Streptomyces sp. UMA-044.  

PubMed

Three compounds, NP25301 (1), NP25302 (2) and bohemamine (3), inhibitors of cell adhesion based on LFA-1/ICAM-1, were isolated from the cultured broth of the strain Streptomyces sp. UMA-044. New compounds 1 and 2 were identified as 2-(3'-carbamoylphenoxy)acrylic acid methyl ester and deoxybohemamine, respectively, based on spectroscopic analyses. Compounds 1 approximately 3 inhibited adhesion of HL-60 cells to CHO-ICAM-1 cells at IC50 values of 29.5 microg/ml for 1, 24.3 microg/ml for 2, and 27.2 microg/ml for 3. PMID:14563155

Zhang, Qinglin; Schrader, Kevin K; ElSohly, Hala N; Takamatsu, Satoshi

2003-08-01

228

ABORDAGEM DA SEXUALIDADE HUMANA EM LIVRO DIDÁTICO DE CIÊNCIAS - DESVELANDO OS BASTIDORES DE UMA PROPOSTA. APPROACH OF HUMAN SEXUALITY IN SCIENCE TEXBOOKS - REVEALING THE BACKSTAGE OF A PROPOSAL  

Microsoft Academic Search

In this article, teachers with a long classroom militancy, describe the process and challenges to become authors of textbooks. After brief reflections on issues related to textbooks and curriculum, the authors show the background of the production process: studies, research, meetings and even internal conflicts and external pressures. They choose to highlight their approach in human sexuality and its interfaces

Margarida Carvalho de Santana; Mônica de Cássia; Vieira Waldhelm

229

Clinical expression of obsessive-compulsive disorder in women with bipolar disorder Expressão clínica do transtorno obsessivo- compulsivo em uma amostra de mulheres com transtorno de humor bipolar  

Microsoft Academic Search

Abstract Abstract Abstract Abstract Objective: Objective: Objective: Objective: Objective: To study clinical and psychopathological features of obsessive-compulsive disorder (OCD) in women with bipolar disorder (BD). Methods: Methods: Methods: Methods: Methods: Fifteen outpatients with concurrent bipolar disorder I (80.0%) or II (20.0%) and obsessive-compulsive disorder were studied. Most of them (80.0%) sought treatment for bipolar disorder. They were ascertained by means

Cilly Klüger Issler; José Antonio de Mello; Renata Sayuri Tamada; Angela Maria Schwartzmann; Roseli Gedanke Shavitt; Eurípedes Constantino Miguel; Beny Lafer

2005-01-01

230

7 CFR 1945.20 - Making EM loans available.  

Code of Federal Regulations, 2012 CFR

...2012-01-01 false Making EM loans available. 1945.20 Section 1945.20 Agriculture Regulations of the Department...CONTINUED) EMERGENCY Disaster Assistance-General § 1945.20 Making EM loans available. EM...

2012-01-01

231

Seven years photometry of the W UMa-type eclipsing binary V2612 Oph  

NASA Astrophysics Data System (ADS)

We present the first long-term Johnson U BV R observations and comprehensive photometric analysis of the W UMa-type eclipsing binary V2612 Oph. Observations in the time interval between 2003 and 2009 enabled us to reveal the seasonal and long-term variations of the light curve. Hence, we found that the mean brightness level of the light curve shows a variation with a period of 6.7 years. Maximum and minimum brightness levels of the light curve exhibit a variation from year to year which we attribute to a solar-like activity. The {O - C} variation of eclipse timings of the system shows a decreasing parabolic trend and reveals a period decrease at a rate of {P} = 6.27{×}10-7 day yr-1 with an additional low-amplitude sinusoidal variation that has a similar period as the long-term brightness variations. Our light curve analysis shows that the system is a W-subtype W UMa eclipsing binary. We calculated masses and radii of the primary and secondary components as M1 = 1.28 M_{?}, M2 = 0.37 M_{?} and R1 = 1.31 R_{?}, R2 = 0.75 R_{?}, respectively. The derived absolute photometric parameters %%derived from analysis results allow us to calculate a distance of 140 pc, which confirms that the system is a foreground star in the sky field of the Galactic open cluster NGC 6633.

Özdarcan, O.; Taš, G.

2014-10-01

232

Long-term Photometric Analysis of the Active W UMa-type System TU Bootis  

E-print Network

We present multi-color light curves for the W UMa-type eclipsing binary TU Boo for two epochs separated by 22 years. An analysis of the O-C diagram indicates the earlier observations took place right in the middle of a major period change, thus allowing for a unique study on mass transfer and period changes in this W UMa-type system. We compute model fits to our light curves, along with the only other published set, using the Wilson-Devinney program, and find temporally correlated changes in the size of the secondary component with anomalies in the O-C diagram. We investigate the cause of these changes and find support for the existence of rapid, large-scale mass transfer between the components. We postulate that this interaction allows them to maintain nearly equal surface temperatures despite having achieved only marginal contact. We also find support for the evolutionary scenario in which TU Boo has undergone a mass ratio reversal in the past due to large-scale mass transfer so that what is presently the secondary component of TU Boo is in an advanced evolutionary state, oversized due to a helium-enriched core, with a total system age of $\\geq$ 10 Gyr.

Jeffrey L. Coughlin; Horace A. Dale III; Richard M. Williamon

2008-07-09

233

School Budget Hold'em Facilitator's Guide  

ERIC Educational Resources Information Center

"School Budget Hold'em" is a game designed to help school districts rethink their budgeting process. It evolved out of Education Resource Strategies' (ERS) experience working with large urban districts around the country. "School Budget Hold'em" offers a completely new approach--one that can turn the budgeting process into a long-term visioning…

Education Resource Strategies, 2012

2012-01-01

234

EMS communications development: History and commentary  

Microsoft Academic Search

The history of emergency medical services (EMS) communication systems development from the FCC's first allocation of frequencies for hospitals and ambulances up to the present is discussed. Up until the late 1960's EMS communication systems were virtually nonexistent. Most early networks were developed by hospital associations for coordination of hospital disaster operations. Many significant changes were seeded in 1966. By

B. A. Smith

1976-01-01

235

EM international activities. February 1997 highlights  

SciTech Connect

EM International Highlights is a brief summary of on-going international projects within the Department of Energy`s Office of Environmental Management (EM). This document contains sections on: Global Issues, activities in Western Europe, activities in central and Eastern Europe, activities in Russia, activities in Asia and the Pacific Rim, activities in South America, activities in North America, and International Organizations.

NONE

1997-02-01

236

Contributo para a caracterização molecular de echinococcus granulosus em Portugal.  

E-print Network

??Mestrado em Ciências Biomédicas, Especialidade de Biologia Molecular em Medicina Tropical e Internacional A Equinococose/hidatidose – doença causada pela fase larvar (hidátide – vulgarmente conhecida… (more)

Beato, Sílvia Filipa Alves

2008-01-01

237

Project X RFQ EM Design  

SciTech Connect

Project X is a proposed multi-MW proton facility at Fermi National Accelerator Laboratory (FNAL). The Project X front-end would consist of an H- ion source, a low-energy beam transport (LEBT), a CW 162.5 MHz radio-frequency quadrupole (RFQ) accelerator, and a medium-energy beam transport (MEBT). Lawrence Berkeley National Laboratory (LBNL) and FNAL collaboration is currently developing the designs for various components in the Project X front end. This paper reports the detailed EM design of the CW 162.5 MHz RFQ that provides bunching of the 1-10 mA H- beam with acceleration from 30 keV to 2.1 MeV.

Romanov, Gennady; /Fermilab; Hoff, Matthew; Li, Derun; Staples, John; Virostek, Steve; /LBNL

2012-05-09

238

EM International, July 1994, Volume 2  

SciTech Connect

The Office of Environmental Management (EM) at the Department of Energy (DOE) is seeking out and leveraging foreign technology, data, and resources in keeping with EM`s mandate to protect public health and the environment through the safe and cost-effective remediation of the Department`s nuclear weapons sites. EM works closely with foreign governments, industry, and universities to obtain innovative environmental technologies, scientific and engineering expertise, and operations experience that will support EM`s objectives. Where appropriate, these international resources are used to manage the more urgent risks at our sites, secure a safe workplace, help build consensus on critical issues, and strengthen our technology development program. Through international agreements EM engages in cooperative exchange of information, technology, and individuals. Currently, we are managing agreements with a dozen countries in Europe, Latin America, and Asia. These agreements focus on environmental restoration, waste management, transportation of radioactive wastes, and decontamination and decommissioning. This publication contains the following articles: in situ remediation integrated program; in-situ characterization and inspection of tanks; multimedia environmental pollutant assessment system (MEPAS); LLNL wet oxidation -- AEA technology. Besides these articles, this publication covers: EU activities with Russia; technology transfer activities; and international organization activities.

Not Available

1994-10-01

239

BVRcIc Observations and Analyses on V2421 Cygni, a Precontact W UMa Binary  

NASA Astrophysics Data System (ADS)

We present the first precision BVRI light curves, synthetic light curve solutions, and a period study for the high amplitude solar type binary, V2421 Cygni. The light curves have the appearance of an Algol (EA) type; however, it is made up of dwarf solar type components in a detached mode with a period of only 0.6331 days with an amplitude of about a full magnitude, i.e., it is a precontact W UMa binary. Flare-like disruptions occur in the light curves following the primary and secondary eclipses possibly due to the line-of-sight track of a gas stream. An associated stream spot and splash spot cause bright equatorial spots on the stellar surface of the primary star. The more massive star is the gainer, making this system a classic, albeit dwarf, Algol.

Samec, R. G.; Shebs, Travis S.; Faulkner, D. R.; Van Hamme, W.; Mathis, R. F.

2014-01-01

240

Sonification of Kepler Field SU UMa Cataclysmic Variable Stars V344 Lyr and V1504 Cyg  

NASA Technical Reports Server (NTRS)

Sonification is the conversion of quantitative data into sound. In this work we explain the methods used in the sonification of light curves provided by the Kepler instrument from Q2 through Q6 for the cataclysmic variable systems V344 Lyr and V1504 Cyg . Both systems are SU UMa stars showing dwarf nova outbursts and superoutbursts as well as positive and negative superhumps. Focused sonifications were done from average pulse shapes of each superhump, and separate sonifications of the full, residual light curves were done for both stars. The audio of these data reflected distinct patterns within the evolutions of supercycles and superhumps that matched pervious observations and proved to be effective aids in data analysis.

Tutchton, Roxanne M.; Wood, Matt A.; Still, Martin D.; Howell, Steve B.; Cannizzo, John K.; Smale, Alan P.

2012-01-01

241

XMM-Newton observations of the polars EV UMa, RX J1002-19 and RX J1007-20  

E-print Network

We present XMM-Newton data of three strongly magnetic cataclysmic variables (polars) EV UMa, RX J1002-19 and RX J1007-20. These include the polar with the shortest orbital period (EV UMa) and the polar with one of the highest magnetic field strengths (RX J1007-20). They exhibit a range of X-ray spectral characteristics which are consistent with their known magnetic field strength. We find that two of the systems show evidence for an absorption dip in soft X-rays. Their profiles are well defined, implying that the stream is highly collimated. We determine the mass transfer rate for the two systems with known distances. We determine that the mass of the white dwarf in EV UMa and RX J1007-20 is ~1Msun while in RX J1002-19 it is closer to ~0.5Msun.

Gavin Ramsay; Mark Cropper

2002-09-05

242

Concepções dos cuidados em saúde mental por uma equipe de saúde da família, em perspectiva histórico-cultural The concept of mental care of a family health team from a historical-cultural perspective  

Microsoft Academic Search

The present study aims at analyzing the individual senses and social meanings of mental care actions carried out by professionals working in a Family Health Care Team. The study is based on Vigotsky's (1896-1934) theoretical perspective of a historical and cultural psychology. The work is part of a participant research and as such conducted in the context of a field

Marcelo Dalla Vecchia; Sueli Terezinha Ferreira Martins

243

O MODO DE FAZER SAÚDE: A FISIOTERAPIA NA RESIDÊNCIA MULTIPROFISSIONAL EM SAÚDE DA FAMÍLIA EM UMA UNIDADE BÁSICA THE MODE OF PROMOTING HEALTH: PHYSICAL THERAPY IN THE MULTIPROFESSIONAL RESIDENCY IN FAMILY HEALTH IN THE BASIC UNIT  

Microsoft Academic Search

This present study brings the experience of the resident in physical therapy, inserted in a Family Health Unit (FHU), in the city of Londrina, with the purpose of describing the role of the physical therapy resident in the FHU and characterizing the users who received healthcare. Data were collected from dossiers and worksheets of 501 patients from April 2007 to

Cristhiane Yumi Yonamine; Celita Salmaso Trelha

244

Kinesiology Undergraduate Student Learning Outcomes (EMS)  

E-print Network

1 Kinesiology Undergraduate Student Learning Outcomes (EMS) Kinesiology Undergraduate Student Learning Outcomes (PE) Kinesiology Graduate Program 1. Students will demonstrate knowledge of and skill sociocultural, historical, and philosophical perspectives on kinesiology. 4. Students will understand how motor

245

Structural Composites with Tuned EM Chirality.  

National Technical Information Service (NTIS)

We have developed and implemented methods to predict the overall EM properties tensors including the coupling tensors based on the geometry and microstructure of an array of scattering elements, and fabricated and measured both the HM and mechanical prope...

S. Nemat-Nasser

2009-01-01

246

Condições físicas em galáxias HII  

NASA Astrophysics Data System (ADS)

Galáxias HII são galáxias anãs de baixa luminosidade que apresentam alta taxa de formação estelar. Seus espectros são dominados por intensas linhas de emissão devido à fotoionização pela presença de um grande número de estrelas do tipo O e B. Nós apresentamos um catálogo espectrofotométrico de 111 galáxias HII observadas no telescópio 1.52m do ESO com o espectrógrafo Boller & Chivens. Determinamos propriedades estatísticas da amostra e derivamos condições físicas (temperatura eletrônica, densidade eletrônica) e abundâncias químicas. Para algumas galáxias, fomos também capazes de resolver espacialmente regiões de formação estelar individuais e determinar propriedades espectroscópicas para estas regiões separadamente, o que nos permitiu avaliar as flutuações das condições físico-químicas dentro das galáxias HII. Em particular, vimos que apesar das galáxias HII apresentarem formação estelar espalhada ao longo do corpo da galáxia, são objetos quimicamente homogêneos. A fim de estudar a evolução temporal dos objetos durante o tempo de vida das estrelas ionizantes construimos também alguns diagramas relacionando razões de linhas de emissão com a largura equivalente de Hb (EW(Hb)). Para interpretar tais diagramas utilizamos modelos de fotoionização para populações estelares integradas. Concluímos que as galáxias HII não correspondem a simples idéia de um burst instantâneo envolvido por um gás opaco aos fótons ionizantes e com densidade constante. As relações observadas entre razões de linhas e EW(Hb) podem ser melhor compreendidas se as galáxias HII apresentarem populações estelares mais velhas, que contribuem para o contínuo óptico observado.

Kehrig, C.; Telles, E.; Cuisinier, F.

2003-08-01

247

Qualidade de vida de estudantes de enfermagem de uma faculdade privada Life quality of nursing students from a private university  

E-print Network

Qualidade de vida de estudantes de enfermagem de uma faculdade privada Life quality of nursing was designed with the objective of evaluating the quality of life of students in the nursing course. Resulted in a sample of 192 (one hundred ninety-two) students. The diagnosis showed that most students

Paris-Sud XI, Université de

248

A Procedural Learning Mechanism for Novel Skill Acquisition Sidney D'Mello, Uma Ramamurthy, Aregahegn Negatu, & Stan Franklin  

E-print Network

|franklin|urmmrthy|asnegatu}@memphis.edu Abstract In this paper we attempt to develop mechanisms for procedural memory and procedural learning components of the LIDA architecture are perceptual associative memory, working mem- ory, episodic memoryA Procedural Learning Mechanism for Novel Skill Acquisition Sidney D'Mello, Uma Ramamurthy

Ramamurthy, Uma

249

SOFIS FTS EM test results  

NASA Astrophysics Data System (ADS)

The Solar Occultation FTS for Inclined-orbit Satellite (SOFIS) is a solar occultation Fourier transform spectrometer developed by the Ministry of the Environment (MOE) in Japan for the Global Change Observation Mission-A1 (GCOM-A1) satellite. GCOM-A1 will be placed in a 650 km non-sun-synchronous orbit, with an inclination angle of 69 degrees. ABB-Bomem is a sub-contractor of NTSpace (NEC-Toshiba Space) for the design and manufacturing of the FTS Engineering Model of SOFIS. SOFIS measures the vertical profile of the atmospheric constituents with 0.2 cm-1 spectral resolution for the spectral range covering 3-13 ?m. The atmospheric vertical resolution of SOFIS is 1 km. The target of SOFIS measurements is a global distribution of O3, HNO3, NO2, N2O, CH4, H2O, CO2, CFC-11, CFC-12, ClONO2, aerosol extinction, atmospheric pressure and temperature. NTSpace in Japan is the prime contractor of SOFIS. The spectrometer is an adapted version of the classical Michelson interferometer using an optimized optical layout and moving retro-reflectors. A solid-state laser diode operating at 1550 nm is used as metrology source of the interferometer. Its highly folded optical design results in a high performance instrument with a compact size. SOFIS FTS implements high performance control techniques to achieve outstanding speed stability of the moving mechanism. This paper describes the test activities of the SOFIS-FTS Engineering Model (EM) and preliminary results. The performances of the FTS are presented in terms of key parameters like signal-to-noise ratio, modulation efficiency and stability. Spectra acquired are shown and test methodology and analyses are presented. Lessons learned during assembly, integration and testing are described as well as improvements planned to be implemented in the Flight Model.

Soucy, Marc-Andre A.; Levesque, Luc E.; Tanii, Jun; Kawashima, Takahiro; Nakajima, Hideaki

2003-04-01

250

Cultura, património e turismo: uma trilogia possível? Sons, silêncio e outros sentidos no mosteiro de S. Bento de Cástris.  

E-print Network

??Trabalho de Projecto Segundo Ciclo em Práticas Culturais para Municípios Cultura, Património e Turismo são três conceitos indissociáveis. Cultura e Património (con)fundem-se para possibilitar a… (more)

Freire, Mariana Courinha de Torres Vaz

2011-01-01

251

New observations, photometric study and preliminary elements of the W UMa system DF CVn  

NASA Astrophysics Data System (ADS)

CCD (V) light curve of the EW-type eclipsing variable DF CVn was obtained during seven nights in April-May, 2004. With our data we were able to determine 4 new times of minimum light. The light curve appears to exhibit a typical O'Connell effect, with Maximum I brighter than Maximum II by 0.013 mag. in V. Two Wilson-Devinney (WD) code working sessions, using the V light curve, were done with and without spots. The analysis of the results shows that the best fit was obtained with the spotted solution and indicates contact geometry. The photometric mass ratio of the system is found to be q = 0.347 and its inclination i = 72°, the primary minimum shows a transit. The star may be classified as an A-type W UMa system. Assuming a reasonable value for the mass of the primary component an estimate of the absolute elements of DF CVn has been made, with the assumption that the primary has a mass corresponding to its spectral type according to Straizys and Kuriliene (1981).

Acerbi, F.; Barani, C.; Martignoni, M.

2005-06-01

252

Precursor outbursts and superoutbursts in the SU UMa-type dwarf nova NN Camelopardalis  

NASA Astrophysics Data System (ADS)

We report photometry of three outbursts of NN Cam in 2007, 2008 and 2009. The 2007 event started with a normal outburst, lasting about 4 days, which was a precursor to a superoutburst lasting at least 13 days. Both the precursor and the superoutburst had an amplitude of 4.9 mag above mean quiescence. Superhumps with a maximum peak-to-peak amplitude of 0.22 mag were detected during the superoutburst, with a mean superhump period Psh= 0.07385(56)d. Psh decreased continuously with dPsh/dt= ?1.72(23)x10^-3. We used our measurement to confirm that the shorter of two possible values of Porb reported by another researcher is correct; Porb= 0.0717d. The 2008 outburst was rather poorly observed, although we present evidence that this too may have been a superoutburst. The 2009 event was also a superoutburst, with Psh= 0.07414(44)d, but we could find no evidence for a precursor. From the 2007 and 2009 data, we report a superhump period excess of e= 0.030(8) to 0.034(6), which is typical for SU UMa dwarf novae of similar orbital period, and estimate the binary mass ratio q= Mwd/Msec~ 0.11 to 0.17.

Shears, J.; Foote, J.; Mack Julian, W.; Krajci, T.; Kudzej, I.; Miller, I.; Morelle, E.; Sabo, R.; Solovieva, I.; Staels, B.; Vanmunster, T.

2011-12-01

253

BVRI Photometric and Polarimetric studies of W UMa type Eclipsing Binary FO Hydra  

E-print Network

We present analysis of optical photometric and polarimetric observations of contact binary system FO Hydra (FO Hya). The computed period of the system is 0.469556+/-0.000003 days. An O-C curve analysis indicates an increase in its period by 5.77x10^{-8} day yr^{-1}. The photometric light curves are analyzed using Wilson-Devinney code (WD). The present analysis shows that FO Hya is a B-subtype of W UMa type contact binary. The radii and mass of primary and secondary components are found, respectively, to be R_1 = 1.62+/-0.03 R_sun and R_2 = 0.91+/-0.02 R_sun, and M_1 = 1.31+/-0.07 M_sun and M_2 = 0.31+/-0.11 M_sun. The light curve shape shows small asymmetries around the primary and secondary maxima. This may be due to the presence of dark spots on the components. The polarimetric observations yield average values of its polarization to be 0.18+/-0.03, 0.15+/-0.03, 0.17+/-0.02 and 0.15+/-0.02 per cent in B, V, R and I bands, respectively. These values are appreciably lower than the typical polarization of W UM...

Prasad, Vinod; Patel, Manoj K; Srivastava, D C

2012-01-01

254

Optimization of ultrasonic\\/microwave assisted extraction (UMAE) of polysaccharides from Inonotus obliquus and evaluation of its anti-tumor activities  

Microsoft Academic Search

Recently, the use of ultrasonic and microwave has attracted considerable interest as an alternative approach to the traditional extraction methods. In this paper, in order to maximize the yield and purity of polysaccharides from Inonotus obliquus, response surface methodology (RSM) was employed to optimize the ultrasonic\\/microwave assisted extraction (UMAE) conditions. The results indicated that the optimal conditions for UMAE were

Yiyong Chen; Xiaohong Gu; Sheng-quan Huang; Jinwei Li; Xin Wang; Jian Tang

2010-01-01

255

Ver e inovar: Actividades experimentais em Ciências Físico-Químicas  

Microsoft Academic Search

Resumo. O ensino experimental das Ciências constitui um dos aspectos fulcrais da reorganização curricular. Sendo uma preocupação do projecto Interacção e Conhecimento contribuir para cenários de aprendizagem mais inclusivos, tem existido uma preocupação de adaptar diversas unidades curriculares para alunos categorizados como apresentando NEE. Assim, as actividades experimentais relacionadas com o Som (Física) e os Tipos de Reacções Químicas, foram

Maria Albertina da Silva; Margarida César

256

Tour of the Electromagnetic Spectrum (EMS) Videos  

NSDL National Science Digital Library

These videos introduce middle- and high school-age learners to the electromagnetic spectrum. The product consists of 8 animations including an introduction to electromagnetic waves and one animation for each wavelength of the EM spectrum (Radio, Microwave, Infrared, Visible, Ultraviolet, X-Rays and Gamma Rays). Each wavelength of the EM spectrum offers a construct to illustrate and teach about NASA sensors, missions, and science. Emphasis is placed on relevant science, such as lunar exploration, and hot science topics, such as climate change. The examples and narrative for each wavelength animation build on the learnersâ prior knowledge then introduces examples from NASA missions. These examples explore the use of spectral analysis and visualizations that help scientists make discoveries about the world around us using EM waves.

Benesch, Troy

2009-01-01

257

THE FIRST PHOTOMETRIC INVESTIGATION OF THE NEGLECTED W-UMa-TYPE BINARY STAR UZ CMi  

SciTech Connect

UZ CMi was a W-UMa-type binary star found more than 80 years ago. However, it has been neglected in photometric investigations. Here, the first complete light curves in the B, V, R, and I bands are presented and analyzed using the Wilson and Devinney method. It is discovered that UZ CMi is a contact binary (f = 38.4({+-} 2.3)%) with a mass ratio of 0.45. The derived orbital inclination (i = 87 Degree-Sign ) indicates that it is a total eclipsing binary, which suggests that the determined parameters are reliable. By using 17 new eclipse times together with those collected from the literature, we found that the general trend of the observed-calculated (O - C) curve shows an upward parabolic variation that corresponds to a long-term increase in the orbital period at a rate of P-dot = +4.1 x 10{sup -8} days yr{sup -1}. The continuous increase may be caused by a mass transfer from the less massive component to the more massive one. This suggests that UZ CMi is in the thermal relaxation oscillation controlled stage of the evolutionary scheme proposed by Qian. UZ CMi will oscillate around a critical mass ratio and the contact configuration cannot be broken. After the upward parabolic change was removed, the (O - C){sub 2} curve of the photoelectric and charge-coupled device data revealed a cyclic variation with a small amplitude of 0.0026 days and a period of 21.1 yr. The cyclic change was analyzed for the light-travel time effect via the presence of an extremely cool stellar companion.

Qian, S.-B.; Li, K.; Liao, W.-P.; Liu, L.; Zhu, L.-Y.; He, J.-J.; Wang, J.-J.; Zhao, E.-G., E-mail: qsb@ynao.ac.cn [National Astronomical Observatories/Yunnan Observatory, Chinese Academy of Sciences (CAS), P.O. Box 110, 650011 Kunming (China)

2013-04-15

258

FIRST PHOTOMETRIC INVESTIGATION OF THE NEWLY DISCOVERED W UMa-TYPE BINARY STAR MR Com  

SciTech Connect

By analyzing multi-color light curves of the newly discovered W UMa-type binary, MR Com, we discovered that it is a shallow-contact binary with a degree of contact factor of f = 10.0% {+-} 2.1%. Photometric solutions reveal that MR Com is a W-type system with a mass ratio of q = 3.9 where the less massive component is about 90 K hotter than the more massive one. By investigating all of the available times of minimum light, we found that the general trend of the Observed-Calculated (O - C) curve shows a downward parabolic variation while it undergoes a cyclic variation with a small amplitude of 0.0031 days and a period of 10.1 yr. The downward parabolic change corresponds to a long-term decrease in the orbital period at a rate of P-dot = -5.3 x 10{sup -7} days yr{sup -1} that may be caused by a combination of a mass transfer and an angular momentum loss (AML) via magnetic braking. Among the 16 shallow-contact systems with a decreasing orbital period, MR Com has the lowest mass ratio (e.g., 1/q = 0.26). The shallow-contact configuration, the low-mass ratio, and the long-term period decrease all suggest that systems similar to MR Com are on the AML-controlled stage of the evolutionary scheme proposed by Qian. They will oscillate around a critical mass ratio and evolve into a deep contact with a higher mass ratio. The small-amplitude cyclic change in the O - C curve was analyzed for the light-travel time effect via the presence of an extremely cool stellar companion.

Qian, S.-B.; Liu, N.-P.; Liao, W.-P.; He, J.-J.; Liu, L.; Zhu, L.-Y.; Wang, J.-J.; Zhao, E.-G., E-mail: qsb@ynao.ac.cn [Yunnan Observatories, Chinese Academy of Sciences (CAS), P.O. Box 110, 650011 Kunming (China)

2013-08-01

259

UBVRI Observations, Analysis and Spectra of the Mature W UMa Contact Binary, V444 And  

NASA Astrophysics Data System (ADS)

We present the first precision UBVRI light curves, synthetic light curve solution, a period study and spectra for the V444 Andromedae, an FO V contact W UMa binary. Observations were taken at Lowell Observatory with the 0.81-m reflector from 28 through 30 September 2012 and the spectra at Dominion Astrophysical Observatory’s (DAO) with the 1.8m telescope on 22 July 2013 at a resolution of 60 Å/mm. We determined three times of minimum light from these observations, JD Hel Min I = 2456199.0239±0.0011, 2456199.9616± 0.0015 and JD Hel Min II = 2456198.7907±0.0005. From our period study we determined an improved linear ephemeris, J.D. Hel Min I = 2456199.9618±0.0003d + 0.46877942±0.00000005×E The period has been stable over the past 9.6 years 7500 orbits). After an extensive mass ratio-search, the lowest residual mass ratio was found to be 0.48. Our final Wilson-Devinney Program computation determined that the system is an A-type W U Ma contact binary with a fill-out of nearly 51%. Despite its temperature (7200-7300 K), two magnetic spots were found on the primary component, a 10 degree radius equatorial dark spot, T-factor=0.88 and a 23 degree radius near polar hot spot, T-factor=1.10. The component temperature difference is only ~80K. These parameters tell us that the V444 And is a mature solar type binary.

Shebs, Travis; Samec, R. G.; Monroe, S.; Faulkner, D. R.; Robb, R. M.; Van Hamme, W. V.; Chamberlain, H.

2014-01-01

260

The Low-Mass Limit for Total Mass of W UMa-type Binaries  

E-print Network

The observations of W UMa type stars show a well-defined short-period limit of 0.22 d, which is equivalent to a lower mass limit of approximately 1 solar mass for the total binary mass. It is currently believed that cool contact binaries are formed from detached binaries losing angular momentum (AM) via a magnetized wind. Orbital evolution of detached binaries with various component masses was followed until the primary component reached the critical Roche surface and the Roche lobe overflow (RLOF) began. It was assumed that the minimum initial, i.e. ZAMS, orbital period of such binaries is equal to 2 d and that the components lose AM just as single stars. According to the mass-dependent formula for AM loss rate of single stars, derived in this paper, the AM loss time scale increases substantially with decreasing stellar mass. The formula was applied to binaries with the initial primary component masses between 1.0 and 0.6 solar mass and two values of mass ratio q=1 and 0.5. Detailed calculations show that the time needed to reach RLOF by a 1 solar mass primary is of the order of 7.5 Gyr, but it increases to more than 13 Gyr for a binary with an initial primary mass of 0.7 solar mass. Binaries with less massive primaries have not yet had time to reach RLOF even within the age of the Universe. This sets a lower mass limit for the presently existing contact binaries

K. Stepien

2007-01-18

261

V344 Lyrae: A Touchtone SU UMa Cataclysmic Variable in the Kepler Field  

NASA Technical Reports Server (NTRS)

We report on the analysis of the Kepler short-cadence (SC) light curve of V344 Lyr obtained during 2009 June 20 through 2010 Mar 19 (Q2-Q4). The system is an SU UMa star showing dwarf nova outbursts and superoutbursts, and promises to be a touchstone for CV studies for the foreseeable future. The system displays both positive and negative super humps with periods of 2.20 and 2.06-hr, respectively, and we identify an orbital period of 2.11-hr. The positive super humps have a maximum amplitude of approximately 0.025-mag, the negative super humps a maximum amplitude of approximately 0.8 mag, and the orbital period at quiescence has an amplitude of approximately 0.025 mag. The quality of the Kepler data is such that we can test vigorously the models for accretion disk dynamics that have been emerging in the past several years. The SC data for V344 Lyr are consistent with the model that two physical sources yield positive superhumps: early in the superoutburst. the superhump signal is generated by viscous dissipation within the periodically flexing disk. but late in the superoutburst, the signal is generated as the accretion stream bright spot sweeps around the rim of the non-axisymmetric disk. The disk super humps are roughly anti-phased with the stream/late superhumps. The V344 Lyr data also reveal negative super humps arising from accretion onto a tilted disk precessing in the retrograde direction, and suggest that negative superhumps may appear during the decline of DN outbursts. The period of negative superhumps has a positive P(raised dot) in between outbursts.

Smale, Alan P.; Wood, Matt A.; Still, Martin D.; Howell, Steve B.; Cannizzo, John K.

2012-01-01

262

Changes in specific anti-egg antibody levels following treatment with praziquantel for Schistosoma haematobium infection in children  

E-print Network

of Infection and Immunity, IBLS, University of Glasgow, G12 8QQ, Scotland, UK SUMMARY Fifty-seven children 6 haematobium infection in children F.MUTAPI1 , P.D.NDHLOVU2 , P.HAGAN3 & M.E.J.WOOLHOUSE1* 1 Wellcome Trust children were confirmed egg negative six weeks after treatment, and re- infection prevalence was 4% at 18

Mutapi, Francisca

263

Efficacy of Droncit R Spot-on (praziquantel) 4% w\\/v against immature and mature Echinococcus multilocularis in cats  

Microsoft Academic Search

The causative agent of alveolar hydatidosis in humans, the fox tapeworm Echinococcusmultilocularis, is extending its geographical range in Europe and has been found in domestic cats in some areas. A dermally applied cestocidal treatment for domestic cats has been developed and the efficacy of this treatment is reported. Thirty purpose-bred cats were experimentally infected each with 10?000 protoscoleces of Echinococcusmultilocularis.

David J Jenkins; Thomas Romig

2000-01-01

264

Risk Communication Within the EM Program  

SciTech Connect

The U.S. Department of Energy Environmental Management program (EM) conducts the most extensive environmental remediation effort in the world. The annual EM budgets have exceeded $6,000,000,000 for approximately ten years and EM has assumed responsibility for the cleanup of the largest DOE reservations (i.e., at Hanford, Washington, Aiken, South Carolina, and Idaho Falls, Idaho) as well as the facilities at Rocky Flats, Colorado and in Ohio. Each of these sites has areas of extensive radioactive and chemical contamination, numerous surplus facilities that require decontamination and removal, while some have special nuclear material that requires secure storage. The EM program has been criticized for being ineffective (1) and has been repeatedly reorganized to address perceived shortcomings. The most recent reorganization was announced in 2001 to become effective at the beginning of the 2003 Federal Fiscal Year (i.e., October 2002). It was preceded by a ''top to bottom'' review (TTBR) of the program (2) that identified several deficiencies that were to be corrected as a result of the reorganization. One prominent outcome of the TTBR was the identification of ''risk reduction'' as an organizing principle to prioritize the activities of the new EM program. The new program also sought to accelerate progress by identifying a set of critical activities at each site that could be accelerated and result in more rapid site closure, with attendant risk, cost, and schedule benefits. This paper investigates how the new emphasis on risk reduction in the EM program has been communicated to EM stakeholders and regulators. It focuses on the Rocky Flats Environmental Technology Site (RFETS) as a case study and finds that there is little evidence for a new emphasis on risk reduction in EM communications with RFETS stakeholders. Discussions between DOE and RFETS stakeholders often refer to ''risk,'' but the word serves as a placeholder for other concepts. Thus ''risk'' communication at RFETS is lively and involves important issues, but often does not inform participants about true ''risk reduction.''

Edelson, M.

2003-02-26

265

7 CFR 1945.35 - Special EM loan training.  

Code of Federal Regulations, 2012 CFR

...2012-01-01 false Special EM loan training. 1945.35 Section 1945.35 Agriculture Regulations of the Department...CONTINUED) EMERGENCY Disaster Assistance-General § 1945.35 Special EM loan training. (a)...

2012-01-01

266

7 CFR 1945.35 - Special EM loan training.  

Code of Federal Regulations, 2010 CFR

...2009-01-01 true Special EM loan training. 1945.35 Section 1945.35 Agriculture Regulations of the Department...CONTINUED) EMERGENCY Disaster Assistance-General § 1945.35 Special EM loan training. (a)...

2010-01-01

267

7 CFR 1945.35 - Special EM loan training.  

Code of Federal Regulations, 2011 CFR

...2009-01-01 true Special EM loan training. 1945.35 Section 1945.35 Agriculture Regulations of the Department...CONTINUED) EMERGENCY Disaster Assistance-General § 1945.35 Special EM loan training. (a)...

2011-01-01

268

EM-ONE : an architecture for reflective commonsense thinking  

E-print Network

This thesis describes EM-ONE, an architecture for commonsense thinking capable of reflective reasoning about situations involving physical, social, and mental dimensions. EM-ONE uses as its knowledge base a library of ...

Singh, Pushpinder, 1972-2006.

2005-01-01

269

Survey of period variations of superhumps in SU UMa-type dwarf novae. V. The fifth year (2012-2013)  

NASA Astrophysics Data System (ADS)

Continuing the project described in Kato et al. (2009, PASJ, 61, S395), we collected times of superhump maxima for SU UMa-type dwarf novae mainly observed during the 2012-2013 season. We found three objects (V444 Peg, CSS J203937, and MASTER J212624) having strongly positive period derivatives despite the long orbital period (Porb). By using the period of growing stage (stage A) superhumps, we obtained mass ratios for six objects. We characterized nine new WZ Sge-type dwarf novae. We made a pilot survey of the decline rate in the slowly fading parts of SU UMa-type and WZ Sge-type outbursts. The decline time scale was found to generally follow an expected P_orb^{1/4} dependence, and WZ Sge-type outbursts also generally follow this trend. There are some objects which show slower decline rates, and we consider these objects good candidates for period bouncers. We also studied unusual behavior in some objects, including BK Lyn which made a transition from an ER UMa-type state to a novalike (standstill) state in 2013, and unusually frequent occurrences of superoutbursts in NY Ser and CR Boo. We applied the least absolute shrinkage and selection operator (Lasso) power spectral analysis, which has been proven to be very effective in analyzing the Kepler data, to the ground-based photometry of BK Lyn, and detected a dramatic disappearance of the signal of negative superhumps in 2013. We suggested that the mass-transfer rates did not strongly vary between the ER UMa-type state and novalike state in BK Lyn, and this transition was less likely caused by a systematic variation of the mass-transfer rate.

Kato, Taichi; Hambsch, Franz-Josef; Maehara, Hiroyuki; Masi, Gianluca; Nocentini, Francesca; Dubovsky, Pavol A.; Kudzej, Igor; Imamura, Kazuyoshi; Ogi, Minako; Tanabe, Kenji; Akazawa, Hidehiko; Krajci, Thomas; Miller, Ian; de Miguel, Enrique; Henden, Arne; Noguchi, Ryo; Ishibashi, Takehiro; Ono, Rikako; Kawabata, Miho; Kobayashi, Hiroshi; Sakai, Daisuke; Nishino, Hirochika; Furukawa, Hisami; Masumoto, Kazunari; Matsumoto, Katsura; Littlefield, Colin; Ohshima, Tomohito; Nakata, Chikako; Honda, Satoshi; Kinugasa, Kenzo; Hashimoto, Osamu; Stein, William; Pickard, Roger D.; Kiyota, Seiichiro; Pavlenko, Elena P.; Antonyuk, Oksana I.; Baklanov, Aleksei V.; Antonyuk, Kirill; Samsonov, Denis; Pit, Nikolaj; Sosnovskij, Aleksei; Oksanen, Arto; Harlingten, Caisey; Tyyskä, Jenni; Monard, Berto; Shugarov, Sergey Yu.; Chochol, Drahomir; Kasai, Kiyoshi; Maeda, Yutaka; Hirosawa, Kenji; Itoh, Hiroshi; Sabo, Richard; Ulowetz, Joseph; Morelle, Etienne; Michel, Raúl; Suárez, Genaro; James, Nick; Dvorak, Shawn; Voloshina, Irina B.; Richmond, Michael; Staels, Bart; Boyd, David; Andreev, Maksim V.; Parakhin, Nikolai; Katysheva, Natalia; Miyashita, Atsushi; Nakajima, Kazuhiro; Bolt, Greg; Padovan, Stefano; Nelson, Peter; Starkey, Donn R.; Buczynski, Denis; Starr, Peter; Goff, William N.; Denisenko, Denis; Kochanek, Christopher S.; Shappee, Benjamin; Stanek, Krzysztof Z.; Prieto, José L.; Itagaki, Koh-ichi; Kaneko, Shizuo; Stubbings, Rod; Muyllaert, Eddy; Shears, Jeremy; Schmeer, Patrick; Poyner, Gary; Rodríguez-Marco, Miguel

2014-04-01

270

UNIVERSIDADE DE BRASLIA PROGRAMA DE PS-GRADUAO EM ECONOMIA  

E-print Network

1 UNIVERSIDADE DE BRASÍLIA PROGRAMA DE P�S-GRADUA��O EM ECONOMIA EDITAL No. 04/2011 SELE��O DE CANDIDATOS �S VAGAS DO PROGRAMA DE P�S-GRADUA��O EM ECONOMIA PARA O CURSO DE MESTRADO PROFISSIONAL EM ECONOMIA ­ AREA DE CONCENTRA��O EM GEST�O ECON�MICA DE FINAN�AS P�BLICAS PARA O SEGUNDO PERÍODO LETIVO DE

Lucero, Jorge Carlos

271

UNIVERSIDADE DE BRASLIA PROGRAMA DE PS-GRADUAO EM ECONOMIA  

E-print Network

1 UNIVERSIDADE DE BRASÍLIA PROGRAMA DE P�S-GRADUA��O EM ECONOMIA EDITAL No. 4/2013 SELE��O DE CANDIDATOS �S VAGAS DO PROGRAMA DE P�S-GRADUA��O EM ECONOMIA PARA O CURSO DE MESTRADO PROFISSIONAL EM ECONOMIA ­ AREA DE CONCENTRA��O EM GEST�O ECON�MICA DE FINAN�AS P�BLICAS PARA O SEGUNDO PERÍODO LETIVO DE

Maier, Rudolf Richard

272

UNIVERSIDADE DE BRASLIA PROGRAMA DE PS-GRADUAO EM ECONOMIA  

E-print Network

1 UNIVERSIDADE DE BRASÍLIA PROGRAMA DE P�S-GRADUA��O EM ECONOMIA EDITAL No. 5/2013 SELE��O DE CANDIDATOS �S VAGAS DO PROGRAMA DE P�S-GRADUA��O EM ECONOMIA PARA O CURSO DE MESTRADO PROFISSIONAL EM ECONOMIA ­ AREA DE CONCENTRA��O EM GEST�O ECON�MICA DE FINAN�AS P�BLICAS PARA O SEGUNDO PERÍODO LETIVO DE

Maier, Rudolf Richard

273

On Convergence Properties of the EM Algorithm for Gaussian Mixtures  

Microsoft Academic Search

We build up the mathematical connection between the Expectation-Maximization (EM) algorithm and gradient-based approaches for maximum likelihood learning of finite gaussian mixtures. We show that the EM step in parameter space is obtained from the gradient via a projection matrix P, and we provide an explicit expression for the matrix. We then analyze the convergence of EM in terms of

Lei Xu; Michael I. Jordan

1996-01-01

274

GEOBULLETIN NOvEmBEr 15Th  

E-print Network

to hydrothermal convection of groundwater connected to surface water Thermal springs are ubiquitous features whose;GEOBULLETIN NOvEmBEr 15Th 2013 - 2 - hydrothermal convection cells circulating groundwater within the near hydrothermal circulation of groundwater. For example, these requirements are met in many areas within

Carlson, Anders

275

EMS response to an airliner crash.  

PubMed

This report of an aircraft crash at a major airport in Kingston, Jamaica examines the response of the local Emergency Medical Services (EMS). Factors that impacted the response are discussed, and the need for more disaster simulation exercises is highlighted. The objective of this case report was to document the response of EMS personnel to the crash of American Airlines Flight 331, and to utilize the information to examine and improve the present protocol. While multiple errors can occur during a mass-casualty event, these can be reduced by frequent simulation exercises during which various personnel practice and learn designated roles. Efficient triage, proper communication, and knowledge of the roles are important in ensuring the best possible outcome. While the triage system and response of the EMS personnel were effective for this magnitude of catastrophe, more work is needed in order to meet predetermined standards. Ways in which this can be overcome include: (1) hosting more disaster simulation exercises; (2) encouraging more involvement with first responders; and (3) strengthening the links in the local EMS system. Vigorous public education must be instituted and maintained. PMID:22853919

Dasgupta, Shuvra; French, Simone; Williams-Johnson, Jean; Hutson, Rhonda; Hart, Nicole; Wong, Mark; Williams, Eric; Espinosa, Kurdell; Maycock, Celeste; Edwards, Romayne; McCartney, Trevor; Cawich, Shamir; Crandon, Ivor

2012-06-01

276

CNMP, CSP, EMS and Writing It Down  

E-print Network

by farmers, leading to... · Increasing importance of "writing it down" #12;Examples.. · NMP, CNMP · PMPOp & plan for more · III - meet all natural resource concerns #12;NMP & CNMP · NMP in WI rules; CNMP and erosion #12;EMS is HQ · CSP, NMP, PMP, CNMP alphabet soup · Are components of an Environmental Management

Balser, Teri C.

277

CURSO DE PS-GRADUAO EM METEOROLOGIA  

E-print Network

CURSO DE P�S-GRADUA��O EM METEOROLOGIA Coordenadora Acadêmica Maria Paulete Pereira Martins Membros Bueno Pereira, Ph.D., W.M.Rice University, 1980 Gilberto Fernando Fisch, Doutor, INPE, 1995 Iracema, INPE, 2002 Maria Paulete Pereira Martins, Doutora, INPE, 1996 Marley Cavalcante de Lima Moscati

278

CURSO DE PS-GRADUAO EM METEOROLOGIA  

E-print Network

CURSO DE P�S-GRADUA��O EM METEOROLOGIA Coordenadora Acadêmica Maria Paulete Pereira Martins Bueno Pereira, Ph.D., W.M.Rice University, 1980 Gilberto Fernando Fisch, Doutor, INPE, 1995 Iracema, INPE, 2002 Maria Paulete Pereira Martins, Doutora, INPE, 1996 Marley Cavalcante de Lima Moscati

279

CURSO DE PS-GRADUAO EM METEOROLOGIA  

E-print Network

CURSO DE P�S-GRADUA��O EM METEOROLOGIA Coordenadora Acadêmica Maria Paulete Pereira Martins-USP, 2002 �nio Bueno Pereira, Ph.D., W.M.Rice University, 1980 Gilberto Fernando Fisch, Doutor, INPE, 1995, INPE, 2002 Maria Paulete Pereira Martins, Doutora, INPE, 1996 Marley Cavalcante de Lima Moscati

280

GEOBULLETIN NOvEmBEr 8Th  

E-print Network

GEOBULLETIN NOvEmBEr 8Th 2013 - 1 - GeoBulletin is distributed weekly, by E-mail. Contributions are requested! If you have a news item, a request, an announcement etc. email it to geodept@geology.wisc.edu or leave it at the office, Room 225 by Noon on Wednesday. WEEKS LECTURE - FALL 2013 Nov. 8 Graham Kent

Carlson, Anders

281

Regional EM studies in the 80's  

NASA Astrophysics Data System (ADS)

The review describes in broad terms the development of regional EM studies during the last five-six years. Large simultaneous magnetometer arrays, broadband and dense profiling with five component instruments, the use of remote reference techniques and in-field data processing have increased both the number and the quality of EM surveys. The increase has been strong all over the world. An extensive list of references, divided geographically, is presented. Selected examples of regional resisitivity-versus-depth curves are shown for Africa, the Baikal region, the Baltic Shield, the Canadian Shield, the Carpathian regions, the Central Andes, Iceland, India, the Juan de Fuca Plate, the Münsterland Basin, the Rio Grande rift, the Scottish Caledonides, the Tasman Sea, and for the United States in general. Because of the influence of tectonic settings and the metamorphic grade of rocks, only qualitative aspects of the results are relevant. ‘Classical’ array studies, especially in Australia, in the Carpathian regions, in India, in North Germany and in Scotland have been reinterpreted and completed with more accurate 2D modelling and dense MT profiling. In the USA and Canada also new regions have been surveyed extensively. New regional EM work has been conducted extensively on the Baltic Shield and in Central and North Africa, Siberia, China, in the areas around the Caspian and Black Seas and in South America. The newest studies are supported by or compared with other geophysical data, which also are used in extrapolating for missing EM data density. There are several successful large-scale projects in operation: the European Geotraverse (EGT), the KAPG International Geotraverses and the EMSLAB project (with its first preliminary results). Regional EM studies have been increasingly applied to geothermal, hydrocarbon and mineral prospecting as well as local structural studies, e.g. studies of sites for nuclear waste disposal.

Hjelt, S. E.

1987-09-01

282

Modelling and design for PM/EM magnetic bearings  

NASA Technical Reports Server (NTRS)

A mathematical model of a permanent magnet/electromagnet (PM/EM) radially active bearing is presented. The bearing is represented by both a reluctance model and a stiffness model. The reluctance model analyzes the magnetic circuit of the PM/EM bearings. By combining the two models, the performance of the bearing can be predicted given geometric dimensions, permanent magnet strength, and the parameters of the EM coils. The overall bearing design including the PM and EM design is subject to the performance requirement and physical constraints. A study of these requirements and constraints is discussed. The PM design is based on the required magnetic flux for proper geometric dimensions and magnet strength. The EM design is based on the stability and force slew rate consideration, and dictates the number of turns for the EM coils and the voltage and current of the power amplifier. An overall PM/EM bearing design methodology is proposed and a case study is also demonstrated.

Pang, D.; Kirk, J. A.; Anand, D. K.; Johnson, R. G.; Zmood, R. B.

1992-01-01

283

The 2008-2009 Eruption in Halema`uma`u Crater, Kilauea Volcano  

NASA Astrophysics Data System (ADS)

Early in the 26th year of Kilauea volcano’s ongoing east rift zone eruption, a distinct increase in activity was detected at Kilauea summit. By February 2008, the southern part of the summit caldera was bathed in high concentrations of SO2 prompting Hawai`i Volcanoes National Park to close public access. A vigorous fuming area at the base of the east wall of Halema`uma`u Crater was noted on March 12, and the first throat-clearing explosion occurred from that location a week later. This, the first explosive eruption of Kilauea's summit since 1924, was followed by 7 more before the first major vent collapse in early December 2008 buried the lava column beneath rubble, extinguished vent glow, and reduced gas emissions. The vent slowly came back to life in early 2009, exhibiting behavior similar to that in 2008, until another major collapse in mid-2009 reburied the vent and again extinguished glow and reduced gas emissions. As of August 2009, glow had returned and gas emissions had increased, a total of 2,200 tonnes of lithic and juvenile tephra had been erupted, and the dimensions of the vent opening in the crater floor increased to 125 x 133 m. Chemical uniformity of magma erupted from the summit and rift zone vents unambiguously demonstrate their direct connection. The low explosive intensity and location of the 2008-9 explosive activity within the heavily monitored and easily accessible summit have allowed a number of near-vent studies. Near-daily ashfall measurements have revealed temporal variations in tephra production and changes in the proportion of juveniles and lithics. Direct views of the lava surface within the vent allowed cross-correlation with seismic and geodetic signals to suggest new interpretations of tremor, infrasound, and tilt data. Near-source emission measurements allowed uniquely full characterization of gas content and associated hazards. Additional hazards posed by the summit activity include near-vent ballistic impacts and low air quality due to increased sulfur dioxide emissions. The continuing high rate emissions of SO2 directly impacted downwind communities, resulting in multiple exceedances of federal and state air quality standards for SO2 and particles on the Island of Hawai`i, agricultural losses, and long-term health concerns. The change in eruptive character for Kilauea volcano started in 2003 when line-length monitoring across the summit showed a switch from contraction, the norm since 1983, to extension. By 2004, summit carbon dioxide emissions, an indicator of magma supply, had nearly doubled. East rift zone sulfur dioxide emissions, used as a proxy for effusion rate, increased substantially in 2005. Since 2007, summit CO2 emissions have decreased and deformation has returned to deflation, both suggesting an end to the period of increased magma supply but not an end to activity. Depressurization of the magma-bloated summit may have helped to spur the largely explosive 2008-09 summit eruptive activity simultaneous with continuing east rift eruption.

Kauahikaua, J. P.; Orr, T. R.; Patrick, M. R.; Swanson, D.; Poland, M. P.; Miklius, A.; Wilson, D.; Sutton, A. J.; Elias, T.; Thornber, C. R.; Wooten, K.

2009-12-01

284

The association between EMS workplace safety culture and safety outcomes  

PubMed Central

Objective Prior studies have highlighted wide variation in EMS workplace safety culture across agencies. We sought to determine the association between EMS workplace safety culture scores and patient or provider safety outcomes. Methods We administered a cross-sectional survey to EMS workers affiliated with a convenience sample of agencies. We recruited these agencies from a national EMS management organization. We used the EMS Safety Attitudes Questionnaire (EMS-SAQ) to measure workplace safety culture and the EMS Safety Inventory (EMS-SI), a tool developed to capture self-reported safety outcomes from EMS workers. The EMS-SAQ provides reliable and valid measures of six domains: safety climate, teamwork climate, perceptions of management, perceptions of working conditions, stress recognition, and job satisfaction. A panel of medical directors, paramedics, and occupational epidemiologists developed the EMS-SI to measure self-reported injury, medical errors and adverse events, and safety-compromising behaviors. We used hierarchical linear models to evaluate the association between EMS-SAQ scores and EMS-SI safety outcome measures. Results Sixteen percent of all respondents reported experiencing an injury in the past 3 months, four of every 10 respondents reported an error or adverse event (AE), and 90% reported safety-compromising behaviors. Respondents reporting injury scored lower on 5 of the 6 domains of safety culture. Respondents reporting an error or AE scored lower for 4 of the 6 domains, while respondents reporting safety-compromising behavior had lower safety culture scores for 5 of 6 domains. Conclusions Individual EMS worker perceptions of workplace safety culture are associated with composite measures of patient and provider safety outcomes. This study is preliminary evidence of the association between safety culture and patient or provider safety outcomes. PMID:21950463

Weaver, Matthew D.; Wang, Henry E.; Fairbanks, Rollin J.; Patterson, Daniel

2012-01-01

285

QUE PAÍS É ESSE? - UMA ANÁLISE DO DILEMA ATUAL DA INDÚSTRIA FONOGRÁFICA SOB A ÓTICA DO MARKETING ESTRATÉGICO  

Microsoft Academic Search

É cada vez mais presente a discussão sobre a polêmica em torno dos direitos e interesses de gravadoras, músicos e consumidores, ou seja, a questão da autoria, divulgação, comercialização e acesso à música. De um lado, músicos sentem-se lesados por terem seus trabalhos disseminados indiscriminadamente, sem retorno financeiro adequado e, por outro, empresas de gravação e comercialização atingem volumes de

EDSON CRESCITELLI

286

Crosshole EM in steel-cased boreholes  

SciTech Connect

The application of crosshole EM methods through steel well-casing was investigated in theoretical, laboratory and field studies. A numerical code was developed that calculates the attenuation and phase delay of an EM dipole signal propagated through a steel well casing lodged in a homogeneous medium. The code was validated with a scale model and used for sensitivity studies of casing and formation properties. Finally, field measurements were made in an oil field undergoing waterflooding. Our most important findings are that (1) crosshole surveys are feasible using a well pair with one metallic and one non-metallic casing. (2) The casing effect seems be localized within the pipe section that includes the sensor. (3) The effects of the casing can be corrected using simple means and (4) crosshole field data that are sensitive to both formation and casing were acquired in a working environment.

Wilt, M.; Lee, K.H.; Becker, A.; Spies, B.; Wang, B.

1996-07-01

287

Helicopter EMS: Research Endpoints and Potential Benefits  

PubMed Central

Patients, EMS systems, and healthcare regions benefit from Helicopter EMS (HEMS) utilization. This article discusses these benefits in terms of specific endpoints utilized in research projects. The endpoint of interest, be it primary, secondary, or surrogate, is important to understand in the deployment of HEMS resources or in planning further HEMS outcomes research. The most important outcomes are those which show potential benefits to the patients, such as functional survival, pain relief, and earlier ALS care. Case reports are also important “outcomes” publications. The benefits of HEMS in the rural setting is the ability to provide timely access to Level I or Level II trauma centers and in nontrauma, interfacility transport of cardiac, stroke, and even sepsis patients. Many HEMS crews have pharmacologic and procedural capabilities that bring a different level of care to a trauma scene or small referring hospital, especially in the rural setting. Regional healthcare and EMS system's benefit from HEMS by their capability to extend the advanced level of care throughout a region, provide a “backup” for areas with limited ALS coverage, minimize transport times, make available direct transport to specialized centers, and offer flexibility of transport in overloaded hospital systems. PMID:22203905

Thomas, Stephen H.; Arthur, Annette O.

2012-01-01

288

UFPR Bacharelado em Cincia da Computao CI064 Software Bsico  

E-print Network

gerencia duas filas de caracteres, uma associada à recepção, e outra à transmissão, cada uma com capacidade fila de recepção, enquanto que ntx indica o número de espaços na fila de transmissão. O tratador de controle. A função getc() retorna o caractere que está na fila de recepção e decrementa nrx, ou EOF se

Hexsel, Roberto A

289

Time sequence spectroscopy of AW UMa. The 518 nm Mg I triplet region analyzed with Broadening Functions  

E-print Network

High resolution spectroscopic observations of AW UMa, obtained on three consecutive nights with the median time resolution of 2.1 minutes, have been analyzed using the Broadening Functions method in the spectral window of 22.75 nm around the 518 nm Mg I triplet region. Doppler images of the system reveal the presence of vigorous mass motions within the binary system. The ample evidence of a non-solid-body velocity field puts into question the contact-binary model based on solid-body equipotentials. AW UMa is a semi-detached binary; the mass transfer takes place from the more massive to the less massive component. The primary, a fast-rotating star with Vsin i = 181.4 km/s, is covered by inhomogeneities: very slowly drifting spots and a dense network of ripples more closely participating in its rotation. The spectral lines of the primary show an additional broadening component (called the "pedestal") which originates either in the equatorial regions which rotate faster than the rest of the star by about 50 km/s...

Rucinski, Slavek M

2014-01-01

290

Comparison of Observations and Analyses of 2009 and 2012 Light Curves for the Precontact W UMa Binary, V1001 Cassiopeia  

NASA Astrophysics Data System (ADS)

A 2012 follow up to the analysis of 2009 observations is presented for the very short period 0.43d) precontact WUMa Binary, V1001 Cassiopeia. Its short period, similar to the majority of W UMa’s, has a distinct EA light curve make it a very rare and interesting system for continuing photometric investigation. Previous photometric VRI standard magnitudes give a K4 spectral type (Samec 2012). Our solutions of light curves separated by some 3 years give approximately the same physical parameters. However the spots have radically changed, both temperature, area and position wise. Whereas only one dark spot was used to model the first curves, two hot spots are now needed. This affects the overall shape of the light curve, especially in the secondary eclipses in B and V. Additional eclipse timings show the orbital period is changing. We conclude that spots are very active on this solar type dwarf and that it may mimic its larger cousins, the RS CVn binaries.

Hill, Robert L.; Koenke, Samuel; Samec, Ronald G.; Faulkner, Danny R; Van Hamme, Walter V.

2014-06-01

291

Survey of Period Variations of Superhumps in SU UMa-Type Dwarf Novae. VI: The Sixth Year (2013-2014)  

E-print Network

Continuing the project described by Kato et al. (2009, PASJ, 61, S395, arXiv:0905.1757), we collected times of superhump maxima for 56 SU UMa-type dwarf novae mainly observed during the 2013-2014 season and characterized these objects. We detected negative superhumps in VW Hyi and indicated that the low number of normal outbursts in some supercycle can be interpreted as a result of the disk tilt. This finding, combined with the Kepler observation of V1504 Cyg and V344 Lyr, suggests that the disk tilt is responsible for modulating the outburst pattern in SU UMa-type dwarf novae. We also studied the deeply eclipsing WZ Sge-type dwarf nova MASTER OT J005740.99+443101.5 and found evidence of a sharp eclipse during the phase of early superhumps. The profile can be reproduced by a combination of the eclipse of the axisymmetric disk and the uneclipsed light source of early superhumps. This finding confirms the lack of evince of a greatly enhanced hot spot during the early stage of WZ Sge-type outburst. We detected g...

Kato, Taichi; Kudzej, Igor; Hambsch, Franz-Josef; Miller, Ian; Ohshima, Tomohito; Nakata, Chikako; Kawabata, Miho; Nishino, Hirochika; Masumoto, Kazunari; Mizoguchi, Sahori; Yamanaka, Masayuki; Matsumoto, Katsura; Sakai, Daisuke; Fukushima, Daiki; Matsuura, Minami; Bouno, Genki; Takenaka, Megumi; Nakagawa, Shinichi; Noguchi, Ryo; Iino, Eriko; Pickard, Roger D; Maeda, Yutaka; Henden, Arne; Kasai, Kiyoshi; Kiyota, Seiichiro; Akazawa, Hidehiko; Imamura, Kazuyoshi; de Miguel, Enrique; Maehara, Hiroyuki; Monard, Berto; Pavlenko, Elena P; Antonyuk, Kirill; Pit, Nikolaj; Antonyuk, Oksana I; Baklanov, Aleksei V; Ruiz, Javier; Richmond, Michael; Oksanen, Arto; Harlingten, Caisey; Shugarov, Sergey Yu; Chochol, Drahomir; Masi, Gianluca; Nocentini, Francesca; Schmeer, Patrick; Bolt, Greg; Nelson, Peter; Ulowetz, Joseph; Sabo, Richard; Goff, William N; Stein, William; Michel, Raul; Dvorak, Shawn; Voloshina, Irina B; Metlov, Vladimir; Katysheva, Natalia; Neustroev, Vitaly V; Sjoberg, George; Littlefield, Colin; Debski, Bartlomiej; Sowicka, Paulina; Klimaszewski, Marcin; Curylo, Malgorzata; Morelle, Etienne; Curtis, Ivan A; Iwamatsu, Hidetoshi; Butterworth, Neil D; Andreev, Maksim V; Parakhin, Nikolai; Sklyanov, Aleksandr; Shiokawa, Kazuhiko; Novak, Rudolf; Irsmambetova, Tat'yana R; Itoh, Hiroshi; Ito, Yoshiharu; Hirosawa, Kenji; Denisenko, Denis; Kochanek, Christopher S; Shappee, Benjamin; Stanek, Krzysztof Z; Prieto, Jose L; Itagaki, Koh-ichi; Stubbings, Rod; Ripero, Jose; Muyllaert, Eddy; Poyner, Gary

2014-01-01

292

Sequence analysis of two tandemly linked Em genes from wheat  

Microsoft Academic Search

DNA sequences are presented for two members of the wheat Em gene family. The sequences correspond to the two linked genes at the Xem-1AL locus. Comparisons of these sequences with that of another wheat Em gene and two Em cDNA clones reveals substantial homology within the protein-coding regions, and the presence in the 5'-flanking regions of the genomic sequences of

T. Simon Futers; Sertac Onde; Muge Turet; Andrew C. Cuming

1993-01-01

293

Photon kinetic description of 1D relativistic EM pulse solitons  

Microsoft Academic Search

Photon kinetics provides a novel formalism to describe intense EM fields-plasma interactions, where the EM fields are described as a collection of quasi-particles (photons). Photon kinetics provides a better physical picture of the EM fields dynamics, is computionally less demanding, and allows for an easy description of broadband incoherent light pulses. We have developed a 1D photon kinetic code, where

R. Trines; R. Bingham; W. B. Mori; L. O. Silva

2003-01-01

294

UNIVERSIDADE DE BRASLIA PROGRAMA DE PS-GRADUAO EM ECONOMIA  

E-print Network

UNIVERSIDADE DE BRASÍLIA PROGRAMA DE P�S-GRADUA��O EM ECONOMIA EDITAL No. 03/2012 SELE��O DE CANDIDATOS �S VAGAS DO PROGRAMA DE P�S- GRADUA��O EM ECONOMIA PARA O CURSO DE DOUTORADO ACAD�MICO PARA O PRIMEIRO SEMESTRE LETIVO DE 2013 A Coordenação do Programa de Pós-Graduação em Economia da Universidade de

Maier, Rudolf Richard

295

UNIVERSIDADE DE BRASLIA PROGRAMA DE PS-GRADUAO EM ECONOMIA  

E-print Network

1/4 UNIVERSIDADE DE BRASÍLIA PROGRAMA DE P�S-GRADUA��O EM ECONOMIA EDITAL No. 02/2011 SELE��O DE CANDIDATOS �S VAGAS DO PROGRAMA DE P�S-GRADUA��O EM ECONOMIA PARA O CURSO DE DOUTORADO PARA O PRIMEIRO PERÍODO LETIVO DE 2012 1. PRE�MBULO 1.1. O Coordenador do Programa de Pós-Graduação em Economia, no uso de

Maier, Rudolf Richard

296

UNIVERSIDADE DE BRASLIA PROGRAMA DE PS-GRADUAO EM ECONOMIA  

E-print Network

UNIVERSIDADE DE BRASÍLIA PROGRAMA DE P�S-GRADUA��O EM ECONOMIA EDITAL No. 03/2013 SELE��O DE CANDIDATOS �S VAGAS DO PROGRAMA DE P�S- GRADUA��O EM ECONOMIA PARA O CURSO DE DOUTORADO ACAD�MICO PARA O PRIMEIRO SEMESTRE LETIVO DE 2014 PRE�MBULO O Coordenador do Programa de Pós-Graduação em Economia da

Maier, Rudolf Richard

297

UNIVERSIDADE DE BRASLIA PROGRAMA DE PS-GRADUAO EM ECONOMIA  

E-print Network

UNIVERSIDADE DE BRASÍLIA PROGRAMA DE P�S-GRADUA��O EM ECONOMIA EDITAL No. 04/2011 SELE��O DE CANDIDATOS �S VAGAS DO PROGRAMA DE P�S- GRADUA��O EM ECONOMIA PARA O CURSO DE DOUTORADO ACAD�MICO PARA O PRIMEIRO SEMESTRE LETIVO DE 2012 A Coordenação do Programa de Pós-Graduação em Economia da Universidade de

Lucero, Jorge Carlos

298

UNIVERSIDADE DE BRASLIA PROGRAMA DE PS-GRADUAO EM ECONOMIA  

E-print Network

1/4 UNIVERSIDADE DE BRASÍLIA PROGRAMA DE P�S-GRADUA��O EM ECONOMIA EDITAL No. 02/2010 SELE��O DE CANDIDATOS �S VAGAS DO PROGRAMA DE P�S-GRADUA��O EM ECONOMIA PARA O CURSO DE DOUTORADO PARA O PRIMEIRO PERÍODO LETIVO DE 2011 1. PRE�MBULO 1.1. O Coordenador do Programa de Pós-Graduação em Economia, no uso de

Maier, Rudolf Richard

299

UNIVERSIDADE DE BRASLIA PROGRAMA DE PS-GRADUAO EM ECONOMIA  

E-print Network

1/3 UNIVERSIDADE DE BRASÍLIA PROGRAMA DE P�S-GRADUA��O EM ECONOMIA EDITAL No. 01/2011 SELE��O DE CANDIDATOS �S VAGAS DO PROGRAMA DE P�S-GRADUA��O EM ECONOMIA PARA O CURSO DE MESTRADO ACAD�MICO PARA O PRIMEIRO PERÍODO LETIVO DE 2012 1. PRE�MBULO 1.1. O Coordenador do Programa de Pós-Graduação em Economia

Lucero, Jorge Carlos

300

2. HI PAR (ACQUISITION RADAR) TOWER AND ENLISTED MEN (EM) ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. HI PAR (ACQUISITION RADAR) TOWER AND ENLISTED MEN (EM) BARRACKS WITH RADAR ATTACHED. - Nike Hercules Missile Battery Summit Site, Battery Control Administration & Barracks Building, Anchorage, Anchorage, AK

301

Propriedades termodinâmicas de um gás ideal em superfícies hiperbólicas compactas.  

E-print Network

??Neste trabalho investigamos algumas propriedades termodinâmicas de gases ideais em superfícies compactas de curvatura constante e negativa. Super- fícies com propriedades similares aparecem, por exemplo,… (more)

Diego de Flôor e Silva

2012-01-01

302

BUSCA LOCAL PARA POS-PROCESSAMENTO EM RESULTADOS DE OTIMIZAC~AO MULTI-OBJETIVO EM REDES DE FILAS  

E-print Network

BUSCA LOCAL PARA P´OS-PROCESSAMENTO EM RESULTADOS DE OTIMIZA¸C~AO MULTI-OBJETIVO EM REDES DE FILAS otimiza¸c~ao de redes de filas finitas, a capacidade total do sistema em ´areas de espera deve ser a menor redistribui¸c~ao de ´areas de circula¸c~ao entre as filas, preservando fixa a capacidade total do sistema. Um

Cruz, Frederico

303

HISTÓRIA, LITERATURA E DITADURA: O CASO JOÃO PAZ EM INCIDENTE EM ANTARES  

Microsoft Academic Search

This article refers to a possible critic of the Brazilian military and dictatorial regime in the 1960´s and 1970s, trough the eyes of João Paz, a character in the novel of Erico Veríssimo, Incidente em Antares . The research, from a bibliographic point of view, has been based on recent theories that relate to facts in the History and Literature

Daniela Freitas Torres; Elaine dos Santos

304

Photometry of southern stars. I - The W UMa binary SX Corvi and the RS CVn binary HD 155555  

NASA Astrophysics Data System (ADS)

Photoelectric photometry of the W UMa binary SX Corvi and of the RS CVn binary HD 155555 is presented. For SX Crv we confirm the existence of photometric changes in the light curve on consecutive nights as already observed by Sanwal et al. (1974). The variations are particularly evident during minima. A new determination of the period is performed, though there are problems with the nearly equal depths of primary and secondary minima and with the long time interval between the available epochs. For HD155555 we present for the firsttime an almost complete light curve, confirming its suspectedvariability. The light curve shape resembles that seen in other RS CVnbinaries; moreover, there are non-repetitive variations probably dueto intrinsic cycle-to-cycle changes in the system.

Scaltriti, F.; Busso, M.

1984-06-01

305

Sixty-six Year Orbital Period Study and UBV Light Curve Modeling of the W UMa Binary, TY Ursae Majoris  

NASA Astrophysics Data System (ADS)

TY UMa [SVS 366, RA(2000) = 12h 9m 2.656s, DEC(2000) = 56deg 01' 53.54"] is a W UMa binary which has been modeled in both near and shallow contact configurations (Broglia and Conconi 1983). Our recent light curves show similar attributes. However, the orbital period reveals a major and continuous change which may point to an accelerating period change over the past 36 years and possibly 66 years. Alternately, there may be a third body producing a light time amplitude of 0.124(5) days and an orbital period of 103(4) years. The present UBV observations were taken with the Lowell 0.79m reflecting telescope on April 9-11 1999. Four mean epochs of minimum light were determined from the observations made during two primary and two secondary eclipses by MLS using the bisection of chords technique. These are 2451278.8626 (2), 2451279.74951 (4), 2451279.9267 (1), 2451280.8124 (7). Recent timings yield,tangent to the curve, the following linear ephemeris: J.D. Hel Min I = 2450193.5726(46) d + 0. 35454228 (22) X E. Simultaneous, Wilson Code UBV light curve synthesis models are presented. MLS performed much of the analysis in her undergraduate research project. RGS and DRF were visiting Astronomers at Lowell Observatory, Flagstaff, Arizona This research was partially supported by a grant from NASA administered by the American Astronomical Society. References: Broglia, P., Conconi, P. 1981, A&AP 51, 97b

Samec, R. G.; Stoddard, M. L.; Faulkner, D. R.

2000-05-01

306

10 CFR Appendixes E-M to Part 52 - [Reserved  

10 Energy 2 2014-01-01 2014-01-01 false [Reserved] E Appendixes E-M to Part 52 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS Appendixes E-M to Part 52...

2014-01-01

307

Under Review Scaling Down EM Using Graph Based  

E-print Network

a probabilistic model formulation characterized by the parameters of the probability distribution. For example, in the above applications [3, 17] a #12;Scaling Down EM Using Graph Based Models 3 Gaussian distributionUnder Review Scaling Down EM Using Graph Based Models Ian Davidson Department of Computer Science

Davidson, Ian

308

Stochastic EM-based TFBS motif discovery with MITSU  

PubMed Central

Motivation: The Expectation–Maximization (EM) algorithm has been successfully applied to the problem of transcription factor binding site (TFBS) motif discovery and underlies the most widely used motif discovery algorithms. In the wider field of probabilistic modelling, the stochastic EM (sEM) algorithm has been used to overcome some of the limitations of the EM algorithm; however, the application of sEM to motif discovery has not been fully explored. Results: We present MITSU (Motif discovery by ITerative Sampling and Updating), a novel algorithm for motif discovery, which combines sEM with an improved approximation to the likelihood function, which is unconstrained with regard to the distribution of motif occurrences within the input dataset. The algorithm is evaluated quantitatively on realistic synthetic data and several collections of characterized prokaryotic TFBS motifs and shown to outperform EM and an alternative sEM-based algorithm, particularly in terms of site-level positive predictive value. Availability and implementation: Java executable available for download at http://www.sourceforge.net/p/mitsu-motif/, supported on Linux/OS X. Contact: a.m.kilpatrick@sms.ed.ac.uk PMID:24931999

Kilpatrick, Alastair M.; Ward, Bruce; Aitken, Stuart

2014-01-01

309

Processamento auditivo e SPECT em crianças com dislexia  

Microsoft Academic Search

RESUMO - Aplicamos em um grupo de 36 crianças os testes dicótico de dígitos, dicótico de dissílabos altern a- dos e dicótico não-verbal, os quais fazem parte do conjunto de avaliação do processamento auditivo. As crianças foram divididas em dois grupos que foram correlacionados: grupo experimental (GE) formado por 18 crianças com diagnóstico de dislexia e 18 crianças normais compondo

Luciane Sauer; Liliane Desgualdo Pereira; Sylvia Maria Ciasca; Magda Pestun; Marilisa M. Guerreiro

2006-01-01

310

Standard Errors for EM Estimates in Generalized Linear Models with  

E-print Network

. As additional covariate among others the temperature was recorded. The bacteria content was determinedStandard Errors for EM Estimates in Generalized Linear Models with Random Effects Herwig Friedl of EM estimates in generalized linear models with random effects. Quadrature formulae are used

Friedl, Herwig

311

A Double Layer Electromagnetic Cloak And GL EM Modeling  

E-print Network

In this paper, we propose a novel electromagnetic (EM) cloaking structure that consists of two annular layers between three spherical shells and model its performance numerically and theoretically by using a Global and Local EM field (GL) method. The two annular layers contain distinct cloaking materials: the outer layer provides invisibility; the inner layer is fully absorbing. The cloaking materials are weakly degenerative. The wavefield from an EM source located outside the cloak propagates as in free space outside the outer shell, never be disturbed by the cloak and does not penetrate into the inner absorbing layer and concealment. The field of a source located inside inner layer or the cloaked concealment is completely absorbed by the inner layer and never reaches the outside of the middle shell, Moreover, the EM wavefield excited in concealment is not disrupted by the cloak. There exists no Maxwell EM wavefield can be excited in a single layer cloaked concealment which is filled by normal material. More...

Xie, Ganquan; Xie, Feng; Xie, Lee

2009-01-01

312

Análise comparativa da expressão de citoqueratinas, involucrina, filagrina e e-caderina em verrugas planas e em lesões do tipo verruga plana na Epidermodisplasia Verruciforme.  

E-print Network

??Epidermodisplasia verruciforme (EV) é uma genodermatose rara, com susceptibilidade para infecção pelo vírus do papiloma humano, considerada modelo de oncogênese viral. Comparou-se a expressão epidérmica… (more)

Andrezza Camarinha Napolitano Barcelos

2008-01-01

313

Electromagnetic optimization of EMS-MAGLEV systems  

SciTech Connect

In EMS-MAGLEV high-speed transport systems, devices for propulsion, levitation and contactless on-board electric power transfer are combined in a single electromagnetic structure. The strong coupling among the windings affects the performance of each device and requires the utilization of numerical codes. The paper describes an overall optimization procedure, based on a suitable mathematical model of the system, which takes into account several items of the system performance. The parameters of the model are calculated by an automated sequence of FEM analyses of the configuration. Both the linear generator output characteristics and the propulsion force ripple are improved applying the procedure to a reference configuration. The results are compared with the results obtained by a sequence of partial optimizations operating separately on two different subsets of the geometric parameters.

Andriollo, M.; Martinelli, G.; Morini, A.; Tortella, A. [Univ. of Padova (Italy). Dept. of Electrical Engineering] [Univ. of Padova (Italy). Dept. of Electrical Engineering

1998-07-01

314

DOE EM industry programs robotics development  

SciTech Connect

The Office of Science and Technology (OST) manages an aggressive program for RD&D, as well as testing and evaluation for the U.S. Department of Energy`s (DOE) Environmental Management (EM) organization. The goal is to develop new and improved environmental restoration and waste management technologies to clean up the inventory of the DOE weapons complex faster, safer, and cheaper than is possible with currently available technologies. OST has organized technology management activities along focus teams for each major problem area. There are currently five focus areas: decontamination and decommissioning, tanks, subsurface contaminants, mixed waste, and plutonium. In addition, OST is pursuing research and development (R&D) that cuts across these focus areas by having applications in two or more focus areas. Currently, there are three cross-cutting programs: the robotics technology development; characterization, monitoring, and sensor technologies; and efficient separations and processing.

Staubly, R.; Kothari, V. [Dept. of Energy, Morgantown, WV (United States)

1997-12-01

315

Evaluation of Fracture Azimuth by EM Wave and Elastic Wave  

NASA Astrophysics Data System (ADS)

Fracture system plays an important role in the development of underground energy, for example enhanced geothermal system (EGS), oil shale and shale gas, etc. Therefore, it becomes more and more important to detect and evaluate the fracture system. Geophysical prospecting is an useful method to evaluate the characteristics of the subsurface fractures. Currently, micro-seismology, multi-wave seismic exploration, and electromagnetic (EM) survey are reported to be used for the purpose. We are studying a method using both elastic wave and EM wave to detect and evaluate the fracture azimuth in laboratory. First, we build a 3D horizontal transverse isotropy (HTI) model, shown in the figure 1, by dry parallel fractures system, which was constructed by plexiglass plates and papers. Then, we used the ultrasonic system to obtain reflected S-wave data. Depending on the shear wave splitting, we evaluated the fracture azimuth by the algorithm of Pearson correlation coefficient. In addition, we used the full Polarimetric ultra wide band electromagnetic (FP-UWB-EM) wave System, shown in the figure 2, to obtain full polarimetric reflected EM-wave data. Depending on the rotation of the EM wave polarimetry, we evaluated the fracture azimuth by the the ration between maximum amplitude of co-polarimetric EM wave and maximum amplitude of cross-polarimetric EM wave. Finally, we used both EM-wave data and S-wave data to evaluate the fracture azimuth by the method of cross plot and statistical mathematics. To sum up, we found that FP-UWB-EM wave can be used to evaluated the fracture azimuth and is more accurate than ultrasound wave. Also joint evaluation using both data could improve the precision.

Feng, X.; Wang, Q.; Liu, C.; Lu, Q.; Zeng, Z.; Liang, W.; Yu, Y.; Ren, Q.

2013-12-01

316

Sensitive Search for Water Maser Emission from the Eps Eri, Ups And, and 47 UMa Systems with the VLA  

NASA Astrophysics Data System (ADS)

Following recent reports of the detection of water maser mission from a number of extra-solar planetary systems [1] we have used the Very Large Array [2] to perform a sensitive search for 22 GHz water line emission toward Epsilon Eridani, Upsilon Andromedae, and 47 Ursa Majoris. The observations were made on 2002 September 24 (Eps Eri) and 29 (Ups And), and October 8 (Ups And), 10 (Eps Eri), and 11 (47 UMa). The September observations had spectral resolution of 98 kHz (1.3 km/s) over a total width of 6.25 MHz (84 km/s). In the October observations, in order to cover a wider total velocity range, the channel width was increased by a factor of 2 to 196 kHz (2.6 km/s) over a total width of 12.5 MHz (168 km/s). Our results are uniformly negative -- no H2O emission was detected from any of the three stars, with 3-? upper limits of 5.7 & 2.6, 10.2 & 2.5, and 2.9 mJy/beam/channel for Eps Eri, Ups And, and 47 UMa respectively. This is consistent with other recent observations which detected no water line emission from these systems [3]. Our sensitivity is such that we should have easily been able to detect the lines previously reported [4]. We therefore conclude either that water maser emission is time variable, or that the previous measurements were in error. Future coordinated observations between observatories and groups should be undertaken to address this issue. [1] C. Cosmovici et al., First detection of water in extra-solar planets: A new step in astrobiology, presented at: Second European Workshop on Exo/Astrobiology, Graz, Austria, September 2002 [2] The Very Large Array is operated by National Radio Astronomy Observatory, which is a facility of the National Science Foundation operated under cooperative agreement by Associated Universities, Inc. [3] Greenhill et al., IAU Circular 7985 [4] C. Cosmovici, personal communication.

Butler, B. J.; Chandler, C. J.; Claussen, M. J.; Greenhill, L. J.

2002-12-01

317

Ultraviolet spectral behavior of IP Peg and DW UMa in high, intermediate and low states from the HST and IUE satellites  

NASA Astrophysics Data System (ADS)

Ultraviolet spectra of IP Peg and DW UMa observed with Hubble Space Telescope Space Telescope Imaging Spectrograph & Faint Object Spectrograph (HST STIS FOS) and International Ultraviolet Explorer (IUE) satellites were analyzed during the period between 1989-1994 and 1985-2004. Different profiles of two systems showing variations of line fluxes at different orbital phases are presented. Both IP Peg and DW UMa are characterized by emission lines in high, intermediate and low states. DW UMa is characterized by absorption lines in an unusual low state. This paper focuses on the C IV emission line at 1550 Å produced in an accretion disk for two systems (Saito et al., 2005; Knigge et al., 2000), by calculating spectral line fluxes. Our results show that there are significant variations of line fluxes with time for two systems. The variations of line fluxes are attributed to the variations of both density and temperature as a result of a changing rate of mass transfer from the secondary star to the white dwarf (Saito et al., 2005; Knigge et al., 2000). These results from the IUE and HST observations support a white dwarf model atmospheres of IP Peg and DW UMa producing sufficient UV flux for orbital modulations.

Sanad, M. R.

2014-02-01

318

ESTIMATIVAS DA AREA DE ATRAC~AO DE SISTEMAS N~AO LINEARES COM INCERTEZAS VARIANTES NO TEMPO POR MEIO DE UMA CLASSE DE  

E-print Network

on the mean value theorem in conjunction to an approximation technique of convex sets to obtain this LDI differential inclusions, linear matrix inequalities Resumo-- Este artigo prop~oe utilizar uma classe particular forma de inclus~oes diferenciais lineares ou LDIs (do ingl^es, linear differential in- clusions), sendo

Pota, Himanshu Roy

319

Optimization of ultrasonic/microwave assisted extraction (UMAE) of polysaccharides from Inonotus obliquus and evaluation of its anti-tumor activities.  

PubMed

Recently, the use of ultrasonic and microwave has attracted considerable interest as an alternative approach to the traditional extraction methods. In this paper, in order to maximize the yield and purity of polysaccharides from Inonotus obliquus, response surface methodology (RSM) was employed to optimize the ultrasonic/microwave assisted extraction (UMAE) conditions. The results indicated that the optimal conditions for UMAE were 90W microwave power, 50W ultrasonic power together with 40kHz ultrasonic frequency, solid/water ratio was 1:20 (W/V) and the extracting time was 19min, respectively. Under the optimal conditions, the yield and purity of polysaccharides were 3.25% and 73.16%, respectively, which are above that of traditional hot water extraction and close to the predicted value (3.07% and 72.54%, respectively). These results confirmed that ultrasonic/microwave assisted extraction (UMAE) of polysaccharides had great potential and efficiency compared with traditional hot water extraction. At the same time, the anti-tumor activities of the polysaccharides from I. obliquus with UMAE were evaluated. The results suggested that polysaccharides from I. obliquus exhibited obvious anti-tumor activities. PMID:20149817

Chen, Yiyong; Gu, Xiaohong; Huang, Sheng-quan; Li, Jinwei; Wang, Xin; Tang, Jian

2010-05-01

320

CONCRETO DE ALTO DESEMPENHO EM AMBIENTES COM BAIXAS TEMPERATURAS  

Microsoft Academic Search

Resumo Propondo-se o concreto como alternativa construtiva de estruturas destinadas a guarda e conservação de alimentos como parte da solução das questões relacionadas à preservação e viabilidade do crescimento da população mundial, não obstante dos conceitos de uma engenharia sustentável, onde a durabilidade torna-se sine qua non e, por meio dos métodos de dosagem desenvolvidos pelos pesquisadores do LMABC (Laboratório

Sandra Maria de Lima; Jefferson Benedicto; Libardi Libório

2008-01-01

321

ISSN 0103-9741 Monografias em Cincia da Computao  

E-print Network

que líderes acadêmi- cos devem tratar a necessidade de uma maior diversidade no corpo docente e no perfil de alunos de seus programas acadêmicos para reverter o declínio da procura pela área. Jovens com

Endler, Markus

322

Prognóstico audiológico tardio relacionado à meningite em lactentes  

Microsoft Academic Search

RESUMO - Introdução: Déficit auditivo tem sido considerado uma das principais manifestações tardias das meningites, sobretudo quando esta ocorre nos dois primeiros anos de vida. No país, poucos são os estudos relatando a evolução de crianças acometidas por meningite e a percentagem e gravidade dos transtornos auditivos e seqüelas neurológicas após a alta hospitalar. Objetivo: Caracterizar as principais seqüelas auditivas

Luzia Poliana Anjos; Fernanda Queirós; Maria Cecília Pereira; Marcela Brandão; Ailton Melo; Rita Lucena

2004-01-01

323

Cultivo hidropônico de lisianto p ara flor de corte em sistema de fluxo laminar de nutrientes  

Microsoft Academic Search

Resumo - O objetivo deste trabalho foi avaliar as características produtivas e comerciais do cultivo de quatro cultivares de lisianto (Eustoma grandiflorum) em três soluções nutritivas em sistema de fluxo laminar de nutrientes (NFT). Utilizou-se o delineamento em blocos casualizados, em esquema fatorial 4x3, com três repetições. Os tratamentos foram compostos de quatro cultivares (Echo Champagne, Mariachi Pure White, Balboa

Alice Antonello; Londero Backes; José Geraldo Barbosa; Paulo Roberto Cecon; José Antonio Saraiva Grossi; Rogério Luiz Backes; Fernando Luiz Finger; Av. P. H. Rolfs

324

Speciation, population structure, and demographic history of the Mojave Fringe-toed Lizard (Uma scoparia), a species of conservation concern  

PubMed Central

The North American deserts were impacted by both Neogene plate tectonics and Quaternary climatic fluctuations, yet it remains unclear how these events influenced speciation in this region. We tested published hypotheses regarding the timing and mode of speciation, population structure, and demographic history of the Mojave Fringe-toed Lizard (Uma scoparia), a sand dune specialist endemic to the Mojave Desert of California and Arizona. We sampled 109 individual lizards representing 22 insular dune localities, obtained DNA sequences for 14 nuclear loci, and found that U. scoparia has low genetic diversity relative to the U. notata species complex, comparable to that of chimpanzees and southern elephant seals. Analyses of genotypes using Bayesian clustering algorithms did not identify discrete populations within U. scoparia. Using isolation-with-migration (IM) models and a novel coalescent-based hypothesis testing approach, we estimated that U. scoparia diverged from U. notata in the Pleistocene epoch. The likelihood ratio test and the Akaike Information Criterion consistently rejected nested speciation models that included parameters for migration and population growth of U. scoparia. We reject the Neogene vicariance hypothesis for the speciation of U. scoparia and define this species as a single evolutionarily significant unit for conservation purposes. PMID:25360285

Gottscho, Andrew D; Marks, Sharyn B; Jennings, W Bryan

2014-01-01

325

Tephra deposits of impulsive explosive events during the 2008 eruption of Halema`uma`u Crater, Kilauea  

NASA Astrophysics Data System (ADS)

Eight short-lived impulsive explosive eruptions of low intensity occurred at Halema`uma`u crater, Kilauea in March-October 2008. Estimated total erupted masses were 10E+5 to 10E+6 kg; using inferred durations of 20-50 s, these equate to eruption rates of c. 10E+3 to 10E+4 kg/s, an order of magnitude lower than typical sustained Hawaiian fountains of the 20th century. Deposits are predominantly lapilli-sized but generally contain two elements: near-circular aprons of ballistic blocks extending to 200-400 m from the vent and wind-attenuated convective fall lobes which extend several tens of kilometers downwind but barely reach single-clast thickness even along the dispersal axes. Thinning half-distances (bt) for the deposits are 10-90 m, consistent with the exceptionally low mass discharges and similar to those of mild Strombolian eruptions. This geometry is essentially cone-like (and consistent with the low discharge rates) but the short duration of the events means no permanent deposit has formed. The deposits are relatively well-sorted yet richer in wall rock than the products of typical Hawaiian or Strombolian explosions.

Houghton, B. F.; Swanson, D.; Carey, R. J.; Rausch, J.

2010-12-01

326

Long Period Monitoring of the Superoutbursts of Two SU UMa-type Dwarf Nova Stars: FO And and IR Gem  

NASA Astrophysics Data System (ADS)

Analysis of long-term observations for two SU UMa-type dwarf nova stars, FO And and IR Gem, are presented. Observations for FO And were obtained yearly from 1991 to 2005 and for IR Gem from 1991 to 2003 using Roboscope located at Indiana University. The long baseline has shown long term variation in both stars with a preliminary period of ~6000 +/-1000 days for FO And. A preliminary measurement for the nominal time between superoutbursts has been determined to be a minimum of ~80 days for FO And with an amplitude of ~3.2 mag above the quiescent magnitude. For IR Gem a minimum spacing of ~25 days with an amplitude of 3.4 mag above the quiescent magnitude is found. It is also observed that the maximum magnitudes during superoutbursts are relatively constant despite the variation in the quiescent magnitude. The time between normal outbursts for FO And and IR Gem are minimum of ~4 days and ~10 days respectively. FWHM values for both normal and superoutbursts as well as superoutburst decline rates are presented.

Maxwell, Aubrie A.; Honeycutt, R. K.

2013-06-01

327

Speciation, population structure, and demographic history of the Mojave Fringe-toed Lizard (Uma scoparia), a species of conservation concern.  

PubMed

The North American deserts were impacted by both Neogene plate tectonics and Quaternary climatic fluctuations, yet it remains unclear how these events influenced speciation in this region. We tested published hypotheses regarding the timing and mode of speciation, population structure, and demographic history of the Mojave Fringe-toed Lizard (Uma scoparia), a sand dune specialist endemic to the Mojave Desert of California and Arizona. We sampled 109 individual lizards representing 22 insular dune localities, obtained DNA sequences for 14 nuclear loci, and found that U. scoparia has low genetic diversity relative to the U. notata species complex, comparable to that of chimpanzees and southern elephant seals. Analyses of genotypes using Bayesian clustering algorithms did not identify discrete populations within U. scoparia. Using isolation-with-migration (IM) models and a novel coalescent-based hypothesis testing approach, we estimated that U. scoparia diverged from U. notata in the Pleistocene epoch. The likelihood ratio test and the Akaike Information Criterion consistently rejected nested speciation models that included parameters for migration and population growth of U. scoparia. We reject the Neogene vicariance hypothesis for the speciation of U. scoparia and define this species as a single evolutionarily significant unit for conservation purposes. PMID:25360285

Gottscho, Andrew D; Marks, Sharyn B; Jennings, W Bryan

2014-06-01

328

EM 9043 October 2011 Growing Farms: Successful Whole  

E-print Network

of the Oregon State University Extension Service Small Farms Program (http://smallfarms.oregonstate.edu) #12 ................................................................5 SWOT Analysis...............................................................7 Resource InventoryEM 9043 · October 2011 Growing Farms: Successful Whole Farm Management Planning Book Think It

Tullos, Desiree

329

Genética de populações e relações de parentesco em Ciconiiformes (Aves).  

E-print Network

??Estudos de genética de populações e de parentesco genético foram desenvolvidos em colhereiro (Platalea ajaja), cabeça-seca (Mycteria americana) e garça-branca-grande (Ardea alba egretta), de colônias… (more)

Carolina Isabel Miño

2010-01-01

330

Structure of Matter, Forces, EM Waves, Spectroscopy, Doppler Effect  

NSDL National Science Digital Library

These supplemental class notes cover the basic properties of matter, the nature of forces, the electromagnetic spectrum, and how astronomers exploit the properties of the EM spectrum to deduce the physical nature of distant objects.

O'Connell, Robert

2005-06-28

331

An Innovative Tool to Assist in Rural EMS Response  

E-print Network

technologies for EMS -NextGeneration 911 -IP telephony -AACN -Mobile phones -Computer Aided Dispatch (CAD) -GPS (security & privacy) !Users must want to use it, be able to use it, like to use it !Leverage growth

Minnesota, University of

332

An Effective EMS Hardware and Software Interface- The Trained Operator  

E-print Network

you have es tablished operator training objectives, selecting appropriate training methods becomes easier. OPERATOR SKILL CATEGORIES Identifying and defining your EMS instructional objectives can be a fairly straightforward process. There is a... ings are minimal. An operator needs the full capability of being able to address all the EMS features and related individ ual building functions. Can you see the results of having a fully trained operator? Less personal frustration, improved use...

Cherry, C. L.

333

EM clustering analysis of diabetes patients basic diagnosis index.  

PubMed

Cluster analysis can group similar instances into same group and different instances into different groups. It assigns classes to samples without known the classes in advance. EM clustering algorithm can find number of distributions of generating data and build "mixture models". It identifies groups that are either overlapping or varying sizes and shapes. In this project, by using EM in Weka system, diabetes patient basic diagnosis index data have been analyzed for clustering. PMID:16779444

Wu, Cai; Steinbauer, Jeffrey R; Kuo, Grace M

2005-01-01

334

EM algorithm estimation of TCM scheme over multipath fading  

E-print Network

estimate is available to the receiver. B. Previous Research The following are some studies in application of EM algorithm in a, communicat, ion problem. Han and Georghiades [I] investigated the application of EM algorithm to t, he optimum receiver... 4. In Sections A and C, the structure of encoder an&i decoder implemented in the simulation is described. We described how the fading model is simulated in Section B. A. Transmitter A transmitter used in this study employs Ungerboeck's 8-state...

Gunawan, Wiedy

2012-06-07

335

Users of midwest EMS firm stuck without software  

SciTech Connect

Four midwest energy management system (EMS) users report delays in software delivery and a failure to achieve energy savings with National Control Systems Inc. (NCS) equipment. A fifth user has already replaced an unsatisfactory NCS system. Representatives of the users relate their experiences in trying to make the EMS systems works and to acquire the necessary software beyond the original start/stop functions. Most expect to deal with larger, more established companies in the future. (DCK)

Galvin, C.

1983-07-18

336

NASA EM Followup of LIGO-Virgo Candidate Events  

NASA Technical Reports Server (NTRS)

We present a strategy for a follow-up of LIGO-Virgo candidate events using offline survey data from several NASA high-energy photon instruments aboard RXTE, Swift, and Fermi. Time and sky-location information provided by the GW trigger allows for a targeted search for prompt and afterglow EM signals. In doing so, we expect to be sensitive to signals which are too weak to be publicly reported as astrophysical EM events.

Blackburn, Lindy L.

2011-01-01

337

Efeito Agudo de uma Sessão de Hidroginástica sobre a Resposta da Pressão Arterial em Gestantes não Hipertensas Acute Effect of an Aquagym Session on Blood Pressure Response in Non-Hypertensive Pregnant Women  

Microsoft Academic Search

Background: There are few studies analyzing acute cardiovascular response after exercise during pregnancy. Objective: To measure blood pressure response in non- hypertensive pregnant women after an aqua-gym session. Methods: The sample consisted of eight non-hypertensive and physically active pregnant women (21-36 weeks). Experimental (EXP) and Control (CON) data were collected on two days, with blood pressure was measured by auscultation.

Bethânia Tamara Coelho; Marcos Doederlein Polito

338

Digestive adaptation: A new surgical proposal to treat obesity based on physiology and evolution Adaptação digestiva: Uma nova proposta cirúrgica para tratar a obesidade com base em fisiologia e evolução  

Microsoft Academic Search

Objective: To report on a new surgical technique to treat obesity - Digestive Adaptation - and to present its preliminary results. Method: The technique includes a vertical (sleeve) gastrectomy, omentectomy and enterectomy maintaining the initial 150-cm- portion of the jejunum and the final 150-cm-portion of the ileum. The three first obese patients operated on are described. Results: With a minimum

Sérgio Santoro; Manoel Carlos; Prieto Velhote; Carlos Eduardo Malzoni; Alexandre Sérgio Gracia Mechenas; Victor Strassmann; Morton Scheinberg

339

A teoria, o livro didático e o professor: uma análise da implementação de tarefas orais em LE (The theory, the textbook and the teacher: an analysis of the implementation of oral tasks in foreign language teaching)  

Microsoft Academic Search

3 ABSTRACT: This paper investigates how EFL oral activities are implemented in the classroom and focuses on the relationship between pedagogical theory, the textbook, and the teacher. Data were collected through classroom observation and an interview with the participant teacher. The qualitative analysis of results indicates that speaking is not treated in its own right and is used as a

Raquel Carolina; Souza Ferraz; Mailce Borges MOTA

340

Efeitos da prática mental combinada à cinesioterapia em pacientes pós-acidente vascular encefálico: uma revisão sistemática Effects of mental practice combined with kinesiotherapy in post stroke patients: a systematic review  

Microsoft Academic Search

SUMMARY Introduction. Mental practice (MP) consists of mental simulation of repetitive movements with the intention of promoting the learning of a motor ability. Objective. To investigate if MP, when combined to kine- siotherapy, is efficient in the motor deficit recovery in upper limbs of post stroke patients. Method. We realized Systematic Review throughout Data Bases PubMed\\/Medline, Cochrane Database of Systematic

Mariana Pacheco; Sergio Machado; José Eduardo Lattari; Cláudio Elidio Portella; Bruna Velasques; Julio Guilherme Silva; Victor Hugo Bastos; Pedro Ribeiro

341

Comorbid eating disorders in a Brazilian Attention Deficit\\/Hyperactivity Disorder adult clinical sample Transtornos alimentares comórbidos em uma amostra clínica de adultos com transtorno do déficit de atenção com hiperatividade  

Microsoft Academic Search

a Study Group on Attention Disorder, Institute of Psychiatry of the Federal University of Rio de Janeiro b Institute of Mental Health Studies - Federal University of Rio de Janeiro c Group on Obesity Disorders and Eating Disorders, State Institute on Diabetes and Endocrinology Abstract Abstract Abstract Abstract Abstract Although comorbidity between attention-deficit\\/hyperactivity disorder (ADHD) and eating disorders (ED) is

Paulo Mattos; Eloisa Saboya; Vanessa Ayrão; Daniel Segenreich; Monica Duchesne; Gabriel Coutinho

2004-01-01

342

DOE EM industry programs robotics development  

SciTech Connect

The Office of Science and Technology (OST) manages an aggressive program for RD and D, as well as testing and evaluation for the Department of Energy`s (DOE`s) Environmental Management (EM) organization. The goal is to develop new and improved environmental restoration and waste management technologies to clean up the inventory of the DOE weapons complex faster, safer, and cheaper than is possible with currently available technologies. Robotic systems reduce worker exposure to the absolute minimum, while providing proven, cost-effective, and, for some applications, the only acceptable technique for addressing challenging problems. Development of robotic systems for remote operations occurs in three main categories: tank waste characterization and retrieval; decontamination and dismantlement; and characterization, mapping, and inspection systems. In addition, the Federal Energy Technology Center (FETC) has some other projects which fall under the heading of supporting R and D. The central objective of all FETC robotic projects is to make robotic systems more attractive by reducing costs and health risks associated with the deployment of robotic technologies in the cleanup of the nuclear weapons complex. This will be accomplished through development of robots that are cheaper, faster, safer, and more reliable, as well as more straightforward to modify/adapt and more intuitive to operate with autonomous capabilities and intelligent controls that prevent accidents and optimize task execution.

Staubly, R.; Kothari, V.

1998-12-31

343

EM Task 9 - Centrifugal Membrane Filtration  

SciTech Connect

This project is designed to establish the utility of a novel centrifugal membrane filtration technology for the remediation of liquid mixed waste streams at US Department of Energy (DOE) facilities in support of the DOE Environmental Management (EM) program. The Energy and Environmental Research Center (EERC) has teamed with SpinTek Membrane Systems, Inc., a small business and owner of the novel centrifugal membrane filtration technology, to establish the applicability of the technology to DOE site remediation and the commercial viability of the technology for liquid mixed waste stream remediation. The technology is a uniquely configured process that makes use of ultrafiltration and centrifugal force to separate suspended and dissolved solids from liquid waste streams, producing a filtered water stream and a low-volume contaminated concentrate stream. This technology has the potential for effective and efficient waste volume minimization, the treatment of liquid tank wastes, the remediation of contaminated groundwater plumes, and the treatment of secondary liquid waste streams from other remediation processes, as well as the liquid waste stream generated during decontamination and decommissioning activities.

Stevens, B.G.; Stepan, D.J.; Hetland, M.D.

1998-11-01

344

Isolamento de Salmonella spp. em pombos (Columba livia) no Distrito Federal : aspecto de relevância ao sistema de vigilância em saúde.  

E-print Network

??Dissertação (mestrado)—Universidade de Brasília, Faculdade de Agronomia e Medicina Veterinária, Programa de Pós-Graduação em Saúde Animal, 2014. A domesticação de pombos da espécie Columba livia,… (more)

Santos, Ivanildo de Oliveira Correia

2014-01-01

345

Condensação de Bose-Einstein para um gás de bósons não interagentes em confinamentos bidimensionais em automatos celulares complexos.  

E-print Network

??Neste trabalho estudamos as propriedades termodinâmicas da Condensação de Bose-Einstein (CBE) para um gás de bósons não-interagentes confinado em potenciais bidimensionais V(x,y) que apresentam classicamente,… (more)

Daniel Schardosim Calovi

2007-01-01

346

Identificação de um gene que afeta a produção de ocratoxina A em Aspergillus carbonarius.  

E-print Network

??A ocratoxina A é uma micotoxina produzida principalmente por espécies pertencentes aos gêneros Aspergillus e Penicillium, conhecida por apresentar efeitos nefrotóxicos e potencial carcinogênico. Com… (more)

Lígia Uno Lunardi

2009-01-01

347

Photometric study and preliminary elements of the low-mass ratio W UMa system ASAS 021209+2708.3  

NASA Astrophysics Data System (ADS)

We present CCD B and V light curves, obtained in the year 2006, and a photometric solution of the low-mass ratio contact binary ASAS 021209+2708.3. With our data we were able to determine six new times of minimum light and refine the orbital period of the system to 0.3181963 days. The light curves are analyzed using the 2003 version of the Wilson-Devinney program and the analysis was performed with and without adding a spot on the surface of one star because the light curves appear to exhibit a typical O'Connell effect, with Maximum I brighter than Maximum II. The results show that ASAS 021209+2708.3 may be classified as an A-subtype W Ursae Majoris system with a small mass ratio q = 0.1889, a large over-contact degree of f = 0.587, a very small difference between the component temperatures of ?T = 53 K and an orbital inclination of i = 81°. It is known that deep (f > 50%), low-mass ratio (q < 0.25) overcontact binary stars are a very important resource for understanding the phenomena of Blue Straggler/FK Com-type stars. The formations of Blue Straggler stars and FK Com-type stars are unsolved problems in stellar astrophysics. One of the possible explanations for their formation is from the coalescence of W UMa-type overcontact binary systems. The absolute dimensions of ASAS 021209+2708.3 are estimated and its dynamical evolution is inferred.

Acerbi, Francesco; Barani, Carlo; Martignoni, Massimiliano

2011-07-01

348

STF mantm cobrana de taxa para inscrio em vestibular A Procuradoria-Geral Federal em atuao conjunta com a Procuradoria Regional  

E-print Network

STF mantém cobrança de taxa para inscrição em vestibular A Procuradoria-Geral Federal em atuação sustentava a constitucionalidade da cobrança da taxa de vestibular. Ao apreciar o caso, a Ministra Ellen a de inscrição em vestibular. Fonte: STF #12;

Floeter, Sergio Ricardo

349

Percepção Astronômica de um Grupo de Alunos do Ensino Médio de uma Escola da Rede Estadual de São Paulo  

NASA Astrophysics Data System (ADS)

Being the Astronomy one of the oldest sciences of the humanity, and considering its historical and cultural importance, it is of extreme relevance that topics related to it are taught and studied at schools. Although the National Curriculum Parameters of the Senior High School (PCN-EM) and the Complementary Orientations to the Parameters (PCN+) indicate the importance of a significant approach of concepts related to the Astronomy in the Physics classes, many students finish the Senior High School (EM) without understanding the reason of certain events of celestial origin, although these are part of their daily lives and are a subject of natural curiosity for the youngsters. From the perception of the natural curiosity of the students of a São Paulo's Public School in the city of Suzano, came up the interest to investigate the basic knowledge in Astronomy of the Senior High School students at this school, becoming this the main goal of this research. A questionnaire of multiple choices was elaborated and initially applied to 34 students of the first grade and later, to more 310 students. It was distributed among the three grades of the Senior High School in the morning and night periods. In the way, it was observed that 73.9% of the students identified the Sun as a star, 67.1% demonstrated to understand the succession between the day and the night and 52.3% related the Big Bang to the origin of the Universe. In compensation, only 34.5% related the seasons of the year to the inclination of the rotation axis of the Earth, 21.3% indicated the simultaneous gravitational influence of the Moon and the Sun as responsible for the tides phenomenon, 24.5% correctly indicated which are the closest celestial objects to the Earth, 36.1% identified the light-year as a distance measure and only 34.2% recognized the shooting stars as meteors, being evidenced the small discernment of the students about the phenomena and astronomical terms of the daily life. Besides, the answers of different grade students and periods were compared, being observed, among other things, that the third grade students present a percentile of correct answers similar to the performance of the first grade students, demonstrating that the approach of topics related to the astronomy in the Senior High School has not been contributing in a significant way to a better understanding of the phenomena and the concepts.

de Oliveira, E. F.

2007-06-01

350

Acumulação de nutrientes em mudas de moringa ( Moringa oleifera Lam) sob omissão de macronutrientes1  

Microsoft Academic Search

Resumo - A Moringa oleifera Lam. é uma espécie arbórea pertencente à família Moringaceae, adaptada às condi- ções áridas e semi-áridas e de uso diversificado com especial destaque na ornamentação de parques e jardins, na alimentação animal, na complementação alimentar humana e na medicina. Uma vez que são poucas as informações sobre essa planta, o trabalho teve como objetivo avaliar

Hugo Vieira; Lucia Helena; Garófalo Chaves; Ricardo Almeida Viégas

2008-01-01

351

Livro de actividades em ToonTalk para o pré-escolar  

Microsoft Academic Search

Como orientação para os educadores, foi desenvolvido um conjunto de actividades adequadas a contextos de educação pré-escolar (crianças dos 3 aos 5 anos, na presença de educadores), que se apoiam no videojogo - ou videobrinquedo - ToonTalk. Para permitir uma fácil compreensão e acompanhamento por parte de crianças e educadores, foi então desenvolvida uma forma gráfica de transmitir essas actividades,

Leonel Morgado; Maria Gabriel Bulas Cruz; Ana Teresa Tavares; Christophe Moura

352

Propulsion From a Rotating EM Tether at Jupiter  

NASA Technical Reports Server (NTRS)

The Jovian system with its rapid planetary rotation and strong magnetic field presents exciting opportunities for the use of electrodynamic (EM) tethers. Previous analysis for a radial, 10 km length tether demonstrated the possibility of propulsive forces as large as 50 Newtons near the planet. For orbital positions beyond about 2.5 Jovian radii, an EM tether can simultaneously be used for power and increases in the orbital altitude. Although the previous study demonstrated the physical feasibility of EM tether use at Jupiter, it did not address the issues of limited gravity gradient force for tether orientation and the practical use of this technology in an engineered system. This presentation will discuss these issues and current progress in an ongoing science/engineering transitional study.

Gallagher, D. L.; Moore, J.

2000-01-01

353

Longitudinal information and radiation damage in EM calorimetry  

SciTech Connect

The SCC radiation field is higher than that encountered by previous hadron collider detectors. In particular, the electromagnetic (EM) calorimeter compartment sees the highest radiation dose. Since an EM calorimeter also makes the most precise energy measurement, special care must be lavished on this part of a calorimeter. Previous studies have concentrated on Monte Carlo examinations of 2 longitudinal compartments within the EM which can alleviate radiation damage. Recently, it was realized that a ``shower maximum`` detector, such as exists in CDF, also contains information of the conversion point of an electromagnetic shower. As such, it can potentially be used in a fashion analogous to the longitudinal compartments, although it is not designed to be optimized for this role.

Green, D.

1993-02-05

354

Longitudinal information and radiation damage in EM calorimetry  

SciTech Connect

The SCC radiation field is higher than that encountered by previous hadron collider detectors. In particular, the electromagnetic (EM) calorimeter compartment sees the highest radiation dose. Since an EM calorimeter also makes the most precise energy measurement, special care must be lavished on this part of a calorimeter. Previous studies have concentrated on Monte Carlo examinations of 2 longitudinal compartments within the EM which can alleviate radiation damage. Recently, it was realized that a shower maximum'' detector, such as exists in CDF, also contains information of the conversion point of an electromagnetic shower. As such, it can potentially be used in a fashion analogous to the longitudinal compartments, although it is not designed to be optimized for this role.

Green, D.

1993-02-05

355

Quantitation of PET data with the EM reconstruction technique  

SciTech Connect

The expectation maximization (EM) algorithm offers high spatial resolution and excellent noise reduction with low statistics PET data, since it incorporates the Poisson nature of the data. The main difficulties are long computation times, difficulties to find appropriate criteria to terminate the reconstruction and to quantify the resulting image data. In the present work a modified EM algorithm has been implements on a VAX 11/780. Its capability to quantify image data has been tested in phantom studies and in two clinical cases, cerebral blood flow studies and dopamine D2-receptor studies. Data from phantom studies indicate the superiority of images reconstructed with the EM technique compared to images reconstructed with the conventional filtered back-projection (FB) technique in areas with low statistics. At higher statistics the noise characteristics of the two techniques coincide. Clinical data support these findings.

Rosenqvist, G.; Dahlbom, M.; Erikson, L.; Bohm, C.; Blomqvist, G.

1989-02-01

356

EMS Stretcher "Misadventures" in a Large, Urban EMS System: A Descriptive Analysis of Contributing Factors and Resultant Injuries  

PubMed Central

Purpose. There is a paucity of data regarding EMS stretcher-operation-related injuries. This study describes and analyzes characteristics associated with undesirable stretcher operations, with or without resultant injury in a large, urban EMS agency. Methods. In the study agency, all stretcher-related “misadventures” are required to be documented, regardless of whether injury results. All stretcher-related reports between July 1, 2009 and June 30, 2010 were queried in retrospective analysis, avoiding Hawthorne effect in stretcher operations. Results. During the year studied, 129,110 patients were transported. 23 stretcher incidents were reported (0.16 per 1,000 transports). No patient injury occurred. Four EMS providers sustained minor injuries. Among contributing aspects, the most common involved operations surrounding the stretcher-ambulance safety latch, 14/23 (60.9%). From a personnel injury prevention perspective, there exists a significant relationship between combative patients and crew injury related to stretcher operation, Fisher's exact test 0.048. Conclusions. In this large, urban EMS system, the incidence of injury related to stretcher operations in the one-year study period is markedly low, with few personnel injuries and no patient injuries incurred. Safety for EMS personnel and patients could be advanced by educational initiatives that highlight specific events and conditions contributing to stretcher-related adverse events. PMID:22606379

Goodloe, Jeffrey M.; Crowder, Christopher J.; Arthur, Annette O.; Thomas, Stephen H.

2012-01-01

357

Developments in the EM-CCD camera for OGRE  

NASA Astrophysics Data System (ADS)

The Off-plane Grating Rocket Experiment (OGRE) is a sub-orbital rocket payload designed to advance the development of several emerging technologies for use on space missions. The payload consists of a high resolution soft X-ray spectrometer based around an optic made from precision cut and ground, single crystal silicon mirrors, a module of off-plane gratings and a camera array based around Electron Multiplying CCD (EM-CCD) technology. This paper gives an overview of OGRE with emphasis on the detector array; specifically this paper will address the reasons that EM-CCDs are the detector of choice and the advantages and disadvantages that this technology offers.

Tutt, James H.; McEntaffer, Randall L.; DeRoo, Casey; Schultz, Ted; Miles, Drew M.; Zhang, William; Murray, Neil J.; Holland, Andrew D.; Cash, Webster; Rogers, Thomas; O'Dell, Steve; Gaskin, Jessica; Kolodziejczak, Jeff; Evagora, Anthony M.; Holland, Karen; Colebrook, David

2014-07-01

358

Mixture densities, maximum likelihood, and the EM algorithm  

NASA Technical Reports Server (NTRS)

The problem of estimating the parameters which determine a mixture density is reviewed as well as maximum likelihood estimation for it. A particular iterative procedure for numerically approximating maximum likelihood estimates for mixture density problems is considered. This EM algorithm, is a specialization to the mixture density context of a general algorithm of the same name used to approximate maximum likelihood estimates for incomplete data problems. The formulation and theoretical and practical properties of the EM algorithm for mixture densities are discussed focussing in particular on mixtures of densities from exponential families.

Redner, R. A.; Walker, H. F.

1982-01-01

359

Waste fuel, EMS may save plant $1M yearly  

SciTech Connect

A mixture of paper trash and coal ash fueling an Erie, Pa. General Electric plant and a Network 90 microprocessor-based energy-management system (EMS) to optimize boiler efficiency will cost about $3 million and have a three-to-four-year payback. Over half the savings will come from the avoided costs of burning plant-generated trash. The EMS system will monitor fuel requirements in the boiler and compensate for changes in steam demand. It will also monitor plant electrical needs and control the steam diverted for cogeneration. (DCK)

Barber, J.

1982-05-24

360

Airborne EM for geothermal and hydrogeological mapping  

NASA Astrophysics Data System (ADS)

Within the "VIGOR" project, aimed at assessing the geothermal potential of four regions in southern Italy, Airborne EM data have been acquired, modeled and interpreted. The system deployed was SkyTEM, a time-domain helicopter electromagnetic system designed for hydrogeophysical, environmental and mineral investigations. The AEM data provide, after data acquisition, analysis, processing, and modeling, a distribution volume of electrical resistivity, spanning an investigation depth from ground surface of few hundred meters, depending on resistivity condition. Resistivity is an important physical parameter for geothermal investigation, since it proved to be very effective in mapping anomalies due to hydrothermal fluid circulation, which usually has high salt content and produces clayey alteration minerals. Since the project required, among other issues, to define geothermal resources at shallow level, it was decided to perform a test with an airborne electromagnetic geophysical survey, to verify the advantages offered by the system in covering large areas in a short time. The geophysical survey was carried out in Sicily, Italy, in late 2011, over two test sites named "Termini" and "Western Sicily". The two areas were chosen on different basis. "Termini" area is covered by extensive geological surveys, and was going to be investigated also by means of electrical tomography in its northern part. Since geological condition of Sicily, even at shallow depth, is very complex, this area provided a good place for defining the resistivity values of the main geological units outcropping in the region. "Termini" survey has been also an occasion to define relations between resistivity distribution, lithological units and thermal conductivity. The "Western Sicily" area cover the main thermal manifestations of western Sicily, and the research target was to establish whether they are characterized by common hydrogeological or tectonic features that could be mapped by resistivity. SkyTEM data have been acquired in a series of flight lines and were then processed and inverted. In the "Termini" area the flight line spacing had 150 m separation. In the "Western Sicily" area two different line spacing were used: the 1 km spacing was used for the regional mapping, whereas for infill areas, around the main hydrothermal springs, the flight lines had 100 m spacing. The total number of flight line was 4580 km, and the explored surface was in excess of 2000 km2. After acquisition, data were processed to eliminate coupling with infrastructures, and noise. Inversions was then carried out using the quasi 3-D Spatially Constrained Inversion. The obtained resistivity volume has then been the base for a detailed lithological and geothermal interpretation. Lithological and geological maps were used to constrain surface condition and to understand the resistivity ranges of the different lithological units. On the base of resistivity values, lithological units were combined to establish the main litho-resistive units, then modeled at depth, down to achievable investigation depth. This detailed interpretative modeling was also the occasion of recognizing resistivity anomalies within carbonate units, which may possibly represent hydrogeological or hydrothermal bodies. The litho-resitive 3D model is now under investigation to verify how it can represent a viable way to image thermal conductivity variations at depth.

Menghini, A.; Manzella, A.; Viezzoli, A.; Montanari, D.; Maggi, S.

2012-12-01

361

Aquisi??o de Estreptococos Mutans e Desenvolvimento de C?rie Dental em Primog?nitos  

PubMed Central

Objetivo Avaliar o momento de aquisição de estreptococos mutans (EM), desenvolvimento de cárie dental e as variáveis a eles associadas no decorrer de 23 meses, em primogênitos de famílias de baixo nível socioeconômico, desde os sete meses de idade. Método A amostra foi selecionada com base em mães densamente colonizadas por EM, incluindo todos os membros de 14 famílias que conviviam na mesma casa. Foram envolvidos no estudo 14 mães, pais e primogênitos e 8 parentes, na maioria avós. Exames clínicos e radiográficos iniciais determinaram os índices de cárie e condição periodontal dos adultos. Contagens de EM foram feitas em todos os adultos nas duas primeiras visitas. Nas crianças foram avaliados os níveis de EM, o número de dentes e de cáries, em quatro visitas. Resultados A prevalência de EM nos adultos foi alta, estando ausente em apenas um dos pais. EM foram detectados em 1, 2, 3 e 10 crianças, respectivamente nas visitas #1, 2, 3 e 4. A cárie dental foi detectada em apenas três crianças na última visita (aos 30 meses de idade), as quais apresentaram escores de EM significantemente maiores que as crianças sem cárie, na mesma visita. Conclusão Exclusivamente a condição social de baixa renda e mães densamente colonizadas por EM não são sinônimo de colonização precoce e alta atividade de cárie em crianças cuidadas em casa. O desenvolvimento de cárie está significantemente associado a escores elevados de EM nas crianças. PMID:22022218

NOCE, Erica; RUBIRA, Cassia Maria Fischer; da Silva ROSA, Odila Pereira; da SILVA, Salete Moura Bonifacio; BRETZ, Walter Antonio

2011-01-01

362

UNIVERSIDADE DE BRASLIA PROGRAMA DE PS-GRADUAO EM DESENVOLVIMENTO SUSTENTVEL  

E-print Network

de livro com ISBN ou paper em periódico Qualis B2 ou inferior, 15 pontos por livro ou paper em (Máximo 100 pontos) 100 (*) 7 pontos por capítulo de livro com ISBN ou paper em periódico Qualis B2 ou inferior, 15 pontos por livro ou paper em periódico Qualis B1 ou superior. (**) 2,5 por ano/projeto (***) 2

Maier, Rudolf Richard

363

Odontologia do trabalho: Implantação da Odontologia do trabalho: Implantação da Odontologia do trabalho: Implantação da Odontologia do trabalho: Implantação da Odontologia do trabalho: Implantação da atenção em saúde bucal do trabalhador atenção em saúde bucal do trabalhador atenção em saúde bucal do trabalhador atenção em saúde bucal do trabalhador atenção em saúde bucal do trabalhador Occupational odontology: Implantation of attendance in oral health of employees  

Microsoft Academic Search

Key-words Vários fatores interagem determinando o nível de saúde de uma população, entre eles, a relação entre o grau de desenvolvimento do país e as condições de trabalho de seu povo. O presente trabalho tem por objetivo efetuar uma análise dos tópicos de maior pertinência no que concerne a implantação de programas de atenção odontológica voltados aos trabalhadores. Com base

Eduardo Pizzatto; Cléa Adas Saliba Garbin

364

Susceptibility of spotted halibut Verasper variegatus (Pleuronectidae) to infection by the monogenean Neobenedenia girellae (Capsalidae) and oral therapy trials using praziquantel  

Microsoft Academic Search

This study investigated the susceptibility of spotted halibut Verasper variegatus (Pleuronectidae) to infection by the capsalid monogenean Neobenedenia girellae and sought an effective treatment method against this monogenean species in advance of its culture to enable a stable production of V. variegatus by farming. Our results showed that V. variegatus is susceptible to N. girellae. In oral therapy trials, the

Noritaka Hirazawa; Toru Mitsuboshi; Tatsuyoshi Hirata; Kunio Shirasu

2004-01-01

365

Effect of praziquantel treatment of Schistosoma mansoni during pregnancy on immune responses to schistosome antigens among the offspring: results of a randomised, placebo-controlled trial.  

E-print Network

://www.controlled-trials.com/ISRCTN32849447/elliott), offspring of women with Schistosoma mansoni were examined for cytokine and antibody responses to schistosome worm (SWA) and egg (SEA) antigen, in cord blood and at age one year. Relationships to maternal responses and pre...

Tweyongyere, Robert; Mawa, Patrice A; Kihembo, Macklyn; Jones, Frances M; Webb, Emily L; Cose, Stephen; Dunne, David W; Vennervald, Birgitte J; Elliott, Alison M

2011-09-02

366

Effect of artemether administered alone or in combination with praziquantel to mice infected with Plasmodium berghei or Schistosoma mansoni or both  

Microsoft Academic Search

The artemisinins have become key drugs for the treatment and control of malaria, particularly within artemisinin-based combination therapies. Since the artemisinins also exhibit antischistosomal properties, their use in areas where malaria and schistosomiasis are co-endemic may have an effect on both diseases and co-infection might alter drug efficacy. We assessed the antimalarial and antischistosomal efficacies of artemether in mice infected

Xiao Shu-Hua; Jürg Utzinger; Jacques Chollet; Marcel Tanner

2006-01-01

367

Mutagenic effectiveness and efficiency of EMS, DES and gamma-rays in rice  

Microsoft Academic Search

Data on chlorophyll mutation frequency after treatment with EMS, DES and gamma-rays and sequential administration of gamma-rays and the two alkylating agents in three varieties of rice have been used to work out quantitatively the effectiveness and efficiency of each mutagen and combination treatment. For effectiveness, the order is EMS > DES and for efficiency it is EMS > DES

M. L. H. Kaul; A. K. Bhan

1977-01-01

368

Convergence results for the EM approach to mixtures of experts architectures  

Microsoft Academic Search

The Expectation-Maximization (EM) algorithm is an iterative approach to maximum likelihood parameter estimation. Jordan and Jacobs recently proposed an EM algorithm for the mixture of experts architecture of Jacobs, Jordan, Nowlan and Hinton (1991) and the hierarchical mixture of experts architecture of Jordan and Jacobs (1992). They showed empirically that the EM algorithm for these architectures yields significantly faster convergence

Michael I. Jordan; Lei Xu

1995-01-01

369

Quasi-Monte Carlo Sampling to improve the Efficiency of Monte Carlo EM  

E-print Network

Quasi-Monte Carlo Sampling to improve the Efficiency of Monte Carlo EM Wolfgang Jank Department@rhsmith.umd.edu November 17, 2003 Abstract In this paper we investigate an efficient implementation of the Monte Carlo EM al- gorithm based on Quasi-Monte Carlo sampling. The Monte Carlo EM algorithm is a stochastic version

Jank, Wolfgang

370

Hierarchical mixtures of experts and the EM algorithm  

Microsoft Academic Search

We present a tree-structured architecture for supervised learning. The statistical model underlying the architecture is a hierarchical mixture model in which both the mixture coefficients and the mixture components are generalized linear models (GLIMs). Learning is treated as a maximum likelihood problem; in particular, we present an expectation-maximization (EM) algorithm for adjusting the parameters of the architecture. We also develop

Michael I. Jordan; Robert A. Jacobs

1993-01-01

371

Hierarchical Mixtures of Experts and the EM Algorithm  

Microsoft Academic Search

We present a tree-structured architecture for supervised learning. The statistical model underlying the architecture is a hierarchical mixture model in which both the mixture coefficients and the mixture components are generalized linear models (GLIM's). Learning is treated as a maximum likelihood problem; in particular, we present an Expectation-Maximization (EM) algorithm for adjusting the parameters of the architecture. We also develop

Michael I. Jordan; Robert A. Jacobs

1994-01-01

372

An EM algorithm for a semiparametric mixture model  

E-print Network

An EM algorithm for a semiparametric mixture model Laurent Bordes1 Didier Chauveau2 Pierre Marne-la-Vall´ee & CNRS January 2006 Abstract. Recently several authors considered finite mixture models not obvious, and when it occurs, inference methods are rather specific to the mixture model under

Vandekerkhove, Pierre

373

Symmetry-restrained flexible fitting for symmetric EM maps  

PubMed Central

Summary Many large biological macromolecules have inherent structural symmetry, being composed of a few distinct subunits, repeated in a symmetric array. These complexes are often not amenable to traditional high-resolution structural determination methods, but can be imaged in functionally relevant states using cryo-electron microscopy (cryo-EM). A number of methods for fitting atomic-scale structures into cryo-EM maps have been developed, including the molecular dynamics flexible fitting (MDFF) method. However, quality and resolution of the cryo-EM map are the major determinants of a method’s success. In order to incorporate knowledge of structural symmetry into the fitting procedure, we developed the symmetry-restrained MDFF method. The new method adds to the cryo-EM map-derived potential further restraints on the allowed conformations of a complex during fitting, thereby improving the quality of the resultant structure. The benefit of using symmetry-based restraints during fitting, particularly for medium to low-resolution data, is demonstrated for three different systems. PMID:21893283

Chan, Kwok-Yan; Gumbart, James; McGreevy, Ryan; Watermeyer, Jean M.; Sewell, B. Trevor; Schulten, Klaus

2011-01-01

374

Fault Tolerant Control for EMS systems with sensor failure  

Microsoft Academic Search

The paper presents a method to recover the performance of an EMS (Electromagnetic suspension) under faulty air gap measurement. The controller is a combination of classical control loops, a Kalman estimator and analytical redundancy (for the air gap signal). In case of a faulty air gap sensor the air gap signal is recovered using the Kalman filter and analytical redundancy.

Konstantinos Michail; Argyrios Zolotas; Roger Goodall; John Pearson

2009-01-01

375

O ser em metamorfose Jornal Circulao n. 55  

E-print Network

assédio moral quando, em 1912, Kafka escreveu o livro, mas a história serve bem como metáfora para os Samsa, no livro, não desperta de novo humano e morre sozinho, reduzido à condição de inseto, porque não

Floeter, Sergio Ricardo

376

Iterative EM Design of an MRI Magnet Using HTS Materials  

Microsoft Academic Search

Conventional superconducting MRI magnet electromagnetic (EM) design involves the critical parameters of the magnet field and dimensional requirements, plus the low temperature superconductor (LTS) wire properties. When using HTS material for an MRI magnet, in addition to the conventional characteristics of a superconductor, the wire and the joint resistance need also to be considered. This is mainly due to the

Minfeng Xu; Michele Ogle; Xianrui Huang; Kathleen Amm; Evangelos T. Laskaris

2007-01-01

377

Cost-Effectiveness Analysis of Helicopter EMS for Trauma Patients  

Microsoft Academic Search

Study objective: To evaluate the cost-effectiveness of helicopter EMS for trauma patients. Methods: We applied a cost-effectiveness analysis from the service provider's perspective to cost and effectiveness estimates. The cost estimates comprise direct operating costs and additional survivors' hospital costs. The effectiveness estimates were calculated with the TRISS methodology from literature sources and data from a cohort of patients transported

Peter A Gearhart; Richard Wuerz; A. Russell Localio

1997-01-01

378

ISO 14001 EMS standard registration decisions among Canadian organizations  

Microsoft Academic Search

This study characterized the costs and benefits associated with adopting ISO 14001 environmental management system (EMS) standard, based on a survey of ISO 14001-registered organizations in Canada. Decision makers are contemplating whether it is necessary to register to one or more of the ISO and other international standards and, if so, which ones. Furthermore, an organization that has registered separate

Emmanuel K. Yiridoe; J. Stephen Clark; Geb E. Marett; Robert Gordon; Peter Duinker

2003-01-01

379

NUMBER: EM 1.00 (NEW) SECTION: Emergency Management  

E-print Network

NUMBER: EM 1.00 (NEW) SECTION: Emergency Management SUBJECT: Emergency Notification System Policy: Michael Amiridis Issued by: Emergency Management I. Policy Per the Higher Education Opportunity Act the Carolina Alert system. a. Emergency Management Coordinator, University of South Carolina Division of Law

Almor, Amit

380

Leica EM AFS2 Automatic Freeze Substitution System  

E-print Network

" excludes humidity and oxygen · Fast UV polymerization with LED UV lamp Flexibility · Any choice is polymerized under UV light in the EM AFS2 and can be cut and immuno labelled. LED UV lamp FS chamber with new. An integrated LED UV lamp allows immediate polymerization of the samples. Automatic process · One step

Chapman, Michael S.

381

EM Structure-Based Accelerators Working Group Summary  

Microsoft Academic Search

This Working Group (WG) focused on EM Structure-Based Accelerators, which covers a broad area of mechanisms and experiments. Topics covered included dielectric wakefield accelerators (DWA), photonic bandgap accelerators (PBGA), inverse free electron lasers (IFEL), vacuum laser accelerators (VLA), other novel schemes, and supporting analysis and modeling. In addition, this WG was tasked at the Workshop with developing conceptual (strawman) designs

W. D. Kimura; S. M. Lidia

2004-01-01

382

University of Northern British Columbia Posting #12-079EM  

E-print Network

duties, the Residence and Student Life Manager is responsible for the effective management of ResidenceUniversity of Northern British Columbia Posting #12-079EM Residence & Student Life Manager (Regular to a sustainable future. UNBC's main campus is located in Prince George, a city of nearly 80,000 people near

Northern British Columbia, University of

383

The EM Algorithm February 2/4, 2004  

E-print Network

(energy) and the second term, which does not depend on , is the entropy. · Thus, in the M-step, maximizing optimization easier. Expectation-Maximization (EM) Algorithm · Iterative algorithm with two linked steps: E of a marginal probability: (; x) = log p(x|) = log z p(x, z|) which is the incomplete log likelihood. #12

Roweis, Sam

384

Accurate EM-TV algorithm in PET with low SNR  

Microsoft Academic Search

PET measurements of tracers with a lower dose rate or short radioactive half life suffer from extremely low SNRs. In these cases standard reconstruction methods (OSEM, EM, filtered backprojection) deliver unsatisfactory and noisy results. Here, we propose to introduce nonlinear variational methods into the reconstruction process to make an efficient use of a-priori information and to attain improved imaging results.

Alex Sawatzky; Christoph Brune; Frank Wiibbeling; Thomas Kosters; Klaus Schafers; Martin Burger

2008-01-01

385

ISSN 0103-9741 Monografias em Cincia da Computao  

E-print Network

Carlos José Pereira de Lucena Tácio Mauro Pereira de Campos Mônica Priscila Hernandez Moncada-9741 Editor: Prof. Carlos José Pereira de Lucena Novembro, 2009 Um Agente Especialista em Recomendação de Pereira de Lucena, Tácio Mauro Pereira de Campos, Mônica Priscila Hernandez Moncada bneto

Endler, Markus

386

GEOBULLETIN NOvEmBEr 1sT  

E-print Network

GEOBULLETIN NOvEmBEr 1sT 2013 - 1 - GeoBulletin is distributed weekly, by E-mail. Contributions are requested! If you have a news item, a request, an announcement etc. email it to geodept@geology.wisc.edu or leave it at the office, Room 225 by Noon on Wednesday. WEEKS LECTURE - FALL 2013 Nov. 1 Laura Wallace UT

Carlson, Anders

387

A Science Service Feature 1 WHYTHE"EmHER ?  

E-print Network

A Science Service Feature 1 WHYTHE"EmHER ? Dr. Charles F. Erooks, Secretary, American the plain white f l a g has a dark trh@&aLr f l a g above i t the prophesy is fair and warmer by Science Service Science Service, 1115 Conn. Ave., Washington, D .C . #12;

388

Learning Active Basis Models by EM-Type Algorithms  

E-print Network

Learning Active Basis Models by EM-Type Algorithms Zhangzhang Si1, Haifeng Gong1,2, Song-Chun Zhu1 scheme for learning image templates of object categories where the learning is not fully supervised. We and orientations to account for the deformations of object shapes. The model can be easily learned when the objects

Wu, Ying Nian

389

"Cada ser, em si, carrega o dom de ser capaz de ser feliz" : um estudo de caso baseado em Alfred Adler, Lev Vigotski e González Rey.  

E-print Network

??Dissertação (mestrado)—Universidade de Brasília, Faculdade de Educação, 2011. As crianças que apresentam qualquer marca em seu desenvolvimento, seja um defeito físico, ausência sensorial ou, até… (more)

Batista, Anelice da Silva

2011-01-01

390

Composting of rice straw with effective microorganisms (EM) and its influence on compost quality  

PubMed Central

This study aims to assess the effect of EM application on the composting process of rice straw with goat manure and green waste and to evaluate the quality of both compost treatments. There are two treatment piles in this study, in which one pile was applied with EM and another pile without EM. Each treatment was replicated three times with 90 days of composting duration. The parameters for the temperature, pH, TOC and C/N ratio, show that decomposition of organic matter occurs during the 90-day period. The t-test conducted shows that there is a significant difference between compost with EM and compost without EM. The application of EM in compost increases the macro and micronutrient content. The following parameters support this conclusion: compost applied with EM has more N, P and K content (P?EM. Although the Fe in compost with EM is much higher (P?EM, for Zn and Cu, there is no significant difference between treatments. This study suggests that the application of EM is suitable to increase the mineralization in the composting process. The final resultant compost indicated that it was in the range of the matured level and can be used without any restriction. PMID:23390930

2013-01-01

391

Externally triggered renewed bubble nucleation in basaltic magma: The 12 October 2008 eruption at Halema‘uma‘u Overlook vent, K?lauea, Hawai‘i, USA  

NASA Astrophysics Data System (ADS)

From October 2008 until present, dozens of small impulsive explosive eruptions occurred from the Overlook vent on the southeast side of Halema`uma`u Crater, at K?lauea volcano, USA. These eruptions were triggered by rockfalls from the walls of the volcanic vent and conduit onto the top of the lava column. Here we use microtextural observations and data from clasts erupted during the well-characterized 12 October 2008 explosive eruption at Halema`uma`u to extend existing models of eruption triggering. We present a potential mechanism for this eruption by combining microtextural observations with existing geophysical and visual data sets. We measure the size and number density of bubbles preserved in juvenile ejecta using 2D images and X-ray microtomography. Our data suggest that accumulations of large bubbles with diameters of >50?m to at least millimeters existed at shallow levels within the conduit prior to the 12 October 2008 explosion. Furthermore, a high number density of small bubbles <50 ?m is measured in the clasts, implying very rapid nucleation of bubbles. Visual observations, combined with preexisting geophysical data, suggest that the impact of rockfalls onto the magma free surface induces pressure changes over short timescales that (1) nucleated new additional bubbles in the shallow conduit leading to high number densities of small bubbles and (2) expanded the preexisting bubbles driving upward acceleration. The trigger of eruption and bubble nucleation is thus external to the degassing system.

Carey, Rebecca J.; Manga, Michael; Degruyter, Wim; Swanson, Donald; Houghton, Bruce; Orr, Tim; Patrick, Matthew

2012-11-01

392

Superconducting Electromagnetic Suspension (EMS) system for Grumman Maglev concept  

NASA Technical Reports Server (NTRS)

The Grumman developed Electromagnetic Suspension (EMS) Maglev system has the following key characteristics: a large operating airgap--40 mm; levitation at all speeds; both high speed and low speed applications; no deleterious effects on SC coils at low vehicle speeds; low magnetic field at the SC coil--less than 0.35 T; no need to use non-magnetic/non-metallic rebar in the guideway structure; low magnetic field in passenger cabin--approximately 1 G; low forces on the SC coil; employs state-of-the-art NbTi wire; no need for an active magnet quench protection system; and lower weight than a magnet system with copper coils. The EMS Maglev described in this paper does not require development of any new technologies. The system could be built with the existing SC magnet technology.

Kalsi, Swarn S.

1994-01-01

393

Environmental Restoration and Waste Management (EM) program: An introduction  

SciTech Connect

This booklet introduces the reader to the mission and functions of a major new unit within the US Department of Energy (DOE): the Office of Environmental Restoration and Waste Management (EM). The Secretary of Energy established EM in November 1989, implementing a central purpose of DOE's first annual Environmental Restoration and Waste Management Five-Year Plan, which had appeared three months earlier. The contents of this booklet, and their arrangement, reflect the annual update of the Five-Year Plan. The Five-Year Plan supports DOE's strategy for meeting its 30-year compliance and cleanup goal. This strategy involves: focusing DOE's activities on eliminating or reducing known or recognized potential risks to worker and public health and the environment, containing or isolating, removing, or detoxifying onsite and offsite contamination, and developing technology to achieve DOE's environmental goals.

Not Available

1990-12-01

394

ISSN 0103-9741 Monografias em Cincia da Computao  

E-print Network

PUC ISSN 0103-9741 Monografias em Ciência da Computação n° 05/06 IPTV Conceitos, Padrões e Soluções Computação, No. 05/06 ISSN: 0103-9741 Editor: Prof. Carlos José Pereira de Lucena Fevereiro, 2006 IPTV ) ! %& % * & + %& %& 1 >1 , 2 Soluções e provedores de serviço de IPTV 2.1 Soluções : %) % %) % 6

Endler, Markus

395

Da universidade para o mercado de trabalho em onze pases  

E-print Network

Universia está a ser lançado em várias instituições de ensino superior portuguesas. Rede ibero-americana regista por mês 195 mil ofertas ANA BELA FERREIRA Desde quinta-feira que os 23 mil alunos da Universidade a pró-rei- tora, Ana Nunes de Almeida. Ao aderir a esta plataforma, que con- centra não só ofertas

Instituto de Sistemas e Robotica

396

Override problems lead chain to EMS with remote monitor  

SciTech Connect

When R.B. Furniture Co. employees began overriding the Trimax energy management system (EMS) in the company's 61 showrooms, the company shifted to En-Log units for the remaining stores despite the 9- to 22-month payback of the Trimax systems. Remote communications allow monitoring of the En-Log systems and prevent overrides. The case history compares specifications and costs for the two systems. (DCK)

Galvin, C.

1983-09-26

397

EMS users find solutions to voltage-surge problems  

SciTech Connect

The microchips in energy-management systems (EMS) are especially vulnerable to damage due to voltage surges, but the addition of surge suppressors to cut off the peak of spikes at a certain level or the use of fiber-optic cable that transmits light signals instead of electricity can overcome the problem. Users are often unaware that lightning, utility-grid switching, or the shutting down of large equipment can cause surges that garble computer information. (DCK)

Galvin, C.

1983-01-24

398

ISSN 0103-9741 Monografias em Cincia da Computao  

E-print Network

Pereira Sardinha Carlos José Pereira de Lucena Departamento de Informática PONTIFÍCIA UNIVERSIDADE;Monografias em Ciência da Computação, No. 32/05 ISSN: 0103-9741 Editor: Prof. Carlos José Pereira de Lucena * Carolina Howard Felicíssimo, José Alberto Pereira Rodrigues Sardinha, Carlos José de Pereira de Lucena

Endler, Markus

399

The US DOE-EM International Program - 13004  

SciTech Connect

The U.S. Department of Energy (DOE) Office of Environmental Management (EM) conducts international collaboration activities in support of U.S. policies and objectives regarding the accelerated risk reduction and remediation of environmental legacy of the nations' nuclear weapons program and government sponsored nuclear energy research. The EM International Program supported out of the EM Office of the Associate Principal Deputy Assistant Secretary pursues collaborations with foreign government organizations, educational institutions and private industry to assist in identifying technologies and promote international collaborations that leverage resources and link international experience and expertise. In fiscal year (FY) 2012, the International Program awarded eight international collaborative projects for work scope spanning waste processing, groundwater and soil remediation, deactivation and decommissioning (D and D) and nuclear materials disposition initiatives to seven foreign organizations. Additionally, the International Program's scope and collaboration opportunities were expanded to include technical as well as non-technical areas. This paper will present an overview of the on-going tasks awarded in FY 2012 and an update of upcoming international activities and opportunities for expansion into FY 2013 and beyond. (authors)

Elmetti, Rosa R.; Han, Ana M.; Williams, Alice C. [Department of Energy, Office of Environmental Management, 1000 Independence Ave. SW, Washington, DC 20585 (United States)] [Department of Energy, Office of Environmental Management, 1000 Independence Ave. SW, Washington, DC 20585 (United States)

2013-07-01

400

Hydration-layer models for cryo-EM image simulation  

PubMed Central

To compare cryo-EM images and 3D reconstructions with atomic structures in a quantitative way it is essential to model the electron scattering by solvent (water or ice) that surrounds protein assemblies. The most rigorous method for determing the density of solvating water atoms for this purpose has been to perform molecular-dynamics (MD) simulations of the protein-water system. In this paper we adapt the ideas of bulk-water modeling that are used in the refinement of X-ray crystal structures to the cryo-EM solvent-modeling problem. We present a continuum model for solvent density which matches MD-based results to within sampling errors. However, we also find that the simple binary-mask model of Jiang and Brünger (1994) performs nearly as well as the new model. We conclude that several methods are now available for rapid and accurate modeling of cryo-EM images and maps of solvated proteins. PMID:22609687

Shang, Zhiguo; Sigworth, Fred J.

2013-01-01

401

Improving EM&V for Energy Efficiency Programs (Fact Sheet)  

SciTech Connect

This fact sheet describes the objectives of the U.S. Department of Energy Uniform Methods Project to bring consistency to energy savings calculations in U.S. energy efficiency programs. The U.S. Department of Energy (DOE) is developing a framework and a set of protocols for determining gross energy savings from energy efficiency measures and programs. The protocols represent a refinement of the body of knowledge supporting energy efficiency evaluation, measurement, and verification (EM&V) activities. They have been written by technical experts within the field and reviewed by industry experts. Current EM&V practice allows for multiple methods for calculating energy savings. These methods were developed to meet the needs of energy efficiency program administrators and regulators. Although they served their original objectives well, they have resulted in inconsistent and incomparable savings results - even for identical measures. The goal of the Uniform Methods Project is to strengthen the credibility of energy savings determinations by improving EM&V, increasing the consistency and transparency of how energy savings are determined.

Not Available

2012-07-01

402

Retrospectively exploring the importance of items in the decision to leave the emergency medical services (EMS) profession and their relationships to life satisfaction after leaving EMS and likelihood of returning to EMS.  

PubMed

An exit survey was returned by a sample of 127 respondents in fully compensated positions who left the EMS profession, most within 12 months prior to filling out the exit survey. A very high percentage continued to work after leaving EMS. Respondents were asked to rate the importance of each of 17 items in affecting their decision to leave EMS. A higher than anticipated response to a "not applicable" response choice affected the usability of 8 of these items. Nine of the 17 items had at least 65 useable responses and were used for further analysis. Within these 9, stress/burnout and lack of job challenges had the highest importance in affecting the decision to leave EMS, while desire for better pay and benefits had the lowest importance. Desire for career change was positively related to life satisfaction after leaving EMS and negatively related to likelihood of returning to EMS. Stress/burnout was positively related to life satisfaction after leaving EMS. Study limitations and future research issues are briefly discussed. PMID:21695362

Blau, Gary; Chapman, Susan

2011-01-01

403

Urbanidades de uma universidade pública e inclusiva. A implantação da Escola de Artes, Ciências e Humanidades da USP (Universidade de São Paulo\\/ Brasil) na Zona Leste de São Paulo (região ‘periférica’): lições e aprendizados  

Microsoft Academic Search

A implantação da Escola de Artes, Ciências e Humanidades (EACH), a mais nova unidade da Universidade de São Paulo (USP), na Zona Leste da capital paulista, tem caráter eminentemente urbanizador com marcante influência no entorno físico imediato e no próprio âmbito acadêmico em que se insere. Tal caráter apresenta potencial de se transformar em foco indutor de “urbanidades”, pois, além

Marcos Bernardino de Carvalho; Diamantino Alves Pereira

2010-01-01

404

Inhomogeneous Media 3D EM Modeling with Integral Equation Method  

NASA Astrophysics Data System (ADS)

In general, only the half space of earth is considered in electromagnetic exploration. However, for the long bipole source, because the length is close to the height of ionosphere and also most offsets between source and receivers are equal or larger than the height of ionosphere, the effect of ionosphere on the electromagnetic (EM) field should be considered when observation is carried at a very far (about several thousands kilometers) location away from the source. At this point the problem becomes one which should contain ionosphere, atmosphere and earth that is “earth-ionosphere” case. There are a few of literatures to report the electromagnetic field results which is including ionosphere, atmosphere and earth media at the same time. We firstly calculate the electromagnetic fields with the traditional controlled source (CSEM) configuration using integral equation (IE) method for a three layers earth-ionosphere model. The modeling results agree well with the half space analytical results because the effect of ionosphere for this small scale bipole source can be ignorable. The comparison of small scale three layers earth-ionosphere modeling and half space analytical resolution shows that the IE method can be used to modeling the EM fields for long bipole large offset configuration. In order to discuss EM fields’ characteristics for complicate earth-ionosphere media excited by long bipole source in the far-field and wave-guide zones, we first modeled the decay characters of electromagnetic fields for three layers earth-ionosphere model. Because of the effect of ionosphere, the earth-ionosphere electromagnetic fields’ decay curves with given frequency show that there should be an extra wave guide zone for long bipole artificial source, and there are many different characters between this extra zone and far field zone. They are: 1) the amplitudes of EM fields decay much slower; 2) the polarization patterns change; 3) the positions better to measure Zxy and Zyx change; 4) there exits the polarization ellipse of electric and magnetic fields; 5) the long axis direction of the polarization ellipse in wave guide zone changes comparing to quasi static EM fields. In order to further model the EM fields for complex inhomogeneous media, we conducted the EM fields modeling for Biyang depressed basin of China. The bottom depth of the oil basin is about 8km. We added one ionosphere layer with thickness 100km and resistivity 104 Ohm-m and one atmosphere layer with thickness 100km and resistivity 1014 Ohm-m over the solid earth surface during the forward modeling. For easily to compare with the 2D seismic exploration result, we conducted the apparent resistivity modeling of equatorial array for the same survey line as seismic did for an 50km long bipole source with offset 400km and the same frequencies as that used for above three layers model. The modeling apparent resistivity pseudo-section has clearly shown the oil basin geology structure.

di, Q.; Wang, R.; An, Z.; Fu, C.; Xu, C.

2010-12-01

405

Stability of Terrestrial Planets in the Habitable Zone of Gl 777 A, HD 72659, Gl 614, 47 Uma and HD 4208  

E-print Network

We have undertaken a thorough dynamical investigation of five extrasolar planetary systems using extensive numerical experiments. The systems Gl 777 A, HD 72659, Gl 614, 47 Uma and HD 4208 were examined concerning the question of whether they could host terrestrial like planets in their habitable zones (=HZ). First we investigated the mean motion resonances between fictitious terrestrial planets and the existing gas giants in these five extrasolar systems. Then a fine grid of initial conditions for a potential terrestrial planet within the HZ was chosen for each system, from which the stability of orbits was then assessed by direct integrations over a time interval of 1 million years. The computations were carried out using a Lie-series integration method with an adaptive step size control. This integration method achieves machine precision accuracy in a highly efficient and robust way, requiring no special adjustments when the orbits have large eccentricities. The stability of orbits was examined with a determination of the Renyi entropy, estimated from recurrence plots, and with a more straight forward method based on the maximum eccentricity achieved by the planet over the 1 million year integration. Additionally, the eccentricity is an indication of the habitability of a terrestrial planet in the HZ; any value of e>0.2 produces a significant temperature difference on a planet's surface between apoapse and periapse. The results for possible stable orbits for terrestrial planets in habitable zones for the five systems are summarized as follows: for Gl 777 A nearly the entire HZ is stable, for 47 Uma, HD 72659 and HD 4208 terrestrial planets can survive for a sufficiently long time, while for Gl 614 our results exclude terrestrial planets moving in stable orbits within the HZ.

N. Asghari; C. Broeg; L. Carone; R. Casas-Miranda; J. C. Castro Palacio; I. Csillik; R. Dvorak; F. Freistetter; G. Hadjivantsides; H. Hussmann; A. Khramova; M. Khristoforova; I. Khromova; I. Kitiashivilli; S. Kozlowski; T. Laakso; T. Laczkowski; D. Lytvinenko; O. Miloni; R. Morishima; A. Moro-Martin; V. Paksyutov; A. Pal; V. Patidar; B. Pecnik; O. Peles; J. Pyo; T. Quinn; A. Rodriguez; C. Romano; E. Saikia; J. Stadel; M. Thiel; N. Todorovic; D. Veras; E. Vieira Neto; J. Vilagi; W. von Bloh; R. Zechner; E. Zhuchkova

2004-03-05

406

UNIVERSIDADE DE BRASLIA PROGRAMA DE RESIDNCIA MDICO VETERINRIA EM ANATOMIA PATOLGICA  

E-print Network

1 UNIVERSIDADE DE BRASÍLIA PROGRAMA DE RESID�NCIA M�DICO VETERINÁRIA EM ANATOMIA PATOL�GICA ANATOMIA PATOL�GICA VETERINÁRIA PARA O PRIMEIRO PERÍODO LETIVO DE 2011 1. PRE�MBULO 1.1 O Presidente da Veterinária em Anatomia Patológica Veterinária, em conformidade com as exigências do Regulamento deste

Maier, Rudolf Richard

407

UNIVERSIDADE DE BRASLIA (UnB) PROGRAMA DE PS-GRADUAO EM ECONOMIA  

E-print Network

UNIVERSIDADE DE BRASÍLIA (UnB) PROGRAMA DE P�S-GRADUA��O EM ECONOMIA EDITAL No. 06/2013 SELE��O DE CANDIDATOS �S VAGAS DO PROGRAMA DE P�S-GRADUA��O EM ECONOMIA, PARA O CURSO DE MESTRADO PROFISSIONAL, ÁREA DE CONCENTRA��O EM ECONOMIA DO SETOR P�BLICO, PARA O PRIMEIRO PERÍODO LETIVO DE 2014. 1. PRE�MBULO 1.1 O

Maier, Rudolf Richard

408

EmNets 2006 Life Under your Feet 1 Life Under your Feet  

E-print Network

EmNets 2006 Life Under your Feet 1 Life Under your Feet: A Wireless Soil Ecology Sensor Network R the Beginning... EmNets 2006 Life Under your Feet 2 · The Cast · An ecologist: Katalin Szlavecz · An undergrad Step EmNets 2006 Life Under your Feet 3 · The sensors were thoroughly tested in the lab · 2 out of 6

Amir, Yair

409

UNIVERSIDADE DE BRASLIA PROGRAMA DE PS-GRADUAO EM ENSINO DE CINCIAS  

E-print Network

-80, 2011. Disponível em: http://www.portal.fae.ufmg.br/seer/index.php/ensaio/article/viewFile/309/715 Leia-162, 2000. Disponível em: http://www.portal.fae.ufmg.br/seer/index.php/ensaio/article/viewFile/21/52. 5 diferentes abordagens. Rev. Ensaio, v.13, n.3, p.67-80, 2011. Disponível em: http://www.portal.fae.ufmg.br/seer

Maier, Rudolf Richard

410

0.5setgray00.5setgray1 Determinao de coeficientes em equaes  

E-print Network

de Imagens em Medicina Nuclear · SPECT ­ Single Photon Emission Tomography, ­ p. 13/7 #12;Técnicas para Geração de Imagens em Medicina Nuclear · SPECT ­ Single Photon Emission Tomography, · PET ­ Positron Emission Tomograpy; ­ p. 13/7 #12;Técnicas para Geração de Imagens em Medicina Nuclear · SPECT

Cipolatti, Rolci

411

EMS-CO2 Welding: A New Approach to Improve Droplet Transfer Characteristics and Welding Formation  

Microsoft Academic Search

In this article, to improve the stability of droplet transfer and reduce the spatter of pure carbon dioxide gas shield welding (CO2 welding), we propose a new welding method called EMS-CO2 welding by applying an additional longitudinal electromagnetic field to a CO2 welding process (abbr. EMS-CO2 welding). The characteristics of droplet transfer, welding formation and microstructure between EMS-CO2 welding and

Jian Luo; Qian Luo; Xiangjie Wang; Xiaochuan Wang

2010-01-01

412

ADMINISTRATION AND COLLEGE MASTERS 343342 ADMINISTRATION Emergency Medical Service (EMS) .................................................... Bill Taylor  

E-print Network

ADMINISTRATION AND COLLEGE MASTERS 343342 ADMINISTRATION Emergency Medical Service (EMS .................................................. Adria Baker Intramural Sports. Lieberman Media Relations and Information ................................................ Margot Dimond

Richards-Kortum, Rebecca

413

Melasma extra-facial : avaliação clínica, histopatológica e imuno-histoquímica em estudo caso-controle.  

E-print Network

??Fundamentos: O melasma extra-facial é dermatose freqüente na prática clínica dermatológica. Apresenta características especiais em relação tanto aos aspectos clínicos como aos prováveis fatores etiopatogênicos.… (more)

Clarice Gabardo Ritter

2011-01-01

414

Administração peridural de morfina ou tramadol em cães: efeito analgésico e cardiorespiratório.  

E-print Network

??Objetivou-se com este estudo duplo cego avaliar o efeito analgésico e cardiorrespiratório da morfina ou tramadol quando utilizados via peridural, em cadelas submetidas à ovariossalpingohisterectomia… (more)

Celso Sawaya Neves

2009-01-01

415

General 4-week toxicity study with EMS in the rat.  

PubMed

In this subacute toxicity study, ethyl methanesulfonate (EMS) was administered daily by oral gavage to SPF-bred Wistar rats of both sexes at dose levels of 20, 60 and 180/120 mg/kg body weight (bw)/day for a period of 28 days (for 19 days in the high-dose group). A control group was treated similarly with the vehicle, bidistilled water, only. The groups comprised 10 animals per sex, which were sacrificed after 28 days, respectively 19 days in the high-dose group, of treatment. Additional five rats per sex and group were treated accordingly and then allowed a 14 days treatment-free recovery period. Additional six rats per sex and group (three rats per sex in the control group) were treated accordingly and used for hemoglobin adduct analysis after EMS exposure. All animals survived until their scheduled necropsy. Treatment with EMS had a direct dose-dependent effect on food consumption and consequently on body weight at doses > or =20mg/kgbw/day in male rats and at > or =60 mg/kgbw/day in females rats. Hence, treatment with the high dose of 180 mg/kgbw/day had to be interrupted for 9 days after which, the animals were re-dosed at 120 mg/kgbw/day. This dose was also poorly tolerated over the remaining two treatment weeks causing again a marked reduction in food consumption and body weight. A dose of 60 mg/kgbw/day was moderately tolerated over 4 weeks treatment with mean daily food consumption and body weight distinctly lower than in controls. Primary targets of systemic toxicity were the hematopoietic system, thymolymphatic system and sexual organs. Characteristic changes in hematology parameters were decreased red blood cell counts, hematocrit, and hemoglobin concentration. White blood cell counts were also decreased due to reduced lymphocyte and granulocyte populations of each fraction. The corresponding histopathology findings were fatty atrophy of bone marrow and minimal hypocellularity of the white pulp of the spleen. Similarly, treatment with EMS caused an involution of the thymolymphatic system characterized by decreased organ weight of thymus, lymph nodes, and spleen microscopically associated with atrophy of the thymus and hypocellularity of Peyer's patches, lymph nodes and the white pulp of the spleen. The effects on sexual organs included lower organ weight/reduced size for testes, epididymides, seminal vesicles, prostate, and uterus. Tubular atrophy, single cell necrosis of the germ cells and in epididymides reduced spermatozoa were recorded microscopically. The described findings occurred at doses of 60 and 180/120 mg/kgbw/day and were dose-dependent with regard to incidence and severity. Other target organs were the pancreas (acinar cell vacuolation), thyroid gland (follicular cell hypertrophy), and salivary gland (secretory depletion of convoluted ducts). The systemic exposure to EMS was monitored by hemoglobin ethylvaline adduct measurement. The concentration of hemoglobin ethylvaline adducts was linear with the dose and accumulated 11-26-fold over the treatment period. In summary, decreases in food consumption and body weight were the dose-limiting effects of treatment with EMS. Organ toxicity was characterized by depression of cell proliferation (hematopoiesis and spermatogenesis) and changes suggestive of reduced metabolism and/or physiological imbalances (e.g. thymolymphatic system and thyroid gland) without signs of inflammatory or necrotic lesions. For some findings, especially the effects on the thymolymphatic system and sexual organs, it cannot be excluded that starvation-like condition contributed to the occurrence of such changes. The low dose of 20 mg/kgbw/day was basically free of adverse effects despite of a clear evidence for hemoglobin adducts. PMID:19442710

Pfister, Thomas; Eichinger-Chapelon, Anne

2009-11-12

416

Epidemiology of major incidents: an EMS study from Pakistan  

PubMed Central

Background A major incident is defined as an event that owing to the number of casualties has the potential to overwhelm the available resources. This paper attempts to describe the incidence and epidemiology of major incidents dealt with by a government-run emergency medical service (EMS) in the Punjab province of Pakistan, a developing country in South Asia. A major incident in this EMS is defined as any incident that produces three or more patients, or any incident in which extraordinary resources are needed. Methods All the calls received by an EMS Rescue 1122 were studied over a 6-month period. Calls that were defined as major incidents were identified, and further details were sought from the districts regarding these incidents. Questions specifically asked were the type of incident, time of the incident, response time for the incident, the resources needed, and the number of dead and injured casualties. Retrospective data were collected from the submitted written reports. Results Road traffic crashes (RTCs) emerged as the leading cause of a major incident in the province of Punjab and also led to the greatest number of casualties, followed by fire incidents. The total number of casualties was 3,380, out of which 73.7% were RTC victims. There was a high rate of death on the scene (10.4%). Certain other causes of major incidents also emerged, including violence, gas explosions and drowning. Conclusion Road traffic crashes are the most common cause of a major incident in developing countries such as Pakistan. Injury prevention initiatives need to focus on RTCs. PMID:21798011

2011-01-01

417

Transmission characteristics of EM wave in a finite thickness plasma  

NASA Astrophysics Data System (ADS)

One of the key factors for solving the problems of re-entry communication interruption is electromagnetic (EM) wave transmission characteristics in a plasma. Theoretical and experimental studies were carried out on specific transmission characteristics for different plasma sheath characteristic under thin sheath condition in re-entry state. The paper presents systematic studies on the variations of wave attenuation characteristics versus plasma sheath thickness L, collision frequency ?, electron density n e and wave working frequency f in a ? 800mm high temperature shock tube. In experiments, L is set to 4 cm and 38 cm. ? is 2 GHz and 15 GHz. n e is from 1×1010 cm-3 to 1×1013 cm-3, and f is set to 2, 5, 10, 14.6 GHz, respectively. Meanwhile, Wentzel-Kramers-Brillouin (WKB) and finite-difference time-domain (FDTD) methods are adopted to carry out theoretical simulation for comparison with experimental results. It is found that when L is much larger than EM wavelength ? (thick sheath) and ? is large, the theoretical result is in good agreement with experimental one, when sheath thickness L is much larger than ?, while ? is relatively small, two theoretical results are obviously different from the experimental ones. It means that the existing theoretical model can not fully describe the contribution of ?. Furthermore, when L and ? are of the same order of magnitude (thin sheath), the experimental result is much smaller than the theoretical values, which indicates that the current model can not properly describe the thin sheath effect on EM attenuation characteristics.

Zhu, Nai-Yi; Huang, Li-Shun; Wu, Bin; Yu, Xi-Long; Wu, Run-Hui; Meng, Gang; Ren, Ai-Min; Hu, Xin-Tian

2013-04-01

418

SEI: Junior E&M I Course Materials - Electrodynamics  

NSDL National Science Digital Library

This is a collection of resources for teaching electrodynamics. Included are homework questions, concept tests, student tutorials, and information about common student difficulties in the topic and ways to address these difficulties. This material was developed as part of a education research-based course transformation for junior level E&M. All of the resources developed for this course are available, sorted by individual topic and type, at http://www.compadre.org/psrc/items/Relations.cfm?ID=7891. Because this topic is not typically taught in depth in the courses used in developing these course materials, these materials are less complete than the other sections.

Pollock, Steven J.; Chasteen, Stephanie V.

2010-09-24

419

A compulsator driven rapid-fire EM-gun  

SciTech Connect

A compulsator-driven railgun is an attractive alternative to the homopolar generator-inductor-switch configuration, especially for repetitive duty. A conceptual design of a rapid-fire EM-gun system is presented. The generator is sized to accelerate a 0.08-kg projectile to 2 to 3 km/s at a 60 pulse-per-second repetition rate. Initial design parameters are discussed, and example current and velocity waveforms are given. The generator is discharged at the proper phase angle to provide a current zero just as the projectile exits the muzzle of the railgun.

Pratap, S.B.; Bird, W.L.

1984-03-01

420

SEI: Junior E&M I Course Materials - Math Fundamentals  

NSDL National Science Digital Library

This is a collection of resources for teaching mathematical fundamentals of electro- and magnetostatics constructed over the course of four semesters of a transformed junior-level Electricity and Magnetism course. Included are homework questions, concept tests, and information about common student difficulties in the topic and ways to address these difficulties. This material was developed as part of a education research-based course transformation for junior level E&M. All of the resources developed for this course are available, sorted by individual topic and type, at http://www.compadre.org/psrc/items/Relations.cfm?ID=7891.

Pollock, Steven J.; Chasteen, Stephanie V.

2010-06-29

421

Hospital picks EMS from 3 guaranteed savings bids  

SciTech Connect

A Wheeling, WV medical center stipulated $54,000 guaranteed annual savings from all bidders when it selected an MCC Powers System 600 energy management system (EMS) from among several bidders. A DOE grant will reduce the payback period to one year. A staff energy audit was the basis for the guaranteed savings figure. Programming ease and the ability to display building systems were positive features of the System 600 besides the low bid, but visits to other facilities using the system were a major factor in the decision. (DCK)

Galvin, C.

1983-10-24

422

Aristarchus's <em>On the Sizes and Distances of the Sun and the Moonem>: Greek and Arabic Texts  

NASA Astrophysics Data System (ADS)

In the 1920s, T. L. Heath pointed out that historians of mathematics have "given too little attention to Aristarchus". This is still true today. The Greek text of Aristarchus's On the Sizes and Distances of the Sun and the Moonem> has received little attention; the Arabic editions virtually none. Much of what this text has to tell us about ancient and medieval mathematics and the mathematical sciences has gone unnoticed. It should be taken as an important source for our understanding of the mathematical sciences of the early Hellenistic period.

Berggren, J. L.; Sidoli, N.

2007-05-01

423

Efeitos da suplementação aguda de aspartato de arginina na fadiga muscular em voluntários treinados  

Microsoft Academic Search

RESUMO A atividade física influi em mecanismos específicos responsá- veis pela redução da produção de força e conseqüentemente à fadiga. A preocupação em melhorar o desempenho físico tem sido propostos; observamos que estudos dão atenção para reduzir acú- mulos dos metabólitos que diminuem a fadiga durante o exercício físico intenso, usando aminoácidos conhecidos por induzir mudan- ças metabólicas, entre eles

Ricardo Pombo Sales; Carlos Eduardo César Miné; Andréia Dellú Franco; Érika Lima Rodrigues; Renato de Souza e Silva; José Carlos Cogo; Rodrigo A. B. Lopes-Martins; Rodrigo Lazo Osorio; Wellington Ribeiro

2005-01-01

424

Efeito da vitamina C no ganho de peso e em parâmetros hematológicos de tambaqui  

Microsoft Academic Search

Resumo - O objetivo deste trabalho foi avaliar o efeito da suplementação dietária com ácido L-ascórbico (vitamina C) no ganho de peso e em parâmetros hematológicos de juvenis de tambaqui, Colossoma macropomum. Após dez semanas, em que foram alimentados com dietas contendo 0, 100 e 500 mg de ácido L-ascórbico por kg de ração, os peixes foram capturados e imediatamente

Edsandra Campos Chagas; Adalberto Luís Val

2003-01-01

425

Method for evaluating compatibility of commercial electromagnetic (EM) microsensor tracking systems with surgical and imaging tables  

NASA Astrophysics Data System (ADS)

Electromagnetic (EM) tracking systems have been successfully used for Surgical Navigation in ENT, cranial, and spine applications for several years. Catheter sized micro EM sensors have also been used in tightly controlled cardiac mapping and pulmonary applications. EM systems have the benefit over optical navigation systems of not requiring a line-of-sight between devices. Ferrous metals or conductive materials that are transient within the EM working volume may impact tracking performance. Effective methods for detecting and reporting EM field distortions are generally well known. Distortion compensation can be achieved for objects that have a static spatial relationship to a tracking sensor. New commercially available micro EM tracking systems offer opportunities for expanded image-guided navigation procedures. It is important to know and understand how well these systems perform with different surgical tables and ancillary equipment. By their design and intended use, micro EM sensors will be located at the distal tip of tracked devices and therefore be in closer proximity to the tables. Our goal was to define a simple and portable process that could be used to estimate the EM tracker accuracy, and to vet a large number of popular general surgery and imaging tables that are used in the United States and abroad.

Nafis, Christopher; Jensen, Vern; von Jako, Ron

2008-03-01

426

ISOLAMENTO E IDENTIFICAÇÃO DE BACTÉRIAS CANDIDATAS A PROBIÓTICOS EM CAMARÕES DA ESPÉCIE LITOPENAEUS VANNAMEI  

Microsoft Academic Search

RESUMO O objetivo desse trabalho foi isolar e identificar bactérias candidatas a probióticos do trato intestinal de camarões da espécie Litopenaeus vannamei, em diferentes fases de desenvolvimento. Foram utilizados camarões nas fases de recria e inicial (pós-larva) e de crescimento (juvenil), os quais eram adaptados à água doce da Fazenda BAHIA PESCA, especializada em aqüicultura, localizada no município de Santo

M. M. COSTA

427

NCLEO DE ESTUDOS EM DIREITO CIVIL CONSTITUCIONAL PROJETO DE PESQUISA VIRADA DE COPRNICO  

E-print Network

Jurídicas Contratuais e Responsabilidade Civil; (iv) Relações Jurídicas Familiares e Sucessão; (v) Ensino1 N�CLEO DE ESTUDOS EM DIREITO CIVIL CONSTITUCIONAL PROJETO DE PESQUISA VIRADA DE COP�RNICO ESTUDOS EM DIREITO CIVIL CONSTITUCIONAL ­ PROJETO DE PESQUISA VIRADA DE COP�RNICO, observadas as seguintes

Paraná, Universidade Federal do

428

BSSDATA - um programa otimizado para filtragem de dados em radioastronomia solar  

Microsoft Academic Search

A partir de 1998, entrou em operação regular no INPE, em São José dos Campos, o Brazilian Solar Spectroscope (BSS). O BSS é dedicado às observações de explosões solares decimétricas com alta resolução temporal e espectral, com a principal finalidade de investigar fenômenos associados com a liberação de energia dos \\

A. R. F. Martinon; H. S. Sawant; F. C. R. Fernandes; S. Stephany; A. J. Preto; K. M. Dobrowolski

2003-01-01

429

BWR loss-of-coolant accident analysis capability of the WRAP-EM system  

Microsoft Academic Search

The modular computational system known as the Water Reactor Analysis Package (WRAP) has been extended to provide the computational tools required to perform a complete analysis of LOCAs in BWRs. The new system is known as the WRAP-EM (Evaluation Model) system and will be used by NRC in interpreting and evaluating reactor vendor EM methods and computed results. The system

M. R. Buckner; R. R. Beckmeyer; M. V. Gregory; R. L. Reed; W. G. Winn

1979-01-01

430

Potential cauchy-poisson waves generated by submarine eruptions of kick 'em Jenny volcano  

Microsoft Academic Search

Kick 'em Jenny is the only known currently active submarine volcano in the Lesser Antilles. The volcano has erupted at least 10 times since first being discovered in 1939 and the summit has shoaled from a depth of ~232 m in 1962 to its present-day depth of ~150 m. Kick 'em Jenny is located in a province of explosive volcanism,

M. S. Smith; J. B. Shepherd

1995-01-01

431

Uterus Image Segmentation Using Multi-feature EM Algorithm Based on Gabor Filter  

Microsoft Academic Search

In this work the image is segmented effectively based on texture feature by reducing the noise. For effective image segmentation Expectation-Maximization (EM) algorithm based on Gabor filter is used. The EM algorithm is applied on 2D Ultrasonic image of uterus and tested. The Gabor function has been recognized by its multiresolution properties and the precision of locating the texture features

S. Malarkhodi; R. S. D. W. Banu

2010-01-01

432

On the EM Algorithm and Bootstrap Approach Combination for Improving Satellite Image Fusion  

Microsoft Academic Search

This paper discusses EM algorithm and Bootstrap approach combination applied for the improvement of the satellite image fusion process. This novel satellite image fusion method based on estimation theory EM algorithm and reinforced by Bootstrap approach was successfully implemented and tested. The sensor images are firstly split by a Bayesian segmentation method to determine a joint region map for the

Tijani Delleji; Mourad Zribi; Ahmed Ben

2008-01-01

433

A redução dos níveis de cortisol sanguíneo através da técnica de relaxamento progressivo em nadadores  

Microsoft Academic Search

Reduction of blood cortisol levels through the progres- sive relaxation technique in swimmers Objetivo: Analisar os efeitos da técnica de relaxamento progressivo na redução\\/controle dos níveis de cortisol san- guíneo em nadadores durante determinado período de trei- namentos. Metodologia: Nadadores de ambos os sexos (n = 23) foram divididos em dois grupos: experimental - GE (n = 11), submetido a

Maurício Gattás; Bara Filho; Luiz Carlos Scipião Ribeiro; Renato Miranda; Mônica Tavares Teixeira

2002-01-01

434

Anxiety levels in EMS providers: Effects of violence and shift schedules  

Microsoft Academic Search

We tried to measure anxiety levels in emergency medical service (EMS) providers to determine the effects of (1) having had a violent encounter during a shift and (2) different shift schedules, conducting a prospective observational study over 3 months in an urban EMS system setting. A convenience sample of 23 EMTs and 40 EMT-Ps was observed. Anxiety levels were measured

Elisabeth Fowlie Mock; Keith D Wrenn; Seth W Wright; T. Chadwick Eustis; Corey M Slovis

1999-01-01

435

Prevalência de sobrepeso\\/obesidade em crianças e adolescentes com constipação crônica funcional  

Microsoft Academic Search

RESUmO Objetivo: Avaliar a prevalência do sobrepeso\\/obesidade em um grupo de crianças com constipação crônica funcional. Métodos: Estudo retrospectivo com 257 crianças de dois a 15 anos com constipação crônica funcional diag- nosticada segundo critérios de Roma II, atendidas con- secutivamente em clínica terciária de gastroenterologia pediátrica. Informações demográficas, clínicas, diagnós - ticas e antropométricas foram obtidas de prontuários. O

Francisca Teresa V. Faleiros; Cristiane Camargo Omae; Cristiane Yoshie Nakazawa; Mary de Assis Carvalho; Nilton Carlos Machado

2008-01-01

436

Competência social e empatia: um estudo sobre resiliência com crianças em situação de pobreza  

Microsoft Academic Search

Social competence and empathy: Study about resilience with children in poverty Resumo O objetivo desse estudo foi avaliar a competência social e a empatia em crianças escolares que vivem em situação de po- breza. Participaram da pesquisa 100 crianças, de ambos os sexos, com idades entre seis e nove anos. Os instrumentos utilizados foram o Teste das Histórias Incompletas (THI)

Alessandra Marques Cecconello; Sílvia Helena Koller

2000-01-01

437

2.5D EM modeling in TIV conductive media Torgeir Wiik  

E-print Network

2.5D EM modeling in TIV conductive media Torgeir Wiik , Bjørn Ursin and Ketil Hokstad, Norwegian domain EM model- ing in conductive media, i.e. in media which are assumed invariant in one direction. Further, we consider media which are transversely isotropic in the vertical direction 1 #12;(TIV), thus

Ursin, Bjørn

438

Cryo-EM modeling by the molecular dynamics flexible fitting method  

PubMed Central

The increasing power and popularity of cryo-electron (cryo-EM) microscopy in structural biology brought about the development of so-called hybrid methods, which permit the interpretation of cryo-EM density maps beyond their nominal resolution in terms of atomic models. The Cryo-EM Modeling Challenge 2010 is the first community effort to bring together developers of hybrid methods as well as cryo-EM experimentalists. Participating in the challenge, the molecular dynamics flexible fitting (MDFF) method was applied to a number of cryo-EM density maps. The results are described here with special emphasis on the use of symmetry-based restraints to improve the quality of atomic models derived from density maps of symmetric complexes; on a comparison of the stereochemical quality of atomic models resulting from different hybrid methods; and on application of MDFF to electron crystallography data. PMID:22696404

Chan, Kwok-Yan; Trabuco, Leonardo G.; Schreiner, Eduard; Schulten, Klaus

2012-01-01

439

PERFIL DOS ACIDENTES POR LIQUIDOS AQUECIDOS EM CRIANÇAS ATENDIDAS EM CENTRO DE REFERÊNCIA DE FORTALEZA The Profile of Accidents by Hot Liquids in Children Attended at a Reference Center in Fortaleza  

Microsoft Academic Search

RESUMO As queimaduras são acidentes frequentes e representam a segunda causa de morte na infância. Este trabalho objetivou identificar o perfil dos acidentes em crianças queimadas por líquidos aquecidos. Estudo descritivo, realizado com 62 pais de crianças internadas em um Centro de Tratamento para Queimados, em Fortaleza, Ceará, no período de janeiro a junho de 2002. As variáveis estudadas foram:

Rita Neuma; Dantas Cavalcante; Érika Porto Xavier; Luiza Jane; Eyre de Souza

440

A photometric study of the W UMa-type eclipsing binary system 1SWASP J160156.04 + 202821.6  

NASA Astrophysics Data System (ADS)

B, V, R and I light curves of the eclipsing binary system 1SWASP J160156.04 + 202821.6 (J1601) have been constructed, for the first time, based on the CCD observations obtained using the 1.88 m telescope of Kottamia Astronomical Observatory (KAO), Egypt, during June, 2013. Twenty new times of minima (8 primary and 12 secondary) have been derived from the presented photometry, and a new ephemeris has been determined. The analysis of the corresponding light curves is made using Djuraševi?’s inverse problem method. The light-curve asymmetry is explained using a Roche model with spots on system components. The analysis showed that the system is in an overcontact configuration (fover?13%) with a small temperature difference between the components (?T=Th-Tc?120 K), indicating a good thermal contact. The analysis suggests that J1601 is an A-subtype of W UMa-type eclipsing systems, where the primary component is the hotter and more massive one.

Essam, A.; Djuraševi?, G.; Ahmed, N. M.; Jurkovi?, M.

2014-10-01

441

EMS1 gene expression in primary breast cancer: relationship to cyclin D1 and oestrogen receptor expression and patient survival  

Microsoft Academic Search

The EMS1 and CCND1 genes at chromosome 11q13 are amplified in about 15% of primary breast cancers but appear to confer different phenotypes in ER positive and ER negative tumours. Since there are no published data on EMS1 expression in large series of breast cancers we examined the relationship of EMS1 expression with EMS1 gene copy number and expression of

Rina Hui; Jonathon R Ball; R Douglas Macmillan; Frances S Kenny; Owen WJ Prall; Douglas H Campbell; Ann L Cornish; Richard A McClelland; Roger J Daly; John F Forbes; Roger W Blamey; Elizabeth A Musgrove; John FR Robertson; Robert I Nicholson; Robert L Sutherland

1998-01-01

442

THE WHITE DWARF IN EM CYGNI: BEYOND THE VEIL  

SciTech Connect

We present a spectral analysis of the Far Ultraviolet Spectroscopic Explorer (FUSE) spectra of the eclipsing double-line spectroscopic binary EM Cygni (EM Cyg), a Z Cam DN system. The FUSE spectrum, obtained in quiescence, consists of four individual exposures (orbits): two exposures, at orbital phases {phi} {approx} 0.65 and {phi} {approx} 0.90, have a lower flux; and two exposures, at orbital phases {phi} = 0.15 and 0.45, have a relatively higher flux. The change of flux level as a function of the orbital phase is consistent with the stream material (flowing over and below the disk from the hot spot region to smaller radii) partially masking the white dwarf. We carry out a spectral analysis of the FUSE data, obtained at phase 0.45 (when the flux is maximal), using synthetic spectra generated with the codes TLUSTY and SYNSPEC. Using a single white dwarf spectral component, we obtain a white dwarf temperature of 40, 000 K {+-} 1000 K, rotating at 100 km s{sup -1}. The white dwarf, or conceivably, the material overflowing the disk rim, shows suprasolar abundances of silicon, sulphur, and possibly nitrogen. Using a white dwarf+disk composite model, we obtain that the white dwarf temperature could be even as high as 50,000 K, contributing more than 90% of the FUV flux, and the disk contributing less than 10% must have a mass accretion rate reaching 10{sup -10} M{sub sun} yr{sup -1}. The single white dwarf model fits the absorption lines better than the white dwarf+disk model, but the white dwarf+disk model fits better the continuum in the shorter wavelengths. In both cases, however, we obtain that the white dwarf temperature is much higher than previously estimated. We emphasize the importance of modeling the spectra of EM Cyg around phase {phi} < 0.5, when the white dwarf and disk are facing the observer, and we suggest that the discrepancy between the present analysis and previous spectral analysis might be due to the occulting effect of the stream veiling the white dwarf and disk.

Godon, Patrick; Sion, Edward M. [Department of Astronomy and Astrophysics, Villanova University, Villanova, PA 19085 (United States); Barrett, Paul E. [United States Naval Observatory, Washington, DC 20392 (United States); Linnell, Albert P. [Department of Astronomy, University of Washington, Seattle, WA 98195 (United States)], E-mail: patrick.godon@villanova.edu, E-mail: edward.sion@villanova.edu, E-mail: barrett.paul@usno.navy.mil, E-mail: linnell@astro.washington.edu, E-mail: godon@stsci.edu

2009-07-10

443

A Gentle Tutorial of the EM Algorithm and its Application to Parameter Estimation for Gaussian Mixture and Hidden Markov Models  

Microsoft Academic Search

We describe the maximum-likelihood parameter estimation problem and how the Expectation- Maximization (EM) algorithm can be used for its solution. We first describe the abstract form of the EM algorithm as it is often given in the literature. We then develop the EM pa- rameter estimation procedure for two applications: 1) finding the parameters of a mixture of Gaussian densities,

Jeff A. Bilmes

1997-01-01

444

Efeitos da monensina sobre a fermentação e sensibilidade de bactérias ruminais de bovinos sob dietas ricas em volumoso ou concentrado  

Microsoft Academic Search

RESUMO - Objetivou-se avaliar os efeitos da monensina sobre as mudanças nos padrões de fermentação e resistência à perda do potássio intracelular das bactérias ruminais provenientes de quatro bovinos recebendo dietas ricas em volumoso ou concentrado. As bactérias obtidas por centrifugação diferencial foram resuspensas em um meio pobre em potássio, no qual foi medida a perda do p otássio intracelular,

Rogério de Paula Lana; James B. Russell

2001-01-01

445

Halema'uma'u Vent  

USGS Multimedia Gallery

This photo shows the view with the naked eye during the high lava stand shown in the thermal video from today. When the lava is at a high stand like this, the plume becomes very thin and a rare view of the lava pond is possible. Typically, the fume is too thick to view the lava surface with the nake...

2010-06-18

446

The EM SSAB Annual Work Plan Process: Focusing Board Efforts and Resources - 13667  

SciTech Connect

One of the most daunting tasks for any new member of a local board of the Environmental Management Site Specific Advisory Board (EM SSAB) is to try to understand the scope of the clean-up activities going on at the site. In most cases, there are at least two or three major cleanup activities in progress as well as monitoring of past projects. When planning for future projects is added to the mix, the list of projects can be long. With the clean-up activities involving all major environmental media - air, water, soils, and groundwater, new EM SSAB members can find themselves totally overwhelmed and ineffective. Helping new members get over this initial hurdle is a major objective of EM and all local boards of the EM SSAB. Even as members start to understand the size and scope of the projects at a site, they can still be frustrated at the length of time it takes to see results and get projects completed. Many project and clean-up timelines for most of the sites go beyond 10 years, so it's not unusual for an EM SSAB member to see the completion of only 1 or 2 projects over the course of their 6-year term on the board. This paper explores the annual work planning process of the EM SSAB local boards, one tool that can be used to educate EM SSAB members into seeing the broader picture for the site. EM SSAB local work plans divide the site into projects focused on a specific environmental issue or media such as groundwater and/or waste disposal options. Projects are further broken down into smaller segments by highlighting major milestones. Using these metrics, local boards of the EM SSAB can start to quantify the effectiveness of the project in achieving the ultimate goal of site clean-up. These metrics can also trigger board advice and recommendations for EM. At the beginning of each fiscal year, the EM SSAB work plan provides a road map with quantifiable checkpoints for activities throughout the year. When the work plans are integrated with site-specific, enforceable regulatory milestones, they can provide a comprehensive work plan for not only the board, but also regulators, site contractors, and DOE. Because the work plans are reviewed and approved by DOE, they carry some weight in holding local boards of the EM SSAB accountable. This structure provides the basis for local boards to achieve their primary function, to provide DOE with information, advice, and recommendations concerning issues affecting the EM program at the site. (authors)

Young, Ralph [Paducah Citizens Advisory Board (United States)] [Paducah Citizens Advisory Board (United States)

2013-07-01

447

QCD effective potential with strong U(1)em magnetic fields  

NASA Astrophysics Data System (ADS)

We derive the analytic expression for the one-loop SU(Nc) QCD effective potential including Nf flavor quarks which nonlinearly interact with the chromomagnetic background field and the external U(1)em magnetic field. After the renormalization of couplings and fields, we obtain the correct one-loop ? functions of both QCD and QED, and the resulting effective potential satisfies the renormalization group equation. We investigate the effect of the magnetic field on the QCD vacuum by using the effective potential, in particular for the color SU(3) case with the three flavors (u ,d,s). Our result shows that the chromomagnetic field prefers to be parallel to the external magnetic field. Furthermore, quark loop contributions to the effective potential with the magnetic field enhance gluonic contributions, and then the chromomagnetic condensate increases with an increasing magnetic field. This result supports the recent observed gluonic magnetic catalysis at zero-temperature in lattice QCD.

Ozaki, Sho

2014-03-01

448

EM Properties of Magnetic Minerals at RADAR Frequencies  

NASA Technical Reports Server (NTRS)

Previous missions to Mars have revealed that Mars surface is magnetic at DC frequency. Does this highly magnetic surface layer attenuate RADAR energy as it does in certain locations on Earth? It has been suggested that the active magnetic mineral on Mars is titanomaghemite and/or titanomagnetite. When titanium is incorporated into a maghemite or magnetite crystal, the Curie temperature can be significantly reduced. Mars has a wide range of daily temperature fluctuations (303K - 143K), which could allow for daily passes through the Curie temperature. Hence, the global dust layer on Mars could experience widely varying magnetic properties as a function of temperature, more specifically being ferromagnetic at night and paramagnetic during the day. Measurements of EM properties of magnetic minerals were made versus frequency and temperature (300K- 180K). Magnetic minerals and Martian analog samples were gathered from a number of different locations on Earth.

Stillman, D. E.; Olhoeft, G. R.

2005-01-01

449

EM modeling of RF drive in DTL tank 4  

SciTech Connect

A 3-D MicroWave Studio model for the RF drive in the LANSCE DTL tank 4 has been built. Both eigensolver and time-domain modeling are used to evaluate maximal fields in the drive module and RF coupling. The LANSCE DTL tank 4 has recently been experiencing RF problems, which may or may not be related to its replaced RF coupler. This situation stimulated a request by Dan Rees to provide EM modeling of the RF drive in the DTL tank 4 (T4). Jim O'Hara provided a CAD model that was imported into the CST Microwave Studio (MWS) and after some modifications became a part of a simplified MWS model of the T4 RF drive. This technical note describes the model and presents simulation results.

Kurennoy, Sergey S. [Los Alamos National Laboratory

2012-06-19

450

SEI: Junior E&M I Course Materials - Tutorials  

NSDL National Science Digital Library

This collection of tutorials and tutorial pre-tests was constructed for a transformed junior-level Electricity and Magnetism course. These tutorials are weekly student sessions, modeled after research-validated curricula developed at the University of Washington. Using these materials in study/recitation sections, students work in small groups with the instructor as a learning coach. The materials are designed to target known student difficulties, to elicit and develop conceptual understanding and math/physics connections. They also help faculty listen to student reasoning, get a clearer sense of student ideas, and determine where they are struggling. This material was developed as part of a education research-based course transformation for junior level E&M. All of the resources developed for this course are available, sorted by individual topic and type, at http://www.compadre.org/psrc/items/Relations.cfm?ID=7891.

Pollock, Steven J.; Chasteen, Stephanie V.; Kinney, Edward; Dubson, Michael

2010-06-10

451

SEI: Junior E&M I Course Materials - Homework  

NSDL National Science Digital Library

This homework question collection was constructed over the course of four semesters of a transformed junior-level Electricity and Magnetism course on electro- and magneto-statics. Many questions are related to textbook problems, but with added elements of explanation, sense-making, estimation or approximation, real-world connections, and multiple-representations. Not all these homework questions were used in the course design project. Some problems used include detailed instructor notes, including statistics on student performance on each homework problem assigned. The homework solutions are only available to instructors by writing the authors, Steven.Pollock@colorado.edu This material was developed as part of a education research-based course transformation for junior level E&M. All of the resources developed for this course are available, sorted by individual topic and type, at http://www.compadre.org/psrc/items/Relations.cfm?ID=7891.

Pollock, Steven J.; Chasteen, Stephanie V.

2010-06-10

452

EM Structure-Based Accelerators Working Group Summary  

SciTech Connect

This Working Group (WG) focused on EM Structure-Based Accelerators, which covers a broad area of mechanisms and experiments. Topics covered included dielectric wakefield accelerators (DWA), photonic bandgap accelerators (PBGA), inverse free electron lasers (IFEL), vacuum laser accelerators (VLA), other novel schemes, and supporting analysis and modeling. In addition, this WG was tasked at the Workshop with developing conceptual (strawman) designs for a 1-GeV accelerator system based upon any of the experimentally-proven approaches covered in this WG. Two strawmen designs were developed based upon IFELs and DWAs. The presentations given and strawmen designs indicate great progress has been made in many areas. Proof-of-principle experiments will occur shortly in PBGA and VLA. Other well-proven devices, such as IFELs, are becoming accepted as 'workhorse' providers of microbunches.

Kimura, W.D. [STI Optronics, Inc., 2755 Northup Way, Bellevue, WA 98004 (United States); Lidia, S.M. [Lawrence Berkeley National Laboratory, Berkeley, CA 94720 (United States)

2004-12-07

453

Speech articulator measurements using low power EM-wave sensors  

SciTech Connect

Very low power electromagnetic (EM) wave sensors are being used to measure speech articulator motions as speech is produced. Glottal tissue oscillations, jaw, tongue, soft palate, and other organs have been measured. Previously, microwave imaging (e.g., using radar sensors) appears not to have been considered for such monitoring. Glottal tissue movements detected by radar sensors correlate well with those obtained by established laboratory techniques, and have been used to estimate a voiced excitation function for speech processing applications. The noninvasive access, coupled with the small size, low power, and high resolution of these new sensors, permit promising research and development applications in speech production, communication disorders, speech recognition and related topics. {copyright} {ital 1998 Acoustical Society of America.}

Holzrichter, J.F.; Burnett, G.C.; Ng, L.C. [Lawrence Livermore National Laboratory, P.O. Box 808, Livermore, California 94551 (United States)] [Lawrence Livermore National Laboratory, P.O. Box 808, Livermore, California 94551 (United States); Lea, W.A. [Speech Science Institute, P.O. Box 240428, Apple Valley, Minnesota 55124 (United States)] [Speech Science Institute, P.O. Box 240428, Apple Valley, Minnesota 55124 (United States)

1998-01-01

454

Integrated EM & Thermal Simulations with Upgraded VORPAL Software  

SciTech Connect

Nuclear physics accelerators are powered by microwaves which must travel in waveguides between room-temperature sources and the cryogenic accelerator structures. The ohmic heat load from the microwaves is affected by the temperature-dependent surface resistance and in turn affects the cryogenic thermal conduction problem. Integrated EM & thermal analysis of this difficult non-linear problem is now possible with the VORPAL finite-difference time-domain simulation tool. We highlight thermal benchmarking work with a complex HOM feed-through geometry, done in collaboration with researchers at the Thomas Jefferson National Accelerator Laboratory, and discuss upcoming design studies with this emerging tool. This work is part of an effort to generalize the VORPAL framework to include generalized PDE capabilities, for wider multi-physics capabilities in the accelerator, vacuum electronics, plasma processing and fusion R&D fields, and we will also discuss user interface and algorithmic upgrades which facilitate this emerging multiphysics capability.

D.N. Smithe, D. Karipides, P. Stoltz, G. Cheng, H. Wang

2011-03-01

455

EM Structure-Based Accelerators Working Group Summary  

NASA Astrophysics Data System (ADS)

This Working Group (WG) focused on EM Structure-Based Accelerators, which covers a broad area of mechanisms and experiments. Topics covered included dielectric wakefield accelerators (DWA), photonic bandgap accelerators (PBGA), inverse free electron lasers (IFEL), vacuum laser accelerators (VLA), other novel schemes, and supporting analysis and modeling. In addition, this WG was tasked at the Workshop with developing conceptual (strawman) designs for a 1-GeV accelerator system based upon any of the experimentally-proven approaches covered in this WG. Two strawmen designs were developed based upon IFELs and DWAs. The presentations given and strawmen designs indicate great progress has been made in many areas. Proof-of-principle experiments will occur shortly in PBGA and VLA. Other well-proven devices, such as IFELs, are becoming accepted as "workhorse" providers of microbunches.

Kimura, W. D.; Lidia, S. M.

2004-12-01

456

Benchmarking a derivative-free minimax optimizer for EM design  

NASA Astrophysics Data System (ADS)

The paper presents a model-based derivative-free minimax optimizer and a benchmarking methodology. The optimizer is dedicated to such simulation-based design scenarios, when a single simulation is time-consuming and not very accurate, and so when fast improvement of design is expected rather then high accuracy optimization. A benchmarking methodology is formulated to compare efficiency of optimizers in such scenarios. A set of electromagnetic (EM) designs, for which a design simulation involves solution of very large partial differential equations, is used to exemplify the methodology. Presented results demonstrate how accuracy requirements and computational budget change ranking of optimizers. The proposed optimizer is shown to provide competetively rapid and reliable initial design improvement for modest 5-10% tolerance, but for higher accuracy demands and larger computational budget other solvers become more competitive.

Opalski, Leszek J.

457

TrakEM2 software for neural circuit reconstruction.  

PubMed

A key challenge in neuroscience is the expeditious reconstruction of neuronal circuits. For model systems such as Drosophila and C. elegans, the limiting step is no longer the acquisition of imagery but the extraction of the circuit from images. For this purpose, we designed a software application, TrakEM2, that addresses the systematic reconstruction of neuronal circuits from large electron microscopical and optical image volumes. We address the challenges of image volume composition from individual, deformed images; of the reconstruction of neuronal arbors and annotation of synapses with fast manual and semi-automatic methods; and the management of large collections of both images and annotations. The output is a neural circuit of 3d arbors and synapses, encoded in NeuroML and other formats, ready for analysis. PMID:22723842

Cardona, Albert; Saalfeld, Stephan; Schindelin, Johannes; Arganda-Carreras, Ignacio; Preibisch, Stephan; Longair, Mark; Tomancak, Pavel; Hartenstein, Volker; Douglas, Rodney J

2012-01-01

458

EM-based measurement fusion for HRR radar centroid processing  

NASA Astrophysics Data System (ADS)

This paper develops a new algorithm for high range resolution (HRR) radar centroid processing for scenarios where there are closely spaced objects. For range distributed targets with multiple discrete scatterers, HRR radars will receive detections across multiple range bins. When the resolution is very high, and the target has significant extent, then it is likely that the detections will not occur in adjacent bins. For target tracking purposes, the multiple detections must be grouped and fused to create a single object report and a range centroid estimate is computed since the detections are range distributed. With discrete scatterer separated by multiple range bins, then when closely spaced objects are present there is uncertainty about which detections should be grouped together for fusion. This paper applies the EM algorithm to form a recursive measurement fusion algorithm that segments the data into object clusters while simultaneously forming a range centroid estimate with refined bearing and elevation estimates.

Slocumb, Benjamin J.; Blair, W. Dale

2002-08-01

459

Linear array implementation of the EM algorithm for PET image reconstruction  

SciTech Connect

The PET image reconstruction based on the EM algorithm has several attractive advantages over the conventional convolution back projection algorithms. However, the PET image reconstruction based on the EM algorithm is computationally burdensome for today`s single processor systems. In addition, a large memory is required for the storage of the image, projection data, and the probability matrix. Since the computations are easily divided into tasks executable in parallel, multiprocessor configurations are the ideal choice for fast execution of the EM algorithms. In tis study, the authors attempt to overcome these two problems by parallelizing the EM algorithm on a multiprocessor systems. The parallel EM algorithm on a linear array topology using the commercially available fast floating point digital signal processor (DSP) chips as the processing elements (PE`s) has been implemented. The performance of the EM algorithm on a 386/387 machine, IBM 6000 RISC workstation, and on the linear array system is discussed and compared. The results show that the computational speed performance of a linear array using 8 DSP chips as PE`s executing the EM image reconstruction algorithm is about 15.5 times better than that of the IBM 6000 RISC workstation. The novelty of the scheme is its simplicity. The linear array topology is expandable with a larger number of PE`s. The architecture is not dependant on the DSP chip chosen, and the substitution of the latest DSP chip is straightforward and could yield better speed performance.

Rajan, K.; Patnaik, L.M.; Ramakrishna, J. [Indian Institute of Science, Bangalore (India)] [Indian Institute of Science, Bangalore (India)

1995-08-01

460

DOE-EM privatization and the 2006 Plan: Principles for procurement policies and risk management  

SciTech Connect

The Department of Energy`s Office of Environmental Remediation and Waste Management (EM) has recently set in place programs to restructure the strategic planning mechanism that will drive its clean-up schedule, The 2006 Plan, and to create a new set of business relationships with private contractors that will reduce costs--privatization. Taken together, the 2006 Plan and privatization will challenge EM to create new business practices to recast its risk management policies to support these initiatives while ensuring that its responsibilities toward the environment, human health, and worker safety (ES and H) are maintained. This paper argues that the 2006 Plan has transformed EM`s traditional, bottoms-up approach based on technical dictates to a top-down approach based on management goals--a transformation from an engineering problem to an economic problem. The 2006 Plan evolved from EM`s Ten-Year Plan, and seeks to convert the largely open-ended planning approach previously undertaken by EM to a plan bounded by time and dollars. The plan emphasizes making tradeoffs and choosing activities that deliver the most clean-up for the dollar. It also recognizes that each major player--stakeholders, DOE, OMB and Congress--has distinct interests that must be resolved if the process is to succeed. This, in turn, has created the need for a corresponding transformation in risk management practices from compliance-driven to benefit/cost-driven.

Bjornstad, D.J.; Jones, D.W.; Duemmer, C.L.

1997-08-01

461

Ambient air quality effects of the 2008-2009 Halema`uma`u eruption on the Island of Hawai`i  

NASA Astrophysics Data System (ADS)

While the Halema`uma`u eruption has enlivened volcanologists with the rare opportunity to observe eruptive processes at Kilauea’s summit, it has also caused significant environmental impact on the Island of Hawai`i. Since the beginning of 2008, the combined SO2 emissions from the east rift zone (ERZ) and summit of Kilauea have increased by ~40% as compared to the 2003-2007 long-term average. However, emissions from Kilauea’s summit have increased ~6-fold, averaging 850 t/d during January 2008-August 2009. Although average emissions from the ERZ during this period have been 1-2 times that of the summit, the relative impact of summit emissions is disproportionately large due to the location of the vent and the plume dispersal pattern to downwind communities. Ambient air quality data show that federal standards have been exceeded frequently in various communities on the south half of the island. Between April 2008 and August 2009, primary health standards for SO2 and PM2.5 were exceeded on 41 and 19 occasions respectively in Pahala, located ~30 km downwind of the Kilauea summit under prevailing trade wind conditions. Pahala, which exceeded the SO2 annual standard for 2008, had not exceeded standards prior to the opening of the Halema`uma`u vent in March 2008. In July 2008, the U.S. Secretary of Agriculture designated Hawai`i County a primary natural disaster area due to agricultural losses from volcanic emissions. Many growers of exotic flower crops in the Ka`u district suffered irrecoverable losses. Coffee and macadamia nut farmers also reported damage to their fields. While some livestock farmers reported eye irritation in cattle, more significant damage was observed in the accelerated deterioration of galvanized fencing, gates, pipelines and other infrastructure. The increase in volcanic pollution has spurred health concerns. A rise in respiratory emergencies for visitors to Kilauea caldera in early 2008 led Hawai`i Volcanoes National Park to close areas downwind of the vent. Two recent health studies on the Island of Hawaii conducted prior to the 2008-2009 activity noted increased upper respiratory symptom prevalence in areas of persistent volcanic pollution. The current activity and exposure provides further opportunity to examine thresholds of human response. Local emergency response agencies were pressured to act quickly to address the air quality hazards. A variety of initial approaches led to an official policy of “shelter-in-place” during extreme air quality events. To date, interagency mitigation efforts have included providing Web-available near-real-time SO2 and PM data, developing an SO2 alert index, public education, supplying community fire stations and schools with SO2 monitoring equipment, surveying water quality in home-based drinking water catchment tanks, exploring forecast models, and working to install air handling systems for affected hospitals. While volcanic pollution has been an ongoing issue on the Island since the ERZ eruption became continuous in 1986, the current summit eruption has posed new challenges to Hawai`i residents, who must adapt to living with an active volcano.

Elias, T.; Sutton, A. J.; Kauahikaua, J. P.; Ray, J. D.; Babb, J. L.

2009-12-01

462

EMS Provider Assessment of Vehicle Damage Compared to a Professional Crash Reconstructionist  

PubMed Central

Objective To determine the accuracy of EMS provider assessments of motor vehicle damage, when compared to measurements made by a professional crash reconstructionist. Methods EMS providers caring for adult patients injured during a motor vehicle crash and transported to the regional trauma center in a midsized community were interviewed upon ED arrival. The interview collected provider estimates of crash mechanism of injury. For crashes that met a preset severity threshold, the vehicle’s owner was asked to consent to having a crash reconstructionist assess their vehicle. The assessment included measuring intrusion and external auto deformity. Vehicle damage was used to calculate change in velocity. Paired t-test and correlation were used to compare EMS estimates and investigator derived values. Results 91 vehicles were enrolled; of these 58 were inspected and 33 were excluded because the vehicle was not accessible. 6 vehicles had multiple patients. Therefore, a total of 68 EMS estimates were compared to the inspection findings. Patients were 46% male, 28% admitted to hospital, and 1% died. Mean EMS estimated deformity was 18” and mean measured was 14”. Mean EMS estimated intrusion was 5” and mean measured was 4”. EMS providers and the reconstructionist had 67% agreement for determination of external auto deformity (kappa 0.26), and 88% agreement for determination of intrusion (kappa 0.27) when the 1999 Field Triage Decision Scheme Criteria were applied. Mean EMS estimated speed prior to the crash was 48 mph±13 and mean reconstructionist estimated change in velocity was 18 mph±12 (correlation -0.45). EMS determined that 19 vehicles had rolled over while the investigator identified 18 (kappa 0.96). In 55 cases EMS and the investigator agreed on seatbelt use, for the remaining 13 cases there was disagreement (5) or the investigator was unable to make a determination (8) (kappa 0.40). Conclusions This study found that EMS providers are good at estimating rollover. Vehicle intrusion, deformity, and seatbelt use appear to be more difficult to estimate with only fair agreement with the crash reconstructionist. As expected, the EMS provider estimated speed prior to the crash does not appear to be a reasonable proxy for change in velocity. PMID:21815732

Lerner, E. Brooke; Cushman, Jeremy T.; Blatt, Alan; Lawrence, Richard; Shah, Manish N.; Swor, Robert; Brasel, Karen; Jurkovich, Gregory J.

2011-01-01

463

User's guide for the PWR LOCA analysis capability of the WRAP-EM system  

SciTech Connect

The Water Reactor Analysis Package (WRAP) has been expanded to provide the capability to analyze loss-of-coolant accidents (LOCAs) in both pressurized water reactors (PWRs) and boiling water reactors (BWRs) by using evaluation models (EMs). The input specifications for modules in the WRAP-EM system are presented in this document along with the JOSHUA input templates. This document, along with the WRAP user's guide, provides a step-by-step procedure for setting up a PWR data base for the WRAP-EM system. 12 refs.

Beranek, F; Gregory, M V

1980-02-01

464

EM Wake-Sleep Shiro.Ikeda@brain.riken.go.jp  

E-print Network

­EM Wake-Sleep ­ 21 2-1 Shiro.Ikeda@brain.riken.go.jp 1 (Latent Variable) 2 2.1 -5 -2.5 0 2.5 5 x+1), p(x; )) t+1 6 #12;3.3 Wake-Sleep EM G. Hinton EM Wake-Sleep [6] Helmholtz Helmholtz Helmholtz Helmholtz 6 M D q(y|x; ) p(x, y; ) 2 Wake-Sleep t+1 D M KL(q ,p )KL(p ,q ) t+1 t () ()() () t 7: Wake

Ikeda, Shiro

465

Investigating the source of contaminated plumes downstream of the Alborz Sharghi coal washing plant using EM34 conductivity data, VLF-EM and DC-resistivity geophysical methods  

NASA Astrophysics Data System (ADS)

Coal washing factories may create serious environmental problems due to pyrite oxidation and acid mine drainage generation from coal waste piles on nearby land. Infiltration of pyrite oxidation products through the porous materials of the coal waste pile by rainwater cause changes in the conductivity of underground materials and groundwater downstream of the pile. Electromagnetic and electrical methods are effective for investigation and monitoring of the contaminated plumes caused by coal waste piles and tailings impoundments. In order to investigate the environmental impact from a coal waste pile at the Alborz Sharghi coal washing plant, an EM34 ground conductivity meter was used on seven parallel lines in an E-W direction, downstream of the waste pile. Two-dimensional resistivity models obtained by the inversion of EM34 conductivity data identified conductive leachate plumes. In addition, quasi-3D inversion of EM34 data has confirmed the decreasing resistivity at depth due to the contaminated plumes. Comparison between EM34, VLF and DC-resistivity datasets, which were acquired for similar survey lines, agree well in identifying changes in the resistivity trend. The EM34 and DC-resistivity sections have greater similarity and better smoothness rather than those of the VLF model. Two-dimensional inversion models of these methods have shown some contaminated plumes with low resistivity.

Shiraz, Farzin Amirkhani; Ardejani, Faramarz Doulati; Moradzadeh, Ali; Arab-Amiri, Ali Reza

2013-01-01

466

Serodiagnosis of alveolar echinococcosis: detection of antibody against EM18 in patients and rodents.  

PubMed

An international collaborative study on echinococcosis has been carried out for the establishment of a simple means for differential serodiagnosis of alveolar echinococcosis (AE) from other parasitic diseases including cystic echinococcosis (CE). The main candidate epitope is Em18 (previously undescribed epitope of a low molecular weight protein of 18.5 kDa). Evaluation of the usefulness of Em18 is introduced in this review paper. Serum samples showing antibody response against Em18 are exclusively from AE. The predominant IgG subclass recognizing Em18 is IgG4 or IgG1 or IgG4 + IgG1 but never IgG2. There are good correlations between (1) the antibody response against Em18 and the presence of active lesions and (2) the antibody response against Em18 and the Em2-ELISA values. Em18 is, therefore, expected to be reasonably reliable and useful for differentiation of active AE from inactive AE. A new ELISA system using a partially purified Em18 enriched fraction (PP-Em 18/16-ELISA) has been evaluated for serodiagnosis of AE compared with Em2plus-ELISA. A total of 194 serum samples were examined: 127 sera from AE (79) and CE (48) in China where both AE and CE are endemic, 21 sera from CE in Australia where CE only exists, 28 sera from cysticercosis (21), paragonimiasis (5) or sparganasis (2) in Korea where no indigenous AE nor CE exists and 11 normal sera. Antibody levels by PP-Em18/16-ELISA were much higher in AE than in CE and it was also true for commercially available Em2plus-ELISA. Some of CE from China showed exceptionally higher levels of antibody in comparison with those of CE from Australia. It is suggested that these strongly positive cases of CE from China may have been exposed to both species of Echinococcus. Although most of sera from paragonimiasis showed high antibody levels by Emplus-ELISA, they were negative by PP-Em18/16-ELISA. Therefore, PP-Em18/16-ELISA is expected to be more reliable for differentiation of AE from CE and others especially in Asian countries where paragonimiasis is still not rare. Antibody responses in rodents naturally infected with E. multilocularis: Serum samples from the wild vole, Clethrionomys rufocanus bedfordiae, infected with E. multilocularis showed similar antibody responses as in AE patients, whereas those from Norway rats, Rattus norvegicus, showed almost none. The latter rodents were simultaneously infected with Taenia taeniaeformis but showed no antibody response against T. taeniaeformis either. Therefore, we speculate that Norway rats may only be infected with E. multilocularis under some immunosuppressed conditions or genetic unresponsiveness. It is stressed that Em18 is highly specific to E. multilocularis, and antibody response against Em18 is reasonably reliable for differentiation of AE from other helminthic infections by Western blot and ELISA in humans and may be useful for detection of domestic animals contaminated with E. multilocularis in the endemic area. PMID:9656361

Akira, I

1997-01-01