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1

Schistosomiasis control: praziquantel forever?  

PubMed

Since no vaccine exists against schistosomiasis and the molluscs acting as intermediate hosts are not easy to attack, chemotherapy is the main approach for schistosomiasis control. Praziquantel is currently the only available antischistosomal drug and it is distributed mainly through mass administration programs to millions of people every year. A number of positive features make praziquantel an excellent drug, especially with regard to safety, efficacy, cost and ease of distribution. A major flaw is its lack of efficacy against the immature stages of the parasite. In view of its massive and repeated use on large numbers of individuals, the development of drug resistance is a much feared possibility. The mechanism of action of praziquantel is still unclear, a fact that does not favor the development of derivatives or alternatives. A large number of compounds have been tested as potential antischistosomal agents. Some of them are promising, but none so far represents a suitable substitute or adjunct to praziquantel. The research of new antischistosomal compounds is an imperative and urgent matter. PMID:24955523

Cioli, Donato; Pica-Mattoccia, Livia; Basso, Annalisa; Guidi, Alessandra

2014-06-01

2

Uma Estratégia para a Visualização do Céu e seus Elementos em Jogos  

Microsoft Academic Search

Resumo Uma visualização convincente do céu e seus elementos (nuvens, sol, lua, estrelas) é fundamental para agregar realismo aos jogos que usam cenários em ambientes externos. Como uma simulação precisa desses efeitos pode ser computacionalmente muito cara, muitos jogos empregam artifícios, visualizando o céu como texturas mapeadas em esferas e caixas envolventes. Neste trabalho, apresentamos uma estratégia simples para simular

MARCIO PEREIRA DE ARAUJO; WALDEMAR CELES

3

Santo Daime : um sacramento vivo, uma religião em formação.  

E-print Network

??Tese (doutorado)—Universidade de Brasília, Instituto de Ciências Humanas, 2007. A Ayahuasca é uma substância psicoativa formada pela deccoção do cipó Banisteriopsis caapi, conhecido como Jagube,… (more)

Oliveira, Isabela

2007-01-01

4

Praziquantel Treatment in Trematode and Cestode Infections: An Update  

PubMed Central

Status and emerging issues in the use of praziquantel for treatment of human trematode and cestode infections are briefly reviewed. Since praziquantel was first introduced as a broadspectrum anthelmintic in 1975, innumerable articles describing its successful use in the treatment of the majority of human-infecting trematodes and cestodes have been published. The target trematode and cestode diseases include schistosomiasis, clonorchiasis and opisthorchiasis, paragonimiasis, heterophyidiasis, echinostomiasis, fasciolopsiasis, neodiplostomiasis, gymnophalloidiasis, taeniases, diphyllobothriasis, hymenolepiasis, and cysticercosis. However, Fasciola hepatica and Fasciola gigantica infections are refractory to praziquantel, for which triclabendazole, an alternative drug, is necessary. In addition, larval cestode infections, particularly hydatid disease and sparganosis, are not successfully treated by praziquantel. The precise mechanism of action of praziquantel is still poorly understood. There are also emerging problems with praziquantel treatment, which include the appearance of drug resistance in the treatment of Schistosoma mansoni and possibly Schistosoma japonicum, along with allergic or hypersensitivity reactions against praziquantel treatment. To cope with and overcome these problems, combined use of drugs, i.e., praziquantel and other newly introduced compounds such as triclabendazole, artemisinins, and tribendimidine, is being tried. PMID:24265948

2013-01-01

5

Praziquantel treatment in trematode and cestode infections: an update.  

PubMed

Status and emerging issues in the use of praziquantel for treatment of human trematode and cestode infections are briefly reviewed. Since praziquantel was first introduced as a broadspectrum anthelmintic in 1975, innumerable articles describing its successful use in the treatment of the majority of human-infecting trematodes and cestodes have been published. The target trematode and cestode diseases include schistosomiasis, clonorchiasis and opisthorchiasis, paragonimiasis, heterophyidiasis, echinostomiasis, fasciolopsiasis, neodiplostomiasis, gymnophalloidiasis, taeniases, diphyllobothriasis, hymenolepiasis, and cysticercosis. However, Fasciola hepatica and Fasciola gigantica infections are refractory to praziquantel, for which triclabendazole, an alternative drug, is necessary. In addition, larval cestode infections, particularly hydatid disease and sparganosis, are not successfully treated by praziquantel. The precise mechanism of action of praziquantel is still poorly understood. There are also emerging problems with praziquantel treatment, which include the appearance of drug resistance in the treatment of Schistosoma mansoni and possibly Schistosoma japonicum, along with allergic or hypersensitivity reactions against praziquantel treatment. To cope with and overcome these problems, combined use of drugs, i.e., praziquantel and other newly introduced compounds such as triclabendazole, artemisinins, and tribendimidine, is being tried. PMID:24265948

Chai, Jong-Yil

2013-03-01

6

Notas para uma Avaliação do Discurso Marxista em Douglass North  

Microsoft Academic Search

A partir da publicação do livro Institutions, Institutional Change and Economic Performance em 1990 e da obtenção do Nobel em 1993, as contribuições de Douglass North parecem ter entrado definitivamente no debate sobre a questão do desenvolvimento das economias no longo prazo. Muito se discute atualmente sobre a natureza da obra de North, mais especificamente sobre o grau de neoclassicismo

Gabriel Galípolo; Paulo Gala; Danilo Araujo Fernandes

2008-01-01

7

Queda dos homicídios em São Paulo, Brasil: uma análise descritiva  

PubMed Central

Objetivo Descrever a evolução da mortalidade por homicídios no Município de São Paulo segundo tipo de arma, sexo, raça ou cor, idade e áreas de exclusão/inclusão social entre 1996 e 2008. Métodos Estudo ecológico de série temporal. Os dados sobre óbitos ocorridos no Município foram coletados da base de dados do Programa de Aprimoramento das Informações sobre Mortalidade, seguindo a Classificação Internacional de Doenças, Décima Revisão (CID-10). Foram calculadas as taxas de mortalidade por homicídio (TMH) para a população total, por sexo, raça ou cor, faixa etária, tipo de arma e área de exclusão/inclusão social. As TMH foram padronizadas por idade pelo método direto. Foram calculados os percentuais de variação no período estudado. Para as áreas de exclusão/inclusão social foram calculados os riscos relativos de morte por homicídio. Resultados As TMH apresentaram queda de 73,7% entre 2001 e 2008. Foi observada redução da TMH em todos os grupos analisados, mais pronunciada em homens (?74,5%), jovens de 15 a 24 anos (?78,0%) e moradores de áreas de exclusão social extrema (?79,3%). A redução ocorreu, sobretudo, nos homicídios cometidos com armas de fogo (?74,1%). O risco relativo de morte por homicídio nas áreas de exclusão extrema (tendo como referência áreas com algum grau de exclusão social) foi de 2,77 em 1996, 3,9 em 2001 e 2,13 em 2008. Nas áreas de alta exclusão social, o risco relativo foi de 2,07 em 1996 e 1,96 em 2008. Conclusões Para compreender a redução dos homicídios no Município, é importante considerar macrodeterminantes que atingem todo o Município e todos os subgrupos populacionais e microdeterminantes que atuam localmente, influenciando de forma diferenciada os homicídios com armas de fogo e os homicídios na população jovem, no sexo masculino e em residentes em áreas de alta exclusão social. PMID:21390415

Peres, Maria Fernanda Tourinho; Vicentin, Diego; Nery, Marcelo Batista; de Lima, Renato Sérgio; de Souza, Edinilsa Ramos; Cerda, Magdalena; Cardia, Nancy; Adorno, e Sérgio

2012-01-01

8

ARALES DE LAGOAS EM UMA ÁREA DO SEMI-ÁRIDO BAIANO  

Microsoft Academic Search

RESUMO — O presente trabalho trata das espécies de Arales ocorrentes em lagoas de uma área do semi-árido baiano. A ordem apresenta, no local, duas famílias com cinco espécies: Lemna valdiviana Phil., Lemna aequinoctialis Welwitsch, Wolffiella lingulata (Hegelm.) Hegelm. e Wolffia columbiana Karsten (LEMNACEAE) e Pistia stratiotes L. (ARACEAE). PALAVRAS-CHAVE: Arales; plantas aquáticas; Lemnaceae; Araceae. ABSTRACT — This paper presents

Márcia Gonçalves Bezerra; Flávio França

9

21 CFR 520.1200 - Ivermectin, fenbendazole, and praziquantel tablets.  

Code of Federal Regulations, 2013 CFR

...100 mg/kg fenbendazole, and 5 mg/kg praziquantel. (2) Indications for use . For the treatment and control of adult Toxocara canis (roundworm), Ancylostoma caninum (hookworm), Trichuris vulpis (whipworm), and Dipylidium caninum...

2013-04-01

10

21 CFR 520.1200 - Ivermectin, fenbendazole, and praziquantel tablets.  

...100 mg/kg fenbendazole, and 5 mg/kg praziquantel. (2) Indications for use. For the treatment and control of adult Toxocara canis (roundworm), Ancylostoma caninum (hookworm), Trichuris vulpis (whipworm), and Dipylidium caninum...

2014-04-01

11

21 CFR 520.1200 - Ivermectin, fenbendazole, and praziquantel tablets.  

Code of Federal Regulations, 2012 CFR

...100 mg/kg fenbendazole, and 5 mg/kg praziquantel. (2) Indications for use . For the treatment and control of adult Toxocara canis (roundworm), Ancylostoma caninum (hookworm), Trichuris vulpis (whipworm), and Dipylidium caninum...

2012-04-01

12

21 CFR 520.1200 - Ivermectin, fenbendazole, and praziquantel tablets.  

Code of Federal Regulations, 2011 CFR

...100 mg/kg fenbendazole, and 5 mg/kg praziquantel. (2) Indications for use . For the treatment and control of adult Toxocara canis (roundworm), Ancylostoma caninum (hookworm), Trichuris vulpis (whipworm), and Dipylidium caninum...

2011-04-01

13

Acute toxicity of praziquantel (an anthelmintic) to grass carp and golden shiners  

Technology Transfer Automated Retrieval System (TEKTRAN)

Praziquantel is an anthelmintic that can be applied to the water to kill tapeworm and trematode parasites in fish. Effective praziquantel treatment rates have been determined but there is little information on the toxicity of this chemical to fish hosts of the parasites. Acute praziquantel toxicit...

14

Efficacy of praziquantel against Schistosoma mansoni in northern Senegal  

Microsoft Academic Search

Two treatments with praziquantel (PZQ) 40 mg\\/kg, 40 d apart, were given to individuals in a recently established (< 6 years) Schistosoma mansoni focus in the Senegal River Basin (SKB). Efficacy of treatment was evaluated 4 weeks after each treatment. Among 130 individuals who provided stool samples on days 0, 118 and 153 and were treated on days 85 and

Michel Picquet; Jozef Vercruysse; Darren J. Shaw; Mamadou Diop; Abdoulaye Ly

1998-01-01

15

21 CFR 524.775 - Emodepside and praziquantel.  

Code of Federal Regulations, 2013 CFR

...ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS OPHTHALMIC AND TOPICAL DOSAGE FORM NEW ANIMAL DRUGS § 524.775 Emodepside and...45 mg/lb (12 mg/kg) praziquantel applied as a single topical dose. (2) Indications for use . For the treatment...

2013-04-01

16

21 CFR 524.775 - Emodepside and praziquantel.  

Code of Federal Regulations, 2012 CFR

...ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS OPHTHALMIC AND TOPICAL DOSAGE FORM NEW ANIMAL DRUGS § 524.775 Emodepside and...45 mg/lb (12 mg/kg) praziquantel applied as a single topical dose. (2) Indications for use . For the treatment...

2012-04-01

17

21 CFR 524.775 - Emodepside and praziquantel.  

Code of Federal Regulations, 2011 CFR

...ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS OPHTHALMIC AND TOPICAL DOSAGE FORM NEW ANIMAL DRUGS § 524.775 Emodepside and...45 mg/lb (12 mg/kg) praziquantel applied as a single topical dose. (2) Indications for use . For the treatment...

2011-04-01

18

21 CFR 524.775 - Emodepside and praziquantel.  

...ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS OPHTHALMIC AND TOPICAL DOSAGE FORM NEW ANIMAL DRUGS § 524.775 Emodepside and...45 mg/lb (12 mg/kg) praziquantel applied as a single topical dose. (2) Indications for use. For the treatment...

2014-04-01

19

Why is the drug praziquantel effective in the treatment of parasitic flatworms? Praziquantel (PZQ) is the drug most commonly used in humans and livestock to  

E-print Network

Why is the drug praziquantel effective in the treatment of parasitic flatworms? Praziquantel (PZQ) is the drug most commonly used in humans and livestock to fight the disease schistosomiasis, an infection of the host by parasitic worms of the genus Schistosoma. While it has been used effectively for several

Minnesota, University of

20

Praziquantel failure in the treatment of Fasciola hepatica  

PubMed Central

A case of human fascioliasis is presented in which the patient remained symptomatic after treatment with praziquantel and other agents but eventually responded to bithionol. The difficulties in finding an efficacious and tolerable drug therapy for this condition are reviewed with reference to the life cycle and pathogenesis of the parasite. It is concluded that while bithionol remains the current drug of choice, triclabendazole may play a dominant role in the near future. PMID:22451761

Patrick, David Michael; Isaac-Renton, Judith

1992-01-01

21

Evoluindo para uma Arquitetura de Groupware Baseada em Componentes: o Estudo de Caso do Learningware AulaNet  

E-print Network

Evoluindo para uma Arquitetura de Groupware Baseada em Componentes: o Estudo de Caso do}@inf.puc-rio.br;abraposo@tecgraf.puc-rio.br Abstract. Groupware must be flexible in order to satisfy the different characteristics and the continuous as a basis for building different types of groupware. It ensues in the new AulaNet architecture

Barbosa, Alberto

22

THE ACUTE TOXICITY OF PRAZIQUANTEL TO GRASS CARP AND GOLDEN SHINERS  

Technology Transfer Automated Retrieval System (TEKTRAN)

Acute praziquantel toxicity and no observable effect concentrations (NOEC), were determined in the laboratory for grass carp and golden shiners, two commercially raised cyprinids known to harbor Asian tapeworm Bothriocephalus acheilognathi. Praziquantel is an anthelmintic used to treat fish with ta...

23

Is there a reduced sensitivity of dihydroartemisinin against praziquantel-resistant Schistosoma japonicum?  

PubMed

Praziquantel is currently the only drug of choice for the treatment of human schistosomiases. However, it has been proved that Schistosoma japonicum subjected to drug pressure may develop resistance to praziquantel. To evaluate the efficacy of dihydroartemisinin against praziquantel-resistant S. japonicum, mice infected with a praziquantel-resistant isolate and a praziquantel-susceptible isolate of S. japonicum were treated with dihydroartemisinin at a single oral dose of 300 mg/kg given once on each of 35-36 post-infection days, while infected but untreated mice served as controls. All mice were sacrificed 50 days post-infection, and the worm burden reductions were estimated. Administration of dihydroartemisinin at a single oral dose of 300 mg/kg on each of 35-36 post-infection days reduced total worm burdens of 69.8% and female worm burdens of 86% in mice infected with the praziquantel-susceptible isolate, and total worm burdens of 66.1% and female worm burdens of 85.1% in mice infected with the praziquantel-resistant isolate (both P values > 0.05). It is concluded that the sensitivity of artemisinin derivative dihydroartemisinin does not reduce in praziquantel-resistant S. japonicum. PMID:24146208

Wang, Wei; Li, Hong-Jun; Qu, Guo-Li; Xing, Yun-Tian; Yang, Zhen-Kun; Dai, Jian-Rong; Liang, You-Sheng

2014-01-01

24

Use of praziquantel for the control of Moniezia expansa in lambs.  

PubMed

The efficacy of a drench containing praziquantel in combination with levamisole was evaluated in four trials performed in the 1990-91 and 1992-93 seasons in the Waikato Region of New Zealand. The trials involved 93 naturally infected lambs and compared the efficacy of a 3.75 mg/kg praziquantel 7.5mg/kg levamisole drench against Moniezia expansa, with albendazole, an albendazole-levamisole combination and oxyclozanide-levamisole combination in controlled trials. There was no significant reduction in the number of Moniezia expansa scoleces or proglottids in the control, albendazole and albendazole-levamisole groups. Oxyclozanide gave a high clearance of proglottids, but a 28% reduction of scoleces. The praziquantel-levamisole combination demonstrated complete removal of segments in all trials, and of scoleces in two trials. One scolex was found in each of the two other trials. The combination was also tested for efficacy against nematode parasites. Total worm counts indicated that levamisole in the praziquantel-levamisole combination drench retained its efficacy. The economic benefits of the use of the praziquantel-levamisole drench were investigated. This trial compared the liveweight gains of three groups of 100 lambs treated twice 4 weeks apart with either levamisole or with the praziquantel-levamisole combination or acting as untreated control group. The group treated with the praziquantel-levamisole combination gained significantly more weight in both 4-week periods and overall, when compared with either the control or levamisole treated animals. PMID:16031907

Southworth, J; Harvey, C; Larson, S

1996-06-01

25

Representaes Qunticas no Espao de Fases Uma funo de onda abstrata | > um vetor em um espao de Hilbert. Esse vetor pode ser expresso  

E-print Network

espaço de Hilbert. Esse vetor pode ser expresso em termos de uma infinidade de representações ortonormais. Assim nenhuma função das coordenadas (q,p) pode ser definida de forma a ser interpretada como" dado o Princípio da Incerteza. Uma excelente revisão desse formalismo pode ser encontrado em [13,14]. 2

de Aguiar, Marcus A. M.

26

Safety of concurrent treatment of dogs with fluralaner (Bravecto¿) and milbemycin oxime - praziquantel.  

PubMed

BackgroundFluralaner (Bravecto¿; Merck/MSD Animal Health) is a novel systemic ectoparasiticide for dogs providing long-acting flea and tick control after a single oral dose. Milbemycin oxime and praziquantel are routinely used to control Dirofilaria immitis and intestinal worm infections in dogs. The safety of concurrent use of fluralaner and a commercially available milbemycin oxime plus praziquantel combination tablet, in particular with regard to gastrointestinal symptoms, was investigated using oral doses at or above the maximum recommended rates.FindingsSome minor and transient clinical findings were observed during the study period; however, none of these was considered to be related to concurrent treatment with fluralaner and milbemycin oxime plus praziquantel, or to the use of either product alone.ConclusionsConcurrent treatment with fluralaner, milbemycin oxime and praziquantel is well tolerated in dogs. PMID:25315498

Walther, Feli M; Fisara, Petr; Allan, Mark J; Roepke, Rainer; Nuernberger, Martin C

2014-10-15

27

Comparison of albendazole, mebendazole and praziquantel chemotherapy of Echinococcus multilocularis in a gerbil model  

Microsoft Academic Search

The efficacy of albendazole (50 mg\\/kg\\/d), mebendazole (50 mg\\/kg\\/d) and praziquantel (500 mg\\/kg\\/d) against established intraperitoneal infections of Echinococcus multilocularis in gerbils was compared by monitoring parasite weight and making ultrastructural observations on treated and untreated material. Praziquantel was the most active protoscolicidal agent, reducing protoscolex viability to less than 2%, although it did not inhibit cyst growth. Albendazole was

D H Taylor; D L Morris; D Reffin; K S Richards

1989-01-01

28

Use of praziquantel for the control of Moniezia expansa in lambs  

Microsoft Academic Search

The efficacy of a drench containing praziquantel in combination with levamisole was evaluated in four trials performed in the 1990–91 and 1992–93 seasons in the Waikato Region of New Zealand. The trials involved 93 naturally infected lambs and compared the efficacy of a 3.75 mg\\/kg praziquantel – 7.5mg\\/kg levamisole drench against Moniezia expansa, with albendazole, an albendazole-levamisole combination and oxyclozanide-levamisole

J. Southworth; C. Harvey; S. Larson

1996-01-01

29

O CONCEITO DE EMANCIPAÇÃO COMO FUNDAMENTO PARA UMA TEORIA DA EDUCAÇÃO EM JÜRGEN HABERMAS  

Microsoft Academic Search

Neste breve artigo pretendemos apresentar elementos que possam ser sugestivos e indicativos para a fundamentação de uma teoria da educação a partir da compreensão do processo de esclarecimento enquanto processo de emancipação do homem na sociedade contemporânea. Sabemos que Jürgen Habermas propõe o recurso ao entendimento mútuo como meio para se chegar a um entendimento e se obter um consenso,

Bartolomeu Leite da Silva

2010-01-01

30

Use of praziquantel for clinical treatment and morbidity control of schistosomiasis japonica in China: a review of 30 years’ experience  

Microsoft Academic Search

Chemotherapy is widely acknowledged as the most important, rapid and cost-effective method of reducing morbidity due to schistosome infections. The discovery of praziquantel in the 1970s has been a breakthrough for treatment of patients infected with schistosomes, including Schistosoma japonicum in China, and entire communities at risk of schistosomiasis. Praziquantel is usually administered in a single oral dose and has

Chen Ming-Gang

2005-01-01

31

Efficacy of 6-, 12-, and 24-h praziquantel bath treatments against Asian tapeworm Bothriocephalus acheilognathi in grass carp  

Technology Transfer Automated Retrieval System (TEKTRAN)

Praziquantel is an effective antihelmintic that has been used in dogs and cats as a de-wormer. It has also been used successfully against tapeworms and trematodes in fish. The current study tested the efficacy of praziquantel bath treatments at various concentrations (0.187, 0.375, 0.75, 1.5, 3.0,...

32

Voc conseguiu. A partir de agora voc vai estudar, pesquisar e conviver em uma universidade pblica,  

E-print Network

matrícula e a senha. Na BU o calouro vai encontrar 305 mil exemplares de livros e 5000 assinatu- ras de diversos periódicos, entre revis- tas e jornais especializados. Podem ser pegos até dez livros de uma só livro ­ por isso, é melhor não vacilar e entregar no dia. O aluno pode ficar com os livros por mais 15

Floeter, Sergio Ricardo

33

Pharmacokinetics of praziquantel in healthy volunteers and patients with schistosomiasis.  

PubMed

The pharmacokinetics of a novel praziquantel preparation (Distocide) were investigated in Sudanese patients with hepatosplenic schistosomiasis and in healthy volunteers, and compared with those of Biltricide. The results of the first study indicated greater (P less than 0.05) plasma concentrations of Biltricide at 1.5, 2, 3 and 5 h after administration than with Distocide; plasma elimination half-lives (t 1/2) were not significantly different. In patients with hepatosplenic schistosomiasis, higher plasma levels of Distocide were noted (P less than 0.05 at 8 h) compared to healthy controls; however, due to wide inter-individual variations, there were no significant differences in maximum plasma concentration, time to maximum plasma concentration, area under the plasma concentration curve (AUC), volume of distribution, or clearance; t 1/2 was greater (P less than 0.05) in patients (11.9 +/- 5.4 h) than controls (2.3 +/- 0.4 h). In the presence of food, higher plasma concentrations of Distocide occurred compared to the fasting state; AUCs were greater (P less than 0.01) in both food groups, although the values of t 1/2 were shorter. The lower plasma levels and longer duration of action of Distocide may be advantageous in reducing side effects and prolonging exposure of the schistosomes to the drug. PMID:2124391

Mandour, M E; el Turabi, H; Homeida, M M; el Sadig, T; Ali, H M; Bennett, J L; Leahey, W J; Harron, D W

1990-01-01

34

O pragmatismo em economia : bases filosóficas para uma interpretação do discurso econômico  

Microsoft Academic Search

O trabalho tem por objetivo trazer elementos da corrente filosófica do pragmatismo para a discussão metodológica em economia, particularmente no que diz respeito a teoria da verdade e suas implicações para o debate epistemológico. Após apresentar as contribuições dos pioneiros do pragmatismo William James, John Dewey e Charles S. Peirce e discutir aspectos da obra de W. Quine e Richard

Paulo Sérgio de Oliveira Simões Gala; Danilo Fernandes Araújo; José Márcio Rego

2004-01-01

35

Tend^encias em Matematica Aplicada e Computacional, 3, No. 1 (2002), 41-50. c Uma Publicac~ao da Sociedade Brasileira de Matematica Aplicada e Computacional.  

E-print Network

Tend^encias em Matem´atica Aplicada e Computacional, 3, No. 1 (2002), 41-50. c Uma Publica¸c~ao da Sociedade Brasileira de Matem´atica Aplicada e Computacional. M´etodos de Pontos Interiores Aplicados diferentes graus a esparsidade do problema. O desempenho computacional dos m´etodos ´e comparado para dados

Oliveira, Aurélio R. L.

36

Praziquantel sensitivity of Kenyan Schistosoma mansoni isolates and the generation of a laboratory strain with reduced susceptibility to the drug.  

PubMed

Schistosomiasis is a neglected tropical disease caused by blood-dwelling flukes of the genus Schistosoma. While the disease may affect as many as 249 million people, treatment largely relies on a single drug, praziquantel. The near exclusive use of this drug for such a prevalent disease has led to concerns regarding the potential for drug resistance to arise and the effect this would have on affected populations. In this study, we use an in vitro assay of drug sensitivity to test the effect of praziquantel on miracidia hatched from eggs obtained from fecal samples of Kenyan adult car washers and sand harvesters as well as school children. Whereas in a previous study we found the car washers and sand harvesters to harbor Schistosoma mansoni with reduced praziquantel sensitivity, we found no evidence for the presence of such strains in any of the groups tested here. Using miracidia derived from seven car washers to infect snails, we used the shed cercariae to establish a strain of S. mansoni with significantly reduced praziquantel sensitivity in mice. This was achieved within 5 generations by administering increasing doses of praziquantel to the infected mice until the parasites could withstand a normally lethal dose. This result indicates that while the threat of praziquantel resistance may have diminished in the Kenyan populations tested here, there is a strong likelihood it could return if sufficient praziquantel pressure is applied. PMID:25516840

Mwangi, Ibrahim N; Sanchez, Melissa C; Mkoji, Gerald M; Agola, Lelo E; Runo, Steven M; Cupit, Pauline M; Cunningham, Charles

2014-12-01

37

Praziquantel Affects the Regulatory Myosin Light Chain of Schistosoma mansoni?  

PubMed Central

Praziquantel (PZQ) is the drug of choice for schistosomiasis and probably is the only highly effective drug currently available for treating schistosomiasis-infected individuals. The mode of action of PZQ involves increasing the calcium uptake of the parasite, resulting in tegumental damage and death of the parasite. Despite its remarkable function, the target of PZQ has not been identified yet. To begin to understand where PZQ acts, in this study we expressed the cDNA library of Schistosoma mansoni on the surface of T7 bacteriophages and screened this library with labeled PZQ. This procedure identified a clone that strongly bound to PZQ. Subsequent DNA analysis of inserts showed that the clone coded for regulatory myosin light chain protein. The gene was then cloned, and recombinant S. mansoni myosin light chain (SmMLC) was expressed. Immunoblot analysis using antibodies raised to recombinant SmMLC (rSmMLC) showed that SmMLC is abundantly expressed in schistosomula and adult stages compared to the amount in cercarial stages. In vitro analyses also confirmed that PZQ strongly binds to rSmMLC. Further, peptide mapping studies showed that PZQ binds to amino acids 46 to 76 of SmMLC. Immunoprecipitation analysis confirmed that SmMLC is phosphorylated in vivo upon exposure to PZQ. Interestingly, significant levels of anti-SmMLC antibodies were present in vaccinated mice compared to the amount in infected mice, suggesting that SmMLC may be a potential target for protective immunity in schistosomiasis. These findings suggest that PZQ affects SmMLC function, and this may have a role in PZQ action. PMID:19104008

Gnanasekar, Munirathinam; Salunkhe, Ashok M.; Mallia, A. Krishna; He, Yi Xun; Kalyanasundaram, Ramaswamy

2009-01-01

38

Uma Comparação entre Técnicas de Propagação de Erros em Astrofísica: Monte Carlo x Bootstrap  

NASA Astrophysics Data System (ADS)

Neste trabalho é feito um estudo comparativo entre dois algoritmos numéricos usados para propagação de erros em dados experimentais. Um deles é conhecido por Método de Monte carlo e o outro por Método de Bootstrap. Recentemente, Dhullon & Watson argüiram que a aplicação do método de Monte Carlo introduz ruído nos dados, e propuseram então a utilização do Bootstrap como alternativa capaz de produzir resultados superiores. O objetivo deste trabalho é testar a validade dessa afirmação. As duas técnicas foram aplicadas a três problemas diferentes: o ajsute de modelos de emissão LTE simples e atmosfera estelar a espectros estelares observados e o ajuste de curvas de luz de eclipses de Variáveis Cataclísmicas para a detemrinação da distribuição radial de brilho dos seus discos de acréscimo. Os métodos foram testados quanto à sua robusteza, ou seja, a capacidade de prover resultados coerentes enre si. Além disso, as soluções dos métodos foram comparadas. Os resultados indicam que não existe evidência de superioridade de um métodos em relação ao outro.

Zabot, Alexandre; Baptista, Raymundo

2005-07-01

39

Effect of Chemotherapy with Praziquantel on the Production of Cytokines and Morbidity Associated with Schistosomiasis Mansoni  

Microsoft Academic Search

The objective of the present study was to test the hypothesis that treatment of schistosomiasis mansoni with praziquantel can alter significantly the immune response of patients and generate a reversal of the level of fibrosis. Peripheral blood mononuclear cell (PBMC) samples were collected from, and abdominal ultrasound examinations conducted on, volunteers infected with Schistosoma mansoni and living in an area

P. Martins-Leite; G. Gazzinelli; L. F. Alves-Oliveira; A. Gazzinelli; L. C. C. Malaquias; R. Correa-Oliveira; A. Teixeira-Carvalho; A. M. S. Silveira

2008-01-01

40

75 FR 54018 - Oral Dosage Form New Animal Drugs; Praziquantel and Pyrantel  

Federal Register 2010, 2011, 2012, 2013

The Food and Drug Administration (FDA) is amending the animal drug regulations to reflect approval of a supplemental new animal drug application (NADA) filed by Bayer HealthCare LLC. The supplement provides for two new sizes of praziquantel and pyrantel pamoate tablets used in cats and kittens for the removal of various internal parasites and for a revised kitten age and weight...

2010-09-03

41

Efficacy of artemether and artesunate in mice infected with praziquantel non-susceptible isolate of Schistosoma japonicum.  

PubMed

Praziquantel is currently the only drug of choice for the treatment of human Schistosoma japonicum infections, and praziquantel-based chemotherapy has been proved to be generally effective to control the morbidity and reduce the prevalence and intensity of S. japonicum infections. However, the potential emergence of praziquantel resistance in S. japonicum seriously threatens the elimination of this neglected tropical disease in China. The purpose of this study was designed, in mouse animals, to evaluate the in vivo efficacy of artemether and artesunate against praziquantel non-susceptible S. japonicum. Mice infected with a praziquantel non-susceptible isolate and a praziquantel-susceptible isolate of S. japonicum were treated with artemether and artesunate at a single oral dose of 300 mg/kg given once on each of days 7-8 and 35-36 post-infection to assess the efficacy against juvenile and adult worms. Administration with artemether and artesunate at a single oral dose of 300 mg/kg on each of days 7-8 post-infection resulted in total worm burden reductions of 72.8 and 73.5% in mice infected with praziquantel-susceptible S. japonicum, and 77.9 and 74.1% in mice infected with the non-susceptible isolate (both P values >0.05), while the same treatments given on days 35-36 post-infection reduced total worm burdens by 71.4 and 69.6% in mice infected with the susceptible isolate, and 75.3 and 69.6% in mice infected with the non-susceptible parasite (both P values >0.05). It is concluded that there is no evidence for reduced susceptibility of artemether and artesunate in praziquantel non-susceptible S. japonicum. PMID:24326467

Wang, Wei; Li, Tian-Yu; Ji, Yuan; Qu, Guo-Li; Qian, Yi-Li; Li, Hong-Jun; Dai, Jian-Rong; Liang, You-Sheng

2014-03-01

42

Pharmacokinetic study of praziquantel administered alone and in combination with cimetidine in a single-day therapeutic regimen.  

PubMed Central

A brief therapeutic regimen of praziquantel, reduced to a single day, has been effective for treatment of neurocysticercosis. To study its pharmacokinetic characteristics, levels of praziquantel in plasma were determined for eight healthy volunteers after the administration of three oral doses of 25 mg/kg of body weight given at 2-h intervals, alone and with the simultaneous administration of cimetidine. Each volunteer received both regimens in a randomized crossover design. Blood samples were taken during a period of 12 h, and praziquantel concentration was measured by high-performance liquid chromatography. Levels of praziquantel in plasma remained above 300 ng/ml during a period of 12 h; they increased 100% when cimetidine was jointly administered. Compared with other regimens, the high levels obtained and the longer duration of action seem to be advantageous in prolonging the exposure of the parasites to the drug and support previous clinical experience showing that the treatment of neurocysticercosis with praziquantel can be reduced from 2 weeks to 1 day with the drug still retaining its cysticidal properties. Moreover, simultaneous administration of praziquantel and cimetidine could improve further the efficacy of the single-day therapy for cysticercosis and other parasitic diseases, such as schistosomiasis. PMID:9174180

Jung, H; Medina, R; Castro, N; Corona, T; Sotelo, J

1997-01-01

43

Serological changes observed in horses infected with Anoplocephala perfoliata after treatment with praziquantel and natural reinfection.  

PubMed

The serological changes in two groups of horses known to be harbouring Anoplocephala perfoliata were studied; 12 were treated with 1.5 mg/kg praziquantel and 200 microg/kg ivermectin, and 14 were treated with 200 microg/kg ivermectin. Serological and faecal analyses were carried out on each animal at intervals for 758 days. The titres of antibodies specific for A perfoliata decreased from the day of treatment to day 28 in both groups, and continued to decrease in the group treated with praziquantel and ivermectin, with the first significant decrease from the other group at day 121. From day 151 to day 295 the first significant increase in antibody levels in the group treated with both drugs was observed; no A perfoliata eggs were detected in the faeces of these animals until day 295 when five of the 10 were positive. PMID:18192657

Abbott, J B; Mellor, D J; Barrett, E J; Proudman, C J; Love, S

2008-01-12

44

Activity of praziquantel (0.5 mg kg-1) against Anoplocephala perfoliata (Cestoda) in equids.  

PubMed

Praziquantel injectable formulation was administered at 0.5 mg k-1 per os to 24 equids naturally infected with 1-183 (average 40) Anoplocephala perfoliata. Drug activity was evaluated by a modified critical test method with necropsy 24 h after treatment. There was variable efficacy of 0-100% (aggregate average 85%); for 18 equids, 93-100%, for three equids, 70-85%, and for three equids, 0-20%. PMID:7732649

Lyons, E T; Tolliver, S C; Stamper, S; Drudge, J H; Granstrom, D E; Collins, S S

1995-01-01

45

Failure of repeated treatment with praziquantel and arthemeter in four patients with acute schistosomiasis.  

PubMed

Schistosomiasis is on the rise but still difficult to treat in international travelers; it should be suspected in patients returning from endemic areas. Praziquantel (PZQ) is not effective and may aggravate symptoms. More recently, combination treatment with artemisinin derivatives have shown promising results. We report four cases of acute schistosomiasis (AS) in which several courses of combined therapy had been necessary to obtain negative serology. PMID:24455977

Praticò, Liliana; Mariani, Bianca; Brunetti, Enrico; Maserati, Roberta; Bruno, Antonella; Novati, Stefano; Chichino, Guido

2014-01-01

46

Entrevista: " uma disciplina fundamental.  

E-print Network

· Entrevista: "� uma disciplina fundamental. Como a filosofia" #12;"A matemática é uma disciplina fundamental. Como a filosofia' 9 Helder Coelho tirou um curso de engenharia em que os três primeiros anos eram- critas - a bases de dados de bibliote- cas, permitindo saber, por exemplo, se um livro estava disponível

Instituto de Sistemas e Robotica

47

Efficacy and Safety of Praziquantel, Tribendimidine and Mebendazole in Patients with Co-infection of Clonorchis sinensis and Other Helminths  

PubMed Central

Background Both tribendimidine and mebendazole are broad-spectrum drugs for anti-intestinal nematodes. We aim to assess the efficacy and safety of tribendimidine and mebendazole in patients with co-infection of Clonorchis sinensis and other helminths. Method We performed a randomized open-label trial in Qiyang, People's Republic of China. Eligible participants were randomly assigned to one of four groups: (i) a single dose of 400 mg tribendimidine, (ii) 200 mg tribendimidine twice daily, (iii) 75 mg/kg praziquantel divided in four doses within 2 days, and (iv) a single dose of 400 mg mebendazole. Cure rates and egg reduction rates were assessed, and adverse events were monitored after treatments. Uncured patients accepted the second treatment with the same drugs after the first treatment. Results 156 patients were eligible for the study. Results from the first treatment showed that the cure rates of single-dose tribendimidine and praziquantel against C. sinensis were 50% and 56.8%, respectively; the single-dose tribendimidine achieved the cure rate of 77.8% in the treatment for hookworm, which was significantly higher than that of praziquantel; Low cure rates were obtained in the treatment of single-dose tribendimidine against Ascaris lumbricoides and Trichuris trichiura (28.6% and 23.1%). Results of the second treatment illustrated the cure rates of tribendimidine and praziquantel against C. sinensis were 78.1% and 75%, respectively. Most adverse events were mild and transient. Adverse events caused by tribendimidine were significantly less than praziquantel. Conclusion Single-dose tribendimidine showed similar efficacy against C. sinensis as praziquantel with less adverse events, and achieved significantly higher cure rate in the treatment for hookworm than those of praziquantel and mebendazole. Low cure rates, which were still higher than other drugs, were obtained in the treatment of single-dose tribendimidine against Ascaris lumbricoides and Trichuris trichiura. Trial Registration Controlled-Trials.com ISRCTN55086560 PMID:25122121

Xu, Li-Li; Jiang, Bin; Duan, Ji-Hui; Zhuang, Shi-Feng; Liu, Yong-Chun; Zhu, Shi-Qiao; Zhang, Li-Ping; Zhang, Hao-Bing; Xiao, Shu-Hua; Zhou, Xiao-Nong

2014-01-01

48

Efficacy and safety of oral praziquantel against Dicrocoelium dendriticum in llamas.  

PubMed

Dicrocoelium dendriticum can cause severe pathological changes of the liver and bile system in camelids, and therapeutic options for treatment are limited. To address this problem, the efficacy of two different dose rates of praziquantel was investigated in llamas suffering from natural D. dendriticum infections. 53 llamas were examined under field conditions on two occasions: before and two weeks after treatment. At the beginning of the study, the animals were weighed, randomly allocated to one of the treatment groups (n=21 each) or the control group (n=11) and dosed orally using a praziquantel-containing paste (250 mg/ml) at a dose of either 25 mg (group 1) or 50 mg (group 2) per kg of body weight. Criteria for efficacy were faecal egg count reduction (FECR) and extensity effect. Animals treated with 25 mg/kg of body weight showed a FECR of 85%. Therapy with 50 mg/kg led to a FECR of 91%. Almost twice the number of animals of group 1 (33%) still shed eggs two weeks after treatment compared with group 2. The results of this study indicate that 50 mg/kg oral praziquantel is required for efficacious dosing and that this dose rate is safe in llamas and thus is recommended for the treatment of camelids naturally infected with D. dendriticum. PMID:23845305

Dadak, Agnes M; Wieser, Claudia; Joachim, Anja; Franz, Sonja

2013-10-18

49

Novel praziquantel treatment regime for controlling asian tapeworm infections in pond-reared fish  

USGS Publications Warehouse

The Asian tapeworm Bothriocephalus achelognathii is an intestinal fish parasite that is nonnative to but widespread throughout the southwestern United States. Praziquantel is an anthelminthic drug commonly used to treat fish for Asian tapeworm; however, it does not kill tapeworm eggs, so the water in ponds used for fish rearing must be exchanged after treatment. Our objective was to determine whether a system containing both an intermediate copepod host and a definitive fish host for Asian tapeworm could be treated without exchanging the water by using a follow-up treatment for any tapeworms that developed from eggs released before or during the first treatment. Here, we have described a new praziquantel treatment regimen to control Asian tapeworm infections in freshwater-reared fish. To evaluate the efficacy of this regimen, we stocked 50 red shiners Cyprinella lutrensis and an intermediate copepod host, Cyclops vernalis, into each of six pond mesocosms containing artificial macrophytes, sand, and gravel to simulate natural pools and provide suitable substrate for the copepod's life history. The test fish population had been naturally infected with B. achelognathii and had an initial infection prevalence of 14% and an infection intensity of 2.14 ± 2.19 (mean ± SD) worms per fish. Three mesocosms were treated twice, each with 2.5 mg/L praziquantel; 19 d passed between treatments to allow for possible reinfection to occur. After a 2.5-month posttreatment period to allow any remaining tapeworms to reestablish themselves, we killed and dissected all of the remaining fish. No worms were found in treated fish; however, the control group had an infection prevalence of 18 ± 6% and an infection intensity of 3.45 ± 2.1 worms per fish. Based on these results, we concluded that the praziquantel treatment regime administered was efficacious and suggest testing it on a larger scale. We caution that praziquantel has not been approved by the U.S. Food and Drug Administration for use on fish but can be used legally in some situations.

Iles, Alison C.; Archdeacon, Thomas P.; Bonar, Scott A.

2012-01-01

50

Fraudes corporativas : uma análise das variáveis contábeis indicativas em empresas não financeiras de capital aberto no Brasil.  

E-print Network

??Trabalhos científicos com ferramental estatístico em contabilidade, utilizando variáveis contábeis indicativas, deram seus primeiros passos no estudo das fraudes corporativas no exterior no início da… (more)

Renato Ros

2011-01-01

51

Field efficacy of praziquantel oral paste against naturally acquired equine cestodes in Ethiopia.  

PubMed

The efficacy of an oral formulation of praziquantel (Equitape, Horse paste, Fort Dodge) in the reduction of cestode egg counts and serum antibody level against Anoplocephala perfoliata was assessed in 44 donkeys under field conditions. The donkeys were confirmed both by faecal examination and serum antibody assessed by an enzyme-linked immunosorbent assay to have natural infection with tapeworms. The donkeys were randomly allocated into treatment (n?=?22) and control (n?=?22) groups. The treatment group was treated with both praziquantel and ivermectin (Ivomec, Merial) at a dose rate of 1 mg/kg and 200 ?g/kg, respectively while the control group was treated only with ivermectin. Faecal samples were collected before treatment (day-0) and 2, 6, 8, 12, and 16 weeks post-treatment while blood samples were collected before treatment and 8 and 16 weeks after treatment and analysed. The results of the study demonstrated that praziquantel paste was highly effective in reducing cestode eggs in donkeys and had an efficacy of more than 99 % until week 16 (day?112). No cestode egg reappearance by 16 weeks post-treatment in any animal in the treatment group was observed while donkeys in the control group continued shedding cestode eggs. The immunological assay also showed a significant reduction in serum antibody level against A. perfoliata in treated donkeys compared to the control group (p?=?0.0001). This marked decrease in serum antibody level indicates reduced risk of cestode-associated colic and other gastrointestinal disorders and clinical diseases. No adverse reactions or clinical effects were encountered in any animal within either group throughout the trial period. PMID:23001508

Getachew, A M; Innocent, G; Proudman, C J; Trawford, A; Feseha, G; Reid, S W J; Faith, B; Love, S

2013-01-01

52

Clinical trials of efficacy of praziquantel horse paste 9% against tapeworms and its safety in horses.  

PubMed

The aim of this study with horses and a few ponies naturally infected with tapeworms was to confirm in clinical trials the efficacy and safety of a praziquantel horse paste 9%. The field trials were conducted in 1997 and 1998 in Canada, France, Germany and New Zealand. A secondary aim of the study in Canada was to determine if a 24h post-treatment fecal sample provides the best estimate of the prevalence of tapeworms in horses when using a fecal examination technique. Fecal samples were taken from each of 1062 animals at least three times pre-treatment (PRT). In Canada, fecal samples were examined using the Cornell-Wisconsin centrifugal flotation technique, and in France, Germany and New Zealand using a centrifugation/flotation technique. In each trial, the animals were randomized into two treatment groups: praziquantel horse paste 9% at 1mg/kg body weight (BW) and untreated. Fecal samples were taken from each animal nine times post-treatment and over a period of 5 weeks. In Canada, a fecal sample was taken also at 24h after treatment. Personnel examining the samples were "blinded" to treatment groups. On the day of treatment, each treated animal was examined for adverse reactions to the paste 10min after treatment and then hourly for 4h. Thereafter, each animal was examined once daily for 5 weeks. In Canada, Germany and New Zealand, the only tapeworm egg found was Anoplocephala perfoliata. In France, A. perfoliata was the most common species and a few animals had A. magna and Paranoplocephala mamillana. The prevalence of A. perfoliata among animals sampled in Canada, France, Germany and New Zealand was 51.8, 34.4, 13.1 and 26.2%, respectively. A total of 248 animals were treated with the praziquantel paste and all except one accepted it readily. There were 292 animals completing the study, 219 treated and 73 untreated. In Canada, Germany and New Zealand, the efficacy of the praziquantel horse paste 9% against A. perfoliata was 100%. In France, the efficacy against A. perfoliata, A. magna and P. mamillana was 90.9, 100 and 100%, respectively. The best estimate of prevalence for A. perfoliata in a herd was derived from fecal samples taken 24h after treatment. At 24h, 22 of 23 treated horses were positive, whereas on any day pre-treatment fewer horses were positive. Adverse reactions observed were mild to moderate colic and in only two treated horses. PMID:17101225

Slocombe, J Owen D; Heine, Josef; Barutzki, Dieter; Slacek, Brigitte

2007-03-31

53

Leucocyte Variation, an Insight of Host Defenses During Hymenolepiasis and Restoration with Praziquantel  

PubMed Central

Haematological studies in helminthiasis reveal drastic alterations in the white blood cells (leucocytes), and its various components like neutrophils, lymphocytes, monocytes and eosinophils. The use of proper anthelmintic agent, restores normalcy in the infected host. These variations during helminth infections reflect the host defense status in combating the parasitic attack. The present study involves the evaluation of these total and differential haematological alterations, induced in the laboratory mouse Mus musculus, infested with the intestinal helminth, Hymenolepis nana (dwarf tapeworm), and treated with the praziquantel, using an automatic Coulter Counter. PMID:22131626

Parvathi, J.; Karemungikar, Aruna

2011-01-01

54

Leucocyte variation, an insight of host defenses during hymenolepiasis and restoration with praziquantel.  

PubMed

Haematological studies in helminthiasis reveal drastic alterations in the white blood cells (leucocytes), and its various components like neutrophils, lymphocytes, monocytes and eosinophils. The use of proper anthelmintic agent, restores normalcy in the infected host. These variations during helminth infections reflect the host defense status in combating the parasitic attack. The present study involves the evaluation of these total and differential haematological alterations, induced in the laboratory mouse Mus musculus, infested with the intestinal helminth, Hymenolepis nana (dwarf tapeworm), and treated with the praziquantel, using an automatic Coulter Counter. PMID:22131626

Parvathi, J; Karemungikar, Aruna

2011-01-01

55

Schistosoma mansoni: Lack of correlation between praziquantel-induced intra-worm calcium influx and parasite death  

Microsoft Academic Search

The schistosomicidal activity of praziquantel (PZQ) is accompanied by a large influx of calcium into the worms, suggesting that this phenomenon could be the source of the observed muscular contraction, surface disruption and eventual death of the parasite. We have incubated live adult schistosomes in a medium containing radioactive calcium and we were able to confirm that PZQ does indeed

Livia Pica-Mattoccia; Tiziana Orsini; Annalisa Basso; Alfredo Festucci; Piero Liberti; Alessandra Guidi; Ana-Luiza Marcatto-Maggi; Sonia Nobre-Santana; Anna-Rita Troiani; Donato Cioli; Cristiana Valle

2008-01-01

56

Sequence and level of endogenous expression of calcium channel ? subunits in Schistosoma mansoni displaying different susceptibilities to praziquantel  

Microsoft Academic Search

Kohn et al. [J. Biol. Chem. 276 (2001) 36873] demonstrated that cells expressing the structurally unusual schistosome ? subunit SmCav?1 in their voltage-operated calcium channels, exhibit an increased current amplitude in the presence of praziquantel (PZQ). This suggests that the beta subunit is involved in PZQ activity and is consistent with the known pharmacological effects of the drug. If this

Cristiana Valle; Anna Rita Troiani; Alfredo Festucci; Livia Pica-Mattoccia; Piero Liberti; Adrian Wolstenholme; Katherine Francklow; Michael J Doenhoff; Donato Cioli

2003-01-01

57

[Efficacity of praziquantel in school-aged children in a hyperendemic zone for Schistoma haematobium (Niger, 1999)].  

PubMed

Urinary schistosomiasis is endemic in the Niger river valley. The aim of the present study was to assess the efficacy and side effects of a single oral dose of praziquantel at 40 mg/kg in the treatment of schistosomiasis. The investigation took place between April 5, 1999 and May 25, 1999. A total of 318 primary school children, aged from 6 to 16 years, of a Schistosoma haematobium endemic area were included in the survey. They underwent a macroscopic and parasitological examinations of the urine before treatment and two and six weeks after treatment. Treatment with praziquantel was given at 40 mg/kg of body weight in a single dose. Side effects due to praziquantel were assessed within the first 4 hours, and 24 hours after. Side effects were frequent (53.7%), especially occurring in the first four hours. Their expression was not associated with the sex of the child nor the intensity of the infestation. We noted that elder children expressed more complaints. The most frequent symptoms were abdominal pains, headaches and pruritus. All these signs were without gravity and resolved within the first twenty-four hours. Before treatment, the prevalence of infestation was 98%. Six weeks after treatment, 32% of children remained positive despite a marked reduction of egg excretion. In this survey, the side effects of the treatment were very frequent but without gravity. Using praziquantel, 68% of the subjects were cured completely. Urinary schistosomiasis control programs can continue to use it for mass treatment without risk. PMID:11346982

Garba, A; Tohon, Z; Sidiki, A; Chippaux, J P; de Chabalier, F

2001-03-01

58

Cytokine Pattern of T Lymphocytes in Acute Schistosomiasis mansoni Patients following Treated Praziquantel Therapy  

PubMed Central

Acute schistosomiasis is associated with a primary exposure and is more commonly seen in nonimmune individuals traveling through endemic regions. In this study, we have focused on the cytokine profile of T lymphocytes evaluated in circulating leukocytes of acute Schistosomiasis mansoni-infected patients (ACT group) before and after praziquantel treatment (ACT-TR group). Our data demonstrated increased values of total leukocytes, eosinophils, and monocytes in both groups. Interestingly, we have observed that patients treated with praziquantel showed increased values of lymphocytes as compared with noninfected group (NI) or ACT groups. Furthermore, a decrease of neutrophils in ACT-TR was observed when compared to ACT group. Analyses of short-term in vitro whole blood stimulation demonstrated that, regardless of the presence of soluble Schistosoma mansoni eggs antigen (SEA), increased synthesis of IFN-? and IL-4 by T-cells was observed in the ACT group. Analyses of cytokine profile in CD8 T cells demonstrated higher percentage of IFN-? and IL-4 cells in both ACT and ACT-TR groups apart from increased percentage of IL-10 cells only in the ACT group. This study is the first one to point out the relevance of CD8 T lymphocytes in the immune response induced during the acute phase of schistosomiasis. PMID:23401741

Silveira-Lemos, Denise; Fernandes Costa-Silva, Matheus; Cardoso de Oliveira Silveira, Amanda; Azevedo Batista, Mauricio; Alves Oliveira-Fraga, Lúcia; Soares Silveira, Alda Maria; Barbosa Alvarez, Maria Carolina; Martins-Filho, Olindo Assis; Gazzinelli, Giovanni; Corrêa-Oliveira, Rodrigo; Teixeira-Carvalho, Andréa

2013-01-01

59

Dynamics of Schistosoma haematobium egg output and associated infection parameters following treatment with praziquantel in school-aged children  

PubMed Central

Background Praziquantel is the drug of choice in preventive chemotherapy targeting schistosomiasis. Increasing large-scale administration of praziquantel requires monitoring of drug efficacy to detect early signs of development of resistance. Standard protocols for drug efficacy monitoring are necessary. Here, we determined the optimal time point for praziquantel efficacy assessment against Schistosoma haematobium and studied the dynamics of infection parameters following treatment. Methods Ninety school-aged children from south Côte d’Ivoire with a parasitologically confirmed S. haematobium infection were treated with a single oral dose of praziquantel (40?mg/kg) and followed up for 62?days post-treatment. Urine samples were collected on 23 schooldays during this period and were subjected to visual examination (macrohaematuria), urine filtration and microscopy (S. haematobium eggs) and reagent strip testing (microhaematuria, proteinuria and leukocyturia). Results Observed cure and egg reduction rates were highly dependent on the time point post-treatment. Egg reduction rates were high (>97%) in weeks 3–9 post-treatment. Cure rates were highest in weeks 6 (92.9%) and 9 (95.0%) post-treatment. The prevalence of infection-associated parameters decreased after treatment, reaching a minimum of 2.4% in weeks 5 (proteinuria) and 7 (leukocyturia) post-treatment, and 16.3% at the end of week 8 (microhaematuria). Macrohaematuria disappeared between weeks 3 and 6 post-treatment. Conclusions For monitoring praziquantel efficacy against S. haematobium, we recommend that the cure rate is assessed at week 6 post-treatment. The egg reduction rate can be evaluated earlier, from day 14 post-treatment onwards. Reagent strips are a useful additional tool for evaluating treatment outcomes in areas with high endemicity, preferably at weeks 5 and 6 post-treatment. The delayed decrease of microhaematuria confirms that lesions in the urinary tract persist longer than egg excretion post-treatment. PMID:23259435

2012-01-01

60

Efficacy of Milbemax (milbemycin oxime + praziquantel) in the treatment of dogs experimentally infected with Crenosoma vulpis.  

PubMed

Crenosoma vulpis, the fox lungworm, infects wild and domestic canids and is a cause of chronic respiratory disease in dogs in North America and Europe. The objective of this study was to determine the efficacy of milbemycin oxime (0.5mg/kg)/praziquantel (5mg/kg) (Milbemax; Novartis Animal Health, Inc.) against C. vulpis infection in a randomized, blinded, placebo-controlled study using experimentally infected dogs. Sixteen beagles (8 males, 8 females) were each given 100 infective third-stage larvae of C. vulpis. Fecal samples were examined for first-stage larvae by quantitative Baermann examination pre-exposure and at days 21, 28, 35, 42 and 49 post-infection (PI). All of the dogs were shedding larvae in the feces at 21 days PI. The dogs were randomly assigned to one of two groups. At 28 days PI, Group 1 (4 males, 4 females) received placebo only while Group 2 (4 males, 4 females) received a single treatment of milbemycin oxime (0.5mg/kg) and praziquantel (5mg/kg). The 16 dogs were euthanized and necropsied at 49 days PI. Lungs were removed, assessed for gross lesions (graded on a subjective scale 0-3 with 0 being normal) and C. vulpis were collected by lung-flush and counted. Samples of lung tissue were preserved for evaluation of histopathology and the lesions graded on a subjective scale (0-3 with 0 being normal). Gross and histopathology lesions were detected in all 8 untreated Group 1 dogs with mean subjective lesion scores of 1.8 ± 0.7 (range 1-3) and 3.0 ± 0.0 (range 3), respectively. Gross lesions were observed in 3/8 and histopathology lesions in all 8 of the treated Group 2 dogs with mean subjective lesion scores of 0.4 ± 0.5 (range 0-1) and 1.3 ± 0.4 (range 1-2), respectively. The mean (geometric) number for adult C. vulpis recovered in untreated dogs was 48.3 (range 25-70) compared with 0.65 (range 0-2) in animals treated with Milbemax. The resulting efficacy against C. vulpis was 98.7%. The number of C. vulpis was significantly lower for treated dogs than the burden in the untreated group (p=0.0002). A single dose of Milbemax (milbemycin oxime 0.5mg/kg+praziquantel 5mg/kg) was highly effective for the treatment of patent C. vulpis infection in dogs. A dosing interval for the prevention of clinical disease in dogs exposed to natural infections has not been established. PMID:24144516

Conboy, G; Bourque, A; Miller, L; Seewald, W; Schenker, R

2013-12-01

61

Artemether, artesunate, praziquantel and tribendimidine administered singly at different dosages against Clonorchis sinensis: A comparative in vivo study  

Microsoft Academic Search

We comparatively assessed the in vivo efficacy of artemether, artesunate, praziquantel and tribendimidine against different stages of Clonorchis sinensis. Rats were infected with 40–50 C. sinensis metacercariae, and drugs were administered singly by the oral route at different dosages. Rats were dissected 2–4 weeks post-treatment and C. sinensis trematodes were removed from the liver and bile ducts and counted. We

Shu-Hua Xiao; Xue Jian; Marcel Tanner; Zhang Yong-Nian; Jennifer Keiser; Jürg Utzinger; Qiang Hui-Qiang

2008-01-01

62

Safety and efficacy of praziquantel syrup (Epiquantel®) against Schistosoma haematobium and Schistosoma mansoni in preschool-aged children in Niger.  

PubMed

Given the characteristic age-prevalence curve of Schistosoma infection, preventive chemotherapy with praziquantel is primarily targeted at school-aged children, whilst, in highly endemic areas, other high-risk groups might be included for regular treatment. Nevertheless, schistosomiasis can affect children well before they reach school-age, but this population group is usually excluded from preventive chemotherapy. We assessed the safety and efficacy of praziquantel syrup (Epiquantel®) in preschool-aged children in three villages of Niger. Children aged ?72 months provided multiple urine and stool samples that were microscopically examined using standard protocols. Schistosoma-positive children were treated with praziquantel syrup at a dose of 40 mg/kg after a meal of millet porridge. Children remained under medical supervision for 4h and adverse events were recorded. Additionally, a questionnaire was administrated to the mothers/guardians 24h post-treatment for further probing of adverse events. Treatment efficacy was evaluated 3 and 6 weeks post-treatment using multiple stool and urine samples. A third of the 243 treated children reported adverse events within 4h, whilst a further 6.2% reported adverse events upon probing 24h post-treatment. Abdominal pain, bloody diarrhoea and sleepiness were the most common adverse events, but these were transient and self-limiting. Praziquantel syrup showed moderate-to-high efficacy against Schistosoma haematobium with egg reduction rates of 69.4% and 71.2% 3 and 6 weeks post-treatment and cure rates of 85.7% (95% confidence interval (CI) 79.7-90.5%) and 94.9% (95% CI 90.5-97.6%), respectively. Considerably lower cure and egg reduction rates were observed against Schistosoma mansoni (e.g. cure rate at 6-week post-treatment follow-up was only 50.6% (95% CI 39.9-61.2%). Concluding, praziquantel syrup is well tolerated in preschool-aged children with moderate-to-high efficacy against S. haematobium, but considerably lower efficacy against S. mansoni in Niger. A larger study is warranted to investigate the observed differences in species-specific susceptibilities and to assess operational issues and community-effectiveness. PMID:23237719

Garba, Amadou; Lamine, Mariama S; Djibo, Ali; Tahirou, Almoustapha; Aouami, Mahamadou Aboubacar; Alfari, Aichatou; Phillips, Anna E; Fenwick, Alan; Utzinger, Jürg

2013-11-01

63

A combination of praziquantel and the traditional medicinal plant Thunbergia laurifolia on Opisthorchis viverrini infection and cholangiocarcinoma in a hamster model.  

PubMed

Cholangiocarcinoma (CCA) associated by Opisthorchis viverrini remains a health problem in Southeast Asia including Thailand. At present, there is still no efficient treatment for CCA. Thunbergia laurifolia is a traditionally used medicinal plant; its aqueous leave extract possesses the antioxidant activity and anti-inflammatory on hamster opisthorchiasis had been reported previously. Here, we demonstrate the combined effects of the T. laurifolia extract plus antihelminthic drug, praziquantel (PZ) on hamsters with opisthorchiasis and hamsters with opisthorchiasis related-cholangiocarcinoma through light microscopic observations of histopathological changes, as well as liver function tests for alanine transaminase (ALT) and alkaline phosphatase, and kidney function tests for blood urea nitrogen and creatinine. Results showed T. laurifolia extract combined with praziquantel reduced inflammatory cell aggregation and inhibiting CCA development, which were correlated to the serum ALT level. These present studies suggest that administration of T. laurifolia after praziquantel treatment clearly improve the hepatobiliary system and could reduce the risk of subsequent CCA development in human. PMID:24057695

Wonkchalee, Nadchanan; Boonmars, Thidarut; Laummaunwai, Porntip; Aromdee, Chantana; Hahnvajanawong, Chariya; Wu, Zhiliang; Sriraj, Pranee; Aukkanimart, Ratchadawan; Chamgramol, Yaovaluk; Pairojkul, Chawalit; Juasook, Amornrat; Sudsarn, Pakkayanee

2013-12-01

64

Preliminary evidence of transcriptional immunomodulation by praziquantel in bluefin tuna and Atlantic salmon in vitro cultures.  

PubMed

Praziquantel (PZQ), long-used in veterinary and human medicine for the treatment of helminth parasites, is known to enhance humoral and cellular immune responsiveness in mammals but has unknown direct immunomodulatory capabilities in fish. In the present study, we examined the ability of PZQ to induce gene transcriptional changes in immune-competent primary tissue/organ cultures of two highly important yet evolutionarily discrete fish species--Southern bluefin tuna Thunnus maccoyii and Atlantic salmon Salmo salar. These cultures consisted of mixed blood cell population for both species, as well as intestinal explants from bluefin. Although expression profiles varied between species and tissue/organ type, PZQ induced both T-cell receptor (more than twofold) and IL-8 transcriptional expression (more than fourfold). Additionally, increased expression of other inflammatory cytokines including IL-1? was detected in blood cell cultures from both species, and a general pattern of heightened antiviral signaling was observed. Specifically, elevated transcription of Type I (IFN?) and Type II (IFN?) interferon in Atlantic salmon blood cultures along with elevated expression of MHC class I in blood cultures of both species. These findings provide preliminary evidence for direct immunomodulation by PZQ in fish and insight into its potential capacity as an immune stimulant/adjuvant in the rapidly expanding aquaculture industry. PMID:24632044

Polinski, Mark; Bridle, Andrew; Neumann, Lukas; Nowak, Barbara

2014-05-01

65

[Coverage rate and satisfaction of populations after mass treatment with praziquantel and albendazole in Mali].  

PubMed

In Mali, schistosomiasis always remains a major public health problem. In 2005, mass treatment campaigns with praziquantel and albendazole have been organized in all endemic regions. The present study aimed to assess the impact of these mass treatment campaigns and the recipient's satisfaction in two endemic areas (Mopti and Ségou). It was a cross-sectional study with one passage from February to March 2006. The study carried out on political authorities (n=142), teachers and school administers (n=70), health workers (n=46), community distributors (n=33), community members (n=2170) and pupils (n=2480). We used Lot Quality Assurance Sample (LQAS) to determine treatment coverage and recipient's satisfaction. Two types of lots were considered, villages and schools. Questionnaires were used for investigation. In Ségou, the treatment rates varied from 100% at school level and in community in Bla district to 97.2% in the community of Ségou town. In Mopti, a treatment rate of 100% was observed in Bankass and Douentza both at school and in the community. The proportion of happiest individuals (to feel well) after the mass treatment campaign was 72.3% among pupils and 76.6% in the community. The results of this study suggest that the high treatment coverage rates observed during these campaigns should be sustained by a yearly chemotherapy strategy preceded by a community's health education programmes. PMID:19666362

Sangho, H; Dabo, A; Sidibé, A; Dembélé, R; Diawara, A; Diallo, A; Konaté, S

2009-01-01

66

An Artemisinin Derivative of Praziquantel as an Orally Active Antischistosomal Agent  

PubMed Central

Background Schistosomiasis is a major health problem in tropical and sub-tropical areas caused by species of trematode belonging to the genus Schistosoma. The treatment and control of this disease has been relying on the use of a single drug praziquantel. However, the drug resistance concern urged the development of new drugs against schistosoma. Here, we report our systematic biological evaluation of DW-3-15, a new lead compound developed based on our conjugation design rationale as an effective anti-schistosomal agent. Methodology/Principal Findings The antischistosomal activity of DW-3-15 was systematically evaluated in S. japonicum infected mouse model for its stage-sensitivity and dose response. The results revealed that DW-3-15 exhibited 60–85% worm reduction rate against different development stage of worm. Scanning electron microscopy (SEM) observation indicated that DW-3-15 may damage to the tegument of male schistosomes. Conclusions/Significance Our results demonstrated that DW-3-15 showed potent anti-schistosomal activities in vivo. The results strongly support our conjugation design strategy of artemisinin analogs and further development of DW-3-15 as a new lead compound as anti-schistosomal agent. PMID:25386745

Chen, Jinglei; Sun, Huan; Qiao, Chunhua; Xia, Chao-ming

2014-01-01

67

Eurytrema pancreaticum: the in vitro effect of praziquantel and triclabendazole on the adult fluke.  

PubMed

The efficacy and tolerance of the 80 microg/ml praziquantel (PZQ) and 40 microg/ml triclabendazole (TCZ) against adult stage Eurytrema pancreaticum in vitro were investigated at 3, 12, and 15 h incubation. Motility of the flukes and histopathological changes were studied. Sudden paralysis and death were observed after exposed to PZQ as early as 3h incubation. In contrast, the TCZ treated flukes showed active mobility at all intervals. By light microscopic examination, severe damages in various organs such as tegument, muscle, and testes were observed early at 12h incubation of these drugs. PZQ caused more severe damage to flukes than TCZ. There were vigorous contraction of musculature, progressive shrinkage of circular and longitudinal muscles, vacuolization and disintegration of the tegument disrupting the worms' outer surface including detachment of spines in the PZQ treatment. The cells in testes were slightly increased in size and followed by degeneration leaving several hollow spaces. The uterus and vitelline glands remained unaffected. The direct observation of the fluke motility and light microscopic study highly suggested that PZQ was more effective than TCZ treatment for the eurytremiasis infection. PMID:16125702

Jiraungkoorskul, Wannee; Sahaphong, Somphong; Tansatit, Tawewan; Kangwanrangsan, Niwat; Pipatshukiat, Siriporn

2005-11-01

68

Reinfection of Dogs with Fish-Borne Zoonotic Trematodes in Northern Vietnam following a Single Treatment with Praziquantel  

PubMed Central

Background Fish-borne zoonotic trematodes (FZT) infections including liver- and minute intestinal flukes are common in Southeast Asia in both humans and domestic animals eating raw fish and since 2010, the liver flukes are recognised as neglected tropical diseases by WHO. Mass drug treatment with praziquantel is advised for humans, but no recommendations for control of the FZT in the reservoir hosts exist. Methodology/Principal Findings A study was conducted to assess the ability of praziquantel treatment for control of FZT in farm dogs in an endemic area in Northern Vietnam. Initially, 101 dogs from 73 households were examined for small trematode eggs in their faeces. Forty seven copro-positive dogs were included in the study. Thirty eight dogs received treatment with a single dose of 40 mg/kg of praziquantel. A group of nine dogs were left untreated. Coprological examination for small trematode eggs was performed on day 0, 3, 10, 30, 60, 90 and 120 post treatment. Farmers were questioned about dog keeping practises. All dogs were copro-negative for small trematode eggs on both day 3 and 10 post treatment. From day 30 onwards previously negative dogs became positive again. The reinfection rates were 26.3% (day 30), 45.5% (day 60), 53.1% (day 90), 61.3% (day 120).The nine untreated dogs remained positive throughout the study period. There was no difference in the intensity of infection at day 0 and 120 neither in the treated or untreated group. Conclusion Dogs had easy access to raw fish and did not receive treatment against flukes by their owner. More than 50% of the dogs were reinfected 3 months post treatment. We do not recommend controlling FZT infections in dogs by anthelmintic treatment alone since reinfection occurs fast under the existing farm management systems. PMID:24392175

Nissen, Sofie; Nguyen, Lan Anh Thi; Thamsborg, Stig Milan; Dalsgaard, Anders; Johansen, Maria Vang

2014-01-01

69

Phase III clinical trials with praziquantel in S. japonicum infections in the Philippines.  

PubMed

Following successful Phase II clinical studies with praziquantel (2-cyclohexylcarbonyl-1,2,3,6,7,11b-hexahydro-4H-pyrazino [2,1-a]isoquinolin-4-one, EMBAY 8440, Biltricide), expanded field trials of Phase III were conducted in Mindoro Oriental, Leyte and Davao Norte, to reassess efficacy, safety and acceptability of the drug on a larger scale. A total of 6,134 cases were treated with the best tolerated and effective dose of 60 mg/kg bwt which for practical purposes was given in 2 instead of 3 divided doses as applied in the earlier trials. Two aliquots of one stool from each individual were examined quantitatively by a modification of the thick smear method one week before, six and twelve months after treatment. Although 67.8% were noted to have drug-related side effects, most were mild to moderate, with only 1.2% considered as severe. Severe reactions consisted mainly of colicky abdominal pain, occurring about 1 h after drug intake, usually accompanied by fever, sweating, urge to defecate, and occasionally by discharge of bloody stool. These reactions, however, required only symptomatic treatment with antispasmodics and antipyretics. Stool follow-up 6 months after treatment showed 89.2% of EPG (eggs per gram of faeces) negativity, with an overall egg reduction of 91.1%. Twelve months after treatment, practically the same results were obtained with 87.5% still negative cases and an egg reduction of 90.5%. This study confirms safety and efficacy of the drug as well as its acceptability when given on a community wide scale. PMID:6391506

Santos, A T; Blas, B L; Portillo, G; Noseñas, J S; Poliquit, O; Papasin, M

1984-01-01

70

Impact of drug dosage and brand on bioavailability and efficacy of praziquantel.  

PubMed

The efficacy of two brands (brand 1 = Biltricide; Bayer AG, Leverkusen, Germany; brand 2 = Distocide; EPICO pharmaceuticals, Cairo, Egypt) of praziquantel (PZQ) in full and half doses (40 and 20 mg kg-1) monitored as percentage egg reduction and cure rate was investigated in S. mansoni infected school-children. A total of 506 school-children (8-16 years of age) were classified into three groups according to their intensity of infection, heavy [> 500 eggs per grams (epg)], moderate (100-500 epg) and light (< 100 epg), after examination three stool samples (three slides per sample) on three consecutive days. Percentage egg reduction and cure rate were monitored 4 and 10 weeks post-treatment for each dose regimen in the different test groups. Before testing the efficacy of either bran in patients, the pharmacokinetic parameters of the two brands were studied in non-infected normal volunteers. Statistical analysis of the pharmacokinetic parameters of brand 1 vs brand 2 (in a dose of 20 or 40 mg kg-1) revealed no significant difference in elimination (ke), absorption rate constant (ka), elimination half life (t1/2e), area under the time-concentration curve (Auc), serum maximum concentration (Cpmax) and time to maximum concentration (Tmax). As regards the efficacy of test drugs, statistical analysis revealed that up to 10 weeks post-treatment the two brands of PZQ in full dose were equally effective in reducing egg count as their half doses except in heavily infected cases treated with brand 2 of PZQ.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:7784306

Metwally, A; Bennett, J; Botros, S; Ebeid, F; el attar, G el D

1995-01-01

71

Inhibition or Knockdown of ABC Transporters Enhances Susceptibility of Adult and Juvenile Schistosomes to Praziquantel  

PubMed Central

Parasitic flatworms of the genus Schistosoma cause schistosomiasis, a neglected tropical disease that affects hundreds of millions. Treatment of schistosomiasis depends almost entirely on the drug praziquantel (PZQ). Though essential to treating and controlling schistosomiasis, a major limitation of PZQ is that it is not active against immature mammalian-stage schistosomes. Furthermore, there are reports of field isolates with heritable reductions in PZQ susceptibility, and researchers have selected for PZQ-resistant schistosomes in the laboratory. P-glycoprotein (Pgp; ABCB1) and other ATP binding cassette (ABC) transporters remove a wide variety of toxins and xenobiotics from cells, and have been implicated in multidrug resistance (MDR). Changes in ABC transporter structure or expression levels are also associated with reduced drug susceptibility in parasitic helminths, including schistosomes. Here, we show that the activity of PZQ against schistosome adults and juveniles ex vivo is potentiated by co-administration of either the highly potent Pgp inhibitor tariquidar or combinations of inhibitors targeting multiple ABC multidrug transporters. Adult worms exposed to sublethal PZQ concentrations remain active, but co-administration of ABC transporter inhibitors results in complete loss of motility and disruption of the tegument. Notably, juvenile schistosomes (3–4 weeks post infection), normally refractory to 2 µM PZQ, become paralyzed when transporter inhibitors are added in combination with the PZQ. Experiments using the fluorescent PZQ derivative (R)-PZQ-BODIPY are consistent with the transporter inhibitors increasing effective intraworm concentrations of PZQ. Adult worms in which expression of ABC transporters has been suppressed by RNA interference show increased responsiveness to PZQ and increased retention of (R)-PZQ-BODIPY consistent with an important role for these proteins in setting levels of PZQ susceptibility. These results indicate that parasite ABC multidrug transporters might serve as important targets for enhancing the action of PZQ. They also suggest a potentially novel and readily-available strategy for overcoming reduced PZQ susceptibility of schistosomes. PMID:25330312

Kasinathan, Ravi S.; Sharma, Lalit Kumar; Cunningham, Charles; Webb, Thomas R.; Greenberg, Robert M.

2014-01-01

72

The inability of tapeworm Hymenolepis diminuta and fluke Dicrocoelium dendriticum to metabolize praziquantel.  

PubMed

Biotransformation enzymes can, to a certain extent, protect parasitic worms against the toxic effects of anthelmintics and can contribute to drug-resistance development. The objective of our work was (1) to find and identify phase I and II metabolites of the anthelmintic praziquantel (PZQ) formed by the lancet fluke (Dicrocoelium dendriticum) and the rat tapeworm (Hymenolepis diminuta) and (2) to compare PZQ metabolites in helminths with PZQ biotransformation in rat as host species. Ultra high performance liquid chromatography/tandem mass spectrometry (UHPLC/MS/MS) was used for this purpose. During in vitro incubations, mitochondria-like and microsomes-like fractions (prepared from homogenates of adult worms or from rat liver homogenate) were incubated with 10 and 100 ?M PZQ. Liquid/liquid extraction was used for samples during in vitro experiments. In the ex vivo study, living D. dendriticum and H. diminuta adults were incubated in RPMI-1640 medium in the presence of 50 nM or 100 nM PZQ for 24h. After incubation, the worms were removed from the medium and homogenized. Homogenates of worms, medium from the incubation of worms or rat hepatocytes and rat urine (collected during 24h after oral PZQ administration) were separately extracted using solid-phase extraction. The results showed that both D. dendriticum and H. diminuta enzymatic systems are not able to metabolize PZQ. On the other hand, thirty one different phase I and four phase II PZQ metabolites were detected in rat samples using UHPLC/MS/MS analyses. These results show that our experimental helminths, as the members of tapeworm and fluke groups of parasites, are not able to deactivate PZQ, and that the biotransformation enzymes of the studied helminths do not contribute to PZQ-resistance. PMID:21996005

Vok?ál, Ivan; Jirásko, Robert; Jedli?ková, Veronika; Bártíková, Hana; Skálová, Lenka; Lamka, Ji?í; Hol?apek, Michal; Szotáková, Barbora

2012-04-30

73

A randomized, double-blind, placebo-controlled trial of safety and efficacy of combined praziquantel and artemether treatment for acute schistosomiasis japonica in China  

Microsoft Academic Search

Objective To evaluate the safety and efficacy of combining artemether (AM) and praziquantel (PZQ) in different regimens for treating acute schistosomiasis japonica. Methods We undertook a randomized, double-blind, placebo-controlled trial within four specialized schistosomiasis hospitals in the Dongting Lake region, Hunan province, China, between May 2003 and December 2005. Study participants were randomized into one of four treatment regimes: group

Xun-Ya Hou; Donald P McManus; Darren J Gray; Julie Balen; Xin-Song Luo; Magda Ellis; Gail M Williams; Yue-Sheng Li

74

Performance and Safety of Praziquantel for Treatment of Intestinal Schistosomiasis in Infants and Preschool Children  

PubMed Central

Background In 2012 the WHO formally recognised that infants and preschool children are at significant risk of schistosomiasis and qualify for treatment with praziquantel (PZQ). Targeted surveys determining both the performance and safety of this drug are now needed in endemic areas. We have formally assessed parasitological cure and putative side-effects in a prospective cohort of Schistosoma mansoni-infected children (aged 5 months–7 years old) in lakeshore settings of Uganda. Methodology/Principal Findings From a total of 369 children found to be egg-patent for intestinal schistosomiasis, 305 were followed-up three to four weeks after PZQ treatment and infection status re-assessed. Separately, a previously tested side-effect questionnaire was employed before and 24 hours after PZQ treatment to assess incidence and amelioration of symptoms in young children and their mothers. While the overall observed parasitological cure was 56.4%, a significant difference was found between a sub-set of children who had a history of multiple PZQ treatments (between one and four in an 18 month period), where cure rate was 41.7%, and those who had never received treatment (cure rate was 77·6%). PZQ proved to be safe, with only mild reported side effects which cleared within a month after treatment. Prevalence of reported symptoms was significantly lower in children than in mothers, and fewer side-effects were reported upon subsequent rounds of PZQ treatment. Conclusion/Significance Our findings show that PZQ treatment of young children resulted in satisfactory cure rates, and marked reduction in egg-output, with only mild and transient reported side-effects. However, the cure rate is clearly lower in younger children and those with history of previous treatment. Cure rate, but not egg reduction rate, was also lower in children with heavier pre-intervention infection intensity. With chemotherapy now recommended as a long-term strategy for disease control in young children, research into optimising the periodicity of targeted treatment strategies is now crucial. PMID:23094120

Sousa-Figueiredo, José C.; Betson, Martha; Atuhaire, Aaron; Arinaitwe, Moses; Navaratnam, Annalan M. D.; Kabatereine, Narcis B.; Bickle, Quentin; Stothard, J. Russell

2012-01-01

75

A Multicentre Randomized Controlled Trial of the Efficacy and Safety of Single-Dose Praziquantel at 40 mg\\/kg vs. 60 mg\\/kg for Treating Intestinal Schistosomiasis in the Philippines, Mauritania, Tanzania and Brazil  

Microsoft Academic Search

BackgroundPraziquantel at 40 mg\\/kg in a single dose is the WHO recommended treatment for all forms of schistosomiasis, but 60 mg\\/kg is also deployed nationally.Methodology\\/Principal FindingsFour trial sites in the Philippines, Mauritania, Tanzania and Brazil enrolled 856 patients using a common protocol, who were randomised to receive praziquantel 40 mg\\/kg (n = 428) or 60 mg\\/kg (n = 428). While

Piero L. Olliaro; Michel T. Vaillant; Vincente J. Belizario; Nicholas J. S. Lwambo; Mohamed Ouldabdallahi; Otavio S. Pieri; Maria L. Amarillo; Godfrey M. Kaatano; Mamadou Diaw; AnaLucia C. Domingues; Tereza C. Favre; Olivier Lapujade; Fabiana Alves; Lester Chitsulo

2011-01-01

76

Sensitivity and Specificity of Multiple Kato-Katz Thick Smears and a Circulating Cathodic Antigen Test for Schistosoma mansoni Diagnosis Pre- and Post-repeated-Praziquantel Treatment  

PubMed Central

Background Two Kato-Katz thick smears (Kato-Katzs) from a single stool are currently recommended for diagnosing Schistosoma mansoni infections to map areas for intervention. This ‘gold standard’ has low sensitivity at low infection intensities. The urine point-of-care circulating cathodic antigen test (POC-CCA) is potentially more sensitive but how accurately they detect S. mansoni after repeated praziquantel treatments, their suitability for measuring drug efficacy and their correlation with egg counts remain to be fully understood. We compared the accuracies of one to six Kato-Katzs and one POC-CCA for the diagnosis of S. mansoni in primary-school children who have received zero to ten praziquantel treatments. We determined the impact each diagnostic approach may have on monitoring and evaluation (M&E) and drug-efficacy findings. Method/Principle Findings In a high S. mansoni endemic area of Uganda, three days of consecutive stool samples were collected from primary school-aged children (six - 12 years) at five time-points in year one: baseline, one-week-post-, four-weeks-post-, six-months-post-, and six-months-one-week-post-praziquantel and three time-points in years two and three: pre-, one-week-post- and four-weeks-post-praziquantel-treatment/retreatment (n?=?1065). Two Kato-Katzs were performed on each stool. In parallel, one urine sample was collected and a single POC-CCA evaluated per child at each time-point in year one (n?=?367). At baseline, diagnosis by two Kato-Katzs (sensitivity?=?98.6%) or one POC-CCA (sensitivity?=?91.7%, specificity?=?75.0%) accurately predicted S. mansoni infections. However, one year later, a minimum of three Kato-Katzs, and two years later, five Kato-Katzs were required for accurate diagnosis (sensitivity >90%) and drug-efficacy evaluation. The POC-CCA was as sensitive as six Kato-Katzs four-weeks-post and six-months-post-treatment, if trace readings were classified as positive. Conclusions/Significance Six Kato-Katzs (two/stool from three stools) and/or one POC-CCA are required for M&E or drug-efficacy studies. Although unable to measure egg reduction rates, one POC-CCA appears to be more sensitive than six Kato-Katzs at four-weeks-post-praziquantel (drug efficacy) and six-months-post-praziquantel (M&E). PMID:25211217

Lamberton, Poppy H. L.; Kabatereine, Narcis B.; Oguttu, David W.; Fenwick, Alan; Webster, Joanne P.

2014-01-01

77

Percepções de estudantes de licenciatura em Ciências Naturais sobre uma unidade didática acerca da humanização das ciências com base nos estudos de Gregor Mendel sobre a hereditariedade.  

E-print Network

??Dissertação (mestrado)—Universidade de Brasília, Instituto de Ciências Biológicas, Instituto de Física, Instituto de Química, Faculdade UnB Planaltina, Programa de Pós-Graduação em Ensino de Ciências, Mestrado… (more)

Melo, Juliana Ricarda de

2014-01-01

78

Mutagenic and physiological responses in the juveniles of African catfish, Clarias gariepinus (Burchell 1822) following short term exposure to praziquantel.  

PubMed

Praziquantel (PZQ) is an acylated quinoline-pyrazine originally developed for veterinary application but now one of the most used anti-helminthic drugs for treatment of certain trematodes and cestodes in both human and other animals. The present study investigated the mutagenic and physiological responses in the juveniles of African catfish, Clarias gariepinus following short term exposure to praziquantel. Based on the 53.52 mg/l 96 h LC50 of PZQ obtained, two sublethal concentrations of 5.35 and 10.70 mg/l of the drug were selected and fish were exposed to these concentrations and control for 15 days. Micronuclei induction in the peripheral blood of PZQ-exposed fish was highest on day 10 but the fish morphological parameters were not affected. The packed cell volume (PCV) was significantly reduced (p<0.05) from day 5 while red blood cells (RBC) and hemoglobin (Hb) significantly declined (p<0.05) on day 15. Macrocytic anemia was observed on day 1 of study and thereafter microcytic anemia developed on day 5 of study. The white blood cell (WBC) was significantly (p<0.05) elevated from day 10 of exposure while values of mean cellular volume (MCV), mean cellular hemoglobin (MCH) and mean cellular hemoglobin concentration (MCHC) were not significantly different (p>0.05) from the control. Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and glucose levels significantly increased while protein reduced (p<0.05) throughout the exposure period but a mixed trend was observed in the leukocyte differentials. PZQ should be used with caution as sublethal exposure elicited micronucleus induction and alterations of hematological and biochemical parameters in the fish. PMID:24974067

Nwani, Christopher Dididgwu; Nnaji, Macniel Chijioke; Oluah, Stanley Ndubuisi; Echi, Paul Chinedu; Nwamba, Helen Ogochukwu; Ikwuagwu, Ogbonnaya Egbe; Ajima, Malachy Nwigwe Okechukwu

2014-08-01

79

Anlise de Desempenho da Utilizao do Framework AFME em uma Aplicao de Seguimento de Trajetria para Rede de Sensores sem Fio  

E-print Network

para Rede de Sensores sem Fio utilizando Agentes Móveis EDISON PIGNATON DE FREITAS, BERNHARD B�SCH Avanços na área de comunicação sem fio e rede de sensores permitiram um crescimento do uso de Rede de Sensores sem Fio. Este tipo de rede está sendo utilizada em diversas aplicações emergentes, o que justifica

Wagner, Flávio Rech

80

Five-year impact of repeated praziquantel treatment on subclinical morbidity due to Schistosoma japonicum in China.  

PubMed

We report the 5-year impact (1996-2001) of repeated praziquantel chemotherapy on subclinical morbidity related to Schistosoma japonicum infection. We repeated stool examinations and hepatosplenic ultrasonography in a cohort of 120 individuals living on an island with endemic infection in Dongting Lake, China. Prevalence of schistosome infection fell by 43% and intensity (geometric mean eggs per gram) declined by 80% over the 5 years. However, transmission persisted at a dangerously high rate of 13% per year for re-infection or new infection in the cohort. The prevalence of left-lobe enlargement and dilated portal vein fell significantly (P < 0.01) to about half initial levels although a few patients progressed during the study period. At study endpoint, infection was nearly twice as common if the portal vein was dilated (23% versus 13%, respectively), but this association was not statistically significant (P > 0.05). However, endpoint infection was even more strongly associated with left-lobe enlargement (57% versus 15%, P < 0.01). The proportions of subjects with improved parenchymal and periportal fibrosis were much higher than the proportions of subjects that progressed (P < 0.05). Reduction of prevalence and intensity of infection, and improvement of subclinical morbidity, were benefits of repeated treatments. Further research is needed to understand why some patients developed fibrosis despite substantial reductions in egg counts and to evaluate the functional importance of residual subclinical morbidity after chemotherapy-based control in the lake and marshland area of China. PMID:12497984

Li, Y S; Sleigh, A C; Li, Y; Tanner, M; Dessein, A; Williams, G M; McManus, D P

2002-01-01

81

Schistosoma japonicum calcium-binding tegumental protein SjTP22.4 immunization confers praziquantel schistosomulumicide and antifecundity effect in mice.  

PubMed

A family of platyhelminth tegument-specific proteins comprising of one or two calcium ion binding EF-hand and a dynein light chain-like domain, termed tegumental proteins, are considered as candidates of vaccine. In this study, we cloned and characterized SjTP22.4, a novel membrane-anchored tegumental protein in Schistosoma japonicum with theoretic MW of 22.4. The recombinant SjTP22.4 could be recognized by S. japonicum infected sera. Immunofluorescence revealed that this protein is not only located on the surface of tegument of adult and schistosomulum and cercaria, but also in the parenchymatous tissues and intestinal epithelium. Circular dichroism (CD) measurement demonstrated rSjTP22.4 had Ca(2+)-binding ability. The rSjTP22.4 vaccination without adjuvants produced comparable high level of antibody with that of immunization with adjuvants together indicated it was an antigen of strong antigenicity. The level of IgG1 is much higher than that of IgG2a and IgE is nearly negative in S. japonicum-infected and rSjTP22.4 immunized mice. In cercaria challenge experiment, mice vaccinated with SjTP22.4 showed no reduction in adult burden and egg production, comparing with the control mice, but 41% decrease in egg mature rate and 32% reduction in liver egg granuloma area. However, the SjTP22.4 immunized mice that received praziquantel treatment at 10d post infection caused 26% reduction in adult burden and 53% decrease in egg mature rate, comparing with the control mice only received praziquantel treatment. In conclusion, SjTP22.4 is a valuable vaccine candidate for S. japonicum of anti-pathogenesis and anti-transmission effect and plays a synergetic role in praziquantel to kill schistosomulum. PMID:22683520

Zhang, Zhaoping; Xu, Hongxu; Gan, Wenjia; Zeng, Suxiang; Hu, Xuchu

2012-07-20

82

Efficacy of a novel topical fipronil, (S)-methoprene, eprinomectin and praziquantel combination against naturally acquired intestinal nematode and cestode infections in cats.  

PubMed

The efficacy of a novel topical combination formulation of fipronil, (S)-methoprene, eprinomectin and praziquantel against naturally acquired intestinal nematode and cestode infections in cats was evaluated in seven negative control, blinded studies. Cats were selected based on a pre-treatment faecal examination indicating a patent infection with at least hookworms (two studies), Toxocara ascarids (one study), taeniid cestodes (two studies) or Dipylidium cestodes (two studies). In each study, cats were assigned randomly to blocks of two animals each, based on decreasing pre-treatment body weight and were randomly allocated to one of two groups of six to 12 cats: untreated (control) or treated with topical fipronil (8.3%, w/v), (S)-methoprene (10%, w/v), eprinomectin (0.4%, w/v) and praziquantel (8.3%, w/v) (BROADLINE(®), Merial) at 0.12 mL/kg body weight (providing a minimum of 10mg fipronil+12 mg S-methoprene+0.5mg eprinomectin+10mg praziquantel per kg body weight). The topical treatment was administered directly on the skin in the midline of the neck in a single spot once on Day 0. For parasite recovery and count, cats were euthanized humanely and necropsied seven or ten days after treatment. A single treatment with the novel topical combination product provided 91% efficacy against Ancylostoma braziliense, ? 99% efficacy against Ancylostoma tubaeforme, and >97% efficacy against Toxocara cati. Similarly, excellent efficacy was established against Taenia taeniaeformis, Dipylidium caninum and Diplopylidium spp. as demonstrated by >97% and up to 100% reductions of cestode counts in the treated cats when compared to the untreated controls (P<0.01). All cats accepted the treatment well based on health observations post-treatment and daily health observations. No adverse experiences or other health problems were observed throughout the studies. The results of this series of controlled studies demonstrated high efficacy and excellent acceptability of the novel topical combination formulation of fipronil, (S)-methoprene, eprinomectin and praziquantel against a broad range of feline intestinal nematode and cestode infections. PMID:24703071

Knaus, Martin; Abu-Madi, Marawan A; Ibarra-Velarde, Froylán; Kok, Dawie J; Kusi, Ilir; Postoli, Rezart; Chester, S Theodore; Rosentel, Joseph; Alva, Roberto; Irwin, Jennifer; Visser, Martin; Winter, Renate; Rehbein, Steffen

2014-04-28

83

Efficacy in cats of a novel topical combination of fipronil, (S)-methoprene, eprinomectin, praziquantel, against induced infestations of Echinococcus multilocularis.  

PubMed

Although foxes are the main reservoir of Echinococcus multilocularis, it is recognized that dogs and cats also may become infected. In cats the infection and egg production rates are usually low. Nevertheless, cats are a potential source of transmission of E. multilocularis. Due to the high human medical significance of E. multilocularis infection, it is important in endemic areas that owned cats are dewormed regularly. This paper presents the efficacy results of a new topical formulation, Broadline(®) (Merial) tested against E. multilocularis infection in cats. Two blinded laboratory studies were conducted to evaluate this novel topical combination of fipronil, (S)-methoprene, eprinomectin, and praziquantel against E. multilocularis. In each study, purpose-bred cats were assigned randomly to two treatment groups of 10 cats each: one untreated control group and one group treated at the minimum therapeutic dose of 0.12 mL/kg bodyweight to deliver 10mg fipronil, 12 mg (S)-methoprene, 0.5mg eprinomectin and 10mg praziquantel/kg bodyweight. The cats were inoculated orally with E. multilocularis protoscolices, 22 or 23 days before treatment. Based on necropsy and intestinal worm count, 8 or 11 days after treatment, the two studies confirmed 100% efficacy of Broadline(®) against adult E. multilocularis. PMID:24703072

Tielemans, Eric; Manavella, Coralie; Visser, Martin; Theodore Chester, S; Rosentel, Joseph

2014-04-28

84

UMA EXPERIÊNCIA COM O PROJETO MANHATTAN NO ENSINO FUNDAMENTAL An experience with the Manhattan Project in the Elementary School  

Microsoft Academic Search

Resumo: O presente artigo discute uma dissertação de mestrado que utilizou uma perspectiva educacio- nal voltada à formação de cidadãos e defendida na proposta de Edgar Morin e no relatório da UNESCO sobre educação para o século XXI. Para isso, aborda a importância de uma nova prática escolar, preocupa- da em manter o estudante como centro das atividades em sala

Rafaela Samagaia; Luiz O. Q. Peduzzi

85

OPTIMIZAC ~ AO EM REDES  

E-print Network

OPTIMIZAC¸ ~ AO EM REDES UMA VIS ~ AO GLOBAL Deolinda Dias Rasteiro, Jose Luis Santos, Marta Braz; Optimiza¸c~ao em Redes ­ Uma Vis~ao Global N = fv 1 ; : : : ; v n g j f1; : : : ; ng ­ conjunto de n'os (v est~ao associados parâ??ametros Exemplo: `j 'i 1 `j 'i 2 `j 'i 3 `j 'i 4 \\Gamma \\Gamma \\Gamma \\Gamma

Pascoal, Marta Margarida Braz

86

SOPHIA ANDRESEN: UMA POÉTICA DA FELICIDADE E DO DIA?  

Microsoft Academic Search

RESUMO: A comunicação aqui proposta aponta como linha de leitura da poesia de Sophia de Mello Breyner Andresen uma reflexão em torno da presença de ecos da lírica horaciana e da doutrina epicurista, seja como ponto declarado de divergência, de encontro e acordo, ou mesmo em intertextualidade com autores que trabalharam idéias e valores daquela doutrina, principalmente Pessoa - Reis.

Virgínia Bazzetti Boechat

87

Efficacy of a novel topical combination of fipronil, (S)-methoprene, eprinomectin and praziquantel against larval and adult stages of the cat lungworm, Aelurostrongylus abstrusus.  

PubMed

The efficacy of a novel topical combination of fipronil 8.3% w/v, (S)-methoprene 10% w/v, eprinomectin 0.4% w/v, and praziquantel 8.3% w/v (BROADLINE(®),(1) Merial) against larval and adult Aelurostrongylus abstrusus lungworms in cats was assessed in a controlled laboratory study. The study included 48 purpose-bred, short-haired cats which were each inoculated with 225 infective A. abstrusus larvae. The cats were formed into eight blocks based on pre-treatment bodyweight and were then, within each block, randomly allocated to one of six treatment groups: untreated control; treated once when A. abstrusus were expected to be third-stage larvae (4 days post inoculation [dpi]), fourth-stage larvae (7 dpi), immature adults (14 dpi) or adult nematodes (32 dpi), or treated twice, once when A. abstrusus were expected to be third-stage larval and once again when A. abstrusus were expected to be adult nematodes (4 dpi+32 dpi). Cats weighing ? 0.8-2.5 kg received one 0.3 mL applicator and cats weighing >2.5-7.5 kg received one 0.9 mL applicator. For determination of the efficacy of treatments, lungworm larval counts were established on faecal samples collected from all cats 32, 39, 46, 53 and 60 dpi. At each occasion from 46 dpi on, cats treated with fipronil, (S)-methoprene, eprinomectin and praziquantel had significantly lower A. abstrusus larval counts than the untreated controls with percentage reductions of 91.6% (cats treated 14dpi; P=0.012), ? 98.9% (cats treated either 4 dpi, 7 dpi or 32 dpi; P<0.001) or >99.9% (cats treated 4 dpi+32 dpi; P<0.001) at 60 dpi. Thus, the novel topical combination of fipronil, (S)-methoprene, eprinomectin and praziquantel was highly effective in the prevention and treatment of A. abstrusus lungworm infection in cats. PMID:24703080

Knaus, Martin; Chester, S Theodore; Rosentel, Joseph; Kühnert, Axel; Rehbein, Steffen

2014-04-28

88

Efficacy and Safety of Different Dosages of Praziquantel for the Treatment of Schistosoma Japonicum: A Systematic Review and Meta-Analysis  

PubMed Central

Background: Praziquantel, an antischistosomal compound, is used as first-line drug for chemotherapy of Schistosoma japonicum since 1984. In this article, we conducted a systematic review and mete-analysis to evaluate the efficacy and safety of different dosages of praziquantel (PZQ) for treatment of Schistosoma japonicum. Evidence Acquisition: A number of six articles published in peer-reviewed journals before December 2012 were selected for analysis after searching the following literature databases: PubMed/Medline, the Chinese WanFang Literature Database, China National Knowledge Infrastructure (1994-2012.12), and the Chinese Biomedical Literature (1978-2012.12). Results: The meta-analyses showed that there is no statistically significant difference of the negative rate on the egg using 40 mg/kg compared to 60 mg/kg PZQ for S. japonicum treatment (RR 0.79, 95% CI 0.46 1.35; P < 0.39). The meta-analysis showed that there is no statistically significant difference of the side effects using 30 mg/kg compared with 40 mg/kg (RR 0.97, 95% CI 0.68 1.38; P = 0.87), 40 mg/kg compared with 60 mg/kg (RR 0.79, 95% CI 0.46 1.35; P = 0.39) and 50 mg/kg compared with 60 mg/kg (RR 0.89, 95% CI 0.56 1.42; P = 0.63). Conclusions: According to the results, there is no statistically significant difference in different doses of PZQ for treating S. japonicum.

Cai, Damin; Zhang, Si; Wu, Julong; Wang, Xun; Wang, Meng; Lu, Xiaoling; Chen, Huiyu; Wang, Qian; Ma, Xingming

2014-01-01

89

Efficacy of a novel topical combination of fipronil, (S)-methoprene, eprinomectin and praziquantel against feline urinary bladder worm (Capillaria plica) infection.  

PubMed

Infection with urinary capillarid bladder worms has been observed in cats worldwide. Although considered as generally causing no or little harm, infection with urinary capillarids may be associated with clinical disease which requires an appropriate treatment including the use of anthelmintics. Therefore, the efficacy of a novel topical combination formulation of fipronil 8.3% (w/v), (S)-methoprene 10% (w/v), eprinomectin 0.4% (w/v), and praziquantel 8.3% (w/v) (BROADLINE(®), Merial) was evaluated against urinary capillarids in naturally infected cats. Sixteen European Short Hair cats (5 male, 11 female) with capillarid eggs in their urine pre-treatment were included in the study. At the time of treatment, the cats were approximately ten months to eight years old and weighed 1.6-3.6 kg. Cats were ranked based on decreasing bodyweight and then randomly allocated within replicates of two animals to one of the treatment groups. Each cat in the treated group received one topical application of the combination product at the minimum therapeutic dose of 0.12 mL/kg body weight delivering 10mg fipronil+12 mg (S)-methoprene+0.5mg eprinomectin+10mg praziquantel per kilogram of body weight while the cats allocated to the control group remained untreated. For parasite recovery, identification and count, cats were euthanized humanely 14 days after treatment. All untreated cats harboured Capillaria plica in their urinary bladders (range 4-12), while no capillarids were recovered from the eight treated cats. Thus, the efficacy of the novel topical combination against C. plica was 100%. All cats accepted the treatment well based on post-treatment observations and daily observations thereafter. No adverse events or other health problems were observed during the study. PMID:24703076

Knaus, Martin; Shukullari, Enstela; Rosentel, Joseph; Rehbein, Steffen

2014-04-28

90

Efficacy of a novel topical combination of fipronil, (S)-methoprene, eprinomectin and praziquantel against adult and larval stages of Toxocara cati in cats.  

PubMed

The efficacy of a novel topical combination of fipronil 8.3% (w/v), (S)-methoprene 10% (w/v), eprinomectin 0.4% (w/v), and praziquantel 8.3% (w/v) (BROADLINE(®), Merial) was evaluated against adult and larval Toxocara cati in four controlled studies. All studies included experimentally infected, purpose-bred, short-haired cats. In two studies, 22 or 20 cats harbouring patent infections as confirmed by pre-treatment faecal examination, were included. Within each study, cats were allocated to one of two groups: control or treated. In a further two studies, 30 cats were included in each; cats were allocated to one of three groups: control, treated when T. cati were expected to be either migrating third and/or fourth-stage larvae, or treated when T. cati were expected to be fourth-stage larvae. Cats allocated to the treated groups received a single topical application of the combination product at 0.12 mL/kg bodyweight (10mg fipronil+12 mg (S)-methoprene+0.5mg eprinomectin+10mg praziquantel per kg). For parasite recovery and count, cats were euthanized humanely at different intervals after treatment. In the studies targeting adult T. cati, ascarids were recovered from all controls (range 1-150) while only two worms were isolated from one treated cat. Thus, the efficacy of the novel combination was 99.4% and 100% against adult T. cati. For studies targeting larval T. cati, up to 21 worms were recovered from each of seven or eight of the control cats per study. No T. cati were recovered from the treated cats in two studies, corresponding to 100% efficacy against both, migrating third and/or fourth-stage larvae and luminal fourth-stage larvae. All cats accepted the treatment well and no adverse experiences or other health problems were observed throughout the studies. PMID:24703074

Knaus, Martin; Baker, Christine F; Reinemeyer, Craig R; Chester, S Theodore; Rosentel, Joseph; Rehbein, Steffen

2014-04-28

91

Efficacy of a novel topical combination of fipronil, (S)-methoprene, eprinomectin and praziquantel against experimental infections of Toxascaris leonina in cats.  

PubMed

The efficacy of a novel topical fipronil, (S)-methoprene, eprinomectin and praziquantel combination product (BROADLINE(®), Merial) was evaluated against adult Toxascaris leonina ascarids in experimentally infected cats in two controlled studies under an identical protocol. For each study, 30 nematode-naive, purpose-bred European Short Hair cats were inoculated orally with approximately 300 larvated T. leonina eggs. Twenty-two and 24 cats, respectively, that were shown to be positive for Toxascaris eggs by pre-treatment faecal examination were subsequently included in the two studies. In each study, the animals were allocated randomly to an untreated (control) group or to a treatment group. The treatment was a novel topical combination: fipronil (8.3%, w/v), (S)-methoprene (10%, w/v), eprinomectin (0.4% w/v) and praziquantel (8.3% w/v). Treatment was applied on Day 0 at 0.12 mL/kg bodyweight. For parasite recovery and count, cats were euthanized humanely seven days after treatment and necropsied. All untreated cats harboured adult T. leonina (range, 1-31 nematodes). The treatment provided a high level of efficacy against adult T. leonina in both studies (95.8% and 98.1%, respectively p<0.001). All cats accepted the treatment well based on hourly post-treatment observations for 4h and daily observations thereafter. No adverse experiences or other health problems were observed throughout the studies. Thus the data indicate that this novel combination product will provide a safe and effective treatment against T. leonina in cats. PMID:24703075

Knaus, Martin; Theodore Chester, S; Rosentel, Joseph; Visser, Martin; Rehbein, Steffen

2014-04-28

92

A modified critical test and its use in two dose titration trials to assess efficacy of praziquantel for Anoplocephala perfoliata in equids.  

PubMed

Aims of this study with 43 equids naturally infected with Anoplocephala perfoliata in two dose titration trials were to document (i) the usefulness of a critical test with a 48 h treatment to necropsy period, (ii) efficacy of an oral paste of 0.5-2.0 mg praziquantel/kg body weight, and (iii) when after treatment would fecal egg counts provide best estimates of the tapeworm's prevalence in a herd. All feces passed by an equid after treatment and collected in successive 12 h batches were examined for tapeworms. At necropsy, tapeworms were identified as attached to the mucosa or unattached. Tapeworms were examined with a stereoscope and identified as normal or abnormal. Fecal samples were taken for egg counts at treatment and at 6 h intervals thereafter. In 32 of 36 treated equids, efficacy was 100% and mean efficacies for 0.5, 1.0, 1.5 and 2.0 mg praziquantel/kg body weight were 85.5, 99.7, 100 and 100%, respectively. Two equids treated with 0.5 mg praziquantel/kg body weight had low efficacies (5.4 and 38.1%) and normal tapeworms were found attached in the ventral colon and in one equid also in the dorsal colon. In seven untreated equids, tapeworms were primarily in the cecum with 21.3% detached. "Major fragments" or worms without a scolex but otherwise nearly a complete worm were 20.5% of the number of intact worms; they were not included in the efficacy analysis but should be. If the two equids with low efficacy were eliminated and if the number of all tapeworms and major fragments are combined less than 0.5% were in feces within 12 h of treatment, about 20% were in the 12-24 h period, 42% in 24-36h, 24% in 36-48 h and 13.5% in the equids at necropsy. One horse passed all its tapeworms in 24 h. This 48 h test when compared with a 24 h one with no examination of feces was more efficient in use of trial animals and reduced underestimation and overestimation of efficacy. However, a protocol similar to the 48 h test but with a 24 or 36 h post-treatment period should be investigated. The mean egg count peaked 18-24 h after treatment and samples taken at that time would provide the best estimate of prevalence. The Cornell-Wisconsin centrifugal flotation technique had a specificity of 100% and at 18 and 24 h its sensitivity was 94%. A brief discussion on critical and controlled tests for assessing efficacy of an anthelmintic for A. perfoliata is presented. PMID:16309843

Slocombe, J Owen D

2006-03-15

93

ISSN 0103-9741 Monografias em Cincia da Computao  

E-print Network

abordagem por reflexão computacional baseada em lógica Dárlinton Barbosa Feres Carvalho Edward Hermann Lucena Dezembro, 2010 Análise de Riscos em Projetos: uma abordagem por reexão computacional baseada em em um projeto, é proposto neste trabalho um modelo para reexão computacional baseado em lógica

Endler, Markus

94

Efficacy of praziquantel treatment of schistosomiasis in a non-endemic country: a follow-up of parasitological, clinical and immunological parameters.  

PubMed

Schistosomiasis patients were immigrants to Czechoslovakia from Angola and Yemen. Most of them had light or moderate infections and felt subjectively healthy. They received treatment with praziquantel (two doses with a total of 40 mg/kg) and were followed up for several years. In nine of 13 patients, Schistosoma haematobium or S. mansoni eggs with undamaged miracidia were detected in biopsies from the bladder or the rectum one year or later after treatment. Granulomatous reactions in the rectum and bladder lesions of stage 1 including thickened bladder walls persisted in most of the patients. Antibody levels against adult S. mansoni worm antigen remained elevated for at least two years after therapy in some patients and declined in others. Among the nine patients, for whom pre- and post-treatment sera were available, the changes in relative levels of antibodies did not strictly correlate with the continued presence of schistosome eggs in, or their absence from, biopsies. We discuss the results obtained with sensitive diagnostic techniques in the absence of subjectively perceived disease. PMID:1300350

Giboda, M; Loudová, J; Shonová, O; Boucková, E; Horácek, J; Numrich, P; Ruppel, A; Vítovec, J; Lukes, S; Noll, P

1992-01-01

95

Schistosoma mansoni and S. japonicum: decline of antibodies against diagnostic adult worm antigens (Sm31/32) following praziquantel treatment of mice.  

PubMed

Mice were infected with 10, 100 or 200 cercariae of Schistosoma mansoni or S. japonicum and treated between one and two months later with two doses of praziquantel. At this time, the animals had high levels of antibodies against the adult worm proteins Sm31/32 (schistosome cathepsin B and haemoglobinase). Antibody levels were followed up for about one more year by Western blots and ELISA using purified Sm31/32. Among the 34 surviving mice perfused at the end of the experiments, 14 had between 1 and 4 and one mouse had 8 residual stunted worms. In most mice without detectable worms, anti-Sm31/32 antibodies started to drop within a few months after therapy. In other animals of this group and in those harbouring residual worms, the decrease in titers was not observed or less pronounced. Thus, the presence of even one stunted worm was sufficient to induce continued high titres of antibodies. Decreasing levels of antibody against Sm31/32, however, reflected complete elimination of schistosomes. PMID:1796226

Ruppel, A; Xing, Y; Dell, R; Numrich, P; Shi, Y E

1991-12-01

96

Efficacy of bath and orally administered praziquantel and fenbendazole against Lepidotrema bidyana Murray, a monogenean parasite of silver perch, Bidyanus bidyanus (Mitchell).  

PubMed

We investigated the efficacy of praziquantel (PZQ) and fenbendazole (FBZ), each administered by bath and orally, against the monogenean Lepidotrema bidyana Murray, a gill parasite of the freshwater fish silver perch, Bidyanus bidyanus (Mitchell). PZQ and FBZ were each administered by bath at 10 mg L?¹ for 48 h and on surface-coated feed pellets at 75 mg kg?¹ per body weight (BW) per day for 6 days. Bath treatments of PZQ and FBZ had an efficacy of 99% and 91%, respectively, against adult L. bidyana. Oral treatments of PZQ and FBZ had an efficacy of 79% and 95%, respectively, against adult L. bidyana. Fish rejected feed pellets surface-coated with PZQ, suggesting that palatability of surface-coated PZQ-medicated feed is poor, which undermined efficacy. In all trials, some juvenile parasites were present on fish after treatment during efficacy assessment, indicating that efficacy may be lower against juvenile parasites or that recruitment occurred post-treatment, demonstrating that repeat treatments are necessary to effectively control L. bidyana in aquaculture. PMID:23488766

Forwood, J M; Harris, J O; Deveney, M R

2013-11-01

97

Treatment of schistosomiasis in African infants and preschool-aged children: downward extension and biometric optimization of the current praziquantel dose pole  

PubMed Central

Summary To facilitate administration of praziquantel (PZQ) to African infants and preschool-aged children using a dose pole, the performance of two downwardly extended versions (the first created in 2010 using biometric data from Uganda alone and the second version created here using data from 36 countries) was assessed against height/weight data from a total of 166 210 preschool-aged children (?6 year olds) from 36 African countries. New and optimized thresholds for PZQ tablet administration at one tablet (600 mg), ¾ and ½ tablet divisions are suggested here. Both dose poles investigated estimated an acceptable PZQ dosage (30–60 mg/Kg) for more than 95% of children. Extension and optimization of the current PZQ dose pole, followed by theoretical validation using biometric data from preschool-aged children (0–6 years of age, 60–110 cm in height) from 36 African countries will help future mass drug administration campaigns incorporate younger children. This newly optimized dose pole with single 600 mg (height: 99–110 cm), ¾ (height: 83–99 cm) and ½ (height: 66–83 cm) tablet divisions, also reduces drug waste and facilitates inclusion of preschool-aged children. Our findings also have bearings on the use of other dose poles for treatment of young children. PMID:22876272

Sousa-Figueiredo, José C.; Betson, Martha; Stothard, J. Russell

2012-01-01

98

Treatment of intestinal schistosomiasis in Ugandan preschool children: best diagnosis, treatment efficacy and side-effects, and an extended praziquantel dosing pole  

PubMed Central

Summary The Ugandan national control programme for schistosomiasis has no clear policy for inclusion of preschool-children (?5 years old) children. To re-balance this health inequality, we sought to identify best diagnosis of intestinal schistosomiasis, observe treatment safety and efficacy of praziquantel (PZQ), and extend the current WHO dose pole for chemotherapy. We examined and treated 363 preschool children from shoreline villages of Lakes Albert and Victoria, and found that 62·3% (CI95 57·1–67·3) of the children were confirmed to have intestinal schistosomiasis. One day after treatment, children were reported as having headaches (3·6%), vomiting (9·4%), diarrhoea (10·9%) and urticaria/rash (8·9%) with amelioration at 21-day follow-up, where the parasitological cure rate was found to be 100·0%. Height and weight data were collected from a further 3303 preschool children to establish and validate an extended PZQ dose pole that now includes two new height-intervals: 60–84 cm for one-half tablet and 84–99 cm for three-quarter tablet divisions; which would result in 97·6% of children receiving an acceptable dose (30–60 mg/kg). To conclude, preschool children in lakeshore communities of Uganda are at significant risk of intestinal schistosomiasis; we now strongly advocate for their immediate inclusion within the national control programme to eliminate this health inequity. PMID:20640034

Sousa-Figueiredo, José Carlos; Pleasant, Joyce; Day, Matthew; Betson, Martha; Rollinson, David; Montresor, Antonio; Kazibwe, Francis; Kabatereine, Narcis B.; Stothard, J. Russell

2010-01-01

99

Closing the praziquantel treatment gap: new steps in epidemiological monitoring and control of schistosomiasis in African infants and preschool-aged children  

PubMed Central

SUMMARY Where very young children come into contact with water containing schistosome cercariae, infections occur and schistosomiasis can be found. In high transmission environments, where mothers daily bathe their children with environmentally drawn water, many infants and preschool-aged children have schistosomiasis. This ‘new’ burden, inclusive of co-infections with Schistosoma haematobium and Schistosoma mansoni, is being formally explored as infected children are not presently targeted to receive praziquantel (PZQ) within current preventive chemotherapy campaigns. Thus an important PZQ treatment gap exists whereby infected children might wait up to 4–5 years before receiving first treatment in school. International treatment guidelines, set within national treatment platforms, are presently being modified to provide earlier access to medication(s). Although detailed pharmacokinetic studies are needed, to facilitate pragmatic dosing in the field, an extended ‘dose pole’ has been devised and epidemiological monitoring has shown that administration of PZQ (40 mg/kg), in either crushed tablet or liquid suspension, is both safe and effective in this younger age-class; drug efficacy, however, against S. mansoni appears to diminish after repeated rounds of treatment. Thus use of PZQ should be combined with appropriate health education/water hygiene improvements for both child and mother to bring forth a more enduring solution. PMID:21861945

STOTHARD, J. RUSSELL; SOUSA-FIGUEIREDO, JOSÉ C.; BETSON, MARTHA; GREEN, HELEN K.; SETO, EDMUND Y. W.; GARBA, AMADOU; SACKO, MOUSSA; MUTAPI, FRANCISCA; VAZ NERY, SUSANA; AMIN, MUTAMAD A.; MUTUMBA-NAKALEMBE, MARGARET; NAVARATNAM, ANNALAN; FENWICK, ALAN; KABATEREINE, NARCIS B.; GABRIELLI, ALBIS F.; MONTRESOR, ANTONIO

2011-01-01

100

Efficacy of a novel topical combination of fipronil, (S)-methoprene, eprinomectin and praziquantel against induced infections of Ancylostoma spp. nematodes of cats.  

PubMed

Four studies were conducted to examine the efficacy of a novel topical combination of fipronil, (S)-methoprene, eprinomectin, and praziquantel (BROADLINE(®), Merial) against Ancylostoma tubaeforme and Ancylostoma braziliense hookworms of cats. In each study, purpose-bred cats were randomly assigned to treatment groups of 10 or 12 cats per group. In three studies the cats were inoculated with A. tubaeforme and in one study with A. braziliense. The inoculations were undertaken on a schedule which resulted in the hookworms reaching the fourth larval stage in two of the studies, or the adult stage in four of the studies, by the day of treatment. In each study there was also an untreated control and 1 or 2 groups treated with the novel combination. In the two studies where efficacy against the fourth larval stage of A. tubaeforme was tested, the efficacy recorded was 100%. In the three studies where efficacy against the adult stage of A. tubaeforme was tested, efficacy of 100% was also confirmed. In the study where efficacy against the adult stage of A. braziliense was tested efficacy was 99.5%. PMID:24703073

Prullage, Joseph B; Knaus, Martin; Bowman, Dwight D; Chester, S Theodore; Visser, Martin; Rehbein, Steffen; Rosentel, Joseph

2014-04-28

101

Efficacy of a novel topical combination of fipronil, (S)-methoprene, eprinomectin, and praziquantel, against the ticks, Ixodes ricinus and Ixodes scapularis, on cats.  

PubMed

Five controlled, blinded and randomized studies were conducted to examine the efficacy of a single topical application of a combination of fipronil, (S)-methoprene, eprinomectin, and praziquantel (BROADLINE(®), Merial) against induced infestations with Ixodes ticks on cats. Three studies investigated the efficacy against Ixodes ricinus and two against Ixodes scapularis. In each study, purpose-bred cats were assigned at random to an untreated group or to a treated group. For the studies using I. ricinus, cats were infested with 50 female ticks and a similar number of males 2 days before treatment application, and weekly afterwards on between four and six occasions. For the studies using I. scapularis, cats were infested with a total of 50 ticks (approximately 25 females and 25 males) according to the same schedule as for I. ricinus. Tick counts for the evaluation of efficacy were performed 48 h after treatment and 48 h after the subsequent weekly infestations. Weekly attachment rates to untreated cats of at least 29% for I. ricinus and at least 30% for I. scapularis demonstrated consistently that the ticks were vigorous and that the attachment rates were adequate for efficacy evaluation. In the I. ricinus studies, an efficacy of at least 93% was demonstrated for up to 37 days after the treatment. In the I. scapularis studies, the efficacy level was at least 95% 30 days after the treatment. The product was well tolerated and caused no adverse reaction. PMID:24703079

Tielemans, E; Prullage, J; Knaus, M; Visser, M; Manavella, C; Chester, S T; Young, David; Everett, William R; Rosentel, J

2014-04-28

102

Closing the praziquantel treatment gap: new steps in epidemiological monitoring and control of schistosomiasis in African infants and preschool-aged children.  

PubMed

Where very young children come into contact with water containing schistosome cercariae, infections occur and schistosomiasis can be found. In high transmission environments, where mothers daily bathe their children with environmentally drawn water, many infants and preschool-aged children have schistosomiasis. This 'new' burden, inclusive of co-infections with Schistosoma haematobium and Schistosoma mansoni, is being formally explored as infected children are not presently targeted to receive praziquantel (PZQ) within current preventive chemotherapy campaigns. Thus an important PZQ treatment gap exists whereby infected children might wait up to 4-5 years before receiving first treatment in school. International treatment guidelines, set within national treatment platforms, are presently being modified to provide earlier access to medication(s). Although detailed pharmacokinetic studies are needed, to facilitate pragmatic dosing in the field, an extended 'dose pole' has been devised and epidemiological monitoring has shown that administration of PZQ (40 mg/kg), in either crushed tablet or liquid suspension, is both safe and effective in this younger age-class; drug efficacy, however, against S. mansoni appears to diminish after repeated rounds of treatment. Thus use of PZQ should be combined with appropriate health education/water hygiene improvements for both child and mother to bring forth a more enduring solution. PMID:21861945

Stothard, J Russell; Sousa-Figueiredo, José C; Betson, Martha; Green, Helen K; Seto, Edmund Y W; Garba, Amadou; Sacko, Moussa; Mutapi, Francisca; Vaz Nery, Susana; Amin, Mutamad A; Mutumba-Nakalembe, Margaret; Navaratnam, Annalan; Fenwick, Alan; Kabatereine, Narcis B; Gabrielli, Albis F; Montresor, Antonio

2011-10-01

103

Uma aplicação Web para análise de exames Cardio- Respiratórios  

Microsoft Academic Search

This paper describes a web-application in development to help on the analysis of cardiorespiratory system of health and pathological subjects. The software helps health professionals in rehabilitation tasks as also in prevention of cardiorespiratory diseases. Resumo. Este artigo descreve uma aplicação web em desenvolvimento para auxiliar na análise e interpretação de resultados de exames que avaliam o sistema cardiorrespiratório de

Maria Angelica de Oliveira; Camargo Brunetto; André Luis Debiaso Rossi

104

Uma Ferramenta para a Composio de "Vdeos Interativos"  

E-print Network

a Internet/Web, a multimídia, os jogos por computador, e outras tecnologias que em poucos anos passaram por, sem uma representação adequada de aspectos da narrativa. Ao contrário disso, nos jogos, por exemplo, exatamente como fazem os jogos. Portanto, os problemas de interatividade e engajamento por si só també

Barbosa, Alberto

105

A Minha Biblioteca uma empresa formada pelo consrcio  

E-print Network

livros acadêmicos do Brasil: #12;· As quatro editoras oferecem em uma única plataforma acesso online a um extenso acervo de livros técnicos, científicos e profissionais de qualidade reconhecida nacionalmente. · Através da plataforma Minha Biblioteca alunos e docentes terão acesso a mais de 5.030 livros de diversas

Floeter, Sergio Ricardo

106

Aprendizagem colaborativa com suporte computacional: Uma perspectiva histórica  

Microsoft Academic Search

A Aprendizagem Colaborativa com Suporte Computacional (CSCL) é um ramo emergente das ciências da aprendizagem que estuda como as pessoas podem aprender em grupo com o auxílio do computador. Como será visto neste artigo, até mesmo esta simples sentença esconde uma complexidade considerável. A interação da aprendizagem com a tecnologia revela-se bastante complexa. A inclusão da colaboração, da mediação pelo

Gerry Stahl; Timothy Koschmann; Dan Suthers

107

A Gestão Estratégica das Instituições de Ensino Superior: uma contribuição ao melhor desempenho no caso brasileiro  

Microsoft Academic Search

Resumo: O crescimento no número de instituições de Ensino Superior no Brasil tem provocado inadequações, decorrentes da má gestão e do baixo comprometimento em relação à qualidade do processo educacional. O não alinhamento da educação superior com políticas de desenvolvimento e a falta de uma efetiva regulamentação institucional, no atendimento às demandas regionais, representam uma grave dispersão de esforços e

Alfredo Colenci Júnior; Ana Lúcia Spigolon; Marco Anselmo de Godoi; Maria Elizete Luz Sáes

108

Uma Ferramenta de Monitoramento de Redes usando Sistemas Gerenciadores de Streams de Dados  

E-print Network

Uma Ferramenta de Monitoramento de Redes usando Sistemas Gerenciadores de Streams de Dados Natascha uma ferramenta gen´erica de monitoramento de redes utilizando um Sistema Gerenciador de Streams de¸~oes e topologias de rede, considerando tamb´em diver- sos objetivos de monitoramento. As medic¸~oes s

Hara, Carmem Satie

109

[Long-term impact of a mass treatment by praziquantel on morbidity due to Schistosoma haematobium in two hyperendemic villages of Niger].  

PubMed

Although it is established that the treatment by praziquantel reduces the urinary lesions due to Schistosoma haematobium, the frequency of mass treatment necessary to maintain a low morbidity level remains poorly known. The objective of this work was to study the impact over three years of a single praziquantel mass treatment on schistosomiasis morbidity in two different systems of disease transmission in Niger. The study was performed in 2 villages hyperendemic for schistosomiasis in the South-West of Niger presenting respectively 2 different systems of schistosomiasis transmission: Koutoukalé-Zéno (K Zéno), located close to an irrigated area of the Niger River Valley where the transmission is permanent, and Téguey located along a temporary pond where the transmission is seasonal. After the initial evaluation (1994), we carried out a survey 3 years later (1997) except in K. Zéno where an intermediate evaluation was performed 10 months after the initial survey (1995). Approximately 300 randomised people have been examined as follows: macroscopic examination of urine and reagent sticks for macro- and micro-haematuria, filtration and microscopic examination of urine for Schistosoma eggs, and ultrasound scan of the urinary tract for morbidity. The therapeutic coverage has reached 69.9% in K. Zéno and 78.2% in Téguey. The prevalence of infestation decreased from 74.1% to 56.4 % in K. Zéno (p < 0.001) and from 65.3% to 30.4% in Téguey (p < 0.001) at the end of the 3 years. The prevalence of heavy infestation (eggs > or = 50) went in the same time from 9.9% to 12.8% (p = 0.3) in K. Zéno and from 9.1% to 3.3% in Téguey (p = 0.01). Using ultrasound scan, the prevalence of the bladder lesions reached its previous level in both villages. However the prevalence of hydronephrosis decreased from 21.1% to 3.9% in K. éno (p < 0.001) and from 12.6% to 4.2% in Téguey (p < 0.001). Three years after the single mass treatment, the morbidity did not reach the initial level. The effectiveness of the treatment is better in the pond system where the transmission is seasonal. The lesions of the upper tract decreased more slowly than the bladder lesions, but a long time after the treatment. The re-infestation induced the re-appearance of the bladder lesions sooner than the lesions of the upper tract. The periodicity of the treatment should be variable according to the transmission system. It should occur every 2 years in irrigated areas and could be delayed (3 years) in temporary ponds. The control was beneficial in the pond system and induced a significant reduction of the severe lesions. PMID:15104149

Garba, A; Campagne, G; Tassie, J M; Barkire, A; Vera, C; Sellin, B; Chippaux, J P

2004-02-01

110

Efficacy of praziquantel in the treatment of Schistosoma haematobium infection among school-age children in rural communities of Abeokuta, Nigeria  

PubMed Central

Background Chemotherapy with praziquantel (PZQ) has been the cornerstone of schistosomiasis control over the last two decades. Being the only available drug for the treatment of over 200 million people worldwide, continuous monitoring of PZQ efficacy under the pressure of widespread use is therefore advocated. Methods The efficacy of taking two doses of oral PZQ for the treatment of Schistosoma haematobium was examined among school children in Nigeria. Urine specimens were collected from 350 school children and examined using the filtration technique. Blood was collected for packed cell volume (PCV) estimation, and the weight and height of each child were estimated. S. haematobium egg positive pupils were treated with two oral doses of PZQ at 40 mg/kg with a four-week interval in between. Drug efficacy was determined based on the egg reduction rate (ERR). Results Among 350 school children, 245 (70.0%) – of which 132 were males and 113 were females, with an age range of 4 to 15 years – were diagnosed with S. haematobium. All the 245 infected children received a single oral dose of 40 mg/kg PZQ twice with a four-week interval in between and were followed up for 12 weeks. At four, eight and twelve weeks post treatment, the ERR was 57.1%, 77.6% and 100%, respectively. The ERR was significantly higher among the children with a light infection compared to those with a heavy infection. One hundred and twenty-one children were egg negative at four weeks post treatment, among which 1 (6.3) and 120 (52.4%) had heavy and light infections, respectively. Following the second round of treatment, the cure rate at eight weeks and twelve weeks was 85.3% and 100%, respectively. Conclusion This study demonstrated the efficacy of taking two doses of oral PZQ for the treatment of urinary schistosomiasis among school children in Nigeria. PMID:25215186

2014-01-01

111

Factors associated with coverage of praziquantel for schistosomiasis control in the community-direct intervention (CDI) approach in Mali (West Africa)  

PubMed Central

Background Despite the progress made in the control of Neglected Tropical Diseases (NTD), schistosome and soil-transmitted helminth infections are far from being effectively managed in many parts of the world. Chemotherapy, the key element of all control strategies, is faced with some difficulties in terms of access to treatment. Our study aims to describe the factors involved in the success or failure of the community-directed intervention (CDI) approach through control programmes, which aims to achieve consistent high coverage at affordable and sustainable costs in endemic areas. Methods The CDI approach was carried out from December 2007 to October 2008 in ten villages of the district of Diéma, Mali. At inclusion, each child part of the study’s sample was interviewed and submitted for a physical examination. The study focused on: data collection, treatment of the eligible population, evaluation of the treatment coverage, performance of community drug distributors (CDDs), and the involvement and perception of populations. Results A total of 8,022 eligible people were studied with a mean coverage rate of 76.7%. Using multiple regression, it was determined that receiving praziquantel as treatment was associated with five factors: belonging to the Fulani or Moorish ethnic minority versus the Bambara/Soninke, use of the central versus the house-to-house drug distribution mode, the ratio of the population to the number of CDDs, the lack of supervision and belonging to the age group of 15 years or above (p<0.05). As well as that, it was found that the presence of parallel community-based programmes (HIV, tuberculosis) that provide financial incentives for community members discouraged many CDDs (who in most cases are volunteers) to participate in the CDI approach due to a lack of incentives. Conclusions The findings indicate that the success of the CDI approach depends on, amongst other things, the personal characteristics of the respondents, as well as on community factors. PMID:23849481

2013-01-01

112

The impact of single versus mixed schistosome species infections on liver, spleen and bladder morbidity within Malian children pre- and post-praziquantel treatment  

PubMed Central

Background In the developing world co-infections and polyparasitism within humans appear to be the rule rather than the exception, be it any combination of inter-specific and/or inter- and intra-Genera mixed infections. Mixed infections might generate synergistic or antagonistic interactions and thereby clinically affect individuals and/or impact parasite epidemiology. Methods The current study uniquely assesses both Schistosoma mansoni- and Schistosoma haematobium-related morbidity of the liver and the bladder as assessed by ultrasound as well as spleen and liver morbidity through clinical exams. The impact of praziquantel (PZQ) treatment on such potential inter-specific schistosome interactions and resulting morbidity using uniquely detailed longitudinal data (pre- and one year post-PZQ treatment) arising from the National Schistosomiasis Control Program in three areas of Mali: Ségou, Koulikoro and Bamako, is also evaluated. At baseline, data were collected from up to 2196 children (aged 7-14 years), 844 of which were infected with S. haematobium only, 124 with S. mansoni only and 477 with both. Follow-up data were collected from up to 1265 children. Results Results suggested lower liver morbidity in mixed compared to single S. mansoni infections and higher bladder morbidity in mixed compared to single S. haematobium infections. Single S. haematobium or S. mansoni infections were also associated with liver and spleen morbidity whilst only single S. haematobium infections were associated with bladder morbidity in these children (light S. haematobium infection OR: 4.3, p < 0.001 and heavy S. haematobium infection OR: 19, p < 0.001). PZQ treatment contributed to the regression of some of the forms of such morbidities. Conclusions Whilst the precise biological mechanisms for these observations remain to be ascertained, the results illustrate the importance of considering mixed species infections in any analyses of parasite-induced morbidity, including that for the proposed Disability Adjusted Life Years (DALYs) revised estimates of schistosomiasis morbidity. PMID:20670408

2010-01-01

113

Efficacy of a novel topical combination of fipronil, (S)-methoprene, eprinomectin and praziquantel against adult and immature stages of the cat flea (Ctenocephalides felis) on cats.  

PubMed

The efficacy of a novel topical combination of fipronil 8.3% (w/v), (S)-methoprene 10% (w/v), eprinomectin 0.4% (w/v) and praziquantel 8.3% (w/v) (BROADLINE(®)) was tested against adult and immature stages of Ctenocephalides felis fleas in six studies. For that purpose, fleas from different colonies from North America, Germany and South Africa were used to induce infestations in cats under laboratory conditions. In each study, between 12 and 16 cats were allocated randomly to 2 groups. Cats in Group 1 were not treated and served as controls. Cats in Group 2 were treated once on Day 0 with BROADLINE(®) at the minimum recommended dosage of 0.12 mg/kg body weight. In 4 studies, all animals were infested experimentally with unfed C. felis (100 ± 5) on Days 2 (or 1), 7, 14, 21, 28 and 35. Live fleas were counted 24h post-treatment or infestation. In 2 additional studies, animals were infested at the same frequency with gravid C. felis fleas (100 ± 5) that were fed previously on an untreated host. Forty-eight hours post-infestation, flea eggs were collected, counted and incubated for the evaluation of the reduction of emergence of adults. The combined curative efficacy against adult fleas at 24h after treatment was 94.3% and the combined preventive efficacy values remained greater than 95.9% at 24h after 5 subsequent weekly infestations. In addition, the product reduced dramatically the emergence of new adult fleas for at least 5 weeks (>98.1% for one month and 93.2% at 5 weeks after infestation), demonstrating its efficiency in preventing environmental contamination by immature stages. PMID:24703078

Baker, Christine; Tielemans, Eric; Prullage, Joseph B; Chester, S Theodore; Knaus, Martin; Rehbein, Steffen; Fourie, Josephus J; Young, David R; Everett, William R; Rosentel, Joseph K

2014-04-28

114

Preventive efficacy of a topical combination of fipronil – (S)-methoprene – eprinomectin – praziquantel against ear mite (Otodectes cynotis) infestation of cats through a natural infestation model  

PubMed Central

A study based on naturally infested cats was designed to evaluate the effectiveness of a single treatment with a topical formulation containing fipronil, (S)-methoprene, eprinomectin and praziquantel, for the prevention of Otodectes cynotis infestation in cats. Six treated cats and six untreated cats were housed with three chronically Otodectes cynotis-infested cats, respectively. The cats of each group were kept together in a 20-m2 room for 1 month. Both clinical examination and ear mite counts were conducted on Day 28. All donor cats were confirmed to be chronically infested with Otodectes cynotis on Day ?1 and Day 28. From untreated control cats, 129 live mites were recovered on Day 28 and all cats were found to be infested. In the treated group, three cats were found to be infested, with a total of five live mites recovered, the difference between the two groups being significant (p = 0.003). One treatment corresponded to 96% preventive efficacy at Day 28 based on ear mite counts. With regard to cerumen, the clinical score increased significantly for untreated cats between Day ?1 and Day 28 (p = 0.00026) and not for treated cats (p = 0.30). The difference in cerumen abundance was significant between untreated and treated cats on Day 28 (p = 0.0035). Concerning the pruritic reflex in at least one ear, all cats were negative at inclusion. All six untreated cats became positive and showed a reflex on Day 28, whereas no treated cat showed ear pruritus (p = 0.00026). PMID:25148648

Beugnet, Frédéric; Bouhsira, Émilie; Halos, Lénaïg; Franc, Michel

2014-01-01

115

A Latent Markov Modelling Approach to the Evaluation of Circulating Cathodic Antigen Strips for Schistosomiasis Diagnosis Pre- and Post-Praziquantel Treatment in Uganda  

PubMed Central

Regular treatment with praziquantel (PZQ) is the strategy for human schistosomiasis control aiming to prevent morbidity in later life. With the recent resolution on schistosomiasis elimination by the 65th World Health Assembly, appropriate diagnostic tools to inform interventions are keys to their success. We present a discrete Markov chains modelling framework that deals with the longitudinal study design and the measurement error in the diagnostic methods under study. A longitudinal detailed dataset from Uganda, in which one or two doses of PZQ treatment were provided, was analyzed through Latent Markov Models (LMMs). The aim was to evaluate the diagnostic accuracy of Circulating Cathodic Antigen (CCA) and of double Kato-Katz (KK) faecal slides over three consecutive days for Schistosoma mansoni infection simultaneously by age group at baseline and at two follow-up times post treatment. Diagnostic test sensitivities and specificities and the true underlying infection prevalence over time as well as the probabilities of transitions between infected and uninfected states are provided. The estimated transition probability matrices provide parsimonious yet important insights into the re-infection and cure rates in the two age groups. We show that the CCA diagnostic performance remained constant after PZQ treatment and that this test was overall more sensitive but less specific than single-day double KK for the diagnosis of S. mansoni infection. The probability of clearing infection from baseline to 9 weeks was higher among those who received two PZQ doses compared to one PZQ dose for both age groups, with much higher re-infection rates among children compared to adolescents and adults. We recommend LMMs as a useful methodology for monitoring and evaluation and treatment decision research as well as CCA for mapping surveys of S. mansoni infection, although additional diagnostic tools should be incorporated in schistosomiasis elimination programs. PMID:24367250

Koukounari, Artemis; Donnelly, Christl A.; Moustaki, Irini; Tukahebwa, Edridah M.; Kabatereine, Narcis B.; Wilson, Shona; Webster, Joanne P.; Deelder, André M.; Vennervald, Birgitte J.; van Dam, Govert J.

2013-01-01

116

Estudo comparativo dos parâmetros angulares da marcha humana em ambiente aquático e terrestre em indivíduos hígidos adultos jovens  

Microsoft Academic Search

RESUMO Há um grande interesse em estudar o movimento humano den- tro da água, uma vez que o meio já é utilizado para treinamento e reabilitação devido às diferentes propriedades mecânicas que ofe- rece. No entanto, há uma carência de estudos sobre as caracterís- ticas biomecânicas do andar em ambiente aquático. O presente estudo teve como objetivo determinar as variáveis

Danieli Isabel Romanovitch Ribas; Vera Lúcia Israel; Elisângela Ferretti Manfra; Camila Costa de Araújo

2007-01-01

117

Efficacy and safety of two closely spaced doses of praziquantel against Schistosoma haematobium and S. mansoni and re-infection patterns in school-aged children in Niger.  

PubMed

The aim of this study was to assess the efficacy and safety of two closely spaced doses of praziquantel (PZQ) against Schistosoma haematobium and S. mansoni infection in school-aged children, and to characterise re-infection patterns over a 12-month period. The study was carried out in five villages in western Niger: Falmado, Seberi and Libore (single S. haematobium infection foci), and Diambala and Namarigoungou (mixed S. haematobium-S. mansoni infection foci). Parasitological examinations consisted of triplicate urine filtrations and triplicate Kato-Katz thick smears at each visit. Two 40mg/kg oral doses of PZQ were administered 3 weeks apart. Adverse events were monitored within 4h after dosing by the survey team and 24h after treatment using a questionnaire. Our final study cohort comprised 877 children who were infected with either S. haematobium, or S. mansoni, or both species concurrently and received both doses of PZQ. Follow-up visits were conducted 6 weeks, 6 months and 12 months after the first dose of PZQ. At baseline, the geometric mean (GM) infection intensity of S. haematobium ranged from 3.6 (Diambala) to 30.3eggs/10ml of urine (Falmado). The GM infection intensity of S. mansoni ranged from 86.7 (Diambala) to 151.4eggs/g of stool (Namarigoungou). Adverse events were reported by 33.0% and 1.5% of the children after the first and second doses of PZQ, respectively. We found cure rates (CRs) in S. haematobium-infected children 3 weeks after the second dose of PZQ ranging between 49.2% (Falmado) and 98.4% (Namarigoungou) and moderate-to-high egg reduction rates (ERRs) (71.4-100%). Regarding S. mansoni, only moderate CRs and ERRs were found (51.7-58.8% in Diambala, 55.2-60.2% in Namarigoungou). Twelve months post-treatment, prevalence rates approached pre-treatment levels, but infection intensities remained low. In conclusion, PZQ, given in two closely spaced doses, is efficacious against S. haematobium, but the low ERR observed against S. mansoni raises concern about mounting PZQ tolerance. PMID:22940014

Garba, Amadou; Lamine, Mariama S; Barkiré, Nouhou; Djibo, Ali; Sofo, Boubacar; Gouvras, Anouk N; Labbo, Rabiou; Sebangou, Hannatou; Webster, Joanne P; Fenwick, Alan; Utzinger, Jürg

2013-11-01

118

Cytokine Responses to the Anti-schistosome Vaccine Candidate Antigen Glutathione-S-transferase Vary with Host Age and Are Boosted by Praziquantel Treatment  

PubMed Central

Background Improved helminth control is required to alleviate the global burden of schistosomiasis and schistosome-associated pathologies. Current control efforts rely on the anti-helminthic drug praziquantel (PZQ), which enhances immune responses to crude schistosome antigens but does not prevent re-infection. An anti-schistosome vaccine based on Schistosoma haematobium glutathione-S-transferase (GST) is currently in Phase III clinical trials, but little is known about the immune responses directed against this antigen in humans naturally exposed to schistosomes or how these responses change following PZQ treatment. Methodology Blood samples from inhabitants of a Schistosoma haematobium-endemic area were incubated for 48 hours with or without GST before (n?=?195) and six weeks after PZQ treatment (n?=?107). Concentrations of cytokines associated with innate inflammatory (TNF?, IL-6, IL-8), type 1 (Th1; IFN?, IL-2, IL-12p70), type 2 (IL-4, IL-5, IL-13), type 17 (IL-17A, IL-21, IL-23p19) and regulatory (IL-10) responses were quantified in culture supernatants via enzyme-linked immunosorbent assay (ELISA). Factor analysis and multidimensional scaling were used to analyse multiple cytokines simultaneously. Principal Findings A combination of GST-specific type 2 (IL-5 and IL-13) and regulatory (IL-10) cytokines was significantly lower in 10–12 year olds, the age group at which S. haematobium infection intensity and prevalence peak, than in 4–9 or 13+ year olds. Following PZQ treatment there was an increase in the number of participants producing detectable levels of GST-specific cytokines (TNF?, IL-6, IL-8, IFN?, IL-12p70, IL-13 and IL-23p19) and also a shift in the GST-specific cytokine response towards a more pro-inflammatory phenotype than that observed before treatment. Participant age and pre-treatment infection status significantly influenced post-treatment cytokine profiles. Conclusions/Significance In areas where schistosomiasis is endemic host age, schistosome infection status and PZQ treatment affect the cellular cytokine response to GST. Thus the efficacy of a GST-based vaccine may also be shaped by the demographic and epidemiological characteristics of targeted populations. PMID:24810615

Bourke, Claire D.; Nausch, Norman; Rujeni, Nadine; Appleby, Laura J.; Trottein, François; Midzi, Nicholas; Mduluza, Takafira; Mutapi, Francisca

2014-01-01

119

Pharmacokinetics and metabolism of eprinomectin in cats when administered in a novel topical combination of fipronil, (S)-methoprene, eprinomectin and praziquantel.  

PubMed

Four studies were conducted to determine the pharmacokinetic characteristics and in vitro metabolism of eprinomectin, a semi-synthetic avermectin, in cats. Pharmacokinetic parameters including bioavailability of eprinomectin were determined in a parallel study design comprised of one group of eight cats which were treated once topically at 0.12 mL/kg bodyweight with BROADLINE(®), a novel combination product (fipronil 8.3% (w/v), (S)-methoprene 10% (w/v), eprinomectin 0.4% (w/v) and praziquantel 8.3% (w/v)), delivering a dose of 0.5mg eprinomectin per kg body weight, and a group of six cats which received 0.4% (w/v) eprinomectin at 0.4 mg/kg bodyweight once by intravenous injection. For cats treated by topical application, the average eprinomectin (B1a component) maximum plasma concentration (Cmax) was 20 ng/mL. The maximum concentrations were reached 24h after dosing in the majority of the animals (six of eight cats). The average terminal half-life was 114 h due to slow absorption ('flip-flop' kinetics). Following intravenous administration the average Cmax was 503 ng/mL at 5 min post-dose, and the mean elimination half-life was 23 h. Eprinomectin was widely distributed with a mean volume of distribution of 2,390 mL/kg, and the clearance rate was 81 mL/h/kg. Mean areas under the plasma concentration versus time curves extrapolated to infinity were 2,100 ngh/mL and 5,160 ngh/mL for the topical and intravenous doses, respectively. Topical eprinomectin was absorbed with an average absolute bioavailability of 31%. In a second parallel design study, the dose proportionality of eprinomectin after single topical administration of BROADLINE(®) was studied. Four groups of eight cats each were treated once topically with 0.5, 1, 2 or 5 times the minimum recommended dose of the combination, 0.12 mL/kg bodyweight. Based on comparison of areas under the plasma concentration versus time curves from the time of dosing to the last time point at which eprinomectin B1a was quantified, and Cmax, dose proportionality was established. In addition, the metabolic pathway of eprinomectin using cat liver microsomes, and plasma protein binding using cat, rat, and dog plasma were studied in vitro. Results of the analyses of eprinomectin B1a described here showed that it is metabolically stable and highly protein bound (>99%), and thus likely to be, as with other species, excreted mainly as unchanged parent drug in the feces of cats. PMID:24703069

Kvaternick, Valerie; Kellermann, Michael; Knaus, Martin; Rehbein, Steffen; Rosentel, Joseph

2014-04-28

120

Anti-inflammatory/anti-fibrotic effects of the hepatoprotective silymarin and the schistosomicide praziquantel against Schistosoma mansoni-induced liver fibrosis  

PubMed Central

Background Praziquantel (PZQ) is an isoquinoline derivative (2-cyclohexylcarbonyl-1, 2, 3, 6, 7, 11b-hexahydro-4H-pyrazino{2,1-a}-isoquinoline-4-one), and is currently the drug of choice for all forms of schistosomiasis. Silymarin, a standardized milk thistle extract, of which silibinin is the main component, is known for its hepatoprotective, anti-inflammatory, antioxidant activities, and hepatocyte regeneration. This study investigates the anti-inflammatory/anti-fibrotic effects of silymarin and/or PZQ on schistosomal hepatic fibrosis. Methods Schistosoma mansoni-infected mice were divided into two large groups (I & II), each with four subgroups and were run in parallel. (i) Infected untreated; (ii) treated with silymarin, starting from the 4th (3 weeks before PZQ therapy) or 12th (5 weeks after PZQ therapy) weeks post infection (PI); (iii) treated with PZQ in the 7th week PI; and (iv) treated with silymarin, as group (ii) plus PZQ as group (iii). Comparable groups of uninfected mice run in parallel with the infected groups. Mice of groups I and II were killed 10 and 18 weeks PI, respectively. Hepatic content of hydroxyproline (HYP), serum levels and tissue expression of matrix metalloproteinase-2 (MMP-2), transforming growth factor-?1 (TGF-?1) and number of mast cells were determined. In addition, parasitological, biochemical and histological parameters that reflect disease severity and morbidity were examined. Results Silymarin caused a partial decrease in worm burden; hepatic tissue egg load, with an increase in percentage of dead eggs; modulation of granuloma size, with significant reduction of hepatic HYP content; tissue expression of MMP-2, TGF-?1; number of mast cells, with conservation of hepatic reduced glutathione (GSH). PZQ produced complete eradication of worms, eggs and alleviated liver inflammation and fibrosis. The best results were obtained, in most parameters studied, in groups of mice treated with silymarin in addition to PZQ. Conclusions Our results point to silymarin as a promising anti-inflammatory and anti-fibrotic agent; it could be introduced as a therapeutic tool with PZQ in the treatment of schistosomal liver fibrosis, but further studies on mechanisms of silymarin and PZQ in chronic liver diseases may shed light on developing therapeutic methods in clinical practice. PMID:22236605

2012-01-01

121

Efficacy against nematode and cestode infections and safety of a novel topical fipronil, (S)-methoprene, eprinomectin and praziquantel combination product in domestic cats under field conditions in Europe.  

PubMed

A novel topical combination product (BROADLINE(®), Merial) composed of fipronil, (S)-methoprene, eprinomectin and praziquantel was evaluated for safety and efficacy against nematode and cestode infections in domestic cats. The study comprised a multi-centre, positive control, blinded, field study, using a randomized block design based on order of presentation for allocation. In total 196 client-owned cats, confirmed as positive for naturally acquired infections of nematodes and/or cestodes by pre-treatment faecal examination, were studied in seven countries in Europe. Pre-treatment faecal examination revealed the presence of Toxocara, hookworm, Capillaria and/or spirurid nematode infections in 129, 73, 33 or 1 cat(s), respectively; infections with taeniid and Dipylidium cestodes were demonstrated in 39 and 17 cats, respectively. Cats were allocated randomly to one of two treatments in a ratio of 2, topical fipronil (8.3%, w/v), (S)-methoprene (10%, w/v), eprinomectin (0.4%, w/v) and praziquantel (8.3%, w/v) (BROADLINE(®), Merial; 130 cats); and 1, topical PROFENDER(®) Spot-On (Bayer; 66 cats) and treated once on Day 0. For evaluation of efficacy, two faecal samples were collected, one prior to treatment (Day -4 ± 4 days) and one at the end of the study (Day 14 ± 5 days). These were examined for fecal forms of nematode and cestode parasites. For evaluation of safety, cats were examined by a veterinarian before treatment and at the end of the study, and cat owners recorded the health status of their cats daily until the end of the study. For cats treated with Broadline(®), the efficacy was >99.9%, 100%, and 99.6% for Toxocara, hookworms, and Capillaria, respectively; and the efficacy was >99.9%, >99.9%, and 98.5%, respectively, for the cats treated with Profender(®) (p<0.001 for all nematodes and both treatments). Efficacy was 100% for both cestodes for both treatments (p<0.001). No treatment related adverse experiences were observed throughout the study. For both treatments, every cat that completed the study was given a safety score of 'excellent' for both local and systemic evaluations. The topical combination product of fipronil, (S)-methoprene, eprinomectin and praziquantel was shown to have an excellent safety profile and demonstrated high levels of efficacy when administered once as topical solution to cats infected with nematodes and cestodes under field conditions. PMID:24703070

Rehbein, Steffen; Capári, Balazs; Duscher, Georg; Keidane, Dace; Kirkova, Zvezdelina; Petkevi?ius, Saulius; Rapti, Dhimiter; Wagner, Annegret; Wagner, Thomas; Chester, S Theodore; Rosentel, Joseph; Tielemans, Eric; Visser, Martin; Winter, Renate; Kley, Katrin; Knaus, Martin

2014-04-28

122

LIVRO VERDE Por uma Europa sem fumo: opções estratégicas a nível comunitário (apresentado pela Comissão) PT PT ÍNDICE  

E-print Network

1. Considerações em matéria de saúde............................................................................. 5 1.1. Impacto na saúde da exposição ao FTA....................................................................... 5 1.2. Níveis de exposição..................................................................................................... 6 1.3. Impacto de uma iniciativa em prol de zonas sem fumo............................................... 7 2. Considerações de índole económica............................................................................ 7 2.1. Incidências económicas................................................................................................ 7 2.2. Impacto de uma iniciativa em prol de zonas sem fumo............................................... 8 2.3. Eventuais consequências involuntárias........................................................................ 8 3. Considerações de índole social.................................................................................... 9 3.1. Apoio da opinião pública à legislação antitabaco........................................................ 9 3.2. Incidência no consumo de tabaco................................................................................ 9 3.3. Incidência na equidade social....................................................................................... 9 4. Dinâmica de acção..................................................................................................... 10

I. Introdução; Ii. Justificação; Da Acção

2007-01-01

123

Simulao de Evacuao Emergencial Via Autmatos Celulares: Uma Proposta de Modificao do Modelo de Schadschneider  

E-print Network

a teoria de autômatos celulares para a construção de um programa de simulação em linguagem C++, que, alémSimulação de Evacuação Emergencial Via Autômatos Celulares: Uma Proposta de Modificação do Modelo emergencial baseado em simulação por autômatos celulares. Neste trabalho, estudamos o modelo inicialmente

Cruz, Frederico

124

Uma análise do fenômeno “alternância de línguas” na fala de bilíngues intermodais (Libras e Português)  

PubMed Central

Um interessante fenômeno lingüístico presente nas interações das pessoas bilíngues é a alternância de línguas. Neste trabalho, estamos investigando a alternância entre a língua portuguesa oral e a língua de sinais brasileira – Libras, numa mesma cadeia enunciativa, com o objetivo de identificar e analisar o uso dessa alternância na fala de uma criança e de um adulto (ambos ouvintes, filhos de pais surdos), interagindo em uma situação de bilinguismo intermodal, com interlocutores surdos e ouvintes. A alternância de línguas, nesse caso, ocorre quando se para de falar em português e se alterna para sinalizar. O presente trabalho se caracteriza como um estudo inicial, com análise qualitativa de dados. Fazem parte do nosso corpus nove sessões de interações em Libras e em português oral, gravadas em vídeo, que fazem parte do Projeto Desenvolvimento Bilíngue Bimodal da UFSC. Os dados revelam que as características da alternância de línguas pelo adulto e pela criança parecem ter semelhanças e diferenças. O sujeito adulto parece ter feito um uso da alternância mais preocupado com o curso da interação. A criança, por sua vez, não parece tê-la usado com propósitos pragmáticos específicos. Quanto à extensão das alternâncias, pode-se perceber que tanto a criança quanto o adulto utilizaram enunciados maiores do que uma única palavra isolada. O papel dos interlocutores parece ter sido decisivo nas interações aqui investigadas – especialmente nas do adulto, já que a criança ainda está em processo de tomada de consciência do papel do interlocutor na interação. PMID:24379831

de Sousa, Aline Nunes; de Quadros, Ronice Müller

2013-01-01

125

DIAGNÓSTICO DA MECANIZAÇÃO EM UMA REGIÃO PRODUTORA DE GRÃOS1  

Microsoft Academic Search

Besides land, agriculture machinery represents the biggest investment for the farmer and its adjustment to the property size is a basic factor related to cost reduction. However, there is a lack of information that does not make possible the analysis and the comparison about the efficiency of these equipments. Therefore, the objective of this work is to evaluate how it

LEANDRO M. GIMENEZ; MARCOS MILAN

126

Dinâmica populacional de Melanoides tuberculatus (Müller, 1774) em um riacho impactado da Vila do Abraão, Ilha Grande, Angra dos Reis, RJ, Brasil.  

E-print Network

??Melanoides tuberculatus (Müller, 1774) é um gastrópode dulceaquícola de origem afroasiática, atualmente com uma distribuição cosmopolita, devido a seu comportamento invasivo. Utilizamos em nosso trabalho… (more)

Igor Christo Miyahira

2010-01-01

127

BENJAMIN FRANKLIN E A HISTÓRIA DA ELETRICIDADE EM LIVROS DIDÁTICOS  

Microsoft Academic Search

Introdução Nos últimos anos, a história da ciência vem sendo introduzida em materiais didáticos utilizados em sala de aula. Uma das razões para isso é a pressão de órgãos governamentais, tais como a Secretaria de Educação Básica, responsável pela avaliação destes livros dentro do Programa Nacional de Livros Didáticos para o ens ino fundamental e médio. Os editais destes programas

Cibelle Celestino Silva; Ana Carolina Pimentel

128

Suporte para vistas em ambientes de gesto de rede Palavras chave: Vistas, Gesto de Rede, CRC2000.  

E-print Network

1 Suporte para vistas em ambientes de gestão de rede Palavras chave: Vistas, Gestão de Rede, CRC2000. Resumo Em sistemas de gestão de redes, uma vista representa uma perspectiva parcelar do universo sistema Scotty, uma conhecida plataforma de gestão de rede de domínio público. I. Introdução A grande

Rodrigues, Luís E.T.

129

Halema'uma'u Vent Gas Plume  

USGS Multimedia Gallery

Over the past several days, the lava surface within the vent in Halema'uma'u has occasionally, and temporarily, reached to within about 115 m (375 ft) below the floor of Halema'uma'u Crater, as seen in this photo. During these high-lava stands, the gas plume is generally fairly wispy, providing the ...

130

Energy Transfer in W UMa Systems  

NASA Astrophysics Data System (ADS)

W UMa stars consist of two main sequence stars touching each other. Mass and energy is transferred from the primary star to the secondary one throughout the neck between the stars. The rate of the energy transfer is studied. The energy transfer rate depends on the mass and luminosity ratio. A new group of W UMa-type stars is introduced: it is called H-subtype systems meaning high mass ratio systems. They have a mass ratio larger than 0.72 and a different energy transfer rate relation than other types of W UMa systems.

Csizmadia, Szilárd

2005-04-01

131

Discriminação como uma das Fontes de Desigualdade de Rendimentos no Mercado de Trabalho das Regiões Nordeste e Sudeste  

Microsoft Academic Search

Este artigo analisa a discriminação salarial por gênero e raça dentro das densidades das distribuições de salário dos setores de atividade, comparando as regiões Nordeste e Sudeste. Para este objetivo, foram usados os dados da PNAD 2002 e uma metodologia semiparamétrica – estimador de núcleo ponderado e outra paramétrica – regressão quantílica. O primeiro método mostra com base em simulações

Jacqueline Nogueira Cambota; Emerson Luís Lemos Marinho

2007-01-01

132

PROBLEMA, TEORIA E OBSERVAÇÃO EM CIÊNCIA : PARA UMA REORIENTAÇÃO EPISTEMOLÓGICA DA EDUCAÇÃO EM CIÊNCIA  

Microsoft Academic Search

Science teachers play an important role in forming the image of science that is held by their pupils. However, recent research suggests that quite often science teachers conceptions of the nature of scientific knowled- ge are marked by empiricist\\/inductivist epistemologies. Thus, the present paper aims to help science teachers to have a better understanding the epistemology of science aspects which

Daniel Gil-Pérez

2002-01-01

133

Uma arquitetura baseada em agentes para configuração dinâmica de aplicações inteligentes em ambiente foundation fieldbus.  

E-print Network

??The industrial automation is directly linked to the development of information tecnology. Better hardware solutions, as well as improvements in software development methodologies make possible… (more)

Vinicius Ponte Machado

2009-01-01

134

Diagnostic Performance of Schistosoma Real-Time PCR in Urine Samples from Kenyan Children Infected with Schistosoma haematobium: Day-to-day Variation and Follow-up after Praziquantel Treatment  

PubMed Central

Background In an effort to enhance accuracy of diagnosis of Schistosoma haematobium, this study explores day-to-day variability and diagnostic performance of real-time PCR for detection and quantification of Schistosoma DNA compared to other diagnostic tools in an endemic area before and after treatment. Methodology Previously collected urine samples (N?=?390) from 114 preselected proven parasitological and/or clinical S. haematobium positive Kenyan schoolchildren were analyzed by a Schistosoma internal transcribed spacer-based real-time PCR after 14 years of storage. Pre-treatment day-to-day fluctuations of PCR and microscopy over three consecutive days were measured for 24 children using intra-class correlation coefficient. A combined ‘gold standard’ (PCR and/or microscopy positive) was used to measure sensitivity and negative predictive value (NPV) of several diagnostic tools at baseline, two and 18 months post-treatment with praziquantel. Principal Findings All 24 repeatedly tested children were PCR-positive over three days with little daily variation in median Ct-values, while 83.3% were found to be egg-positive for S. haematobium at day 1 and 75.0% at day 2 and 3 pre-treatment, signifying daily fluctuations in microscopy diagnosis. Of all 114 preselected schoolchildren, repeated microscopic measurements were required to detect 96.5% versus 100% of positive pre-treatment cases by single PCR. At two months post-treatment, microscopy and PCR detected 22.8% versus 69.3% positive children, respectively. Based on the ‘gold standard’, PCR showed high sensitivity (>92%) as compared to >31% sensitivity for microscopy, both pre- and post-treatment. Conclusions/Significance Detection and quantification of Schistosoma DNA in urine by real-time PCR was shown to be a powerful and specific diagnostic tool for detection of S. haematobium infections, with less day-to-day variation and higher sensitivity compared to microscopy. The superior performance of PCR before, and two and 18 months post-treatment provides a compelling argument for PCR as an accurate and reproducible tool for monitoring treatment efficacy. PMID:24743389

Vinkeles Melchers, Natalie V. S.; van Dam, Govert J.; Shaproski, David; Kahama, Anthony I.; Brienen, Eric A. T.; Vennervald, Birgitte J.; van Lieshout, Lisette

2014-01-01

135

The accreting white dwarfs in BW Scl, BC UMa and SW UMa  

E-print Network

We have observed the short-period dwarf novae BW Scl, BC UMa and SW UMa using the Hubble Space Telescope/Space Telescope Imaging Spectrograph. In all three systems, the white dwarf is the dominant source of far-ultraviolet flux, even though in BC UMa and SW UMa an additional continuum component contributes ~10% and ~20% of the 1400A flux, respectively. Fitting the data with detailed white dwarf model spectra, we determine the effective temperatures to be 14800+-900K (BW Scl), 15200+-1000K (BC UMa), and 13900+-900K (SW UMa). The additional continuum component in BC UMa and SW UMa is equally well described by either a blackbody or a power law, which could be associated with emission from the hot spot or from an optically thin accretion disk (or an optically thin layer on top of a colder optically thick disk), respectively. Modelling the narrow metal lines detected in the STIS spectra results in sub-solar abundances of carbon, oxygen and silicon for all three systems, and also suggests substantial supra-solar abundances of aluminium. The narrow absorption line profiles imply low white dwarf rotation rates, v sin(i)<=300km/s for the three white dwarfs. SW UMa is the only system that shows significant short-term variability in the far-ultraviolet range, which is primarily associated with the observed emission lines.

B. T. Gaensicke; P. Szkody; S. B. Howell; E. M. Sion

2005-04-18

136

Seminario Informal (mas Formal!) 2006 Estrategias da Teoria de Reescrita em PVS  

E-print Network

4o Semin´ario Informal (mas Formal!) 2006 Estrat´egias da Teoria de Reescrita em PVS: considerac Teoria da Computac¸ ~ao Campus de Catal~ao & Departamento de Matem´atica Universidade Federal de Goi. A especificac¸ ~ao em PVS ´e organizada como uma colec¸ ~ao de Teorias. Uma Teoria ´e essencialmente feita de

Ayala-Rincón, Mauricio

137

The accreting white dwarfs in BW Scl, BC UMa and SW UMa  

E-print Network

We have observed the short-period dwarf novae BW Scl, BC UMa and SW UMa using the Hubble Space Telescope/Space Telescope Imaging Spectrograph. In all three systems, the white dwarf is the dominant source of far-ultraviolet flux, even though in BC UMa and SW UMa an additional continuum component contributes ~10% and ~20% of the 1400A flux, respectively. Fitting the data with detailed white dwarf model spectra, we determine the effective temperatures to be 14800+-900K (BW Scl), 15200+-1000K (BC UMa), and 13900+-900K (SW UMa). The additional continuum component in BC UMa and SW UMa is equally well described by either a blackbody or a power law, which could be associated with emission from the hot spot or from an optically thin accretion disk (or an optically thin layer on top of a colder optically thick disk), respectively. Modelling the narrow metal lines detected in the STIS spectra results in sub-solar abundances of carbon, oxygen and silicon for all three systems, and also suggests substantial supra-solar ab...

Gänsicke, B T; Howell, S B; Sion, E M

2005-01-01

138

Percepção astronómica de um grupo de alunos do ensino médio de uma escola da rede estadual de São Paulo  

NASA Astrophysics Data System (ADS)

Sendo a Astronomia uma das cièncias mais antigas da humanidade, e considerando sua importáncia histórica e cultural, é de extrema releváncia que tópicos relacionados a ela sejam tratados nas escolas. Embora os Parámetros Curriculares Nacionais do Ensino Médio (PCN-EM) e as Orientaçiacute;es Complementares aos Parámetros (PCN+) apontem a importáncia de uma abordagem significativa de conceitos relacionados à Astronomia nas aulas de Física, muitos estudantes terminam o Ensino Médio (EM) sem compreender a razão de certos acontecimentos de origem celeste, ainda que estes façam parte de seu cotidiano e sejam alvos da curiosidade natural dos jovens. Da observação dessa curiosidade em alunos de uma escola pública paulista, na cidade de Suzano, surgiu o interesse em investigar os conhecimentos básicos em Astronomia dos alunos do Ensino Médio desta escola, constituindo-se este como principal objetivo desta pesquisa. Para tanto foi elaborado um questionário de múltipla escolha aplicado inicialmente a 34 alunos do primeiro ano e, posteriormente, a mais 310, distribuídos entre as très séries do Ensino Médio dos períodos matutino e noturno. Dessa forma, observou-se que 73,9% dos estudantes identificaram o Sol como sendo uma estrela, 67,1% mostraram compreender a sucessão entre dia e noite e 52,3% relacionaram o Big Bang à origem do Universo. Em contrapartida, apenas 34,5% relacionaram as estaçíes do ano à inclinação do eixo de rotação da Terra, 21,3% indicaram a influència gravitacional simultánea da Lua e do Sol como responsável pelo fenòmeno das marés, 24,5% indicaram corretamente quais são os objetos celestes mais próximos da Terra, 36,1% identificaram ano-luz como uma medida de distáncia e 34,2% reconheceram as estrelas cadentes como meteoros, evidenciando-se assim o pequeno discernimento dos estudantes quanto aos fenòmenos e termos astronòmicos do cotidiano. Além disso, foram comparadas as respostas de alun! os de diferentes séries e períodos, observando-se, dentre ou tras coi sas, que os estudantes do terceiro ano apresentam um percentual de acertos semelhante ao dos alunos do primeiro, caracterizando que a abordagem de tópicos relacionados à astronomia no Ensino Médio não tem contribuído de forma significativa para uma maior compreensão dos fenòmenos e conceitos.

de Oliveria, E. F.; Voelzke, M. R.

2009-03-01

139

Halema'uma'u Vent Gas Plume  

USGS Multimedia Gallery

The largely crusted surface of the lava lake in the Halema'uma'u vent slowly moves from north (top of the photo) to south. During high lava stands, like that shown here, this circulation is so slow as to be nearly imperceptible to the naked eye....

140

Halema'uma'u Lava Activity  

USGS Multimedia Gallery

Spectacular eruptive activity has been occurring deep within the collapse pit in Halema`uma`u Crater at K?lauea's summit. At times, a river of lava poured into a deeper plunge pool of lava, which had a dome fountain on its right-hand side....

2010-06-21

141

Halema'uma'u Maintains Basic Geometry  

USGS Multimedia Gallery

The lava lake at Halema'uma'u has maintained the same basic geometry since February of this year. This thermal image was taken during a helicopter overflight, and shows the lava surface deep within the vent cavity. The lava surface is kidney-shaped and approximately 60 x 90 meters in size, and situa...

142

DK UMa: A Star on the Ascent  

NASA Technical Reports Server (NTRS)

DK UMa (= 24 UMa = HD 82210) is a G4 IV-III star. According to its M(sub v) and B - V color, it is located at the base of the red giant branch, having recently exited from the Hertzsprung Gap. Now poised to start its first ascent along the giant branch, DK UMa is at a significant juncture in its post-main-sequence evolution, offering an important evolutionary comparison for magnetic activity with stars like 31 Comae, which is just entering the Hertzsprung Gap, and older stars like the Hyades giants or P Ceti, which have passed the tip of the giant branch and lie in the so-called 'clump'. As part of a major survey of the ultraviolet and X ray properties of a well-defined sample of evolved giant stars, DK UMa was observed with the Extreme Ultraviolet Explorer (EUVE) spacecraft in March 1997, for a total exposure time of 230 kiloseconds. A plot of the extracted short-wavelength (SW) spectrum of this star is shown, where it is compared with similar EUVE exposures for other yellow and red giant stars in the activity survey. In terms of the spectral lines of different ionization stages present in these spectra, the transition region and coronal temperature of DK UMa appears to be intermediate between those of 31 Com and P Ceti. Combining the relative strengths of the EUVE lines with Hubble Space Telescope (HST) data at near UV wavelengths and with ROSAT X-ray fluxes, the differential emission measure (DEM) distributions of these stars form a sequence in coronal temperature, which peaks at 10(exp 7.2) K for 31 Com, at 10(exp 6.8) K for B Ceti, and at intermediate temperatures for DK UMa - consistent with the evolutionary stages represented by the three stars. The integrated fluxes of the strongest emission lines found in the EUVE spectrum of DK UMa are listed, again compared with similar measurements for other giant stars that were observed in the course of other EUVE Guest Observer programs.

Simon, Theodore

1999-01-01

143

A emissão em 8mm e as bandas de Merrill-Sanford em estrelas carbonadas  

NASA Astrophysics Data System (ADS)

Estrelas carbonadas possuem bandas moleculares em absorção no visível e, no infravermelho (IR) as principais características espectrais se devem a emissão de grãos. Recentemente foi detectada a presença de bandas de SiC2 (Merrill-Sanford, MS) em emissão sendo atribuída à presença de um disco rico em poeira. Neste trabalho analisamos uma amostra de 14 estrelas carbonadas, observadas no telescópio de 1.52 m do ESO em 4 regiões espectrais diferentes, a fim de detectar as bandas de MS em emissão. Nossa amostra é composta de estrelas que apresentam além da emissão em 11.3 mm, outra em 8 mm. Esta última emissão, não usual nestes objetos, tem sido atribuída ou a moléculas de C2H2, ou a um composto sólido ainda indefinido. A detecção de emissões de MS e aquelas no IR, simultaneamente, revelaria um cenário mais complexo que o habitualmente esperado para os ventos destes objetos. No entanto como primeiro resultado, verificamos que as bandas de Merrill-Sanford encontram-se em absorção, não revelando nenhuma conexão com a emissão a 8 mm. Assim, temos duas hipóteses: (a) a emissão a 8 mm se deve à molécula C2H2 ou (b) essa emissão é resultado da emissão térmica de grãos. Testamos a segunda hipótese modelando a amostra com grãos não-homogêneos de SiC e quartzo, o qual emite em aproximadamente 8mm. Este grão seria produzido em uma fase evolutiva anterior a das carbonadas (estrelas S) e por terem uma estrutura cristalina são destruídos apenas na presença de campos de radiação ultravioleta muito intensos. Os modelos para os envoltórios utilizam o método de Monte Carlo para descrever o problema do transporte da radiação. As conclusões deste trabalho são: (1) as bandas de Merrill-Sanford se encontram em absorção, sugerindo um cenário usual para os ventos das estrelas da amostra; (2) neste cenário, a emissão em 8 mm seria resultado de grãos de quartzo com mantos de SiC, indicando que o quartzo poderia sobreviver a fase evolutiva S.

de Mello, A. B.; Lorenz-Martins, S.

2003-08-01

144

Comportamento de Pantala flavescens (Odonata, Anisoptera, Libellulidae) e perda do investimento reprodutivo em áreas antropizadas  

Microsoft Academic Search

RESUMO: Pantala flavescens é uma libélula exofítica, territorialista e migratória. Devido ao comportamento migratório, a ocorrência desta espécie em áreas não alagadas é comum. No entanto, a presença de P. flavescens em áreas de estacionamento de veículos e o registro de eventos de oviposição sobre as latarias de automóveis não é bem entendida. O presente trabalho apresenta dados comportamentais de

Antonia Figueira Van de Koken

2007-01-01

145

21 CFR 520.1870 - Praziquantel tablets.  

...ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520...order of a licensed veterinarian. (2) Cats —(i) Indications for use. For...Taenia taeniaeformis. (ii) Dosage. Cats 4 pounds and under, 11.5 mg; 5...

2014-04-01

146

21 CFR 520.1870 - Praziquantel tablets.  

Code of Federal Regulations, 2013 CFR

...ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520...order of a licensed veterinarian. (2) Cats —(i) Indications for use. For...Taenia taeniaeformis. (ii) Dosage . Cats 4 pounds and under, 11.5 mg; 5...

2013-04-01

147

21 CFR 520.1870 - Praziquantel tablets.  

Code of Federal Regulations, 2012 CFR

...ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520...order of a licensed veterinarian. (2) Cats —(i) Indications for use. For...Taenia taeniaeformis. (ii) Dosage . Cats 4 pounds and under, 11.5 mg; 5...

2012-04-01

148

21 CFR 520.1870 - Praziquantel tablets.  

Code of Federal Regulations, 2011 CFR

...ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520...order of a licensed veterinarian. (2) Cats —(i) Indications for use. For...Taenia taeniaeformis. (ii) Dosage . Cats 4 pounds and under, 11.5 mg; 5...

2011-04-01

149

21 CFR 522.1870 - Praziquantel.  

Code of Federal Regulations, 2013 CFR

...removal of canine cestodes Dipylidium caninum, Taenia pisiformis, and Echinococcus granulosus, and removal and control of canine cestode Echinococcus multilocularis . (iii) Limitations. Federal law restricts this drug to use...

2013-04-01

150

21 CFR 522.1870 - Praziquantel.  

...removal of canine cestodes Dipylidium caninum, Taenia pisiformis, and Echinococcus granulosus, and removal and control of canine cestode Echinococcus multilocularis. (iii) Limitations. Federal law restricts this drug to use...

2014-04-01

151

Analisando livros didáticos na perspectiva dos Estudos do Discurso: compartilhando reflexões e sugerindo uma agenda para a pesquisa  

Microsoft Academic Search

Resumo: Neste artigo, apÛs uma breve revisªo de pesquisas que tomam o livro didÆtico como objeto, delineamos os pressupostos teÛrico-metodolÛgicos de abordagens identificadas com os Estudos do Discurso e que tŒm fundamentado nossas investigaÁies sobre o livro didÆtico de ciŒncias. Em seguida, apresentamos nossas investigaÁies, que significam o livro didÆtico de ciŒncias em relaÁªo ‡s suas condiÁies sociais de produÁªo,

Isabel Martins

2006-01-01

152

A Rodaviva das Tecnologias Novas tecnologias do origem, em geral, a novos modelos de negcio que por sua vez  

E-print Network

A Roda­viva das Tecnologias Novas tecnologias dão origem, em geral, a novos modelos de negócio que palavras, velhas tecnologias reaparecem com uma nova roupagem como se submetidas a um processo de mundo. O uso dos browsers para utilizar esses servidores é nada mais do que uma nova roupagem para um

153

ISSN 0103-9741 Monografias em Cincia da Computao  

E-print Network

, jogos para telefones celulares podem ser sé- rios candidatos a se tornarem uma forma importante de entretenimento em um futuro próximo. Entretanto, a maioria dos jogos (para computadores, consoles e dispositivos tipo de entretenimento. Embora jogos para telefones celulares pu- dessem atender a muitos usuários com

Endler, Markus

154

A Morta de Oswald de Andrade: A Emergência de uma mímesis Paradoxal no Teatro Brasileiro  

E-print Network

Mimesis e Modernidade, Luiz Costa Lima retoma a história do conceito entre os gregos. A mimesis surge no pernsamento grego a partir do século V, com os pitagóricos, que a teorizaram como "conceito fundamental de sua filosofia da expressão dos estados... produção do sentido a partir de uma filosofia da diferença, ver Deleuze, Logique du Sens. 4. O par conceituai de Linda Hutcheon é análogo ao de Costa Lima. A autora define mimesis de produto como aquela em que "the reader is required to identify...

Vasconcelos Avelar, Idelber

1995-10-01

155

Structure and evolution of W UMa-type systems  

NASA Astrophysics Data System (ADS)

We summarize and discuss our recent works on the structure and evolution of low-mass W UMa-type contact binary stars. Three conclusions are given as followings: (1) The energy transfer is taken place in the radiative region of common envelope of W UMa systems; (2) The magnetic activity level of W UMa systems is weaker than that of non-contact binaries or rapid-rotating single stars; (3) The evolutionary outcome of W UMa systems might be the rapid-rotating single stars, and an average lifetime is derived to be about 7 Gyr for W UMa systems.

Li, Lifang; Zhang, Fenghui; Han, Zhanwen; Jiang, Dengkai; Jiang, Tianyu

2008-10-01

156

Análise das Atribuições Causais do Sucesso e do Insucesso na Competição, em Função do Nível Competitivo dos Futebolistas Portugueses Analysis of Causal Attributions of Success and Failure in Competitions Regarding Portuguese Soccer Players' Competition Level  

Microsoft Academic Search

Resumo Tendo como referência o modelo atribuicional da motivação e emoção de Weiner (1979), pretendeu-se avaliar as atribuições causais, em situações de sucesso e insucesso desportivo, em função da influência dos diferentes níveis competitivos dos futebolistas portugueses. Analisando uma amostra que integrou 125 futebolistas, que participaram em três níveis competitivos do futebol português (II Divisão; III Divisão; I Divisão Distrital),

Paulo Malico Sous; António Boleto Rosado; Túlia Maia Cabrita

157

A Roda-viva das Tecnologias Novas tecnologias do origem, em geral, a novos modelos de negcio que por sua vez  

E-print Network

A Roda-viva das Tecnologias Novas tecnologias dão origem, em geral, a novos modelos de negócio que palavras, velhas tecnologias reaparecem com uma nova roupagem como se submetidas a um processo de mundo. O uso dos browsers para utilizar esses servidores é nada mais do que uma nova roupagem para um

158

Theoritical research on the W UMa contact binary  

NASA Astrophysics Data System (ADS)

A review of the observational and theoretical study history for the W UMa-type contact binaries is presented in this paper. The observational characteristics and the theoretical results for this kind of stars are summarized. Finally, some of problems and possible solution for the theoretical models of the W UMa-type contact binaries are discussed.

Li, Li-Fang; Zhang, Feng-Hui

2004-03-01

159

A clínica pulsional de Wilhelm Reich: uma tentativa de atualização  

Microsoft Academic Search

Busca-se propor uma fundamentação da psicoterapia corporal de inspiração reichiana dentro do quadro de referência da pri meira teoria freudiana das pulsões. Tenta-se explicar os elementos próprios da abordagem reichiana a partir da idéia de uma dinâmica psíquica baseada no conflito entre pulsão e defesa. Também são discutidas, brevemente, algumas possibilidades de ampliação desse modelo a partir de propostas oriundas

Ricardo Amaral Rego

2003-01-01

160

Umas coisitas de grafos e uma introduc~ao informal `a complexidade computacional  

E-print Network

teoria dos grafos e comple- xidade computacional. Em 2 introduzem-se conceitos e propriedades elementares da teoria dos grafos, com ^enfase para a terminologia e metodologia decorrentes da teoria dos emparelhamentos. A teoria dos emparelhamentos ocupa um lugar de relevo na teoria dos grafos. ´E pois frequente os

Lisboa, Universidade Técnica de

161

Óleos essenciais no controle pós-colheita de Colletotrichum gloeosporioides em mamão  

Microsoft Academic Search

RESUMO: Os subprodutos de plantas medicinais têm sido estudados como uma alternativa para o controle de doenças de plantas visando amenizar e\\/ou reduzir o uso abusivo de agrotóxicos, principalmente em condições pós-colheita. Assim, este trabalho teve como objetivo avaliar, in vitro e in vivo, o controle de Colletotrichum gloeosporioides, agente causal da antracnose do mamão em pós-colheita, por óleos essenciais

162

Colquio em homenagem ao centenrio da morte de Henri Poincar Rio de Janeiro  

E-print Network

Colóquio em homenagem ao centenário da morte de Henri Poincaré Rio de Janeiro 27 a 30 de novembro Henri Poincaré (Université Nancy 2) Em 2012, ocorrerá o primeiro centenário da morte do matemático morte de Poincaré, além de ser uma merecida homenagem a um cientista-filósofo, cujas idéias ainda hoje

Solodov, Mikhail V.

163

Abordagem do tema hipertensão arterial e suas relações com o tabagismo e a obesidade como forma de avaliação da aquisição e socialização de conhecimentos em Feiras de Ciências  

Microsoft Academic Search

O presente trabalho apresenta a experiência vivenciada por um professor do Ensino Fundamental de Escola Pública do Paraná, na orientação de uma equipe de alunos de 8ª série, em 2008, visando o desenvolvimento de trabalhos em Feiras de Ciências. A temática da equipe enfoca a hipertensão arterial e seus fatores de risco, tabagismo e obesidade, no município de Floresta. Escolheu-se

Eduardo de Almeida Grenier; Celso Ivam Conegero

2008-01-01

164

Bactérias da família Enterobacteriaceae em Alphitobius diaperinus oriundos de granjas avícolas dos Estados do Rio Grande do Sul e Santa Catarina, Brasil  

Microsoft Academic Search

O cascudinho (Alphitobius diaperinus) é um inseto considerado como uma das maiores pragas da indústria avícola no Brasil e em diversos países no mundo. A presença dele nos aviários gera diversos transtornos, pois sua ingestão pelas aves, prejudica o ganho de peso e também podem albergar e disseminar entre as aves diversos patógenos. Coletaram-se cascudinhos em seis empresas avícolas dos

Stefanie Dickel Segabinazi; Maristela Lovato Flôres; Aléverson da Silva Barcelos; Gislaine Jacobsen; Rosângela Dariva Eltz

165

Ensino de gravitação clássica no nível médio: uma proposta de abordagem e resultados preliminares  

NASA Astrophysics Data System (ADS)

O ensino de gravitação clássica é comumente realizado de maneira formal e descontextualizado da experiência com a força-peso e da história do tema. Fustigados por anos de experiência de ensino no assunto, nem sempre com bons resultados, propomos uma abordagem ancorada nos eixos: a) contextualização histórica; e b) reconhecimento do peso como a força de atração gravitacional. O primeiro eixo integra o tema no desenvolvimento cultural do ser humano, praticando a interdisciplinaridade. O segundo eixo embasa construtivamente a abordagem, levando o aluno a realizar experiências e a vivenciar o reconhecimento de uma força universal. A abordagem foi construída através das etapas: 1) análise crítica do tema em livros didáticos; 2) elaboração de um curso para professores das várias disciplinas do ensino médio, identificando conexões para a prática da interdisciplinaridade; 3) elaboração de material didático; e 4) avaliação da eficácia da abordagem. No trabalho discutimos em detalhe as quatro etapas. Como resultados, adiantamos que: tabulamos a abordagem de gravitação nos livros didáticos, ainda muito tradicional e carecedora de atividades criativas que poderiam melhor explorar esse assunto; mapeamos, junto aos professores, padrões de conceitos espontâneos e erros associados ao tema; e, no curso, adaptamos e testamos a eficiência de materiais instrucionais existentes e criamos outros novos (e.g., para trabalhar excentricidades das órbitas planetárias), além disto elaboramos roteiros e figuras para tratamentos qualitativo e quantitativo da lei da gravitação universal. As avaliações feitas pelos professores foram muito animadoras. O espaço da presente reunião será aproveitado para socializar a proposta e os resultados obtidos e para submeter o projeto à análise crítica. (PPGECNM/UFRN; PRONEX/FINEP; NUPA/USP; Temáticos/FAPESP)

Medeiros, G. C. M.; Jafelice, L. C.

2003-08-01

166

Uma possível interpretação da referência musical em De Umbris de Oiliam Lanna  

Microsoft Academic Search

The present study is an inquiry, based on the semiotic theory of Charles Sanders Peirce (1839-1914), about the possible meanings that can be extracted from the piece De Umbris, for two bassoons and piano, composed in 1992 by Oiliam Lanna. The horizon of this science is very broad, touching different areas of human knowledge (psychoanalysis, literature, music, etc.). The musical

Cecília Nazaré de Lima

167

COMUNICAÇÃO DIVERSIDADE GENÉTICA EM CONÍFERAS: UMA APROXIMAÇÃO UTILIZANDO-SE ACÍCULAS1  

Microsoft Academic Search

In this investigation, earlier results from a genetical diversity analysis in species of Pinus using DNA-RAPD markers were reported. Pinus patula Schi- ede e Deppe needles and of the Mountain Pine Ridge and San Rafael provenance of the Tecun Umán Pinus, were employed for DNA extraction. The extraction protocol was defined and the amplification reactions optimized. The genetical similarities and

RENATA SILVA-MANN; LISETE CHAMMA DAVIDE; BOSCO DOS SANTOS

168

Em busca de uma teoria da localização das agências bancárias: algumas evidências do caso brasileiro  

Microsoft Academic Search

The aim of this piece is to identify the variables that explain the locational decision of a retail bank. The paper’s motivation is the acknowledgment of the necessity of to retake the discussion about the role of money, financial system and monetary policy on the development of regions, due both to the observation of empirical data that shows a huge

João Sicsú; Marco Crocco

2003-01-01

169

Estudos de separação enantiosseletiva para uma série de sulfóxidos quirais em colunas poliméricas.  

E-print Network

??Este trabalho descreve a investigação do poder de enantiorresolução de novas fases estacionária quirais (CSP) de polímero sintético preparadas a partir dos monômeros poli(trans-1,2-ciclohexanediil-bis acrilamida… (more)

Tiago de Campos Lourenço

2010-01-01

170

UMA ABORDAGEM ALGBRICA PARA WORKFLOWS CIENTFICOS COM DADOS EM LARGA ESCALA  

E-print Network

.Sc. ________________________________________________ Prof. Jano Moreira de Souza, Ph.D. ________________________________________________ Profa . Claudia algoritmos; � Claudia Bauzer de Medeiros, Jano Moreira de Souza e Marco Antônio Casanova, por terem aceitado Júnior, Fellipe Duarte, João Quadros, Jorge Abreu, Myrna Amorim, Rafael Castaneda, Renato Mauro, pelo

Paris-Sud XI, Université de

171

JOGO DE LUZES: SOMBRAS E CORES DE UMA PESQUISA EM EDUCAÇÃO AMBIENTAL 1  

Microsoft Academic Search

Considering the four basic components of distance education - specialists, students, technological mediators and pedagogical mediators, this text aims to promote an epistemological and methodological debate in environmental education research, through sociopoetics and phenomenological dimensions. Setting sights on limits and potential of social theories, considers three major struggles on environmental education and discusses some ways to rise above the difficulties.

Michèle Sato; Jacques Zanidê Gauthier

172

A COMPLEXIDADE EM GEOGRAFIA  

Microsoft Academic Search

Muitos de nós, nas suas infâncias, sucumbimos à curiosidade, achando que valia o risco de apanharmos umas palmadas correctivas, e desmontámos o brinquedo novo que tínhamos acabado de receber, só para tentar perceber como aquelas peças se encaixavam umas-nas-outras e de forma articulada permitiam ao brinquedo funcionar? Pois é, apesar de haver alguns menos confessos, a verdade é que passados

JORGE ROCHA; PAULO MORGADO SOUSA

173

População estelar nuclear e extranuclear em galáxias Seyfert 2  

NASA Astrophysics Data System (ADS)

A luz das estrelas foi, historicamente, vista por observadores de AGNs como uma poluição inconveniente. Conseqüentemente, a informação contida nas características estelares foi, durante muito tempo, largamente omitida. Nos primeiros estudos, o método empregado para remover esta contaminação estelar foi representá-la por um template de galáxia elíptica e subtraí-la do espectro observado, restando o puro AGN como um resíduo. Hoje sabemos que não é tão simples representar essa população. Vários estudos têm mostrado a presença de formação estelar recente próxima a região nuclear de galáxias Seyfert. Neste trabalho foi revisada a abordagem tradicional, tendo-se focalizado a análise na luz estelar. Espectros óticos de fenda longa, com alta razão sinal/ruído, foram usados para estudar a variação radial das larguras equivalentes de linhas de absorção e cores do contínuo. Utilizando o método de síntese espectral de populações estelares, foram estimadas as contribuições de populações estelares de diferentes idades (e de um contínuo tipo lei de potência) para a luz integrada das galáxias, em 4020A. As principais conclusões deste trabalho são: na região nuclear, mais da metade das galáxias Seyfert 2 da amostra (57%) apresenta contribuições das populações com 100 milhões de anos ou mais jovens superior a 20% do fluxo em 4020A, enquanto que em cerca de 40% delas a componente de 3 milhões de anos (e/ou luz que provem de um núcleo ativo) tem contribuição significativa (maior do que 10%). Estas contribuições em geral decrescem quando se vai para regiões mais distantes do centro das galáxias, respectivamente 53% e 30% a 1kpc, 40% e 15% a 3kpc do centro das galáxias. Estes resultados foram comparados com aqueles obtidos para uma amostra de galáxias não ativas de mesmo tipo de Hubble das Seyfert. Em uma análise inicial nota-se que em geral as galáxias Seyfert apresentam contribuições das populações de 100 milhões de anos maiores do que aquelas encontradas nas galáxias não ativas, sugerindo uma ligação entre a formação estelar e a atividade em galáxias.

Raimann, D. I.; Storchi-Bergmann, T.; Cid Fernandes, R., Jr.; Delgado, R. M. G.; Schmitt, H.; Heckman, T.; Leitherer, C.

2003-08-01

174

Conhecimento e Dinamismo Psíquico em Dois Sermões no Brasil Colonial1  

Microsoft Academic Search

RESUMO - O trabalho aborda as relações entre conhecimento e dinamismo psíquico em dois sermões pregados no Brasil por Eusebio de Mattos, no século XVII e por Bento da Trindade, no século XVIII. Uma concepção de conhecimento afetivo implicando as atividades das potências anímicas defi ne o êxtase dos místicos como ato do entendimento aplicado ao objeto supremo, Deus. Esta

Marina Massimi

175

O Feminino na Mídia: novos argumentos em busca de novos sentidos 1  

Microsoft Academic Search

Este artigo se propõe a discutir sob o ponto da Aná lise Crítica de Discurso (ACD) a inserção de novos discursos nas peças de publicidad e, direcionadas ao público feminino. Para elaborar uma breve análise toma-se como objeto recortes da campanha da Linha Natura de cosméticos. Os pressupostos teóricos estã o em Baktin (2004), no que diz respeito à representação

Eliane Penha Mergulhão Dias

176

IDENTIFICAC ~AO E RASTREAMENTO EM TEMPO REAL DE M ULTIPLOS AGENTES AUT ^ONOMOS  

E-print Network

- treamento em tempo real de objetos durante o jogo. Diversos experimentos reais s~ao realizados para^amera instalada a uma altura m´inima de 3 metros acima do campo ´e utilizada para capturar imagens do jogo, que s´aticas de jogos. As ac¸~oes no dom´inio s~ao r

Zhang, Richard "Hao"

177

Um Framework para Proviso de QoS em Redes Mveis Sem Fio1  

E-print Network

Um Framework para Provisão de QoS em Redes Móveis Sem Fio1 Luciana dos Santos Lima, Antônio Tadeu A provisão de QoS em redes móveis sem fio integrando soluções isoladas encontradas na literatura. Esses descrita através de um cenário simulado em que serviços integrados são oferecidos sobre uma rede IP Móvel

Colcher, Sérgio

178

UFF/PROGEPE/CASQ/DPVS Diviso de Promoo e Vigilncia em Sade-DPVS  

E-print Network

considerado uma das principais causas de morte evitável. No mundo, cerca de 1,3 bilhões de pessoas são considerado como a terceira maior causa de morte evitável aumentando a morbidade em crianças por doenças respiratórias e em cinco vezes o risco de morte súbita em bebês. A atual Portaria Nº 3 de 25 de março de 2013 da

Souza, Max O.

179

EM International. Volume 1  

SciTech Connect

It is the intent of EM International to describe the Office of Environmental Restoration and Waste Management`s (EM`s) various roles and responsibilities within the international community. Cooperative agreements and programs, descriptions of projects and technologies, and synopses of visits to international sites are all highlighted in this semiannual journal. Focus on EM programs in this issue is on international collaboration in vitrification projects. Technology highlights covers: in situ sealing for contaminated sites; and remote sensors for toxic pollutants. Section on profiles of countries includes: Arctic contamination by the former Soviet Union, and EM activities with Germany--cooperative arrangements.

Not Available

1993-07-01

180

Compilação de dados atômicos e moleculares do UV ao IV próximo para uso em síntese espectral  

NASA Astrophysics Data System (ADS)

Espectros sintéticos são utéis em uma grande variedade de aplicações, desde análise de abundâncias em espectros estelares de alta resolução ao estudo de populações estelares em espectros integrados. A confiabilidade de um espectro sintético depende do modelo de atmosfera adotado, do código de formação de linhas e da qualidade dos dados atômicos e moleculares que são determinantes no cálculo das opacidades da fotosfera. O nosso grupo no departamento de Astronomia no IAG tem utilizado espectros sintéticos há mais de 15 anos, em aplicações voltadas principalmente para a análise de abundâncias de estrelas G, K e M e populações estelares velhas. Ao longo desse tempo, as listas de linhas vieram sendo construídas e atualizadas continuamente, e alguns acréscimos recentes podem ser citados: Castilho (1999, átomos e moléculas no UV), Schiavon (1998, bandas moleculares de TiO) e Melendez (2001, átomos e moléculas no IV próximo). Com o intuito de calcular uma grade de espectros do UV ao IV próximo para uso no estudo de populações estelares velhas, se fazia necessário compilar e homogeneizar as diversas listas em apenas uma lista atômica e uma molecular. Nesse processo, a nova lista compilada foi correlacionada com outras bases de dados (NIST, Kurucz Database, O' Brian et al. 1991) para atualização dos parâmetros que caracterizam a transição atômica (comprimento de onda, log gf e potencial de excitação). Adicionalmente as constantes de interação C6 foram calculadas segundo a teoria de Anstee & O'Mara (1995) e artigos posteriores. As bandas moleculares de CH e CN foram recalculadas com o programa LIFBASE (Luque & Crosley 1999). Nesse poster estão detalhados os procedimentos citados acima, as comparações entre espectros calculados com as novas listas e espectros observados em alta resolução do Sol e de Arcturus, e uma análise do impacto decorrente da utilização de diferentes modelos de atmosfera no espectro sintético. Ao final, temos uma lista de linhas atômicas com mais de 24.000 linhas e uma lista molecular com as moléculas CN, CH, OH, NH, MgH, C2, TiO Gama, CO, FeH, adequadas ao estudo de estrelas G, K e M e populações estelares velhas.

Coelho, P.; Barbuy, B.; Melendez, J.; Allen, D. M.; Castilho, B.

2003-08-01

181

APLICAO DE AGENTES MVEIS EM REDES DE SENSORES SEM FIO PARA LOCALIZAO E SEGUIMENTO DE OBJETOS ALVOS MVEIS  

E-print Network

APLICA��O DE AGENTES M�VEIS EM REDES DE SENSORES SEM FIO PARA LOCALIZA��O E SEGUIMENTO DE OBJETOS sistema embarcado baseada em uma aplicação de localização e seguimento de objeto alvo utilizando redes de sensores sem fio (RSSF). Sendo os nós da rede fixos, realiza-se o seguimento do alvo utilizando agentes

Wagner, Flávio Rech

182

Large-Amplitude Modulations of the Cataclysmic Star ER UMa  

NASA Astrophysics Data System (ADS)

We present our BR observations of the cataclysmic star ER UMa covering three consecutive light cycles at quiescence. Their light curves are asymmetric with steeper decreasing branch. While the large light amplitudes of the first two cycles may be expected for the quiescent state, the 0.9^{m} amplitude of the third cycle is unusual big. The period of the observed light modulations in 2008 is shorter than the orbital one. Thus our observations leaded to a discovery of large-amplitude negative superhumps at quiescent state of ER UMa.

Kjurkchieva, D.; Marchev, D.

2010-09-01

183

BZ UMa and Var Her 04: Orphan TOADS  

NASA Astrophysics Data System (ADS)

Both BZ UMa and Var Her 04 are cataclysmic variable stars without a home. Neither fit easily into current classification systems so may extend the population distribution of two unique CV types: UGWZ dwarf novae and intermediate polars. New outburst photometry and archival X-Ray data shed some new light on BZ UMa's high energy state and new spectral and IR observations from Spitzer of dust around the newly discovered cataclysmic variable Var Her 04 may help find it a home as well.

Price, A.; Howell, S.

2005-05-01

184

The Spatial Distribution of W UMa-Type Stars  

NASA Astrophysics Data System (ADS)

The aim of this project is to study the spatial distribution of contact binaries and to compare the sample from the project of study the W UMa-type stars, with existing databases such as Hipparcos, GCVS or ASAS (ESA, 1997; GCVS, 2005; Pojmanski, 2002).

Ogloza, Waldemar; Zakrzewski, Bartlomiej

2006-08-01

185

Thermal Image of Halema'uma'u Vent  

USGS Multimedia Gallery

This thermal image shows the view of the Halema`uma`u vent from today's overflight. The kidney-shaped lava pond, about 90 meters long, is deep within the vent cavity. The mostly-crusted lava migrates from the north (right in this photo), where it upwells from depth, to the south, where is si...

2010-07-19

186

Memory Systems for Cognitive Agents Uma Ramamurthy1  

E-print Network

Memory Systems for Cognitive Agents Uma Ramamurthy1 and Stan Franklin2 Abstract. The several different memory systems in human beings play crucial roles in facilitating human cognition. To build and cognitive science. In this paper we describe the various memory systems in the LIDA Architecture, which

Ramamurthy, Uma

187

Halema?uma?u Crater and Rock Fall Plume  

USGS Multimedia Gallery

This image of a dusty plume produced by rocks collapsing from the wall of the eruptive vent within K?lauea Volcano’s Halema‘uma‘u Crater was captured by a USGS time-lapse camera on December 21, 2011.  Vigorous spattering on the lava lake deep within the vent created the o...

188

Estudo de soluções locais e cosmológicas em teorias do tipo tensor-escalar  

NASA Astrophysics Data System (ADS)

Teorias do tipo tensor-escalar são a mais simples extensão possí vel da Relatividade Geral. Nessas teorias, cujo modelo padrão é a teoria de Brans-Dicke, a curvatura do espaço-tempo, descrita por componentes tensoriais, aparece acoplada a um campo escalar que, de certo modo, representa uma variação na constante de acoplamento da gravitação. Tais teorias apresentam soluções locais e cosmológicas que, em determinados limites, recaem nas apresentadas pela Relatividade Geral, mas que em outros limites trazem novidades, tais como conseqüências observacionais da evolução de flutuações primordiais distintas daquelas previstas pela Relatividade Geral (ver, por ex., Nagata et al., PRD 66, p. 103510 (2002)). Graças a esta possibilidade de trazer à luz novidades em relação à gravitação, teorias do tipo tensor-escalar podem ser vistas como um interessante campo alternativo de pesquisas para soluções dos problemas de massa faltante (ou escura) e/ou energia escura. Seguindo tal linha, este trabalho, ainda em sua fase inicial, apresenta soluções gerais de teorias do tipo tensor-escalar para diversas situações, verificando-se em que consiste a divergência dessas soluções dos casos tradicionais possí veis na Relatividade Geral. Como exemplos das soluções aqui apresentadas pode-se destacar uma expressão geral para diferentes soluções cosmológicas englobando diferentes tipos de matéria (representados por diferentes equações de estado), e a expressão para uma solução local representando um buraco negro com rotação, similar à solução de Kerr da Relatividade Geral. Por fim, é importante ressaltar que, embora aqui apresentem-se poucos resultados novos, na literatura sobre o assunto a maior parte das soluções apresentadas limita-se a uns poucos casos especí ficos, tal como soluções cosmológicas apenas com curvatura nula, e que mesmo as soluções disponí veis são, em geral, pouco divulgadas e, portanto, pouco conhecidas, e é tal situação que este trabalho busca, em parte, reverter.

Silva E Costa, S.

2003-08-01

189

Prevalência e intensidade da infecção por parasitas intestinais em crianças na idade escolar na Cidade de Salvador (Bahia, Brasil) Prevalence and intensity of infection by intestinal parasites in school-aged children in the City of Salvador (Bahia State, Brazil)  

Microsoft Academic Search

1 Resumo Como parte de um estudo para avaliar as relações entre mudanças ambientais e ocorrência de infecções, estudou-se a prevalência e intensidade de parasitas intestinais em uma amostra de crianças em idade escolar, residentes em Salvador. A prevalência de infectados por pelo menos um protozoário\\/helminto foi 66,1%. A prevalência da infecção por helmintos, se eleva com o aumento da

Maurício L. Barreto; Agostino Strina; João Augusto; S. Faria; Aline A. Nobre; Sandra R. Jesus

190

Relações solo-geoambiente em áreas de ocorrências de Ipucas na planície do Médio Araguaia - Estado de Tocantins  

Microsoft Academic Search

RESUMO - Dentre as paisagens do médio rio Araguaia, destacam-se as extensas planícies e depressões sazonalmente alagadas. Nelas se inserem formações florestais higrófilas denominadas Ipucas, como enclaves peculiares pela sua fitossociologia e ambiente pedogeomorfológico. Esses fragmentos florestais naturais ocorrem na planície fluvial, em região de ecótono entre o Cerrado e a Floresta Amazônica. Neste estudo, foi selecionada uma área de

Alan Kardec Elias Martins; Carlos Ernesto G. R. Schaefer; Elias Silva; Vicente Paulo Soares; Guilherme Resende Corrêa; Bruno Araújo Furtado de Mendonça

2006-01-01

191

Um estudo do uso de SGBDs relacionais em arquiteturas de jogos multi-jogador Lauro Eduardo Kozovits  

E-print Network

Um estudo do uso de SGBDs relacionais em arquiteturas de jogos multi-jogador Lauro Eduardo Kozovits balance, scalability. Resumo: A tecnologia de jogos com número elevado de jogadores é tanto um negócio uma especialização dentro da área de ambientes virtuais distribuídos, jogos multi-jogador possuem

Endler, Markus

192

Exosat and IUE observations of SW UMa during superoutburst  

NASA Technical Reports Server (NTRS)

IUE and Exosat observations obtained during the March 1986 superoutburst of the SU UMa type dwarf nova SW UMa are presented. The observations show the presence of a hot, extensive, optically thick disk. The UV fluxes show an increase of 1000 over the quiescent values, implying a large increase in mass accretion rate. The Exosat obserations show an increase in the soft X-ray count rate by a factor of 44 over quiescence, while the medium-energy flux remains undetected. The most surprising result is that the softness ratio in superoutburst is similar to the quiescent value of 0.3. No variation at the orbital or spin periods or at the superhump period are evident in the superoutburst X-ray data. A transient variation is observed at 5.1 minutes similar to that observed in the optical a few days after the X-ray observations.

Szkody, Paula; Osborne, Julian; Hassall, B. J. M.

1988-01-01

193

The SU UMa Nature of the Dwarf Nova, DM Lyrae  

NASA Astrophysics Data System (ADS)

We carried out time-resolved V-band photometry of DM Lyr during long outbursts in 1996 July and in 1996 February-March at Ouda Station, Kyoto University, and at Osaka Kyoiku University. Since superhumps were clearly detected in the light curves, DM Lyr was first identified as being an SU UMa-type dwarf nova. The superhump period is 0.0673(2)d, and the superhump excess is 2.8(3)&. The duration of the superoutburst, the outburst amplitude, the decline rate in the plateau phase, and the superhump excess were typical values for a usual SU UMa star.According to visual and CCD observations reported to VSNET, this star has experienced a dramatic change of the outburst pattern from a superoutburst phase to a normal outburst phase. There may exist mechanisms to decrease the number of normal outbursts between two successive superoutbursts and to elongate the recurrence cycle of the superoutburst.

Nogami, Daisake; Baba, Hajime; Matsumoto, Katsura; Kato, Taichi

2003-04-01

194

IX Draconis, ER UMa-type dwarf nova  

NASA Astrophysics Data System (ADS)

We present results of our world-wide observing campaign which was dedicated to one of the most active dwarf novae, IX Draconis. We investigated photometric behaviour of the system to derive its basic parameters. This study is important in the context of our understanding of the accretion process of IX Draconis, as well as other active cataclysmic variables, especially those from the still poorly studied type of ER UMa stars.

Otulakowska-Hypka, M.; Olech, A.; de Miguel, E.; Rutkowski, A.; Koff, R.; Bakowska, K.

2013-02-01

195

CC Sculptoris: Eclipsing SU UMa-type intermediate polar  

NASA Astrophysics Data System (ADS)

We observed the 2014 superoutburst of the SU UMa-type intermediate polar CC Scl. We detected superhumps with a mean period of 0.05998(2) d during the superoutburst plateau and during three nights after the fading. During the post-superoutburst stage after three nights, a stable superhump period of 0.059523(6) d was detected. We found that this object is an eclipsing system with an orbital period of 0.058567233(8) d. By assuming that the disk radius in the post-superoutburst phase is similar to those in other SU UMa-type dwarf novae, we obtained a mass ratio of q = 0.072(3) from the dynamical precession rate of the accretion disk. The eclipse profile during outbursts can be modeled by an inclination of 80.6° ± 0.5°. The 2014 superoutburst was preceded by a precursor outburst and the overall appearance of the outburst was similar to superoutbursts in ordinary SU UMa-type dwarf novae. We showed that the standard thermal-tidal instability model can explain the outburst behavior in this system and suggest that inner truncation of the disk by magnetism of the white dwarf does not strongly affect the behavior in the outer part of the disk.

Kato, Taichi; Hambsch, Franz-Josef; Oksanen, Arto; Starr, Peter; Henden, Arne

2014-12-01

196

A Dynamical Analysis of the 47 UMa Planetary System  

E-print Network

The mass and period ratios of the two planets orbiting 47 UMa suggest a possible kinship to the Jupiter-Saturn pair in our solar system. We explore the current dynamical state of the 47 UMa system with numerical integrations, and compare the results with analytic secular theory. We find that the planets in the system are likely participating in a secular resonance in which the difference in the longitudes of pericenter librates around zero. Alternately, it is possible that the system is participating in the 7:3 mean motion resonance. We show that stability considerations restrict the mutual inclination between the two planets to 40 degrees or less, and that this result is relatively insensitive to the total mass of the two planets. We present hydrodynamical simulations which measure the torques exerted on the planets by a hypothesized external protoplanetary disk. We show that planetary migration in response to torques from the disk may have led to capture of the system into a 7:3 mean-motion resonance, although it is unclear how the eccentricities of the planets would have been damped after capture occured. We show that Earth-mass planets can survive for long periods in some regions of the habitable zone of the nominal co-planar system. A set of planetary accretion calculations, however, shows that it is unlikely that large terrestrial planets can form in the 47 UMa habitable zone.

Gregory Laughlin; John Chambers; Debra Fischer

2002-05-29

197

Environmental Media Services (EMS)  

NSDL National Science Digital Library

Environmental Media Services (EMS) is a nonprofit communications clearinghouse committed to the expansion of media coverage on critical environmental and public health issues. True to their mission, EMS staff "build relationships with top scientists, physicians, and other experts to bring journalists the latest and most credible information." EMS's modest homepage is free of clutter but full of content. While several sections are under construction and updates (currently) appear irregular, a series of available articles provides useful summaries of important environmental news issues over the past six months. Current articles include "The impacts of global warming on the oceans" and "Cool companies," among others.

198

Brecht e Cordel: Distanciamento e Protesto em Se Correr o Bicho Pega  

E-print Network

brasileño," Mundo Nuevo, Num. 30 (diciembre 1968), 80. 3. Maria Helena Kiihner, "Reflexões sobre um teatro em tempo de síntese," Revista Civiliza ção Brasileira, Num. 4 (junho 1968), 37. (Caderno especial, No. 2) 4. Oduvaldo Vianna Filho e Ferreira... Grupo Opinião que até então apresentara seleção de autores nacionais e estrangeiros acompanhadas de música,2 como Liberdade, Liberdade, e elaboraram uma peça de reação anti burguesa dentro da realidade brasileira. Ao mesmo tempo que a obra é um...

Ishmael-Bissett, Judith

1977-10-01

199

Novas estratgias comunicativas como fator de qualidade na interao de surdos em um sistema organizacional  

E-print Network

122 Novas estratégias comunicativas como fator de qualidade na interação de surdos em um sistema formulário web e verificar se o uso de novas estratégias comunicativas melhora a interação dos surdos. Foram (MAC), uma com a interface original do sistema, e outra com o uso de novas estratégias comunicativas

Barbosa, Alberto

200

21 CFR 520.1198 - Ivermectin and praziquantel paste.  

Code of Federal Regulations, 2010 CFR

...treatment and control of: (i) Tapeworms—Anoplocephala perfoliata ; Large strongyles (adults)—Strongylus...microfilariae, Onchocerca sp. (ii) Tapeworms—Anoplocephala perfoliata ; Large Strongyles...

2010-04-01

201

21 CFR 520.1453 - Moxidectin and praziquantel gel.  

Code of Federal Regulations, 2010 CFR

...Gasterophilus intestinalis (2nd and 3rd instars) and G . nasalis (3rd instars); and tapeworms: Anoplocephala perfoliata (adults). One dose also suppresses strongyle egg production for 84 days. (3) Limitations ....

2010-04-01

202

21 CFR 520.1453 - Moxidectin and praziquantel gel.  

Code of Federal Regulations, 2012 CFR

...capitatus ; and Petrovinema poculatus ; small strongyles: undifferentiated lumenal larvae; encysted cyathostomes (late L3 and L4 mucosal cyathostome larvae); ascarids: Parascaris equorum (adults and L4 larval stages); pinworms:...

2012-04-01

203

21 CFR 520.1453 - Moxidectin and praziquantel gel.  

Code of Federal Regulations, 2013 CFR

...capitatus ; and Petrovinema poculatus ; small strongyles: undifferentiated lumenal larvae; encysted cyathostomes (late L3 and L4 mucosal cyathostome larvae); ascarids: Parascaris equorum (adults and L4 larval stages); pinworms:...

2013-04-01

204

21 CFR 520.1198 - Ivermectin and praziquantel paste.  

Code of Federal Regulations, 2011 CFR

...adults)—Trichostrongylus axei ; Large-mouth Stomach Worms (adults)—Habronema muscae ; Bots (oral and gastric stages...adults)—Trichostrongylus axei ; Large-mouth Stomach Worms (adults)—Habronema muscae ; Bots (oral and gastric...

2011-04-01

205

21 CFR 520.1453 - Moxidectin and praziquantel gel.  

...pinworms: Oxyuris equi (adults and L4 larval stages); hairworms: Trichostrongylus axei (adults); large-mouth stomach worms: Habronema muscae (adults); horse stomach bots: Gasterophilus intestinalis (2nd and 3rd instars) and G....

2014-04-01

206

21 CFR 520.1198 - Ivermectin and praziquantel paste.  

Code of Federal Regulations, 2012 CFR

...adults)—Trichostrongylus axei ; Large-mouth Stomach Worms (adults)—Habronema muscae ; Bots (oral and gastric stages...adults)—Trichostrongylus axei ; Large-mouth Stomach Worms (adults)—Habronema muscae ; Bots (oral and gastric...

2012-04-01

207

21 CFR 520.1198 - Ivermectin and praziquantel paste.  

Code of Federal Regulations, 2013 CFR

...adults)—Trichostrongylus axei ; Large-mouth Stomach Worms (adults)—Habronema muscae ; Bots (oral and gastric stages...adults)—Trichostrongylus axei ; Large-mouth Stomach Worms (adults)—Habronema muscae ; Bots (oral and gastric...

2013-04-01

208

21 CFR 520.1198 - Ivermectin and praziquantel paste.  

...adults)—Trichostrongylus axei ; Large-mouth Stomach Worms (adults)—Habronema muscae ; Bots (oral and gastric stages...adults)—Trichostrongylus axei ; Large-mouth Stomach Worms (adults)—Habronema muscae ; Bots (oral and gastric...

2014-04-01

209

21 CFR 520.1453 - Moxidectin and praziquantel gel.  

Code of Federal Regulations, 2011 CFR

...pinworms: Oxyuris equi (adults and L4 larval stages); hairworms: Trichostrongylus axei (adults); large-mouth stomach worms: Habronema muscae (adults); horse stomach bots: Gasterophilus intestinalis (2nd and 3rd instars) and G ....

2011-04-01

210

21 CFR 520.1200 - Ivermectin, fenbendazole, and praziquantel tablets.  

Code of Federal Regulations, 2010 CFR

...Trichuris vulpis (whipworm), and Dipylidium caninum (tapeworm), and for the prevention of heartworm disease caused by Dirofilaria immitis in adult dogs. (3) Limitations . Federal law restricts this drug to use by or on the order of a...

2010-04-01

211

21 CFR 520.1199 - Ivermectin, pyrantel, and praziquantel tablets.  

Code of Federal Regulations, 2010 CFR

... (2) Indications for use . Prevents canine heartworm disease by eliminating the tissue stage of heartworm larvae (Dirofilaria immitis ) for 1 month (30 days) after infection and for the treatment and control of roundworm (Toxocara canis,...

2010-04-01

212

21 CFR 522.1870 - Praziquantel injectable solution.  

Code of Federal Regulations, 2012 CFR

...removal of canine cestodes Dipylidium caninum, Taenia pisiformis, and Echinococcus granulosus, and removal and control of canine cestode Echinococcus multilocularis . (iii) Limitations. For subcutaneous or intramuscular...

2012-04-01

213

21 CFR 522.1870 - Praziquantel injectable solution.  

Code of Federal Regulations, 2011 CFR

...removal of canine cestodes Dipylidium caninum, Taenia pisiformis, and Echinococcus granulosus, and removal and control of canine cestode Echinococcus multilocularis . (iii) Limitations. For subcutaneous or intramuscular...

2011-04-01

214

21 CFR 520.1199 - Ivermectin, pyrantel, and praziquantel tablets.  

Code of Federal Regulations, 2011 CFR

...heartworm larvae (Dirofilaria immitis ) for 1 month (30 days) after infection and for the treatment and control of roundworm (Toxocara canis, Toxascaris leonina ), hookworm (Ancylostoma caninum, Uncinaria stenocephala, Ancylostoma braziliense )...

2011-04-01

215

21 CFR 520.903d - Febantel-praziquantel paste.  

...stenocephala ), whipworms (Trichuris vulpis ), ascarids (Toxocara canis and Toxascaris leonina ), and tapeworms (Dipylidium...removal of hookworms (Ancylostoma tubaeforme ), ascarids (Toxocara cati ) and tapeworms (Dipylidium caninum and Taenia...

2014-04-01

216

21 CFR 520.1199 - Ivermectin, pyrantel, and praziquantel tablets.  

Code of Federal Regulations, 2012 CFR

...heartworm larvae (Dirofilaria immitis ) for 1 month (30 days) after infection and for the treatment and control of roundworm (Toxocara canis, Toxascaris leonina ), hookworm (Ancylostoma caninum, Uncinaria stenocephala, Ancylostoma braziliense )...

2012-04-01

217

21 CFR 520.1871 - Praziquantel and pyrantel.  

...hookworms (Ancylostoma tubaeforme ), and large roundworms (Toxocara cati ) in cats and kittens. (iii) Limitations. ...Indications for use. For the treatment and control of roundworms (Toxocara canis and Toxascaris leonina ), hookworms...

2014-04-01

218

21 CFR 520.1445 - Milbemycin oxime and praziquantel.  

...For the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment and control of adult roundworm (Toxocara canis, Toxascaris leonina ), adult hookworm (Ancylostoma caninum ), adult whipworm (Trichuris vulpis ), and...

2014-04-01

219

21 CFR 520.903d - Febantel-praziquantel paste.  

Code of Federal Regulations, 2011 CFR

...stenocephala ), whipworms (Trichuris vulpis ), ascarids (Toxocara canis and Toxascaris leonina ), and tapeworms (Dipylidium...removal of hookworms (Ancylostoma tubaeforme ), ascarids (Toxocara cati ) and tapeworms (Dipylidium caninum and Taenia...

2011-04-01

220

21 CFR 520.1871 - Praziquantel and pyrantel.  

Code of Federal Regulations, 2013 CFR

...hookworms (Ancylostoma tubaeforme ), and large roundworms (Toxocara cati ) in cats and kittens. (iii) Limitations ...Indications for use . For the treatment and control of roundworms (Toxocara canis and Toxascaris leonina ), hookworms...

2013-04-01

221

21 CFR 520.1445 - Milbemycin oxime and praziquantel.  

Code of Federal Regulations, 2013 CFR

...For the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment and control of adult roundworm (Toxocara canis, Toxascaris leonina ), adult hookworm (Ancylostoma caninum ), adult whipworm (Trichuris vulpis ), and...

2013-04-01

222

21 CFR 520.1199 - Ivermectin, pyrantel, and praziquantel tablets.  

Code of Federal Regulations, 2013 CFR

...heartworm larvae (Dirofilaria immitis ) for 1 month (30 days) after infection and for the treatment and control of roundworm (Toxocara canis, Toxascaris leonina ), hookworm (Ancylostoma caninum, Uncinaria stenocephala, Ancylostoma braziliense )...

2013-04-01

223

21 CFR 520.903d - Febantel-praziquantel paste.  

Code of Federal Regulations, 2012 CFR

...stenocephala ), whipworms (Trichuris vulpis ), ascarids (Toxocara canis and Toxascaris leonina ), and tapeworms (Dipylidium...removal of hookworms (Ancylostoma tubaeforme ), ascarids (Toxocara cati ) and tapeworms (Dipylidium caninum and Taenia...

2012-04-01

224

21 CFR 520.1871 - Praziquantel and pyrantel.  

Code of Federal Regulations, 2011 CFR

...hookworms (Ancylostoma tubaeforme ), and large roundworms (Toxocara cati ) in cats and kittens. (iii) Limitations ...Indications for use . For the treatment and control of roundworms (Toxocara canis and Toxascaris leonina ), hookworms...

2011-04-01

225

21 CFR 520.1871 - Praziquantel and pyrantel.  

Code of Federal Regulations, 2012 CFR

...hookworms (Ancylostoma tubaeforme ), and large roundworms (Toxocara cati ) in cats and kittens. (iii) Limitations ...Indications for use . For the treatment and control of roundworms (Toxocara canis and Toxascaris leonina ), hookworms...

2012-04-01

226

21 CFR 520.903d - Febantel-praziquantel paste.  

Code of Federal Regulations, 2013 CFR

...stenocephala ), whipworms (Trichuris vulpis ), ascarids (Toxocara canis and Toxascaris leonina ), and tapeworms (Dipylidium...removal of hookworms (Ancylostoma tubaeforme ), ascarids (Toxocara cati ) and tapeworms (Dipylidium caninum and Taenia...

2013-04-01

227

21 CFR 520.1199 - Ivermectin, pyrantel, and praziquantel tablets.  

...heartworm larvae (Dirofilaria immitis ) for 1 month (30 days) after infection and for the treatment and control of roundworm (Toxocara canis, Toxascaris leonina ), hookworm (Ancylostoma caninum, Uncinaria stenocephala, Ancylostoma braziliense )...

2014-04-01

228

Evolutionary scenario for W UMa-type stars  

NASA Astrophysics Data System (ADS)

An alternative to TRO model of a W UMa-type star is presented in which the binary is past mass exchange with mass ratio reversal. The secondary is hydrogen depleted and both components are in thermal equilibrium. Evolution in contact is driven by orbital angular momentum loss and mass transfer from the secondary to primary component, similarly as it is observed in Algols. Temperature equalization of both components results from an assumed energy transfer by a large scale flow encircling the whole system in the common envelope.

Stepie?, K.; Gazeas, K.

2008-10-01

229

FUSE Observations of the Dwarf Nova SW UMa During Quiescence  

E-print Network

We present spectroscopic observations of the short-period cataclysmic variable SW Ursa Majoris, obtained by the Far Ultraviolet Spectroscopic Explorer (FUSE) satellite while the system was in quiescence. The data include the resonance lines of O VI at 1031.91 and 1037.61 A. These lines are present in emission, and they exhibit both narrow (~ 150 km/s) and broad (~ 2000 km/s) components. The narrow O VI emission lines exhibit unusual double-peaked and redshifted profiles. We attribute the source of this emission to a cooling flow onto the surface of the white dwarf primary. The broad O VI emission most likely originates in a thin, photoionized surface layer on the accretion disk. We searched for emission from H_2 at 1050 and 1100 A, motivated by the expectation that the bulk of the quiescent accretion disk is in the form of cool, molecular gas. If H_2 is present, then our limits on the fluxes of the H_2 lines are consistent with the presence of a surface layer of atomic H that shields the interior of the disk. These results may indicate that accretion operates primarily in the surface layers of the disk in SW UMa. We also investigate the far-UV continuum of SW UMa and place an upper limit of 15,000 K on the effective temperature of the white dwarf.

M. S. Povich; J. C. Raymond; A. Lobel; K. Menou

2004-09-24

230

*Bacharel em Turismo.  

E-print Network

algumas questões que ainda fazem parte das discussões sobre as necessárias reformas estatais originadas no período da transição democrática e que se estendem até os dias atuais. Discussões essas que incluem também as transformações ocorridas na sociedade e que colocam as propostas de reformas para além da estrutura do Estado. É neste período que se pronuncia o esgotamento do planejamento centralizado como instrumento de condução política, não só em função dos problemas intrínsecos à estrutura estatal, mas principalmente por este não conseguir planejar a sociedade em virtude da nova complexidade social. Aliás, complexidade é a noção predominante nesse contexto em que se abrem novas propostas de planejamento, definidas através da co-responsabilidade entre os representantes do Estado e da

Ana Valéria Endres; Palavras-chave Turismo; Estado Planejamento; Planejamento Turístico

231

EM Radiation Program  

NSDL National Science Digital Library

The EM Radiation program displays the electric field vectors (in the x-y plane) and magnetic field contours (for the field in the z direction) calculated from the Lienard-Wiechert potentials for a charged particle. The default scenario shows the resulting radiation from a charged particle in simple harmonic motion. Additional particle trajectories can be specified using the Display | Switch GUI menu item. EM Radiation is an Open Source Physics program written for the teaching of electromagnetism. It is distributed as a ready-to-run (compiled) Java archive. Double clicking the em_radiation.jar file will run the program if Java is installed. Other electromagnetism programs are also available. They can be found by searching ComPADRE for Open Source Physics, OSP, or electromagnetism.

Christian, Wolfgang

2008-05-20

232

Predação de embriões por girinos de Bokermannohyla alvarengai (Anura, Hylidae) em riacho temporário na Serra do Ouro Branco, Minas Gerais, Brasil  

Microsoft Academic Search

RESUMO: O comportamento oofágico e o canibalismo são bastante difundidos entre girinos de diversas famílias de anuros, sendo o último particularmente comum em ambientes temporários, tais como o riacho do presente estudo. Este artigo relata um evento de predação no campo, no qual girinos de Bokermannohyla alvarengai se alimentaram de embriões co-específicos. Esta é uma importante fonte de alimento com

Vinícius A. São Pedro; Leandro O. Drummond; Henrique C. Costa; Vítor D. Fernandes; Renato N. Feio

233

Comprehensive photometric study of the eclipsing binary AW UMa  

NASA Astrophysics Data System (ADS)

Due to its extreme mass ratio, the system AW UMa is considered as one of the most interesting contact binaries. In the present paper, a total of 1289 observations in VRI band were carried out from on 2006 March 7, 8, and 9 at Piszkesteto, Mountain Station of the Konkoly observatory (Hungary). VRI light curves were constructed and a photometric solution of these light curves was obtained by means of Willson-Devinney code. The results show that the primary component is more massive and hotter than the primary component by ˜140 K. A secular period decrease with a rate dP/ dE=2.436×10-10 day/cycle was detected. Based on the physical parameters of the system, we investigate the evolutionary state of the components. The primary component is above the zero age main sequence (ZAMS) track, while the secondary component has a larger radius and luminosity than expected from its ZAMS mass.

Elkhateeb, M. M.; Nouh, M. I.

2014-08-01

234

Recent developments on SU UMa stars - theory vs. observation  

NASA Astrophysics Data System (ADS)

Kepler light curves of short period dwarf novae have resparked interest in the nature of superoutbursts and led to the question: Is the thermal-tidal instability needed, or can the plain vanilla version of the accretion disk limit cycle do the job all by itself? A detailed time-resolved study of an eclipsing SU UMa system during superoutburst onset should settle the question - if there is a dramatic contraction of the disk at superoutburst onset, Osaki's thermal-tidal model would be preferred; if not, the plain disk instability model would be su?cient. I will present recent results that support the contention by Osaki & Kato that the time varying negative superhump frequencies can be taken as a surrogate for the outer disk radius variations. Finally, it may be necessaryto look beyond the short period dwarf novae to gain perspective on the nature of embedded precursors in long outbursts.

Cannizzo, John K.

2015-01-01

235

The EM Earthquake Precursor  

NASA Astrophysics Data System (ADS)

Many attempts have been made to determine a sound forecasting method regarding earthquakes and warn the public in turn. Presently, the animal kingdom leads the precursor list alluding to a transmission related source. By applying the animal-based model to an electromagnetic (EM) wave model, various hypotheses were formed, but the most interesting one required the use of a magnetometer with a differing design and geometry. To date, numerous, high-end magnetometers have been in use in close proximity to fault zones for potential earthquake forecasting; however, something is still amiss. The problem still resides with what exactly is forecastable and the investigating direction of EM. After the 1989 Loma Prieta Earthquake, American earthquake investigators predetermined magnetometer use and a minimum earthquake magnitude necessary for EM detection. This action was set in motion, due to the extensive damage incurred and public outrage concerning earthquake forecasting; however, the magnetometers employed, grounded or buried, are completely subject to static and electric fields and have yet to correlate to an identifiable precursor. Secondly, there is neither a networked array for finding any epicentral locations, nor have there been any attempts to find even one. This methodology needs dismissal, because it is overly complicated, subject to continuous change, and provides no response time. As for the minimum magnitude threshold, which was set at M5, this is simply higher than what modern technological advances have gained. Detection can now be achieved at approximately M1, which greatly improves forecasting chances. A propagating precursor has now been detected in both the field and laboratory. Field antenna testing conducted outside the NE Texas town of Timpson in February, 2013, detected three strong EM sources along with numerous weaker signals. The antenna had mobility, and observations were noted for recurrence, duration, and frequency response. Next, two directional techniques were employed, resulting in three mapped, potential epicenters. The remaining, weaker signals presented similar directionality results to more epicentral locations. In addition, the directional results of the Timpson field tests lead to the design and construction of a third prototype antenna. In a laboratory setting, experiments were created to fail igneous rock types within a custom-designed Faraday Cage. An antenna emplaced within the cage detected EM emissions, which were both reproducible and distinct, and the laboratory results paralleled field results. With a viable system and continuous monitoring, a fracture cycle could be established and observed in real-time. Sequentially, field data would be reviewed quickly for assessment; thus, leading to a much improved earthquake forecasting capability. The EM precursor determined by this method may surpass all prior precursor claims, and the general public will finally receive long overdue forecasting.

Jones, K. B., II; Saxton, P. T.

2013-12-01

236

Alocac~ao de Clientes em Grupos Usando Classificac~ao via Boosting : Uma Comparac~ao com os Metodos  

E-print Network

aplica¸c~oes s~ao ´arvores de classifica¸c~ao e redes neurais. Os m´etodos tradicionais apresentam baixo custo computacional, mas s~ao pouco flex´iveis, enquanto os m´etodos como redes neurais s~ao muito flex´alise discriminante [Johnson e Wichern 2002]. Esses m´etodos, cujos fundamentos est~ao estabelecidos na teoria estat

Dias, Ronaldo

237

Correlações genéticas entre diâmetro de fibras musculares e características de qualidade de carne em uma linhagem macho de frangos1  

Microsoft Academic Search

Data from a broiler selection program were used to estimate the genetic correlation for muscle fibers diameter and meat quality traits. Genetic correlation was estimated by restricted maximum likelihood method, using the software MTDFREML, with relationship matrix with 77.474 animals. Estimate of genetic correlation among muscle fiber diameter and a* (color parameter - redness) was 0.40 and between diameter and

Andrezza Maria Felício; José Bento Sterman Ferraz; Júlio César de Carvalho; Joanir Pereira Eler; Elisângela Chicaroni de Mattos; Jane Lara Brandani; Marques Grosso; Leila de Genova Gaya; Cristina Tschorny Moncau; Maria Elisa Bueno da Silva; Rodrigo Müller de Souza

238

A Viabilidade do Gerenciamento de Desempenho Pró-ativo Baseado em uma Arquitetura de Gerenciamento que usa Tecnologia Ativa  

Microsoft Academic Search

Resumo A garantia de níveis qualidade de serviço específicos depende fundamental- mente da presença de um mecanismo de gerenciamento preciso, eficiente e rápido, tanto dos recursos da rede quanto das aplicações e dos serviços de comunicação. Esse mecanismo de gerenciamento deve ser de fácil atualização e flexível o suficien- te para a implantação de novas funcionalidades com a devida rapidez.

Edmundo Lopes Cecilio; Ana Paula; Magalhães Dumont; Flávia Coimbra Delicato

239

DESENVOLVIMENTO E IMPLEMENTAÇÃO DE UMA BASE COMPUTACIONAL ORIENTADA A OBJETOS PARA APLICAÇÕES EM SISTEMAS DE ENERGIA ELÉTRICA  

Microsoft Academic Search

This paper describes the application of the Object-Oriented Programming (OOP) on the modeling of Power Systems. It is intend to develop a computational object-oriented base to represent, in an efficient way, the physical component s of a Power System and their methodologies of analysis and synthesis. The generalization level of the classes' structure allows fut ure specializations, on the side

MARCELO N. AGOSTINI; ILDEMAR C. DECKER; AGUINALDO S. E SILVA

2000-01-01

240

UMA PROPOSTA PEDAGÓGICA PARA O USO DA MODELAGEM COMPUTACIONAL NO CURSO DE LICENCIATURA EM QUÍMICA DO CEFET CAMPOS  

Microsoft Academic Search

This study presents an experiment on the use of a simulation and modelling computer environment in the teaching of Physical Chemistry. The research was conducted with students attending the Chemistry Teaching program at Cefet Campos aiming at: examining the contribution of using Modellus in the teaching and learning process, promoting a cooperative and collaborative learning environment among students, and observe

Rodrigo Garrett da Costa

241

Programa de Ps-Graduao em Engenharia de Transportes e Gesto Territorial PPGTG PPGTG -Gesto Carlos Loch  

E-print Network

modelo padrão (modelo 2); Uma foto 3x4 recente; Cópia do CPF e do RG; #12;Programa de Pós-Graduação em Educação e/ou pelo Ministério de Relações Exteriores do Brasil; e Os modelos 1, 2 e 3 acima poderão ser Catarina / Brasil #12;Programa de Pós-Graduação em Engenharia de Transportes e Gestão Territorial ­ PPGTG

Floeter, Sergio Ricardo

242

IX Draconis - a curious ER UMa-type dwarf nova  

NASA Astrophysics Data System (ADS)

We report results of an extensive worldwide observing campaign devoted to a very active dwarf nova star - IX Draconis. We investigated photometric behaviour of the system to derive its basic outburst properties and understand peculiarities of IX Draconis as well as other active cataclysmic variables, in particular dwarf novae of the ER UMa type. In order to measure fundamental parameters of the system, we carried out analyses of the light curve, O - C diagram, and power spectra. During over two months of observations, we detected two superoutbursts and several normal outbursts. The V magnitude of the star varied in the range 14.6-18.2 mag. Superoutbursts occur regularly with the supercycle length (Psc) of 58.5 ± 0.5 d. When analysing data over the past 20 years, we found that Psc is increasing at a rate of dot{P} = 1.8 × 10^{-3}. Normal outbursts appear to be irregular, with typical occurrence times in the range 3.1-4.1 d. We detected a double-peaked structure of superhumps during superoutburst, with the secondary maximum becoming dominant near the end of the superoutburst. The mean superhump period observed during superoutbursts is Psh = 0.066982(36) d (96.45 ± 0.05 min), which is constant over the last two decades of observations. Based on the power spectrum analysis, the evaluation of the orbital period was problematic. We found two possible values: the first one, 0.066 41(3) d (95.63 ± 0.04 min), which is in agreement with previous studies and our O - C analysis [0.06646(2) d, 95.70 ± 0.03 min], and the second one, 0.06482(3) d (93.34 ± 0.04 min), which is less likely. The evolutionary status of the object depends dramatically on the choice between these two values. A spectroscopic determination of the orbital period is needed. We updated available information on ER UMa-type stars and present a new set of their basic statistics. Thereby, we provide evidence that this class of stars is not uniform.

Otulakowska-Hypka, M.; Olech, A.; de Miguel, E.; Rutkowski, A.; Koff, R.; B?kowska, K.

2013-02-01

243

Polarização da cárie dentária em pré-escolares cadastrados no Programa Saúde da Família do Recife Polarization of Dental Caries in Pre-scholars registered in The Family Health Plan in the City of Recife  

Microsoft Academic Search

Key-words Este estudo determinou a prevalência e gravidade de cárie em crianças de 18-36 meses e 5 anos cadastradas no Programa Saúde da Família do Distrito Sanitário IV\\/Recife, em 2006. Estimou-se uma amostra probabilística de 1500 crianças: 900 de 18-36 meses e 600 de 5 anos, calculada com 27% e 65 % de prevalência e 5% e 6,5% de erro,

Márcia M; Dantas Cabral de Melo; Wayner Vieira de Souza; Maria Luiza Lima de Carvalho; Geraldo Bosco; Lindoso Couto

244

SIMULAÇÃO MONTE CARLO DE UMA CÂMARA GAMA COM O CÓDIGO GEANT4  

Microsoft Academic Search

Neste trabalho foi simulada uma câmara gama Siemens E. Cam Dual Head, através de métodos de Monte Carlo utilizando o código GEANT4, com o objectivo de melhor compreender o desempenho dos sistemas existentes e contribuir para o desenvolvimento de novos e melhores detectores para imagiologia médica, com radiações ionizantes. As simulações Monte Carlo validadas através de resultados experimentais, constituem uma

S. Rodrigues; B. Tomé; M. C. Abreu; N. Santos

245

Correlação de longo alcance em sistemas binários de raios-x usando remoção de flutuações  

NASA Astrophysics Data System (ADS)

Neste trabalho é proposta uma metodologia de analise de series temporais de fontes astrofísicas, baseada no método proposto por Peng et al. (1994) e Liu et al. (1999), o qual consiste na idéia de que uma série temporal correlacionada pode ser mapeada por um processo de busca de auto-similaridades em diversas escalas de tempo n. Removendo as eventuais tendências e integrando o sinal observado, é obtida uma medida do desvio médio quadrático das flutuações do sinal integrado F(n)~na, onde a representa o fator de escala associado com a auto-similaridade da correlação de longo alcance do sinal. Baseado nos valores obtidos de a, é possível distinguir entre os casos de sinais não-correlacionados, tipo ruído branco (a = 0,5), sinal anti-persistentes (a < 0,5) e sinal persistente (a > 0,5). Usando esta metodologia, foram analisadas 129 curvas de luz de sistemas binários de raios-X, provenientes do banco de dados públicos de observações feitas pelo instrumento All Sky Monitor, a bordo do satélite Rossi X-Ray Timing Explorer (ASM-RXTE). Foram identificadas a presença de a'0,5 em mais de 90% dos sistemas estudados, implicando em dizer que as flutuações de intensidade observadas apresentam correlação de auto-similaridade, sem entretanto, indícios de apresentarem uma escala de tempo característica das flutuações de intensidade. Sistemas onde são observadas erupções (flares), apresentam sistematicamente a > 0,5, característica esta, possivelmente associada com persistência das flutuações de densidade de disco ou taxa de acréscimo de massa. Os sistemas com curvas de luz onde nao são observadas as erupções apresentam uma distribuição normal centrada em a~0,62+/-0,10. Referências ¾ Peng, C.-K., Buldyrev, S.V., Havlin, S., Simons, M., Stanley, H.E., e Goldberg, A.L., Phys. Rev. E, (49), 1685 (1994). ¾ Liu, Y., Gopikrishnan, P., Cizeau, P., Meyer, M., Peng,C.-K., e Stanley, H.E., Phys. Rev. E, (60), 1390 (1999).

Pereira, M. G.; Moret, M. A.; Zebende, G. F.; Nogueira, E., Jr.

2003-08-01

246

Diagnóstico de multicolinearidade em modelos aditivo-dominante em uma população de bovinos de corte compostos (Bos taurus x Bos indicus)  

Microsoft Academic Search

The purpose of this study was to investigate the effect of multicollinearity in two genetic models used to estimate additive and heterotic effects at birth, weaning and yearling weights. The age of dam class at calving, the additive direct and maternal genetic effects, and the direct and total maternal heterozygosis effects were included in the complete model. The reduced model

Gerson Barreto Mourão; Juliana Petrini; Raphael Antonio Prado Dias; Joanir Pereira Eler; José Bento Sterman Ferraz; Julio César; Carvalho Balieiro; Elisângela Chicaroni Mattos

247

CCD Photometry of the W UMa type star QX Andromeda  

NASA Astrophysics Data System (ADS)

We present new B- and V-band photometry of the W UMa-type binary system QX And, which is a member of the open cluster NGC 752. Revised orbital period and new ephemerides were given for the binary system based on the data of times of light minima. The result of a period analysis reveals that the system is undergoing a continuous orbital period increase during the past decades. The rate of period increasing turns out to be about 2.7 × 10 -7 d yr -1. With the Wilson-Devinney code, a photometric solution is computed. It yields a contact configuration for the system with a filling factor of 0.361. Combining the results from the photometric solution along with that from the radial-velocity observations, we have determined the absolute parameters for the two components of the system. The masses, radii and luminosity of the primary and secondary stars are calculated as 1.43 ± 0.04 M?, 1.45 ± 0.09 R?, 2.87 ± 0.40 L? and 0.44 ± 0.02 M?, 0.87 ± 0.05 R?, 0.99 ± 0.13 L?, respectively. The evolutionary status and physical nature of the contact binary system were discussed compared with the theoretical models.

Ren, A. B.; Zhang, X. B.; Luo, C. Q.; Luo, Y. P.; Deng, L. C.; Luo, Z. Q.

2011-04-01

248

Spectroscopic Metallicity Determinations for W UMa-type Binary Stars  

NASA Astrophysics Data System (ADS)

This study is the first attempt to determine the metallicities of W UMa-type binary stars using spectroscopy. We analyzed about 4500 spectra collected at the David Dunlap Observatory. To circumvent problems caused by the extreme spectral line broadening and blending and by the relatively low quality of the data, all spectra were subject to the same broadening function (BF) processing to determine the combined line strength in the spectral window centered on the Mg I triplet between 5080 Å and 5285 Å. All individual integrated BFs were subsequently orbital-phase averaged to derive a single line-strength indicator for each star. The star sample was limited to 90 W UMa-type (EW) binaries with the strict phase-constancy of colors and without spectral contamination by spectroscopic companions. The best defined results were obtained for an F-type sub-sample (0.32 < (B - V)0 < 0.62) of 52 binaries for which integrated BF strengths could be interpolated in the model atmosphere predictions. The logarithmic relative metallicities, [M/H], for the F-type sub-sample indicate metal abundances roughly similar to the solar metallicity, but with a large scatter which is partly due to combined random and systematic errors. Because of the occurrence of a systematic color trend resulting from inherent limitations in our approach, we were forced to set the absolute scale of metallicities to correspond to that derived from the m 1 index of the Strömgren uvby photometry for 24 binaries of the F-type sub-sample. The trend-adjusted metallicities [M/H]1 are distributed within -0.65 < [M/H]1 < +0.50, with the spread reflecting genuine metallicity differences between stars. One half of the F-sub-sample binaries have [M/H]1 within -0.37 < [M/H]1 < +0.10, a median of -0.04 and a mean of -0.10, with a tail toward low metallicities, and a possible bias against very high metallicities. A parallel study of kinematic data, utilizing the most reliable and recently obtained proper motion and radial velocity data for 78 binaries of the full sample, shows that the F-type sub-sample binaries (44 stars with both velocities and metallicity determinations) have similar kinematic properties to solar-neighborhood, thin-disk dwarfs with space velocity component dispersions: ?U = 33 km s-1, ?V = 23 km s-1 and ?W = 14 km s-1. FU Dra with a large spatial velocity, V tot = 197 km s-1 and [M/H]1 = -0.6 ± 0.2, appears to be the only thick-disk object in the F-type sub-sample. The kinematic data indicate that the F-type EW binaries are typical, thin-disk population stars with ages about 3-5.5 Gyr. The F-type binaries that appear to be older than the rest tend to have systematically smaller mass ratios than most of the EW binaries of the same period. Based on observations obtained at the David Dunlap Observatory, University of Toronto.

Rucinski, Slavek M.; Pribulla, Theodor; Budaj, Ján

2013-09-01

249

ANÁLISE DA INSERÇÃO DOS TEMAS DE HUMANIDADES E ÉTICA, COM METODOLOGIA DE APRENDIZAGEM BASEADA EM PROBLEMAS, EM CURRICULO MÉDICO INTEGRADO EM ESCOLA PÚBLICA NO DISTRITO FEDERAL, BRASIL  

PubMed Central

Objetivo Realizar uma análise da inserção da ética e humanidades no currículo do Curso de Medicina da Escola Superior em Ciências da Saúde - ESCS, escola pública do Distrito Federal, Brasil, de forma a contribuir com o processo de gestão curricular. Metodologia O Estudo é de coorte e documental. Foram pesquisados 37 termos relacionados à ética e 36 referentes à humanização nos objetivos educacionais e conteúdo dos módulos temáticos, habilidades e atitudes e interação ensino-serviço-comunidade, de 1a a 4a série e no programa do internato no currículo (ano 2006) e no projeto pedagógico do Curso de Medicina (2001). Resultados Maior inserção da humanização, ética e bioética na 1a e 2a série, quando comparado à inserção na 3a e 4a série e no internato, (IC95%-?=0,034, pvalue=0,007). Unidade de habilidades e atitudes: freqüência das 3 temáticas no currículo da 1a a 4a séries (IC95%-?=0,026, pvalue=0,013). Quando comparada a inserção entre o internato e as quatro primeiras séries, observa-se que nestas a inserção da temática humanização é superior (IC95%-?=0,042, pvalue=0,029). Conclusão O currículo desenvolvido no ano de 2006 na ESCS apresentou correlação com o projeto pedagógico do curso e contemplou a temática de forma abrangente, em todas as séries e internato. PMID:20396594

Novaes, Maria Rita Carvalho Garbi; Novaes, Luiz Carlos Garcez; Guilhem, Dirce; Lolas, Fernando; Silveira, Carla; Guiotti, Murilo

2009-01-01

250

Fundamental data for contact binaries: RZ Comae, RZ Tauri, and AW UMa  

NASA Technical Reports Server (NTRS)

Differential corrections analyses of three W UMa type binaries show that RZ Tau and AW UMa have common envelopes and the relatively small gravity darkening predicted by Lucy, while RZ Comae seems to have a larger gravity effect and is only marginally in contact. Some details of the method for computing contact binary light curves are given. It is suggested that W UMa binaries which have occultation primary eclipses may, in general, have large amplitudes for gravity darkening or a photometric surface brightness effect which simulates large gravity darkening.

Wilson, R. E.; Devinney, E. J.

1972-01-01

251

New Light Curves and Period Studies of V502 OPH W UMA System  

NASA Astrophysics Data System (ADS)

NEW LIGHT CURVES AND PERIOD STUDIES OF V502 OPH W UMa SYSTEM N.S.Awadalla National Research Institute of Astronomy and Geophysics( NRIAG ) Helwan Cairo EGYPT New BVR photoelectric observations of the W UMa eclipsing binary system V502 Oph have been presented and analyzed. The geometric and physical elements of the system have been obtained and compared to the previous results. The classification of the system concerning the sub-type of the W UMa binary has been studied as well as its evolution stage. Its period variation in a view of the light time effect has been examin

Awadalla, Nabil S.

252

The 1994 Superoutburst of the New SU UMa-type Dwarf Nova, SX Leonis Minoris  

NASA Astrophysics Data System (ADS)

We present observations of SX LMi obtained during the 1994 long outburst at Ouda Station. Superhumps, with a period of 0.06950 (\\pm 0.00002) d, are detected. This confirms SX LMi as a new member of the SU UMa-type dwarf novae. We measured the recurrence cycle of normal outbursts and superoutbursts to be about 35 d and 250 d, repsectively, from outburst records by RoboScope (Indiana University) and amateur observers. These recurrence cycles are typical values for normal SU UMa stars. However, the outburst amplitude (\\sim3.8 mag) of SX LMi is small for an SU UMa star and close to those of ER UMa stars. This small outburst amplitude might be understood if the viscosity at quiescence and the mass-transfer rate are slightly high in SX LMi. (SECTION: Stars)

Nogami, D.; Masuda, S.; Kato, T.

1997-10-01

253

EPA LABORATORIES IMPLEMENT EMS PROGRAM  

EPA Science Inventory

This paper highlights the breadth and magnitude of carrying out an effective Environmental Management System (EMS) program at the U.S. EPA's research and development laboratories. Federal research laboratories have unique operating challenges compared to more centralized industr...

254

The Intermediate Polar EI UMa: A Pre-Polar Cataclysmic Variable  

E-print Network

We present optical and X-ray time-series photometry of EI UMa that reveal modulation at 746 and 770 s, which we interpret as the white dwarf spin and spin-orbit sidebands. These detections, combined with previous X-ray studies, establish EI UMa as an intermediate polar. We estimate the mass accretion rate to be ~ 3.6 x 10^{17} g s^{-1}, which is close to, and likely greater than, the critical rate above which dwarf nova instabilities are suppressed. We also estimate the white dwarf to have a large magnetic moment mu > (3.4 +/- 0.2) x 10^{33} G cm^3. The high mass accretion rate and magnetic moment imply the existence of an accretion ring rather than a disk, and along with the relatively long orbital period, these suggest that EI UMa is a rare example of a pre-polar cataclysmic variable.

Tamara W. Reimer; William F. Welsh; Koji Mukai; F. A. Ringwald

2008-02-24

255

X-ray-selected candidates for the RS CVn and W UMa classes of binary stars  

NASA Technical Reports Server (NTRS)

X-ray luminosity, spectral type, radial-velocity variation, rotationally broadened line profile, and Ca II H and K line emission data are used to identify 12 new candidates for the RS CVn class and seven new candidates for the W UMa class from spectroscopic binaries which are contained in the Einstein Extended Medium Sensitivity Survey. Under the assumption that the candidates are genuine members of each class, local space density estimates of 4.47 + or - 1.19 x 10 to the -4th/cu pc for RS CVn binaries and 8.47 + or - 3.00 x 10 to the -5th/cu pc for W UMa binaries are found. Although the density estimate for the W UMa binaries is shown to be consistent with previous estimates obtained from optically selected samples, the estimate for the RS CVn binaries is more than an order of magnitude greater than previously determined space densities.

Fleming, Thomas A.; Gioia, Isabella M.; Maccacaro, Tommaso

1989-01-01

256

Aquecimento alfvênico viscoso-resistivo em discos de acresção ao redor de estrelas T Tauri clássicas  

NASA Astrophysics Data System (ADS)

Com a crescente disponibilidade de dados observacionais sobre estrelas T Tauri, a busca por modelos mais precisos vem se tornando cada vez maior. Estes modelos devem explicar, entre outras coisas, o mecanismo dissipativo responsável pelo transporte de momento angular no disco de acresção que acredita-se, circunda estas estrelas. O mecanismo mais viável, do ponto de vista teórico, é uma instabilidade MHD conhecida como "instabilidade magnetorotacional ou Balbus-Hawley" (IBH). Esta instabilidade veio mostrar que o campo magnético desempenha um papel importante na evolução destes objetos mas requer, no entanto, um acoplamento mínimo entre o gás e o campo magnético no disco que não é atingido para os valores de temperatura obtidos do modelo padrão. Contudo, alguns mecanismos de aquecimento para o disco precisam ser examinados. Neste trabalho, propomos a dissipação de ondas Alfvén como uma fonte de aquecimento para o disco. Se o gás apresentar uma condutividade elétrica finita e viscosidade, teremos um tipo de amortecimento para as ondas denominado amortecimento viscoso-resistivo que será aqui considerado. Este mecanismo é aplicado ao modelo de disco em camadas. Calculam-se as taxas de aquecimento Alfvênico, a temperatura efetiva do disco bem como as taxas de ionização decorrentes deste aquecimento e do aquecimento gerado pela absorção de raios cósmicos. Comparações com os dados observacionais de Kitamura et. al. (2001) são efetuadas, ressaltando-se os pontos comuns entre suas observações e nossos dados teóricos.

Santana, W. M.; Vasconcelos, M. J.

2003-08-01

257

Produção de hidrolases pelo fungo Dicyma pulvinata, e purificação de uma beta-glucanase do isolado CEN62.  

E-print Network

??Dissertação (mestrado)—Universidade de Brasília, Instituto de Ciências Biológicas, Departamento de Biologia Celular, 2009. A seringueira (Hevea spp.) é uma planta nativa da região amazônica, da… (more)

Agustinho, Daniel Paiva

2009-01-01

258

Projeto educação em ciências com observatórios virtuais: a participação da Escola Moppe no período 2000-2003  

NASA Astrophysics Data System (ADS)

O projeto Educação em Ciências com Observatórios Virtuais foi concebido pelo Instituto Astronômico e Geofísico da USP, agregando diversas instituições de ensino e pesquisa no país para desenvolver competências diversas na educação fundamental, média e superior utilizando a astronomia como ferramenta multidisciplinar. Este trabalho descreve a participação da MOPPE, escola-piloto do INPE no projeto, no período de 2000-2003. Serão apresentadas 1) a criação de um clube de ciências (1999 a 2001) cujo tema foi a colonização de Marte e 2) a ementa de astronomia trabalhada com as 7a. e 8a. séries do ensino fundamental. A proposta do projeto Colonizando Marte foi estudar diversos aspectos de uma missão interplanetária e construir experiementos que permitissem quantificar esses aspectos. Os resultados obtidos incluiram apresentações nas SBPC Jovem em 2000 e 2001. Discutiremos também as ementas de astronomia trabalhadas desde 2001 e o envolvimento dos alunos com atividades ligadas a astronomia, fora da aula de ciências. A inclusão de astronomia no currículo das últimas séries motivou a participação de mais alunos culminando com a conquista de duas medalhas para alunos da 7a. série na Olimpiada Brasileira de Astronomia em 2002. Houve também um aumento no número de participantes na OBA 2003 e nos projetos de astronomia mais elaborados nas Feira de Ciências de 2001 e 2002. Destacamos em 2003 a inclusão da MOPPE no projeto TIE - Telescopes in Education - da NASA, que utiliza o telescópio do Observatório de Mount Wilson (EUA) para observações remotas em projetos pedagógicos para o ensino de astronomia.

Wuensche, C. A.; Gavioli, E.; Oliveira, A. L. P. R. S.; da Silva, C.; Cardoso, H. P.; Estácio, S.

2003-08-01

259

Mobile Identity Management: An Enacted View George Roussos, Don Peterson, and Uma Patel  

E-print Network

telecommunications infrastructures. Mobile identity management is used to identify, acquire, access and payMobile Identity Management: An Enacted View George Roussos, Don Peterson, and Uma Patel Abstract, mobile identity management can play a central role to address usability and trust issues in mobile

Roussos, George

260

LIDA: A Working Model of Cognition Uma Ramamurthy (urmmrthy@memphis.edu)  

E-print Network

LIDA: A Working Model of Cognition Uma Ramamurthy (urmmrthy@memphis.edu) University of Memphis present the LIDA architecture as a working model of cognition. We argue that such working models are broad on specific pieces of cognition. While experimentally based models are useful, we need a working model

Memphis, University of

261

A EXTENSÃO OFICIAL NO BRASIL: UMA AVALIAÇÃO DIAGNÓSTICA. O CASO DO NORDESTE  

Microsoft Academic Search

Este trabalho é resultado de uma investigação sobre a ação dos órgãos oficiais de Assistência Técnica e Extensão rural (ATER) no nordeste brasileiro, com o objetivo avaliar as ações dos mesmos visando a implementação da nova Política Nacional de ATER (PNATER), na região como referência para o país. Ela contemplou os Estados de Bahia, Pernambuco, Paraíba, Rio Grande do Norte,

José Ribamar; Furtado de Souza

262

Orientation in a desert lizard ( Uma notata ): time-compensated compass movement and polarotaxis  

Microsoft Academic Search

The diurnal escape response of fringetoed lizards (Uma notata) startled by predators demonstrates clear directional orientation not likely to depend on local landmarks in the shifting sands of their desert environment. Evidence that celestial orientation is involved in this behavior has been sought in the present experiments by testing the effects of (1) phase shifting the animal's internal clock by

Kraig Adler; John B. Phillips

1985-01-01

263

ONDAS ELETROMAGNÉTICAS, CIRCUITOS E ANTENAS: UMA PROPOSTA DE ENSINO QUE BUSCA A COMPLEXIFICAÇÃO DO CONHECIMENTO COTIDIANO  

Microsoft Academic Search

RESUMO O desenvolviment o da ciência e as suas respectivas aplicações tecnológicas ocorrem com tamanha rapidez que o sistema de ensino atual raramente consegue contemplar a inse rção desses novos conteúdos no E nsino Médio. Especialmente no ensino de física, os conteúdos ensinados estão muito distantes da realidade vivencial cotidiana do aluno. O presente trabalho apresenta uma proposta de ensino

Nelson Fiedler-Ferrarab

264

Violência sexual contra crianças e adolescentes : uma análise de discurso crítica no âmbito terapêutico.  

E-print Network

??Tese (doutorado)—Universidade de Brasília, Instituto de Letras, Departamento de Linguística, Português e Línguas Clássicas, Programa de Pós-Graduação em Linguística, 2014. O objetivo desta pesquisa é… (more)

Silva, Sandro Xavier da

2014-01-01

265

Angus Robichaud's Reel G Em D A Bm D7  

E-print Network

Angus Robichaud's Reel 4 4 D G A D D G A D 3 3 G Em D A Bm D7 3 3 G Em D A D Animas Reel Bernie Waugh 4 4 3 3 G D G Bm Em C Am C D G D G Bm Em C Am D G The Arkansas Traveler 4 2 D G A D Em A 3D G A D Em G A D D G D A Bm Em A D G D A Em G A D #12;Asher Rodney Miller 4 4 D Em F#m G A D Em G A D A D1 2

Doyle, Peter

266

Angus Robichaud's Reel G Em D A Bm D7  

E-print Network

Angus Robichaud's Reel 4 4 D G A D D G A D 3 3 G Em D A Bm D7 3 3 G Em D A D Animas Reel Bernie Waugh 4 4 3 3 G D G Bm Em C Am C D G D G Bm Em C Am D G The Arkansas Traveler 4 2 D G A D Em A 3 D G A D Em G A D D G D A Bm Em A D G D A Em G A D #12; Asher Rodney Miller 4 4 D Em F#m G A D Em G A D A D 1

Doyle, Peter

267

Correlation of the NBME Advanced Clinical Examination in EM and the National EM M4 exams  

PubMed Central

Introduction Since 2011 two online, validated exams for fourth-year emergency medicine (EM) students have been available (National EM M4 Exams). In 2013 the National Board of Medical Examiners offered the Advanced Clinical Examination in Emergency Medicine (EM-ACE). All of these exams are now in widespread use; however, there are no data on how they correlate. This study evaluated the correlation between the EM-ACE exam and the National EM M4 Exams. Methods From May 2013 to April 2014 the EM-ACE and one version of the EM M4 exam were administered sequentially to fourth-year EM students at five U.S. medical schools. Data collected included institution, gross and scaled scores and version of the EM M4 exam. We performed Pearson’s correlation and random effects linear regression. Results 303 students took the EM-ACE and versions 1 (V1) or 2 (V2) of the EM M4 exams (279 and 24, respectively). The mean percent correct for the exams were as follows: EM-ACE 74.8 (SD-8.83), V1 83.0 (SD-6.41), V2 78.5 (SD-7.70). Pearson’s correlation coefficient for the V1/EM-ACE was 0.51 (0.42 scaled) and for the V2/EM-ACE was 0.59 (0.41 scaled). The coefficient of determination for V1/EM-ACE was 0.72 and for V2/EM-ACE = 0.71 (0.86 and 0.49 for scaled scores). The R-squared values were 0.25 and 0.30 (0.18 and 0.13, scaled), respectively. There was significant cluster effect by institution. Conclusion There was moderate positive correlation of student scores on the EM-ACE exam and the National EM M4 Exams.

Hiller, Katherine; Miller, Emily S.; Lawson, Luan; Wald, David; Beeson, Michael; Heitz, Corey; Morrissey, Thomas; House, Joseph; Poznanski, Stacey

2015-01-01

268

Photometric Solutions of W UMa Type Stars: GSC2576-0319 and GSC2584-1731  

NASA Astrophysics Data System (ADS)

High-precision photometric observations were performed in BVI bandpasses using 1m robotic telescope at Mt. Lemmon Observatory for two binary stars, which are reclassified as W UMa-type systems from ROTSE(Robotic Optical Transient Search Experiment) follow-up observations and show peculiar light variations. In order to analyze W UMa-type eclipsing binaries systematically, the light curve analysis script using 2005 version of Wilson-Devinney binary code is constructed. The orbital inclinations of GSC2584-1731 and GSC2576-0319 are 43.^circ5 and 57.^circ6 from light-curve analysis, respectively. Spot model is applied to explain the asymmetric light curve for GSC2584-1731 and the spot parameters are derived.

Lee, Chung-Uk; Lee, Jae Woo; Jin, Ho; Kim, Chun-Hwey

2006-12-01

269

Absolute and geometric parameters of W UMa type contact binary TYC 1174-344-1  

NASA Astrophysics Data System (ADS)

We present the results of our investigation on the geometrical and physical parameters of W UMa-type binary TYC1174-344-1 from analyzed CCD (BVRI) light curves and radial velocity data. The photometric data were obtained in 2009 at Ankara University Observatory (AUO) and the spectroscopic observations were made in 2008 at Astrophysical Observatory of Asiago (Italy). Light and radial velocity observations were analyzed simultaneously by using the well-known Wilson-Devinney (2007 revision) code to obtain absolute and geometrical parameters. According to our solutions, the system is found to be a low mass-ratio A-type W UMa system. Combining our photometric solution with the spectroscopic data, we derived mass and radii of the eclipsing system as M1 = 1.381 M ?, M2 = 0.258 M ?, R1 = 1.449 R ? and R2 = 0.714 R ?. We finally discussed the evolutionary condition of the system.

Gürol, B.; Derman, E.; Saguner, T.; Gürsoytrak, S. H.; Terzio?lu, Z.; Gökay, G.; Demircan, Y.; Okan, A.; Saral, G.

2011-07-01

270

FUSE Observations of the Dwarf Novae UU Aql, BV Cen, and CH UMa in Quiescence  

E-print Network

We report on FUSE spectra of three U Gem-type, long period, dwarf novae, UU Aql, BV Cen and CH UMa taken during their quiescence intervals. We discuss the line identifications in their spectra and attempt to characterize the source(s) of their FUV flux distribution. Archival IUE spectrum of CH UMa and BV Cen in quiescence were identified as having a matching flux level with the FUSE spectra and these were combined with each FUSE spectrum to broaden the wavelength coverage and further constrain model fits. Multi-component synthetic spectral fits from our model grids, consisting of single temperature white dwarfs, two-temperature white dwarfs, accretion disks and white dwarfs plus accretion disks, were applied to the FUSE spectra alone and to the combined FUSE + IUE spectra. We present the results of our model analyses and their implications.

Edward M. Sion; Patrick Godon; Fuhua Cheng; Paula Szkody

2007-04-09

271

VizieR Online Data Catalog: UBVRI differential photometry of DM UMa (Rosario+, 2009)  

NASA Astrophysics Data System (ADS)

During 1993-94 and 2004-08, DM UMa was observed on a total of 82 nights in standard Johnson BV bands with the 34-cm telescope of Vainu Bappu Observatory, Kavalur. All the measurements were made with respect to BD+60 1301 during 1993-94 and with respect to BD+61 1210 during 2004-08. BD+61 1210 and BD+60 1297 were observed as check stars during the first and second periods, respectively. DM UMa was also observed with the 60-cm telescope operated by San Diego State University at Mt Laguna, CA, on a total of 213 nights simultaneously in standard Johnson UBV bands during 1988-89 and in UBVRI bands during 1990-2007. BD+60 1301 was used as the comparison and BD+60 1306 as the check star. (2 data files).

Rosario, M. J.; Heckert, P. A.; Mekkaden, M. V.; Raveendran, A. V.

2010-09-01

272

Absolute and geometric parameters of the W UMa type contact binary V546 And  

NASA Astrophysics Data System (ADS)

We present the results of our investigation on the geometrical and physical parameters of the W UMa-type binary V546 And from analyzed CCD (BVRI) light curves and radial velocity data. The photometric data were obtained in 2010 and 2011 at Ankara University Observatory (AUO) and the spectroscopic observations were made in 2010 at TUBITAK National Observatory (TUG). Light and radial velocity observations were analyzed simultaneously by using the Wilson-Devinney (2013 revision) code to obtain absolute and geometrical parameters. The system was determined to be a W-type W UMa system. Combining our photometric solution with the spectroscopic data we derived masses and radii of the eclipsing system to be M1 = 0.275M?,M2 = 1.083M?,R1 = 0.661R? and R2 = 1.229R? . We finally discuss the evolutionary status of the system.

Gürol, Birol; Bradstreet, David H.; Okan, Abdullah

2015-04-01

273

Lecture 12: EM Radiation (EMR)  

E-print Network

#12;James Clerk Maxwell You! 5 Finally, the pinnacle of EM... E · dA = qencl 0 B · dA = 0 E · dl = E = - dB dt{ Maxwell'sEquations F = q(E + v � B)Lorentz Force Law: Gauss's Law Gauss's Law for Mag. Faraday's Law Ampère's LawB · dl = µ0(Ireal + 0 dE dt ) 6 Must be cool 7 Maxwell's last two equations... B

Tobar, Michael

274

Increasing Supercycle Lengths of Active SU UMa-type Dwarf Novae  

NASA Astrophysics Data System (ADS)

We present observational evidence that supercycle lengths of the most active SU UMa-type stars are increasing during the past decades. We analyzed a large number of photometric measurements from available archives and found that this effect is generic for this class of stars, independently of their evolutionary status. This finding is in agreement with previous predictions and the most recent work of Patterson et al. (2012) on BK Lyn.

Otulakowska-Hypka, M.; Olech, A.

2014-12-01

275

Infrasonic harmonic tremor and degassing bursts from Halema'uma'u Crater, Kilauea Volcano, Hawaii  

Microsoft Academic Search

The formation, evolution, collapse, and subsequent resurrection of a vent within Halema'uma'u Crater, Kilauea Volcano, produced energetic and varied degassing signals recorded by a nearby infrasound array between 2008 and early 2009. After 25 years of quiescence, a vent-clearing explosive burst on 19 March 2008 produced a clear, complex acoustic signal. Near-continuous harmonic infrasonic tremor followed this burst until 4

David Fee; Milton Garcés; Matt Patrick; Bernard Chouet; Phil Dawson; Don Swanson

2010-01-01

276

Photometric Observations of an SU UMa-type Dwarf Nova VW Coronae Borealis during Outbursts  

E-print Network

We report the photometric observations of an SU UMa-type dwarf nova VW CrB during two superoutbursts in 2001 and 2003 and a normal outburst in 2003. Superhumps with a period of 0.07287(1) d were observed during the 2003 superoutburst. The change rate of the superhump period was positive. During the normal outburst, there are some hint of modulation up to a 0.2-mag amplitude. However, any periodicity was not found. The recurrence cycles of the normal outburst and the superoutburst, and the distance were estimated to be > ~50 d, 270-500 d, and 690(+230, -170) pc, respectively. These recurrence cycles are usual values for an SU UMa-type dwarf nova having this superhump period. The superhump period of VW CrB was the longest among those of the SU UMa stars with positive derivatives of the superhump period. The coverage of our observations was, however, not enough, and the variation of the Psh change rate of VW CrB is still unknown. A superhump regrowth and a brightening were seen near the end of the plateau phase. Measuring the deviation of the start timings of the brightening and the superhump regrowth (>2 days in VW CrB) will be a key to reveal the mechanism of these phenomena.

D. Nogami; M. Uemura; R. Ishioka; T. Kato; J. Pietz

2003-12-31

277

A cool stellar companion to the ? Scuti variable star GW UMa  

NASA Astrophysics Data System (ADS)

GW UMa is a new high-amplitude ? Scuti variable star with a period of 0d.20319367. By using a few new determined times of light maximum together with those collected from the literature, the changes in Observed-Calculated (O-C) diagram were analyzed. It is discovered that the O-C curve of GW UMa shows a cyclic variation with a period of 13.2 years and a semi-amplitude of 0.0023 days. The periodic variation was analyzed for the light-travel time effect that may be due to the presence of a stellar companion. The mass of the stellar companion is determined to be M2 sin i=0.11(±0.01)M? when a mass of 1.76 M? for GW UMa is adopted. The two component stars in the binary system are orbiting each other at an orbital separation about 6.5(±0.8) AU. For orbital inclinations i?22.6°, the mass of the companion star would be M2<0.3M? and it is a fully convective star. The detection suggests that hidden stellar companions to bright stars may be not unusual.

Wang, S.-M.; Qian, S.-B.; Li, L.-J.; Zhu, L.-Y.; Zhao, E.-G.; Zhou, X.

2015-01-01

278

The absolute parameters of two W UMa type binaries in Ursa Majoris  

NASA Astrophysics Data System (ADS)

We present the results of simultaneous Wilson-Devinney analyses of light and radial velocity curves of two contact binaries in the constellation Ursa Majoris. We found that HH UMa is an A-subtype W UMa binary, which conflicts with the classification of Han et al. (2014) as a W-subtype. Seasonal variations observed in the light curves of the system are well explained with two cool stellar spots in our solution as opposed to the hot-spot based solution by Han et al. (2014), the presence of which would not cause such rapid period variations. The evolutionary status of the system is in agreement with the findings of our study. We modeled II UMa, another A-subtype overcontact binary, without surface spots and found that its both components have rather low surface gravities indicating an advanced state of evolution pointing to evolved subgiants. The high contact degree (f=74%) supports this viewpoint. Our analysis shows that there is a significant third light contribution, contradicting some of the previous analyses, which lack the detection of the secondary minima as total eclipses because they were not as evident as they are in our light curves.

Y?lmaz, M.; Ba?türk, Ö.; Özavc?, ?.; ?enavc?, H. V.; Selam, S. O.

2015-01-01

279

Os povos indígenas e os Censos do IBGE: Uma experiência brasileira  

Microsoft Academic Search

A importância dos dados quantitativos para os povos indígenas no sentido de atender as suas necessidades específicas e orientar suas próprias políticas e as políticas públicas setoriais adquiriu nos últimos anos um grande interesse nos diversos países. Muito se pode atribuir ao crescimento do volume populacional desta população na última década em diversos países da América Latina. Vários são os

Nilza de Oliveira; Martins Pereira; Marta Maria Azevedo

280

Garcinia cambogia - uma espécie vegetal como recurso terapêutico contra a obesidade?6  

Microsoft Academic Search

Resumo Atualmente, a obesidade é um problema de saúde pública mundial, tanto nos países desenvolvidos como nos em desenvolvimento, apresentando elevação de sua prevalência. A transição nutricional é um processo de modificações seqüenciais no padrão de nutrição e consumo que acompanha mudanças econômicas, sociais e demográficas, e mudanças do perfil de saúde das populações. Este trabalho objetiva abordar a comprovação

Ana C S Santos; Michelle S Alvarez; Priscila B Brandão; Ary G Silva

281

BO Canum Venaticorum and SS Comae Berenices: A Photometric Study of AW UMa-Type Binaries  

NASA Astrophysics Data System (ADS)

BO CVn and SS Com are two short-period W UMa-type binary stars with spectral types earlier than F5. In the present paper new CCD photometric light curves in B, V, and R bands of BO CVn and the first complete light curve in V band of SS Com are presented. The light curves of the two binaries are symmetric, and no variations of the light curves were found for both systems that are quite unlike those of cooler overcontact binaries. These observational properties may suggest weak photospheric dark spot activity in the two systems during the observational time intervals. Photometric solutions of the two W UMa-type binaries were derived by using the 2003 version of the Wilson-Devinney (W-D) method. The new solutions suggest that they are overcontact binary stars with degrees of overcontact of f=40.6% for BO CVn and f=49.6% for SS Com. Our new times of light minimum confirmed the long-time period increases of the two systems, and the rates of continuous period increase were revised. The long-time period increases, the orbital periods, the degrees of overcontact, and the mass ratios all suggest that they are on an evolutionary stage of mass transfer from the less massive component to the more massive one, and SS Com will reach the present evolutionary state of BO CVn. The slow evolution toward extreme mass ratio will cause them finally to coalesce to single stars. Therefore, both of them are AW UMa-type near-coalescent overcontact binary systems.

Qian, S.-B.; Zhu, L.-Y.

2006-02-01

282

Origin of W UMa-type contact binaries - age and orbital evolution  

NASA Astrophysics Data System (ADS)

Recently, our understanding of the origin of W UMa-type contact binaries has become clearer. Initial masses of their components were successfully estimated by Y?ld?z and Do?an using a new method mainly based on observational properties of overluminous secondary components. In this paper, we continue to discuss the results and make computations for age and orbital evolution of these binaries. It is shown that the secondary mass, according to its luminosity, also successfully predicts the observed radius. While the current mass of the primary component is determined by initial masses, the current secondary mass is also a function of initial angular momentum. We develop methods to compute the age of A- and W-subtype W UMa-type contact binaries in terms of initial masses and mass according to the luminosity of the secondaries. Comparisons of our results with the mean ages from kinematic properties of these binaries and data pertaining to contact binaries in open and globular clusters have increased our confidence on this method. The mean ages of both A- and W-subtype contact binaries are found as 4.4 and 4.6 Gyr, respectively. From kinematic studies, these ages are given as 4.5 and 4.4 Gyr, respectively. We also compute orbital properties of A-subtype contact binaries at the time of the first overflow. Initial angular momentum of these binaries is computed by comparing them with the well-known detached binaries. The angular momentum loss rate derived in the present study for the detached phase is in very good agreement with the semi-empirical rates available in the literature. In addition to the limitations on the initial masses of W UMa-type contact binaries, it is shown that the initial period of these binaries is less than about 4.45 d.

Y?ld?z, M.

2014-01-01

283

A Self-Occulting Accretion Disk in the SW Sex Star DW UMa  

E-print Network

We present the ultraviolet spectrum of the SW Sex star and nova-like variable DW UMa in an optical low state, as observed with the Space Telescope Imaging Spectrograph on board the Hubble Space Telescope (HST). The data are well described by a synthetic white dwarf (WD) spectrum with T_eff = 46,000 +/- 1000 K, log g = 7.60 +/- 0.15, v*sin(i) = 370 +/- 100 km/s and Z/Z_solar = 0.47 +/- 0.15. For this combination of T_eff and log g, WD models predict M_WD = 0.48 +/- 0.06 M_solar and R_WD = (1.27 +/- 0.18) * 10^9 cm. Combining the radius estimate with the normalization of the spectral fit, we obtain a distance estimate of d = 830 +/-150 pc. During our observations, DW UMa was approximately 3 magnitudes fainter in V than in the high state. A comparison of our low-state HST spectrum to a high-state spectrum obtained with the International Ultraviolet Explorer shows that the former is much bluer and has a higher continuum level shortward of 1450 A. Since DW UMa is an eclipsing system, this suggests that an optically thick accretion disk rim blocks our view of the WD primary in the high state. If self-occulting accretion disks are common among the SW Sex stars, we can account for (i) the preference for high-inclination systems within the class and (ii) their V-shaped continuum eclipses. Moreover, even though the emission lines produced by a self-obscured disk are generally still double-peaked, they are weaker and narrower than those produced by an unobscured disk. This may allow a secondary line emission mechanism to dominate and produce the single-peaked, optical lines that are a distinguishing characteristic of the SW Sex stars.

C. Knigge; K. S. Long; D. W. Hoard; P. Szkody; V. S. Dhillon

2000-08-01

284

TX UMa: new orbit, spin rotation and chemical composition of components  

NASA Astrophysics Data System (ADS)

High-resolution echelle spectra have been obtained of the semi-detached Algol-type eclipsing binary system, TX UMa with the high-resolution echelle spectrographs of the 1.8 m telescope at Bohyunsan Optical Astronomy Observatory in Korea and of the 2.0 m telescope of Peak Terskol Observatory in Russia. New accurate radial velocities of its components have been measured. With the new measurements, we have been able to infer an improved orbital solution and the masses of the components of the system. For the first time, we have measured the rotational velocity for the Roche lobe filling secondary component. We have concluded that it rotates synchronously, while the rotation of the mass-accreting primary component is 1.5 times faster than synchronous. TX UMa confirms the previous conclusion that the strong lines of the light elements (N, O, Mg) in the atmospheres of mass-accreting components in Algol-type systems are stronger and wider than in single stars of the same spectral class and luminosity. Stronger lines also imply higher elemental abundances than weak lines, but this can also be explained if the former have greater microturbulent velocities. We have suggested that such an excess enhancement of the strong lines may be explained in terms of a distended pseudo-atmosphere of the mass-accreting component, engendered by gas flowing in via the L1 Lagrange point. We have found the chemical abundances of 12 elements in the atmosphere of the primary component of TX UMa. Si and Ni were found to show significant deficiencies while the abundance measures of C varied (within the uncertainties of the model atmosphere parameters) from solar to noticeably deficient. Other elements, including He, have solar abundance. The abundances of the secondary component are likely solar, as its spectrum is represented well by a synthetic spectrum with solar abundance and Teff= 5500 K and log g = 3.3.

Glazunova, L. V.; Mkrtichian, D. E.; Rostopchin, S. I.

2011-08-01

285

X-Ray Spectral Analysis of SU UMa Type Dwarf Novae Observed with Rosat  

NASA Astrophysics Data System (ADS)

X-ay spectral parameters were determined for eight SU UMa type Dwarf Novae observed with the ROSAT PSPC. The raw data were fitted with various spectral models and the best fit spectral models are found to be that of Raymond-Smith and Thermal Bremsstrahlung. The best fit temperatures were estimated to be between kT ~ 1.1 - 1.8 keV while the Column Densities were found to be between NH ~ 2.4 × 1020 - 4.1 × 1020 cm-2. The estimated 0.1 - 2.4 keV fluxes were in the range of log FX = -13 to -11 ergs cm-2 s-1. FX/FUV and FX/Fopt rates were calculated to be between ~ 0.09 and ~ 0.37. This shows that most of the energy is radiated in the Optical and Ultraviolet band from the accretion disk in the quiescent state. Many of the SU UMa type Dwarf Novae show an Ultraviolet lag in their outburst spectrum, the Coronal Siphon Flow Model of Meyer and Meyer-Hofmeister may explain this phenomenon. This model proposes a corona at the boundary layer of a system when it is a quiescent state and suggests that some parts of the X-rays come from the corona. For these reasons, the equations of this model were applied to the results of the spectral analysis. Using this model, the mass accretion rates, the mass evaporation rates, and the radii of the coronas were calculated to be ~ 10-12.3 - 10-11.3 Msolar yr-1, ~ 10-6.5 - 10-5.5 g cm-2 s-1 and ~ 109.1 - 109.9 cm, respectively. The pressures in the coronas were less than ~ 1200 g cm-2 s-1 for (z) up to ~ 10 × 109 cm. The obtained values suggest that the Corona model can indeed operate in SU UMa type Dwarf Novae.

Gün, Gülnur Ýkis; Ercan, E. Nihal

286

School Budget Hold'em Facilitator's Guide  

ERIC Educational Resources Information Center

"School Budget Hold'em" is a game designed to help school districts rethink their budgeting process. It evolved out of Education Resource Strategies' (ERS) experience working with large urban districts around the country. "School Budget Hold'em" offers a completely new approach--one that can turn the budgeting process into a long-term visioning…

Education Resource Strategies, 2012

2012-01-01

287

Fully distributed EM for very large datasets  

Microsoft Academic Search

In EM and related algorithms, E-step compu- tations distribute easily, because data items are independent given parameters. For very large data sets, however, even storing all of the parameters in a single node for the M- step can be impractical. We present a frame- work that fully distributes the entire EM pro- cedure. Each node interacts only with pa- rameters

Jason Wolfe; Aria Haghighi; Dan Klein

2008-01-01

288

LANSIM and its applications to distributed EMS  

SciTech Connect

Distributed energy management systems (EMS) open up a host of alternative design options. Simulation plays an important role in evaluating performance and in comparing alternative designs. Currently all the proposed distributed EMSs are local area network (LAN)-based. To illustrate the application of LANSIM, comparisons are made with different distributed EMS configurations, different LAN technologies (Ethernet and FDDI), and different Ethernet implementations.

Lun, S.M.; Lo, T.; Wu, F.; Murphy, L. [Univ. of California, Berkeley, CA (United States). Dept. of Electrical Engineering and Computer Sciences; Sen, A. [ABB Systems Control, Santa Clara, CA (USD)

1996-08-01

289

CCD Photometric Study of the Puzzling W UMa-type Binary TZ Boo  

NASA Astrophysics Data System (ADS)

The puzzling W-UMa type binary TZ Boo has been monitored at the University of Patras, Observatory from March to July 2010. Photometric solutions were determined through an analysis of the complete BVRI light curves with PHOEBE (Wilson-Devinney code) and published spectroscopic data. This low mass ratio binary turns out to be a deep overcontact system with f = 52.5% of A-subtype. A conservative spot model has been applied to fit the particular features of light curves. Based on our 7 new light minimum times and all others compiled from the literature over 70 years, we studied the orbital period from the O-C curve.

Christopoulou, P.-E.; Papageorgiou, A.; Chrysopoulos, I.

2012-04-01

290

Em que medida devem ser privados, em que medida devem ser pblicos o conhecimento e a informao?  

E-print Network

Em que medida devem ser privados, em que medida devem ser públicos o conhecimento e a informação? 1 Transparências com licença Creative Commons Em que medida devem ser privados, em que medida devem ser públicos o as alternativas? codexKonstanz #12;Em que medida devem ser privados, em que medida devem ser públicos o

Kuhlen, Rainer

291

ABORDAGEM DA SEXUALIDADE HUMANA EM LIVRO DIDÁTICO DE CIÊNCIAS - DESVELANDO OS BASTIDORES DE UMA PROPOSTA. APPROACH OF HUMAN SEXUALITY IN SCIENCE TEXBOOKS - REVEALING THE BACKSTAGE OF A PROPOSAL  

Microsoft Academic Search

In this article, teachers with a long classroom militancy, describe the process and challenges to become authors of textbooks. After brief reflections on issues related to textbooks and curriculum, the authors show the background of the production process: studies, research, meetings and even internal conflicts and external pressures. They choose to highlight their approach in human sexuality and its interfaces

Margarida Carvalho de Santana; Mônica de Cássia; Vieira Waldhelm

292

Clinical expression of obsessive-compulsive disorder in women with bipolar disorder Expressão clínica do transtorno obsessivo- compulsivo em uma amostra de mulheres com transtorno de humor bipolar  

Microsoft Academic Search

Abstract Abstract Abstract Abstract Objective: Objective: Objective: Objective: Objective: To study clinical and psychopathological features of obsessive-compulsive disorder (OCD) in women with bipolar disorder (BD). Methods: Methods: Methods: Methods: Methods: Fifteen outpatients with concurrent bipolar disorder I (80.0%) or II (20.0%) and obsessive-compulsive disorder were studied. Most of them (80.0%) sought treatment for bipolar disorder. They were ascertained by means

Cilly Klüger Issler; José Antonio de Mello; Renata Sayuri Tamada; Angela Maria Schwartzmann; Roseli Gedanke Shavitt; Eurípedes Constantino Miguel; Beny Lafer

2005-01-01

293

Intervenções educativas em asma na infância. Uma revisão analítica da literatura* Educational interventions for children with asthma: An analytical review of the literature  

Microsoft Academic Search

A review of the literature published from 1992 to 2002 was performed in order to evaluate educational interventions for asthmatics from 0 to 18 years of age and to identify characteristics related to the efficacy of such interventions. Various databases were used, and a manual search of the references found in the studies selected was conducted. Thirty-nine studies (including 27

LÍVIA FONSECA DA SILVA; CARVALHO DE AZEVEDO SANTANA; RITA DE CÁSSIA; SANTOS BASTOS; SOLANO DE FREITAS SOUZA

2005-01-01

294

ASPECTOS ERGONÔMICOS ENVOLVIDOS NA MANUTENÇÃO EM UMA EMPRESA DE BENEFICIAMENTO DE MÁRMORE E GRANITO ERGONOMIC ASPECTS IN THE MAINTENANCE OF A COMPANY OF MARBLE AND GRANITE IMPROVEMENT  

Microsoft Academic Search

This work presents a case study in a company of marble and granite improvement in Southern Espírito Santo State, with the aim of identifying the ergonomic aspects involved in the maintenance services. The used methodology was visits, observations and application of questionnaires. The results showed that the main ergonomic aspects involved in the main- tenance are related to work conditions

Armando Marques; Rui Francisco Martins Marçal; Aurélio Azevedo Barreto Neto

295

Changing Supercycle of the ER UMa-Type Star V1159 Ori  

E-print Network

We examined the VSNET light curve of the ER UMa-type star V1159 Ori. We detected a large variation of the supercycle (the interval between successive superoutbursts) between extremes of 44.6 and 53.3 d. The outburst activity was also found to decrease when the supercycle was long. The observed variation of the supercycle corresponds to a variation of ~40 % of the mass-transfer rate from the secondary star, totally unexpected for this class of objects. We also detected a hint of ~1800 d periodicity in the variation, whose period is close to what has been suggested for solar-type cycles for cataclysmic variables (CVs). If this periodicity is caused by the magnetic activity of the secondary star, this detection constitutes the first clear evidence of continuing magnetic activity in CV evolution, even after crossing the period gap. This activity may partly explain still poorly understood origins of the high mass-transfer rates in ER UMa-type stars.

Taichi Kato

2001-12-16

296

Long-Term Photometric Analysis of the Active W UMa-Type System TU Bootis  

NASA Astrophysics Data System (ADS)

We present multicolor light curves for the W UMa-type eclipsing binary TU Boo for two epochs separated by 22 years. An analysis of the O - C diagram indicates the earlier observations took place right in the middle of a major period change, thus allowing for a unique study on mass transfer and period changes in this W UMa-type system. We compute model fits to our light curves, along with the only other published set, using the Wilson-Devinney program, and find temporally correlated changes in the size of the secondary component with anomalies in the O - C diagram. We investigate the cause of these changes and find support for the existence of rapid, large-scale mass transfer between the components. We postulate that this interaction allows them to maintain nearly equal surface temperatures despite having achieved only marginal contact. We also find support for the evolutionary scenario in which TU Boo has undergone a mass ratio reversal in the past, due to large-scale mass transfer so that what is presently the secondary component of TU Boo is in an advanced evolutionary state, oversized due to a helium-enriched core, with a total system age of >=10 Gyr.

Coughlin, Jeffrey L.; Dale, Horace A., III; Williamon, Richard M.

2008-09-01

297

Long-term Photometric Analysis of the Active W UMa-type System TU Bootis  

NASA Astrophysics Data System (ADS)

We present multi-color light curves for the W UMa-type eclipsing binary TU Bootis for two epochs separated by approximately 22 years. An analysis of the O-C diagram indicates the earlier observations took place right in the middle of a major period change, thus allowing for a unique study on the evolution of this W Uma system. Model fits to our light curves, along with the only other published set, are computed using the Wilson-Devinney program, and reveal system changes correlated with the O-C diagram. The cause of these changes is investigated, and found to support thermal relaxation oscillation models in which the system is in a state of marginal contact. We find support for the evolutionary scenario in which TU Boo has undergone a mass ratio reversal in the past due to large-scale mass transfer. In this case, what is presently the secondary component of TU Boo is in an advanced evolutionary state, oversized due to a helium-enriched core.

Coughlin, Jeffrey; Dale, H.; Williamon, R.

2007-12-01

298

Variation in the orbital period of W UMa-type contact systems  

NASA Astrophysics Data System (ADS)

The secular variation in the orbital period Porb is studied as a function of the mass ratio q of the components in a sample of 73 contact systems of class W UMa constructed from a survey of current (1991-2003) published photometric and spectroscopic data. Almost all the W UMa-systems (>93% of this sample) are found to have a variation in their orbital periods Porb which alternates in sign independently of their division into A-and Wsubclasses. A statistical study of this sample in terms of the observed characteristics dPorb/dt and q showed that on the average the numbers of increases (35 systems) and decreases (33 systems) in the periods are the same, which indicates the existence of flows directed alternately from one component to the other and illustrates the cyclical character of the thermal oscillations. An analysis of the behavior of dPorb/dt as a function of the mass interval of the primary component yields a more accurate value for the mass ratio, q ? 0.4 ÷ 0.45 at which contact binaries are separated into A-and W-subclasses. No correlations were observed between the fill-out factor for the outer contact configuration, the total mass of the contact system, and the mass ratio of the components, on one hand, and the sign of the secular variation in the period. The physical properties and evolutionary features of these systems are discussed.

Dryomova, G. N.; Svechnikov, M. A.

2006-07-01

299

Models of the formation of the planets in the 47 UMa system  

E-print Network

Formation of planets in the 47 UMa system is followed in an evolving protoplanetary disk composed of gas and solids. The evolution of the disk is calculated from an early stage, when all solids, assumed to be high-temperature silicates, are in the dust form, to the stage when most solids are locked in planetesimals. The simulation of planetary evolution starts with a solid embryo of ~1 Earth mass, and proceeds according to the core accretion -- gas capture model. Orbital parameters are kept constant, and it is assumed that the environment of each planet is not perturbed by the second planet. It is found that conditions suitable for both planets to form within several Myr are easily created, and maintained throughout the formation time, in disks with $\\alpha \\approx 0.01$. In such disks, a planet of 2.6 Jupiter masses (the minimum for the inner planet of the 47 UMa system) may be formed at 2.1 AU from the star in \\~3 Myr, while a planet of 0.89 Jupiter masses (the minimum for the outer planet) may be formed at 3.95 AU from the star in about the same time. The formation of planets is possible as a result of a significant enhancement of the surface density of solids between 1.0 and 4.0 AU, which results from the evolution of a disk with an initially uniform gas-to-dust ratio of 167 and an initial radius of 40 AU.

Kacper Kornet; Peter Bodenheimer; Michal Rozyczka

2002-09-30

300

BVRI photometric and polarimetric studies of W UMa type eclipsing binary FO Hydra  

NASA Astrophysics Data System (ADS)

We present analysis of optical photometric and polarimetric observations of contact binary system FO Hydra (FO Hya). The computed period of the system is 0.469556 ± 0.000003 days. An O-C curve analysis indicates an increase in its period by 5.77 × 10-8 day yr-1. The photometric light curves are analyzed using Wilson-Devinney code (WD). The present analysis shows that FO Hya is a B-subtype of W UMa type contact binary. The radii and mass of primary and secondary components are found, respectively, to be R1 = 1.62 ± 0.03 R? and R2 = 0.91 ± 0.02 R?, and M1 = 1.31 ± 0.07 M? and M2 = 0.31 ± 0.11 M?. The light curve shape shows small asymmetries around the primary and secondary maxima. This may be due to the presence of dark spots on the components. The polarimetric observations yield average values of its polarization to be 0.18 ± 0.03, 0.15 ± 0.03, 0.17 ± 0.02 and 0.15 ± 0.02% in B, V, R and I bands, respectively. These values are appreciably lower than the typical polarization of W UMa type binaries. We have discussed the possible sources of the observed polarization but in order to arrive at definitive answer to this more phase locked observations are needed.

Prasad, Vinod; Pandey, J. C.; Patel, Manoj K.; Srivastava, D. C.

2013-04-01

301

NY Serpentis: SU UMa-type nova in the period gap with diversity of normal outbursts  

NASA Astrophysics Data System (ADS)

We present a photometric study of NY Ser, an in-the-gap SU UMa-type nova, in 2002 and 2013. We determined the duration of its superoutburst and the mean period of its superhump are 18 d and 0.10458 d, respectively. We detected in 2013 that NY Ser showed two distinct states separated by a superoutburst. A state of rather infrequent normal outbursts lasted at least 44 d before the superoutburst, and a state of frequent outbursts started immediately after the superoutburst and lasted at least 34 d. Unlike a typical SU UMa star with a bimodal distribution of outburst duration, NY Ser displayed a diversity of normal outbursts. In the state of infrequent outbursts, we detected a wide ˜ 12 d outburst accompanied by 0.098 d orbital modulation but without superhumps ever established in NY Ser. We classified this as a "wide normal outburst." The orbital period was dominant both in quiescence and during normal outbursts in this state. In the state of the most frequent normal outbursts, the 0.10465 d positive superhump period was dominant and coexisted with the orbital modulation. In 2002 we detected the normal outburst of "intermediate" 5-6 d duration that was also accompanied by orbital modulations.

Pavlenko, Elena P.; Kato, Taichi; Antonyuk, Oksana I.; Ohshima, Tomohito; Hambsch, Franz-Josef; Antonyuk, Kirill A.; Sosnovskij, Aleksei A.; Baklanov, Alex V.; Shugarov, Sergey Yu.; Pit, Nikolaj V.; Nakata, Chikako; Masi, Gianluca; Nakajima, Kazuhiro; Maehara, Hiroyuki; Dubovsky, Pavol A.; Kudzej, Igor; Andreev, Maksim V.; Kuznyetsova, Yuliana G.; Vasiliskov, Kirill A.

2014-12-01

302

PhenUMA: a tool for integrating the biomedical relationships among genes and diseases.  

PubMed

BackgroundSeveral types of genetic interactions in humans can be directly or indirectly associated with the causal effects of mutations. These interactions are usually based on their co-associations to biological processes, coexistence in cellular locations, coexpression in cell lines, physical interactions and so on. In addition, pathological processes can present similar phenotypes that have mutations either in the same genomic location or in different genomic regions. Therefore, integrative resources for all of these complex interactions can help us prioritize the relationships between genes and diseases that are most deserving to be studied by researchers and physicians.ResultsPhenUMA is a web application that displays biological networks using information from biomedical and biomolecular data repositories. One of its most innovative features is to combine the benefits of semantic similarity methods with the information taken from databases of genetic diseases and biological interactions. More specifically, this tool is useful in studying novel pathological relationships between functionally related genes, merging diseases into clusters that share specific phenotypes or finding diseases related to reported phenotypes.ConclusionsThis framework builds, analyzes and visualizes networks based on both functional and phenotypic relationships. The integration of this information helps in the discovery of alternative pathological roles of genes, biological functions and diseases. PhenUMA represents an advancement toward the use of new technologies for genomics and personalized medicine. PMID:25420641

Rodríguez-López, Rocío; Reyes-Palomares, Armando; Sánchez-Jiménez, Francisca; Medina, Miguel

2014-11-25

303

EM International, July 1994, Volume 2  

SciTech Connect

The Office of Environmental Management (EM) at the Department of Energy (DOE) is seeking out and leveraging foreign technology, data, and resources in keeping with EM`s mandate to protect public health and the environment through the safe and cost-effective remediation of the Department`s nuclear weapons sites. EM works closely with foreign governments, industry, and universities to obtain innovative environmental technologies, scientific and engineering expertise, and operations experience that will support EM`s objectives. Where appropriate, these international resources are used to manage the more urgent risks at our sites, secure a safe workplace, help build consensus on critical issues, and strengthen our technology development program. Through international agreements EM engages in cooperative exchange of information, technology, and individuals. Currently, we are managing agreements with a dozen countries in Europe, Latin America, and Asia. These agreements focus on environmental restoration, waste management, transportation of radioactive wastes, and decontamination and decommissioning. This publication contains the following articles: in situ remediation integrated program; in-situ characterization and inspection of tanks; multimedia environmental pollutant assessment system (MEPAS); LLNL wet oxidation -- AEA technology. Besides these articles, this publication covers: EU activities with Russia; technology transfer activities; and international organization activities.

Not Available

1994-10-01

304

Žem?s ?kio gamybos (ekologin?s ir ?prastin?s) ?taka dirvožemio savyb?ms ir žiemini? kvie?i? gr?d? kokybei.  

E-print Network

??Tyrimai atlikti 2008–2009 m. Lietuvos žem?s ?kio universiteto Agroekologijos centro ekologin?s gamybos ir mokomajame (chemizuota gamyba) ?kiuose. Darbo tikslas - ?vertinti ekologin?s žem?s ?kio gamybos… (more)

Užpurvis,; Edgaras

2010-01-01

305

XMM-Newton observations of the polars EV UMa, RX J1002-19 and RX J1007-20  

E-print Network

We present XMM-Newton data of three strongly magnetic cataclysmic variables (polars) EV UMa, RX J1002-19 and RX J1007-20. These include the polar with the shortest orbital period (EV UMa) and the polar with one of the highest magnetic field strengths (RX J1007-20). They exhibit a range of X-ray spectral characteristics which are consistent with their known magnetic field strength. We find that two of the systems show evidence for an absorption dip in soft X-rays. Their profiles are well defined, implying that the stream is highly collimated. We determine the mass transfer rate for the two systems with known distances. We determine that the mass of the white dwarf in EV UMa and RX J1007-20 is ~1Msun while in RX J1002-19 it is closer to ~0.5Msun.

Gavin Ramsay; Mark Cropper

2002-09-05

306

CCD photometric investigation of a W UMa-Type binary GSC 0763-0572  

NASA Astrophysics Data System (ADS)

A photometric solution of an A-type W UMa binary, GSC 0763-0572, is examined with a revised orbital period. The overcontact degree is found to be f = 40.66%, with a low mass ratio of q = 0.2554. The result demonstrates an unambiguous increase in the orbital period with a relative period change of ?P/P = +5.69 × 10-7 d yr-1. This indicates that GSC 0763-0572 is undergoing a process of mass transfer from the secondary component to the primary one with a rate of relative mass change of ?m1/m = +5.18 × 10-8 yr-1, for a conservative model of mass transfer. We find that GSC 0763-0572 might transform into a rapidly rotating star, if total spin angular momentum increases until it is greater than one-third of the orbital angular momentum, without breaking the contact configuration.

Kriwattanawong, Wichean; Pooseekheaw, Porntipa

2012-09-01

307

Light Curve Analysis for W UMa-Type Eclipsing Binary Star Systems  

NASA Astrophysics Data System (ADS)

We report results from summer 2006 in an ongoing study of eclipsing binary stars. Our investigations have focused on the measurement and interpretation of light curves for W UMa-type systems 44i Boötis and VW Cephei. These contact binaries have component stars of spectral type G, and revolve with periods of 6.43 and 6.67 hours. Dome automation and scripting capabilities introduced this summer have significantly reduced experimental uncertainties in our data. In support of previous findings we continue to observe an increase in the orbital period of 44i Boo at a rate of 10.4 µs/epoch or 14.2 ms/yr. Residuals computed after incorporating the increasing period suggest an underlying sinusoidal oscillation with a 61.5 year period and amplitude of 648 seconds. AAPT Member Thomas Olsen is sponsoring the lead presenter, SPS Member Scott Henderson, and the co-presenter, SPS Member Nick Peach.

Henderson, Scott; Peach, N.; Olsen, T.

2006-12-01

308

Mapping of surface activity on the W UMa-type system VW Cephei  

NASA Technical Reports Server (NTRS)

After multifilter photometry of the W UMa-type contact binary VW Cep (P = 6.67 hr; G5V + K0V) in 1986/87 revealed large asymmetries in the light curves believed to be caused by large, cool starspot regions on the surface of the larger stars, in Apr. 1987 it was observed with IUE to study the chromospheres and transition regions of the components. During one complete orbital cycle, three SWP and four LWP low dispersion spectra were obtained, including and then excluding the suspected active region. Phase dependent TR line emission strengths were found, most notably C IV, which is 50 percent stronger when the spot region is most visible. The results could be important because VW Cep represents an extreme case for studying stellar dynamo theory and observations can play a crucial role in the unterstanding of magnetic fields and activity cycles in rapidly rotating solar-like stars.

Bradstreet, David H.; Guinan, Edward F.

1988-01-01

309

On the Period Variation of the W UMa-type Contact Binary V502 Ophiuchi  

NASA Astrophysics Data System (ADS)

The variation in the orbital period of the W UMa type contact binary V502 Oph is analyzed. The orbital period exhibits a wavelike variation with a periodicity of 23.0 years and an amplitude of ?P = 1.24×10-6 days superimposed on secular decrease of dP/dt = 1.68×10-7 day per year. The long-term decrease may be accompanied by the contraction of the secondary at a rate of 83 m per year and a mass transfer rate from the primary to the secondary of 4.28×10-8Modot per year. The short-term oscillation may be explained by the presence of a third component. Orbital elements of the third body and its possible mass are presented.

Liu, Qing-Yao; Yang, Yu-Lan

2006-06-01

310

Multicolour high-speed photometry and H? spectroscopy of XY UMa  

NASA Astrophysics Data System (ADS)

BVRI photometry and H? -line spectroscopy of the short-period RS CVn-binary XY UMa are presented. The light curves as a whole as well as the two eclipse minima are asymmetric. The light level after the primary minimum is lower by about 0.04-0.05 mag than that after the secondary one. Two cool spots on the primary with sizes 20degr and 10degr , temperatures 4630 and 4330 K at middle latitudes reproduced well the distortion curve in all colours. The observed H? profile is quite wide and asymmetric at most the phases out of the eclipses. The radial velocity curve is sinusoidal with semiamplitude K1=120.7+/- 2.9 km/s. The corresponding mass function of the system is 0.082Msun . The phase behaviour of the H? -profile implies contribution of emission of the chromospheric regions above the photospheric spots.

Kjurkchieva, D.; Marchev, D.; Ogloza, W.

2000-02-01

311

Ultra-weak magnetic fields in Am stars: ? UMa and ? Leo  

NASA Astrophysics Data System (ADS)

An extremely weak circularly-polarized signature was recently discovered in spectral lines of the chemically peculiar Am star Sirius A (Petit et al. 2011). This signal was interpreted as a Zeeman signature related to a sub-gauss longitudinal magnetic field, constituting the first detection of a surface magnetic field in an Am star. We present here ultra-deep spectropolarimetric observations of two other bright Am stars, ? UMa and ? Leo, observed with the NARVAL spectropolarimeter. The line profiles of the two stars display circularly-polarized signatures similar in shape to the observations gathered for Sirius A. These new detections suggest that very weak magnetic fields may be present in the photospheres of a significant fraction of intermediate-mass stars, although the strongly asymmetric Zeeman signatures measured so far in Am stars (featuring a prominent positive lobe and no detected negative lobe) are not expected in the standard theory of the Zeeman effect.

Blazère, A.; Petit, P.; Lignières, F.; Aurière, M.; Böhm, T.; Wade, G.

2014-12-01

312

Sonification of Kepler Field SU UMa Cataclysmic Variable Stars V344 Lyr and V1504 Cyg  

NASA Technical Reports Server (NTRS)

Sonification is the conversion of quantitative data into sound. In this work we explain the methods used in the sonification of light curves provided by the Kepler instrument from Q2 through Q6 for the cataclysmic variable systems V344 Lyr and V1504 Cyg . Both systems are SU UMa stars showing dwarf nova outbursts and superoutbursts as well as positive and negative superhumps. Focused sonifications were done from average pulse shapes of each superhump, and separate sonifications of the full, residual light curves were done for both stars. The audio of these data reflected distinct patterns within the evolutions of supercycles and superhumps that matched pervious observations and proved to be effective aids in data analysis.

Tutchton, Roxanne M.; Wood, Matt A.; Still, Martin D.; Howell, Steve B.; Cannizzo, John K.; Smale, Alan P.

2012-01-01

313

Ultra weak magnetic fields in Am stars: Beta UMa and theta Leo  

E-print Network

An extremely weak circularly-polarized signature was recently discovered in spectral lines of the chemically peculiar Am star Sirius A (Petit et al. 2011). This signal was interpreted as a Zeeman signature related to a sub-gauss longitudinal magnetic field, constituting the first detection of a surface magnetic field in an Am star. We present here ultra-deep spectropolarimetric observations of two other bright Am stars, $\\beta$ UMa and $\\theta$ Leo, observed with the NARVAL spectropolarimeter. The line profiles of the two stars display circularly-polarized signatures similar in shape to the observations gathered for Sirius A. These new detections suggest that very weak magnetic fields may be present in the photospheres of a significant fraction of intermediate-mass stars, although the strongly asymmetric Zeeman signatures measured so far in Am stars (featuring a prominent positive lobe and no detected negative lobe) are not expected in the standard theory of the Zeeman effect.

Blazère, Aurore; Lignières, François; Aurière, Michel; Böhm, Torsten; Wade, Gregg

2014-01-01

314

EMS offshore. A new horizon for paramedics.  

PubMed

The difficulty in getting medical aid to offshore drilling platforms can be a source of life-threatening delays. Recently, some companies have charted new waters by actually stationing EMS crews on their rigs. PMID:10116023

Mallard, A S

1991-10-01

315

EMS Division Potential Benefits of Selected  

E-print Network

Engineers Journal, January 1998, p 107 2 D. Kuhlmann-Wilsdorf, "Metal Fiber Brushes", in Electrical Contacts coils are stationary; there are no rotating cold seals #12;EMS Division Advanced Homopolar Motor Concept

316

Revisão sistemática sobre obesidade em adolescentes brasileiros  

Microsoft Academic Search

Resumo - O propósito deste estudo foi revisar, de forma sistemática, a literatura nacional sobre a prevalência e fatores associados à obesidade em adolescentes. A busca foi realizada nas bases de dados Pubmed e Bireme, através dos descritores: \\

Rafael Miranda Tassitano; Maria Cecília Marinho Tenório; Pedro C Hallal

317

Kinematics of W UMa-type binaries and evidences on the two types of formation  

E-print Network

The kinematics of 129 W UMa binaries is studied and its implications on the contact binary evolution is discussed. The sample is found to be heterogeneous in the velocity space that kinematically younger and older contact binaries exist in the sample. Kinematically young (0.5 Gyr) sub-sample (MG) is formed by selecting the systems which are satisfying the kinematical criteria of moving groups. After removing the possible MG members and the systems which are known to be members of open clusters, the rest of the sample is called Field Contact Binaries (FCB). The FCB has further divided into four groups according to The orbital period ranges. Then a correlation has been found in the sense that shorter period less massive systems have larger velocity dispersions than the longer period more massive systems. Dispersions in the velocity space indicates 5.47 Gyr kinematical age for the FCB group. Comparing with the field chromospherically active binaries (CAB), presumably detached binary progenitors of the contact systems, the FCB appears to be 1.61 Gyr older. Assuming an equilibrium in the formation and destruction of CAB and W UMa systems in the Galaxy, this age difference is treated as empirically deduced lifetime of the contact stage. Since the kinematical ages of the four sub groups of FCB are much longer than the 1.61 Gyr lifetime of the contact stage, the pre-contact stages of FCB must dominantly be producing the large dispersions. The kinematically young (0.5 Gyr) MG group covers the same total mass, period and spectral ranges as the FCB. But, the very young age of this group does not leave enough room for pre-contact stages, thus it is most likely that those systems were formed in the beginning of the main-sequence or during the pre-main-sequence contraction phase.

S. Bilir; Y. Karatas; O. Demircan; Z. Eker

2004-11-11

318

Triple Co-Administration of Ivermectin, Albendazole and Praziquantel in Zanzibar: A Safety Study  

Microsoft Academic Search

Background: Public health interventions based on distribution of anthelminthic drugs against lymphatic filariasis (LF), onchocerciasis, soil-transmitted helminthiasis (STH) and schistosomiasis have been implemented separately to date. A better use of available resources might be facilitated by a more coordinated approach to control such infections, including the possibility of co-administering the three recommended anthelminthic drugs through a single, large-scale intervention. Methodology\\/Principal

Khalfan A. Mohammed; Hamad J. Haji; Albis-Francesco Gabrielli; Likezo Mubila; Gautam Biswas; Lester Chitsulo; Mark H. Bradley; Dirk Engels; Lorenzo Savioli; David H. Molyneux

2008-01-01

319

Efficacy of oxamniquine and praziquantel in the treatment of Schistosoma mansoni infection: a controlled trial  

Microsoft Academic Search

groups. Survival analysis (Kaplan-Meier) and the log-rank test were used to evaluate the efficacy of the treatments. Findings The sensitivity of stool examinations ranged from 88.9% to 94.4% when patients presented with >5000 S. mansoni eggs per gram of tissue (oogram); when the number of eggs dropped to <1000 eggs per gram, sensitivity was reduced (range, 22.7-34.0%). When cure was

M. L. A. Ferrari; P. M. Z. Coelho; C. M. F. Antunes; C. A. P. Tavares; A. S. da Cunha

320

77 FR 4225 - Oral Dosage Form New Animal Drugs; Milbemycin Oxime, Lufenuron, and Praziquantel  

Federal Register 2010, 2011, 2012, 2013

...control of various internal parasites in dogs. DATES: This rule is effective January...whipworm, and adult tapeworm infections in dogs and puppies 2 pounds of body weight or...Reserved] (d) Conditions of use--(1) Dogs--(i) Amount. 0.5 mg...

2012-01-27

321

77 FR 47511 - New Animal Drugs; Cephalexin; Fentanyl; Milbemycin Oxime and Praziquantel  

Federal Register 2010, 2011, 2012, 2013

...with Washington Ave., surgical procedures in Madison, WI 53703. dogs. 141-338............ Novartis Animal INTERCEPTOR SPECTRUM Original approval for New yes................ CE \\1\\ Health US, Inc., (milbemycin...

2012-08-09

322

21 CFR 520.1872 - Praziquantel, pyrantel pamoate, and febantel tablets.  

Code of Federal Regulations, 2011 CFR

...Taenia pisiformis, Echinococcus granulosus ); hookworms (Ancylostoma caninum, Uncinaria stenocephala ); ascarids (Toxocara canis, Toxascaris leonina ); and whipworms (Trichuris vulpis ) and for the removal and control of tapeworm...

2011-04-01

323

21 CFR 520.1872 - Praziquantel, pyrantel pamoate, and febantel tablets.  

Code of Federal Regulations, 2013 CFR

...Taenia pisiformis, Echinococcus granulosus ); hookworms (Ancylostoma caninum, Uncinaria stenocephala ); ascarids (Toxocara canis, Toxascaris leonina ); and whipworms (Trichuris vulpis ) and for the removal and control of tapeworm...

2013-04-01

324

21 CFR 520.1872 - Praziquantel, pyrantel pamoate, and febantel tablets.  

Code of Federal Regulations, 2012 CFR

...Taenia pisiformis, Echinococcus granulosus ); hookworms (Ancylostoma caninum, Uncinaria stenocephala ); ascarids (Toxocara canis, Toxascaris leonina ); and whipworms (Trichuris vulpis ) and for the removal and control of tapeworm...

2012-04-01

325

21 CFR 520.1872 - Praziquantel, pyrantel pamoate, and febantel tablets.  

...Taenia pisiformis, Echinococcus granulosus ); hookworms (Ancylostoma caninum, Uncinaria stenocephala ); ascarids (Toxocara canis, Toxascaris leonina ); and whipworms (Trichuris vulpis ) and for the removal and control of tapeworm...

2014-04-01

326

M em ory for Item s and M em ory for R elations in the Procedural/D eclarative M em ory Fram ew ork  

E-print Network

ever, as we hope to m ake clear here, progress on this front M E M O R Y , 1 99 7, 5 (1 /2 ), 1 31 ±17M em ory for Item s and M em ory for R elations in the Procedural/D eclarative M em ory Fram ew ork ard Eichenbaum Boston U niversity, U SA A m ajor area of research in m em ory and am nesia concerns

Poldrack, Russ

327

O MODO DE FAZER SAÚDE: A FISIOTERAPIA NA RESIDÊNCIA MULTIPROFISSIONAL EM SAÚDE DA FAMÍLIA EM UMA UNIDADE BÁSICA THE MODE OF PROMOTING HEALTH: PHYSICAL THERAPY IN THE MULTIPROFESSIONAL RESIDENCY IN FAMILY HEALTH IN THE BASIC UNIT  

Microsoft Academic Search

This present study brings the experience of the resident in physical therapy, inserted in a Family Health Unit (FHU), in the city of Londrina, with the purpose of describing the role of the physical therapy resident in the FHU and characterizing the users who received healthcare. Data were collected from dossiers and worksheets of 501 patients from April 2007 to

Cristhiane Yumi Yonamine; Celita Salmaso Trelha

328

Ubv(Ri)C Photometry of the Contact W Uma Binary Bd + 14?5016  

NASA Astrophysics Data System (ADS)

New UBV(RI)C observations and radial velocities of the W UMa-type system BD + 14?5016 were collected. Changes of the properties of a hot spot, located on the surface of the primary component, have been noticed.

Karska, A.; Mikolajewski, M.; Maciejewski, G.; Galan, C.; Ligeza, P.

2005-04-01

329

Feeding time strategies of the fringe-toed lizard, Uma inornata , during breeding and non-breeding seasons  

Microsoft Academic Search

I examined the foraging behavior during the breeding and non-breeding seasons, May and July 1986, of the fringe-toed lizard Uma inornata (Iguanidae). During the breeding season males differ from females in their diet and in their foraging time strategy, males exhibiting time minimization and females energy maximization. In May, plant associated foods were selectively eaten. Males concentrated on flowers, a

Richard D. Durtsche

1992-01-01

330

Large-Scale Climate Controls of Interior Alaska River Ice Breakup PETER A. BIENIEK AND UMA S. BHATT  

E-print Network

. The breakup of river ice can also lead to ice jams and flooding in spring (Beltaos 2008) and occurs whenLarge-Scale Climate Controls of Interior Alaska River Ice Breakup PETER A. BIENIEK AND UMA S. BHATT, it is important to understand the key mechanisms that control the timing of river ice breakup. The relationships

Bhatt, Uma

331

Charge, from EM fields only  

E-print Network

Consider the electric field E about an electron. Its source has been thought a substance called charge, enclosed within a small volume that defines the size of the electron. Scattering experiments find no size at all. Charge is useful, but mysterious. This study concludes that charge is not real. Useful, but not real. Absent real charge, the electric field must look to a different source. We know another electric field, vxB, not sourced by charge. A simple model of the electron, using EM fields only, has been found that generates an electric field vxB very like E. Gauss' law finds the model contains charge, but div vxB cannot find the charge density. The model contains a permanent magnetic flux quantum, configured as a dipole. The dipolar B fields spin around the symmetry axis, accounting for angular momentum. Spin stabilizes the magnetic flux quantum, and creates the vxB electric field. Stability in this model is dynamic. Energy is exchanged between the dipolar magnetic moment and an encircling toroidal displacement current, at the Compton frequency, mc^2/h = 1.24x10^20 Hz. The electric field undulates at this rate, instead of being static like E associated with charge. Absent any real charge, we have to abandon the notion that size of a charged particle is that of a small sack full of charge. The only electric field is vxB, and its source is not charge. What is the size of an electron? Coulomb scattering finds it point-like, but its spinning B fields extend to infinity.

R. L. Collins

2007-03-04

332

EMS adaptation for climate change  

NASA Astrophysics Data System (ADS)

The purpose of this study was to find an appropriate scenario of pre-hospital transportation of an emergency medical service (EMS) system for burdensome casualties resulting from extreme climate events. A case of natural catastrophic events in Taiwan, 88 wind-caused disasters, was reviewed and analyzed. A sequential-conveyance method was designed to shorten the casualty transportation time and to promote the efficiency of ambulance services. A proposed mobile emergency medical center was first constructed in a safe area, but nearby the disaster area. The Center consists of professional medical personnel who process the triage of incoming patients and take care of casualties with minor injuries. Ambulances in the Center were ready to sequentially convey the casualties with severer conditions to an assigned hospital that is distant from the disaster area for further treatment. The study suggests that if we could construct a spacious and well-equipped mobile emergency medical center, only a small portion of casualties would need to be transferred to distant hospitals. This would reduce the over-crowding problem in hospital ERs. First-line ambulances only reciprocated between the mobile emergency medical center and the disaster area, saving time and shortening the working distances. Second-line ambulances were highly regulated between the mobile emergency medical center and requested hospitals. The ambulance service of the sequential-conveyance method was found to be more efficient than the conventional method and was concluded to be more profitable and reasonable on paper in adapting to climate change. Therefore, additional practical work should be launched to collect more precise quantitative data.

Pan, C.; Chang, Y.; Wen, J.; Tsai, M.

2010-12-01

333

Structure and evolution of low-mass W UMa-type systems  

NASA Astrophysics Data System (ADS)

The structure and evolution of low-mass W UMa-type contact binaries are discussed by employing Eggleton's stellar evolution code. Assuming that these systems completely satisfy Roche geometry for contact binaries with every kind of mass ratio (0.02-1.0) we calculate the relative radii (R1,2/A, where R1,2 are the radii of both stars and A is the orbital separation) of both components of contact binaries with different contact depths between inner and outer Roche lobes. We obtain a radius grid of contact binaries and can ensure the surfaces of two components lying on an equipotential surface by interpolation using this radius grid when we follow the evolution of the contact binaries. There are serious uncertainties concerning mainly the transfer of energy in these systems, i.e. it is unclear how and where the energy is transferred. We assume that the energy transfer takes place in different regions of the common envelope to investigate the effects of the region of energy transfer on the structure and evolution of contact binaries. We find that the region of energy transfer has a significant influence on the structure and evolution of contact binaries, and conclude that the energy transfer may occur in the outermost layers of the common convective envelope for W-type systems, and that this transfer takes place in the deeper layers of the common envelope for A-type systems. Meanwhile, if we assume that the energy transfer takes place in the outermost layers for our model with low total mass, and find that our model steadily evolves towards a system with a smaller mass ratio and a deeper envelope, suggesting that some A-type W UMa systems with low total mass could be considered as the later evolutionary stages of W-subtype systems, and that the surface temperature of the secondary exceeds that of the primary during the time when the primary expands rapidly, or the secondary contracts rapidly, suggesting that W-subtype systems may be caused by expansion of the primary, or by the contraction of the secondary.

Li, Lifang; Han, Zhanwen; Zhang, Fenghui

2004-06-01

334

Ternarity, Activity, and Evolutionary State of the W UMa-Type Binary UX Eridani  

NASA Astrophysics Data System (ADS)

Charge-coupled device photometric observations of the W UMa-type binary star UX Eridani are presented. Comparing the B light curve with that obtained by Binnendijk in 1964-1965, the variation of the light curve around the primary minimum was found. Photometric solutions of Binnendijk's and our light curves were derived by using the new version of the Wilson-Devinney program. Our solutions confirmed that UX Eri is a marginal W-type overcontact binary system with a very low degree of overcontact, f < 15%. The change of the light curve around the primary minimum was explained as the disappearance of a dark spot on the more massive component star. This suggests that UX Eri shows strong magnetic activity, which is in agreement with its having the highest X-ray flux among 57 W UMa-type binary stars studied by Stepien et al. The high level of magnetic activity was interpreted as the result of a shallow common convective envelope. Orbital period changes were analyzed using several newly determined CCD times of light minimum together with others collected from the literature. A cyclic period change (T = 45.3 yr) was found to be superimposed on a long-term increase (dP/dt = +7.7 × 10-8 days yr-1). The period oscillation and the existence of third light both confirm that UX Eri contains a tertiary component. Since no spectroscopic companion was found, it is estimated that the mass of the third body is M3 < 0.56 Modot. The tertiary component star is moving in an eccentric orbit (e' = 0.72) with an orbital inclination of i' > 44.5°. The tertiary component may have played an important role in the formation of the progenitor of UX Eri by transferring angular momentum during the Kozai oscillation. In that way, the detached progenitor could evolve into overcontact configuration via magnetic braking. It was found that the timescale of the period increase is close to the thermal timescale of the less massive component, which suggests that UX Eri is in an evolutionary state of thermally conservative mass transfer from the less massive component to the more massive one.

Qian, S.-B.; Yuan, J.-Z.; Xiang, F.-Y.; Soonthornthum, B.; Zhu, L.-Y.; He, J.-J.

2007-11-01

335

DEZ ANOS DE EXPERIÊNCIA DO COMITÊ DE ÉTICA EM PESQUISA DA SECRETARIA DE SAÚDE DO DISTRITO FEDERAL, BRASIL  

PubMed Central

O objetivo deste artigo é relatar a experiência do Comitê de Ética em Pesquisa da Secretaria de Estado de Saúde do Distrito Federal (CEP/SES/DF) Brasil, durante o período de 10 anos a partir de sua fundação. Trata-se de uma avaliação descritiva e documental, na modalidade estudo de caso, utilizando-se a totalidade de projetos protocolados no CEP/SES/DF (N° 052/08) nesse período. As pendências mais freqüentes dos projetos foram: termo de consentimento livre e esclarecido (30%), folha de rosto (25%), metodologia (20%), curriculum vitae (12%), planilha de orçamento (9%), outros (4%). O relato das atividades do CEP/SES/DF no período de 10 anos revelou, através de sua produtividade, a legitimidade do processo de análise ética dos protocolos visando à proteção dos participantes da pesquisa. PMID:19888441

Novaes, Maria Rita C. G.; Guilhem, Dirce; Lolas, Fernando

2009-01-01

336

Variable Stars in the Large Magellanic Cloud: Discovery of Extragalactic W UMa Binaries  

NASA Astrophysics Data System (ADS)

We observed a field in the disk of the LMC on two consecutive nights in search of rapid variable stars. We found two pulsating stars of type RRab and ? Scuti and four binary stars; among the latter we found one sdB or cataclysmic variable below the LMC blue main sequence and three very close binary systems on the main sequence. At least one of the main-sequence binaries, and possibly all three, are the first solar-type (W UMa-type) contact binaries to be detected in any extragalactic system and observed to obey the same MV=MV(logP, B-V) calibration as the Galactic systems. Given the selection effects due to small amplitudes at faint magnitudes, the frequency of such binaries in the disk of the LMC with its large spread in population ages is not inconsistent with that in the disk of our Galaxy and contrasts with the lack of binaries found in earlier observations of the much younger LMC cluster LW 55. Based on data obtained at Las Campanas Observatory, operated by the Carnegie Institution of Washington, during the University of Toronto time allocation.

Kaluzny, Janusz; Mochnacki, Stefan; Rucinski, Slavek M.

2006-01-01

337

The first CCD photometric study of the neglected W UMa-type binary PP Lacertae  

NASA Astrophysics Data System (ADS)

The first complete charge couple device (CCD) photometric light curve in V band of the neglected W UMa-type binary star, PP Lacertae, is presented. It is shown that the system is a complete eclipsing binary and belongs to W type according to Binnendijk's classification where the occultation minimum is much deep than the transit one. The light curve is symmetric and no day-to-day variation of the light curve was found. These properties enable good chance to determine photometric parameters of the binary system. Photometric solutions based on the complete light curve were derived with the 2003 version of the W-D code. It is suggested that PP Lacertae is a W-type overcontact binary system with a mass ratio of q = 2.3000(±0.0044) and a median degree of overcontact of f = 23.9%(±1.1%). The temperature of the less massive component is about 260 K higher than that of the more massive one. Our four CCD times of light minimum, including others collected from the literature, have been used for the period study. It is found that the period showed a small-amplitude cyclic oscillation with a period of 19.7 years and an amplitude of 0. d0058, which can be explained as the light-time effect of an unseen third body.

Qian, S.-B.; Zhu, L.-Y.; Boonruksar, S.

2005-10-01

338

V2213 Cyg is a New W Uma-Type System  

NASA Astrophysics Data System (ADS)

V2213 Cyg was discovered as a variable star by Pavlenko (1999) in 1998. We present our photometry of V2213 Cyg from 1998 2003 based on CCD observations with the K-380 Cassegrain telescope of CrAO and the 60 cm Zeiss telescope of SAI. Observations have been carried out mostly in R and sometimes in B and V Johnson system. The total amount of data is 2270 points, covering ˜50 nights. We classify this binary as a W UMa-type contact system. Using all data we determined the orbital period to be 0.350079 ± 0.000007 day. The mean brightness varies between R = 14.35 and 14.05. The mean 1999 2003 orbital light curve has two humps and a primary minimum (I), which is 0.04 mag brighter than the deeper secondary one (II). The mean humps have slightly different height. The difference between two individual maxima varies within 0.1 mag, which may indicate an activity of the components. The highest hump is an asymmetrical one: it has sort of a shoulder at phases 0.75 0.80, before entering the less deep primary minimum (phase 0.0). The system is rather reddened, its colour indices are: B-V ˜ 0.8 and V-R ˜ 0.7, and give a spectral class of V2213 Cyg earlier than K.

Pavlenko, Elena; Litvinchova, Anna

2005-04-01

339

Absolute and geometric parameters of the W UMa-type contact binary V404 Pegasi  

NASA Astrophysics Data System (ADS)

We present the results of our investigation of the geometrical and physical parameters of the W UMa-type binary V404 Peg from analysis of CCD (BV RI) light curves and radial velocity data. The photometric data were obtained during 2010 at Ankara University Observatory (AUO). Light and radial velocity observations were analyzed simultaneously by using the well-known Wilson-Devinney (2007 revision) code to obtain absolute and geometrical parameters. Our solution indicates that V404 Peg is an A-type overcontact binary with a mass ratio of q=0.243 and an overcontact degree of f=32.1 %. Combining our light curves with the radial velocity curves from Maciejewski & Ligeza (2004), we determined the absolute parameters of this system as follows: a=2.672 R?, M1=1.175 M_?, M_2=0.286 M_?, R1=1.346 R?, and R2=0.710 R?. Finally, we discuss the evolutionary condition of the system.

Gürol, B.; Terzio?lu, Z.; Gürsoytrak, S. H.; Gökay, G.; Derman, E.

2011-08-01

340

Photometric Study of AH Cancri, a W UMa-Type System in M67  

NASA Astrophysics Data System (ADS)

We present time-series CCD photometry of AH Cnc, a W UMa-type binary system in the old open cluster M67. Over 3500 measurements in two filters were recorded on 15 nights from 2001 to 2004. From the data, 17 new times of minima for the eclipsing binary were obtained, from which a new ephemeris was derived. The orbital period of the system is refined as 0.36045754 days. A photometric analysis for the obtained light curves is performed based on the Wilson-Devinney code. The photometric solutions reveal a totally eclipsing contact configuration for AH Cnc. The photometric mass ratio is determined to be 0.149+/-0.002. The masses and radii of the components are estimated as 1.21+/-0.08 Msolar and 1.36+/-0.03 Rsolar for the primary and 0.18+/-0.02 Msolar and 0.62+/-0.02 Rsolar for the secondary, respectively. The evolutionary status of the contact system is briefly discussed.

Zhang, X. B.; Zhang, R. X.; Deng, L.

2005-02-01

341

Possible solution to the problem of the extreme mass ratio W UMa-type binaries  

NASA Astrophysics Data System (ADS)

When the total angular momentum of a binary system is at a critical (minimum) value, a tidal instability occurs (Darwin's instability), eventually forcing the stars to merge into a single, rapidly rotating object. The instability sets in at some critical separation which in the case of contact binaries corresponds to a minimum mass ratio depending on dimensionless gyration radius k1. If one considers n = 3 polytrope (fully radiative primary with ?1 = 4/3), k21 = 0.075 and qmin ~ 0.085-0.095. There appears to be, however, some W UMa-type binaries with q values very close, if not below these theoretical limits, implying that primary in these systems is probably more centrally condensed. We try to solve the discrepancy between theory and observations by considering rotating polytropes. We show by deriving and solving a modified Lane-Emden equation for n = 3 polytrope that including the effects of rotation does increase the central concentration and could reduce qmin to as low as 0.070-0.074, more consistent with the observed population.

Arbutina, B.

2009-03-01

342

Kinematics of W UMa-type binaries and evidences on the two types of formation  

E-print Network

The kinematics of 129 W UMa binaries is studied and its implications on the contact binary evolution is discussed. The sample is found to be heterogeneous in the velocity space that kinematically younger and older contact binaries exist in the sample. Kinematically young (0.5 Gyr) sub-sample (MG) is formed by selecting the systems which are satisfying the kinematical criteria of moving groups. After removing the possible MG members and the systems which are known to be members of open clusters, the rest of the sample is called Field Contact Binaries (FCB). The FCB has further divided into four groups according to The orbital period ranges. Then a correlation has been found in the sense that shorter period less massive systems have larger velocity dispersions than the longer period more massive systems. Dispersions in the velocity space indicates 5.47 Gyr kinematical age for the FCB group. Comparing with the field chromospherically active binaries (CAB), presumably detached binary progenitors of the contact sy...

Bilir, S; Demircan, O; Eker, Z

2004-01-01

343

CCD Observations and Analysis of W UMA Type Binary SS ARIETIS  

NASA Astrophysics Data System (ADS)

The BVR CCD observations of W UMa-type eclipsing binary SS Arietis were made for ten nights from November 1996 to December 1996 at the Sobaeksan Astronomy Observatory. From the observed light curves, nine new times of minimum lights were derived from the Kwee and van Woerden's method. Improved light elements for this system were determined from these minimum lights with all the published minima. The analysis of the times of minima of SS Ari confirms that the orbital period of SS Ari has been suffering from a sinusoidal variation as the suggestions of other previous investigators (Kaluzny & Pojmanski 1984, Demircan & Selam 1993). The calculation shows that the cyclic period change has a period of about 56.3yrs with an amplitude of about 0.d052. The period variation has been discussed in terms of two potential mechanisms : 1) the light-time effect due to a hypothetical third body and 2) deformations in the convective envelope of a magnetically active component. The BVR light curves of SS Ari observed for about one month showed the existence of cycle to cycle light variations. Long-term light changes of SS Ari are discussed in terms of the period variation of the binary system.

Han, W.; Kim, Chun-Hwey; Lee, Jae Woo; Kim, Ho-Il; Lee, Woo-Baik

344

VizieR Online Data Catalog: HD 163151: a new W UMa type system (Rodriguez+ 1998)  

NASA Astrophysics Data System (ADS)

Table 2 contains 408 simultaneous measurements collected in each of the four uvby colours of the Stromgren photometric system for the W UMa system HD 163151. The data are magnitude differences (Du, Dv, Db, Dy, D(b-y), Dm1, Dc1) of the variable star minus comparison star in the standard system versus Heliocentric Julian Day. Tables 3, 4 and 5 are the same, but for H? (65 points), Johnson B data (212 points) and Johnson V data (355 points). The comparison star is HD 166095. The origin in time is the Julian Day 2449858. The observations were carried out (by E. Rodriguez, A. Claret, J.M. Garcia, F.M. Zerbi, R. Garrido, S. Martin, C. Akan, K. Luedeke, V. Keskin, C. Ibanoglu, S. Evren, Z. Tunca, R. Pekunlu, M. Paparo, J. Nuspl, K. Krisciunas and S.Y. Jiang) in 1995 during the course of a multisite campaign. The following telescopes were used: 90cm telescope of the Sierra Nevada Observatory, Spain (uvby-H? photometry); 50cm telescope at the Ege University Observatory, Turkey (BV-uvby); 50cm telescope at Piszkesteto mountain station, Konkoly Observatory, Hungary (BV); 50cm telescope at the Merate Observatory, Italy (V); 30cm telescope at Albuquerque, New Mexico, USA (V) and 15cm telescope at Mauna Kea, Hawaii, USA (V). (4 data files).

Rodríguez, E.; Claret, A.; García, J. M.; Zerbi, F. M.; Garrido, R.; Martín, S.; Akan, C.; Luedeke, K.; Keskin, V.; Ibanoglu, C.; Evren, S.; Tunca, Z.; Pekunlu, R.; Paparo, M.; Nuspl, J.; Krisciunas, K.; Jiang, S. Y.

1998-06-01

345

An Extensive Analysis of the Triple W UMa Type Binary FI Boo  

NASA Astrophysics Data System (ADS)

We present a detailed analysis of the interesting W UMa binary FI Boo in view of the spectroscopic signature of a third body through photometry, period variation, and a thorough investigation of solution uniqueness. We obtained new BVRcIc photometric data that, when combined with spectroscopic data, enable us to analyze the system FI Boo and determine its basic orbital and physical properties through PHOEBE, as well as the period variation by studying the times of the minima. This combined approach allows us to study the long-term period changes in the system for the first time in order to investigate the presence of a third body and to check extensively the solution uniqueness and the uncertainties of derived parameters. Our modeling indicates that FI Boo is a W-type moderate (f = 50.15% ± 8.10%) overcontact binary with component masses of M h = 0.40 ± 0.05 M ? and M c = 1.07 ± 0.05 M ?, temperatures of T h = 5746 ± 33 K and T c = 5420 ± 56 K, and a third body, which may play an important role in the formation and evolution. The results were tested by heuristic scanning and parameter kicking to provide the consistent and reliable set of parameters that was used to obtain the initial masses of the progenitors (1.71 ± 0.10 M ? and 0.63 ± 0.01 M ?, respectively). We also investigated the evolutionary status of massive components with several sets of widely used isochrones.

Christopoulou, P.-E.; Papageorgiou, A.

2013-12-01

346

Tour of the Electromagnetic Spectrum (EMS) Videos  

NSDL National Science Digital Library

These videos introduce middle- and high school-age learners to the electromagnetic spectrum. The product consists of 8 animations including an introduction to electromagnetic waves and one animation for each wavelength of the EM spectrum (Radio, Microwave, Infrared, Visible, Ultraviolet, X-Rays and Gamma Rays). Each wavelength of the EM spectrum offers a construct to illustrate and teach about NASA sensors, missions, and science. Emphasis is placed on relevant science, such as lunar exploration, and hot science topics, such as climate change. The examples and narrative for each wavelength animation build on the learners’ prior knowledge then introduces examples from NASA missions. These examples explore the use of spectral analysis and visualizations that help scientists make discoveries about the world around us using EM waves.

Troy Benesch

2009-01-01

347

EM-ONE : an architecture for reflective commonsense thinking  

E-print Network

This thesis describes EM-ONE, an architecture for commonsense thinking capable of reflective reasoning about situations involving physical, social, and mental dimensions. EM-ONE uses as its knowledge base a library of ...

Singh, Pushpinder, 1972-2006.

2005-01-01

348

ECE 341: Electromagnetic Fields I EM devices and systems  

E-print Network

in material media - Electromagnetic induction - Inductance - Magnetic energy Applications: - ElectronicsECE 341: Electromagnetic Fields I EM devices and systems - Can compute and analyze potentials compositions - Can evaluate capacitance, inductance, resistance, and conductance of EM structures - Understands

Schumacher, Russ

349

EM2: A Scalable Shared-Memory Multicore Architecture  

E-print Network

We introduce the Execution Migration Machine (EM2), a novel, scalable shared-memory architecture for large-scale multicores constrained by off-chip memory bandwidth. EM2 reduces cache miss rates, and consequently off-chip ...

Khan, Omer

2010-06-12

350

7 CFR 759.6 - EM to be made available.  

... 2014-01-01 2014-01-01 false EM to be made available. 759.6 Section 759...DESIGNATIONS AND NOTIFICATIONS § 759.6 EM to be made available. (a) For purposes of the EM Program under part 764, subpart I, of...

2014-01-01

351

7 CFR 759.6 - EM to be made available.  

Code of Federal Regulations, 2013 CFR

... 2013-01-01 2013-01-01 false EM to be made available. 759.6 Section 759...DESIGNATIONS AND NOTIFICATIONS § 759.6 EM to be made available. (a) For purposes of the EM Program under part 764, subpart I, of...

2013-01-01

352

7 CFR 1945.35 - Special EM loan training.  

Code of Federal Regulations, 2011 CFR

...2011-01-01 2009-01-01 true Special EM loan training. 1945.35 Section 1945...Assistance-General § 1945.35 Special EM loan training. (a) General...completed they will be well qualified to process EM loans without undue delay. The...

2011-01-01

353

7 CFR 1945.35 - Special EM loan training.  

Code of Federal Regulations, 2010 CFR

...2010-01-01 2009-01-01 true Special EM loan training. 1945.35 Section 1945...Assistance-General § 1945.35 Special EM loan training. (a) General...completed they will be well qualified to process EM loans without undue delay. The...

2010-01-01

354

7 CFR 1945.35 - Special EM loan training.  

Code of Federal Regulations, 2012 CFR

...2012-01-01 2012-01-01 false Special EM loan training. 1945.35 Section 1945...Assistance-General § 1945.35 Special EM loan training. (a) General...completed they will be well qualified to process EM loans without undue delay. The...

2012-01-01

355

Bayesian Gaussian Process Classification with the EM-EP Algorithm  

E-print Network

Bayesian Gaussian Process Classification with the EM-EP Algorithm Hyun-Chul Kim and Zoubin of hyperparameters to determine various aspects of the function. Recently, the expectation propagation (EP) approach an approximate EM algorithm, the EM-EP algorithm, to learn both the latent function and the hyperparameters

Ghahramani, Zoubin

356

On Convergence Properties of the EM Algorithm for Gaussian Mixtures  

Microsoft Academic Search

We build up the mathematical connection between the Expectation-Maximization (EM) algorithm and gradient-based approaches for maximum likelihood learning of finite gaussian mixtures. We show that the EM step in parameter space is obtained from the gradient via a projection matrix P, and we provide an explicit expression for the matrix. We then analyze the convergence of EM in terms of

Lei Xu; Michael I. Jordan

1996-01-01

357

First Photometric Investigation of the Newly Discovered W UMa-type Binary Star MR Com  

NASA Astrophysics Data System (ADS)

By analyzing multi-color light curves of the newly discovered W UMa-type binary, MR Com, we discovered that it is a shallow-contact binary with a degree of contact factor of f = 10.0% ± 2.1%. Photometric solutions reveal that MR Com is a W-type system with a mass ratio of q = 3.9 where the less massive component is about 90 K hotter than the more massive one. By investigating all of the available times of minimum light, we found that the general trend of the Observed-Calculated (O - C) curve shows a downward parabolic variation while it undergoes a cyclic variation with a small amplitude of 0.0031 days and a period of 10.1 yr. The downward parabolic change corresponds to a long-term decrease in the orbital period at a rate of \\dot{P}=-5.3\\times {10^{-7}} days yr-1 that may be caused by a combination of a mass transfer and an angular momentum loss (AML) via magnetic braking. Among the 16 shallow-contact systems with a decreasing orbital period, MR Com has the lowest mass ratio (e.g., 1/q = 0.26). The shallow-contact configuration, the low-mass ratio, and the long-term period decrease all suggest that systems similar to MR Com are on the AML-controlled stage of the evolutionary scheme proposed by Qian. They will oscillate around a critical mass ratio and evolve into a deep contact with a higher mass ratio. The small-amplitude cyclic change in the O - C curve was analyzed for the light-travel time effect via the presence of an extremely cool stellar companion.

Qian, S.-B.; Liu, N.-P.; Liao, W.-P.; He, J.-J.; Liu, L.; Zhu, L.-Y.; Wang, J.-J.; Zhao, E.-G.

2013-08-01

358

A New Photometric Investigation of the W UMa-Type Binary BI CVn  

NASA Astrophysics Data System (ADS)

New photometric observations and their investigation of the W UMa-type binary, BI CVn, are presented. The variations of the orbital period were analyzed based on 12 new determined times of light minimum together with the others compiled from the literature. It is discovered that the period of BI CVn shows a long-term period decrease at a rate of \\dot{P}=-1.51(± 0.12)× {10^{-7}} days year-1 while it undergoes a cyclic variation with a period of 27.0 years and an amplitude of 0fd0151. Photometric solutions determined with the Wilson-Devinney method suggest that BI CVn is a contact binary with a degree of contact of 18.0(±1.7)%. The asymmetry of the light curves was interpreted by the presence of dark spots on both components, and absolute parameters were determined by combining the photometric elements with the spectroscopic solutions given by Lu. The observed period decrease can be plausibly explained by a combination of the mass transfer from the primary to the secondary and angular momentum loss via magnetic braking. The cyclic period oscillation suggests that BI CVn is a triple system containing a tertiary component with a mass no less than 0.58 M sun in a 27.0 year orbit. As in the cases of the other contact binaries (e.g., AH Cnc, AP Leo, AD Cnc, and UX Eri), it is possible that this tertiary companion played an important role for the formation and evolution of the contact system by removing angular momentum from the central system via Kozai oscillation or a combination of Kozai cycle and tidal friction, which causes the eclipsing pair to have a short initial orbital period (e.g., P < 5d). In that case, can the initially detached system evolve into the present contact configuration via a combination of magnetic torques from stellar winds and a case A mass transfer?

Qian, S.-B.; He, J.-J.; Liu, L.; Zhu, L.-Y.; Liao, W. P.

2008-12-01

359

The Low-Mass Limit for Total Mass of W UMa-type Binaries  

NASA Astrophysics Data System (ADS)

The observations of W UMa type stars show a well-defined short-period limit of 0.22 d, which is equivalent to a lower mass limit of approximately 1 M_odot for the total binary mass. It is currently believed that cool contact binaries are formed from detached binaries losing angular momentum (AM) via a magnetized wind. Orbital evolution of detached binaries with various component masses was followed until the primary component reached the critical Roche surface and the Roche lobe overflow (RLOF) began. It was assumed that the minimum initial, i.e., ZAMS, orbital period of such binaries is equal to 2 d and that the components lose AM just as single stars. According to the mass-dependent formula for AM loss rate of single stars, derived in this paper, the AM loss time scale increases substantially with decreasing stellar mass. The formula was applied to binaries with the initial primary component masses between 1.0 M_odot and 0.6 M_odot and two values of mass ratio q=1 and 0.5. Detailed calculations show that the time needed to reach RLOF by a 1 M_odot primary is of the order of 7.5 Gyr, but it increases to more than 13 Gyr for a binary with an initial primary mass of 0.7 M_odot. Binaries with less massive primaries have not yet had time to reach RLOF even within the age of the Universe. This sets a lower mass limit for the presently existing contact binaries at about 1.0 M_odot--1.2 M_odot, in a good agreement with observations.

Stepien, K.

2006-12-01

360

A Photometric Study of the W UMa-Type Contact Binary RZ Com  

NASA Astrophysics Data System (ADS)

We present results of CCD photometric observations of the short-period W UMa-type contact binary system, RZ Com. The light curve of the binary has changed from W-subtype to A-subtype from 1998 to 2003, then back to W-subtype in 2004. An analysis was carried out using the 2003 version of the Wilson-Devinney code. It is confirmed that RZ Com is a low-degree, overcontact f = 20.1% (+/-7.4%) binary system with a high inclination of i = 81.°40 (+/-0.°40), and a mass ratio q = 2.351 (+/-0.031). Combining four newly determined times of light minimum with others in the literature, the variations in orbital period is examined. A small-amplitude oscillation (A=0.0065d), with a period of 41.5 year, is discovered superimposed on a long-term increase at rate dP/dt = +3.97×10-8d yr-1. The period oscillation can be explained either by the light-time effect due to the presence of an unseen third body, or by cycles of magnetic activity on the components. Combining our photometric solution with the spectroscopic elements obtained by Mclean & Hilditch, the absolute dimensions of RZ Com are: M1 = 1.14 (+/-0.19)Modot, M2 = 0.50 (+/-0.09)Modot, R1 = 1.12 (+/-0.01)Rodot, R2 = 0.78 (+/-0.01)Rodot and A = 2.41 (+/-0.02)Rodot.

He, Jia-Jia; Qian, Sheng-Bang

2008-08-01

361

Infrasonic harmonic tremor and degassing bursts from Halema'uma'u Crater, Kilauea Volcano, Hawaii  

USGS Publications Warehouse

The formation, evolution, collapse, and subsequent resurrection of a vent within Halema'uma'u Crater, Kilauea Volcano, produced energetic and varied degassing signals recorded by a nearby infrasound array between 2008 and early 2009. After 25 years of quiescence, a vent-clearing explosive burst on 19 March 2008 produced a clear, complex acoustic signal. Near-continuous harmonic infrasonic tremor followed this burst until 4 December 2008, when a period of decreased degassing occurred. The tremor spectra suggest volume oscillation and reverberation of a shallow gas-filled cavity beneath the vent. The dominant tremor peak can be sustained through Helmholtz oscillations of the cavity, while the secondary tremor peak and overtones are interpreted assuming acoustic resonance. The dominant tremor frequency matches the oscillation frequency of the gas emanating from the vent observed by video. Tremor spectra and power are also correlated with cavity geometry and dynamics, with the cavity depth estimated at ~219 m and volume ~3 x 106 m3 in November 2008. Over 21 varied degassing bursts were observed with extended burst durations and frequency content consistent with a transient release of gas exciting the cavity into resonance. Correlation of infrasound with seismicity suggests an open system connecting the atmosphere to the seismic excitation process at depth. Numerous degassing bursts produced very long period (0.03-0.1 Hz) infrasound, the first recorded at Kilauea, indicative of long-duration atmospheric accelerations. Kilauea infrasound appears controlled by the exsolution of gas from the magma, and the interaction of this gas with the conduits and cavities confining it.

Fee, David; Garcés, Milton; Patrick, Matt; Chouet, Bernard; Dawson, Phil; Swanson, Don

2010-01-01

362

The First Photometric Investigation of the Neglected W-UMa-type Binary Star UZ CMi  

NASA Astrophysics Data System (ADS)

UZ CMi was a W-UMa-type binary star found more than 80 years ago. However, it has been neglected in photometric investigations. Here, the first complete light curves in the B, V, R, and I bands are presented and analyzed using the Wilson and Devinney method. It is discovered that UZ CMi is a contact binary (f = 38.4(± 2.3)%) with a mass ratio of 0.45. The derived orbital inclination (i = 87°) indicates that it is a total eclipsing binary, which suggests that the determined parameters are reliable. By using 17 new eclipse times together with those collected from the literature, we found that the general trend of the observed-calculated (O - C) curve shows an upward parabolic variation that corresponds to a long-term increase in the orbital period at a rate of \\dot{P}=+4.1× {10^{-8}} days yr-1. The continuous increase may be caused by a mass transfer from the less massive component to the more massive one. This suggests that UZ CMi is in the thermal relaxation oscillation controlled stage of the evolutionary scheme proposed by Qian. UZ CMi will oscillate around a critical mass ratio and the contact configuration cannot be broken. After the upward parabolic change was removed, the (O - C)2 curve of the photoelectric and charge-coupled device data revealed a cyclic variation with a small amplitude of 0.0026 days and a period of 21.1 yr. The cyclic change was analyzed for the light-travel time effect via the presence of an extremely cool stellar companion.

Qian, S.-B.; Li, K.; Liao, W.-P.; Liu, L.; Zhu, L.-Y.; He, J.-J.; Wang, J.-J.; Zhao, E.-G.

2013-04-01

363

FIRST PHOTOMETRIC INVESTIGATION OF THE NEWLY DISCOVERED W UMa-TYPE BINARY STAR MR Com  

SciTech Connect

By analyzing multi-color light curves of the newly discovered W UMa-type binary, MR Com, we discovered that it is a shallow-contact binary with a degree of contact factor of f = 10.0% {+-} 2.1%. Photometric solutions reveal that MR Com is a W-type system with a mass ratio of q = 3.9 where the less massive component is about 90 K hotter than the more massive one. By investigating all of the available times of minimum light, we found that the general trend of the Observed-Calculated (O - C) curve shows a downward parabolic variation while it undergoes a cyclic variation with a small amplitude of 0.0031 days and a period of 10.1 yr. The downward parabolic change corresponds to a long-term decrease in the orbital period at a rate of P-dot = -5.3 x 10{sup -7} days yr{sup -1} that may be caused by a combination of a mass transfer and an angular momentum loss (AML) via magnetic braking. Among the 16 shallow-contact systems with a decreasing orbital period, MR Com has the lowest mass ratio (e.g., 1/q = 0.26). The shallow-contact configuration, the low-mass ratio, and the long-term period decrease all suggest that systems similar to MR Com are on the AML-controlled stage of the evolutionary scheme proposed by Qian. They will oscillate around a critical mass ratio and evolve into a deep contact with a higher mass ratio. The small-amplitude cyclic change in the O - C curve was analyzed for the light-travel time effect via the presence of an extremely cool stellar companion.

Qian, S.-B.; Liu, N.-P.; Liao, W.-P.; He, J.-J.; Liu, L.; Zhu, L.-Y.; Wang, J.-J.; Zhao, E.-G., E-mail: qsb@ynao.ac.cn [Yunnan Observatories, Chinese Academy of Sciences (CAS), P.O. Box 110, 650011 Kunming (China)

2013-08-01

364

Physical parameters and dynamical properties of the multiple system ? UMa (ADS 7114)  

NASA Astrophysics Data System (ADS)

We analyze the physical parameters, orbital elements, and dynamic stability of the multiple system ? UMa (HD 76644 = ADS 7114). We have used the positions from the WDS catalog and our own observations on the 6-m telescope of the Special Astrophysical Observatory of the Russian Academy of Sciences and the 1.5-m Russian-Turkish Telescope (Antalya, Turkey). We have obtained more precise orbital parameters of the subsystems, and spectral types, absolute magnitudes, and masses of the components. The primary has Sp = F0 V-IV, M = 1.7 ± 0.1 M ?, T eff = 7260 ± 70 K, and log g = 4.30 ± 0.07. The companion in the close A a subsystem is most likely a white dwarf with a mass of approximately 1.0 ± 0.3 M ?. The spectral types and masses of the components in the BC subsystem are M3V, M4V and 0.35 ± 0.05 M ?, 0.30 ± 0.05 M ?, respectively. The total mass is 3.4 ± 0.4 M ?. The A a subsystem probably has an orbital period of 4470d = 12.2y and an eccentricity of approximately 0.6. The outer subsystem seems to have a period of approximately 2084 yrs and an eccentricity of approximately 0.9. We have carried out simulations using the stability criteria and shown that for all possible variations in the component parameters, the multiple system is unstable on a time scale of less than 106 years with a probability exceeding 0.98. Possible reasons for this instability are discussed.

Zhuchkov, R. Ya.; Malogolovets, E. V.; Kiyaeva, O. V.; Orlov, V. V.; Bikmaev, I. F.; Balega, Yu. Yu.

2012-07-01

365

Photometric Analysis of the Recently Discovered W UMa Star NR Camelopardalis: Period Change and Spot Migration  

NASA Astrophysics Data System (ADS)

NR Cam is a short period (P=0.26 days) eclipsing binary of the W UMa type that was relatively recently discovered in the ROTSE1 data of the Northern Sky Variability Survey (NSVS) and was originally listed in the New Catalog of Suspected Variable Stars (NSV) with the identifier NSV 3754. Here we present the first known detailed study of NR Cam, which includes multi-band light curves, color curves, and a photometric orbital solution. NR Cam exhibits a strong O'Connell effect that can be attributed to magnetically induced spot activity on one of the components. Absolute photometry was performed in B and V at the Kutztown University Observatory in 2013 October and November and complementary high precision differential light curves were obtained in BVRI at the same time, as part of the KELT follow-up network, at Brigham Young University's West Mountain Observatory, Swarthmore College's Peter Van de Kamp Observatory, and the University of Louisville's Moore Observatory. After the B-V color curves were used to approximate the stellar surface temperatures and spot locations, the Wilson-Devinney code was employed with a differential corrections routine to determine the most likely stellar properties and orbital parameters. Our solution indicates that the two stars are in contact, sharing a common envelope, and their surface temperatures are approximately 4500 K and 4200 K. The inclination of the orbit was determined to be 68.0 (±0.6) degrees. When compared with the NSVS data, we find that the orbital period of NR Cam has changed over the past decade and that the strength of the O'Connell effect, and the associated spot activity, has also varied significantly.

Shoup, Jenae; Reed, Phillip A.; Joner, Michael D.; Jensen, Eric L. N.; Collins, Karen A; Pepper, Joshua

2014-06-01

366

BVRI Photometric Analysis of the W UMa Binary, V428, in the field of NGC188  

NASA Astrophysics Data System (ADS)

V428 is a faint 15th magnitude binary observed in a study of the open cluster NGC188. However, its distance from the core of the cluster might exclude its membership. Its light curve was classified as a short period EB type eclipsing binary with a period of 0.3079 d and amplitude of ~0.7 mags in all curves. V428 was observed as a part of our student/professional collaborative studies of interacting binaries from data taken from Dark Sky Observatory of Appalachian State University, North Carolina. The difference in component temperatures is some DT =180 K and its fill-out is 35%. This undoubtedly has a semi-extreme mass ratio (q) otherwise its fill-out might dictate a smaller ?T. A brief, 2.5 year period study gives, as expected, a constant period, P=0.3076789 d. Five times of minimum light were calculated, 3 primary and 2 secondary eclipses from our present observations:HJD I = 2456598.6746±0.0007, 2456599.5990±0.0014, 2456600.8292±0.0013HJD II = 2456598.8299±0.0026, 2456599.7548±0.0025.The improved linear ephemeris is:JD Hel MinI = 2456599.5990(±0.0010) + 0.30767885(±0.00000043)d X E (1)More monitoring is needed to determine its true orbital evolution. The inclination, 80º is not quite enough to produce total eclipses, so a q-search was performed. Our best solution gives a q=0.4. A cool spot was modeled on the primary component to take care of the light curve asymmetries. It is a K-type W UMa contact binary.

Samec, Ronald G.; Maloney, David Edward; Clark, Jeremy; Caton, Daniel B.; Faulkner, Danny R.

2015-01-01

367

UBVRI Observations, Analysis and Spectra of the Mature W UMa Contact Binary, V444 And  

NASA Astrophysics Data System (ADS)

We present the first precision UBVRI light curves, synthetic light curve solution, a period study and spectra for the V444 Andromedae, an FO V contact W UMa binary. Observations were taken at Lowell Observatory with the 0.81-m reflector from 28 through 30 September 2012 and the spectra at Dominion Astrophysical Observatory’s (DAO) with the 1.8m telescope on 22 July 2013 at a resolution of 60 Å/mm. We determined three times of minimum light from these observations, JD Hel Min I = 2456199.0239±0.0011, 2456199.9616± 0.0015 and JD Hel Min II = 2456198.7907±0.0005. From our period study we determined an improved linear ephemeris, J.D. Hel Min I = 2456199.9618±0.0003d + 0.46877942±0.00000005×E The period has been stable over the past 9.6 years 7500 orbits). After an extensive mass ratio-search, the lowest residual mass ratio was found to be 0.48. Our final Wilson-Devinney Program computation determined that the system is an A-type W U Ma contact binary with a fill-out of nearly 51%. Despite its temperature (7200-7300 K), two magnetic spots were found on the primary component, a 10 degree radius equatorial dark spot, T-factor=0.88 and a 23 degree radius near polar hot spot, T-factor=1.10. The component temperature difference is only ~80K. These parameters tell us that the V444 And is a mature solar type binary.

Shebs, Travis; Samec, R. G.; Monroe, S.; Faulkner, D. R.; Robb, R. M.; Van Hamme, W. V.; Chamberlain, H.

2014-01-01

368

THE FIRST PHOTOMETRIC INVESTIGATION OF THE NEGLECTED W-UMa-TYPE BINARY STAR UZ CMi  

SciTech Connect

UZ CMi was a W-UMa-type binary star found more than 80 years ago. However, it has been neglected in photometric investigations. Here, the first complete light curves in the B, V, R, and I bands are presented and analyzed using the Wilson and Devinney method. It is discovered that UZ CMi is a contact binary (f = 38.4({+-} 2.3)%) with a mass ratio of 0.45. The derived orbital inclination (i = 87 Degree-Sign ) indicates that it is a total eclipsing binary, which suggests that the determined parameters are reliable. By using 17 new eclipse times together with those collected from the literature, we found that the general trend of the observed-calculated (O - C) curve shows an upward parabolic variation that corresponds to a long-term increase in the orbital period at a rate of P-dot = +4.1 x 10{sup -8} days yr{sup -1}. The continuous increase may be caused by a mass transfer from the less massive component to the more massive one. This suggests that UZ CMi is in the thermal relaxation oscillation controlled stage of the evolutionary scheme proposed by Qian. UZ CMi will oscillate around a critical mass ratio and the contact configuration cannot be broken. After the upward parabolic change was removed, the (O - C){sub 2} curve of the photoelectric and charge-coupled device data revealed a cyclic variation with a small amplitude of 0.0026 days and a period of 21.1 yr. The cyclic change was analyzed for the light-travel time effect via the presence of an extremely cool stellar companion.

Qian, S.-B.; Li, K.; Liao, W.-P.; Liu, L.; Zhu, L.-Y.; He, J.-J.; Wang, J.-J.; Zhao, E.-G., E-mail: qsb@ynao.ac.cn [National Astronomical Observatories/Yunnan Observatory, Chinese Academy of Sciences (CAS), P.O. Box 110, 650011 Kunming (China)

2013-04-15

369

The first five years of K?lauea’s summit eruption in Halema‘uma‘u Crater, 2008–2013  

USGS Publications Warehouse

The eruption in Halema‘uma‘u Crater that began in March 2008 is the longest summit eruption of K?lauea Volcano, on the Island of Hawai‘i, since 1924. From the time the eruption began, the new "Overlook crater" inside Halema‘uma‘u has exhibited fluctuating lava lake activity, occasional small explosive events, and a persistent gas plume. The beautiful nighttime glow impresses and thrills visitors in Hawai‘i Volcanoes National Park, but the continuous emission of sulfur dioxide gas produces "vog" (volcanic smog) that can severely affect communities and local agriculture downwind. U.S. Geological Survey scientists continue to closely monitor the eruption and assess ongoing hazards.

Patrick, Matthew R.; Orr, Tim; Sutton, Andrew J.; Elias, Tamar; Swanson, Don

2013-01-01

370

Light curve solutions of six eclipsing binaries at the lower limit of periods of the W UMa stars  

E-print Network

Photometric observations in V and I bands of six eclipsing binaries at the lower limit of the orbital periods of W UMa stars are presented. Three of them are newly discovered eclipsing systems. The light curve solutions revealed that all short-period targets were contact or overcontact binaries and added new six binaries to the family of short-period systems with estimated parameters. Four binaries have equal in size components and mass ratio near 1. The phase variability of the V-I colors of all targets may be explained by lower temperatures of their back surfaces than those of their side surfaces. Five systems revealed O'Connell effect that was reproduced by cool spots on the side surfaces of their primary components. The light curves of V1067 Her in 2011 and 2012 were fitted by diametrically opposite spots. The applying of the criteria for subdivision of the W UMa stars to our targets led to ambiguous results.

Kjurkchieva, Diana P; Ibryamov, Sunay I

2015-01-01

371

A Structural EM Algorithm for Phylogenetic Inference  

Microsoft Academic Search

A central task in the study of molecular evolution is the reconstruction of a phylogenetic tree from sequences of current-day taxa. The most established approach to tree reconstruction is maximum likelihood (ML) analysis. Unfortunately, searching for the maximum likelihood phylogenetic tree is computationally prohibitive for large data sets. In this paper, we describe a new algorithm that uses Structural EM

Nir Friedman; Matan Ninio; Itsik Pe'er; Tal Pupko

2002-01-01

372

Network Emulation with NetEm  

Microsoft Academic Search

Many protocols and applications perform poorly when exposed to real life networks with delay and packet loss. Often, it is costly and dicult to reproduce Internet behavior in a controlled environment. There are tools avail- able for testing, but they are either expen- sive hardware solutions, proprietary software, or limited research projects. NetEm is a recent enhancement of the trac

Stephen Hemminger

373

Bolseiros em protesto. "Para a banca milhes,  

E-print Network

segunda vez a candida- tura a bolsa de doutoramento. Em 179 candidatos entraram 12. Ele era o 14.° e acha para os animais já houve dificuldades", diz. David Gomes e Ana Silva, de 23 e 24 anos, estão a começar

Instituto de Sistemas e Robotica

374

Mercury pollution in the Ems estuary  

NASA Astrophysics Data System (ADS)

From approximately 1960 to 1975 the Ems estuary received several tons of mercury per year from a chlor-alkali plant, a pesticide factory and some minor sources. The discharge has been reduced drastically from 1976 onwards. In 1975 and 1976 measurements were made on the distribution of mercury in the sediment. The horizontal distribution revealed a strong local enrichment of the sediment near the point of discharge. The vertical distribution was found to be in accordance with the local deposition rates. In the water phase no significant change in mercury content from 1975 to 1978/79 could be demonstrated. In 1978/79 a difference between Ems estuary and Dutch Wadden Sea was not significant. In 1978 mercury contents of eelpout Zoarces viviparus in the Ems estuary were about twice as high as in the Wadden Sea. In the Ems estuary a decrease of these contents was found between 1974/75 and 1978. A similar decline in the Wadden Sea may be related to a decreased mercury discharge by the River Rhine.

Essink, K.

1980-03-01

375

de Ps-Graduao em Enfermagem  

E-print Network

/data expedição CPF Nome da mãe/pai Estado civil E-mail Endereço residencial #12;Programa de Pós-Graduação em Dirigir-se ao Banco do Brasil e fazer um depósito para a Agência: 14532 Conta �nica do Tesouro Nacional

Floeter, Sergio Ricardo

376

Efficient Scanning for EM Based Target Localization  

E-print Network

of the time. 1 Introduction Focused Ion Beam Scanning Electron Microscopes (FIB-SEM) and their ability Image Fig. 1. FIB-SEM Scanning Process. The microscope repeatedly scans the surface of a sample blockEfficient Scanning for EM Based Target Localization Raphael Sznitman, Aurelien Lucchi, Natasa

Fua, Pascal

377

EM-dissertations completed in 2007  

E-print Network

theme: Computational and Experimental Mechanics Sensing, Monitoring and Control of Laser Based Welding-90-9022179-3 EM research theme: Computational and Experimental Mechanics Thermomechanical fatigue failure;Sensor-guided robotic laser welding Graaf, M.W. de Advisor: Prof.dr.ir. J. Meijer; prof.dr.ir. J

Franssen, Michael

378

College of Engineering EM Engineering Mechanics  

E-print Network

College of Engineering EM Engineering Mechanics KEY: # = new course * = course changed = course; bending of beams; combined loading of members; buckling of columns. Prereq: Registration in the College.Kinematics:cartesianandpolarcoordinatesystems;normalandtangentialcomponents;translatingand rotating reference frames. Kinetics of particles and rigid bodies: laws of motion; work and energy; impulse

MacAdam, Keith

379

ESPÉCIES DO GÊNERO Eimeria (APICOMPLEXA: EIMERIIDAE) EM TAMANDUÁS-BANDEIRA (Myrmecophaga tridactyla LINNAEUS, 1758) EM CATIVEIRO  

Microsoft Academic Search

1 ABSTRACT:- FREITAS, F.L. DA C.; ALMEIDA, K. DE S.; ZANETTI, A.S.; NASCIMENTO, A.A. DO; MACHADO, C. R.; MACHADO, R.Z. (Species of the genus Eimeria (Apicomplexa: Eimeriidae) in giant anteaters (Myrmecophaga tridactyla Linnaeus, 1758) in captivity). Espécies do gênero Eimeria (Apicomplexa: Eimeriidae) em Tamanduás-bandeira (Myrmecophaga tridactyla Linnaeus, 1758) em cativeiro. Revista Brasileira de Parasitologia Veterinária, v. 15, n. 1, p.

FAGNER LUIZ DA C. FREITAS; ANDRÉ S. ZANETTI; CÉLIO R. MACHADO; ROSANGELA Z. MACHADO

380

BUSCA LOCAL PARA POS-PROCESSAMENTO EM RESULTADOS DE OTIMIZAC~AO MULTI-OBJETIVO EM REDES DE FILAS  

E-print Network

BUSCA LOCAL PARA P´OS-PROCESSAMENTO EM RESULTADOS DE OTIMIZA¸C~AO MULTI-OBJETIVO EM REDES DE FILAS otimiza¸c~ao de redes de filas finitas, a capacidade total do sistema em ´areas de espera deve ser a menor algoritmo simulated annealing foi desenvolvido, especialmente para redes de filas finitas, produzindo solu

Cruz, Frederico

381

Detection of the white dwarf and the secondary star in the new SU UMa dwarf nova HS 2219+1824  

Microsoft Academic Search

We report the discovery of a new, non-eclipsing SU UMa-type dwarf nova, HS 2219+1824. Photometry obtained in quiescence (V≈17.5) reveals a double-humped light curve from which we derive an orbital period of ~=86.2 min. Additional photometry obtained during a superoutburst reaching V~=12.0 clearly shows superhumps with a period of ~=89.05 min. The optical spectrum contains double-peaked Balmer and He I

P. Rodríguez-Gil; B. T. Gänsicke; H.-J. Hagen; T. R. Marsh; E. T. Harlaftis; S. Kitsionas; D. Engels

2005-01-01

382

The Latin Music Database: Uma Base de Dados Para a Classificac~ao Automatica de G^eneros Musicais  

E-print Network

The Latin Music Database: Uma Base de Dados Para a Classificac¸~ao Autom´atica de G^eneros Musicais Carlos N. Silla Jr.1 , Celso A. A. Kaestner2 , Alessandro L. Koerich1 1 Pontif´icia Universidade Cat@utfpr.edu.br, alekoe@ppgia.pucpr.br Abstract. In this paper we present the Latin Music Database, a novel database

Kent, University of

383

Frmions ultra-frios em redes ticas  

E-print Network

Férmions ultra-frios em redes óticas Thereza C de L Paiva Colóquio Interinstitucional CBPF - IMPA - UFF - UFRJ 18 de abril de 2012 #12;Átomos ultrafrios armadilhados Bósons e férmions Redes óticas;Redes óticasRedes óticas #12;Redes óticas Potencial confinante + Potencial periódico + #12;Dimensão 3D

Liu, I-Shih

384

Transportes em Revista.com Pas: Portugal  

E-print Network

Comentar artigo Imprimir PDF Enviar a um amigo 09 -10 -2012 Toyota aposta no hidrogénio para ve ículos Plug-in em Paris 21 -08 -2012 Toyota lan ça novo Auris com motoriza ção híbrida 20 -08 -2012 MAN Toyota Veículos híbridos Estatísticas deste artigo Passageiros & Mobilidade voltar Os utilizadores

Instituto de Sistemas e Robotica

385

TandEM: Titan and Enceladus mission  

Microsoft Academic Search

TandEM was proposed as an L-class (large) mission in response to ESA’s Cosmic Vision 2015–2025 Call, and accepted for further\\u000a studies, with the goal of exploring Titan and Enceladus. The mission concept is to perform in situ investigations of two worlds\\u000a tied together by location and properties, whose remarkable natures have been partly revealed by the ongoing Cassini–Huygens\\u000a mission. These

A. Coustenis; S. K. Atreya; T. Balint; R. H. Brown; M. K. Dougherty; F. Ferri; M. Fulchignoni; D. Gautier; R. A. Gowen; C. A. Griffith; L. I. Gurvits; R. Jaumann; Y. Langevin; M. R. Leese; J. I. Lunine; C. P. McKay; X. Moussas; I. Müller-Wodarg; F. Neubauer; T. C. Owen; F. Raulin; E. C. Sittler; F. Sohl; C. Sotin; G. Tobie; T. Tokano; E. P. Turtle; J.-E. Wahlund; J. H. Waite; K. H. Baines; J. Blamont; A. J. Coates; I. Dandouras; T. Krimigis; E. Lellouch; R. D. Lorenz; A. Morse; C. C. Porco; M. Hirtzig; J. Saur; T. Spilker; J. C. Zarnecki; E. Choi; N. Achilleos; R. Amils; P. Annan; D. H. Atkinson; Y. Bénilan; C. Bertucci; B. Bézard; G. L. Bjoraker; M. Blanc; L. Boireau; J. Bouman; M. T. Capria; E. Chassefière; P. Coll; M. Combes; J. F. Cooper; A. Coradini; F. Crary; T. Cravens; I. A. Daglis; E. de Angelis; C. de Bergh; I. de Pater; C. Dunford; G. Durry; O. Dutuit; D. Fairbrother; F. M. Flasar; A. D. Fortes; R. Frampton; M. Fujimoto; M. Galand; O. Grasset; M. Grott; T. Haltigin; A. Herique; F. Hersant; H. Hussmann; W. Ip; R. Johnson; E. Kallio; S. Kempf; M. Knapmeyer; W. Kofman; R. Koop; T. Kostiuk; N. Krupp; M. Küppers; H. Lammer; L.-M. Lara; P. Lavvas; S. Le Mouélic; S. Lebonnois; S. Ledvina; J. Li; T. A. Livengood; R. M. Lopes; J.-J. Lopez-Moreno; D. Luz; P. R. Mahaffy; U. Mall; J. Martinez-Frias; B. Marty; T. McCord; C. Menor Salvan; A. Milillo; D. G. Mitchell; R. Modolo; O. Mousis; M. Nakamura; C. D. Neish; C. A. Nixon; D. Nna Mvondo; G. Orton; M. Paetzold; J. Pitman; S. Pogrebenko; W. Pollard; O. Prieto-Ballesteros; P. Rannou; K. Reh; L. Richter; F. T. Robb; R. Rodrigo; S. Rodriguez; P. Romani; M. Ruiz Bermejo; E. T. Sarris; P. Schenk; B. Schmitt; N. Schmitz; D. Schulze-Makuch; K. Schwingenschuh; A. Selig; B. Sicardy; L. Soderblom; L. J. Spilker; D. Stam; A. Steele; K. Stephan; D. F. Strobel; K. Szego; C. Szopa; R. Thissen; M. G. Tomasko; D. Toublanc; H. Vali; I. Vardavas; V. Vuitton; R. A. West; R. Yelle; E. F. Young

2009-01-01

386

TandEM: Titan and Enceladus mission  

USGS Publications Warehouse

TandEM was proposed as an L-class (large) mission in response to ESA's Cosmic Vision 2015-2025 Call, and accepted for further studies, with the goal of exploring Titan and Enceladus. The mission concept is to perform in situ investigations of two worlds tied together by location and properties, whose remarkable natures have been partly revealed by the ongoing Cassini-Huygens mission. These bodies still hold mysteries requiring a complete exploration using a variety of vehicles and instruments. TandEM is an ambitious mission because its targets are two of the most exciting and challenging bodies in the Solar System. It is designed to build on but exceed the scientific and technological accomplishments of the Cassini-Huygens mission, exploring Titan and Enceladus in ways that are not currently possible (full close-up and in situ coverage over long periods of time). In the current mission architecture, TandEM proposes to deliver two medium-sized spacecraft to the Saturnian system. One spacecraft would be an orbiter with a large host of instruments which would perform several Enceladus flybys and deliver penetrators to its surface before going into a dedicated orbit around Titan alone, while the other spacecraft would carry the Titan in situ investigation components, i.e. a hot-air balloon (Montgolfi??re) and possibly several landing probes to be delivered through the atmosphere. ?? Springer Science + Business Media B.V. 2008.

Coustenis, A.; Atreya, S.K.; Balint, T.; Brown, R.H.; Dougherty, M.K.; Ferri, F.; Fulchignoni, M.; Gautier, D.; Gowen, R.A.; Griffith, C.A.; Gurvits, L.I.; Jaumann, R.; Langevin, Y.; Leese, M.R.; Lunine, J.I.; McKay, C.P.; Moussas, X.; Muller-Wodarg, I.; Neubauer, F.; Owen, T.C.; Raulin, F.; Sittler, E.C.; Sohl, F.; Sotin, C.; Tobie, G.; Tokano, T.; Turtle, E.P.; Wahlund, J.-E.; Waite, J.H.; Baines, K.H.; Blamont, J.; Coates, A.J.; Dandouras, I.; Krimigis, T.; Lellouch, E.; Lorenz, R.D.; Morse, A.; Porco, C.C.; Hirtzig, M.; Saur, J.; Spilker, T.; Zarnecki, J.C.; Choi, E.; Achilleos, N.; Amils, R.; Annan, P.; Atkinson, D.H.; Benilan, Y.; Bertucci, C.; Bezard, B.; Bjoraker, G.L.; Blanc, M.; Boireau, L.; Bouman, J.; Cabane, M.; Capria, M.T.; Chassefiere, E.; Coll, P.; Combes, M.; Cooper, J.F.; Coradini, A.; Crary, F.; Cravens, T.; Daglis, I.A.; de Angelis, E.; De Bergh, C.; de Pater, I.; Dunford, C.; Durry, G.; Dutuit, O.; Fairbrother, D.; Flasar, F.M.; Fortes, A.D.; Frampton, R.; Fujimoto, M.; Galand, M.; Grasset, O.; Grott, M.; Haltigin, T.; Herique, A.; Hersant, F.; Hussmann, H.; Ip, W.; Johnson, R.; Kallio, E.; Kempf, S.; Knapmeyer, M.; Kofman, W.; Koop, R.; Kostiuk, T.; Krupp, N.; Kuppers, M.; Lammer, H.; Lara, L.-M.; Lavvas, P.; Le, Mouelic S.; Lebonnois, S.; Ledvina, S.; Li, J.; Livengood, T.A.; Lopes, R.M.; Lopez-Moreno, J. -J.; Luz, D.; Mahaffy, P.R.; Mall, U.; Martinez-Frias, J.; Marty, B.; McCord, T.; Salvan, C.M.; Milillo, A.; Mitchell, D.G.; Modolo, R.; Mousis, O.; Nakamura, M.; Neish, C.D.; Nixon, C.A.; Mvondo, D.N.; Orton, G.; Paetzold, M.; Pitman, J.; Pogrebenko, S.; Pollard, W.; Prieto-Ballesteros, O.; Rannou, P.; Reh, K.; Richter, L.; Robb, F.T.; Rodrigo, R.; Rodriguez, S.; Romani, P.; Bermejo, M.R.; Sarris, E.T.; Schenk, P.; Schmitt, B.; Schmitz, N.; Schulze-Makuch, D.; Schwingenschuh, K.; Selig, A.; Sicardy, B.; Soderblom, L.; Spilker, L.J.; Stam, D.; Steele, A.; Stephan, K.; Strobel, D.F.; Szego, K.; Szopa

2009-01-01

387

TandEM: Titan and Enceladus mission  

NASA Astrophysics Data System (ADS)

TandEM was proposed as an L-class (large) mission in response to ESA’s Cosmic Vision 2015-2025 Call, and accepted for further studies, with the goal of exploring Titan and Enceladus. The mission concept is to perform in situ investigations of two worlds tied together by location and properties, whose remarkable natures have been partly revealed by the ongoing Cassini-Huygens mission. These bodies still hold mysteries requiring a complete exploration using a variety of vehicles and instruments. TandEM is an ambitious mission because its targets are two of the most exciting and challenging bodies in the Solar System. It is designed to build on but exceed the scientific and technological accomplishments of the Cassini-Huygens mission, exploring Titan and Enceladus in ways that are not currently possible (full close-up and in situ coverage over long periods of time). In the current mission architecture, TandEM proposes to deliver two medium-sized spacecraft to the Saturnian system. One spacecraft would be an orbiter with a large host of instruments which would perform several Enceladus flybys and deliver penetrators to its surface before going into a dedicated orbit around Titan alone, while the other spacecraft would carry the Titan in situ investigation components, i.e. a hot-air balloon (Montgolfière) and possibly several landing probes to be delivered through the atmosphere.

Coustenis, A.; Atreya, S. K.; Balint, T.; Brown, R. H.; Dougherty, M. K.; Ferri, F.; Fulchignoni, M.; Gautier, D.; Gowen, R. A.; Griffith, C. A.; Gurvits, L. I.; Jaumann, R.; Langevin, Y.; Leese, M. R.; Lunine, J. I.; McKay, C. P.; Moussas, X.; Müller-Wodarg, I.; Neubauer, F.; Owen, T. C.; Raulin, F.; Sittler, E. C.; Sohl, F.; Sotin, C.; Tobie, G.; Tokano, T.; Turtle, E. P.; Wahlund, J.-E.; Waite, J. H.; Baines, K. H.; Blamont, J.; Coates, A. J.; Dandouras, I.; Krimigis, T.; Lellouch, E.; Lorenz, R. D.; Morse, A.; Porco, C. C.; Hirtzig, M.; Saur, J.; Spilker, T.; Zarnecki, J. C.; Choi, E.; Achilleos, N.; Amils, R.; Annan, P.; Atkinson, D. H.; Bénilan, Y.; Bertucci, C.; Bézard, B.; Bjoraker, G. L.; Blanc, M.; Boireau, L.; Bouman, J.; Cabane, M.; Capria, M. T.; Chassefière, E.; Coll, P.; Combes, M.; Cooper, J. F.; Coradini, A.; Crary, F.; Cravens, T.; Daglis, I. A.; de Angelis, E.; de Bergh, C.; de Pater, I.; Dunford, C.; Durry, G.; Dutuit, O.; Fairbrother, D.; Flasar, F. M.; Fortes, A. D.; Frampton, R.; Fujimoto, M.; Galand, M.; Grasset, O.; Grott, M.; Haltigin, T.; Herique, A.; Hersant, F.; Hussmann, H.; Ip, W.; Johnson, R.; Kallio, E.; Kempf, S.; Knapmeyer, M.; Kofman, W.; Koop, R.; Kostiuk, T.; Krupp, N.; Küppers, M.; Lammer, H.; Lara, L.-M.; Lavvas, P.; Le Mouélic, S.; Lebonnois, S.; Ledvina, S.; Li, J.; Livengood, T. A.; Lopes, R. M.; Lopez-Moreno, J.-J.; Luz, D.; Mahaffy, P. R.; Mall, U.; Martinez-Frias, J.; Marty, B.; McCord, T.; Menor Salvan, C.; Milillo, A.; Mitchell, D. G.; Modolo, R.; Mousis, O.; Nakamura, M.; Neish, C. D.; Nixon, C. A.; Nna Mvondo, D.; Orton, G.; Paetzold, M.; Pitman, J.; Pogrebenko, S.; Pollard, W.; Prieto-Ballesteros, O.; Rannou, P.; Reh, K.; Richter, L.; Robb, F. T.; Rodrigo, R.; Rodriguez, S.; Romani, P.; Ruiz Bermejo, M.; Sarris, E. T.; Schenk, P.; Schmitt, B.; Schmitz, N.; Schulze-Makuch, D.; Schwingenschuh, K.; Selig, A.; Sicardy, B.; Soderblom, L.; Spilker, L. J.; Stam, D.; Steele, A.; Stephan, K.; Strobel, D. F.; Szego, K.; Szopa, C.; Thissen, R.; Tomasko, M. G.; Toublanc, D.; Vali, H.; Vardavas, I.; Vuitton, V.; West, R. A.; Yelle, R.; Young, E. F.

2009-03-01

388

Gastos Públicos com Pessoal: Uma Análise de Emprego e Salário no Setor Público Brasileiro nos Anos 90  

Microsoft Academic Search

Nesse artigo, mediante o uso das PNADs de 1992 a 2001 examinamos, em relação ao setor privado, a dinâmica de emprego e salário no setor publico no período e mostramos algumas evidências preliminares de efeitos da introdução do Plano Real (1994) e da Lei de Responsabilidade Fiscal (1998). Igualmente examinamos a dinâmica do diferencial educacional entre o setor publico e

Siegfried Bender; Reynaldo Fernandes

2009-01-01

389

ESTUDO DE UMA OPERADORA LOGÍSTICA DA CADEIA DO FRIO SITUADA NO NORDESTE BRASILEIRO: O CASO TRU-LOGÍSTICA  

Microsoft Academic Search

A globalização impôs à grande maioria dos mercados, níveis de especialização focados na eficiência como condição indispensável para sobrevivência. O surgimento desse novo cenário trouxe em seu arcabouço a necessidade de sinergia entre todas as áreas existentes na empresa. As áreas de marketing precisavam estar inteiradas da capacidade de vendas no respectivo departamento, que por sua vez, precisavam ter conhecimento

Fabio De Oliveira Medeiros; Luiz Andrea Favero; Lucinaldo De Sousa E Silva; Rejane Andrea Deiga Ferreira

2008-01-01

390

Mass Flux of Tephra Sampled Frequently During the Ongoing Halema`uma`u Eruption (Invited)  

NASA Astrophysics Data System (ADS)

The ongoing summit eruption of Kilauea provides an unparalleled opportunity to track, almost daily, the production of tephra. The eruption began on 19 March 2008, and tephra has been erupted every day since then to the end of August 2009. Most of the time, tephra is ejected quasi-continuously from the vent accompanied by a light gray to white gas plume, occasionally broken by a more vigorous pulse (“brown plume”) richer in ejecta. In early April 2008, an array of 10 plastic buckets was placed within 400 m of the new vent in Halema`uma`u down the prevailing NE wind direction. The configuration of the array, spanning an area of about 73,000 m2, has not changed since then. Buckets are emptied frequently, initially every day and, since summer 2008, on all weekdays. The contents are dried and weighed, and an “average network accumulation rate” is calculated in g/m2/hour. In addition, componentry analyses are made of the >0.5-mm size fraction from a bucket near the vent, in order to categorize the tephra into juvenile and lithic fractions. To estimate the total mass of tephra ejected from the vent for a given collection, we first drew isomass contours for several daily collections and plotted isomass versus square root of area to obtain the total mass of the deposit. From this, we developed an empirical multiplication factor that allows us to estimate, within ~25 percent, the total ejected mass per day in kilograms from the total collected mass in grams. The tephra is a mix of vitric and lithic pyroclasts, mostly ash in size. The vitric clasts, interpreted as juvenile, include Pele’s hair and tears, hollow spherules, dumbbells, pumice, and bits of coarsely vesicular glass. All these clasts were probably produced by weak spattering at the top of the lava column, which has rarely been seen. Especially since fall 2008, some vitric clasts are partly coated with secondary minerals or rock dust. We interpret such clasts as recycled, first erupted during spattering but falling back into the vent, where they resided until some later event lifted them to the crater rim. The daily juvenile mass flux, including recycled clasts but excluding 8 discrete explosive eruptions in 2008, ranged from 0 to 13,000 kg and was generally a few tens to a few hundreds of kilograms. We interpret the lithic clasts as derived from rock falls into the new vent and crater. Many have partial coatings of secondary minerals including anhydrite. The daily lithic mass flux varied from 1 to 6,900 kg. Much of the lithic material is perhaps better considered as rock-fall “dust” than as actual tephra. To date, about 400 tonnes of tephra have been ejected quasi-continuously, composing 18 percent of all tephra produced during the eruption. The rest resulted from the 8 discrete explosive eruptions, which ejected, in a few tens of seconds, masses more than ~7,000 kg (as high as ~ 800,000 kg). The total mass produced by these 8 eruptions is ~1,800 tonnes. The total mass of all tephra produced by the eruption is ~2,200 tonnes, with subequal amounts of juvenile and lithic components. The volume of lithic tephra (~1100 m3, assuming a deposit density of 1,000 kg/m3) is less than 1 percent of the volume of the new crater, currently ~130 m wide and 200 m deep. Clearly the crater has formed by collapse into underground void space.

Swanson, D.; Wooten, K.; Orr, T. R.

2009-12-01

391

Survey of period variations of superhumps in SU UMa-type dwarf novae. VI. The sixth year (2013-2014)  

NASA Astrophysics Data System (ADS)

Continuing the project undertaken by Kato et al. (2009), we collected times of superhump maxima for 56 SU UMa-type dwarf novae mainly observed during the 2013-2014 season and characterized these objects. We detected negative superhumps in VW Hyi and indicated that the low number of normal outbursts in some supercycles can be interpreted as a result of disk tilt. This finding, combined with the Kepler observation of V1504 Cyg and V344 Lyr, suggests that disk tilt is responsible for modulating the outburst pattern in SU UMa-type dwarf novae. We also studied the deeply eclipsing WZ Sge-type dwarf nova MASTER OT J005740.99+443101.5 and found evidence of a sharp eclipse during the phase of early superhumps. The profile can be reproduced by a combination of the eclipse of the axisymmetric disk and the uneclipsed light source of early superhumps. This finding shows the lack of evidence for a greatly enhanced hot spot during the early stage of WZ Sge-type outburst. We detected growing (stage A) superhumps in MN Dra and give a suggestion that some of SU UMa-type dwarf novae situated near the critical condition of tidal instability may show long-lasting stage A superhumps. The large negative period derivatives reported in such systems can be understood as a result of the combination of stage A and B superhumps. Two WZ Sge-type dwarf novae, AL Com and ASASSN-13ck, showed a long-lasting (plateau-type) rebrightening. In the early phase of their rebrightenings, both objects showed a precursor-like outburst, suggesting that the long-lasting rebrightening is triggered by a precursor outburst.

Kato, Taichi; Dubovsky, Pavol A.; Kudzej, Igor; Hambsch, Franz-Josef; Miller, Ian; Ohshima, Tomohito; Nakata, Chikako; Kawabata, Miho; Nishino, Hirochika; Masumoto, Kazunari; Mizoguchi, Sahori; Yamanaka, Masayuki; Matsumoto, Katsura; Sakai, Daisuke; Fukushima, Daiki; Matsuura, Minami; Bouno, Genki; Takenaka, Megumi; Nakagawa, Shinichi; Noguchi, Ryo; Iino, Eriko; Pickard, Roger D.; Maeda, Yutaka; Henden, Arne; Kasai, Kiyoshi; Kiyota, Seiichiro; Akazawa, Hidehiko; Imamura, Kazuyoshi; de Miguel, Enrique; Maehara, Hiroyuki; Monard, Berto; Pavlenko, Elena P.; Antonyuk, Kirill; Pit, Nikolaj; Antonyuk, Oksana I.; Baklanov, Aleksei V.; Ruiz, Javier; Richmond, Michael; Oksanen, Arto; Harlingten, Caisey; Shugarov, Sergey Yu.; Chochol, Drahomir; Masi, Gianluca; Nocentini, Francesca; Schmeer, Patrick; Bolt, Greg; Nelson, Peter; Ulowetz, Joseph; Sabo, Richard; Goff, William N.; Stein, William; Michel, Raúl; Dvorak, Shawn; Voloshina, Irina B.; Metlov, Vladimir; Katysheva, Natalia; Neustroev, Vitaly V.; Sjoberg, George; Littlefield, Colin; D?bski, Bart?omiej; Sowicka, Paulina; Klimaszewski, Marcin; Cury?o, Ma?gorzata; Morelle, Etienne; Curtis, Ivan A.; Iwamatsu, Hidetoshi; Butterworth, Neil D.; Andreev, Maksim V.; Parakhin, Nikolai; Sklyanov, Aleksandr; Shiokawa, Kazuhiko; Novák, Rudolf; Irsmambetova, Tat'yana R.; Itoh, Hiroshi; Ito, Yoshiharu; Hirosawa, Kenji; Denisenko, Denis; Kochanek, Christopher S.; Shappee, Benjamin; Stanek, Krzysztof Z.; Prieto, José L.; Itagaki, Koh-ichi; Stubbings, Rod; Ripero, Jose; Muyllaert, Eddy; Poyner, Gary

2014-10-01

392

VizieR Online Data Catalog: W UMa-type contact binaries ages and masses (Yildiz, 2014)  

NASA Astrophysics Data System (ADS)

Recently, our understanding of the origin of W UMa-type contact binaries has become clearer. Initial masses of their components were successfully estimated by Yildiz and Dogan using a new method mainly based on observational properties of overluminous secondary components. In this paper, we continue to discuss the results and make computations for age and orbital evolution of these binaries. It is shown that the secondary mass, according to its luminosity, also successfully predicts the observed radius. While the current mass of the primary component is determined by initial masses, the current secondary mass is also a function of initial angular momentum. We develop methods to compute the age of A- and W-subtype W UMa-type contact binaries in terms of initial masses and mass according to the luminosity of the secondaries. Comparisons of our results with the mean ages from kinematic properties of these binaries and data pertaining to contact binaries in open and globular clusters have increased our confidence on this method. The mean ages of both A- and W-subtype contact binaries are found as 4.4 and 4.6Gyr, respectively. From kinematic studies, these ages are given as 4.5 and 4.4Gyr, respectively. We also compute orbital properties of A-subtype contact binaries at the time of the first overflow. Initial angular momentum of these binaries is computed by comparing them with the well-known detached binaries. The angular momentum loss rate derived in the present study for the detached phase is in very good agreement with the semi-empirical rates available in the literature. In addition to the limitations on the initial masses of W UMa-type contact binaries, it is shown that the initial period of these binaries is less than about 4.45d. (1 data file).

Yildiz, M.

2014-11-01

393

Time Sequence Spectroscopy of AW UMa. The 518 nm Mg i Triplet Region Analyzed With Broadening Functions  

NASA Astrophysics Data System (ADS)

High-resolution spectroscopic observations of AW UMa, obtained on three consecutive nights with a median time resolution of 2.1 minutes, have been analyzed using the broadening function method in the spectral window of 22.75 nm around the 518 nm Mg i triplet region. Doppler images of the system reveal the presence of vigorous mass motions within the binary system; their presence puts into question the solid-body rotation assumption of the contact binary model. AW UMa appears to be a very tight, semi-detached binary; the mass transfer takes place from the more massive to the less massive component. The primary, a fast-rotating star with Vsin i=181.4+/- 2.5 km s-1, is covered with inhomogeneities: very slowly drifting spots and a dense network of ripples more closely participating in its rotation. The spectral lines of the primary show an additional broadening component (called the “pedestal”) that originates either in the equatorial regions, which rotate faster than the rest of the star by about 50 km s-1, or in an external disk-like structure. The secondary component appears to be smaller than predicted by the contact model. The radial velocity field around the secondary is dominated by accretion of matter transferred from (and possibly partly returned to) the primary component. The parameters of the binary are Asin i=2.73+/- 0.11 {{R}? } and {{M}1}{{sin }3}i=1.29+/- 0.15 {{M}? }, {{M}2}{{sin }3}i=0.128+/- 0.016 {{M}? }. The mass ratio, {{q}sp}={{M}2}/{{M}1}=0.099+/- 0.003, while still the most uncertain among the spectroscopic elements, is substantially different from the previous numerous and mutually consistent photometric investigations which were based on the contact model. It should be studied why photometry and spectroscopy give such discrepant results and whether AW UMa is an unusual object or if only very high-quality spectroscopy can reveal the true nature of W UMa-type binaries. Based on observations obtained at the Canada-France-Hawaii Telescope (CFHT), which is operated by the National Research Council of Canada, the Institut National des Sciences de l'Univers of the Centre National de la Recherche Scientique of France, and the University of Hawaii.

Rucinski, Slavek M.

2015-02-01

394

Complete-data spaces and generalized EM algorithms  

Microsoft Academic Search

Expectation-maximization (EM) algorithms have been applied extensively for computing maximum-likelihood and penalized-likelihood parameter estimates in signal processing applications. Intrinsic to each EM algorithm is a complete-data space (CDS)-a hypothetical set of random variables that is related to the parameters more naturally than the measurements are. The authors describe two generalizations of the EM paradigm: (i) allowing the relationship between the

J. A. Fessler; A. O. Hero

1993-01-01

395

Em18 and Em16, new serologic marker epitopes for alveolar echinococcosis in western blot analysis, are the only two epitopes recognized by commercially available weak positive (cut off) sera for Em2plus-ELISA.  

PubMed

The assay system for antibody responses against Em2, the most specific antigen for serodiagnosis of alveolar echinococcosis (AE), has been established by enzyme-linked immunosorbent assay (ELISA) but not by Western blot assay, since Em2 antigen is not protein but carbohydrate in nature. Recently we reported that previously undescribed protein epitopes, designated Em18 and Em16 due to their molecular weights, were good serologic markers for AE by Western blot analysis. It has been shown that Em18 and Em16 are the only two epitopes recognized by commercially available weak positive (cut off) sera for the Em2plus-ELISA. PMID:8583132

Ito, A; Osawa, Y; Nakao, M; Horii, T; Okamoto, M; Itoh, M; Yamashita, T

1995-12-01

396

2. HI PAR (ACQUISITION RADAR) TOWER AND ENLISTED MEN (EM) ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. HI PAR (ACQUISITION RADAR) TOWER AND ENLISTED MEN (EM) BARRACKS WITH RADAR ATTACHED. - Nike Hercules Missile Battery Summit Site, Battery Control Administration & Barracks Building, Anchorage, Anchorage, AK

397

Test beam performance of CDF plug upgrade EM calorimeter  

SciTech Connect

CDF Plug Upgrade(tile-fiber) EM Calorimeter performed resolution of 15%/{radical}E{circle_plus}0.7% with non-linearity less than 1% in a energy range of 5-180 GeV at Fermilab Test Beam. Transverse uniformity of inside-tower-response of the EM Calorimeter was 2.2% with 56 GeV positron, which was reduced to 1.0% with response map correction. We observed 300 photo electron/GeV in the EM Calorimeter. Ratios of EM Calorimeter response to positron beam to that to {sup 137}Cs Source was stable within 1% in the period of 8 months.

Fukui, Y. [National Lab. for High Energy Physics, Tsukuba, Ibaraki (Japan); CDF Upgrade Group

1998-01-01

398

Comparison of Observations and Analyses of 2009 and 2012 Light Curves for the Precontact W UMa Binary, V1001 Cassiopeia  

NASA Astrophysics Data System (ADS)

A 2012 follow up to the analysis of 2009 observations is presented for the very short period 0.43d) precontact WUMa Binary, V1001 Cassiopeia. Its short period, similar to the majority of W UMa’s, has a distinct EA light curve make it a very rare and interesting system for continuing photometric investigation. Previous photometric VRI standard magnitudes give a K4 spectral type (Samec 2012). Our solutions of light curves separated by some 3 years give approximately the same physical parameters. However the spots have radically changed, both temperature, area and position wise. Whereas only one dark spot was used to model the first curves, two hot spots are now needed. This affects the overall shape of the light curve, especially in the secondary eclipses in B and V. Additional eclipse timings show the orbital period is changing. We conclude that spots are very active on this solar type dwarf and that it may mimic its larger cousins, the RS CVn binaries.

Hill, Robert L.; Koenke, Samuel; Samec, Ronald G.; Faulkner, Danny R; Van Hamme, Walter V.

2014-06-01

399

Phase-resolved HST/STIS spectroscopy of the exposed white dwarf in the high-field polar AR UMa  

E-print Network

Phase-resolved HST/STIS ultraviolet spectroscopy of the high-field polar AR UMa confirms that the WD photospheric Ly alpha Zeeman features are formed in a magnetic field of ~200 MG. In addition to the Ly alpha pi and sigma+ components, we detect the forbidden hydrogen 1s0->2s0 transition, which becomes ``enabled'' in the presence of both strong magnetic and electric fields. Our attempt in fitting the overall optical+UV low state spectrum with single temperature magnetic WD models remains rather unsatisfactory, indicating either a shortcoming in the present models or a new physical process acting in AR UMa. As a result, our estimate of the WD temperature remains somewhat uncertain, Twd=20000+-5000K. We detect a broad emission bump centered at ~1445A and present throughout the entire binary orbit, and a second bump near ~1650A, which appears only near the inferior conjunction of the secondary star. These are suggestive of low harmonic cyclotron emission produced by low-level (M-dot~1e-13 Msun/yr) accretion onto...

Gänsicke, B T; Jordan, S; Szkody, P

2001-01-01

400

Survey of Period Variations of Superhumps in SU UMa-Type Dwarf Novae. VI: The Sixth Year (2013-2014)  

E-print Network

Continuing the project described by Kato et al. (2009, PASJ, 61, S395, arXiv:0905.1757), we collected times of superhump maxima for 56 SU UMa-type dwarf novae mainly observed during the 2013-2014 season and characterized these objects. We detected negative superhumps in VW Hyi and indicated that the low number of normal outbursts in some supercycle can be interpreted as a result of the disk tilt. This finding, combined with the Kepler observation of V1504 Cyg and V344 Lyr, suggests that the disk tilt is responsible for modulating the outburst pattern in SU UMa-type dwarf novae. We also studied the deeply eclipsing WZ Sge-type dwarf nova MASTER OT J005740.99+443101.5 and found evidence of a sharp eclipse during the phase of early superhumps. The profile can be reproduced by a combination of the eclipse of the axisymmetric disk and the uneclipsed light source of early superhumps. This finding confirms the lack of evince of a greatly enhanced hot spot during the early stage of WZ Sge-type outburst. We detected g...

Kato, Taichi; Kudzej, Igor; Hambsch, Franz-Josef; Miller, Ian; Ohshima, Tomohito; Nakata, Chikako; Kawabata, Miho; Nishino, Hirochika; Masumoto, Kazunari; Mizoguchi, Sahori; Yamanaka, Masayuki; Matsumoto, Katsura; Sakai, Daisuke; Fukushima, Daiki; Matsuura, Minami; Bouno, Genki; Takenaka, Megumi; Nakagawa, Shinichi; Noguchi, Ryo; Iino, Eriko; Pickard, Roger D; Maeda, Yutaka; Henden, Arne; Kasai, Kiyoshi; Kiyota, Seiichiro; Akazawa, Hidehiko; Imamura, Kazuyoshi; de Miguel, Enrique; Maehara, Hiroyuki; Monard, Berto; Pavlenko, Elena P; Antonyuk, Kirill; Pit, Nikolaj; Antonyuk, Oksana I; Baklanov, Aleksei V; Ruiz, Javier; Richmond, Michael; Oksanen, Arto; Harlingten, Caisey; Shugarov, Sergey Yu; Chochol, Drahomir; Masi, Gianluca; Nocentini, Francesca; Schmeer, Patrick; Bolt, Greg; Nelson, Peter; Ulowetz, Joseph; Sabo, Richard; Goff, William N; Stein, William; Michel, Raul; Dvorak, Shawn; Voloshina, Irina B; Metlov, Vladimir; Katysheva, Natalia; Neustroev, Vitaly V; Sjoberg, George; Littlefield, Colin; Debski, Bartlomiej; Sowicka, Paulina; Klimaszewski, Marcin; Curylo, Malgorzata; Morelle, Etienne; Curtis, Ivan A; Iwamatsu, Hidetoshi; Butterworth, Neil D; Andreev, Maksim V; Parakhin, Nikolai; Sklyanov, Aleksandr; Shiokawa, Kazuhiko; Novak, Rudolf; Irsmambetova, Tat'yana R; Itoh, Hiroshi; Ito, Yoshiharu; Hirosawa, Kenji; Denisenko, Denis; Kochanek, Christopher S; Shappee, Benjamin; Stanek, Krzysztof Z; Prieto, Jose L; Itagaki, Koh-ichi; Stubbings, Rod; Ripero, Jose; Muyllaert, Eddy; Poyner, Gary

2014-01-01

401

Comparing the Precision 2009 and 2012 Light Curves of the Precontact W Uma Binary V1001 Cassiopeia  

NASA Astrophysics Data System (ADS)

A 2012 follow up to the analysis of 2009 observations is presented for the very short period (?0.43 days) precontact W UMa binary (PCWB) V1001 Cassiopeia. Its short period, similar to the majority of W UMa binaries, and its distinct EA light curve make it a very rare and interesting system for continuing photometric investigation. Previous photometric VRI standard magnitudes give a K4 spectral type. Our solutions of light curves separated by some three years give approximately the same physical parameters. However, the spots have radically changed in temperature, area, and position. While only one dark spot was used to model the first curves, two hot spots are now needed. This affects the overall shape of the light curve, especially in the secondary eclipses in B and V. Additional eclipse timings now show that the orbital period is changing. We conclude that spots are very active on this solar-type dwarf system and that it may mimic its larger cousins, the RS CVn binaries. The conclusion is that analysis now needs to be directed at the continuous time evolution of PCWBs.

Samec, R. G.; Koenke, S. S.; Faulkner, D. R.

2015-01-01

402

Photometric Analyses and Spectral Identification of the Early-Spectral Type W UMa Contact Binary V444 Andromedae  

NASA Astrophysics Data System (ADS)

Presented here are the first precision UBVRcIc light curves, synthetic light curve solutions, a period study, and spectrum for V444 Andromedae, an F0V contact W UMa binary. Observations were taken with the Lowell Observatory 0.81-m reflector during 28 through 30 September 2012. From our period study we determined a linear ephemeris showing that the period has been stable over the past 9.6 years (~7,500 orbits). The period during this interval is 0.46877942 d. After a q-search, the lowest residual mass ratio was found to be 0.48 with a Roche-lobe fill-out of nearly 51%. Despite its rather high temperature, 7,300 K, two magnetic spots were modeled on the primary component, a 10° radius equatorial dark spot with a T-factor of 0.88 and a 23° radius near-polar hot spot of T-factor 1.10. The component temperature difference was only ~80 K. These parameters point to a mature, early type, W UMa binary.

Samec, R. G.; Robb, R.; Faulkner, D. R.; Van Hamme, W.

2015-02-01

403

You did what? Clinical errors in EMS.  

PubMed

It was late and you were exhausted. You ran a call that didn't go the way you would have liked. Errors occurred. What actions do you take when your partner is making mistakes? When do you step in? Do you step in? What if there's more to the errors than you realize? This article provides guidelines for EMS personnel to consider when dealing with a scenario that contains clinical errors. Although not an all-inclusive list, the examples and solutions may be beneficial to providers, including rookies and veterans. PMID:11501273

Linder, G; Murphy, P; Streger, M R

2001-08-01

404

EM threat analysis for wireless systems.  

SciTech Connect

Modern digital radio systems are complex and must be carefully designed, especially when expected to operate in harsh propagation environments. The ability to accurately predict the effects of propagation on wireless radio performance could lead to more efficient radio designs as well as the ability to perform vulnerability analyses before and after system deployment. In this report, the authors--experts in electromagnetic (EM) modeling and wireless communication theory--describe the construction of a simulation environment that is capable of quantifying the effects of wireless propagation on the performance of digital communication.

Burkholder, R. J. (Ohio State University Electroscience Laboratory); Mariano, Robert J.; Schniter, P. (Ohio State University Electroscience Laboratory); Gupta, I. J. (Ohio State University Electroscience Laboratory)

2006-06-01

405

Aquisição de Estreptococos Mutans e Desenvolvimento de Cárie Dental em Primogênitos  

PubMed Central

Objetivo Avaliar o momento de aquisição de estreptococos mutans (EM), desenvolvimento de cárie dental e as variáveis a eles associadas no decorrer de 23 meses, em primogênitos de famílias de baixo nível socioeconômico, desde os sete meses de idade. Método A amostra foi selecionada com base em mães densamente colonizadas por EM, incluindo todos os membros de 14 famílias que conviviam na mesma casa. Foram envolvidos no estudo 14 mães, pais e primogênitos e 8 parentes, na maioria avós. Exames clínicos e radiográficos iniciais determinaram os índices de cárie e condição periodontal dos adultos. Contagens de EM foram feitas em todos os adultos nas duas primeiras visitas. Nas crianças foram avaliados os níveis de EM, o número de dentes e de cáries, em quatro visitas. Resultados A prevalência de EM nos adultos foi alta, estando ausente em apenas um dos pais. EM foram detectados em 1, 2, 3 e 10 crianças, respectivamente nas visitas #1, 2, 3 e 4. A cárie dental foi detectada em apenas três crianças na última visita (aos 30 meses de idade), as quais apresentaram escores de EM significantemente maiores que as crianças sem cárie, na mesma visita. Conclusão Exclusivamente a condição social de baixa renda e mães densamente colonizadas por EM não são sinônimo de colonização precoce e alta atividade de cárie em crianças cuidadas em casa. O desenvolvimento de cárie está significantemente associado a escores elevados de EM nas crianças. PMID:22022218

NOCE, Erica; RUBIRA, Cassia Maria Fischer; da Silva ROSA, Odila Pereira; da SILVA, Salete Moura Bonifácio; BRETZ, Walter Antonio

2011-01-01

406

Rito Funerário entre os Florianopolitanos: corpos em diálogo  

Microsoft Academic Search

Abertura Quando os espanhóis encontraram-se com os ameríndios, o que os livros de história teimam em chamar de descobrimento, cosmologias diferentes foram postas em contato, num processo vigoroso de estranhamento do outro. Cada qual a sua maneira tratou de descobrir quem era este \\

Fernando Gonçalves Bitencourt

407

Nonlinear Cyclotron-Resonance Accelerations by a Generalized EM Wave  

E-print Network

). Unlike the usual transit-time accelerations e 00 v 1 this acceleration mechanism is independentNonlinear Cyclotron-Resonance Accelerations by a Generalized EM Wave AKIMOTO, Kazuhiro and HOJO accelerations by a 1D, EM, dispersive pulse in an external magnetic field are investigated. It is found

Boyer, Edmond

408

CURSO DE PS-GRADUAO EM COMPUTAO APLICADA  

E-print Network

Sistemas Complexos Física Matemática Fundamentos da Teoria de Conjuntos Nebulosos e da Teoria de Possibilidades Inteligência Artificial Inteligência Computacional e Aplicações Introdução à Teoria de Sistemas Teoria do Controle Inteligente Testes de Software Baseado em Modelo Tópicos Especiais em Computação

409

Dirio Econmico -Universidades Como ser investigador em Portugal  

E-print Network

Diário Económico - Universidades Como é ser investigador em Portugal Autor: N.D. Editora: ST e SF - Universidades Como é ser investigador em Portugal Autor: N.D. Editora: ST e SF Id: 1646658 Data Publicação: 19

Instituto de Sistemas e Robotica

410

Stochastic EM-based TFBS motif discovery with MITSU  

PubMed Central

Motivation: The Expectation–Maximization (EM) algorithm has been successfully applied to the problem of transcription factor binding site (TFBS) motif discovery and underlies the most widely used motif discovery algorithms. In the wider field of probabilistic modelling, the stochastic EM (sEM) algorithm has been used to overcome some of the limitations of the EM algorithm; however, the application of sEM to motif discovery has not been fully explored. Results: We present MITSU (Motif discovery by ITerative Sampling and Updating), a novel algorithm for motif discovery, which combines sEM with an improved approximation to the likelihood function, which is unconstrained with regard to the distribution of motif occurrences within the input dataset. The algorithm is evaluated quantitatively on realistic synthetic data and several collections of characterized prokaryotic TFBS motifs and shown to outperform EM and an alternative sEM-based algorithm, particularly in terms of site-level positive predictive value. Availability and implementation: Java executable available for download at http://www.sourceforge.net/p/mitsu-motif/, supported on Linux/OS X. Contact: a.m.kilpatrick@sms.ed.ac.uk PMID:24931999

Kilpatrick, Alastair M.; Ward, Bruce; Aitken, Stuart

2014-01-01

411

10 CFR Appendixes E-M to Part 52 - [Reserved  

Code of Federal Regulations, 2010 CFR

10 Energy 2 2010-01-01 2010-01-01 false [Reserved] E Appendixes E-M to Part 52 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS Appendixes E-M to Part 52...

2010-01-01

412

Tuning of EM performance for streamlined aircraft radomes  

Microsoft Academic Search

Aircraft radomes are often streamlined and highly prone to EM performance degradation due to fabrication uncertainties and the non-uniformity of the constituent radome materials. A novel patching scheme is employed for the enhancement of the EM performance. Besides tuning the performance, this patching scheme can also be employed to determine the potential of the radome for any further improvements.

R. U. Nair; R. M. Jha

2004-01-01

413

Esparsidade, Estrutura, Escalamento e Estabilidade em Algebra Linear Computacional  

E-print Network

Sparsity, Structure, Scaling and Stability in Computational Linear Algebra - Textbook from the IX School of Computer Science, held on July 24-31 of 1994 at Recife, Brazil. Esparsidade, Estrutura, Escalamento e Estabilidade em Algebra Linear Computacional - Livro texto da IX Escola de Computacao, realizada nos dias 24 a 31 de Julho de 1994 em Recife, Brasil. This textbook is written in Portuguese Language.

Stern, Julio M

2011-01-01

414

Accuracy of EMS Trauma Transport Destination Plans in North Carolina.  

PubMed

Abstract Objective. Planning for time-sensitive injury may allow emergency medical services (EMS) systems to more accurately triage patients meeting accepted criteria to facilities most capable of providing life-saving treatment. In 2010, North Carolina (NC) implemented statewide Trauma Triage and Destination Plans (TTDPs) in all 100 of North Carolina's county-defined EMS systems. Each system was responsible for identifying the specific destination hospitals with appropriate resources to treat trauma patients. We sought to characterize the accuracy of their hospital designations. Methods. In this cross-sectional study, we collected TTDPs for each county-defined EMS system, including their assigned hospital capabilities (i.e., trauma center or community hospital). We conducted a survey with each EMS system to determine how their TTDP was constructed and maintained, as well as with each TTDP-designated hospital to verify their capabilities. We determined the accuracy of the EMS assigned hospital designations by comparing them to the hospital's reported capabilities. Results. The 100 NC EMS systems provided 380 designations for 112 hospitals. TTDPs were created by EMS administrators and medical directors, with only 55% of EMS systems engaging a hospital representative in the plan creation. Compared to the actual hospital capabilities, 97% of the EMS TTDP designations were correct. Twelve hospital designations were incorrect and the majority (10) overestimated hospital capabilities. Of the 100 EMS systems, 7 misclassified hospitals in their TTDP. EMS systems that did not verify their local hospitals' capabilities during TTDP development were more likely to incorrectly categorize a hospital's capabilities (p = 0.001). Conclusions. A small number of EMS systems misclassified hospitals in their TTDP, but most plans accurately reflected hospital capabilities. Misclassification occurred more often in systems that did not consult local hospitals prior to developing their TTDP. The potential of the TTDP to improve communication between EMS agencies and the facilities with which they work has not been fully realized. EMS agencies or systems should verify local hospital capabilities when engaging in destination planning efforts. PMID:24878396

Moss, Chailee; Cowden, Christopher S; Atterton, Laurie Meyer; Arasaratnam, Meredith H; Fernandez, Antonio R; Evarts, Jeff S; Barrier, Brian; Lerner, E Brooke; Mann, N Clay; Lohmeier, Chad; Shofer, Frances S; Brice, Jane H

2015-01-01

415

Acceleration of MAP-EM algorithm via over-relaxation.  

PubMed

To improve the convergence rate of the effective maximum a posteriori expectation-maximization (MAP-EM) algorithm in tomographic reconstructions, this study proposes a modified MAP-EM which uses an over-relaxation factor to accelerate image reconstruction. The proposed method, called MAP-AEM, is evaluated and compared with the results for MAP-EM and for an ordered-subset algorithm, in terms of the convergence rate and noise properties. The results show that the proposed method converges numerically much faster than MAP-EM and with a speed that is comparable to that for an ordered-subset type method. The proposed method is effective in accelerating MAP-EM tomographic reconstruction. PMID:25465068

Tsai, Yu-Jung; Huang, Hsuan-Ming; Fang, Yu-Hua Dean; Chang, Shi-Ing; Hsiao, Ing-Tsung

2014-11-15

416

Dor em membros em um serviço de reumatologia pediátrica Limb pain in a pediatric rheumatology outpatient clinic  

Microsoft Academic Search

Objetivo: Avaliar clínica e laboratorialmente crianças e adolescentes com dor em membros e sua possível associação com fibromialgia e hipermobilidade articular. Método: Estudo transversal realizado no período de janeiro de 2001 a dezembro de 2002, que incluiu 103 crianças e ado- lescentes atendidos no Ambulatório de Reumatologia Pediá- trica, com queixa de dor em membros. Além do exame físico geral,

Cássia Maria; P. L. Barbosa; Luciana Hangai; Maria Teresa Terreri; Cláudio Arnaldo Len; Maria Odete; E. Hilário

417

Simultaneous Exosat and VLA observations of the W UMa binaries, VW Cep and XY Leo - A flare on VW Cep  

NASA Technical Reports Server (NTRS)

Two UMa-type contact binaries, XY Leo and VW Cep, have been observed simultaneously with Exosat, the VLA, and, in the case of XY Leo, optically. The temporal coverage of each star was sufficient to monitor them throughout two orbital revolutions (P about 0.25 days), however, no orbital modulation of either the X-ray or 6-cm data was seen for either star. A large flare from VW Cep was detected, the first such simultaneous flare ever seen on a star other than the sun. Its behavior before, during, and after the flare is remarkably similar to that found in solar flares. For both stars, it is demonstrated that the 6-cm emission cannot be the result of bremsstrahlung radiation of the X-ray emitting plasma.

Vilhu, Osmi; Caillault, Jean-Pierre; Neff, James; Heise, John

1988-01-01

418

Absolute parameters and physical nature of two W-UMa type binaries: V1123 Tau and V1128 Tau  

NASA Astrophysics Data System (ADS)

We present high-precision, multi-band CCD photometry of two less-studied close binaries V1123 Tau and V1128 Tau. Complete covered light curves and a number of new times of light minima of the two eclipsing systems were obtained, based on which, revised orbital elements and new ephemerides were given. By adopting the Wilson-Devinney method, the light curves were analyzed. The photometric solutions confirm the W UMa-type nature of the binary systems. With the less-massive secondary slightly cooler than the primary, V1123 Tau could be classified as an A-type contact system. While V1128 Tau is typically considered a W-type W UMa star, the surface temperature of its secondary component is determined to be absolutely higher than the primary by about 270 K. Combining with the results of radial-velocity solutions, we determined absolute parameters of the two systems. The mass, radius and luminosity for each component of V1123 Tau were derived as: 1.36 ± 0.05M?, 1.37 ± 0.02R?, and 2.01 ± 0.07L? and 0.40 ± 0.02M?, 0.80 ± 0.01R?, and 0.67 ± 0.04L?, respectively. For V1128 Tau, the absolute parameters were computed to be 1.09 ± 0.03M?, 1.01 ± 0.01R?, and 1.34 ± 0.06L? and 0.58 ± 0.01M?, 0.76 ± 0.01R?, and 0.91 ± 0.05L?, respectively. Based on these results, the evolutionary status and the physical nature of the two binary systems are discussed, while also connecting with the theoretical models.

Zhang, Xiao-Bin; Ren, An-Bin; Luo, Chang-Qing; Luo, Yang-Ping

2011-05-01

419

Phase-resolved HST/STIS spectroscopy of the exposed white dwarf in the high-field polar AR UMa  

E-print Network

Phase-resolved HST/STIS ultraviolet spectroscopy of the high-field polar AR UMa confirms that the WD photospheric Ly alpha Zeeman features are formed in a magnetic field of ~200 MG. In addition to the Ly alpha pi and sigma+ components, we detect the forbidden hydrogen 1s0->2s0 transition, which becomes ``enabled'' in the presence of both strong magnetic and electric fields. Our attempt in fitting the overall optical+UV low state spectrum with single temperature magnetic WD models remains rather unsatisfactory, indicating either a shortcoming in the present models or a new physical process acting in AR UMa. As a result, our estimate of the WD temperature remains somewhat uncertain, Twd=20000+-5000K. We detect a broad emission bump centered at ~1445A and present throughout the entire binary orbit, and a second bump near ~1650A, which appears only near the inferior conjunction of the secondary star. These are suggestive of low harmonic cyclotron emission produced by low-level (M-dot~1e-13 Msun/yr) accretion onto both magnetic poles. However, there is no evidence in the power spectrum of light variations for accretion in gas blobs. The observed Ly alpha emission line shows a strong phase dependence with maximum flux and redshift near orbital phase phi~0.3, strongly indicating an origin on the trailing hemisphere of the secondary star. An additional Ly alpha absorption feature with similar phasing as the Ly alpha emission, but a \\~700km/s blueshift could tentatively be ascribed to absorption of WD emission in a moderately fast wind. We derive a column density of neutral hydrogen of NH=(1.1+-1.0)1e18 cm**-2, the lowest of any known polar.

B. T. Gaensicke; G. D. Schmidt; S. Jordan; P. Szkody

2001-03-08

420

Detection of the white dwarf and the secondary star in the new SU UMa dwarf nova HS 2219+1824  

NASA Astrophysics Data System (ADS)

We report the discovery of a new, non-eclipsing SU UMa-type dwarf nova, HS 2219+1824. Photometry obtained in quiescence (V?17.5) reveals a double-humped light curve from which we derive an orbital period of ?86.2 min. Additional photometry obtained during a superoutburst reaching V?12.0 clearly shows superhumps with a period of ?89.05 min. The optical spectrum contains double-peaked Balmer and He I emission lines from the accretion disc as well as broad absorption troughs of H?, H?, and H? from the white dwarf primary star. Modelling of the optical spectrum implies a white dwarf temperature of 13 000 K?Teff?17 000 K, a distance of 180 pc? d?230 pc, and suggests that the spectral type of the donor star is later than M 5. Phase-resolved spectroscopy obtained during quiescence reveals a narrow H? emission line component which has a radial velocity amplitude and phase consistent with an origin on the secondary star, possibly on the irradiated hemisphere facing the white dwarf. This constitutes the first detection of line emission from the secondary star in a quiescent SU UMa star. Based in part on observations obtained at the German-Spanish Astronomical Center, Calar Alto, operated by the Max-Planck-Institut für Astronomie, Heidelberg, jointly with the Spanish National Commission for Astronomy; on observations made with the IAC80 and OGS telescopes, operated on the island of Tenerife by the Instituto de Astrofísica de Canarias (IAC) and the European Space Agency (ESA), respectively, in the Spanish Observatorio del Teide of the IAC; on observations made at the 1.2 m telescope, located at Kryoneri Korinthias, and owned by the National Observatory of Athens, Greece; and on observations made with the William Herschel Telescope, which is operated on the island of La Palma by the Isaac Newton Group in the Spanish Observatorio del Roque de los Muchachos of the IAC.

Rodríguez-Gil, P.; Gänsicke, B. T.; Hagen, H.-J.; Marsh, T. R.; Harlaftis, E. T.; Kitsionas, S.; Engels, D.

2005-02-01

421

On the origin of W UMa type contact binaries - a new method for computation of initial masses  

NASA Astrophysics Data System (ADS)

W UMa type binaries have two defining characteristics. These are (i) the effective temperatures of both components are very similar, and (ii) the secondary (currently less massive) component is overluminous for its current mass. We consider the latter to be an indication of its mass before the mass transfer event. For these stars, we define a mass difference (?M) between the mass determined from its luminosity and the present mass determined from fitting the binary orbit. We compare the observed values of the mass difference to stellar models with mass-loss. The range of initial secondary masses that we find for observed W UMa type binaries is 1.3-2.6 M?. We discover that the A- and the W-subtype contact binaries have different ranges of initial secondary masses. Binary systems with an initial mass higher than 1.8 ± 0.1 M? become A-subtype while systems with initial masses lower than this become W-subtype. Only 6 per cent of systems violate this behaviour. We also obtain the initial masses of the primaries using the following constraint for the reciprocal of the initial mass ratio: 0 < 1/qi < 1. The range of initial masses we find for the primaries is 0.2-1.5 M?, except for two systems. Finally in comparing our models to observed systems, we find evidence that the mass transfer process is not conservative. We find that only 34 per cent of the mass from the secondary is transferred to the primary. The remainder is lost from the system.

Yildiz, M.; Do?an, T.

2013-04-01

422

BVRcIc Light Curve Analysis of the Shallow Contact Extreme Mass Ratio W UMa Binary, HR Boo  

NASA Astrophysics Data System (ADS)

HR Boo [? (2000) = 14h 48m 33.015s, ? (2000) = +21° 44 ?01.09"] is an NSVS variable first observed in 1999 and listed in the 79th name list (Kazarovets, 2008). It was identified as a W UMa variable and first characterized by the period 0.27289 d. This was later corrected to 0.31587 d. Various observers have reported ~20 timings of minimum light over the past ~4000 orbital epochs. Our 2012 curve is of high precision, with probable errors averaging 5 mmag. The curves have shallow amplitudes, averaging 0.4 magnitudes, yet apparently exhibit total eclipses. J-K observations yield a G6V type for the system. A linear period determination of 0.31596785(7) d was computed with the available timings of minimum light. When the NSVS light curve is considered in the period study, it indicates that the period has been clearly decreasing over the past 15,000 orbits. The quadratic term from this period study is statistically significant at 5 ?. This indicates that the binary is evidently undergoing magnetic breaking due to enhanced magnetic solar activity.The light curve solution reveals that HR Boo is a shallow contact system with a Roche-lobe fill-out of ~4% and a mass ratio of q= 0.25. This is exceedingly rare, since extreme mass ratio binaries usually have high fill-outs. In addition, an unusually dark 13 degree radius cool spot with a T-factor of ~50% was computed near the L1 Point of the primary component. A 32 minute duration of constant light is seen in the secondary eclipse indicating the occurrence of a total eclipse. This was confirmed in the light curve solution. Although the secondary component has a slightly higher temperature than the primary component, some 30 K, the light curves have the appearance of an A-type W UMa system. The system may have come into contact recently.

Faulkner, Danny R.; Samec, Ronald G.; Shebs, Travis; Benkendorf, Barry

2014-06-01

423

The Post-LBV Supernova 2001em  

NASA Astrophysics Data System (ADS)

The supernova (SN) 2001em in UGC 11794 was classified early as Type Ib/c, i.e., as one arising from a hydrogen-stripped star. As part of a radio survey with the Very Large Array of SNe Ib/c at late times (Stockdale et al. 2003, BAAS, 35, 1346), SN 2001em was detected as a highly luminous radio source ˜2 years after explosion. The SN was also subsequently discovered with Chandra to be a very luminous X-ray source. The properties of both the radio and X-ray emission are more characteristic of the Type II-narrow (IIn) SNe, where the SN shock is interacting with dense, massive circumstellar matter, resulting in bright radio synchrotron emission and thermal bremsstrahlung from the interaction region. In fact, SN 2001em has shown to have spectroscopically transformed to a SN IIn. The premise that this might indicate an off-axis gamma-ray burst has been presented (Granot & Ramirez-Ruiz 2004, ApJ, 609, L9) and later, rather convincingly, refuted (e.g., Schinzel et al. 2009, ApJ, 691, 1380). Chugai & Chevalier (2006, ApJ, 641, 1051) have interpreted the spectral transformation and radio/X-ray emission as the SN shock overtaking the detached hydrogen envelope of the progenitor star, which was shed in a superwind episode many years prior to explosion. Chevalier (2007, RMxAC, 30, 41) has further pointed to the required mass-loss rate in the event being equivalent to what would occur in the eruption of a luminous blue variable (LBV). The optical (ground-based and HST) and radio/X-ray data, together with mid-infrared Spitzer observations, tend to support this scenario of a very massive star that experienced a powerful LBV outburst prior to explosion. Such an event may not be unique, with possible parallels in the cases of SNe 2005bf and 2006jc, and may provide valuable new information about massive stellar evolution.

Van Dyk, Schuyler D.; Chornock, R.; Filippenko, A. V.; Foley, R. J.; Lewin, W. H. G.; Li, W.; Panagia, N.; Pooley, D.; Stockdale, C. J.; Weiler, K. W.

2009-12-01

424

Electromagnetic optimization of EMS-MAGLEV systems  

SciTech Connect

In EMS-MAGLEV high-speed transport systems, devices for propulsion, levitation and contactless on-board electric power transfer are combined in a single electromagnetic structure. The strong coupling among the windings affects the performance of each device and requires the utilization of numerical codes. The paper describes an overall optimization procedure, based on a suitable mathematical model of the system, which takes into account several items of the system performance. The parameters of the model are calculated by an automated sequence of FEM analyses of the configuration. Both the linear generator output characteristics and the propulsion force ripple are improved applying the procedure to a reference configuration. The results are compared with the results obtained by a sequence of partial optimizations operating separately on two different subsets of the geometric parameters.

Andriollo, M.; Martinelli, G.; Morini, A.; Tortella, A. [Univ. of Padova (Italy). Dept. of Electrical Engineering] [Univ. of Padova (Italy). Dept. of Electrical Engineering

1998-07-01

425

DOE EM industry programs robotics development  

SciTech Connect

The Office of Science and Technology (OST) manages an aggressive program for RD&D, as well as testing and evaluation for the U.S. Department of Energy`s (DOE) Environmental Management (EM) organization. The goal is to develop new and improved environmental restoration and waste management technologies to clean up the inventory of the DOE weapons complex faster, safer, and cheaper than is possible with currently available technologies. OST has organized technology management activities along focus teams for each major problem area. There are currently five focus areas: decontamination and decommissioning, tanks, subsurface contaminants, mixed waste, and plutonium. In addition, OST is pursuing research and development (R&D) that cuts across these focus areas by having applications in two or more focus areas. Currently, there are three cross-cutting programs: the robotics technology development; characterization, monitoring, and sensor technologies; and efficient separations and processing.

Staubly, R.; Kothari, V. [Dept. of Energy, Morgantown, WV (United States)

1997-12-01

426

Elevated ethyl methanesulfonate (EMS) in nelfinavir mesylate (Viracept, Roche): overview.  

PubMed

Roche's protease inhibitor nelfinavir mesylate (Viracept) produced between March 2007-June 2007 was found to contain elevated levels of ethyl methanesulfonate (EMS), a known mutagen (alkylator) - leading to a global recall of the drug. EMS levels in a daily dose (2,500 mg Viracept/day) were predicted not to exceed a dose of approximately 2.75 mg/day (approximately 0.055 mg/kg/day based on 50 kg patient). As existing toxicology data on EMS did not permit an adequate patient risk assessment, a comprehensive animal toxicology evaluation of EMS was conducted. General toxicity of EMS was investigated in rats over 28 days. Two studies for DNA damage were performed in mice; chromosomal damage was assessed using a micronucleus assay and gene mutations were detected using the MutaMouse transgenic model. In addition, experiments designed to extrapolate animal exposure to humans were undertaken. A general toxicity study showed that the toxicity of EMS occurred only at doses >or= 60 mg/kg/day, which is far above that received by patients. Studies for chromosomal damage and mutations in mice demonstrated a clear threshold effect with EMS at 25 mg/kg/day, under chronic dosing conditions. Exposure analysis (Cmax) demonstrated that approximately 370-fold higher levels of EMS than that ingested by patients, are needed to saturate known, highly conserved, error-free, mammalian DNA repair mechanisms for alkylation. In summary, animal studies suggested that patients who took nelfinavir mesylate with elevated levels of EMS are at no increased risk for carcinogenicity or teratogenicity over their background risk, since mutations are prerequisites for such downstream events. These findings are potentially relevant to >40 marketed drugs that are mesylate salts. PMID:19660105

Pozniak, Anton; Müller, Lutz; Salgo, Miklos; Jones, Judith K; Larson, Peter; Tweats, David

2009-01-01

427

Evaluation of Fracture Azimuth by EM Wave and Elastic Wave  

NASA Astrophysics Data System (ADS)

Fracture system plays an important role in the development of underground energy, for example enhanced geothermal system (EGS), oil shale and shale gas, etc. Therefore, it becomes more and more important to detect and evaluate the fracture system. Geophysical prospecting is an useful method to evaluate the characteristics of the subsurface fractures. Currently, micro-seismology, multi-wave seismic exploration, and electromagnetic (EM) survey are reported to be used for the purpose. We are studying a method using both elastic wave and EM wave to detect and evaluate the fracture azimuth in laboratory. First, we build a 3D horizontal transverse isotropy (HTI) model, shown in the figure 1, by dry parallel fractures system, which was constructed by plexiglass plates and papers. Then, we used the ultrasonic system to obtain reflected S-wave data. Depending on the shear wave splitting, we evaluated the fracture azimuth by the algorithm of Pearson correlation coefficient. In addition, we used the full Polarimetric ultra wide band electromagnetic (FP-UWB-EM) wave System, shown in the figure 2, to obtain full polarimetric reflected EM-wave data. Depending on the rotation of the EM wave polarimetry, we evaluated the fracture azimuth by the the ration between maximum amplitude of co-polarimetric EM wave and maximum amplitude of cross-polarimetric EM wave. Finally, we used both EM-wave data and S-wave data to evaluate the fracture azimuth by the method of cross plot and statistical mathematics. To sum up, we found that FP-UWB-EM wave can be used to evaluated the fracture azimuth and is more accurate than ultrasound wave. Also joint evaluation using both data could improve the precision.

Feng, X.; Wang, Q.; Liu, C.; Lu, Q.; Zeng, Z.; Liang, W.; Yu, Y.; Ren, Q.

2013-12-01

428

Theory of EM monitoring of sea bottom geothermal areas  

NASA Astrophysics Data System (ADS)

Monitoring of geophysical conditions of marine sedimentary basins is necessary for predicting seismic events and for adaptation of geothermal technologies for seismically active (as a rule) sea bottom geothermal areas. These conditions are characterized by seismo-hydro-electromagnetic (EM) geophysical field interaction in the presence of gravity. Based on the main physical principles, geophysical and petrophysical data, we formulate a mathematical model of seismo-hydro-EM interaction in a basin of a marginal sea and calculate the transformation of a seismic excitation in the upper mantle under the central part of the sea of Japan into the low-frequency (0.1 to 10 Hz) EM signals at the top of the sea bottom sedimentary layer, at the sea surface and in the atmosphere up to the lower boundary of the ionosphere. Physics of the EM generation and propagation process is shown including: generation of EM waves in the upper mantle layer M by a seismic wave from under M, spatial modulation of diffusive EM waves by a seismic wave, stopping of the EM wave arrived (before the seismic P wave) from the upper mantle at the top of the sediments because of the high electric conductivity of seawater (3.5 S/m), immediate penetration of the EM wave through the seawater thickness after the delayed seismic P wave shock into the sea bottom, and EM emission from the sea surface into the atmosphere. Let us note that the EM signal in the sea bottom sediments is the first measurable signal of a seismic activation of geological structures beneath the seafloor and this signal is protected by seawater from the influence ionosphere disturbances. Amplitude of the computed magnetic signals (300, 200, 50, and 30 pT at the ocean-atmosphere interface and at the height of 10, 30 and 50 km, respectively), their predominant frequency (0.25 Hz), the delay of the seismic P wave in regard to the magnetic signal for the receivers at the shore (20 s), the amplitude of temperature disturbances in sediments (up to 0.02 K), the parameters of the long (150 km) tsunami wave of a small (up to 20 cm) amplitude far from the shore and other values that characterize the seismo-hydro-EM process are of the orders observed. Recommendations for the EM monitoring of dynamic processes beneath seafloor geothermal areas are given.

Ershov, Sergey; Mikhaylovskaya, Irina; Novik, Oleg

2006-04-01

429

UNIVERSIDADE DE BRASLIA PROGRAMA DE PS-GRADUAO EM COMUNICAO  

E-print Network

Experiência profissional em comunicação 5 Produção científica na área de comunicação (artigos, livros e capítulos) 10 Produção científica em outras áreas de conhecimento (artigos, livros e capítulos) 5 (artigos, livros e 10 #12;3 capítulos) Produção científica em outras áreas de conhecimento (artigos, livros

Maier, Rudolf Richard

430

MTODOS DE PROCURA EM LINHA (sem recurso a derivadas)  

E-print Network

o nº de iterações necessárias para atingir uma certa precisão. #12;Método da Golden Section Seja ak ,bk[ ] o intervalo de incerteza na iteração k do método de Golden Section. Pelo teorema T1 o novo

Instituto de Sistemas e Robotica

431

Um SGBD com Armazenamento Distribuido de Dados Baseado em DHT  

E-print Network

, Ana Paula Dias1 , Arion de Campos Jr.1,2 , Davi Arnaut1 , Carmem Hara1 1 Departamento de Inform´arios. Uma das propri- edades das redes P2P ´e o seu car´ater descentralizado, sem a figura de um respons

Hara, Carmem Satie

432

Uma visao do espaco na mecanica newtoniana e na teoria da relatividade de Einstein (A space view in newtonian mechanics and Einstein's theory of relativity)  

Microsoft Academic Search

Esse trabalho apresenta uma exposicao conceitual, sem qualquer recurso ao formalismo matematico, das ideias de espaco e de tempo, desde a mecanica newtoniana, que se fundamenta no conceito de espaco absoluto, ate as grandes transformacoes introduzidas pela teoria da relatividade de Einstein. Enfatizamos as cr´õticas fi- losoficasan ocao desse espaco absoluto, completamente objetivo e anterior a toda experiencia, bem como

C. M. Porto

433

Environmental Education and Development Division (EM-522). Annual report, Fiscal year 1993  

SciTech Connect

The Environmental Education and Development Division (EM-522) is one of three divisions within the Office of Technology Integration and Environmental Education and Development (EM-52) in Environmental Restoration and Waste Management`s (EM`s) Office of Technology Development (EM-50). The primary design criterion for EM-522 education activities is directly related to meeting EM`s goal of environmental compliance on an accelerated basis and cleanup of the 1989 inventory of inactive sites and facilities by the year 2019. Therefore, EM-522`s efforts are directed specifically toward stimulating knowledge and capabilities to achieve the goals of EM while contributing to DOE`s overall goal of increasing scientific, mathematical, and technical literacy and competency. This report discusses fiscal year 1993 activities.

Not Available

1993-12-31

434

Efficacy of Droncit R Spot-on (praziquantel) 4% w\\/v against immature and mature Echinococcus multilocularis in cats  

Microsoft Academic Search

The causative agent of alveolar hydatidosis in humans, the fox tapeworm Echinococcusmultilocularis, is extending its geographical range in Europe and has been found in domestic cats in some areas. A dermally applied cestocidal treatment for domestic cats has been developed and the efficacy of this treatment is reported. Thirty purpose-bred cats were experimentally infected each with 10?000 protoscoleces of Echinococcusmultilocularis.

David J Jenkins; Thomas Romig

2000-01-01

435

THE CONTROL OF FISH PARASITES AND THE ERADICATION OF ASIAN TAPEWORM INFECTIONS IN GRASS CARP USING PRAZIQUANTEL BATH TREATMENTS  

Technology Transfer Automated Retrieval System (TEKTRAN)

There are few studies on the control of fish parasites and even fewer effective or accepted methods for the direct or indirect control of these parasites. When parasite eradication from fish stocks is the goal, the probability for success is very low. Condition of host, life cycle of parasite, wate...

436

Truncated and constrained helical analogs of antimicrobial esculentin-2EM.  

PubMed

Esculentin-2EM is a 37-residue, cationic, amphipathic, ?-helical antimicrobial peptide isolated from a Korean frog, Glandirama emeljanovi. Many studies revealed that truncation of this peptide results in substantial decreases in its antimicrobial activity. Lee and his colleagues have recently reported that a 23-residue esculentin-2EM analog containing a tryptophanyl substitution at position 16 showed a significant recovery of the antimicrobial activity of the parent peptide. Here we report a new series of 15-residue esculentin-2EM analogs which are constrained into an ?-helical conformation via an oct-4-enyl cross-link. The resulting 'stapled' derivatives displayed remarkable increases not only in antimicrobial activity but also in helical content and protease resistance compared to Lee's original 23-residue esculentin-2EM analog. The preliminary data obtained in this work strongly supports the potential of our strategy for the development of a new class of peptide antibiotics. PMID:24211019

Pham, Thanh Kim; Kim, Do-Hee; Lee, Bong-Jin; Kim, Young-Woo

2013-12-15

437

Genética de populações e relações de parentesco em Ciconiiformes (Aves).  

E-print Network

??Estudos de genética de populações e de parentesco genético foram desenvolvidos em colhereiro (Platalea ajaja), cabeça-seca (Mycteria americana) e garça-branca-grande (Ardea alba egretta), de colônias… (more)

Carolina Isabel Miño

2010-01-01

438

Structure of Matter, Forces, EM Waves, Spectroscopy, Doppler Effect  

NSDL National Science Digital Library

These supplemental class notes cover the basic properties of matter, the nature of forces, the electromagnetic spectrum, and how astronomers exploit the properties of the EM spectrum to deduce the physical nature of distant objects.

O'Connell, Robert

2005-06-28

439

E.M. and Hadronic Shower Simulation with FLUKA  

SciTech Connect

A description of the main features of e.m. and hadronic shower simulation models used in the FLUKA code is summarized and some recent applications are discussed. The general status of the FLUKA project is also reported.

Battistoni, G.; Fasso, A.; Ferrari, A.; Ranft, J.; Rubbia, A.; Sala, P.R.; /INFN, Milan /SLAC /CERN /Siegen U. /Zurich, ETH

2005-10-03

440

NASA EM Followup of LIGO-Virgo Candidate Events  

NASA Technical Reports Server (NTRS)

We present a strategy for a follow-up of LIGO-Virgo candidate events using offline survey data from several NASA high-energy photon instruments aboard RXTE, Swift, and Fermi. Time and sky-location information provided by the GW trigger allows for a targeted search for prompt and afterglow EM signals. In doing so, we expect to be sensitive to signals which are too weak to be publicly reported as astrophysical EM events.

Blackburn, Lindy L.

2011-01-01

441

EM Telemetry Tool for Deep Well Drilling Applications  

SciTech Connect

This final report discusses the successful development and testing of a deep operational electromagnetic (EM) telemetry system, produced under a cooperative agreement with the United States Department of Energy's National Energy Technology Laboratory. This new electromagnetic telemetry system provides a wireless communication link between sensors deployed deep within oil and gas wells and data acquisition equipment located on the earth's surface. EM based wireless telemetry is a highly appropriate technology for oil and gas exploration in that it avoids the need for thousands of feet of wired connections. In order to achieve the project performance objectives, significant improvements over existing EM telemetry systems were made. These improvements included the development of new technologies that have improved the reliability of the communications link while extending operational depth. A key element of the new design is the incorporation of a data-fusion methodology which enhances the communication receiver's ability to extract very weak signals from large amounts of ambient environmental noise. This innovative data-fusion receiver based system adapts advanced technologies, not normally associated with low-frequency communications, and makes them work within the harsh drilling environments associated with the energy exploration market. Every element of a traditional EM telemetry system design, from power efficiency to reliability, has been addressed. The data fusion based EM telemetry system developed during this project is anticipated to provide an EM tool capability that will impact both onshore and offshore oil and gas exploration operations, for conventional and underbalanced drilling applications.

Jeffrey M. Gabelmann

2005-11-15

442

Evaluation of Use of Recombinant Em18 and Affinity-Purified Em18 for Serological Differentiation of Alveolar Echinococcosis from Cystic Echinococcosis and Other Parasitic Infections  

Microsoft Academic Search

To further evaluate recombinant Em18 antigen (rEm18) for immunodiagnosis of human alveolar echino- coccosis, 208 serum samples were examined by enzyme-linked immunosorbent assay (ELISA). To compara- tively assess the results of rEm18-ELISA, ELISA and immunoblot analysis with two affinity-purified native antigens were also performed with 45 selected serum samples. The results indicate that rEm18 is highly useful for serodiagnosis.

Ning Xiao; Wulamu Mamuti; Hiroshi Yamasaki; Yasuhito Sako; Minoru Nakao; Kazuhiro Nakaya; Bruno Gottstein; Peter M. Schantz; Marshall W. Lightowlers; Philip S. Craig; Akira Ito

2003-01-01

443

Isolamento de Salmonella spp. em pombos (Columba livia) no Distrito Federal : aspecto de relevância ao sistema de vigilância em saúde.  

E-print Network

??Dissertação (mestrado)—Universidade de Brasília, Faculdade de Agronomia e Medicina Veterinária, Programa de Pós-Graduação em Saúde Animal, 2014. A domesticação de pombos da espécie Columba livia,… (more)

Santos, Ivanildo de Oliveira Correia

2014-01-01

444

Speciation, population structure, and demographic history of the Mojave Fringe-toed Lizard (Uma scoparia), a species of conservation concern  

PubMed Central

The North American deserts were impacted by both Neogene plate tectonics and Quaternary climatic fluctuations, yet it remains unclear how these events influenced speciation in this region. We tested published hypotheses regarding the timing and mode of speciation, population structure, and demographic history of the Mojave Fringe-toed Lizard (Uma scoparia), a sand dune specialist endemic to the Mojave Desert of California and Arizona. We sampled 109 individual lizards representing 22 insular dune localities, obtained DNA sequences for 14 nuclear loci, and found that U. scoparia has low genetic diversity relative to the U. notata species complex, comparable to that of chimpanzees and southern elephant seals. Analyses of genotypes using Bayesian clustering algorithms did not identify discrete populations within U. scoparia. Using isolation-with-migration (IM) models and a novel coalescent-based hypothesis testing approach, we estimated that U. scoparia diverged from U. notata in the Pleistocene epoch. The likelihood ratio test and the Akaike Information Criterion consistently rejected nested speciation models that included parameters for migration and population growth of U. scoparia. We reject the Neogene vicariance hypothesis for the speciation of U. scoparia and define this species as a single evolutionarily significant unit for conservation purposes. PMID:25360285

Gottscho, Andrew D; Marks, Sharyn B; Jennings, W Bryan

2014-01-01

445

Speciation, population structure, and demographic history of the Mojave Fringe-toed Lizard (Uma scoparia), a species of conservation concern.  

PubMed

The North American deserts were impacted by both Neogene plate tectonics and Quaternary climatic fluctuations, yet it remains unclear how these events influenced speciation in this region. We tested published hypotheses regarding the timing and mode of speciation, population structure, and demographic history of the Mojave Fringe-toed Lizard (Uma scoparia), a sand dune specialist endemic to the Mojave Desert of California and Arizona. We sampled 109 individual lizards representing 22 insular dune localities, obtained DNA sequences for 14 nuclear loci, and found that U. scoparia has low genetic diversity relative to the U. notata species complex, comparable to that of chimpanzees and southern elephant seals. Analyses of genotypes using Bayesian clustering algorithms did not identify discrete populations within U. scoparia. Using isolation-with-migration (IM) models and a novel coalescent-based hypothesis testing approach, we estimated that U. scoparia diverged from U. notata in the Pleistocene epoch. The likelihood ratio test and the Akaike Information Criterion consistently rejected nested speciation models that included parameters for migration and population growth of U. scoparia. We reject the Neogene vicariance hypothesis for the speciation of U. scoparia and define this species as a single evolutionarily significant unit for conservation purposes. PMID:25360285

Gottscho, Andrew D; Marks, Sharyn B; Jennings, W Bryan

2014-06-01

446

The first photometric analysis and period investigation of the W UMa type binary system V1139 Cas  

NASA Astrophysics Data System (ADS)

V1139 Cas, which is a very short period W UMa type binary star, was a neglected object since its discovery. BVRI light curves of this system observed using the 1 m telescope at Weihai Observatory of Shandong University are presented and are analyzed using the Wilson-Devinney code. It is discovered that V1139 Cas is a shallow contact binary system (f=3.6%) with a mass ratio of q=1.583. By using all available times of minimum light, the orbital period variation is studied for the first time. We found that the orbital period has varied by a combination of an downward parabola and a sinusoid. The downward parabola means continuous period decrease at a rate of dP/dt=3.66×10-7 d yr-1 and may be caused by angular momentum loss via stellar wind. The sinusoidal variation with a period of 12.8 yr and a semi-amplitude of 0.0064 days can most likely be interpreted as the light travel time effect due to the existence of an unseen tertiary companion.

Li, K.; Hu, S.-M.; Guo, D.-F.; Jiang, Y.-G.; Gao, D.-Y.; Chen, X.

2015-01-01

447

DOE EM industry programs robotics development  

SciTech Connect

The Office of Science and Technology (OST) manages an aggressive program for RD and D, as well as testing and evaluation for the Department of Energy`s (DOE`s) Environmental Management (EM) organization. The goal is to develop new and improved environmental restoration and waste management technologies to clean up the inventory of the DOE weapons complex faster, safer, and cheaper than is possible with currently available technologies. Robotic systems reduce worker exposure to the absolute minimum, while providing proven, cost-effective, and, for some applications, the only acceptable technique for addressing challenging problems. Development of robotic systems for remote operations occurs in three main categories: tank waste characterization and retrieval; decontamination and dismantlement; and characterization, mapping, and inspection systems. In addition, the Federal Energy Technology Center (FETC) has some other projects which fall under the heading of supporting R and D. The central objective of all FETC robotic projects is to make robotic systems more attractive by reducing costs and health risks associated with the deployment of robotic technologies in the cleanup of the nuclear weapons complex. This will be accomplished through development of robots that are cheaper, faster, safer, and more reliable, as well as more straightforward to modify/adapt and more intuitive to operate with autonomous capabilities and intelligent controls that prevent accidents and optimize task execution.

Staubly, R.; Kothari, V.

1998-12-31

448

Image segmentation by EM-based adaptive pulse coupled neural networks in brain magnetic resonance imaging.  

PubMed

We propose an automatic hybrid image segmentation model that integrates the statistical expectation maximization (EM) model and the spatial pulse coupled neural network (PCNN) for brain magnetic resonance imaging (MRI) segmentation. In addition, an adaptive mechanism is developed to fine tune the PCNN parameters. The EM model serves two functions: evaluation of the PCNN image segmentation and adaptive adjustment of the PCNN parameters for optimal segmentation. To evaluate the performance of the adaptive EM-PCNN, we use it to segment MR brain image into gray matter (GM), white matter (WM) and cerebrospinal fluid (CSF). The performance of the adaptive EM-PCNN is compared with that of the non-adaptive EM-PCNN, EM, and Bias Corrected Fuzzy C-Means (BCFCM) algorithms. The result is four sets of boundaries for the GM and the brain parenchyma (GM+WM), the two regions of most interest in medical research and clinical applications. Each set of boundaries is compared with the golden standard to evaluate the segmentation performance. The adaptive EM-PCNN significantly outperforms the non-adaptive EM-PCNN, EM, and BCFCM algorithms in gray mater segmentation. In brain parenchyma segmentation, the adaptive EM-PCNN significantly outperforms the BCFCM only. However, the adaptive EM-PCNN is better than the non-adaptive EM-PCNN and EM on average. We conclude that of the three approaches, the adaptive EM-PCNN yields the best results for gray matter and brain parenchyma segmentation. PMID:20042313

Fu, J C; Chen, C C; Chai, J W; Wong, S T C; Li, I C

2010-06-01

449

FitEM2EM--tools for low resolution study of macromolecular assembly and dynamics.  

PubMed

Studies of the structure and dynamics of macromolecular assemblies often involve comparison of low resolution models obtained using different techniques such as electron microscopy or atomic force microscopy. We present new computational tools for comparing (matching) and docking of low resolution structures, based on shape complementarity. The matched or docked objects are represented by three dimensional grids where the value of each grid point depends on its position with regard to the interior, surface or exterior of the object. The grids are correlated using fast Fourier transformations producing either matches of related objects or docking models depending on the details of the grid representations. The procedures incorporate thickening and smoothing of the surfaces of the objects which effectively compensates for differences in the resolution of the matched/docked objects, circumventing the need for resolution modification. The presented matching tool FitEM2EMin successfully fitted electron microscopy structures obtained at different resolutions, different conformers of the same structure and partial structures, ranking correct matches at the top in every case. The differences between the grid representations of the matched objects can be used to study conformation differences or to characterize the size and shape of substructures. The presented low-to-low docking tool FitEM2EMout ranked the expected models at the top. PMID:18974836

Frankenstein, Ziv; Sperling, Joseph; Sperling, Ruth; Eisenstein, Miriam

2008-01-01

450

Degradation of Benzodiazepines after 120 Days of EMS Deployment  

PubMed Central

Introduction EMS treatment of status epilepticus improves outcomes, but the benzodiazepine best suited for EMS use is unclear, given potential high environmental temperature exposures. Objective To describe the degradation of diazepam, lorazepam, and midazolam as a function of temperature exposure and time over 120 days of storage on active EMS units. Methods Study boxes containing vials of diazepam, lorazepam, and midazolam were distributed to 4 active EMS units in each of 2 EMS systems in the southwestern United States during May–August 2011. The boxes logged temperature every minute and were stored in EMS units per local agency policy. Two vials of each drug were removed from each box at 30-day intervals and underwent high-performance liquid chromatography to determine drug concentration. Concentration was analyzed as mean (and 95%CI) percent of initial labeled concentration as a function of time and mean kinetic temperature (MKT). Results 192 samples were collected (2 samples of each drug from each of 4 units per city at 4 time-points). After 120 days, the mean relative concentration (95%CI) of diazepam was 97.0% (95.7–98.2%) and of midazolam was 99.0% (97.7–100.2%). Lorazepam experienced modest degradation by 60 days (95.6% [91.6–99.5%]) and substantial degradation at 90 days (90.3% [85.2-95.4%]) and 120 days (86.5% [80.7–92.3%]). Mean MKT was 31.6°C (95%CI 27.1–36.1). Increasing MKT was associated with greater degradation of lorazepam, but not midazolam or diazepam. Conclusions Midazolam and diazepam experienced minimal degradation throughout 120 days of EMS deployment in high-heat environments. Lorazepam experienced significant degradation over 120 days and appeared especially sensitive to higher MKT exposure. PMID:24548058

McMullan, Jason T.; Jones, Elizabeth; Barnhart, Bruce; Denninghoff, Kurt; Spaite, Daniel; Zaleski, Erin; Silbergleit, Robert

2014-01-01

451

Epidemiology of co-sleeping and nighttime waking at 12 months in a birth cohort Epidemiologia do co-leito e do despertar noturno aos 12 meses de idade em uma coorte de nascimentos  

Microsoft Academic Search

Objective: To investigate the prevalence and factors associated with co-sleeping and nighttime waking among the children of the Pelotas 2004 cohort at 12 months of age. Methods: All children born in the city of Pelotas, RS, Brazil during 2004 were enrolled on a longitudinal study. Mothers were interviewed at delivery and once more at 12 months of age to obtain

Iná S. Santos; Denise M. Mota; Alicia Matijasevich

452

O Método Mãe Canguru em hospitais públicos do Estado de São Paulo, Brasil: uma análise do processo de implantação Kangaroo Mother Care in public hospitals in the State of São Paulo, Brazil: an analysis of the implementation process  

Microsoft Academic Search

This study analyzed the implementation of the Kangaroo Mother method in 28 different São Paulo State public hospitals. Teaching hospi- tals, Baby-Friendly Hospitals, hospitals with human milk banks, and those with more than 12 trained health professionals showed higher implementation scores. Because of staff resis- tance to family participation in neonatal care, the Kangaroo Mother method is basically ap- plied

Ana Júlia Colameo; Marina Ferreira Rea

453

PERCEPÇÃO DOS ALUNOS SOBRE A INCORPORAÇÃO DE ELEMENTOS DE FÍSICA MODERNA E CONTEMPORÂNEA EM UMA DISCIPLINA INTRODUTÓRIA DO CURSO DE FÍSICA. ALUMNI'S PERCEPTION ON THE INCLUSION OF CONTEMPORANEOUS AND MODERN PHYSICS ELEMENTS IN A PHYSICS COURSE INTRODUCTORY DISCIPLINE. S  

Microsoft Academic Search

The inclusion of the Modern Physics in both High School and University initial semesters has been thought for a long time. Justifications have been pointed towards incitement and stimulation. However, when we think about education in universities, there is a worry concerning to the future teachers formation. A professor's didactical experience who inserted contemporaneous and modern physics elements in his

Ana A. Diniz; Ruy C. M. C. Ferraz; Alice Helena; C. Pierson

2008-01-01

454

Laparoscopic treatment for incisional lumbar hernia in kidney donor: a new minimally invasive and efficient alternative Tratamento laparoscópico de hérnia lombar incisional em doador renal: uma nova opção minimamente invasiva e eficiente  

Microsoft Academic Search

This report describes and discusses a new therapeutic laparoscopic technique for incisional hernia secondary to lumbotomy in a kidney donor. The transperitoneal laparoscopic approach was used with the patient placed in left lateral decubitus. Three trocars were placed during the surgery: the first, a 10-mm trocar at the level of the umbilical scar; the second, a 5-mm trocar at the

Marcos Tobias-Machado; Freddy de Jesús Rincón; Marco Túlio; Coelho Lasmar; Roberto Vaz Juliano; Eric Roger Wroclawski

455

A teoria, o livro didático e o professor: uma análise da implementação de tarefas orais em LE (The theory, the textbook and the teacher: an analysis of the implementation of oral tasks in foreign language teaching)  

Microsoft Academic Search

3 ABSTRACT: This paper investigates how EFL oral activities are implemented in the classroom and focuses on the relationship between pedagogical theory, the textbook, and the teacher. Data were collected through classroom observation and an interview with the participant teacher. The qualitative analysis of results indicates that speaking is not treated in its own right and is used as a

Raquel Carolina; Souza Ferraz; Mailce Borges MOTA

456

Learning when to Hold'em and When to Fold'em: ERS's Budget Hold'em Game Facilitates the Budget Development Process in Memphis  

ERIC Educational Resources Information Center

If your school district is facing a budget issue, it might surprise you to learn that the solution might very well lie in a game of cards. That certainly was the case earlier this year for the city schools of Memphis, Tennessee. The game is called Budget Hold'em, and it was developed by Education Resource Strategies (ERS) of Watertown,…

Education Resource Strategies, 2010

2010-01-01

457

Livro de actividades em ToonTalk para o pré-escolar  

Microsoft Academic Search

Como orientação para os educadores, foi desenvolvido um conjunto de actividades adequadas a contextos de educação pré-escolar (crianças dos 3 aos 5 anos, na presença de educadores), que se apoiam no videojogo - ou videobrinquedo - ToonTalk. Para permitir uma fácil compreensão e acompanhamento por parte de crianças e educadores, foi então desenvolvida uma forma gráfica de transmitir essas actividades,

Leonel Morgado; Maria Gabriel Bulas Cruz; Ana Teresa Tavares; Christophe Moura

458

UBVRI Photometric Study of the Totally Eclipsing 6500 K Extreme Mass Ratio W UMa Binary, GSC 3208 1986  

NASA Astrophysics Data System (ADS)

We present high precision, UBVRcIc light curves of the suspected eclipsing binary, GSC 3208 1986. The amplitudes of the light curve is very nearly 0.5 mag in all filters. The present curves are immaculate with all spot activity hidden within the low noise of the light curves. The minima are equal to within 0.1 mags. The Wilson Devinney program simultaneous light curve solution shows that this is a totally eclipsing classic A-type, EW binary. GSC 3208 1986 is an extreme mass ratio, 6500 K, W UMa system. The mass ratio is only 0.24, with a component temperature difference of only ~100K. This points to a high degree of thermal and physical contact. Indeed, the Roche lobe fill-out is 39%. The high inclination of 85° results in a long duration secondary total eclipse (an interval of constant light), some 49.5 minutes! The binary is of F6V type, and has no modeled surface discontinuities (no spots were needed in the modeling). The period study of a 13 year time duration indicates that the period is steadily decreasing. This is expected in solar type binaries undergoing magnetic braking. The variable is apparently undergoing solar-type activity with its associated magnetic breaking despite the near absence of spot distortions in the light curves. However, an early curve by Gettel et al. (2006) may give evidence for this. All indications are that this binary is mature and approaching a transitional coalescence into a fast rotating A-type star (Guinan and Bradstreet 1988).

Samec, Ronald G.; Faulkner, Danny R.; Van Hamme, Walter V.; Kring, James

2014-06-01

459

Photometric study and preliminary elements of the low-mass ratio W UMa system ASAS 021209+2708.3  

NASA Astrophysics Data System (ADS)

We present CCD B and V light curves, obtained in the year 2006, and a photometric solution of the low-mass ratio contact binary ASAS 021209+2708.3. With our data we were able to determine six new times of minimum light and refine the orbital period of the system to 0.3181963 days. The light curves are analyzed using the 2003 version of the Wilson-Devinney program and the analysis was performed with and without adding a spot on the surface of one star because the light curves appear to exhibit a typical O'Connell effect, with Maximum I brighter than Maximum II. The results show that ASAS 021209+2708.3 may be classified as an A-subtype W Ursae Majoris system with a small mass ratio q = 0.1889, a large over-contact degree of f = 0.587, a very small difference between the component temperatures of ?T = 53 K and an orbital inclination of i = 81°. It is known that deep (f > 50%), low-mass ratio (q < 0.25) overcontact binary stars are a very important resource for understanding the phenomena of Blue Straggler/FK Com-type stars. The formations of Blue Straggler stars and FK Com-type stars are unsolved problems in stellar astrophysics. One of the possible explanations for their formation is from the coalescence of W UMa-type overcontact binary systems. The absolute dimensions of ASAS 021209+2708.3 are estimated and its dynamical evolution is inferred.

Acerbi, Francesco; Barani, Carlo; Martignoni, Massimiliano

2011-07-01

460

Environmental differences in substrate mechanics do not affect sprinting performance in sand lizards (Uma scoparia and Callisaurus draconoides).  

PubMed

Running performance depends on a mechanical interaction between the feet of an animal and the substrate. This interaction may differ between two species of sand lizard from the Mojave Desert that have different locomotor morphologies and habitat distributions. Uma scorparia possesses toe fringes and inhabits dunes, whereas the closely related Callisaurus draconoides lacks fringes and is found on dune and wash habitats. The present study evaluated whether these distribution patterns are related to differential locomotor performance on the fine sand of the dunes and the course sand of the wash habitat. We measured the kinematics of sprinting and characterized differences in grain size distribution and surface strength of the soil in both habitats. Although wash sand had a surface strength (15.4±6.2 kPa) that was more than three times that of dune sand (4.7±2.1 kPa), both species ran with similar sprinting performance on the two types of soil. The broadly distributed C. draconoides ran with a slightly (22%) faster maximum speed (2.2±0.2 m s(-1)) than the dune-dwelling U. scorparia (1.8±0.2 m s(-1)) on dune sand, but not on wash sand. Furthermore, there were no significant differences in maximum acceleration or the time to attain maximum speed between species or between substrates. These results suggest that differences in habitat distribution between these species are not related to locomotor performance and that sprinting ability is dominated neither by environmental differences in substrate nor the presence of toe fringes. PMID:21147976

Korff, Wyatt L; McHenry, Matthew J

2011-01-01

461

Ambient air quality effects of the 2008-2009 Halema`uma`u eruption on the Island of Hawai`i  

Microsoft Academic Search

While the Halema`uma`u eruption has enlivened volcanologists with the rare opportunity to observe eruptive processes at Kilauea's summit, it has also caused significant environmental impact on the Island of Hawai`i. Since the beginning of 2008, the combined SO2 emissions from the east rift zone (ERZ) and summit of Kilauea have increased by ~40% as compared to the 2003-2007 long-term average.

T. Elias; A. J. Sutton; J. P. Kauahikaua; J. D. Ray; J. L. Babb

2009-01-01

462

Volatiles in gases and melt inclusions erupted during the 2008-9 Halema`uma`u eruption of Kilauea Volcano, Hawai`i  

Microsoft Academic Search

Parental magmas ascending beneath Kilauea Volcano degas volatile species in the order of their solubility, with deep degassing (up to a few tens of kilometres depth) dominated by carbon dioxide and shallow degassing (less than 1 km depth), by water and sulphur gases. The 2008-9 Halema`uma`u eruption provides a unique opportunity to measure the composition of primary, unfractionated volcanic gas

G. M. Sawyer; I. Sides; R. Martin; I. Mead; T. J. Roberts; R. Jones; V. I. Tsanev; R. Herd; A. J. Sutton; T. Elias; C. A. Werner; D. Swanson; P. Allard; C. Oppenheimer; M. Edmonds

2009-01-01

463

EMS Stretcher "Misadventures" in a Large, Urban EMS System: A Descriptive Analysis of Contributing Factors and Resultant Injuries.  

PubMed

Purpose. There is a paucity of data regarding EMS stretcher-operation-related injuries. This study describes and analyzes characteristics associated with undesirable stretcher operations, with or without resultant injury in a large, urban EMS agency. Methods. In the study agency, all stretcher-related "misadventures" are required to be documented, regardless of whether injury results. All stretcher-related reports between July 1, 2009 and June 30, 2010 were queried in retrospective analysis, avoiding Hawthorne effect in stretcher operations. Results. During the year studied, 129,110 patients were transported. 23 stretcher incidents were reported (0.16 per 1,000 transports). No patient injury occurred. Four EMS providers sustained minor injuries. Among contributing aspects, the most common involved operations surrounding the stretcher-ambulance safety latch, 14/23 (60.9%). From a personnel injury prevention perspective, there exists a significant relationship between combative patients and crew injury related to stretcher operation, Fisher's exact test 0.048. Conclusions. In this large, urban EMS system, the incidence of injury related to stretcher operations in the one-year study period is markedly low, with few personnel injuries and no patient injuries incurred. Safety for EMS personnel and patients could be advanced by educational initiatives that highlight specific events and conditions contributing to stretcher-related adverse events. PMID:22606379

Goodloe, Jeffrey M; Crowder, Christopher J; Arthur, Annette O; Thomas, Stephen H

2012-01-01

464

EMS Stretcher “Misadventures” in a Large, Urban EMS System: A Descriptive Analysis of Contributing Factors and Resultant Injuries  

PubMed Central

Purpose. There is a paucity of data regarding EMS stretcher-operation-related injuries. This study describes and analyzes characteristics associated with undesirable stretcher operations, with or without resultant injury in a large, urban EMS agency. Methods. In the study agency, all stretcher-related “misadventures” are required to be documented, regardless of whether injury results. All stretcher-related reports between July 1, 2009 and June 30, 2010 were queried in retrospective analysis, avoiding Hawthorne effect in stretcher operations. Results. During the year studied, 129,110 patients were transported. 23 stretcher incidents were reported (0.16 per 1,000 transports). No patient injury occurred. Four EMS providers sustained minor injuries. Among contributing aspects, the most common involved operations surrounding the stretcher-ambulance safety latch, 14/23 (60.9%). From a personnel injury prevention perspective, there exists a significant relationship between combative patients and crew injury related to stretcher operation, Fisher's exact test 0.048. Conclusions. In this large, urban EMS system, the incidence of injury related to stretcher operations in the one-year study period is markedly low, with few personnel injuries and no patient injuries incurred. Safety for EMS personnel and patients could be advanced by educational initiatives that highlight specific events and conditions contributing to stretcher-related adverse events. PMID:22606379

Goodloe, Jeffrey M.; Crowder, Christopher J.; Arthur, Annette O.; Thomas, Stephen H.

2012-01-01

465

Analyses of Subnanometer Resolution Cryo-EM Density Maps  

PubMed Central

Today, electron cryomicroscopy (cryo-EM) can routinely achieve subnanometer resolutions of complex macromolecular assemblies. From a density map, one can extract key structural and functional information using a variety of computational analysis tools. At subnanometer resolution, these tools make it possible to isolate individual subunits, identify secondary structures, and accurately fit atomic models. With several cryo-EM studies achieving resolutions beyond 5 Å, computational modeling and feature recognition tools have been employed to construct backbone and atomic models of the protein components directly from a density map. In this chapter, we describe several common classes of computational tools that can be used to analyze and model subnanometer resolution reconstructions from cryo-EM. A general protocol for analyzing subnanometer resolution density maps is presented along with a full description of steps used in analyzing the 4.3 Å resolution structure of Mm-cpn. PMID:20888467

Baker, Matthew L.; Baker, Mariah R.; Hryc, Corey F.; DiMaio, Frank

2011-01-01

466

Residual Symmetries in the Presence of an EM Background  

E-print Network

The symmetry algebra of a QFT in the presence of an external EM background (named "residual symmetry") is investigated within a Lie-algebraic, model independent scheme. Some results previously encountered in the literature are here extended. In particular we compute the symmetry algebra for a constant EM background in D=3 and D=4 dimensions. In D= 3 dimensions the residual symmetry algebra is isomorphic to $u(1)\\oplus {\\cal P}_c(2)$, with ${\\cal P}_c(2)$ the centrally extended 2-dimensional Poincar\\'e algebra. In D=4 dimension the generic residual symmetry algebra is given by a seven-dimensional solvable Lie algebra which is explicitly computed. Residual symmetry algebras are also computed for specific non-constant EM backgrounds.

H. L. Carrion; M. Rojas; F. Toppan

2002-05-23

467

Convergence Results for the EM Approach to Mixtures of Experts Architectures  

E-print Network

The Expectation-Maximization (EM) algorithm is an iterative approach to maximum likelihood parameter estimation. Jordan and Jacobs (1993) recently proposed an EM algorithm for the mixture of experts architecture of ...

Jordan, Michael I.

1993-11-01

468

Estudo de apomixia em diferentes níveis de ploidia no Manihot spp.  

E-print Network

??Dissertação (mestrado)—Universidade de Brasília, Instituto de Ciências Biológicas, Departamento de Botânica, Programa de Pós-Graduação em Botânica, 2011. A apomixia em Manihot vem sendo estudada pelo… (more)

Ferreira, Adalgisa Maria Chaib

2011-01-01

469

EM-31 Alternative and Enhanced Chemical Cleaning Program  

SciTech Connect

King's introduction to his presentation made 5 important points: 1) Numerous SRS tanks scheduled for closure (contract commitments); 2) Cannot remove all sludge by mechanical means due to obstructions; 3) Chemical removal technology needed (likely oxalic acid); 4) Post - dissolution neutralization required prior to transfer to compliant tanks; 5) Sodium oxalate salts precipitate on neutralization and have negative downstream impacts. There were three SRS chemical cleaning programs in 2010: Baseline: 8wt percent OA batch contact, ECC: 1-3 wt. percent OA with oxalate destruction, and the Alternative/Enhanced Chemical Cleaning (EM-31). This talk is on the EM-31 program.

King, Bill (SRNL) [SRNL

2010-11-01

470

ARTIGO INTERNET Jogos Srios em debate no IST  

E-print Network

ARTIGO INTERNET «Jogos Sérios» em debate no IST in http://sol.sapo.pt/ Data: 2011-9-15 Link: http://sol.sapo.pt/inicio/Tecn ... «Jogos Sérios» em debate no IST O Instituto Superior Técnico (IST) vai ser o palco da II Conferência Internacional sobre aplicações e desenvolvimento de «Jogos Sérios» A conferência terá lugar nos dias 19 e 20 de

Instituto de Sistemas e Robotica

471

MESTRADO EM MICROBIOLOGIA EPIDEMIOLOGIA DE DOENAS TRANSMISSVEIS Faculdade de Cincias  

E-print Network

transmissíveis (DTs) e agentes etiológicos. História natural da infecção no hospedeiro. Noção de R0. Imunidade de grupo. Construção de modelos matemáticos para DTs: em equações às diferenças. Principais parâmetros dos modelos de DTs e sua estimação. Modelos para DTs formalizados em equações diferenciais. Padrões dinâmicos

Instituto de Sistemas e Robotica

472

Erros comuns de ingls em artigos cientficos escritos por pessoas de lngua portuguesa  

E-print Network

Erros comuns de inglês em artigos científicos escritos por pessoas de língua portuguesa Siang Wun comuns de inglês em artigos científicos escritos por pessoa #12;Introdução Baseado em experiência acumulada ao longo dos anos, ao revisar artigos escritos em inglês principalmente por pessoas de língua

Song, Siang Wun

473

Study on the Temperature Limitation of the Injecting Power to a Pyramidal EM-Wave Absorber  

Microsoft Academic Search

In this paper, first the temperature distribution of the pyramidal EM-wave absorber is calculated in the coupled method. Next, the injected power to the EM-wave absorber is changed to estimate the maximum power density that the EM-wave absorber can resist. As a result, the limitation of the injecting power density to a pyramidal EM-wave absorber is achievable.

Tetsuhiro Sasagawa; Shinya Watanabe; Osamu Hashimoto; Toshifumi Saito; Hiroshi Kurihara

2009-01-01

474

Quasi-Monte Carlo Sampling to improve the Efficiency of Monte Carlo EM  

E-print Network

Quasi-Monte Carlo Sampling to improve the Efficiency of Monte Carlo EM Wolfgang Jank Department@rhsmith.umd.edu November 17, 2003 Abstract In this paper we investigate an efficient implementation of the Monte Carlo EM al- gorithm based on Quasi-Monte Carlo sampling. The Monte Carlo EM algorithm is a stochastic version

Jank, Wolfgang