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Sample records for precise tightly size-calibrated

  1. Tightly Coupled Integration of Ionosphere-Constrained Precise Point Positioning and Inertial Navigation Systems

    PubMed Central

    Gao, Zhouzheng; Zhang, Hongping; Ge, Maorong; Niu, Xiaoji; Shen, Wenbin; Wickert, Jens; Schuh, Harald

    2015-01-01

    The continuity and reliability of precise GNSS positioning can be seriously limited by severe user observation environments. The Inertial Navigation System (INS) can overcome such drawbacks, but its performance is clearly restricted by INS sensor errors over time. Accordingly, the tightly coupled integration of GPS and INS can overcome the disadvantages of each individual system and together form a new navigation system with a higher accuracy, reliability and availability. Recently, ionosphere-constrained (IC) precise point positioning (PPP) utilizing raw GPS observations was proven able to improve both the convergence and positioning accuracy of the conventional PPP using ionosphere-free combined observations (LC-PPP). In this paper, a new mode of tightly coupled integration, in which the IC-PPP instead of LC-PPP is employed, is implemented to further improve the performance of the coupled system. We present the detailed mathematical model and the related algorithm of the new integration of IC-PPP and INS. To evaluate the performance of the new tightly coupled integration, data of both airborne and vehicle experiments with a geodetic GPS receiver and tactical grade inertial measurement unit are processed and the results are analyzed. The statistics show that the new approach can further improve the positioning accuracy compared with both IC-PPP and the tightly coupled integration of the conventional PPP and INS. PMID:25763647

  2. Tightly coupled integration of ionosphere-constrained precise point positioning and inertial navigation systems.

    PubMed

    Gao, Zhouzheng; Zhang, Hongping; Ge, Maorong; Niu, Xiaoji; Shen, Wenbin; Wickert, Jens; Schuh, Harald

    2015-01-01

    The continuity and reliability of precise GNSS positioning can be seriously limited by severe user observation environments. The Inertial Navigation System (INS) can overcome such drawbacks, but its performance is clearly restricted by INS sensor errors over time. Accordingly, the tightly coupled integration of GPS and INS can overcome the disadvantages of each individual system and together form a new navigation system with a higher accuracy, reliability and availability. Recently, ionosphere-constrained (IC) precise point positioning (PPP) utilizing raw GPS observations was proven able to improve both the convergence and positioning accuracy of the conventional PPP using ionosphere-free combined observations (LC-PPP). In this paper, a new mode of tightly coupled integration, in which the IC-PPP instead of LC-PPP is employed, is implemented to further improve the performance of the coupled system. We present the detailed mathematical model and the related algorithm of the new integration of IC-PPP and INS. To evaluate the performance of the new tightly coupled integration, data of both airborne and vehicle experiments with a geodetic GPS receiver and tactical grade inertial measurement unit are processed and the results are analyzed. The statistics show that the new approach can further improve the positioning accuracy compared with both IC-PPP and the tightly coupled integration of the conventional PPP and INS. PMID:25763647

  3. Application of Phase Smoothing Pseudo Range PPP/INS Tightly Coupled Technique in Improving the Results of Low Precision MEMS

    NASA Astrophysics Data System (ADS)

    Luo, X.

    2015-12-01

    In land surveying and engineering surveying, we need to obtain high precision navigation results. However, due to the inertial device costs less than a introduction, commonly used low precision inertial navigation equipment with tightly coupled GPS / INS integrated to get high precision navigation results. Many studies have improved the accuracy of error by using the UKF and CKF filtering algorithm, but it is still using the traditional pseudo code directly, the improvement effect is not obvious, and the disturbance is large. In this study, the PPP /INSmodel is improved by using the carrier phase smoothing pseudo range algorithm. Experimental results show that based on phase smoothing pseudo range PPP/INS tight coupled method, the position precision and the velocity precision for of the measured data of higher accuracy of MEMS and GPS receiver can get to a decimeter level and centimeter level. This coupling method has higher accuracy, stronger anti disturbance and Have a better convergence than the traditional C/A code. Based on different phase smoothing epoch number combination the accuracy and smoothing effect is also different, the larger smooth epoch number is, the better treatment effect it has and The higher precision it has. For high precision measurement, the equipment cost is saved. It has a practical significance meaning in the measurement of outdoor ground.

  4. Sample-Wise Aiding in GPS/INS Ultra-Tight Integration for High-Dynamic, High-Precision Tracking.

    PubMed

    Kou, Yanhong; Zhang, Han

    2016-01-01

    By aiding GPS receiver tracking loops with INS estimates of signal dynamics, GPS/INS ultra-tight coupling can improve the navigation performance in challenging environments. Traditionally the INS data are injected into the loops once every loop update interval, which limits the levels of dynamics accommodated. This paper presents a sample-wise aiding method, which interpolates the aiding Doppler into each digital sample of the local signal to further eliminate the dynamic errors. The relationship between the tracking error and the aiding rate is derived analytically. Moreover, the effects of sample-wise aiding using linear and spline interpolations are simulated and compared with traditional aiding under different INS data update rates. Finally, extensive tests based on a digital IF (intermediate frequency) signal simulator and a software receiver validate the theoretical equations and demonstrate that the dynamic stress error can be significantly reduced by sample-wise aiding. PMID:27077858

  5. Sample-Wise Aiding in GPS/INS Ultra-Tight Integration for High-Dynamic, High-Precision Tracking

    PubMed Central

    Kou, Yanhong; Zhang, Han

    2016-01-01

    By aiding GPS receiver tracking loops with INS estimates of signal dynamics, GPS/INS ultra-tight coupling can improve the navigation performance in challenging environments. Traditionally the INS data are injected into the loops once every loop update interval, which limits the levels of dynamics accommodated. This paper presents a sample-wise aiding method, which interpolates the aiding Doppler into each digital sample of the local signal to further eliminate the dynamic errors. The relationship between the tracking error and the aiding rate is derived analytically. Moreover, the effects of sample-wise aiding using linear and spline interpolations are simulated and compared with traditional aiding under different INS data update rates. Finally, extensive tests based on a digital IF (intermediate frequency) signal simulator and a software receiver validate the theoretical equations and demonstrate that the dynamic stress error can be significantly reduced by sample-wise aiding. PMID:27077858

  6. Tightly Coupled Integration of GPS Ambiguity Fixed Precise Point Positioning and MEMS-INS through a Troposphere-Constrained Adaptive Kalman Filter

    PubMed Central

    Han, Houzeng; Xu, Tianhe; Wang, Jian

    2016-01-01

    Precise Point Positioning (PPP) makes use of the undifferenced pseudorange and carrier phase measurements with ionospheric-free (IF) combinations to achieve centimeter-level positioning accuracy. Conventionally, the IF ambiguities are estimated as float values. To improve the PPP positioning accuracy and shorten the convergence time, the integer phase clock model with between-satellites single-difference (BSSD) operation is used to recover the integer property. However, the continuity and availability of stand-alone PPP is largely restricted by the observation environment. The positioning performance will be significantly degraded when GPS operates under challenging environments, if less than five satellites are present. A commonly used approach is integrating a low cost inertial sensor to improve the positioning performance and robustness. In this study, a tightly coupled (TC) algorithm is implemented by integrating PPP with inertial navigation system (INS) using an Extended Kalman filter (EKF). The navigation states, inertial sensor errors and GPS error states are estimated together. The troposphere constrained approach, which utilizes external tropospheric delay as virtual observation, is applied to further improve the ambiguity-fixed height positioning accuracy, and an improved adaptive filtering strategy is implemented to improve the covariance modelling considering the realistic noise effect. A field vehicular test with a geodetic GPS receiver and a low cost inertial sensor was conducted to validate the improvement on positioning performance with the proposed approach. The results show that the positioning accuracy has been improved with inertial aiding. Centimeter-level positioning accuracy is achievable during the test, and the PPP/INS TC integration achieves a fast re-convergence after signal outages. For troposphere constrained solutions, a significant improvement for the height component has been obtained. The overall positioning accuracies of the height

  7. Tightly Coupled Integration of GPS Ambiguity Fixed Precise Point Positioning and MEMS-INS through a Troposphere-Constrained Adaptive Kalman Filter.

    PubMed

    Han, Houzeng; Xu, Tianhe; Wang, Jian

    2016-01-01

    Precise Point Positioning (PPP) makes use of the undifferenced pseudorange and carrier phase measurements with ionospheric-free (IF) combinations to achieve centimeter-level positioning accuracy. Conventionally, the IF ambiguities are estimated as float values. To improve the PPP positioning accuracy and shorten the convergence time, the integer phase clock model with between-satellites single-difference (BSSD) operation is used to recover the integer property. However, the continuity and availability of stand-alone PPP is largely restricted by the observation environment. The positioning performance will be significantly degraded when GPS operates under challenging environments, if less than five satellites are present. A commonly used approach is integrating a low cost inertial sensor to improve the positioning performance and robustness. In this study, a tightly coupled (TC) algorithm is implemented by integrating PPP with inertial navigation system (INS) using an Extended Kalman filter (EKF). The navigation states, inertial sensor errors and GPS error states are estimated together. The troposphere constrained approach, which utilizes external tropospheric delay as virtual observation, is applied to further improve the ambiguity-fixed height positioning accuracy, and an improved adaptive filtering strategy is implemented to improve the covariance modelling considering the realistic noise effect. A field vehicular test with a geodetic GPS receiver and a low cost inertial sensor was conducted to validate the improvement on positioning performance with the proposed approach. The results show that the positioning accuracy has been improved with inertial aiding. Centimeter-level positioning accuracy is achievable during the test, and the PPP/INS TC integration achieves a fast re-convergence after signal outages. For troposphere constrained solutions, a significant improvement for the height component has been obtained. The overall positioning accuracies of the height

  8. Tight bag

    PubMed Central

    Parthasarathy, S; Ravishankar, M

    2010-01-01

    Tight bag is a clinical situation where excessive pressure needs to be applied to a reservoir bag of a breathing system to an intubated patient, which may or may not produce satisfactory ventilation. The various clinical scenarios and the appropriate steps for its prevention are described. PMID:20885863

  9. Tight Diabetes Control

    MedlinePlus

    ... Size: A A A Listen En Español Tight Diabetes Control Keeping your blood glucose levels as close ... and syringes, than before. What About Type 2 Diabetes? The DCCT studied only people with type 1 ...

  10. Complex equiangular tight frames

    NASA Astrophysics Data System (ADS)

    Tropp, Joel A.

    2005-08-01

    A complex equiangular tight frame (ETF) is a tight frame consisting of N unit vectors in Cd whose absolute inner products are identical. One may view complex ETFs as a natural geometric generalization of an orthonormal basis. Numerical evidence suggests that these objects do not arise for most pairs (d, N). The goal of this paper is to develop conditions on (d, N) under which complex ETFs can exist. In particular, this work concentrates on the class of harmonic ETFs, in which the components of the frame vectors are roots of unity. In this case, it is possible to leverage field theory to obtain stringent restrictions on the possible values for (d, N).

  11. Tight bifunctional hierarchical catalyst.

    PubMed

    Højholt, Karen T; Vennestrøm, Peter N R; Tiruvalam, Ramchandra; Beato, Pablo

    2011-12-28

    A new concept to prepare tight bifunctional catalysts has been developed, by anchoring CoMo(6) clusters on hierarchical ZSM-5 zeolites for simultaneous use in HDS and hydrocracking catalysis. The prepared material displays a significant improved activity in HDS catalysis compared to the impregnated counterpart. PMID:22048337

  12. Tight Binding Models in Cold Atoms Physics

    NASA Astrophysics Data System (ADS)

    Zakrzewski, J.

    2007-05-01

    Cold atomic gases placed in optical lattice potentials offer a unique tool to study simple tight binding models. Both the standard cases known from the condensed matter theory as well as novel situations may be addressed. Cold atoms setting allows for a precise control of parameters of the systems discussed, stimulating new questions and problems. The attempts to treat disorder in a controlled fashion are addressed in detail.

  13. Tight Junctions Go Viral!

    PubMed Central

    Torres-Flores, Jesús M.; Arias, Carlos F.

    2015-01-01

    Tight junctions (TJs) are highly specialized membrane domains involved in many important cellular processes such as the regulation of the passage of ions and macromolecules across the paracellular space and the establishment of cell polarity in epithelial cells. Over the past few years there has been increasing evidence that different components of the TJs can be hijacked by viruses in order to complete their infectious cycle. Viruses from at least nine different families of DNA and RNA viruses have been reported to use TJ proteins in their benefit. For example, TJ proteins such as JAM-A or some members of the claudin family of proteins are used by members of the Reoviridae family and hepatitis C virus as receptors or co-receptors during their entry into their host cells. Reovirus, in addition, takes advantage of the TJ protein Junction Adhesion Molecule-A (JAM-A) to achieve its hematogenous dissemination. Some other viruses are capable of regulating the expression or the localization of TJ proteins to induce cell transformation or to improve the efficiency of their exit process. This review encompasses the importance of TJs for viral entry, replication, dissemination, and egress, and makes a clear statement of the importance of studying these proteins to gain a better understanding of the replication strategies used by viruses that infect epithelial and/or endothelial cells. PMID:26404354

  14. Diagnosing the tight building syndrome.

    PubMed Central

    Rogers, S A

    1987-01-01

    Formaldehyde is but one of many chemicals capable of causing the tight building syndrome or environmentally induced illness (EI). The spectrum of symptoms it may induce includes attacks of headache, flushing, laryngitis, dizziness, nausea, extreme weakness, arthralgia, unwarranted depression, dysphonia, exhaustion, inability to think clearly, arrhythmia or muscle spasms. The nonspecificity of such symptoms can baffle physicians from many specialties. Presented herein is a simple office method for demonstrating that formaldehyde is among the etiologic agents triggering these symptoms. The very symptoms that patients complain of can be provoked within minutes, and subsequently abolished, with an intradermal injection of the appropriate strength of formaldehyde. This injection aids in convincing the patient of the cause of the symptoms so he can initiate measures to bring his disease under control. PMID:3447898

  15. Diagnosing the tight building syndrome

    SciTech Connect

    Rogers, S.A.

    1987-12-01

    Formaldehyde is but one of many chemicals capable of causing the tight building syndrome or environmentally induced illness (EI). The spectrum of symptoms it may induce includes attacks of headache, flushing, laryngitis, dizziness, nausea, extreme weakness, arthralgia, unwarranted depression, dysphonia, exhaustion, inability to think clearly, arrhythmia or muscle spasms. The nonspecificity of such symptoms can baffle physicians from many specialties. Presented herein is a simple office method for demonstrating that formaldehyde is among the etiologic agents triggering these symptoms. The very symptoms that patients complain of can be provoked within minutes, and subsequently abolished, with an intradermal injection of the appropriate strength of formaldehyde. This injection aids in convincing the patient of the cause of the symptoms so he can initiate measure to bring his disease under control.

  16. Historical development of tight formation gas

    SciTech Connect

    Rosenberg, J.I.; Haas, M.R.

    1986-01-01

    The unproven recoverable resource base of tight gas, irrespective of technology or price, was estimated by the National Petroleum Council (NPC) to be on the order of 600 Tcf as of the beginning of 1980. The NPC also estimated an additional 12 Tcf of proven tight gas reserves in the lower-48 states. Gas Research Institute (GRI) has supported the creation of a tight gas production data base to update the NPC study and to assess the historical development of this resource and its implications for future recovery. The major findings of this study include the following points: (1) total tight gas production almost doubled over the period from 1970 through 1981, reaching a peak of 1.4 Tcf, or about 9% of total nonassociated gas production. Declining production activity among many gas sources since then has reduced the annual contribution of tight gas to between 1.0 and 1.2 Tcf in 1984; (2) the tight gas resource is substantially intermingled with higher permeability formations and, as compared with non-tight gas resources, is much less often found as a result of new exploration activity; (3) the size distribution of tight gas fields is skewed more toward smaller field sizes than are the distributions of mixed fields (i.e., including production from tight and non-tight formations) or exclusively non-tight fields; (4) between 17 and 27 Tcf of proved reserves were estimated to remain as of the beginning of 1983 from previously discovered tight gas fields in three Rocky Mountains states (Colorado, Wyoming, and Utah), much of Texas, and the San Juan basin (mainly western New Mexico). The Appalachian basin includes another 3 to 4 Tcf of remaining tight gas reserves. Total tight gas reserves represent up to half of the nonassociated gas reserves estimated to remain in the above areas. 9 references.

  17. Biochemical and biophysical analyses of tight junction permeability made of claudin-16 and claudin-19 dimerization

    PubMed Central

    Gong, Yongfeng; Renigunta, Vijayaram; Zhou, Yi; Sunq, Abby; Wang, Jinzhi; Yang, Jing; Renigunta, Aparna; Baker, Lane A.; Hou, Jianghui

    2015-01-01

    The molecular nature of tight junction architecture and permeability is a long-standing mystery. Here, by comprehensive biochemical, biophysical, genetic, and electron microscopic analyses of claudin-16 and -19 interactions—two claudins that play key polygenic roles in fatal human renal disease, FHHNC—we found that 1) claudin-16 and -19 form a stable dimer through cis association of transmembrane domains 3 and 4; 2) mutations disrupting the claudin-16 and -19 cis interaction increase tight junction ultrastructural complexity but reduce tight junction permeability; and 3) no claudin hemichannel or heterotypic channel made of claudin-16 and -19 trans interaction can exist. These principles can be used to artificially alter tight junction permeabilities in various epithelia by manipulating selective claudin interactions. Our study also emphasizes the use of a novel recording approach based on scanning ion conductance microscopy to resolve tight junction permeabilities with submicrometer precision. PMID:26446843

  18. Air tightness of buildings in Finland

    NASA Astrophysics Data System (ADS)

    Kauppinen, Timo T.

    2001-03-01

    There are no requirements of building air tightness in Finland. Buildings always have thermal bridges and air leak routes, whose impact in decreasing comfort depends on the structures and the way of constructing. Uncontrolled air leaks are cooling the structures and causing draft and, in the long run, defects. These air leaks and thermal bridges can be found only by thermal scanning. In Finland building air tightness has been measured for over 20 years. The procedure includes two stages, in which the target is scanned by a thermal imager. The paper is based on the results of over 200 tests of one-family and detached houses. The air tightness level has improved, but there are still problems in the structural details. The monitoring procedure for therm scanning of buildings should be further developed (there is no generally accepted practice at the moment), as well as air tightness requirements should be created.

  19. Exercise regulation of intestinal tight junction proteins.

    PubMed

    Zuhl, Micah; Schneider, Suzanne; Lanphere, Katherine; Conn, Carole; Dokladny, Karol; Moseley, Pope

    2014-06-01

    Gastrointestinal distress, such as diarrhoea, cramping, vomiting, nausea and gastric pain are common among athletes during training and competition. The mechanisms that cause these symptoms are not fully understood. The stress of heat and oxidative damage during exercise causes disruption to intestinal epithelial cell tight junction proteins resulting in increased permeability to luminal endotoxins. The endotoxin moves into the blood stream leading to a systemic immune response. Tight junction integrity is altered by the phosphoylation state of the proteins occludin and claudins, and may be regulated by the type of exercise performed. Prolonged exercise and high-intensity exercise lead to an increase in key phosphorylation enzymes that ultimately cause tight junction dysfunction, but the mechanisms are different. The purpose of this review is to (1) explain the function and physiology of tight junction regulation, (2) discuss the effects of prolonged and high-intensity exercise on tight junction permeability leading to gastrointestinal distress and (3) review agents that may increase or decrease tight junction integrity during exercise. PMID:23134759

  20. Precision translator

    DOEpatents

    Reedy, Robert P.; Crawford, Daniel W.

    1984-01-01

    A precision translator for focusing a beam of light on the end of a glass fiber which includes two turning fork-like members rigidly connected to each other. These members have two prongs each with its separation adjusted by a screw, thereby adjusting the orthogonal positioning of a glass fiber attached to one of the members. This translator is made of simple parts with capability to keep adjustment even in condition of rough handling.

  1. Precision translator

    DOEpatents

    Reedy, R.P.; Crawford, D.W.

    1982-03-09

    A precision translator for focusing a beam of light on the end of a glass fiber which includes two turning fork-like members rigidly connected to each other. These members have two prongs each with its separation adjusted by a screw, thereby adjusting the orthogonal positioning of a glass fiber attached to one of the members. This translator is made of simple parts with capability to keep adjustment even in condition of rough handling.

  2. Current trends in salivary gland tight junctions.

    PubMed

    Baker, Olga J

    2016-01-01

    Tight junctions form a continuous intercellular barrier between epithelial cells that is required to separate tissue spaces and regulate selective movement of solutes across the epithelium. They are composed of strands containing integral membrane proteins (e.g., claudins, occludin and tricellulin, junctional adhesion molecules and the coxsackie adenovirus receptor). These proteins are anchored to the cytoskeleton via scaffolding proteins such as ZO-1 and ZO-2. In salivary glands, tight junctions are involved in polarized saliva secretion and barrier maintenance between the extracellular environment and the glandular lumen. This review seeks to provide an overview of what is currently known, as well as the major questions and future research directions, regarding tight junction expression, organization and function within salivary glands. PMID:27583188

  3. Keeping Schools Safe during Tight Budget Times

    ERIC Educational Resources Information Center

    Trump, Kenneth S.

    2010-01-01

    Tight budgets are no excuse for failing to be proactive with school safety. In fact, school leaders must be especially committed to prevention and security programs during times when economic woes are increasing stress on kids, their families and school staff. Parents will forgive educators if their school's test scores drop. But they are much…

  4. The tight junction: a multifunctional complex.

    PubMed

    Schneeberger, Eveline E; Lynch, Robert D

    2004-06-01

    Multicellular organisms are separated from the external environment by a layer of epithelial cells whose integrity is maintained by intercellular junctional complexes composed of tight junctions, adherens junctions, and desmosomes, whereas gap junctions provide for intercellular communication. The aim of this review is to present an updated overview of recent developments in the area of tight junction biology. In a relatively short time, our knowledge of the tight junction has evolved from a relatively simple view of it being a permeability barrier in the paracellular space and a fence in the plane of the plasma membrane to one of it acting as a multicomponent, multifunctional complex that is involved in regulating numerous and diverse cell functions. A group of integral membrane proteins-occludin, claudins, and junction adhesion molecules-interact with an increasingly complex array of tight junction plaque proteins not only to regulate paracellular solute and water flux but also to integrate such diverse processes as gene transcription, tumor suppression, cell proliferation, and cell polarity. PMID:15151915

  5. Tight junction, selective permeability, and related diseases.

    PubMed

    Krug, Susanne M; Schulzke, Jörg D; Fromm, Michael

    2014-12-01

    The tight junction forms a barrier against unlimited paracellular passage but some of the tight junction proteins just do the opposite, they form extracellular channels zigzagging between lateral membranes of neighboring cells. All of these channel-forming proteins and even some of the barrier formers exhibit selectivity, which means that they prefer certain substances over others. All channel formers exhibit at least one of the three types of selectivity: for cations (claudin-2, -10b, -15), for anions (claudin-10a, -17) or for water (claudin-2). Also some, but not all, barrier-forming claudins are charge-selective (claudin-4, -8, -14). Moreover, occludin and tricellulin turned out to be relevant for barrier formation against macromolecule passage. Tight junction proteins are dysregulated or can be genetically defective in numerous diseases, which may lead to three effects: (i) impaired paracellular transport e.g. causing magnesium loss in the kidney, (ii) increased paracellular transport of solutes and water e.g. causing leak-flux diarrhea in the intestine, and (iii) increased permeability to large molecules e.g. unwanted intestinal pathogen uptake fueling inflammatory processes. This review gives an overview on the properties of tight junction proteins featuring selective permeability, and in this context explains how these proteins induce or aggravate diseases. PMID:25220018

  6. Petrophysical approach of tight gas reservoir including shaly sand

    NASA Astrophysics Data System (ADS)

    Kim, Taeyoun; Hwang, Seho; Jang, Seonghyung

    2016-04-01

    Since porosity of tight gas reservoir is very small, it is very important to estimate porosity from well logs precisely. If well logging porosity is not appropriate or does not match with core-tested porosity, other rock properties related to porosity cannot be estimated correctly. In case of shaly sand, we have to consider clay volume for estimating water saturation and effective porosity. The purpose of this study is to address a process issue for estimating total porosity, water saturation of tight gas reservoir including shaly sand from well logs. The methods for estimating total porosity with difference well logging responses include neutron-density method, neutron-sonic method, density method, sonic method and compared with core-tested porosity. After calculating correlation coefficient between well logging total porosity and core-tested porosity, we select a best matched result. Using this result, we try to estimate water saturation from well logs. Normally, Archie's method is very famous for calculating water saturation. Since it assumes clean sand condition, we tried to apply other methods considering clay volume. In this study, we applied Archie's method, dual water method, and Indonesian method for estimating water saturation from well logs and compared with core-tested water saturation.

  7. Hormonal regulation of hepatocyte tight junctional permeability

    SciTech Connect

    Lowe, P.J.; Miyai, K.; Steinbach, J.H.; Hardison, W.G.M. Univ. of California, San Diego )

    1988-10-01

    The authors have investigated the effects of hormones on the permeability of the hepatocyte tight junction to two probes, ({sup 14}C)sucrose and horseradish peroxidase, using one-pass perfused rat livers. Using a single injection of horseradish peroxidase the authors have demonstrated that this probe can enter bile by two pathways that are kinetically distinct, a fast pathway, which corresponds to the passage of the probe through the hepatocyte tight junctions, and a slow pathway, which corresponds to the transcytotic entry into bile. The passage of horseradish peroxidase through the hepatocyte tight junctions was confirmed by electron microscopic histochemistry. Vasopressin, epinephrine, and angiotensin II, hormones that act in the hepatocyte through the intracellular mediators calcium, the inositol polyphosphates, and diacylglycerol, increased the bile-to-perfusion fluid ratio of ({sup 14}C)sucrose and the rapid entry of horseradish peroxidase into bile, indicating that the permeability of the tight junctions to these probes was increased. The effect of these hormones was dose dependent and in the cases of angiotensin II and epinephrine was inhibited by the specific inhibitors (Sar{sup 1},Thr{sup 8})angiotensin II and prazosin, respectively. Dibutyryl adenosine 3{prime},5{prime}-cyclic monophosphate did not affect the ({sup 14}C)sucrose bile-to-perfusion fluid ratio or the fast entry of horseradish peroxidase into bile. These results suggest that the hepatocyte tight junction can no longer be considered a static system of pores separating blood from bile. It is rather a dynamic barrier potentially capable of influencing the composition of the bile.

  8. Molecular organization of tricellular tight junctions.

    PubMed

    Furuse, Mikio; Izumi, Yasushi; Oda, Yukako; Higashi, Tomohito; Iwamoto, Noriko

    2014-01-01

    When the apicolateral border of epithelial cells is compared with a polygon, its sides correspond to the apical junctional complex, where cell adhesion molecules assemble from the plasma membranes of two adjacent cells. On the other hand, its vertices correspond to tricellular contacts, where the corners of three cells meet. Vertebrate tricellular contacts have specialized structures of tight junctions, termed tricellular tight junctions (tTJs). tTJs were identified by electron microscopic observations more than 40 years ago, but have been largely forgotten in epithelial cell biology since then. The identification of tricellulin and angulin family proteins as tTJ-associated membrane proteins has enabled us to study tTJs in terms of not only the paracellular barrier function but also unknown characteristics of epithelial cell corners via molecular biological approaches. PMID:25097825

  9. Naturally fractured tight gas reservoir detection optimization

    SciTech Connect

    1998-09-30

    During this quarter, work began on the regional structural and geologic analysis of the greater Green River basin (GGRB) in southwestern Wyoming, northwestern Colorado and northeastern Utah. The ultimate objective of the regional analysis is to apply the techniques developed and demonstrated during earlier phases of the project to sweet-spot delineation in a relatively new and underexplored play: tight gas from continuous-type Upper Cretaceous reservoirs of the GGRB. The primary goal of this work is to partition and high-grade the greater Green River basin for exploration efforts in the Cretaceous tight gas play. The work plan for the quarter of January 1, 1998--March 31, 1998 consisted of three tasks: (1) Acquire necessary data and develop base map of study area; (2) Process data for analysis; and (3) Initiate structural study. The first task and second tasks were completed during this reporting period. The third task was initiated and work continues.

  10. Naturally fractured tight gas reservoir detection optimization

    SciTech Connect

    1998-11-30

    The goal of the work this quarter has been to partition and high-grade the Greater Green River basin for exploration efforts in the Upper Cretaceous tight gas play and to initiate resource assessment of the basin. The work plan for the quarter of July 1-September 30, 1998 comprised three tasks: (1) Refining the exploration process for deep, naturally fractured gas reservoirs; (2) Partitioning of the basin based on structure and areas of overpressure; (3) Examination of the Kinney and Canyon Creek fields with respect to the Cretaceous tight gas play and initiation of the resource assessment of the Vermilion sub-basin partition (which contains these two fields); and (4) Initiation analysis of the Deep Green River Partition with respect to the Stratos well and assessment of the resource in the partition.

  11. Tight dual models of pore spaces

    NASA Astrophysics Data System (ADS)

    Glantz, Roland; Hilpert, Markus

    2008-05-01

    The pore throats in a porous medium control permeability, drainage, and straining through their pore scale geometry and through the way they are connected via pore bodies on the macroscale. Likewise, imbibition is controlled through the geometry of the pore bodies (pore scale) and through the way the pore bodies are connected via pore throats on the macroscale. In an effort to account for both scales at the same time we recently introduced an image-based model for pore spaces that consists of two parts related by duality: (1) a decomposition of a polyhedral pore space into polyhedral pore bodies separated by polygonal pore throats and (2) a polygonal pore network that is homotopy equivalent to the pore space. In this paper we stick to the dual concept while amending the definition of the pore throats and, as a consequence, the other elements of the dual model. Formerly, the pore throats consisted of single two-dimensional Delaunay cells, while they now usually consist of more than one two-dimensional Delaunay cell and extend all the way into the narrowing ends of the pore channel cross sections. This is the first reason for naming the amended dual model "tight". The second reason is that the formation of the pore throats is now guided by an objective function that always attains its global optimum (tight optimization). At the end of the paper we report on simulations of drainage performed on tight dual models derived from simulated sphere packings and 3D gray-level images. The C-code for the generation of the tight dual model and the simulation of drainage is publicly available at https://jshare.johnshopkins.edu/mhilper1/public_html/tdm.html.

  12. Naturally fractured tight gas reservoir detection optimization

    SciTech Connect

    Decker, D.

    1995-05-01

    Exploration strategies are needed to identify subtle basement features critical to locating fractured regions in advance of drilling in tight gas reservoirs. The Piceance Basin served as a demonstration site for an analysis utilizing aeromagnetic surveys, remote sensing, Landsat Thematic Mapper, and Side Looking Airborne Radar imagery for the basin and surrounding areas. Spatially detailed aeromagnetic maps were used to to interpret zones of basement structure.

  13. Supplies tight for CFC-11 and -12

    SciTech Connect

    Rotman, D.; Kirschner, E.

    1992-09-30

    With US 1992 production of chlorofluorocarbon (CFC)-11 and -12 cut back to less than 50% of 1986 levels, supplies are tight and prices are rising. While CFC customers can find the product, the first half of the year was particularly bumpy, marked by shortages of key feedstock carbon tetrachloride. US carbon tet production dropped from 400 million lbs in 1991 to 250 million lbs because of a series of plant closings in 1991. The lack of carbon tet, says a spokesman for one CFC producer, was [open quotes]a real disruption.[close quotes] And, says Jerry Dziedzic, general manager, fluorochemicals at Elf Atochem (Philadelphia), in a such a tight market [open quotes]even a little hiccup can throw the system out of whack.[close quotes] Dow senior project manager Jeff Sullivan says CFC producers were expecting a drop in 1992 sales when the company's Sarnia, ON carbon tet plant closing was announced. By the time CFC producers recognized that demand would remain at 1991 levels, the shutdown was under way. [open quotes]We were caught short because they were caught short.[close quotes] While the carbon tet shortage has lessened recently, supplies of CFC-11 and 12 are expected to remain tight through the rest of the year. But that could ease toward year-end as hydrofluorocarbon-141b increasingly replaces CFC-11.

  14. Geologic characterization of tight gas reservoirs

    SciTech Connect

    Law, B.E.

    1990-12-01

    The objectives of US Geological Survey (USGS) work during FY 89 were to conduct geologic research characterizing tight gas-bearing sandstone reservoirs and their resources in the western United States. Our research has been regional in scope but, in some basins, our investigations have focused on single wells or small areas containing several wells where a large amount of data is available. The investigations, include structure, stratigraphy, petrography, x-ray mineralogy, source-rock evaluation, formation pressure and temperature, borehole geophysics, thermal maturity mapping, fission-track age dating, fluid-inclusion thermometry, and isotopic geochemistry. The objectives of these investigations are to provide geologic models that can be compared and utilized in tight gas-bearing sequences elsewhere. Nearly all of our work during FY 89 was devoted to developing a computer-based system for the Uinta basin and collecting, analyzing, and storage of data. The data base, when completed will contain various types of stratigraphic, organic chemistry, petrographic, production, engineering, and other information that relate to the petroleum geology of the Uinta basin, and in particular, to the tight gas-bearing strata. 16 refs., 3 figs.

  15. Epithelial tight junctions in intestinal inflammation.

    PubMed

    Schulzke, Joerg D; Ploeger, Svenja; Amasheh, Maren; Fromm, Anja; Zeissig, Sebastian; Troeger, Hanno; Richter, Jan; Bojarski, Christian; Schumann, Michael; Fromm, Michael

    2009-05-01

    The epithelium in inflamed intestinal segments of patients with Crohn's disease is characterized by a reduction of tight junction strands, strand breaks, and alterations of tight junction protein content and composition. In ulcerative colitis, epithelial leaks appear early due to micro-erosions resulting from upregulated epithelial apoptosis and in addition to a prominent increase of claudin-2. Th1-cytokine effects by interferon-gamma in combination with TNFalpha are important for epithelial damage in Crohn's disease, while interleukin-13 (IL-13) is the key effector cytokine in ulcerative colitis stimulating apoptosis and upregulation of claudin-2 expression. Focal lesions caused by apoptotic epithelial cells contribute to barrier disturbance in IBD by their own conductivity and by confluence toward apoptotic foci or erosions. Another type of intestinal barrier defect can arise from alpha-hemolysin harboring E. coli strains among the physiological flora, which can gain pathologic relevance in combination with proinflammatory cytokines under inflammatory conditions. On the other hand, intestinal barrier impairment can also result from transcellular antigen translocation via an initial endocytotic uptake into early endosomes, and this is intensified by proinflammatory cytokines as interferon-gamma and may thus play a relevant role in the onset of IBD. Taken together, barrier defects contribute to diarrhea by a leak flux mechanism (e.g., in IBD) and can cause mucosal inflammation by luminal antigen uptake. Immune regulation of epithelial functions by cytokines may cause barrier dysfunction not only by tight junction impairments but also by apoptotic leaks, transcytotic mechanisms, and mucosal gross lesions. PMID:19538319

  16. Coughing Wheezing Shortness of Breath Tightness in Chest

    MedlinePlus

    ... Issues Coughing Wheezing Shortness of Breath Tightness in Chest Past Issues / Fall 2006 Table of Contents For ... short of breath or feel tightness in your chest, you might have asthma. If you do, you ...

  17. Coughing Wheezing Shortness of Breath Tightness in Chest

    MedlinePlus

    ... Current Issue Past Issues Coughing Wheezing Shortness of Breath Tightness in Chest Past Issues / Fall 2006 Table ... you cough a lot, wheeze, are short of breath or feel tightness in your chest, you might ...

  18. Inward leakage in tight-fitting PAPRs.

    PubMed

    Koh, Frank C; Johnson, Arthur T; Rehak, Timothy E

    2011-01-01

    A combination of local flow measurement techniques and fog flow visualization was used to determine the inward leakage for two tight-fitting powered air-purifying respirators (PAPRs), the 3M Breathe-Easy PAPR and the SE 400 breathing demand PAPR. The PAPRs were mounted on a breathing machine head form, and flows were measured from the blower and into the breathing machine. Both respirators leaked a little at the beginning of inhalation, probably through their exhalation valves. In both cases, the leakage was not enough for fog to appear at the mouth of the head form. PMID:21647352

  19. Inward Leakage in Tight-Fitting PAPRs

    PubMed Central

    Koh, Frank C.; Johnson, Arthur T.; Rehak, Timothy E.

    2011-01-01

    A combination of local flow measurement techniques and fog flow visualization was used to determine the inward leakage for two tight-fitting powered air-purifying respirators (PAPRs), the 3M Breathe-Easy PAPR and the SE 400 breathing demand PAPR. The PAPRs were mounted on a breathing machine head form, and flows were measured from the blower and into the breathing machine. Both respirators leaked a little at the beginning of inhalation, probably through their exhalation valves. In both cases, the leakage was not enough for fog to appear at the mouth of the head form. PMID:21647352

  20. 18 CFR 270.304 - Tight formation gas.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false Tight formation gas... Requirements for Filings With Jurisdictional Agencies § 270.304 Tight formation gas. A person seeking a determination that natural gas is tight formation gas must file with the jurisdictional agency an...

  1. Leak-tight vertical membrane microvalves.

    PubMed

    Hansson, Jonas; Hillmering, Mikael; Haraldsson, Tommy; van der Wijngaart, Wouter

    2016-04-12

    Pneumatic microvalves are fundamental control components in a large range of microfluidic applications. Their key performance parameters are small size, i.e. occupying a minimum of microfluidic real estate, low flow resistance in the open state, and leak-tight closing at limited control pressures. In this work we present the successful design, realization and evaluation of the first leak-tight, vertical membrane, pneumatic microvalves. The realization of the vertical membrane microvalves is enabled by a novel dual-sided molding method for microstructuring monolithic 3D microfluidic networks in PDMS in a single step, eliminating the need for layer-to-layer alignment during bonding. We demonstrate minimum lateral device features down to 20-30 μm in size, and vertical via density of ∼30 000 per cm(2), which provides significant gains in chip real estate compared to previously reported PDMS manufacturing methods. In contrast to horizontal membrane microvalves, there are no manufacturing restrictions on the cross-sectional geometry of the flow channel of the vertical membrane microvalves. This allows tuning the design towards lower closing pressure or lower open state flow resistance compared to those of horizontal membrane microvalves. PMID:26983557

  2. Tight gas reservoirs: A visual depiction

    SciTech Connect

    Not Available

    1993-12-01

    Future gas supplies in the US will depend on an increasing contribution from unconventional sources such as overpressured and tight gas reservoirs. Exploitation of these resources and their conversion to economically producible gas reserves represents a major challenge. Meeting this challenge will require not only the continuing development and application of new technologies, but also a detailed understanding of the complex nature of the reservoirs themselves. This report seeks to promote understanding of these reservoirs by providing examples. Examples of gas productive overpressured tight reservoirs in the Greater Green River Basin, Wyoming are presented. These examples show log data (raw and interpreted), well completion and stimulation information, and production decline curves. A sampling of wells from the Lewis and Mesaverde formations are included. Both poor and good wells have been chosen to illustrate the range of productivity that is observed. The second section of this document displays decline curves and completion details for 30 of the best wells in the Greater Green River Basin. These are included to illustrate the potential that is present when wells are fortuitously located with respect to local stratigraphy and natural fracturing, and are successfully hydraulically fractured.

  3. Tricellular Tight Junctions in the Inner Ear

    PubMed Central

    2016-01-01

    Tight junctions (TJs) are structures that seal the space between the epithelial cell sheets. In the inner ear, the barrier function of TJs is indispensable for the separation of the endolymphatic and perilymphatic spaces, which is essential for the generation and maintenance of the endocochlear potential (EP). TJs are formed by the intercellular binding of membrane proteins, known as claudins, and mutations in these proteins cause deafness in humans and mice. Within the epithelial cell sheet, however, a bound structure is present at the site where the corners of three cells meet (tricellular tight junctions (tTJs)), and the maintenance of the barrier function at this location cannot be explained by the claudins alone. Tricellulin and the angulin family of proteins (angulin-1/LSR, angulin-2/ILDR1, and angulin-3/ILDR2) have been identified as tTJ-associated proteins. Tricellulin and ILDR1 are localized at the tTJ and alterations in these proteins have been reported to be involved in deafness. In this review, we will present the current state of knowledge for tTJs. PMID:27195292

  4. Tricellular Tight Junctions in the Inner Ear.

    PubMed

    Kitajiri, Shin-Ichiro; Katsuno, Tatsuya

    2016-01-01

    Tight junctions (TJs) are structures that seal the space between the epithelial cell sheets. In the inner ear, the barrier function of TJs is indispensable for the separation of the endolymphatic and perilymphatic spaces, which is essential for the generation and maintenance of the endocochlear potential (EP). TJs are formed by the intercellular binding of membrane proteins, known as claudins, and mutations in these proteins cause deafness in humans and mice. Within the epithelial cell sheet, however, a bound structure is present at the site where the corners of three cells meet (tricellular tight junctions (tTJs)), and the maintenance of the barrier function at this location cannot be explained by the claudins alone. Tricellulin and the angulin family of proteins (angulin-1/LSR, angulin-2/ILDR1, and angulin-3/ILDR2) have been identified as tTJ-associated proteins. Tricellulin and ILDR1 are localized at the tTJ and alterations in these proteins have been reported to be involved in deafness. In this review, we will present the current state of knowledge for tTJs. PMID:27195292

  5. Naturally fractured tight gas reservoir detection optimization

    SciTech Connect

    1998-11-30

    The work plan for October 1, 1997 to September 30, 1998 consisted of investigation of a number of topical areas. These topical areas were reported in four quarterly status reports, which were submitted to DOE earlier. These topical areas are reviewed in this volume. The topical areas covered during the year were: (1) Development of preliminary tests of a production method for determining areas of natural fracturing. Advanced Resources has demonstrated that such a relationship exists in the southern Piceance basin tight gas play. Natural fracture clusters are genetically related to stress concentrations (also called stress perturbations) associated with local deformation such a faulting. The mechanical explanation of this phenomenon is that deformation generally initiates at regions where the local stress field is elevated beyond the regional. (2) Regional structural and geologic analysis of the Greater Green River Basin (GGRB). Application of techniques developed and demonstrated during earlier phases of the project for sweet-spot delineation were demonstrated in a relatively new and underexplored play: tight gas from continuous-typeUpper Cretaceous reservoirs of the Greater Green River Basin (GGRB). The effort included data acquisition/processing, base map generation, geophysical and remote sensing analysis and the integration of these data and analyses. (3) Examination of the Table Rock field area in the northern Washakie Basin of the Greater Green River Basin. This effort was performed in support of Union Pacific Resources- and DOE-planned horizontal drilling efforts. The effort comprised acquisition of necessary seismic data and depth-conversion, mapping of major fault geometry, and analysis of displacement vectors, and the development of the natural fracture prediction. (4) Greater Green River Basin Partitioning. Building on fundamental fracture characterization work and prior work performed under this contract, namely structural analysis using satellite and

  6. Precision powder feeder

    DOEpatents

    Schlienger, M. Eric; Schmale, David T.; Oliver, Michael S.

    2001-07-10

    A new class of precision powder feeders is disclosed. These feeders provide a precision flow of a wide range of powdered materials, while remaining robust against jamming or damage. These feeders can be precisely controlled by feedback mechanisms.

  7. The Cost Implications of Less Tight Versus Tight Control of Hypertension in Pregnancy (CHIPS Trial)

    PubMed Central

    Ahmed, Rashid J.; Gafni, Amiram; Hu, Zheng Jing; Pullenayegum, Eleanor; von Dadelszen, Peter; Rey, Evelyne; Ross, Susan; Asztalos, Elizabeth; Murphy, Kellie E.; Menzies, Jennifer; Sanchez, J. Johanna; Ganzevoort, Wessel; Helewa, Michael; Lee, Shoo K.; Lee, Terry; Logan, Alexander G.; Moutquin, Jean-Marie; Singer, Joel; Thornton, Jim G.; Welch, Ross; Magee, Laura A.

    2016-01-01

    The CHIPS randomized controlled trial (Control of Hypertension in Pregnancy Study) found no difference in the primary perinatal or secondary maternal outcomes between planned “less tight” (target diastolic 100 mm Hg) and “tight” (target diastolic 85 mm Hg) blood pressure management strategies among women with chronic or gestational hypertension. This study examined which of these management strategies is more or less costly from a third-party payer perspective. A total of 981 women with singleton pregnancies and nonsevere, nonproteinuric chronic or gestational hypertension were randomized at 14 to 33 weeks to less tight or tight control. Resources used were collected from 94 centers in 15 countries and costed as if the trial took place in each of 3 Canadian provinces as a cost-sensitivity analysis. Eleven hospital ward and 24 health service costs were obtained from a similar trial and provincial government health insurance schedules of medical benefits. The mean total cost per woman–infant dyad was higher in less tight versus tight control, but the difference in mean total cost (DM) was not statistically significant in any province: Ontario ($30 191.62 versus $24 469.06; DM $5723, 95% confidence interval, −$296 to $12 272; P=0.0725); British Columbia ($30 593.69 versus $24 776.51; DM $5817; 95% confidence interval, −$385 to $12 349; P=0.0725); or Alberta ($31 510.72 versus $25 510.49; DM $6000.23; 95% confidence interval, −$154 to $12 781; P=0.0637). Tight control may benefit women without increasing risk to neonates (as shown in the main CHIPS trial), without additional (and possibly lower) cost to the healthcare system. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT01192412. PMID:27550914

  8. Air Tightness of US Homes: Model Development

    SciTech Connect

    Sherman, Max H.

    2006-05-01

    Air tightness is an important property of building envelopes. It is a key factor in determining infiltration and related wall-performance properties such as indoor air quality, maintainability and moisture balance. Air leakage in U.S. houses consumes roughly 1/3 of the HVAC energy but provides most of the ventilation used to control IAQ. The Lawrence Berkeley National Laboratory has been gathering residential air leakage data from many sources and now has a database of more than 100,000 raw measurements. This paper uses that database to develop a model for estimating air leakage as a function of climate, building age, floor area, building height, floor type, energy-efficiency and low-income designations. The model developed can be used to estimate the leakage distribution of populations of houses.

  9. Naturally fractured tight gas reservoir detection optimization

    SciTech Connect

    1999-06-01

    Building upon the partitioning of the Greater Green River Basin (GGRB) that was conducted last quarter, the goal of the work this quarter has been to conclude evaluation of the Stratos well and the prototypical Green River Deep partition, and perform the fill resource evaluation of the Upper Cretaceous tight gas play, with the goal of defining target areas of enhanced natural fracturing. The work plan for the quarter of November 1-December 31, 1998 comprised four tasks: (1) Evaluation of the Green River Deep partition and the Stratos well and examination of potential opportunity for expanding the use of E and P technology to low permeability, naturally fractured gas reservoirs, (2) Gas field studies, and (3) Resource analysis of the balance of the partitions.

  10. Recent resource assessments of tight gas reservoirs

    SciTech Connect

    Spencer, C.W.

    1984-04-01

    Two fairly recent estimates of natural gas recoverable from tight gas reservoirs in the US have been made. One was prepared in 1978, by Lewin and Associates for DOE (US Department of Energy) and the second was made by the NPC (National Petroleum Council) in 1980. Lewin estimated about 200 tcf is recoverable from the 14 most favorable regions in the US. The NPC estimated that about 500 tcf is recoverable from the entire onshore US. These studies involved a careful analysis of available data; however, both studies excluded large areas and great thicknesses of rock strata from their resource data base. The reasons for these exclusions were mostly lack of good well control and not absence of gas potential. Therefore, both assessments were conservative and the potential recoverable resource is probably much larger than even the 500 tcf estimated by the NPC. Unfortunately present-day technology is not able to consistently identify, stimulate, and produce large volumes of gas from lenticular and (or) deep tight reservoirs. The NPC recognized these problems and listed many research topics and programs, in their report, that should be undertaken to increase the amount of recoverable gas. A few of the more important informational needs are: (1) better methods to predict geometry of reservoirs, (2) improvement of log interpretation, (3) better prediction of natural fracture systems, (4) control of, and prediction of, hydraulic fracture height, length, and orientation, (5) elimination of formation damage, and (6) development of innovative reservoir stimulation methods. DOE has supported a number of research efforts directed toward solving many of these problems.

  11. Air tightness monitoring by IR thermography

    NASA Astrophysics Data System (ADS)

    Grinzato, Ermanno G.; Marinetti, Sergio; Bison, Paolo G.

    2004-04-01

    The standard air tightness test of containers is based on measurement of global parameters as the outlet of a specific gas, detected by specialised mass spectrometers. The identification and location of air leakages is extremely important especially for the container manufacturer. At the same time, the measure of the mass flux is of importance. IR Thermography has been successfully applied for leakages detection on buildings, but unfortunately, the noise due to The standard air tightness test of containers is based on measurement of global parameters as the outlet of a specific gas, detected by specialised mass spectrometers. The identification and location of air leakages is extremely important especially for the container manufacturer. At the same time, the measure of the mass flux is of importance. IR Thermography has been successfully applied for leakage detection on buildings, but unfortunately, the noise due to environment limits its applicability, particularly in case of a small flux. A new thermal procedure has been developed for the leakage detection. The technique is based on the stimulation of the envelope with a low oscillating heat flux and lock-in analysis. An airflow is injected, with a harmonically varying flowrate and a slightly higher temperature than the ambient. Then, the thermograms sequence is analyzed in the frequency domain. A review of quantitative techniques for the convective heat exchange measurement is reported. The procedure has been utilized for special containers used for both transport and exhibition of pictures inside museums. Tests performed before and after gaskets improvements show the capability of the technique to estimate qualitatively the airflow.

  12. Real-time kinematic surveying using tightly-coupled GPS and ultra-wideband ranging

    NASA Astrophysics Data System (ADS)

    Macgougan, Glenn D.

    Ultra-wideband (UWB) ranging radios, an emerging technology that offers precise, short distance, range measurements are investigated as a method to augment carrier-phase GPS positioning. This thesis begins with a discussion of radio-frequency based methods of augmenting high precision GPS and proposes to utilize UWB ranging technology in a tightly-coupled GPS and UWB position estimation filter. This thesis then provides an overview of UWB in the context of ranging applications and assesses the precision and accuracy of UWB ranging from both a theoretical perspective and a practical perspective using real data. Two types of commercially available UWB ranging radios are introduced which are used in testing. Actual ranging accuracy is assessed from line-of-sight testing in benign signal conditions and in outdoor testing with line-of-sight obstructions and strong reflection sources. A tightly-coupled GPS and UWB real-time kinematic (RTK) estimation method is developed and the performance of the system is evaluated in static and kinematic testing. The results of static testing show that the integrated solution provides better accuracy, better ability to resolve integer ambiguities and enhanced fixed ambiguity solution availability compared with GPS alone. The results of kinematic testing demonstrate that UWB errors can be successfully estimated in a real-time filter. In static and kinematic testing in a degraded GPS environment created by artificially inducing a 40° satellite elevation mask, subdecimetre accuracy was maintained. The tightly-coupled system is also tested to survey several external corner points of an eight story building. The tightly-coupled solution is compared to GPS-only, UWB-only, and loosely-coupled solutions. Sub-metre level solutions are maintained using tight-coupling in conditions where the solutions from the other three approaches are either unavailable or unreliable. The thesis also provides a novel and efficient method for deploying UWB

  13. Spatio-temporal modification of femtosecond focal spot under tight focusing condition.

    PubMed

    Jeong, Tae Moon; Weber, Stefan; Le Garrec, Bruno; Margarone, Daniele; Mocek, Tomas; Korn, Georg

    2015-05-01

    The focusing property of a focal spot of a femtosecond laser pulse is presented under tight focusing conditions (below f-number of 1). The spatial and temporal intensity distributions of a focused electric field are calculated by vector diffraction integrals and coherent superposition method. The validity of the calculation method is examined by comparing the intensity distribution obtained under a high f-number condition to that obtained with the fast Fourier transform method that assumes the scalar paraxial approximation. The spatial and temporal modifications under tight focusing conditions are described for a focused femtosecond laser pulse. The calculation results show that a peak intensity of about 2.5x10(24) W/cm2 can be achievable by tightly focusing a 12-fs, 10 PW laser pulse with a f/0.5 parabolic optic. The precise information on intensity distributions of a femtosecond focal spot obtained under a tight focusing condition will be crucial in assessing a focused intensity and in describing the motion of charged particles under an extremely strong electric field in ultra-relativistic and/or relativistic laser matter-interaction studies. PMID:25969256

  14. Tight Junction Properties Change During Epidermis Development

    PubMed Central

    Celli, A; Zhai, Y; Jiang, YJ; Crumrine, D; Elias, PM; Feingold, KR; Mauro, TM

    2012-01-01

    In terrestrial animals, the epidermal barrier transitions from covering an organism suspended in a liquid environment in utero, to protecting a terrestrial animal postnatally from air and environmental exposure. Tight junctions (TJ) are essential for establishing the epidermal permeability barrier during embryonic development, and modulate normal epidermal development and barrier functions postnatally. We now report that TJ function, as well as claudin-1 and occludin expression, change in parallel during late epidermal development. Specifically, TJ block the paracellular movement of Lanthanum (La3+) early in rat in vivo prenatal epidermal development, at gestational days 18–19, with concurrent upregulation of claudin-1 and occludin. TJ then become more permeable to ions and water as the fetus approaches parturition, concomitant with development of the lipid epidermal permeability barrier, at days 20–21. This sequence is recapitulated in cultured human epidermal equivalents (HEE), as assessed both by ultrastructural studies comparing permeation of large and small molecules, and by the standard electrophysiologic parameter of resistance (R), suggesting further that this pattern of development is intrinsic to mammalian epidermal development. These findings demonstrate that the role of TJ changes during epidermal development, and further suggest that the TJ-based and lipid-based epidermal permeability barriers are interdependent. PMID:22882565

  15. Functional analysis of tight junction organization.

    PubMed

    DiBona, D R

    1985-01-01

    The functional basis of tight junction design has been examined from the point of view that this rate-limiting barrier to paracellular transport is a multicompartment system. Review of the osmotic sensitivity of these structures points to the need for this sort of analysis for meaningful correlation of structure and function under a range of conditions. A similar conclusion is drawn with respect to results from voltage-clamping protocols where reversal of spontaneous transmural potential difference elicits parallel changes in both structure and function in much the same way as does reversal of naturally occurring osmotic gradients. In each case, it becomes necessary to regard the junction as a functionally polarized structure to account for observations of its rectifying properties. Lastly, the details of experimentally-induced junction deformation are examined in light of current theories of its organization; arguments are presented in favor of the view that the primary components of intramembranous organization (as viewed with freeze-fracture techniques) are lipidic rather than proteinaceous. PMID:4088839

  16. Enterocytes’ tight junctions: From molecules to diseases

    PubMed Central

    Assimakopoulos, Stelios F; Papageorgiou, Ismini; Charonis, Aristidis

    2011-01-01

    Tight junctions (TJs) are structures between cells where cells appear in the closest possible contact. They are responsible for sealing compartments when epithelial sheets are generated. They regulate the permeability of ions, (macro) molecules and cells via the paracellular pathway. Their structure at the electron microscopic level has been well known since the 1970s; however, only recently has their macromolecular composition been revealed. This review first examines the major macromolecular components of the TJs (occludin, claudins, junctional adhesion molecule and tricellulin) and then the associated macromolecules at the intracellular plaque [zonula occludens (ZO)-1, ZO-2, ZO-3, AF-6, cingulin, 7H6]. Emphasis is given to their interactions in order to begin to understand the mode of assembly of TJs. The functional significance of TJs is detailed and several mechanisms and factors involved are discussed briefly. Emphasis is given to the role of intestinal TJs and the alterations observed or speculated in diverse disease states. Specifically, intestinal TJs may exert a pathogenetic role in intestinal (inflammatory bowel disease, celiac disease) and extraintestinal diseases (diabetes type 1, food allergies, autoimmune diseases). Additionally, intestinal TJs may be secondarily disrupted during the course of diverse diseases, subsequently allowing the bacterial translocation phenomenon and promoting the systemic inflammatory response, which is often associated with clinical deterioration. The major questions in the field are highlighted. PMID:22184542

  17. Naturally fractured tight gas reservoir detection optimization

    SciTech Connect

    1999-04-30

    In March, work continued on characterizing probabilities for determining natural fracturing associated with the GGRB for the Upper Cretaceous tight gas plays. Structural complexity, based on potential field data and remote sensing data was completed. A resource estimate for the Frontier and Mesa Verde play was also completed. Further, work was also conducted to determine threshold economics for the play based on limited current production in the plays in the Wamsutter Ridge area. These analyses culminated in a presentation at FETC on 24 March 1999 where quantified natural fracture domains, mapped on a partition basis, which establish ''sweet spot'' probability for natural fracturing, were reviewed. That presentation is reproduced here as Appendix 1. The work plan for the quarter of January 1, 1999--March 31, 1999 comprised five tasks: (1) Evaluation of the GGRB partitions for structural complexity that can be associated with natural fractures, (2) Continued resource analysis of the balance of the partitions to determine areas with higher relative gas richness, (3) Gas field studies, (4) Threshold resource economics to determine which partitions would be the most prospective, and (5) Examination of the area around the Table Rock 4H well.

  18. 18 CFR 270.305 - Determination of tight formation areas.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... for tight formation designation, the stabilized production rate of natural gas, against atmospheric pressure, of wells completed for production in such portion of such formation, without stimulation, is...

  19. 18 CFR 270.305 - Determination of tight formation areas.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... for tight formation designation, the stabilized production rate of natural gas, against atmospheric pressure, of wells completed for production in such portion of such formation, without stimulation, is...

  20. US production of natural gas from tight reservoirs

    SciTech Connect

    Not Available

    1993-10-18

    For the purposes of this report, tight gas reservoirs are defined as those that meet the Federal Energy Regulatory Commission`s (FERC) definition of tight. They are generally characterized by an average reservoir rock permeability to gas of 0.1 millidarcy or less and, absent artificial stimulation of production, by production rates that do not exceed 5 barrels of oil per day and certain specified daily volumes of gas which increase with the depth of the reservoir. All of the statistics presented in this report pertain to wells that have been classified, from 1978 through 1991, as tight according to the FERC; i.e., they are ``legally tight`` reservoirs. Additional production from ``geologically tight`` reservoirs that have not been classified tight according to the FERC rules has been excluded. This category includes all producing wells drilled into legally designated tight gas reservoirs prior to 1978 and all producing wells drilled into physically tight gas reservoirs that have not been designated legally tight. Therefore, all gas production referenced herein is eligible for the Section 29 tax credit. Although the qualification period for the credit expired at the end of 1992, wells that were spudded (began to be drilled) between 1978 and May 1988, and from November 5, 1990, through year end 1992, are eligible for the tax credit for a subsequent period of 10 years. This report updates the EIA`s tight gas production information through 1991 and considers further the history and effect on tight gas production of the Federal Government`s regulatory and tax policy actions. It also provides some high points of the geologic background needed to understand the nature and location of low-permeability reservoirs.

  1. Claudins and the Modulation of Tight Junction Permeability

    PubMed Central

    Günzel, Dorothee

    2013-01-01

    Claudins are tight junction membrane proteins that are expressed in epithelia and endothelia and form paracellular barriers and pores that determine tight junction permeability. This review summarizes our current knowledge of this large protein family and discusses recent advances in our understanding of their structure and physiological functions. PMID:23589827

  2. Precise Countersinking Tool

    NASA Technical Reports Server (NTRS)

    Jenkins, Eric S.; Smith, William N.

    1992-01-01

    Tool countersinks holes precisely with only portable drill; does not require costly machine tool. Replaceable pilot stub aligns axis of tool with centerline of hole. Ensures precise cut even with imprecise drill. Designed for relatively low cutting speeds.

  3. Systematic Construction of Real Lapped Tight Frame Transforms

    PubMed Central

    Sandryhaila, Aliaksei; Chebira, Amina; Milo, Christina; Kovčcević, Jelena; Püschel, Markus

    2010-01-01

    We present a constructive algorithm for the design of real lapped equal-norm tight frame transforms. These transforms can be efficiently implemented through filter banks and have recently been proposed as a redundant counterpart to lapped orthogonal transforms, as well as an infinite-dimensional counterpart to harmonic tight frames. The proposed construction consists of two parts: First, we design a large class of new real lapped orthogonal transforms derived from submatrices of the discrete Fourier transform. Then, we seed these to obtain real lapped tight frame transforms corresponding to tight, equal-norm frames. We identify those frames that are maximally robust to erasures, and show that our construction leads to a large class of new lapped orthogonal transforms as well as new lapped tight frame transforms. PMID:20607116

  4. "Precision" drug development?

    PubMed

    Woodcock, J

    2016-02-01

    The concept of precision medicine has entered broad public consciousness, spurred by a string of targeted drug approvals, highlighted by the availability of personal gene sequences, and accompanied by some remarkable claims about the future of medicine. It is likely that precision medicines will require precision drug development programs. What might such programs look like? PMID:26331240

  5. Precision agricultural systems

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Precision agriculture is a new farming practice that has been developing since late 1980s. It has been variously referred to as precision farming, prescription farming, site-specific crop management, to name but a few. There are numerous definitions for precision agriculture, but the central concept...

  6. Precision measurements with an ultracold molecular clock

    NASA Astrophysics Data System (ADS)

    Zelevinsky, Tanya

    2014-05-01

    High-precision spectroscopy has been instrumental in the progress of atomic physics. In this talk, we extend precision spectroscopy techniques to ultracold diatomic strontium molecules tightly trapped in an optical lattice, and discuss the results from the point of view of molecular and fundamental science. For weakly bound molecules near the atomic threshold corresponding to the narrow intercombination transition, we observe peculiar and unexpected physics, including multiply forbidden transitions and anomalously large linear and quadratic Zeeman shifts. The Zeeman shifts are highly sensitive to nonadiabatic mixing angles of the molecular wave functions. For the first time, we quantitatively compare the electric- and magnetic-dipole transition strengths for forbidden transitions in molecules, and discuss the dependence on the internuclear separation. In addition, we study ground state molecules, and discuss the present status of the molecular lattice clock and the physics it is able to probe. Magic-wavelength spectroscopy is successfully demonstrated for a range of narrow molecular transitions.

  7. Precision performance lamp technology

    NASA Astrophysics Data System (ADS)

    Bell, Dean A.; Kiesa, James E.; Dean, Raymond A.

    1997-09-01

    A principal function of a lamp is to produce light output with designated spectra, intensity, and/or geometric radiation patterns. The function of a precision performance lamp is to go beyond these parameters and into the precision repeatability of performance. All lamps are not equal. There are a variety of incandescent lamps, from the vacuum incandescent indictor lamp to the precision lamp of a blood analyzer. In the past the definition of a precision lamp was described in terms of wattage, light center length (LCL), filament position, and/or spot alignment. This paper presents a new view of precision lamps through the discussion of a new segment of lamp design, which we term precision performance lamps. The definition of precision performance lamps will include (must include) the factors of a precision lamp. But what makes a precision lamp a precision performance lamp is the manner in which the design factors of amperage, mscp (mean spherical candlepower), efficacy (lumens/watt), life, not considered individually but rather considered collectively. There is a statistical bias in a precision performance lamp for each of these factors; taken individually and as a whole. When properly considered the results can be dramatic to the system design engineer, system production manage and the system end-user. It can be shown that for the lamp user, the use of precision performance lamps can translate to: (1) ease of system design, (2) simplification of electronics, (3) superior signal to noise ratios, (4) higher manufacturing yields, (5) lower system costs, (6) better product performance. The factors mentioned above are described along with their interdependent relationships. It is statistically shown how the benefits listed above are achievable. Examples are provided to illustrate how proper attention to precision performance lamp characteristics actually aid in system product design and manufacturing to build and market more, market acceptable product products in the

  8. Advanced irrigation engineering: Precision and Precise

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Irrigation advances in precision irrigation (PI) or site-specific irrigation (SSI) have been considerable in research; however commercialization lags. A primary necessity for it is variability in soil texture that affects soil water holding capacity and crop yield. Basically, SSI/PI uses variable ra...

  9. Advanced irrigation engineering: Precision and Precise

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Irrigation advances in precision irrigation (PI) or site specific irrigation (SSI) have been considerable in research; however commercialization lags. A primary necessity for PI/SSI is variability in soil texture that affects soil water holding capacity and crop yield. Basically, SSI/PI uses variabl...

  10. A new method of evaluating tight gas sands pore structure from nuclear magnetic resonance (NMR) logs

    NASA Astrophysics Data System (ADS)

    Xiao, Liang; Mao, Zhi-qiang; Xie, Xiu-hong

    2016-04-01

    Tight gas sands always display such characteristics of ultra-low porosity, permeability, high irreducible water, low resistivity contrast, complicated pore structure and strong heterogeneity, these make that the conventional methods are invalid. Many effective gas bearing formations are considered as dry zones or water saturated layers, and cannot be identified and exploited. To improve tight gas sands evaluation, the best method is quantitative characterizing rock pore structure. The mercury injection capillary pressure (MICP) curves are advantageous in predicting formation pore structure. However, the MICP experimental measurements are limited due to the environment and economy factors, this leads formation pore structure cannot be consecutively evaluated. Nuclear magnetic resonance (NMR) logs are considered to be promising in evaluating rock pore structure. Generally, to consecutively quantitatively evaluate tight gas sands pore structure, the best method is constructing pseudo Pc curves from NMR logs. In this paper, based on the analysis of lab experimental results for 20 core samples, which were drilled from tight gas sandstone reservoirs of Sichuan basin, and simultaneously applied for lab MICP and NMR measurements, the relationships of piecewise power function between nuclear magnetic resonance (NMR) transverse relaxation T2 time and pore-throat radius Rc are established. A novel method, which is used to transform NMR reverse cumulative curve as pseudo capillary pressure (Pc) curve is proposed, and the corresponding model is established based on formation classification. By using this model, formation pseudo Pc curves can be consecutively synthesized. The pore throat radius distribution, and pore structure evaluation parameters, such as the average pore throat radius (Rm), the threshold pressure (Pd), the maximum pore throat radius (Rmax) and so on, can also be precisely extracted. After this method is extended into field applications, several tight gas

  11. Heavy ion beam probe systems for tight aspect ratio tokamaks

    SciTech Connect

    Melnikov, A.V.; Zimeleva, L.G.; Krupnik, L.I.; Nedzelskij, I.S.; Trofimenko, Y.V.; Minaev, V.B.

    1997-01-01

    We discuss the specific features of the application of heavy ion beam probe (HIBP) systems to tight aspect ratio tokamaks. We present and compare the HIBP projects for the TUMAN-3, GLOBUS, and COMPASS, where the inner part of the plasma is not available for regular chord diagnostics, so the HIBP becomes very desirable. All existing tight aspect ratio facilities and projects have a low (less than 1.9 T) toroidal field that requires a comparatively low beam energy range. The natural elongation and triangularity in tight aspect ratio tokamaks require an accurate calculation of the three-dimensional magnetic field for probing optimization. In comparison with traditional tokamaks, the detector grids have a wider energy interval. In general, the trajectories and detector grids for tight aspect ratio tokamaks become similar to the stellarator ones. Traditional and new probing schemes are suggested and discussed. {copyright} {ital 1997 American Institute of Physics.}

  12. Western tight gas sands advanced logging workshop proceedings

    SciTech Connect

    Jennings, J B; Carroll, Jr, H B

    1982-04-01

    An advanced logging research program is one major aspect of the Western Tight Sands Program. Purpose of this workshop is to help BETC define critical logging needs for tight gas sands and to allow free interchange of ideas on all aspects of the current logging research program. Sixteen papers and abstracts are included together with discussions. Separate abstracts have been prepared for the 12 papers. (DLC)

  13. Tightness-looseness across the 50 united states.

    PubMed

    Harrington, Jesse R; Gelfand, Michele J

    2014-06-01

    This research demonstrates wide variation in tightness-looseness (the strength of punishment and degree of latitude/permissiveness) at the state level in the United States, as well as its association with a variety of ecological and historical factors, psychological characteristics, and state-level outcomes. Consistent with theory and past research, ecological and man-made threats--such as a higher incidence of natural disasters, greater disease prevalence, fewer natural resources, and greater degree of external threat--predicted increased tightness at the state level. Tightness is also associated with higher trait conscientiousness and lower trait openness, as well as a wide array of outcomes at the state level. Compared with loose states, tight states have higher levels of social stability, including lowered drug and alcohol use, lower rates of homelessness, and lower social disorganization. However, tight states also have higher incarceration rates, greater discrimination and inequality, lower creativity, and lower happiness relative to loose states. In all, tightness-looseness provides a parsimonious explanation of the wide variation we see across the 50 states of the United States of America. PMID:24843116

  14. Improving the precision matrix for precision cosmology

    NASA Astrophysics Data System (ADS)

    Paz, Dante J.; Sánchez, Ariel G.

    2015-12-01

    The estimation of cosmological constraints from observations of the large-scale structure of the Universe, such as the power spectrum or the correlation function, requires the knowledge of the inverse of the associated covariance matrix, namely the precision matrix, Ψ . In most analyses, Ψ is estimated from a limited set of mock catalogues. Depending on how many mocks are used, this estimation has an associated error which must be propagated into the final cosmological constraints. For future surveys such as Euclid and Dark Energy Spectroscopic Instrument, the control of this additional uncertainty requires a prohibitively large number of mock catalogues. In this work, we test a novel technique for the estimation of the precision matrix, the covariance tapering method, in the context of baryon acoustic oscillation measurements. Even though this technique was originally devised as a way to speed up maximum likelihood estimations, our results show that it also reduces the impact of noisy precision matrix estimates on the derived confidence intervals, without introducing biases on the target parameters. The application of this technique can help future surveys to reach their true constraining power using a significantly smaller number of mock catalogues.

  15. Precision Optics Curriculum.

    ERIC Educational Resources Information Center

    Reid, Robert L.; And Others

    This guide outlines the competency-based, two-year precision optics curriculum that the American Precision Optics Manufacturers Association has proposed to fill the void that it suggests will soon exist as many of the master opticians currently employed retire. The model, which closely resembles the old European apprenticeship model, calls for 300…

  16. Tight gas sands study breaks down drilling and completion costs

    SciTech Connect

    Brunsman, B. ); Saunders, B. )

    1994-06-06

    Given the high cost to drill and complete tight gas sand wells, advances in drilling and completion technology that result in even modest cost savings to the producer have the potential to generate tremendous savings for the natural gas industry. The Gas Research Institute sponsored a study to evaluate drilling and completion costs in selected tight gas sands. The objective of the study was to identify major expenditures associated with tight gas sand development and determine their relative significance. A substantial sample of well cost data was collected for the study. Individual well cost data were collected from nearly 300 wells in three major tight gas sand formations: the Cotton Valley sand in East Texas, the Frontier sand in Wyoming, and the Wilcox sand in South Texas. The data were collected and organized by cost category for each formation. After the information was input into a data base, a simple statistical analysis was performed. The statistical analysis identified data discrepancies that were then resolved, and it helped allow conclusions to be drawn regarding drilling and completion costs in these tight sand formations. Results are presented.

  17. Precision liquid level sensor

    DOEpatents

    Field, M.E.; Sullivan, W.H.

    A precision liquid level sensor utilizes a balanced bridge, each arm including an air dielectric line. Changes in liquid level along one air dielectric line imbalance the bridge and create a voltage which is directly measurable across the bridge.

  18. Precision digital control systems

    NASA Astrophysics Data System (ADS)

    Vyskub, V. G.; Rozov, B. S.; Savelev, V. I.

    This book is concerned with the characteristics of digital control systems of great accuracy. A classification of such systems is considered along with aspects of stabilization, programmable control applications, digital tracking systems and servomechanisms, and precision systems for the control of a scanning laser beam. Other topics explored are related to systems of proportional control, linear devices and methods for increasing precision, approaches for further decreasing the response time in the case of high-speed operation, possibilities for the implementation of a logical control law, and methods for the study of precision digital control systems. A description is presented of precision automatic control systems which make use of electronic computers, taking into account the existing possibilities for an employment of computers in automatic control systems, approaches and studies required for including a computer in such control systems, and an analysis of the structure of automatic control systems with computers. Attention is also given to functional blocks in the considered systems.

  19. Precision displacement reference system

    DOEpatents

    Bieg, Lothar F.; Dubois, Robert R.; Strother, Jerry D.

    2000-02-22

    A precision displacement reference system is described, which enables real time accountability over the applied displacement feedback system to precision machine tools, positioning mechanisms, motion devices, and related operations. As independent measurements of tool location is taken by a displacement feedback system, a rotating reference disk compares feedback counts with performed motion. These measurements are compared to characterize and analyze real time mechanical and control performance during operation.

  20. Altering wettability to recover more oil from tight formations

    DOE PAGESBeta

    Brady, Patrick V.; Bryan, Charles R.; Thyne, Geoffrey; Li, Huina

    2016-06-03

    We describe here a method for chemically modifying fracturing fluids and overflushes to chemically increase oil recovery from tight formations. Oil wetting of tight formations is usually controlled by adhesion to illite, kerogen, or both; adhesion to carbonate minerals may also play a role. Oil-illite adhesion is sensitive to salinity, dissolved divalent cation content, and pH. We measure oil-rock adhesion with middle Bakken formation oil and core to verify a surface complexation model of reservoir wettability. The agreement between the model and experiments suggests that wettability trends in tight formations can be quantitatively predicted and that fracturing fluid and overflushmore » compositions can be individually tailored to increase oil recovery.« less

  1. Claudin heterogeneity and control of lung tight junctions.

    PubMed

    Koval, Michael

    2013-01-01

    Lung epithelial cells interconnected by tight junctions provide a barrier to the free diffusion of solutes into airspaces. Transmembrane tight junction proteins known as claudins are essential for epithelial barrier function. Claudins are regulated through interactions with each other that are coordinated with other transmembrane tight junction proteins and cytosolic scaffold proteins. Of the 14 claudins expressed by the alveolar epithelium, claudin-3, claudin-4, and claudin-18 are the most prominent; each confers unique properties to alveolar barrier function. In particular, a protective role for claudin-4 in preventing lung injury has emerged. By contrast, lung diseases that affect claudin expression and impair barrier function, including alcoholic lung syndrome and sepsis, prime the lung for pulmonary edema. Thus, approaches to restore and/or augment lung claudin expression provide potential targets for promoting healthy barrier function. PMID:23072447

  2. Undersampled MR Image Reconstruction with Data-Driven Tight Frame

    PubMed Central

    Liu, Jianbo; Wang, Shanshan; Peng, Xi; Liang, Dong

    2015-01-01

    Undersampled magnetic resonance image reconstruction employing sparsity regularization has fascinated many researchers in recent years under the support of compressed sensing theory. Nevertheless, most existing sparsity-regularized reconstruction methods either lack adaptability to capture the structure information or suffer from high computational load. With the aim of further improving image reconstruction accuracy without introducing too much computation, this paper proposes a data-driven tight frame magnetic image reconstruction (DDTF-MRI) method. By taking advantage of the efficiency and effectiveness of data-driven tight frame, DDTF-MRI trains an adaptive tight frame to sparsify the to-be-reconstructed MR image. Furthermore, a two-level Bregman iteration algorithm has been developed to solve the proposed model. The proposed method has been compared to two state-of-the-art methods on four datasets and encouraging performances have been achieved by DDTF-MRI. PMID:26199641

  3. Definitive evidence for the existence of tight junctions in invertebrates.

    PubMed

    Lane, N J; Chandler, H J

    1980-09-01

    Extensive and unequivocal tight junctions are here reported between the lateral borders of the cellular layer that circumscribes the arachnid (spider) central nervous system. This account details the features of these structures, which form a beltlike reticulum that is more complex than the simple linear tight junctions hitherto found in invertebrate tissues and which bear many of the characteristics of vertebrate zonulae occludentes. We also provide evidence that these junctions form the basis of a permeability barrier to exogenous compounds. In thin sections, the tight junctions are identifiable as punctate points of membrane apposition; they are seen to exclude the stain and appear as election- lucent moniliform strands along the lines of membrane fusion in en face views of uranyl-calcium-treated tissues. In freeze-fracture replicas, the regions of close membrane apposition exhibit P-face (PF) ridges and complementary E-face (EF) furrows that are coincident across face transitions, although slightly offset with respect to one another. The free inward diffusion of both ionic and colloidal lanthanum is inhibited by these punctate tight junctions so that they appear to form the basis of a circumferential blood-brain barrier. These results support the contention that tight junctions exist in the tissues of the invertebrata in spite of earlier suggestions that (a) they are unique to vertebrates and (b) septate junctions are the equivalent invertebrate occluding structure. The component tight junctional 8- to 10-nm-particulate PF ridges are intimately intercalated with, but clearly distinct from, inverted gap junctions possessing the 13-nm EF particles typical of arthropods. Hence, no confusion can occur as to which particles belong to each of the two junctional types, as commonly happens with vertebrate tissues, especially in the analysis of developing junctions. Indeed, their coexistance in this way supports the idea, over which there has been some controversy, that

  4. Brain barriers: Crosstalk between complex tight junctions and adherens junctions

    PubMed Central

    Tietz, Silvia

    2015-01-01

    Unique intercellular junctional complexes between the central nervous system (CNS) microvascular endothelial cells and the choroid plexus epithelial cells form the endothelial blood–brain barrier (BBB) and the epithelial blood–cerebrospinal fluid barrier (BCSFB), respectively. These barriers inhibit paracellular diffusion, thereby protecting the CNS from fluctuations in the blood. Studies of brain barrier integrity during development, normal physiology, and disease have focused on BBB and BCSFB tight junctions but not the corresponding endothelial and epithelial adherens junctions. The crosstalk between adherens junctions and tight junctions in maintaining barrier integrity is an understudied area that may represent a promising target for influencing brain barrier function. PMID:26008742

  5. Invisibility in non-Hermitian tight-binding lattices

    SciTech Connect

    Longhi, Stefano

    2010-09-15

    Reflectionless defects in Hermitian tight-binding lattices, synthesized by the intertwining operator technique of supersymmetric quantum mechanics, are generally not invisible and time-of-flight measurements could reveal the existence of the defects. Here it is shown that, in a certain class of non-Hermitian tight-binding lattices with complex hopping amplitudes, defects in the lattice can appear fully invisible to an outside observer. The synthesized non-Hermitian lattices with invisible defects possess a real-valued energy spectrum; however, they lack parity-time (PT) symmetry, which does not play any role in the present work.

  6. Tight coupling expansion and fully inhomogeneous magnetic fields

    SciTech Connect

    Giovannini, Massimo

    2006-09-15

    The tight coupling expansion, appropriately generalized to include large-scale magnetic fields, allows the estimate of the brightness perturbations of CMB anisotropies for typical wavelengths that are larger than the Hubble radius after matter-radiation equality. After discussing the basic features of the predecoupling initial conditions in the presence of fully inhomogeneous magnetic fields, the tight coupling expansion is studied both analytically and numerically. From the requirement that the amplitudes and phases of Sakharov oscillations are (predominantly) adiabatic and from the inferred value of the plateau in the temperature autocorrelation, the effects of the magnetized contribution can be systematically investigated and constrained.

  7. Acceleration of electrons by a tightly focused intense laser beam.

    PubMed

    Li, Jian-Xing; Zang, Wei-Ping; Li, Ya-Dong; Tian, Jian-Guo

    2009-07-01

    The recent proposal to use Weinger transformation field (WTF) [Opt. Express 17, 4959-4969 (2009)] for describing tightly focused laser beams is investigated here in detail. In order to validate the accuracy of WTF, we derive the numerical field (NF) from the plane wave spectrum method. WTF is compared with NF and Lax series field (LSF). Results show that LSF is accurate close to the beam axis and divergent far from the beam axis, and WTF is always accurate. Moreover, electron dynamics in a tightly focused intense laser beam are simulated by LSF, WTF and NF, respectively. The results obtained by WTF are shown to be accurate. PMID:19582099

  8. Band structure of silicene in the tight binding approximation

    SciTech Connect

    Gert, A. V. Nestoklon, M. O.; Yassievich, I. N.

    2015-07-15

    The electronic structure of silicene is simulated by the tight binding method with the basis sp{sup 3}d{sup 5}s*. The results are in good agreement with ab initio calculations. The effective Hamiltonian of silicene in the vicinity of the Dirac point is constructed by the method of invariants. Silicon atoms in silicene are located in two parallel planes displaced perpendicularly to each other by Δ{sub z}; the energy spectrum essentially depends on this displacement. Using the tight binding technique, the coefficients of the effective Hamiltonian are determined for various values of Δ{sub z}.

  9. Real-time Kinematic Positioning of INS Tightly Aided Multi-GNSS Ionospheric Constrained PPP

    PubMed Central

    Gao, Zhouzheng; Shen, Wenbin; Zhang, Hongping; Niu, Xiaoji; Ge, Maorong

    2016-01-01

    Real-time Precise Point Positioning (PPP) technique is being widely applied for providing precise positioning services with the significant improvement on satellite precise products accuracy. With the rapid development of the multi-constellation Global Navigation Satellite Systems (multi-GNSS), currently, about 80 navigation satellites are operational in orbit. Obviously, PPP performance is dramatically improved with all satellites compared to that of GPS-only PPP. However, the performance of PPP could be evidently affected by unexpected and unavoidable severe observing environments, especially in the dynamic applications. Consequently, we apply Inertial Navigation System (INS) to the Ionospheric-Constrained (IC) PPP to overcome such drawbacks. The INS tightly aided multi-GNSS IC-PPP model can make full use of GNSS and INS observations to improve the PPP performance in terms of accuracy, availability, continuity, and convergence speed. Then, a set of airborne data is analyzed to evaluate and validate the improvement of multi-GNSS and INS on the performance of IC-PPP. PMID:27470270

  10. Real-time Kinematic Positioning of INS Tightly Aided Multi-GNSS Ionospheric Constrained PPP.

    PubMed

    Gao, Zhouzheng; Shen, Wenbin; Zhang, Hongping; Niu, Xiaoji; Ge, Maorong

    2016-01-01

    Real-time Precise Point Positioning (PPP) technique is being widely applied for providing precise positioning services with the significant improvement on satellite precise products accuracy. With the rapid development of the multi-constellation Global Navigation Satellite Systems (multi-GNSS), currently, about 80 navigation satellites are operational in orbit. Obviously, PPP performance is dramatically improved with all satellites compared to that of GPS-only PPP. However, the performance of PPP could be evidently affected by unexpected and unavoidable severe observing environments, especially in the dynamic applications. Consequently, we apply Inertial Navigation System (INS) to the Ionospheric-Constrained (IC) PPP to overcome such drawbacks. The INS tightly aided multi-GNSS IC-PPP model can make full use of GNSS and INS observations to improve the PPP performance in terms of accuracy, availability, continuity, and convergence speed. Then, a set of airborne data is analyzed to evaluate and validate the improvement of multi-GNSS and INS on the performance of IC-PPP. PMID:27470270

  11. Real-time Kinematic Positioning of INS Tightly Aided Multi-GNSS Ionospheric Constrained PPP

    NASA Astrophysics Data System (ADS)

    Gao, Zhouzheng; Shen, Wenbin; Zhang, Hongping; Niu, Xiaoji; Ge, Maorong

    2016-07-01

    Real-time Precise Point Positioning (PPP) technique is being widely applied for providing precise positioning services with the significant improvement on satellite precise products accuracy. With the rapid development of the multi-constellation Global Navigation Satellite Systems (multi-GNSS), currently, about 80 navigation satellites are operational in orbit. Obviously, PPP performance is dramatically improved with all satellites compared to that of GPS-only PPP. However, the performance of PPP could be evidently affected by unexpected and unavoidable severe observing environments, especially in the dynamic applications. Consequently, we apply Inertial Navigation System (INS) to the Ionospheric-Constrained (IC) PPP to overcome such drawbacks. The INS tightly aided multi-GNSS IC-PPP model can make full use of GNSS and INS observations to improve the PPP performance in terms of accuracy, availability, continuity, and convergence speed. Then, a set of airborne data is analyzed to evaluate and validate the improvement of multi-GNSS and INS on the performance of IC-PPP.

  12. Estimating sparse precision matrices

    NASA Astrophysics Data System (ADS)

    Padmanabhan, Nikhil; White, Martin; Zhou, Harrison H.; O'Connell, Ross

    2016-08-01

    We apply a method recently introduced to the statistical literature to directly estimate the precision matrix from an ensemble of samples drawn from a corresponding Gaussian distribution. Motivated by the observation that cosmological precision matrices are often approximately sparse, the method allows one to exploit this sparsity of the precision matrix to more quickly converge to an asymptotic 1/sqrt{N_sim} rate while simultaneously providing an error model for all of the terms. Such an estimate can be used as the starting point for further regularization efforts which can improve upon the 1/sqrt{N_sim} limit above, and incorporating such additional steps is straightforward within this framework. We demonstrate the technique with toy models and with an example motivated by large-scale structure two-point analysis, showing significant improvements in the rate of convergence. For the large-scale structure example, we find errors on the precision matrix which are factors of 5 smaller than for the sample precision matrix for thousands of simulations or, alternatively, convergence to the same error level with more than an order of magnitude fewer simulations.

  13. Precision Higgs Physics

    NASA Astrophysics Data System (ADS)

    Boughezal, Radja

    2015-04-01

    The future of the high energy physics program will increasingly rely upon precision studies looking for deviations from the Standard Model. Run I of the Large Hadron Collider (LHC) triumphantly discovered the long-awaited Higgs boson, and there is great hope in the particle physics community that this new state will open a portal onto a new theory of Nature at the smallest scales. A precision study of Higgs boson properties is needed in order to test whether this belief is true. New theoretical ideas and high-precision QCD tools are crucial to fulfill this goal. They become even more important as larger data sets from LHC Run II further reduce the experimental errors and theoretical uncertainties begin to dominate. In this talk, I will review recent progress in understanding Higgs properties,including the calculation of precision predictions needed to identify possible physics beyond the Standard Model in the Higgs sector. New ideas for measuring the Higgs couplings to light quarks as well as bounding the Higgs width in a model-independent way will be discussed. Precision predictions for Higgs production in association with jets and ongoing efforts to calculate the inclusive N3LO cross section will be reviewed.

  14. Estimating sparse precision matrices

    NASA Astrophysics Data System (ADS)

    Padmanabhan, Nikhil; White, Martin; Zhou, Harrison H.; O'Connell, Ross

    2016-05-01

    We apply a method recently introduced to the statistical literature to directly estimate the precision matrix from an ensemble of samples drawn from a corresponding Gaussian distribution. Motivated by the observation that cosmological precision matrices are often approximately sparse, the method allows one to exploit this sparsity of the precision matrix to more quickly converge to an asymptotic 1/√{N_sim} rate while simultaneously providing an error model for all of the terms. Such an estimate can be used as the starting point for further regularization efforts which can improve upon the 1/√{N_sim} limit above, and incorporating such additional steps is straightforward within this framework. We demonstrate the technique with toy models and with an example motivated by large-scale structure two-point analysis, showing significant improvements in the rate of convergence. For the large-scale structure example we find errors on the precision matrix which are factors of 5 smaller than for the sample precision matrix for thousands of simulations or, alternatively, convergence to the same error level with more than an order of magnitude fewer simulations.

  15. Estimating sparse precision matrices

    NASA Astrophysics Data System (ADS)

    Padmanabhan, Nikhil; White, Martin; Zhou, Harrison H.; O'Connell, Ross

    2016-08-01

    We apply a method recently introduced to the statistical literature to directly estimate the precision matrix from an ensemble of samples drawn from a corresponding Gaussian distribution. Motivated by the observation that cosmological precision matrices are often approximately sparse, the method allows one to exploit this sparsity of the precision matrix to more quickly converge to an asymptotic 1/√{N_sim} rate while simultaneously providing an error model for all of the terms. Such an estimate can be used as the starting point for further regularization efforts which can improve upon the 1/√{N_sim} limit above, and incorporating such additional steps is straightforward within this framework. We demonstrate the technique with toy models and with an example motivated by large-scale structure two-point analysis, showing significant improvements in the rate of convergence. For the large-scale structure example, we find errors on the precision matrix which are factors of 5 smaller than for the sample precision matrix for thousands of simulations or, alternatively, convergence to the same error level with more than an order of magnitude fewer simulations.

  16. How Physics Got Precise

    SciTech Connect

    Kleppner, Daniel

    2005-01-19

    Although the ancients knew the length of the year to about ten parts per million, it was not until the end of the 19th century that precision measurements came to play a defining role in physics. Eventually such measurements made it possible to replace human-made artifacts for the standards of length and time with natural standards. For a new generation of atomic clocks, time keeping could be so precise that the effects of the local gravitational potentials on the clock rates would be important. This would force us to re-introduce an artifact into the definition of the second - the location of the primary clock. I will describe some of the events in the history of precision measurements that have led us to this pleasing conundrum, and some of the unexpected uses of atomic clocks today.

  17. Precision gap particle separator

    DOEpatents

    Benett, William J.; Miles, Robin; Jones, II., Leslie M.; Stockton, Cheryl

    2004-06-08

    A system for separating particles entrained in a fluid includes a base with a first channel and a second channel. A precision gap connects the first channel and the second channel. The precision gap is of a size that allows small particles to pass from the first channel into the second channel and prevents large particles from the first channel into the second channel. A cover is positioned over the base unit, the first channel, the precision gap, and the second channel. An port directs the fluid containing the entrained particles into the first channel. An output port directs the large particles out of the first channel. A port connected to the second channel directs the small particles out of the second channel.

  18. Precision Muonium Spectroscopy

    NASA Astrophysics Data System (ADS)

    Jungmann, Klaus P.

    2016-09-01

    The muonium atom is the purely leptonic bound state of a positive muon and an electron. It has a lifetime of 2.2 µs. The absence of any known internal structure provides for precision experiments to test fundamental physics theories and to determine accurate values of fundamental constants. In particular ground state hyperfine structure transitions can be measured by microwave spectroscopy to deliver the muon magnetic moment. The frequency of the 1s-2s transition in the hydrogen-like atom can be determined with laser spectroscopy to obtain the muon mass. With such measurements fundamental physical interactions, in particular quantum electrodynamics, can also be tested at highest precision. The results are important input parameters for experiments on the muon magnetic anomaly. The simplicity of the atom enables further precise experiments, such as a search for muonium-antimuonium conversion for testing charged lepton number conservation and searches for possible antigravity of muons and dark matter.

  19. Tightness of stability bounds by null space property

    NASA Astrophysics Data System (ADS)

    Chen, Xuemei; Wang, Rongrong

    2015-08-01

    The null space property (NSP) and the restricted isometry property (RIP) are two properties which have received considerable attention in the compressed sensing literature. It is known that the null space property guarantees a less than ideal stability result. In this paper, we show that this bound is actually tight by specific construction, which implies a fundamental difference between NSP and RIP.

  20. 18 CFR 270.304 - Tight formation gas.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Tight formation gas. 270.304 Section 270.304 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY PROCEDURES GOVERNING DETERMINATIONS FOR TAX CREDIT PURPOSES DETERMINATION PROCEDURES Requirements for Filings...

  1. 18 CFR 270.304 - Tight formation gas.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Tight formation gas. 270.304 Section 270.304 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY PROCEDURES GOVERNING DETERMINATIONS FOR TAX CREDIT PURPOSES DETERMINATION PROCEDURES Requirements for Filings...

  2. 18 CFR 270.305 - Determination of tight formation areas.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Determination of tight formation areas. 270.305 Section 270.305 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY PROCEDURES GOVERNING DETERMINATIONS FOR TAX CREDIT PURPOSES DETERMINATION PROCEDURES Requirements...

  3. Tight Junction Pore and Leak Pathways: A Dynamic Duo

    PubMed Central

    Raleigh, David R.; Yu, Dan; Turner, Jerrold R.

    2015-01-01

    Tissue barriers that restrict passage of liquids, ions, and larger solutes are essential for the development of multicellular organisms. In simple organisms this allows distinct cell types to interface with the external environment. In more complex species, the diversity of cell types capable of forming barriers increases dramatically. Although the plasma membranes of these barrier-forming cells prevent flux of most hydrophilic solutes, the paracellular, or shunt, pathway between cells must also be sealed. This function is accomplished in vertebrates by the zonula occludens, or tight junction. The tight junction barrier is not absolute but is selectively permeable and is able to discriminate between solutes on the basis of size and charge. Many tight junction components have been identified over the past 20 years, and recent progress has provided new insights into the proteins and interactions that regulate structure and function. This review presents these data in a historical context and proposes an integrated model in which dynamic regulation of tight junction protein interactions determines barrier function. PMID:20936941

  4. Estrogen Modulates Expression of Tight Junction Proteins in Rat Vagina

    PubMed Central

    Oh, Kyung-Jin; Ahn, Kyuyoun

    2016-01-01

    Background. The objectives of this study were to investigate the localization of tight junctions and the modulation of zonula occludens- (ZO-) 1, occludin and claudin-1 expression by estrogen in castrated female rat vagina. Female Sprague-Dawley rats (230–240 g, n = 45) were divided into three groups and subjected to a sham operation (control group, n = 15), bilateral ovariectomy (Ovx group, n = 15), or bilateral ovariectomy followed by daily subcutaneous injection of 17β-estradiol (50 μg/kg/day, Ovx + Est group, n = 15). The cellular localization and expression of ZO-1, occludin, and claudin-1 were determined in each group by immunohistochemistry and western blot. Results. Expression of ZO-1 was diffuse in all groups, with the highest intensity in the superficial epithelium in the control group. Occludin was localized in the intermediate and basal epithelium. Claudin-1 was most intense in the superficial layer of the vaginal epithelium in the control group. Expression of ZO-1, occludin, and claudin-1 was significantly decreased after ovariectomy and was restored to the level of the control after estrogen replacement. Conclusions. Tight junctions are distinctly localized in rat vagina, and estrogen modulates the expression of tight junctions. Further researches are needed to clarify the functional role of tight junctions in vaginal lubrication. PMID:27127786

  5. Superfast computations of dual and tight Gabor atoms

    NASA Astrophysics Data System (ADS)

    Qiu, Sigang

    1995-09-01

    We consider a class of Gabor-type matrices and develop simplified Gabor-type matrix operations. As applications to discrete Gabor transforms, we propose `superfast' algorithms for determining the inverse of Gabor frame operators and the square roots of the Gabor frame operators as well as the dual Gabor and tight Gabor atoms. Besides, we summarize briefly some additional results.

  6. Aspirator modification for the removal of mosquitoes from tight spaces

    Technology Transfer Automated Retrieval System (TEKTRAN)

    An insect aspirator was modified to remove mosquitoes that entered an animal-baited experimental cage-within-a-cage. The modified aspirator is easy to maneuver inside tight spaces, powerful enough to aspirate mosquitoes but not remove scales or fluorescent marking powders, and will run continuously...

  7. Si Tight-Binding Parameters from Genetic Algorithm Fitting

    NASA Technical Reports Server (NTRS)

    Klimeck, G.; Bowen, R.; Boykin, T.; Salazar-Lazaro, C.; Cwik, T.; Stoica, A.

    1999-01-01

    Quantum mechanical simulations of carrier transport in Si require an accurate model of the complicated Si bandstructure. Tight-binding models are an attractive method of choice since they bear the full electronic structure symmetry in them and they can discretize a realistic device on an atomic scale.

  8. Method of making pressure tight seal for super alloy

    NASA Technical Reports Server (NTRS)

    Little, R. E. (Inventor)

    1973-01-01

    A procedure for forming a pressure tight seal along two edges of super alloy sheets is presented. The procedure consists of flame spraying a powdered aluminum-nickel composition on the joint. The use of frozen carbon dioxide and carbon dioxide gas to maintain a low temperature environment during the flame spraying is described.

  9. Predictor variables for forward scapular posture including posterior shoulder tightness.

    PubMed

    Lee, Ji-Hyun; Cynn, Heon-seock; Yi, Chung-Hwi; Kwon, Oh-yun; Yoon, Tae-Lim

    2015-04-01

    The purpose of this study was (1) to determine the relationships between the degree of forward scapular posture and the pectoralis minor index, the strength of the serratus anterior, the thoracic spine angle, and posterior shoulder tightness, and (2) to identify predictors of forward scapular posture, including posterior shoulder tightness. The study recruited eighteen subjects with forward scapular posture and objectively measured the acromion distance, the pectoralis minor index, and the strength of the serratus anterior muscle of each participant. The amount of glenohumeral horizontal adduction and internal rotation were evaluated to measure posterior shoulder tightness. There were high intra-rater reliabilities in all measurements. The measurement results showed a statistically strong negative correlation between the degree of forward scapular posture and the pectoralis minor index. They also revealed a moderate positive correlation between the degree of forward scapular posture and the thoracic spine angle and a moderate negative relationship between the degree of forward scapular posture and the amount of the glenohumeral horizontal adduction. A multiple regression analysis indicated that a total multiple regression model explained 93% of the amount of forward scapular posture. All predictor variables, including posterior shoulder tightness, should be considered while assessing, managing, and preventing forward scapular posture. PMID:25892380

  10. Precision Nova operations

    NASA Astrophysics Data System (ADS)

    Ehrlich, Robert B.; Miller, John L.; Saunders, Rodney L.; Thompson, Calvin E.; Weiland, Timothy L.; Laumann, Curt W.

    1995-12-01

    To improve the symmetry of x-ray drive on indirectly driven ICF capsules, we have increased the accuracy of operating procedures and diagnostics on the Nova laser. Precision Nova operations include routine precision power balance to within 10% rms in the 'foot' and 5% rms in the peak of shaped pulses, beam synchronization to within 10 ps rms, and pointing of the beams onto targets to within 35 micrometer rms. We have also added a 'fail-safe chirp' system to avoid stimulated Brillouin scattering (SBS) in optical components during high energy shots.

  11. Precision Nova operations

    SciTech Connect

    Ehrlich, R.B.; Miller, J.L.; Saunders, R.L.; Thompson, C.E.; Weiland, T.L.; Laumann, C.W.

    1995-09-01

    To improve the symmetry of x-ray drive on indirectly driven ICF capsules, we have increased the accuracy of operating procedures and diagnostics on the Nova laser. Precision Nova operations includes routine precision power balance to within 10% rms in the ``foot`` and 5% nns in the peak of shaped pulses, beam synchronization to within 10 ps rms, and pointing of the beams onto targets to within 35 {mu}m rms. We have also added a ``fail-safe chirp`` system to avoid Stimulated Brillouin Scattering (SBS) in optical components during high energy shots.

  12. Precision electron polarimetry

    SciTech Connect

    Chudakov, Eugene A.

    2013-11-01

    A new generation of precise Parity-Violating experiments will require a sub-percent accuracy of electron beam polarimetry. Compton polarimetry can provide such accuracy at high energies, but at a few hundred MeV the small analyzing power limits the sensitivity. M{\\o}ller polarimetry provides a high analyzing power independent on the beam energy, but is limited by the properties of the polarized targets commonly used. Options for precision polarimetry at ~300 MeV will be discussed, in particular a proposal to use ultra-cold atomic hydrogen traps to provide a 100\\%-polarized electron target for M{\\o}ller polarimetry.

  13. Precision electron polarimetry

    SciTech Connect

    Chudakov, E.

    2013-11-07

    A new generation of precise Parity-Violating experiments will require a sub-percent accuracy of electron beam polarimetry. Compton polarimetry can provide such accuracy at high energies, but at a few hundred MeV the small analyzing power limits the sensitivity. Mo/ller polarimetry provides a high analyzing power independent on the beam energy, but is limited by the properties of the polarized targets commonly used. Options for precision polarimetry at 300 MeV will be discussed, in particular a proposal to use ultra-cold atomic hydrogen traps to provide a 100%-polarized electron target for Mo/ller polarimetry.

  14. Precision Heating Process

    NASA Technical Reports Server (NTRS)

    1992-01-01

    A heat sealing process was developed by SEBRA based on technology that originated in work with NASA's Jet Propulsion Laboratory. The project involved connecting and transferring blood and fluids between sterile plastic containers while maintaining a closed system. SEBRA markets the PIRF Process to manufacturers of medical catheters. It is a precisely controlled method of heating thermoplastic materials in a mold to form or weld catheters and other products. The process offers advantages in fast, precise welding or shape forming of catheters as well as applications in a variety of other industries.

  15. Precision manometer gauge

    DOEpatents

    McPherson, M.J.; Bellman, R.A.

    1982-09-27

    A precision manometer gauge which locates a zero height and a measured height of liquid using an open tube in communication with a reservoir adapted to receive the pressure to be measured. The open tube has a reference section carried on a positioning plate which is moved vertically with machine tool precision. Double scales are provided to read the height of the positioning plate accurately, the reference section being inclined for accurate meniscus adjustment, and means being provided to accurately locate a zero or reference position.

  16. Precision manometer gauge

    DOEpatents

    McPherson, Malcolm J.; Bellman, Robert A.

    1984-01-01

    A precision manometer gauge which locates a zero height and a measured height of liquid using an open tube in communication with a reservoir adapted to receive the pressure to be measured. The open tube has a reference section carried on a positioning plate which is moved vertically with machine tool precision. Double scales are provided to read the height of the positioning plate accurately, the reference section being inclined for accurate meniscus adjustment, and means being provided to accurately locate a zero or reference position.

  17. MICROLENSING DISCOVERY OF A POPULATION OF VERY TIGHT, VERY LOW MASS BINARY BROWN DWARFS

    SciTech Connect

    Choi, J.-Y.; Han, C.; Udalski, A.; Sumi, T.; Gaudi, B. S.; Gould, A.; Bennett, D. P.; Dominik, M.; Beaulieu, J.-P.; Tsapras, Y.; Bozza, V.; Abe, F.; Furusawa, K.; Itow, Y.; Bond, I. A.; Ling, C. H.; Botzler, C. S.; Freeman, M.; Chote, P.; Fukui, A.; Collaboration: MOA Collaboration; OGLE Collaboration; muFUN Collaboration; MiNDSTEp Consortium; PLANET Collaboration; RoboNet Collaboration; and others

    2013-05-10

    Although many models have been proposed, the physical mechanisms responsible for the formation of low-mass brown dwarfs (BDs) are poorly understood. The multiplicity properties and minimum mass of the BD mass function provide critical empirical diagnostics of these mechanisms. We present the discovery via gravitational microlensing of two very low mass, very tight binary systems. These binaries have directly and precisely measured total system masses of 0.025 M{sub Sun} and 0.034 M{sub Sun }, and projected separations of 0.31 AU and 0.19 AU, making them the lowest-mass and tightest field BD binaries known. The discovery of a population of such binaries indicates that BD binaries can robustly form at least down to masses of {approx}0.02 M{sub Sun }. Future microlensing surveys will measure a mass-selected sample of BD binary systems, which can then be directly compared to similar samples of stellar binaries.

  18. Precision bolometer bridge

    NASA Technical Reports Server (NTRS)

    White, D. R.

    1968-01-01

    Prototype precision bolometer calibration bridge is manually balanced device for indicating dc bias and balance with either dc or ac power. An external galvanometer is used with the bridge for null indication, and the circuitry monitors voltage and current simultaneously without adapters in testing 100 and 200 ohm thin film bolometers.

  19. Precision metal molding

    NASA Technical Reports Server (NTRS)

    Townhill, A.

    1967-01-01

    Method provides precise alignment for metal-forming dies while permitting minimal thermal expansion without die warpage or cavity space restriction. The interfacing dowel bars and die side facings are arranged so the dies are restrained in one orthogonal angle and permitted to thermally expand in the opposite orthogonal angle.

  20. Precision liquid level sensor

    DOEpatents

    Field, M.E.; Sullivan, W.H.

    1985-01-29

    A precision liquid level sensor utilizes a balanced R. F. bridge, each arm including an air dielectric line. Changes in liquid level along one air dielectric line imbalance the bridge and create a voltage which is directly measurable across the bridge. 2 figs.

  1. Precision liquid level sensor

    DOEpatents

    Field, Michael E.; Sullivan, William H.

    1985-01-01

    A precision liquid level sensor utilizes a balanced R. F. bridge, each arm including an air dielectric line. Changes in liquid level along one air dielectric line imbalance the bridge and create a voltage which is directly measurable across the bridge.

  2. Precision in Stereochemical Terminology

    ERIC Educational Resources Information Center

    Wade, Leroy G., Jr.

    2006-01-01

    An analysis of relatively new terminology that has given multiple definitions often resulting in students learning principles that are actually false is presented with an example of the new term stereogenic atom introduced by Mislow and Siegel. The Mislow terminology would be useful in some cases if it were used precisely and correctly, but it is…

  3. Precision physics at LHC

    SciTech Connect

    Hinchliffe, I.

    1997-05-01

    In this talk the author gives a brief survey of some physics topics that will be addressed by the Large Hadron Collider currently under construction at CERN. Instead of discussing the reach of this machine for new physics, the author gives examples of the types of precision measurements that might be made if new physics is discovered.

  4. Advanced Hydraulic Fracturing Technology for Unconventional Tight Gas Reservoirs

    SciTech Connect

    Stephen Holditch; A. Daniel Hill; D. Zhu

    2007-06-19

    The objectives of this project are to develop and test new techniques for creating extensive, conductive hydraulic fractures in unconventional tight gas reservoirs by statistically assessing the productivity achieved in hundreds of field treatments with a variety of current fracturing practices ranging from 'water fracs' to conventional gel fracture treatments; by laboratory measurements of the conductivity created with high rate proppant fracturing using an entirely new conductivity test - the 'dynamic fracture conductivity test'; and by developing design models to implement the optimal fracture treatments determined from the field assessment and the laboratory measurements. One of the tasks of this project is to create an 'advisor' or expert system for completion, production and stimulation of tight gas reservoirs. A central part of this study is an extensive survey of the productivity of hundreds of tight gas wells that have been hydraulically fractured. We have been doing an extensive literature search of the SPE eLibrary, DOE, Gas Technology Institute (GTI), Bureau of Economic Geology and IHS Energy, for publicly available technical reports about procedures of drilling, completion and production of the tight gas wells. We have downloaded numerous papers and read and summarized the information to build a database that will contain field treatment data, organized by geographic location, and hydraulic fracture treatment design data, organized by the treatment type. We have conducted experimental study on 'dynamic fracture conductivity' created when proppant slurries are pumped into hydraulic fractures in tight gas sands. Unlike conventional fracture conductivity tests in which proppant is loaded into the fracture artificially; we pump proppant/frac fluid slurries into a fracture cell, dynamically placing the proppant just as it occurs in the field. From such tests, we expect to gain new insights into some of the critical issues in tight gas fracturing, in

  5. High-precision camera distortion measurements with a ``calibration harp''

    NASA Astrophysics Data System (ADS)

    Tang, Zhongwei; Grompone von Gioi, Rafael; Monasse, Pascal; Morel, Jean-Michel

    2012-10-01

    This paper addresses the high precision measurement of the distortion of a digital camera from photographs. Traditionally, this distortion is measured from photographs of a flat pattern which contains aligned elements. Nevertheless, it is nearly impossible to fabricate a very flat pattern and to validate its flatness. This fact limits the attainable measurable precisions. In contrast, it is much easier to obtain physically very precise straight lines by tightly stretching good quality strings on a frame. Taking literally "plumb-line methods", we built a "calibration harp" instead of the classic flat patterns to obtain a high precision measurement tool, demonstrably reaching 2/100 pixel precisions. The harp is complemented with the algorithms computing automatically from harp photographs two different and complementary lens distortion measurements. The precision of the method is evaluated on images corrected by state-of-the-art distortion correction algorithms, and by popular software. Three applications are shown: first an objective and reliable measurement of the result of any distortion correction. Second, the harp permits to control state-of-the art global camera calibration algorithms: It permits to select the right distortion model, thus avoiding internal compensation errors inherent to these methods. Third, the method replaces manual procedures in other distortion correction methods, makes them fully automatic, and increases their reliability and precision.

  6. Differences between tight and loose cultures: a 33-nation study.

    PubMed

    Gelfand, Michele J; Raver, Jana L; Nishii, Lisa; Leslie, Lisa M; Lun, Janetta; Lim, Beng Chong; Duan, Lili; Almaliach, Assaf; Ang, Soon; Arnadottir, Jakobina; Aycan, Zeynep; Boehnke, Klaus; Boski, Pawel; Cabecinhas, Rosa; Chan, Darius; Chhokar, Jagdeep; D'Amato, Alessia; Ferrer, Montse; Fischlmayr, Iris C; Fischer, Ronald; Fülöp, Marta; Georgas, James; Kashima, Emiko S; Kashima, Yoshishima; Kim, Kibum; Lempereur, Alain; Marquez, Patricia; Othman, Rozhan; Overlaet, Bert; Panagiotopoulou, Penny; Peltzer, Karl; Perez-Florizno, Lorena R; Ponomarenko, Larisa; Realo, Anu; Schei, Vidar; Schmitt, Manfred; Smith, Peter B; Soomro, Nazar; Szabo, Erna; Taveesin, Nalinee; Toyama, Midori; Van de Vliert, Evert; Vohra, Naharika; Ward, Colleen; Yamaguchi, Susumu

    2011-05-27

    With data from 33 nations, we illustrate the differences between cultures that are tight (have many strong norms and a low tolerance of deviant behavior) versus loose (have weak social norms and a high tolerance of deviant behavior). Tightness-looseness is part of a complex, loosely integrated multilevel system that comprises distal ecological and historical threats (e.g., high population density, resource scarcity, a history of territorial conflict, and disease and environmental threats), broad versus narrow socialization in societal institutions (e.g., autocracy, media regulations), the strength of everyday recurring situations, and micro-level psychological affordances (e.g., prevention self-guides, high regulatory strength, need for structure). This research advances knowledge that can foster cross-cultural understanding in a world of increasing global interdependence and has implications for modeling cultural change. PMID:21617077

  7. Air quality in tightly sealed and passive homes

    SciTech Connect

    Scott, L.A.

    1981-09-01

    Indoor air quality has attracted increasing attention during the past few yars. Pollutants generated from combustion, building materials, and human activities may reach significant levels in the indoor environment to produce adverse health effects. This report deals with the classes of pollutants and their sources, and the significance of reported levels, possible health effects, and control strategies in relation to tightly sealed and passive solar construction techniques. In tightly sealed homes, residential air-to-air heat exchangers, whose design and performance are discussed, offer one method of improving air quality at reasonable cost. It is recommended that further research be implemented to identify hazardous concentrations of pollutants and set standards to minimize health impacts in the search for new energy innovations.

  8. Enteropathogenic E. coli: breaking the intestinal tight junction barrier

    PubMed Central

    Singh, Anand Prakash; Aijaz, Saima

    2016-01-01

    Enteropathogenic E. coli (EPEC) causes acute intestinal infections in infants in the developing world. Infection typically spreads through contaminated food and water and leads to severe, watery diarrhea. EPEC attaches to the intestinal epithelial cells and directly injects virulence factors which modulate multiple signaling pathways leading to host cell dysfunction. However, the molecular mechanisms that regulate the onset of diarrhea are poorly defined. A major target of EPEC is the host cell tight junction complex which acts as a barrier and regulates the passage of water and solutes through the paracellular space. In this review, we focus on the EPEC effectors that target the epithelial barrier, alter its functions and contribute to leakage through the tight junctions. PMID:27239268

  9. A tightly inducible riboswitch system in Synechocystis sp. PCC 6803.

    PubMed

    Ohbayashi, Ryudo; Akai, Hideto; Yoshikawa, Hirofumi; Hess, Wolfgang R; Watanabe, Satoru

    2016-07-14

    Cyanobacteria are photosynthetic microorganisms that serve as experimental model organisms for the study of photosynthesis, environmental stress responses, and the production of biofuels. Genetic tools for bioengineering have been developed as a result of such studies. However, there is still room for improvement for the tight control of experimental protein expression in these microorganisms. Here, we describe an expression system controlled by a theophylline-responsive riboswitch that we have constructed in the cyanobacterium Synechocystis sp. PCC 6803. We demonstrate that, in response to different theophylline concentrations, this riboswitch can tightly control green fluorescence protein expression in Synechocystis. Thus, this system is useful as a tool for genetic engineering and the synthetic biology of cyanobacteria. PMID:27250662

  10. Precision synchrotron radiation detectors

    SciTech Connect

    Levi, M.; Rouse, F.; Butler, J.; Jung, C.K.; Lateur, M.; Nash, J.; Tinsman, J.; Wormser, G.; Gomez, J.J.; Kent, J.

    1989-03-01

    Precision detectors to measure synchrotron radiation beam positions have been designed and installed as part of beam energy spectrometers at the Stanford Linear Collider (SLC). The distance between pairs of synchrotron radiation beams is measured absolutely to better than 28 /mu/m on a pulse-to-pulse basis. This contributes less than 5 MeV to the error in the measurement of SLC beam energies (approximately 50 GeV). A system of high-resolution video cameras viewing precisely-aligned fiducial wire arrays overlaying phosphorescent screens has achieved this accuracy. Also, detectors of synchrotron radiation using the charge developed by the ejection of Compton-recoil electrons from an array of fine wires are being developed. 4 refs., 5 figs., 1 tab.

  11. A passion for precision

    SciTech Connect

    2010-05-19

    For more than three decades, the quest for ever higher precision in laser spectroscopy of the simple hydrogen atom has inspired many advances in laser, optical, and spectroscopic techniques, culminating in femtosecond laser optical frequency combs  as perhaps the most precise measuring tools known to man. Applications range from optical atomic clocks and tests of QED and relativity to searches for time variations of fundamental constants. Recent experiments are extending frequency comb techniques into the extreme ultraviolet. Laser frequency combs can also control the electric field of ultrashort light pulses, creating powerful new tools for the emerging field of attosecond science.Organiser(s): L. Alvarez-Gaume / PH-THNote: * Tea & coffee will be served at 16:00.

  12. Towards precision medicine.

    PubMed

    Ashley, Euan A

    2016-08-16

    There is great potential for genome sequencing to enhance patient care through improved diagnostic sensitivity and more precise therapeutic targeting. To maximize this potential, genomics strategies that have been developed for genetic discovery - including DNA-sequencing technologies and analysis algorithms - need to be adapted to fit clinical needs. This will require the optimization of alignment algorithms, attention to quality-coverage metrics, tailored solutions for paralogous or low-complexity areas of the genome, and the adoption of consensus standards for variant calling and interpretation. Global sharing of this more accurate genotypic and phenotypic data will accelerate the determination of causality for novel genes or variants. Thus, a deeper understanding of disease will be realized that will allow its targeting with much greater therapeutic precision. PMID:27528417

  13. Precision Polarization of Neutrons

    NASA Astrophysics Data System (ADS)

    Martin, Elise; Barron-Palos, Libertad; Couture, Aaron; Crawford, Christopher; Chupp, Tim; Danagoulian, Areg; Estes, Mary; Hona, Binita; Jones, Gordon; Klein, Andi; Penttila, Seppo; Sharma, Monisha; Wilburn, Scott

    2009-05-01

    Determining polarization of a cold neutron beam to high precision is required for the next generation neutron decay correlation experiments at the SNS, such as the proposed abBA and PANDA experiments. Precision polarimetry measurements were conducted at Los Alamos National Laboratory with the goal of determining the beam polarization to the level of 10-3 or better. The cold neutrons from FP12 were polarized using optically polarized ^3He gas as a spin filter, which has a highly spin-dependent absorption cross section. A second ^ 3He spin filter was used to analyze the neutron polarization after passing through a resonant RF spin rotator. A discussion of the experiment and results will be given.

  14. A passion for precision

    ScienceCinema

    None

    2011-10-06

    For more than three decades, the quest for ever higher precision in laser spectroscopy of the simple hydrogen atom has inspired many advances in laser, optical, and spectroscopic techniques, culminating in femtosecond laser optical frequency combs  as perhaps the most precise measuring tools known to man. Applications range from optical atomic clocks and tests of QED and relativity to searches for time variations of fundamental constants. Recent experiments are extending frequency comb techniques into the extreme ultraviolet. Laser frequency combs can also control the electric field of ultrashort light pulses, creating powerful new tools for the emerging field of attosecond science.Organiser(s): L. Alvarez-Gaume / PH-THNote: * Tea & coffee will be served at 16:00.

  15. Precision disablement aiming system

    DOEpatents

    Monda, Mark J.; Hobart, Clinton G.; Gladwell, Thomas Scott

    2016-02-16

    A disrupter to a target may be precisely aimed by positioning a radiation source to direct radiation towards the target, and a detector is positioned to detect radiation that passes through the target. An aiming device is positioned between the radiation source and the target, wherein a mechanical feature of the aiming device is superimposed on the target in a captured radiographic image. The location of the aiming device in the radiographic image is used to aim a disrupter towards the target.

  16. Precise linear sun sensor

    NASA Technical Reports Server (NTRS)

    Johnston, D. D.

    1972-01-01

    An evaluation of the precise linear sun sensor relating to future mission applications was performed. The test procedures, data, and results of the dual-axis, solid-state system are included. Brief descriptions of the sensing head and of the system's operational characteristics are presented. A unique feature of the system is that multiple sensor heads with various fields of view may be used with the same electronics.

  17. Precision laser aiming system

    SciTech Connect

    Ahrens, Brandon R.; Todd, Steven N.

    2009-04-28

    A precision laser aiming system comprises a disrupter tool, a reflector, and a laser fixture. The disrupter tool, the reflector and the laser fixture are configurable for iterative alignment and aiming toward an explosive device threat. The invention enables a disrupter to be quickly and accurately set up, aligned, and aimed in order to render safe or to disrupt a target from a standoff position.

  18. High-precision image aided inertial navigation with known features: observability analysis and performance evaluation.

    PubMed

    Jiang, Weiping; Wang, Li; Niu, Xiaoji; Zhang, Quan; Zhang, Hui; Tang, Min; Hu, Xiangyun

    2014-01-01

    A high-precision image-aided inertial navigation system (INS) is proposed as an alternative to the carrier-phase-based differential Global Navigation Satellite Systems (CDGNSSs) when satellite-based navigation systems are unavailable. In this paper, the image/INS integrated algorithm is modeled by a tightly-coupled iterative extended Kalman filter (IEKF). Tightly-coupled integration ensures that the integrated system is reliable, even if few known feature points (i.e., less than three) are observed in the images. A new global observability analysis of this tightly-coupled integration is presented to guarantee that the system is observable under the necessary conditions. The analysis conclusions were verified by simulations and field tests. The field tests also indicate that high-precision position (centimeter-level) and attitude (half-degree-level)-integrated solutions can be achieved in a global reference. PMID:25330046

  19. High-Precision Image Aided Inertial Navigation with Known Features: Observability Analysis and Performance Evaluation

    PubMed Central

    Jiang, Weiping; Wang, Li; Niu, Xiaoji; Zhang, Quan; Zhang, Hui; Tang, Min; Hu, Xiangyun

    2014-01-01

    A high-precision image-aided inertial navigation system (INS) is proposed as an alternative to the carrier-phase-based differential Global Navigation Satellite Systems (CDGNSSs) when satellite-based navigation systems are unavailable. In this paper, the image/INS integrated algorithm is modeled by a tightly-coupled iterative extended Kalman filter (IEKF). Tightly-coupled integration ensures that the integrated system is reliable, even if few known feature points (i.e., less than three) are observed in the images. A new global observability analysis of this tightly-coupled integration is presented to guarantee that the system is observable under the necessary conditions. The analysis conclusions were verified by simulations and field tests. The field tests also indicate that high-precision position (centimeter-level) and attitude (half-degree-level)-integrated solutions can be achieved in a global reference. PMID:25330046

  20. Existing approaches to tight rock laboratory petrophysics: a critical review

    NASA Astrophysics Data System (ADS)

    Konoshonkin, D. V.; Parnachev, S. V.

    2015-02-01

    A review of the existing methods for tight rock porosity, saturation, and permeability determination was performed taking into account that these methods should be applicable for Bazhenov formation evaluation. The following methods were considered: Archimedes mercury immersion; mercury displacement; caliper; helium pycnometry on crushed samples; nuclear magnetic resonance; modified retort method; modified Dean-Stark extraction; pulse decay method; and pressure decay test on crushed samples. The applicability of the pressure decay test on a crushed sample for Bazhenov formation evaluation is checked experimentally with the SMP-200 commercial permeameter. All the above listed methods were combined into five protocols for tight rock petrophysical evaluation. These protocols were analyzed and compared according to the following criteria: accuracy of the results; usage experience; time of measurements; easiness of interpretation; reliability and safety; price. The obtained results revealed that the most effective protocol is the one that includes pressure pulse on a core plug for permeability determination, He pycnometry and modified retort analysis on crushed samples for porosity and saturation determination. As there were cases when the proposed protocol was less effective vs. other protocols, a special scheme was suggested in order to choose the most effective protocol for tight rock petrophysical properties evaluation in definite conditions.

  1. Effect of a tight necktie on intraocular pressure

    PubMed Central

    Teng, C; Gurses-Ozden, R; Liebmann, J M; Tello, C; Ritch, R

    2003-01-01

    Aim: To evaluate the effect of a tight necktie on intraocular pressure (IOP) measurement using Goldmann applanation tonometry. Methods: 40 eyes of 20 normal subjects and 20 open angle glaucoma patients (all male) were enrolled. IOP was measured with an open shirt collar, 3 minutes after placing a tight necktie, and 3 minutes after loosening it. All measurements were made by the same examiner. Results: Mean IOP in normal subjects increased by 2.6 (SD 3.9) mm Hg (p=0.008, paired t test; range −3 to +14 mm Hg) and in glaucoma patients by 1.0 (1.8) mm Hg (p=0.02, paired t test; range −2 to +4.5 mm Hg). In normal subjects, IOP in 12 eyes was increased by ⩾2 mm Hg and in seven eyes by ⩾4 mm Hg. In glaucoma patients, IOP in six eyes was increased by ⩾2 mm Hg and in two eyes by ⩾4 mm Hg. Conclusion: A tight necktie increases IOP in both normal subjects and glaucoma patients and could affect the diagnosis and management of glaucoma. PMID:12881330

  2. Extensor Pollicis Longus Rupture after Mini TightRope Suspensionplasty.

    PubMed

    Seetharaman, Mani; Vitale, Mark A; Desai, Kapil; Crowe, John F

    2016-05-01

    Background Arthritis of the first carpometacarpal (CMC) joint has been surgically treated in multiple ways with varying levels of success as measured by subjective and objective measures. Trapeziectomy with numerous variations in suspensionplasty comprises one of the more commonly used surgical procedures. Recently, the Mini TightRope apparatus has been utilized as a new method for achieving suspensionplasty, and as such lacks significant review of use and safety in the literature. Case Description An extensor pollicis longus (EPL) rupture following a trapeziectomy and Mini TightRope suspensionplasty for CMC arthritis of the thumb is presented. The patient successfully underwent an extensor indicis proprius (EIP) to EPL transfer to treat this complication. Literature Review There is well-established documentation of injury to the extensor tendons from orthopedic hardware such as volar locking plates. Regarding use of the Mini TightRope apparatus, guidelines for placement of the suture button include caution to place the button away from the EPL tendon to minimize the chance of tendon irritation. Additionally, FiberWire sutures, a component of the apparatus, have been shown to demonstrate soft tissue reactions with adjacent inflammatory response. Published reports on adverse events utilizing this device have been limited to case reports including an index metacarpal fracture. Clinical Relevance The aim of this case report was to cite an occurrence of EPL rupture following its use and discuss the possibilities of its direct contribution. PMID:27104081

  3. Tight junction regulates epidermal calcium ion gradient and differentiation

    SciTech Connect

    Kurasawa, Masumi; Maeda, Tetsuo; Oba, Ai; Yamamoto, Takuya; Sasaki, Hiroyuki

    2011-03-25

    Research highlights: {yields} We disrupted epidermal tight junction barrier in reconstructed epidermis. {yields} It altered Ca{sup 2+} distribution and consequentially differentiation state as well. {yields} Tight junction should affect epidermal homeostasis by maintaining Ca{sup 2+} gradient. -- Abstract: It is well known that calcium ions (Ca{sup 2+}) induce keratinocyte differentiation. Ca{sup 2+} distributes to form a vertical gradient that peaks at the stratum granulosum. It is thought that the stratum corneum (SC) forms the Ca{sup 2+} gradient since it is considered the only permeability barrier in the skin. However, the epidermal tight junction (TJ) in the granulosum has recently been suggested to restrict molecular movement to assist the SC as a secondary barrier. The objective of this study was to clarify the contribution of the TJ to Ca{sup 2+} gradient and epidermal differentiation in reconstructed human epidermis. When the epidermal TJ barrier was disrupted by sodium caprate treatment, Ca{sup 2+} flux increased and the gradient changed in ion-capture cytochemistry images. Alterations of ultrastructures and proliferation/differentiation markers revealed that both hyperproliferation and precocious differentiation occurred regionally in the epidermis. These results suggest that the TJ plays a crucial role in maintaining epidermal homeostasis by controlling the Ca{sup 2+} gradient.

  4. Tightly Coupled Inertial Navigation System/Global Positioning System (TCMIG)

    NASA Technical Reports Server (NTRS)

    Watson, Michael D.; Jackson, Kurt (Technical Monitor)

    2002-01-01

    Many NASA applications planned for execution later this decade are seeking high performance, miniaturized, low power Inertial Management Units (IMU). Much research has gone into Micro-Electro-Mechanical System (MEMS) over the past decade as a solution to these needs. While MEMS devices have proven to provide high accuracy acceleration measurements, they have not yet proven to have the accuracy required by many NASA missions in rotational measurements. Therefore, a new solution has been formulated integrating the best of all IMU technologies to address these mid-term needs in the form of a Tightly Coupled Micro Inertial Navigation System (INS)/Global Positioning System (GPS) (TCMIG). The TCMIG consists of an INS and a GPS tightly coupled by a Kalman filter executing on an embedded Field Programmable Gate Array (FPGA) processor. The INS consists of a highly integrated Interferometric Fiber Optic Gyroscope (IFOG) and a MEMS accelerometer. The IFOG utilizes a tightly wound fiber coil to reduce volume and the high level of integration and advanced optical components to reduce power. The MEMS accelerometer utilizes a newly developed deep etch process to increase the proof mass and yield a highly accurate accelerometer. The GPS receiver consists of a low power miniaturized version of the Blackjack receiver. Such an IMU configuration is ideal to meet the mid-term needs of the NASA Science Enterprises and the new launch vehicles being developed for the Space Launch Initiative (SLI).

  5. Tight junction modulation by chitosan nanoparticles: comparison with chitosan solution.

    PubMed

    Vllasaliu, Driton; Exposito-Harris, Ruth; Heras, Angeles; Casettari, Luca; Garnett, Martin; Illum, Lisbeth; Stolnik, Snow

    2010-11-15

    Present work investigates the potential of chitosan nanoparticles, formulated by the ionic gelation with tripolyphosphate (TPP), to open the cellular tight junctions and in doing so, improve the permeability of model macromolecules. A comparison is made with chitosan solution at equivalent concentrations. Initial work assessed cytotoxicity (through MTS and LDH assays) of chitosan nanoparticles and solutions on Calu-3 cells. Subsequently, a concentration of chitosan nanoparticles and solution exhibiting minimal toxicity was used to investigate the effect on TEER and macromolecular permeability across filter-cultured Calu-3 monolayer. Chitosan nanoparticles and solution were also tested for their effect on the distribution of the tight junction protein, zonnula occludens-1 (ZO-1). Chitosan nanoparticles produced a sharp and reversible decrease in TEER and increased the permeability of two FITC-dextrans (FDs), FD4 (MW 4 kDa) and FD10 (MW 10 kDa), with effects of a similar magnitude to chitosan solution. Chitosan nanoparticles produced changes in ZO-1 distribution similar to chitosan solution, indicating a tight junction effect. While there was no improvement in permeability with chitosan nanoparticles compared to solution, nanoparticles provide the potential for drug incorporation, and hence the possibility for providing controlled drug release and protection from enzymatic degradation. PMID:20727955

  6. Ab initio tight-binding Hamiltonian for transition metal dichalcogenides

    NASA Astrophysics Data System (ADS)

    Fang, Shiang; Kuate Defo, Rodrick; Shirodkar, Sharmila N.; Lieu, Simon; Tritsaris, Georgios A.; Kaxiras, Efthimios

    2015-11-01

    We present an accurate ab initio tight-binding Hamiltonian for the transition metal dichalcogenides, MoS2, MoSe2, WS2, WSe2, with a minimal basis (the d orbitals for the metal atoms and p orbitals for the chalcogen atoms) based on a transformation of the Kohn-Sham density functional theory Hamiltonian to a basis of maximally localized Wannier functions. The truncated tight-binding Hamiltonian, with only on-site, first, and partial second neighbor interactions, including spin-orbit coupling, provides a simple physical picture and the symmetry of the main band-structure features. Interlayer interactions between adjacent layers are modeled by transferable hopping terms between the chalcogen p orbitals. The full-range tight-binding Hamiltonian can be reduced to hybrid-orbital k .p effective Hamiltonians near the band extrema that capture important low-energy excitations. These ab initio Hamiltonians can serve as the starting point for applications to interacting many-body physics including optical transitions and Berry curvature of bands, of which we give some examples.

  7. High precision innovative micropump for artificial pancreas

    NASA Astrophysics Data System (ADS)

    Chappel, E.; Mefti, S.; Lettieri, G.-L.; Proennecke, S.; Conan, C.

    2014-03-01

    The concept of artificial pancreas, which comprises an insulin pump, a continuous glucose meter and a control algorithm, is a major step forward in managing patient with type 1 diabetes mellitus. The stability of the control algorithm is based on short-term precision micropump to deliver rapid-acting insulin and to specific integrated sensors able to monitor any failure leading to a loss of accuracy. Debiotech's MEMS micropump, based on the membrane pump principle, is made of a stack of 3 silicon wafers. The pumping chamber comprises a pillar check-valve at the inlet, a pumping membrane which is actuated against stop limiters by a piezo cantilever, an anti-free-flow outlet valve and a pressure sensor. The micropump inlet is tightly connected to the insulin reservoir while the outlet is in direct communication with the patient skin via a cannula. To meet the requirement of a pump dedicated to closed-loop application for diabetes care, in addition to the well-controlled displacement of the pumping membrane, the high precision of the micropump is based on specific actuation profiles that balance effect of pump elasticity in low-consumption push-pull mode.

  8. Glass ceramic ZERODUR enabling nanometer precision

    NASA Astrophysics Data System (ADS)

    Jedamzik, Ralf; Kunisch, Clemens; Nieder, Johannes; Westerhoff, Thomas

    2014-03-01

    The IC Lithography roadmap foresees manufacturing of devices with critical dimension of < 20 nm. Overlay specification of single digit nanometer asking for nanometer positioning accuracy requiring sub nanometer position measurement accuracy. The glass ceramic ZERODUR® is a well-established material in critical components of microlithography wafer stepper and offered with an extremely low coefficient of thermal expansion (CTE), the tightest tolerance available on market. SCHOTT is continuously improving manufacturing processes and it's method to measure and characterize the CTE behavior of ZERODUR® to full fill the ever tighter CTE specification for wafer stepper components. In this paper we present the ZERODUR® Lithography Roadmap on the CTE metrology and tolerance. Additionally, simulation calculations based on a physical model are presented predicting the long term CTE behavior of ZERODUR® components to optimize dimensional stability of precision positioning devices. CTE data of several low thermal expansion materials are compared regarding their temperature dependence between - 50°C and + 100°C. ZERODUR® TAILORED 22°C is full filling the tight CTE tolerance of +/- 10 ppb / K within the broadest temperature interval compared to all other materials of this investigation. The data presented in this paper explicitly demonstrates the capability of ZERODUR® to enable the nanometer precision required for future generation of lithography equipment and processes.

  9. Instrument Attitude Precision Control

    NASA Technical Reports Server (NTRS)

    Juang, Jer-Nan

    2004-01-01

    A novel approach is presented in this paper to analyze attitude precision and control for an instrument gimbaled to a spacecraft subject to an internal disturbance caused by a moving component inside the instrument. Nonlinear differential equations of motion for some sample cases are derived and solved analytically to gain insight into the influence of the disturbance on the attitude pointing error. A simple control law is developed to eliminate the instrument pointing error caused by the internal disturbance. Several cases are presented to demonstrate and verify the concept presented in this paper.

  10. Precise Measurement for Manufacturing

    NASA Technical Reports Server (NTRS)

    2003-01-01

    A metrology instrument known as PhaseCam supports a wide range of applications, from testing large optics to controlling factory production processes. This dynamic interferometer system enables precise measurement of three-dimensional surfaces in the manufacturing industry, delivering speed and high-resolution accuracy in even the most challenging environments.Compact and reliable, PhaseCam enables users to make interferometric measurements right on the factory floor. The system can be configured for many different applications, including mirror phasing, vacuum/cryogenic testing, motion/modal analysis, and flow visualization.

  11. Precision Robotic Assembly Machine

    ScienceCinema

    None

    2010-09-01

    The world's largest laser system is the National Ignition Facility (NIF), located at Lawrence Livermore National Laboratory. NIF's 192 laser beams are amplified to extremely high energy, and then focused onto a tiny target about the size of a BB, containing frozen hydrogen gas. The target must be perfectly machined to incredibly demanding specifications. The Laboratory's scientists and engineers have developed a device called the "Precision Robotic Assembly Machine" for this purpose. Its unique design won a prestigious R&D-100 award from R&D Magazine.

  12. Precision mass measurements

    NASA Astrophysics Data System (ADS)

    Gläser, M.; Borys, M.

    2009-12-01

    Mass as a physical quantity and its measurement are described. After some historical remarks, a short summary of the concept of mass in classical and modern physics is given. Principles and methods of mass measurements, for example as energy measurement or as measurement of weight forces and forces caused by acceleration, are discussed. Precision mass measurement by comparing mass standards using balances is described in detail. Measurement of atomic masses related to 12C is briefly reviewed as well as experiments and recent discussions for a future new definition of the kilogram, the SI unit of mass.

  13. Precision Pointing System Development

    SciTech Connect

    BUGOS, ROBERT M.

    2003-03-01

    The development of precision pointing systems has been underway in Sandia's Electronic Systems Center for over thirty years. Important areas of emphasis are synthetic aperture radars and optical reconnaissance systems. Most applications are in the aerospace arena, with host vehicles including rockets, satellites, and manned and unmanned aircraft. Systems have been used on defense-related missions throughout the world. Presently in development are pointing systems with accuracy goals in the nanoradian regime. Future activity will include efforts to dramatically reduce system size and weight through measures such as the incorporation of advanced materials and MEMS inertial sensors.

  14. Precision Robotic Assembly Machine

    SciTech Connect

    2009-08-14

    The world's largest laser system is the National Ignition Facility (NIF), located at Lawrence Livermore National Laboratory. NIF's 192 laser beams are amplified to extremely high energy, and then focused onto a tiny target about the size of a BB, containing frozen hydrogen gas. The target must be perfectly machined to incredibly demanding specifications. The Laboratory's scientists and engineers have developed a device called the "Precision Robotic Assembly Machine" for this purpose. Its unique design won a prestigious R&D-100 award from R&D Magazine.

  15. Precision electroweak measurements

    SciTech Connect

    Demarteau, M.

    1996-11-01

    Recent electroweak precision measurements fro {ital e}{sup +}{ital e}{sup -} and {ital p{anti p}} colliders are presented. Some emphasis is placed on the recent developments in the heavy flavor sector. The measurements are compared to predictions from the Standard Model of electroweak interactions. All results are found to be consistent with the Standard Model. The indirect constraint on the top quark mass from all measurements is in excellent agreement with the direct {ital m{sub t}} measurements. Using the world`s electroweak data in conjunction with the current measurement of the top quark mass, the constraints on the Higgs` mass are discussed.

  16. Precision measurements in supersymmetry

    SciTech Connect

    Feng, J.L.

    1995-05-01

    Supersymmetry is a promising framework in which to explore extensions of the standard model. If candidates for supersymmetric particles are found, precision measurements of their properties will then be of paramount importance. The prospects for such measurements and their implications are the subject of this thesis. If charginos are produced at the LEP II collider, they are likely to be one of the few available supersymmetric signals for many years. The author considers the possibility of determining fundamental supersymmetry parameters in such a scenario. The study is complicated by the dependence of observables on a large number of these parameters. He proposes a straightforward procedure for disentangling these dependences and demonstrate its effectiveness by presenting a number of case studies at representative points in parameter space. In addition to determining the properties of supersymmetric particles, precision measurements may also be used to establish that newly-discovered particles are, in fact, supersymmetric. Supersymmetry predicts quantitative relations among the couplings and masses of superparticles. The author discusses tests of such relations at a future e{sup +}e{sup {minus}} linear collider, using measurements that exploit the availability of polarizable beams. Stringent tests of supersymmetry from chargino production are demonstrated in two representative cases, and fermion and neutralino processes are also discussed.

  17. Precision flyer initiator

    DOEpatents

    Frank, Alan M.; Lee, Ronald S.

    1998-01-01

    A precision flyer initiator forms a substantially spherical detonation wave in a high explosive (HE) pellet. An explosive driver, such as a detonating cord, a wire bridge circuit or a small explosive, is detonated. A flyer material is sandwiched between the explosive driver and an end of a barrel that contains an inner channel. A projectile or "flyer" is sheared from the flyer material by the force of the explosive driver and projected through the inner channel. The flyer than strikes the HE pellet, which is supported above a second end of the barrel by a spacer ring. A gap or shock decoupling material delays the shock wave in the barrel from predetonating the HE pellet before the flyer. A spherical detonation wave is formed in the HE pellet. Thus, a shock wave traveling through the barrel fails to reach the HE pellet before the flyer strikes the HE pellet. The precision flyer initiator can be used in mining devices, well-drilling devices and anti-tank devices.

  18. Precision muon physics

    NASA Astrophysics Data System (ADS)

    Gorringe, T. P.; Hertzog, D. W.

    2015-09-01

    The muon is playing a unique role in sub-atomic physics. Studies of muon decay both determine the overall strength and establish the chiral structure of weak interactions, as well as setting extraordinary limits on charged-lepton-flavor-violating processes. Measurements of the muon's anomalous magnetic moment offer singular sensitivity to the completeness of the standard model and the predictions of many speculative theories. Spectroscopy of muonium and muonic atoms gives unmatched determinations of fundamental quantities including the magnetic moment ratio μμ /μp, lepton mass ratio mμ /me, and proton charge radius rp. Also, muon capture experiments are exploring elusive features of weak interactions involving nucleons and nuclei. We will review the experimental landscape of contemporary high-precision and high-sensitivity experiments with muons. One focus is the novel methods and ingenious techniques that achieve such precision and sensitivity in recent, present, and planned experiments. Another focus is the uncommonly broad and topical range of questions in atomic, nuclear and particle physics that such experiments explore.

  19. Precision Joining Center

    SciTech Connect

    Powell, J.W.; Westphal, D.A.

    1991-08-01

    A workshop to obtain input from industry on the establishment of the Precision Joining Center (PJC) was held on July 10--12, 1991. The PJC is a center for training Joining Technologists in advanced joining techniques and concepts in order to promote the competitiveness of US industry. The center will be established as part of the DOE Defense Programs Technology Commercialization Initiative, and operated by EG G Rocky Flats in cooperation with the American Welding Society and the Colorado School of Mines Center for Welding and Joining Research. The overall objectives of the workshop were to validate the need for a Joining Technologists to fill the gap between the welding operator and the welding engineer, and to assure that the PJC will train individuals to satisfy that need. The consensus of the workshop participants was that the Joining Technologist is a necessary position in industry, and is currently used, with some variation, by many companies. It was agreed that the PJC core curriculum, as presented, would produce a Joining Technologist of value to industries that use precision joining techniques. The advantage of the PJC would be to train the Joining Technologist much more quickly and more completely. The proposed emphasis of the PJC curriculum on equipment intensive and hands-on training was judged to be essential.

  20. Progressive Precision Surface Design

    SciTech Connect

    Duchaineau, M; Joy, KJ

    2002-01-11

    We introduce a novel wavelet decomposition algorithm that makes a number of powerful new surface design operations practical. Wavelets, and hierarchical representations generally, have held promise to facilitate a variety of design tasks in a unified way by approximating results very precisely, thus avoiding a proliferation of undergirding mathematical representations. However, traditional wavelet decomposition is defined from fine to coarse resolution, thus limiting its efficiency for highly precise surface manipulation when attempting to create new non-local editing methods. Our key contribution is the progressive wavelet decomposition algorithm, a general-purpose coarse-to-fine method for hierarchical fitting, based in this paper on an underlying multiresolution representation called dyadic splines. The algorithm requests input via a generic interval query mechanism, allowing a wide variety of non-local operations to be quickly implemented. The algorithm performs work proportionate to the tiny compressed output size, rather than to some arbitrarily high resolution that would otherwise be required, thus increasing performance by several orders of magnitude. We describe several design operations that are made tractable because of the progressive decomposition. Free-form pasting is a generalization of the traditional control-mesh edit, but for which the shape of the change is completely general and where the shape can be placed using a free-form deformation within the surface domain. Smoothing and roughening operations are enhanced so that an arbitrary loop in the domain specifies the area of effect. Finally, the sculpting effect of moving a tool shape along a path is simulated.

  1. Precision flyer initiator

    DOEpatents

    Frank, A.M.; Lee, R.S.

    1998-05-26

    A precision flyer initiator forms a substantially spherical detonation wave in a high explosive (HE) pellet. An explosive driver, such as a detonating cord, a wire bridge circuit or a small explosive, is detonated. A flyer material is sandwiched between the explosive driver and an end of a barrel that contains an inner channel. A projectile or ``flyer`` is sheared from the flyer material by the force of the explosive driver and projected through the inner channel. The flyer than strikes the HE pellet, which is supported above a second end of the barrel by a spacer ring. A gap or shock decoupling material delays the shock wave in the barrel from predetonating the HE pellet before the flyer. A spherical detonation wave is formed in the HE pellet. Thus, a shock wave traveling through the barrel fails to reach the HE pellet before the flyer strikes the HE pellet. The precision flyer initiator can be used in mining devices, well-drilling devices and anti-tank devices. 10 figs.

  2. Transferable tight-binding parameters: An application to Ni and Ni-Al alloys

    SciTech Connect

    Sluiter, M.H.F.; Singh, P.P.

    1993-07-01

    Two approaches for obtaining tight-binding parameters for metallic alloys are compared and contrasted with special regard for the application to large scale simulations such as may occur in tight-binding molecular dynamics studies.

  3. Production of ammonium by Helicobacter pylori mediates occludin processing and disruption of tight junctions in Caco-2 cells.

    PubMed

    Lytton, Simon D; Fischer, Wolfgang; Nagel, Wolfram; Haas, Rainer; Beck, Franz X

    2005-10-01

    Tight junctions, paracellular permeability barriers that define epithelial cell polarity, play an essential role in transepithelial transport, cell-cell adhesion and lymphocyte transmigration. They are also important for the maintenance of innate immune defence and intestinal antigen uptake. Ammonium (NH4+) is elevated in the gastric aspirates of Helicobacter pylori-infected patients and has been implicated in the disruption of tight-junction functional integrity and the induction of gastric mucosal damage during H. pylori infection. The precise mechanism of the effect of ammonium and the molecular targets of ammonium in host tissue are not yet identified. To study the effects of ammonium on epithelial tight junctions, the human colon carcinoma cell line Caco-2 was cultured on permeable supports and the transepithelial resistance (TER) was measured at different time intervals following exposure to ammonium salts or H. pylori-derived ammonium. A biphasic response to treatment with ammonium was found. Acute exposure to ammonium salts or NH3/NH4+ derived from urea metabolism by wild-type H. pylori resulted in a 20-30 % decrease in TER. After 24 h, the NH4Cl-treated cells showed a partial recovery of TER. In contrast, the control culture, or cultures that were exposed to supernatants derived from urease-deficient H. pylori, showed no significant decrease in TER. Occludin-specific immunoblots revealed the expression of a low-molecular-weight form of occludin of 42 kDa upon NH3/NH4+ exposure. The results indicate that modulation of tight-junction function by H. pylori is ammonium-dependent and linked to the accumulation of a low-molecular-weight and detergent-soluble form of occludin. PMID:16207910

  4. Tight-binding approach to strain-dependent DNA electronics

    NASA Astrophysics Data System (ADS)

    Malakooti, Sadeq; Hedin, Eric; Joe, Yong

    2013-07-01

    Small mechanical strain perturbations are considered in calculations of the poly(G)-poly(C) DNA molecular electronic structure, using a tight-binding framework in conjunction with the theories of Slater-Koster and linear elasticity. Results reveal a strain-induced band gap for DNA which is linearly dependent on the induced strain. Local density of states calculations expose that the contribution of the guanine-cytosine base pairs in the charge transport mechanism is significantly enhanced relative to the backbones when DNA is compressed. Transport investigations also disclose a strain-induced metal-semiconductor transition for the DNA molecule, which suggests possible potential uses for sensing applications.

  5. Tight Lower Bound for Percolation Threshold on an Infinite Graph

    NASA Astrophysics Data System (ADS)

    Hamilton, Kathleen E.; Pryadko, Leonid P.

    2014-11-01

    We construct a tight lower bound for the site percolation threshold on an infinite graph, which becomes exact for an infinite tree. The bound is given by the inverse of the maximal eigenvalue of the Hashimoto matrix used to count nonbacktracking walks on the original graph. Our bound always exceeds the inverse spectral radius of the graph's adjacency matrix, and it is also generally tighter than the existing bound in terms of the maximum degree. We give a constructive proof for existence of such an eigenvalue in the case of a connected infinite quasitransitive graph, a graph-theoretic analog of a translationally invariant system.

  6. Tight glycemic control in the ICU - is the earth flat?

    PubMed

    Steil, Garry M; Agus, Michael S D

    2014-01-01

    Tight glycemic control in the ICU has been shown to reduce mortality in some but not all prospective randomized control trials. Confounding the interpretation of these studies are differences in how the control was achieved and underlying incidence of hypoglycemia, which can be expected to be affected by the introduction of continuous glucose monitoring (CGM). In this issue of Critical Care, a consensus panel provides a list of the research priorities they believe are needed for CGM to become routine practice in the ICU. We reflect on these recommendations and consider the implications for using CGM today. PMID:25041720

  7. Effects of gastrocnemius tightness on forefoot during gait.

    PubMed

    Cazeau, Cyrille; Stiglitz, Yves

    2014-12-01

    The gastrocnemius is the main muscle of the posterior compartment of the leg. As a biarticular muscle it has specific biomechanical propertiess. This article discusses these properties combining the major biomechanical topics of anatomy, dynamics, kinetics, and electromyography. This muscle is remarkable in that it has very low energy consumption and very high mechanical efficacy. In addition to the biomechanical features, the consequences of its tightness are discussed. The dysfunction also appears in all the biomechanical topics and clarifies the reasons of the location of symptoms in the midfoot and on the plantar aspect of the forefoot. PMID:25456714

  8. Materials processing with a tightly focused femtosecond laser vortex pulse.

    PubMed

    Hnatovsky, Cyril; Shvedov, Vladlen G; Krolikowski, Wieslaw; Rode, Andrei V

    2010-10-15

    In this Letter we present the first (to our knowledge) demonstration of material modification using tightly focused single femtosecond laser vortex pulses. Double-charge femtosecond vortices were synthesized with a polarization-singularity beam converter based on light propagation in a uniaxial anisotropic medium and then focused using moderate- and high-NA optics (viz., NA=0.45 and 0.9) to ablate fused silica and soda-lime glass. By controlling the pulse energy, we consistently machine micrometer-size ring-shaped structures with <100nm uniform groove thickness. PMID:20967085

  9. Tight-binding molecular-dynamics simulation of buckyball collisions

    SciTech Connect

    Zhang, B.L.; Wang, C.Z.; Chan, C.T.; Ho, K.M. )

    1993-04-01

    The collisions between C[sub 60] molecules are studied by tight-binding molecular-dynamics simulations. We observe three different regimes of behavior as the collisions become more and more energetic: bouncing, fusion, and fragmentation. The critical energies for fusion and fragmentation as well as details of the energy transfer during the collision process for the bouncing regime are investigated. The collisions at several specific energies and orientations produce interesting novel molecules, such as small baby cages, caps, and even a Russian-Doll molecule in which a small cage is trapped in a bigger one. 28 refs., 5 figs., 2 tabs.

  10. Tight-binding model for hydrogen-silicon interactions

    SciTech Connect

    Min, B.J.; Lee, Y.H.; Wang, C.Z.; Chan, C.T.; Ho, K.M. Department of Physics and Astronomy, Ames Laboratory, Iowa State University, Ames, Iowa 50011 )

    1992-03-15

    We have developed an empirical tight-binding model for use in molecular-dynamics simulations to study hydrogen-silicon systems. The hydrogen-silicon interaction is constructed to reproduce the electronic energy levels and vibration frequencies of silane (SiH{sub 4}). Further use of the model in the studies of disilane (Si{sub 2}H{sub 6}) and of hydrogen on the Si(111) surface also yields results in good agreement with first-principles calculations and experiments.

  11. Strained graphene: tight-binding and density functional calculations

    NASA Astrophysics Data System (ADS)

    Ribeiro, R. M.; Pereira, Vitor M.; Peres, N. M. R.; Briddon, P. R.; Castro Neto, A. H.

    2009-11-01

    We determine the band structure of graphene under strain using density functional calculations. The ab initio band structure is then used to extract the best fit to the tight-binding hopping parameters used in a recent microscopic model of strained graphene. It is found that the hopping parameters may increase or decrease upon increasing strain, depending on the orientation of the applied stress. The fitted values are compared with an available parameterization for the dependence of the orbital overlap on the distance separating the two carbon atoms. It is also found that strain does not induce a gap in graphene, at least for deformations up to 10%.

  12. Precision Joining Center

    NASA Technical Reports Server (NTRS)

    Powell, John W.

    1991-01-01

    The establishment of a Precision Joining Center (PJC) is proposed. The PJC will be a cooperatively operated center with participation from U.S. private industry, the Colorado School of Mines, and various government agencies, including the Department of Energy's Nuclear Weapons Complex (NWC). The PJC's primary mission will be as a training center for advanced joining technologies. This will accomplish the following objectives: (1) it will provide an effective mechanism to transfer joining technology from the NWC to private industry; (2) it will provide a center for testing new joining processes for the NWC and private industry; and (3) it will provide highly trained personnel to support advance joining processes for the NWC and private industry.

  13. Precision spectroscopy of Helium

    SciTech Connect

    Cancio, P.; Giusfredi, G.; Mazzotti, D.; De Natale, P.; De Mauro, C.; Krachmalnicoff, V.; Inguscio, M.

    2005-05-05

    Accurate Quantum-Electrodynamics (QED) tests of the simplest bound three body atomic system are performed by precise laser spectroscopic measurements in atomic Helium. In this paper, we present a review of measurements between triplet states at 1083 nm (23S-23P) and at 389 nm (23S-33P). In 4He, such data have been used to measure the fine structure of the triplet P levels and, then, to determine the fine structure constant when compared with equally accurate theoretical calculations. Moreover, the absolute frequencies of the optical transitions have been used for Lamb-shift determinations of the levels involved with unprecedented accuracy. Finally, determination of the He isotopes nuclear structure and, in particular, a measurement of the nuclear charge radius, are performed by using hyperfine structure and isotope-shift measurements.

  14. Evaluation of the Sparton tight-tolerance AXBT

    SciTech Connect

    Boyd, J.D.; Linzell, R.S. |

    1993-12-01

    Forty-six near-simultaneous pairs of conductivity - temperature - depth (CTD) and Sparton `tight tolerance` air expendable bathythermograph (AXBT) temperature profiles were obtained in summer 1991 from a location in the Sargasso Sea. The data were analyzed to assess the temperature and depth accuracies of the Sparton AXBTs. The tight-tolerance criterion was not achieved using the manufacturer`s equations but may have been achieved using customized equations computed from the CTD data. The temperature data from the customized equations had a one standard deviation error of 0.13 C. A customized elapsed fall time-to-depth conversion equation was found to be z = 1.620t - 2.2384 x 10(exp -4) t(exp 2) + 1.291 x 10(exp -7) t(exp 3), with z the depth in meters and t the elapsed fall time after probe release in seconds. The standard deviation of the depth error was about 5 m; a rule of thumb for estimating maximum bounds on the depth error below 100 m could be expressed as +/-2% of depth or +/- 10 m, whichever is greater. This equation gave greater depth accuracy than either the manufacturer`s supplied equation or the navy standard equation.

  15. Evaluation of the Sparton tight-tolerance AXBT

    NASA Technical Reports Server (NTRS)

    Boyd, Janice D.; Linzell, Robert S.

    1993-01-01

    Forty-six near-simultaneous pairs of conductivity - temperature - depth (CTD) and Sparton 'tight tolerance' air expendable bathythermograph (AXBT) temperature profiles were obtained in summer 1991 from a location in the Sargasso Sea. The data were analyzed to assess the temperature and depth accuracies of the Sparton AXBTs. The tight-tolerance criterion was not achieved using the manufacturer's equations but may have been achieved using customized equations computed from the CTD data. The temperature data from the customized equations had a one standard deviation error of 0.13 C. A customized elapsed fall time-to-depth conversion equation was found to be z = 1.620t - 2.2384 x 10(exp -4) t(exp 2) + 1.291 x 10(exp -7) t(exp 3), with z the depth in meters and t the elapsed fall time after probe release in seconds. The standard deviation of the depth error was about 5 m; a rule of thumb for estimating maximum bounds on the depth error below 100 m could be expressed as +/-2% of depth or +/- 10 m, whichever is greater. This equation gave greater depth accuracy than either the manufacturer's supplied equation or the navy standard equation.

  16. Instantaneous Observability of Tightly Coupled SINS/GPS during Maneuvers

    PubMed Central

    Jiang, Junxiang; Yu, Fei; Lan, Haiyu; Dong, Qianhui

    2016-01-01

    The tightly coupled strapdown inertial navigation system (SINS)/global position system (GPS) has been widely used. The system observability determines whether the system state can be estimated by a filter efficiently or not. In this paper, the observability analysis of a two-channel and a three-channel tightly coupled SINS/GPS are performed, respectively, during arbitrary translational maneuvers and angle maneuvers, where the translational maneuver and angle maneuver are modeled. A novel instantaneous observability matrix (IOM) based on a reconstructed psi-angle model is proposed to make the theoretical analysis simpler, which starts from the observability definition directly. Based on the IOM, a series of theoretical analysis are performed. Analysis results show that almost all kinds of translational maneuver and angle maneuver can make a three-channel system instantaneously observable, but there is no one translational maneuver or angle maneuver can make a two-channel system instantaneously observable. The system’s performance is investigated when the system is not instantaneously observable. A series of simulation studies based on EKF are performed to confirm the analytic conclusions. PMID:27240369

  17. Instantaneous Observability of Tightly Coupled SINS/GPS during Maneuvers.

    PubMed

    Jiang, Junxiang; Yu, Fei; Lan, Haiyu; Dong, Qianhui

    2016-01-01

    The tightly coupled strapdown inertial navigation system (SINS)/global position system (GPS) has been widely used. The system observability determines whether the system state can be estimated by a filter efficiently or not. In this paper, the observability analysis of a two-channel and a three-channel tightly coupled SINS/GPS are performed, respectively, during arbitrary translational maneuvers and angle maneuvers, where the translational maneuver and angle maneuver are modeled. A novel instantaneous observability matrix (IOM) based on a reconstructed psi-angle model is proposed to make the theoretical analysis simpler, which starts from the observability definition directly. Based on the IOM, a series of theoretical analysis are performed. Analysis results show that almost all kinds of translational maneuver and angle maneuver can make a three-channel system instantaneously observable, but there is no one translational maneuver or angle maneuver can make a two-channel system instantaneously observable. The system's performance is investigated when the system is not instantaneously observable. A series of simulation studies based on EKF are performed to confirm the analytic conclusions. PMID:27240369

  18. Tricellulin deficiency affects tight junction architecture and cochlear hair cells

    PubMed Central

    Nayak, Gowri; Lee, Sue I.; Yousaf, Rizwan; Edelmann, Stephanie E.; Trincot, Claire; Van Itallie, Christina M.; Sinha, Ghanshyam P.; Rafeeq, Maria; Jones, Sherri M.; Belyantseva, Inna A.; Anderson, James M.; Forge, Andrew; Frolenkov, Gregory I.; Riazuddin, Saima

    2013-01-01

    The two compositionally distinct extracellular cochlear fluids, endolymph and perilymph, are separated by tight junctions that outline the scala media and reticular lamina. Mutations in TRIC (also known as MARVELD2), which encodes a tricellular tight junction protein known as tricellulin, lead to nonsyndromic hearing loss (DFNB49). We generated a knockin mouse that carries a mutation orthologous to the TRIC coding mutation linked to DFNB49 hearing loss in humans. Tricellulin was absent from the tricellular junctions in the inner ear epithelia of the mutant animals, which developed rapidly progressing hearing loss accompanied by loss of mechanosensory cochlear hair cells, while the endocochlear potential and paracellular permeability of a biotin-based tracer in the stria vascularis were unaltered. Freeze-fracture electron microscopy revealed disruption of the strands of intramembrane particles connecting bicellular and tricellular junctions in the inner ear epithelia of tricellulin-deficient mice. These ultrastructural changes may selectively affect the paracellular permeability of ions or small molecules, resulting in a toxic microenvironment for cochlear hair cells. Consistent with this hypothesis, hair cell loss was rescued in tricellulin-deficient mice when generation of normal endolymph was inhibited by a concomitant deletion of the transcription factor, Pou3f4. Finally, comprehensive phenotypic screening showed a broader pathological phenotype in the mutant mice, which highlights the non-redundant roles played by tricellulin. PMID:23979167

  19. Gas Flow Tightly Coupled to Elastoplastic Geomechanics for Tight- and Shale-Gas Reservoirs: Material Failure and Enhanced Permeability

    DOE PAGESBeta

    Kim, Jihoon; Moridis, George J.

    2014-12-01

    We investigate coupled flow and geomechanics in gas production from extremely low permeability reservoirs such as tight and shale gas reservoirs, using dynamic porosity and permeability during numerical simulation. In particular, we take the intrinsic permeability as a step function of the status of material failure, and the permeability is updated every time step. We consider gas reservoirs with the vertical and horizontal primary fractures, employing the single and dynamic double porosity (dual continuum) models. We modify the multiple porosity constitutive relations for modeling the double porous continua for flow and geomechanics. The numerical results indicate that production of gasmore » causes redistribution of the effective stress fields, increasing the effective shear stress and resulting in plasticity. Shear failure occurs not only near the fracture tips but also away from the primary fractures, which indicates generation of secondary fractures. These secondary fractures increase the permeability significantly, and change the flow pattern, which in turn causes a change in distribution of geomechanical variables. From various numerical tests, we find that shear failure is enhanced by a large pressure drop at the production well, high Biot's coefficient, low frictional and dilation angles. Smaller spacing between the horizontal wells also contributes to faster secondary fracturing. When the dynamic double porosity model is used, we observe a faster evolution of the enhanced permeability areas than that obtained from the single porosity model, mainly due to a higher permeability of the fractures in the double porosity model. These complicated physics for stress sensitive reservoirs cannot properly be captured by the uncoupled or flow-only simulation, and thus tightly coupled flow and geomechanical models are highly recommended to accurately describe the reservoir behavior during gas production in tight and shale gas reservoirs and to smartly design

  20. Gas Flow Tightly Coupled to Elastoplastic Geomechanics for Tight- and Shale-Gas Reservoirs: Material Failure and Enhanced Permeability

    SciTech Connect

    Kim, Jihoon; Moridis, George J.

    2014-12-01

    We investigate coupled flow and geomechanics in gas production from extremely low permeability reservoirs such as tight and shale gas reservoirs, using dynamic porosity and permeability during numerical simulation. In particular, we take the intrinsic permeability as a step function of the status of material failure, and the permeability is updated every time step. We consider gas reservoirs with the vertical and horizontal primary fractures, employing the single and dynamic double porosity (dual continuum) models. We modify the multiple porosity constitutive relations for modeling the double porous continua for flow and geomechanics. The numerical results indicate that production of gas causes redistribution of the effective stress fields, increasing the effective shear stress and resulting in plasticity. Shear failure occurs not only near the fracture tips but also away from the primary fractures, which indicates generation of secondary fractures. These secondary fractures increase the permeability significantly, and change the flow pattern, which in turn causes a change in distribution of geomechanical variables. From various numerical tests, we find that shear failure is enhanced by a large pressure drop at the production well, high Biot's coefficient, low frictional and dilation angles. Smaller spacing between the horizontal wells also contributes to faster secondary fracturing. When the dynamic double porosity model is used, we observe a faster evolution of the enhanced permeability areas than that obtained from the single porosity model, mainly due to a higher permeability of the fractures in the double porosity model. These complicated physics for stress sensitive reservoirs cannot properly be captured by the uncoupled or flow-only simulation, and thus tightly coupled flow and geomechanical models are highly recommended to accurately describe the reservoir behavior during gas production in tight and shale gas reservoirs and to smartly design production

  1. Tight Fits for Americas Next Moon Rocket, Ares V

    NASA Technical Reports Server (NTRS)

    Jaap, John; Fisher, Wyatt; Richardson, Lea

    2010-01-01

    America has begun the development of a new heavy lift rocket which will enable humans to return to the moon and reach even farther destinations. Five decades ago, the National Aeronautics and Space Administration designed a system (called Saturn/Apollo) to carry men to the moon and back; the rocket which boosted them to the moon was the Saturn V. Saturn V was huge relative to contemporary rockets and is still the largest rocket ever launched. The new moon rocket is called Ares V. It will insert 40% more payload into low earth orbit than Saturn V; and after docking with the crew spacecraft, it will insert 50% more payload onto the translunar trajectory than Saturn V. The current design of Ares V calls for two liquid-fueled stages and 2 "strap-on" solid rockets. The solid rockets are extended-length versions of the solid rockets used on the Shuttle. The diameter of the liquid stages is at least as large as the first stage of the Saturn V; the height of the lower liquid stage (called the core stage) is longer than the external tank of the Shuttle. Huge rockets require huge infrastructure and, during the Saturn/Apollo era, America invested significantly in manufacturing, assembly and launch facilities which are still in use today. Since the Saturn/Apollo era, America has invested in additional infrastructure for the Shuttle program. Ares V must utilize this existing infrastructure, with reasonable modifications. Building a rocket with 50% more capability in the same buildings, testing it in the same test stands, shipping on the same canals under the same bridges, assembling it in the same building, rolling it to the pad on the same crawler, and launching it from the same launch pad is an engineering and logistics challenge which goes hand-in-hand with designing the structure, tanks, turbines, engines, software, etc. necessary to carry such a large payload to earth orbit and to the moon. This paper quantitatively discusses the significant "tight fits" that are

  2. MANAGING TIGHT BINDING RECEPTORS FOR NEW SPEARATIONS TECHNOLOGIES

    SciTech Connect

    DARYLE H BUSCH RICHARD S GIVENS

    2004-12-10

    Much of the earth's pollution involves compounds of the metallic elements, including actinides, strontium, cesium, technetium, and RCRA metals. Metal ions bind to molecules called ligands, which are the molecular tools that can manipulate the metal ions under most conditions. This DOE-EMSP sponsored program strives (1) to provide the foundations for using the most powerful ligands in transformational separations technologies and (2) to produce seminal examples of their applications to separations appropriate to the DOE EM mission. These ultra tight-binding ligands can capture metal ions in the most competitive of circumstances (from mineralized sites, lesser ligands, and even extremely dilute solutions), but they react so slowly that they are useless in traditional separations methodologies. Two attacks on this problem are underway. The first accommodates to the challenging molecular lethargy by developing a seminal slow separations methodology termed the soil poultice. The second designs ligands that are only tight-binding while wrapped around the targeted metal ion, but can be put in place by switch-binding and removed by switch-release. We envision a kind of molecular switching process to accelerate the union between metal ion and tight-binding ligand. Molecular switching processes are suggested for overcoming the slow natural equilibration rate with which ultra tight-binding ligands combine with metal ions. Ligands that bind relatively weakly combine with metal ions rapidly, so the trick is to convert a ligand from a weak, rapidly binding species to a powerful, slow releasing ligand--during the binding of the ligand to the metal ion. Such switch-binding ligands must react with themselves, and the reaction must take place under the influence of the metal ion. For example, our generation 1 ligands showed that a well-designed linear ligand with ends that readily combine, forms a cyclic molecule when it wraps around a metal ion. Our generation 2 ligands are even

  3. Precision grid and hand motion for accurate needle insertion in brachytherapy

    SciTech Connect

    McGill, Carl S.; Schwartz, Jonathon A.; Moore, Jason Z.; McLaughlin, Patrick W.; Shih, Albert J.

    2011-08-15

    Purpose: In prostate brachytherapy, a grid is used to guide a needle tip toward a preplanned location within the tissue. During insertion, the needle deflects en route resulting in target misplacement. In this paper, 18-gauge needle insertion experiments into phantom were performed to test effects of three parameters, which include the clearance between the grid hole and needle, the thickness of the grid, and the needle insertion speed. Measurement apparatus that consisted of two datum surfaces and digital depth gauge was developed to quantify needle deflections. Methods: The gauge repeatability and reproducibility (GR and R) test was performed on the measurement apparatus, and it proved to be capable of measuring a 2 mm tolerance from the target. Replicated experiments were performed on a 2{sup 3} factorial design (three parameters at two levels) and analysis included averages and standard deviation along with an analysis of variance (ANOVA) to find significant single and two-way interaction factors. Results: Results showed that grid with tight clearance hole and slow needle speed increased precision and accuracy of needle insertion. The tight grid was vital to enhance precision and accuracy of needle insertion for both slow and fast insertion speed; additionally, at slow speed the tight, thick grid improved needle precision and accuracy. Conclusions: In summary, the tight grid is important, regardless of speed. The grid design, which shows the capability to reduce the needle deflection in brachytherapy procedures, can potentially be implemented in the brachytherapy procedure.

  4. GEOLOGIC ASPECTS OF TIGHT GAS RESERVOIRS IN THE ROCKY MOUNTAIN REGION.

    USGS Publications Warehouse

    Spencer, Charles W.

    1985-01-01

    The authors describe some geologic characteristics of tight gas reservoirs in the Rocky Mountain region. These reservoirs usually have an in-situ permeability to gas of 0. 1 md or less and can be classified into four general geologic and engineering categories: (1) marginal marine blanket, (2) lenticular, (3) chalk, and (4) marine blanket shallow. Microscopic study of pore/permeability relationships indicates the existence of two varieties of tight reservoirs. One variety is tight because of the fine grain size of the rock. The second variety is tight because the rock is relatively tightly cemented and the pores are poorly connected by small pore throats and capillaries.

  5. Prompt and Precise Prototyping

    NASA Technical Reports Server (NTRS)

    2003-01-01

    For Sanders Design International, Inc., of Wilton, New Hampshire, every passing second between the concept and realization of a product is essential to succeed in the rapid prototyping industry where amongst heavy competition, faster time-to-market means more business. To separate itself from its rivals, Sanders Design aligned with NASA's Marshall Space Flight Center to develop what it considers to be the most accurate rapid prototyping machine for fabrication of extremely precise tooling prototypes. The company's Rapid ToolMaker System has revolutionized production of high quality, small-to-medium sized prototype patterns and tooling molds with an exactness that surpasses that of computer numerically-controlled (CNC) machining devices. Created with funding and support from Marshall under a Small Business Innovation Research (SBIR) contract, the Rapid ToolMaker is a dual-use technology with applications in both commercial and military aerospace fields. The advanced technology provides cost savings in the design and manufacturing of automotive, electronic, and medical parts, as well as in other areas of consumer interest, such as jewelry and toys. For aerospace applications, the Rapid ToolMaker enables fabrication of high-quality turbine and compressor blades for jet engines on unmanned air vehicles, aircraft, and missiles.

  6. Arrival Metering Precision Study

    NASA Technical Reports Server (NTRS)

    Prevot, Thomas; Mercer, Joey; Homola, Jeffrey; Hunt, Sarah; Gomez, Ashley; Bienert, Nancy; Omar, Faisal; Kraut, Joshua; Brasil, Connie; Wu, Minghong, G.

    2015-01-01

    This paper describes the background, method and results of the Arrival Metering Precision Study (AMPS) conducted in the Airspace Operations Laboratory at NASA Ames Research Center in May 2014. The simulation study measured delivery accuracy, flight efficiency, controller workload, and acceptability of time-based metering operations to a meter fix at the terminal area boundary for different resolution levels of metering delay times displayed to the air traffic controllers and different levels of airspeed information made available to the Time-Based Flow Management (TBFM) system computing the delay. The results show that the resolution of the delay countdown timer (DCT) on the controllers display has a significant impact on the delivery accuracy at the meter fix. Using the 10 seconds rounded and 1 minute rounded DCT resolutions resulted in more accurate delivery than 1 minute truncated and were preferred by the controllers. Using the speeds the controllers entered into the fourth line of the data tag to update the delay computation in TBFM in high and low altitude sectors increased air traffic control efficiency and reduced fuel burn for arriving aircraft during time based metering.

  7. Electrosurgery with cellular precision.

    PubMed

    Palanker, Daniel V; Vankov, Alexander; Huie, Philip

    2008-02-01

    Electrosurgery, one of the most-often used surgical tools, is a robust but somewhat crude technology that has changed surprisingly little since its invention almost a century ago. Continuous radiofrequency is still used for tissue cutting, with thermal damage extending to hundreds of micrometers. In contrast, lasers developed 70 years later, have been constantly perfected, and the laser-tissue interactions explored in great detail, which has allowed tissue ablation with cellular precision in many laser applications. We discuss mechanisms of tissue damage by electric field, and demonstrate that electrosurgery with properly optimized waveforms and microelectrodes can rival many advanced lasers. Pulsed electric waveforms with burst durations ranging from 10 to 100 micros applied via insulated planar electrodes with 12 microm wide exposed edges produced plasma-mediated dissection of tissues with the collateral damage zone ranging from 2 to 10 microm. Length of the electrodes can vary from micrometers to centimeters and all types of soft tissues-from membranes to cartilage and skin could be dissected in liquid medium and in a dry field. This technology may allow for major improvements in outcomes of the current surgical procedures and development of much more refined surgical techniques. PMID:18270030

  8. Ischemic preconditioning enhances integrity of coronary endothelial tight junctions

    SciTech Connect

    Li, Zhao; Jin, Zhu-Qiu

    2012-08-31

    Highlights: Black-Right-Pointing-Pointer Cardiac tight junctions are present between coronary endothelial cells. Black-Right-Pointing-Pointer Ischemic preconditioning preserves the structural and functional integrity of tight junctions. Black-Right-Pointing-Pointer Myocardial edema is prevented in hearts subjected to ischemic preconditioning. Black-Right-Pointing-Pointer Ischemic preconditioning enhances translocation of ZO-2 from cytosol to cytoskeleton. -- Abstract: Ischemic preconditioning (IPC) is one of the most effective procedures known to protect hearts against ischemia/reperfusion (IR) injury. Tight junction (TJ) barriers occur between coronary endothelial cells. TJs provide barrier function to maintain the homeostasis of the inner environment of tissues. However, the effect of IPC on the structure and function of cardiac TJs remains unknown. We tested the hypothesis that myocardial IR injury ruptures the structure of TJs and impairs endothelial permeability whereas IPC preserves the structural and functional integrity of TJs in the blood-heart barrier. Langendorff hearts from C57BL/6J mice were prepared and perfused with Krebs-Henseleit buffer. Cardiac function, creatine kinase release, and myocardial edema were measured. Cardiac TJ function was evaluated by measuring Evans blue-conjugated albumin (EBA) content in the extravascular compartment of hearts. Expression and translocation of zonula occludens (ZO)-2 in IR and IPC hearts were detected with Western blot. A subset of hearts was processed for the observation of ultra-structure of cardiac TJs with transmission electron microscopy. There were clear TJs between coronary endothelial cells of mouse hearts. IR caused the collapse of TJs whereas IPC sustained the structure of TJs. IR increased extravascular EBA content in the heart and myocardial edema but decreased the expression of ZO-2 in the cytoskeleton. IPC maintained the structure of TJs. Cardiac EBA content and edema were reduced in IPC hearts. IPC

  9. Field Validation of ICF Residential Building Air-Tightness

    SciTech Connect

    Sacs, I.; Ternes, M.P.

    2001-01-01

    Recent advances in home construction methods have made considerable progress in addressing energy savings issues. Certain methods are potentially capable of tightening the building envelope, consequently reducing air leakage and minimizing heating and air conditioning related energy losses. Insulated concrete form (ICF) is an economically viable alternative to traditional woodframe construction. Two homes, one of wood-frame, the other of ICF construction, were studied. Standard air leakage testing procedures were used to compare air tightness characteristics achieved by the two construction types. The ICF home showed consistently lower values for air leakage in these tests. The buildings otherwise provided similar data during testing, suggesting that the difference in values is due to greater airtight integrity of the ICF construction method. Testing on more homes is necessary to be conclusive. However, ICF construction shows promise as a tighter building envelope construction method.

  10. Many-body tight-binding model for aluminum nanoparticles

    SciTech Connect

    Staszewska, Grazyna; Staszewski, Przemyslaw; Schultz, Nathan E.; Truhlar, Donald G.

    2005-01-15

    A new, parametrized many-body tight-binding model is proposed for calculating the potential energy surface for aluminum nanoparticles. The parameters have been fitted to reproduce the energies for a variety of aluminum clusters (Al{sub 2}, Al{sub 3}, Al{sub 4}, Al{sub 7}, Al{sub 13}) calculated recently by the PBE0/MG3 method as well as the experimental face-centered-cubic cohesive energy, lattice constant, and a small set of Al cluster ionization potentials. Several types of parametrization are presented and compared. The mean unsigned error per atom for the best model is less than 0.03 eV.

  11. Universal Sign Control of Coupling in Tight-Binding Lattices.

    PubMed

    Keil, Robert; Poli, Charles; Heinrich, Matthias; Arkinstall, Jake; Weihs, Gregor; Schomerus, Henning; Szameit, Alexander

    2016-05-27

    We present a method of locally inverting the sign of the coupling term in tight-binding systems, by means of inserting a judiciously designed ancillary site and eigenmode matching of the resulting vertex triplet. Our technique can be universally applied to all lattice configurations, as long as the individual sites can be detuned. We experimentally verify this method in laser-written photonic lattices and confirm both the magnitude and the sign of the coupling by interferometric measurements. Based on these findings, we demonstrate how such universal sign-flipped coupling links can be embedded into extended lattice structures to impose a Z_{2}-gauge transformation. This opens a new avenue for investigations on topological effects arising from magnetic fields with aperiodic flux patterns or in disordered systems. PMID:27284657

  12. Multiporosity Flow of Gases in Tight Shale Formations

    NASA Astrophysics Data System (ADS)

    Kuhlman, K. L.; Heath, J. E.; Gardner, P.; Robinson, D. G.

    2014-12-01

    Flow and transport in low-permeability fractured systems is important in both groundwater applications and low-permeability hydrocarbon systems. We have adapted the multirate solute transport model to the flow of single-phase natural tracers in low-permeability hydrocarbon source rocks, termed the multiporosity model. We illustrate the ability of the multiporosity model to generalize double-porosity models, of both the pseudo-steady (e.g., Warren and Root) and transient (Kazemi) interporosity flow types. We use the model to explore both production (pressure and flowrate) and compositional data obtained from tight gas shale formations using a Baeysian uncertainty quantification approach.Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000.

  13. Crude oil prices: Are our oil markets too tight?

    SciTech Connect

    Simmons, M.R.

    1997-02-01

    The answer to the question posed in the title is that tightness in the market will surely prevail through 1997. And as discussed herein, with worldwide demand expected to continue to grow, there will be a strong call on extra oil supply. Meeting those demands, however, will not be straightforward--as many observers wrongly believe--considering the industry`s practice of maintaining crude stocks at ``Just in time`` inventory levels. Further, impact will be felt from the growing rig shortage, particularly for deepwater units, and down-stream capacity limits. While these factors indicate 1997 should be another good year for the service industry, it is difficult to get any kind of consensus view from the oil price market. With most observers` information dominated by the rarely optimistic futures price of crude, as reflected by the NYMEX, the important fact is that oil prices have remained stable for three years and increased steadily through 1996.

  14. Efficient self-consistency for magnetic tight binding

    NASA Astrophysics Data System (ADS)

    Soin, Preetma; Horsfield, A. P.; Nguyen-Manh, D.

    2011-06-01

    Tight binding can be extended to magnetic systems by including an exchange interaction on an atomic site that favours net spin polarisation. We have used a published model, extended to include long-ranged Coulomb interactions, to study defects in iron. We have found that achieving self-consistency using conventional techniques was either unstable or very slow. By formulating the problem of achieving charge and spin self-consistency as a search for stationary points of a Harris-Foulkes functional, extended to include spin, we have derived a much more efficient scheme based on a Newton-Raphson procedure. We demonstrate the capabilities of our method by looking at vacancies and self-interstitials in iron. Self-consistency can indeed be achieved in a more efficient and stable manner, but care needs to be taken to manage this. The algorithm is implemented in the code PLATO. Program summaryProgram title:PLATO Catalogue identifier: AEFC_v2_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEFC_v2_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 228 747 No. of bytes in distributed program, including test data, etc.: 1 880 369 Distribution format: tar.gz Programming language: C and PERL Computer: Apple Macintosh, PC, Unix machines Operating system: Unix, Linux, Mac OS X, Windows XP Has the code been vectorised or parallelised?: Yes. Up to 256 processors tested RAM: Up to 2 Gbytes per processor Classification: 7.3 External routines: LAPACK, BLAS and optionally ScaLAPACK, BLACS, PBLAS, FFTW Catalogue identifier of previous version: AEFC_v1_0 Journal reference of previous version: Comput. Phys. Comm. 180 (2009) 2616 Does the new version supersede the previous version?: Yes Nature of problem: Achieving charge and spin self-consistency in magnetic tight binding can be very

  15. Quantifying tight-gas sandstone permeability via critical path analysis

    NASA Astrophysics Data System (ADS)

    Ghanbarian, Behzad; Torres-Verdín, Carlos; Skaggs, Todd H.

    2016-06-01

    Rock permeability has been actively investigated over the past several decades by the geosciences community. However, its accurate estimation still presents significant technical challenges, particularly in spatially complex rocks. In this short communication, we apply critical path analysis (CPA) to estimate permeability in porous rocks from measured mercury intrusion porosimetry and electrical conductivity data. Theoretical estimations of various CPA-based models are then compared to experimental measurements using eighteen tight-gas sandstones. Except for two of the samples, we find permeability estimations performed with the Skaggs model (assuming pore diameter independent of its length) more accurate than other models, within a factor of two of the measured permeabilities. We discuss some plausible sources of the uncertainties.

  16. Tight-binding approach to penta-graphene

    PubMed Central

    Stauber, T.; Beltrán, J. I.; Schliemann, J.

    2016-01-01

    We introduce an effective tight-binding model to discuss penta-graphene and present an analytical solution. This model only involves the π-orbitals of the sp2-hybridized carbon atoms and reproduces the two highest valence bands. By introducing energy-dependent hopping elements, originating from the elimination of the sp3-hybridized carbon atoms, also the two lowest conduction bands can be well approximated - but only after the inclusion of a Hubbard onsite interaction as well as of assisted hopping terms. The eigenfunctions can be approximated analytically for the effective model without energy-dependent hopping elements and the optical absorption is discussed. We find large isotropic absorption ranging from 7.5% up to 24% for transitions at the Γ-point. PMID:26940279

  17. Tight-binding lattices with an oscillating imaginary gauge field

    NASA Astrophysics Data System (ADS)

    Longhi, Stefano

    2016-08-01

    We consider non-Hermitian dynamics of a quantum particle hopping on a one-dimensional tight-binding lattice made of N sites with asymmetric hopping rates induced by a time-periodic oscillating imaginary gauge field. A deeply different behavior is found depending on the lattice topology. While in a linear chain (open boundary conditions) an oscillating field can lead to a complex quasienergy spectrum via a multiple parametric resonance; in a ring topology (Born-von Karman periodic boundary conditions) an entirely real quasienergy spectrum can be found and the dynamics is pseudo-Hermitian. In the large-N limit, parametric instability and pseudo-Hermitian dynamics in the two different lattice topologies are physically explained on the basis of a simple picture of wave-packet propagation.

  18. S0 Tight Loop Studies on ICHIRO 9-Cell Cavities

    SciTech Connect

    Furuta, Fumio; Konomi, T.; Saito, Kenji; Bice, Damon; Crawford, Anthony C.; Geng, Rongli

    2009-11-01

    We have continued high gradient R&D of ICHIRO 9-cell cavities at KEK. ICHIRO 9-cell cavity #5 (I9#5) that has no end groups on beam tube to focus on high gradient sent to Jlab as S0 tight loop study. Surface treatments and vertical test were repeated 3 times at Jlab, and then I9#5 sent back to KEK. We also repeated surface treatments and test at KEK. Maximum gradients were 36.5MV/m at Jlab, and 33.7MV/m at KEK so far. Now we are struggling with the puzzle why the results of singles do not work well on 9-cell cavities.

  19. Detection of Tight Junction Barrier Function In Vivo by Biotin

    PubMed Central

    Ding, Lei; Zhang, Yuguo; Tatum, Rodney; Chen, Yan-Hua

    2011-01-01

    Tight junctions (TJs) are the most apical component of the junctional complexes in mammalian epithelial cells and form selective paracellular barriers restricting the passage of solutes and ions across the epithelial sheets. Claudins, a TJ integral membrane protein family, play a critical role in regulating paracellular barrier permeability. In the in vitro cell culture system, transepithelial electrical resistance (TER) measurement and the flux of radioisotope or fluorescent labeled molecules with different sizes have been widely used to determine the TJ barrier function. In the in vivo system, the tracer molecule Sulfo-NHS-Biotin was initially used in Xenopus embryos system and subsequently was successfully applied to a number of animal tissues in situ and in different organisms under the experimental conditions to examine the functional integrity of TJs by several laboratories. In this chapter, we will describe the detailed procedures of applying biotin as a paracellular tracer molecule to different in vivo systems to assay TJ barrier function. PMID:21717351

  20. Universal Sign Control of Coupling in Tight-Binding Lattices

    NASA Astrophysics Data System (ADS)

    Keil, Robert; Poli, Charles; Heinrich, Matthias; Arkinstall, Jake; Weihs, Gregor; Schomerus, Henning; Szameit, Alexander

    2016-05-01

    We present a method of locally inverting the sign of the coupling term in tight-binding systems, by means of inserting a judiciously designed ancillary site and eigenmode matching of the resulting vertex triplet. Our technique can be universally applied to all lattice configurations, as long as the individual sites can be detuned. We experimentally verify this method in laser-written photonic lattices and confirm both the magnitude and the sign of the coupling by interferometric measurements. Based on these findings, we demonstrate how such universal sign-flipped coupling links can be embedded into extended lattice structures to impose a Z2-gauge transformation. This opens a new avenue for investigations on topological effects arising from magnetic fields with aperiodic flux patterns or in disordered systems.

  1. Methods and apparatus for measuring the tightness of enclosures

    DOEpatents

    Modera, Mark P.; Sherman, Max H.

    1987-01-13

    Disclosed are methods and apparatus for measuring tightness of an enclosure such as a building by utilizing alternating pressurization techniques. One method comprises providing apparatus capable of causing an internal volume change for the enclosure, the apparatus including a means for determining the instantaneous volume change, and a means for determining the instantaneous pressure within the enclosure. The apparatus is operated within the enclosure to change the volume thereof, and at least one of the frequency and the displacement is adjusted to achieve a root mean square pressure in the enclosure approximately equal to a reference pressure. At that pressure, the leakage of the enclosure is determined from the instantaneous displacement and instantaneous pressure values.

  2. Qutrit Magic State Distillation Tight in Some Directions

    NASA Astrophysics Data System (ADS)

    Dawkins, Hillary; Howard, Mark

    2015-07-01

    Magic state distillation is a crucial component in the leading approaches to implementing universal fault-tolerant quantum computation, with existing protocols for both qubit and higher dimensional systems. Early work focused on determining the region of distillable states for qubit protocols; yet comparatively little is known about which states can be distilled and with what distillable region for d >2 . Here we focus on d =3 and present new four-qutrit distillation schemes that improve upon the known distillable region, and achieve distillation tight to the boundary of undistillable states for some classes of state. As a consequence of recent results, this implies that there is a family of quantum states that enable universality if and only if they exhibit contextuality with respect to stabilizer measurements. We also identify a new routine whose fixed point is a magic state with maximal sum negativity; i.e., it is maximally nonstablizer in a specific sense.

  3. Tight-binding approach to penta-graphene

    NASA Astrophysics Data System (ADS)

    Stauber, T.; Beltrán, J. I.; Schliemann, J.

    2016-03-01

    We introduce an effective tight-binding model to discuss penta-graphene and present an analytical solution. This model only involves the π-orbitals of the sp2-hybridized carbon atoms and reproduces the two highest valence bands. By introducing energy-dependent hopping elements, originating from the elimination of the sp3-hybridized carbon atoms, also the two lowest conduction bands can be well approximated - but only after the inclusion of a Hubbard onsite interaction as well as of assisted hopping terms. The eigenfunctions can be approximated analytically for the effective model without energy-dependent hopping elements and the optical absorption is discussed. We find large isotropic absorption ranging from 7.5% up to 24% for transitions at the Γ-point.

  4. Tightly Coupled Multiphysics Algorithm for Pebble Bed Reactors

    SciTech Connect

    HyeongKae Park; Dana Knoll; Derek Gaston; Richard Martineau

    2010-10-01

    We have developed a tightly coupled multiphysics simulation tool for the pebble-bed reactor (PBR) concept, a type of Very High-Temperature gas-cooled Reactor (VHTR). The simulation tool, PRONGHORN, takes advantages of the Multiphysics Object-Oriented Simulation Environment library, and is capable of solving multidimensional thermal-fluid and neutronics problems implicitly with a Newton-based approach. Expensive Jacobian matrix formation is alleviated via the Jacobian-free Newton-Krylov method, and physics-based preconditioning is applied to minimize Krylov iterations. Motivation for the work is provided via analysis and numerical experiments on simpler multiphysics reactor models. We then provide detail of the physical models and numerical methods in PRONGHORN. Finally, PRONGHORN's algorithmic capability is demonstrated on a number of PBR test cases.

  5. Methods and apparatus for measuring the tightness of enclosures

    DOEpatents

    Modera, M.P.; Sherman, M.H.

    1987-01-13

    Disclosed are methods and apparatus for measuring tightness of an enclosure such as a building by utilizing alternating pressurization techniques. One method comprises providing apparatus capable of causing an internal volume change for the enclosure, the apparatus including a means for determining the instantaneous volume change, and a means for determining the instantaneous pressure within the enclosure. The apparatus is operated within the enclosure to change the volume thereof, and at least one of the frequency and the displacement is adjusted to achieve a root mean square pressure in the enclosure approximately equal to a reference pressure. At that pressure, the leakage of the enclosure is determined from the instantaneous displacement and instantaneous pressure values. 3 figs.

  6. Remarks on the tight-binding model of graphene

    NASA Astrophysics Data System (ADS)

    Bena, Cristina; Montambaux, Gilles

    2009-09-01

    We address a simple but fundamental issue arising in the study of graphene, as well as of other systems that have a crystalline structure with more than one atom per unit cell. For these systems, the choice of the tight-binding basis is not unique. For monolayer graphene two bases are widely used in the literature. While the expectation values of operators describing physical quantities should be independent of basis, the form of the operators may depend on the basis, especially in the presence of disorder or of an applied magnetic field. Using an inappropriate form of certain operators may lead to erroneous physical predictions. We discuss the two bases used to describe monolayer graphene, as well as the form of the most commonly used operators in the two bases. We repeat our analysis for the case of bilayer graphene.

  7. Quantum Physics Inspired Optical Effects in Tight-Binding Lattices

    NASA Astrophysics Data System (ADS)

    Thompson, Clinton; Vemuri, Gautam

    We theoretically investigated the propagation of light inside an array of single-mode evanescently coupled waveguides that can be described by the tight-binding Hamiltonian. We show that directed photonic transport can be achieved with phase-displaced inputs. In addition, the form of a parity-symmetric waveguide-dependent coupling constant can tune the dynamics of the photon's wavepacket. Lastly, we examine the statistical aspects of the output light for different input fields when disorder is present in the waveguide array. We find that the light will undergo Anderson localization independent of the type of field and that the intensity fluctuations of the output light will increase with disorder at the initial waveguide.

  8. Elemental and tight monogamy relations in nonsignaling theories

    NASA Astrophysics Data System (ADS)

    Augusiak, R.; Demianowicz, M.; Pawłowski, M.; Tura, J.; Acín, A.

    2014-11-01

    Physical principles constrain the way nonlocal correlations can be distributed among distant parties. These constraints are usually expressed by monogamy relations that bound the amount of Bell inequality violation observed among a set of parties by the violation observed by a different set of parties. We prove here that much stronger monogamy relations are possible for nonsignaling correlations by showing how nonlocal correlations among a set of parties limit any form of correlations, not necessarily nonlocal, shared among other parties. In particular, we provide tight bounds between the violation of a family of Bell inequalities among an arbitrary number of parties and the knowledge an external observer can gain about outcomes of any single measurement performed by the parties. Finally, we show how the obtained monogamy relations offer an improvement over the existing protocols for device-independent quantum key distribution and randomness amplification.

  9. Bacteria-tight sealing of exposed dog pulps.

    PubMed

    Wijnbergen-Buijen van Weelderen, M; van Mullem, P J

    1984-05-01

    Penetration of bacteria past filling materials can interfere with the vitality of exposed pulps. In the present study, seventy-three dog's teeth were filled--after exposure--with Cavit -W and then sealed either with a chemically or a UV polymerizing bonding. After 14 days a failure rate of 28% was demonstrated using the chemically polymerizing Concise and of 4.5% using the UV polymerizing Uvio -Bond. After 42 days the latter bonding revealed a success rate of 100%. To achieve a bacteria-tight seal of deep cavities for middle long term animal experimentation, Uvio -Bond can be used--after etching--to cover the filling material and the surrounding enamel. PMID:6234386

  10. Tight-binding study of bilayer graphene Josephson junctions

    NASA Astrophysics Data System (ADS)

    Muñoz, W. A.; Covaci, L.; Peeters, F. M.

    2012-11-01

    Using highly efficient simulations of the tight-binding Bogoliubov-de-Gennes model, we solved self-consistently for the pair correlation and the Josephson current in a superconducting-bilayer graphene-superconducting Josephson junction. Different doping levels for the non-superconducting link are considered in the short- and long-junction regimes. Self-consistent results for the pair correlation and superconducting current resemble those reported previously for single-layer graphene except at the Dirac point, where remarkable differences in the proximity effect are found, as well as a suppression of the superconducting current in the long-junction regime. Inversion symmetry is broken by considering a potential difference between the layers and we found that the supercurrent can be switched if the junction length is larger than the Fermi length.

  11. Quasi-symmetric designs and equiangular tight frames

    NASA Astrophysics Data System (ADS)

    Fickus, Matthew; Jasper, John; Mixon, Dustin; Peterson, Jesse

    2015-08-01

    An equiangular tight frame (ETF) is an M×N matrix which has orthogonal equal norm rows, equal norm columns, and the inner products of all pairs of columns have the same modulus. ETFs arise in numerous applications, including compressed sensing. They also seem to be rare: despite over a decade of active research by the community, only a few construction methods have been discovered. In this article we introduce a new construction of ETFs which uses a particular set of combinatorial designs called quasi-symmetric designs. For ETFs whose entries are contained in {+1;-1}, called real constant amplitude ETFs (RCAETFs), we see that this construction is reversible, giving new quasi-symmetric designs from the known constructions RCAETFs.

  12. Precise Truss Assembly using Commodity Parts and Low Precision Welding

    NASA Technical Reports Server (NTRS)

    Komendera, Erik; Reishus, Dustin; Dorsey, John T.; Doggett, William R.; Correll, Nikolaus

    2013-01-01

    We describe an Intelligent Precision Jigging Robot (IPJR), which allows high precision assembly of commodity parts with low-precision bonding. We present preliminary experiments in 2D that are motivated by the problem of assembling a space telescope optical bench on orbit using inexpensive, stock hardware and low-precision welding. An IPJR is a robot that acts as the precise "jigging", holding parts of a local assembly site in place while an external low precision assembly agent cuts and welds members. The prototype presented in this paper allows an assembly agent (in this case, a human using only low precision tools), to assemble a 2D truss made of wooden dowels to a precision on the order of millimeters over a span on the order of meters. We report the challenges of designing the IPJR hardware and software, analyze the error in assembly, document the test results over several experiments including a large-scale ring structure, and describe future work to implement the IPJR in 3D and with micron precision.

  13. Precision medicine in myasthenia graves: begin from the data precision

    PubMed Central

    Hong, Yu; Xie, Yanchen; Hao, Hong-Jun; Sun, Ren-Cheng

    2016-01-01

    Myasthenia gravis (MG) is a prototypic autoimmune disease with overt clinical and immunological heterogeneity. The data of MG is far from individually precise now, partially due to the rarity and heterogeneity of this disease. In this review, we provide the basic insights of MG data precision, including onset age, presenting symptoms, generalization, thymus status, pathogenic autoantibodies, muscle involvement, severity and response to treatment based on references and our previous studies. Subgroups and quantitative traits of MG are discussed in the sense of data precision. The role of disease registries and scientific bases of precise analysis are also discussed to ensure better collection and analysis of MG data. PMID:27127759

  14. Precise Truss Assembly Using Commodity Parts and Low Precision Welding

    NASA Technical Reports Server (NTRS)

    Komendera, Erik; Reishus, Dustin; Dorsey, John T.; Doggett, W. R.; Correll, Nikolaus

    2014-01-01

    Hardware and software design and system integration for an intelligent precision jigging robot (IPJR), which allows high precision assembly using commodity parts and low-precision bonding, is described. Preliminary 2D experiments that are motivated by the problem of assembling space telescope optical benches and very large manipulators on orbit using inexpensive, stock hardware and low-precision welding are also described. An IPJR is a robot that acts as the precise "jigging", holding parts of a local structure assembly site in place, while an external low precision assembly agent cuts and welds members. The prototype presented in this paper allows an assembly agent (for this prototype, a human using only low precision tools), to assemble a 2D truss made of wooden dowels to a precision on the order of millimeters over a span on the order of meters. The analysis of the assembly error and the results of building a square structure and a ring structure are discussed. Options for future work, to extend the IPJR paradigm to building in 3D structures at micron precision are also summarized.

  15. Experiments on Exhaust Noise of Tightly Integrated Propulsion Systems

    NASA Technical Reports Server (NTRS)

    Bridges, James E.; Brown, Clifford A.; Bozak, Richard F.

    2014-01-01

    A wide-ranging series of tests have been completed that seek to map the effects of installation, including jet by jet interaction effects, on exhaust noise from various nozzles in forward flight. The primary data was far-field acoustic spectral directivity. The goals of the test series were (i) to generate enough data for empirical models of the different effects, and (ii) to provide data for advanced computational noise predictions methods applied to simplified yet realistic configurations. Data is presented that demonstrate several checks on data quality and that provide an overview of trends observed to date. Among the findings presented here: (i) Data was repeatable between jet rigs for single nozzles with and without surfaces to within +/- 0.5 dB. (ii) The presence of a second jet caused a strong reduction of the summed noise in the plane of the two plumes and an increase over the expected source doubling in most other azimuthal planes. (iii) The impact of the second jet was reduced when the jets were unheated. (iv) The impact of adding a second isolated rectangular jet was relatively independent of the nozzle aspect ratio up to aspect ratio 8:1. (v) Forward flight had similar impact on a high aspect ratio (8:1) jet as on an axisymmetric jet, except at the peak noise angle where the impact was less. (vi) The effect of adding a second round jet to a tightly integrated nozzle where the nozzle lip was less than a diameter from the surface was very dependent upon the length of the surface downstream of the nozzle. (vii) When the nozzles were rectangular and tightly integrated with the airframe surface the impact of a second jet was very dependent upon how close together the two jets were. This paper serves as an overview of the test; other papers presented in the same conference will give more detailed analysis of the results.

  16. Contrasting evolutionary histories among tightly linked HLA loci.

    PubMed Central

    Klitz, W; Thomson, G; Baur, M P

    1986-01-01

    Genes comprising the major histocompatibility complex (MHC) play a central role in governing the immune response of vertebrates. A great deal of information has been revealed on the molecular biology and physiology of these loci, but three features-the high polymorphism, tight linkage among the loci, and the nonrandom association of alleles-make the system of particular interest from the perspective of population genetics. Information on the dynamic evolutionary forces that have acted on a locus can be inferred from the number and distribution of alleles that it carries. Ten loci from the HLA region of the human MHC, each sampled from several different populations, have been examined for departures from the expected value of homozygosity under the condition of selective neutrality. The homozygosities of five class I and II loci that code for membrane glycoproteins, HLA-A, -B, -C, -DR, and -DQ, and of glyoxylase I (GLO) were significantly less than the neutrality expectations. This suggests the presence of some form of balancing selection. In spite of being closely linked, in fact, located between the class I and class II histocompatibility loci, the homozygosities of the four class III or complement loci C2, Bf, C4A, and C4B, which are detected by electrophoresis, were indistinguishable from, or exceeded, that expected under neutrality. Although this conforms to the suggestion that, in general, electrophoretic variants are neutral, because of the tight linkage to loci demonstrating a history of selection, it is possible that the mechanism for generating variation in the class III loci may be different from that of the class I and class II loci. PMID:3766540

  17. Disruptive advancement in precision lens mounting

    NASA Astrophysics Data System (ADS)

    Lamontagne, Frédéric; Desnoyers, Nichola; Doucet, Michel; Côté, Patrice; Gauvin, Jonny; Anctil, Geneviève

    2015-09-01

    Threaded rings are used to fix lenses in a large portion of opto-mechanical assemblies. This is the case for the low cost drop-in approach in which the lenses are dropped into cavities cut into a barrel and clamped with threaded rings. The walls of a cavity are generally used to constrain the lateral and axial position of the lens within the cavity. In general, the drop-in approach is low cost but imposes fundamental limitations especially on the optical performances. On the other hand, active alignment methods provide a high level of centering accuracy but increase the cost of the optical assembly. This paper first presents a review of the most common lens mounting techniques used to secure and center lenses in optical systems. Advantages and disadvantages of each mounting technique are discussed in terms of precision and cost. Then, the different contributors which affect the centering of a lens when using the drop-in approach, such as the threaded ring, friction, and manufacturing errors, are detailed. Finally, a patent pending lens mounting technique developed at INO that alleviates the drawbacks of the drop-in and the active alignment approaches is introduced. This innovative auto-centering method requires a very low assembly time, does not need tight manufacturing tolerances and offers a very high level of centering accuracy, usually less than 5 μm. Centering test results performed on real optical assemblies are also presented.

  18. Precision Cryogenic Dilatometer

    NASA Technical Reports Server (NTRS)

    Dudik, Matthew; Halverson, Peter; Levine-West, Marie; Marcin, Martin; Peters, Robert D.; Shaklan, Stuart

    2005-01-01

    A dilatometer based on a laser interferometer is being developed to measure mechanical creep and coefficients of thermal expansion (CTEs) of materials at temperatures ranging from ambient down to 15 K. This cryogenic dilatometer has been designed to minimize systematic errors that limit the best previously available dilatometers. At its prototype stage of development, this cryogenic dilatometer yields a strain measurement error of 35 ppb or 1.7 ppb/K CTE measurement error for a 20-K thermal load, for low-expansion materials in the temperature range from 310 down to 30 K. Planned further design refinements that include a provision for stabilization of the laser and addition of a high-precision sample-holding jig are expected to reduce the measurement error to 5-ppb strain error or 0.3-ppb/K CTE error for a 20-K thermal load. The dilatometer (see figure) includes a common-path, differential, heterodyne interferometer; a dual-frequency, stabilized source bench that serves as the light source for the interferometer; a cryogenic chamber in which one places the material sample to be studied; a cryogenic system for cooling the interior of the chamber to the measurement temperature; an ultra-stable alignment stage for positioning the chamber so that the sample is properly positioned with respect to the interferometer; and a data-acquisition and control system. The cryogenic chamber and the interferometer portion of the dilatometer are housed in a vacuum chamber on top of a vibration isolating optical table in a cleanroom. The sample consists of two pieces a pillar on a base both made of the same material. Using reflections of the interferometer beams from the base and the top of the pillar, what is measured is the change in length of the pillar as the temperature in the chamber is changed. In their fundamental optical and electronic principles of operation, the laser light source and the interferometer are similar to those described in Common-Path Heterodyne

  19. Centroid precision and orientation precision of planar localization microscopy.

    PubMed

    McGray, C; Copeland, C R; Stavis, S M; Geist, J

    2016-09-01

    The concept of localization precision, which is essential to localization microscopy, is formally extended from optical point sources to microscopic rigid bodies. Measurement functions are presented to calculate the planar pose and motion of microscopic rigid bodies from localization microscopy data. Physical lower bounds on the associated uncertainties - termed centroid precision and orientation precision - are derived analytically in terms of the characteristics of the optical measurement system and validated numerically by Monte Carlo simulations. The practical utility of these expressions is demonstrated experimentally by an analysis of the motion of a microelectromechanical goniometer indicated by a sparse constellation of fluorescent nanoparticles. Centroid precision and orientation precision, as developed here, are useful concepts due to the generality of the expressions and the widespread interest in localization microscopy for super-resolution imaging and particle tracking. PMID:26970565

  20. PRECISION FARMING FOR NITROGEN MANAGEMENT

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Approaches to precision nitrogen management vary from region to region depending on crop, soils, landscape, and climate yet all strategies essentially attempt to estimate crop nitrogen demand or plant available nitrogen. In this chapter, we provide case studies that illustrate precision nitrogen ma...

  1. Precise-Conductance Valve Insert

    NASA Technical Reports Server (NTRS)

    Outlaw, R. A.; Hoyt, R. F.

    1986-01-01

    Valve modification provides two operating modes fully open and small, precise leak. Copper insert with radially oriented holes allows small, controllable, precise effusion rate when valve closed or nearly unobstructed flow when valve open. Numerous applications in surface physics, vacuum physics, materials science, gas kinetics, thin films, and other areas of research requiring measured flows of gas into or out of system.

  2. MEASUREMENT AND PRECISION, EXPERIMENTAL VERSION.

    ERIC Educational Resources Information Center

    Harvard Univ., Cambridge, MA. Harvard Project Physics.

    THIS DOCUMENT IS AN EXPERIMENTAL VERSION OF A PROGRAMED TEXT ON MEASUREMENT AND PRECISION. PART I CONTAINS 24 FRAMES DEALING WITH PRECISION AND SIGNIFICANT FIGURES ENCOUNTERED IN VARIOUS MATHEMATICAL COMPUTATIONS AND MEASUREMENTS. PART II BEGINS WITH A BRIEF SECTION ON EXPERIMENTAL DATA, COVERING SUCH POINTS AS (1) ESTABLISHING THE ZERO POINT, (2)…

  3. Tight, Flat, Smooth, Ultrathin Metal Foils for Locating Synchrotron Beams

    NASA Astrophysics Data System (ADS)

    Jolivet, Connie S.; Stoner, John O.

    2007-01-01

    It is often desired to locate a synchrotron x-ray beam precisely in space with minimal disturbance of its spatial profile and spectral content. This can be done by passing the beam through an ultrathin, flat, smooth metal foil having well-defined composition, preferably a single chemical element such as chromium, titanium or aluminum. Localized fluorescence of the foil at characteristic x-ray lines where the x-ray beam passes through the foil serves to locate the beam in two dimensions. Use of two such foils along the beam direction locates the x-ray beam spatially and identifies precisely its direction. The accuracy of determining these parameters depends in part upon high uniformity in the thickness of the foil(s), good planarity, and smoothness of the foil(s). In practice, several manufacturing steps to produce a foil must be carried out with precision. The foil must be produced on a smooth removable substrate in such a way that its thickness (or areal density) is as uniform as possible. The foil must be fastened to a support ring that maintains the foil's surface quality, and it must be then stretched onto a frame that produces the desired mirror flatness. These steps are illustrated and some of the parameters specifying the quality of the resulting foils are identified.

  4. Strengthening of the intestinal epithelial tight junction by Bifidobacterium bifidum

    PubMed Central

    Hsieh, Chen-Yu; Osaka, Toshifumi; Moriyama, Eri; Date, Yasuhiro; Kikuchi, Jun; Tsuneda, Satoshi

    2015-01-01

    Epithelial barrier dysfunction has been implicated as one of the major contributors to the pathogenesis of inflammatory bowel disease. The increase in intestinal permeability allows the translocation of luminal antigens across the intestinal epithelium, leading to the exacerbation of colitis. Thus, therapies targeted at specifically restoring tight junction barrier function are thought to have great potential as an alternative or supplement to immunology-based therapies. In this study, we screened Bifidobacterium, Enterococcus, and Lactobacillus species for beneficial microbes to strengthen the intestinal epithelial barrier, using the human intestinal epithelial cell line (Caco-2) in an in vitro assay. Some Bifidobacterium and Lactobacillus species prevented epithelial barrier disruption induced by TNF-α, as assessed by measuring the transepithelial electrical resistance (TER). Furthermore, live Bifidobacterium species promoted wound repair in Caco-2 cell monolayers treated with TNF-α for 48 h. Time course 1H-NMR-based metabonomics of the culture supernatant revealed markedly enhanced production of acetate after 12 hours of coincubation of B. bifidum and Caco-2. An increase in TER was observed by the administration of acetate to TNF-α-treated Caco-2 monolayers. Interestingly, acetate-induced TER-enhancing effect in the coculture of B. bifidum and Caco-2 cells depends on the differentiation stage of the intestinal epithelial cells. These results suggest that Bifidobacterium species enhance intestinal epithelial barrier function via metabolites such as acetate. PMID:25780093

  5. Tightly bound trions in monolayer MoS2

    NASA Astrophysics Data System (ADS)

    Mak, Kin Fai; He, Keliang; Lee, Changgu; Lee, Gwan Hyoung; Hone, James; Heinz, Tony F.; Shan, Jie

    2013-03-01

    Two-dimensional (2D) atomic crystals, such as graphene and transition-metal dichalcogenides, have emerged as a new class of materials with remarkable physical properties. In contrast to graphene, monolayer MoS2 is a non-centrosymmetric material with a direct energy gap. Strong photoluminescence, a current on/off ratio exceeding 108 in field-effect transistors, and efficient valley and spin control by optical helicity have recently been demonstrated in this material. Here we report the spectroscopic identification in a monolayer MoS2 field-effect transistor of tightly bound negative trions, a quasiparticle composed of two electrons and a hole. These quasiparticles, which can be optically created with valley and spin polarized holes, have no analogue in conventional semiconductors. They also possess a large binding energy (~ 20 meV), rendering them significant even at room temperature. Our results open up possibilities both for fundamental studies of many-body interactions and for optoelectronic and valleytronic applications in 2D atomic crystals.

  6. A tight-binding study of single-atom transistors.

    PubMed

    Ryu, Hoon; Lee, Sunhee; Fuechsle, Martin; Miwa, Jill A; Mahapatra, Suddhasatta; Hollenberg, Lloyd C L; Simmons, Michelle Y; Klimeck, Gerhard

    2015-01-21

    A detailed theoretical study of the electronic and transport properties of a single atom transistor, where a single phosphorus atom is embedded within a single crystal transistor architecture, is presented. Using a recently reported deterministic single-atom transistor as a reference, the electronic structure of the device is represented atomistically with a tight-binding model, and the channel modulation is simulated self-consistently with a Thomas-Fermi method. The multi-scale modeling approach used allows confirmation of the charging energy of the one-electron donor charge state and explains how the electrostatic environments of the device electrodes affects the donor confinement potential and hence extent in gate voltage of the two-electron charge state. Importantly, whilst devices are relatively insensitive to dopant ordering in the highly doped leads, a ∼1% variation of the charging energy is observed when a dopant is moved just one lattice spacing within the device. The multi-scale modeling method presented here lays a strong foundation for the understanding of single-atom device structures: essential for both classical and quantum information processing. PMID:25293353

  7. Paroxysmal dystonic choreoathetosis: Tight linkage to chromosome 2q

    SciTech Connect

    Fink, J.K.; Rainier, S.; Wilkowski, J.; Jones, S.M.

    1996-07-01

    Paroxysmal dystonic choreoathetosis (PDC) is characterized by attacks of involuntary movements that last up to several hours and occur at rest both spontaneously and following caffeine or alcohol consumption. We analyzed a Polish-American kindred with autosomal dominant PDC and identified tight linkage between the disorder and microsatellite markers on chromosome 2q (maximum two-point LOD score 4.77; recombination fraction 0). Our results clearly establish the existence of a locus for autosomal dominant PDC on distal chromosome 2q. The fact that three other paroxysmal neurological disorders (periodic ataxia with myokymia and hypo- and hyperkalemic periodic paralysis) are due to mutation in ion-channel genes raises the possibility that PDC is also due to an ion-channel gene mutation. It is noteworthy that a cluster of sodium-channel genes is located on distal chromosome 2q, near the PDC locus. Identifying the PDC locus on chromosome 2q will facilitate discovery whether PDC is genetically homogeneous and whether other paroxysmal movement disorders are also genetically linked to the PDC locus. 28 refs., 2 figs., 1 tab.

  8. Role of Microscopic Flexibility in Tightly Curved DNA

    PubMed Central

    2015-01-01

    The genetic material in living cells is organized into complex structures in which DNA is subjected to substantial contortions. Here we investigate the difference in structure, dynamics, and flexibility between two topological states of a short (107 base pair) DNA sequence in a linear form and a covalently closed, tightly curved circular DNA form. By employing a combination of all-atom molecular dynamics (MD) simulations and elastic rod modeling of DNA, which allows capturing microscopic details while monitoring the global dynamics, we demonstrate that in the highly curved regime the microscopic flexibility of the DNA drastically increases due to the local mobility of the duplex. By analyzing vibrational entropy and Lipari–Szabo NMR order parameters from the simulation data, we propose a novel model for the thermodynamic stability of high-curvature DNA states based on vibrational untightening of the duplex. This novel view of DNA bending provides a fundamental explanation that bridges the gap between classical models of DNA and experimental studies on DNA cyclization, which so far have been in substantial disagreement. PMID:25155114

  9. Prediction of Gas Leak Tightness of Superplastically Formed Products

    NASA Astrophysics Data System (ADS)

    Snippe, Corijn H. C.; Meinders, T.

    2010-06-01

    In some applications, in this case an aluminium box in a subatomic particle detector containing highly sensitive detecting devices, it is important that a formed sheet should show no gas leak from one side to the other. In order to prevent a trial-and-error procedure to make this leak tight box, a method is set up to predict if a formed sheet conforms to the maximum leak constraint. The technique of superplastic forming (SPF) is used in order to attain very high plastic strains before failure. Since only a few of these boxes are needed, this makes, this generally slow, process an attractive production method. To predict the gas leak of a superplastically formed aluminium sheet in an accurate way, finite element simulations are used in combination with a user-defined material model. This constitutive model couples the leak rate with the void volume fraction. This void volume fraction is then dependent on both the equivalent plastic strain and the applied hydrostatic pressure during the bulge process (backpressure).

  10. Analytical approach to atomic multichannel collisions in tight harmonic waveguides

    NASA Astrophysics Data System (ADS)

    Heß, Benjamin; Giannakeas, Panagiotis; Schmelcher, Peter

    2015-08-01

    We perform an analytical investigation in the framework of generalized K -matrix theory of the scattering problem in tight isotropic and harmonic waveguides allowing for several open scattering channels. The scattering behavior is explored for identical bosons and fermions, as well as for distinguishable particles, the main aspect being the confinement-induced resonances (CIR) which are attributed to different partial waves. In particular, we present the unitarity bounds which emerge when considering a quasi-one-dimensional system. Unitarity bounds are also given for the transition coefficients, which show the limitations for efficient transversal (de)excitations by means of CIRs. We analyze the CIR for d waves and find the intriguing phenomenon of a strong transmission suppression in the presence of more than one open channel, which represents an interesting regime to be applied in the corresponding many-particle systems. The corresponding channel threshold singularities are studied and it is shown that these are solely determined by the symmetry class of the partial wave.

  11. Emerging Multifunctional Roles of Claudin Tight Junction Proteins in Bone

    PubMed Central

    Alshbool, Fatima. Z.

    2014-01-01

    The imbalance between bone formation and resorption during bone remodeling has been documented to be a major factor in the pathogenesis of osteoporosis. Recent evidence suggests a significant role for the tight junction proteins, Claudins (Cldns), in the regulation of bone remodeling processes. In terms of function, whereas Cldns act “canonically” as key determinants of paracellular permeability, there is considerable recent evidence to suggest that Cldns also participate in cell signaling, ie, a “noncanonical function”. To this end, Cldns have been shown to regulate cell proliferation, differentiation, and gene expression in a variety of cell types. The present review will discuss Cldns' structure, their expression profile, regulation of expression, and their canonical and non- canonical functions in general with special emphasis on bone cells. In order to shed light on the noncanonical functions of Cldns in bone, we will highlight the role of Cldn-18 in regulating bone resorption and osteoclast differentiation. Collectively, we hope to provide a framework for guiding future research on understanding how Cldns modulate osteoblast and osteoclast function and overall bone homeostasis. Such studies should provide valuable insights into the pathogenesis of osteoporosis, and may highlight Cldns as novel targets for the diagnosis and therapeutic management of osteoporosis. PMID:24758302

  12. Phononic crystals of spherical particles: A tight binding approach

    SciTech Connect

    Mattarelli, M.; Secchi, M.; Dipartimento di Fisica, Università di Trento, Via Sommarive 14, 38123 Trento ; Montagna, M.

    2013-11-07

    The vibrational dynamics of a fcc phononic crystal of spheres is studied and compared with that of a single free sphere, modelled either by a continuous homogeneous medium or by a finite cluster of atoms. For weak interaction among the spheres, the vibrational dynamics of the phononic crystal is described by shallow bands, with low degree of dispersion, corresponding to the acoustic spheroidal and torsional modes of the single sphere. The phonon displacements are therefore related to the vibrations of a sphere, as the electron wave functions in a crystal are related to the atomic wave functions in a tight binding model. Important dispersion is found for the two lowest phonon bands, which correspond to zero frequency free translation and rotation of a free sphere. Brillouin scattering spectra are calculated at some values of the exchanged wavevectors of the light, and compared with those of a single sphere. With weak interaction between particles, given the high acoustic impedance mismatch in dry systems, the density of phonon states consist of sharp bands separated by large gaps, which can be well accounted for by a single particle model. Based on the width of the frequency gaps, tunable with the particle size, and on the small number of dispersive acoustic phonons, such systems may provide excellent materials for application as sound or heat filters.

  13. Environmental Public Health Dimensions of Shale and Tight Gas Development

    PubMed Central

    Hays, Jake; Finkel, Madelon L.

    2014-01-01

    Background: The United States has experienced a boom in natural gas production due to recent technological innovations that have enabled this resource to be produced from shale formations. Objectives: We reviewed the body of evidence related to exposure pathways in order to evaluate the potential environmental public health impacts of shale gas development. We highlight what is currently known and identify data gaps and research limitations by addressing matters of toxicity, exposure pathways, air quality, and water quality. Discussion: There is evidence of potential environmental public health risks associated with shale gas development. Several studies suggest that shale gas development contributes to ambient air concentrations of pollutants known to be associated with increased risk of morbidity and mortality. Similarly, an increasing body of studies suggest that water contamination risks exist through a variety of environmental pathways, most notably during wastewater transport and disposal, and via poor zonal isolation of gases and fluids due to structural integrity impairment of cement in gas wells. Conclusion: Despite a growing body of evidence, data gaps persist. Most important, there is a need for more epidemiological studies to assess associations between risk factors, such as air and water pollution, and health outcomes among populations living in close proximity to shale gas operations. Citation: Shonkoff SB, Hays J, Finkel ML. 2014. Environmental public health dimensions of shale and tight gas development. Environ Health Perspect 122:787–795; http://dx.doi.org/10.1289/ehp.1307866 PMID:24736097

  14. Rationalizing Tight Ligand Binding through Cooperative Interaction Networks

    PubMed Central

    2011-01-01

    Small modifications of the molecular structure of a ligand sometimes cause strong gains in binding affinity to a protein target, rendering a weakly active chemical series suddenly attractive for further optimization. Our goal in this study is to better rationalize and predict the occurrence of such interaction hot-spots in receptor binding sites. To this end, we introduce two new concepts into the computational description of molecular recognition. First, we take a broader view of noncovalent interactions and describe protein–ligand binding with a comprehensive set of favorable and unfavorable contact types, including for example halogen bonding and orthogonal multipolar interactions. Second, we go beyond the commonly used pairwise additive treatment of atomic interactions and use a small world network approach to describe how interactions are modulated by their environment. This approach allows us to capture local cooperativity effects and considerably improves the performance of a newly derived empirical scoring function, ScorpionScore. More importantly, however, we demonstrate how an intuitive visualization of key intermolecular interactions, interaction networks, and binding hot-spots supports the identification and rationalization of tight ligand binding. PMID:22087588

  15. Giant stretchability and reversibility of tightly wound helical carbon nanotubes.

    PubMed

    Wu, Jianyang; He, Jianying; Odegard, Gregory M; Nagao, Shijo; Zheng, Quanshui; Zhang, Zhiliang

    2013-09-18

    There is a surging interest in 3D graphitic nanostructures which possess outstanding properties enabling them to be prime candidates for a new generation of nanodevices and energy-absorbing materials. Here we study the stretching instability and reversibility of tightly wound helical carbon nanotubes (HCNTs) by atomistic simulations. The intercoil van der Waals (vdW) interaction-induced flattening of HCNT walls prior to loading is constrained by the defects coordinated for the curvature formation of helices. The HCNTs exhibit extensive stretchability in the range from 400% to 1000% as a result of two distinct deformation mechanisms depending on the HCNT size. For small HCNTs tremendous deformation is achieved by domino-type partial fracture events, whereas for large HCNTs this is accomplished by stepwise buckling of coils. The formation and fracture of edge-closed graphene ribbons occur at lower temperatures, while at elevated temperatures the highly distributed fracture realizes a phenomenal stretchability. The results of cyclic stretching-reversing simulations of large HCNTs display pronounced hysteresis loops, which produce large energy dissipation via full recovery of buckling and vdW bondings. This study provides physical insights into the origins of high ductility and superior reversibility of hybrid CNT structures. PMID:24016308

  16. Tight-binding model for secondary-ion emission

    SciTech Connect

    Gagliano, E.R.; Goldberg, E.C.; Passeggi, M.C.G.; Ferron, J.

    1985-06-01

    The ionization probability R/sup +/ of atoms ejected from sputtered solid surfaces is analyzed by means of the perturbed-stationary-state method. The system is simulated by a linear cluster in the tight-binding approximation including two kinds of time-dependent parameters: the interaction between the sputtered atom and its nearest neighbor, as well as their site energies. The dynamical wave function is described in terms of a superposition of the molecular eigenstates at each point of the trajectory. A direct analysis of the energies of the molecular orbitals (MO's) allows one to retain only those states whose coupling with the MO which evolves into the atomic state of the ejected atom, and determine the ionization probability, thus reducing the size of the coupled system of equations to be considered. Consequently, the cluster can be taken large enough as to reproduce the bandwidth of a semi-infinite chain, allowing for a selection of parameters which simulate simple metals. We studied R/sup +/ as a function of the velocity of the ejected atom and also its dependence with the work function phi of the substrate. For large velocities or for values phi near to the ionization level of the sputtered atom, an exponential dependence of R/sup +/ is found in both cases.

  17. Stability of spinor Fermi gases in tight waveguides

    SciTech Connect

    Campo, A. del; Muga, J. G.; Girardeau, M. D.

    2007-07-15

    The two- and three-body correlation functions of the ground state of an optically trapped ultracold spin-(1/2) Fermi gas (SFG) in a tight waveguide [one-dimensional (1D) regime] are calculated in the plane of even- and odd-wave coupling constants, assuming a 1D attractive zero-range odd-wave interaction induced by a 3D p-wave Feshbach resonance, as well as the usual repulsive zero-range even-wave interaction stemming from 3D s-wave scattering. The calculations are based on the exact mapping from the SFG to a 'Lieb-Liniger-Heisenberg' model with delta-function repulsions depending on isotropic Heisenberg spin-spin interactions, and indicate that the SFG should be stable against three-body recombination in a large region of the coupling constant plane encompassing parts of both the ferromagnetic and antiferromagnetic phases. However, the limiting case of the fermionic Tonks-Girardeau gas, a spin-aligned 1D Fermi gas with infinitely attractive p-wave interactions, is unstable in this sense. Effects due to the dipolar interaction and a Zeeman term due to a resonance-generating magnetic field do not lead to shrinkage of the region of stability of the SFG.

  18. US Geological Survey publications on western tight gas reservoirs

    SciTech Connect

    Krupa, M.P.; Spencer, C.W.

    1989-02-01

    This bibliography includes reports published from 1977 through August 1988. In 1977 the US Geological Survey (USGS), in cooperation with the US Department of Energy's, (DOE), Western Gas Sands Research program, initiated a geological program to identify and characterize natural gas resources in low-permeability (tight) reservoirs in the Rocky Mountain region. These reservoirs are present at depths of less than 2,000 ft (610 m) to greater than 20,000 ft (6,100 m). Only published reports readily available to the public are included in this report. Where appropriate, USGS researchers have incorporated administrative report information into later published studies. These studies cover a broad range of research from basic research on gas origin and migration to applied studies of production potential of reservoirs in individual wells. The early research included construction of regional well-log cross sections. These sections provide a basic stratigraphic framework for individual areas and basins. Most of these sections include drill-stem test and other well-test data so that the gas-bearing reservoirs can be seen in vertical and areal dimensions. For the convenience of the reader, the publications listed in this report have been indexed by general categories of (1) authors, (2) states, (3) geologic basins, (4) cross sections, (5) maps (6) studies of gas origin and migration, (7) reservoir or mineralogic studies, and (8) other reports of a regional or specific topical nature.

  19. Tight Junction Proteins in Human Schwann Cell Autotypic Junctions

    PubMed Central

    Alanne, Maria H.; Pummi, Kati; Heape, Anthony M.; Grènman, Reidar; Peltonen, Juha; Peltonen, Sirkku

    2009-01-01

    Tight junctions (TJs) form physical barriers in various tissues and regulate paracellular transport of ions, water, and molecules. Myelinating Schwann cells form highly organized structures, including compact myelin, nodes of Ranvier, paranodal regions, Schmidt-Lanterman incisures, periaxonal cytoplasmic collars, and mesaxons. Autotypic TJs are formed in non-compacted myelin compartments between adjacent membrane lamellae of the same Schwann cell. Using indirect immunofluorescence and RT-PCR, we analyzed the expression of adherens junction (E-cadherin) and TJ [claudins, zonula occludens (ZO)-1, occludin] components in human peripheral nerve endoneurium, showing clear differences with published rodent profiles. Adult nerve paranodal regions contained E-cadherin, claudin-1, claudin-2, and ZO-1. Schmidt-Lanterman incisures contained E-cadherin, claudin-1, claudin-2, claudin-3, claudin-5, ZO-1, and occludin. Mesaxons contained E-cadherin, claudin-1, claudin-2, claudin-3, ZO-1, and occludin. None of the proteins studied were associated with nodal inter-Schwann cell junctions. Fetal nerve expression of claudin-1, claudin-3, ZO-1, and occludin was predominantly punctate, with a mesaxonal labeling pattern, but paranodal (ZO-1, claudin-3) and Schmidt-Lanterman incisure (claudins-1 and -3) expression profiles typical of compact myelin were visible by gestational week 37. The clear differences observed between human and published rodent nerve profiles emphasize the importance of human studies when translating the results of animal models to human diseases. (J Histochem Cytochem 57:523–529, 2009) PMID:19153196

  20. Diagnosing the tight building syndrome or diagnosing chemical hypersensitivity

    SciTech Connect

    Rogers, S.A. )

    1989-01-01

    The abrupt exposure to urea foam formaldehyde insulation served as an alert to its spectrum of symptoms, including attacks of headache, flushing, laryngitis, dizziness, nausea, extreme weakness or exhaustion, arthralgia, an inability to concentrate, unwarranted depression, arrhythmia, or muscle spasms, and baffled physicians from many specialties. Later it was learned that toluene, xylene, benzene, natural gas, trichloroethylene, and many other chemicals were also capable of triggering chemical hypersensitivity. Other names for this condition include Environmentally Induced Illness (EI), the Tight Building Syndrome (TBS), the Sick Building Syndrome, and Building-Related Illness. The very symptoms patients complain of can be provoked within minutes and then subsequently alleviated with an intradermal injection of the appropriate strength of the triggering chemical. This technique aids in convincing the patient of the EI or TBS triggers so that the patient can begin to relate symptoms to environmental exposures and initiate measure to bring the disease under control. The key to safer buildings is increased ventilation, increased filtration of air, and decreased use of off-gassing synthetic materials.

  1. Na+ transport by rabbit urinary bladder, a tight epithelium.

    PubMed

    Lewis, S A; Diamond, J M

    1976-08-27

    By in vitro experiments on rabbit bladder, we reassessed the traditional view that mammalian urinary bladder lacks ion transport mechanisms. Since the ratio of actual-to-nominal membrane area in folded epithelia is variable and hard to estimate, we normalized membrane properties to apical membrane capacitance rather than to nominal area (probably 1 muF approximately 1 cm2 actual area). A new mounting technique that virtually eliminates edge damage yielded resistances up to 78,000 omega muF for rabbit bladder, and resistances for amphibian skin and bladder much higher than those usually reported. This technique made it possible to observe a transport-related conductance pathway, and a close correlation between transepithelial conductance (G) and short-circuit current (Isc) in these tight epithelia. G and Isc were increased by mucosal (Na+) [Isc approximately 0 when (Na+) approximately 0], aldosterone, serosal (HCO-3) and high mucosal (H+); were decreased by amiloride, mucosal (Ca++), ouabain, metabolic inhibitors and serosal (H+); and were unaffected by (Cl-) and little affected by antidiuretic hormone (ADH). Physiological variation in the rabbits' dietary Na+ intake caused variations in bladder G and Isc similar to those caused by the expected in vivo changes in aldosterone levels. The relation between G and Isc was the same whether defined by diet changes, natural variation among individual rabbits, or most of the above agents. A method was developed for separately resolving conductances of junctions, basolateral cell membrane, and apical cell membrane from this G--Isc relation. Net Na+ flux equalled Isc. Net Cl- flux was zero on short circuit and equalled only 25% of net Na+ flux in open circuit. Bladder membrane fragments contained a Na+-K+-activated, ouabain-inhibited ATPase. The physiological significance of Na+ absorption against steep gradients in rabbit bladder may be to maintain kidney-generated ion gradients during bladder storage of urine, especially

  2. PLEKHA7 modulates epithelial tight junction barrier function

    PubMed Central

    Paschoud, Serge; Jond, Lionel; Guerrera, Diego; Citi, Sandra

    2014-01-01

    PLEKHA7 is a recently identified protein of the epithelial zonula adhaerens (ZA), and is part of a protein complex that stabilizes the ZA, by linking it to microtubules. Since the ZA is important in the assembly and disassembly of tight junctions (TJ), we asked whether PLEKHA7 is involved in modulating epithelial TJ barrier function. We generated clonal MDCK cell lines in which one of four different constructs of PLEKHA7 was inducibly expressed. All constructs were localized at junctions, but constructs lacking the C-terminal region were also distributed diffusely in the cytoplasm. Inducible expression of PLEKHA7 constructs did not affect the expression and localization of TJ proteins, the steady-state value of transepithelial resistance (TER), the development of TER during the calcium switch, and the flux of large molecules across confluent monolayers. In contrast, expression of three out of four constructs resulted both in enhanced recruitment of E-cadherin and associated proteins at the apical ZA and at lateral puncta adherentia (PA), a decreased TER at 18 h after assembly at normal calcium, and an attenuation in the fall in TER after extracellular calcium removal. This latter effect was inhibited when cells were treated with nocodazole. Immunoprecipitation analysis showed that PLEKHA7 forms a complex with the cytoplasmic TJ proteins ZO-1 and cingulin, and this association does not depend on the integrity of microtubules. These results suggest that PLEKHA7 modulates the dynamics of assembly and disassembly of the TJ barrier, through E-cadherin protein complex- and microtubule-dependent mechanisms. PMID:24843844

  3. Tightly Coupled Geodynamic Systems: Software, Implicit Solvers & Applications

    NASA Astrophysics Data System (ADS)

    May, D.; Le Pourhiet, L.; Brown, J.

    2011-12-01

    The generic term "multi-physics" is used to define physical processes which are described by a collection of partial differential equations, or "physics". Numerous processes in geodynamics fall into this category. For example, the evolution of viscous fluid flow and heat transport within the mantle (Stokes flow + energy conservation), the dynamics of melt migration (Stokes flow + Darcy flow + porosity evolution) and landscape evolution (Stokes + diffusion/advection over a surface). The development of software to numerically investigate processes that are described through the composition of different physics components are typically (a) designed for one particular set of physics and are never intended to be extended, or coupled to other processes (b) enforce that certain non-linearity's (or coupling) are explicitly removed from the system for reasons of computational efficiency, or due the lack of a robust non-linear solver (e.g. most models in the mantle convection community). We describe a software infrastructure which enables us to easily introduce new physics with minimal code modifications; tightly couple all physics without introducing splitting errors; exploit modern linear/non-linear solvers and permit the re-use of monolithic preconditioners for individual physics blocks (e.g. saddle point preconditioners for Stokes). Here we present a number of examples to illustrate the flexibility and importance of using this software infra-structure. Using the Stokes system as a prototype, we show results illustrating (i) visco-plastic shear banding experiments, (ii) how coupling Stokes flow with the evolution of the material coordinates can yield temporal stability in the free surface evolution and (iii) the discretisation error associated with decoupling Stokes equation from the heat transport equation in models of mantle convection with various rheologies.

  4. Tight Abo gas sands, east-central New Mexico

    SciTech Connect

    Broadhead, R.F.

    1983-03-01

    Red-bed sandstones of the Abo Formation (Lower Permian) currently produce natural gas from the Pecos Slope Abo field in northern Chaves County, New Mexico. The Pecos Slope Abo field is on the northwest shelf of the Permian basin. The tight-sand designation greatly stimulated drilling and over 250 wells have been drilled since field discovery in 1977. Because of low permeability, wells must be artificially fractured to obtain economic production. Initial production rises from a few tens of MCFGD before fracturing to an average of about 2200 MCFGD after fracturing. The lower granite wash interval is more than 800 ft (248 m) thick in some places and is composed of interbedded coarse-grained arkosic sandstones and arkosic conglomerates. The middle interval is about 100 ft (30 m) thick and conformably overlies the lower interval and the Hueco limestones. It is composed of calcareous, sparsely fossiliferous, argillaceous mudstone and minor fine-grained sandstone. The upper interval is about 600 ft (183 m) thick and is composed of interbedded mudstones and lenticular sandstones. It conformably overlies the middle interval and is disconformably overlain by the dolostones, anhydrites, and fine-grained sandstones of the Yeso Formation. Gas is produced from sandstones in the upper interval. The Abo wells tap a gas-filled natural fracture system. Mudstones seal the fractured sandstone reservoirs. Because fluvial-deltaic deposits extend almost 100 mi (161 km) north of present production, the area underlain by potential, fractured, Abo sandstone reservoirs is at least five times greater than the area which is currently productive.

  5. Pores in the epidermis: aquaporins and tight junctions.

    PubMed

    Brandner, J M

    2007-12-01

    Water homeostasis of the epidermis is important for the appearance and physical properties of the skin, as well as for water balance in the body. It depends on several factors, e.g. barrier quality, uptake of water into the epidermis, concentration of water-retaining humectants, and external humidity. Aquaporins (AQPs) are pores in the plasmamembranes of cells. Monomeric AQPs form barrel-like structures that are primarily water selective, some AQPs also transport glycerol and possibly other small solutes. In the epidermis, AQP3 is the predominant AQP. It is localized mainly in basal but also in suprabasal layers of the epidermis and is permeable for water as well as for glycerol, a humectant. Mice deficient in AQP3 exhibit reduced stratum corneum (SC) hydration and impaired SC barrier recovery after SC removal. In skin diseases associated with elevated transepidermal water loss (TEWL) and reduced SC hydration, altered expression of AQP3 was shown. Tight junctions (TJ) are cell-cell junctions, which play a central role in sealing the intercellular space of cell sheets and thereby establishing a paracellular barrier. Within the TJ, pores are postulated to exist, which allow the controlled diffusion of water and solutes via the paracellular pathway. In the epidermis, TJ structures were demonstrated in the stratum granulosum whereas TJ proteins were found in all viable layers. Mice which overexpress or are deficient of key-proteins of TJ die soon after birth because of a tremendous TEWL. In various skin diseases that are accompanied by elevated TEWL and reduced skin hydration, staining patterns of TJ proteins are altered. This review will summarize our current knowledge of the involvement of AQPs and TJ in the water homeostasis of the epidermis. PMID:18489380

  6. Naturally fractured tight gas reservoir detection optimization. Final report

    SciTech Connect

    1997-11-19

    This DOE-funded research into seismic detection of natural fractures is one of six projects within the DOE`s Detection and Analysis of Naturally Fractured Gas Reservoirs Program, a multidisciplinary research initiative to develop technology for prediction, detection, and mapping of naturally fractured gas reservoirs. The demonstration of successful seismic techniques to locate subsurface zones of high fracture density and to guide drilling orientation for enhanced fracture permeability will enable better returns on investments in the development of the vast gas reserves held in tight formations beneath the Rocky Mountains. The seismic techniques used in this project were designed to capture the azimuthal anisotropy within the seismic response. This seismic anisotropy is the result of the symmetry in the rock fabric created by aligned fractures and/or unequal horizontal stresses. These results may be compared and related to other lines of evidence to provide cross-validation. The authors undertook investigations along the following lines: Characterization of the seismic anisotropy in three-dimensional, P-wave seismic data; Characterization of the seismic anisotropy in a nine-component (P- and S-sources, three-component receivers) vertical seismic profile; Characterization of the seismic anisotropy in three-dimensional, P-to-S converted wave seismic data (P-wave source, three-component receivers); and Description of geological and reservoir-engineering data that corroborate the anisotropy: natural fractures observed at the target level and at the surface, estimation of the maximum horizontal stress in situ, and examination of the flow characteristics of the reservoir.

  7. Tight Chk1 Levels Control Replication Cluster Activation in Xenopus

    PubMed Central

    Wiggins, Jennifer M.; Barbosa, Pedro; Libeau, Pierre; Priam, Pierre; Narassimprakash, Hemalatha; Grodzenski, Xenia; Marheineke, Kathrin

    2015-01-01

    DNA replication in higher eukaryotes initiates at thousands of origins according to a spatio-temporal program. The ATR/Chk1 dependent replication checkpoint inhibits the activation of later firing origins. In the Xenopus in vitro system initiations are not sequence dependent and 2-5 origins are grouped in clusters that fire at different times despite a very short S phase. We have shown that the temporal program is stochastic at the level of single origins and replication clusters. It is unclear how the replication checkpoint inhibits late origins but permits origin activation in early clusters. Here, we analyze the role of Chk1 in the replication program in sperm nuclei replicating in Xenopus egg extracts by a combination of experimental and modelling approaches. After Chk1 inhibition or immunodepletion, we observed an increase of the replication extent and fork density in the presence or absence of external stress. However, overexpression of Chk1 in the absence of external replication stress inhibited DNA replication by decreasing fork densities due to lower Cdk2 kinase activity. Thus, Chk1 levels need to be tightly controlled in order to properly regulate the replication program even during normal S phase. DNA combing experiments showed that Chk1 inhibits origins outside, but not inside, already active clusters. Numerical simulations of initiation frequencies in the absence and presence of Chk1 activity are consistent with a global inhibition of origins by Chk1 at the level of clusters but need to be combined with a local repression of Chk1 action close to activated origins to fit our data. PMID:26046346

  8. Tight junctions in Hailey-Hailey and Darier's diseases

    PubMed Central

    Raiko, Laura; Leinonen, Pekka; Hägg, Päivi M.; Peltonen, Juha; Oikarinen, Aarne; Peltonen, Sirkku

    2009-01-01

    Hailey-Hailey disease (HHD) and Darier's disease (DD) are caused by mutations in Ca2+-ATPases with the end result of desmosomal disruption and suprabasal acantholysis. Tight junctions (TJ) are located in the granular cell layer in normal skin and contribute to the epidermal barrier. Aberrations in the epidermal differentiation, such as in psoriasis, have been shown to lead to changes in the expression of TJ components. Our aim was to elucidate the expression and dynamics of the TJ proteins during the disruption of desmosomes in HHD and DD lesions. Indirect immunofluorescence and avidin-biotin labeling for TJ, desmosomal and adherens junction proteins, and subsequent analyses with the confocal laser scanning microscope were carried out on 14 HHD and 14 DD skin samples. Transepidermal water loss (TEWL) was measured in normal and lesional epidermis of nine HHD and eight DD patients to evaluate the function of the epidermal barrier in HHD and DD skin. The localization of TJ proteins claudin-1, claudin-4, ZO-1, and occludin in perilesional HHD and DD epidermis was similar to that previously described in normal skin. In HHD lesions the tissue distribution of ZO-1 expanded to the acantholytic spinous cells. In agreement with previous findings, desmoplakin was localized intracellularly. In contrast claudin-1 and ZO-1 persisted in the cell-cell contact sites of acantholytic cells. TEWL was increased in the lesional skin. The current results suggest that TJ components follow different dynamics in acantholysis of HHD and DD compared to desmosomal and adherens junction proteins. PMID:25386233

  9. Conservative tightly-coupled simulations of stochastic multiscale systems

    NASA Astrophysics Data System (ADS)

    Taverniers, Søren; Pigarov, Alexander Y.; Tartakovsky, Daniel M.

    2016-05-01

    Multiphysics problems often involve components whose macroscopic dynamics is driven by microscopic random fluctuations. The fidelity of simulations of such systems depends on their ability to propagate these random fluctuations throughout a computational domain, including subdomains represented by deterministic solvers. When the constituent processes take place in nonoverlapping subdomains, system behavior can be modeled via a domain-decomposition approach that couples separate components at the interfaces between these subdomains. Its coupling algorithm has to maintain a stable and efficient numerical time integration even at high noise strength. We propose a conservative domain-decomposition algorithm in which tight coupling is achieved by employing either Picard's or Newton's iterative method. Coupled diffusion equations, one of which has a Gaussian white-noise source term, provide a computational testbed for analysis of these two coupling strategies. Fully-converged ("implicit") coupling with Newton's method typically outperforms its Picard counterpart, especially at high noise levels. This is because the number of Newton iterations scales linearly with the amplitude of the Gaussian noise, while the number of Picard iterations can scale superlinearly. At large time intervals between two subsequent inter-solver communications, the solution error for single-iteration ("explicit") Picard's coupling can be several orders of magnitude higher than that for implicit coupling. Increasing the explicit coupling's communication frequency reduces this difference, but the resulting increase in computational cost can make it less efficient than implicit coupling at similar levels of solution error, depending on the communication frequency of the latter and the noise strength. This trend carries over into higher dimensions, although at high noise strength explicit coupling may be the only computationally viable option.

  10. Student-Friendly Precision Pendulum.

    ERIC Educational Resources Information Center

    Peters, Randall D.

    1999-01-01

    Provides information to help students easily measure gravitational field strength to a few parts in 10,000, a degree of precision 1-2 orders of magnitude better than can be achieved with the simple pendulum. (CCM)

  11. Watch the Children: Precision Referring

    ERIC Educational Resources Information Center

    Hiltbrunner, Curtis L.; Vasa, Stanley F.

    1974-01-01

    The Precision Referral Form (PRF) is described as a quick, accurate and easy instrument that enables teachers to communicate learning and behavior problems of students to resource or ancillary personnel and to pinpoint students' behaviors. (GW)

  12. Precision Instrument and Equipment Repairers.

    ERIC Educational Resources Information Center

    Wyatt, Ian

    2001-01-01

    Explains the job of precision instrument and equipment repairers, who work on cameras, medical equipment, musical instruments, watches and clocks, and industrial measuring devices. Discusses duties, working conditions, employment and earnings, job outlook, and skills and training. (JOW)

  13. Precision GPS ephemerides and baselines

    NASA Technical Reports Server (NTRS)

    1991-01-01

    Based on the research, the area of precise ephemerides for GPS satellites, the following observations can be made pertaining to the status and future work needed regarding orbit accuracy. There are several aspects which need to be addressed in discussing determination of precise orbits, such as force models, kinematic models, measurement models, data reduction/estimation methods, etc. Although each one of these aspects was studied at CSR in research efforts, only points pertaining to the force modeling aspect are addressed.

  14. High Precision Electon Beam Polarimetry

    NASA Astrophysics Data System (ADS)

    Dutta, D.

    2016-02-01

    Over the last three decades high precision electron beam polarimetry has been at the fore-front of progress made in leveraging the spin degrees of freedom in nuclear and particle physics experiments. We review the three main types of polarimeters, Compton, Møller and Mott, that are typically used in experiments. We discuss some of the recent results in high precision electron polarimetry and some of the new ideas that are being explored for future application at current and proposed accelerators.

  15. High-precision spectroscopy of ultracold molecules in an optical lattice

    NASA Astrophysics Data System (ADS)

    McGuyer, B. H.; McDonald, M.; Iwata, G. Z.; Tarallo, M. G.; Grier, A. T.; Apfelbeck, F.; Zelevinsky, T.

    2015-05-01

    The study of ultracold molecules tightly trapped in an optical lattice can expand the frontier of precision measurement and spectroscopy, and provide a deeper insight into molecular and fundamental physics. Here we create, probe, and image microkelvin 88Sr2 molecules in a lattice, and demonstrate precise measurements of molecular parameters as well as coherent control of molecular quantum states using optical fields. We discuss the sensitivity of the system to dimensional effects, a new bound-to-continuum spectroscopy technique for highly accurate binding energy measurements, and prospects for new physics with this rich experimental system.

  16. AMP-activated protein kinase regulates the assembly of epithelial tight junctions.

    PubMed

    Zhang, Li; Li, Ji; Young, Lawrence H; Caplan, Michael J

    2006-11-14

    AMP activated protein kinase (AMPK), a sensor of cellular energy status in all eukaryotic cells, is activated by LKB1-dependent phosphorylation. Recent studies indicate that activated LKB1 induces polarity in epithelial cells and that this polarization is accompanied by the formation of tight junction structures. We wished to determine whether AMPK also contributes to the assembly of tight junctions in the epithelial cell polarization process. We found that AMPK is activated during calcium-induced tight junction assembly. Activation of AMPK by 5-aminoimidazole-4-carboxamide ribonucleoside facilitates tight junction assembly under conditions of normal extracellular Ca2+ concentrations and initiates tight junction assembly in the absence of Ca2+ as revealed by the relocation of zonula occludens 1, the establishment of transepithelial electrical resistance, and the paracellular flux assay. Expression of a dominant negative AMPK construct inhibits tight junction assembly in MDCK cells, and this defect in tight junction assembly can be partially ameliorated by rapamycin. These results suggest that AMPK plays a role in the regulation of tight junction assembly. PMID:17088526

  17. Exploring a Transformative Orientation to Sustainability in Universities: A Question of Loose and Tight Framings

    ERIC Educational Resources Information Center

    Scott, William A. H.

    2015-01-01

    This review essay examines three new books on higher education and sustainability. It explores a number of the issues raised in the books, in particular, the meaning of a transformative orientation towards sustainability. The idea of loose and tight conceptual framings of sustainability is employed. A tight framing is where an institution embodies…

  18. Superoxide mediates tight junction complex dissociation in cyclically stretched lung slices.

    PubMed

    Song, Min Jae; Davidovich, Nurit; Lawrence, Gladys G; Margulies, Susan S

    2016-05-24

    We found that stretching Type I rat alveolar epithelial cell (RAEC) monolayers at magnitudes that correspond to high tidal-volume mechanical ventilation results in the production of reactive oxygen species, including nitric oxide and superoxide. Scavenging superoxide with Tiron eliminated the stretch-induced increase in cell monolayer permeability, and similar results were reported for rats ventilated at large tidal volumes, suggesting that oxidative stress plays an important role in barrier impairment in ventilator-induced lung injury associated with large stretch and tidal volumes. In this communication we show that mechanisms that involve oxidative injury are also present in a novel precision cut lung slices (PCLS) model under identical mechanical loads. PCLSs from healthy rats were stretched cyclically to 37% change in surface area for 1 hour. Superoxide was visualized using MitoSOX. To evaluate functional relationships, in separate stretch studies superoxide was scavenged using Tiron or mito-Tempo. PCLS and RAEC permeability was assessed as tight junction (TJ) protein (occludin, claudin-4 and claudin-7) dissociation from zona occludins-1 (ZO-1) via co-immunoprecipitation and Western blot, after 1h (PCLS) or 10min (RAEC) of stretch. Superoxide was increased significantly in PCLS, and Tiron and mito-Tempo dramatically attenuated the response, preventing claudin-4 and claudin-7 dissociation from ZO-1. Using a novel PCLS model for ventilator-induced lung injury studies, we have shown that uniform, biaxial, cyclic stretch generates ROS in the slices, and that superoxide scavenging that can protect the lung tissue under stretch conditions. We conclude that PCLS offer a valuable platform for investigating antioxidant treatments to prevent ventilation-induced lung injury. PMID:26592435

  19. Across-Time Change and Variation in Cultural Tightness-Looseness.

    PubMed

    Mandel, Anne; Realo, Anu

    2015-01-01

    Cultural tightness-looseness, a dimension which describes the strength, multitude, and clarity of social norms in a culture, has proved significant in explaining differences between cultures. Although several studies have compared different cultures on this domain, this study is the first that targets both within-country differences and across-time variation in tightness-looseness. Using data from two nationally representative samples of Estonians, we found that the general tightness level had changed over a period of 10 years but the effect size of the change was small. A significant within country variance in 2002 had disappeared by 2012. Our results suggest that tightness-looseness, similarly to cultural value orientations, is a relatively stable and robust characteristic of culture-that is, change indeed takes place, but slowly. Future studies about across-time change and within-country variance in tightness-looseness should target more culturally diverse and socially divided societies. PMID:26683813

  20. Across-Time Change and Variation in Cultural Tightness-Looseness

    PubMed Central

    Mandel, Anne; Realo, Anu

    2015-01-01

    Cultural tightness-looseness, a dimension which describes the strength, multitude, and clarity of social norms in a culture, has proved significant in explaining differences between cultures. Although several studies have compared different cultures on this domain, this study is the first that targets both within-country differences and across-time variation in tightness-looseness. Using data from two nationally representative samples of Estonians, we found that the general tightness level had changed over a period of 10 years but the effect size of the change was small. A significant within country variance in 2002 had disappeared by 2012. Our results suggest that tightness-looseness, similarly to cultural value orientations, is a relatively stable and robust characteristic of culture–that is, change indeed takes place, but slowly. Future studies about across-time change and within-country variance in tightness-looseness should target more culturally diverse and socially divided societies. PMID:26683813

  1. Transferable tight-binding model for strained group IV and III-V materials and heterostructures

    NASA Astrophysics Data System (ADS)

    Tan, Yaohua; Povolotskyi, Michael; Kubis, Tillmann; Boykin, Timothy B.; Klimeck, Gerhard

    2016-07-01

    It is critical to capture the effect due to strain and material interface for device level transistor modeling. We introduce a transferable s p3d5s* tight-binding model with nearest-neighbor interactions for arbitrarily strained group IV and III-V materials. The tight-binding model is parametrized with respect to hybrid functional (HSE06) calculations for varieties of strained systems. The tight-binding calculations of ultrasmall superlattices formed by group IV and group III-V materials show good agreement with the corresponding HSE06 calculations. The application of the tight-binding model to superlattices demonstrates that the transferable tight-binding model with nearest-neighbor interactions can be obtained for group IV and III-V materials.

  2. Aerodynamic window for high precision laser drilling

    NASA Astrophysics Data System (ADS)

    Sommer, Steffen; Dausinger, Friedrich; Berger, Peter; Hügel, Helmuth

    2007-05-01

    High precision laser drilling is getting more and more interesting for industry. Main applications for such holes are vaporising and injection nozzles. To enhance quality, the energy deposition has to be accurately defined by reducing the pulse duration and thereby reducing the amount of disturbing melting layer. In addition, an appropriate processing technology, for example the helical drilling, yields holes in steel at 1 mm thickness and diameters about 100 μm with correct roundness and thin recast layers. However, the processing times are still not short enough for industrial use. Experiments have shown that the reduction of the atmospheric pressure down to 100 hPa enhances the achievable quality and efficiency, but the use of vacuum chambers in industrial processes is normally quite slow and thus expensive. The possibility of a very fast evacuation is given by the use of an aerodynamic window, which produces the pressure reduction by virtue of its fluid dynamic features. This element, based on a potential vortex, was developed and patented as out-coupling window for high power CO II lasers by IFSW 1, 2, 3. It has excellent tightness and transmission properties, and a beam deflection is not detectable. The working medium is compressed air, only. For the use as vacuum element for laser drilling, several geometrical modifications had to be realized. The prototype is small enough to be integrated in a micromachining station and has a low gas flow. During the laser pulse, which is focussed through the potential flow, a very high fluence is reached, but the measurements have not shown any beam deflection or focal shifting. The evacuation time is below 300 ms so that material treatment with changing ambient pressure is possible, too. Experimental results have proven the positive effect of the reduced ambient pressure on the drilling process for the regime of nano- and picosecond laser pulses. Plasma effects are reduced and, because of the less absorption, the

  3. On-line air-tightness and insertion loss simultaneous detection method of high air-tightness fiber optic penetration connector

    NASA Astrophysics Data System (ADS)

    Zhang, Jingchuan; Yang, Xiaoning; Wang, Jing; Jiang, Junfeng

    2015-08-01

    The high air-tightness multicore fiber optic penetration connector is a core component for the optical fiber sensing and communication technologies applied in the space environment simulator under the vacuum thermal environment. High air-tightness and insertion loss are the two key indexes of the fiber optic penetration connector. The air-tightness and insertion loss on-line synchronous detection method was proposed. First, established hardware-in-the-loop testing platform by using the vacuum pumping system, the vacuum vessel, the helium mass spectrometer leak detector and optical time-domain reflectmeter, then, described the air tightness and insertion loss on-line detection principle, finally, designed a detection test scheme and air-tightness and insertion loss were tested. Experimental results indicate that the leakage rate is lower than 1.0×10-7Pa•L/S, the minimum of which is1.0×10-10Pa•L/S and the insertion loss at wave length window 1550 nm is +/-0.07db, which is less than +/-0.1db. It can lay the data basis for the design of opto-mechanical combination and later period fine processing.

  4. Precise Orbit Determination for ALOS

    NASA Technical Reports Server (NTRS)

    Nakamura, Ryo; Nakamura, Shinichi; Kudo, Nobuo; Katagiri, Seiji

    2007-01-01

    The Advanced Land Observing Satellite (ALOS) has been developed to contribute to the fields of mapping, precise regional land coverage observation, disaster monitoring, and resource surveying. Because the mounted sensors need high geometrical accuracy, precise orbit determination for ALOS is essential for satisfying the mission objectives. So ALOS mounts a GPS receiver and a Laser Reflector (LR) for Satellite Laser Ranging (SLR). This paper deals with the precise orbit determination experiments for ALOS using Global and High Accuracy Trajectory determination System (GUTS) and the evaluation of the orbit determination accuracy by SLR data. The results show that, even though the GPS receiver loses lock of GPS signals more frequently than expected, GPS-based orbit is consistent with SLR-based orbit. And considering the 1 sigma error, orbit determination accuracy of a few decimeters (peak-to-peak) was achieved.

  5. A precision mechanical nerve stimulator

    NASA Technical Reports Server (NTRS)

    Tcheng, Ping; Supplee, Frank H., Jr.; Prass, Richard L.

    1988-01-01

    An electromechanical device, used to apply and monitor stimulating pulses to a mammalian motor nerve, has been successfully developed at NASA Langley Research Center. Two existing force transducers, a flight skin friction balance and a miniature skin friction balance which were designed for making aerodynamic drag measurements, were modified and incorporated to form this precision instrument. The nerve stimulator is a type one servomechanism capable of applying and monitoring stimulating pulses of 0 to 10 grams with a precision of better than +/- 0.05 grams. Additionally, the device can be independently used to apply stimulating pulses by displacing the nerve from 0 to 0.25 mm with a precision of better than +/- 0.001 mm while measuring the level of the load applied.

  6. Kinematic precision of gear trains

    NASA Technical Reports Server (NTRS)

    Litvin, F. L.; Goldrich, R. N.; Coy, J. J.; Zaretsky, E. V.

    1982-01-01

    Kinematic precision is affected by errors which are the result of either intentional adjustments or accidental defects in manufacturing and assembly of gear trains. A method for the determination of kinematic precision of gear trains is described. The method is based on the exact kinematic relations for the contact point motions of the gear tooth surfaces under the influence of errors. An approximate method is also explained. Example applications of the general approximate methods are demonstrated for gear trains consisting of involute (spur and helical) gears, circular arc (Wildhaber-Novikov) gears, and spiral bevel gears. Gear noise measurements from a helicopter transmission are presented and discussed with relation to the kinematic precision theory.

  7. Precision cleaning apparatus and method

    DOEpatents

    Schneider, T.W.; Frye, G.C.; Martin, S.J.

    1998-01-13

    A precision cleaning apparatus and method are disclosed. The precision cleaning apparatus includes a cleaning monitor further comprising an acoustic wave cleaning sensor such as a quartz crystal microbalance (QCM), a flexural plate wave (FPW) sensor, a shear horizontal acoustic plate mode (SH--APM) sensor, or a shear horizontal surface acoustic wave (SH--SAW) sensor; and measurement means connectable to the sensor for measuring in-situ one or more electrical response characteristics that vary in response to removal of one or more contaminants from the sensor and a workpiece located adjacent to the sensor during cleaning. Methods are disclosed for precision cleaning of one or more contaminants from a surface of the workpiece by means of the cleaning monitor that determines a state of cleanliness and any residual contamination that may be present after cleaning; and also for determining an effectiveness of a cleaning medium for removing one or more contaminants from a workpiece. 11 figs.

  8. Precision cleaning apparatus and method

    DOEpatents

    Schneider, Thomas W.; Frye, Gregory C.; Martin, Stephen J.

    1998-01-01

    A precision cleaning apparatus and method. The precision cleaning apparatus includes a cleaning monitor further comprising an acoustic wave cleaning sensor such as a quartz crystal microbalance (QCM), a flexural plate wave (FPW) sensor, a shear horizontal acoustic plate mode (SH--APM) sensor, or a shear horizontal surface acoustic wave (SH--SAW) sensor; and measurement means connectable to the sensor for measuring in-situ one or more electrical response characteristics that vary in response to removal of one or more contaminants from the sensor and a workpiece located adjacent to the sensor during cleaning. Methods are disclosed for precision cleaning of one or more contaminants from a surface of the workpiece by means of the cleaning monitor that determines a state of cleanliness and any residual contamination that may be present after cleaning; and also for determining an effectiveness of a cleaning medium for removing one or more contaminants from a workpiece.

  9. Kinematic precision of gear trains

    NASA Technical Reports Server (NTRS)

    Litvin, F. L.; Goldrich, R. N.; Coy, J. J.; Zaretsky, E. V.

    1983-01-01

    Kinematic precision is affected by errors which are the result of either intentional adjustments or accidental defects in manufacturing and assembly of gear trains. A method for the determination of kinematic precision of gear trains is described. The method is based on the exact kinematic relations for the contact point motions of the gear tooth surfaces under the influence of errors. An approximate method is also explained. Example applications of the general approximate methods are demonstrated for gear trains consisting of involute (spur and helical) gears, circular arc (Wildhaber-Novikov) gears, and spiral bevel gears. Gear noise measurements from a helicopter transmission are presented and discussed with relation to the kinematic precision theory. Previously announced in STAR as N82-32733

  10. TURNING PRECISION AGRICULTURE INFORMATION INTO PRECISION CONSERVATION DECISIONS

    Technology Transfer Automated Retrieval System (TEKTRAN)

    For over a decade (1991-2003), precision agriculture methods were used to intensively monitor crop, soil, and water quality information on a typical claypan-soil field in Missouri. Many field properties were found to vary greatly within this somewhat flat, uniform-looking field, including grain yiel...

  11. ELECTROWEAK PHYSICS AND PRECISION STUDIES.

    SciTech Connect

    MARCIANO, W.

    2005-10-24

    The utility of precision electroweak measurements for predicting the Standard Model Higgs mass via quantum loop effects is discussed. Current values of m{sub W}, sin{sup 2} {theta}{sub W}(m{sub Z}){sub {ovr MS}} and m{sub t} imply a relatively light Higgs which is below the direct experimental bound but possibly consistent with Supersymmetry expectations. The existence of Supersymmetry is further suggested by a 2{sigma} discrepancy between experiment and theory for the muon anomalous magnetic moment. Constraints from precision studies on other types of ''New Physics'' are also briefly described.

  12. Precision protection through indirect correlations

    NASA Astrophysics Data System (ADS)

    Jin, Yao

    2016-04-01

    The dynamics of the quantum Fisher information of the parameters of the initial atomic state is studied, in the framework of open quantum systems, for a pair of static two-level atoms coupled to a bath of fluctuating vacuum scalar fields. Our results show that the correlations between the two atoms as well as the precision limit in quantum metrology are determined by the separation between the two atoms. Remarkably, when the separation between the two atoms approaches zero, the quantum Fisher information, thus the precision limit of the estimation of the parameters of the initial atomic state will be survived from the vacuum fluctuations after long time evolution.

  13. PRECISION RADIAL VELOCITIES WITH CSHELL

    SciTech Connect

    Crockett, Christopher J.; Prato, L.; Mahmud, Naved I.; Johns-Krull, Christopher M.; Jaffe, Daniel T.; Beichman, Charles A. E-mail: lprato@lowell.edu E-mail: cmj@rice.edu

    2011-07-10

    Radial velocity (RV) identification of extrasolar planets has historically been dominated by optical surveys. Interest in expanding exoplanet searches to M dwarfs and young stars, however, has motivated a push to improve the precision of near-infrared RV techniques. We present our methodology for achieving 58 m s{sup -1} precision in the K band on the M0 dwarf GJ 281 using the CSHELL spectrograph at the 3 m NASA Infrared Telescope Facility. We also demonstrate our ability to recover the known 4 M{sub JUP} exoplanet Gl 86 b and discuss the implications for success in detecting planets around 1-3 Myr old T Tauri stars.

  14. Universal precision sine bar attachment

    NASA Technical Reports Server (NTRS)

    Mann, Franklin D. (Inventor)

    1989-01-01

    This invention relates to an attachment for a sine bar which can be used to perform measurements during lathe operations or other types of machining operations. The attachment can be used for setting precision angles on vises, dividing heads, rotary tables and angle plates. It can also be used in the inspection of machined parts, when close tolerances are required, and in the layout of precision hardware. The novelty of the invention is believed to reside in a specific versatile sine bar attachment for measuring a variety of angles on a number of different types of equipment.

  15. Top Compositeness and Precision Unification

    NASA Astrophysics Data System (ADS)

    Agashe, Kaustubh; Contino, Roberto; Sundrum, Raman

    2005-10-01

    The evolution of standard model gauge couplings is studied in a nonsupersymmetric scenario in which the hierarchy problem is resolved by Higgs compositeness above the weak scale. It is argued that massiveness of the top quark combined with precision tests of the bottom quark imply that the right-handed top must also be composite. If, further, the standard model gauge symmetry is embedded into a simple subgroup of the unbroken composite-sector flavor symmetry, then precision coupling unification is shown to occur at ˜1015GeV, to a degree comparable to supersymmetric unification.

  16. Microbiopsy/precision cutting devices

    DOEpatents

    Krulevitch, P.A.; Lee, A.P.; Northrup, M.A.; Benett, W.J.

    1999-07-27

    Devices are disclosed for performing tissue biopsy on a small scale (microbiopsy). By reducing the size of the biopsy tool and removing only a small amount of tissue or other material in a minimally invasive manner, the risks, costs, injury and patient discomfort associated with traditional biopsy procedures can be reduced. By using micromachining and precision machining capabilities, it is possible to fabricate small biopsy/cutting devices from silicon. These devices can be used in one of four ways (1) intravascularly, (2) extravascularly, (3) by vessel puncture, and (4) externally. Additionally, the devices may be used in precision surgical cutting. 6 figs.

  17. Microbiopsy/precision cutting devices

    DOEpatents

    Krulevitch, Peter A.; Lee, Abraham P.; Northrup, M. Allen; Benett, William J.

    1999-01-01

    Devices for performing tissue biopsy on a small scale (microbiopsy). By reducing the size of the biopsy tool and removing only a small amount of tissue or other material in a minimally invasive manner, the risks, costs, injury and patient discomfort associated with traditional biopsy procedures can be reduced. By using micromachining and precision machining capabilities, it is possible to fabricate small biopsy/cutting devices from silicon. These devices can be used in one of four ways 1) intravascularly, 2) extravascularly, 3) by vessel puncture, and 4) externally. Additionally, the devices may be used in precision surgical cutting.

  18. Terrestrial tight oil reservoir characteristics and Graded Resource Assessment in China

    NASA Astrophysics Data System (ADS)

    Wang, Shejiao; Wu, Xiaozhi; Guo, Giulin

    2016-04-01

    The success of shale/tight plays and the advanced exploitation technology applied in North America have triggered interest in exploring and exploiting tight oil in China. Due to the increased support of exploration and exploitation,great progress has been made in Erdos basin, Songliao basin, Junggar basin, Santanghu basin, Bohai Bay basin, Qaidam Basin, and Sichuan basin currently. China's first tight oil field has been found in Erdos basin in 2015, called xinanbian oil field, with over one hundred million tons oil reserves and one million tons of production scale. Several hundred million tons of tight oil reserve has been found in other basins, showing a great potential in China. Tight oil in China mainly developed in terrestrial sedimentary environment. According to the relations of source rock and reservoir, the source-reservoir combination of tight oil can be divided into three types, which are bottom generating and top storing tight oil,self- generating and self-storing tight oil,top generating and bottom storing tight oil. The self- generating and self-storing tight oil is the main type discovered at present. This type of tight oil has following characteristics:(1) The formation and distribution of tight oil are controlled by high quality source rocks. Terrestrial tight oil source rocks in China are mainly formed in the deep to half deep lacustrine facies. The lithology includes dark mudstone, shale, argillaceous limestone and dolomite. These source rocks with thickness between 20m-150m, kerogen type mostly I-II, and peak oil generation thermal maturity(Ro 0.6-1.4%), have great hydrocarbon generating potential. Most discovered tight oil is distributed in the area of TOC greater than 2 %.( 2) the reservoir with strong heterogeneity is very tight. In these low porosity and permeability reservoir,the resources distribution is controlled by the physical property. Tight sandstone, carbonate and hybrid sedimentary rocks are three main tight reservoir types in

  19. Quantification of posterior capsule tightness and motion loss in patients with shoulder impingement.

    PubMed

    Tyler, T F; Nicholas, S J; Roy, T; Gleim, G W

    2000-01-01

    The relationship between posterior capsule tightness and dysfunction has long been recognized clinically but has not been biometrically quantified. The purpose of this study was to quantify changes in range of motion and posterior capsule tightness in patients with dominant or nondominant shoulder impingement. Measurements of posterior capsule tightness and external and internal rotation range of motion were made in 31 patients with shoulder impingement and in 33 controls without shoulder abnormality. Patients with impingement in the nondominant arm had increased posterior capsule tightness and decreased internal and external rotation range of motion compared with controls. Patients with impingement in their dominant arm had increased posterior capsule tightness and reduced internal rotation range of motion but no significant loss of external rotation range of motion compared with controls. Posterior capsule tightness in impingement patients showed a significant correlation with loss of internal rotation range of motion. Patients with shoulder impingement in their nondominant arm had a more global loss of range of motion compared with patients having impingement in their dominant arm. We believe we have described a valid clinical measurement for identifying posterior capsule tightness in patients with shoulder impingement. PMID:11032222

  20. Access Analysis-Based Tight Localization of Abstract Memories

    NASA Astrophysics Data System (ADS)

    Oh, Hakjoo; Brutschy, Lucas; Yi, Kwangkeun

    On-the-fly localization of abstract memory states is vital for economical abstract interpretation of imperative programs. Such localization is sometimes called "abstract garbage collection" or "framing". In this article we present a new memory localization technique that is more effective than the conventional reachability-based approach. Our technique is based on a key observation that collecting the reachable memory parts is too conservative and the accessed parts are usually tiny subsets of the reachable. Our technique first estimates, by an efficient pre-analysis, the set of locations that will be accessed during the analysis of each code block. Then the main analysis uses the access-set results to trim the memory entries before analyzing code blocks. In experiments with an industrial-strength global C static analyzer, the technique is applied right before analyzing each procedure's body and reduces the average analysis time and memory by 92.1% and 71.2%, respectively, without sacrificing the analysis precision. Localizing more frequently such as at loop bodies and basic blocks as well as procedure bodies, the generalized localization additionally reduces analysis time by an average of 31.8%.

  1. Precision luminosity measurements at LHCb

    NASA Astrophysics Data System (ADS)

    The LHCb Collaboration

    2014-12-01

    Measuring cross-sections at the LHC requires the luminosity to be determined accurately at each centre-of-mass energy √s. In this paper results are reported from the luminosity calibrations carried out at the LHC interaction point 8 with the LHCb detector for √s = 2.76, 7 and 8 TeV (proton-proton collisions) and for √sNN = 5 TeV (proton-lead collisions). Both the "van der Meer scan" and "beam-gas imaging" luminosity calibration methods were employed. It is observed that the beam density profile cannot always be described by a function that is factorizable in the two transverse coordinates. The introduction of a two-dimensional description of the beams improves significantly the consistency of the results. For proton-proton interactions at √s = 8 TeV a relative precision of the luminosity calibration of 1.47% is obtained using van der Meer scans and 1.43% using beam-gas imaging, resulting in a combined precision of 1.12%. Applying the calibration to the full data set determines the luminosity with a precision of 1.16%. This represents the most precise luminosity measurement achieved so far at a bunched-beam hadron collider.

  2. Precision Machining Technology. Curriculum Guide.

    ERIC Educational Resources Information Center

    Idaho State Dept. of Education, Boise. Div. of Vocational Education.

    This curriculum guide was developed from a Technical Committee Report prepared with the assistance of industry personnel and containing a Task List which is the basis of the guide. It presents competency-based program standards for courses in precision machining technology and is part of the Idaho Vocational Curriculum Guide Project, a cooperative…

  3. Precision Cleaning - Path to Premier

    NASA Technical Reports Server (NTRS)

    Mackler, Scott E.

    2008-01-01

    ITT Space Systems Division s new Precision Cleaning facility provides critical cleaning and packaging of aerospace flight hardware and optical payloads to meet customer performance requirements. The Precision Cleaning Path to Premier Project was a 2007 capital project and is a key element in the approved Premier Resource Management - Integrated Supply Chain Footprint Optimization Project. Formerly precision cleaning was located offsite in a leased building. A new facility equipped with modern precision cleaning equipment including advanced process analytical technology and improved capabilities was designed and built after outsourcing solutions were investigated and found lacking in ability to meet quality specifications and schedule needs. SSD cleans parts that can range in size from a single threaded fastener all the way up to large composite structures. Materials that can be processed include optics, composites, metals and various high performance coatings. We are required to provide verification to our customers that we have met their particulate and molecular cleanliness requirements and we have that analytical capability in this new facility. The new facility footprint is approximately half the size of the former leased operation and provides double the amount of throughput. Process improvements and new cleaning equipment are projected to increase 1st pass yield from 78% to 98% avoiding $300K+/yr in rework costs. Cost avoidance of $350K/yr will result from elimination of rent, IT services, transportation, and decreased utility costs. Savings due to reduced staff expected to net $4-500K/yr.

  4. Precision GPS ephemerides and baselines

    NASA Technical Reports Server (NTRS)

    1992-01-01

    The emphasis of this grant was focused on precision ephemerides for the Global Positioning System (GPS) satellites for geodynamics applications. During the period of this grant, major activities were in the areas of thermal force modeling, numerical integration accuracy improvement for eclipsing satellites, analysis of GIG '91 campaign data, and the Southwest Pacific campaign data analysis.

  5. Precision Efficacy Analysis for Regression.

    ERIC Educational Resources Information Center

    Brooks, Gordon P.

    When multiple linear regression is used to develop a prediction model, sample size must be large enough to ensure stable coefficients. If the derivation sample size is inadequate, the model may not predict well for future subjects. The precision efficacy analysis for regression (PEAR) method uses a cross- validity approach to select sample sizes…

  6. Sensor fusion for precision agriculture

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Information-based management of crop production systems known as precision agriculture relies on different sensor technologies aimed at characterization of spatial heterogeneity of a cropping environment. Remote and proximal sensing systems have been deployed to obtain high-resolution data pertainin...

  7. Precision Agriculture and Nutrient Cycling

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Precision agriculture (PA) refers to the practice of managing agronomic inputs according to specific needs across the landscape. The major impediment to implement the adoption of PA is the development of decision-support systems. One way to achieve this objective is to integrate crop simulation mode...

  8. Spin and precision electroweak physics

    SciTech Connect

    Marciano, W.J.

    1993-12-31

    A perspective on fundamental parameters and precision tests of the Standard Model is given. Weak neutral current reactions are discussed with emphasis on those processes involving (polarized) electrons. The role of electroweak radiative corrections in determining the top quark mass and probing for ``new physics`` is described.

  9. Precision orbit computations for Starlette

    NASA Technical Reports Server (NTRS)

    Marsh, J. G.; Williamson, R. G.

    1976-01-01

    The Starlette satellite, launched in February 1975 by the French Centre National d'Etudes Spatiales, was designed to minimize the effects of nongravitational forces and to obtain the highest possible accuracy for laser range measurements. Analyses of the first four months of global laser tracking data confirmed the stability of the orbit and the precision to which the satellite's position is established.

  10. Paving the road for hydraulic fracturing in Paleozoic tight gas reservoirs in Abu Dhabi

    NASA Astrophysics Data System (ADS)

    Alzarouni, Asim

    This study contributes to the ongoing efforts of Abu Dhabi National Oil Company (ADNOC) to improve gas production and supply in view of increasing demand and diminishing conventional gas reservoirs in the region. The conditions of most gas reservoirs with potentially economical volumes of gas in Abu Dhabi are tight abrasive deep sand reservoirs at high temperature and pressures. Thus it inevitably tests the limit of both conventional thinking and technology. Accurate prediction of well performance is a major challenge that arises during planning phase. The primary aim is to determine technical feasibility for the implementation of the hydraulic fracture technology in a new area. The ultimate goal is to make economical production curves possible and pave the road to tap new resource of clean hydrocarbon energy source. The formation targeted in this study is characterized by quartzitic sandstone layers and variably colored shale and siltstones with thin layers of anhydrites. It dates back from late Permian to Carboniferous age. It forms rocks at the lower reservoir permeability ranging from 0.2 to less than 1 millidarcy (mD). When fractured, the expected well flow in Abu Dhabi offshore deep gas wells will be close to similar tight gas reservoir in the region. In other words, gas production can be described as transient initially with high rates and rapidly declining towards a pseudo-steady sustainable flow. The study results estimated fracturing gradient range from 0.85 psi/ft to 0.91 psi/ft. In other words, the technology can be implemented successfully to the expected rating without highly weighted brine. Hence, it would be a remarkable step to conduct the first hydraulic fracturing successfully in Abu Dhabi which can pave the road to tapping on a clean energy resource. The models predicted a remarkable conductivity enhancement and an increase of production between 3 to 4 times after fracturing. Moreover, a sustainable rate above 25 MMSCFD between 6 to 10 years is

  11. Low-energy-spread laser wakefield acceleration using ionization injection with a tightly focused laser in a mismatched plasma channel

    NASA Astrophysics Data System (ADS)

    Li, F.; Zhang, C. J.; Wan, Y.; Wu, Y. P.; Xu, X. L.; Hua, J. F.; Pai, C. H.; Lu, W.; Gu, Y. Q.; Mori, W. B.; Joshi, C.

    2016-03-01

    An improved ionization injection scheme for laser wakefield acceleration using a tightly focused laser pulse, with intensity near the ionization threshold to trigger the injection in a mismatched plasma channel, has been proposed and examined via 3D particle-in-cell (PIC) simulations. In this scheme, the key to achieving a very low energy spread is shortening the injection distance through the fast diffraction of the tightly focused laser. Furthermore, the oscillation of the laser envelope in the mismatched plasma channel can induce multiple low-energy-spread injections with an even distribution in both space and energy. The envelope oscillation can also significantly enhance the energy gain of the injected beams compared to the standard non-evolving wake scenario due to the rephasing between the electron beam and the laser wake. A theoretical model has been derived to precisely predict the injection distance, the ionization degree of injection atoms/ions, the electron yield as well as the ionized charge for given laser-plasma parameters, and such expressions can be directly utilized for optimizing the quality of the injected beam. Through 3D PIC simulations, we show that an injection distance as short as tens of microns can be achieved, which leads to ultrashort fs, few pC electron bunches with a narrow absolute energy spread around 2 MeV (rms). Simulations also show that the initial absolute energy spread remains nearly constant during the subsequent acceleration due to the very short bunch length, and this indicates that further acceleration of the electron bunches up to the GeV level may lead to an electron beam with an energy spread well below 0.5%. Such low-energy-spread electron beams may have potential applications for future coherent light sources driven by laser-plasma accelerators.

  12. Assessment of unconventional tight-gas resources of the Magallanes Basin Province, Chile, 2015

    USGS Publications Warehouse

    Schenk, Christopher J.; Charpentier, Ronald R.; Pitman, Janet K.; Tennyson, Marilyn E.; Brownfield, Michael E.; Gaswirth, Stephanie B.; Le, Phuong A.; Leathers-Miller, Heidi M.; Marra, Kristen R.

    2016-01-01

    Using a geology-based assessment methodology, the U.S. Geological Survey assessed a technically recoverable mean resource of 8.3 trillion cubic feet of unconventional tight gas in the Zona Glauconitica of the Magallanes Basin Province, Chile.

  13. sp3s* Tight-Binding Parameters for Transport Simulations in Compound Semiconductors

    NASA Technical Reports Server (NTRS)

    Klimeck, G.; Bowen, R.; Boykin, T.; Cwik, T.

    1999-01-01

    A genetic algorithm approach is used to fit orbital interaction energies of sp3s* tight-binding models for the nine binary compound semiconductors consistent of Ga, Al, In and As, P, Sb at room temperature.

  14. Summary report for the tank tightness testing of underground storage tanks, Idaho National Engineering Laboratory

    SciTech Connect

    Not Available

    1990-03-01

    Between August 14, 1989, and August 26, 1989, 16 underground storage tanks were tank tightness tested for leaks as part of the Idaho National Engineering Laboratory tank management program. This report summarizes the results of these tank tightness tests, the modifications and repairs made to the tank systems, fuel transfer records, and any problems that affected the tank testing schedule. Of the 16 underground storage tanks tested, five failed the tank tightness test. Attempts were made to repair the tanks that failed the tank tightness test. Of those tanks, two were tested three times (one passed and one failed), and three were tested twice (two passed and one failed). The five failed tanks were removed and will be replaced with tanks that meet the Environmental Protection Agency regulations of underground storage tanks. 3 refs., 1 fig., 3 tabs.

  15. Effect of tight clothes on cervical and thoracic spine muscles during shoulder abduction

    PubMed Central

    Kim, Min-hee; Yoo, Won-gyu

    2016-01-01

    [Purpose] The purpose of this study was investigated the effect of tight clothes on cervical and thoracic spine muscles activities during shoulder abduction. [Subjects and Methods] The subjects of this study were 10 healthy males. The subjects performed two shoulder abduction trials for each of two jacket-wearing conditions. The right upper, middle, and lower trapezius and serratus anterior muscles activities were measured using a surface electromyography system during right shoulder abduction. [Results] The upper and middle trapezius muscle activities during shoulder abduction were significantly increased under the tight-jacket conditions compared with the general-jacket conditions. The lower trapezius and serratus anterior muscle activities were significantly decreased under the tight-jacket conditions compared with the general-jacket conditions. [Conclusion] The results of this study suggest that normal scapular movements did not occur sufficiently when wearing a tight jacket. PMID:27313348

  16. Persistent tight hamstrings following conservative treatment for apophyseal ring fracture in adolescent athletes: critical appraisal.

    PubMed

    Miyagi, Ryo; Sairyo, Koichi; Sakai, Toshinori; Tezuka, Fumitake; Kitagawa, Yasuhiro; Dezawa, Akira

    2014-01-01

    Apophyseal ring fracture is a unique disease in children and adolescents. Its clinical features include low back pain, sciatica, paravertebral muscle spasm and tenderness, restricted back motion, neurological symptoms, and tight hamstrings. For all athletes, body flexibility is one of the most important factors for better performance. Therefore, persistent tight hamstrings has a negative influence on athletic performance. In this report, we present two adolescent athletes with apophyseal ring fracture treated successfully by conservative treatment for severe low back pain (LBP) and leg pain, despite having persistent tight hamstrings for more than one year. Unlike herniated nucleus pulposus, bony fragments in the spinal canal never disappear. Although conservative treatment can alleviate LBP and leg pain, surgical removal of fragments is considered when symptoms such as tight hamstrings and restricted lumbar motion due to canal stenosis are found, particularly in athletes. PMID:25264071

  17. Tight junction disruption: Helicobacter pylori and dysregulation of the gastric mucosal barrier

    PubMed Central

    Caron, Tyler J; Scott, Kathleen E; Fox, James G; Hagen, Susan J

    2015-01-01

    Long-term chronic infection with Helicobacter pylori (H. pylori) is a risk factor for gastric cancer development. In the multi-step process that leads to gastric cancer, tight junction dysfunction is thought to occur and serve as a risk factor by permitting the permeation of luminal contents across an otherwise tight mucosa. Mechanisms that regulate tight junction function and structure in the normal stomach, or dysfunction in the infected stomach, however, are largely unknown. Although conventional tight junction components are expressed in gastric epithelial cells, claudins regulate paracellular permeability and are likely the target of inflammation or H. pylori itself. There are 27 different claudin molecules, each with unique properties that render the mucosa an intact barrier that is permselective in a way that is consistent with cell physiology. Understanding the architecture of tight junctions in the normal stomach and then changes that occur during infection is important but challenging, because most of the reports that catalog claudin expression in gastric cancer pathogenesis are contradictory. Furthermore, the role of H. pylori virulence factors, such as cytotoxin-associated gene A and vacoulating cytotoxin, in regulating tight junction dysfunction during infection is inconsistent in different gastric cell lines and in vivo, likely because non-gastric epithelial cell cultures were initially used to unravel the details of their effects on the stomach. Hampering further study, as well, is the relative lack of cultured cell models that have tight junction claudins that are consistent with native tissues. This summary will review the current state of knowledge about gastric tight junctions, normally and in H. pylori infection, and make predictions about the consequences of claudin reorganization during H. pylori infection. PMID:26523106

  18. Exploring tight junction alteration using double fluorescent probe combination of lanthanide complex with gold nanoclusters

    PubMed Central

    Wang, Xinyi; Wang, Na; Yuan, Lan; Li, Na; Wang, Junxia; Yang, Xiaoda

    2016-01-01

    Tight junctions play a key role in restricting or regulating passage of liquids, ions and large solutes through various biological barriers by the paracellular route. Changes in paracellular permeation indicate alteration of the tight junction. However, it is very difficult to obtain the structural change information by measuring paracellular flux based on transepithelial electrical resistance or using fluorescein-labeled dextrans. Here we show that the BSA and GSH stabilized gold nanoclusters exhibit marginal cytotoxicity and pass through the MDCK monolayer exclusively through the paracellular pathway. We propose a double fluorescence probe strategy, the combination of a proven paracellular indicator (europium complex) with fluorescent gold nanoclusters. We calculate changes of structural parameters in tight junctions based on determination of the diffusion coefficients of the probes. Two different types of tight junction openers are used to validate our strategy. Results show that EDTA disrupts tight junction structures and induces large and smooth paracellular pore paths with an average radius of 17 nm, but vanadyl complexes induce paths with the radius of 6 nm. The work suggests that the double fluorescence probe strategy is a useful and convenient approach for in vitro investigation of tight junction structural alternations caused by pharmacological or pathological events. PMID:27574102

  19. Exploring tight junction alteration using double fluorescent probe combination of lanthanide complex with gold nanoclusters.

    PubMed

    Wang, Xinyi; Wang, Na; Yuan, Lan; Li, Na; Wang, Junxia; Yang, Xiaoda

    2016-01-01

    Tight junctions play a key role in restricting or regulating passage of liquids, ions and large solutes through various biological barriers by the paracellular route. Changes in paracellular permeation indicate alteration of the tight junction. However, it is very difficult to obtain the structural change information by measuring paracellular flux based on transepithelial electrical resistance or using fluorescein-labeled dextrans. Here we show that the BSA and GSH stabilized gold nanoclusters exhibit marginal cytotoxicity and pass through the MDCK monolayer exclusively through the paracellular pathway. We propose a double fluorescence probe strategy, the combination of a proven paracellular indicator (europium complex) with fluorescent gold nanoclusters. We calculate changes of structural parameters in tight junctions based on determination of the diffusion coefficients of the probes. Two different types of tight junction openers are used to validate our strategy. Results show that EDTA disrupts tight junction structures and induces large and smooth paracellular pore paths with an average radius of 17 nm, but vanadyl complexes induce paths with the radius of 6 nm. The work suggests that the double fluorescence probe strategy is a useful and convenient approach for in vitro investigation of tight junction structural alternations caused by pharmacological or pathological events. PMID:27574102

  20. Junctional Adhesion Molecule A Promotes Epithelial Tight Junction Assembly to Augment Lung Barrier Function

    PubMed Central

    Mitchell, Leslie A.; Ward, Christina; Kwon, Mike; Mitchell, Patrick O.; Quintero, David A.; Nusrat, Asma; Parkos, Charles A.; Koval, Michael

    2016-01-01

    Epithelial barrier function is maintained by tight junction proteins that control paracellular fluid flux. Among these proteins is junctional adhesion molecule A (JAM-A), an Ig fold transmembrane protein. To assess JAM-A function in the lung, we depleted JAM-A in primary alveolar epithelial cells using shRNA. In cultured cells, loss of JAM-A caused an approximately 30% decrease in transepithelial resistance, decreased expression of the tight junction scaffold protein zonula occludens 1, and disrupted junctional localization of the structural transmembrane protein claudin-18. Consistent with findings in other organs, loss of JAM-A decreased β1 integrin expression and impaired filamentous actin formation. Using a model of mild systemic endoxotemia induced by i.p. injection of lipopolysaccharide, we report that JAM-A−/− mice showed increased susceptibility to pulmonary edema. On injury, the enhanced susceptibility of JAM-A−/− mice to edema correlated with increased, transient disruption of claudin-18, zonula occludens 1, and zonula occludens 2 localization to lung tight junctions in situ along with a delay in up-regulation of claudin-4. In contrast, wild-type mice showed no change in lung tight junction morphologic features in response to mild systemic endotoxemia. These findings support a key role of JAM-A in promoting tight junction homeostasis and lung barrier function by coordinating interactions among claudins, the tight junction scaffold, and the cytoskeleton. PMID:25438062

  1. Performance Improvement of Receivers Based on Ultra-Tight Integration in GNSS-Challenged Environments

    PubMed Central

    Qin, Feng; Zhan, Xingqun; Du, Gang

    2013-01-01

    Ultra-tight integration was first proposed by Abbott in 2003 with the purpose of integrating a global navigation satellite system (GNSS) and an inertial navigation system (INS). This technology can improve the tracking performances of a receiver by reconfiguring the tracking loops in GNSS-challenged environments. In this paper, the models of all error sources known to date in the phase lock loops (PLLs) of a standard receiver and an ultra-tightly integrated GNSS/INS receiver are built, respectively. Based on these models, the tracking performances of the two receivers are compared to verify the improvement due to the ultra-tight integration. Meanwhile, the PLL error distributions of the two receivers are also depicted to analyze the error changes of the tracking loops. These results show that the tracking error is significantly reduced in the ultra-tightly integrated GNSS/INS receiver since the receiver's dynamics are estimated and compensated by an INS. Moreover, the mathematical relationship between the tracking performances of the ultra-tightly integrated GNSS/INS receiver and the quality of the selected inertial measurement unit (IMU) is derived from the error models and proved by the error comparisons of four ultra-tightly integrated GNSS/INS receivers aided by different grade IMUs.

  2. Precision Polarimetry for Cold Neutrons

    NASA Astrophysics Data System (ADS)

    Barron-Palos, Libertad; Bowman, J. David; Chupp, Timothy E.; Crawford, Christopher; Danagoulian, Areg; Gentile, Thomas R.; Jones, Gordon; Klein, Andreas; Penttila, Seppo I.; Salas-Bacci, Americo; Sharma, Monisha; Wilburn, W. Scott

    2007-10-01

    The abBA and PANDA experiments, currently under development, aim to measure the correlation coefficients in the polarized free neutron beta decay at the FnPB in SNS. The polarization of the neutron beam, polarized with a ^3He spin filter, has to be known with high precision in order to achieve the goal accuracy of these experiments. In the NPDGamma experiment, where a ^3He spin filter was used, it was observed that backgrounds play an important role in the precision to which the polarization can be determined. An experiment that focuses in the reduction of background sources to establish techniques and find the upper limit for the polarization accuracy with these spin filters is currently in progress at LANSCE. A description of the measurement and results will be presented.

  3. Environment-Assisted Precision Measurement

    SciTech Connect

    Goldstein, G.; Maze, J. R.; Lukin, M. D.; Cappellaro, P.; Hodges, J. S.; Jiang, L.; Soerensen, A. S.

    2011-04-08

    We describe a method to enhance the sensitivity of precision measurements that takes advantage of the environment of a quantum sensor to amplify the response of the sensor to weak external perturbations. An individual qubit is used to sense the dynamics of surrounding ancillary qubits, which are in turn affected by the external field to be measured. The resulting sensitivity enhancement is determined by the number of ancillas that are coupled strongly to the sensor qubit; it does not depend on the exact values of the coupling strengths and is resilient to many forms of decoherence. The method achieves nearly Heisenberg-limited precision measurement, using a novel class of entangled states. We discuss specific applications to improve clock sensitivity using trapped ions and magnetic sensing based on electronic spins in diamond.

  4. Environment-assisted precision measurement.

    PubMed

    Goldstein, G; Cappellaro, P; Maze, J R; Hodges, J S; Jiang, L; Sørensen, A S; Lukin, M D

    2011-04-01

    We describe a method to enhance the sensitivity of precision measurements that takes advantage of the environment of a quantum sensor to amplify the response of the sensor to weak external perturbations. An individual qubit is used to sense the dynamics of surrounding ancillary qubits, which are in turn affected by the external field to be measured. The resulting sensitivity enhancement is determined by the number of ancillas that are coupled strongly to the sensor qubit; it does not depend on the exact values of the coupling strengths and is resilient to many forms of decoherence. The method achieves nearly Heisenberg-limited precision measurement, using a novel class of entangled states. We discuss specific applications to improve clock sensitivity using trapped ions and magnetic sensing based on electronic spins in diamond. PMID:21561175

  5. High Precision CCD Imaging Polarimetry

    NASA Astrophysics Data System (ADS)

    Magalhaes, A. M.; Rodrigues, C. V.; Margoniner, V. E.; Pereyra, A.; Heathcote, S.; Coyne, G. V.

    1994-12-01

    We describe a recent modification to the direct CCD Cameras at CTIO and LNA (Brazil) observatories in order to allow for high precision optical polarimetry. We make use of a rotating achromatic half-wave plate as a retarder and a Savart plate as analyser. Cancellation of sky polarization and independence of the CCD flat field correction are among the advantages of the arrangement. We show preliminary data that indicate the high polarimetric precision achievable with the method for non-extended sources. We give a brief description of the on-going observational programs employing the technique. Polarimetry of extended objects can be performed by using a Polaroid sheet in place of the Savart plate. Use of the Savart plate with such fields can also be valuable in the reduction, and analysis, of the extended source images as it provides polarization data on the non-extended objects in the field.

  6. Green Solvents for Precision Cleaning

    NASA Technical Reports Server (NTRS)

    Grandelli, Heather; Maloney, Phillip; DeVor, Robert; Surma, Jan; Hintze, Paul

    2013-01-01

    Aerospace machinery used in liquid oxygen (LOX) fuel systems must be precision cleaned to achieve a very low level of non-volatile residue (< 1 mg0.1 m2), especially flammable residue. Traditionally chlorofluorocarbons (CFCs) have been used in the precision cleaning of LOX systems, specifically CFC 113 (C2Cl3F3). CFCs have been known to cause the depletion of ozone and in 1987, were banned by the Montreal Protocol due to health, safety and environmental concerns. This has now led to the development of new processes in the precision cleaning of aerospace components. An ideal solvent-replacement is non-flammable, environmentally benign, non-corrosive, inexpensive, effective and evaporates completely, leaving no residue. Highlighted is a green precision cleaning process, which is contaminant removal using supercritical carbon dioxide as the environmentally benign solvent. In this process, the contaminant is dissolved in carbon dioxide, and the parts are recovered at the end of the cleaning process completely dry and ready for use. Typical contaminants of aerospace components include hydrocarbon greases, hydraulic fluids, silicone fluids and greases, fluorocarbon fluids and greases and fingerprint oil. Metallic aerospace components range from small nuts and bolts to much larger parts, such as butterfly valves 18 in diameter. A fluorinated grease, Krytox, is investigated as a model contaminant in these preliminary studies, and aluminum coupons are employed as a model aerospace component. Preliminary studies are presented in which the experimental parameters are optimized for removal of Krytox from aluminum coupons in a stirred-batch process. The experimental conditions investigated are temperature, pressure, exposure time and impeller speed. Temperatures of 308 - 423 K, pressures in the range of 8.3 - 41.4 MPa, exposure times between 5 - 60 min and impeller speeds of 0 - 1000 rpm were investigated. Preliminary results showed up to 86 cleaning efficiency with the

  7. Precision linear ramp function generator

    DOEpatents

    Jatko, W. Bruce; McNeilly, David R.; Thacker, Louis H.

    1986-01-01

    A ramp function generator is provided which produces a precise linear ramp unction which is repeatable and highly stable. A derivative feedback loop is used to stabilize the output of an integrator in the forward loop and control the ramp rate. The ramp may be started from a selected baseline voltage level and the desired ramp rate is selected by applying an appropriate constant voltage to the input of the integrator.

  8. Precision linear ramp function generator

    DOEpatents

    Jatko, W.B.; McNeilly, D.R.; Thacker, L.H.

    1984-08-01

    A ramp function generator is provided which produces a precise linear ramp function which is repeatable and highly stable. A derivative feedback loop is used to stabilize the output of an integrator in the forward loop and control the ramp rate. The ramp may be started from a selected baseline voltage level and the desired ramp rate is selected by applying an appropriate constant voltage to the input of the integrator.

  9. High precision triangular waveform generator

    DOEpatents

    Mueller, Theodore R.

    1983-01-01

    An ultra-linear ramp generator having separately programmable ascending and descending ramp rates and voltages is provided. Two constant current sources provide the ramp through an integrator. Switching of the current at current source inputs rather than at the integrator input eliminates switching transients and contributes to the waveform precision. The triangular waveforms produced by the waveform generator are characterized by accurate reproduction and low drift over periods of several hours. The ascending and descending slopes are independently selectable.

  10. Method for grinding precision components

    DOEpatents

    Ramanath, Srinivasan; Kuo, Shih Yee; Williston, William H.; Buljan, Sergej-Tomislav

    2000-01-01

    A method for precision cylindrical grinding of hard brittle materials, such as ceramics or glass and composites comprising ceramics or glass, provides material removal rates as high as 19-380 cm.sup.3 /min/cm. The abrasive tools used in the method comprise a strong, light weight wheel core bonded to a continuous rim of abrasive segments containing superabrasive grain in a dense metal bond matrix.

  11. Precision optical metrology without lasers

    NASA Astrophysics Data System (ADS)

    Bergmann, Ralf B.; Burke, Jan; Falldorf, Claas

    2015-07-01

    Optical metrology is a key technique when it comes to precise and fast measurement with a resolution down to the micrometer or even nanometer regime. The choice of a particular optical metrology technique and the quality of results depends on sample parameters such as size, geometry and surface roughness as well as user requirements such as resolution, measurement time and robustness. Interferometry-based techniques are well known for their low measurement uncertainty in the nm range, but usually require careful isolation against vibration and a laser source that often needs shielding for reasons of eye-safety. In this paper, we concentrate on high precision optical metrology without lasers by using the gradient based measurement technique of deflectometry and the finite difference based technique of shear interferometry. Careful calibration of deflectometry systems allows one to investigate virtually all kinds of reflecting surfaces including aspheres or free-form surfaces with measurement uncertainties below the μm level. Computational Shear Interferometry (CoSI) allows us to combine interferometric accuracy and the possibility to use cheap and eye-safe low-brilliance light sources such as e.g. fiber coupled LEDs or even liquid crystal displays. We use CoSI e.g. for quantitative phase contrast imaging in microscopy. We highlight the advantages of both methods, discuss their transfer functions and present results on the precision of both techniques.

  12. Development and testing of an ion probe for tightly-bunched particle beams

    SciTech Connect

    Ngo, M.; Pasour, J.

    1996-06-01

    Many high-energy physics experiments require a high-quality and well-diagnosed charged-particle beam (CPB). Precise knowledge of beam size, position, and charge distribution is often crucial to the success of the experiment. It is also important in many applications that the diagnostic used to determine the beam parameters be nonintercepting and nonperturbing. This requirement rules out many diagnostics, such as wire scanners, thin foils which produce Cerenkov or transition radiation, and even some rf cavity diagnostics. Particularly difficult to diagnose are tightly-focused (r{sub b} << 1 mm), short-duration (psec) beams, such as those in state-of-the-art or next-generation particle colliders. In this paper we describe an ion probe that is capable of penetrating the space-charge field of densely bunched CPBs without perturbation, thereby enabling the measurement of the microstructure of the bunch. This diagnostic probe uses a finely-focused stream of ions to interact with the CPB. Related techniques have been discussed in the literature. In fact, the present work evolved from an electron deflection diagnostic for CPBs that we previously described. A similar electron probe was tested even earlier at TRIUMF and in the Former Soviet Union. Electron probes have also been used to measure plasma sheaths and potentials and the neutralization of heavy ion beams. Also, Mendel has used an ion beam (22 keV He{sup +}) to probe rapidly varying fields in plasmas. The probe ions are injected across the beam tube and into the path of the high-energy CPB. The ions are deflected by the CPB, and the direction and magnitude of the deflection are directly related to the spatial and temporal charge distribution of the CPB. Easily-resolved deflections can be produced by microbunches having total charge on the order of a nCoul and pulse durations of a few psec. The deflected ions are monitored with a suitable detector, in this case a microchannel plate capable of detecting single ions.

  13. What can we learn from ultrasonic velocities monitoring during hydraulic fracturing of tight shale ?

    NASA Astrophysics Data System (ADS)

    Fortin, Jérôme; Stanchits, Sergei

    2016-04-01

    Methods of prediction the size and aperture of created hydraulic fracture are essential for a proper design of unconventional reservoir well stimulation. Several theoretical models describing hydraulic fracture propagation have been developed. However, there is a lack of direct field measurements of hydraulic fracture dimensions, verifying results of these models. Monitoring of elastic wave parameters may be a useful tool to estimate fracture dimensions. Indeed, the elastic wave velocity in a medium containing a fracture is sensitive to the fracture geometry and its conditions: dry fracture or saturated with fluid. In this paper, we focus on ultrasonic velocities monitoring during hydraulic fracturing of tight shale. We report the results of hydraulic fracturing of Niobrara shale outcrop block of 279 x 279 x 381 mm size from Colorado, USA. In this experiment, the block was loaded in a polyaxial loading frame made by TerraTek, a Schlumberger Company. Stresses were applied to the rock blocks independently in three directions using flat jacks. Then viscous fluid was injected into borehole at a constant flow rate. 20 PZT sensors were embedded into pockets drilled in the rock. They were used for registration of Acoustic Emission (AE) signals and for periodical ultrasonic transmissions to measure P-wave velocities in different directions. Our results show that ultrasonic measurements can be useful for understanding the mechanics of the crack growth. More precisely, from the evolution of the P-velocities and their amplitudes during the loading, we are able: (i) to estimate the velocity of the hydraulic fracture which was found to be 0.15 mm/s (that is close to the fracture velocity inferred from the dynamic of AE spatial evolution). (ii) In addition, the evolution of the P-velocities during the loading shows that a liquid-free crack always precedes the liquid front. In our experiment, the lag is estimated to be 15 mm. (iii) Finally, at fixed distances from the borehole

  14. Precision ozone vapor pressure measurements

    NASA Technical Reports Server (NTRS)

    Hanson, D.; Mauersberger, K.

    1985-01-01

    The vapor pressure above liquid ozone has been measured with a high accuracy over a temperature range of 85 to 95 K. At the boiling point of liquid argon (87.3 K) an ozone vapor pressure of 0.0403 Torr was obtained with an accuracy of + or - 0.7 percent. A least square fit of the data provided the Clausius-Clapeyron equation for liquid ozone; a latent heat of 82.7 cal/g was calculated. High-precision vapor pressure data are expected to aid research in atmospheric ozone measurements and in many laboratory ozone studies such as measurements of cross sections and reaction rates.

  15. Axion Bounds from Precision Cosmology

    SciTech Connect

    Raffelt, G. G.; Hamann, J.; Hannestad, S.; Mirizzi, A.; Wong, Y. Y. Y.

    2010-08-30

    Depending on their mass, axions produced in the early universe can leave different imprints in cosmic structures. If axions have masses in the eV-range, they contribute a hot dark matter fraction, allowing one to constrain m{sub a} in analogy to neutrinos. In the more favored scenario where axions play the role of cold dark matter and if reheating after inflation does not restore the Peccei-Quinn symmetry, the axion field provides isocurvature fluctuations that are severely constrained by precision cosmology. There remains a small sliver in parameter space where isocurvature fluctuations could still show up in future probes.

  16. An Arbitrary Precision Computation Package

    Energy Science and Technology Software Center (ESTSC)

    2003-06-14

    This package permits a scientist to perform computations using an arbitrarily high level of numeric precision (the equivalent of hundreds or even thousands of digits), by making only minor changes to conventional C++ or Fortran-90 soruce code. This software takes advantage of certain properties of IEEE floating-point arithmetic, together with advanced numeric algorithms, custom data types and operator overloading. Also included in this package is the "Experimental Mathematician's Toolkit", which incorporates many of these facilitiesmore » into an easy-to-use interactive program.« less

  17. The Magsat precision vector magnetometer

    NASA Technical Reports Server (NTRS)

    Acuna, M. H.

    1980-01-01

    This paper examines the Magsat precision vector magnetometer which is designed to measure projections of the ambient field in three orthogonal directions. The system contains a highly stable and linear triaxial fluxgate magnetometer with a dynamic range of + or - 2000 nT (1 nT = 10 to the -9 weber per sq m). The magnetometer electronics, analog-to-digital converter, and digitally controlled current sources are implemented with redundant designs to avoid a loss of data in case of failures. Measurements are carried out with an accuracy of + or - 1 part in 64,000 in magnitude and 5 arcsec in orientation (1 arcsec = 0.00028 deg).

  18. Precision Measurement Of Corneal Topography

    NASA Astrophysics Data System (ADS)

    Yoder, Paul R.; Macri, Timothy F.; Telfair, William B.; Bennett, Peter S.; Martin, Clifford A.; Warner, John W.

    1989-05-01

    We describe a new electro-optical device being developed to provide precise measurements of the three-dimensional topography of the human cornea. This device, called a digital keratoscope, is intended primarily for use in preparing for and determining the effect of corneal surgery procedures such as laser refractive keratectomy, radial keratotomy or corneal transplant on the refractive power of the cornea. It also may serve as an aid in prescribing contact lenses. The basic design features of the hardware and of the associated computer software are discussed, the means for alignment and calibration are described and typical results are given.

  19. Precision Drilling Of Sugar Beet

    NASA Astrophysics Data System (ADS)

    Kalina, Jaroslav

    1983-03-01

    The paper describes the features of the precision drilling of sugar beet, methods of measurements, mathematical relations, procedure and results. The use of a high-speed camera and of a computer with an investigation of the drilling mechanisms enabled to achieve the shortening of the procedure by one half, an accurate assessment of the principles of drilling mechanisms without implication of other influences arising in field tests and the availability of more data for decision making. The result of the experiments was a considerably simpler assessment of the principles of drill mechanisms.

  20. Constraining supersymmetry with precision data

    SciTech Connect

    Pierce, Damien M.; Erler, Jens

    1997-06-15

    We discuss the results of a global fit to precision data in supersymmetric models. We consider both gravity- and gauge-mediated models. As the superpartner spectrum becomes light, the global fit to the data typically results in larger values of {chi}{sup 2}. We indicate the regions of parameter space which are excluded by the data. We discuss the additional effect of the B(B{yields}X{sub s}{gamma}) measurement. Our analysis excludes chargino masses below M{sub Z} in the simplest gauge-mediated model with {mu}>0, with stronger constraints for larger values of tan {beta}.

  1. Production of Natural Gas and Fluid Flow in Tight Sand Reservoirs

    SciTech Connect

    Maria Cecilia Bravo

    2006-06-30

    This document reports progress of this research effort in identifying relationships and defining dependencies between macroscopic reservoir parameters strongly affected by microscopic flow dynamics and production well performance in tight gas sand reservoirs. These dependencies are investigated by identifying the main transport mechanisms at the pore scale that should affect fluids flow at the reservoir scale. A critical review of commercial reservoir simulators, used to predict tight sand gas reservoir, revealed that many are poor when used to model fluid flow through tight reservoirs. Conventional simulators ignore altogether or model incorrectly certain phenomena such as, Knudsen diffusion, electro-kinetic effects, ordinary diffusion mechanisms and water vaporization. We studied the effect of Knudsen's number in Klinkenberg's equation and evaluated the effect of different flow regimes on Klinkenberg's parameter b. We developed a model capable of explaining the pressure dependence of this parameter that has been experimentally observed, but not explained in the conventional formalisms. We demonstrated the relevance of this, so far ignored effect, in tight sands reservoir modeling. A 2-D numerical simulator based on equations that capture the above mentioned phenomena was developed. Dynamic implications of new equations are comprehensively discussed in our work and their relative contribution to the flow rate is evaluated. We performed several simulation sensitivity studies that evidenced that, in general terms, our formalism should be implemented in order to get more reliable tight sands gas reservoirs' predictions.

  2. RAGE mediated intracellular Aβ uptake contributes to the breakdown of tight junction in retinal pigment epithelium

    PubMed Central

    Park, Sung Wook; Kim, Jin Hyoung; Park, Sang Min; Moon, Minho; Lee, Kihwang; Park, Kyu Hyung; Park, Woo Jin; Kim, Jeong Hun

    2015-01-01

    Intracellular amyloid beta (Aβ) has been implicated in neuronal cell death in Alzheimer's disease (AD). Intracellular Aβ also contributes to tight junction breakdown of retinal pigment epithelium (RPE) in age-related macular degeneration (AMD). Although Aβ is predominantly secreted from neuronal cells, the mechanism of Aβ transport into RPE remains to be fully elucidated. In this study, we demonstrated that intracellular Aβ was found concomitantly with the breakdown of tight junction in RPE after subretinal injection of Aβ into the mouse eye. We also presented evidence that receptor for advanced glycation end products (RAGE) contributed to endocytosis of Aβ in RPE. siRNA-mediated knockdown of RAGE prevented intracellular Aβ accumulation as well as subsequent tight junction breakdown in RPE. In addition, we found that RAGE-mediated p38 MAPK signaling contributed to endocytosis of Aβ. Blockade of RAGE/p38 MAPK signaling inhibited Aβ endocytosis, thereby preventing tight junction breakdown in RPE. These results implicate that intracellular Aβ contributes to the breakdown of tight junction in RPE via the RAGE/p38 MAPK-mediated endocytosis. Thus, we suggest that RAGE could be a potential therapeutic target for intracellular Aβ induced outer BRB breakdown in AMD. PMID:26431165

  3. Chitosan encapsulation modulates the effect of capsaicin on the tight junctions of MDCK cells

    PubMed Central

    Kaiser, M.; Pereira, S.; Pohl, L.; Ketelhut, S.; Kemper, B.; Gorzelanny, C.; Galla, H. -J.; Moerschbacher, B. M.; Goycoolea, F. M.

    2015-01-01

    Capsaicin has known pharmacological effects including the ability to reversibly open cellular tight junctions, among others. The aim of this study was to develop a strategy to enhance the paracellular transport of a substance with low permeability (FITC-dextran) across an epithelial cell monolayer via reversible opening of cellular tight junctions using a nanosystem comprised by capsaicin and of chitosan. We compared the biophysical properties of free capsaicin and capsaicin-loaded chitosan nanocapsules, including their cytotoxicity towards epithelial MDCK-C7 cells and their effect on the integrity of tight junctions, membrane permeability and cellular uptake. The cytotoxic response of MDCK-C7 cells to capsaicin at a concentration of 500 μM, which was evident for the free compound, is not observable following its encapsulation. The interaction between nanocapsules and the tight junctions of MDCK-C7 cells was investigated by impedance spectroscopy, digital holographic microscopy and structured illumination fluorescence microscopy. The nanocapsules modulated the interaction between capsaicin and tight junctions as shown by the different time profile of trans-epithelial electrical resistance and the enhanced permeability of monolayers incubated with FITC-dextran. Structured illumination fluorescence microscopy showed that the nanocapsules were internalized by MDCK-C7 cells. The capsaicin-loaded nanocapsules could be further developed as drug nanocarriers with enhanced epithelial permeability. PMID:25970096

  4. Chitosan encapsulation modulates the effect of capsaicin on the tight junctions of MDCK cells.

    PubMed

    Kaiser, M; Pereira, S; Pohl, L; Ketelhut, S; Kemper, B; Gorzelanny, C; Galla, H-J; Moerschbacher, B M; Goycoolea, F M

    2015-01-01

    Capsaicin has known pharmacological effects including the ability to reversibly open cellular tight junctions, among others. The aim of this study was to develop a strategy to enhance the paracellular transport of a substance with low permeability (FITC-dextran) across an epithelial cell monolayer via reversible opening of cellular tight junctions using a nanosystem comprised by capsaicin and of chitosan. We compared the biophysical properties of free capsaicin and capsaicin-loaded chitosan nanocapsules, including their cytotoxicity towards epithelial MDCK-C7 cells and their effect on the integrity of tight junctions, membrane permeability and cellular uptake. The cytotoxic response of MDCK-C7 cells to capsaicin at a concentration of 500 μM, which was evident for the free compound, is not observable following its encapsulation. The interaction between nanocapsules and the tight junctions of MDCK-C7 cells was investigated by impedance spectroscopy, digital holographic microscopy and structured illumination fluorescence microscopy. The nanocapsules modulated the interaction between capsaicin and tight junctions as shown by the different time profile of trans-epithelial electrical resistance and the enhanced permeability of monolayers incubated with FITC-dextran. Structured illumination fluorescence microscopy showed that the nanocapsules were internalized by MDCK-C7 cells. The capsaicin-loaded nanocapsules could be further developed as drug nanocarriers with enhanced epithelial permeability. PMID:25970096

  5. Superallowed nuclear beta decay: Precision measurements for basic physics

    SciTech Connect

    Hardy, J. C.

    2012-11-20

    For 60 years, superallowed 0{sup +}{yields}0{sup +} nuclear beta decay has been used to probe the weak interaction, currently verifying the conservation of the vector current (CVC) to high precision ({+-}0.01%) and anchoring the most demanding available test of the unitarity of the Cabibbo-Kobayashi-Maskawa (CKM) matrix ({+-}0.06%), a fundamental pillar of the electroweak standard model. Each superallowed transition is characterized by its ft-value, a result obtained from three measured quantities: the total decay energy of the transition, its branching ratio, and the half-life of the parent state. Today's data set is composed of some 150 independent measurements of 13 separate superallowed transitions covering a wide range of parent nuclei from {sup 10}C to {sup 74}Rb. Excellent consistency among the average results for all 13 transitions - a prediction of CVC - also confirms the validity of the small transition-dependent theoretical corrections that have been applied to account for isospin symmetry breaking. With CVC consistency established, the value of the vector coupling constant, G{sub V}, has been extracted from the data and used to determine the top left element of the CKM matrix, V{sub ud}. With this result the top-row unitarity test of the CKM matrix yields the value 0.99995(61), a result that sets a tight limit on possible new physics beyond the standard model. To have any impact on these fundamental weak-interaction tests, any measurement must be made with a precision of 0.1% or better - a substantial experimental challenge well beyond the requirements of most nuclear physics measurements. I overview the current state of the field and outline some of the requirements that need to be met by experimentalists if they aim to make measurements with this high level of precision.

  6. Precision Measurements in 37K

    NASA Astrophysics Data System (ADS)

    Anholm, Melissa; Ashery, Daniel; Behling, Spencer; Fenker, Benjamin; Melconian, Dan; Mehlman, Michael; Behr, John; Gorelov, Alexandre; Olchanski, Konstantin; Preston, Claire; Warner, Claire; Gwinner, Gerald

    2015-10-01

    We have performed precision measurements of the kinematics of the daughter particles in the decay of 37K. This isotope decays by β+ emission in a mixed Fermi/Gamow-Teller transition to its isobaric analog, 37Ar. Because the higher-order standard model corrections to this decay process are well understood, it is an ideal candidate for for improving constraints on interactions beyond the standard model. Our setup utilizes a magneto-optical trap to confine and cool samples of 37K, which are then spin-polarized by optical pumping. This allows us to perform measurements on both polarized and unpolarized nuclei, which is valuable for a complete understanding of systematic effects. Precision measurements of this decay are expected to be sensitive to the presence of right-handed vector currents, as well as a linear combination of scalar and tensor currents. Progress towards a final result is presented here. Support provided by: NSERC, NRC through TRIUMF, DOE ER40773, Early Career ER41747, Israel Science Foundation.

  7. Precision Environmental Radiation Monitoring System

    SciTech Connect

    Vladimir Popov, Pavel Degtiarenko

    2010-07-01

    A new precision low-level environmental radiation monitoring system has been developed and tested at Jefferson Lab. This system provides environmental radiation measurements with accuracy and stability of the order of 1 nGy/h in an hour, roughly corresponding to approximately 1% of the natural cosmic background at the sea level. Advanced electronic front-end has been designed and produced for use with the industry-standard High Pressure Ionization Chamber detector hardware. A new highly sensitive readout electronic circuit was designed to measure charge from the virtually suspended ionization chamber ion collecting electrode. New signal processing technique and dedicated data acquisition were tested together with the new readout. The designed system enabled data collection in a remote Linux-operated computer workstation, which was connected to the detectors using a standard telephone cable line. The data acquisition system algorithm is built around the continuously running 24-bit resolution 192 kHz data sampling analog to digital convertor. The major features of the design include: extremely low leakage current in the input circuit, true charge integrating mode operation, and relatively fast response to the intermediate radiation change. These features allow operating of the device as an environmental radiation monitor, at the perimeters of the radiation-generating installations in densely populated areas, like in other monitoring and security applications requiring high precision and long-term stability. Initial system evaluation results are presented.

  8. Precision experiments in electroweak interactions

    SciTech Connect

    Swartz, M.L.

    1990-03-01

    The electroweak theory of Glashow, Weinberg, and Salam (GWS) has become one of the twin pillars upon which our understanding of all particle physics phenomena rests. It is a brilliant achievement that qualitatively and quantitatively describes all of the vast quantity of experimental data that have been accumulated over some forty years. Note that the word quantitatively must be qualified. The low energy limiting cases of the GWS theory, Quantum Electrodynamics and the V-A Theory of Weak Interactions, have withstood rigorous testing. The high energy synthesis of these ideas, the GWS theory, has not yet been subjected to comparably precise scrutiny. The recent operation of a new generation of proton-antiproton (p{bar p}) and electron-positron (e{sup +}e{sup {minus}}) colliders has made it possible to produce and study large samples of the electroweak gauge bosons W{sup {plus minus}} and Z{sup 0}. We expect that these facilities will enable very precise tests of the GWS theory to be performed in the near future. In keeping with the theme of this Institute, Physics at the 100 GeV Mass Scale, these lectures will explore the current status and the near-future prospects of these experiments.

  9. Low f-number photoacoustic lens for tight ultrasonic focusing and free-field micro-cavitation in water

    NASA Astrophysics Data System (ADS)

    Lee, Taehwa; Ok, Jong G.; Guo, L. Jay; Baac, Hyoung Won

    2016-03-01

    We demonstrate a photoacoustic lens with a low f-number of 0.61 and a high focal gain of 220 at 15-MHz frequency for laser-generated focused ultrasound (LGFU), which enables free-field micro-cavitation in water. Due to tight ultrasonic focusing (90 μm in lateral and 200 μm in longitudinal spot widths at a distance of 9.2 mm), the lens produces a peak pressure of 20 MPa (positive) using an input laser energy of only 1 mJ/pulse (6-ns temporal width). Remarkably, we confirm single-pulsed micro-cavitation in a free-field condition by using this lens, which has not previously been achieved with LGFU. The free-field cavitation was monitored and characterized in terms of a bubble radius, a lifetime, and a probability. Our result demonstrates that LGFU amplitudes can be sufficiently higher than a threshold for free-field cavitation at a microscale spot, which is a crucial step for cavitation-based therapy with high precision.

  10. Destruction of attractive bosonic cloud due to high spatial coherence in tight trap

    SciTech Connect

    Biswas, Anindya; Das, Tapan Kumar; Chakrabarti, Barnali

    2011-10-15

    We study coherence of a trapped bosonic cloud with attractive finite-range interaction in a tight harmonic trap. One-body density and pair-distribution function in the ground state for different trap sizes are calculated. We also calculate healing length and the correlation length which signify the presence of high spatial coherence in a very tight trap leading to the destruction of the condensate for a fixed particle number. This is in marked variance with the usual collapse of the attractive metastable condensate when N>N{sub cr}. Thus we investigate the critical frequency and critical size of the trap for the existence of attractive Bose-Einstein condensation. The finite-range interaction gives a nonlocal effect in the effective many-body potential, and we observe a high-density stable branch besides the known metastable branch. Moreover, the new branch shows universal behavior even in the very tight trap.

  11. Pressure Drop Characteristics in Tight-Lattice Bundles for Reduced-Moderation Water Reactors

    NASA Astrophysics Data System (ADS)

    Tamai, Hidesada; Kureta, Masatoshi; Yoshida, Hiroyuki; Akimoto, Hajime

    The reduced-moderation water reactor (RMWR) consists of several distinctive structures; a triangular tight-lattice configuration and a double-flat core. In order to design the RMWR core from the point of view of thermal-hydraulics, an evaluation method on pressure drop characteristics in the rod bundles at the tight-lattice configuration is required. In this study, calculated results by the Martinelli-Nelson's and Hancox's correlations were compared with experimental results in 4×5 rod bundles and seven-rod bundles. Consequently, the friction loss in two-phase flows becomes smaller at the tight-lattice configuration with the hydraulic diameter less than about 3mm. This reason is due to the difference of the configuration between the multi-rod bundle and the circular tube and due to the effect of the small hydraulic diameter on the two-phase multiplier.

  12. Rapid method of quantification of tight-junction organization using image analysis.

    PubMed

    Terryn, Christine; Sellami, Mehdi; Fichel, Caroline; Diebold, Marie-Danielle; Gangloff, Sophie; Le Naour, Richard; Polette, Myriam; Zahm, Jean-Marie

    2013-02-01

    The spatial organization of proteins in a cell population or in tissues is an important parameter to study the functionality of biological specimens. In this article, we have focused on tight junctions which form network-like features in immunofluorescence microscopy images. Usually, the organization or disorganization of tight junctions is noticed qualitatively. The aim of this article is to present a simple method to quantify the organization level of tight junction network using image analysis with a dedicated macro developed with Image J software. The method has been validated with simulated images displaying regular decrease of network organization. Then, the macro has been applied to immunofluorescence microscopy images of cells in culture and of tissue sections. PMID:23212973

  13. Structurally controlled and aligned tight gas reservoir compartmentalization in the San Juan and Piceance Basins

    SciTech Connect

    Decker, A.D.; Kuuskraa, V.A.; Klawitter, A.L.

    1995-10-01

    Recurrent basement faulting is the primary controlling mechanism for aligning and compartmentalizing upper Cretaceous aged tight gas reservoirs of the San Juan and Piceance Basins. Northwest trending structural lineaments that formed in conjunction with the Uncompahgre Highlands have profoundly influenced sedimentation trends and created boundaries for gas migration; sealing and compartmentalizing sedimentary packages in both basins. Fractures which formed over the structural lineaments provide permeability pathways which allowing gas recovery from otherwise tight gas reservoirs. Structural alignments and associated reservoir compartments have been accurately targeted by integrating advanced remote sensing imagery, high resolution aeromagnetics, seismic interpretation, stratigraphic mapping and dynamic structural modelling. This unifying methodology is a powerful tool for exploration geologists and is also a systematic approach to tight gas resource assessment in frontier basins.

  14. Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer

    PubMed Central

    Landy, Jonathan; Ronde, Emma; English, Nick; Clark, Sue K; Hart, Ailsa L; Knight, Stella C; Ciclitira, Paul J; Al-Hassi, Hafid Omar

    2016-01-01

    Inflammatory bowel diseases are characterised by inflammation that compromises the integrity of the epithelial barrier. The intestinal epithelium is not only a static barrier but has evolved complex mechanisms to control and regulate bacterial interactions with the mucosal surface. Apical tight junction proteins are critical in the maintenance of epithelial barrier function and control of paracellular permeability. The characterisation of alterations in tight junction proteins as key players in epithelial barrier function in inflammatory bowel diseases is rapidly enhancing our understanding of critical mechanisms in disease pathogenesis as well as novel therapeutic opportunities. Here we give an overview of recent literature focusing on the role of tight junction proteins, in particular claudins, in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer. PMID:27003989

  15. Tight-binding model study of topological properties in few-layer black phosphorus

    NASA Astrophysics Data System (ADS)

    Doh, Hyeonjin; Choi, Hyoung Joon

    We study the simplest tight-binding model describing the band structures of mono- and bilayer phosphorus. The band structures are analyzed for various tight-binding parameters, and the gap-closing conditions are found where the system turns into a Dirac semi-metal. We show the tight-binding model Hamiltonian can be reduced to Dirac Hamiltonian and investigate its topological properties. The doping, electric field and pressure effects on topological properties of black phosphorus are discussed and these analyses suggest directions the the control of the energy gap in these system. This work was supported by NRF of Korea (Grant No. 2011-0018306) and KISTI supercomputing center (Project No. KSC-2015-C3-039).

  16. Method Of Making A Vacuum-Tight Continuous Cable Feedthrough Device

    DOEpatents

    Bazizi, Kamel Abdel; Haelen, Thomas Eugene; Lobkowicz, Frederick; Slattery, Paul Francis

    2001-07-17

    A vacuum-tight cable feedthrough device includes a metallic first flange that is penetrated by a slot. Passing through the slot is a flat stripline cable that includes a plurality of conductive signal channels encompassed by a dielectric material on whose upper and lower surfaces is disposed a conductive material includes a ground. The stripline cable is sealed within the slot to provide a substantially vacuum-tight seal between the cable and the first flange. In a preferred embodiment, the cable feedthrough device includes a plurality, at least 16, of stripline cables. In a further preferred embodiment, the device includes a second flange and a bellows sealably connecting the first and second flanges, thereby providing a substantially vacuum-tight, flexible housing for the plurality of cables.

  17. Sequoia: A fault-tolerant tightly coupled multiprocessor for transaction processing

    SciTech Connect

    Bernstein, P.A.

    1988-02-01

    The Sequoia computer is a tightly coupled multiprocessor, and thus attains the performance advantages of this style of architecture. It avoids most of the fault-tolerance disadvantages of tight coupling by using a new fault-tolerance design. The Sequoia architecture is similar to other multimicroprocessor architectures, such as those of Encore and Sequent, in that it gives dozens of microprocessors shared access to a large main memory. It resembles the Stratus architecture in its extensive use of hardware fault-detection techniques. It resembles Stratus and Auragen in its ability to quickly recover all processes after a single point failure, transparently to the user. However, Sequoia is unique in its combination of a large-scale tightly coupled architecture with a hardware approach to fault tolerance. This article gives an overview of how the hardware architecture and operating systems (OS) work together to provide a high degree of fault tolerance with good system performance.

  18. Manufacturing Precise, Lightweight Paraboloidal Mirrors

    NASA Technical Reports Server (NTRS)

    Hermann, Frederick Thomas

    2006-01-01

    A process for fabricating a precise, diffraction- limited, ultra-lightweight, composite- material (matrix/fiber) paraboloidal telescope mirror has been devised. Unlike the traditional process of fabrication of heavier glass-based mirrors, this process involves a minimum of manual steps and subjective judgment. Instead, this process involves objectively controllable, repeatable steps; hence, this process is better suited for mass production. Other processes that have been investigated for fabrication of precise composite-material lightweight mirrors have resulted in print-through of fiber patterns onto reflecting surfaces, and have not provided adequate structural support for maintenance of stable, diffraction-limited surface figures. In contrast, this process does not result in print-through of the fiber pattern onto the reflecting surface and does provide a lightweight, rigid structure capable of maintaining a diffraction-limited surface figure in the face of changing temperature, humidity, and air pressure. The process consists mainly of the following steps: 1. A precise glass mandrel is fabricated by conventional optical grinding and polishing. 2. The mandrel is coated with a release agent and covered with layers of a carbon- fiber composite material. 3. The outer surface of the outer layer of the carbon-fiber composite material is coated with a surfactant chosen to provide for the proper flow of an epoxy resin to be applied subsequently. 4. The mandrel as thus covered is mounted on a temperature-controlled spin table. 5. The table is heated to a suitable temperature and spun at a suitable speed as the epoxy resin is poured onto the coated carbon-fiber composite material. 6. The surface figure of the optic is monitored and adjusted by use of traditional Ronchi, Focault, and interferometric optical measurement techniques while the speed of rotation and the temperature are adjusted to obtain the desired figure. The proper selection of surfactant, speed or rotation

  19. Assembling Precise Truss Structures With Minimal Stresses

    NASA Technical Reports Server (NTRS)

    Sword, Lee F.

    1996-01-01

    Improved method of assembling precise truss structures involves use of simple devices. Tapered pins that fit in tapered holes indicate deviations from prescribed lengths. Method both helps to ensure precision of finished structures and minimizes residual stresses within structures.

  20. Role of telecommunications in precision agriculture

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Precision agriculture has been made possible by the confluence of several technologies: geographic positioning systems, geographic information systems, image analysis software, low-cost microcomputer-based variable rate controller/recorders, and precision tractor guidance systems. While these techn...

  1. Using hyperspectral data in precision farming applications

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Precision farming practices such as variable rate applications of fertilizer and agricultural chemicals require accurate field variability mapping. This chapter investigated the value of hyperspectral remote sensing in providing useful information for five applications of precision farming: (a) Soil...

  2. Precise Nanoelectronics with Adatom Chains

    NASA Technical Reports Server (NTRS)

    Yamada, Toshishige

    1999-01-01

    Adatom chains on an atomically regulated substrate will be building components in future precise nanoelectronics. Adatoms need to be secured with chemical bonding, but then electronic isolation between the adatom and substrate systems is not guaranteed. A one-dimensional model shows that good isolation with existence of surface states is expected on an s-p crossing substrate such as Si, Ge, or GaAs, reflecting the bulk nature of the substrate. Isolation is better if adatoms are electronically similar to the substrate atoms, and can be manipulated by hydrogenation. Chain structures with group IV adatoms with two chemical bonds, or group III adatoms with one chemical bond, are semiconducting, reflecting the surface nature of the substrate. These structures are unintentionally doped due to the charge transfer across the chemical bonds. Physical properties of adatom chains have to be determined for the unified adatom-substrate system.

  3. Precision Spectroscopy of Atomic Hydrogen

    NASA Astrophysics Data System (ADS)

    Beyer, A.; Parthey, Ch G.; Kolachevsky, N.; Alnis, J.; Khabarova, K.; Pohl, R.; Peters, E.; Yost, D. C.; Matveev, A.; Predehl, K.; Droste, S.; Wilken, T.; Holzwarth, R.; Hänsch, T. W.; Abgrall, M.; Rovera, D.; Salomon, Ch; Laurent, Ph; Udem, Th

    2013-12-01

    Precise determinations of transition frequencies of simple atomic systems are required for a number of fundamental applications such as tests of quantum electrodynamics (QED), the determination of fundamental constants and nuclear charge radii. The sharpest transition in atomic hydrogen occurs between the metastable 2S state and the 1S ground state. Its transition frequency has now been measured with almost 15 digits accuracy using an optical frequency comb and a cesium atomic clock as a reference [1]. A recent measurement of the 2S - 2P3/2 transition frequency in muonic hydrogen is in significant contradiction to the hydrogen data if QED calculations are assumed to be correct [2, 3]. We hope to contribute to this so-called "proton size puzzle" by providing additional experimental input from hydrogen spectroscopy.

  4. False precision and population science.

    PubMed

    Weigel, G

    1994-09-01

    The author compares proponents of reducing population growth to alchemists and astrologers, thereby whole-heartedly dismissing the validity of the field of population science. His vitriolic essay argues thus: population science cannot predict the growth rate of human populations over long periods of time, population science can determine neither when nor how fertility rates will decline, only 10% of developing country populations are covered by reliable vital statistic registration systems, and population science has no scientifically precise definition of overpopulation. The images of disease, hunger, and overcrowding evoked by the notion overpopulation are instead due to poverty and material deprivation. Were delegates to the 1994 UN International Conference on Population and Development to address these real, latter issues, positive social change may result. Since conference attendees are, however, committed to a narrowly focused and flawed agenda, the world should dismiss conference policies as the nonsense that they are. PMID:12345660

  5. Navy precision optical interferometer database

    NASA Astrophysics Data System (ADS)

    Ryan, K. K.; Jorgensen, A. M.; Hall, T.; Armstrong, J. T.; Hutter, D.; Mozurkewich, D.

    2012-07-01

    The Navy Precision Optical Interferometer (NPOI) has now been recording astronomical observations for the better part of two decades. During that time period hundreds of thousands of observations have been obtained, with a total data volume of multiple terabytes. Additionally, in the next few years the data rate from the NPOI is expected to increase significantly. To make it easier for NPOI users to search the NPOI observations and to make it easier for them to obtain data, we have constructed a easily accessible and searchable database of observations. The database is based on a MySQL server and uses standard query language (SQL). In this paper we will describe the database table layout and show examples of possible database queries.

  6. Precision cosmology and the landscape

    SciTech Connect

    Bousso, Raphael; Bousso, Raphael

    2006-10-01

    After reviewing the cosmological constant problem -- why is Lambda not huge? -- I outline the two basic approaches that had emerged by the late 1980s, and note that each made a clear prediction. Precision cosmological experiments now indicate that the cosmological constant is nonzero. This result strongly favors the environmental approach, in which vacuum energy can vary discretely among widely separated regions in the universe. The need to explain this variation from first principles constitutes an observational constraint on fundamental theory. I review arguments that string theory satisfies this constraint, as it contains a dense discretuum of metastable vacua. The enormous landscape of vacua calls for novel, statistical methods of deriving predictions, and it prompts us to reexamine our description of spacetime on the largest scales. I discuss the effects of cosmological dynamics, and I speculate that weighting vacua by their entropy production may allow for prior-free predictions that do not resort to explicitly anthropic arguments.

  7. Precision moisture generation and measurement.

    SciTech Connect

    Thornberg, Steven Michael; White, Michael I.; Irwin, Adriane Nadine

    2010-03-01

    In many industrial processes, gaseous moisture is undesirable as it can lead to metal corrosion, polymer degradation, and other materials aging processes. However, generating and measuring precise moisture concentrations is challenging due to the need to cover a broad concentration range (parts-per-billion to percent) and the affinity of moisture to a wide range surfaces and materials. This document will discuss the techniques employed by the Mass Spectrometry Laboratory of the Materials Reliability Department at Sandia National Laboratories to generate and measure known gaseous moisture concentrations. This document highlights the use of a chilled mirror and primary standard humidity generator for the characterization of aluminum oxide moisture sensors. The data presented shows an excellent correlation in frost point measured between the two instruments, and thus provides an accurate and reliable platform for characterizing moisture sensors and performing other moisture related experiments.

  8. System for precise position registration

    DOEpatents

    Sundelin, Ronald M.; Wang, Tong

    2005-11-22

    An apparatus for enabling accurate retaining of a precise position, such as for reacquisition of a microscopic spot or feature having a size of 0.1 mm or less, on broad-area surfaces after non-in situ processing. The apparatus includes a sample and sample holder. The sample holder includes a base and three support posts. Two of the support posts interact with a cylindrical hole and a U-groove in the sample to establish location of one point on the sample and a line through the sample. Simultaneous contact of the third support post with the surface of the sample defines a plane through the sample. All points of the sample are therefore uniquely defined by the sample and sample holder. The position registration system of the current invention provides accuracy, as measured in x, y repeatability, of at least 140 .mu.m.

  9. High-perveance electron guns with vacuum-tight cermet bodies

    SciTech Connect

    Zinchenko, N.S.; Afanas'ev, V.I.; Khoroshailo, N.E.; Sokolova, V.A.; Zaitsev, G.D.

    1985-01-01

    This paper describes two high-perveance electron guns with longitudinal compression: EP-5/3.5 (MKG) and EP-10/5 (MKG), which are intended to be placed outside the vacuum chamber and which are small in size and mass. The guns with vacuum-tight bodies have the same current, perveance, current transmission coefficient, and dependence of beam power on potential as did the initial forms of the same guns without vacuum-tight bodies. The maximum beam power and the maximum working pressure are reduced in the sealed-body guns.

  10. Airplane transport isolators may loose leak tightness after rapid cabin decompression.

    PubMed

    Albrecht, Roland; Kunz, Andres; Voelckel, Wolfgang G

    2015-01-01

    Air medical transport of patients suffering of highly infectious diseases is typically performed employing portable isolation chambers. Although the likelihood of decompression flight emergencies is low, sustainability of the devices used is crucial. When a standard isolation unit was subjected to an explosive cabin decompression of 493 hPa, simulating a 32808 ft flight level accident, leak tightness of the unit was lost due to rupture of the bag caused by over expansion. When the pressure chamber experiment was repeated with a modified unit, distension was minimized by an additional compensation air bag, thus ensuring leak tightness. PMID:25887737

  11. Tight Bra in a 34-Year-Old Woman: An Unusual Cause of Mondor's Disease.

    PubMed

    Vincenza Polito, Maria; De Cicco, Pierluigi; Apicella, Rosa

    2014-01-01

    Mondor's disease is characterized by thrombophlebitis of the superficial veins of the breast and the chest wall. The list of causes is long. Various types of clothing, mainly tight bras and girdles, have been postulated as causes. We report a case of a 34-year-old woman who referred typical symptoms and signs of Mondor's disease, without other possible risk factors, and showed the cutaneous findings of the tight bra. Therefore, after distinguishing benign causes of Mondor's disease from hidden malignant causes, the clinicians should consider this clinical entity. PMID:24995060

  12. Ultrasonic precision optical grinding technology

    NASA Astrophysics Data System (ADS)

    Cahill, Michael J.; Bechtold, Michael J.; Fess, Edward; Wolfs, Frank L.; Bechtold, Rob

    2015-10-01

    As optical geometries become more precise and complex and a wider range of materials are used, the processes used for manufacturing become more critical. As the preparatory stage for polishing, this is especially true for grinding. Slow processing speeds, accelerated tool wear, and poor surface quality are often detriments in manufacturing glass and hard ceramics. The quality of the ground surface greatly influences the polishing process and the resulting finished product. Through extensive research and development, OptiPro Systems has introduced an ultrasonic assisted grinding technology, OptiSonic, which has numerous advantages over traditional grinding processes. OptiSonic utilizes a custom tool holder designed to produce oscillations in line with the rotating spindle. A newly developed software package called IntelliSonic is integral to this platform. IntelliSonic automatically characterizes the tool and continuously optimizes the output frequency for optimal cutting while in contact with the part. This helps maintain a highly consistent process under changing load conditions for a more accurate surface. Utilizing a wide variety of instruments, test have proven to show a reduction in tool wear and increase in surface quality while allowing processing speeds to be increased. OptiSonic has proven to be an enabling technology to overcome the difficulties seen in grinding of glass and hard optical ceramics. OptiSonic has demonstrated numerous advantages over the standard CNC grinding process. Advantages are evident in reduced tool wear, better surface quality, and reduced cycle times due to increased feed rates. These benefits can be seen over numerous applications within the precision optics industry.

  13. SmallSat Precision Navigation with Low-Cost MEMS IMU Swarms

    NASA Technical Reports Server (NTRS)

    Christian, John; Bishop, Robert; Martinez, Andres; Petro, Andrew

    2015-01-01

    The continued advancement of small satellite-based science missions requires the solution to a number of important technical challenges. Of particular note is that small satellite missions are characterized by tight constraints on cost, mass, power, and volume that make them unable to fly the high-quality Inertial Measurement Units (IMUs) required for orbital missions demanding precise orientation and positioning. Instead, small satellite missions typically fly low-cost Micro-Electro-Mechanical System (MEMS) IMUs. Unfortunately, the performance characteristics of these MEMS IMUs make them ineffectual in many spaceflight applications when employed in a single IMU system configuration.

  14. Making Precise Antenna Reflectors For Millimeter Wavelengths

    NASA Technical Reports Server (NTRS)

    Sharp, G. Richard; Wanhainen, Joyce S.; Ketelsen, Dean A.

    1994-01-01

    In improved method of fabrication of precise, lightweight antenna reflectors for millimeter wavelengths, required precise contours of reflecting surfaces obtained by computer numberically controlled machining of surface layers bonded to lightweight, rigid structures. Achievable precision greater than that of older, more-expensive fabrication method involving multiple steps of low- and high-temperature molding, in which some accuracy lost at each step.

  15. Precision Farming and Conservation Advances Agricultural Sustainability

    Technology Transfer Automated Retrieval System (TEKTRAN)

    To many, Precision Farming, more formally termed Precision Agriculture, seems like an oxymoron. Yet site-specific management makes sense to an exponentially growing number of farmers. So where is Precision Farming headed? The short answer is that it is being extended from a focus on crop productio...

  16. Precision grinding process development for brittle materials

    SciTech Connect

    Blaedel, K L; Davis, P J; Piscotty, M A

    1999-04-01

    High performance, brittle materials are the materials of choice for many of today's engineering applications. This paper describes three separate precision grinding processes developed at Lawrence Liver-more National Laboratory to machine precision ceramic components. Included in the discussion of the precision processes is a variety of grinding wheel dressing, truing and profiling techniques.

  17. A new algorithm for tight integration of real-time GPS and strong-motion records, demonstrated on simulated, experimental, and real seismic data

    NASA Astrophysics Data System (ADS)

    Tu, Rui; Ge, Maorong; Wang, Rongjiang; Walter, Thomas R.

    2014-01-01

    The complementary advantages of GPS and seismic measurements are well recognized in seismotectonic monitoring studies. Therefore, integrated processing of the two data streams has been proposed recently in an attempt to obtain accurate and reliable information of surface displacements associated with earthquakes. A hitherto still critical issue in the integrated processing is real-time detection and precise estimation of the transient baseline error in the seismic records. Here, we report on a new approach by introducing the seismic acceleration corrected by baseline errors into the state equation system. The correction is performed and regularly updated in short epochs (with increments which may be as short as seconds), so that station position, velocity, and acceleration can be constrained very tightly and baseline error can be estimated as a random-walk process. With the adapted state equation system, our study highlights the use of a new approach developed for integrated processing of GPS and seismic data by means of sequential least-squares adjustment. The efficiency of our approach is demonstrated and validated using simulated, experimental, and real datasets. The latter were collected at collocated GPS and seismic stations around the 4 April 2010, E1 Mayor-Cucapah earthquake (Mw, 7.2). The results have shown that baseline errors of the strong-motion sensors are corrected precisely and high-precision seismic displacements are real-timely obtained by the new approach.

  18. Water tight.

    PubMed

    Postel, S

    1993-01-01

    Many cities worldwide have gone beyond the limits of their water supply. Growing urban populations increase their demand for water, thereby straining local water supplies and requiring engineers to seek our even more distant water sources. It is costly to build and maintain reservoirs, canals, pumping stations, pipes, sewers, and treatment plants. Water supply activities require much energy and chemicals, thereby contributing to environmental pollution. Many cities are beginning to manage the water supply rather than trying to keep up with demand. Pumping ground water for Mexico City's 18 million residents (500,000 people added/year) surpasses natural replenishment by 50% to 80%, resulting in falling water tables and compressed aquifers. Mexico City now ambitiously promotes replacement of conventional toilets with 1.6 gallon toilets (by late 1991, this had saved almost 7.4 billion gallons of water/year). Continued high rural-urban migration and high birth rates could negate any savings, however. Waterloo, Ontario, has also used conservation efforts to manage water demand. These efforts include retrofit kits to make plumbing fixtures more efficient, efficiency standards for plumbing fixtures, and reduction of water use outdoors. San Jose, California, has distributed water savings devices to about 220,000 households with a 90% cooperation rate. Boston, Massachusetts, not only promoted water saving devices but also repaired leaks and had an information campaign. Increasing water rates to actually reflect true costs also leads to water conservation, but not all cities in developing countries use water meters. All households in Edmonton, Alberta, are metered and its water use is 1/2 of that of Calgary, where only some households are metered. Tucson, Arizona, reduced per capita water use 16% by raising water rates and curbing water use on hot days. Bogor, Indonesia, reduced water use almost 30% by increasing water rates. In the US, more and more states are mandating use of water-efficient plumbing fixtures. Multilateral development agencies have identified some developing country cities as demonstrated sites for urban water conservation. PMID:12286138

  19. Leak testing of bubble-tight dampers using tracer gas techniques

    SciTech Connect

    Lagus, P.L.; DuBois, L.J.; Fleming, K.M.

    1995-02-01

    Recently tracer gas techniques have been applied to the problem of measuring the leakage across an installed bubble-tight damper. A significant advantage of using a tracer gas technique is that quantitative leakage data are obtained under actual operating differential pressure conditions. Another advantage is that leakage data can be obtained using relatively simple test setups that utilize inexpensive materials without the need to tear ducts apart, fabricate expensive blank-off plates, and install test connections. Also, a tracer gas technique can be used to provide an accurate field evaluation of the performance of installed bubble-tight dampers on a periodic basis. Actual leakage flowrates were obtained at Zion Generating Station on four installed bubble-tight dampers using a tracer gas technique. Measured leakage rates ranged from 0.01 CFM to 21 CFM. After adjustment and subsequent retesting, the 21 CFM damper leakage was reduced to a leakage of 3.8 CFM. In light of the current regulatory climate and the interest in Control Room Habitability issues, imprecise estimates of critical air boundary leakage rates--such as through bubble-tight dampers--are not acceptable. These imprecise estimates can skew radioactive dose assessments as well as chemical contaminant exposure calculations. Using a tracer gas technique, the actual leakage rate can be determined. This knowledge eliminates a significant source of uncertainty in both radioactive dose and/or chemical exposure assessments.

  20. Modulation of the chloroplast ATPase by tight ADP binding. Effect of uncouplers and ATP.

    PubMed

    Bar-Zvi, D; Shavit, N

    1982-12-01

    Inactivation of the membrane-bound ATPase by tight ADP binding was studied under nonenergized conditions. The energy state of the system was controlled either by omitting MgCl2, preventing ATP hydrolysis, or by addition of an uncoupler which dissipates the delta mu H+. In the absence of Mg2+, ATP prevents the inactivation of the enzyme by ADP, in a competitive manner. This effect of ATP resembles that of GDP with Mg2+ present. In the presence of nigericin, Mg2+, and ATP, inactivation occurs after a 10-15-sec interval, during which the enzyme is able to hydrolyze ATP at a relatively rapid rate. The degree of inactivation is proportional to the level of bound ADP detected. This behavior is different from that of the coupled ATPase (no uncoupler added), where inactivation is attained only upon exhaustion of the ATP by its hydrolysis, despite the finding that ADP binds tightly to the active ATPase at all stages of the reaction. Higher levels of tightly bound ADP were detected in the presence of an uncoupler. We suggest that the interval during which the enzyme becomes inactive is that required for the enzyme to generate and bind ADP, and to change from the active to the inactive conformation. These results support the mechanism suggested previously for the modulation of the ATPase by tight nucleotide binding. PMID:6219104

  1. The Passions of Learning in Tight Circumstances: Toward a Political Economy of the Mind

    ERIC Educational Resources Information Center

    McDermott, Ray

    2010-01-01

    Economies make their demands, and by necessity, people adjust, learn, and survive. People adjust to tight circumstances with passion and ingenuity. Necessity and its passions are the stuff of reality and generally more than schools or educational research can handle. Mainstream theories of learning have captured economic constraints only…

  2. Results from tight and loose coupled multiphysics in nuclear fuels performance simulations using BISON

    SciTech Connect

    Novascone, S. R.; Spencer, B. W.; Andrs, D.; Williamson, R. L.; Hales, J. D.; Perez, D. M.

    2013-07-01

    The behavior of nuclear fuel in the reactor environment is affected by multiple physics, most notably heat conduction and solid mechanics, which can have a strong influence on each other. To provide credible solutions, a fuel performance simulation code must have the ability to obtain solutions for each of the physics, including coupling between them. Solution strategies for solving systems of coupled equations can be categorized as loosely-coupled, where the individual physics are solved separately, keeping the solutions for the other physics fixed at each iteration, or tightly coupled, where the nonlinear solver simultaneously drives down the residual for each physics, taking into account the coupling between the physics in each nonlinear iteration. In this paper, we compare the performance of loosely and tightly coupled solution algorithms for thermomechanical problems involving coupled thermal and mechanical contact, which is a primary source of interdependence between thermal and mechanical solutions in fuel performance models. The results indicate that loosely-coupled simulations require significantly more nonlinear iterations, and may lead to convergence trouble when the thermal conductivity of the gap is too small. We also apply the tightly coupled solution strategy to a nuclear fuel simulation of an experiment in a test reactor. Studying the results from these simulations indicates that perhaps convergence for either approach may be problem dependent, i.e., there may be problems for which a loose coupled approach converges, where tightly coupled won't converge and vice versa. (authors)

  3. AUV Positioning Method Based on Tightly Coupled SINS/LBL for Underwater Acoustic Multipath Propagation

    PubMed Central

    Zhang, Tao; Shi, Hongfei; Chen, Liping; Li, Yao; Tong, Jinwu

    2016-01-01

    This paper researches an AUV (Autonomous Underwater Vehicle) positioning method based on SINS (Strapdown Inertial Navigation System)/LBL (Long Base Line) tightly coupled algorithm. This algorithm mainly includes SINS-assisted searching method of optimum slant-range of underwater acoustic propagation multipath, SINS/LBL tightly coupled model and multi-sensor information fusion algorithm. Fuzzy correlation peak problem of underwater LBL acoustic propagation multipath could be solved based on SINS positional information, thus improving LBL positional accuracy. Moreover, introduction of SINS-centered LBL locating information could compensate accumulative AUV position error effectively and regularly. Compared to loosely coupled algorithm, this tightly coupled algorithm can still provide accurate location information when there are fewer than four available hydrophones (or within the signal receiving range). Therefore, effective positional calibration area of tightly coupled system based on LBL array is wider and has higher reliability and fault tolerance than loosely coupled. It is more applicable to AUV positioning based on SINS/LBL. PMID:26978361

  4. Rock matrix and fracture analysis of flow in western tight gas sands: Annual report, Phase 3

    SciTech Connect

    Dandge, V.; Graham, M.; Gonzales, B.; Coker, D.

    1987-12-01

    Tight gas sands are a vast future source of natural gas. These sands are characterized as having very low porosity and permeability. The main resource development problem is efficiently extracting the gas from the reservoir. Future production depends on a combination of gas price and technological advances. Gas production can be enhanced by fracturing. Studies have shown that many aspects of fracture design and gas production are influenced by properties of the rock matrix. Computer models for stimulation procedures require accurate knowledge of flow properties of both the rock matrix and the fractured regions. In the proposed work, these properties will be measured along with advanced core analysis procedure aimed at understanding the relationship between pore structure and properties. The objective of this project is to develop reliable core analysis techniques for measuring the petrophysical properties of tight gas sands. Recent research has indicated that the flow conditions in the reservoir can be greatly enhanced by the presence of natural fractures, which serve as a transport path for gas from the less permeable matrix. The study is mainly concerned with the dependence of flow in tight gas matrix and healed tectonic fractures on water saturation and confining pressure. This dependency is to be related to the detailed pore structure of tight sands as typified by cores recovered in the Multi-Well experiment. 22 refs., 34 figs., 9 tabs.

  5. 42 CFR 84.1142 - Isoamyl acetate tightness test; respirators designed for respiratory protection against dusts...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Isoamyl acetate tightness test; respirators designed for respiratory protection against dusts, fumes, and mists having an air contamination level less... dusts, fumes, and mists having an air contamination level less than 0.05 milligram per cubic meter,...

  6. 42 CFR 84.1142 - Isoamyl acetate tightness test; respirators designed for respiratory protection against dusts...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Isoamyl acetate tightness test; respirators designed for respiratory protection against dusts, fumes, and mists having an air contamination level less... dusts, fumes, and mists having an air contamination level less than 0.05 milligram per cubic meter,...

  7. Naturally fractured tight gas reservoir detection optimization. Quarterly technical progress report, April 1995--June 1995

    SciTech Connect

    1995-08-01

    Research continued on methods to detect naturally fractured tight gas reservoirs. This report contains a seismic survey map, and reports on efforts towards a source test to select the source parameters for a 37 square mile compressional wave 3-D seismic survey. Considerations of the source tests are discussed.

  8. Tight binding study of transition ions in silicon and E.P.R. spectra

    NASA Astrophysics Data System (ADS)

    Pecheur, P.; Toussaint, G.

    1983-02-01

    A tight binding scheme is used to study the electronic structure of transition ions in silicon. Self consistency and spin polarization are introduced in a simple way. Results are obtained for interstitial and substitutional Cr, Mn and Fe impurities. They are compared to E.P.R. experiments and cluster Xα results.

  9. Sonic and electrical properties of partially saturated tight-gas sands. Final report

    SciTech Connect

    Nur, A.

    1983-03-01

    This study was aimed at relating the seismic and the electrical properties of tight-gas rocks to their pore-space geometry, permeability, and level of water saturation. Here we report results of a laboratory experimental study of wave propagation in Cotton Valley and Spirit River Sandstones as a function of partial water saturation (SW) and wave frequency. We find that wave velocities and the velocity ratio are sensitive to the presence of gas. Furthermore, wave attenuation is sensitive to the amount of gas in the pore space. Ultrasonic measurements in tight-gas sands tend to yield higher velocity values, due to the inability of the pore fluid pressure to homogenize during the passage of waves. Laboratory measurements were made also of the complex electrical response of selected tight rocks, and compared with normal permeability Berea Sandstone. The results show that the dielectric property of tight-gas sands is very sensitive to partial water saturation, and may give not only insight into the nature of the pore space, but also provide a practical measure of S/sub w/ in situ. 35 figures, 2 tables.

  10. Production of Natural Gas and Fluid Flow in Tight Sand Reservoirs

    SciTech Connect

    Maria Cecilia Bravo; Mariano Gurfinkel

    2005-06-30

    This document reports progress of this research effort in identifying possible relationships and defining dependencies between macroscopic reservoir parameters strongly affected by microscopic flow dynamics and production well performance in tight gas sand reservoirs. Based on a critical review of the available literature, a better understanding of the main weaknesses of the current state of the art of modeling and simulation for tight sand reservoirs has been reached. Progress has been made in the development and implementation of a simple reservoir simulator that is still able to overcome some of the deficiencies detected. The simulator will be used to quantify the impact of microscopic phenomena in the macroscopic behavior of tight sand gas reservoirs. Phenomena such as, Knudsen diffusion, electro-kinetic effects, ordinary diffusion mechanisms and water vaporization are being considered as part of this study. To date, the adequate modeling of gas slippage in porous media has been determined to be of great relevance in order to explain unexpected fluid flow behavior in tight sand reservoirs.

  11. Results from Tight and Loose Coupled Multiphysics in Nuclear Fuels Performance Simulations using BISON

    SciTech Connect

    S. R. Novascone; B. W. Spencer; D. Andrs; R. L. Williamson; J. D. Hales; D. M. Perez

    2013-05-01

    The behavior of nuclear fuel in the reactor environment is affected by multiple physics, most notably heat conduction and solid mechanics, which can have a strong influence on each other. To provide credible solutions, a fuel performance simulation code must have the ability to obtain solutions for each of the physics, including coupling between them. Solution strategies for solving systems of coupled equations can be categorized as loosely-coupled, where the individual physics are solved separately, keeping the solutions for the other physics fixed at each iteration, or tightly coupled, where the nonlinear solver simultaneously drives down the residual for each physics, taking into account the coupling between the physics in each nonlinear iteration. In this paper, we compare the performance of loosely and tightly coupled solution algorithms for thermomechanical problems involving coupled thermal and mechanical contact, which is a primary source of interdependence between thermal and mechanical solutions in fuel performance models. The results indicate that loosely-coupled simulations require significantly more nonlinear iterations, and may lead to convergence trouble when the thermal conductivity of the gap is too small. We also apply the tightly coupled solution strategy to a nuclear fuel simulation of an experiment in a test reactor. Studying the results from these simulations indicates that perhaps convergence for either approach may be problem dependent, i.e., there may be problems for which a loose coupled approach converges, where tightly coupled won’t converge and vice versa.

  12. Assessment of tight-gas resources in Canyon sandstones of the Val Verde Basin, Texas, 2016

    USGS Publications Warehouse

    Schenk, Christopher J.; Tennyson, Marilyn E.; Klett, Timothy R.; Mercier, Tracey J.; Brownfield, Michael E.; Gaswirth, Stephanie B.; Hawkins, Sarah J.; Leathers-Miller, Heidi M.; Marra, Kristen R.; Finn, Thomas M.; Pitman, Janet K.

    2016-01-01

    Using a geology-based assessment methodology, the U.S. Geological Survey assessed mean resources of 5 trillion cubic feet of gas and 187 million barrels of natural gas liquids in tight-gas assessment units in the Canyon sandstones of the Val Verde Basin, Texas.

  13. Implications of Increasing Light Tight Oil Production for U.S. Refining

    EIA Publications

    2015-01-01

    EIA retained Turner, Mason & Company to provide analysis of the implications of increasing domestic light tight oil production for U.S. refining, focusing on regional crude supply/demand balances, refinery crude slates, operations, capital investment, product yields, crude oil exports/imports, petroleum product exports, infrastructure constraints and expansions, and crude oil price relationships.

  14. Patient Positioning and Skin Sequelae: Ischemic Epidermal Necrosis from Tight Padding During Cardiac Surgery.

    PubMed

    Sadeghpour, Mona; Au, Jeremiah; Ho, Jonhan; Hyman, Jaime; Patton, Timothy

    2016-05-15

    Careful positioning and padding of pressure points during surgery are recommended to prevent pressure ulcers, vascular injury, and nerve damage in an immobilized patient. However, overpadding may have unintended consequences. We report a case of ischemia-induced full-thickness epidermal necrosis secondary to tight foam padding during a cardiac surgery. PMID:26934606

  15. Hyperinflation Approach to a Tight-Binding Model in Quasiperiodic Chains

    NASA Astrophysics Data System (ADS)

    Odagaki, Takashi

    1992-10-01

    The hyperinflation technique is shown to be an efficient way to obtain the energy bands, the density and integrated density of states for a tight-binding electron in one-dimensional quasicrystals and their approximants. Within the semiclassical treatment of a carrier dynamics, the approximant crystals are shown to exhibit negative differential conductivity for sufficiently strong fields.

  16. Electron-hole correlations in semiconductor quantum dots with tight-binding wave fuctions

    NASA Technical Reports Server (NTRS)

    Seungwon, L.; Jonsson, L.; Wilkins, J.; Bryant, G.; Klimeck, G.

    2001-01-01

    The electron-hole states of semiconductor quantum dots are investigated within the framework of empirical tight-binding descriptions for Si, as an example of an indirect-gap material, and InAs and CdSe as examples of typical III-V and II-VI direct-gap materials.

  17. a Mixed-Fractal Flow Model for Stimulated Fractured Vertical Wells in Tight Oil Reservoirs

    NASA Astrophysics Data System (ADS)

    Su, Yuliang; Sheng, Guanglong; Wang, Wendong; Zhang, Qi; Lu, Mingjing; Ren, Long

    2016-02-01

    Stimulated reservoir volume (SRV) with large fracture networks can be generated near hydraulic fractured vertical wells (HFVWs) in tight oil reservoirs. Statistics show that natural microfractures and fracture networks stimulated by SRV were self-similar in statistical sense. Currently, various analytical models have been presented to study pressure behaviors of HFVWs in tight oil reservoirs. However, most of the existing models did not take the distribution and self-similarity of fractures into consideration. To account for stimulated characteristic and self-similarity of fractures in tight oil reservoirs, a mixed-fractal flow model was presented. In this model, there are two distinct regions, stimulated region and unstimulated region. Dual-porosity model and single porosity model were used to model stimulated and unstimulated regions, respectively. Fractal geometry is employed to describe fractal permeability and porosity relationship (FPPR) in tight oil reservoirs. Solutions for the mixed-fractal flow model were derived in the Laplace domain and were validated among range of the reservoir parameters. The pressure transient behavior and production rate derivative were used to analyze flow regimes. The type curves show that the fluid flow in HFVWs can be divided into six main flow periods. Finally, effect of fractal parameters and SRV size on flow periods were also discussed. The results show that the SRV size and fractal parameters of fracture network have great effect on the former periods and fractal parameters of matrix mainly influence the later flow periods.

  18. Simple analytical derivation of the fields of an ultrashort tightly focused linearly polarized laser pulse

    NASA Astrophysics Data System (ADS)

    Salamin, Yousef I.

    2015-12-01

    Analytic expressions for the electric and magnetic fields of an ultrashort, tightly focused, linearly polarized laser pulse are derived, to lowest order of a truncated power-series expansion, from vector and scalar potentials. Clear steps are described for the analytic and numerical evaluation of higher-order terms in the series, to any desired accuracy.

  19. AUV Positioning Method Based on Tightly Coupled SINS/LBL for Underwater Acoustic Multipath Propagation.

    PubMed

    Zhang, Tao; Shi, Hongfei; Chen, Liping; Li, Yao; Tong, Jinwu

    2016-01-01

    This paper researches an AUV (Autonomous Underwater Vehicle) positioning method based on SINS (Strapdown Inertial Navigation System)/LBL (Long Base Line) tightly coupled algorithm. This algorithm mainly includes SINS-assisted searching method of optimum slant-range of underwater acoustic propagation multipath, SINS/LBL tightly coupled model and multi-sensor information fusion algorithm. Fuzzy correlation peak problem of underwater LBL acoustic propagation multipath could be solved based on SINS positional information, thus improving LBL positional accuracy. Moreover, introduction of SINS-centered LBL locating information could compensate accumulative AUV position error effectively and regularly. Compared to loosely coupled algorithm, this tightly coupled algorithm can still provide accurate location information when there are fewer than four available hydrophones (or within the signal receiving range). Therefore, effective positional calibration area of tightly coupled system based on LBL array is wider and has higher reliability and fault tolerance than loosely coupled. It is more applicable to AUV positioning based on SINS/LBL. PMID:26978361

  20. Tightly wrapped semiconductor-axon microtubes for probing hybrid networks: Modeling the capacitive coupling strength

    NASA Astrophysics Data System (ADS)

    Diedrich, Daniel; Blick, Robert H.

    2015-02-01

    We present finite-element simulations modeling the electromagnetic interaction between axons and semiconductor microtubes. These tubes are tightly wrapped around the axons, enabling highly efficient capacitive coupling. The calculations reveal that the capacitive coupling strength is in the pA regime.

  1. 42 CFR 84.1142 - Isoamyl acetate tightness test; respirators designed for respiratory protection against dusts...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Isoamyl acetate tightness test; respirators designed for respiratory protection against dusts, fumes, and mists having an air contamination level less... dusts, fumes, and mists having an air contamination level less than 0.05 milligram per cubic meter,...

  2. 42 CFR 84.1142 - Isoamyl acetate tightness test; respirators designed for respiratory protection against dusts...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Isoamyl acetate tightness test; respirators designed for respiratory protection against dusts, fumes, and mists having an air contamination level less... dusts, fumes, and mists having an air contamination level less than 0.05 milligram per cubic meter,...

  3. 42 CFR 84.1142 - Isoamyl acetate tightness test; respirators designed for respiratory protection against dusts...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Isoamyl acetate tightness test; respirators designed for respiratory protection against dusts, fumes, and mists having an air contamination level less... dusts, fumes, and mists having an air contamination level less than 0.05 milligram per cubic meter,...

  4. ENVIRONMENTAL TECHNOLOGY VERIFICATION REPORT THE PROTECTOSEAL COMPANY PIN-TECH BUBBLE TIGHT < 500 PPM RELIEF VENT

    EPA Science Inventory

    The Environmental Technology Verification report discusses the technology and performance of a pressure relief valve for protection of storage tanks that operate at pressures of 15 psig or less. Four Pin-Tech Bubble Tight <500 ppm Relief Vent valves manufactured by the Protectose...

  5. Relationship between Lower Extremity Tightness and Star Excursion Balance Test Performance in Junior High School Baseball Players.

    PubMed

    Endo, Yasuhiro; Sakamoto, Masaaki

    2014-05-01

    [Purpose] The purpose of this study was to examine the relationship between lower extremity tightness and lower extremity balance, measured by the Star Excursion Balance Test (SEBT), in junior high school baseball players. [Subjects] Thirty-three male students belonging to baseball clubs in 2 junior high schools participated in this study. [Methods] For the SEBT, we chose to examine the anterior (ANT), posterior (POS), lateral (LAT), and medial (MED) directions. Regarding muscle tightness measurement, the angle of each joint of the bilateral iliopsoas, quadriceps, hamstring, gastrocnemius, hip internal rotator, and hip external rotator was measured. [Results] The ANT direction of the SEBT was significantly negatively correlated with gastrocnemius tightness. The MED direction of the SEBT was significantly positively correlated with hip internal rotator tightness and hamstrings tightness and significantly negatively correlated with gastrocnemius tightness. The LAT direction of the SEBT was significantly negatively correlated with iliopsoas tightness and gastrocnemius tightness. [Conclusion] Since the rate of upper extremity injury is high in these subjects and this could be due to tightness and instability of the lower extremity from a kinetic viewpoint, the SEBT could be used as a standard evaluation test when examining upper extremity injuries in young baseball players. PMID:24926127

  6. Novel gas-tight multi-sampler for discrete deep-sea water

    NASA Astrophysics Data System (ADS)

    Huang, Haocai; Yang, Canjun; Chen, Shicheng; Chen, Daohua; Sun, Chunyan; Niu, Wenda; Li, Fengbo; Liu, Guanghu; Chen, Ying

    2012-07-01

    The issues of how to quickly collect seawater samples and of how to make sure that those samples truly reflect the in-situ information on gas composition and concentration have therefore become a hot but difficult topic in the field of ocean technology. Most conventional seawater samplers only focus on collecting seawater itself, but take little consideration on gas preservation. A set of new oceanographic tools are presented for ocean resource exploration such as hydrothermal sulfide and gas hydrate, and for investigations on the processes and mechanisms of marine physical, chemical and biological evolutions. A gas-tight deep-sea water sampling system (GTWSS) is designed for the collection of deep-sea geochemical samples. This set of tools mainly consists of a conductivity temperature depth profiler (CTD), release devices and gas-tight deep-sea water samplers (GTWS). The GTWS is able to hold the gases in deep-sea water samples tightly, providing in-situ information on gas contents in the seawater samples and can be deployed on a routine wire-deployed CTD sampler for multi-layer discrete sampling of gas-tight seawater. Sea trials are performed successfully in 2008 and 2009, on a research vessel named HaiYang Si Hao in South China Sea, with the deepest trial depth 3 930 m. GTWSS is capable of quickly sampling 12 discrete gas-tight seawater samples (8.3 L per sample) during its single deployment. The head space method is employed to separate the gases from the seawater samples immediately after recovery of the seawater samples on the vessel. Field geochemical analysis is carried out by gaseous hydrocarbon sensors and an infrared gas analyzer. Results show that the concentrations of CH4 and CO2 in the seawater sampled by GTWSS are higher than those sampled by general non-gas-tight water samplers, thus confirming the gas tightness of GTWSS. Seawater samples can be collected quickly by using GTWSS, and GTWSS can keep the samples' integrity quite well.

  7. The Age of Precision Cosmology

    NASA Technical Reports Server (NTRS)

    Chuss, David T.

    2012-01-01

    In the past two decades, our understanding of the evolution and fate of the universe has increased dramatically. This "Age of Precision Cosmology" has been ushered in by measurements that have both elucidated the details of the Big Bang cosmology and set the direction for future lines of inquiry. Our universe appears to consist of 5% baryonic matter; 23% of the universe's energy content is dark matter which is responsible for the observed structure in the universe; and 72% of the energy density is so-called "dark energy" that is currently accelerating the expansion of the universe. In addition, our universe has been measured to be geometrically flat to 1 %. These observations and related details of the Big Bang paradigm have hinted that the universe underwent an epoch of accelerated expansion known as Uinflation" early in its history. In this talk, I will review the highlights of modern cosmology, focusing on the contributions made by measurements of the cosmic microwave background, the faint afterglow of the Big Bang. I will also describe new instruments designed to measure the polarization of the cosmic microwave background in order to search for evidence of cosmic inflation.

  8. PRECISION TIME-DELAY GENERATOR

    DOEpatents

    Carr, B.J.; Peckham, V.D.

    1959-06-16

    A precision time-delay generator circuit with low jitter is described. The first thyratron has a series resonant circuit and a diode which is connected to the second thyratron. The first thyratron is triggered at the begin-ning of a time delay and a capacitor is discharged through the first thyratron and the diode, thereby, triggering the second thyratron. (T.R.H.) l6l9O The instrument described can measure pressures between sea level and 300,000 ft. The pressure- sensing transducer of the instrument is a small cylindrical tube with a thin foil of titanium-tritium fastened around the inside of the tube. Output is a digital signal which can be used for storage or telemetering more conveniently than an analog signal. (W.D.M.) l6l9l An experimental study was made on rolling contacts in the temperature range of 550 to 1000 deg F. Variables such as material composition, hardness, and operating conditions were investigated in a rolling test stand. Ball bearing tests were run to determine the effect of design parameters, bearing materials, lubricants, and operating conditions. (auth)

  9. Precision conformal optics technology program

    NASA Astrophysics Data System (ADS)

    Trotta, Patrick A.

    2001-09-01

    Conformal optics are defined as optics that deviate from conventional form to best satisfy the contour and shape needs of system platforms. Precision Conformal Optics Technology (PCOT), a comprehensive 48 month program funded by the Defense Advanced Research Program Agency (DARPA) and the U. S. Army Missile Research, Development, and Engineering Center (MRDEC), assessed the potential benefits achieved by use of conformal optics on a variety of U.S. weapon systems. Also addressed were all barriers impeding conformal optics use. The PCOT program was executed by a consortium of organizations ranging from major U.S. defense prime contractors, to small businesses, and academia. The diversity of organizations encouraged synergy across a broad array of skills and perspectives. Smooth team interaction was made possible by the 845 contractual structure of the program. Benefits identified by the PCOT consortium included major reductions in aerodynamic drag (by as much as 50%), reduced time-to-targets (by as much as 60%), and reduced weapon signatures. Impediments addressed included inadequacies in optical design tools, optical manufacturing methods and equipment, optical testing, and system integration. The PCOT program was successfully completed with a demonstration of a highly contoured missile dome, which reduced overall missile drag by 25%, and led to a predicted twofold increase in missile range.

  10. Precision Photometric Redshifts Of Clusters

    NASA Astrophysics Data System (ADS)

    Holden, L.; Annis, J.

    2006-06-01

    Clusters of galaxies provide a means to achieve more precise photometric redshifts than achievable using individual galaxies simply because of the numbers of galaxies available in clusters. Here we examine the expectation that one can achieve root-N improvement using the N galaxies in a cluster. We extracted from a maxBCG SDSS cluster catalog 28,000 clusters and used SDSS DR4 spectra to find spectroscopic redshifts for the cluster. We examined both using the brightest cluster galaxy redshift as the proxy for the cluster and using the mean of a collection of galaxies within a given angular diameter and redshift (about the cluster photo-z) range. We find that the BCG provides a better estimate of the cluster redshift, to be understood in the context of a handful of spectra in the neighborhood of the cluster. We find that the cluster photo-z has an approximate root-N scaling behavior with the normalization for maxBCG techniques being 0.07. We predict what ``afterburner photo-z'' techniques, which use individual galaxy photo-z's good to 0.03-0.05, can achieve for cluster catalogs and for cluster cosmology.

  11. Developments in precision asphere manufacturing

    NASA Astrophysics Data System (ADS)

    Tierson, Jay; Fess, Ed; Matthews, Greg

    2015-10-01

    The increased use of aspheres in today's optical systems has led to specialized manufacturing equipment and processes that are needed to meet component specifications. Due to their sub-aperture nature, each stage of these processes can leave behind a signature that could adversely affect the asphere's overall performance. Utilizing a variety of grinding and polishing techniques can help minimize residual artifacts that are left in an asphere. OptiPro has performed extensive process development work to understand how to grind and polish aspheres at production speeds with minimized process signatures. For example, the amount of stock removed from a substrate using a sub aperture polishing process can increase the amount of mid-spacial frequencies that can be detected. Through precise grind control, sub aperture, and mid-aperture polishing process research, OptiPro developed a detailed knowledge of asphere process control. One of the outcomes of this work has led OptiPro to develop an asphere polishing head for their 160A polishing platform which allows more process flexibility and control.

  12. Ultra-precision positioning assembly

    DOEpatents

    Montesanti, Richard C.; Locke, Stanley F.; Thompson, Samuel L.

    2002-01-01

    An apparatus and method is disclosed for ultra-precision positioning. A slide base provides a foundational support. A slide plate moves with respect to the slide base along a first geometric axis. Either a ball-screw or a piezoelectric actuator working separate or in conjunction displaces the slide plate with respect to the slide base along the first geometric axis. A linking device directs a primary force vector into a center-line of the ball-screw. The linking device consists of a first link which directs a first portion of the primary force vector to an apex point, located along the center-line of the ball-screw, and a second link for directing a second portion of the primary force vector to the apex point. A set of rails, oriented substantially parallel to the center-line of the ball-screw, direct movement of the slide plate with respect to the slide base along the first geometric axis and are positioned such that the apex point falls within a geometric plane formed by the rails. The slide base, the slide plate, the ball-screw, and the linking device together form a slide assembly. Multiple slide assemblies can be distributed about a platform. In such a configuration, the platform may be raised and lowered, or tipped and tilted by jointly or independently displacing the slide plates.

  13. High precision redundant robotic manipulator

    DOEpatents

    Young, K.K.D.

    1998-09-22

    A high precision redundant robotic manipulator for overcoming contents imposed by obstacles or imposed by a highly congested work space is disclosed. One embodiment of the manipulator has four degrees of freedom and another embodiment has seven degrees of freedom. Each of the embodiments utilize a first selective compliant assembly robot arm (SCARA) configuration to provide high stiffness in the vertical plane, a second SCARA configuration to provide high stiffness in the horizontal plane. The seven degree of freedom embodiment also utilizes kinematic redundancy to provide the capability of avoiding obstacles that lie between the base of the manipulator and the end effector or link of the manipulator. These additional three degrees of freedom are added at the wrist link of the manipulator to provide pitch, yaw and roll. The seven degrees of freedom embodiment uses one revolute point per degree of freedom. For each of the revolute joints, a harmonic gear coupled to an electric motor is introduced, and together with properly designed based servo controllers provide an end point repeatability of less than 10 microns. 3 figs.

  14. High precision redundant robotic manipulator

    DOEpatents

    Young, Kar-Keung David

    1998-01-01

    A high precision redundant robotic manipulator for overcoming contents imposed by obstacles or imposed by a highly congested work space. One embodiment of the manipulator has four degrees of freedom and another embodiment has seven degreed of freedom. Each of the embodiments utilize a first selective compliant assembly robot arm (SCARA) configuration to provide high stiffness in the vertical plane, a second SCARA configuration to provide high stiffness in the horizontal plane. The seven degree of freedom embodiment also utilizes kinematic redundancy to provide the capability of avoiding obstacles that lie between the base of the manipulator and the end effector or link of the manipulator. These additional three degrees of freedom are added at the wrist link of the manipulator to provide pitch, yaw and roll. The seven degrees of freedom embodiment uses one revolute point per degree of freedom. For each of the revolute joints, a harmonic gear coupled to an electric motor is introduced, and together with properly designed based servo controllers provide an end point repeatability of less than 10 microns.

  15. Quantitative analysis of tightness of nuchal cord and its relationship with fetal intrauterine distress.

    PubMed

    Zhao, Fangui; Geng, Qiuying; Kong, Fanbin; Ning, Yan

    2015-01-01

    The perinatal outcomes of pregnancies with nuchal cord (NC) are uncertain and reports disagree about the incidence of cesarean section due to NC. Variable tightness of the NC may be a contributor to this controversy. The study was to examine whether the tightness of NC affect fetal intrauterine distress by determining valuable ultrasonic indicators. Total 149 singleton pregnancies between 36 and 41 weeks without pregnancy complications were recruited. The pregnant women, whose fetuses have NC, formed the study group and the others made up the control group. The ratio of peak systolic velocity and end diastolic velocity (S/D), pulsatility index (PI) of fetal umbilical artery (UA), middle cerebral artery (MCA) and renal artery (RA) were examed by ultrasound. We found that mean levels of S/D and PI of RA and the incidence of fetal distress and intervention rate during delivery were higher in the study group than those in control group (p<0.05). In contrast, the levels of RI of RA and flow spectrum parameters of UA and MCA showed no difference between the two groups (p>0.05). In addition, as compared with the control group, the mean levels of S/D and PI of RA, S/D of UA were higher in the tight subgroup (p<0.05). The S/D of UA and S/D, PI of RA were increased with D and A1/A, but there were no significant correlations between D or A1/A and fetal distress in study group. In summary, NC affects the level of flow spectrum parameters of RA and UA, especially in tight NC cases, which increases the rate of fetal intrauterine distress. A1/A% and D are valuable ultrasonographic indicator to describe the tightness of NC and predict the fetal hemodynamics, but they could not predict the fetal distress in our study. PMID:26770341

  16. Quantitative analysis of tightness of nuchal cord and its relationship with fetal intrauterine distress

    PubMed Central

    Zhao, Fangui; Geng, Qiuying; Kong, Fanbin; Ning, Yan

    2015-01-01

    The perinatal outcomes of pregnancies with nuchal cord (NC) are uncertain and reports disagree about the incidence of cesarean section due to NC. Variable tightness of the NC may be a contributor to this controversy. The study was to examine whether the tightness of NC affect fetal intrauterine distress by determining valuable ultrasonic indicators. Total 149 singleton pregnancies between 36 and 41 weeks without pregnancy complications were recruited. The pregnant women, whose fetuses have NC, formed the study group and the others made up the control group. The ratio of peak systolic velocity and end diastolic velocity (S/D), pulsatility index (PI) of fetal umbilical artery (UA), middle cerebral artery (MCA) and renal artery (RA) were examed by ultrasound. We found that mean levels of S/D and PI of RA and the incidence of fetal distress and intervention rate during delivery were higher in the study group than those in control group (p<0.05). In contrast, the levels of RI of RA and flow spectrum parameters of UA and MCA showed no difference between the two groups (p>0.05). In addition, as compared with the control group, the mean levels of S/D and PI of RA, S/D of UA were higher in the tight subgroup (p<0.05). The S/D of UA and S/D, PI of RA were increased with D and A1/A, but there were no significant correlations between D or A1/A and fetal distress in study group. In summary, NC affects the level of flow spectrum parameters of RA and UA, especially in tight NC cases, which increases the rate of fetal intrauterine distress. A1/A% and D are valuable ultrasonographic indicator to describe the tightness of NC and predict the fetal hemodynamics, but they could not predict the fetal distress in our study. PMID:26770341

  17. Potential restrictions for CO2 sequestration sites due to shale and tight gas production.

    PubMed

    Elliot, T R; Celia, M A

    2012-04-01

    Carbon capture and geological sequestration is the only available technology that both allows continued use of fossil fuels in the power sector and reduces significantly the associated CO(2) emissions. Geological sequestration requires a deep permeable geological formation into which captured CO(2)can be injected, and an overlying impermeable formation, called a caprock, that keeps the buoyant CO(2) within the injection formation. Shale formations typically have very low permeability and are considered to be good caprock formations. Production of natural gas from shale and other tight formations involves fracturing the shale with the explicit objective to greatly increase the permeability of the shale. As such, shale gas production is in direct conflict with the use of shale formations as a caprock barrier to CO(2) migration. We have examined the locations in the United States where deep saline aquifers, suitable for CO(2) sequestration, exist, as well as the locations of gas production from shale and other tight formations. While estimated sequestration capacity for CO(2) sequestration in deep saline aquifers is large, up to 80% of that capacity has areal overlap with potential shale-gas production regions and, therefore, could be adversely affected by shale and tight gas production. Analysis of stationary sources of CO(2) shows a similar effect: about two-thirds of the total emissions from these sources are located within 20 miles of a deep saline aquifer, but shale and tight gas production could affect up to 85% of these sources. These analyses indicate that colocation of deep saline aquifers with shale and tight gas production could significantly affect the sequestration capacity for CCS operations. This suggests that a more comprehensive management strategy for subsurface resource utilization should be developed. PMID:22352312

  18. Transient pressure behavior for a horizontal well with multiple finite-conductivity fractures in tight reservoirs

    NASA Astrophysics Data System (ADS)

    Guo, Jingjing; Wang, Haitao; Zhang, Liehui

    2015-08-01

    Horizontal drilling and multi-stage hydraulic fracturing have been common and efficient practices in exploitation of tight reservoirs. Establishing corresponding mathematical models and analyzing transient pressure behaviors of this type of well-reservoir configuration can provide a better understanding of fluid flow patterns in formation as well as estimations of important parameters. Most current models proposed for fractured horizontal wells in tight reservoirs do not incorporate either reservoir permeability loss during the production, which is believed to be non-ignorable or finite conductivity of hydraulic fractures. A coupling model for a multi-fractured horizontal well (MFHW) in tight reservoirs is presented in this article, in which finite conductivity of hydraulic fractures and stress-dependant reservoir permeability are taken into account simultaneously. A semi-analytical solution is obtained in the Laplace domain by using source function theory, Laplace transformation, perturbation technique, discretization of fractures, and superposition principle. Analysis of transient pressure responses indicates that several characteristic flow periods of fractured horizontal wells in tight reservoirs can be identified, including linear flow in fracture, bi-linear flow, linear flow in reservoir, pseudo-radial flow around fractures, and pseudo-radial flow around the horizontal wellbore and fractures. Parametric analysis shows that fracture conductivity, fracture spacing, fracture length, permeability modulus, and skin effect can significantly influence the transient pressure responses of fractured horizontal wells in tight reservoirs. The model presented in this article can be applied to obtain important parameters pertinent to reservoir or fractures by type curve matching, and it can also provide useful information for optimizing fracture parameters. Finally, the model presented in this article can also be easily extended to dual-porosity cases.

  19. A polyphenylene dendrimer drug transporter with precisely positioned amphiphilic surface patches.

    PubMed

    Stangenberg, René; Wu, Yuzhou; Hedrich, Jana; Kurzbach, Dennis; Wehner, Daniel; Weidinger, Gilbert; Kuan, Seah Ling; Jansen, Malin Insa; Jelezko, Fedor; Luhmann, Heiko J; Hinderberger, Dariush; Weil, Tanja; Müllen, Klaus

    2015-02-18

    The design and synthesis of a polyphenylene dendrimer (PPD 3) with discrete binding sites for lipophilic guest molecules and characteristic surface patterns is presented. Its semi-rigidity in combination with a precise positioning of hydrophilic and hydrophobic groups at the periphery yields a refined architecture with lipophilic binding pockets that accommodate defined numbers of biologically relevant guest molecules such as fatty acids or the drug doxorubicin. The size, architecture, and surface textures allow to even penetrate brain endothelial cells that are a major component of the extremely tight blood-brain barrier. In addition, low to no toxicity is observed in in vivo studies using zebrafish embryos. The unique PPD scaffold allows the precise placement of functional groups in a given environment and offers a universal platform for designing drug transporters that closely mimic many features of proteins. PMID:25182694

  20. Precision laser automatic tracking system.

    PubMed

    Lucy, R F; Peters, C J; McGann, E J; Lang, K T

    1966-04-01

    A precision laser tracker has been constructed and tested that is capable of tracking a low-acceleration target to an accuracy of about 25 microrad root mean square. In tracking high-acceleration targets, the error is directly proportional to the angular acceleration. For an angular acceleration of 0.6 rad/sec(2), the measured tracking error was about 0.1 mrad. The basic components in this tracker, similar in configuration to a heliostat, are a laser and an image dissector, which are mounted on a stationary frame, and a servocontrolled tracking mirror. The daytime sensitivity of this system is approximately 3 x 10(-10) W/m(2); the ultimate nighttime sensitivity is approximately 3 x 10(-14) W/m(2). Experimental tests were performed to evaluate both dynamic characteristics of this system and the system sensitivity. Dynamic performance of the system was obtained, using a small rocket covered with retroreflective material launched at an acceleration of about 13 g at a point 204 m from the tracker. The daytime sensitivity of the system was checked, using an efficient retroreflector mounted on a light aircraft. This aircraft was tracked out to a maximum range of 15 km, which checked the daytime sensitivity of the system measured by other means. The system also has been used to track passively stars and the Echo I satellite. Also, the system tracked passively a +7.5 magnitude star, and the signal-to-noise ratio in this experiment indicates that it should be possible to track a + 12.5 magnitude star. PMID:20048888

  1. High precision anatomy for MEG.

    PubMed

    Troebinger, Luzia; López, José David; Lutti, Antoine; Bradbury, David; Bestmann, Sven; Barnes, Gareth

    2014-02-01

    Precise MEG estimates of neuronal current flow are undermined by uncertain knowledge of the head location with respect to the MEG sensors. This is either due to head movements within the scanning session or systematic errors in co-registration to anatomy. Here we show how such errors can be minimized using subject-specific head-casts produced using 3D printing technology. The casts fit the scalp of the subject internally and the inside of the MEG dewar externally, reducing within session and between session head movements. Systematic errors in matching to MRI coordinate system are also reduced through the use of MRI-visible fiducial markers placed on the same cast. Bootstrap estimates of absolute co-registration error were of the order of 1mm. Estimates of relative co-registration error were <1.5mm between sessions. We corroborated these scalp based estimates by looking at the MEG data recorded over a 6month period. We found that the between session sensor variability of the subject's evoked response was of the order of the within session noise, showing no appreciable noise due to between-session movement. Simulations suggest that the between-session sensor level amplitude SNR improved by a factor of 5 over conventional strategies. We show that at this level of coregistration accuracy there is strong evidence for anatomical models based on the individual rather than canonical anatomy; but that this advantage disappears for errors of greater than 5mm. This work paves the way for source reconstruction methods which can exploit very high SNR signals and accurate anatomical models; and also significantly increases the sensitivity of longitudinal studies with MEG. PMID:23911673

  2. High precision anatomy for MEG☆

    PubMed Central

    Troebinger, Luzia; López, José David; Lutti, Antoine; Bradbury, David; Bestmann, Sven; Barnes, Gareth

    2014-01-01

    Precise MEG estimates of neuronal current flow are undermined by uncertain knowledge of the head location with respect to the MEG sensors. This is either due to head movements within the scanning session or systematic errors in co-registration to anatomy. Here we show how such errors can be minimized using subject-specific head-casts produced using 3D printing technology. The casts fit the scalp of the subject internally and the inside of the MEG dewar externally, reducing within session and between session head movements. Systematic errors in matching to MRI coordinate system are also reduced through the use of MRI-visible fiducial markers placed on the same cast. Bootstrap estimates of absolute co-registration error were of the order of 1 mm. Estimates of relative co-registration error were < 1.5 mm between sessions. We corroborated these scalp based estimates by looking at the MEG data recorded over a 6 month period. We found that the between session sensor variability of the subject's evoked response was of the order of the within session noise, showing no appreciable noise due to between-session movement. Simulations suggest that the between-session sensor level amplitude SNR improved by a factor of 5 over conventional strategies. We show that at this level of coregistration accuracy there is strong evidence for anatomical models based on the individual rather than canonical anatomy; but that this advantage disappears for errors of greater than 5 mm. This work paves the way for source reconstruction methods which can exploit very high SNR signals and accurate anatomical models; and also significantly increases the sensitivity of longitudinal studies with MEG. PMID:23911673

  3. Precisely parameterized experimental and computational models of tissue organization†

    PubMed Central

    Sekar, Rajesh B.; Blake, Robert; Park, JinSeok; Trayanova, Natalia A.; Tung, Leslie; Levchenko, Andre

    2016-01-01

    Patterns of cellular organization in diverse tissues frequently display a complex geometry and topology tightly related to the tissue function. Progressive disorganization of tissue morphology can lead to pathologic remodeling, necessitating the development of experimental and theoretical methods of analysis of the tolerance of normal tissue function to structural alterations. A systematic way to investigate the relationship of diverse cell organization to tissue function is to engineer two-dimensional cell monolayers replicating key aspects of the in vivo tissue architecture. However, it is still not clear how this can be accomplished on a tissue level scale in a parameterized fashion, allowing for a mathematically precise definition of the model tissue organization and properties down to a cellular scale with a parameter dependent gradual change in model tissue organization. Here, we describe and use a method of designing precisely parameterized, geometrically complex patterns that are then used to control cell alignment and communication of model tissues. We demonstrate direct application of this method to guiding the growth of cardiac cell cultures and developing mathematical models of cell function that correspond to the underlying experimental patterns. Several anisotropic patterned cultures spanning a broad range of multicellular organization, mimicking the cardiac tissue organization of different regions of the heart, were found to be similar to each other and to isotropic cell monolayers in terms of local cell–cell interactions, reflected in similar confluency, morphology and connexin-43 expression. However, in agreement with the model predictions, different anisotropic patterns of cell organization, paralleling in vivo alterations of cardiac tissue morphology, resulted in variable and novel functional responses with important implications for the initiation and maintenance of cardiac arrhythmias. We conclude that variations of tissue geometry and

  4. Precisely parameterized experimental and computational models of tissue organization.

    PubMed

    Molitoris, Jared M; Paliwal, Saurabh; Sekar, Rajesh B; Blake, Robert; Park, JinSeok; Trayanova, Natalia A; Tung, Leslie; Levchenko, Andre

    2016-02-01

    Patterns of cellular organization in diverse tissues frequently display a complex geometry and topology tightly related to the tissue function. Progressive disorganization of tissue morphology can lead to pathologic remodeling, necessitating the development of experimental and theoretical methods of analysis of the tolerance of normal tissue function to structural alterations. A systematic way to investigate the relationship of diverse cell organization to tissue function is to engineer two-dimensional cell monolayers replicating key aspects of the in vivo tissue architecture. However, it is still not clear how this can be accomplished on a tissue level scale in a parameterized fashion, allowing for a mathematically precise definition of the model tissue organization and properties down to a cellular scale with a parameter dependent gradual change in model tissue organization. Here, we describe and use a method of designing precisely parameterized, geometrically complex patterns that are then used to control cell alignment and communication of model tissues. We demonstrate direct application of this method to guiding the growth of cardiac cell cultures and developing mathematical models of cell function that correspond to the underlying experimental patterns. Several anisotropic patterned cultures spanning a broad range of multicellular organization, mimicking the cardiac tissue organization of different regions of the heart, were found to be similar to each other and to isotropic cell monolayers in terms of local cell-cell interactions, reflected in similar confluency, morphology and connexin-43 expression. However, in agreement with the model predictions, different anisotropic patterns of cell organization, paralleling in vivo alterations of cardiac tissue morphology, resulted in variable and novel functional responses with important implications for the initiation and maintenance of cardiac arrhythmias. We conclude that variations of tissue geometry and topology

  5. T1-mapping in the heart: accuracy and precision

    PubMed Central

    2014-01-01

    The longitudinal relaxation time constant (T1) of the myocardium is altered in various disease states due to increased water content or other changes to the local molecular environment. Changes in both native T1 and T1 following administration of gadolinium (Gd) based contrast agents are considered important biomarkers and multiple methods have been suggested for quantifying myocardial T1 in vivo. Characterization of the native T1 of myocardial tissue may be used to detect and assess various cardiomyopathies while measurement of T1 with extracellular Gd based contrast agents provides additional information about the extracellular volume (ECV) fraction. The latter is particularly valuable for more diffuse diseases that are more challenging to detect using conventional late gadolinium enhancement (LGE). Both T1 and ECV measures have been shown to have important prognostic significance. T1-mapping has the potential to detect and quantify diffuse fibrosis at an early stage provided that the measurements have adequate reproducibility. Inversion recovery methods such as MOLLI have excellent precision and are highly reproducible when using tightly controlled protocols. The MOLLI method is widely available and is relatively mature. The accuracy of inversion recovery techniques is affected significantly by magnetization transfer (MT). Despite this, the estimate of apparent T1 using inversion recovery is a sensitive measure, which has been demonstrated to be a useful tool in characterizing tissue and discriminating disease. Saturation recovery methods have the potential to provide a more accurate measurement of T1 that is less sensitive to MT as well as other factors. Saturation recovery techniques are, however, noisier and somewhat more artifact prone and have not demonstrated the same level of reproducibility at this point in time. This review article focuses on the technical aspects of key T1-mapping methods and imaging protocols and describes their limitations including

  6. The Performance Analysis of AN Akf Based Tightly-Coupled Ins/gps Integrated Positioning and Orientation Scheme with Odometer and Non-Holonomic Constraints

    NASA Astrophysics Data System (ADS)

    Peng, K.-Y.; Lin, C.-A.; Chiang, K.-W.

    2012-08-01

    INS/GPS integration scheme can overcome the shortcoming of GPS or INS alone to provide superior performance, thus this study implements a tightly-coupled INS/GPS integration scheme using AKF as the core estimator by tuning the measurement noise matrix R adaptively. The AKF is based on the maximum likelihood criterion for choosing the most appropriate weight and thus the Kalman gain factors. The conventional EKF implementation suffers uncertain results while the update measurement noise matrix R and/or the process noise matrix Q does not meet the case. The primary advantage of AKF is that the filter has less relationship with the priori statistical information because R and/or Q vary with time. The innovation sequence is used to derive the measurement weights through the covariance matrices, innovation-based adaptive estimation (IAE) in this study. The covariance matrices R are adapted in the study when measurements update with time. A window based approach is implemented to update the quality of GPS pseudo-range measurements by adaptively replace the measurement weights through the latest estimated covariance matrices R. The use of odometer is particularly recommended when a low cost and precise vehicle localization system has to be implemented and there is the risk of GPS coverage failure, which is prone to happen when the vehicle enters a tunnel or cross deep valleys. Odometers are applied in land-vehicle navigation to provide augmented host velocity observations for standalone INS system in this study. There are two non-holonomic constraints (NHC) available for land vehicles. Land vehicles will not jump off the ground or slid on the ground under normal condition. Using these constraints, the velocity of the vehicle in the plane perpendicular to the forward direction is almost zero. EKF and AKF based tightly-coupled scheme with NHC is implemented in the study. To validate the performance of AKF based tightly-coupled INS/GPS integration scheme with odometer and

  7. Precision, high dose radiotherapy: helium ion treatment of uveal melanoma

    SciTech Connect

    Saunders, W.M.; Char, D.H.; Quivey, J.M.; Castro, J.R.; Chen, G.T.Y.; Collier, J.M.; Cartigny, A.; Blakely, E.A.; Lyman, J.T.; Zink, S.R.

    1985-02-01

    The authors report on 75 patients with uveal melanoma who were treated by placing the Bragg peak of a helium ion beam over the tumor volume. The technique localizes the high dose region very tightly around the tumor volume. This allows critical structures, such as the optic disc and the macula, to be excluded from the high dose region as long as they are 3 to 4 mm away from the edge of the tumor. Careful attention to tumor localization, treatment planning, patient immobilization and treatment verification is required. With a mean follow-up of 22 months (3 to 60 months) the authors have had only five patients with a local recurrence, all of whom were salvaged with another treatment. Pretreatment visual acuity has generally been preserved as long as the tumor edge is at least 4 mm away from the macula and optic disc. The only serious complication to date has been an 18% incidence of neovascular glaucoma in the patients treated at our highest dose level. Clinical results and details of the technique are presented to illustrate potential clinical precision in administering high dose radiotherapy with charged particles such as helium ions or protons.

  8. Precise numerical estimation of the magnetic field generated around recombination

    NASA Astrophysics Data System (ADS)

    Fidler, Christian; Pettinari, Guido; Pitrou, Cyril

    2016-05-01

    We investigate the generation of magnetic fields from nonlinear effects around recombination. As tight-coupling is gradually lost when approaching z ≃1100 , the velocity difference between photons and baryons starts to increase, leading to an increasing Compton drag of the photons on the electrons. The protons are then forced to follow the electrons due to the electric field created by the charge displacement; the same field, following Maxwell's laws, eventually induces a magnetic field on cosmological scales. Since scalar perturbations do not generate any magnetic field as they are curl-free, one has to resort to second-order perturbation theory to compute the magnetic field generated by this effect. We reinvestigate this problem numerically using the powerful second-order Boltzmann code SONG. We show that: (i) all previous studies do not have a high enough angular resolution to reach a precise and consistent estimation of the magnetic field spectrum; (ii) the magnetic field is generated up to z ≃10 ; (iii) it is in practice impossible to compute the magnetic field with a Boltzmann code for scales smaller than 1 Mpc. Finally we confirm that for scales of a few Mpc, this magnetic field is of order 2 ×10-29 G , many orders of magnitude smaller than what is currently observed on intergalactic scales.

  9. Precision Medicine, Cardiovascular Disease and Hunting Elephants.

    PubMed

    Joyner, Michael J

    2016-01-01

    Precision medicine postulates improved prediction, prevention, diagnosis and treatment of disease based on patient specific factors especially DNA sequence (i.e., gene) variants. Ideas related to precision medicine stem from the much anticipated "genetic revolution in medicine" arising seamlessly from the human genome project (HGP). In this essay I deconstruct the concept of precision medicine and raise questions about the validity of the paradigm in general and its application to cardiovascular disease. Thus far precision medicine has underperformed based on the vision promulgated by enthusiasts. While niche successes for precision medicine are likely, the promises of broad based transformation should be viewed with skepticism. Open discussion and debate related to precision medicine are urgently needed to avoid misapplication of resources, hype, iatrogenic interventions, and distraction from established approaches with ongoing utility. Failure to engage in such debate will lead to negative unintended consequences from a revolution that might never come. PMID:26902518

  10. Interactions between science and precision engineering

    NASA Astrophysics Data System (ADS)

    Atkinson, D. P.; McClure, E. R.; Saito, T. T.

    1987-11-01

    The history of scientific progress is intertwined intimately with precision engineering. Precision engineering and science have synergistically interacted in stimulating each other to significant advances. Furthermore, tangible benefits to the quality of human life, through often unexpected industrial applications, occur. High energy lasers, astrophysical telescopes, and anamorphic optics, along with developments in ultraprecision machining and measurement, are discussed as examples of evolution in science and precision engineering. Possibilities for ultimate by-products for mankind's welfare are explored.

  11. [Precision stomatology: current status and challenges].

    PubMed

    Xu, Xin; Zheng, Xin; Zheng, Liwei; Cheng, Lei; Zhou, Xuedong

    2015-06-01

    The completion of human genome project and the progress in medical practice have inevitably lead to the development of precision medicine, which is a medical model that proposes the customization of medical care including medical decisions, practices, and/or medical products with patient's genetic background, environmental factors and life behavior being taken into account. The current work proposed precision stomatology for the first time, and by integrating data reported in recent literature, we described the current practice of precision stomatology in multiple disciplines in modem dentistry. The clinical significance of precision stomatology and its future challenges have also been discussed. PMID:26281265

  12. Learning to Form a Spatial Category of Tight-Fit Relations: How Experience with a Label Can Give a Boost

    ERIC Educational Resources Information Center

    Casasola, Marianella; Bhagwat, Jui; Burke, Anne S.

    2009-01-01

    Two experiments explored the ability of 18-month-old infants to form an abstract categorical representation of tight-fit spatial relations in a visual habituation task. In Experiment 1, infants formed an abstract spatial category when hearing a familiar word ("tight") during habituation but not when viewing the events in silence or when hearing a…

  13. Caveolin-1–dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo

    PubMed Central

    Marchiando, Amanda M.; Shen, Le; Graham, W. Vallen; Weber, Christopher R.; Schwarz, Brad T.; Austin, Jotham R.; Raleigh, David R.; Guan, Yanfang; Watson, Alastair J.M.; Montrose, Marshall H.

    2010-01-01

    Epithelial paracellular barrier function, determined primarily by tight junction permeability, is frequently disrupted in disease. In the intestine, barrier loss can be mediated by tumor necrosis factor (α) (TNF) signaling and epithelial myosin light chain kinase (MLCK) activation. However, TNF induces only limited alteration of tight junction morphology, and the events that couple structural reorganization to barrier regulation have not been defined. We have used in vivo imaging and transgenic mice expressing fluorescent-tagged occludin and ZO-1 fusion proteins to link occludin endocytosis to TNF-induced tight junction regulation. This endocytosis requires caveolin-1 and is essential for structural and functional tight junction regulation. These data demonstrate that MLCK activation triggers caveolin-1–dependent endocytosis of occludin to effect structural and functional tight junction regulation. PMID:20351069

  14. Corrections to the knife-edge based reconstruction scheme of tightly focused light beams.

    PubMed

    Huber, C; Orlov, S; Banzer, P; Leuchs, G

    2013-10-21

    The knife-edge method is an established technique for profiling light beams. It was shown, that this technique even works for tightly focused beams, if the material and geometry of the probing knife-edges are chosen carefully. Furthermore, it was also reported recently that this method fails, when the knife-edges are made from pure materials. The artifacts introduced in the reconstructed beam shape and position depend strongly on the edge and input beam parameters, because the knife-edge is excited by the incoming beam. Here we show, that the actual beam shape and spot size of tightly focused beams can still be derived from knife-edge measurements for pure edge materials and different edge thicknesses by adapting the analysis method of the experimental data taking into account the interaction of the beam with the edge. PMID:24150349

  15. Tight-binding calculation studies of vacancy and adatom defects in graphene

    DOE PAGESBeta

    Zhang, Wei; Lu, Wen-Cai; Zhang, Hong-Xing; Ho, K. M.; Wang, C. Z.

    2016-02-19

    Computational studies of complex defects in graphene usually need to deal with a larger number of atoms than the current first-principles methods can handle. We show a recently developed three-center tight-binding potential for carbon is very efficient for large scale atomistic simulations and can accurately describe the structures and energies of various defects in graphene. Using the three-center tight-binding potential, we have systematically studied the stable structures and formation energies of vacancy and embedded-atom defects of various sizes up to 4 vacancies and 4 embedded atoms in graphene. In conclusion, our calculations reveal low-energy defect structures and provide a moremore » comprehensive understanding of the structures and stability of defects in graphene.« less

  16. A remotely operated serial sampler for collecting gas-tight fluid samples

    NASA Astrophysics Data System (ADS)

    Wu, Shi-jun; Yang, Can-jun; Ding, Kang; Tan, Chun-yang

    2015-10-01

    This paper describes the design, construction and preliminary test results for a gas-tight serial sampler intended to be deployed at seafloor for long-term operation to take time-series fluid samples from deep-sea environments such as cold seeps, water column and hydrothermal vents. The serial sampler is a modular system that is based on independent and identical sampling modules, which are designed to collect six 160 ml gas-tight fluid samples maintained at high pressure to a depth of 4000 meters. With two working modes, the sampler can be deployed either with seafloor cabled observatory for remote control or as a stand-alone device for autonomous operation. A prototype of the instrument has been constructed and tested on the MARS cabled observatory for two months. The laboratory and field tests proved the success of the design and construction of the serial sampler, and indicated the potential for future ocean sciences.

  17. Fluid identification in tight sandstone reservoirs based on a new rock physics model

    NASA Astrophysics Data System (ADS)

    Sun, Jianmeng; Wei, Xiaohan; Chen, Xuelian

    2016-08-01

    To identify pore fluids, we establish a new rock physics model named the tight sandstone dual-porosity model based on the Voigt–Reuss–Hill model, approximation for the Xu–White model and Gassmann’s equation to predict elastic wave velocities. The modeling test shows that predicted sonic velocities derived from this rock physics model match well with measured ones from logging data. In this context, elastic moduli can be derived from the model. By numerical study and characteristic analyzation of different elastic properties, a qualitative fluid identification method based on Poisson’s ratio and the S–L dual-factor method based on synthetic moduli is proposed. Case studies of these two new methods show the applicability in distinguishing among different fluids and different layers in tight sandstone reservoirs.

  18. Tight-binding model for amine-terminated oligophenyl molecular junctions formed with carbon electrodes

    NASA Astrophysics Data System (ADS)

    Kim, Deok Hyeon; Kim, Taekyeong

    2015-05-01

    We measured the conductance of a series of amine-terminated oligophenyl molecular junction formed with carbon electrodes by using a scanning tunneling microscope based break-junction technique. The tight-binding model that includes the molecular backbone states accurately captured the experimentally measured the molecular conductance and the exponential decay trend of the conductance with the molecular backbone length. Furthermore, we found that this model tracked successfully the shift of the highest occupied molecular orbital toward the Fermi energy as increasing the molecular length. Finally, we found that the tight-binding model explaining more week coupling strength with the graphite electrode than that with the Au electrode is in quantitative agreement with the density functional theory calculations.

  19. Nearest neighbor tight binding models with an exact mobility edge in one dimension.

    PubMed

    Ganeshan, Sriram; Pixley, J H; Das Sarma, S

    2015-04-10

    We investigate localization properties in a family of deterministic (i.e., no disorder) nearest neighbor tight binding models with quasiperiodic on site modulation. We prove that this family is self-dual under a generalized duality transformation. The self-dual condition for this general model turns out to be a simple closed form function of the model parameters and energy. We introduce the typical density of states as an order parameter for localization in quasiperiodic systems. By direct calculations of the inverse participation ratio and the typical density of states we numerically verify that this self-dual line indeed defines a mobility edge in energy separating localized and extended states. Our model is a first example of a nearest neighbor tight binding model manifesting a mobility edge protected by a duality symmetry. We propose a realistic experimental scheme to realize our results in atomic optical lattices and photonic waveguides. PMID:25910146

  20. Tight junction between endothelial cells: the interaction between nanoparticles and blood vessels

    PubMed Central

    Zhang, Yue

    2016-01-01

    Summary Since nanoparticles are now widely applied as food additives, in cosmetics and other industries, especially in medical therapy and diagnosis, we ask here whether nanoparticles can cause several adverse effects to human health. In this review, based on research on nanotoxicity, we mainly discuss the negative influence of nanoparticles on blood vessels in several aspects and the potential mechanism for nanoparticles to penetrate endothelial layers of blood vessels, which are the sites of phosphorylation of tight junction proteins (claudins, occludins, and ZO (Zonula occludens)) proteins, oxidative stress and shear stress. We propose a connection between the presence of nanoparticles and the regulation of the tight junction, which might be the key approach for nanoparticles to penetrate endothelial layers and then have an impact on other tissues and organs. PMID:27335757

  1. Meralgia paresthetica: a result of tight new trendy low cut trousers ('taille basse').

    PubMed

    Moucharafieh, Ramzi; Wehbe, Joseph; Maalouf, Ghassan

    2008-04-01

    Meralgia paresthetica is an entrapment neuropathy involving the lateral femoral cutaneous nerve of the thigh. Patients complain of a persistent burning sensation, tingling and aching pain, and hypersensitivity or hyposensitivity in the anterolateral aspect of the thigh. Numerous direct and indirect causes for the disease have been suggested in the literature. We present 12 cases that were diagnosed to have meralgia paresthetica due to tight new fashion low cut trousers ('taille basse'). The diagnosis was confirmed by injecting a small amount of a short acting local anesthetic around the lateral femoral cutaneous nerve which alleviated the symptoms for several hours. Electrophysiologic studies were sensitive in 83.3% of the cases. All cases were treated successfully using conservative methods, namely avoiding tight trousers, local steroid infiltration and weight reduction. PMID:17521975

  2. Extended Lagrangian Density Functional Tight-Binding Molecular Dynamics for Molecules and Solids

    DOE PAGESBeta

    Aradi, Bálint; Niklasson, Anders M. N.; Frauenheim, Thomas

    2015-06-26

    A computationally fast quantum mechanical molecular dynamics scheme using an extended Lagrangian density functional tight-binding formulation has been developed and implemented in the DFTB+ electronic structure program package for simulations of solids and molecular systems. The scheme combines the computational speed of self-consistent density functional tight-binding theory with the efficiency and long-term accuracy of extended Lagrangian Born–Oppenheimer molecular dynamics. Furthermore, for systems without self-consistent charge instabilities, only a single diagonalization or construction of the single-particle density matrix is required in each time step. The molecular dynamics simulation scheme can also be applied to a broad range of problems in materialsmore » science, chemistry, and biology.« less

  3. Tight junction between endothelial cells: the interaction between nanoparticles and blood vessels.

    PubMed

    Zhang, Yue; Yang, Wan-Xi

    2016-01-01

    Since nanoparticles are now widely applied as food additives, in cosmetics and other industries, especially in medical therapy and diagnosis, we ask here whether nanoparticles can cause several adverse effects to human health. In this review, based on research on nanotoxicity, we mainly discuss the negative influence of nanoparticles on blood vessels in several aspects and the potential mechanism for nanoparticles to penetrate endothelial layers of blood vessels, which are the sites of phosphorylation of tight junction proteins (claudins, occludins, and ZO (Zonula occludens)) proteins, oxidative stress and shear stress. We propose a connection between the presence of nanoparticles and the regulation of the tight junction, which might be the key approach for nanoparticles to penetrate endothelial layers and then have an impact on other tissues and organs. PMID:27335757

  4. Accurate tight-binding Hamiltonians for two-dimensional and layered materials

    NASA Astrophysics Data System (ADS)

    Agapito, Luis A.; Fornari, Marco; Ceresoli, Davide; Ferretti, Andrea; Curtarolo, Stefano; Nardelli, Marco Buongiorno

    2016-03-01

    We present a scheme to controllably improve the accuracy of tight-binding Hamiltonian matrices derived by projecting the solutions of plane-wave ab initio calculations on atomic-orbital basis sets. By systematically increasing the completeness of the basis set of atomic orbitals, we are able to optimize the quality of the band-structure interpolation over wide energy ranges including unoccupied states. This methodology is applied to the case of interlayer and image states, which appear several eV above the Fermi level in materials with large interstitial regions or surfaces such as graphite and graphene. Due to their spatial localization in the empty regions inside or outside of the system, these states have been inaccessible to traditional tight-binding models and even to ab initio calculations with atom-centered basis functions.

  5. Relevant multi-setting tight Bell inequalities for qubits and qutrits

    NASA Astrophysics Data System (ADS)

    Deng, Dong-Ling; Zhou, Zi-Sui; Chen, Jing-Ling

    2009-09-01

    In the celebrated paper [D. Collins, N. Gisin, J. Phys. A Math. Gen. 37 (2004) 1775], Collins and Gisin presented for the first time a three-setting Bell inequality (here we call it CG inequality for simplicity) which is relevant to the Clauser-Horne-Shimony-Holt (CHSH) inequality. Inspired by their brilliant ideas, we obtained some multi-setting tight Bell inequalities, which are relevant to the CHSH inequality and the CG inequality. Moreover, we generalized the method in the paper [J.L. Chen, D.L. Deng, Phys. Rev. A 79 (2009) 012115] to construct Bell inequality for qubits to higher dimensional system. Based on the generalized method, we present, for the first time, a three-setting tight Bell inequality for two qutrits, which is maximally violated by nonmaximally entangled states and relevant to the Collins-Gisin-Linden-Massar-Popescu inequality.

  6. Extended Lagrangian Density Functional Tight-Binding Molecular Dynamics for Molecules and Solids

    SciTech Connect

    Aradi, Bálint; Niklasson, Anders M. N.; Frauenheim, Thomas

    2015-06-26

    A computationally fast quantum mechanical molecular dynamics scheme using an extended Lagrangian density functional tight-binding formulation has been developed and implemented in the DFTB+ electronic structure program package for simulations of solids and molecular systems. The scheme combines the computational speed of self-consistent density functional tight-binding theory with the efficiency and long-term accuracy of extended Lagrangian Born–Oppenheimer molecular dynamics. Furthermore, for systems without self-consistent charge instabilities, only a single diagonalization or construction of the single-particle density matrix is required in each time step. The molecular dynamics simulation scheme can also be applied to a broad range of problems in materials science, chemistry, and biology.

  7. The tight junction protein CAR regulates cardiac conduction and cell–cell communication

    PubMed Central

    Lisewski, Ulrike; Shi, Yu; Wrackmeyer, Uta; Fischer, Robert; Chen, Chen; Schirdewan, Alexander; Jüttner, Rene; Rathjen, Fritz; Poller, Wolfgang; Radke, Michael H.; Gotthardt, Michael

    2008-01-01

    The Coxsackievirus-adenovirus receptor (CAR) is known for its role in virus uptake and as a protein of the tight junction. It is predominantly expressed in the developing brain and heart and reinduced upon cardiac remodeling in heart disease. So far, the physiological functions of CAR in the adult heart are largely unknown. We have generated a heart-specific inducible CAR knockout (KO) and found impaired electrical conduction between atrium and ventricle that increased with progressive loss of CAR. The underlying mechanism relates to the cross talk of tight and gap junctions with altered expression and localization of connexins that affect communication between CAR KO cardiomyocytes. Our results indicate that CAR is not only relevant for virus uptake and cardiac remodeling but also has a previously unknown function in the propagation of excitation from the atrium to the ventricle that could explain the association of arrhythmia and Coxsackievirus infection of the heart. PMID:18794341

  8. Relevant multi-setting tight Bell inequalities for qubits and qutrits

    SciTech Connect

    Deng Dongling; Zhou Zisui; Chen Jingling

    2009-09-15

    In the celebrated paper [D. Collins, N. Gisin, J. Phys. A Math. Gen. 37 (2004) 1775], Collins and Gisin presented for the first time a three-setting Bell inequality (here we call it CG inequality for simplicity) which is relevant to the Clauser-Horne-Shimony-Holt (CHSH) inequality. Inspired by their brilliant ideas, we obtained some multi-setting tight Bell inequalities, which are relevant to the CHSH inequality and the CG inequality. Moreover, we generalized the method in the paper [J.L. Chen, D.L. Deng, Phys. Rev. A 79 (2009) 012115] to construct Bell inequality for qubits to higher dimensional system. Based on the generalized method, we present, for the first time, a three-setting tight Bell inequality for two qutrits, which is maximally violated by nonmaximally entangled states and relevant to the Collins-Gisin-Linden-Massar-Popescu inequality.

  9. Band structure and electron-phonon coupling in H3S : A tight-binding model

    NASA Astrophysics Data System (ADS)

    Ortenzi, L.; Cappelluti, E.; Pietronero, L.

    2016-08-01

    We present a robust tight-binding description, based on the Slater-Koster formalism, of the band structure of H3S in the Im3 ¯m structure, stable in the range of pressure P =180 -220 GPa. We show that the interatomic hopping between the 3 s and 3 p orbitals (and partially between the 3 p orbitals themselves) of sulfur is fundamental to capturing the relevant physics associated with the Van Hove singularities close to the Fermi level. Comparing the model so defined with density functional theory calculations we obtain a very good agreement not only of the overall band structure but also of the low-energy states and the Fermi surface properties. The description in terms of Slater-Koster parameters permits us also to evaluate at a microscopic level a hopping-resolved linear electron-lattice coupling which can be employed for further tight-binding analyses also at a local scale.

  10. Evaluation of indoor air composition time variation in air-tight occupied spaces during night periods

    NASA Astrophysics Data System (ADS)

    Markov, Detelin

    2012-11-01

    This paper presents an easy-to-understand procedure for prediction of indoor air composition time variation in air-tight occupied spaces during the night periods. The mathematical model is based on the assumptions for homogeneity and perfect mixing of the indoor air, the ideal gas model for non-reacting gas mixtures, mass conservation equations for the entire system and for each species, a model for prediction of basal metabolic rate of humans as well as a model for prediction of O2 consumption rate and both CO2 and H2O generation rates by breathing. Time variation of indoor air composition is predicted at constant indoor air temperature for three scenarios based on the analytical solution of the mathematical model. The results achieved reveal both the most probable scenario for indoor air time variation in air-tight occupied spaces as well as the cause for morning tiredness after having a sleep in a modern energy efficient space.

  11. Estimation of Permeability from NMR Logs Based on Formation Classification Method in Tight Gas Sands

    NASA Astrophysics Data System (ADS)

    Wei, Deng-Feng; Liu, Xiao-Peng; Hu, Xiao-Xin; Xu, Rui; Zhu, Ling-Ling

    2015-10-01

    The Schlumberger Doll Research (SDR) model and cross plot of porosity versus permeability cannot be directly used in tight gas sands. In this study, the HFU approach is introduced to classify rocks, and determine the involved parameters in the SDR model. Based on the difference of FZI, 87 core samples, drilled from tight gas sandstones reservoirs of E basin in northwest China and applied for laboratory NMR measurements, were classified into three types, and the involved parameters in the SDR model are calibrated separately. Meanwhile, relationships of porosity versus permeability are also established. The statistical model is used to calculate consecutive FZI from conventional logs. Field examples illustrate that the calibrated SDR models are applicable in permeability estimation; models established from routine core analyzed results are effective in reservoirs with permeability lower than 0.3 mD, while the unified SDR model is only valid in reservoirs with permeability ranges from 0.1 to 0.3 mD.

  12. Nanoscale rotary apparatus formed from tight-fitting 3D DNA components

    PubMed Central

    Ketterer, Philip; Willner, Elena M.; Dietz, Hendrik

    2016-01-01

    We report a nanoscale rotary mechanism that reproduces some of the dynamic properties of biological rotary motors in the absence of an energy source, such as random walks on a circle with dwells at docking sites. Our mechanism is built modularly from tight-fitting components that were self-assembled using multilayer DNA origami. The apparatus has greater structural complexity than previous mechanically interlocked objects and features a well-defined angular degree of freedom without restricting the range of rotation. We studied the dynamics of our mechanism using single-particle experiments analogous to those performed previously with actin-labeled adenosine triphosphate synthases. In our mechanism, rotor mobility, the number of docking sites, and the dwell times at these sites may be controlled through rational design. Our prototype thus realizes a working platform toward creating synthetic nanoscale rotary motors. Our methods will support creating other complex nanoscale mechanisms based on tightly fitting, sterically constrained, but mobile, DNA components. PMID:26989778

  13. Nanoscale rotary apparatus formed from tight-fitting 3D DNA components.

    PubMed

    Ketterer, Philip; Willner, Elena M; Dietz, Hendrik

    2016-02-01

    We report a nanoscale rotary mechanism that reproduces some of the dynamic properties of biological rotary motors in the absence of an energy source, such as random walks on a circle with dwells at docking sites. Our mechanism is built modularly from tight-fitting components that were self-assembled using multilayer DNA origami. The apparatus has greater structural complexity than previous mechanically interlocked objects and features a well-defined angular degree of freedom without restricting the range of rotation. We studied the dynamics of our mechanism using single-particle experiments analogous to those performed previously with actin-labeled adenosine triphosphate synthases. In our mechanism, rotor mobility, the number of docking sites, and the dwell times at these sites may be controlled through rational design. Our prototype thus realizes a working platform toward creating synthetic nanoscale rotary motors. Our methods will support creating other complex nanoscale mechanisms based on tightly fitting, sterically constrained, but mobile, DNA components. PMID:26989778

  14. Single attosecond pulse generation by nonlinear Thomson scattering in a tightly focused intense laser beam

    SciTech Connect

    Lan Pengfei; Lu Peixiang; Cao Wei

    2006-01-15

    The relativistic nonlinear Thomson scattering of a tightly focused intense laser pulse by an electron is investigated, and the temporal and spectral characters of the radiation are discussed. In a tightly focused laser pulse with an intensity of approximately 10{sup 20} W/cm{sup 2} and a pulse duration of 20 fs, the electron is scattered away from the focus quickly by the ponderomotive force and therefore the radiation emitted at the focus is much higher than that at other regions. As a result, a single ultrashort pulse of 3.8 as is generated and its corresponding spectrum is broadened to 200 orders of the frequency of the driving laser. With increasing the laser intensity, the signal-to-noise of the radiated pulse increases, and the pulse duration decreases. Moreover, the phase behavior of the spectral components and the dependence of the radiated power on the laser intensity are discussed.

  15. Application of the Feshbach-resonance management to a tightly confined Bose-Einstein condensate

    NASA Astrophysics Data System (ADS)

    Filatrella, G.; Malomed, B. A.; Salasnich, L.

    2009-04-01

    We study suppression of the collapse and stabilization of matter-wave solitons by means of time-periodic modulation of the effective nonlinearity, using the nonpolynomial Schrödinger equation for Bose-Einstein condensate trapped in a tight cigar-shaped potential. By means of systematic simulations, a stability region is identified in the plane of the modulation amplitude and frequency. In the low-frequency regime, solitons feature chaotic evolution, although they remain robust objects.

  16. Numerical simulation of multi-dimensional NMR response in tight sandstone

    NASA Astrophysics Data System (ADS)

    Guo, Jiangfeng; Xie, Ranhong; Zou, Youlong; Ding, Yejiao

    2016-06-01

    Conventional logging methods have limitations in the evaluation of tight sandstone reservoirs. The multi-dimensional nuclear magnetic resonance (NMR) logging method has the advantage that it can simultaneously measure transverse relaxation time (T 2), longitudinal relaxation time (T 1) and diffusion coefficient (D). In this paper, we simulate NMR measurements of tight sandstone with different wettability and saturations by the random walk method and obtain the magnetization decays of Carr–Purcell–Meiboom–Gill pulse sequences with different wait times (TW) and echo spacings (TE) under a magnetic field gradient, resulting in D-T 2-T 1 maps by the multiple echo trains joint inversion method. We also study the effects of wettability, saturation, signal-to-noise ratio (SNR) of data and restricted diffusion on the D-T 2-T 1 maps in tight sandstone. The results show that with decreasing wetting fluid saturation, the surface relaxation rate of the wetting fluid gradually increases and the restricted diffusion phenomenon becomes more and more obvious, which leads to the wetting fluid signal moving along the direction of short relaxation and the direction of the diffusion coefficient decreasing in D-T 2-T 1 maps. Meanwhile, the non-wetting fluid position in D-T 2-T 1 maps does not change with saturation variation. With decreasing SNR, the ability to identify water and oil signals based on NMR maps gradually decreases. The wetting fluid D-T 1 and D-T 2 correlations in NMR diffusion-relaxation maps of tight sandstone are obtained through expanding the wetting fluid restricted diffusion models, and are further applied to recognize the wetting fluid in simulated D-T 2 maps and D-T 1 maps.

  17. Air tightness of new houses in the U.S.: A preliminary report

    SciTech Connect

    Sherman, Max H.; Matson, Nance E.

    2002-03-01

    Most dwellings in the United States are ventilated primarily through leaks in the building shell (i.e., infiltration) rather than by whole-house mechanical ventilation systems. Consequently, quantification of envelope air-tightness is critical to determining how much energy is being lost through infiltration and how much infiltration is contributing toward ventilation requirements. Envelope air tightness and air leakage can be determined from fan pressurization measurements with a blower door. Tens of thousands of unique fan pressurization measurements have been made of U.S. dwellings over the past decades. LBNL has collected the available data on residential infiltration into its Residential Diagnostics Database, with support from the U.S. Department of Energy. This report documents the envelope air leakage section of the LBNL database, with particular emphasis on new construction. The work reported here is an update of similar efforts carried out a decade ago, which used available data largely focused on the housing stock, rather than on new construction. The current effort emphasizes shell tightness measurements made on houses soon after they are built. These newer data come from over two dozen datasets, including over 73,000 measurements spread throughout a majority of the U.S. Roughly one-third of the measurements are for houses identified as energy-efficient through participation in a government or utility program. As a result, the characteristics reported here provide a quantitative estimate of the impact that energy-efficiency programs have on envelope tightness in the US, as well as on trends in construction.

  18. Secretion of Alpha-Hemolysin by Escherichia coli Disrupts Tight Junctions in Ulcerative Colitis Patients

    PubMed Central

    Mirsepasi-Lauridsen, Hengameh Chloé; Du, Zhengyu; Struve, Carsten; Charbon, Godefroid; Karczewski, Jurgen; Krogfelt, Karen Angeliki; Petersen, Andreas Munk; Wells, Jerry M

    2016-01-01

    Objectives: The potential of Escherichia coli (E. coli) isolated from inflammatory bowel disease (IBD) patients to damage the integrity of the intestinal epithelium was investigated. Methods: E. coli strains isolated from patients with ulcerative colitis (UC) and healthy controls were tested for virulence capacity by molecular techniques and cytotoxic assays and transepithelial electric resistance (TER). E. coli isolate p19A was selected, and deletion mutants were created for alpha-hemolysin (α-hemolysin) (hly) clusters and cytotoxic necrotizing factor type 1 (cnf1). Probiotic E. coli Nissle and pathogenic E. coli LF82 were used as controls. Results: E. coli strains from patients with active UC completely disrupted epithelial cell tight junctions shortly after inoculation. These strains belong to phylogenetic group B2 and are all α-hemolysin positive. In contrast, probiotic E. coli Nissle, pathogenic E. coli LF82, four E. coli from patients with inactive UC and three E. coli strains from healthy controls did not disrupt tight junctions. E. coli p19A WT as well as cnf1, and single loci of hly mutants from cluster I and II were all able to damage Caco-2 (Heterogeneous human epithelial colorectal adenocarcinoma) cell tight junctions. However, this phenotype was lost in a mutant with knockout (Δ) of both hly loci (P<0.001). Conclusions: UC-associated E. coli producing α-hemolysin can cause rapid loss of tight junction integrity in differentiated Caco-2 cell monolayers. This effect was abolished in a mutant unable to express α-hemolysin. These results suggest that high Hly expression may be a mechanism by which specific strains of E. coli pathobionts can contribute to epithelial barrier dysfunction and pathophysiology of disease in IBD. PMID:26938480

  19. Investigating the Relative Permeability of Tight Porous Media Using a Multiscale Network Model

    NASA Astrophysics Data System (ADS)

    Mehmani, A.; Prodanovic, M.

    2013-12-01

    Tight reservoirs, such as tight gas sandstone and tight carbonates, are rich sources of oil and gas that can significantly benefit the high global energy demand. However, the petrophysical properties (such as permeability or capillary pressure) of these so called unconventional reservoirs is difficult to quantify in terms of only porosity or saturation. This is mainly due to the high heterogeneity in pore shape, pore configuration, pore interconnectivity and a lack of understanding of fluid physics within said porous media. One unorthodox petrophysical phenomenon that remains inexplicable via conventional models is what is coined as 'permeability jail' (Shanley et al, 2004). By definition, a permeability jail is a range of water saturation in which neither the wetting phase nor the nonwetting phase is capable of moving. We investigate the effects of fluid physics (snap-off, film flow and wettability) and pore connectivity (pore shape and pore connectivity due to cementation and existence of microporosity) on tight rock relative permeability curves. Pore level modeling has become an established approach in investigating the effects of various pore structure features and fluid behaviors in pore scale on macroscopic petrophysical properties. We construct multiscale pore network flow models that contain both macro- (primary) and microporosity (secondary porosity). We first build theoretical network models based on granular packings to isolate the effects of each pore structure feature as well as fluid physics on both drainage and imbibition relative permeability curves. We then extend our method to imaged media to predict the relative permeability curves of Estaillades limestone based on X-ray microtomography images with identified solid, microporous and pore spaces.

  20. Assessment of unconvential (tight) gas resources in Upper Cook Inlet Basin, South-central Alaska

    USGS Publications Warehouse

    Schenk, Christopher J.; Nelson, Philip H.; Klett, Timothy R.; Le, Phuong A.; Anderson, Christopher P.

    2015-01-01

    A geologic model was developed for the assessment of potential Mesozoic tight-gas resources in the deep, central part of upper Cook Inlet Basin, south-central Alaska. The basic premise of the geologic model is that organic-bearing marine shales of the Middle Jurassic Tuxedni Group achieved adequate thermal maturity for oil and gas generation in the central part of the basin largely due to several kilometers of Paleogene and Neogene burial. In this model, hydrocarbons generated in Tuxedni source rocks resulted in overpressure, causing fracturing and local migration of oil and possibly gas into low-permeability sandstone and siltstone reservoirs in the Jurassic Tuxedni Group and Chinitna and Naknek Formations. Oil that was generated either remained in the source rock and subsequently was cracked to gas which then migrated into low-permeability reservoirs, or oil initially migrated into adjacent low-permeability reservoirs, where it subsequently cracked to gas as adequate thermal maturation was reached in the central part of the basin. Geologic uncertainty exists on the (1) presence of adequate marine source rocks, (2) degree and timing of thermal maturation, generation, and expulsion, (3) migration of hydrocarbons into low-permeability reservoirs, and (4) preservation of this petroleum system. Given these uncertainties and using known U.S. tight gas reservoirs as geologic and production analogs, a mean volume of 0.64 trillion cubic feet of gas was assessed in the basin-center tight-gas system that is postulated to exist in Mesozoic rocks of the upper Cook Inlet Basin. This assessment of Mesozoic basin-center tight gas does not include potential gas accumulations in Cenozoic low-permeability reservoirs.

  1. NF-κB inhibitors impair lung epithelial tight junctions in the absence of inflammation.

    PubMed

    Ward, Christina; Schlingmann, Barbara L; Stecenko, Arlene A; Guidot, David M; Koval, Michael

    2015-01-01

    NF-κB (p50/p65) is the best characterized transcription factor known to regulate cell responses to inflammation. However, NF-κB is also constitutively expressed. We used inhibitors of the classical NF-κB signaling pathway to determine whether this transcription factor has a role in regulating alveolar epithelial tight junctions. Primary rat type II alveolar epithelial cells were isolated and cultured on Transwell permeable supports coated with collagen for 5 d to generate a model type I cell monolayer. Treatment of alveolar epithelial monolayers overnight with one of 2 different IκB kinase inhibitors (BAY 11-7082 or BMS-345541) resulted in a dose-dependent decrease in TER at concentrations that did not affect cell viability. In response to BMS-345541 treatment there was an increase in total claudin-4 and claudin-5 along with a decrease in claudin-18, as determined by immunoblot. However, there was little effect on the total amount of cell-associated claudin-7, occludin, junctional adhesion molecule A (JAM-A), zonula occludens (ZO)-1 or ZO-2. Moreover, treatment with BMS-345541 resulted in altered tight junction morphology as assessed by immunofluorescence microscopy. Cells treated with BMS-345541 had an increase in claudin-18 containing projections emanating from tight junctions ("spikes") that were less prominent in control cells. There also were several areas of cell-cell contact which lacked ZO-1 and ZO-2 localization as well as rearrangements to the actin cytoskeleton in response to BMS-345541. Consistent with an anti-inflammatory effect, BMS-345541 antagonized the deleterious effects of lipopolysaccharide (LPS) on alveolar epithelial barrier function. However, BMS-345541 also inhibited the ability of GM-CSF to increase alveolar epithelial TER. These data suggest a dual role for NF-κB in regulating alveolar barrier function and that constitutive NF-κB function is required for the integrity of alveolar epithelial tight junctions. PMID:25838984

  2. Intraoperative Tight Glucose Control Using Hyperinsulinemic Normoglycemia Increases Delirium After Cardiac Surgery

    PubMed Central

    Saager, Leif; Duncan, Andra E.; Yared, Jean-Pierre; Hesler, Brian D.; You, Jing; Deogaonkar, Anupa; Sessler, Daniel I.; Kurz, Andrea

    2015-01-01

    Background Postoperative delirium is common in patients recovering from cardiac surgery. Tight glucose control has been shown to reduce mortality and morbidity. We therefore sought to determine the effect of tight intraoperative glucose control using a hyper-insulinemic normoglycemic clamp approach on postoperative delirium in patients undergoing cardiac surgery. Methods We enrolled 198 adult patients having cardiac surgery in this randomized, double-blinded single-center trial. Patients were randomly assigned to either tight intraoperative glucose control with a hyperinsulinemic-normoglycemic clamp (target blood glucose: 80–110 mg/dL) or standard therapy (conventional insulin administration with blood glucose target < 150 mg/dL). Delirium was assessed using a comprehensive delirium battery. We considered patients to have experienced postoperative delirium when Confusion Assessment Method testing was positive at any assessment. A positive Confusion Assessment Method test was defined by the presence of features 1 (acute onset and fluctuating course) and 2 (inattention), and either 3 (disorganized thinking) or 4 (altered consciousness). Results Patients randomized to tight glucose control were more likely to be diagnosed as being delirious than those assigned to routine glucose control (26/93 vs. 15/105; Relative Risk (RR), 95% CI: 1.89, 1.06–3.37; P = 0.03), after adjusting for preoperative usage of calcium channel blocker and American Society of Anesthesiologist (ASA) physical status. Delirium severity, among patients with delirium, was comparable with each glucose management strategy. Conclusions Intraoperative hyperinsulinemic-normoglycemia augments the risk of delirium after cardiac surgery, but not its severity. PMID:25992877

  3. Tight-binding vibrational analysis of single-wall carbon nanotubes

    NASA Astrophysics Data System (ADS)

    Beu, Titus A.; Farcaş, Alexandra

    2015-12-01

    The paper presents a detailed normal model analysis of suspended carbon nanotubes, based on a non-orthogonal tight-binding formalism and specialized merit functions to classify the resonance modes. The limit frequencies estimated for macroscopic nanotubes are found in good agreement with previous experimental and theoretical work. The dependence of the resonance vibrations on the nanotube geometry, as well as their appropriateness for mass resonator applications is discussed.

  4. Naturally fractured tight gas reservoir detection optimization. Quarterly report, January 1, 1997--March 31, 1997

    SciTech Connect

    1998-04-01

    This document contains the quarterly report dated January 1-March 31, 1997 for the Naturally Fractured Tight Gas Reservoir Detection Optimization project. Topics covered in this report include AVOA modeling using paraxial ray tracing, AVOA modeling for gas- and water-filled fractures, 3-D and 3-C processing, and technology transfer material. Several presentations from a Geophysical Applications Workshop workbook, workshop schedule, and list of workshop attendees are also included.

  5. Maximal violation of tight Bell inequalities for maximal high-dimensional entanglement

    SciTech Connect

    Lee, Seung-Woo; Jaksch, Dieter

    2009-07-15

    We propose a Bell inequality for high-dimensional bipartite systems obtained by binning local measurement outcomes and show that it is tight. We find a binning method for even d-dimensional measurement outcomes for which this Bell inequality is maximally violated by maximally entangled states. Furthermore, we demonstrate that the Bell inequality is applicable to continuous variable systems and yields strong violations for two-mode squeezed states.

  6. Effects of Soybean Agglutinin on Intestinal Barrier Permeability and Tight Junction Protein Expression in Weaned Piglets

    PubMed Central

    Zhao, Yuan; Qin, Guixin; Sun, Zewei; Che, Dongsheng; Bao, Nan; Zhang, Xiaodong

    2011-01-01

    This study was developed to provide further information on the intestinal barrier permeability and the tight junction protein expression in weaned piglets fed with different levels of soybean agglutinin (SBA). Twenty-five weaned crossbred barrows (Duroc × Landrace × Yorkshire) were selected and randomly allotted to five groups, each group with five replicates. The piglets in the control group were not fed with leguminous products. 0.05, 0.1, 0.15 and 0.2% SBA was added to the control diet to form four experimental diets, respectively. After the experimental period of 7 days (for each group), all the piglets were anesthetized with excess procaine and slaughtered. The d-lactic acid in plasma and the Ileal mucosa diamine oxidase (DAO) was analyzed to observe the change in the intestinal permeability. The tight junction proteins occludin and ZO-1 in the jejunum tissue distribution and relative expression were detected by immunohistochemistry and Western Blot. The results illustrated that a high dose of SBA (0.1–0.2%) could increase the intestinal permeability and reduce piglet intestinal epithelial tight junction protein occludin or ZO-1 expression, while low dose of SBA (0.05% of total diet) had no significant affects. The contents of DAO, d-lactic acid, occludin or ZO-1, had a linear relationship with the SBA levels (0–0.2%) in diets. The high dose SBA (0.1–0.2%) could increase the intestinal permeability and reduce piglet intestinal epithelial tight junction protein occludin or ZO-1 expression, while low dose of SBA (0.05% of total diet) had no affects. PMID:22272087

  7. Detailing the equivalence between real equiangular tight frames and certain strongly regular graphs

    NASA Astrophysics Data System (ADS)

    Fickus, Matthew; Watson, Cody E.

    2015-08-01

    An equiangular tight frame (ETF) is a set of unit vectors whose coherence achieves the Welch bound, and so is as incoherent as possible. They arise in numerous applications. It is well known that real ETFs are equivalent to a certain subclass of strongly regular graphs. In this note, we give some alternative techniques for understanding this equivalence. In a later document, we will use these techniques to further generalize this theory.

  8. Photons and baryons before atoms: Improving the tight-coupling approximation

    NASA Astrophysics Data System (ADS)

    Cyr-Racine, Francis-Yan; Sigurdson, Kris

    2011-05-01

    Prior to recombination photons, electrons, and atomic nuclei rapidly scattered and behaved, almost, like a single tightly-coupled photon-baryon plasma. We investigate here the accuracy of the tight-coupling approximation commonly used to numerically evolve the baryon and photon perturbation equations at early times. By solving the exact perturbations equations with a stiff solver starting deep in the radiation-dominated epoch, we find the level of inaccuracy introduced by resorting to the standard first-order tight-coupling approximation. We develop a new second-order approximation in the inverse Thomson opacity expansion and show that it closely tracks the full solution, at essentially no extra numerical cost. We find the bias on estimates of cosmological parameters introduced by the first-order approximation is, for most parameters, negligible. Finally, we show that our second-order approximation can be used to reduce the time needed to compute cosmic microwave background angular spectra by as much as ˜17%.

  9. Methods for estimating petrophysical parameters from well logs in tight oil reservoirs: a case study

    NASA Astrophysics Data System (ADS)

    Zhao, Peiqiang; Zhuang, Wen; Sun, Zhongchun; Wang, Zhenlin; Luo, Xingping; Mao, Zhiqiang; Tong, Zemin

    2016-02-01

    Estimating petrophysical parameters from well logs plays a significant role in the exploration and development of tight oil resources, but faces challenges. What’s more, the methods for petrophysical parameters from well logs are paid little attention at present. In this paper, the typical tight oil reservoirs of Northwest China are used as an example. Based on the characteristics of mineralogy and fluids in the study field, the rock is assumed into five components which are clays, quartz and feldspar, carbonates, kerogen and pore fluids (porosity). The sum of kerogen content and porosity is defined as the apparent porosity. Then, two porosity log response equations are established. Once the clay content is determined by an individual method, the quartz and feldspar content, carbonate content and apparent porosity are calculated through the established equations. The kerogen content is the difference of the apparent porosity and porosity from nuclear magnetic resonance (NMR) logs. This paper also presents a new approach that combines the complex refractive index method (CRIM) and pseudo Archie method to compute saturation from dielectric logs, which avoids selection for the dielectric constants of each of the minerals. The effectiveness and reliability of these methods are verified by the successful application in the study of the target tight oil play in Northwest China.

  10. Results of Arthroscopy-Assisted TightRope Repair of Acromioclavicular Dislocations

    PubMed Central

    Flinkkilä, Tapio E.; Ihanainen, Essi

    2013-01-01

    Background The present study assessed results of arthroscopy-assisted TightRope (Arthrex, Naples, FL, USA) repair of acute Rockwood grade III and V acromioclavicular (AC) dislocations. Methods We retrospectively reviewed the medical records of 57 patients with AC dislocations treated with TightRope fixation: 15 Rockwood grade III and 42 grade V. Functional results were assessed using the Constant score, and Disabilities of Arm, Shoulder and Hand (DASH) and RAND 36-ltem Health Survey scores after a mean 2.6 years of follow-up (range 1.0 years to 4.5 years). Radiographic results were assessed using the AC joint coracoclavicular (CC) distance. Results Postoperative radiographs showed anatomical AC joint reduction in all patients. In nine patients, fixation failed before 6 weeks postoperatively, mainly as a result of suture breakage. For the remaining 47 patients, CC distance was well maintained at 6 weeks. At follow-up, mean (SD) CC distance was significantly increased compared to the contralateral side or postoperative radiographs [17 (4) mm versus 10 (3) mm]. Mean DASH score was 9, Constant score was 88 and the RAND 36 score showed a quality of life similar to the Finnish reference population. Conclusions Despite initial good reduction of grade III and V AC dislocations using TightRope fixation, subluxation often recurs after 6 weeks. Patients suffer minor subjective complaints that do not worsen the quality of life.

  11. Human alveolar epithelial cells expressing tight junctions to model the air-blood barrier.

    PubMed

    Kuehn, Anna; Kletting, Stephanie; de Souza Carvalho-Wodarz, Cristiane; Repnik, Urska; Griffiths, Gareth; Fischer, Ulrike; Meese, Eckart; Huwer, Hanno; Wirth, Dagmar; May, Tobias; Schneider-Daum, Nicole; Lehr, Claus-Michael

    2016-01-01

    This paper describes a new human alveolar epithelial cell line (hAELVi - human Alveolar Epithelial Lentivirus immortalized) with type I-like characteristics and functional tight junctions, suitable to model the air-blood barrier of the peripheral lung. Primary human alveolar epithelial cells were immortalized by a novel regimen, grown as monolayers on permeable filter supports and characterized morphologically, biochemically and biophysically. hAELVi cells maintain the capacity to form tight intercellular junctions, with high trans-epithelial electrical resistance (> 1000 Ω*cm²). The cells could be kept in culture over several days, up to passage 75, under liquid-liquid as well as air-liquid conditions. Ultrastructural analysis and real time PCR revealed type I-like cell properties, such as the presence of caveolae, expression of caveolin-1, and absence of surfactant protein C. Accounting for the barrier properties, inter-digitations sealed with tight junctions and desmosomes were also observed. Low permeability of the hydrophilic marker sodium fluorescein confirmed the suitability of hAELVi cells for in vitro transport studies across the alveolar epithelium. These results suggest that hAELVi cells reflect the essential features of the air-blood barrier, as needed for an alternative to animal testing to study absorption and toxicity of inhaled drugs, chemicals and nanomaterials. PMID:26985677

  12. Adherens and Tight Junctions: Structure, Function and Connections to the Actin Cytoskeleton

    PubMed Central

    Hartsock, Andrea; Nelson, W. James

    2009-01-01

    Summary Adherens juctions and Tight junctions comprise two modes of cell-cell adhesion that provide different functions. Both junctional complexes are proposed to associate with the actin cytoskeleton, and formation and maturation of cell-cell contacts involves reorganization of the actin cytoskeleton. Adherens junctions initiate cell-cell contacts, and mediate the maturation and maintenance of the contact. Adherens junctions consist of the transmembrane protein E-cadherin, and intracellular components, p120-catenin, β-catenin and α-catenin. Tight junctions regulate the paracellular pathway for the movement of ions and solutes in-between cells. Tight junctions consist of the transmembrane proteins occludin and claudin, and the cytoplasmic scaffolding proteins ZO-1,-2, and -3. This review discusses the binding interactions of the most studied proteins that occur within each of these two junctional complexes and possible modes of regulation of these interactions, and the different mechanisms that connect and regulate interactions with the actin cytoskeleton. PMID:17854762

  13. Use of the Mini TightRope® for correction of hallux varus deformity.

    PubMed

    Gerbert, Joshua; Traynor, Colin; Blue, Kevin; Kim, Kevin

    2011-01-01

    The flexible form of acquired hallux varus has historically been treated with a number of applicable soft tissue procedures, most of which combine medial capsular release with adjunct procedures aimed at restoring the transverse plane balance of the digit. In this report, a surgical technique for correction of hallux varus that employs the use of an implanted button and suture device, namely the Mini TightRope(®), is described. Rather than relying on the patient's own soft tissues, this device applies tension to anchor the hallux in the proper alignment. The device is easily adjusted during the course of the surgery and readily enables accurate correction of the hallux in the transverse plane. The indications, technical execution, postoperative care, and potential complications related to our use of the Mini TightRope(®) for correction of hallux varus are described, and the case of an adult woman who underwent the procedure for correction of acquired hallux varus is presented. In the authors' experience, the Mini TightRope(®) is a viable option that mimics restoration of the lateral collateral ligaments of the first metatarsophalangeal joint, and we believe this technique to be superior to other soft tissue surgical procedures used to repair flexible hallux varus. PMID:21262578

  14. Loss of PALS1 Expression Leads to Tight Junction and Polarity Defects

    PubMed Central

    Straight, Samuel W.; Shin, Kunyoo; Fogg, Vanessa C.; Fan, Shuling; Liu, Chia-Jen; Roh, Michael; Margolis, Ben

    2004-01-01

    Prior work in our laboratory established a connection between the PALS1/PATJ/CRB3 and Par6/Par3/aPKC protein complexes at the tight junction of mammalian epithelial cells. Utilizing a stable small interfering RNA expression system, we have markedly reduced expression of the tight junction-associated protein PALS1 in MDCKII cells. The loss of PALS1 resulted in a corresponding loss of expression of PATJ, a known binding partner of PALS1, but had no effect on the expression of CRB3. However, the absence of PALS1 and PATJ expression did result in the decreased association of CRB3 with members of the Par6/Par3/aPKC protein complex. The consequences of the loss of PALS1 and PATJ were exhibited by a delay in the polarization of MDCKII monolayers after calcium switch, a decrease in the transepithelial electrical resistance, and by the inability of these cells to form lumenal cysts when grown in a collagen gel matrix. These defects in polarity determination may be the result of the lack of recruitment of aPKC to the tight junction in PALS1-deficient cells, as observed by confocal microscopy, and subsequent alterations in downstream signaling events. PMID:14718565

  15. Tight Coupling of Na+/K+-ATPase with Glycolysis Demonstrated in Permeabilized Rat Cardiomyocytes

    PubMed Central

    Sepp, Mervi; Sokolova, Niina; Jugai, Svetlana; Mandel, Merle; Peterson, Pearu; Vendelin, Marko

    2014-01-01

    The effective integrated organization of processes in cardiac cells is achieved, in part, by the functional compartmentation of energy transfer processes. Earlier, using permeabilized cardiomyocytes, we demonstrated the existence of tight coupling between some of cardiomyocyte ATPases and glycolysis in rat. In this work, we studied contribution of two membrane ATPases and whether they are coupled to glycolysis - sarcoplasmic reticulum Ca2+ ATPase (SERCA) and plasmalemma Na+/K+-ATPase (NKA). While SERCA activity was minor in this preparation in the absence of calcium, major role of NKA was revealed accounting to ∼30% of the total ATPase activity which demonstrates that permeabilized cell preparation can be used to study this pump. To elucidate the contribution of NKA in the pool of ATPases, a series of kinetic measurements was performed in cells where NKA had been inhibited by 2 mM ouabain. In these cells, we recorded: ADP- and ATP-kinetics of respiration, competition for ADP between mitochondria and pyruvate kinase (PK), ADP-kinetics of endogenous PK, and ATP-kinetics of total ATPases. The experimental data was analyzed using a series of mathematical models with varying compartmentation levels. The results show that NKA is tightly coupled to glycolysis with undetectable flux of ATP between mitochondria and NKA. Such tight coupling of NKA to PK is in line with its increased importance in the pathological states of the heart when the substrate preference shifts to glucose. PMID:24932585

  16. The cultural dimension of tightness-looseness: An analysis of situational constraint in Estonia and Greece.

    PubMed

    Realo, Anu; Linnamägi, Karmen; Gelfand, Michele J

    2015-06-01

    The importance of tightness-looseness as a dimension that explains a considerable amount of variance between cultures was demonstrated by Gelfand et al. (2011). Tight nations have many strong norms and a low tolerance of deviant behaviour, whereas loose nations have weak social norms and a high tolerance of deviant behaviour. The main aim of the current studies was to examine situational constraint in Estonia and Greece: that is, how the cultural dimension of tightness-looseness is manifested in everyday situations in those two countries. The findings of a questionnaire study (Study 1) suggested that, in general, there is higher constraint across everyday situations in Greece than in Estonia, but situational constraint in Greece is especially strong in school and organisational settings where people have hierarchically structured roles. The results of an observational study (Study 2) revealed a relatively high agreement between appropriateness of certain behaviours as judged by the respondents in Study 1 and the frequencies of observed behaviours in the two countries. Our findings suggest that the strength of situations may substantially vary both within and across cultures, and that the attitudes of the members about situational strength in their respective cultures are in concordance with observations of situations by neutral observers in how people in general behave in their culture. PMID:25130924

  17. Applications of fluorescence microscopy to study of pores in tight rocks

    SciTech Connect

    Soeder, D.J. )

    1990-01-01

    Observation of pore structures in thin section by traditional impregnation with blue-dyed epoxy becomes difficult when the pores are smaller than about 1 {mu}m and/or linear in shape. These types of pores are common in many low-permeability gas reservoirs, such as coal, shale, and tight sandstone. Incident-light fluorescence microscopy can be used to observe small, narrow pore structures in tight rocks. This common medical technique can be adapted to petrography by staining the impregnation epoxy with fluorescent rhodamine B dye along with the usual blue dye, and using an incident-light microscope equipped for epifluorescence to observe the prepared thin section. Under excitation of green light at a wavelength of 5,400 {angstrom}, rhodamine fluoresces a brilliant reddish orange, clearly showing impregnated pore spaces. A dichromatic interference filter in the light path passes the reddish orange light and blocks nonfluorescing mineral grains so that only the pore structure is visible. Fluorescing epoxy behaves as an emission source, and even submicron-size pores, which may be narrower than the wavelengths of visible light, become visible if they are impregnated. The incident-light configuration of the microscope also allows the observation of impregnated pore spaces in opaque materials such as coal. Fluorescence microscopy not only has potential for studying pore structures in tight sedimentary rocks, but also can be applied to crystalline rocks and other materials with narrow, linear, or small pores. 9 figs.

  18. Group A Streptococcus exploits human plasminogen for bacterial translocation across epithelial barrier via tricellular tight junctions

    PubMed Central

    Sumitomo, Tomoko; Nakata, Masanobu; Higashino, Miharu; Yamaguchi, Masaya; Kawabata, Shigetada

    2016-01-01

    Group A Streptococcus (GAS) is a human-specific pathogen responsible for local suppurative and life-threatening invasive systemic diseases. Interaction of GAS with human plasminogen (PLG) is a salient characteristic for promoting their systemic dissemination. In the present study, a serotype M28 strain was found predominantly localized in tricellular tight junctions of epithelial cells cultured in the presence of PLG. Several lines of evidence indicated that interaction of PLG with tricellulin, a major component of tricellular tight junctions, is crucial for bacterial localization. A site-directed mutagenesis approach revealed that lysine residues at positions 217 and 252 within the extracellular loop of tricellulin play important roles in PLG-binding activity. Additionally, we demonstrated that PLG functions as a molecular bridge between tricellulin and streptococcal surface enolase (SEN). The wild type strain efficiently translocated across the epithelial monolayer, accompanied by cleavage of transmembrane junctional proteins. In contrast, amino acid substitutions in the PLG-binding motif of SEN markedly compromised those activities. Notably, the interaction of PLG with SEN was dependent on PLG species specificity, which influenced the efficiency of bacterial penetration. Our findings provide insight into the mechanism by which GAS exploits host PLG for acceleration of bacterial invasion into deeper tissues via tricellular tight junctions. PMID:26822058

  19. ACUTE EFFECTS OF DRY NEEDLING ON POSTERIOR SHOULDER TIGHTNESS. A CASE REPORT

    PubMed Central

    Plebani, Giuseppe; Poser, Antonio

    2016-01-01

    Background and Purpose Posterior shoulder tightness has been associated with numerous shoulder disorders. Methods to increase posterior shoulder mobility may be beneficial. The purpose of this case report is to report the outcomes of a subject with posterior shoulder tightness treated with dry needling as a primary intervention strategy. Case description The subject was a 46-year-old man who was referred to physical therapy with primary symptoms of shoulder pain and loss of motion consistent with subacromial impingement syndrome. Clinical findings upon examination revealed glenohumeral internal rotation and horizontal adduction losses of motion and reproduction of pain symptoms upon palpation of the infraspinatus, teres minor, and posterior deltoid. A single treatment of trigger point dry needling was used to decrease pain and improve range of motion. Outcomes Following the intervention, clinically meaningful improvements were seen in pain and shoulder range of motion. Discussion This case report describes the use of trigger point dry needling in the treatment of a subject with posterior shoulder tightness. The immediate improvement seen in this subject following the dry needling to the infraspinatus, teres minor, and posterior deltoid muscles suggests that muscles may be a significant source of pain and range of motion limitation in this condition. Level of Evidence Level 4 PMID:27104059

  20. OPTIMIZATION OF INFILL DRILLING IN NATURALLY-FRACTURED TIGHT-GAS RESERVOIRS

    SciTech Connect

    Lawrence W. Teufel; Her-Yuan Chen; Thomas W. Engler; Bruce Hart

    2004-05-01

    A major goal of industry and the U.S. Department of Energy (DOE) fossil energy program is to increase gas reserves in tight-gas reservoirs. Infill drilling and hydraulic fracture stimulation in these reservoirs are important reservoir management strategies to increase production and reserves. Phase II of this DOE/cooperative industry project focused on optimization of infill drilling and evaluation of hydraulic fracturing in naturally-fractured tight-gas reservoirs. The cooperative project involved multidisciplinary reservoir characterization and simulation studies to determine infill well potential in the Mesaverde and Dakota sandstone formations at selected areas in the San Juan Basin of northwestern New Mexico. This work used the methodology and approach developed in Phase I. Integrated reservoir description and hydraulic fracture treatment analyses were also conducted in the Pecos Slope Abo tight-gas reservoir in southeastern New Mexico and the Lewis Shale in the San Juan Basin. This study has demonstrated a methodology to (1) describe reservoir heterogeneities and natural fracture systems, (2) determine reservoir permeability and permeability anisotropy, (3) define the elliptical drainage area and recoverable gas for existing wells, (4) determine the optimal location and number of new in-fill wells to maximize economic recovery, (5) forecast the increase in total cumulative gas production from infill drilling, and (6) evaluate hydraulic fracture simulation treatments and their impact on well drainage area and infill well potential. Industry partners during the course of this five-year project included BP, Burlington Resources, ConocoPhillips, and Williams.

  1. Tight-binding models for ultracold atoms in optical lattices: general formulation and applications

    NASA Astrophysics Data System (ADS)

    Modugno, Michele; Ibañez-Azpiroz, Julen; Pettini, Giulio

    2016-06-01

    Tight-binding models for ultracold atoms in optical lattices can be properly defined by using the concept of maximally localized Wannier functions for composite bands. The basic principles of this approach are reviewed here, along with different applications to lattice potentials with two minima per unit cell, in one and two spatial dimensions. Two independent methods for computing the tight-binding coefficients—one ab initio, based on the maximally localized Wannier functions, the other through analytic expressions in terms of the energy spectrum—are considered. In the one dimensional case, where the tight-binding coefficients can be obtained by designing a specific gauge transformation, we consider both the case of quasi resonance between the two lowest bands, and that between s and p orbitals. In the latter case, the role of the Wannier functions in the derivation of an effective Dirac equation is also reviewed. Then, we consider the case of a two dimensional honeycomb potential, with particular emphasis on the Haldane model, its phase diagram, and the breakdown of the Peierls substitution. Tunable honeycomb lattices, characterized by movable Dirac points, are also considered. Finally, general considerations for dealing with the interaction terms are presented.

  2. Headache under simulated microgravity is related to endocrine, fluid distribution, and tight junction changes.

    PubMed

    Feuerecker, Matthias; van Oosterhout, Willebrordus P J; Feuerecker, Benedikt; Matzel, Sandra; Schelling, Gustav; Rehm, Markus; Vein, Alla A; Choukèr, Alexander

    2016-05-01

    Head-down-tilted bed rest (HDTBR) induces headaches similar to headaches during space flights. The objective of this investigation was to study hematological, endocrinological, fluid changes and tight junctions in HDTBR-induced headaches as a proxy for space headache. The randomized crossover HDTBR design by the European Space Agency included 12 healthy, nonheadache male subjects. Before, during, and after confined HDTBR periods, epinephrine (urine), cortisol (saliva), hematological, endothelium markers, and fluid distribution parameters were measured. Headaches were assessed with a validated headache questionnaire. Compared with baseline, HDTBR in all subjects was associated with higher hematocrit, hemoglobin, and epinephrine levels, higher erythrocyte counts, and lower relative plasma volumes (all P < 0.05). In total, 26 headache episodes occurred. In subjects with headaches during HDTBR, epinephrine levels were exaggerated (vs headache-free subjects; HDTBR day 3; 5.1 ± 1.7 vs 3.4 ± 2.4; P = 0.023), cortisol levels were decreased (vs headache-free subjects; HDTBR day 1; 0.37 ± 0.16 vs 0.50 ± 0.20; P < 0.001) and the tight junction marker zonulin was elevated (vs headache-free subjects in HDTBR days 1, 3, 5; P < 0.05). HDTBR induces hemoconcentration and fluid redistribution in all subjects. During headache episodes, endocrinological changes, fluid distribution, and tight junctions were more pronounced, suggesting an additional role in headache pathophysiology. PMID:26761382

  3. Tight binding approach to study electronic properties of MoS2/WS2 heterostructure

    NASA Astrophysics Data System (ADS)

    Narendra, Namita; Kim, Ki Wook

    The heterostructure interface of MoS2/WS2 is being increasingly studied in recent years for its electronic and optical properties. The ability to tune properties of few-layer transition metal dichalcogenides (TMDs) by strain engineering provides a significant incentive to further explore these material interfaces. It has been shown that misorientation in bulk MoS2 and WS2 can also alter the electronic properties. Tight binding allows us to calculate the transport properties of MoS2/WS2 interface for all the angles of misorientation, unlike the computationally limited first principles approach. In this work, the tight binding parameters for the bulk are extracted from first principles and the heterostructure model is verified. A detailed study of variation of electronic properties of MoS2/WS2 interface with respect to addition of strain and number of layers of MoS2 and WS2 is carried out. The extension of tight binding model to misoriented MoS2/WS2 interface is demonstrated.

  4. Anisotropic tight-binding model applied to zigzag ultra-small nanotubes

    NASA Astrophysics Data System (ADS)

    Ribeiro, A. N.; Macedo, C. A.

    2010-04-01

    A single-wall carbon nanotube (SWCNT) can be visualized as a graphene rolled into a cylinder. Tight-binding band structure calculations, with hopping between nearest-neighbor π orbitals only (NNTB), established rules by which both the mode in which the graphene is rolled up and the diameter determine whether the SWCNT is a metal or a semiconductor. However, when the diameter of the SWCNT is ultra-small its large curvature results in the breakage of these rules. In this work, we studied zigzag (n, 0) SWCNTs with diameters smaller than 0.7 nm using a π orbital-only tight-binding model including anisotropy in the hopping between next-nearest-neighbor sites (ANNNTB). Band overlaps were found in the electronic band structures of the zigzag SWCNTs for n=3, 4, 5, and 6, indicating that they are metals. The reason why the band structures of armchair and chiral SWCNTs are less affected by curvature effects becomes clear with the ANNNTB model, as does the reason why non-degenerate states cause band overlaps of the zigzag SWCNTs for n=3, 4, 5, and 6. Our results show that a π orbital-only tight-binding model is able to describe both the band overlaps and gaps obtained by ab initio calculations for zigzag SWCNTs.

  5. Hybrid spherical cap plasmonic waveguide for tight mode confinement and long propagation length

    NASA Astrophysics Data System (ADS)

    Li, Kai; Yun, Maojin; Ge, Xiaohui; Kong, Weijin

    2015-08-01

    The special abilities of plasmonic waveguide including tight field confinement and beyond diffraction limit within nano-scale structure have been exploited in many different fields. In order to overcome the trade-off between tight mode confinement and long propagation length, many kinds of nano-scale structures have been proposed in recent years. In this paper, a novel hybrid plasmonic waveguide consisting of the layer of metal Ag, a spherical cap with low-index dielectric layer placed above the metal Ag and a high-index dielectric layer placed above the spherical cap is proposed and analyzed theoretically. The relations between the characteristics of the bound modes, such as mode confinement, propagation lengths, and parameters of the spherical cap, the curvature and width, are numerically investigated in detail. The simulation results show that the nano-scale confinement can be realized. The simulation result shows that the performance of the proposed spherical cap hybrid plasmonic waveguide is better than the rectangle or cylindrical hybrid plasmonic waveguide. Such hybrid plasmonic waveguide has a tight mode confinement and long propagation length. This novel structure provides a promising application for high-integration density photonic components.

  6. Early failure of coracoclavicular ligament reconstruction using TightRope system.

    PubMed

    Singh, Bijayendra; Mohanlal, Paras; Bawale, Rajesh

    2016-03-01

    This prospective study reports the results of early failure of coracoclavicular (CC) ligament reconstruction using TightRope. Nine consecutive patients who had CC ligament reconstruction using TightRope or GraftRope were assessed for radiological and functional outcomes using DASH and Oxford Shoulder scores. With an average age of 38.4 (21-70) years, four patients had type III injuries, two type IV and two type V injuries. The mean follow-up was 22.8 (12-42) months. In 7 out of 9 patients, secondary progressive loss of reduction was observed at an average of 3.1 (1-7) months. Three patients underwent revision. The mean DASH score at latest follow-up was 27.45 (19.6-35) & Oxford shoulder score was 30.5 (20-43). Coraco-clavicular reconstruction with TightRope or GraftRope appears to result in failure with progressive AC joint subluxation perhaps due to 'windscreen wiper' micromotion. Surgeons should be wary of this potential problem whilst choosing this method of -reconstruction for CC ligament reconstructions. PMID:26984664

  7. High-precision analysis of the solar twin HIP 100963

    NASA Astrophysics Data System (ADS)

    Galarza, Jhon Yana; Meléndez, Jorge; Ramírez, Ivan; Yong, David; Karakas, Amanda I.; Asplund, Martin; Liu, Fan

    2016-04-01

    Context. HIP 100963 was one of the first solar twins identified. Although some high-precision analyses are available, a comprehensive high-precision study of chemical elements from different nucleosynthetic sources is still lacking from which to obtain potential new insights on planets, stellar evolution, and Galactic chemical evolution (GCE). Aims: We analyze and investigate the origin of the abundance pattern of HIP 100963 in detail, in particular the pattern of the light element Li, the volatile and refractory elements, and heavy elements from the s- and r-processes. Methods: We used the HIRES spectrograph on the Keck I telescope to acquire high-resolution (R ≈ 70 000) spectra with a high signal-to-noise ratio (S/N ≈ 400-650 per pixel) of HIP 100963 and the Sun for a differential abundance analysis. We measured the equivalent widths (EWs) of iron lines to determine the stellar parameters by employing the differential spectroscopic equilibrium. We determined the composition of volatile, refractory, and neutron-capture elements through a differential abundance analysis with respect to the Sun. Results: The stellar parameters we found are Teff = 5818 ± 4 K, log g = 4.49 ± 0.01 dex, vt = 1.03 ± 0.01km s-1, and [Fe/H] = -0.003 ± 0.004 dex. These low errors allow us to compute a precise mass (1.03+0.02-0.01 M⊙) and age (2.0 ± 0.4 Gyr), obtained using Yonsei-Yale isochrones. Using our [Y/Mg] ratio, we have determined an age of 2.1 ± 0.4 Gyr, in agreement with the age computed using isochrones. Our isochronal age also agrees with the age determined from stellar activity (2.4 ± 0.3 Gyr). We study the abundance pattern with condensation temperature (Tcond) taking corrections by the GCE into account. We show that the enhancements of neutron-capture elements are explained by contributions from both the s- and r-process. The lithium abundance follows the tight Li-age correlation seen in other solar twins. Conclusions: We confirm that HIP 100963 is a solar twin

  8. High-precision analysis of the solar twin HIP 100963

    NASA Astrophysics Data System (ADS)

    Galarza, Jhon Yana; Meléndez, Jorge; Ramírez, Ivan; Yong, David; Karakas, Amanda I.; Asplund, Martin; Liu, Fan

    2016-05-01

    Context. HIP 100963 was one of the first solar twins identified. Although some high-precision analyses are available, a comprehensive high-precision study of chemical elements from different nucleosynthetic sources is still lacking from which to obtain potential new insights on planets, stellar evolution, and Galactic chemical evolution (GCE). Aims: We analyze and investigate the origin of the abundance pattern of HIP 100963 in detail, in particular the pattern of the light element Li, the volatile and refractory elements, and heavy elements from the s- and r-processes. Methods: We used the HIRES spectrograph on the Keck I telescope to acquire high-resolution (R ≈ 70 000) spectra with a high signal-to-noise ratio (S/N ≈ 400-650 per pixel) of HIP 100963 and the Sun for a differential abundance analysis. We measured the equivalent widths (EWs) of iron lines to determine the stellar parameters by employing the differential spectroscopic equilibrium. We determined the composition of volatile, refractory, and neutron-capture elements through a differential abundance analysis with respect to the Sun. Results: The stellar parameters we found are Teff = 5818 ± 4 K, log g = 4.49 ± 0.01 dex, vt = 1.03 ± 0.01km s-1, and [Fe/H] = -0.003 ± 0.004 dex. These low errors allow us to compute a precise mass (1.03+0.02-0.01 M⊙) and age (2.0 ± 0.4 Gyr), obtained using Yonsei-Yale isochrones. Using our [Y/Mg] ratio, we have determined an age of 2.1 ± 0.4 Gyr, in agreement with the age computed using isochrones. Our isochronal age also agrees with the age determined from stellar activity (2.4 ± 0.3 Gyr). We study the abundance pattern with condensation temperature (Tcond) taking corrections by the GCE into account. We show that the enhancements of neutron-capture elements are explained by contributions from both the s- and r-process. The lithium abundance follows the tight Li-age correlation seen in other solar twins. Conclusions: We confirm that HIP 100963 is a solar twin

  9. Developing and implementing a high precision setup system

    NASA Astrophysics Data System (ADS)

    Peng, Lee-Cheng

    The demand for high-precision radiotherapy (HPRT) was first implemented in stereotactic radiosurgery using a rigid, invasive stereotactic head frame. Fractionated stereotactic radiotherapy (SRT) with a frameless device was developed along a growing interest in sophisticated treatment with a tight margin and high-dose gradient. This dissertation establishes the complete management for HPRT in the process of frameless SRT, including image-guided localization, immobilization, and dose evaluation. The most ideal and precise positioning system can allow for ease of relocation, real-time patient movement assessment, high accuracy, and no additional dose in daily use. A new image-guided stereotactic positioning system (IGSPS), the Align RT3C 3D surface camera system (ART, VisionRT), which combines 3D surface images and uses a real-time tracking technique, was developed to ensure accurate positioning at the first place. The uncertainties of current optical tracking system, which causes patient discomfort due to additional bite plates using the dental impression technique and external markers, are found. The accuracy and feasibility of ART is validated by comparisons with the optical tracking and cone-beam computed tomography (CBCT) systems. Additionally, an effective daily quality assurance (QA) program for the linear accelerator and multiple IGSPSs is the most important factor to ensure system performance in daily use. Currently, systematic errors from the phantom variety and long measurement time caused by switching phantoms were discovered. We investigated the use of a commercially available daily QA device to improve the efficiency and thoroughness. Reasonable action level has been established by considering dosimetric relevance and clinic flow. As for intricate treatments, the effect of dose deviation caused by setup errors remains uncertain on tumor coverage and toxicity on OARs. The lack of adequate dosimetric simulations based on the true treatment coordinates from

  10. What can we expect from precision asteroseismology?

    NASA Astrophysics Data System (ADS)

    Handler, G.

    2014-02-01

    Precision asteroseismology is the determination of accurate stellar parameters from oscillation data. At first successful for pulsating white dwarf stars, it is now applied to more and more types of stars. We give a number of selected examples where precision asteroseismology, but also asteroseismology based on few observables may lead to considerable improvement of stellar astrophysics in the near future.

  11. Ultra-precision processes for optics manufacturing

    NASA Astrophysics Data System (ADS)

    Martin, William R.

    1991-12-01

    The Optics MODIL (Manufacturing Operations Development and Integration Laboratory) is developing advanced manufacturing technologies for fabrication of ultra precision optical components, aiming for a ten-fold improvement in precision and a shortening of the scheduled lead time. Current work focuses on diamond single point turning, ductile grinding, ion milling, and in/on process metrology.

  12. Ultra-precision processes for optics manufacturing

    NASA Technical Reports Server (NTRS)

    Martin, William R.

    1991-01-01

    The Optics MODIL (Manufacturing Operations Development and Integration Laboratory) is developing advanced manufacturing technologies for fabrication of ultra precision optical components, aiming for a ten-fold improvement in precision and a shortening of the scheduled lead time. Current work focuses on diamond single point turning, ductile grinding, ion milling, and in/on process metrology.

  13. 21 CFR 872.3165 - Precision attachment.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Precision attachment. 872.3165 Section 872.3165 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES DENTAL DEVICES Prosthetic Devices § 872.3165 Precision attachment. (a) Identification....

  14. Remote sensing applications to precision farming

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Traditional mechanized agriculture treats large fields with uniform agronomic practices. Precision agriculture/precision farming brings a new concept to manage in-field variability with variable rate application of fertilizers and pesticides, site-specific water management, as well as planting, etc....

  15. Visual thread quality for precision miniature mechanisms

    SciTech Connect

    Gillespie, L.K.

    1981-04-01

    Threaded features have eight visual appearance factors which can affect their function in precision miniature mechanisms. The Bendix practice in deburring, finishing, and accepting these conditions on miniature threads is described as is their impact in assemblies of precision miniature electromechanical assemblies.

  16. An aberrant precision account of autism

    PubMed Central

    Lawson, Rebecca P.; Rees, Geraint; Friston, Karl J.

    2014-01-01

    Autism is a neurodevelopmental disorder characterized by problems with social-communication, restricted interests and repetitive behavior. A recent and thought-provoking article presented a normative explanation for the perceptual symptoms of autism in terms of a failure of Bayesian inference (Pellicano and Burr, 2012). In response, we suggested that when Bayesian inference is grounded in its neural instantiation—namely, predictive coding—many features of autistic perception can be attributed to aberrant precision (or beliefs about precision) within the context of hierarchical message passing in the brain (Friston et al., 2013). Here, we unpack the aberrant precision account of autism. Specifically, we consider how empirical findings—that speak directly or indirectly to neurobiological mechanisms—are consistent with the aberrant encoding of precision in autism; in particular, an imbalance of the precision ascribed to sensory evidence relative to prior beliefs. PMID:24860482

  17. STEAM LINE BREAK AND STATION BLACKOUT TRANSIENTS FOR PROLIFERATION RESISTANT HEXAGONAL TIGHT LATTICE BWR.

    SciTech Connect

    ROHATGI,U.S.; JO,J.; CHUNG,B.D.; TAKAHASHI,H.

    2002-06-09

    Safety analyses of a proliferation resistant, economically competitive, high conversion, boiling water reactor (HCBWR) fueled with fissile plutonium and fertile thorium oxide fuel elements, and with passive safety systems are presented here. The HCBWR developed here is characterized by a very tight lattice with a relatively small water volume fraction in the core which therefore operates with a fast reactor neutron spectrum, and a considerably improved neutron economy compared to the current generation of Light Water Reactors. The tight lattice core has a very narrow flow channels with a hydraulic diameter less than half of the regular BWR core and, thus, presents a special challenge to core cooling, because of reduced water inventory and high friction in the core. The primary safety concern when reducing the moderator to fuel ratio and when using a tightly packed lattice arrangement is to maintain adequate cooling of the core during both normal operation and accident scenarios. In the preliminary HCBWR design, the core has been placed in a vessel with a large chimney section, and the vessel is connected with Isolation Condenser System (ICs). The vessel is placed in containment with Gravity Driven Cooling System (GDCS) and Passive Containment Cooling System (PCCS) in a configuration similar to General Electric's Simplified Boiling Water Reactor (SBWR). The safety systems are similar to SBWR; ICs and PCCS are scaled with power. An internal recirculation pump was placed in the downcomer to augment the buoyancy head provided by the chimney, since the buoyancy provided by the chimney alone could not generate sufficient recirculation in the vessel as the tight lattice configuration resulted in much larger friction in the core than the SBWR. The constitutive relationships for RELAP5 were assessed for narrow channels, and as a result the heat transfer package was modified. The modified RELAP5 was used to simulate and analyze two of the most limiting events for a tight

  18. NIH Precision Medicine Initiative | NIH MedlinePlus the Magazine

    MedlinePlus

    ... page please turn JavaScript on. Feature: NIH Precision Medicine Initiative NIH Precision Medicine Initiative Past Issues / Fall 2015 Table of Contents Connections to Precision Medicine Precision medicine is already saving lives. Read the ...

  19. 76 FR 35024 - Precision Dynamics Corporation San Fernando, CA; Precision Dynamics Corporation, Also Known as...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-15

    ... FR 51848). At the request of the company, the Department reviewed the certification for workers of... Employment and Training Administration Precision Dynamics Corporation San Fernando, CA; Precision Dynamics... for Worker Adjustment Assistance on January 28, 2011, applicable to workers of Precision...

  20. Potential evaluation of CO2 storage and enhanced oil recovery of tight oil reservoir in the Ordos Basin, China.

    PubMed

    Tian, Xiaofeng; Cheng, Linsong; Cao, Renyi; Zhang, Miaoyi; Guo, Qiang; Wang, Yimin; Zhang, Jian; Cui, Yu

    2015-07-01

    Carbon -di-oxide (CO2) is regarded as the most important greenhouse gas to accelerate climate change and ocean acidification. The Chinese government is seeking methods to reduce anthropogenic CO2 gas emission. CO2 capture and geological storage is one of the main methods. In addition, injecting CO2 is also an effective method to replenish formation energy in developing tight oil reservoirs. However, exiting methods to estimate CO2 storage capacity are all based on the material balance theory. This was absolutely correct for normal reservoirs. However, as natural fractures widely exist in tight oil reservoirs and majority of them are vertical ones, tight oil reservoirs are not close. Therefore, material balance theory is not adaptive. In the present study, a new method to calculate CO2 storage capacity is presented. The CO2 effective storage capacity, in this new method, consisted of free CO2, CO2 dissolved in oil and CO2 dissolved in water. Case studies of tight oil reservoir from Ordos Basin was conducted and it was found that due to far lower viscosity of CO2 and larger solubility in oil, CO2 could flow in tight oil reservoirs more easily. As a result, injecting CO2 in tight oil reservoirs could obviously enhance sweep efficiency by 24.5% and oil recovery efficiency by 7.5%. CO2 effective storage capacity of Chang 7 tight oil reservoir in Longdong area was 1.88 x 10(7) t. The Chang 7 tight oil reservoir in Ordos Basin was estimated to be 6.38 x 10(11) t. As tight oil reservoirs were widely distributed in Songliao Basin, Sichuan Basin and so on, geological storage capacity of CO2 in China is potential. PMID:26387353

  1. Does precision decrease with set size?

    PubMed Central

    Mazyar, Helga; van den Berg, Ronald; Ma, Wei Ji

    2012-01-01

    The brain encodes visual information with limited precision. Contradictory evidence exists as to whether the precision with which an item is encoded depends on the number of stimuli in a display (set size). Some studies have found evidence that precision decreases with set size, but others have reported constant precision. These groups of studies differed in two ways. The studies that reported a decrease used displays with heterogeneous stimuli and tasks with a short-term memory component, while the ones that reported constancy used homogeneous stimuli and tasks that did not require short-term memory. To disentangle the effects of heterogeneity and short-memory involvement, we conducted two main experiments. In Experiment 1, stimuli were heterogeneous, and we compared a condition in which target identity was revealed before the stimulus display with one in which it was revealed afterward. In Experiment 2, target identity was fixed, and we compared heterogeneous and homogeneous distractor conditions. In both experiments, we compared an optimal-observer model in which precision is constant with set size with one in which it depends on set size. We found that precision decreases with set size when the distractors are heterogeneous, regardless of whether short-term memory is involved, but not when it is homogeneous. This suggests that heterogeneity, not short-term memory, is the critical factor. In addition, we found that precision exhibits variability across items and trials, which may partly be caused by attentional fluctuations. PMID:22685337

  2. Performance Analysis of Several GPS/Galileo Precise Point Positioning Models.

    PubMed

    Afifi, Akram; El-Rabbany, Ahmed

    2015-01-01

    This paper examines the performance of several precise point positioning (PPP) models, which combine dual-frequency GPS/Galileo observations in the un-differenced and between-satellite single-difference (BSSD) modes. These include the traditional un-differenced model, the decoupled clock model, the semi-decoupled clock model, and the between-satellite single-difference model. We take advantage of the IGS-MGEX network products to correct for the satellite differential code biases and the orbital and satellite clock errors. Natural Resources Canada's GPSPace PPP software is modified to handle the various GPS/Galileo PPP models. A total of six data sets of GPS and Galileo observations at six IGS stations are processed to examine the performance of the various PPP models. It is shown that the traditional un-differenced GPS/Galileo PPP model, the GPS decoupled clock model, and the semi-decoupled clock GPS/Galileo PPP model improve the convergence time by about 25% in comparison with the un-differenced GPS-only model. In addition, the semi-decoupled GPS/Galileo PPP model improves the solution precision by about 25% compared to the traditional un-differenced GPS/Galileo PPP model. Moreover, the BSSD GPS/Galileo PPP model improves the solution convergence time by about 50%, in comparison with the un-differenced GPS PPP model, regardless of the type of BSSD combination used. As well, the BSSD model improves the precision of the estimated parameters by about 50% and 25% when the loose and the tight combinations are used, respectively, in comparison with the un-differenced GPS-only model. Comparable results are obtained through the tight combination when either a GPS or a Galileo satellite is selected as a reference. PMID:26102495

  3. Performance Analysis of Several GPS/Galileo Precise Point Positioning Models

    PubMed Central

    Afifi, Akram; El-Rabbany, Ahmed

    2015-01-01

    This paper examines the performance of several precise point positioning (PPP) models, which combine dual-frequency GPS/Galileo observations in the un-differenced and between-satellite single-difference (BSSD) modes. These include the traditional un-differenced model, the decoupled clock model, the semi-decoupled clock model, and the between-satellite single-difference model. We take advantage of the IGS-MGEX network products to correct for the satellite differential code biases and the orbital and satellite clock errors. Natural Resources Canada’s GPSPace PPP software is modified to handle the various GPS/Galileo PPP models. A total of six data sets of GPS and Galileo observations at six IGS stations are processed to examine the performance of the various PPP models. It is shown that the traditional un-differenced GPS/Galileo PPP model, the GPS decoupled clock model, and the semi-decoupled clock GPS/Galileo PPP model improve the convergence time by about 25% in comparison with the un-differenced GPS-only model. In addition, the semi-decoupled GPS/Galileo PPP model improves the solution precision by about 25% compared to the traditional un-differenced GPS/Galileo PPP model. Moreover, the BSSD GPS/Galileo PPP model improves the solution convergence time by about 50%, in comparison with the un-differenced GPS PPP model, regardless of the type of BSSD combination used. As well, the BSSD model improves the precision of the estimated parameters by about 50% and 25% when the loose and the tight combinations are used, respectively, in comparison with the un-differenced GPS-only model. Comparable results are obtained through the tight combination when either a GPS or a Galileo satellite is selected as a reference. PMID:26102495

  4. PRECISION AGRICULTURE MASTERS PROGRAM - EDUCATING MISSOURI CROP PRODUCERS ABOUT THE BENEFITS OF PRECISION AGRICULTURE MANAGEMENT THROUGH ON-FARM RESEARCH

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The Precision Agriculture Masters (PAM) Program was initiated to enhance the transfer of technology related to precision agriculture to Missouri's crop producers. The PAM program consists of three parts: the precision agriculture knowledge network available through the Missouri Precision Agricultur...

  5. Mixed-Precision Spectral Deferred Correction: Preprint

    SciTech Connect

    Grout, Ray W. S.

    2015-09-02

    Convergence of spectral deferred correction (SDC), where low-order time integration methods are used to construct higher-order methods through iterative refinement, can be accelerated in terms of computational effort by using mixed-precision methods. Using ideas from multi-level SDC (in turn based on FAS multigrid ideas), some of the SDC correction sweeps can use function values computed in reduced precision without adversely impacting the accuracy of the final solution. This is particularly beneficial for the performance of combustion solvers such as S3D [6] which require double precision accuracy but are performance limited by the cost of data motion.

  6. The Future of Precision Medicine in Oncology.

    PubMed

    Millner, Lori M; Strotman, Lindsay N

    2016-09-01

    Precision medicine in oncology focuses on identifying which therapies are most effective for each patient based on genetic characterization of the cancer. Traditional chemotherapy is cytotoxic and destroys all cells that are rapidly dividing. The foundation of precision medicine is targeted therapies and selecting patients who will benefit most from these therapies. One of the newest aspects of precision medicine is liquid biopsy. A liquid biopsy includes analysis of circulating tumor cells, cell-free nucleic acid, or exosomes obtained from a peripheral blood draw. These can be studied individually or in combination and collected serially, providing real-time information as a patient's cancer changes. PMID:27514468

  7. Increased localization precision by interference fringe analysis.

    PubMed

    Ebeling, Carl G; Meiri, Amihai; Martineau, Jason; Zalevsky, Zeev; Gerton, Jordan M; Menon, Rajesh

    2015-06-21

    We report a novel optical single-emitter-localization methodology that uses the phase induced by path length differences in a Mach-Zehnder interferometer to improve localization precision. Using information theory, we demonstrate that the localization capability of a modified Fourier domain signal generated by photon interference enables a more precise localization compared to a standard Gaussian intensity distribution of the corresponding point-spread function. The calculations were verified by numerical simulations and an exemplary experiment, where the centers of metal nanoparticles were localized to a precision of 3 nm. PMID:25999093

  8. Courseware Review: Vernier Software: Precision Timer II.

    ERIC Educational Resources Information Center

    Park, John C.

    1988-01-01

    Reviews "Vernier Software: Precision Timer II" for high school through college mechanics. Introduces 14 different modes including pulse time, pendulum timer, bouncer timer, gate timer, collision timers, and stroke calibration. Provides two typical displays and ratings of the software. (YP)

  9. Nucleon measurements at the precision frontier

    SciTech Connect

    Carlson, Carl E.

    2013-11-07

    We comment on nucleon measurements at the precision frontier. As examples of what can be learned, we concentrate on three topics, which are parity violating scattering experiments, the proton radius puzzle, and the symbiosis between nuclear and atomic physics.

  10. Precision Engineering within the National Ignition Campaign

    SciTech Connect

    Taylor, J S; Carlisle, K; Klingmann, J L; Geraghty, P; Saito, T T; Montesanti, R C

    2010-02-17

    In this very brief talk, we'll discuss how precision engineering impacts 4 key areas of NIF: (1) Diamond turning of KDP crystals; (2) Mitigation of laser damage on optics; (3) Alignment of lasers, targets, diagnostics; (4) Target fabrication.

  11. Precision controllability of the F-15 airplane

    NASA Technical Reports Server (NTRS)

    Sisk, T. R.; Matheny, N. W.

    1979-01-01

    A flying qualities evaluation conducted on a preproduction F-15 airplane permitted an assessment to be made of its precision controllability in the high subsonic and low transonic flight regime over the allowable angle of attack range. Precision controllability, or gunsight tracking, studies were conducted in windup turn maneuvers with the gunsight in the caged pipper mode and depressed 70 mils. This evaluation showed the F-15 airplane to experience severe buffet and mild-to-moderate wing rock at the higher angles of attack. It showed the F-15 airplane radial tracking precision to vary from approximately 6 to 20 mils over the load factor range tested. Tracking in the presence of wing rock essentially doubled the radial tracking error generated at the lower angles of attack. The stability augmentation system affected the tracking precision of the F-15 airplane more than it did that of previous aircraft studied.

  12. 21 CFR 872.3165 - Precision attachment.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...) MEDICAL DEVICES DENTAL DEVICES Prosthetic Devices § 872.3165 Precision attachment. (a) Identification. A... or greater gold and metals of the platinum group intended for use in prosthetic dentistry...

  13. 21 CFR 872.3165 - Precision attachment.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...) MEDICAL DEVICES DENTAL DEVICES Prosthetic Devices § 872.3165 Precision attachment. (a) Identification. A... or greater gold and metals of the platinum group intended for use in prosthetic dentistry...

  14. 21 CFR 872.3165 - Precision attachment.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...) MEDICAL DEVICES DENTAL DEVICES Prosthetic Devices § 872.3165 Precision attachment. (a) Identification. A... or greater gold and metals of the platinum group intended for use in prosthetic dentistry...

  15. Toward precision medicine in neurological diseases

    PubMed Central

    Tan, Lin; Jiang, Teng

    2016-01-01

    Technological development has paved the way for accelerated genomic discovery and is bringing precision medicine into view. The goal of precision medicine is to deliver optimally targeted and timed interventions tailored to an individual’s molecular drivers of disease. Neurological diseases are promisingly suited models for precision medicine because of the rapidly expanding genetic knowledge base, phenotypic classification, the development of biomarkers and the potential modifying treatments. Moving forward, it is crucial that through these integrated research platforms to provide analysis both for accurate personal genome analysis and gene and drug discovery. Here we describe our vision of how precision medicine can bring greater clarity to the clinical and biological complexity of neurological diseases. PMID:27127757

  16. Isoflurane ameliorates acute lung injury by preserving epithelial tight junction integrity

    PubMed Central

    Englert, Joshua A.; Macias, Alvaro A.; Amador-Munoz, Diana; Vera, Miguel Pinilla; Isabelle, Colleen; Guan, Jiazhen; Magaoay, Brady; Velandia, Margarita Suarez; Coronata, Anna; Lee, Awapuhi; Fredenburgh, Laura E.; Culley, Deborah J.; Crosby, Gregory; Baron, Rebecca M.

    2015-01-01

    Background Isoflurane may be protective in pre-clinical models of lung injury but its use in patients with lung injury remains controversial and the mechanism of its protective effects remains unclear. We hypothesized that this protection is mediated at the level of alveolar tight junctions and investigated the possibility in a two-hit model of lung injury that mirrors human acute respiratory distress syndrome. Methods Wild-type mice were treated with isoflurane one hour after exposure to nebulized endotoxin (n=8) or saline control (n=9) then allowed to recover for 24 hrs prior to mechanical ventilation (MV, tidal volume 15 mL/kg, 2 hrs) producing ventilator-induced lung injury. Mouse lung epithelial cells were similarly treated with isoflurane one hour after exposure to lipopolysaccharide. Cells were cyclically stretched the following day to mirror the MV protocol used in vivo. Results Mice treated with isoflurane following exposure to inhaled endotoxin and prior to MV exhibited significantly less physiologic lung dysfunction. These effects appeared to be mediated by decreased vascular leak, but not altered inflammatory indices. Mouse lung epithelial cells treated with lipopolysaccharide and cyclic stretch and lungs harvested from mice following treatment with lipopolysaccharide and MV had decreased levels of a key tight junction protein (i.e. zona occludens 1) that was rescued by isoflurane treatment. Conclusions Isoflurane rescued lung injury induced by a two-hit model of endotoxin exposure followed by MV by maintaining the integrity of the alveolar-capillary barrier possibly by modulating the expression of a key tight junction protein. PMID:26068207

  17. Universal tight binding model for chemical reactions in solution and at surfaces. I. Organic molecules

    SciTech Connect

    Sheppard, T. J.; Lozovoi, A. Y.; Kohanoff, J. J.; Pashov, D. L.; Paxton, A. T.

    2014-07-28

    As is now well established, a first order expansion of the Hohenberg–Kohn total energy density functional about a trial input density, namely, the Harris–Foulkes functional, can be used to rationalize a non self consistent tight binding model. If the expansion is taken to second order then the energy and electron density matrix need to be calculated self consistently and from this functional one can derive a charge self consistent tight binding theory. In this paper we have used this to describe a polarizable ion tight binding model which has the benefit of treating charge transfer in point multipoles. This admits a ready description of ionic polarizability and crystal field splitting. It is necessary in constructing such a model to find a number of parameters that mimic their more exact counterparts in the density functional theory. We describe in detail how this is done using a combination of intuition, exact analytical fitting, and a genetic optimization algorithm. Having obtained model parameters we show that this constitutes a transferable scheme that can be applied rather universally to small and medium sized organic molecules. We have shown that the model gives a good account of static structural and dynamic vibrational properties of a library of molecules, and finally we demonstrate the model's capability by showing a real time simulation of an enolization reaction in aqueous solution. In two subsequent papers, we show that the model is a great deal more general in that it will describe solvents and solid substrates and that therefore we have created a self consistent quantum mechanical scheme that may be applied to simulations in heterogeneous catalysis.

  18. Applications of fluorescence microscopy to study of pores in tight rocks

    SciTech Connect

    Soeder, D.J.

    1987-05-01

    Observation of pore structures in thin section using the traditional method of impregnation with blue-dyed epoxy becomes difficult when the pores are smaller than about 1 micrometer and/or linear in shape. These types of pores are common in many gas-bearing tight formations, including coal seams, black shales, and lenticular sandstones. Incident-light fluorescence microscopy can be utilized for observation of small, narrow pore structures in tight rocks. Adaptation of this common medical technique to petrography is accomplished by staining the epoxy with fluorescent Rhodamine-B dye instead of the usual blue material, impregnating under vacuum, and preparing a polished thin section in the normal manner. The thin section is observed using an incident-light microscope equipped for fluorescence, which usually involves only a simple lamp and filter change on an existing, universal-type microscope. Under excitation of green light at a wavelength of 540 nm, the Rhodamine fluoresces a brilliant reddish orange, clearly showing impregnated pore space. A dichromatic interference filter in the light path allows only the reddish orange light to pass through, blacking out the mineral grains such that only the pore structure is visible. The incident-light configuration of the microscope has the advantage of inducing brighter fluorescence at higher magnifications due to the more intense concentration of the exciter beam through higher-power objectives. This technique also permits observation of impregnated pore space narrower than the wave-lengths of visible light. Epoxy fluorescing in pores this small behaves like a point source and makes the pore visible. Fluorescence microscopy has much promise for studying pore structures in tight sedimentary rocks and can also be applied to crystalline rocks and other materials containing narrow, linear, or small pores.

  19. Probiotics modify tight-junction proteins in an animal model of nonalcoholic fatty liver disease

    PubMed Central

    Briskey, David; Heritage, Mandy; Jaskowski, Lesley-Anne; Peake, Jonathan; Gobe, Glenda; Subramaniam, V. Nathan; Crawford, Darrell; Campbell, Catherine; Vitetta, Luis

    2016-01-01

    Background: We have investigated the effects of a multispecies probiotic preparation containing a combination of probiotic bacterial genera that included Bifidobacteria, Lactobacilli and a Streptococcus in a mouse model of high-fat diet or obesity-induced liver steatosis. Methods: Three groups of C57B1/6J mice were fed either a standard chow or a high-fat diet for 20 weeks, while a third group was fed a high-fat diet for 10 weeks and then concomitantly administered probiotics for a further 10 weeks. Serum, liver and large bowel samples were collected for analysis. Results: The expression of the tight-junction proteins ZO-1 and ZO-2 was reduced (p < 0.05) in high-fat diet-fed mice compared to chow-fed mice. Probiotic supplementation helped to maintain tight ZO-1 and ZO-2 expression compared with the high-fat diet group (p < 0.05), but did not restore ZO-1 or ZO-2 expression compared with chow-fed mice. Mice fed a high-fat diet ± probiotics had significant steatosis development compared with chow-fed mice (p < 0.05); steatosis was less severe in the probiotics group compared with the high-fat diet group. Hepatic triglyceride concentration was higher in mice fed a high-fat diet ± probiotics compared with the chow group (p < 0.05), and was lower in the probiotics group compared with the high-fat diet group (p < 0.05). Compared with chow-fed mice, serum glucose, cholesterol concentration and the activity of alanine transaminase were higher (p < 0.05), whereas serum triglyceride concentration was lower (p < 0.05) in mice fed a high-fat diet ± probiotics. Conclusions: Supplementation with a multispecies probiotic formulation helped to maintain tight-junction proteins ZO-1 and ZO-2, and reduced hepatic triglyceride concentration compared with a high-fat diet alone. PMID:27366215

  20. Universal tight binding model for chemical reactions in solution and at surfaces. I. Organic molecules

    NASA Astrophysics Data System (ADS)

    Sheppard, T. J.; Lozovoi, A. Y.; Pashov, D. L.; Kohanoff, J. J.; Paxton, A. T.

    2014-07-01

    As is now well established, a first order expansion of the Hohenberg-Kohn total energy density functional about a trial input density, namely, the Harris-Foulkes functional, can be used to rationalize a non self consistent tight binding model. If the expansion is taken to second order then the energy and electron density matrix need to be calculated self consistently and from this functional one can derive a charge self consistent tight binding theory. In this paper we have used this to describe a polarizable ion tight binding model which has the benefit of treating charge transfer in point multipoles. This admits a ready description of ionic polarizability and crystal field splitting. It is necessary in constructing such a model to find a number of parameters that mimic their more exact counterparts in the density functional theory. We describe in detail how this is done using a combination of intuition, exact analytical fitting, and a genetic optimization algorithm. Having obtained model parameters we show that this constitutes a transferable scheme that can be applied rather universally to small and medium sized organic molecules. We have shown that the model gives a good account of static structural and dynamic vibrational properties of a library of molecules, and finally we demonstrate the model's capability by showing a real time simulation of an enolization reaction in aqueous solution. In two subsequent papers, we show that the model is a great deal more general in that it will describe solvents and solid substrates and that therefore we have created a self consistent quantum mechanical scheme that may be applied to simulations in heterogeneous catalysis.