Science.gov

Sample records for preservation acceptance model

  1. A Distributive Model of Treatment Acceptability

    ERIC Educational Resources Information Center

    Carter, Stacy L.

    2008-01-01

    A model of treatment acceptability is proposed that distributes overall treatment acceptability into three separate categories of influence. The categories are comprised of societal influences, consultant influences, and influences associated with consumers of treatments. Each of these categories are defined and their inter-relationships within…

  2. Integrated Model for E-Learning Acceptance

    NASA Astrophysics Data System (ADS)

    Ramadiani; Rodziah, A.; Hasan, S. M.; Rusli, A.; Noraini, C.

    2016-01-01

    E-learning is not going to work if the system is not used in accordance with user needs. User Interface is very important to encourage using the application. Many theories had discuss about user interface usability evaluation and technology acceptance separately, actually why we do not make it correlation between interface usability evaluation and user acceptance to enhance e-learning process. Therefore, the evaluation model for e-learning interface acceptance is considered important to investigate. The aim of this study is to propose the integrated e-learning user interface acceptance evaluation model. This model was combined some theories of e-learning interface measurement such as, user learning style, usability evaluation, and the user benefit. We formulated in constructive questionnaires which were shared at 125 English Language School (ELS) students. This research statistics used Structural Equation Model using LISREL v8.80 and MANOVA analysis.

  3. Model of aircraft passenger acceptance

    NASA Technical Reports Server (NTRS)

    Jacobson, I. D.

    1978-01-01

    A technique developed to evaluate the passenger response to a transportation system environment is described. Reactions to motion, noise, temperature, seating, ventilation, sudden jolts and descents are modeled. Statistics are presented for the age, sex, occupation, and income distributions of the candidates analyzed. Values are noted for the relative importance of system variables such as time savings, on-time arrival, convenience, comfort, safety, the ability to read and write, and onboard services.

  4. Preserving Structure in Model-Free Tracking.

    PubMed

    Zhang, Lu; van der Maaten, Laurens J P

    2014-04-01

    Model-free trackers can track arbitrary objects based on a single (bounding-box) annotation of the object. Whilst the performance of model-free trackers has recently improved significantly, simultaneously tracking multiple objects with similar appearance remains very hard. In this paper, we propose a new multi-object model-free tracker (using a tracking-by-detection framework) that resolves this problem by incorporating spatial constraints between the objects. The spatial constraints are learned along with the object detectors using an online structured SVM algorithm. The experimental evaluation of our structure-preserving object tracker (SPOT) reveals substantial performance improvements in multi-object tracking. We also show that SPOT can improve the performance of single-object trackers by simultaneously tracking different parts of the object. Moreover, we show that SPOT can be used to adapt generic, model-based object detectors during tracking to tailor them towards a specific instance of that object. PMID:26353198

  5. Preservation of protein clefts in comparative models

    PubMed Central

    Piedra, David; Lois, Sergi; de la Cruz, Xavier

    2008-01-01

    Background Comparative, or homology, modelling of protein structures is the most widely used prediction method when the target protein has homologues of known structure. Given that the quality of a model may vary greatly, several studies have been devoted to identifying the factors that influence modelling results. These studies usually consider the protein as a whole, and only a few provide a separate discussion of the behaviour of biologically relevant features of the protein. Given the value of the latter for many applications, here we extended previous work by analysing the preservation of native protein clefts in homology models. We chose to examine clefts because of their role in protein function/structure, as they are usually the locus of protein-protein interactions, host the enzymes' active site, or, in the case of protein domains, can also be the locus of domain-domain interactions that lead to the structure of the whole protein. Results We studied how the largest cleft of a protein varies in comparative models. To this end, we analysed a set of 53507 homology models that cover the whole sequence identity range, with a special emphasis on medium and low similarities. More precisely we examined how cleft quality – measured using six complementary parameters related to both global shape and local atomic environment, depends on the sequence identity between target and template proteins. In addition to this general analysis, we also explored the impact of a number of factors on cleft quality, and found that the relationship between quality and sequence identity varies depending on cleft rank amongst the set of protein clefts (when ordered according to size), and number of aligned residues. Conclusion We have examined cleft quality in homology models at a range of seq.id. levels. Our results provide a detailed view of how quality is affected by distinct parameters and thus may help the user of comparative modelling to determine the final quality and

  6. A Diffuse Interface Model with Immiscibility Preservation

    PubMed Central

    Tiwari, Arpit; Freund, Jonathan B.; Pantano, Carlos

    2013-01-01

    A new, simple, and computationally efficient interface capturing scheme based on a diffuse interface approach is presented for simulation of compressible multiphase flows. Multi-fluid interfaces are represented using field variables (interface functions) with associated transport equations that are augmented, with respect to an established formulation, to enforce a selected interface thickness. The resulting interface region can be set just thick enough to be resolved by the underlying mesh and numerical method, yet thin enough to provide an efficient model for dynamics of well-resolved scales. A key advance in the present method is that the interface regularization is asymptotically compatible with the thermodynamic mixture laws of the mixture model upon which it is constructed. It incorporates first-order pressure and velocity non-equilibrium effects while preserving interface conditions for equilibrium flows, even within the thin diffused mixture region. We first quantify the improved convergence of this formulation in some widely used one-dimensional configurations, then show that it enables fundamentally better simulations of bubble dynamics. Demonstrations include both a spherical bubble collapse, which is shown to maintain excellent symmetry despite the Cartesian mesh, and a jetting bubble collapse adjacent a wall. Comparisons show that without the new formulation the jet is suppressed by numerical diffusion leading to qualitatively incorrect results. PMID:24058207

  7. Measuring Technology Acceptance Level of Turkish Pre-Service English Teachers by Using Technology Acceptance Model

    ERIC Educational Resources Information Center

    Kirmizi, Özkan

    2014-01-01

    The aim of this study is to investigate technology acceptance of prospective English teachers by using Technology Acceptance Model (TAM) in Turkish context. The study is based on Structural Equation Model (SEM). The participants of the study from English Language Teaching Departments of Hacettepe, Gazi and Baskent Universities. The participants…

  8. Causal mediation analyses with rank preserving models.

    PubMed

    Have, Thomas R Ten; Joffe, Marshall M; Lynch, Kevin G; Brown, Gregory K; Maisto, Stephen A; Beck, Aaron T

    2007-09-01

    We present a linear rank preserving model (RPM) approach for analyzing mediation of a randomized baseline intervention's effect on a univariate follow-up outcome. Unlike standard mediation analyses, our approach does not assume that the mediating factor is also randomly assigned to individuals in addition to the randomized baseline intervention (i.e., sequential ignorability), but does make several structural interaction assumptions that currently are untestable. The G-estimation procedure for the proposed RPM represents an extension of the work on direct effects of randomized intervention effects for survival outcomes by Robins and Greenland (1994, Journal of the American Statistical Association 89, 737-749) and on intervention non-adherence by Ten Have et al. (2004, Journal of the American Statistical Association 99, 8-16). Simulations show good estimation and confidence interval performance by the proposed RPM approach under unmeasured confounding relative to the standard mediation approach, but poor performance under departures from the structural interaction assumptions. The trade-off between these assumptions is evaluated in the context of two suicide/depression intervention studies. PMID:17825022

  9. Stochastic Human Exposure and Dose Simulation Model for Wood Preservatives

    EPA Science Inventory

    SHEDS-Wood (Stochastic Human Exposure and Dose Simulation Model for Wood Preservatives) is a physically-based stochastic model that was developed to quantify exposure and dose of children to wood preservatives on treated playsets and residential decks. Probabilistic inputs are co...

  10. New ideas and their acceptance. As it has related to preservation of chordae tendinea and certain other discoveries.

    PubMed

    Lillehei, C W

    1995-10-01

    The significant benefits of preserving chordal-papillary muscle integrity in mitral valve replacement took some two decades to become widely accepted. Familiarity with history clearly tells us that this paradox between our dedication to "new ideas" on the one hand, and opposition to their acceptance on the other has existed for hundreds of years. Most "new ideas" have been surrounded by controversy and opposition before wide acceptance. Selected examples from history are cited beginning with Roger Bacon in the 13th century, and continuing with Galileo, Semmelweiss, Lister, and Forssmann. The author cites two notable examples from his personal experiences. They occurred during the development of open heart surgery, and another during the development of the rigid bileaflet cardiac prosthesis, now known as the St. Jude cardiac prosthesis. Some of the basic reasons for this inevitable opposition are: an innate skepticism over anything "new." Simplicity is often resented, as well as any need to change patterns of behavior/habits. Determination, persistence, stubbornness are the most important components for successful research. In addition, the successful innovator must learn to expect opposition and not be deterred by it, but rather must learn to take sustenance from it, and "learn to thrive upon opposition." In conclusion, these observations and suggestions are summarized in a satire on "The Seven Ages in the Evolution of an Idea--with particular reference to the critic." PMID:8563985

  11. 49 CFR 41.120 - Acceptable model codes.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 1 2014-10-01 2014-10-01 false Acceptable model codes. 41.120 Section 41.120 Transportation Office of the Secretary of Transportation SEISMIC SAFETY § 41.120 Acceptable model codes. (a) This... of this part. (b)(1) The following are model codes which have been found to provide a level...

  12. 49 CFR 41.120 - Acceptable model codes.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Acceptable model codes. 41.120 Section 41.120 Transportation Office of the Secretary of Transportation SEISMIC SAFETY § 41.120 Acceptable model codes. (a) This... of this part. (b)(1) The following are model codes which have been found to provide a level...

  13. Technological Diffusion within Educational Institutions: Applying the Technology Acceptance Model.

    ERIC Educational Resources Information Center

    Wolski, Stacy; Jackson, Sally

    Expectancy models of behavior such as the Theory of Reasoned Action (TRA) and the Technology Acceptance Model (TAM) offer guidelines that aid efforts to facilitate use of new technology. These models remind us that both acceptance of and resistance to technology use are grounded in beliefs and norms regarding the technology. Although TAM is widely…

  14. Evaluation of the Acceptance of Audience Response System by Corporations Using the Technology Acceptance Model

    NASA Astrophysics Data System (ADS)

    Chu, Hsing-Hui; Lu, Ta-Jung; Wann, Jong-Wen

    The purpose of this research is to explore enterprises' acceptance of Audience Response System (ARS) using Technology Acceptance Model (TAM). The findings show that (1) IT characteristics and facilitating conditions could be external variables of TAM. (2) The degree of E-business has positive significant correlation with behavioral intention of employees. (3) TAM is a good model to predict and explain IT acceptance. (4) Demographic variables, industry and firm characteristics have no significant correlation with ARS acceptance. The results provide useful information to managers and ARS providers that (1) ARS providers should focus more on creating different usages to enhance interactivity and employees' using intention. (2) Managers should pay attention to build sound internal facilitating conditions for introducing IT. (3) According to the degree of E-business, managers should set up strategic stages of introducing IT. (4) Providers should increase product promotion and also leverage academic and government to promote ARS.

  15. Solar Corona Simulation Model With Positivity-preserving Property

    NASA Astrophysics Data System (ADS)

    Feng, X. S.

    2015-12-01

    Positivity-preserving is one of crucial problems in solar corona simulation. In such numerical simulation of low plasma β region, keeping density and pressure is a first of all matter to obtain physical sound solution. In the present paper, we utilize the maximum-principle-preserving flux limiting technique to develop a class of second order positivity-preserving Godunov finite volume HLL methods for the solar wind plasma MHD equations. Based on the underlying first order building block of positivity preserving Lax-Friedrichs, our schemes, under the constrained transport (CT) and generalized Lagrange multiplier (GLM) framework, can achieve high order accuracy, a discrete divergence-free condition and positivity of the numerical solution simultaneously without extra CFL constraints. Numerical results in four Carrington rotation during the declining, rising, minimum and maximum solar activity phases are provided to demonstrate the performance of modeling small plasma beta with positivity-preserving property of the proposed method.

  16. Cultured lung epithelium: A cellular model for lung preservation.

    PubMed

    Lee, C Y; Matsumoto-Pon, J; Widdicombe, J H

    1997-11-01

    Cellular models have helped with the development of conditions needed for hypothermic preservation of kidney, liver, and heart. Recently, highly differentiated cultured lung epithelial cell lines grown with basolateral side feeding technique have become available that can mimic airspace, epithelium, and interstitium of lung parenchyma. Cultured lung epithelium coupled with Ussing's short-circuit current technique was used as a cellular model system for lung preservation. A parametric study was conducted to correlate the effects of luminal fluid composition (University of Wisconsin (UW) solution and phosphate-buffered saline) and storage gas (air vs nitrogen) at 4 degrees C for 24 h on postischemic electrogenic properties (transepithelial ion transport and resistance). The results showed that cells were better preserved with the UW solution on both sides as measured by their transepithelial resistance, an indicator of tight junction integrity (Rte approximately 65% of control values approximately 135 Omega cm2). In addition, they responded better to mediators that stimulate chloride secretion than cells preserved with other conditions. Cells preserved with no additional fluid on the apical side had substantially lowered Rte (<20%) than those preserved with an additional thin layer of fluid ( approximately 35-65%). This cellular model system is a realistic representation of lung epithelium and can provide an accurate assessment of preservation quality through the measurements of tight junction integrity and active ion transport. PMID:9367609

  17. User Acceptance of Long-Term Evolution (LTE) Services: An Application of Extended Technology Acceptance Model

    ERIC Educational Resources Information Center

    Park, Eunil; Kim, Ki Joon

    2013-01-01

    Purpose: The aim of this paper is to propose an integrated path model in order to explore user acceptance of long-term evolution (LTE) services by examining potential causal relationships between key psychological factors and user intention to use the services. Design/methodology/approach: Online survey data collected from 1,344 users are analysed…

  18. Examining Engineering & Technology Students' Acceptance of Network Virtualization Technology Using the Technology Acceptance Model

    ERIC Educational Resources Information Center

    Yousif, Wael K.

    2010-01-01

    This causal and correlational study was designed to extend the Technology Acceptance Model (TAM) and to test its applicability to Valencia Community College (VCC) Engineering and Technology students as the target user group when investigating the factors influencing their decision to adopt and to utilize VMware as the target technology. In…

  19. User Acceptance of YouTube for Procedural Learning: An Extension of the Technology Acceptance Model

    ERIC Educational Resources Information Center

    Lee, Doo Young; Lehto, Mark R.

    2013-01-01

    The present study was framed using the Technology Acceptance Model (TAM) to identify determinants affecting behavioral intention to use YouTube. Most importantly, this research emphasizes the motives for using YouTube, which is notable given its extrinsic task goal of being used for procedural learning tasks. Our conceptual framework included two…

  20. Preserving Flow Variability in Watershed Model Calibrations

    EPA Science Inventory

    Background/Question/Methods Although watershed modeling flow calibration techniques often emphasize a specific flow mode, ecological conditions that depend on flow-ecology relationships often emphasize a range of flow conditions. We used informal likelihood methods to investig...

  1. Model Preservation Program for a Small University Library.

    ERIC Educational Resources Information Center

    Robbins, Louise S.

    This report proposes a preservation program assuming a model of a university library serving 5,000 or fewer students and 350 or fewer faculty members. The model program is not for a comprehensive university or research institution, and the library's collection is one developed and used as a curriculum-support collection. The goal of the…

  2. USEPA SHEDS MODEL: METHODOLOGY FOR EXPOSURE ASSESSMENT FOR WOOD PRESERVATIVES

    EPA Science Inventory

    A physically-based, Monte Carlo probabilistic model (SHEDS-Wood: Stochastic Human Exposure and Dose Simulation model for wood preservatives) has been applied to assess the exposure and dose of children to arsenic (As) and chromium (Cr) from contact with chromated copper arsenat...

  3. Preserving Pelicans with Models That Make Sense

    ERIC Educational Resources Information Center

    Moore, Tamara J.; Doerr, Helen M.; Glancy, Aran W.; Ntow, Forster D.

    2015-01-01

    Getting students to think deeply about mathematical concepts is not an easy job, which is why we often use problem-solving tasks to engage students in higher-level mathematical thinking. Mathematical modeling, one of the mathematical practices found in the Common Core State Standards for Mathematics (CCSSM), is a type of problem solving that can…

  4. Asymptotic-preserving Boltzmann model equations for binary gas mixture

    NASA Astrophysics Data System (ADS)

    Liu, Sha; Liang, Yihua

    2016-02-01

    An improved system of Boltzmann model equations is developed for binary gas mixture. This system of model equations has a complete asymptotic preserving property that can strictly recover the Navier-Stokes equations in the continuum limit with the correct constitutive relations and the correct viscosity, thermal conduction, diffusion, and thermal diffusion coefficients. In this equation system, the self- and cross-collision terms in Boltzmann equations are replaced by single relaxation terms. In monocomponent case, this system of equations can be reduced to the commonly used Shakhov equation. The conservation property and the H theorem which are important for model equations are also satisfied by this system of model equations.

  5. Asymptotic-preserving Boltzmann model equations for binary gas mixture.

    PubMed

    Liu, Sha; Liang, Yihua

    2016-02-01

    An improved system of Boltzmann model equations is developed for binary gas mixture. This system of model equations has a complete asymptotic preserving property that can strictly recover the Navier-Stokes equations in the continuum limit with the correct constitutive relations and the correct viscosity, thermal conduction, diffusion, and thermal diffusion coefficients. In this equation system, the self- and cross-collision terms in Boltzmann equations are replaced by single relaxation terms. In monocomponent case, this system of equations can be reduced to the commonly used Shakhov equation. The conservation property and the H theorem which are important for model equations are also satisfied by this system of model equations. PMID:26986408

  6. Predicting User Acceptance of Collaborative Technologies: An Extension of the Technology Acceptance Model for E-Learning

    ERIC Educational Resources Information Center

    Cheung, Ronnie; Vogel, Doug

    2013-01-01

    Collaborative technologies support group work in project-based environments. In this study, we enhance the technology acceptance model to explain the factors that influence the acceptance of Google Applications for collaborative learning. The enhanced model was empirically evaluated using survey data collected from 136 students enrolled in a…

  7. Acceptance of health information technology in health professionals: an application of the revised technology acceptance model.

    PubMed

    Ketikidis, Panayiotis; Dimitrovski, Tomislav; Lazuras, Lambros; Bath, Peter A

    2012-06-01

    The response of health professionals to the use of health information technology (HIT) is an important research topic that can partly explain the success or failure of any HIT application. The present study applied a modified version of the revised technology acceptance model (TAM) to assess the relevant beliefs and acceptance of HIT systems in a sample of health professionals (n = 133). Structured anonymous questionnaires were used and a cross-sectional design was employed. The main outcome measure was the intention to use HIT systems. ANOVA was employed to examine differences in TAM-related variables between nurses and medical doctors, and no significant differences were found. Multiple linear regression analysis was used to assess the predictors of HIT usage intentions. The findings showed that perceived ease of use, but not usefulness, relevance and subjective norms directly predicted HIT usage intentions. The present findings suggest that a modification of the original TAM approach is needed to better understand health professionals' support and endorsement of HIT. Perceived ease of use, relevance of HIT to the medical and nursing professions, as well as social influences, should be tapped by information campaigns aiming to enhance support for HIT in healthcare settings. PMID:22733680

  8. Modeling the stratigraphy and preservation potential of meandering stream deposits

    NASA Astrophysics Data System (ADS)

    Tucker, G. E.; Clevis, Q.; Lock, G.; Lancaster, S.; Desitter, A.

    2003-12-01

    Both natural and human-induced modes of river and floodplain behavior have the potential to obscure, expose, or even destroy portions of the archaeological record. In valley systems with actively meandering channels much material can be lost to lateral bank erosion. Conversely, floodplain aggradation can bury and therefore obscure sites. In this study we aim to quantify the preservation potential of fluvial units containing archaeological sites as a function of the natural process of meandering, climate change and increased land-use during the Holocene. We used the CHILD simulation model of landscape evolution to explore alternative scenarios in which these three factors are both varied independently and combined. Boundary and initial conditions for the model scenarios are based on the Holocene evolution of the archaeologically-rich Upper Thames Valley, which is known to have witnessed variations in flood frequency, land-clearance, episodic alluviation and river entrenchment. The CHILD model is set up to combine four components that simulate the development of valley and floodplain system: hillslope and channel erosion, lateral stream meandering, overbank deposition, and the accumulation of a 3D stratigraphy. The landscape is represented by an adaptable triangular mesh of nodes, especially suited for simulating the gradual shifting of meander bends. The new stratigraphic layering routine recently added to the model in improves the resolution of the stratigraphic record accumulated by the model. Simulation results reveal systematic controls on preservation potential, and suggest potential sources of bias in the archaeological record.

  9. Modeling of the charge acceptance of lead-acid batteries

    NASA Astrophysics Data System (ADS)

    Thele, M.; Schiffer, J.; Karden, E.; Surewaard, E.; Sauer, D. U.

    This paper presents a model for flooded and VRLA batteries that is parameterized by impedance spectroscopy and includes the overcharging effects to allow charge-acceptance simulations (e.g. for regenerative-braking drive-cycle profiles). The full dynamic behavior and the short-term charge/discharge history is taken into account. This is achieved by a detailed modeling of the sulfate crystal growth and modeling of the internal gas recombination cycle. The model is applicable in the full realistic temperature and current range of automotive applications. For model validation, several load profiles (covering the dynamics and the current range appearing in electrically assisted or hybrid cars) are examined and the charge-acceptance limiting effects are elaborately discussed. The validation measurements have been performed for different types of lead-acid batteries (flooded and VRLA). The model is therefore an important tool for the development of automotive power nets, but it also allows to analyze different charging strategies and energy gains which can be achieved during regenerative-braking.

  10. Variations in immunohistochemical preservation of proteins in a mummification model

    PubMed Central

    Metcalfe, Ryan; Freemont, Tony

    2012-01-01

    Immunohistochemistry is an important tool in the investigation of ancient mummified remains because of its ability not only to detect proteins but also to isolate their location to specific tissues and thereby improve confidence that the results are genuine. A mouse model of Egyptian mummification has been used to demonstrate that the survival of proteins, judged by the retention of immunohistochemical staining, varies markedly. Some survive the process well, whereas others become barely detectable despite the morphology of the tissue being excellently preserved. The results obtained show that protein preservation is multi-factorial, with tissue type and degradation, and the properties of the protein itself all having significant effects. Proteins forming large, multi-subunit complexes such as collagen IV appear to be more resistant to degradation than those that do not, such as S-100. Although modern modelling studies cannot replicate the full extent of degradative processes and taphonomic changes experienced by real mummies, the results obtained can be useful for guiding research that requires ancient tissues. PMID:22050406

  11. Variations in immunohistochemical preservation of proteins in a mummification model.

    PubMed

    Metcalfe, Ryan; Freemont, Tony

    2012-01-01

    Immunohistochemistry is an important tool in the investigation of ancient mummified remains because of its ability not only to detect proteins but also to isolate their location to specific tissues and thereby improve confidence that the results are genuine. A mouse model of Egyptian mummification has been used to demonstrate that the survival of proteins, judged by the retention of immunohistochemical staining, varies markedly. Some survive the process well, whereas others become barely detectable despite the morphology of the tissue being excellently preserved. The results obtained show that protein preservation is multi-factorial, with tissue type and degradation, and the properties of the protein itself all having significant effects. Proteins forming large, multi-subunit complexes such as collagen IV appear to be more resistant to degradation than those that do not, such as S-100. Although modern modelling studies cannot replicate the full extent of degradative processes and taphonomic changes experienced by real mummies, the results obtained can be useful for guiding research that requires ancient tissues. PMID:22050406

  12. Factors Influencing the Acceptance of Web-Based Training in Malaysia: Applying the Technology Acceptance Model

    ERIC Educational Resources Information Center

    Hashim, Junaidah

    2008-01-01

    Companies in Malaysia are beginning to use web-based training to reduce the cost of training and to provide employees with greater access to instruction. However, some people are uncomfortable with technology and prefer person-to-person methods of training. This study examines the acceptance of web-based training among a convenience sample of 261…

  13. A Mathematical Model of Evolutionary Pressures Regulating Self-Preservation and Self-Destruction.

    ERIC Educational Resources Information Center

    de Catanzaro, Denys

    1986-01-01

    Focuses upon self-preservation, as it pervades the general patterns of behavior of all organisms, over the totality of biological evolution. Asserts that self-preservation has definable limitations that can be modeled mathematically. Suggests natural selection does not invariably favor tendencies toward self-preservation. Argues that reproduction…

  14. Swarm intelligence algorithm for interconnect model order reduction with sub-block structure preserving

    NASA Astrophysics Data System (ADS)

    Wang, Xinsheng; Wang, Chenxu; Yu, Mingyan

    2016-07-01

    In this paper, we propose a generalised sub-block structure preservation interconnect model order reduction (MOR) technique based on the swarm intelligence method, that is, particle swarm optimisation (PSO). The swarm intelligence-based structure preservation MOR can be used for a standard model as a criterion for different structure preservation interconnect MOR methods. In the proposed technique, the PSO method is used for predicting the unknown elements of structure-preserving reduced-order modelling of interconnect circuits. The prediction is based on minimising the difference of transform function between the original full-order and desired reduced-order systems maintaining the full-order structure in the reduced-order model. The proposed swarm-intelligence-based structure-preserving MOR method is compared with published work on structure preservation MOR SPRIM techniques. Simulation and synthesis results verify the accuracy and validity of the new structure-preserving MOR technique.

  15. The History of UTAUT Model and Its Impact on ICT Acceptance and Usage by Academicians

    ERIC Educational Resources Information Center

    Oye, N. D.; Iahad, N. A.; Rahim, N. Ab.

    2014-01-01

    This paper started with the review of the history of technology acceptance model from TRA to UTAUT. The expected contribution is to bring to lime light the current development stage of the technology acceptance model. Based on this, the paper examined the impact of UTAUT model on ICT acceptance and usage in HEIs. The UTAUT model theory was…

  16. Influence of Gender and Computer Teaching Efficacy on Computer Acceptance among Malaysian Student Teachers: An Extended Technology Acceptance Model

    ERIC Educational Resources Information Center

    Wong, Kung-Teck; Teo, Timothy; Russo, Sharon

    2012-01-01

    The purpose of this study is to validate the technology acceptance model (TAM) in an educational context and explore the role of gender and computer teaching efficacy as external variables. From the literature, it appeared that only limited studies had developed models to explain statistically the chain of influence of computer teaching efficacy…

  17. Modeling Computer Usage Intentions of Tertiary Students in a Developing Country through the Technology Acceptance Model

    ERIC Educational Resources Information Center

    Afari-Kumah, Eben; Achampong, Akwasi Kyere

    2010-01-01

    This study aims to examine the computer usage intentions of Ghanaian Tertiary Students. The Technology Acceptance Model was adopted as the theoretical framework to ascertain whether it could help explain behavioral intentions of individuals to accept and use technology. Factor analysis was used to assess the construct validity of the initial…

  18. Angler survey contributes to socially acceptable modification of harvest regulations to preserve cutthroat trout fishery in Snake River, Wyoming, USA

    NASA Astrophysics Data System (ADS)

    Hubert, Wayne A.; Gipson, Robert D.

    1996-09-01

    This is a case study that describes a survey of anglers that was used to assist in modifying fishing regulations for indigenous trout in the Snake River, Wyoming. A mail survey of anglers who purchased 1991 Wyoming fishing licenses in the two counties adjacent to the Snake River was conducted during fall 1992. Differences in angler preferences were noted between anglers who purchased licenses in two adjacent counties with different socioeconomic structures, as well as between residents and nonresidents in each county. Anglers who purchased licenses in Teton County, where there is extensive tourism and immigration by relatively wealthy residents, tended to be more specialized and less harvest oriented. Anglers in Lincoln County, which is largely agricultural and has substantially less tourism and immigration of residents, tended to fish in many different ways and indicated more desire to harvest fish. Anglers from the two counties segregated themselves; those from Teton County primarily used the upstream portion of the study reach, and those from Lincoln County primarily used a short downstream portion of the reach. Modification of fishing regulations to reduce harvest of spawning-size cutthroat trout in the Snake River probably was acceptable to most anglers due to spatial segregation and their attitudes toward harvest.

  19. Modeling eBook acceptance: A study on mathematics teachers

    NASA Astrophysics Data System (ADS)

    Jalal, Azlin Abd; Ayub, Ahmad Fauzi Mohd; Tarmizi, Rohani Ahmad

    2014-12-01

    The integration and effectiveness of eBook utilization in Mathematics teaching and learning greatly relied upon the teachers, hence the need to understand their perceptions and beliefs. The eBook, an individual laptop completed with digitized textbook sofwares, were provided for each students in line with the concept of 1 student:1 laptop. This study focuses on predicting a model on the acceptance of the eBook among Mathematics teachers. Data was collected from 304 mathematics teachers in selected schools using a survey questionnaire. The selection were based on the proportionate stratified sampling. Structural Equation Modeling (SEM) were employed where the model was tested and evaluated and was found to have a good fit. The variance explained for the teachers' attitude towards eBook is approximately 69.1% where perceived usefulness appeared to be a stronger determinant compared to perceived ease of use. This study concluded that the attitude of mathematics teachers towards eBook depends largely on the perception of how useful the eBook is on improving their teaching performance, implying that teachers should be kept updated with the latest mathematical application and sofwares to use with the eBook to ensure positive attitude towards using it in class.

  20. A method of preserving and testing the acceptability of gac fruit oil, a good source of beta-carotene and essential fatty acids.

    PubMed

    Vuong, L T; King, J C

    2003-06-01

    Gac fruit (Momordica cochinchinensis Spreng) is indigenous to Vietnam and other countries in Southeast Asia. Its seed pulp contains high concentrations of carotenoids, especially the provitamin A, beta-carotene. In northern Vietnam, gac fruits are seasonal and are mainly used in making a rice dish called xoi gac. The purpose of this study was to develop a method to collect and preserve gac fruit oil, to evaluate the nutritional composition of the oil, and to assess the acceptability of the gac oil by typical Vietnamese homemakers. One hundred women participated in training to learn how to prepare the fruits and operate the oil press. The women also participated in a survey of gac fruit use and their habitual use of animal fat and vegetable oil. Among all the participants in the training and surveys, 35 women actually produced oil from gac fruits grown in the village, using manual oil presses and locally available materials. The total carotene concentration in gac fruit oil was 5,700 micrograms/ml. The concentration of beta-carotene was 2,710 micrograms/ml. Sixty-nine percent of total fat was unsaturated, and 35% of that was polyunsaturated. The average daily consumption of gac fruit oil was estimated at 2 ml per person. The daily beta-carotene intake (from gac fruit oil) averaged approximately 5 mg per person. It was found that gac oil can be produced locally by village women using manual presses and locally available materials. The oil is a rich source of beta-carotene, vitamin E, and essential fatty acids. Although the beta-carotene concentration declines with time without a preservative or proper storage, it was still high after three months. The oil was readily accepted by the women and their children, and consumption of the oil increased the intake of beta-carotene and reduced the intake of lard. PMID:12891827

  1. Use of shape-preserving interpolation methods in surface modeling

    NASA Technical Reports Server (NTRS)

    Ftitsch, F. N.

    1984-01-01

    In many large-scale scientific computations, it is necessary to use surface models based on information provided at only a finite number of points (rather than determined everywhere via an analytic formula). As an example, an equation of state (EOS) table may provide values of pressure as a function of temperature and density for a particular material. These values, while known quite accurately, are typically known only on a rectangular (but generally quite nonuniform) mesh in (T,d)-space. Thus interpolation methods are necessary to completely determine the EOS surface. The most primitive EOS interpolation scheme is bilinear interpolation. This has the advantages of depending only on local information, so that changes in data remote from a mesh element have no effect on the surface over the element, and of preserving shape information, such as monotonicity. Most scientific calculations, however, require greater smoothness. Standard higher-order interpolation schemes, such as Coons patches or bicubic splines, while providing the requisite smoothness, tend to produce surfaces that are not physically reasonable. This means that the interpolant may have bumps or wiggles that are not supported by the data. The mathematical quantification of ideas such as physically reasonable and visually pleasing is examined.

  2. Beyond poiseuille: preservation fluid flow in an experimental model.

    PubMed

    Singh, Saurabh; Randle, Lucy V; Callaghan, Paul T; Watson, Christopher J E; Callaghan, Chris J

    2013-01-01

    Poiseuille's equation describes the relationship between fluid viscosity, pressure, tubing diameter, and flow, yet it is not known if cold organ perfusion systems follow this equation. We investigated these relationships in an ex vivo model and aimed to offer some rationale for equipment selection. Increasing the cannula size from 14 to 20 Fr increased flow rate by a mean (SD) of 13 (12)%. Marshall's hyperosmolar citrate was three times less viscous than UW solution, but flows were only 45% faster. Doubling the bag pressure led to a mean (SD) flow rate increase of only 19 (13)%, not twice the rate. When external pressure devices were used, 100 mmHg of continuous pressure increased flow by a mean (SD) of 43 (17)% when compared to the same pressure applied initially only. Poiseuille's equation was not followed; this is most likely due to "slipping" of preservation fluid within the plastic tubing. Cannula size made little difference over the ranges examined; flows are primarily determined by bag pressure and fluid viscosity. External infusor devices require continuous pressurisation to deliver high flow. Future studies examining the impact of perfusion variables on graft outcomes should include detailed equipment descriptions. PMID:24062943

  3. Beyond Poiseuille: Preservation Fluid Flow in an Experimental Model

    PubMed Central

    Singh, Saurabh; Randle, Lucy V.; Callaghan, Paul T.; Watson, Christopher J. E.; Callaghan, Chris J.

    2013-01-01

    Poiseuille's equation describes the relationship between fluid viscosity, pressure, tubing diameter, and flow, yet it is not known if cold organ perfusion systems follow this equation. We investigated these relationships in an ex vivo model and aimed to offer some rationale for equipment selection. Increasing the cannula size from 14 to 20 Fr increased flow rate by a mean (SD) of 13 (12)%. Marshall's hyperosmolar citrate was three times less viscous than UW solution, but flows were only 45% faster. Doubling the bag pressure led to a mean (SD) flow rate increase of only 19 (13)%, not twice the rate. When external pressure devices were used, 100 mmHg of continuous pressure increased flow by a mean (SD) of 43 (17)% when compared to the same pressure applied initially only. Poiseuille's equation was not followed; this is most likely due to “slipping” of preservation fluid within the plastic tubing. Cannula size made little difference over the ranges examined; flows are primarily determined by bag pressure and fluid viscosity. External infusor devices require continuous pressurisation to deliver high flow. Future studies examining the impact of perfusion variables on graft outcomes should include detailed equipment descriptions. PMID:24062943

  4. User Acceptance of Information Technology: Theories and Models.

    ERIC Educational Resources Information Center

    Dillon, Andrew; Morris, Michael G.

    1996-01-01

    Reviews literature in user acceptance and resistance to information technology design and implementation. Examines innovation diffusion, technology design and implementation, human-computer interaction, and information systems. Concentrates on the determinants of user acceptance and resistance and emphasizes how researchers and developers can…

  5. Do I Have to Learn Something New? Mental Models and the Acceptance of Replacement Technologies

    ERIC Educational Resources Information Center

    Zhang, Wei; Xu, Peng

    2011-01-01

    Few studies in technology acceptance have explicitly addressed the acceptance of replacement technologies, technologies that replace legacy ones that have been in use. This article explores this issue through the theoretical lens of mental models. We contend that accepting replacement technologies entails both mental model maintenance and mental…

  6. The Adult Roles Models Program: Feasibility, Acceptability, and Initial Outcomes

    PubMed Central

    Silver, Ellen Johnson; Dean, Randa; Perez, Amanda; Rivera, Angelic

    2014-01-01

    We present the feasibility and acceptability of a parent sexuality education program led by peer educators in community settings. We also report the results of an outcome evaluation with 71 parents who were randomized to the intervention or a control group, and surveyed one month prior to and six months after the 4-week intervention. The program was highly feasible and acceptable to participants, and the curriculum was implemented with a high level of fidelity and facilitator quality. Pilot data show promising outcomes for increasing parental knowledge, communication, and monitoring of their adolescent children. PMID:24883051

  7. Hybrid E-Learning Acceptance Model: Learner Perceptions

    ERIC Educational Resources Information Center

    Ahmed, Hassan M. Selim

    2010-01-01

    E-learning tools and technologies have been used to supplement conventional courses in higher education institutions creating a "hybrid" e-learning module that aims to enhance the learning experiences of students. Few studies have addressed the acceptance of hybrid e-learning by learners and the factors affecting the learners'…

  8. Privacy-Preserving Evaluation of Generalization Error and Its Application to Model and Attribute Selection

    NASA Astrophysics Data System (ADS)

    Sakuma, Jun; Wright, Rebecca N.

    Privacy-preserving classification is the task of learning or training a classifier on the union of privately distributed datasets without sharing the datasets. The emphasis of existing studies in privacy-preserving classification has primarily been put on the design of privacy-preserving versions of particular data mining algorithms, However, in classification problems, preprocessing and postprocessing— such as model selection or attribute selection—play a prominent role in achieving higher classification accuracy. In this paper, we show generalization error of classifiers in privacy-preserving classification can be securely evaluated without sharing prediction results. Our main technical contribution is a new generalized Hamming distance protocol that is universally applicable to preprocessing and postprocessing of various privacy-preserving classification problems, such as model selection in support vector machine and attribute selection in naive Bayes classification.

  9. Acceptance and Commitment Therapy as a Unified Model of Behavior Change

    ERIC Educational Resources Information Center

    Hayes, Steven C.; Pistorello, Jacqueline; Levin, Michael E.

    2012-01-01

    The present article summarizes the assumptions, model, techniques, evidence, and diversity/social justice commitments of Acceptance and Commitment Therapy (ACT). ACT focused on six processes (acceptance, defusion, self, now, values, and action) that bear on a single overall target (psychological flexibility). The ACT model of behavior change has…

  10. Expectancies Underlying the Acceptability of Handicaps: The Pervasiveness of the Medical Model

    ERIC Educational Resources Information Center

    Abroms, Kippy; Kodera, Thomas L.

    1978-01-01

    Two groups of undergraduate students with diverse backgrounds ranked the acceptability of 15 handicapping conditions of which some were medical disorders and others were sociopsychological or functional impairments. Students adhered to the medical model, basing their judgments of acceptability on the amenability of a given handicap to medical…

  11. Modelling acceptance of sunlight in high and low photovoltaic concentration

    SciTech Connect

    Leutz, Ralf

    2014-09-26

    A simple model incorporating linear radiation characteristics, along with the optical trains and geometrical concentration ratios of solar concentrators is presented with performance examples for optical trains of HCPV, LCPV and benchmark flat-plate PV.

  12. Thermodynamic investigation of the interaction between cyclodextrins and preservatives - Application and verification in a mathematical model to determine the needed preservative surplus in aqueous cyclodextrin formulations.

    PubMed

    Holm, René; Olesen, Niels Erik; Alexandersen, Signe Dalgaard; Dahlgaard, Birgitte N; Westh, Peter; Mu, Huiling

    2016-05-25

    Preservatives are inactivated when added to conserve aqueous cyclodextrin (CD) formulations due to complex formation between CDs and the preservative. To maintain the desired conservation effect the preservative needs to be added in apparent surplus to account for this inactivation. The purpose of the present work was to establish a mathematical model, which defines this surplus based upon knowledge of stability constants and the minimal concentration of preservation to inhibit bacterial growth. The stability constants of benzoic acid, methyl- and propyl-paraben with different frequently used βCDs were determined by isothermal titration calorimetry. Based upon this knowledge mathematical models were constructed to account for the equilibrium systems and to calculate the required concentration of the preservations, which was evaluated experimentally based upon the USP/Ph. Eur./JP monograph. The mathematical calculations were able to predict the needed concentration of preservation in the presence of CDs; it clearly demonstrated the usefulness of including all underlying chemical equilibria in a mathematical model, such that the formulation design can be based on quantitative arguments. PMID:26391874

  13. Family support and acceptance, gay male identity formation, and psychological adjustment: a path model.

    PubMed

    Elizur, Y; Ziv, M

    2001-01-01

    While heterosexist family undermining has been demonstrated to be a developmental risk factor in the life of persons with same-gender orientation, the issue of protective family factors is both controversial and relatively neglected. In this study of Israeli gay males (N = 114), we focused on the interrelations of family support, family acceptance and family knowledge of gay orientation, and gay male identity formation, and their effects on mental health and self-esteem. A path model was proposed based on the hypotheses that family support, family acceptance, family knowledge, and gay identity formation have an impact on psychological adjustment, and that family support has an effect on gay identity formation that is mediated by family acceptance. The assessment of gay identity formation was based on an established stage model that was streamlined for cross-cultural practice by defining three basic processes of same-gender identity formation: self-definition, self-acceptance, and disclosure (Elizur & Mintzer, 2001). The testing of our conceptual path model demonstrated an excellent fit with the data. An alternative model that hypothesized effects of gay male identity on family acceptance and family knowledge did not fit the data. Interpreting these results, we propose that the main effect of family support/acceptance on gay identity is related to the process of disclosure, and that both general family support and family acceptance of same-gender orientation play a significant role in the psychological adjustment of gay men. PMID:11444052

  14. Preserving Lagrangian Structure in Nonlinear Model Reduction with Application to Structural Dynamics

    DOE PAGESBeta

    Carlberg, Kevin; Tuminaro, Ray; Boggs, Paul

    2015-03-11

    Our work proposes a model-reduction methodology that preserves Lagrangian structure and achieves computational efficiency in the presence of high-order nonlinearities and arbitrary parameter dependence. As such, the resulting reduced-order model retains key properties such as energy conservation and symplectic time-evolution maps. We focus on parameterized simple mechanical systems subjected to Rayleigh damping and external forces, and consider an application to nonlinear structural dynamics. To preserve structure, the method first approximates the system's “Lagrangian ingredients''---the Riemannian metric, the potential-energy function, the dissipation function, and the external force---and subsequently derives reduced-order equations of motion by applying the (forced) Euler--Lagrange equation with thesemore » quantities. Moreover, from the algebraic perspective, key contributions include two efficient techniques for approximating parameterized reduced matrices while preserving symmetry and positive definiteness: matrix gappy proper orthogonal decomposition and reduced-basis sparsification. Our results for a parameterized truss-structure problem demonstrate the practical importance of preserving Lagrangian structure and illustrate the proposed method's merits: it reduces computation time while maintaining high accuracy and stability, in contrast to existing nonlinear model-reduction techniques that do not preserve structure.« less

  15. Preserving Lagrangian Structure in Nonlinear Model Reduction with Application to Structural Dynamics

    SciTech Connect

    Carlberg, Kevin; Tuminaro, Ray; Boggs, Paul

    2015-03-11

    Our work proposes a model-reduction methodology that preserves Lagrangian structure and achieves computational efficiency in the presence of high-order nonlinearities and arbitrary parameter dependence. As such, the resulting reduced-order model retains key properties such as energy conservation and symplectic time-evolution maps. We focus on parameterized simple mechanical systems subjected to Rayleigh damping and external forces, and consider an application to nonlinear structural dynamics. To preserve structure, the method first approximates the system's “Lagrangian ingredients''---the Riemannian metric, the potential-energy function, the dissipation function, and the external force---and subsequently derives reduced-order equations of motion by applying the (forced) Euler--Lagrange equation with these quantities. Moreover, from the algebraic perspective, key contributions include two efficient techniques for approximating parameterized reduced matrices while preserving symmetry and positive definiteness: matrix gappy proper orthogonal decomposition and reduced-basis sparsification. Our results for a parameterized truss-structure problem demonstrate the practical importance of preserving Lagrangian structure and illustrate the proposed method's merits: it reduces computation time while maintaining high accuracy and stability, in contrast to existing nonlinear model-reduction techniques that do not preserve structure.

  16. Adolescents' unconditional acceptance by parents and teachers and educational outcomes: A structural model of gender differences.

    PubMed

    Makri-Botsari, Evi

    2015-08-01

    The purpose of this study was to detect gender specific patterns in the network of relations between unconditionality of parental and teacher acceptance in the form of unconditional positive regard and a range of educational outcomes, as indexed by academic self-perception, academic intrinsic motivation, and academic achievement. To test the role of gender as a moderator, a multi-group analysis was employed within the framework of structural equation modelling with increasing restrictions placed on the structural paths across genders. The results on a sample of 427 adolescents in grades 7-9 showed that conditionality of acceptance undermined level of perceived acceptance for both social agents. Moreover, unconditionality of teacher acceptance exerted stronger influences on students' educational outcomes than unconditionality of parental acceptance, with effect sizes being larger for girls than for boys. PMID:26057875

  17. A proposed model of factors influencing hydrogen fuel cell vehicle acceptance

    NASA Astrophysics Data System (ADS)

    Imanina, N. H. Noor; Kwe Lu, Tan; Fadhilah, A. R.

    2016-03-01

    Issues such as environmental problem and energy insecurity keep worsening as a result of energy use from household to huge industries including automotive industry. Recently, a new type of zero emission vehicle, hydrogen fuel cell vehicle (HFCV) has received attention. Although there are argues on the feasibility of hydrogen as the future fuel, there is another important issue, which is the acceptance of HFCV. The study of technology acceptance in the early stage is a vital key for a successful introduction and penetration of a technology. This paper proposes a model of factors influencing green vehicle acceptance, specifically HFCV. This model is built base on two technology acceptance theories and other empirical studies of vehicle acceptance. It aims to provide a base for finding the key factors influencing new sustainable energy fuelled vehicle, HFCV acceptance which is achieved by explaining intention to accept HFCV. Intention is influenced by attitude, subjective norm and perceived behavioural control from Theory of Planned Behaviour and personal norm from Norm Activation Theory. In the framework, attitude is influenced by perceptions of benefits and risks, and social trust. Perceived behavioural control is influenced by government interventions. Personal norm is influenced by outcome efficacy and problem awareness.

  18. A Multivariate Model for the Study of Parental Acceptance-Rejection and Child Abuse.

    ERIC Educational Resources Information Center

    Rohner, Ronald P.; Rohner, Evelyn C.

    This paper proposes a multivariate strategy for the study of parental acceptance-rejection and child abuse and describes a research study on parental rejection and child abuse which illustrates the advantages of using a multivariate, (rather than a simple-model) approach. The multivariate model is a combination of three simple models used to study…

  19. Utilizing the health belief model to assess vaccine acceptance of patients on hemodialysis.

    PubMed

    Adams, Angela; Hall, Mellisa; Fulghum, Janis

    2014-01-01

    Vaccine rates in patients on hemodialysis are substantially lower than the Healthy People 2020 targets. The purpose of this study is to utilize the perceptions and cues for action constructs of the Health Belief Model (HBM) to assess the attitudes of patients receiving outpatient hemodialysis regarding acceptance of the seasonal influenza, pneumococcal, and hepatitis B virus vaccines. Vaccine acceptance is defined as receiving the vaccine. Study findings suggest age, perceived susceptibility, and perceived severity increase the odds of getting some vaccines. Findings have implications for the development of patient education materials, interdisciplinary team assessments, and plan of care strategies to increase vaccine acceptance. PMID:25244894

  20. THE TECHNOLOGY ACCEPTANCE MODEL: ITS PAST AND ITS FUTURE IN HEALTH CARE

    PubMed Central

    HOLDEN, RICHARD J.; KARSH, BEN-TZION

    2009-01-01

    Increasing interest in end users’ reactions to health information technology (IT) has elevated the importance of theories that predict and explain health IT acceptance and use. This paper reviews the application of one such theory, the Technology Acceptance Model (TAM), to health care. We reviewed 16 data sets analyzed in over 20 studies of clinicians using health IT for patient care. Studies differed greatly in samples and settings, health ITs studied, research models, relationships tested, and construct operationalization. Certain TAM relationships were consistently found to be significant, whereas others were inconsistent. Several key relationships were infrequently assessed. Findings show that TAM predicts a substantial portion of the use or acceptance of health IT, but that the theory may benefit from several additions and modifications. Aside from improved study quality, standardization, and theoretically motivated additions to the model, an important future direction for TAM is to adapt the model specifically to the health care context, using beliefs elicitation methods. PMID:19615467

  1. Dynamic access control model for privacy preserving personalized healthcare in cloud environment.

    PubMed

    Son, Jiseong; Kim, Jeong-Dong; Na, Hong-Seok; Baik, Doo-Kwon

    2015-01-01

    When sharing and storing healthcare data in a cloud environment, access control is a central issue for preserving data privacy as a patient's personal health data may be accessed without permission from many stakeholders. Specifically, dynamic authorization for the access of data is required because personal health data is stored in cloud storage via wearable devices. Therefore, we propose a dynamic access control model for preserving the privacy of personal healthcare data in a cloud environment. The proposed model considers context information for dynamic access. According to the proposed model, access control can be dynamically determined by changing the context information; this means that even for a subject with the same role in the cloud, access permission is defined differently depending on the context information and access condition. Furthermore, we experiment the ability of the proposed model to provide correct responses by representing a dynamic access decision with real-life personalized healthcare system scenarios. PMID:26409546

  2. Modeling the acceptance of clinical information systems among hospital medical staff: an extended TAM model.

    PubMed

    Melas, Christos D; Zampetakis, Leonidas A; Dimopoulou, Anastasia; Moustakis, Vassilis

    2011-08-01

    Recent empirical research has utilized the Technology Acceptance Model (TAM) to advance the understanding of doctors' and nurses' technology acceptance in the workplace. However, the majority of the reported studies are either qualitative in nature or use small convenience samples of medical staff. Additionally, in very few studies moderators are either used or assessed despite their importance in TAM based research. The present study focuses on the application of TAM in order to explain the intention to use clinical information systems, in a random sample of 604 medical staff (534 physicians) working in 14 hospitals in Greece. We introduce physicians' specialty as a moderator in TAM and test medical staff's information and communication technology (ICT) knowledge and ICT feature demands, as external variables. The results show that TAM predicts a substantial proportion of the intention to use clinical information systems. Findings make a contribution to the literature by replicating, explaining and advancing the TAM, whereas theory is benefited by the addition of external variables and medical specialty as a moderator. Recommendations for further research are discussed. PMID:21292029

  3. Extending the Technology Acceptance Model to Explore the Intention to Use Second Life for Enhancing Healthcare Education

    ERIC Educational Resources Information Center

    Chow, Meyrick; Herold, David Kurt; Choo, Tat-Ming; Chan, Kitty

    2012-01-01

    Learners need to have good reasons to engage and accept e-learning. They need to understand that unless they do, the outcomes will be less favourable. The technology acceptance model (TAM) is the most widely recognized model addressing why users accept or reject technology. This study describes the development and evaluation of a virtual…

  4. Testing a developmental cascade model of emotional and social competence and early peer acceptance

    PubMed Central

    Blandon, Alysia Y.; Calkins, Susan D.; Grimm, Kevin J.; Keane, Susan P.; O’Brien, Marion

    2011-01-01

    A developmental cascade model of early emotional and social competence predicting later peer acceptance was examined in a community sample of 440 children across the ages of 2 to 7. Children’s externalizing behavior, emotion regulation, social skills within the classroom and peer acceptance were examined utilizing a multitrait-multimethod approach. A series of longitudinal cross-lag models that controlled for shared rater variance were fit using structural equation modeling. Results indicated there was considerable stability in children’s externalizing behavior problems and classroom social skills over time. Contrary to expectations, there were no reciprocal influences between externalizing behavior problems and emotion regulation, though higher levels of emotion regulation were associated with decreases in subsequent levels of externalizing behaviors. Finally, children’s early social skills also predicted later peer acceptance. Results underscore the complex associations among emotional and social functioning across early childhood. PMID:20883578

  5. Stochastic optimization model for order acceptance with multiple demand classes and uncertain demand/supply

    NASA Astrophysics Data System (ADS)

    Yang, Wen; Fung, Richard Y. K.

    2014-06-01

    This article considers an order acceptance problem in a make-to-stock manufacturing system with multiple demand classes in a finite time horizon. Demands in different periods are random variables and are independent of one another, and replenishments of inventory deviate from the scheduled quantities. The objective of this work is to maximize the expected net profit over the planning horizon by deciding the fraction of the demand that is going to be fulfilled. This article presents a stochastic order acceptance optimization model and analyses the existence of the optimal promising policies. An example of a discrete problem is used to illustrate the policies by applying the dynamic programming method. In order to solve the continuous problems, a heuristic algorithm based on stochastic approximation (HASA) is developed. Finally, the computational results of a case example illustrate the effectiveness and efficiency of the HASA approach, and make the application of the proposed model readily acceptable.

  6. 24 CFR 200.926c - Model code provisions for use in partially accepted code jurisdictions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Model code provisions for use in partially accepted code jurisdictions. 200.926c Section 200.926c Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR...

  7. Perceived Convenience in an Extended Technology Acceptance Model: Mobile Technology and English Learning for College Students

    ERIC Educational Resources Information Center

    Chang, Chi-Cheng; Yan, Chi-Fang; Tseng, Ju-Shih

    2012-01-01

    Since convenience is one of the features for mobile learning, does it affect attitude and intention of using mobile technology? The technology acceptance model (TAM), proposed by David (1989), was extended with perceived convenience in the present study. With regard to English language mobile learning, the variables in the extended TAM and its…

  8. Extended TAM Model: Impacts of Convenience on Acceptance and Use of Moodle

    ERIC Educational Resources Information Center

    Hsu, Hsiao-hui; Chang, Yu-ying

    2013-01-01

    The increasing online access to courses, programs, and information has shifted the control and responsibility of learning process from instructors to learners. Learners' perceptions of and attitudes toward e-learning constitute a critical factor to the success of such system. The purpose of this study is to take TAM (technology acceptance model)…

  9. Examining the Factors That Contribute to Successful Database Application Implementation Using the Technology Acceptance Model

    ERIC Educational Resources Information Center

    Nworji, Alexander O.

    2013-01-01

    Most organizations spend millions of dollars due to the impact of improperly implemented database application systems as evidenced by poor data quality problems. The purpose of this quantitative study was to use, and extend, the technology acceptance model (TAM) to assess the impact of information quality and technical quality factors on database…

  10. 24 CFR 200.926c - Model code provisions for use in partially accepted code jurisdictions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Model code provisions for use in partially accepted code jurisdictions. 200.926c Section 200.926c Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT...

  11. An Investigation of the Integrated Model of User Technology Acceptance: Internet User Samples in Four Countries

    ERIC Educational Resources Information Center

    Fusilier, Marcelline; Durlabhji, Subhash; Cucchi, Alain

    2008-01-01

    National background of users may influence the process of technology acceptance. The present study explored this issue with the new, integrated technology use model proposed by Sun and Zhang (2006). Data were collected from samples of college students in India, Mauritius, Reunion Island, and United States. Questionnaire methodology and…

  12. 24 CFR 200.926c - Model code provisions for use in partially accepted code jurisdictions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Model code provisions for use in partially accepted code jurisdictions. 200.926c Section 200.926c Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT...

  13. Understanding Student Teachers' Behavioural Intention to Use Technology: Technology Acceptance Model (TAM) Validation and Testing

    ERIC Educational Resources Information Center

    Wong, Kung-Teck; Osman, Rosma bt; Goh, Pauline Swee Choo; Rahmat, Mohd Khairezan

    2013-01-01

    This study sets out to validate and test the Technology Acceptance Model (TAM) in the context of Malaysian student teachers' integration of their technology in teaching and learning. To establish factorial validity, data collected from 302 respondents were tested against the TAM using confirmatory factor analysis (CFA), and structural equation…

  14. Groundwater Fate and Transport Modeling for Texarkana Wood Preserving Company Superfund Site, Texarkana, Texas

    SciTech Connect

    Arnett, Ronald Chester

    1999-08-01

    Fate and transport model results are presented for the Texarkana Wood Preserving Company (TWPC)superfund site. The conceptual model assumes two sources of contamination, specifically, the areas around the old and new process areas. Recent data show the presence of non-aqueous phase liquids (NAPL) in the aquifer that are also sources of dissolved contamination in the aquifer. A flow model was constructed and calibrated against measured hydraulic heads at permanent monitoring wells. Good matches were obtained between model simulated heads and most measured heads. An unexplained exception occurs at monitoring well MW-13 down gradient of the site beyond the measured contaminant plume where the model predicts heads that are more than 2 ft. lower than reported field measurements. Adjusting hydraulic parameters in the model could not account for this anomaly and still preserve the head matches at other wells. There is likely a moderate deficiency in the conceptual model or perhaps a data error. Other information such as substantial amounts of infiltrating surface water in the area or a correction in surveyed elevation would improve the flow model. A particle tracking model calculated a travel time from the new process area to the Day’s Creek discharge location on the order of 40 years. Travel times from the old process area to Day’s Creek were calculated to be on the order of 80 years. While these calculations are subject to some uncertainty, travel times of decades are indicated.

  15. Design of preservation solutions for universal tissue preservation in vivo: demonstration of efficacy in preclinical models of profound hypothermic cardiac arrest.

    PubMed

    Taylor, M J; Rhee, P; Chen, Z; Alam, H B

    2005-01-01

    The design of new solutions for the universal preservation of tissues is a quest that would facilitate multiple-organ harvesting from organ donors since current preservation solutions do not provide optimum preservation for all organs. In contrast, a new approach to bloodless surgery using hypothermic blood substitution (HBS) to protect the whole body during profound hypothermic circulatory arrest (clinical suspended animation) has focused on the development of a hybrid solution design with the objective of providing universal tissue preservation. In this study, a porcine model of uncontrolled lethal hemorrhage was employed. A combination of two new solutions, maintenance and purge, was used in a cardiopulmonary bypass (CPB) technique to affect profound hypothermia and prolonged cardiac arrest (60 min), with resuscitation after surgical repair of the vascular deficit induced to affect exsanguination. After rewarming and recovery, pigs were monitored for 6 weeks for neurological deficits, cognitive function (learning new skills), and organ dysfunction. All the normothermic control animals died (n = 10), whereas 90% (9 of 10) in the HBS group survived (P < .05). Moreover, all of the survivors were neurologically intact, displayed normal learning and memory capability, and had no long-term organ dysfunction. Histology of brains after 6 weeks revealed no ischemic damage in marked contrast to control animals, which all showed diffuse ischemic damage. The demonstrated efficacy of these synthetic, acellular HBS solutions for protection of all the tissues in the body during clinical suspended animation justifies their consideration for multiple-organ harvesting from cadaveric and living donors. PMID:15808626

  16. Modeling of a Parabolic Trough Solar Field for Acceptance Testing: A Case Study

    SciTech Connect

    Wagner, M. J.; Mehos, M. S.; Kearney, D. W.; McMahan, A. C.

    2011-01-01

    As deployment of parabolic trough concentrating solar power (CSP) systems ramps up, the need for reliable and robust performance acceptance test guidelines for the solar field is also amplified. Project owners and/or EPC contractors often require extensive solar field performance testing as part of the plant commissioning process in order to ensure that actual solar field performance satisfies both technical specifications and performance guaranties between the involved parties. Performance test code work is currently underway at the National Renewable Energy Laboratory (NREL) in collaboration with the SolarPACES Task-I activity, and within the ASME PTC-52 committee. One important aspect of acceptance testing is the selection of a robust technology performance model. NREL1 has developed a detailed parabolic trough performance model within the SAM software tool. This model is capable of predicting solar field, sub-system, and component performance. It has further been modified for this work to support calculation at subhourly time steps. This paper presents the methodology and results of a case study comparing actual performance data for a parabolic trough solar field to the predicted results using the modified SAM trough model. Due to data limitations, the methodology is applied to a single collector loop, though it applies to larger subfields and entire solar fields. Special consideration is provided for the model formulation, improvements to the model formulation based on comparison with the collected data, and uncertainty associated with the measured data. Additionally, this paper identifies modeling considerations that are of particular importance in the solar field acceptance testing process and uses the model to provide preliminary recommendations regarding acceptable steady-state testing conditions at the single-loop level.

  17. Family caregivers' perspectives on dementia-related dressing difficulties at home: The preservation of self model.

    PubMed

    Mahoney, Diane F; LaRose, Sharon; Mahoney, Edward L

    2015-07-01

    Alzheimer's caregiving literature acknowledges dressing as a major daily stressor but research on this topic is negligible. A qualitative grounded theory approach was used to explore Alzheimer's family caregivers' perspectives about issues that arise when their family members lose the ability to dress independently. Three focus groups and seven individual interviews were conducted and audio recorded with 25 information rich caregivers. Constant comparative analyses and coding of the transcripts identified six major themes leading to a 'Preservation of Self Model: Care Recipient to Care Giver' that portrays the caregiving trajectory. Initially, caregivers tried to protect the self dignity of the family member by maintaining usual routines and absorbing blame for difficulties. Dressing 'battles' occurred and caregivers learned management through trial and error. Crossing adult-child-gender role boundaries escalated discomfort. When facing unrelenting demands, concern shifted to preservation of the caregivers' health and self. Results suggest that caregivers would benefit from more pro-active dressing counseling to shorten the trial and error periods, dressing aids more relevant to dementia and more knowledgeable helpers. The preservation model can facilitate understanding of the caregiving trajectory and guide intervention support. PMID:24339112

  18. Comparison of lung preservation solutions in human lungs using an ex vivo lung perfusion experimental model

    PubMed Central

    Medeiros, Israel L.; Pêgo-Fernandes, Paulo M.; Mariani, Alessandro W.; Fernandes, Flávio G.; Unterpertinger, Fernando V.; Canzian, Mauro; Jatene, Fabio B.

    2012-01-01

    OBJECTIVE: Experimental studies on lung preservation have always been performed using animal models. We present ex vivo lung perfusion as a new model for the study of lung preservation. Using human lungs instead of animal models may bring the results of experimental studies closer to what could be expected in clinical practice. METHOD: Brain-dead donors whose lungs had been declined by transplantation teams were used. The cases were randomized into two groups. In Group 1, Perfadex® was used for pulmonary preservation, and in Group 2, LPDnac, a solution manufactured in Brazil, was used. An ex vivo lung perfusion system was used, and the lungs were ventilated and perfused after 10 hours of cold ischemia. The extent of ischemic-reperfusion injury was measured using functional and histological parameters. RESULTS: After reperfusion, the mean oxygenation capacity was 405.3 mmHg in Group 1 and 406.0 mmHg in Group 2 (p = 0.98). The mean pulmonary vascular resistance values were 697.6 and 378.3 dyn·s·cm-5, respectively (p = 0.035). The mean pulmonary compliance was 46.8 cm H2O in Group 1 and 49.3 ml/cm H2O in Group 2 (p = 0.816). The mean wet/dry weight ratios were 2.06 and 2.02, respectively (p = 0.87). The mean Lung Injury Scores for the biopsy performed after reperfusion were 4.37 and 4.37 in Groups 1 and 2, respectively (p = 1.0), and the apoptotic cell counts were 118.75/mm2 and 137.50/mm2, respectively (p = 0.71). CONCLUSION: The locally produced preservation solution proved to be as good as Perfadex®. The clinical use of LPDnac may reduce costs in our centers. Therefore, it is important to develop new models to study lung preservation. PMID:23018310

  19. Understanding Intention to Use Electronic Information Resources: A Theoretical Extension of the Technology Acceptance Model (TAM)

    PubMed Central

    Tao, Donghua

    2008-01-01

    This study extended the Technology Acceptance Model (TAM) by examining the roles of two aspects of e-resource characteristics, namely, information quality and system quality, in predicting public health students’ intention to use e-resources for completing research paper assignments. Both focus groups and a questionnaire were used to collect data. Descriptive analysis, data screening, and Structural Equation Modeling (SEM) techniques were used for data analysis. The study found that perceived usefulness played a major role in determining students’ intention to use e-resources. Perceived usefulness and perceived ease of use fully mediated the impact that information quality and system quality had on behavior intention. The research model enriches the existing technology acceptance literature by extending TAM. Representing two aspects of e-resource characteristics provides greater explanatory information for diagnosing problems of system design, development, and implementation. PMID:18999300

  20. Social trust, risk perceptions and public acceptance of recycled water: testing a social-psychological model.

    PubMed

    Ross, Victoria L; Fielding, Kelly S; Louis, Winnifred R

    2014-05-01

    Faced with a severe drought, the residents of the regional city of Toowoomba, in South East Queensland, Australia were asked to consider a potable wastewater reuse scheme to supplement drinking water supplies. As public risk perceptions and trust have been shown to be key factors in acceptance of potable reuse projects, this research developed and tested a social-psychological model of trust, risk perceptions and acceptance. Participants (N = 380) were surveyed a few weeks before a referendum was held in which residents voted against the controversial scheme. Analysis using structural equation modelling showed that the more community members perceived that the water authority used fair procedures (e.g., consulting with the community and providing accurate information), the greater their sense of shared identity with the water authority. Shared social identity in turn influenced trust via increased source credibility, that is, perceptions that the water authority is competent and has the community's interest at heart. The findings also support past research showing that higher levels of trust in the water authority were associated with lower perceptions of risk, which in turn were associated with higher levels of acceptance, and vice versa. The findings have a practical application for improving public acceptance of potable recycled water schemes. PMID:24603028

  1. The acceptance of in silico models for REACH: Requirements, barriers, and perspectives

    PubMed Central

    2011-01-01

    In silico models have prompted considerable interest and debate because of their potential value in predicting the properties of chemical substances for regulatory purposes. The European REACH legislation promotes innovation and encourages the use of alternative methods, but in practice the use of in silico models is still very limited. There are many stakeholders influencing the regulatory trajectory of quantitative structure-activity relationships (QSAR) models, including regulators, industry, model developers and consultants. Here we outline some of the issues and challenges involved in the acceptance of these methods for regulatory purposes. PMID:21982269

  2. Adding Innovation Diffusion Theory to the Technology Acceptance Model: Supporting Employees' Intentions to Use E-Learning Systems

    ERIC Educational Resources Information Center

    Lee, Yi-Hsuan; Hsieh, Yi-Chuan; Hsu, Chia-Ning

    2011-01-01

    This study intends to investigate factors affecting business employees' behavioral intentions to use the e-learning system. Combining the innovation diffusion theory (IDT) with the technology acceptance model (TAM), the present study proposes an extended technology acceptance model. The proposed model was tested with data collected from 552…

  3. The Effects of a Modified Treatment Package with and without Feeder Modeling on One Child's Acceptance of Novel Foods

    ERIC Educational Resources Information Center

    Seiverling, Laura; Harclerode, Whitney; Williams, Keith

    2014-01-01

    The purpose of this study was to examine if sequential presentation with feeder modeling would lead to an increase in bites accepted of new foods compared to sequential presentation without feeder modeling in a typically developing 4-year-old boy with food selectivity. The participant's acceptance of novel foods increased both in the modeling and…

  4. Calcium glycerophosphate preserves transepithelial integrity in the Caco-2 model of intestinal transport

    PubMed Central

    Datta, Palika; Weis, Margaret T

    2015-01-01

    AIM: To assess the direct effects of ischemia on intestinal epithelial integrity. Furthermore, clinical efforts at mitigating the effect of hypoperfusion on gut permeability have focused on restoring gut vascular function. METHODS: We report that, in the Caco-2 cell model of transepithelial transport, calcium glycerophosphate (CGP), an inhibitor of intestinal alkaline phosphatase F3, has a significant effect to preserve transepithelial electrical resistance (TEER) and to attenuate increases in mannitol flux rates during hypoxia or cytokine stimulation. RESULTS: The effect was observable even at concentrations as low as 1 μmol/L. As celiac disease is also marked by a loss of gut epithelial integrity, the effect of CGP to attenuate the effect of the α-gliadin peptide 31-55 was also examined. In this instance, CGP exerted little effect of preservation of TEER, but significantly attenuated peptide induced increase in mannitol flux. CONCLUSION: It appears that CGP treatment might synergize with other therapies to preserve gut epithelial integrity. PMID:26290632

  5. An efficient and positivity-preserving layer method for modeling radiation belt diffusion processes

    NASA Astrophysics Data System (ADS)

    Tao, X.; Zhang, L.; Wang, C.; Li, X.; Albert, J. M.; Chan, A. A.

    2016-01-01

    An efficient and positivity-preserving layer method is introduced to solve the radiation belt diffusion equation and is applied to study the bounce resonance interaction between relativistic electrons and magnetosonic waves. The layer method with linear interpolation, denoted by LM-L (layer method-linear), requires the use of a large number of grid points to ensure accurate solutions. We introduce a monotonicity- and positivity-preserving cubic interpolation method to be used with the Milstein-Tretyakov layer method. The resulting method, called LM-MC (layer method-monotone cubic), can be used to solve the radiation belt diffusion equation with a much smaller number of grid points than LM-L while still being able to preserve the positivity of the solution. We suggest that LM-MC can be used to study long-term dynamics of radiation belts. We then develop a 2-D LM-MC code and use it to investigate the bounce resonance diffusion of radiation belt electrons by magnetosonic waves. Using a previously published magnetosonic wave model, we demonstrate that bounce resonance with magnetosonic waves is as important as gyroresonance; both can cause several orders of magnitude increase of MeV electron fluxes within 1 day. We conclude that bounce resonance with magnetosonic waves should be taken into consideration together with gyroresonance.

  6. Integrating Health Belief Model and Technology Acceptance Model: An Investigation of Health-Related Internet Use

    PubMed Central

    2015-01-01

    Background Today, people use the Internet to satisfy health-related information and communication needs. In Malaysia, Internet use for health management has become increasingly significant due to the increase in the incidence of chronic diseases, in particular among urban women and their desire to stay healthy. Past studies adopted the Technology Acceptance Model (TAM) and Health Belief Model (HBM) independently to explain Internet use for health-related purposes. Although both the TAM and HBM have their own merits, independently they lack the ability to explain the cognition and the related mechanism in which individuals use the Internet for health purposes. Objective This study aimed to examine the influence of perceived health risk and health consciousness on health-related Internet use based on the HBM. Drawing on the TAM, it also tested the mediating effects of perceived usefulness of the Internet for health information and attitude toward Internet use for health purposes for the relationship between health-related factors, namely perceived health risk and health consciousness on health-related Internet use. Methods Data obtained for the current study were collected using purposive sampling; the sample consisted of women in Malaysia who had Internet access. The partial least squares structural equation modeling method was used to test the research hypotheses developed. Results Perceived health risk (β=.135, t 1999=2.676) and health consciousness (β=.447, t 1999=9.168) had a positive influence on health-related Internet use. Moreover, perceived usefulness of the Internet and attitude toward Internet use for health-related purposes partially mediated the influence of health consciousness on health-related Internet use (β=.025, t 1999=3.234), whereas the effect of perceived health risk on health-related Internet use was fully mediated by perceived usefulness of the Internet and attitude (β=.029, t 1999=3.609). These results suggest the central role of

  7. Topology preservation and cooperative learning in identification of multiple model systems.

    PubMed

    Liu, Jianbo; Djurdjanovic, Dragan

    2008-12-01

    The self-organizing network (SON)-based multiple model system is a recently proposed method for identifying the dynamics of a general nonlinear system. It has been observed by researchers that cooperative learning among neighboring regions is sometimes important for the success of identification of a nonlinear system under the multiple model system framework. In this paper, we intend to formally evaluate the effects of cooperative learning and topology preservation in identification of multiple model system based on SON. The results of the mathematical analysis supports the heuristic that a good learning strategy for identifying the local model parameters of a SON-based multiple model system is to choose a neighborhood function whose effective region is initially wider and is reduced gradually during learning. An example of nonlinear function approximation is also provided at the end of this paper to demonstrate the results of the mathematical analysis. PMID:19054731

  8. Rank-preserving regression: a more robust rank regression model against outliers.

    PubMed

    Chen, Tian; Kowalski, Jeanne; Chen, Rui; Wu, Pan; Zhang, Hui; Feng, Changyong; Tu, Xin M

    2016-08-30

    Mean-based semi-parametric regression models such as the popular generalized estimating equations are widely used to improve robustness of inference over parametric models. Unfortunately, such models are quite sensitive to outlying observations. The Wilcoxon-score-based rank regression (RR) provides more robust estimates over generalized estimating equations against outliers. However, the RR and its extensions do not sufficiently address missing data arising in longitudinal studies. In this paper, we propose a new approach to address outliers under a different framework based on the functional response models. This functional-response-model-based alternative not only addresses limitations of the RR and its extensions for longitudinal data, but, with its rank-preserving property, even provides more robust estimates than these alternatives. The proposed approach is illustrated with both real and simulated data. Copyright © 2016 John Wiley & Sons, Ltd. PMID:26934999

  9. Surrogate modelling and optimization using shape-preserving response prediction: A review

    NASA Astrophysics Data System (ADS)

    Leifsson, Leifur; Koziel, Slawomir

    2016-03-01

    Computer simulation models are ubiquitous in modern engineering design. In many cases, they are the only way to evaluate a given design with sufficient fidelity. Unfortunately, an added computational expense is associated with higher fidelity models. Moreover, the systems being considered are often highly nonlinear and may feature a large number of designable parameters. Therefore, it may be impractical to solve the design problem with conventional optimization algorithms. A promising approach to alleviate these difficulties is surrogate-based optimization (SBO). Among proven SBO techniques, the methods utilizing surrogates constructed from corrected physics-based low-fidelity models are, in many cases, the most efficient. This article reviews a particular technique of this type, namely, shape-preserving response prediction (SPRP), which works on the level of the model responses to correct the underlying low-fidelity models. The formulation and limitations of SPRP are discussed. Applications to several engineering design problems are provided.

  10. An Empirical Assessment of a Technology Acceptance Model for Apps in Medical Education.

    PubMed

    Briz-Ponce, Laura; García-Peñalvo, Francisco José

    2015-11-01

    The evolution and the growth of mobile applications ("apps") in our society is a reality. This general trend is still upward and the app use has also penetrated the medical education community. However, there is a lot of unawareness of the students' and professionals' point of view about introducing "apps" within Medical School curriculum. The aim of this research is to design, implement and verify that the Technology Acceptance Model (TAM) can be employed to measure and explain the acceptance of mobile technology and "apps" within Medical Education. The methodology was based on a survey distributed to students and medical professionals from University of Salamanca. This model explains 46.7% of behavioral intention to use mobile devise or "apps" for learning and will help us to justify and understand the current situation of introducing "apps" into the Medical School curriculum. PMID:26411928

  11. A Privacy Preservation Model for Health-Related Social Networking Sites.

    PubMed

    Li, Jingquan

    2015-01-01

    The increasing use of social networking sites (SNS) in health care has resulted in a growing number of individuals posting personal health information online. These sites may disclose users' health information to many different individuals and organizations and mine it for a variety of commercial and research purposes, yet the revelation of personal health information to unauthorized individuals or entities brings a concomitant concern of greater risk for loss of privacy among users. Many users join multiple social networks for different purposes and enter personal and other specific information covering social, professional, and health domains into other websites. Integration of multiple online and real social networks makes the users vulnerable to unintentional and intentional security threats and misuse. This paper analyzes the privacy and security characteristics of leading health-related SNS. It presents a threat model and identifies the most important threats to users and SNS providers. Building on threat analysis and modeling, this paper presents a privacy preservation model that incorporates individual self-protection and privacy-by-design approaches and uses the model to develop principles and countermeasures to protect user privacy. This study paves the way for analysis and design of privacy-preserving mechanisms on health-related SNS. PMID:26155953

  12. A Privacy Preservation Model for Health-Related Social Networking Sites

    PubMed Central

    2015-01-01

    The increasing use of social networking sites (SNS) in health care has resulted in a growing number of individuals posting personal health information online. These sites may disclose users' health information to many different individuals and organizations and mine it for a variety of commercial and research purposes, yet the revelation of personal health information to unauthorized individuals or entities brings a concomitant concern of greater risk for loss of privacy among users. Many users join multiple social networks for different purposes and enter personal and other specific information covering social, professional, and health domains into other websites. Integration of multiple online and real social networks makes the users vulnerable to unintentional and intentional security threats and misuse. This paper analyzes the privacy and security characteristics of leading health-related SNS. It presents a threat model and identifies the most important threats to users and SNS providers. Building on threat analysis and modeling, this paper presents a privacy preservation model that incorporates individual self-protection and privacy-by-design approaches and uses the model to develop principles and countermeasures to protect user privacy. This study paves the way for analysis and design of privacy-preserving mechanisms on health-related SNS. PMID:26155953

  13. Results of an emergency response atmospheric dispersion model comparison using a state accepted statistical protocol

    SciTech Connect

    Ciolek, J.T. Jr.

    1993-10-01

    The Rocky Flats Plant, located approximately 26 km northwest of downtown Denver, Colorado, has developed an emergency response atmospheric dispersion model for complex terrain applications. Plant personnel would use the model, known as the Terrain-Responsive Atmospheric Code (TRAC) (Hodgin 1985) to project plume impacts and provide off-site protective action recommendations to the State of Colorado should a hazardous material release occur from the facility. The Colorado Department of Health (CDH) entered into an interagency agreement with the Rocky Flats Plant prime contractor, EG&G Rocky Flats, and the US Department of Energy to evaluate TRAC as an acceptable emergency response tool. After exhaustive research of similar evaluation processes from other emergency response and regulatory organizations, the interagency committee devised a formal acceptance process. The process contains an evaluation protocol (Hodgin and Smith 1992), descriptions of responsibilities, an identified experimental data set to use in the evaluation, and judgment criteria for model acceptance. The evaluation protocol is general enough to allow for different implementations. This paper explains one implementation, shows protocol results for a test case, and presents results of a comparison between versions of TRAC with different wind Field codes: a two dimensional mass consistent code called WINDS (Fosberg et al. 1976) that has been extended to three dimensions, and a fully 3 dimensional mass conserving code called NUATMOS (Ross and Smith 1987, Ross et al. 1988).

  14. Dannie Heineman Prize for Mathematical Physics Prize Lecture: Correlation Functions in Integrable Models: Ising Model and Monodromy Preserving Deformation

    NASA Astrophysics Data System (ADS)

    Miwa, Tetsuji

    2013-03-01

    Studies on integrable models in statistical mechanics and quantum field theory originated in the works of Bethe on the one-dimensional quantum spin chain and the work of Onsager on the two-dimensional Ising model. I will talk on the discovery in 1977 of the link between quantum field theory in the scaling limit of the two-dimensional Ising model and the theory of monodromy preserving linear ordinary differential equations. This work was the staring point of our journey with Michio Jimbo in integrable models, the journey which finally led us to the exact results on the correlation functions of quantum spin chains in 1992.

  15. Applying the Extended Technology Acceptance Model to the Use of Clickers in Student Learning: Some Evidence from Macroeconomics Classes

    ERIC Educational Resources Information Center

    Wu, Xiaoyu; Gao, Yuan

    2011-01-01

    This paper applies the extended technology acceptance model (exTAM) in information systems research to the use of clickers in student learning. The technology acceptance model (TAM) posits that perceived ease of use and perceived usefulness of technology influence users' attitudes toward using and intention to use technology. Research subsequent…

  16. The Acceptance Model of Intuitive Eating: A Comparison of Women in Emerging Adulthood, Early Adulthood, and Middle Adulthood

    ERIC Educational Resources Information Center

    Augustus-Horvath, Casey L.; Tylka, Tracy L.

    2011-01-01

    The acceptance model of intuitive eating (Avalos & Tylka, 2006) posits that body acceptance by others helps women appreciate their body and resist adopting an observer's perspective of their body, which contribute to their eating intuitively/adaptively. We extended this model by integrating body mass index (BMI) into its structure and…

  17. Fold-preserving electronic cleansing using a reconstruction model integrating material fractions and structural responses.

    PubMed

    Lee, Hyunna; Kim, Bohyoung; Lee, Jeongjin; Kim, Se Hyung; Shin, Yeong-Gil; Kim, Tae-Gong

    2013-06-01

    In this paper, we propose an electronic cleansing method using a novel reconstruction model for removing tagged materials (TMs) in computed tomography (CT) images. To address the partial volume (PV) and pseudoenhancement (PEH) effects concurrently, material fractions and structural responses are integrated into a single reconstruction model. In our approach, colonic components including air, TM, an interface layer between air and TM, and an interface layer between soft-tissue (ST) and TM (IL ST/TM ) are first segmented. For each voxel in IL ST/TM, the material fractions of ST and TM are derived using a two-material transition model, and the structural response to identify the folds submerged in the TM is calculated by the rut-enhancement function based on the eigenvalue signatures of the Hessian matrix. Then, the CT density value of each voxel in IL ST/TM is reconstructed based on both the material fractions and structural responses. The material fractions remove the aliasing artifacts caused by a PV effect in IL ST/TM effectively while the structural responses avoid the erroneous cleansing of the submerged folds caused by the PEH effect. Experimental results using ten clinical datasets demonstrated that the proposed method showed higher cleansing quality and better preservation of submerged folds than the previous method, which was validated by the higher mean density values and fold preservation rates for manually segmented fold regions. PMID:23335656

  18. Theory development in nursing and healthcare informatics: a model explaining and predicting information and communication technology acceptance by healthcare consumers.

    PubMed

    An, Ji-Young; Hayman, Laura L; Panniers, Teresa; Carty, Barbara

    2007-01-01

    About 110 million American adults are looking for health information and services on the Internet. Identification of the factors influencing healthcare consumers' technology acceptance is requisite to understanding their acceptance and usage behavior of online health information and related services. The purpose of this article is to describe the development of the Information and Communication Technology Acceptance Model (ICTAM). From the literature reviewed, ICTAM was developed with emphasis on integrating multidisciplinary perspectives from divergent frameworks and empirical findings into a unified model with regard to healthcare consumers' acceptance and usage behavior of information and services on the Internet. PMID:17703115

  19. EXpectation Propagation LOgistic REgRession (EXPLORER): Distributed Privacy-Preserving Online Model Learning

    PubMed Central

    Wang, Shuang; Jiang, Xiaoqian; Wu, Yuan; Cui, Lijuan; Cheng, Samuel; Ohno-Machado, Lucila

    2013-01-01

    We developed an EXpectation Propagation LOgistic REgRession (EXPLORER) model for distributed privacy-preserving online learning. The proposed framework provides a high level guarantee for protecting sensitive information, since the information exchanged between the server and the client is the encrypted posterior distribution of coefficients. Through experimental results, EXPLORER shows the same performance (e.g., discrimination, calibration, feature selection etc.) as the traditional frequentist Logistic Regression model, but provides more flexibility in model updating. That is, EXPLORER can be updated one point at a time rather than having to retrain the entire data set when new observations are recorded. The proposed EXPLORER supports asynchronized communication, which relieves the participants from coordinating with one another, and prevents service breakdown from the absence of participants or interrupted communications. PMID:23562651

  20. On Multiscale Modeling: Preserving Energy Dissipation Across the Scales with Consistent Handshaking Methods

    NASA Technical Reports Server (NTRS)

    Pineda, Evan J.; Bednarcyk, Brett A.; Arnold, Steven M.; Waas, Anthony M.

    2013-01-01

    A mesh objective crack band model was implemented within the generalized method of cells micromechanics theory. This model was linked to a macroscale finite element model to predict post-peak strain softening in composite materials. Although a mesh objective theory was implemented at the microscale, it does not preclude pathological mesh dependence at the macroscale. To ensure mesh objectivity at both scales, the energy density and the energy release rate must be preserved identically across the two scales. This requires a consistent characteristic length or localization limiter. The effects of scaling (or not scaling) the dimensions of the microscale repeating unit cell (RUC), according to the macroscale element size, in a multiscale analysis was investigated using two examples. Additionally, the ramifications of the macroscale element shape, compared to the RUC, was studied.

  1. Measuring the Moderating Effect of Gender and Age on E-Learning Acceptance in England: A Structural Equation Modeling Approach for an Extended Technology Acceptance Model

    ERIC Educational Resources Information Center

    Tarhini, Ali; Hone, Kate; Liu, Xiaohui

    2014-01-01

    The success of an e-learning intervention depends to a considerable extent on student acceptance and use of the technology. Therefore, it has become imperative for practitioners and policymakers to understand the factors affecting the user acceptance of e-learning systems in order to enhance the students' learning experience. Based on an extended…

  2. Privacy-preserving genomic testing in the clinic: a model using HIV treatment

    PubMed Central

    McLaren, Paul J.; Raisaro, Jean Louis; Aouri, Manel; Rotger, Margalida; Ayday, Erman; Bartha, István; Delgado, Maria B.; Vallet, Yannick; Günthard, Huldrych F.; Cavassini, Matthias; Furrer, Hansjakob; Doco-Lecompte, Thanh; Marzolini, Catia; Schmid, Patrick; Di Benedetto, Caroline; Decosterd, Laurent A.; Fellay, Jacques; Hubaux, Jean-Pierre; Telenti, Amalio

    2016-01-01

    Purpose: The implementation of genomic-based medicine is hindered by unresolved questions regarding data privacy and delivery of interpreted results to health-care practitioners. We used DNA-based prediction of HIV-related outcomes as a model to explore critical issues in clinical genomics. Genet Med 18 8, 814–822. Methods: We genotyped 4,149 markers in HIV-positive individuals. Variants allowed for prediction of 17 traits relevant to HIV medical care, inference of patient ancestry, and imputation of human leukocyte antigen (HLA) types. Genetic data were processed under a privacy-preserving framework using homomorphic encryption, and clinical reports describing potentially actionable results were delivered to health-care providers. Genet Med 18 8, 814–822. Results: A total of 230 patients were included in the study. We demonstrated the feasibility of encrypting a large number of genetic markers, inferring patient ancestry, computing monogenic and polygenic trait risks, and reporting results under privacy-preserving conditions. The average execution time of a multimarker test on encrypted data was 865 ms on a standard computer. The proportion of tests returning potentially actionable genetic results ranged from 0 to 54%. Genet Med 18 8, 814–822. Conclusions: The model of implementation presented herein informs on strategies to deliver genomic test results for clinical care. Data encryption to ensure privacy helps to build patient trust, a key requirement on the road to genomic-based medicine. Genet Med 18 8, 814–822. PMID:26765343

  3. A model-reduction approach in micromechanics of materials preserving the variational structure of constitutive relations

    NASA Astrophysics Data System (ADS)

    Michel, Jean-Claude; Suquet, Pierre

    2016-05-01

    In 2003 the authors proposed a model-reduction technique, called the Nonuniform Transformation Field Analysis (NTFA), based on a decomposition of the local fields of internal variables on a reduced basis of modes, to analyze the effective response of composite materials. The present study extends and improves on this approach in different directions. It is first shown that when the constitutive relations of the constituents derive from two potentials, this structure is passed to the NTFA model. Another structure-preserving model, the hybrid NTFA model of Fritzen and Leuschner, is analyzed and found to differ (slightly) from the primal NTFA model (it does not exhibit the same variational upper bound character). To avoid the "on-line" computation of local fields required by the hybrid model, new reduced evolution equations for the reduced variables are proposed, based on an expansion to second order (TSO) of the potential of the hybrid model. The coarse dynamics can then be entirely expressed in terms of quantities which can be pre-computed once for all. Roughly speaking, these pre-computed quantities depend only on the average and fluctuations per phase of the modes and of the associated stress fields. The accuracy of the new NTFA-TSO model is assessed by comparison with full-field simulations. The acceleration provided by the new coarse dynamics over the full-field computations (and over the hybrid model) is then spectacular, larger by three orders of magnitude than the acceleration due to the sole reduction of unknowns.

  4. Volume Preserved Mass-Spring Model with Novel Constraints for Soft Tissue Deformation.

    PubMed

    Duan, Yuping; Huang, Weimin; Chang, Huibin; Chen, Wenyu; Zhou, Jiayin; Teo, Soo Kng; Su, Yi; Chui, Chee Kong; Chang, Stephen

    2016-01-01

    An interactive surgical simulation system needs to meet three main requirements, speed, accuracy, and stability. In this paper, we present a stable and accurate method for animating mass-spring systems in real time. An integration scheme derived from explicit integration is used to obtain interactive realistic animation for a multiobject environment. We explore a predictor-corrector approach by correcting the estimation of the explicit integration in a poststep process. We introduce novel constraints on positions into the mass-spring model (MSM) to model the nonlinearity and preserve volume for the realistic simulation of the incompressibility. We verify the proposed MSM by comparing its deformations with the reference deformations of the nonlinear finite-element method. Moreover, experiments on porcine organs are designed for the evaluation of the multiobject deformation. Using a pair of freshly harvested porcine liver and gallbladder, the real organ deformations are acquired by computed tomography and used as the reference ground truth. Compared to the porcine model, our model achieves a 1.502 mm mean absolute error measured at landmark locations for cases with small deformation (the largest deformation is 49.109 mm) and a 3.639 mm mean absolute error for cases with large deformation (the largest deformation is 83.137 mm). The changes of volume for the two deformations are limited to 0.030% and 0.057%, respectively. Finally, an implementation in a virtual reality environment for laparoscopic cholecystectomy demonstrates that our model is capable to simulate large deformation and preserve volume in real-time calculations. PMID:25398184

  5. Development of a prediction model on the acceptance of electronic laboratory notebooks in academic environments.

    PubMed

    Kloeckner, Frederik; Farkas, Robert; Franken, Tobias; Schmitz-Rode, Thomas

    2014-04-01

    Documentation of research data plays a key role in the biomedical engineering innovation processes. It makes an important contribution to the protection of intellectual property, the traceability of results and fulfilling the regulatory requirement. Because of the increasing digitalization in laboratories, an electronic alternative to the commonly-used paper-bound notebooks could contribute to the production of sophisticated documentation. However, compared to in an industrial environment, the use of electronic laboratory notebooks is not widespread in academic laboratories. Little is known about the acceptance of an electronic documentation system and the underlying reasons for this. Thus, this paper aims to establish a prediction model on the potential preference and acceptance of scientists either for paper-based or electronic documentation. The underlying data for the analysis originate from an online survey of 101 scientists in industrial, academic and clinical environments. Various parameters were analyzed to identify crucial factors for the system preference using binary logistic regression. The analysis showed significant dependency between the documentation system preference and the supposed workload associated with the documentation system (p<0.006; odds ratio=58.543) and an additional personal component. Because of the dependency of system choice on specific parameters it is possible to predict the acceptance of an electronic laboratory notebook before implementation. PMID:24225123

  6. Computational model of collective nest selection by ants with heterogeneous acceptance thresholds

    PubMed Central

    Masuda, Naoki; O'shea-Wheller, Thomas A.; Doran, Carolina; Franks, Nigel R.

    2015-01-01

    Collective decision-making is a characteristic of societies ranging from ants to humans. The ant Temnothorax albipennis is known to use quorum sensing to collectively decide on a new home; emigration to a new nest site occurs when the number of ants favouring the new site becomes quorate. There are several possible mechanisms by which ant colonies can select the best nest site among alternatives based on a quorum mechanism. In this study, we use computational models to examine the implications of heterogeneous acceptance thresholds across individual ants in collective nest choice behaviour. We take a minimalist approach to develop a differential equation model and a corresponding non-spatial agent-based model. We show, consistent with existing empirical evidence, that heterogeneity in acceptance thresholds is a viable mechanism for efficient nest choice behaviour. In particular, we show that the proposed models show speed–accuracy trade-offs and speed–cohesion trade-offs when we vary the number of scouts or the quorum threshold. PMID:26543578

  7. Computational model of collective nest selection by ants with heterogeneous acceptance thresholds.

    PubMed

    Masuda, Naoki; O'shea-Wheller, Thomas A; Doran, Carolina; Franks, Nigel R

    2015-06-01

    Collective decision-making is a characteristic of societies ranging from ants to humans. The ant Temnothorax albipennis is known to use quorum sensing to collectively decide on a new home; emigration to a new nest site occurs when the number of ants favouring the new site becomes quorate. There are several possible mechanisms by which ant colonies can select the best nest site among alternatives based on a quorum mechanism. In this study, we use computational models to examine the implications of heterogeneous acceptance thresholds across individual ants in collective nest choice behaviour. We take a minimalist approach to develop a differential equation model and a corresponding non-spatial agent-based model. We show, consistent with existing empirical evidence, that heterogeneity in acceptance thresholds is a viable mechanism for efficient nest choice behaviour. In particular, we show that the proposed models show speed-accuracy trade-offs and speed-cohesion trade-offs when we vary the number of scouts or the quorum threshold. PMID:26543578

  8. Solitons in a baby-Skyrme model with invariance under area-preserving diffeomorphisms

    NASA Astrophysics Data System (ADS)

    Gisiger, T.; Paranjape, M. B.

    1997-06-01

    We study the properties of soliton solutions in an analogue of the Skyrme model in 2+1 dimensions whose Lagrangian contains the Skyrme term and the mass term, but no usual kinetic term. The model admits a symmetry under area-preserving diffeomorphisms. We solve the dynamical equations of motion analytically for the case of spinning isolated baryon-type solitons. We take fully into account the induced deformation of the spinning Skyrmions and the consequent modification of its moment of inertia to give an analytical example of related numerical behavior found by Piette, Schroers, and Zakrzewski. We solve the equations of motion also for the case of an infinite, open string, and a closed annular string. In each case, the solitons are of finite extent, so called ``compactons,'' being exactly the vacuum outside a compact region. We end with indications on the scattering of baby Skyrmions, as well as some considerations as the properties of solitons on a curved space.

  9. Frequency-Preserved Acoustic Diode Model with High Forward-Power-Transmission Rate

    NASA Astrophysics Data System (ADS)

    Liu, Chang; Du, Zongliang; Sun, Zhi; Gao, Huajian; Guo, Xu

    2015-06-01

    The acoustic diode (AD) can provide brighter and clearer ultrasound images by eliminating acoustic disturbances caused by sound waves traveling in two directions at the same time and interfering with each other. Such an AD could give designers new flexibility in making ultrasonic sources like those used in medical imaging or nondestructive testing. However, current AD designs, based on nonlinear effects, only partially fill this role by converting sound to a new frequency and blocking any backward flow of the original frequency. In this work, an AD model that preserves the frequencies of acoustic waves and has a relatively high forward-power-transmission rate is proposed. Theoretical analysis indicates that the proposed AD has forward, reverse, and breakdown characteristics very similar to electrical diodes. The significant rectifying effect of the proposed AD is verified numerically through a one-dimensional example. Possible schemes for experimental realization of this model as well as more complex and efficient AD designs are also discussed.

  10. Demyelination and axonal preservation in a transgenic mouse model of Pelizaeus-Merzbacher disease

    PubMed Central

    Edgar, Julia M; McCulloch, Mailis C; Montague, Paul; Brown, Angus M; Thilemann, Sebastian; Pratola, Laura; Gruenenfelder, Fredrik I; Griffiths, Ian R; Nave, Klaus-Armin

    2010-01-01

    It is widely thought that demyelination contributes to the degeneration of axons and, in combination with acute inflammatory injury, is responsible for progressive axonal loss and persistent clinical disability in inflammatory demyelinating disease. In this study we sought to characterize the relationship between demyelination, inflammation and axonal transport changes using a Plp1-transgenic mouse model of Pelizaeus-Merzbacher disease. In the optic pathway of this non-immune mediated model of demyelination, myelin loss progresses from the optic nerve head towards the brain, over a period of months. Axonal transport is functionally perturbed at sites associated with local inflammation and ‘damaged’ myelin. Surprisingly, where demyelination is complete, naked axons appear well preserved despite a significant reduction of axonal transport. Our results suggest that neuroinflammation and/or oligodendrocyte dysfunction are more deleterious for axonal health than demyelination per se, at least in the short term. PMID:20091761

  11. Symmetry-preserving contact interaction model for heavy-light mesons

    NASA Astrophysics Data System (ADS)

    Serna, F. E.; Brito, M. A.; Krein, G.

    2016-01-01

    We use a symmetry-preserving regularization method of ultraviolet divergences in a vector-vector contact interaction model for low-energy QCD. The contact interaction is a representation of nonperturbative kernels used Dyson-Schwinger and Bethe-Salpeter equations. The regularization method is based on a subtraction scheme that avoids standard steps in the evaluation of divergent integrals that invariably lead to symmetry violation. Aiming at the study of heavy-light mesons, we have implemented the method to the pseudoscalar π and K mesons. We have solved the Dyson-Schwinger equation for the u, d and s quark propagators, and obtained the bound-state Bethe-Salpeter amplitudes in a way that the Ward-Green-Takahashi identities reflecting global symmetries of the model are satisfied for arbitrary routing of the momenta running in loop integrals.

  12. Revisiting models of crustal growth; the role of preservation and destruction

    NASA Astrophysics Data System (ADS)

    Roberts, Nick; Spencer, Christopher

    2015-04-01

    The rate of growth of the continental crust remains a topic of much debate. Individual continents and cratons show apparent episodic magmatic activity and associated continental growth. Because our archive of Earth's history is locked up in the continental crust, most records of Earth history similarly have an episodic nature to them. One long-standing model has been that these episodes of continental growth are related to both large mantle upwelling and mantle overturn events. Another model that has been in and out of favour, is that continental growth was rapid in the early Earth history, and that net growth has been near-zero since at least the Mesoarchaean. Crustal growth rates based on modelling of isotopic systems tend to feature an increasing volume through time, with a faster rate up to the Meso- to Neoarchaean. As well as being derived from the mantle, continental crust can also be returned to the mantle. The net continental growth rate is a balance between this addition and loss. A problem with many crustal growth models is that they are based on the record preserved today. Although attempts have been made to account for intra-continental recycling, continental loss back into the mantle is generally unaccounted for. For this reason, many crustal growth curves can be considered a minimum. With an approach using Hf and O isotopes in zircon, it can be shown that at least 50% of the current volume of continental crust was formed by 3 Ga, and that of this current volume, at least 45% has been recycled intra-crustally. Current estimates of crustal mass-balance suggest that continental addition is similar to rates of continental loss. But how far back in time has this been the case? If plate tectonics and deep subduction have been around since the late Archaean, then it is likely that rates of reworking have been high since this time also. The hotly debated question: what style of plate tectonics and continental growth mechanisms existed throughout the Archaean

  13. Asymptotic-preserving Lagrangian approach for modeling anisotropic transport in magnetized plasmas

    NASA Astrophysics Data System (ADS)

    Chacon, Luis; Del-Castillo-Negrete, Diego

    2012-03-01

    Modeling electron transport in magnetized plasmas is extremely challenging due to the extreme anisotropy between parallel (to the magnetic field) and perpendicular directions (the transport-coefficient ratio χ/χ˜10^10 in fusion plasmas). Recently, a novel Lagrangian Green's function method has been proposedfootnotetextD. del-Castillo-Negrete, L. Chac'on, PRL, 106, 195004 (2011); D. del-Castillo-Negrete, L. Chac'on, Phys. Plasmas, submitted (2011) to solve the local and non-local purely parallel transport equation in general 3D magnetic fields. The approach avoids numerical pollution, is inherently positivity-preserving, and is scalable algorithmically (i.e., work per degree-of-freedom is grid-independent). In this poster, we discuss the extension of the Lagrangian Green's function approach to include perpendicular transport terms and sources. We present an asymptotic-preserving numerical formulation, which ensures a consistent numerical discretization temporally and spatially for arbitrary χ/χ ratios. We will demonstrate the potential of the approach with various challenging configurations, including the case of transport across a magnetic island in cylindrical geometry.

  14. Retinal structure and function preservation by polysaccharides of wolfberry in a mouse model of retinal degeneration

    PubMed Central

    Wang, Ke; Xiao, Jia; Peng, Bo; Xing, Feiyue; So, Kwok-Fai; Tipoe, George L.; Lin, Bin

    2014-01-01

    Retinitis pigmentosa (RP) is a heterogeneous group of inherited disorders caused by mutations in a variety of genes that are mostly expressed by rod cells, which results in initial death of rod photoreceptors followed by gradual death of cone photoreceptors. RP is currently untreatable and usually leads to partial or complete blindness. Here, we explored the potential neuroprotective effects of polysaccharides of wolfberry, which are long known to possess primary beneficial properties in the eyes, on photoreceptor apoptosis in the rd10 mouse model of RP. We found that these polysaccharides provided long-term morphological and functional preservation of photoreceptors and improved visual behaviors in rd10 mice. Moreover, we demonstrated that polysaccharides exerted neuroprotective effects through antioxidant, anti-inflammatory and anti-apoptotic mechanisms. Furthermore, we identified that polysaccharides modulated inflammation and apoptosis partly through inhibition of NF-κB and HIF-1α expressions, respectively. Overall, we demonstrated the synergistic protective effects of polysaccharides in preserving photoreceptors against degeneration in rd10 mice. Our study provides rationale and scientific support on using polysaccharides of wolfberry as one supplementary treatment of RP patients in the future. PMID:25535040

  15. An Investigation of Employees' Use of E-Learning Systems: Applying the Technology Acceptance Model

    ERIC Educational Resources Information Center

    Lee, Yi-Hsuan; Hsieh, Yi-Chuan; Chen, Yen-Hsun

    2013-01-01

    The purpose of this study is to apply the technology acceptance model to examine the employees' attitudes and acceptance of electronic learning (e-learning) systems in organisations. This study examines four factors (organisational support, computer self-efficacy, prior experience and task equivocality) that are believed to influence…

  16. An Elaboration Likelihood Model Based Longitudinal Analysis of Attitude Change during the Process of IT Acceptance via Education Program

    ERIC Educational Resources Information Center

    Lee, Woong-Kyu

    2012-01-01

    The principal objective of this study was to gain insight into attitude changes occurring during IT acceptance from the perspective of elaboration likelihood model (ELM). In particular, the primary target of this study was the process of IT acceptance through an education program. Although the Internet and computers are now quite ubiquitous, and…

  17. An Exploration of Student Internet Use in India: The Technology Acceptance Model and the Theory of Planned Behaviour

    ERIC Educational Resources Information Center

    Fusilier, Marcelline; Durlabhji, Subhash

    2005-01-01

    Purpose: The purpose of this paper is to explore behavioral processes involved in internet technology acceptance and use with a sample in India, a developing country that can potentially benefit from greater participation in the web economy. Design/methodology/approach - User experience was incorporated into the technology acceptance model (TAM)…

  18. Feature, design intention and constraint preservation for direct modeling of 3D freeform surfaces

    NASA Astrophysics Data System (ADS)

    Fu, Luoting; Kara, Levent Burak; Shimada, Kenji

    2012-06-01

    Direct modeling has recently emerged as a suitable approach for 3D free-form shape modeling in industrial design. It has several advantages over the conventional, parametric modeling techniques, including natural user interactions, as well as the underlying, automatic feature-preserving shape deformation algorithms. However, current direct modeling packages still lack several capabilities critical for product design, such as managing aesthetic design intentions, and enforcing dimensional, geometric constraints. In this paper, we describe a novel 3D surface editing system capable of jointly accommodating aesthetic design intentions expressed in the form of surface painting and color-coded annotations, as well as engineering constraints expressed as dimensions. The proposed system is built upon differential coordinates and constrained least squares, and is intended for conceptual design that involves frequent shape tuning and explorations. We also provide an extensive review of the state-of-the-art direct modeling approaches for 3D mesh-based, freeform surfaces, with an emphasis on the two broad categories of shape deformation algorithms developed in the relevant field of geometric modeling. [Figure not available: see fulltext.

  19. Minimal atmospheric finite-mode models preserving symmetry and generalized Hamiltonian structures

    NASA Astrophysics Data System (ADS)

    Bihlo, Alexander; Staufer, Johannes

    2011-03-01

    A typical problem with the conventional Galerkin approach for the construction of finite-mode models is to keep structural properties unaffected in the process of discretization. We present two examples of finite-mode approximations that in some respect preserve the geometric attributes inherited from their continuous models: a three-component model of the barotropic vorticity equation known as Lorenz' maximum simplification equations [E.N. Lorenz, Maximum simplification of the dynamic equations, Tellus 12 (3) (1960) 243-254] and a six-component model of the two-dimensional Rayleigh-Bénard convection problem. It is reviewed that the Lorenz-1960 model respects both the maximal set of admitted point symmetries and an extension of the noncanonical Hamiltonian form (Nambu form). In a similar fashion, it is proved that the famous Lorenz-1963 model violates the structural properties of the Saltzman equations and hence cannot be considered as the maximum simplification of the Rayleigh-Bénard convection problem. Using a six-component truncation, we show that it is again possible to retain both symmetries and the Nambu representation in the course of discretization. The conservative part of this six-component reduction is related to the Lagrange top equations. Dissipation is incorporated using a metric tensor.

  20. Testing the Electronic Personal Health Record Acceptance Model by Nurses for Managing Their Own Health

    PubMed Central

    Trinkoff, A.M.; Storr, C.L.; Wilson, M.L.; Gurses, A.P.

    2015-01-01

    Summary Background To our knowledge, no evidence is available on health care professionals’ use of electronic personal health records (ePHRs) for their health management. We therefore focused on nurses’ personal use of ePHRs using a modified technology acceptance model. Objectives To examine (1) the psychometric properties of the ePHR acceptance model, (2) the associations of perceived usefulness, ease of use, data privacy and security protection, and perception of self as health-promoting role models to nurses’ own ePHR use, and (3) the moderating influences of age, chronic illness and medication use, and providers’ use of electronic health record (EHRs) on the associations between the ePHR acceptance constructs and ePHR use. Methods A convenience sample of registered nurses, those working in one of 12 hospitals in the Maryland and Washington, DC areas and members of the nursing informatics community (AMIA and HIMSS), were invited to respond to an anonymous online survey; 847 responded. Multiple logistic regression identified associations between the model constructs and ePHR use, and the moderating effect. Results Overall, ePHRs were used by 47%. Sufficient reliability for all scales was found. Three constructs were significantly related to nurses’ own ePHR use after adjusting for covariates: usefulness, data privacy and security protection, and health-promoting role model. Nurses with providers that used EHRs who perceived a higher level of data privacy and security protection had greater odds of ePHR use than those whose providers did not use EHRs. Older nurses with a higher self-perception as health-promoting role models had greater odds of ePHR use than younger nurses. Conclusions Nurses who use ePHRs for their personal health might promote adoption by the general public by serving as health-promoting role models. They can contribute to improvements in patient education and ePHR design, and serve as crucial resources when working with their

  1. Development of a Health Information Technology Acceptance Model Using Consumers’ Health Behavior Intention

    PubMed Central

    2012-01-01

    Background For effective health promotion using health information technology (HIT), it is mandatory that health consumers have the behavioral intention to measure, store, and manage their own health data. Understanding health consumers’ intention and behavior is needed to develop and implement effective and efficient strategies. Objective To develop and verify the extended Technology Acceptance Model (TAM) in health care by describing health consumers’ behavioral intention of using HIT. Methods This study used a cross-sectional descriptive correlational design. We extended TAM by adding more antecedents and mediating variables to enhance the model’s explanatory power and to make it more applicable to health consumers’ behavioral intention. Additional antecedents and mediating variables were added to the hypothetical model, based on their theoretical relevance, from the Health Belief Model and theory of planned behavior, along with the TAM. We undertook structural equation analysis to examine the specific nature of the relationship involved in understanding consumers’ use of HIT. Study participants were 728 members recruited from three Internet health portals in Korea. Data were collected by a Web-based survey using a structured self-administered questionnaire. Results The overall fitness indices for the model developed in this study indicated an acceptable fit of the model. All path coefficients were statistically significant. This study showed that perceived threat, perceived usefulness, and perceived ease of use significantly affected health consumers’ attitude and behavioral intention. Health consumers’ health status, health belief and concerns, subjective norm, HIT characteristics, and HIT self-efficacy had a strong indirect impact on attitude and behavioral intention through the mediators of perceived threat, perceived usefulness, and perceived ease of use. Conclusions An extended TAM in the HIT arena was found to be valid to describe health

  2. Electronic Health Record Patient Portal Adoption by Health Care Consumers: An Acceptance Model and Survey

    PubMed Central

    2016-01-01

    Background The future of health care delivery is becoming more citizen centered, as today’s user is more active, better informed, and more demanding. Worldwide governments are promoting online health services, such as electronic health record (EHR) patient portals and, as a result, the deployment and use of these services. Overall, this makes the adoption of patient-accessible EHR portals an important field to study and understand. Objective The aim of this study is to understand the factors that drive individuals to adopt EHR portals. Methods We applied a new adoption model using, as a starting point, Ventkatesh's Unified Theory of Acceptance and Use of Technology in a consumer context (UTAUT2) by integrating a new construct specific to health care, a new moderator, and new relationships. To test the research model, we used the partial least squares (PLS) causal modelling approach. An online questionnaire was administrated. We collected 360 valid responses. Results The statistically significant drivers of behavioral intention are performance expectancy (beta=.200; t=3.619), effort expectancy (beta=.185; t=2.907), habit (beta=.388; t=7.320), and self-perception (beta=.098; t=2.285). The predictors of use behavior are habit (beta=0.206; t=2.752) and behavioral intention (beta=0.258; t=4.036). The model explained 49.7% of the variance in behavioral intention and 26.8% of the variance in use behavior. Conclusions Our research helps to understand the desired technology characteristics of EHR portals. By testing an information technology acceptance model, we are able to determine what is more valued by patients when it comes to deciding whether to adopt EHR portals or not. The inclusion of specific constructs and relationships related to the health care consumer area also had a significant impact on understanding the adoption of EHR portals. PMID:26935646

  3. Using the VERHIB model to reconstruct palaeo-vegetation from preserved biomarker patterns

    NASA Astrophysics Data System (ADS)

    van Loon, Emiel; Jansen, Boris

    2010-05-01

    One of the most detailed methods available to date to reconstruct past vegetation dynamics is the analysis of fossil pollen. Unfortunately, fossil pollen analysis does not distinguish beyond family or generic level in most cases, while its spatial resolution is limited amongst others by windblown dispersal of pollen, affecting the accuracy of pollen-based reconstructions of UFL positions. To overcome these limitations, we developed a new method based on the analysis of plant-specific groups of biomarkers preserved in suitable archives, such as peat deposits, that are unraveled into the plant species of origin by the newly developed VERHIB model. It consists of a linear forward model to describe the way in which a certain vegetation development over time at a certain location results in accumulation of biomarkers in a suitable archive such as marine or lacustrine sediment, peat deposit or soil. An inversion of the forward model is used to reconstruct paleovegetation on the basis of the observed accumulated biomarker signal. Tikhonov regularization is used to cope with non-uniqueness resulting from the combination of fine-scale output resolution and limited sample numbers. The Bayesian quality control technique by Ingleby & Lorenc is used to deal with heterogeneity in observational errors. Hard as well as soft constraints, derived from biological principles and dynamical models are included to ensure model results are always within physically and biologically realistic limits. Sequential Quadratic Programming is used as the solution technique for the combined non-linear constrained and regularized problem in VERHIB. Here we describe the model and present its first application to reconstruct palaeo-vegetation based on patterns of plant-specific n-alcohols and n-alkanes with chain lengths of C20-C36 preserved in a peat sequence from a biodiversity hotspot of montane rainforest in the Ecuadorian Andes. We show how a combination of the new biomarker application using

  4. Modelling dose distribution in tubing and cable using CYLTRAN and ACCEPT Monte Carlo simulation code

    SciTech Connect

    Weiss, D.E.; Kensek, R.P.

    1993-12-31

    One of the difficulties in the irradiation of non-slab geometries, such as a tube, is the uneven penetration of the electrons. A simple model of the distribution of dose in a tube or cable in relationship to voltage, composition, wall thickness and diameter can be mapped using the cylinder geometry provided for in the ITS/CYLTRAN code, complete with automatic subzoning. The reality of more complex 3D geometry to include effects of window foil, backscattering fixtures and beam scanning angles can be more completely accounted for by using the ITS/ACCEPT code with a line source update and a system of intersecting wedges to define input zones for mapping dose distributions in a tube. Thus, all of the variables that affect dose distribution can be modelled without the need to run time consuming and costly factory experiments. The effects of composition changes on dose distribution can also be anticipated.

  5. Symmetry preserving eigenvalue embedding in finite-element model updating of vibrating structures

    NASA Astrophysics Data System (ADS)

    Carvalho, Joao B.; Datta, Biswa N.; Lin, Wen-Wei; Wang, Chern-Shuh

    2006-03-01

    The eigenvalue embedding problem addressed in this paper is the one of reassigning a few troublesome eigenvalues of a symmetric finite-element model to some suitable chosen ones, in such a way that the updated model remains symmetric and the remaining large number of eigenvalues and eigenvectors of the original model is to remain unchanged. The problem naturally arises in stabilizing a large-scale system or combating dangerous vibrations, which can be responsible for undesired phenomena such as resonance, in large vibrating structures. A new computationally efficient and symmetry preserving method and associated theories are presented in this paper. The model is updated using low-rank symmetric updates and other computational requirements of the method include only simple operations such as matrix multiplications and solutions of low-order algebraic linear systems. These features make the method practical for large-scale applications. The results of numerical experiments on the simulated data obtained from the Boeing company and on some benchmark examples are presented to show the accuracy of the method. Computable error bounds for the updated matrices are also given by means of rigorous mathematical analysis.

  6. Modelling of biogas extraction at an Italian landfill accepting mechanically and biologically treated municipal solid waste.

    PubMed

    Calabrò, Paolo S; Orsi, Sirio; Gentili, Emiliano; Carlo, Meoni

    2011-12-01

    This paper presents the results of the modelling of the biogas extraction in a full-scale Italian landfill by the USEPA LandGEM model and the Andreottola-Cossu approach. The landfill chosen for this research ('Il Fossetto' plant, Monsummano Terme, Italy) had accepted mixed municipal raw waste for about 15 years. In the year 2003 a mechanical biological treatment (MBT) was implemented and starting from the end of the year 2006, the recirculation in the landfill of the concentrated leachate coming from the internal membrane leachate treatment plant was put into practice. The USEPA LandGEM model and the Andreottola-Cossu approach were chosen since they require only input data routinely acquired during landfill management (waste amount and composition) and allow a simplified calibration, therefore they are potentially useful for practical purposes such as landfill gas management. The results given by the models are compared with measured data and analysed in order to verify the impact of MBT on biogas production; moreover, the possible effects of the recirculation of the concentrated leachate are discussed. The results clearly show how both models can adequately fit measured data even after MBT implementation. Model performance was significantly reduced for the period after the beginning of recirculation of concentrated leachate when the probable inhibition of methane production, due to the competition between methanogens and sulfate-reducing bacteria, significantly influenced the biogas production and composition. PMID:21930528

  7. Probabilistic reliability modeling for oil exploration & production (E&P) facilities in the tallgrass prairie preserve.

    PubMed

    Zambrano, Lyda; Sublette, Kerry; Duncan, Kathleen; Thoma, Greg

    2007-10-01

    The aging domestic oil production infrastructure represents a high risk to the environment because of the type of fluids being handled (oil and brine) and the potential for accidental release of these fluids into sensitive ecosystems. Currently, there is not a quantitative risk model directly applicable to onshore oil exploration and production (E&P) facilities. We report on a probabilistic reliability model created for onshore exploration and production (E&P) facilities. Reliability theory, failure modes and effects analysis (FMEA), and event trees were used to develop the model estimates of the failure probability of typical oil production equipment. Monte Carlo simulation was used to translate uncertainty in input parameter values to uncertainty in the model output. The predicted failure rates were calibrated to available failure rate information by adjusting probability density function parameters used as random variates in the Monte Carlo simulations. The mean and standard deviation of normal variate distributions from which the Weibull distribution characteristic life was chosen were used as adjustable parameters in the model calibration. The model was applied to oil production leases in the Tallgrass Prairie Preserve, Oklahoma. We present the estimated failure probability due to the combination of the most significant failure modes associated with each type of equipment (pumps, tanks, and pipes). The results show that the estimated probability of failure for tanks is about the same as that for pipes, but that pumps have much lower failure probability. The model can provide necessary equipment reliability information for proactive risk management at the lease level by providing quantitative information to base allocation of maintenance resources to high-risk equipment that will minimize both lost production and ecosystem damage. PMID:18076499

  8. Acetylation Preserves Retinal Ganglion Cell Structure and Function in a Chronic Model of Ocular Hypertension

    PubMed Central

    Alsarraf, Oday; Fan, Jie; Dahrouj, Mohammad; Chou, C. James; Yates, Phillip W.; Crosson, Craig E.

    2014-01-01

    Purpose. The current studies investigate if the histone deacetylase (HDAC) inhibitor, valproic acid (VPA), can limit retinal ganglion cell (RGC) degeneration in an ocular-hypertensive rat model. Methods. Intraocular pressure (IOP) was elevated unilaterally in Brown Norway rats by hypertonic saline injection. Rats received either vehicle or VPA (100 mg/kg) treatment for 28 days. Retinal ganglion cell function and number were assessed by pattern electroretinogram (pERG) and retrograde FluoroGold labeling. Western blotting and a fluorescence assay were used for determination of histone H3 acetylation and HDAC activity, respectively, at 3-day, 1-week, and 2-week time points. Results. Hypertonic saline injections increased IOPs by 7 to 14 mm Hg. In vehicle-treated animals, ocular hypertension resulted in a 29.1% and 39.4% decrease in pERG amplitudes at 2 and 4 weeks, respectively, and a 42.9% decrease in mean RGC density at 4 weeks. In comparison, VPA treatment yielded significant amplitude preservation at 2 and 4 weeks and showed significant RGC density preservation at 4 weeks. No significant difference in RGC densities or IOPs was measured between control eyes of vehicle- and VPA-treated rats. In ocular-hypertensive eyes, class I HDAC activity was significantly elevated within 1 week (13.3 ± 2.2%) and histone H3 acetylation was significantly reduced within 2 weeks following the induction of ocular hypertension. Conclusions. Increase in HDAC activity is a relatively early retinal event induced by elevated IOP, and suppressing HDAC activity can protect RGCs from ocular-hypertensive stress. Together these data provide a basis for developing HDAC inhibitors for the treatment of optic neuropathies. PMID:25358731

  9. Comparing Cognitive, Metacognitive, and Acceptance and Commitment Therapy Models of Depression: a Longitudinal Study Survey.

    PubMed

    Ruiz, Francisco J; Odriozola-González, Paula

    2015-01-01

    This study analyzed the interrelationships between key constructs of cognitive therapy (CT; depressogenic schemas), metacognitive therapy (MCT; dysfunctional metacognitive beliefs), and acceptance and commitment therapy (ACT; psychological inflexibility) in the prediction of depressive symptoms. With a lapse of nine months, 106 nonclinical participants responded twice to an anonymous online survey containing the following questionnaires: the Depression subscale of the Depression Anxiety and Stress Scales (DASS), the Dysfunctional Attitude Scale Revised (DAS-R), the Positive beliefs, Negative beliefs and Need to control subscales of the Metacognitions Questionnaire-30 (MCQ-30), and the Acceptance and Action Questionnaire - II (AAQ-II). Results showed that when controlling for baseline levels of depressive symptoms and demographic variables, psychological inflexibility longitudinally mediated the effect of depressogenic schemas (path ab = .023, SE = .010; 95% BC CI [.008, .048]) and dysfunctional metacognitive beliefs on depressive symptoms (positive metacognitive beliefs: path ab = .052, SE = .031; 95% BC CI [.005, .134]; negative metacognitive beliefs: path ab = .087, SE = .049; 95% BC CI [.016, .214]; need to control: path ab = .087, SE = .051; 95% BC CI [.013, .220]). Results are discussed emphasizing the role of psychological inflexibility in the CT and MCT models of depression. PMID:26076977

  10. Finite Element Surface Registration Incorporating Curvature, Volume Preservation, and Statistical Model Information

    PubMed Central

    Lüthi, Marcel; Vetter, Thomas

    2013-01-01

    We present a novel method for nonrigid registration of 3D surfaces and images. The method can be used to register surfaces by means of their distance images, or to register medical images directly. It is formulated as a minimization problem of a sum of several terms representing the desired properties of a registration result: smoothness, volume preservation, matching of the surface, its curvature, and possible other feature images, as well as consistency with previous registration results of similar objects, represented by a statistical deformation model. While most of these concepts are already known, we present a coherent continuous formulation of these constraints, including the statistical deformation model. This continuous formulation renders the registration method independent of its discretization. The finite element discretization we present is, while independent of the registration functional, the second main contribution of this paper. The local discontinuous Galerkin method has not previously been used in image registration, and it provides an efficient and general framework to discretize each of the terms of our functional. Computational efficiency and modest memory consumption are achieved thanks to parallelization and locally adaptive mesh refinement. This allows for the first time the use of otherwise prohibitively large 3D statistical deformation models. PMID:24187581

  11. Consumer acceptance and stability of spray dried betanin in model juices.

    PubMed

    Kaimainen, Mika; Laaksonen, Oskar; Järvenpää, Eila; Sandell, Mari; Huopalahti, Rainer

    2015-11-15

    Spray dried beetroot powder was used to colour model juices, and the consumer acceptance of the juices and stability of the colour during storage at 60 °C, 20 °C, 4 °C, and -20 °C were studied. The majority of the consumers preferred the model juices coloured with anthocyanins or beetroot extract over model juices coloured with spray dried beetroot powder. The consumers preferred more intensely coloured samples over lighter samples. Spray dried betanin samples were described as 'unnatural' and 'artificial' whereas the colour of beetroot extract was described more 'natural' and 'real juice'. No beetroot-derived off-odours or off-flavours were perceived in the model juices coloured with beetroot powder. Colour stability in model juices was greatly dependent on storage temperature with better stability at lower temperatures. Colour stability in the spray dried powder was very good at 20 °C. Betacyanins from beetroot could be a potential colourant for food products that are stored cold. PMID:25977043

  12. Where there's smoke: Cigarette use, social acceptability, and spatial approaches to multilevel modeling.

    PubMed

    O'Connell, Heather A

    2015-09-01

    I contribute to understandings of how context is related to individual outcomes by assessing the added value of combining multilevel and spatial modeling techniques. This methodological approach leads to substantive contributions to the smoking literature, including improved clarity on the central contextual factors and the examination of one manifestation of the social acceptability hypothesis. For this analysis I use restricted-use natality data from the Vital Statistics, and county-level data from the 2005-9 ACS. Critically, the results suggest that spatial considerations are still relevant in a multilevel framework. In addition, I argue that spatial processes help explain the relationships linking racial/ethnic minority concentration to lower overall odds of smoking. PMID:26188587

  13. WHERE THERE’S SMOKE: CIGARETTE USE, SOCIAL ACCEPTABILITY, AND SPATIAL APPROACHES TO MULTILEVEL MODELING

    PubMed Central

    O’Connell, Heather A.

    2015-01-01

    I contribute to understandings of how context is related to individual outcomes by assessing the added value of combining multilevel and spatial modeling techniques. This methodological approach leads to substantive contributions to the smoking literature, including improved clarity on the central contextual factors and the examination of one manifestation of the social acceptability hypothesis. For this analysis I use restricted-use natality data from the Vital Statistics, and county-level data from the 2005–9 ACS. Critically, the results suggest that spatial considerations are still relevant in a multilevel framework. In addition, I argue that spatial processes help explain the relationships linking racial/ethnic minority concentration to lower overall odds of smoking. PMID:26188587

  14. [Skin and tissue bank: Operational model for the recovery and preservation of tissues and skin allografts].

    PubMed

    Martínez-Flores, Francisco; Sandoval-Zamora, Hugo; Machuca-Rodriguez, Catalina; Barrera-López, Araceli; García-Cavazos, Ricardo; Madinaveitia-Villanueva, Juan Antonio

    2016-01-01

    Tissue storage is a medical process that is in the regulation and homogenisation phase in the scientific world. The international standards require the need to ensure safety and efficacy of human allografts such as skin and other tissues. The activities of skin and tissues banks currently involve their recovery, processing, storage and distribution, which are positively correlated with technological and scientific advances present in current biomedical sciences. A description is presented of the operational model of Skin and Tissue Bank at INR as successful case for procurement, recovery and preservation of skin and tissues for therapeutic uses, with high safety and biological quality. The essential and standard guidelines are presented as keystones for a tissue recovery program based on scientific evidence, and within an ethical and legal framework, as well as to propose a model for complete overview of the donation of tissues and organ programs in Mexico. Finally, it concludes with essential proposals for improving the efficacy of transplantation of organs and tissue programs. PMID:26259741

  15. A rat model of slow Wallerian degeneration (WldS) with improved preservation of neuromuscular synapses.

    PubMed

    Adalbert, Robert; Gillingwater, Thomas H; Haley, Jane E; Bridge, Katherine; Beirowski, Bogdan; Berek, Livia; Wagner, Diana; Grumme, Daniela; Thomson, Derek; Celik, Arzu; Addicks, Klaus; Ribchester, Richard R; Coleman, Michael P

    2005-01-01

    The slow Wallerian degeneration phenotype, Wld(S), which delays Wallerian degeneration and axon pathology for several weeks, has so far been studied only in mice. A rat model would have several advantages. First, rats model some human disorders better than mice. Second, the larger body size of rats facilitates more complex surgical manipulations. Third, rats provide a greater yield of tissue for primary culture and biochemical investigations. We generated transgenic Wld(S) rats expressing the Ube4b/Nmnat1 chimeric gene in the central and peripheral nervous system. As in Wld(S) mice, their axons survive up to 3 weeks after transection and remain functional for at least 1 week. Protection of axotomized nerve terminals is stronger than in mice, particularly in one line, where 95-100% of neuromuscular junctions remained intact and functional after 5 days. Furthermore, the loss of synaptic phenotype with age was much less in rats than in mice. Thus, the slow Wallerian degeneration phenotype can be transferred to another mammalian species and synapses may be more effectively preserved after axotomy in species with longer axons. PMID:15654865

  16. Solitons in a baby-Skyrme model with invariance under area-preserving diffeomorphisms

    SciTech Connect

    Gisiger, T.; Paranjape, M.B.

    1997-06-01

    We study the properties of soliton solutions in an analogue of the Skyrme model in 2+1 dimensions whose Lagrangian contains the Skyrme term and the mass term, but no usual kinetic term. The model admits a symmetry under area-preserving diffeomorphisms. We solve the dynamical equations of motion analytically for the case of spinning isolated baryon-type solitons. We take fully into account the induced deformation of the spinning Skyrmions and the consequent modification of its moment of inertia to give an analytical example of related numerical behavior found by Piette, Schroers, and Zakrzewski. We solve the equations of motion also for the case of an infinite, open string, and a closed annular string. In each case, the solitons are of finite extent, so called {open_quotes}compactons,{close_quotes} being exactly the vacuum outside a compact region. We end with indications on the scattering of baby Skyrmions, as well as some considerations as the properties of solitons on a curved space. {copyright} {ital 1997} {ital The American Physical Society}

  17. Mesenchymal stem cells preserve neonatal right ventricular function in a porcine model of pressure overload.

    PubMed

    Wehman, Brody; Sharma, Sudhish; Pietris, Nicholas; Mishra, Rachana; Siddiqui, Osama T; Bigham, Grace; Li, Tieluo; Aiello, Emily; Murthi, Sarah; Pittenger, Mark; Griffith, Bartley; Kaushal, Sunjay

    2016-06-01

    Limited therapies exist for patients with congenital heart disease (CHD) who develop right ventricular (RV) dysfunction. Bone marrow-derived mesenchymal stem cells (MSCs) have not been evaluated in a preclinical model of pressure overload, which simulates the pathophysiology relevant to many forms of CHD. A neonatal swine model of RV pressure overload was utilized to test the hypothesis that MSCs preserve RV function and attenuate ventricular remodeling. Immunosuppressed Yorkshire swine underwent pulmonary artery banding to induce RV dysfunction. After 30 min, human MSCs (1 million cells, n = 5) or placebo (n = 5) were injected intramyocardially into the RV free wall. Serial transthoracic echocardiography monitored RV functional indices including 2D myocardial strain analysis. Four weeks postinjection, the MSC-treated myocardium had a smaller increase in RV end-diastolic area, end-systolic area, and tricuspid vena contracta width (P < 0.01), increased RV fractional area of change, and improved myocardial strain mechanics relative to placebo (P < 0.01). The MSC-treated myocardium demonstrated enhanced neovessel formation (P < 0.0001), superior recruitment of endogenous c-kit+ cardiac stem cells to the RV (P < 0.0001) and increased proliferation of cardiomyocytes (P = 0.0009) and endothelial cells (P < 0.0001). Hypertrophic changes in the RV were more pronounced in the placebo group, as evidenced by greater wall thickness by echocardiography (P = 0.008), increased cardiomyocyte cross-sectional area (P = 0.001), and increased expression of hypertrophy-related genes, including brain natriuretic peptide, β-myosin heavy chain and myosin light chain. Additionally, MSC-treated myocardium demonstrated increased expression of the antihypertrophy secreted factor, growth differentiation factor 15 (GDF15), and its downstream effector, SMAD 2/3, in cultured neonatal rat cardiomyocytes and in the porcine RV myocardium. This is the first report of the use of MSCs as a therapeutic

  18. The development of a model for predicting passenger acceptance of short-haul air transportation systems

    NASA Technical Reports Server (NTRS)

    Kuhlthau, A. R.; Jacobson, I. D.

    1977-01-01

    Meaningful criteria and methodology for assessing, particularly in the area of ride quality, the potential acceptability to the traveling public of present and future transportation systems were investigated. Ride quality was found to be one of the important variables affecting the decision of users of air transportation, and to be influenced by several environmental factors, especially motion, noise, pressure, temperature, and seating. Models were developed to quantify the relationship of subjective comfort to all of these parameters and then were exercised for a variety of situations. Passenger satisfaction was found to be strongly related to ride quality and was so modeled. A computer program was developed to assess the comfort and satisfaction levels of passengers on aircraft subjected to arbitrary flight profiles over arbitrary terrain. A model was deduced of the manner in which passengers integrate isolated segments of a flight to obtain an overall trip comfort rating. A method was established for assessing the influence of other links (e.g., access, terminal conditions) in the overall passenger trip.

  19. Invasive surgery reduces infarct size and preserves cardiac function in a porcine model of myocardial infarction

    PubMed Central

    van Hout, Gerardus PJ; Teuben, Michel PJ; Heeres, Marjolein; de Maat, Steven; de Jong, Renate; Maas, Coen; Kouwenberg, Lisanne HJA; Koenderman, Leo; van Solinge, Wouter W; de Jager, Saskia CA; Pasterkamp, Gerard; Hoefer, Imo E

    2015-01-01

    Reperfusion injury following myocardial infarction (MI) increases infarct size (IS) and deteriorates cardiac function. Cardioprotective strategies in large animal MI models often failed in clinical trials, suggesting translational failure. Experimentally, MI is induced artificially and the effect of the experimental procedures may influence outcome and thus clinical applicability. The aim of this study was to investigate if invasive surgery, as in the common open chest MI model affects IS and cardiac function. Twenty female landrace pigs were subjected to MI by transluminal balloon occlusion. In 10 of 20 pigs, balloon occlusion was preceded by invasive surgery (medial sternotomy). After 72 hrs, pigs were subjected to echocardiography and Evans blue/triphenyl tetrazoliumchloride double staining to determine IS and area at risk. Quantification of IS showed a significant IS reduction in the open chest group compared to the closed chest group (IS versus area at risk: 50.9 ± 5.4% versus 69.9 ± 3.4%, P = 0.007). End systolic LV volume and LV ejection fraction measured by echocardiography at follow-up differed significantly between both groups (51 ± 5 ml versus 65 ± 3 ml, P = 0.033; 47.5 ± 2.6% versus 38.8 ± 1.2%, P = 0.005). The inflammatory response in the damaged myocardium did not differ between groups. This study indicates that invasive surgery reduces IS and preserves cardiac function in a porcine MI model. Future studies need to elucidate the effect of infarct induction technique on the efficacy of pharmacological therapies in large animal cardioprotection studies. PMID:26282710

  20. Asymptotic-preserving Lagrangian approach for modeling anisotropic transport in magnetized plasmas for arbitrary magnetic fields

    NASA Astrophysics Data System (ADS)

    Chacon, Luis; Del-Castillo-Negrete, Diego; Hauck, Cory

    2012-10-01

    Modeling electron transport in magnetized plasmas is extremely challenging due to the extreme anisotropy between parallel (to the magnetic field) and perpendicular directions (χ/χ˜10^10 in fusion plasmas). Recently, a Lagrangian Green's function approach, developed for the purely parallel transport case,footnotetextD. del-Castillo-Negrete, L. Chac'on, PRL, 106, 195004 (2011)^,footnotetextD. del-Castillo-Negrete, L. Chac'on, Phys. Plasmas, 19, 056112 (2012) has been extended to the anisotropic transport case in the tokamak-ordering limit with constant density.footnotetextL. Chac'on, D. del-Castillo-Negrete, C. Hauck, JCP, submitted (2012) An operator-split algorithm is proposed that allows one to treat Eulerian and Lagrangian components separately. The approach is shown to feature bounded numerical errors for arbitrary χ/χ ratios, which renders it asymptotic-preserving. In this poster, we will present the generalization of the Lagrangian approach to arbitrary magnetic fields. We will demonstrate the potential of the approach with various challenging configurations, including the case of transport across a magnetic island in cylindrical geometry.

  1. Area-preserving maps models of gyroaveraged E×B chaotic transport

    SciTech Connect

    Fonseca, J. D. da Caldas, I. L.; Castillo-Negrete, D. del

    2014-09-15

    Discrete maps have been extensively used to model 2-dimensional chaotic transport in plasmas and fluids. Here we focus on area-preserving maps describing finite Larmor radius (FLR) effects on E × B chaotic transport in magnetized plasmas with zonal flows perturbed by electrostatic drift waves. FLR effects are included by gyro-averaging the Hamiltonians of the maps which, depending on the zonal flow profile, can have monotonic or non-monotonic frequencies. In the limit of zero Larmor radius, the monotonic frequency map reduces to the standard Chirikov-Taylor map, and in the case of non-monotonic frequency, the map reduces to the standard nontwist map. We show that in both cases FLR leads to chaos suppression, changes in the stability of fixed points, and robustness of transport barriers. FLR effects are also responsible for changes in the phase space topology and zonal flow bifurcations. Dynamical systems methods based on the counting of recurrences times are used to quantify the dependence on the Larmor radius of the threshold for the destruction of transport barriers.

  2. Preservice Teachers' Acceptance of ICT Integration in the Classroom: Applying the UTAUT Model

    ERIC Educational Resources Information Center

    Birch, A.; Irvine, V.

    2009-01-01

    In this study, the researchers explore the factors that influence preservice teachers' acceptance of information and communication technology (ICT) integration in the classroom. The Unified Theory of Acceptance and Use of Technology (UTAUT) was developed by Venkatesh et al. ["MIS Quarterly, 27"(3), 425-478] in 2003 and shown to outperform eight…

  3. Determinants of Intention to Use eLearning Based on the Technology Acceptance Model

    ERIC Educational Resources Information Center

    Punnoose, Alfie Chacko

    2012-01-01

    The purpose of this study was to find some of the predominant factors that determine the intention of students to use eLearning in the future. Since eLearning is not just a technology acceptance decision but also involves cognition, this study extended its search beyond the normal technology acceptance variables into variables that could affect…

  4. A Quantitative Examination of User Experience as an Antecedent to Student Perception in Technology Acceptance Modeling

    ERIC Educational Resources Information Center

    Butler, Rory

    2013-01-01

    Internet-enabled mobile devices have increased the accessibility of learning content for students. Given the ubiquitous nature of mobile computing technology, a thorough understanding of the acceptance factors that impact a learner's intention to use mobile technology as an augment to their studies is warranted. Student acceptance of mobile…

  5. Empirical Testing of a Theoretical Extension of the Technology Acceptance Model: An Exploratory Study of Educational Wikis

    ERIC Educational Resources Information Center

    Liu, Xun

    2010-01-01

    This study extended the technology acceptance model and empirically tested the new model with wikis, a new type of educational technology. Based on social cognitive theory and the theory of planned behavior, three new variables, wiki self-efficacy, online posting anxiety, and perceived behavioral control, were added to the original technology…

  6. Learning with Interactive Whiteboards: Determining the Factors on Promoting Interactive Whiteboards to Students by Technology Acceptance Model

    ERIC Educational Resources Information Center

    Kilic, Eylem; Güler, Çetin; Çelik, H. Eray; Tatli, Cemal

    2015-01-01

    Purpose: The purpose of this study is to investigate the factors which might affect the intention to use interactive whiteboards (IWBs) by university students, using Technology Acceptance Model by the structural equation modeling approach. The following hypothesis guided the current study: H1. There is a positive relationship between IWB…

  7. Cardiac preservation is enhanced in a heterotopic rat transplant model by supplementing the nitric oxide pathway.

    PubMed Central

    Pinsky, D J; Oz, M C; Koga, S; Taha, Z; Broekman, M J; Marcus, A J; Liao, H; Naka, Y; Brett, J; Cannon, P J

    1994-01-01

    Nitric oxide (NO) is a novel biologic messenger with diverse effects but its role in organ transplantation remains poorly understood. Using a porphyrinic microsensor, the first direct measurements of coronary vascular and endocardial NO production were made. NO was measured directly in the effluent of preserved, heterotopically transplanted rat hearts stimulated with L-arginine and bradykinin; NO concentrations fell from 2.1 +/- 0.4 microM for freshly explanted hearts to 0.7 +/- 0.2 and 0.2 +/- 0.08 microM for hearts preserved for 19 and 38 h, respectively. NO levels were increased by SOD, suggesting a role for superoxide-mediated destruction of NO. Consistent with these data, addition of the NO donor nitroglycerin (NTG) to a balanced salt preservation solution enhanced graft survival in a time- and dose-dependent manner, with 92% of hearts supplemented with NTG surviving 12 h of preservation versus only 17% in its absence. NTG similarly enhanced preservation of hearts stored in University of Wisconsin solution, the clinical standard for preservation. Other stimulators of the NO pathway, including nitroprusside, L-arginine, or 8-bromoguanosine 3',5' monophosphate, also enhanced graft survival, whereas the competitive NO synthase antagonist NG-monomethyl-L-arginine was associated with poor preservation. Likely mechanisms whereby supplementation of the NO pathway enhanced preservation included increased blood flow to the reperfused graft and decreased graft leukostasis. NO was also measured in endothelial cells subjected to hypoxia/reoxygenation and detected based on its ability to inhibit thrombin-mediated platelet aggregation and serotonin release. NO became undetectable in endothelial cells exposed to hypoxia followed by reoxygenation and was restored to normoxic levels on addition of SOD. These studies suggest that the NO pathway fails during preservation/transplantation because of formation of oxygen free radicals during reperfusion, which quench available NO

  8. Physician Acceptance of a Physician-Pharmacist Collaborative Treatment Model for Hypertension Management in Primary Care.

    PubMed

    Smith, Steven M; Hasan, Michaela; Huebschmann, Amy G; Penaloza, Richard; Schorr-Ratzlaff, Wagner; Sieja, Amber; Roscoe, Nicholai; Trinkley, Katy E

    2015-09-01

    Physician-pharmacist collaborative care (PPCC) is effective in improving blood pressure (BP) control, but primary care provider (PCP) engagement in such models has not been well-studied. The authors analyzed data from PPCC referrals to 108 PCPs, for patients with uncontrolled hypertension, assessing the proportion of referral requests approved, disapproved, and not responded to, and reasons for disapproval. Of 2232 persons with uncontrolled hypertension, PPCC referral requests were sent for 1516 (67.9%): 950 (62.7%) were approved, 406 (26.8%) were disapproved, and 160 (10.6%) received no response. Approval rates differed widely by PCP with a median approval rate of 75% (interquartile range, 41%-100%). The most common reasons for disapproval were: PCP prefers to manage hypertension (19%), and BP controlled per PCP (18%); 8% of cases were considered too complex for PPCC. Provider acceptance of a PPCC hypertension clinic was generally high and sustained but varied widely among PCPs. No single reason for disapproval predominated. PMID:26032586

  9. Cone survival and preservation of visual acuity in an animal model of retinal degeneration.

    PubMed

    Piano, Ilaria; Novelli, Elena; Gasco, Paolo; Ghidoni, Riccardo; Strettoi, Enrica; Gargini, Claudia

    2013-06-01

    The prevention of cone loss during retinal degeneration is a major goal of most therapeutic strategies in retinal degenerative diseases. An intriguing issue in the current research in this field is to understand why a genetic mutation that affects rods eventually leads to cone death. The main objective of the present study was to investigate to what extent rescuing rods from degeneration affects the survival of cones and prevents functional impairment of the visual performance. To this purpose, we compared rod and cone viabilities by both ex vivo and in vivo determinations in the rd10 mutant mouse, a validated model of human retinitis pigmentosa. The ex vivo experiments included morphological and biochemical tests, whereas in vivo studies compared the rod-mediated scotopic with the cone-mediated photopic electroretinogram. We also determined the overall visual performance by behaviorally testing the visual acuity (VA). The electroretinogram measurements showed that the kinetics of the photopic response in rd10 mice was slowed down with respect to the age-paired wild-type at a very early stage of the disease, when rods were still present and responsive. We then tested cone viability and function under a pharmacological scheme previously shown to prolong rod survival. The treatment consisted of eye drop administration of myriocin, an inhibitor of the biosynthesis of ceramide, a powerful proapoptotic messenger. The results of biochemical, morphological and functional assays converged to show that, in treated rd10 mice cone photoreceptors, the inner retina and overall visual performance were preserved well after rod death. PMID:23551187

  10. Noncyclic geometric quantum computation and preservation of entanglement for a two-qubit Ising model

    NASA Astrophysics Data System (ADS)

    Rangani Jahromi, H.; Amniat-Talab, M.

    2015-10-01

    After presenting an exact analytical solution of time-dependent Schrödinger equation, we study the dynamics of entanglement for a two-qubit Ising model. One of the spin qubits is driven by a static magnetic field applied in the direction of the Ising interaction, while the other is coupled with a rotating magnetic field. We also investigate how the entanglement can be controlled by changing the external parameters. Because of the important role of maximally entangled Bell states in quantum communication, we focus on the generalized Bell states as the initial states of the system. It is found that the entanglement evolution is independent of the initial Bell states. Moreover, we can preserve the initial maximal entanglement by adjusting the angular frequency of the rotating field or controlling the exchange coupling between spin qubits. Besides, our calculation shows that the entanglement dynamics is unaffected by the static magnetic field imposed in the direction of the Ising interaction. This is an interesting result, because, as we shall show below, this driving field can be used to control and manipulate the noncyclic geometric phase without affecting the system entanglement. Besides, the nonadiabatic and noncyclic geometric phase for evolved states of the present system are calculated and described in detail. In order to identify the unusable states for quantum communication, completely deviated from the initial maximally entangled states, we also study the fidelity between the initial Bell state and the evolved state of the system. Interestingly, we find that these unusable states can be detected by geometric quantum computation.

  11. Integrating Social Capital Theory, Social Cognitive Theory, and the Technology Acceptance Model to Explore a Behavioral Model of Telehealth Systems

    PubMed Central

    Tsai, Chung-Hung

    2014-01-01

    Telehealth has become an increasingly applied solution to delivering health care to rural and underserved areas by remote health care professionals. This study integrated social capital theory, social cognitive theory, and the technology acceptance model (TAM) to develop a comprehensive behavioral model for analyzing the relationships among social capital factors (social capital theory), technological factors (TAM), and system self-efficacy (social cognitive theory) in telehealth. The proposed framework was validated with 365 respondents from Nantou County, located in Central Taiwan. Structural equation modeling (SEM) was used to assess the causal relationships that were hypothesized in the proposed model. The finding indicates that elderly residents generally reported positive perceptions toward the telehealth system. Generally, the findings show that social capital factors (social trust, institutional trust, and social participation) significantly positively affect the technological factors (perceived ease of use and perceived usefulness respectively), which influenced usage intention. This study also confirmed that system self-efficacy was the salient antecedent of perceived ease of use. In addition, regarding the samples, the proposed model fitted considerably well. The proposed integrative psychosocial-technological model may serve as a theoretical basis for future research and can also offer empirical foresight to practitioners and researchers in the health departments of governments, hospitals, and rural communities. PMID:24810577

  12. Evaluation of Galleria mellonella larvae as an in vivo model for assessing the relative toxicity of food preservative agents.

    PubMed

    Maguire, Ronan; Duggan, Orla; Kavanagh, Kevin

    2016-06-01

    Larvae of Galleria mellonella are widely used for evaluating the virulence of microbial pathogens and for measuring the efficacy of anti-microbial agents and produce results comparable to those that can be obtained using mammals. In this work, the suitability of using G. mellonella larvae to measure the relative toxicity of a variety of food preservatives was evaluated. The response of larvae to eight commonly used food preservatives (potassium nitrate, potassium nitrite, potassium sorbate, sodium benzoate, sodium nitrate, sodium chloride, sodium nitrite and sodium acetate) administered by feeding or by intra-haemocoel injection was measured. A significant correlation between the LD50 (R (2) = 0.8766, p = 0.0006) and LD80 (R (2) = 0.7629, p = 0.0046) values obtained due to oral or intra-haemocoel administration of compounds was established. The response of HEp-2 cells to the food preservatives was determined, and a significant correlation (R (2) = 0.7217, p = 0.0076) between the LD50 values of the compounds administered by feeding in larvae with the IC50 values of the compounds in HEp-2 cells was established. A strong correlation between the LD50 values of the eight food preservatives in G. mellonella larvae and rats (R (2) = 0.6506, p = 0.0156) was demonstrated. The results presented here indicate that G. mellonella larvae may be used as a model to evaluate the relative toxicity of food preservatives, and the results show a strong positive correlation to those obtained using established cell culture and mammalian models. PMID:27122324

  13. A Lagrangian model for soil water dynamics: can we step beyond Richard's equation while preserving capillarity as first order control?

    NASA Astrophysics Data System (ADS)

    Zehe, Erwin; Jackisch, Conrad

    2016-04-01

    Water storage in the unsaturated zone is controlled by capillary forces which increase nonlinearly with decreasing pore size, because water acts as a wetting fluid in soil. The standard approach to represent capillary and gravity controlled soil water dynamics is the Darcy-Richards equation in combination with suitable soil water characteristics. This continuum model essentially assumes capillarity controlled diffusive fluxes to dominate soil water dynamics under local thermodynamic equilibrium conditions. Today we know that the assumptions of local equilibrium conditions e.g. and a mainly diffusive flow are often not appropriate, particularly during rainfall events in structured soils. Rapid or preferential flow imply a strong local disequilibrium and imperfect mixing between a fast fraction of soil water, traveling in interconnected coarse pores or non-capillary macropores, and the slower diffusive flow in finer fractions of the pore space. Although various concepts have been proposed to overcome the inability of the Darcy - Richards concept to cope with not-well mixed preferential flow, we still lack an approach that is commonly accepted. Notwithstanding the listed short comings, one should not mistake the limitations of the Richards equation with non-importance of capillary forces in soil. Without capillarity infiltrating rainfall would drain into groundwater bodies, leaving an empty soil as the local equilibrium state - there would be no soil water dynamics at all, probably even no terrestrial vegetation without capillary forces. Better alternatives for the Darcy-Richards approach are thus highly desirable, as long they preserve the grain of "truth" about capillarity as first order control. Here we propose such an alternative approach to simulate soil moisture dynamics in a stochastic and yet physical way. Soil water is represented by particles of constant mass, which travel according to the Itô form of the Fokker Planck equation. The model concept builds on

  14. Preserving Appalachian Heritage: A Model for Oral History Research and Teaching.

    ERIC Educational Resources Information Center

    La Lone, Mary B.

    1999-01-01

    An oral history project on the coal mining heritage of southwest Virginia's New River Valley developed from a partnership between Radford University and a grassroots community group interested in cultural preservation. Publication products, benefits to participating college students, and reasons for the project's success are discussed. Contains 26…

  15. The Theory of Planned Behavior (TPB) and Pre-Service Teachers' Technology Acceptance: A Validation Study Using Structural Equation Modeling

    ERIC Educational Resources Information Center

    Teo, Timothy; Tan, Lynde

    2012-01-01

    This study applies the theory of planned behavior (TPB), a theory that is commonly used in commercial settings, to the educational context to explain pre-service teachers' technology acceptance. It is also interested in examining its validity when used for this purpose. It has found evidence that the TPB is a valid model to explain pre-service…

  16. Factors of Online Learning Adoption: A Comparative Juxtaposition of the Theory of Planned Behaviour and the Technology Acceptance Model

    ERIC Educational Resources Information Center

    Ndubisi, Nelson

    2006-01-01

    Organisational investments in information technologies have increased significantly in the past few decades. All around the globe and in Malaysia particularly, a number of educational institutions are experimenting with e-learning. Adopting the theory of planned behaviour (TPB) and the technology acceptance model (TAM) this article tries to…

  17. Preservation Assessment and Disaster Response Plan.

    ERIC Educational Resources Information Center

    Wisdom, Mark

    This paper addresses the preservation needs unique to small libraries, where the majority of special collections exist. A preservation survey of the Herrick Memorial Library (Wellington, OH) was conducted to ascertain the condition of its 45,000 holdings and develop a practical low-cost disaster plan. Using accepted preservation survey criteria,…

  18. Uncertainty preserving patch-based online modeling for 3D model acquisition and integration from passive motion imagery

    NASA Astrophysics Data System (ADS)

    Tang, Hao; Chang, Peng; Molina, Edgardo; Zhu, Zhigang

    2012-06-01

    In both military and civilian applications, abundant data from diverse sources captured on airborne platforms are often available for a region attracting interest. Since the data often includes motion imagery streams collected from multiple platforms flying at different altitudes, with sensors of different field of views (FOVs), resolutions, frame rates and spectral bands, it is imperative that a cohesive site model encompassing all the information can be quickly built and presented to the analysts. In this paper, we propose to develop an Uncertainty Preserving Patch-based Online Modeling System (UPPOMS) leading towards the automatic creation and updating of a cohesive, geo-registered, uncertaintypreserving, efficient 3D site terrain model from passive imagery with varying field-of-views and phenomenologies. The proposed UPPOMS has the following technical thrusts that differentiate our approach from others: (1) An uncertaintypreserved, patch-based 3D model is generated, which enables the integration of images captured with a mixture of NFOV and WFOV and/or visible and infrared motion imagery sensors. (2) Patch-based stereo matching and multi-view 3D integration are utilized, which are suitable for scenes with many low texture regions, particularly in mid-wave infrared images. (3) In contrast to the conventional volumetric algorithms, whose computational and storage costs grow exponentially with the amount of input data and the scale of the scene, the proposed UPPOMS system employs an online algorithmic pipeline, and scales well to large amount of input data. Experimental results and discussions of future work will be provided.

  19. Modeling nurses' acceptance of bar coded medication administration technology at a pediatric hospital

    PubMed Central

    Brown, Roger L; Scanlon, Matthew C; Karsh, Ben-Tzion

    2012-01-01

    Objective To identify predictors of nurses' acceptance of bar coded medication administration (BCMA). Design Cross-sectional survey of registered nurses (N=83) at an academic pediatric hospital that recently implemented BCMA. Methods Surveys assessed seven BCMA-related perceptions: ease of use; usefulness for the job; social influence from non-specific others to use BCMA; training; technical support; usefulness for patient care; and social influence from patients/families. An all possible subset regression procedure with five goodness-of-fit indicators was used to identify which set of perceptions best predicted BCMA acceptance (intention to use, satisfaction). Results Nurses reported a moderate perceived ease of use and low perceived usefulness of BCMA. Nurses perceived moderate-or-higher social influence to use BCMA and had moderately positive perceptions of BCMA-related training and technical support. Behavioral intention to use BCMA was high, but satisfaction was low. Behavioral intention to use was best predicted by perceived ease of use, perceived social influence from non-specific others, and perceived usefulness for patient care (56% of variance explained). Satisfaction was best predicted by perceived ease of use, perceived usefulness for patient care, and perceived social influence from patients/families (76% of variance explained). Discussion Variation in and low scores on ease of use and usefulness are concerning, especially as these variables often correlate with acceptance, as found in this study. Predicting acceptance benefited from using a broad set of perceptions and adapting variables to the healthcare context. Conclusion Success with BCMA and other technologies can benefit from assessing end-user acceptance and elucidating the factors promoting acceptance and use. PMID:22661559

  20. Investigating IT Faculty Resistance to Learning Management System Adoption Using Latent Variables in an Acceptance Technology Model

    PubMed Central

    Bousbahi, Fatiha; Alrazgan, Muna Saleh

    2015-01-01

    To enhance instruction in higher education, many universities in the Middle East have chosen to introduce learning management systems (LMS) to their institutions. However, this new educational technology is not being used at its full potential and faces resistance from faculty members. To investigate this phenomenon, we conducted an empirical research study to uncover factors influencing faculty members' acceptance of LMS. Thus, in the Fall semester of 2014, Information Technology faculty members were surveyed to better understand their perceptions of the incorporation of LMS into their courses. The results showed that personal factors such as motivation, load anxiety, and organizational support play important roles in the perception of the usefulness of LMS among IT faculty members. These findings suggest adding these constructs in order to extend the Technology acceptance model (TAM) for LMS acceptance, which can help stakeholders of the university to implement the use of this system. This may assist in planning and evaluating the use of e-learning. PMID:26491712

  1. Investigating IT Faculty Resistance to Learning Management System Adoption Using Latent Variables in an Acceptance Technology Model.

    PubMed

    Bousbahi, Fatiha; Alrazgan, Muna Saleh

    2015-01-01

    To enhance instruction in higher education, many universities in the Middle East have chosen to introduce learning management systems (LMS) to their institutions. However, this new educational technology is not being used at its full potential and faces resistance from faculty members. To investigate this phenomenon, we conducted an empirical research study to uncover factors influencing faculty members' acceptance of LMS. Thus, in the Fall semester of 2014, Information Technology faculty members were surveyed to better understand their perceptions of the incorporation of LMS into their courses. The results showed that personal factors such as motivation, load anxiety, and organizational support play important roles in the perception of the usefulness of LMS among IT faculty members. These findings suggest adding these constructs in order to extend the Technology acceptance model (TAM) for LMS acceptance, which can help stakeholders of the university to implement the use of this system. This may assist in planning and evaluating the use of e-learning. PMID:26491712

  2. Preservation Environments

    NASA Technical Reports Server (NTRS)

    Moore, Reagan W.

    2004-01-01

    The long-term preservation of digital entities requires mechanisms to manage the authenticity of massive data collections that are written to archival storage systems. Preservation environments impose authenticity constraints and manage the evolution of the storage system technology by building infrastructure independent solutions. This seeming paradox, the need for large archives, while avoiding dependence upon vendor specific solutions, is resolved through use of data grid technology. Data grids provide the storage repository abstractions that make it possible to migrate collections between vendor specific products, while ensuring the authenticity of the archived data. Data grids provide the software infrastructure that interfaces vendor-specific storage archives to preservation environments.

  3. Integrating Telemedicine for Disaster Response: Testing the Emergency Telemedicine Technology Acceptance Model

    ERIC Educational Resources Information Center

    Davis, Theresa M.

    2013-01-01

    Background: There is little evidence that technology acceptance is well understood in healthcare. The hospital environment is complex and dynamic creating a challenge when new technology is introduced because it impacts current processes and workflows which can significantly affect patient care delivery and outcomes. This study tested the effect…

  4. Using the UTAUT Model to Examine the Acceptance Behavior of Synchronous Collaboration to Support Peer Translation

    ERIC Educational Resources Information Center

    Liu, Yi Chun; Huang, Yong-Ming

    2015-01-01

    The teaching of translation has received considerable attention in recent years. Research on translation in collaborative learning contexts, however, has been less studied. In this study, we use a tool of synchronous collaboration to assist students in experiencing a peer translation process. Afterward, the unified theory of acceptance and use of…

  5. WebCT--The Quasimoderating Effect of Perceived Affective Quality on an Extending Technology Acceptance Model

    ERIC Educational Resources Information Center

    Sanchez-Franco, Manuel J.

    2010-01-01

    Perceived affective quality is an attractive area of research in Information System. Specifically, understanding the intrinsic and extrinsic individual factors and interaction effects that influence Information and Communications Technology (ICT) acceptance and adoption--in higher education--continues to be a focal interest in learning research.…

  6. Perceived Playfulness, Gender Differences and Technology Acceptance Model in a Blended Learning Scenario

    ERIC Educational Resources Information Center

    Padilla-Melendez, Antonio; del Aguila-Obra, Ana Rosa; Garrido-Moreno, Aurora

    2013-01-01

    The importance of technology for education is increasing year-by-year at all educational levels and particularly for Universities. This paper reexamines one important determinant of technology acceptance and use, such as perceived playfulness in the context of a blended learning setting and reveals existing gender differences. After a literature…

  7. An Investigation of University Student Readiness Towards M-Learning Using Technology Acceptance Model

    ERIC Educational Resources Information Center

    Iqbal, Shakeel; Bhatti, Zeeshan Ahmed

    2015-01-01

    M-learning is learning delivered via mobile devices and mobile technology. The research indicates that this medium of learning has potential to enhance formal as well as informal learning. However, acceptance of m-learning greatly depends upon the personal attitude of students towards this medium; therefore this study focuses only on the…

  8. Exploring Students' Intention to Use LINE for Academic Purposes Based on Technology Acceptance Model

    ERIC Educational Resources Information Center

    Van De Bogart, Willard; Wichadee, Saovapa

    2015-01-01

    The LINE application is often conceived as purely social space; however, the authors of this paper wanted to determine if it could be used for academic purposes. In this study, we examined how undergraduate students accepted LINE in terms of using it for classroom-related activities (e.g., submit homework, follow up course information queries,…

  9. Adult Role Models: Feasibility, Acceptability, and Initial Outcomes for Sex Education

    ERIC Educational Resources Information Center

    Colarossi, Lisa; Silver, Ellen Johnson; Dean, Randa; Perez, Amanda; Rivera, Angelic

    2014-01-01

    The authors present the feasibility and acceptability of a parent sexuality education program led by peer educators in community settings. They also report the results of an outcome evaluation with 71 parents who were randomized to the intervention or a control group and surveyed one month prior to and six months after the four-week intervention.…

  10. Urine Preservative

    NASA Technical Reports Server (NTRS)

    Smith, Scott M. (Inventor); Nillen, Jeannie (Inventor)

    2001-01-01

    Disclosed is CPG, a combination of a chlorhexidine salt (such as chlorhexidine digluconate, chlorhexidine diacetate, or chlorhexidine dichloride) and n-propyl gallate that can be used at ambient temperatures as a urine preservative.

  11. Modelling the growth/no growth boundary of Zygosaccharomyces bailii in acidic conditions: a contribution to the alternative method to preserve foods without using chemical preservatives.

    PubMed

    Dang, T D T; Mertens, L; Vermeulen, A; Geeraerd, A H; Van Impe, J F; Debevere, J; Devlieghere, F

    2010-01-31

    The aim of the study was to develop mathematical models describing growth/no growth (G/NG) boundaries of the highly resistant food spoilage yeast-Zygosaccharomyces bailii-in different environmental conditions, taking acidified sauces as the target product. By applying these models, the stability of products with characteristics within the investigated pH, a(w) and acetic acid ranges can be evaluated. Besides, the well-defined no growth regions can be used in the development of guidelines regarding formulation of new shelf-stable foods without using chemical preservatives, which would facilitate the innovation of additive-free products. Experiments were performed at different temperatures and periods (22 degrees C for 45 and 60days, 30 degrees C for 45days) in 150 modified Sabouraud media characterized by high amount of sugars (glucose and fructose, 15% (w/v)), acetic acid (0.0-2.5% (v/v), 6 levels), pH (3.0-5.0, 5 levels) and a(w) (0.93-0.97, 5 levels). These time and temperature combinations were chosen as they are commonly applied for shelf-stable foods. The media were inoculated with ca. 4.5 log CFU/ml and yeast growth was monitored daily using optical density measurements. Every condition was examined in 20 replicates in order to yield accurate growth probabilities. Three separate ordinary logistic regression models were developed for different tested temperatures and incubation time. The total acetic acid concentration was considered as variable for all models. In general, when one intrinsic inhibitory factor became more stringent, the G/NG boundary shifted to less stressful conditions of the other two factors, resulting in enlarged no growth zones. Abrupt changes of growth probability often occurred around the transition zones (between growth and no growth regions), which indicates that minor variations in environmental conditions near the G/NG boundaries can cause a significant impact on the growth probability. When comparing growth after 45days between the

  12. Preventing repetition of attempted suicide--I. Feasibility (acceptability, adherence, and effectiveness) of a Baerum-model like aftercare.

    PubMed

    Hvid, Marianne; Wang, August G

    2009-01-01

    Repetition after attempted suicide is high with only limited research been put into effect studies. The Baerum-model from Norway offers a practical and affordable intervention. Our aim was to study the acceptability and effectiveness of a Baerum-model like intervention after attempted suicide using a quasi-experimental design. During a period in 2004, attempted suicide patients were offered follow-up care by a rapid-response outreach programme, an intervention lasting 6 months; a control group was established prospectively from a similar period in 2002. The design was an intent-to-treat analysis. The outcome was measured by: 1) participation by acceptance and adherence, 2) repetition of suicide attempt and suicide, and 3) including the number of repetitive acts in 1 year after the attempted suicide episode. Follow-up period was 1 year. Participation was 70%. There was a significant lower repetition rate in the intervention group, where the proportion of repetitive patients fell from 34% to 14%. There were also fewer suicidal acts, in total 37 acts in 58 patients in the control group and 22 acts in 93 patients for the intervention group. We have concluded that the outreach programme has a good feasibility because of high acceptability and adherence, and has an acceptable effectiveness in the follow up period of 1 year. We have therefore initiated a similar study using a randomization design in order to study efficacy. PMID:19016074

  13. Stress exposure and generation: A conjoint longitudinal model of body dysmorphic symptoms, peer acceptance, popularity, and victimization.

    PubMed

    Webb, Haley J; Zimmer-Gembeck, Melanie J; Mastro, Shawna

    2016-09-01

    This study examined the bidirectional (conjoint) longitudinal pathways linking adolescents' body dysmorphic disorder (BDD) symptoms with self- and peer-reported social functioning. Participants were 367 Australian students (45.5% boys, mean age=12.01 years) who participated in two waves of a longitudinal study with a 12-month lag between assessments. Participants self-reported their symptoms characteristic of BDD, and perception of peer acceptance. Classmates reported who was popular and victimized in their grade, and rated their liking (acceptance) of their classmates. In support of both stress exposure and stress generation models, T1 victimization was significantly associated with more symptoms characteristic of BDD at T2 relative to T1, and higher symptom level at T1 was associated with lower perceptions of peer acceptance at T2 relative to T1. These results support the hypothesized bidirectional model, whereby adverse social experiences negatively impact symptoms characteristic of BDD over time, and symptoms also exacerbate low perceptions of peer-acceptance. PMID:27236472

  14. Bed-form climb models to analyze geometry and preservation potential of clastic facies and erosional surfaces

    SciTech Connect

    Larue, D.K.; Martinez, P.A.

    1989-01-01

    Based on a combination of Walther's Law of Facies and bed-form climb theory, the authors propose a model that explains how erosion surfaces and vertical sequences of clastic strata are preserved where deposition occurs in channelized or locally erosional environments including fluvial and submarine-channel deposits, barred beaches, and transgressive coastlines. the model considers both lateral and vertical migration of a scour surface and its associated depositional products. As in studies of bed-form climb, they recognize subcritical, critical, and supercritical climb of scour surfaces relative to adjacent depositional forms. 12 figures.

  15. Developing Terrestrial Trophic Models for Petroleum and Natural Gas Exploration and Production Sites: The Oklahoma Tallgrass Prairie Preserve Example

    SciTech Connect

    Stevenson, M; Coty, J; Stewart, J; Carlsen, T; Callaham, M

    2001-01-26

    This document details procedures to be used when constructing a conceptual terrestrial trophic model for natural gas and oil exploration and production sites. A site conceptual trophic model is intended for use in evaluating ecological impacts of oil and brine releases at E&P sites from a landscape or ecosystem perspective. The terrestrial trophic model protocol was developed using an example site, the Tallgrass Prairie Preserve (TPP) in Oklahoma. The procedure focuses on developing a terrestrial trophic model using information found in the primary literature, and augmented using site-specific research where available. Although the TPP has been the subject of considerable research and public interest since the high-profile reintroduction of bison (Bison bison) in 1993, little formal work has been done to develop a food web for the plant and animal communities found at the preserve. We describe how to divide species into guilds using explicit criteria on the basis of resource use and spatial distribution. For the TPP, sixteen guilds were developed for use in the trophic model, and the relationships among these guilds were analyzed. A brief discussion of the results of this model is provided, along with considerations for its use and areas for further study.

  16. An in vivo autotransplant model of renal preservation: cold storage versus machine perfusion in the prevention of ischemia/reperfusion injury.

    PubMed

    La Manna, Gaetano; Conte, Diletta; Cappuccilli, Maria Laura; Nardo, Bruno; D'Addio, Francesca; Puviani, Lorenza; Comai, Giorgia; Bianchi, Francesca; Bertelli, Riccardo; Lanci, Nicole; Donati, Gabriele; Scolari, Maria Piera; Faenza, Alessandro; Stefoni, Sergio

    2009-07-01

    There is increasing proof that organ preservation by machine perfusion is able to limit ischemia/reperfusion injury in kidney transplantation. This study was designed to compare the efficiency in hypothermic organ preservation by machine perfusion or cold storage in an animal model of kidney autotransplantation. Twelve pigs underwent left nephrectomy after warm ischemic time; the organs were preserved in machine perfusion (n = 6) or cold storage (n = 6) and then autotransplanted with immediate contralateral nephrectomy. The following parameters were compared between the two groups of animals: hematological and urine indexes of renal function, blood/gas analysis values, histological features, tissue adenosine-5'-triphosphate (ATP) content, perforin gene expression in kidney biopsies, and organ weight changes were compared before and after preservation. The amount of cellular ATP was significantly higher in organs preserved by machine perfusion; moreover, the study of apoptosis induction revealed an enhanced perforin expression in the kidneys, which underwent simple hypothermic preservation compared to the machine-preserved ones. Organ weight was significantly decreased after cold storage, but it remained quite stable for machine-perfused kidneys. The present model seems to suggest that organ preservation by hypothermic machine perfusion is able to better control cellular impairment in comparison with cold storage. PMID:19566736

  17. Acute inhibition of myostatin-family proteins preserves skeletal muscle in mouse models of cancer cachexia

    SciTech Connect

    Benny Klimek, Margaret E.; Aydogdu, Tufan; Link, Majik J.; Pons, Marianne; Koniaris, Leonidas G.; Zimmers, Teresa A.

    2010-01-15

    Cachexia, progressive loss of fat and muscle mass despite adequate nutrition, is a devastating complication of cancer associated with poor quality of life and increased mortality. Myostatin is a potent tonic muscle growth inhibitor. We tested how myostatin inhibition might influence cancer cachexia using genetic and pharmacological approaches. First, hypermuscular myostatin null mice were injected with Lewis lung carcinoma or B16F10 melanoma cells. Myostatin null mice were more sensitive to tumor-induced cachexia, losing more absolute mass and proportionately more muscle mass than wild-type mice. Because myostatin null mice lack expression from development, however, we also sought to manipulate myostatin acutely. The histone deacetylase inhibitor Trichostatin A has been shown to increase muscle mass in normal and dystrophic mice by inducing the myostatin inhibitor, follistatin. Although Trichostatin A administration induced muscle growth in normal mice, it failed to preserve muscle in colon-26 cancer cachexia. Finally we sought to inhibit myostatin and related ligands by administration of the Activin receptor extracellular domain/Fc fusion protein, ACVR2B-Fc. Systemic administration of ACVR2B-Fc potently inhibited muscle wasting and protected adipose stores in both colon-26 and Lewis lung carcinoma cachexia, without affecting tumor growth. Enhanced cachexia in myostatin knockouts indicates that host-derived myostatin is not the sole mediator of muscle wasting in cancer. More importantly, skeletal muscle preservation with ACVR2B-Fc establishes that targeting myostatin-family ligands using ACVR2B-Fc or related molecules is an important and potent therapeutic avenue in cancer cachexia.

  18. Acute inhibition of myostatin-family proteins preserves skeletal muscle in mouse models of cancer cachexia.

    PubMed

    Benny Klimek, Margaret E; Aydogdu, Tufan; Link, Majik J; Pons, Marianne; Koniaris, Leonidas G; Zimmers, Teresa A

    2010-01-15

    Cachexia, progressive loss of fat and muscle mass despite adequate nutrition, is a devastating complication of cancer associated with poor quality of life and increased mortality. Myostatin is a potent tonic muscle growth inhibitor. We tested how myostatin inhibition might influence cancer cachexia using genetic and pharmacological approaches. First, hypermuscular myostatin null mice were injected with Lewis lung carcinoma or B16F10 melanoma cells. Myostatin null mice were more sensitive to tumor-induced cachexia, losing more absolute mass and proportionately more muscle mass than wild-type mice. Because myostatin null mice lack expression from development, however, we also sought to manipulate myostatin acutely. The histone deacetylase inhibitor Trichostatin A has been shown to increase muscle mass in normal and dystrophic mice by inducing the myostatin inhibitor, follistatin. Although Trichostatin A administration induced muscle growth in normal mice, it failed to preserve muscle in colon-26 cancer cachexia. Finally we sought to inhibit myostatin and related ligands by administration of the Activin receptor extracellular domain/Fc fusion protein, ACVR2B-Fc. Systemic administration of ACVR2B-Fc potently inhibited muscle wasting and protected adipose stores in both colon-26 and Lewis lung carcinoma cachexia, without affecting tumor growth. Enhanced cachexia in myostatin knockouts indicates that host-derived myostatin is not the sole mediator of muscle wasting in cancer. More importantly, skeletal muscle preservation with ACVR2B-Fc establishes that targeting myostatin-family ligands using ACVR2B-Fc or related molecules is an important and potent therapeutic avenue in cancer cachexia. PMID:20036643

  19. A copula-based assessment of Bartlett-Lewis type of rainfall models for preserving drought statistics

    NASA Astrophysics Data System (ADS)

    Pham, M. T.; Vanhaute, W. J.; Vandenberghe, S.; De Baets, B.; Verhoest, N. E. C.

    2013-06-01

    Of all natural disasters, the economic and environmental consequences of droughts are among the highest because of their longevity and widespread spatial extent. Because of their extreme behaviour, studying droughts generally requires long time series of historical climate data. Rainfall is a very important variable for calculating drought statistics, for quantifying historical droughts or for assessing the impact on other hydrological (e.g. water stage in rivers) or agricultural (e.g. irrigation requirements) variables. Unfortunately, time series of historical observations are often too short for such assessments. To circumvent this, one may rely on the synthetic rainfall time series from stochastic point process rainfall models, such as Bartlett-Lewis models. The present study investigates whether drought statistics are preserved when simulating rainfall with Bartlett-Lewis models. Therefore, a 105 yr 10 min rainfall time series obtained at Uccle, Belgium is used as test case. First, drought events were identified on the basis of the Effective Drought Index (EDI), and each event was characterized by two variables, i.e. drought duration (D) and drought severity (S). As both parameters are interdependent, a multivariate distribution function, which makes use of a copula, was fitted. Based on the copula, four types of drought return periods are calculated for observed as well as simulated droughts and are used to evaluate the ability of the rainfall models to simulate drought events with the appropriate characteristics. Overall, all Bartlett-Lewis type of models studied fail in preserving extreme drought statistics, which is attributed to the model structure and to the model stationarity caused by maintaining the same parameter set during the whole simulation period.

  20. Preservation Matters

    ERIC Educational Resources Information Center

    Noriega, Chon A.

    2005-01-01

    One must undertake multi-institutional efforts that include universities, archives, museums, libraries and community-based arts organizations and the artists to preserve Latino art history. Arts infrastructure can be strengthened by various Chicano Studies Research Center projects that are concerned with archive building and scholarship, and with…

  1. Digital Preservation.

    ERIC Educational Resources Information Center

    Yakel, Elizabeth

    2001-01-01

    Reviews research on digital preservation issues, including born-digital and digitally recreated documents. Discusses electronic records research; metadata and other standards; electronic mail; Web-based documents; moving images media; selection of materials for digitization, including primary sources; administrative issues; media stability…

  2. Preserving Charge and Oxidation State of Au(III) Ions in an Agent-Functionalized Nanocrystal Model System

    PubMed Central

    2011-01-01

    Supporting functional molecules on crystal facets is an established technique in nanotechnology. To preserve the original activity of ionic metallorganic agents on a supporting template, conservation of the charge and oxidation state of the active center is indispensable. We present a model system of a metallorganic agent that, indeed, fulfills this design criterion on a technologically relevant metal support with potential impact on Au(III)-porphyrin-functionalized nanoparticles for an improved anticancer-drug delivery. Employing scanning tunneling microscopy and -spectroscopy in combination with photoemission spectroscopy, we clarify at the single-molecule level the underlying mechanisms of this exceptional adsorption mode. It is based on the balance between a high-energy oxidation state and an electrostatic screening-response of the surface (image charge). Modeling with first principles methods reveals submolecular details of the metal–ligand bonding interaction and completes the study by providing an illustrative electrostatic model relevant for ionic metalorganic agent molecules, in general. PMID:21736315

  3. Preserved Tool Knowledge in the Context of Impaired Action Knowledge: Implications for Models of Semantic Memory

    PubMed Central

    Garcea, Frank E.; Dombovy, Mary; Mahon, Bradford Z.

    2013-01-01

    A number of studies have observed that the motor system is activated when processing the semantics of manipulable objects. Such phenomena have been taken as evidence that simulation over motor representations is a necessary and intermediary step in the process of conceptual understanding. Cognitive neuropsychological evaluations of patients with impairments for action knowledge permit a direct test of the necessity of motor simulation in conceptual processing. Here, we report the performance of a 47-year-old male individual (Case AA) and six age-matched control participants on a number of tests probing action and object knowledge. Case AA had a large left-hemisphere frontal-parietal lesion and hemiplegia affecting his right arm and leg. Case AA presented with impairments for object-associated action production, and his conceptual knowledge of actions was severely impaired. In contrast, his knowledge of objects such as tools and other manipulable objects was largely preserved. The dissociation between action and object knowledge is difficult to reconcile with strong forms of the embodied cognition hypothesis. We suggest that these, and other similar findings, point to the need to develop tractable hypotheses about the dynamics of information exchange among sensory, motor and conceptual processes. PMID:23641205

  4. An Empirical Analysis of Citizens' Acceptance Decisions of Electronic-Government Services: A Modification of the Unified Theory of Acceptance and Use of Technology (UTAUT) Model to Include Trust as a Basis for Investigation

    ERIC Educational Resources Information Center

    Awuah, Lawrence J.

    2012-01-01

    Understanding citizens' adoption of electronic-government (e-government) is an important topic, as the use of e-government has become an integral part of governance. Success of such initiatives depends largely on the efficient use of e-government services. The unified theory of acceptance and use of technology (UTAUT) model has provided a…

  5. Acceptability of the Nestorone®/Ethinyl Estradiol Contraceptive Vaginal Ring: Development of a Model; Implications for Introduction

    PubMed Central

    Merkatz, Ruth B.; Plagianos, Marlena; Hoskin, Elena; Cooney, Michael; Hewett, Paul C; Mensch, Barbara S.

    2015-01-01

    Objectives Develop and test a theoretical acceptability model for the Nestorone®/ethinyl estradiol (NES/EE) contraceptive vaginal ring (CVR); explore whether domains of use within the model predict satisfaction, method adherence and CVR continuation. Study Design Four domains of use were considered relative to outcome markers of acceptability, i.e. method satisfaction, adherence, and continuation. A questionnaire to evaluate subjects’ experiences relative to the domains, their satisfaction (Likert scale), and adherence to instructions for use was developed and administered to 1036 women enrolled in a 13-cycle Phase 3 trial. Method continuation was documented from the trial database. Stepwise logistic regression (LR) analysis was conducted and odds ratios calculated to assess associations of satisfaction with questions from the 4 domains. Fisher’s exact test was used to determine the association of satisfaction with outcome measures. Results A final acceptability model was developed based on the following determinants of CVR satisfaction: ease of use, side effects, expulsions/feeling the CVR, and sexual activity including physical effects during intercourse. Satisfaction was high (89%) and related to higher method adherence [OR 2.6(1.3,5.2)] and continuation [OR5.5(3.5, 8.4)]. According to the LR analysis, attributes of CVR use representing items from the 4 domains — finding it easy to remove, not complaining of side effects, not feeling the CVR while wearing it, and experiencing no change or an increase in sexual pleasure and/or frequency — were associated with higher odds of satisfaction. Conclusion Hypothesized domains of CVR use were related to satisfaction, which was associated with adherence and continuation. Results provide a scientific basis for introduction and future research. PMID:24993487

  6. Mesenchymal Stem Cells Preserve Working Memory in the 3xTg-AD Mouse Model of Alzheimer’s Disease

    PubMed Central

    Ruzicka, Jiri; Kulijewicz-Nawrot, Magdalena; Rodrigez-Arellano, Jose Julio; Jendelova, Pavla; Sykova, Eva

    2016-01-01

    The transplantation of stem cells may have a therapeutic effect on the pathogenesis and progression of neurodegenerative disorders. In the present study, we transplanted human mesenchymal stem cells (MSCs) into the lateral ventricle of a triple transgenic mouse model of Alzheimer´s disease (3xTg-AD) at the age of eight months. We evaluated spatial reference and working memory after MSC treatment and the possible underlying mechanisms, such as the influence of transplanted MSCs on neurogenesis in the subventricular zone (SVZ) and the expression levels of a 56 kDa oligomer of amyloid β (Aβ*56), glutamine synthetase (GS) and glutamate transporters (Glutamate aspartate transporter (GLAST) and Glutamate transporter-1 (GLT-1)) in the entorhinal and prefrontal cortices and the hippocampus. At 14 months of age we observed the preservation of working memory in MSC-treated 3xTg-AD mice, suggesting that such preservation might be due to the protective effect of MSCs on GS levels and the considerable downregulation of Aβ*56 levels in the entorhinal cortex. These changes were observed six months after transplantation, accompanied by clusters of proliferating cells in the SVZ. Since the grafted cells did not survive for the whole experimental period, it is likely that the observed effects could have been transiently more pronounced at earlier time points than at six months after cell application. PMID:26821012

  7. Using Medical History Embedded in Biometrics Medical Card for User Identity Authentication: Privacy Preserving Authentication Model by Features Matching

    PubMed Central

    Fong, Simon; Zhuang, Yan

    2012-01-01

    Many forms of biometrics have been proposed and studied for biometrics authentication. Recently researchers are looking into longitudinal pattern matching that based on more than just a singular biometrics; data from user's activities are used to characterise the identity of a user. In this paper we advocate a novel type of authentication by using a user's medical history which can be electronically stored in a biometric security card. This is a sequel paper from our previous work about defining abstract format of medical data to be queried and tested upon authentication. The challenge to overcome is preserving the user's privacy by choosing only the useful features from the medical data for use in authentication. The features should contain less sensitive elements and they are implicitly related to the target illness. Therefore exchanging questions and answers about a few carefully chosen features in an open channel would not easily or directly expose the illness, but yet it can verify by inference whether the user has a record of it stored in his smart card. The design of a privacy preserving model by backward inference is introduced in this paper. Some live medical data are used in experiments for validation and demonstration. PMID:22550398

  8. Mesenchymal Stem Cells Preserve Working Memory in the 3xTg-AD Mouse Model of Alzheimer's Disease.

    PubMed

    Ruzicka, Jiri; Kulijewicz-Nawrot, Magdalena; Rodrigez-Arellano, Jose Julio; Jendelova, Pavla; Sykova, Eva

    2016-01-01

    The transplantation of stem cells may have a therapeutic effect on the pathogenesis and progression of neurodegenerative disorders. In the present study, we transplanted human mesenchymal stem cells (MSCs) into the lateral ventricle of a triple transgenic mouse model of Alzheimer's disease (3xTg-AD) at the age of eight months. We evaluated spatial reference and working memory after MSC treatment and the possible underlying mechanisms, such as the influence of transplanted MSCs on neurogenesis in the subventricular zone (SVZ) and the expression levels of a 56 kDa oligomer of amyloid β (Aβ*56), glutamine synthetase (GS) and glutamate transporters (Glutamate aspartate transporter (GLAST) and Glutamate transporter-1 (GLT-1)) in the entorhinal and prefrontal cortices and the hippocampus. At 14 months of age we observed the preservation of working memory in MSC-treated 3xTg-AD mice, suggesting that such preservation might be due to the protective effect of MSCs on GS levels and the considerable downregulation of Aβ*56 levels in the entorhinal cortex. These changes were observed six months after transplantation, accompanied by clusters of proliferating cells in the SVZ. Since the grafted cells did not survive for the whole experimental period, it is likely that the observed effects could have been transiently more pronounced at earlier time points than at six months after cell application. PMID:26821012

  9. From Darwin to Mars: desert varnish as a model for preservation of complex (bio)chemical systems

    NASA Astrophysics Data System (ADS)

    Perry, Randall S.; Kolb, Vera M.

    2004-02-01

    The search for life on Mars is an important goal of NASA and other space agencies. It is not known if chemical evolution on Mars produced the same or similar types of life as on Earth. If not, what would non-Earth biosignatures look like? If life has left its footprint on Mars, what chemical signatures can we recognize, and how can we prevent missing novel life signatures? Alternatively, chemical evolution on Mars may have produced complex chemical systems, which, however, did not lead to life. How can such systems be identified? We use as a model a complex inorganic-organic-biotic system on Earth, commonly called desert or rock varnish, which has been known to Darwin, and which is now also indicated on Mars. We describe unique complex chemical markers that are preserved in rock varnish on Earth. An intricate interaction between minerals, metals, and organic compounds is responsible for their preservation. We suggest some important types of organic compounds to look for in the Martian varnish, should it exist.

  10. Activation of the molecular chaperone, sigma 1 receptor, preserves cone function in a murine model of inherited retinal degeneration.

    PubMed

    Wang, Jing; Saul, Alan; Roon, Penny; Smith, Sylvia B

    2016-06-28

    Retinal degenerative diseases are major causes of untreatable blindness, and novel approaches to treatment are being sought actively. Here we explored the activation of a unique protein, sigma 1 receptor (Sig1R), in the treatment of PRC loss because of its multifaceted role in cellular survival. We used Pde6β(rd10) (rd10) mice, which harbor a mutation in the rod-specific phosphodiesterase gene Pde6β and lose rod and cone photoreceptor cells (PRC) within the first 6 wk of life, as a model for severe retinal degeneration. Systemic administration of the high-affinity Sig1R ligand (+)-pentazocine [(+)-PTZ] to rd10 mice over several weeks led to the rescue of cone function as indicated by electroretinographic recordings using natural noise stimuli and preservation of cone cells upon spectral domain optical coherence tomography and retinal histological examination. The protective effect appears to result from the activation of Sig1R, because rd10/Sig1R(-/-) mice administered (+)-PTZ exhibited no cone preservation. (+)-PTZ treatment was associated with several beneficial cellular phenomena including attenuated reactive gliosis, reduced microglial activation, and decreased oxidative stress in mutant retinas. To our knowledge, this is the first report that activation of Sig1R attenuates inherited PRC loss. The findings may have far-reaching therapeutic implications for retinal neurodegenerative diseases. PMID:27298364

  11. Using medical history embedded in biometrics medical card for user identity authentication: privacy preserving authentication model by features matching.

    PubMed

    Fong, Simon; Zhuang, Yan

    2012-01-01

    Many forms of biometrics have been proposed and studied for biometrics authentication. Recently researchers are looking into longitudinal pattern matching that based on more than just a singular biometrics; data from user's activities are used to characterise the identity of a user. In this paper we advocate a novel type of authentication by using a user's medical history which can be electronically stored in a biometric security card. This is a sequel paper from our previous work about defining abstract format of medical data to be queried and tested upon authentication. The challenge to overcome is preserving the user's privacy by choosing only the useful features from the medical data for use in authentication. The features should contain less sensitive elements and they are implicitly related to the target illness. Therefore exchanging questions and answers about a few carefully chosen features in an open channel would not easily or directly expose the illness, but yet it can verify by inference whether the user has a record of it stored in his smart card. The design of a privacy preserving model by backward inference is introduced in this paper. Some live medical data are used in experiments for validation and demonstration. PMID:22550398

  12. 57Fe Mössbauer spectroscopy used to develop understanding of a diamond preservation index model

    NASA Astrophysics Data System (ADS)

    Yambissa, M. T.; Forder, S. D.; Bingham, P. A.

    2016-12-01

    57Fe Mössbauer spectroscopy has provided precise and accurate iron redox ratios Fe2+/Fe3+ in ilmenite, FeTiO3, found within kimberlite samples from the Catoca and Camatxia kimberlite pipes from N.E. Angola. Ilmenite is one of the key indicator minerals for diamond survival and it is also one of the iron-bearing minerals with iron naturally occurring in one or both of the oxidation states Fe3+ and Fe2+. For this reason it is a good indicator for studying oxygen fugacities ( fO2) in mineral samples, which can then be related to iron redox ratios, Fe2+/Fe3+. In this paper we demonstrate that the oxidation state of the ilmenite mineral inclusion from sampled kimberlite rock is a key indicator of the oxidation state of the host kimberlite assemblage, which in turn determines the genesis of diamond, grade variation and diamond quality. Ilmenite samples from the two different diamondiferous kimberlite localities (Catoca and Camatxia) in the Lucapa graben, N.E. Angola, were studied using Mössbauer spectroscopy and X-Ray Diffractometry, in order to infer the oxidation state of their source regions in the mantle, oxygen partial pressure and diamond preservation conditions. The iron redox ratios, obtained using Mössbauer spectroscopy, show that the Catoca diamond kimberlite is more oxidised than kimberlite found in the Camatxia pipe, which is associated within the same geological tectonic structure. Here we demonstrate that57Fe Mössbauer spectroscopy can assist geologists and mining engineers to effectively evaluate and determine whether kimberlite deposits are economically feasible for diamond mining.

  13. Preserving the Public Good: Presenting an Organizational Model for the Changing Future of Higher Education

    ERIC Educational Resources Information Center

    Garcia, Stephanie Parra

    2011-01-01

    Institutions of higher education face financial pressure to become self-sustaining (Gumport, 2001; 2000). This rapidly growing economic demand is negatively affecting the social mission of higher education (Kezar, 2004). Scholars suggest the implementation of a new model of higher education, one that blends a for-profit model with the traditional…

  14. On the asymptotic preserving property of the unified gas kinetic scheme for the diffusion limit of linear kinetic models

    SciTech Connect

    Mieussens, Luc

    2013-11-15

    The unified gas kinetic scheme (UGKS) of K. Xu et al. (2010) [37], originally developed for multiscale gas dynamics problems, is applied in this paper to a linear kinetic model of radiative transfer theory. While such problems exhibit purely diffusive behavior in the optically thick (or small Knudsen) regime, we prove that UGKS is still asymptotic preserving (AP) in this regime, but for the free transport regime as well. Moreover, this scheme is modified to include a time implicit discretization of the limit diffusion equation, and to correctly capture the solution in case of boundary layers. Contrary to many AP schemes, this method is based on a standard finite volume approach, it does neither use any decomposition of the solution, nor staggered grids. Several numerical tests demonstrate the properties of the scheme.

  15. Numerical Study of Cell Cryo-Preservation: A Network Model of Intracellular Ice Formation

    PubMed Central

    Li, Wei; Yang, Geer; Zhang, Aili; Xu, Lisa X.

    2013-01-01

    In this study, a new intracellular ice formation network model, coupled with an improved cell dehydration model has been developed. The non-uniform dehydration of the cell during freezing is simulated with moving boundary condition. Internal cell structures like cell nucleus are taken into consideration. The IIF network model is developed from classic diffusion limited IIF model in order to simulate spatial ice growth pattern inside cells. Simulation results suggest that cell nuclear plays a significant role in cryo-dehydration and would affect water/CPA concentration gradient inside the cell. At the same time, the ice growth pattern of exogenous IIF hypothesis is examined in the model. It is consistent with our previous experiments, in which we witnessed the intracellular ice first grown into the nucleus before spreading to the whole intercellular space. According to this model, the water concentration difference between nucleus and cytoplasm during cryo-dehydration could partly explain why ice crystal in the nucleus grows faster. However, it is not the dominate factor. Higher diffusion coefficient in cell nucleus might play a more important role in the phenomenon. PMID:23526979

  16. Improving Technology Acceptance Modeling for Disadvantaged Communities Using a Systems Engineering Approach

    ERIC Educational Resources Information Center

    Fletcher, Jordan L.

    2013-01-01

    Developing nations are poised to spend billions on information and communication technology (ICT) innovation in 2020. A study of the historical adoption of ICT in developing nations has indicated that their adoption patterns do not follow typical technology innovation adoption models. This study addressed the weaknesses found in existing…

  17. Generation of connectivity-preserving surface models of multiple sclerosis lesions.

    PubMed

    Meruvia-Pastor, Oscar; Xiao, Mei; Soh, Jung; Sensen, Christoph W

    2011-01-01

    Progression of multiple sclerosis (MS) results in brain lesions caused by white matter inflammation. MS lesions have various shapes, sizes and locations, affecting cognitive abilities of patients to different extents. To facilitate the visualization of the brain lesion distribution, we have developed a software tool to build 3D surface models of MS lesions. This tool allows users to create 3D models of lesions quickly and to visualize the lesions and brain tissues using various visual attributes and configurations. The software package is based on breadth-first search based 3D connected component analysis and a 3D flood-fill based region growing algorithm to generate 3D models from binary or non-binary segmented medical image stacks. PMID:21335819

  18. Three-Dimensional Model for Preservation and Restoration of Architectural Heritage

    NASA Technical Reports Server (NTRS)

    Marchis, Elena

    2011-01-01

    Thc aim of the research will be to create a model, three-dimensional mathematical. implementation. consultation and assistance to "large" restoration projects that will assist the structural analysis, allowing easier display of dynamic strain. analysis and lighting noise. It could also be a valuable tool for decision support. therefore. may simulate several possible scenarios for intervention, This model appears therefore an excellent support for recovering. ordering and monitoring information about materials and data (stage of restoration. photographs. sampling points. results of diagnostic tests, etc.) collected dynamically during the "life" of the cultural heritage. allowing to document its complete history

  19. Parental modelling and prompting effects on acceptance of a novel fruit in 2-4-year-old children are dependent on children's food responsiveness.

    PubMed

    Blissett, Jackie; Bennett, Carmel; Fogel, Anna; Harris, Gillian; Higgs, Suzanne

    2016-02-14

    Few children consume the recommended portions of fruit or vegetables. This study examined the effects of parental physical prompting and parental modelling in children's acceptance of a novel fruit (NF) and examined the role of children's food-approach and food-avoidance traits on NF engagement and consumption. A total of 120 caregiver-child dyads (fifty-four girls, sixty-six boys) participated in this study. Dyads were allocated to one of the following three conditions: physical prompting but no modelling, physical prompting and modelling or a modelling only control condition. Dyads ate a standardised meal containing a portion of a fruit new to the child. Parents completed measures of children's food approach and avoidance. Willingness to try the NF was observed, and the amount of the NF consumed was measured. Physical prompting but no modelling resulted in greater physical refusal of the NF. There were main effects of enjoyment of food and food fussiness on acceptance. Food responsiveness interacted with condition such that children who were more food responsive had greater NF acceptance in the prompting and modelling conditions in comparison with the modelling only condition. In contrast, children with low food responsiveness had greater acceptance in the modelling control condition than in the prompting but no modelling condition. Physical prompting in the absence of modelling is likely to be detrimental to NF acceptance. Parental use of physical prompting strategies, in combination with modelling of NF intake, may facilitate acceptance of NF, but only in food-responsive children. Modelling consumption best promotes acceptance in children with low food responsiveness. PMID:26603382

  20. Preserving Heterogeneity and Consistency in Hydrological Model Inversions by Adjusting Pedotransfer Functions

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Numerical modeling is the dominant method for quantifying water flow and the transport of dissolved constituents in surface soils as well as the deeper vadose zone. While the fundamental laws that govern the mechanics of the flow processes in terms of Richards' and convection-dispersion equations a...

  1. Structure-preserving model reduction for spatially interconnected systems with experimental validation on an actuated beam

    NASA Astrophysics Data System (ADS)

    Al-Taie, Fatimah; Werner, Herbert

    2016-06-01

    A technique for model reduction of exponentially stable spatially interconnected systems is presented, where the order of the reduced model is determined by the number of truncated small generalised singular values of the structured solutions to a pair of Lyapunov inequalities. For parameter-invariant spatially interconnected systems, the technique is based on solving a pair of Lyapunov inequalities in continuous-time and -space domain with a rank constraint. Using log-det and cone complementarity methods, an improved error bound can be obtained. The approach is extended to spatially parameter-varying systems, and a balanced truncation approach using parameter-dependent Gramians is proposed to reduce the conservatism caused by the use of constant Gramians. This is done by considering two important operators, which can be used to represent multidimensional systems (temporal- and spatial-linear parameter varying interconnected systems). The results are illustrated with their application to an experimentally identified spatially interconnected model of an actuated beam; the experimentally obtained response to an excitation signal is compared with the response predicted by a reduced model.

  2. Regulatory acceptance and use of 3R models for pharmaceuticals and chemicals: expert opinions on the state of affairs and the way forward.

    PubMed

    Schiffelers, Marie-Jeanne W A; Blaauboer, Bas J; Bakker, Wieger E; Beken, Sonja; Hendriksen, Coenraad F M; Koëter, Herman B W M; Krul, Cyrille

    2014-06-01

    Pharmaceuticals and chemicals are subjected to regulatory safety testing accounting for approximately 25% of laboratory animal use in Europe. This testing meets various objections and has led to the development of a range of 3R models to Replace, Reduce or Refine the animal models. However, these models must overcome many barriers before being accepted for regulatory risk management purposes. This paper describes the barriers and drivers and options to optimize this acceptance process as identified by two expert panels, one on pharmaceuticals and one on chemicals. To untangle the complex acceptance process, the multilevel perspective on technology transitions is applied. This perspective defines influences at the micro-, meso- and macro level which need alignment to induce regulatory acceptance of a 3R model. This paper displays that there are many similar mechanisms within both sectors that prevent 3R models from becoming accepted for regulatory risk assessment and management. Shared barriers include the uncertainty about the value of the new 3R models (micro level), the lack of harmonization of regulatory requirements and acceptance criteria (meso level) and the high levels of risk aversion (macro level). In optimizing the process commitment, communication, cooperation and coordination are identified as critical drivers. PMID:24534000

  3. Exercise motives and positive body image in physically active college women and men: Exploring an expanded acceptance model of intuitive eating.

    PubMed

    Tylka, Tracy L; Homan, Kristin J

    2015-09-01

    The acceptance model of intuitive eating posits that body acceptance by others facilitates body appreciation and internal body orientation, which contribute to intuitive eating. Two domains of exercise motives (functional and appearance) may also be linked to these variables, and thus were integrated into the model. The model fit the data well for 406 physically active U.S. college students, although some pathways were stronger for women. Body acceptance by others directly contributed to higher functional exercise motives and indirectly contributed to lower appearance exercise motives through higher internal body orientation. Functional exercise motives positively, and appearance exercise motives inversely, contributed to body appreciation. Whereas body appreciation positively, and appearance exercise motives inversely, contributed to intuitive eating for women, only the latter association was evident for men. To benefit positive body image and intuitive eating, efforts should encourage body acceptance by others and emphasize functional and de-emphasize appearance exercise motives. PMID:26281958

  4. Parametric Accuracy: Building Information Modeling Process Applied to the Cultural Heritage Preservation

    NASA Astrophysics Data System (ADS)

    Garagnani, S.; Manferdini, A. M.

    2013-02-01

    Since their introduction, modeling tools aimed to architectural design evolved in today's "digital multi-purpose drawing boards" based on enhanced parametric elements able to originate whole buildings within virtual environments. Semantic splitting and elements topology are features that allow objects to be "intelligent" (i.e. self-aware of what kind of element they are and with whom they can interact), representing this way basics of Building Information Modeling (BIM), a coordinated, consistent and always up to date workflow improved in order to reach higher quality, reliability and cost reductions all over the design process. Even if BIM was originally intended for new architectures, its attitude to store semantic inter-related information can be successfully applied to existing buildings as well, especially if they deserve particular care such as Cultural Heritage sites. BIM engines can easily manage simple parametric geometries, collapsing them to standard primitives connected through hierarchical relationships: however, when components are generated by existing morphologies, for example acquiring point clouds by digital photogrammetry or laser scanning equipment, complex abstractions have to be introduced while remodeling elements by hand, since automatic feature extraction in available software is still not effective. In order to introduce a methodology destined to process point cloud data in a BIM environment with high accuracy, this paper describes some experiences on monumental sites documentation, generated through a plug-in written for Autodesk Revit and codenamed GreenSpider after its capability to layout points in space as if they were nodes of an ideal cobweb.

  5. Data Preservation and Curation for the Planetary Science Community

    NASA Astrophysics Data System (ADS)

    Hughes, J. S.; Crichton, D. J.; Joyner, R.; Hardman, S.; Rye, E.

    2013-12-01

    The Planetary Data System (PDS) has just released PDS4 Version 1.0, its next generation data standards for the planetary science archive. These data standards are the result of a multi-year effort to develop an information model based on accepted standards for data preservation, data curation, metadata management, and model development. The resulting information model is subsequently used to drive information system development from the generation of data standards documentation to the configuration of federated registries and search engines. This paper will provide an overview of the development of the PDS4 Information Model and focus on the application of the Open Archive Information System (OAIS) Reference Model - ISO 14721:2003, the Metadata Registry (MDR) Standard - ISO/IEC 11179, and the E-Business XML Standard to help ensure the long-term preservation and curation of planetary science data. Copyright 2013 California Institute of Technology Government sponsorship acknowledged

  6. Modeling, Analysis, and Preservation Techniques for Historic Reinforced Concrete Structures in Seismic Prone Regions Case Study: Augusta Airship Hangar, Sicily

    SciTech Connect

    Cronin, Kelly; Whyte, Catherine; Reiner, Tom

    2008-07-08

    Throughout the world there are hundreds of historic monuments and structures considered to be invaluable and irreplaceable. They are symbols of cultural identity and a means of educating people about history. Preservation of historic monuments and structures is therefore an important part of safeguarding these cultural heritage sites so that they retain their value for future generations.This report discusses a procedure for the investigation of seismic hazards in existing buildings and possible steps that can be taken to avoid damage caused by these hazards. The Augusta Airship Hangar located in Sicily, will be used as a case study however the topics addressed in this paper can be applied to other structures of historic value around the world.First state-of-the-art scanning procedures were used to create scale digital models that were imported into a structural analysis program. Within this program dynamic analyses were performed on the model based on actual ground motions taken close to the site. This data was used to determine the period and mode shapes of the structure. Then a nonlinear analysis, including a static pushover analysis, was implemented on a two-dimensional model of the structural frame. From this analysis the failure mechanisms of the structure were revealed with relation to an allowable roof displacement. The structural integrity of the structure was evaluated based on pre-defined performance goals. Finally multiple suggestions were made how the Augusta Airship Hangar might be repaired and strengthened so that this structure will not be destroyed should an earthquake occur.The results of our study show that historic structures, despite their age, can still be strong and ductile. Also there are a multitude of effective preservation and retrofit techniques that can be used to strengthen these historic structures, should an earthquake occur. Through this study, the Augusta Airship Hangar has proven to be not only a historic symbol for Sicily but

  7. Modeling, Analysis, and Preservation Techniques for Historic Reinforced Concrete Structures in Seismic Prone Regions Case Study: Augusta Airship Hangar, Sicily

    NASA Astrophysics Data System (ADS)

    Cronin, Kelly; Reiner, Tom; Whyte, Catherine

    2008-07-01

    Throughout the world there are hundreds of historic monuments and structures considered to be invaluable and irreplaceable. They are symbols of cultural identity and a means of educating people about history. Preservation of historic monuments and structures is therefore an important part of safeguarding these cultural heritage sites so that they retain their value for future generations. This report discusses a procedure for the investigation of seismic hazards in existing buildings and possible steps that can be taken to avoid damage caused by these hazards. The Augusta Airship Hangar located in Sicily, will be used as a case study however the topics addressed in this paper can be applied to other structures of historic value around the world. First state-of-the-art scanning procedures were used to create scale digital models that were imported into a structural analysis program. Within this program dynamic analyses were performed on the model based on actual ground motions taken close to the site. This data was used to determine the period and mode shapes of the structure. Then a nonlinear analysis, including a static pushover analysis, was implemented on a two-dimensional model of the structural frame. From this analysis the failure mechanisms of the structure were revealed with relation to an allowable roof displacement. The structural integrity of the structure was evaluated based on pre-defined performance goals. Finally multiple suggestions were made how the Augusta Airship Hangar might be repaired and strengthened so that this structure will not be destroyed should an earthquake occur. The results of our study show that historic structures, despite their age, can still be strong and ductile. Also there are a multitude of effective preservation and retrofit techniques that can be used to strengthen these historic structures, should an earthquake occur. Through this study, the Augusta Airship Hangar has proven to be not only a historic symbol for Sicily but

  8. Antimicrobial effect of natural preservatives in a cooked and acidified chicken meat model.

    PubMed

    Lemay, Marie-Josée; Choquette, Julie; Delaquis, Pascal J; Claude, Gariépy; Rodrigue, Natalie; Saucier, Linda

    2002-10-25

    The inhibitory effect of Microgard 100, Microgard 300, nisin, Alta 2002, Perlac 1902, sodium lactate and essential oil of mustard on microorganisms experimentally inoculated was screened in an acidified chicken meat model (pH = 5.0) and stored for 2 weeks at a none restrictive growth temperature of 22 degrees C. All antimicrobials tested were used at the highest concentration recommended by their manufacturer. Sausage batter made with mechanically deboned chicken was inoculated with a mixed culture of Escherichia coli ATCC 25922, Brochothrix thermosphacta CRDAV452, and a protective culture Lactobacillus alimentarius BJ33 (FloraCan L-2). A final cell concentration of 3-4 log CFU g (-1) was targeted after cooking at a core temperature of 55 degrees C for each microorganism in order to assess cell count variation effectively. Composition, water activity (a(w)), pH and redox potential of the sausage model was also evaluated. The E. coli population decreased steadily during storage and was close or below detection level (< 1 log CFU g (-1)) for all treatments, including the control, after 14 days. Sodium lactate was most effective against B. thermosphacta; population was 4 log lower than the control after 14 days of storage. When essential oil of mustard was used, aerobic mesophilic bacteria and lactic acid bacteria were significantly lower than the control after 2 days of storage (P < or = 0.05). The other antimicrobial agents tested had no significant effect on the aerobic mesophilic bacteria, E. coli, B. thermosphacta and lactic acid bacteria counts, when compared to the control. PMID:12227640

  9. 3D-manufactured patient-specific models of congenital heart defects for communication in clinical practice: feasibility and acceptability

    PubMed Central

    Biglino, Giovanni; Capelli, Claudio; Wray, Jo; Schievano, Silvia; Leaver, Lindsay-Kay; Khambadkone, Sachin; Giardini, Alessandro; Derrick, Graham; Jones, Alexander; Taylor, Andrew M

    2015-01-01

    Objectives To assess the communication potential of three-dimensional (3D) patient-specific models of congenital heart defects and their acceptability in clinical practice for cardiology consultations. Design This was a questionnaire-based study in which participants were randomised into two groups: the ‘model group’ received a 3D model of the cardiac lesion(s) being discussed during their appointment, while the ‘control group’ had a routine visit. Setting Outpatient clinic, cardiology follow-up visits. Participants 103 parents of children with congenital heart disease were recruited (parental age: 43±8 years; patient age: 12±6 years). In order to have a 3D model made, patients needed to have a recent cardiac MRI examination; this was the crucial inclusion criterion. Interventions Questionnaires were administered to the participants before and after the visits and an additional questionnaire was administered to the attending cardiologist. Main outcome measures Rating (1–10) for the liking of the 3D model, its usefulness and the clarity of the explanation received were recorded, as well as rating (1–10) of the parental understanding and their engagement according to the cardiologist. Furthermore, parental knowledge was assessed by asking them to mark diagrams, tick keywords and provide free text answers. The duration of consultations was recorded and parent feedback collected. Results Parents and cardiologists both found the models to be very useful and helpful in engaging the parents in discussing congenital heart defects. Parental knowledge was not associated with their level of education (p=0.2) and did not improve following their visit. Consultations involving 3D models lasted on average 5 min longer (p=0.02). Conclusions Patient-specific models can enhance engagement with parents and improve communication between cardiologists and parents, potentially impacting on parent and patient psychological adjustment following treatment. However, in

  10. Assessing in vivo fertilizing capacity of liquid-preserved boar semen according to the 'Hanover gilt model'.

    PubMed

    Ardón, F; Döhring, A; Le Thi, X; Weitze, K F; Waberski, D

    2003-04-01

    The goal of this study was to determine the ability of the Hanover gilt model to assess in vivo fertilizing capacity of preserved sperm and to consider whether any modifications to this model were needed. This model evaluates the fertilizing capacity of semen based on the fertilization rate, the rate of normal embryos and the accessory sperm count of 3-5-day embryos. Its distinguishing characteristics are the use of one-time insemination of sperm in reduced numbers, of spontaneously ovulating gilts and of ovulation detection through ultrasound examination of ovaries. Reduced sperm numbers allow for an accurate evaluation of the fertilizing potential of different semen treatments, thereby avoiding the compensatory effect of doses calibrated to maximize fertility. The model's usefulness was assessed in a trial run designed to compare the fertilizing capacity of liquid boar semen diluted into two different extenders. The diluent, the boar and the backflow, had no significant effect on any of the parameters studied. Gilts inseminated less than 24 h before ovulation had a significantly higher (p < 0.01) fertilization rate and accessory sperm cell count (p < 0.05) than those inseminated more than 24 h before ovulation. Very good/good embryos from homogeneous litters (only very good/good embryos were present) had a significantly higher (p < 0.01) accessory sperm count than those from heterogeneous litters (at least one embryo was of a different quality and/or oocytes were present). Both very good/good and degenerated/retarded embryos from heterogeneous litters had low accessory sperm numbers. This suggests that accessory sperm count is significantly related to the quality of the litter, but not to the quality of the embryo within gilts. It can be concluded that the Hanover gilt model is sensitive enough to show fertility differences (in this study, those associated with in vivo ageing of semen), while using relatively few gilts and little time. PMID:12654028

  11. Regulatory acceptance of animal models of disease to support clinical trials of medicines and advanced therapy medicinal products.

    PubMed

    Cavagnaro, Joy; Silva Lima, Beatriz

    2015-07-15

    The utility of animal models of disease for assessing the safety of novel therapeutic modalities has become an increasingly important topic of discussion as research and development efforts focus on improving the predictive value of animal studies to support accelerated clinical development. Medicines are approved for marketing based upon a determination that their benefits outweigh foreseeable risks in specific indications, specific populations, and at specific dosages and regimens. No medicine is 100% safe. A medicine is less safe if the actual risks are greater than the predicted risks. The purpose of preclinical safety assessment is to understand the potential risks to aid clinical decision-making. Ideally preclinical studies should identify potential adverse effects and design clinical studies that will minimize their occurrence. Most regulatory documents delineate the utilization of conventional "normal" animal species to evaluate the safety risk of new medicines (i.e., new chemical entities and new biological entities). Animal models of human disease are commonly utilized to gain insight into the pathogenesis of disease and to evaluate efficacy but less frequently utilized in preclinical safety assessment. An understanding of the limitations of the animal disease models together with a better understanding of the disease and how toxicity may be impacted by the disease condition should allow for a better prediction of risk in the intended patient population. Importantly, regulatory authorities are becoming more willing to accept and even recommend data from experimental animal disease models that combine efficacy and safety to support clinical development. PMID:25814257

  12. Triptolide Preserves Cognitive Function and Reduces Neuropathology in a Mouse Model of Alzheimer's Disease

    PubMed Central

    Cheng, Shaowu; LeBlanc, Kyle J.; Li, Ling

    2014-01-01

    Triptolide, a major bioactive ingredient of a widely used herbal medicine, has been shown to possess multiple pharmacological functions, including potential neuroprotective effects pertinent to Alzheimer's disease (AD) in vitro. However, the therapeutic potential of triptolide for AD in vivo has not been thoroughly evaluated. In the present study, we investigated the impact of peripherally administered triptolide on AD-related behavior and neuropathology in APPswe/PS1ΔE9 (APP/PS1) mice, an established model of AD. Our results showed that two-month treatment with triptolide rescued cognitive function in APP/PS1 mice. Immunohistochemical analyses indicated that triptolide treatment led to a significant decrease in amyloid-β (Aβ) deposition and neuroinflammation in treated mice. In contrast to previous findings in vitro, biochemical analyses showed that triptolide treatment did not significantly affect the production pathway of Aβ in vivo. Intriguingly, further analyses revealed that triptolide treatment upregulated the level of insulin-degrading enzyme, a major Aβ-degrading enzyme in the brain, indicating that triptolide treatment reduced Aβ pathology by enhancing the proteolytic degradation of Aβ. Our findings demonstrate that triptolide treatment ameliorates key behavioral and neuropathological changes found in AD, suggesting that triptolide may serve as a potential therapeutic agent for AD. PMID:25275487

  13. Abatacept Treatment Does Not Preserve Renal Function in the Streptozocin-Induced Model of Diabetic Nephropathy

    PubMed Central

    Helding Kvist, Peter; Douglas Galsgaard, Elisabeth; Coppieters, Ken

    2016-01-01

    Diabetic nephropathy (DN) is one of the most severe complications of diabetes and remains the largest cause of end-stage renal disease in the Western world. Treatment options are limited and novel therapies that effectively slow disease progression are warranted. Previous work suggested that treatment with CTLA4-Ig (abatacept), a molecule that binds and blocks B7-1 and is licensed for the treatment of rheumatoid arthritis, could ameliorate DN. This study was designed to assess whether B7-1 signalling constitutes a promising therapeutic pathway for DN. Mice injected with streptozotocin (STZ) were treated with abatacept and glycemia and renal function were assessed. No differences were found in diabetes progression, albumin excretion rates or albumin/creatine ratios, while mesangial expansion was unaltered at endpoint. Except for increased renal CCL5, treatment did not affect a panel of gene expression endpoints reflecting early fibrotic changes, inflammation and kidney injury. Finally, abatacept treatment effectively reduced the accumulation of activated CD4+ T cells in the kidney, suggesting that renal T cell inflammation is not a driving factor in the pathology of the STZ model. In conjunction with the recent data discounting the expression of B7-1 on podocytes, our present data do not support a role for abatacept in DN treatment. PMID:27055155

  14. Modelling disease introduction as biological control of invasive predators to preserve endangered prey.

    PubMed

    Oliveira, Nuno M; Hilker, Frank M

    2010-02-01

    Invasive species are a significant cause of bio-diversity loss particularly in island ecosystems. It has been suggested to release pathogenic parasites as an efficient control measure of these mostly immune-naïve populations. In order to explore the potential impacts of such bio-control approach, we construct and investigate mathematical models describing disease dynamics in a host population that acts as a predator embedded in a simple food chain. The consequences of Feline Immunodeficiency Virus (FIV) introduction into a closed ecosystem are addressed using a bi-trophic system, comprising an indigenous prey (birds) and an introduced predator (cats). Our results show that FIV is unlikely to fully eradicate cats on sub-Antarctic islands, but it can be efficient in depressing their population size, allowing for the recovery of the endangered prey. Depending on the ecological setting and disease transmission mode (we consider proportionate mixing as well as mass action), successful pathogen invasion can induce population oscillations that are not possible in the disease-free predator-prey system. These fluctuations can be seen as a mixed blessing from a management point of view. On the one hand, they may increase the extinction risk of the birds. On the other hand, they provide an opportunity to eradicate cats more easily in combination with other methods such as trapping or culling. PMID:19787407

  15. Phosphodiesterase 7 Inhibition Preserves Dopaminergic Neurons in Cellular and Rodent Models of Parkinson Disease

    PubMed Central

    Morales-Garcia, Jose A.; Redondo, Miriam; Alonso-Gil, Sandra; Gil, Carmen; Perez, Concepción; Martinez, Ana; Santos, Angel; Perez-Castillo, Ana

    2011-01-01

    Background Phosphodiesterase 7 plays a major role in down-regulation of protein kinase A activity by hydrolyzing cAMP in many cell types. This cyclic nucleotide plays a key role in signal transduction in a wide variety of cellular responses. In the brain, cAMP has been implicated in learning, memory processes and other brain functions. Methodology/Principal Findings Here we show a novel function of phosphodiesterase 7 inhibition on nigrostriatal dopaminergic neuronal death. We found that S14, a heterocyclic small molecule inhibitor of phosphodiesterase 7, conferred significant neuronal protection against different insults both in the human dopaminergic cell line SH-SY5Y and in primary rat mesencephalic cultures. S14 treatment also reduced microglial activation, protected dopaminergic neurons and improved motor function in the lipopolysaccharide rat model of Parkinson disease. Finally, S14 neuroprotective effects were reversed by blocking the cAMP signaling pathways that operate through cAMP-dependent protein kinase A. Conclusions/Significance Our findings demonstrate that phosphodiesterase 7 inhibition can protect dopaminergic neurons against different insults, and they provide support for the therapeutic potential of phosphodiesterase 7 inhibitors in the treatment of neurodegenerative disorders, particularly Parkinson disease. PMID:21390306

  16. Acceptance, values, and probability.

    PubMed

    Steel, Daniel

    2015-10-01

    This essay makes a case for regarding personal probabilities used in Bayesian analyses of confirmation as objects of acceptance and rejection. That in turn entails that personal probabilities are subject to the argument from inductive risk, which aims to show non-epistemic values can legitimately influence scientific decisions about which hypotheses to accept. In a Bayesian context, the argument from inductive risk suggests that value judgments can influence decisions about which probability models to accept for likelihoods and priors. As a consequence, if the argument from inductive risk is sound, then non-epistemic values can affect not only the level of evidence deemed necessary to accept a hypothesis but also degrees of confirmation themselves. PMID:26386533

  17. Examining the Intention to Use Technology among Pre-Service Teachers: An Integration of the Technology Acceptance Model and Theory of Planned Behavior

    ERIC Educational Resources Information Center

    Teo, Timothy

    2012-01-01

    This study examined pre-service teachers' self-reported intention to use technology. One hundred fifty-seven participants completed a survey questionnaire measuring their responses to six constructs from a research model that integrated the Technology Acceptance Model (TAM) and Theory of Planned Behavior (TPB). Structural equation modeling was…

  18. Factors That Influence the Acceptance of Telemetry by Emergency Medical Technicians in Ambulances: An Application of the Extended Technology Acceptance Model

    PubMed Central

    Hwang, Ji Young; Kim, Ki Young

    2014-01-01

    Abstract Objective: The aim of the study was to verify the effects of patient factors perceived by emergency medical technicians (EMTs) as well as their social and organizational factors on prehospital telemetry use intention based on the technology use intention and elaboration likelihood models. Materials and Methods: This is a retrospective empirical study. Questionnaires were developed on the basis of clinical factors of 72,907 patients assessed by prehospital telemetry from January 1, 2009 to April 30, 2012 by reviewing their prehospital medical care records and in-hospital medical records. Questionnaires regarding the social and organizational factors of EMTs were created on the basis of a literature review. To verify which factors affect the utilization of telemetry, we developed a partial least-squares route model on the basis of each characteristic. In total, 136 EMTs who had experience in using prehospital telemetry were surveyed from April 1 to April 7, 2013. Reliability, validity, hypotheses, and the model goodness of fit of the study tools were tested. Results: The clinical factors of the patients (path coefficient=−0.12; t=2.38), subjective norm (path coefficient=0.18; t=2.63), and job fit (path coefficient=0.45; t=5.29) positively affected the perceived usefulness (p<0.010). Meanwhile, the clinical factors of the patients (path coefficients=−0.19; t=4.46), subjective norm (path coefficient=0.08; t=1.97), loyalty incentives (path coefficient=−0.17; t=3.83), job fit (path coefficient=−0.32; t=7.06), organizational facilitations (path coefficient=0.08; t=1.99), and technical factors (i.e., usefulness and ease of use) positively affected attitudes (path coefficient=0.10, 0.58; t=2.62, 5.81; p<0.010). Attitudes and perceived usefulness significantly positively affected use intention. Conclusions: Factors that influence the use of telemetry by EMTs in ambulances included patients' clinical factors, as well as complex organizational and

  19. Coupled inverse and forward modelling to assess the range of acceptable thermal histories, a case study from SE Brazil

    NASA Astrophysics Data System (ADS)

    Cogné, N.; Gallagher, K.; Cobbold, P. R.

    2012-04-01

    We performed a new thermochronological study (fission track analysis and (U-Th)/He dating on apatite) in SE Brazil and integrate those data with inverse and forward modelling via QTQt software (Gallagher, 2012) to obtain thermal histories. The inversion results were used to characterize the general thermal histories and the associated uncertainties. For most of the samples we had a first phase of cooling during Late Cretaceous or Early Tertiary with subsequent reheating followed by Neogene cooling. The inverse modelling does not provide a unique solution and the associated uncertainties can be quite significant. Moreover the Tertiary parts of thermal histories were usually near the accepted resolution of the thermochronometric methods (~50-40°C). Therefore we performed deterministic forward modelling within the range of uncertainties to assess which solution is the most consistent with the data and independent geological information. These results are always conditional on the assumed kinetics for fission track annealing and diffusion of He, so we do not test the validity of that aspect. However, we can look at the range of predictions for the different forward models tested. This apporach implies that the reheating is required only for the samples around onshore Tertiary basins. For other samples we cannot conclude but geological information are against this hypothesis. However the Neogene cooling is required for all the samples.The combination of forward and inverse modelling allows us to better constrain the thermal histories for each sample in exploring the range of uncertainties and to reconcile a range of possible thermal histories with independent geological information. It also provides new information on the contrasting thermal evolution between different regions of the onshore SE Brazilian margin. Gallagher, K. 2012, Transdimensional Inverse thermal history modeling for quantitative thermochronology, Journal of Geophysical Research, in press.

  20. ESTIMATING THE ECONOMIC VALUE OF NATIONAL PARKS WITH COUNT DATA MODELS USING ON-SITE, SECONDARY DATA: THE CASE OF THE GREAT SAND DUNES NATIONAL PARK AND PRESERVE

    EPA Science Inventory

    We estimate an individual travel cost model for Great Sand Dunes National Park and Preserve (GSD) in Colorado using on-site, secondary data. The purpose of the on-site survey was to help the National Park Service better understand the visitors of GSD; it was not intended for a t...

  1. Acceptance speech.

    PubMed

    Carpenter, M

    1994-01-01

    In Bangladesh, the assistant administrator of USAID gave an acceptance speech at an awards ceremony on the occasion of the 25th anniversary of oral rehydration solution (ORS). The ceremony celebrated the key role of the International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B) in the discovery of ORS. Its research activities over the last 25 years have brought ORS to every village in the world, preventing more than a million deaths each year. ORS is the most important medical advance of the 20th century. It is affordable and client-oriented, a true appropriate technology. USAID has provided more than US$ 40 million to ICDDR,B for diarrheal disease and measles research, urban and rural applied family planning and maternal and child health research, and vaccine development. ICDDR,B began as the relatively small Cholera Research Laboratory and has grown into an acclaimed international center for health, family planning, and population research. It leads the world in diarrheal disease research. ICDDR,B is the leading center for applied health research in South Asia. It trains public health specialists from around the world. The government of Bangladesh and the international donor community have actively joined in support of ICDDR,B. The government applies the results of ICDDR,B research to its programs to improve the health and well-being of Bangladeshis. ICDDR,B now also studies acute respiratory diseases and measles. Population and health comprise 1 of USAID's 4 strategic priorities, the others being economic growth, environment, and democracy, USAID promotes people's participation in these 4 areas and in the design and implementation of development projects. USAID is committed to the use and improvement of ORS and to complementary strategies that further reduce diarrhea-related deaths. Continued collaboration with a strong user perspective and integrated services will lead to sustainable development. PMID:12345470

  2. Acceptance speech.

    PubMed

    Yusuf, C K

    1994-01-01

    I am proud and honored to accept this award on behalf of the Government of Bangladesh, and the millions of Bangladeshi children saved by oral rehydration solution. The Government of Bangladesh is grateful for this recognition of its commitment to international health and population research and cost-effective health care for all. The Government of Bangladesh has already made remarkable strides forward in the health and population sector, and this was recognized in UNICEF's 1993 "State of the World's Children". The national contraceptive prevalence rate, at 40%, is higher than that of many developed countries. It is appropriate that Bangladesh, where ORS was discovered, has the largest ORS production capacity in the world. It was remarkable that after the devastating cyclone in 1991, the country was able to produce enough ORS to meet the needs and remain self-sufficient. Similarly, Bangladesh has one of the most effective, flexible and efficient control of diarrheal disease and epidemic response program in the world. Through the country, doctors have been trained in diarrheal disease management, and stores of ORS are maintained ready for any outbreak. Despite grim predictions after the 1991 cyclone and the 1993 floods, relatively few people died from diarrheal disease. This is indicative of the strength of the national program. I want to take this opportunity to acknowledge the contribution of ICDDR, B and the important role it plays in supporting the Government's efforts in the health and population sector. The partnership between the Government of Bangladesh and ICDDR, B has already borne great fruit, and I hope and believe that it will continue to do so for many years in the future. Thank you. PMID:12345479

  3. Health research access to personal confidential data in England and Wales: assessing any gap in public attitude between preferable and acceptable models of consent.

    PubMed

    Taylor, Mark J; Taylor, Natasha

    2014-12-01

    England and Wales are moving toward a model of 'opt out' for use of personal confidential data in health research. Existing research does not make clear how acceptable this move is to the public. While people are typically supportive of health research, when asked to describe the ideal level of control there is a marked lack of consensus over the preferred model of consent (e.g. explicit consent, opt out etc.). This study sought to investigate a relatively unexplored difference between the consent model that people prefer and that which they are willing to accept. It also sought to explore any reasons for such acceptance.A mixed methods approach was used to gather data, incorporating a structured questionnaire and in-depth focus group discussions led by an external facilitator. The sampling strategy was designed to recruit people with different involvement in the NHS but typically with experience of NHS services. Three separate focus groups were carried out over three consecutive days.The central finding is that people are typically willing to accept models of consent other than that which they would prefer. Such acceptance is typically conditional upon a number of factors, including: security and confidentiality, no inappropriate commercialisation or detrimental use, transparency, independent overview, the ability to object to any processing considered to be inappropriate or particularly sensitive.This study suggests that most people would find research use without the possibility of objection to be unacceptable. However, the study also suggests that people who would prefer to be asked explicitly before data were used for purposes beyond direct care may be willing to accept an opt out model of consent if the reasons for not seeking explicit consent are accessible to them and they trust that data is only going to be used under conditions, and with safeguards, that they would consider to be acceptable even if not preferable. PMID:26085451

  4. Testing a model for parental acceptance of human papillomavirus vaccine in 9- to 18-year-old girls: a theory-guided study.

    PubMed

    Reynolds, Diane; O'Connell, Kathleen A

    2012-12-01

    Gardasil is the first vaccine developed to prevent cervical cancer and other diseases caused by certain types of genital human papillomavirus in females, but little is known about parental acceptance of this vaccine. The purpose of this study was to test a model that predicts intention to vaccinate that includes constructs from the health belief model and the theory of reasoned action. PMID:22020360

  5. Bridging between NMA and Elastic Network Models: Preserving All-Atom Accuracy in Coarse-Grained Models

    PubMed Central

    Na, Hyuntae; Jernigan, Robert L.; Song, Guang

    2015-01-01

    Dynamics can provide deep insights into the functional mechanisms of proteins and protein complexes. For large protein complexes such as GroEL/GroES with more than 8,000 residues, obtaining a fine-grained all-atom description of its normal mode motions can be computationally prohibitive and is often unnecessary. For this reason, coarse-grained models have been used successfully. However, most existing coarse-grained models use extremely simple potentials to represent the interactions within the coarse-grained structures and as a result, the dynamics obtained for the coarse-grained structures may not always be fully realistic. There is a gap between the quality of the dynamics of the coarse-grained structures given by all-atom models and that by coarse-grained models. In this work, we resolve an important question in protein dynamics computations—how can we efficiently construct coarse-grained models whose description of the dynamics of the coarse-grained structures remains as accurate as that given by all-atom models? Our method takes advantage of the sparseness of the Hessian matrix and achieves a high efficiency with a novel iterative matrix projection approach. The result is highly significant since it can provide descriptions of normal mode motions at an all-atom level of accuracy even for the largest biomolecular complexes. The application of our method to GroEL/GroES offers new insights into the mechanism of this biologically important chaperonin, such as that the conformational transitions of this protein complex in its functional cycle are even more strongly connected to the first few lowest frequency modes than with other coarse-grained models. PMID:26473491

  6. A Patient Survey Assessing the Awareness and Acceptability of the Emergency Care Summary and Its Consent Model in Scotland

    PubMed Central

    Johnstone, Chris; McCartney, Gerry

    2010-01-01

    Background The Emergency Care Summary (ECS) was introduced in 2006 to allow aspects of the general practitioner (GP; family doctor, equivalent to primary care physician) medical record to be viewed in hospitals and out-of-hours centers in Scotland. Records were automatically uploaded unless patients actively opted out. This study investigated patient awareness and acceptance of this process. Methods This was a questionnaire survey of patients in a GP surgery (office) in Paisley, Scotland. Results Survey results indicated that 42 percent of patients were aware of the ECS, and 16 percent said that they recognized the leaflet posted to households. Of those who recognized the leaflet, 92 percent said they were happy for their record to be part of the system, while the others did not realize their record was to be included. Having read the leaflet, 97 percent said that they were happy for their record to be included in the ECS. Conclusions This study shows that most patients were not aware of the Emergency Care Summary or did not remember seeing the leaflet posted to households. Having read the leaflet, the vast majority of patients were happy for their records to be included in the system. The low awareness of the ECS calls into question the validity of an implied consent model using an information leaflet distributed by post. PMID:20697469

  7. Acceptance and Commitment Therapy and Contextual Behavioral Science: Examining the Progress of a Distinctive Model of Behavioral and Cognitive Therapy

    PubMed Central

    Hayes, Steven C.; Levin, Michael E.; Plumb-Vilardaga, Jennifer; Villatte, Jennifer L.; Pistorello, Jacqueline

    2012-01-01

    A number of recent authors have compared acceptance and commitment therapy (ACT) and traditional cognitive behavior therapy (CBT). The present article describes ACT as a distinct and unified model of behavior change, linked to a specific strategy of scientific development, which we term “contextual behavioral science.” We outline the empirical progress of ACT and describe its distinctive development strategy. A contextual behavioral science approach is an inductive attempt to build more adequate psychological systems based on philosophical clarity; the development of basic principles and theories; the development of applied theories linked to basic ones; techniques and components linked to these processes and principles; measurement of theoretically key processes; an emphasis on mediation and moderation in the analysis of applied impact; an interest in effectiveness, dissemination, and training; empirical testing of the research program across a broad range of areas and levels of analysis; and the creation of a more effective scientific and clinical community. We argue that this is a reasonable approach, focused on long-term progress, and that in broad terms it seems to be working. ACT is not hostile to traditional CBT, and is not directly buoyed by whatever weaknesses traditional CBT may have. ACT should be measured at least in part against its own goals as specified by its own developmental strategy. PMID:23611068

  8. Quantitative and qualitative variation of fat in model vanilla custard desserts: effects on sensory properties and consumer acceptance.

    PubMed

    Tomaschunas, Maja; Köhn, Ehrhard; Bennwitz, Petra; Hinrichs, Jörg; Busch-Stockfisch, Mechthild

    2013-06-01

    The effects of variation in fat content (0.1% to 15.8%) and type of fat, using different types of milk, dairy cream, or vegetable fat cream, on sensory characteristics and consumer acceptance of starch-based vanilla model custards were studied. Descriptive analysis with trained panelists and consumer testing with untrained assessors were applied. Descriptive data were related to hedonic data using principal component analysis to determine drivers of liking and disliking. Results demonstrated an increasing effect of fat concerning visual and oral thickness, creamy flavor, and fat-related texture properties, as well as a decreasing effect concerning yellow color and surface shine. A lack of fat caused moderate intensities in pudding-like flavor attributes and an intensive jelly texture. Adding a vegetable fat cream led to lower intensities in attributes yellow color, cooked flavor, thick, and jelly texture, whereas intensities in vegetable fat flavor and fat-related texture properties increased. All consumers favored custards with medium fat contents, being high in pudding-like and vegetable fat flavor as well as in fat-related texture attributes. Nonfat custards were rejected due to jelly texture and moderate intensities in pudding-flavor attributes. High-fat samples were liked by some consumers, but their high intensities in thickness, white color, and creamy flavor also drove disliking for others. PMID:23772708

  9. Valproate Attenuates Nitroglycerin-Induced Trigeminovascular Activation by Preserving Mitochondrial Function in a Rat Model of Migraine.

    PubMed

    Li, Ruxian; Liu, Yushuang; Chen, Nan; Zhang, Yitong; Song, Ge; Zhang, Zhongling

    2016-01-01

    BACKGROUND Migraine is a chronic disease that interferes with life quality and work productivity. Valproate shows protective effects against migraine, yet the underlying mechanisms are unclear. This study aimed to evaluate the potential effect of valproate on migraine using a rat model of nitroglycerin-induced trigeminovascular activation, as well as to explore the underlying mechanism. MATERIAL AND METHODS Intraperitoneal injection of nitroglycerin was conducted to induce trigeminovascular activation in rats. To explore the protective effect of valproate, a low dose (100 mg/kg) or a high dose (200 mg/kg) of valproate was intraperitoneally injected into rats, and then the levels of 5-hydroxytryptamine and nitric oxide in the peripheral blood were examined. The mtDNA copy number and the protein levels of peroxisome proliferator-activated receptor-γ coactivator 1α, mitochondrial transcription factor A, and peroxisome proliferator-activated receptor-γ in the spinal trigeminal nucleus were detected to evaluate the biogenesis of mitochondria. The mitochondrial energy metabolism was determined by the mitochondrial membrane potential and the levels of adenosine triphosphate, cytochrome C oxidase, and reactive oxygen species. RESULTS Valproate attenuated nitroglycerin-induced trigeminovascular activation in rats, with reduced scratching behavior and restored 5-hydroxytryptamine and nitric oxide levels. Moreover, the mitochondrial energy metabolism and the biogenesis of mitochondria were preserved by valproate in nitroglycerin-treated rats. CONCLUSIONS The protective effect of valproate against migraine may be achieved through the modulation of mitochondrial biogenesis and function. Our study provides evidence for the potential use of valproate in the treatment of migraine. PMID:27618395

  10. DRP1 inhibition rescues retinal ganglion cells and their axons by preserving mitochondrial integrity in a mouse model of glaucoma.

    PubMed

    Kim, K-Y; Perkins, G A; Shim, M S; Bushong, E; Alcasid, N; Ju, S; Ellisman, M H; Weinreb, R N; Ju, W-K

    2015-01-01

    Glaucoma is the leading cause of irreversible blindness and is characterized by slow and progressive degeneration of the optic nerve head axons and retinal ganglion cell (RGC), leading to loss of visual function. Although oxidative stress and/or alteration of mitochondrial (mt) dynamics induced by elevated intraocular pressure (IOP) are associated with this neurodegenerative disease, the mechanisms that regulate mt dysfunction-mediated glaucomatous neurodegeneration are poorly understood. Using a mouse model of glaucoma, DBA/2J (D2), which spontaneously develops elevated IOP, as well as an in vitro RGC culture system, we show here that oxidative stress, as evidenced by increasing superoxide dismutase 2 (SOD2) and mt transcription factor A (Tfam) protein expression, triggers mt fission and loss by increasing dynamin-related protein 1 (DRP1) in the retina of glaucomatous D2 mice as well as in cultured RGCs exposed to elevated hydrostatic pressure in vitro. DRP1 inhibition by overexpressing DRP1 K38A mutant blocks mt fission and triggers a subsequent reduction of oxidative stress, as evidenced by decreasing SOD2 and Tfam protein expression. DRP1 inhibition promotes RGC survival by increasing phosphorylation of Bad at serine 112 in the retina and preserves RGC axons by maintaining mt integrity in the glial lamina of glaucomatous D2 mice. These findings demonstrate an important vicious cycle involved in glaucomatous neurodegeneration that starts with elevated IOP producing oxidative stress; the oxidative stress then leads to mt fission and a specific form of mt dysfunction that generates further oxidative stress, thus perpetuating the cycle. Our findings suggest that DRP1 is a potential therapeutic target for ameliorating oxidative stress-mediated mt fission and dysfunction in RGC and its axons during glaucomatous neurodegeneration. Thus, DRP1 inhibition may provide a new therapeutic strategy for protecting both RGCs and their axons in glaucoma and other optic

  11. Preservation of Digital Objects.

    ERIC Educational Resources Information Center

    Galloway, Patricia

    2004-01-01

    Presents a literature review that covers the following topics related to preservation of digital objects: practical examples; stakeholders; recordkeeping standards; genre-specific problems; trusted repository standards; preservation methods; preservation metadata standards; and future directions. (Contains 82 references.) (MES)

  12. Perceptions of a Specific Family Communication Application among Grandparents and Grandchildren: An Extension of the Technology Acceptance Model

    PubMed Central

    Tsai, Tsai-Hsuan; Chang, Hsien-Tsung; Ho, Yi-Lun

    2016-01-01

    Many studies have noted that the use of social networks sites (SNSs) can enhance social interaction among the elderly and that the motivation for the elderly to use SNSs is to keep in contact with remote friends and family or the younger generation. Memotree is designed to promote intergenerational family communication. The system incorporates the Family Tree design concept and provides family communication mechanisms based on the Family Communication Scale. In addition, the system optimizes hardware and interface use to conform to the specific needs of older and substantially younger individuals. Regarding the impact of variables on SNS with respect to the interaction of usability variables in the construction of a cross-generational communication platform, we adopted the TAM model and Chung et al.’s suggestions to promote user acceptance of the proposed Memotree system. A total of 39 grandchildren and 39 grandparents met the criteria and were included in the study. The elderly and young respondents revealed substantial willingness to use and/or satisfaction with using the Memotree system. Empirical results indicate that technology affordances and perceived ease of use have a positive impact on perceived usefulness, while perceived ease of use is affected by technology affordances. Internet self-efficacy and perceived usefulness have a positive impact on the user’s behavioral intention toward the system. In addition, this study investigated age as a moderating variable in the model. The results indicate that grandchildren have a larger significant effect on the path between perceived usefulness and behavioral intention than grandparents. This study proposes a more complete framework for investigating the user’s behavioral intention and provides a more appropriate explanation of related services for cross-generational interaction with SNS services. PMID:27270915

  13. Perceptions of a Specific Family Communication Application among Grandparents and Grandchildren: An Extension of the Technology Acceptance Model.

    PubMed

    Tsai, Tsai-Hsuan; Chang, Hsien-Tsung; Ho, Yi-Lun

    2016-01-01

    Many studies have noted that the use of social networks sites (SNSs) can enhance social interaction among the elderly and that the motivation for the elderly to use SNSs is to keep in contact with remote friends and family or the younger generation. Memotree is designed to promote intergenerational family communication. The system incorporates the Family Tree design concept and provides family communication mechanisms based on the Family Communication Scale. In addition, the system optimizes hardware and interface use to conform to the specific needs of older and substantially younger individuals. Regarding the impact of variables on SNS with respect to the interaction of usability variables in the construction of a cross-generational communication platform, we adopted the TAM model and Chung et al.'s suggestions to promote user acceptance of the proposed Memotree system. A total of 39 grandchildren and 39 grandparents met the criteria and were included in the study. The elderly and young respondents revealed substantial willingness to use and/or satisfaction with using the Memotree system. Empirical results indicate that technology affordances and perceived ease of use have a positive impact on perceived usefulness, while perceived ease of use is affected by technology affordances. Internet self-efficacy and perceived usefulness have a positive impact on the user's behavioral intention toward the system. In addition, this study investigated age as a moderating variable in the model. The results indicate that grandchildren have a larger significant effect on the path between perceived usefulness and behavioral intention than grandparents. This study proposes a more complete framework for investigating the user's behavioral intention and provides a more appropriate explanation of related services for cross-generational interaction with SNS services. PMID:27270915

  14. 7 CFR 3560.660 - Acceptance of prepayments.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Acceptance of prepayments. 3560.660 Section 3560.660... AGRICULTURE DIRECT MULTI-FAMILY HOUSING LOANS AND GRANTS Housing Preservation § 3560.660 Acceptance of...) Prepayment must be made 180 days from the date of the Agency's prepayment acceptance notice to the...

  15. 7 CFR 3560.660 - Acceptance of prepayments.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Acceptance of prepayments. 3560.660 Section 3560.660... AGRICULTURE DIRECT MULTI-FAMILY HOUSING LOANS AND GRANTS Housing Preservation § 3560.660 Acceptance of...) Prepayment must be made 180 days from the date of the Agency's prepayment acceptance notice to the...

  16. Modeling the Interrelationships among Pre-Service Science Teachers' Understanding and Acceptance of Evolution, Their Views on Nature of Science and Self-Efficacy Beliefs regarding Teaching Evolution

    ERIC Educational Resources Information Center

    Akyol, Gulsum; Tekkaya, Ceren; Sungur, Semra; Traynor, Anne

    2012-01-01

    This study proposed a path model of relationships among understanding and acceptance of evolution, views on nature of science, and self-efficacy beliefs regarding teaching evolution. A total of 415 pre-service science teachers completed a series of self-report instruments for the specified purpose. After the estimation of scale scores using…

  17. Assessing the Intention to Use Technology among Pre-Service Teachers in Singapore and Malaysia: A Multigroup Invariance Analysis of the Technology Acceptance Model (TAM)

    ERIC Educational Resources Information Center

    Teo, Timothy; Lee, Chwee Beng; Chai, Ching Sing; Wong, Su Luan

    2009-01-01

    This study assesses the pre-service teachers' self-reported future intentions to use technology in Singapore and Malaysia. A survey was employed to validate items from past research. Using the Technology Acceptance Model (TAM) as a research framework, 495 pre-service teachers from Singapore and Malaysia responded to an 11-item questionnaires…

  18. Analysis of Utility and Use of a Web-Based Tool for Digital Signal Processing Teaching by Means of a Technological Acceptance Model

    ERIC Educational Resources Information Center

    Toral, S. L.; Barrero, F.; Martinez-Torres, M. R.

    2007-01-01

    This paper presents an exploratory study about the development of a structural and measurement model for the technological acceptance (TAM) of a web-based educational tool. The aim consists of measuring not only the use of this tool, but also the external variables with a significant influence in its use for planning future improvements. The tool,…

  19. Re-examining the role of attitude in information system acceptance: a model from the satisfaction-dissatisfaction perspective

    NASA Astrophysics Data System (ADS)

    Guo, Bin; Zhou, Shasha

    2016-05-01

    This study attempts to re-examine the role of attitude in voluntary information system (IS) acceptance and usage, which has often been discounted in the previous technology acceptance research. We extend the unidimensional view of attitude into a bidimensional one, because of the simultaneous existence of both positive and negative evaluation towards IS in technology acceptance behaviour. In doing so, attitude construct is divided into two components: satisfaction as the positive attitudinal component and dissatisfaction as the negative attitudinal component. We argue that satisfaction and dissatisfaction will interactively affect technology usage intention. Besides, we explore the predictors of satisfaction and dissatisfaction based on the disconfirmation theory. Empirical results from a longitudinal study on bulletin board system (BBS) usage confirm the interaction effect of satisfaction and dissatisfaction on usage intention. Moreover, perceived task-related value has a significant effect on satisfaction, while perceived personal value has a significant effect on dissatisfaction. We also discuss the theoretical and managerial implications of our findings.

  20. UGV acceptance testing

    NASA Astrophysics Data System (ADS)

    Kramer, Jeffrey A.; Murphy, Robin R.

    2006-05-01

    With over 100 models of unmanned vehicles now available for military and civilian safety, security or rescue applications, it is important to for agencies to establish acceptance testing. However, there appears to be no general guidelines for what constitutes a reasonable acceptance test. This paper describes i) a preliminary method for acceptance testing by a customer of the mechanical and electrical components of an unmanned ground vehicle system, ii) how it has been applied to a man-packable micro-robot, and iii) discusses the value of testing both to ensure that the customer has a workable system and to improve design. The test method automated the operation of the robot to repeatedly exercise all aspects and combinations of components on the robot for 6 hours. The acceptance testing process uncovered many failures consistent with those shown to occur in the field, showing that testing by the user does predict failures. The process also demonstrated that the testing by the manufacturer can provide important design data that can be used to identify, diagnose, and prevent long-term problems. Also, the structured testing environment showed that sensor systems can be used to predict errors and changes in performance, as well as uncovering unmodeled behavior in subsystems.

  1. Fertility-preserving surgical procedures, techniques.

    PubMed

    Martinez, Alejandra; Poilblanc, Mathieu; Ferron, Gwenael; De Cuypere, Mariolene; Jouve, Eva; Querleu, Denis

    2012-06-01

    As a result of the trend toward late childbearing, fertility preservation has become a major issue in young women with gynaecological cancer. Fertility-sparing treatments have been successfully attempted in selected cases of cervical, endometrial and ovarian cancer, and gynaecologists should be familiar with fertility-preserving options in women with gynaecological malignancies. Options to preserve fertility include shielding to reduce radiation damage, fertility preservation when undergoing cytotoxic treatments, cryopreservation, assisted reproduction techniques, and fertility-sparing surgical procedures. Radical vaginal trachelectomy with laparoscopic lymphadenectomy is an oncologically safe, fertility-preserving procedure. It has been accepted worldwide as a surgical treatment of small early stage cervical cancers. Selected cases of early stage ovarian cancer can be treated by unilateral salpingo-ophorectomy and surgical staging. Hysteroscopic resection and progesterone treatment are used in young women who have endometrial cancer to maintain fertility and avoid surgical menopause. Appropriate patient selection, and careful oncologic, psychologic, reproductive and obstetric counselling, is mandatory. PMID:22503435

  2. A Model of Acceptance of Web 2.0 in Learning in Higher Education: A Case Study of Two Cultures

    ERIC Educational Resources Information Center

    Usoro, Abel; Echeng, Razep; Majewski, Grzegorz

    2014-01-01

    Though a few empirical studies on acceptance of Web 2.0 as a social networking tool in teaching and learning exist, apparently none consider students' and faculties' views from different cultures, which is the focus of this study. This article reports on a pilot study that begins to fill this gap by investigating the perceptions,…

  3. Personal Learning Environments Acceptance Model: The Role of Need for Cognition, e-Learning Satisfaction and Students' Perceptions

    ERIC Educational Resources Information Center

    del Barrio-García, Salvador; Arquero, José L.; Romero-Frías, Esteban

    2015-01-01

    As long as students use Web 2.0 tools extensively for social purposes, there is an opportunity to improve students' engagement in Higher Education by using these tools for academic purposes under a Personal Learning Environment approach (PLE 2.0). The success of these attempts depends upon the reactions and acceptance of users towards e-learning…

  4. Learner Differences in Perceived Satisfaction of an Online Learning: An Extension to the Technology Acceptance Model in an Arabic Sample

    ERIC Educational Resources Information Center

    Al-Azawei, Ahmed; Lundqvist, Karsten

    2015-01-01

    Online learning constitutes the most popular distance-learning method, with flexibility, accessibility, visibility, manageability and availability as its core features. However, current research indicates that its efficacy is not consistent across all learners. This study aimed to modify and extend the factors of the Technology Acceptance Model…

  5. E-Learning and the University of Huelva: A Study of WebCT and the Technological Acceptance Model

    ERIC Educational Resources Information Center

    Sanchez, R. Arteaga; Hueros, A. Duarte; Ordaz, M. Garcia

    2013-01-01

    Purpose: The purpose of this paper is to investigate the factors that determine the acceptance of the WebCT learning system among students of the faculties of Business and Education Sciences at the University of Huelva, and to verify the direct and indirect effects of these factors. Design/methodology/approach: A total of 226 students at the…

  6. 75 FR 26270 - Environmental Planning and Historic Preservation Compliance Costs Policy; Environmental Planning...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-11

    ... SECURITY Federal Emergency Management Agency Environmental Planning and Historic Preservation Compliance Costs Policy; Environmental Planning and Historic Preservation Mitigation Policy AGENCY: Federal... Emergency Management Agency (FEMA) is accepting comments on a draft Environmental Planning and...

  7. Preservation Of Native Aortic Valve Flow And Full Hemodynamic Support With The TORVAD™ Using A Computational Model Of The Cardiovascular System

    PubMed Central

    Gohean, Jeffrey R.; George, Mitchell J.; Chang, Kay-Won; Larson, Erik R.; Pate, Thomas D.; Kurusz, Mark; Longoria, Raul G.; Smalling, Richard W.

    2014-01-01

    This paper describes the stroke volume selection and operational design for the TORVAD™, a synchronous, positive-displacement ventricular assist device (VAD). A lumped parameter model was used to simulate hemodynamics with the TORVAD™ compared to those under continuous flow VAD support. Results from the simulation demonstrated that a TORVAD™ with a 30 mL stroke volume ejecting with an early diastolic counterpulse provides comparable systemic support to the HeartMate II® (HMII) (cardiac output 5.7 L/min up from 3.1 L/min in simulated heart failure). By taking advantage of synchronous pulsatility, the TORVAD™ delivers full hemodynamic support with nearly half the VAD flow rate (2.7 L/min compared to 5.3 L/min for the HMII) by allowing the left ventricle to eject during systole, thus preserving native aortic valve flow (3.0 L/min compared to 0.4 L/min for the HMII, down from 3.1 L/min at baseline). The TORVAD™ also preserves pulse pressure (26.7 mmHg compared to 12.8 mmHg for the HMII, down from 29.1 mmHg at baseline). Preservation of aortic valve flow with synchronous pulsatile support could reduce the high incidence of aortic insufficiency and valve cusp fusion reported in patients supported with continuous flow VADs. PMID:25485562

  8. Testing the Technology Acceptance Model: HIV Case Managers' Intention to Use a Continuity of Care Record with Context-specific Links

    PubMed Central

    Bakken, Suzanne

    2014-01-01

    Objective The goal of this study was to examine the applicability of the Technology Acceptance Model (TAM) in explaining Human Immunodeficiency Virus (HIV) case managers’ acceptance of a prototype Continuity of Care Record (CCR) with context-specific links designed to meet their information needs. Design An online survey, based on the constructs of the Technology Acceptance Model (TAM), of 94 case managers who provide care to persons living with HIV (PLWH). To assess the consistency, reliability and fit of the model factors, three methods were used: principal components factor analysis, Cronbach’s alpha, and regression analysis. Results Principal components factor analysis resulted in three factors (Perceived Ease of Use, Perceived Usefulness, and Barriers to Use) that explained 84.88% of the variance. Internal consistency reliability estimates ranged from .69–.91. In a linear regression model, Perceived Ease of Use, Perceived Usefulness, and Barriers to Use scores explained 43.6% (p <.001) of the variance in Behavioral Intention to use a CCR with context-specific links. Conclusion Our study validated the use of the TAM in health information technology.Results from our study demonstrated that Perceived Ease of Use, Perceived Usefulness, and Barriers to Use are predictors of Behavioral Intention to use a CCR with context-specific links to web-based information resources. PMID:21848452

  9. Using combined hydrological variables for extracting functional signatures of catchments to better assess the acceptability of model structures in conceptual catchment modelling

    NASA Astrophysics Data System (ADS)

    Fovet, O.; Hrachowitz, M.; RUIZ, L.; Gascuel-odoux, C.; Savenije, H.

    2013-12-01

    While most hydrological models reproduce the general flow dynamics of a system, they frequently fail to adequately mimic system internal processes. This is likely to make them inadequate to simulate solutes transport. For example, the hysteresis between storage and discharge, which is often observed in shallow hard-rock aquifers, is rarely well reproduced by models. One main reason is that this hysteresis has little weight in the calibration because objective functions are based on time series of individual variables. This reduces the ability of classical calibration/validation procedures to assess the relevance of the conceptual hypothesis associated with hydrological models. Calibrating models on variables derived from the combination of different individual variables (like stream discharge and groundwater levels) is a way to insure that models will be accepted based on their consistency. Here we therefore test the value of this more systems-like approach to test different hypothesis on the behaviour of a small experimental low-land catchment in French Brittany (ORE AgrHys) where a high hysteresis is observed on the stream flow vs. shallow groundwater level relationship. Several conceptual models were applied to this site, and calibrated using objective functions based on metrics of this hysteresis. The tested model structures differed with respect to the storage function in each reservoir, the storage-discharge function in each reservoir, the deep loss expressions (as constant or variable fraction), the number of reservoirs (from 1 to 4) and their organization (parallel, series). The observed hysteretic groundwater level-discharge relationship was not satisfactorily reproduced by most of the tested models except for the most complex ones. Those were thus more consistent, their underlying hypotheses are probably more realistic even though their performance for simulating observed stream flow was decreased. Selecting models based on such systems-like approach is

  10. An exceptionally preserved Late Devonian actinopterygian provides a new model for primitive cranial anatomy in ray-finned fishes.

    PubMed

    Giles, Sam; Darras, Laurent; Clément, Gaël; Blieck, Alain; Friedman, Matt

    2015-10-01

    Actinopterygians (ray-finned fishes) are the most diverse living osteichthyan (bony vertebrate) group, with a rich fossil record. However, details of their earliest history during the middle Palaeozoic (Devonian) 'Age of Fishes' remains sketchy. This stems from an uneven understanding of anatomy in early actinopterygians, with a few well-known species dominating perceptions of primitive conditions. Here we present an exceptionally preserved ray-finned fish from the Late Devonian (Middle Frasnian, ca 373 Ma) of Pas-de-Calais, northern France. This new genus is represented by a single, three-dimensionally preserved skull. CT scanning reveals the presence of an almost complete braincase along with near-fully articulated mandibular, hyoid and gill arches. The neurocranium differs from the coeval Mimipiscis in displaying a short aortic canal with a distinct posterior notch, long grooves for the lateral dorsal aortae, large vestibular fontanelles and a broad postorbital process. Identification of similar but previously unrecognized features in other Devonian actinopterygians suggests that aspects of braincase anatomy in Mimipiscis are apomorphic, questioning its ubiquity as stand-in for generalized actinopterygian conditions. However, the gill skeleton of the new form broadly corresponds to that of Mimipiscis, and adds to an emerging picture of primitive branchial architecture in crown gnathostomes. The new genus is recovered in a polytomy with Mimiidae and a subset of Devonian and stratigraphically younger actinopterygians, with no support found for a monophyletic grouping of Moythomasia with Mimiidae. PMID:26423841

  11. An exceptionally preserved Late Devonian actinopterygian provides a new model for primitive cranial anatomy in ray-finned fishes

    PubMed Central

    Giles, Sam; Darras, Laurent; Clément, Gaël; Blieck, Alain; Friedman, Matt

    2015-01-01

    Actinopterygians (ray-finned fishes) are the most diverse living osteichthyan (bony vertebrate) group, with a rich fossil record. However, details of their earliest history during the middle Palaeozoic (Devonian) ‘Age of Fishes' remains sketchy. This stems from an uneven understanding of anatomy in early actinopterygians, with a few well-known species dominating perceptions of primitive conditions. Here we present an exceptionally preserved ray-finned fish from the Late Devonian (Middle Frasnian, ca 373 Ma) of Pas-de-Calais, northern France. This new genus is represented by a single, three-dimensionally preserved skull. CT scanning reveals the presence of an almost complete braincase along with near-fully articulated mandibular, hyoid and gill arches. The neurocranium differs from the coeval Mimipiscis in displaying a short aortic canal with a distinct posterior notch, long grooves for the lateral dorsal aortae, large vestibular fontanelles and a broad postorbital process. Identification of similar but previously unrecognized features in other Devonian actinopterygians suggests that aspects of braincase anatomy in Mimipiscis are apomorphic, questioning its ubiquity as stand-in for generalized actinopterygian conditions. However, the gill skeleton of the new form broadly corresponds to that of Mimipiscis, and adds to an emerging picture of primitive branchial architecture in crown gnathostomes. The new genus is recovered in a polytomy with Mimiidae and a subset of Devonian and stratigraphically younger actinopterygians, with no support found for a monophyletic grouping of Moythomasia with Mimiidae. PMID:26423841

  12. Formax Preserved Birds

    ERIC Educational Resources Information Center

    Sheridan, Philip

    1978-01-01

    A quick, simple method for preserving bird specimens using borax and a formalin solution is described. Procedures for injecting and mounting the specimens are given along with certain restrictions on preserving specimens. (MA)

  13. CONTAMINANTS AND REMEDIAL OPTIONS AT WOOD PRESERVING SITES

    EPA Science Inventory

    This document provides information that facilitates characterization of the site and selection of treatment technologies at wood preserving sites, to meet the regulations’ acceptable cleanup levels. It does not provide risk-assessment information or policy guidance related to det...

  14. Preserving socially expected crowd density in front of an exit for the reproduction of experimental data by modeling pedestrians' rear perception

    NASA Astrophysics Data System (ADS)

    Mahmod Shuaib, Mohammed

    2014-10-01

    In this article, we discuss different approaches and mechanisms implemented in the social force model regarding its role in obtaining real-life data. In crowd evacuation processes, preserving normal crowd density at an exit is crucial. Here, we introduce a new mechanism for the reproduction of specific flow rate within the range stated in the literature. For the implementation of this mechanism into the social force model, an association between the pedestrians' social responsibility to relieve any unusual crowd density in front of an exit and a reduction in their competition behavior is presented, where the pedestrians' perception of what is behind them is the main factor in this association. Accordingly, a model is proposed for rear perception subject to the production of the fundamental diagram and the specific flow rate, while conserving the inter-pedestrian dynamics by which the social force model is characterized. Simulations are conducted to demonstrate the validity of this mechanism.

  15. Texture-preserved penalized weighted least-squares reconstruction of low-dose CT image via image segmentation and high-order MRF modeling

    NASA Astrophysics Data System (ADS)

    Han, Hao; Zhang, Hao; Wei, Xinzhou; Moore, William; Liang, Zhengrong

    2016-03-01

    In this paper, we proposed a low-dose computed tomography (LdCT) image reconstruction method with the help of prior knowledge learning from previous high-quality or normal-dose CT (NdCT) scans. The well-established statistical penalized weighted least squares (PWLS) algorithm was adopted for image reconstruction, where the penalty term was formulated by a texture-based Gaussian Markov random field (gMRF) model. The NdCT scan was firstly segmented into different tissue types by a feature vector quantization (FVQ) approach. Then for each tissue type, a set of tissue-specific coefficients for the gMRF penalty was statistically learnt from the NdCT image via multiple-linear regression analysis. We also proposed a scheme to adaptively select the order of gMRF model for coefficients prediction. The tissue-specific gMRF patterns learnt from the NdCT image were finally used to form an adaptive MRF penalty for the PWLS reconstruction of LdCT image. The proposed texture-adaptive PWLS image reconstruction algorithm was shown to be more effective to preserve image textures than the conventional PWLS image reconstruction algorithm, and we further demonstrated the gain of high-order MRF modeling for texture-preserved LdCT PWLS image reconstruction.

  16. Ischaemia-related cell damage in extracorporeal preserved tissue – new findings with a novel perfusion model

    PubMed Central

    Taeger, Christian D; Müller-Seubert, Wibke; Horch, Raymund E; Präbst, Konstantin; Münch, Frank; Geppert, Carol I; Birkholz, Torsten; Dragu, Adrian

    2014-01-01

    Tissue undergoing free transfer in transplant or reconstructive surgery always is at high risk of ischaemia-related cell damage. This study aims at assessing different procedures using an extracorporeal perfusion and oxygenation system to investigate the expression of hypoxia inducible factor (HIF)-1-α as marker for hypoxia and of the pro-apoptotic protein Caspase-3 in skeletal muscle to elucidate potential improvements in tissue conservation. Twenty-four porcine rectus abdominis muscles were assigned to five different groups and examined after they had been extracorporeally preserved for 60 min. time. Group I was left untreated (control), group II was perfused with a cardioplegic solution, group III was flushed with 10 ml of a cardioplegic solution and then left untreated. Group IV and V were perfused and oxygenated with either an isotone crystalloid solution or a cardioplegic solution. Among others, immunohistochemistry (Caspase-3 and HIF-1-α) of muscle samples was performed. Furthermore, oxygen partial pressure in the perfusate at the arterial and venous branch was measured. Expression of Caspase-3 after 60 min. was reduced in all groups compared to the control group. Furthermore, all groups (except group III) expressed less HIF-1-α than the control group. Oxygenation leads to higher oxygen levels at the venous branch compared to groups without oxygenation. Using an extracorporeal perfusion and oxygenation system cell damage could be reduced as indicated by stabilized expressions of Caspase-3 and HIF-1-α for 60 min. of tissue preservation. Complete depletion of oxygen at the venous branch can be prevented by oxygenation of the perfusate with ambient air. PMID:24636195

  17. Lowstand versus highstand eustatic models for peat preservation: The coal-bearing rocks of the Breathitt Group, Eastern Kentucky

    SciTech Connect

    Chesnut, D.R. Jr.; Greb, S.F. . Kentucky Geological Survey)

    1992-01-01

    Stratigraphic and chronologic studies suggest that the alternation between major coal beds and clastic rocks of the Lower and Middle Pennsylvanian Breathitt Group (Central Appalachian Basin) resulted from glacial eustacy. The typical Coal-Clastic cycle starts at the top of a major coal bed and consists of a coarsening-upward sequence of marine or brackish-water strata which is commonly truncated and overlain by a fining-upward sequence. The fining-upward sequence is overlain by a rooted paleosol which is overlain by a coal bed. In one scenario, the peat is deposited during the stable highstand period. Because of subsidence, the highstand peat deposit is drowned and covered by marine sediments. During the subsequent lowstand the marine strata are eroded to varying degrees and bare channels are developed, causing an erosional unconformity surface on the marine strata. During transgression, the rise in base-level causes sediments to aggrade within the channels, creating fining-upward sequences above the marine strata. Paleosol development and peat deposition begin again at the next highstand. In another scenario peats are deposited in a coastal setting during lowstand. As transgression proceeds from lowstand, channels backfill and all low-lying areas including peat are covered by coarsening-upward sequences. Peats are then deposited on exposed platforms during highstand. During the subsequent drop in sea level, channels are incised and highstand peats and part of the coarsening-upward sediment package is eroded. The second scenario implies a preservation bias to cyclothems caused by eustatic rates being greater than subsidence rates. Peats are probably deposited during both lowstand and highstand, but lowstand peats are more likely to be preserved.

  18. Bone Marrow–Derived Mesenchymal Stem Cells Enhance Bacterial Clearance and Preserve Bioprosthetic Integrity in a Model of Mesh Infection

    PubMed Central

    Criman, Erik T.; Kurata, Wendy E.; Matsumoto, Karen W.; Aubin, Harry T.; Campbell, Carmen E.

    2016-01-01

    Background: The reported incidence of mesh infection in contaminated operative fields is as high as 30% regardless of the material used. Recently, mesenchymal stem cells (MSCs) have been shown to possess favorable immunomodulatory properties and improve tissue incorporation when seeded onto bioprosthetics. The aim of this study was to evaluate whether seeding noncrosslinked bovine pericardium (Veritas Collagen Matrix) with allogeneic bone marrow–derived MSCs improves infection resistance in vivo after inoculation with Escherichia coli (E. coli). Methods: Rat bone marrow–derived MSCs at passage 3 were seeded onto bovine pericardium and cultured for 7 days before implantation. Additional rats (n = 24) were implanted subcutaneously with MSC-seeded or unseeded mesh and inoculated with 7 × 105 colony-forming units of E. coli or saline before wound closure (group 1, unseeded mesh/saline; group 2, unseeded mesh/E. coli; group 3, MSC-seeded mesh/E. coli; 8 rats per group). Meshes were explanted at 4 weeks and underwent microbiologic and histologic analyses. Results: MSC-seeded meshes inoculated with E. coli demonstrated superior bacterial clearance and preservation of mesh integrity compared with E. coli–inoculated unseeded meshes (87.5% versus 0% clearance; p = 0.001). Complete mesh degradation concurrent with abscess formation was observed in 100% of rats in the unseeded/E. coli group, which is in contrast to 12.5% of rats in the MSC-seeded/E. coli group. Histologic evaluation determined that remodeling characteristics of E. coli–inoculated MSC-seeded meshes were similar to those of uninfected meshes 4 weeks after implantation. Conclusions: Augmenting a bioprosthetic material with stem cells seems to markedly enhance resistance to bacterial infection in vivo and preserve mesh integrity. PMID:27482490

  19. "It's all about acceptance": A qualitative study exploring a model of positive body image for people with spinal cord injury.

    PubMed

    Bailey, K Alysse; Gammage, Kimberley L; van Ingen, Cathy; Ditor, David S

    2015-09-01

    Using modified constructivist grounded theory, the purpose of the present study was to explore positive body image experiences in people with spinal cord injury. Nine participants (five women, four men) varying in age (21-63 years), type of injury (C3-T7; complete and incomplete), and years post-injury (4-36 years) were recruited. The following main categories were found: body acceptance, body appreciation and gratitude, social support, functional gains, independence, media literacy, broadly conceptualizing beauty, inner positivity influencing outer demeanour, finding others who have a positive body image, unconditional acceptance from others, religion/spirituality, listening to and taking care of the body, managing secondary complications, minimizing pain, and respect. Interestingly, there was consistency in positive body image characteristics reported in this study with those found in previous research, demonstrating universality of positive body image. However, unique characteristics (e.g., resilience, functional gains, independence) were also reported demonstrating the importance of exploring positive body image in diverse groups. PMID:26002149

  20. Preserving electronic records: Not the easiest task

    NASA Technical Reports Server (NTRS)

    Eaton, Fynnette

    1993-01-01

    The National Archives and Records Administration has had a program for accessioning, describing, preserving and providing reference service to the electronic records (machine-readable records) created by Federal agencies for more than twenty years. Although there have been many changes in the name of the office, its basic mission has remained the same: to preserve and make available those records created by Federal agencies that the National Archives has determined to have value beyond the short-term need of the originating agency. A phrase that was once coined for a preservation conference still applies: the National Archives, when it decides to accept the transfer of records into its custody, is committing itself to preserving these records for perpetuity.

  1. Comparison between Utsu's and Vere-Jones' aftershocks model by means of a computer simulation based on the acceptance-rejection sampling of von Neumann

    NASA Astrophysics Data System (ADS)

    Reyes, J.; Morales-Esteban, A.; González, E.; Martínez-Álvarez, F.

    2016-07-01

    In this research, a new algorithm for generating a stochastic earthquake catalog is presented. The algorithm is based on the acceptance-rejection sampling of von Neumann. The result is a computer simulation of earthquakes based on the calculated statistical properties of each zone. Vere-Jones states that an earthquake sequence can be modeled as a series of random events. This is the model used in the proposed simulation. Contrariwise, Utsu indicates that the mainshocks are special geophysical events. The algorithm has been applied to zones of Chile, China, Spain, Japan, and the USA. This allows classifying the zones according to Vere-Jones' or Utsu's model. The results have been quantified relating the mainshock with the largest aftershock within the next 5 days (which has been named as Bath event). The results show that some zones fit Utsu's model and others Vere-Jones'. Finally, the fraction of seismic events that satisfy certain properties of magnitude and occurrence is analyzed.

  2. Coopersmith Self-Esteem: Two Different Hypothesized Factor Models--Both Acceptable for the Same Data Structure.

    ERIC Educational Resources Information Center

    Hofmann, Rich; Sherman, Larry

    Using data from 135 sixth-, seventh-, and eighth-graders between 11 and 15 years old attending a middle school in a suburban Southwest Ohio school district, two hypothesized models of the factor structures for the Coopersmith Self-Esteem Inventory were tested. One model represents the original Coopersmith factor structure, and the other model is…

  3. [Preservatives in ophthalmology].

    PubMed

    Messmer, E M

    2012-11-01

    Preservatives are a legal requirement for eye drops in multidose containers. Moreover, they are necessary for stabilization and intraocular penetration for a number of ophthalmic preparations. Most preservatives act in a relatively unspecific manner as detergents or by oxidative mechanisms and thereby cause side effects at the ocular surface. They may also affect the lens, trabecular meshwork and the retina. Benzalkonium chloride is the most commonly used preservative in ophthalmology and is more toxic than other or newer preservatives, such as polyquaternium-1 (Polyquad), sodium perborate, oxychloro-complex (Purite®) and SofZia. Preservative-free topical medication is highly recommended for patients with ocular surface disease, frequent eye drop administration, proven allergy to preservatives and contact lens wear. PMID:23179809

  4. Environmental preservation demand: Altruistic, bequest, and intrinsic motives

    SciTech Connect

    Whitehead, J.C.; Thompson, C.Y. )

    1993-01-01

    When the demand for environmental preservation is not explicitly revealed in markets, motivating attitudes toward environmental preservation become important. A survey approach allows revelation and measurement of demand for environmental preservation. Indices which measure the altruistic, bequest, intrinsic, and option to use motives and other attitudes are utilized as determinants in a model that measures the demand for environmental preservation. Demand is more likely with greater preservation motives. Preservation demand also depends on individual preferences for economic development, perceptions of affordability and responsibility for preservation of the wetlands. 17 refs., 3 tabs.

  5. Modeling lactose hydrolysis for efficiency and selectivity: Toward the preservation of sialyloligosaccharides in bovine colostrum whey permeate.

    PubMed

    de Moura Bell, Juliana M L N; Aquino, Leticia F M C; Liu, Yan; Cohen, Joshua L; Lee, Hyeyoung; de Melo Silva, Vitor L; Rodrigues, Maria I; Barile, Daniela

    2016-08-01

    Enzymatic hydrolysis of lactose has been shown to improve the efficiency and selectivity of membrane-based separations toward the recovery of bioactive oligosaccharides. Achieving maximum lactose hydrolysis requires intrinsic process optimization for each specific substrate, but the effects of those processing conditions on the target oligosaccharides are not well understood. Response surface methodology was used to investigate the effects of pH (3.25-8.25), temperature (35-55°C), reaction time (6 to 58 min), and amount of enzyme (0.05-0.25%) on the efficiency of lactose hydrolysis by β-galactosidase and on the preservation of biologically important sialyloligosaccharides (3'-siallylactose, 6'-siallylactose, and 6'-sialyl-N-acetyllactosamine) naturally present in bovine colostrum whey permeate. A central composite rotatable design was used. In general, β-galactosidase activity was favored at pH values ranging from 3.25 to 5.75, with other operational parameters having a less pronounced effect. A pH of 4.5 allowed for the use of a shorter reaction time (19 min), lower temperature (40°C), and reduced amount of enzyme (0.1%), but complete hydrolysis at a higher pH (5.75) required greater values for these operational parameters. The total amount of sialyloligosaccharides was not significantly altered by the reaction parameters evaluated, suggesting specificity of β-galactosidase from Aspergillus oryzae toward lactose as well as the stability of the oligosaccharides at pH, temperature, and reaction time evaluated. PMID:27236766

  6. Laboratories for the 21st Century: Best Practices; Modeling Exhaust Dispersion for Specifying Acceptable Exhaust/Intake Design (Brochure)

    SciTech Connect

    Not Available

    2011-09-01

    This guide provides general information on specifying acceptable exhaust and intake designs. It also provides various quantitative approaches that can be used to determine expected concentration levels resulting from exhaust system emissions. In addition, the guide describes methodologies that can be employed to operate laboratory exhaust systems in a safe and energy efficient manner by using variable air volume (VAV) technology. The guide, one in a series on best practices for laboratories, was produced by Laboratories for the 21st Century (Labs21), a joint program of the U.S. Environmental Protection Agency (EPA) and the U.S. Department of Energy (DOE). Geared toward architects, engineers, and facility managers, the guides contain information about technologies and practices to use in designing, constructing, and operating safe, sustainable, high-performance laboratories. Studies show a direct relationship between indoor air quality and the health and productivity of building occupants. Historically, the study and protection of indoor air quality focused on emission sources emanating from within the building. For example, to ensure that the worker is not exposed to toxic chemicals, 'as manufactured' and 'as installed' containment specifications are required for fume hoods. However, emissions from external sources, which may be re-ingested into the building through closed circuiting between the building's exhaust stacks and air intakes, are an often overlooked aspect of indoor air quality.

  7. Advances in corneal preservation.

    PubMed Central

    Lindstrom, R L

    1990-01-01

    The functional status of the endothelium and sustained corneal deturgescence after corneal preservation are of great clinical importance and have been primary goals in the development of corneal storage media. In our investigational studies we have specifically addressed the improvement of the quality of donor tissue after 4 degrees C storage, the extension of corneal preservation time, the enhancement of corneal wound healing, and the reduction of the normal progressive loss of endothelial cells postkeratoplasty. Specifically we have developed in vitro HCE cell and epithelial cell culture models that can accurately reflect the response of human corneal tissue in vivo. These models have been utilized to study the effects of growth factors and medium components in relation to their biocompatibility and efficacy in the development of improved corneal preservation solutions. Our laboratory investigated in vitro conditions that allowed human corneal endothelium to shift from a nonproliferative state, in which they remain viable and metabolically active, to a proliferative, mitotically active state. Isolation techniques developed in our laboratory have enabled the establishment of primary and subsequent subcultures of human corneal endothelium that retain the attributes of native endothelium. These in vitro conditions maintain HCE cells in a proliferative state, actively undergoing mitosis. A quantitative bioassay has been developed to determine the effects of various test medium in the stimulation or inhibition of DNA synthesis. In attempting to learn more about the events that occur during in vitro endothelial cell isolation, cell reattachment, extracellular matrix interaction and migrating during subculture, SEM was done on isolated HCE cells incubated in CSM. These studies suggest that the components of the extracellular matrix modulate the growth response of HCE cells, and play a role in regulating proliferation and migration. These observations are important in

  8. Gender and Acceptance of E-Learning: A Multi-Group Analysis Based on a Structural Equation Model among College Students in Chile and Spain

    PubMed Central

    2015-01-01

    The scope of this study was to evaluate whether the adoption of e-learning in two universities, and in particular, the relationship between the perception of external control and perceived ease of use, is different because of gender differences. The study was carried out with participating students in two different universities, one in Chile and one in Spain. The Technology Acceptance Model was used as a theoretical framework for the study. A multi-group analysis method in partial least squares was employed to relate differences between groups. The four main conclusions of the study are: (1) a version of the Technology Acceptance Model has been successfully used to explain the process of adoption of e-learning at an undergraduate level of study; (2) the finding of a strong and significant relationship between perception of external control and perception of ease of use of the e-learning platform; (3) a significant relationship between perceived enjoyment and perceived ease of use and between results demonstrability and perceived usefulness is found; (4) the study indicates a few statistically significant differences between males and females when adopting an e-learning platform, according to the tested model. PMID:26465895

  9. Gender and Acceptance of E-Learning: A Multi-Group Analysis Based on a Structural Equation Model among College Students in Chile and Spain.

    PubMed

    Ramírez-Correa, Patricio E; Arenas-Gaitán, Jorge; Rondán-Cataluña, F Javier

    2015-01-01

    The scope of this study was to evaluate whether the adoption of e-learning in two universities, and in particular, the relationship between the perception of external control and perceived ease of use, is different because of gender differences. The study was carried out with participating students in two different universities, one in Chile and one in Spain. The Technology Acceptance Model was used as a theoretical framework for the study. A multi-group analysis method in partial least squares was employed to relate differences between groups. The four main conclusions of the study are: (1) a version of the Technology Acceptance Model has been successfully used to explain the process of adoption of e-learning at an undergraduate level of study; (2) the finding of a strong and significant relationship between perception of external control and perception of ease of use of the e-learning platform; (3) a significant relationship between perceived enjoyment and perceived ease of use and between results demonstrability and perceived usefulness is found; (4) the study indicates a few statistically significant differences between males and females when adopting an e-learning platform, according to the tested model. PMID:26465895

  10. The non-uniformity of fossil preservation.

    PubMed

    Holland, Steven M

    2016-07-19

    The fossil record provides the primary source of data for calibrating the origin of clades. Although minimum ages of clades are given by the oldest preserved fossil, these underestimate the true age, which must be bracketed by probabilistic methods based on multiple fossil occurrences. Although most of these methods assume uniform preservation rates, this assumption is unsupported over geological timescales. On geologically long timescales (more than 10 Myr), the origin and cessation of sedimentary basins, and long-term variations in tectonic subsidence, eustatic sea level and sedimentation rate control the availability of depositional facies that preserve the environments in which species lived. The loss of doomed sediments, those with a low probability of preservation, imparts a secular trend to fossil preservation. As a result, the fossil record is spatially and temporally non-uniform. Models of fossil preservation should reflect this non-uniformity by using empirical estimates of fossil preservation that are spatially and temporally partitioned, or by using indirect proxies of fossil preservation. Geologically, realistic models of preservation will provide substantially more reliable estimates of the origination of clades.This article is part of the themed issue 'Dating species divergences using rocks and clocks'. PMID:27325828

  11. Preservation and storage of prepared ballistic gelatine.

    PubMed

    Mattijssen, E J A T; Alberink, I; Jacobs, B; van den Boogaard, Y

    2016-02-01

    The use of ballistic gelatine, generally accepted as a human muscle tissue simulant in wound ballistic studies, might be improved by adding a preservative (Methyl 4-hydroxybenzoate) which inhibits microbial growth. This study shows that replacing a part of the gelatine powder by the preservative does not significantly alter the penetration depth of projectiles. Storing prepared blocks of ballistic gelatine over time decreased the penetration depth of projectiles. Storage of prepared gelatine for 4 week already showed a significant effect on the penetration depth of projectiles. PMID:26773228

  12. [Hearing preservation: Better hearing with advanced technology].

    PubMed

    Rader, T; Helbig, S; Stöver, T; Baumann, U

    2014-05-01

    Preservation of residual hearing after cochlear implantation allows patients the synergetic use of electric and acoustic stimulation (EAS). The application of specific surgical and therapeutic techniques enables the reduction of inner ear trauma, which leads otherwise to complete hearing loss. Due to simultaneous electric and acoustic stimulation, speech understanding is improved especially in noise. EAS is a well-accepted therapeutic treatment for subjects with profound hearing loss in the higher frequencies and no or mild hearing loss in the low frequencies. Several Manufacturers offer individual soft electrodes specially designed for hearing preservation as well as combined electric-acoustic audio processors. PMID:24782208

  13. Post-consumer use efficacies of preservatives in personal care and topical drug products: relationship to preservative category.

    PubMed

    Ravita, Timothy D; Tanner, Ralph S; Ahearn, Donald G; Arms, Erin L; Crockett, Patrick W

    2009-01-01

    Ninety-six used personal care and topical OTC drug items collected from consumers in the USA were examined for the presence of microbial contaminants. Of the eye and face product type containing global preservative chemistries (i.e., acceptable for use in Japan without major restrictions), 55% yielded numbers of microorganisms in excess of 500 CFU/g (P < 0.1814). For the mascara products with global preservative chemistries, 79% yielded numbers of microorganisms in excess of 500 CFU/g (P < 0.024). Products containing global preservative chemistries accounted for 88% (n = 14) of the products that had microbial contents above 10(4) CFU/g (P < 0.001). Prominent contaminants were species of Staphylococcus, Pseudomonas, Klebsiella, Streptococcus, Lactobacillus, Bacillus, Corynebacterium, and yeast. In general, under the stress of consumer use, products preserved with global preservative chemistries did not maintain as adequate preservation as products with non-global preservatives. PMID:18802729

  14. Model approach to estimate the probability of accepting a lot of heterogeneously contaminated powdered food using different sampling strategies.

    PubMed

    Valero, Antonio; Pasquali, Frédérique; De Cesare, Alessandra; Manfreda, Gerardo

    2014-08-01

    Current sampling plans assume a random distribution of microorganisms in food. However, food-borne pathogens are estimated to be heterogeneously distributed in powdered foods. This spatial distribution together with very low level of contaminations raises concern of the efficiency of current sampling plans for the detection of food-borne pathogens like Cronobacter and Salmonella in powdered foods such as powdered infant formula or powdered eggs. An alternative approach based on a Poisson distribution of the contaminated part of the lot (Habraken approach) was used in order to evaluate the probability of falsely accepting a contaminated lot of powdered food when different sampling strategies were simulated considering variables such as lot size, sample size, microbial concentration in the contaminated part of the lot and proportion of contaminated lot. The simulated results suggest that a sample size of 100g or more corresponds to the lower number of samples to be tested in comparison with sample sizes of 10 or 1g. Moreover, the number of samples to be tested greatly decrease if the microbial concentration is 1CFU/g instead of 0.1CFU/g or if the proportion of contamination is 0.05 instead of 0.01. Mean contaminations higher than 1CFU/g or proportions higher than 0.05 did not impact on the number of samples. The Habraken approach represents a useful tool for risk management in order to design a fit-for-purpose sampling plan for the detection of low levels of food-borne pathogens in heterogeneously contaminated powdered food. However, it must be outlined that although effective in detecting pathogens, these sampling plans are difficult to be applied since the huge number of samples that needs to be tested. Sampling does not seem an effective measure to control pathogens in powdered food. PMID:24462218

  15. Modes of fossil preservation

    USGS Publications Warehouse

    Schopf, J.M.

    1975-01-01

    The processes of geologic preservation are important for understanding the organisms represented by fossils. Some fossil differences are due to basic differences in organization of animals and plants, but the interpretation of fossils has also tended to be influenced by modes of preservation. Four modes of preservation generally can be distinguished: (1) Cellular permineralization ("petrifaction") preserves anatomical detail, and, occasionally, even cytologic structures. (2) Coalified compression, best illustrated by structures from coal but characteristic of many plant fossils in shale, preserves anatomical details in distorted form and produces surface replicas (impressions) on enclosing matrix. (3) Authigenic preservation replicates surface form or outline (molds and casts) prior to distortion by compression and, depending on cementation and timing, may intergrade with fossils that have been subject to compression. (4) Duripartic (hard part) preservation is characteristic of fossil skeletal remains, predominantly animal. Molds, pseudomorphs, or casts may form as bulk replacements following dissolution of the original fossil material, usually by leaching. Classification of the kinds of preservation in fossils will aid in identifying the processes responsible for modifying the fossil remains of both animals and plants. ?? 1975.

  16. Privacy preserving interactive record linkage (PPIRL)

    PubMed Central

    Kum, Hye-Chung; Krishnamurthy, Ashok; Machanavajjhala, Ashwin; Reiter, Michael K; Ahalt, Stanley

    2014-01-01

    Objective Record linkage to integrate uncoordinated databases is critical in biomedical research using Big Data. Balancing privacy protection against the need for high quality record linkage requires a human–machine hybrid system to safely manage uncertainty in the ever changing streams of chaotic Big Data. Methods In the computer science literature, private record linkage is the most published area. It investigates how to apply a known linkage function safely when linking two tables. However, in practice, the linkage function is rarely known. Thus, there are many data linkage centers whose main role is to be the trusted third party to determine the linkage function manually and link data for research via a master population list for a designated region. Recently, a more flexible computerized third-party linkage platform, Secure Decoupled Linkage (SDLink), has been proposed based on: (1) decoupling data via encryption, (2) obfuscation via chaffing (adding fake data) and universe manipulation; and (3) minimum information disclosure via recoding. Results We synthesize this literature to formalize a new framework for privacy preserving interactive record linkage (PPIRL) with tractable privacy and utility properties and then analyze the literature using this framework. Conclusions Human-based third-party linkage centers for privacy preserving record linkage are the accepted norm internationally. We find that a computer-based third-party platform that can precisely control the information disclosed at the micro level and allow frequent human interaction during the linkage process, is an effective human–machine hybrid system that significantly improves on the linkage center model both in terms of privacy and utility. PMID:24201028

  17. Grafts for Ridge Preservation

    PubMed Central

    Jamjoom, Amal; Cohen, Robert E.

    2015-01-01

    Alveolar ridge bone resorption is a biologic phenomenon that occurs following tooth extraction and cannot be prevented. This paper reviews the vertical and horizontal ridge dimensional changes that are associated with tooth extraction. It also provides an overview of the advantages of ridge preservation as well as grafting materials. A Medline search among English language papers was performed in March 2015 using alveolar ridge preservation, ridge augmentation, and various graft types as search terms. Additional papers were considered following the preliminary review of the initial search that were relevant to alveolar ridge preservation. The literature suggests that ridge preservation methods and augmentation techniques are available to minimize and restore available bone. Numerous grafting materials, such as autografts, allografts, xenografts, and alloplasts, currently are used for ridge preservation. Other materials, such as growth factors, also can be used to enhance biologic outcome. PMID:26262646

  18. Insertion of 3-D-primitives in mesh-based representations: towards compact models preserving the details.

    PubMed

    Lafarge, Florent; Keriven, Renaud; Brédif, Mathieu

    2010-07-01

    We propose an original hybrid modeling process of urban scenes that represents 3-D models as a combination of mesh-based surfaces and geometric 3-D-primitives. Meshes describe details such as ornaments and statues, whereas 3-D-primitives code for regular shapes such as walls and columns. Starting from an 3-D-surface obtained by multiview stereo techniques, these primitives are inserted into the surface after being detected. This strategy allows the introduction of semantic knowledge, the simplification of the modeling, and even correction of errors generated by the acquisition process. We design a hierarchical approach exploring different scales of an observed scene. Each level consists first in segmenting the surface using a multilabel energy model optimized by -expansion and then in fitting 3-D-primitives such as planes, cylinders or tori on the obtained partition where relevant. Experiments on real meshes, depth maps and synthetic surfaces show good potential for the proposed approach. PMID:20236893

  19. Self-preserving cosmetics.

    PubMed

    Varvaresou, A; Papageorgiou, S; Tsirivas, E; Protopapa, E; Kintziou, H; Kefala, V; Demetzos, C

    2009-06-01

    Preservatives are added to products for two reasons: first, to prevent microbial spoilage and therefore to prolong the shelf life of the product; second, to protect the consumer from a potential infection. Although chemical preservatives prevent microbial growth, their safety is questioned by a growing segment of consumers. Therefore, there is a considerable interest in the development of preservative-free or self-preserving cosmetics. In these formulations traditional/chemical preservatives have been replaced by other cosmetic ingredients with antimicrobial properties that are not legislated as preservatives according to the Annex VI of the Commission Directive 76/768/EEC and the amending directives (2003/15/EC, 2007/17/EC and 2007/22/EC). 'Hurdle Technology', a technology that has been used for the control of product safety in the food industry since 1970s, has also been applied for the production of self-preserving cosmetics. 'Hurdle Technology' is a term used to describe the intelligent combination of different preservation factors or hurdles to deteriorate the growth of microorganisms. Adherence to current good manufacturing practice, appropriate packaging, careful choice of the form of the emulsion, low water activity and low or high pH values are significant variables for the control of microbial growth in cosmetic formulations. This paper describes the application of the basic principles of 'Hurdle Technology' in the production of self-preserving cosmetics. Multifunctional antimicrobial ingredients and plant-derived essential oils and extracts that are used as alternative or natural preservatives and are not listed in Annex VI of the Cosmetic Directive are also reported. PMID:19302511

  20. Student Attitudes towards and Use of ICT in Course Study, Work and Social Activity: A Technology Acceptance Model Approach

    ERIC Educational Resources Information Center

    Edmunds, Rob; Thorpe, Mary; Conole, Grainne

    2012-01-01

    The increasing use of information and communication technology (ICT) in higher education has been explored largely in relation to student experience of coursework and university life. Students' lives and experience beyond the university have been largely unexplored. Research into student experience of ICT used a validated model--the technology…

  1. The Adoption of Blended E-Learning Technology in Vietnam Using a Revision of the Technology Acceptance Model

    ERIC Educational Resources Information Center

    Tran, Khanh Ngo Nhu

    2016-01-01

    This study examines factors that determine the attitudes of learners toward a blended e-learning system (BELS) using data collected by questionnaire from a sample of 396 students involved in a BELS environment in Vietnam. A theoretical model is derived from previous studies and is analyzed and developed using structural equation modeling…

  2. Predicting the Use of Paired Programming: Applying the Attitudes of Application Development Managers through the Technology Acceptance Model

    ERIC Educational Resources Information Center

    Zecca, Mark S.

    2010-01-01

    Business managers who look for ways to cut costs face difficult questions about the efficiency and effectiveness of software engineering practices that are used to complete projects on time, on specification, and within budget (Johnson, 1995; Lindstrom & Jeffries, 2004). Theoretical models such as the Theory of Reasoned Action (TRA) have linked…

  3. Irradiation preservation of seafood: Literature review

    SciTech Connect

    Molton, P.M.

    1987-10-01

    The application of gamma-irradiation for extending the shelf life of seafood has been of interest for many years. This report reviews a number of studies on seafood irradiation conducted over the past several years. Topics covered include seafood irradiation techniques and dosages, species applicability and differences, the effects of packaging on seafood preservation, and changes in organoleptic acceptability as a result of irradiation. Particular attention is given to radiation effects (likely and unlikely) of concern to the public. These include the potential for generation of toxic chemical products, botulinum toxin production, and other health concerns. No scientifically defensible evidence of any kind was found for any harmful effect of irradiation of seafoods at the doses being considered (less than 300 krad), and all indications are that irradiation is an acceptable and needed additional tool for seafood preservation. 49 refs., 14 figs., 14 tabs.

  4. Acceptability of GM foods among Pakistani consumers.

    PubMed

    Ali, Akhter; Rahut, Dil Bahadur; Imtiaz, Muhammad

    2016-04-01

    In Pakistan majority of the consumers do not have information about genetically modified (GM) foods. In developing countries particularly in Pakistan few studies have focused on consumers' acceptability about GM foods. Using comprehensive primary dataset collected from 320 consumers in 2013 from Pakistan, this study analyzes the determinants of consumers' acceptability of GM foods. The data was analyzed by employing the bivariate probit model and censored least absolute deviation (CLAD) models. The empirical results indicated that urban consumers are more aware of GM foods compared to rural consumers. The acceptance of GM foods was more among females' consumers as compared to male consumers. In addition, the older consumers were more willing to accept GM food compared to young consumers. The acceptability of GM foods was also higher among wealthier households. Low price is the key factor leading to the acceptability of GM foods. The acceptability of the GM foods also reduces the risks among Pakistani consumers. PMID:27494790

  5. Organ reperfusion and preservation.

    PubMed

    Jamieson, Russell W; Friend, Peter J

    2008-01-01

    Organ transplantation is one of the medical success stories of the 20th century. Transplantation is, however, a victim of its own success with demand for organs far exceeding supply. The ischemia/reperfusion injury associated with organ transplantation is complex with interlinking cellular pathways and cascades. With increasing use of marginal organs and better understanding of the consequences of ischemia/reperfusion, enhanced organ preservation is required. Traditional static cold preservation cannot prevent ischemia/reperfusion injury, the low temperature itself is damaging and viability testing is limited. Donor preconditioning techniques to enhance organ preservation in advance of retrieval are starting to show convergence on several key pathways (HO-1 and cell apoptosis). Microdialysis and bioimpedence techniques may allow viability assessment during cold storage. Hypothermic machine perfusion has a role to play, particularly in preservation of kidneys from non-heart-beating donors although results of clinical trials are awaited. Normothermic preservation offers benefits over cold storage (at least experimentally) by avoiding damage induced by low temperature, minimising ischemia/reperfusion injury and allowing resuscitation of damaged organs. Normothermic preservation is likely to increase as the average quality of donor organs declines and clinical trials are needed. In the long term, normothermic preservation may be used, not just to resuscitate organs, but facilitate organ immunomodulation. PMID:17981540

  6. Establishment and metabolic analysis of a model microbial community for understanding trophic and electron accepting interactions of subsurface anaerobic environments

    PubMed Central

    2010-01-01

    Background Communities of microorganisms control the rates of key biogeochemical cycles, and are important for biotechnology, bioremediation, and industrial microbiological processes. For this reason, we constructed a model microbial community comprised of three species dependent on trophic interactions. The three species microbial community was comprised of Clostridium cellulolyticum, Desulfovibrio vulgaris Hildenborough, and Geobacter sulfurreducens and was grown under continuous culture conditions. Cellobiose served as the carbon and energy source for C. cellulolyticum, whereas D. vulgaris and G. sulfurreducens derived carbon and energy from the metabolic products of cellobiose fermentation and were provided with sulfate and fumarate respectively as electron acceptors. Results qPCR monitoring of the culture revealed C. cellulolyticum to be dominant as expected and confirmed the presence of D. vulgaris and G. sulfurreducens. Proposed metabolic modeling of carbon and electron flow of the three-species community indicated that the growth of C. cellulolyticum and D. vulgaris were electron donor limited whereas G. sulfurreducens was electron acceptor limited. Conclusions The results demonstrate that C. cellulolyticum, D. vulgaris, and G. sulfurreducens can be grown in coculture in a continuous culture system in which D. vulgaris and G. sulfurreducens are dependent upon the metabolic byproducts of C. cellulolyticum for nutrients. This represents a step towards developing a tractable model ecosystem comprised of members representing the functional groups of a trophic network. PMID:20497531

  7. Critical role of the STAT3 pathway in the cardioprotective efficacy of zoniporide in a model of myocardial preservation – the rat isolated working heart

    PubMed Central

    Gao, L; Tsun, J; Sun, L; Kwan, J; Watson, A; Macdonald, PS; Hicks, M

    2011-01-01

    BACKGROUND AND PURPOSE Ischemia-reperfusion injury plays an important role in the development of primary allograft failure after heart transplantation. Inhibition of the Na+/H+ exchanger is one of the most promising therapeutic strategies for treating ischemia-reperfusion injury. Here we have characterized the cardioprotective efficacy of zoniporide and the underlying mechanisms in a model of myocardial preservation using rat isolated working hearts. EXPERIMENTAL APPROACH Rat isolated hearts subjected to 6 h hypothermic (1–4°C) storage followed by 45 min reperfusion at 37°C were treated with zoniporide at different concentrations and timing. Recovery of cardiac function, levels of total and phosphorylated protein kinase B, extracellular signal-regulated kinase 1/2, glycogen synthase kinase-3β and STAT3 as well as cleaved caspase 3 were measured at the end of reperfusion. Lactate dehydrogenase release into coronary effluent before and post-storage was also measured. KEY RESULTS Zoniporide concentration-dependently improved recovery of cardiac function after reperfusion. The functional recovery induced by zoniporide was accompanied by up-regulation of p-extracellular signal-regulated kinase 1/2 and p-STAT3, and by reduction in lactate dehydrogenase release and cleaved caspase 3. There were no significant differences in any of the above indices when zoniporide was administered before, during or after ischemia. The STAT3 inhibitor, stattic, abolished zoniporide-induced improvements in functional recovery and up-regulation of p-STAT3 after reperfusion. CONCLUSIONS AND IMPLICATIONS Zoniporide is a potent cardioprotective agent and activation of STAT3 plays a critical role in the cardioprotective action of zoniporide. This agent shows promise as a supplement to storage solutions to improve preservation of donor hearts. PMID:20942815

  8. Pain acceptance and personal control in pain relief in two maternity care models: a cross-national comparison of Belgium and the Netherlands

    PubMed Central

    2010-01-01

    Background A cross-national comparison of Belgian and Dutch childbearing women allows us to gain insight into the relative importance of pain acceptance and personal control in pain relief in 2 maternity care models. Although Belgium and the Netherlands are neighbouring countries sharing the same language, political system and geography, they are characterised by a different organisation of health care, particularly in maternity care. In Belgium the medical risks of childbirth are emphasised but neutralised by a strong belief in the merits of the medical model. Labour pain is perceived as a needless inconvenience easily resolved by means of pain medication. In the Netherlands the midwifery model of care defines childbirth as a normal physiological process and family event. Labour pain is perceived as an ally in the birth process. Methods Women were invited to participate in the study by independent midwives and obstetricians during antenatal visits in 2004-2005. Two questionnaires were filled out by 611 women, one at 30 weeks of pregnancy and one within the first 2 weeks after childbirth either at home or in a hospital. However, only women having a hospital birth without obstetric intervention (N = 327) were included in this analysis. A logistic regression analysis has been performed. Results Labour pain acceptance and personal control in pain relief render pain medication use during labour less likely, especially if they occur together. Apart from this general result, we also find large country differences. Dutch women with a normal hospital birth are six times less likely to use pain medication during labour, compared to their Belgian counterparts. This country difference cannot be explained by labour pain acceptance, since - in contrast to our working hypothesis - Dutch and Belgian women giving birth in a hospital setting are characterised by a similar labour pain acceptance. Our findings suggest that personal control in pain relief can partially explain the

  9. Students Perception towards the Implementation of Computer Graphics Technology in Class via Unified Theory of Acceptance and Use of Technology (UTAUT) Model

    NASA Astrophysics Data System (ADS)

    Binti Shamsuddin, Norsila

    Technology advancement and development in a higher learning institution is a chance for students to be motivated to learn in depth in the information technology areas. Students should take hold of the opportunity to blend their skills towards these technologies as preparation for them when graduating. The curriculum itself can rise up the students' interest and persuade them to be directly involved in the evolvement of the technology. The aim of this study is to see how deep is the students' involvement as well as their acceptance towards the adoption of the technology used in Computer Graphics and Image Processing subjects. The study will be towards the Bachelor students in Faculty of Industrial Information Technology (FIIT), Universiti Industri Selangor (UNISEL); Bac. In Multimedia Industry, BSc. Computer Science and BSc. Computer Science (Software Engineering). This study utilizes the new Unified Theory of Acceptance and Use of Technology (UTAUT) to further validate the model and enhance our understanding of the adoption of Computer Graphics and Image Processing Technologies. Four (4) out of eight (8) independent factors in UTAUT will be studied towards the dependent factor.

  10. Establishment and metabolic analysis of a model microbial community for understanding trophic and electron accepting interactions of subsurface anaerobic environments

    SciTech Connect

    Miller, Lance D; Mosher, Jennifer J; Venkateswaran, Amudhan; Yang, Zamin Koo; Palumbo, Anthony Vito; Phelps, Tommy Joe; Podar, Mircea; Schadt, Christopher Warren; Keller, Martin

    2010-01-01

    Communities of microorganisms control the rates of key biogeochemical cycles, and are important for biotechnology, bioremediation, and industrial microbiological processes. For this reason, we constructed a model microbial community comprised of three species dependent on trophic interactions. The three species microbial community was comprised of Clostridium cellulolyticum, Desulfovibrio vulgaris Hildenborough, and Geobacter sulfurreducens and was grown under continuous culture conditions. Cellobiose served as the carbon and energy source for C. cellulolyticum, whereas D. vulgaris and G. sulfurreducens derived carbon and energy from the metabolic products of cellobiose fermentation and were provided with sulfate and fumarate respectively as electron acceptors.

  11. Tifft Farm Nature Preserve.

    ERIC Educational Resources Information Center

    Benjamin, Thomas B.; Gannon, David J.

    1980-01-01

    Described are the creation, development, activities, and programs of Tifft Farm, a 264-acre nature preserve and environmental education center in Buffalo, New York, constructed on a sanitary landfill. (BT)

  12. Mechanism of entanglement preservation

    SciTech Connect

    Tong Qingjun; An Junhong; Luo Honggang; Oh, C. H.

    2010-05-15

    We study the entanglement preservation of two qubits locally interacting with their reservoirs. We show that the existence of a bound state of the qubit and its reservoir and the non-Markovian effect are two essential ingredients and their interplay plays a crucial role in preserving the entanglement in the steady state. When the non-Markovian effect is neglected, the entanglement sudden death (ESD) is reproduced. On the other hand, when the non-Markovian is significantly strong but the bound state is absent, the phenomenon of the ESD and its revival is recovered. Our formulation presents a unified picture about the entanglement preservation and provides a clear clue on how to preserve the entanglement in quantum information processing.

  13. Undergraduate technical skills training guided by student tutors – Analysis of tutors' attitudes, tutees' acceptance and learning progress in an innovative teaching model

    PubMed Central

    Weyrich, Peter; Schrauth, Markus; Kraus, Bernd; Habermehl, Daniel; Netzhammer, Nicolai; Zipfel, Stephan; Jünger, Jana; Riessen, Reimer; Nikendei, Christoph

    2008-01-01

    Background Skills labs provide a sheltered learning environment. As close supervision and individual feedback were proven to be important in ensuring effective skills training, we implemented a cross-year peer tutor system in our skills lab of internal medicine that allowed intense training sessions with small learning groups (3–4 students) taught by one student tutor. Methods The expectations, experiences and criticisms of peer tutors regarding the tutor system for undergraduate skills lab training were investigated in the context of a focus group. In addition, tutees' acceptance of this learning model and of their student tutors was evaluated by means of a pre/post web-based survey. Results 14 voluntary senior students were intensely prepared by consultants for their peer tutor activity. 127 students participated in the project, 66.9% of which responded to the web-based survey (23 topics with help of 6-point Likert scale + free comments). Acceptance was very high (5.69 ± 0.07, mean ± SEM), and self-confidence ratings increased significantly after the intervention for each of the trained skills (average 1.96 ± 0.08, all p < 0.002). Tutors received high global ratings (5.50 ± 0.07) and very positive anonymous individual feedback from participants. 82% of tutees considered the peer teaching model to be sufficient, and a mere 1% expressed the wish for skills training to be provided by faculty staff only. Focus group analyses with tutors revealed 18 different topics, including profit in personal knowledge and personal satisfaction through teaching activities. The ratio of 1:4 tutor/tutees was regarded to be very beneficial for effective feedback, and the personalized online evaluation by tutees to be a strong motivator and helpful for further improvements. The tutors ascribed great importance to the continuous availability of a contact doctor in case of uncertainties. Conclusion This study demonstrates that peer teaching in undergraduate technical clinical

  14. Acceptance and commitment therapy (ACT): the foundation of the therapeutic model and an overview of its contribution to the treatment of patients with chronic physical diseases.

    PubMed

    Prevedini, Anna Bianca; Presti, Giovambattista; Rabitti, Elisa; Miselli, Giovanni; Moderato, Paolo

    2011-01-01

    Nowadays, treatment of chronic illnesses, such as stroke, cancer, chronic heart and respiratory diseases, osteoarthritis, diabetes, and so forth, account for the largest part of expenses in western countries national health systems. Moreover, these diseases are by far the leading causes of mortality in the world, representing 60% of all deaths. Any treatment aimed at targeting them might engage an individual for a large portion of his/her life so that personal and environmental factors can play a crucial role in modulating the person's quality of life and functioning, on top of any medical cure. Anxiety, depression, and distress for examples are not rare in patients with chronic diseases. Therefore, Cognitive and Behavior Therapy research has largely contributed in the last decades in identifying and programming interventions on such aspects as real and perceived social and family support, coping abilities, locus of control, self-efficacy that might help patients living with their chronic disease. More recently, third generation Cognitive-Behavior-Therapies, such as Dialectical Behavioral Therapy (DBT), Mindfulness Based Cognitive Therapy (MBCT), Functional Analytic Psychotherapy (FAP) and Acceptance, and Commitment Therapy (ACT) focused their attention and research efforts on developing intervention models targeting the needs of patients with a chronic disease. This paper has three aims. First is to briefly introduce ACT epistemological (Functional Contextualism) and theoretical (Relational Frame Theory) foundations as a stand point for understanding the peculiarity of ACT as a modern form of Clinical Behavior Analysis. The second aim is to introduce ACT clinical model and its six core processes (acceptance, defusion, present moment, self as a context, values and committed action) as both accountable, in their continuum, for psychological flexibility and inflexibility. Third, to present a brief overview of studies and outcomes of ACT intervention protocols and

  15. The Volume Regulation Graph versus the Ejection Fraction as Metrics of Left Ventricular Performance in Heart Failure with and without a Preserved Ejection Fraction: A Mathematical Model Study

    PubMed Central

    Faes, Theo JC; Kerkhof, Peter LM

    2015-01-01

    In left ventricular heart failure, often a distinction is made between patients with a reduced and a preserved ejection fraction (EF). As EF is a composite metric of both the end-diastolic volume (EDV) and the end-systolic ventricular volume (ESV), the lucidity of the EF is sometimes questioned. As an alternative, the ESV–EDV graph is advocated. This study identifies the dependence of the EF and the EDV–ESV graph on the major determinants of ventricular performance. Numerical simulations were made using a model of the systemic circulation, consisting of an atrium–ventricle valves combination; a simple constant pressure as venous filling system; and a three-element Windkessel extended with a venous system. ESV–EDV graphs and EFs were calculated using this model while varying one by one the filling pressure, diastolic and systolic ventricular elastances, and diastolic pressure in the aorta. In conclusion, the ESV–EDV graph separates between diastolic and systolic dysfunction while the EF encompasses these two pathologies. Therefore, the ESV–EDV graph can provide an advantage over EF in heart failure studies. PMID:26052232

  16. High-resolution Near-surface Permafrost Modeling for the 21st Century, Wrangell-St. Elias National Park and Preserve, Alaska

    NASA Astrophysics Data System (ADS)

    Panda, S. K.; Marchenko, S. S.; Romanovsky, V. E.; Swanson, D. K.

    2013-12-01

    Permafrost within most part of Wrangell-St. Elias National Park and Preserve (WRST) is discontinuous and warm i.e. within a few degrees of thawing. It is the physical foundation on which the ecosystems in the park rest. Thawing of permafrost alters this foundation, and can alter ecosystems and landscapes. Nonetheless, the data on permafrost condition and extent within WRST is limited. The current and future permafrost distribution and thickness of active layer can be modeled, given sufficient data about ground properties, vegetation, topography, and climate. We used GIPL 1.0 (Spatially Distributed Model of Permafrost Dynamics in Alaska) model; and downscaled climate forcing from 5 Global Circulation Models (GCM) that work best for Alaska and high-resolution soil landscape and ecotype maps from National Park Service (NPS) as model inputs to develop high-resolution permafrost maps for the recent past (2001-10) and the future decades (2050s and 2090s). The soil landscape and ecotype maps were derived from Landsat TM scenes (Jorgenson et al. 2008). The modeling effort resulted in recent and future permafrost maps of WRST at a spatial resolution of 28.5 m, the best resolution permafrost maps available for any part of Alaska. The model mapped 80% of WRST as underlain by near-surface permafrost during the decade of 2001-10 (Fig. 1) and predicted 50% decrease in the near-surface permafrost extent by 2050s owing to a 2 °C increase in the mean decadal air temperature and slightly higher precipitation. According to the 5 GCM projections, the decadal air temperature will increase by another 2 °C between 2050s and 2090s which will likely cause further increase in the ground temperature and decrease in the permafrost extent. The model predicts a meager 15% of WRST would still remain underlain by near-surface permafrost toward the end of the 21st century. Comparison of the modeled permafrost distribution with in situ observation of permafrost presence/absence at 430 sites

  17. ATLAS ACCEPTANCE TEST

    SciTech Connect

    J.C. COCHRANE; J.V. PARKER; ET AL

    2001-06-01

    The acceptance test program for Atlas, a 23 MJ pulsed power facility for use in the Los Alamos High Energy Density Hydrodynamics program, has been completed. Completion of this program officially releases Atlas from the construction phase and readies it for experiments. Details of the acceptance test program results and of machine capabilities for experiments will be presented.

  18. Oxygen absorbers in food preservation: a review.

    PubMed

    Cichello, Simon Angelo

    2015-04-01

    The preservation of packaged food against oxidative degradation is essential to establish and improve food shelf life, customer acceptability, and increase food security. Oxygen absorbers have an important role in the removal of dissolved oxygen, preserving the colour, texture and aroma of different food products, and importantly inhibition of food spoilage microbes. Active packaging technology in food preservation has improved over decades mostly due to the sealing of foods in oxygen impermeable package material and the quality of oxygen absorber. Ferrous iron oxides are the most reliable and commonly used oxygen absorbers within the food industry. Oxygen absorbers have been transformed from sachets of dried iron-powder to simple self-adhesive patches to accommodate any custom size, capacity and application. Oxygen concentration can be effectively lowered to 100 ppm, with applications spanning a wide range of food products and beverages across the world (i.e. bread, meat, fish, fruit, and cheese). Newer molecules that preserve packaged food materials from all forms of degradation are being developed, however oxygen absorbers remain a staple product for the preservation of food and pharmaceutical products to reduce food wastage in developed nations and increased food security in the developing & third world. PMID:25829570

  19. AB006. Penile preserving and reconstructive surgery

    PubMed Central

    Burnett, Arthur L.

    2016-01-01

    Penile preserving and reconstructive surgery is applied in the management of the primary tumor in penile cancer as well as severe genital anomalies or loss. Its indications relate to preserving successful sexual relationships and retaining quality of life. For penile cancer, it is acknowledged that the historical “gold standard” of surgical amputation of the penis that results in penile disfigurement or emasculation should not be uniformly accepted. The option of organ-preserving treatment is possible when oncologically feasible. With penile preservation, the objective is to maintain penile length, appearance and sensation as well as urethral integrity. For the low-risk primary tumor in penile cancer, determinants of the treatment plan involve the pathological definition of the disease and discussion with the patient regarding preference based on informed counseling and understanding of comparative risks (oncologic efficacy versus morbidity). Innovative surgical options for penile preservation include wide local excision, glansectomy, and glans resurfacing. Surgical reconstructive techniques, as dictated by the extent of the penile defect, include primary closure, closure using skins flaps and grafts, penile lengthening and/or enhancement, and neophalloplasty.

  20. A coupled model between mechanical deformation and chemical diffusion: An explanation for the preservation of chemical zonation in plagioclase at high temperatures

    NASA Astrophysics Data System (ADS)

    Zhong, Xin; Vrijmoed, Johannes; Moulas, Evangelos; Tajcmanová, Lucie

    2016-04-01

    Compositional zoning in metamorphic minerals have been generally recognized as an important geological feature to decipher the metamorphic history of rocks. The observed chemical zoning of, e.g. garnet, is commonly interpreted as disequilibrium between the fractionated inner core and the surrounding matrix. However, chemically zoned minerals were also observed in high grade rocks (T>800 degree C) where the duration of metamorphic processes was independently dated to take several Ma. This implies that temperature may not be the only factor that controls diffusion timescales, and grain scale pressure variation was proposed to be a complementary factor that may significantly contribute to the formation and preservation of chemical zoning in high temperature metamorphic minerals [Tajcmanová 2013, 2015]. Here, a coupled model is developed to simulate viscous deformation and chemical diffusion. The numerical approach considers the conservation of mass, momentum, and a constitutive relation developed from equilibrium thermodynamics. A compressible viscoelastic rheology is applied, which associates the volumetric change triggered by deformation and diffusion to a change of pressure. The numerical model is applied to the chemically zoned plagioclase rim described by [Tajcmanová 2014]. The diffusion process operating during the plagioclase rim formation can lead to a development of a pressure gradient. Such a pressure gradient, if maintained during ongoing viscous relaxation, can lead to the preservation of the observed chemical zonation in minerals. An important dimensionless number, the Deborah number, is defined as the ratio between the Maxwell viscoelastic relaxation time and the characteristic diffusion time. It characterizes the relative influence between the maintenance of grain scale pressure variation and chemical diffusion. Two extreme regimes are shown: the mechanically-controlled regime (high Deborah number) and diffusion-controlled regime (low Deborah number

  1. A PROBABILISTIC EXPOSURE ASSESSMENT FOR CHILDREN WHO CONTACT CCA-TREATED PLAYSETS AND DECKS USING THE STOCHASTIC HUMAN EXPOSURE AND DOSE SIMULATION (SHEDS) MODEL FOR THE WOOD PRESERVATIVE EXPOSURE SCENARIO

    EPA Science Inventory

    The U.S. Environmental Protection Agency has conducted a probabilistic exposure and dose assessment on the arsenic (As) and chromium (Cr) components of Chromated Copper Arsenate (CCA) using the Stochastic Human Exposure and Dose Simulation model for wood preservatives (SHEDS-Wood...

  2. Nanocomposite Treatment Reduces Disease and Lethality in a Murine Model of Acute Graft-versus-Host Disease and Preserves Anti-Tumor Effects

    PubMed Central

    Resende, Carolina B.; De Paula, Talles P.; Reis, Alesandra C.; Gonçalves, William A.; Vieira, Elias G.; Pinheiro, Maurício V. B.; Souza, Danielle G.; Castor, Marina G. M.; Teixeira, Mauro M.; Pinho, Vanessa

    2015-01-01

    Graft versus host disease (GVHD) is an immunological disorder triggered by bone marrow transplantation that affects several organs, including the gastrointestinal tract and liver. Fullerenes and their soluble forms, fullerols, are nanocomposites with a closed symmetrical structure with anti-inflammatory and anti-oxidant properties. The present study evaluated the effects of treatment with the fullerol (C60(OH)18-20) in the development and pathogenesis of GVHD in a murine model. Mice with experimental GVHD that were treated with the fullerol showed reduced clinical signs of disease and mortality compared with untreated mice. Treatment with the fullerol decreased the hepatic damage associated with reduced hepatic levels of reactive oxygen species, pro-inflammatory cytokines and chemokines (IFN-γ TNF-α, CCL2, CCL3 and CCL5) and reduced leukocyte accumulation. The amelioration of GVHD after treatment with the fullerol was also associated with reduced intestinal lesions and consequent bacterial translocation to the blood, liver and peritoneal cavity. Moreover, the fullerol treatment alleviated the GVHD while preserving effects of the graft against a leukemia cell line (GFP+P815). In summary, the fullerol was effective in reducing the GVHD inflammatory response in mice and may suggest novel ways to treat this disease. PMID:25875016

  3. Abnormal calcium homeostasis in heart failure with preserved ejection fraction is related to both reduced contractile function and incomplete relaxation: an electromechanically detailed biophysical modeling study

    PubMed Central

    Adeniran, Ismail; MacIver, David H.; Hancox, Jules C.; Zhang, Henggui

    2015-01-01

    Heart failure with preserved ejection fraction (HFpEF) accounts for about 50% of heart failure cases. It has features of incomplete relaxation and increased stiffness of the left ventricle. Studies from clinical electrophysiology and animal experiments have found that HFpEF is associated with impaired calcium homeostasis, ion channel remodeling and concentric left ventricle hypertrophy (LVH). However, it is still unclear how the abnormal calcium homeostasis, ion channel and structural remodeling affect the electro-mechanical dynamics of the ventricles. In this study we have developed multiscale models of the human left ventricle from single cells to the 3D organ, which take into consideration HFpEF-induced changes in calcium handling, ion channel remodeling and concentric LVH. Our simulation results suggest that at the cellular level, HFpEF reduces the systolic calcium level resulting in a reduced systolic contractile force, but elevates the diastolic calcium level resulting in an abnormal residual diastolic force. In our simulations, these abnormal electro-mechanical features of the ventricular cells became more pronounced with the increase of the heart rate. However, at the 3D organ level, the ejection fraction of the left ventricle was maintained due to the concentric LVH. The simulation results of this study mirror clinically observed features of HFpEF and provide new insights toward the understanding of the cellular bases of impaired cardiac electromechanical functions in heart failure. PMID:25852567

  4. Intracerebroventricular gene therapy that delays neurological disease progression is associated with selective preservation of retinal ganglion cells in a canine model of CLN2 disease.

    PubMed

    Whiting, Rebecca E H; Jensen, Cheryl A; Pearce, Jacqueline W; Gillespie, Lauren E; Bristow, Daniel E; Katz, Martin L

    2016-05-01

    CLN2 disease is one of a group of lysosomal storage disorders called the neuronal ceroid lipofuscinoses (NCLs). The disease results from mutations in the TPP1 gene that cause an insufficiency or complete lack of the soluble lysosomal enzyme tripeptidyl peptidase-1 (TPP1). TPP1 is involved in lysosomal protein degradation, and lack of this enzyme results in the accumulation of protein-rich autofluorescent lysosomal storage bodies in numerous cell types including neurons throughout the central nervous system and the retina. CLN2 disease is characterized primarily by progressive loss of neurological functions and vision as well as generalized neurodegeneration and retinal degeneration. In children the progressive loss of neurological functions typically results in death by the early teenage years. A Dachshund model of CLN2 disease with a null mutation in TPP1 closely recapitulates the human disorder with a progression from disease onset at approximately 4 months of age to end-stage at 10-11 months. Delivery of functional TPP1 to the cerebrospinal fluid (CSF), either by periodic infusion of the recombinant protein or by a single administration of a TPP1 gene therapy vector to the CSF, significantly delays the onset and progression of neurological signs and prolongs life span but does not prevent the loss of vision or modest retinal degeneration that occurs by 11 months of age. In this study we found that in dogs that received the CSF gene therapy treatment, the degeneration of the retina and loss of retinal function continued to progress during the prolonged life spans of the treated dogs. Eventually the normal cell layers of the retina almost completely disappeared. An exception was the ganglion cell layer. In affected dogs that received TPP1 gene therapy to the CSF and survived an average of 80 weeks, ganglion cell axons were present in numbers comparable to those of normal Dachshunds of similar age. The selective preservation of the retinal ganglion cells suggests

  5. Intracerebroventricular gene therapy that delays neurological disease progression is associated with selective preservation of retinal ganglion cells in a canine model of CLN2 disease

    PubMed Central

    Whiting, Rebecca E.H.; Jensen, Cheryl A.; Pearce, Jacqueline W.; Gillespie, Lauren E.; Bristow, Daniel E.; Katz, Martin L.

    2016-01-01

    CLN2 disease is one of a group of lysosomal storage disorders called the neuronal ceroid lipofuscinoses (NCLs). The disease results from mutations in the TPP1 gene that cause an insufficiency or complete lack of the soluble lysosomal enzyme tripeptidyl peptidase-1 (TPP1). TPP1 is involved in lysosomal protein degradation, and lack of this enzyme results in the accumulation of protein-rich autofluorescent lysosomal storage bodies in numerous cell types including neurons throughout the central nervous system and the retina. CLN2 disease is characterized primarily by progressive loss of neurological functions and vision as well as generalized neurodegeneration and retinal degeneration. In children the progressive loss of neurological functions typically results in death by the early teenage years. A Dachshund model of CLN2 disease with a null mutation in TPP1 closely recapitulates the human disorder with a progression from disease onset at approximately 4 months of age to end-stage at 10–11 months. Delivery of functional TPP1 to the cerebrospinal fluid (CSF), either by periodic infusion of the recombinant protein or by a single administration of a TPP1 gene therapy vector to the CSF, significantly delays the onset and progression of neurological signs and prolongs life span but does not prevent the loss of vision or modest retinal degeneration that occurs by 11 months of age. In this study we found that in dogs that received the CSF gene therapy treatment, the degeneration of the retina and loss of retinal function continued to progress during the prolonged life spans of the treated dogs. Eventually the normal cell layers of the retina almost completely disappeared. An exception was the ganglion cell layer. In affected dogs that received TPP1 gene therapy to the CSF and survived an average of 80 weeks, ganglion cell axons were present in numbers comparable to those of normal Dachshunds of similar age. The selective preservation of the retinal ganglion cells suggests

  6. Newbery Medal Acceptance.

    ERIC Educational Resources Information Center

    Freedman, Russell

    1988-01-01

    Presents the Newbery Medal acceptance speech of Russell Freedman, writer of children's nonfiction. Discusses the place of nonfiction in the world of children's literature, the evolution of children's biographies, and the author's work on "Lincoln." (ARH)

  7. Newbery Medal Acceptance.

    ERIC Educational Resources Information Center

    Cleary, Beverly

    1984-01-01

    Reprints the text of Ms. Cleary's Newbery medal acceptance speech in which she gives personal history concerning her development as a writer and her response to the letters she receives from children. (CRH)

  8. Caldecott Medal Acceptance.

    ERIC Educational Resources Information Center

    Provensen, Alice; Provensen, Martin

    1984-01-01

    Reprints the text of the Provensens' Caldecott medal acceptance speech in which they describe their early interest in libraries and literature, the collaborative aspect of their work, and their current interest in aviation. (CRH)

  9. Development of an Integrated Model for the Assessment of Climate Change Adaptation Methods Relating to the Preservation of Urban Coastal Cultural Heritage

    NASA Astrophysics Data System (ADS)

    Curran, B. R.; Routhier, M.; Mulukutla, G. K.; Gopalakrishnan, G.

    2010-12-01

    The Government Accountability Office’s report, Climate Change Adaption, examines federal, state, local, and international mitigation actions for climate change and sea-level rise. The report specifically addresses the dearth of Site-Specific Information relating to the effects of climate change on a localized scale and the challenges this poses for the development of adaption strategies. We are developing a model that will begin to regionalize climate change projections for the purpose of projecting the effects of climate change on coastal cultural heritage. As global sea level increases, so too will the number of historically significant landscapes that are threatened due to sea-level rise. Because of this, historical preservationists will require a greater availability of pertinent information in order to contend with the threats posed by climate change and rising sea levels. These threats will have a far greater impact on Low Elevation Coastal Zones (LECZ) areas. The US ranks third for land mass classified as LECZ and has an estimated population of 22 million people living within these regions. Many of these areas have had high population densities due to the concentration of marine fishery resources, ease of transportation, and agricultural associations with river deltas. These areas have acted as catalysts for the evolution of various societies and cultures, and contain a concentrated stratification of cultural heritage deposits. The development of models for the assessment of spatial/temporal impacts of climate change on coastal cultural heritage will play a significant role in defining long-term preservation needs on a regional scale. We are coordinating ground water seepage models, tidal estuary models, and the regionalized Global Climate Models with localized geophysical assessments and GIS data sets. Through the digitization and rectification of various contemporary and historical maps we have developed a GIS data set that reflects the evolution of the

  10. A History Worth Preserving

    NASA Astrophysics Data System (ADS)

    Kelly, Cynthia

    2008-04-01

    The Manhattan Project transformed the course of American and world history, science, politics and society. If we can read about this in books and watch History Channel documentaries, why do we need to preserve some of the properties of this enormous undertaking? The presentation, ``A History Worth Preserving,'' will address why some of the physical properties need to be preserved and which ones we are struggling to maintain for future generations. The story of this effort begins in 1997 as the Department of Energy was posed to demolish the last remaining Manhattan Project properties at the Los Alamos laboratory. Located deep behind security fences, the ``V Site's'' asbestos-shingled wooden buildings looked like humble garages with over-sized wooden doors. The ``V Site'' properties were almost lost twice, first to bulldozers and then the Cerro Grande fire of 2000. Now, visitors can stand inside the building where J. Robert Oppenheimer and his crew once worked and imagine the Trinity ``gadget'' hanging from its hoist shortly before it ushered in the Atomic Age on July 16, 1945. As Richard Rhodes has commented, we preserve what we value of the physical past because it specifically embodies our social past. But many challenge whether the Manhattan Project properties ought to be preserved. Rather than recognize the Manhattan Project as a great achievement worthy of commemoration, some see it as a regrettable event, producing an instrument to take man's inhumanity to man to extremes. While these divergent views will no doubt persist, the significance of the Manhattan Project in producing the world's first atomic bombs is irrefutable. Preserving some of its tangible remains is essential so that future generations can understand what the undertaking entailed from its humble wooden sheds to enormous first-of-a-kind industrial plants with 125,000 people working in secret and living in frontier-like communities. With continuing pressure for their demolition, what progress has

  11. Privacy Preserving Nearest Neighbor Search

    NASA Astrophysics Data System (ADS)

    Shaneck, Mark; Kim, Yongdae; Kumar, Vipin

    Data mining is frequently obstructed by privacy concerns. In many cases data is distributed, and bringing the data together in one place for analysis is not possible due to privacy laws (e.g. HIPAA) or policies. Privacy preserving data mining techniques have been developed to address this issue by providing mechanisms to mine the data while giving certain privacy guarantees. In this chapter we address the issue of privacy preserving nearest neighbor search, which forms the kernel of many data mining applications. To this end, we present a novel algorithm based on secure multiparty computation primitives to compute the nearest neighbors of records in horizontally distributed data. We show how this algorithm can be used in three important data mining algorithms, namely LOF outlier detection, SNN clustering, and kNN classification. We prove the security of these algorithms under the semi-honest adversarial model, and describe methods that can be used to optimize their performance. Keywords: Privacy Preserving Data Mining, Nearest Neighbor Search, Outlier Detection, Clustering, Classification, Secure Multiparty Computation

  12. The ZEUS data preservation project

    NASA Astrophysics Data System (ADS)

    Malka, Janusz; Wichmann, Katarzyna

    2012-12-01

    A project to allow long term access and physics analysis of ZEUS data (ZEUS data preservation) has been established in collaboration with the DESY-IT group. In the ZEUS approach the analysis model is based on the Common Ntuple project, under development since 2006. The real data and all presently available Monte Carlo samples are being preserved in a flat ROOT ntuple format. There is ongoing work to provide the ability to simulate new, additional Monte Carlo samples also in the future. The validation framework of such a scheme using virtualisation techniques is being explored. The goal is to validate the frozen ZEUS software against future changes in hardware and operating system. A cooperation between ZEUS, DESY-IT and the library was established for document digitisation and long-term preservation of collaboration web pages. Part of the ZEUS internal documentation has already been stored within the HEP documentation system INSPIRE. Existing digital documentation, needed to perform physics analysis also in the future, is being centralised and completed.

  13. Dual A1/A2B Receptor Blockade Improves Cardiac and Renal Outcomes in a Rat Model of Heart Failure with Preserved Ejection Fraction.

    PubMed

    Tofovic, Stevan P; Salah, Eman M; Smits, Glenn J; Whalley, Eric T; Ticho, Barry; Deykin, Aaron; Jackson, Edwin K

    2016-02-01

    Heart failure with preserved ejection fraction (HFpEF) is prevalent and often accompanied by metabolic syndrome. Current treatment options are limited. Here, we test the hypothesis that combined A1/A2B adenosine receptor blockade is beneficial in obese ZSF1 rats, an animal model of HFpEF with metabolic syndrome. The combined A1/A2B receptor antagonist 3-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)-1-bicyclo[2.2.2]octanyl]propanoic acid (BG9928) was administered orally (10 mg/kg/day) to obese ZSF1 rats (n = 10) for 24 weeks (from 20 to 44 weeks of age). Untreated ZSF1 rats (n = 9) served as controls. After 24 weeks of administration, BG9928 significantly lowered plasma triglycerides (in mg/dl: control group, 4351 ± 550; BG9928 group, 2900 ± 551) without adversely affecting plasma cholesterol or activating renin release. BG9928 significantly decreased 24-hour urinary glucose excretion (in mg/kg/day: control group, 823 ± 179; BG9928 group, 196 ± 80) and improved oral glucose tolerance, polydipsia, and polyuria. BG9928 significantly augmented left ventricular diastolic function in association with a reduction in cardiac vasculitis and cardiac necrosis. BG9928 significantly reduced 24-hour urinary protein excretion (in mg/kg/day: control group, 1702 ± 263; BG9928 group, 1076 ± 238), and this was associated with a reduction in focal segmental glomerulosclerosis, tubular atrophy, tubular dilation, and deposition of proteinaceous material in the tubules. These findings show that, in a model of HFpEF with metabolic syndrome, A1/A2B receptor inhibition improves hyperlipidemia, exerts antidiabetic actions, reduces HFpEF, improves cardiac histopathology, and affords renal protection. We conclude that chronic administration of combined A1/A2B receptor antagonists could be beneficial in patients with HFpEF, in particular those with comorbidities such as obesity, diabetes, and dyslipidemias. PMID:26585572

  14. A mouse model of heart failure with preserved ejection fraction due to chronic infusion of a low subpressor dose of angiotensin II

    PubMed Central

    Regan, Jessica A.; Mauro, Adolfo Gabriele; Carbone, Salvatore; Marchetti, Carlo; Gill, Rabia; Mezzaroma, Eleonora; Valle Raleigh, Juan; Salloum, Fadi N.; Van Tassell, Benjamin W.; Abbate, Antonio

    2015-01-01

    Heart failure (HF) with preserved ejection fraction (HFpEF) is a clinical syndrome of HF symptoms associated with impaired diastolic function. Although it represents ∼50% of patients with HF, the mechanisms of disease are poorly understood, and therapies are generally ineffective in reducing HF progression. Animal models of HFpEF not due to pressure or volume overload are lacking, therefore limiting in-depth understanding of the pathophysiological mechanisms and the development of novel therapies. We hypothesize that a continuous infusion of low-dose angiotensin II (ATII) is sufficient to induce left ventricular (LV) diastolic dysfunction and HFpEF, without increasing blood pressure or inducing LV hypertrophy or dilatation. Osmotic pumps were implanted subcutaneously in 8-wk-old male mice assigned to the ATII (0.2 mg·kg−1·day−1) or volume-matched vehicle (N = 8/group) for 4 wk. We measured systolic and diastolic arterial blood pressures through a tail-cuff transducer, LV dimensions and ejection fraction through echocardiography, and LV relaxation through pulsed-wave Doppler and LV catheterization. Myocardial fibrosis and cardiomyocyte cross-sectional area were measured. ATII infusion had no effects on systemic arterial blood pressure. ATII induced significant impairment in LV diastolic function, as measured by an increase (worsening) in LV isovolumetric relaxation time, myocardial performance index, isovolumetric relaxation time constant, and LV end-diastolic pressure without altering LV dimensions, mass, or ejection fraction. Chronic infusion of low-dose ATII recapitulates the HFpEF phenotype in the mouse, without increasing systemic arterial blood pressure. This mouse model may provide insight into the mechanisms of HFpEF. PMID:26188021

  15. A mouse model of heart failure with preserved ejection fraction due to chronic infusion of a low subpressor dose of angiotensin II.

    PubMed

    Regan, Jessica A; Mauro, Adolfo Gabriele; Carbone, Salvatore; Marchetti, Carlo; Gill, Rabia; Mezzaroma, Eleonora; Valle Raleigh, Juan; Salloum, Fadi N; Van Tassell, Benjamin W; Abbate, Antonio; Toldo, Stefano

    2015-09-01

    Heart failure (HF) with preserved ejection fraction (HFpEF) is a clinical syndrome of HF symptoms associated with impaired diastolic function. Although it represents ∼50% of patients with HF, the mechanisms of disease are poorly understood, and therapies are generally ineffective in reducing HF progression. Animal models of HFpEF not due to pressure or volume overload are lacking, therefore limiting in-depth understanding of the pathophysiological mechanisms and the development of novel therapies. We hypothesize that a continuous infusion of low-dose angiotensin II (ATII) is sufficient to induce left ventricular (LV) diastolic dysfunction and HFpEF, without increasing blood pressure or inducing LV hypertrophy or dilatation. Osmotic pumps were implanted subcutaneously in 8-wk-old male mice assigned to the ATII (0.2 mg·kg(-1)·day(-1)) or volume-matched vehicle (N = 8/group) for 4 wk. We measured systolic and diastolic arterial blood pressures through a tail-cuff transducer, LV dimensions and ejection fraction through echocardiography, and LV relaxation through pulsed-wave Doppler and LV catheterization. Myocardial fibrosis and cardiomyocyte cross-sectional area were measured. ATII infusion had no effects on systemic arterial blood pressure. ATII induced significant impairment in LV diastolic function, as measured by an increase (worsening) in LV isovolumetric relaxation time, myocardial performance index, isovolumetric relaxation time constant, and LV end-diastolic pressure without altering LV dimensions, mass, or ejection fraction. Chronic infusion of low-dose ATII recapitulates the HFpEF phenotype in the mouse, without increasing systemic arterial blood pressure. This mouse model may provide insight into the mechanisms of HFpEF. PMID:26188021

  16. High-intensity interval training attenuates endothelial dysfunction in a Dahl salt-sensitive rat model of heart failure with preserved ejection fraction.

    PubMed

    Adams, Volker; Alves, Marcia; Fischer, Tina; Rolim, Natale; Werner, Sarah; Schütt, Nicole; Bowen, T Scott; Linke, Axel; Schuler, Gerhard; Wisloff, Ulrik

    2015-09-15

    Heart failure patients with preserved left ventricular ejection fraction (HFpEF) have endothelial dysfunction, but the underlying molecular mechanisms remain unknown. In addition, whether exercise training improves endothelial function in HFpEF is still controversial. The present study therefore aimed to determine the functional and molecular alterations in the endothelium associated with HFpEF, while further assessing the effects of high-intensity interval training (HIT). Female Dahl salt-sensitive rats were randomized for 28 wk into the following groups: 1) control: fed 0.3% NaCl; 2) HFpEF: fed 8% NaCl; and 3) HFpEF + HIT: animals fed 8% NaCl and HIT treadmill exercise. Echocardiography and invasive hemodynamic measurements were used to assess diastolic dysfunction. Endothelial function of the aorta was measured in vitro. Expression of endothelial nitric oxide synthase (eNOS), nicotinamide adenine dinucleotide phosphate-oxidase [NAD(P)H oxidase], and advanced glycation end product (AGE)-modified proteins were quantified by Western blot, and zymography quantified matrix metalloproteinase (MMP) activity. In this model of HFpEF, endothelium-dependent and -independent vasodilation was impaired. However, this was prevented by HIT. In HFpEF protein expression of eNOS was reduced by 47%, but MMP-2 and MMP-9 activity was elevated by 186 and 68%. The expression of AGE-modified proteins was increased by 106%. All of these changes were prevented by HIT. Endothelial function was impaired in this model of HFpEF, which was associated with reduced expression of eNOS, increased MMP activity, and increased AGE-modified proteins. HIT was able to attenuate both these functional and molecular alterations. These findings therefore suggest HFpEF induces endothelial dysfunction, but this is reversible by HIT. PMID:26229002

  17. Tablet Personal Computer Integration in Higher Education: Applying the Unified Theory of Acceptance and Use Technology Model to Understand Supporting Factors

    ERIC Educational Resources Information Center

    Moran, Mark; Hawkes, Mark; El Gayar, Omar

    2010-01-01

    Many educational institutions have implemented ubiquitous or required laptop, notebook, or tablet personal computing programs for their students. Yet, limited evidence exists to validate integration and acceptance of the technology among student populations. This research examines student acceptance of mobile computing devices using a modification…

  18. Preservation and transplantation of porcine testis tissue.

    PubMed

    Zeng, W; Snedaker, A K; Megee, S; Rathi, R; Chen, F; Honaramooz, A; Dobrinski, I

    2009-01-01

    Grafting of immature mammalian testis tissue to mouse hosts can preserve the male germline. To make this approach applicable to a clinical or field situation, it is imperative that the testis tissue and/or spermatozoa harvested from grafted tissue are preserved successfully. The aim of the present study was to evaluate protocols for the preservation of testis tissue in a porcine model. Testis tissue was stored at 4 degrees C for short-term preservation or cryopreserved by slow-freezing, automated slow-freezing or vitrification for long-term storage. Preserved tissue was transplanted ectopically to mouse hosts and recovered xenografts were analysed histologically. In addition, spermatozoa were harvested from xenografts and cryopreserved. Total cell viability and germ cell viability remained high after tissue preservation. Complete spermatogenesis occurred in xenografts preserved by cooling up to 48 h, whereas spermatogenesis progressed to round spermatids in the xenografts that were frozen-thawed before grafting. Approximately 50% of spermatozoa harvested from xenografts remained viable after freezing and thawing. The in vivo developmental potential of cryopreserved tissue was reduced despite high post-thaw viability. Therefore, it is important to evaluate germ cell differentiation in vivo in addition to cell viability in vitro when optimising freezing protocols for testis tissue. PMID:19261226

  19. Family Preservation & Family Functioning.

    ERIC Educational Resources Information Center

    McCroskey, Jacquelyn; Meezan, William

    This book reports a study of the outcomes of home-based family preservation services for abusive and neglectful families in Los Angeles County. Using the Family Assessment Form, the research project evaluated services provided by two voluntary agencies, and focused on changes in family functioning between the opening and closing of services during…

  20. Preserving Southwest Virginia's Folklore.

    ERIC Educational Resources Information Center

    Burgin, Ramond

    1997-01-01

    Describes Southwest Virginia's rich tradition of folklore and culture and the need for its preservation. Summarizes the author's time-consuming process of preparing an inventory and indexing the vast archival collections gathered by students in American Folklore classes at Mountain Empire Community College and by the Southwest Virginia Folklore…

  1. Paints and Preservatives.

    ERIC Educational Resources Information Center

    Powell, Larry E.; Miller, Larry E.

    The publication contains an outline for use by agriculture teachers in developing a teaching plan for a unit on paints and preservatives. The topics included are (1) recognizing, solving, and preventing paint problems and (2) operating and using power spray painting equipment. Items presented for each topic are: the situation, (intended to inform…

  2. Preserving the Seminar Experience

    ERIC Educational Resources Information Center

    Ramsey, David; Evans, Jocelyn; Levy, Meyer

    2016-01-01

    This article presents a new approach to online graduate education. With hopes of recruiting a larger cohort in order to preserve a graduate program struggling with low enrollment, we began offering a limited number of seats to students who would attend class in real time but from remote locations, using a videoconferencing platform. Unlike…

  3. Improving Acceptance of Automated Counseling Procedures.

    ERIC Educational Resources Information Center

    Johnson, James H.; And Others

    This paper discusses factors that may influence the acceptance of automated counseling procedures by the military. A consensual model of the change process is presented which structures organizational readiness, the change strategy, and acceptance as integrated variables to be considered in a successful installation. A basic introduction to the…

  4. A survey of university students' perceptions of learning management systems in a low-resource setting using a technology acceptance model.

    PubMed

    Chipps, Jennifer; Kerr, Jane; Brysiewicz, Petra; Walters, Fiona

    2015-02-01

    Learning management systems have been widely advocated for the support of distance learning. In low-resource settings, the uptake of these systems by students has been mixed. This study aimed to identify, through the use of the Technology Acceptance Model, the individual, organizational, and technological factors that could be influencing the use of learning management systems. A simple quantitative descriptive survey was conducted of nursing and health science students at a university in South Africa as part of their first exposure to a learning management system. A total of 274 respondents (56.7%) completed the survey questionnaire, made up of 213 nursing respondents (87.7%) and 61 health sciences respondents (25%). Overall, the respondents found the learning management system easy to use and useful for learning. There were significant differences between the two groups of respondents, with the respondents from health sciences being both younger and more computer literate. The nursing respondents, who received more support and orientations, reported finding the learning management system more useful. Recommendations are made for training and support to ensure uptake. PMID:25521789

  5. Damage to pancreatic acinar cells and preservation of islets of Langerhans in a rat model of acute pancreatitis induced by Karwinskia humboldtiana (buckthorn).

    PubMed

    Carcano-Diaz, Katya; Garcia-Garcia, Aracely; Segoviano-Ramirez, Juan Carlos; Rodriguez-Rocha, Humberto; Loera-Arias, Maria de Jesus; Garcia-Juarez, Jaime

    2016-09-01

    Karwinskia humboldtiana (Kh) is a poisonous plant that grows in some regions of the American continent. Consuming large amounts of Kh fruit results in acute intoxication leading to respiratory failure, culminating in death within days. There is evidence of histological damage to the lungs, liver, and kidneys following accidental and experimental Kh intoxication. To date, the microscopic effect of Kh consumption on the pancreas has not been described. We examined the early effects of Kh fruit on pancreatic tissue at different stages of acute intoxication in the Wistar rat. We found progressive damage confined to the exocrine pancreas, starting with a reduction in the number of zymogen granules, loss of acinar architecture, the presence of autophagy-like vesicles, apoptosis and inflammatory infiltrate. The pancreatic pathology culminated in damaged acini characterized by necrosis and edema, with a complete loss of lobular architecture. Interestingly, the morphology of the islets of Langerhans was conserved throughout our evaluations. Taken together, our results indicate the damage induced by a high dose of Kh fruit in the Wistar rat is consistent with an early acute necrotizing pancreatitis that exclusively affects the exocrine pancreas. Therefore, this system might be useful as an animal model to study the treatment of pancreatic diseases. More importantly, as the islets of Langerhans were preserved, the active compounds of Kh fruit could be utilized for the treatment of acinar pancreatic cancer. Further studies might provide insight into the severity of acute Kh intoxication in humans and influence the design of treatments for pancreatic diseases and acinar pancreatic cancer. PMID:26877198

  6. Development of Models To Relate Microbiological and Headspace Volatile Parameters in Stored Atlantic Salmon to Acceptance and Willingness To Prepare the Product by Senior Consumers.

    PubMed

    Erickson, Marilyn C; Ma, Li M; Doyle, Michael P

    2015-12-01

    Microbial spoilage of salmon occurs during extended refrigerated storage and is often accompanied by unpleasant aromas. When spoilage is detected, it is assumed that consumers will reject the product for consumption. Because sensory panels of trained individuals or consumers are expensive and labor intensive, identification of microbiological or chemical indicators to characterize the extent to which fish has spoiled is needed when experimental process and storage treatments are being evaluated. A consumer panel of 53 senior citizens (60 to 85 years of age) evaluated in duplicate raw salmon subjected to 10 storage conditions, and the fish quality was targeted to range from fresh to very spoiled. This population group was chosen because they would be expected to have a greater prevalence of olfactory impairments and higher odor thresholds than the general population; in turn, a shorter safety margin or time period between product rejection due to spoilage and the generation of Clostridium botulinum toxins would be likely. Low hedonic scores for aroma and overall acceptance (2 or 3 of 9), corresponding to "dislike very much" to "dislike moderately," did not equate with unwillingness to prepare the sample for consumption by up to seven panelists (13%) when the product was presumed to have already been purchased. Despite these outliers, significant models (P = 0.0000) were developed for the willingness of consumers to prepare the sample for consumption and the sample's aerobic and anaerobic microbiological populations and two volatile peaks with Kovats indices of 640 and 753. However, these models revealed that the levels of microbiological and chemical markers must be very high before some consumers would reject the sample; hence, spoilage detection by smell would likely not be an adequate safeguard against consuming salmon in which C. botulinum toxin had been generated. PMID:26613910

  7. Enterocins in food preservation.

    PubMed

    Khan, Haider; Flint, Steve; Yu, Pak-Lam

    2010-06-30

    The Enterococcus genus, a member of the Lactic Acid Bacteria (LAB) is found in various environments, but more particularly in the intestines of humans and other animals. Although sometimes associated with pathogenicity these bacteria have many benefits. They have been found in traditional artisanal fermented products, are used as probiotic cultures and nowadays extensively studied for the production of bacteriocins--the enterocins. Many of these enterocins have been found to be active against Listeria monocytogenes, and a few have also been reported to be active even against Gram negative bacteria, an unusual property for the bacteriocins produced by LAB. These properties have resulted in many studies describing the use of enterocins as preservatives in foods of animal and vegetable origin. This review covers the most recent information on the use of enterocins as food preservatives, either produced in-situ by the addition of enterocin producing strains or as external preservatives in the form of purified or semi-purified extracts, to prevent the growth of spoilage and pathogenic microorganisms. PMID:20399522

  8. Accept or divert?

    PubMed

    Angelucci, P A

    1999-09-01

    Stretching scarce resources is more than a managerial issue. Should you accept the patient to an understaffed ICU or divert him to another facility? The intense "medical utility" controversy focuses on a situation that critical care nurses now face every day. PMID:10614370

  9. Approaches to acceptable risk

    SciTech Connect

    Whipple, C.

    1997-04-30

    Several alternative approaches to address the question {open_quotes}How safe is safe enough?{close_quotes} are reviewed and an attempt is made to apply the reasoning behind these approaches to the issue of acceptability of radiation exposures received in space. The approaches to the issue of the acceptability of technological risk described here are primarily analytical, and are drawn from examples in the management of environmental health risks. These include risk-based approaches, in which specific quantitative risk targets determine the acceptability of an activity, and cost-benefit and decision analysis, which generally focus on the estimation and evaluation of risks, benefits and costs, in a framework that balances these factors against each other. These analytical methods tend by their quantitative nature to emphasize the magnitude of risks, costs and alternatives, and to downplay other factors, especially those that are not easily expressed in quantitative terms, that affect acceptance or rejection of risk. Such other factors include the issues of risk perceptions and how and by whom risk decisions are made.

  10. 1984 Newbery Acceptance Speech.

    ERIC Educational Resources Information Center

    Cleary, Beverly

    1984-01-01

    This acceptance speech for an award honoring "Dear Mr. Henshaw," a book about feelings of a lonely child of divorce intended for eight-, nine-, and ten-year-olds, highlights children's letters to author. Changes in society that affect children, the inception of "Dear Mr. Henshaw," and children's reactions to books are highlighted. (EJS)

  11. Why was Relativity Accepted?

    NASA Astrophysics Data System (ADS)

    Brush, S. G.

    Historians of science have published many studies of the reception of Einstein's special and general theories of relativity. Based on a review of these studies, and my own research on the role of the light-bending prediction in the reception of general relativity, I discuss the role of three kinds of reasons for accepting relativity (1) empirical predictions and explanations; (2) social-psychological factors; and (3) aesthetic-mathematical factors. According to the historical studies, acceptance was a three-stage process. First, a few leading scientists adopted the special theory for aesthetic-mathematical reasons. In the second stage, their enthusiastic advocacy persuaded other scientists to work on the theory and apply it to problems currently of interest in atomic physics. The special theory was accepted by many German physicists by 1910 and had begun to attract some interest in other countries. In the third stage, the confirmation of Einstein's light-bending prediction attracted much public attention and forced all physicists to take the general theory of relativity seriously. In addition to light-bending, the explanation of the advance of Mercury's perihelion was considered strong evidence by theoretical physicists. The American astronomers who conducted successful tests of general relativity became defenders of the theory. There is little evidence that relativity was `socially constructed' but its initial acceptance was facilitated by the prestige and resources of its advocates.

  12. Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation

    PubMed Central

    Kaths, J. Moritz; Spetzler, Vinzent N.; Goldaracena, Nicolas; Echeverri, Juan; Louis, Kristine S.; Foltys, Daniel B.; Strempel, Mari; Yip, Paul; John, Rohan; Mucsi, Istvan; Ghanekar, Anand; Bagli, Darius; Robinson, Lisa; Selzner, Markus

    2015-01-01

    Kidney transplantation has become a well-established treatment option for patients with end-stage renal failure. The persisting organ shortage remains a serious problem. Therefore, the acceptance criteria for organ donors have been extended leading to the usage of marginal kidney grafts. These marginal organs tolerate cold storage poorly resulting in increased preservation injury and higher rates of delayed graft function. To overcome the limitations of cold storage, extensive research is focused on alternative normothermic preservation methods. Ex vivo normothermic organ perfusion is an innovative preservation technique. The first experimental and clinical trials for ex vivo lung, liver, and kidney perfusions demonstrated favorable outcomes. In addition to the reduction of cold ischemic injury, the method of normothermic kidney storage offers the opportunity for organ assessment and repair. This manuscript provides information about kidney retrieval, organ preservation techniques, and isolated ex vivo normothermic kidney perfusion (NEVKP) in a porcine model. Surgical techniques, set up for the perfusion solution and the circuit, potential assessment options, and representative results are demonstrated. PMID:26275014

  13. Preserving a Lunar Legacy

    NASA Astrophysics Data System (ADS)

    O'Leary, B.; Brown, L. F.; Gibson, R. A.; Versluis, J.

    2000-12-01

    With the first Russian flyby mission in 1959, the quest for robotic, and eventually, manned exploration of the moon became fact rather than fiction. Since then there have been innumerable spacecraft impacts and landers which have left artifacts and created archaeological sites on the lunar surface. One of the most significant events in lunar exploration came with the successful landing of the manned Apollo 11 mission in the Sea of Tranquillity (July 20, 1969). Missions such as these form a transcript of the world's quest to explore space and are evidence of humanity's first steps in this ultimate journey. One would think that, given the historic nature of these endeavors, some process would have been established to preserve sites for future generations. There is certainly little disagreement within the astronomical and archeological communities that lunar landing and impact sites are precious cultural resources containing irreplaceable artifacts that attest to humanity's initial efforts to explore other worlds. But, in fact, there are no federal preservation laws, nor international criteria, which directly address preservation procedures and decisions on other solar system bodies. Although the moon's remoteness and isolation have protected lunar sites to date, recent commercial interests in development, and in private robotic exploration, of the moon, make preservation of these historic sites even more timely. This preliminary study, funded in part by NASA, has begun to document the Apollo 11 landing site by making the first complete inventory of artifacts, and features, and completing an archeological site map of Tranquillity Base. We will discuss the issues in obtaining accurate lists of the cultural resources left behind, in documenting their historic context, and in the problems of selenographic mapping. Detailed information is needed to document the integrity historical importance of any location with the eventual aim of having it listed as a UNESCO World

  14. Pancreas preservation for pancreas and islet transplantation

    PubMed Central

    Iwanaga, Yasuhiro; Sutherland, David E.R.; Harmon, James V.; Papas, Klearchos K.

    2010-01-01

    Purpose of review To summarize advances and limitations in pancreas procurement and preservation for pancreas and islet transplantation, and review advances in islet protection and preservation. Recent findings Pancreases procured after cardiac death, with in-situ regional organ cooling, have been successfully used for islet transplantation. Colloid-free Celsior and histidine-tryptophan-ketoglutarate preservation solutions are comparable to University of Wisconsin solution when used for cold storage before pancreas transplantation. Colloid-free preservation solutions are inferior to University of Wisconsin solution for pancreas preservation prior to islet isolation and transplantation. Clinical reports on pancreas and islet transplants suggest that the two-layer method may not offer significant benefits over cold storage with the University of Wisconsin solution: improved oxygenation may depend on the graft size; benefits in experimental models may not translate to human organs. Improvements in islet yield and quality occurred from pancreases treated with inhibitors of stress-induced apoptosis during procurement, storage, isolation or culture. Pancreas perfusion may be desirable before islet isolation and transplantation and may improve islet yields and quality. Methods for real-time, noninvasive assessment of pancreas quality during preservation have been implemented and objective islet potency assays have been developed and validated. These innovations should contribute to objective evaluation and establishment of improved pancreas preservation and islet isolation strategies. Summary Cold storage may be adequate for preservation before pancreas transplants, but insufficient when pancreases are processed for islets or when expanded donors are used. Supplementation of cold storage solutions with cytoprotective agents and perfusion may improve pancreas and islet transplant outcomes. PMID:18685343

  15. Induced gravity from curvature density preserving diffeomorphisms

    NASA Astrophysics Data System (ADS)

    Oda, Ichiro

    2016-08-01

    We construct not only an induced gravity model with restricted diffeomorphisms, that is, transverse diffeomorphisms that preserve the curvature density, but also with full diffeomorphisms. By solving the equations of motion, it turns out that these models produce Einstein's equations with a certain Newton constant in addition to the constraint for the curvature density. In the limit of the infinite Newton constant, the models give rise to induced gravity. Moreover, we discuss cosmological solutions on the basis of the gravitational models at hand.

  16. Acceptability of human risk.

    PubMed Central

    Kasperson, R E

    1983-01-01

    This paper has three objectives: to explore the nature of the problem implicit in the term "risk acceptability," to examine the possible contributions of scientific information to risk standard-setting, and to argue that societal response is best guided by considerations of process rather than formal methods of analysis. Most technological risks are not accepted but are imposed. There is also little reason to expect consensus among individuals on their tolerance of risk. Moreover, debates about risk levels are often at base debates over the adequacy of the institutions which manage the risks. Scientific information can contribute three broad types of analyses to risk-setting deliberations: contextual analysis, equity assessment, and public preference analysis. More effective risk-setting decisions will involve attention to the process used, particularly in regard to the requirements of procedural justice and democratic responsibility. PMID:6418541

  17. Preserving the Manhattan Project

    NASA Astrophysics Data System (ADS)

    Kelly, Cynthia

    2014-03-01

    When future generations look back on the 20th century, few events will rival the harnessing of nuclear energy as a turning point in world history, science and society. Yet, the Department of Energy has not always embraced its Manhattan Project origins. The presentation will focus on the progress made over the last 20 years to preserve the properties and first-hand accounts that for decades have been threatened with demolition and indifference. Since the mid-1950s, most remaining Manhattan Project properties at the Los Alamos National Laboratory had been abandoned. Among them was a cluster of wooden buildings called the ``V Site.'' This is where scientists assembled the ``Gadget,'' the world's first atomic device tested on July 16, 1945. Regardless of its significance, the ``V Site'' buildings like all the rest were slated for demolition. The Advisory Council on Historic Preservation (ACHP) toured the properties in November 1998. Most could not believe that the world's first atomic bomb was designed in such humble structures. The properties were declared to be ``monumental in their lack of monumentality.'' A Save America's Treasures grant for 700,000 was awarded to restore the properties. To raise the required matching funds, I left the Federal government and soon founded the Atomic Heritage Foundation. The presentation will trace the progress made over the last decade to generate interest and support nationwide to preserve the Manhattan Project heritage. Saving both the physical properties and first-hand accounts of the men and women have been a priority. Perhaps our most significant achievement may be legislation now under consideration by Congress to create a Manhattan Project National Historical Park. Seventy years later, the Manhattan Project is finally getting the recognition it deserves.

  18. Age and Acceptance of Euthanasia.

    ERIC Educational Resources Information Center

    Ward, Russell A.

    1980-01-01

    Study explores relationship between age (and sex and race) and acceptance of euthanasia. Women and non-Whites were less accepting because of religiosity. Among older people less acceptance was attributable to their lesser education and greater religiosity. Results suggest that quality of life in old age affects acceptability of euthanasia. (Author)

  19. Preservation Strategies for Electronic Records: Where We Are Now--Obliquity and Squint?

    ERIC Educational Resources Information Center

    Cloonan, Michele V.; Sanett, Shelby

    2002-01-01

    Reports on an international survey of the activities of 13 institutions and projects that employ or are exploring strategies to preserve authentic electronic records. Topics include preservation techniques; selection for preservation; staffing configurations; cost modeling; access to preserved records; and policymaking. Appendices include…

  20. Development of a model describing the inhibitory effect of selected preservatives on the growth of Listeria monocytogenes in a meat model system.

    PubMed

    Dussault, Dominic; Vu, Khanh Dang; Lacroix, Monique

    2016-02-01

    The objective of this study was to evaluate the impact of seven independent factors consisting of sodium nitrite, pH, sodium chloride, sodium acetate, sodium lactate syrup, calcium propionate and a blend of nisin and hop alpha acids on the growth rate of Listeria monocytogenes in ham as a model of ready-to-eat (RTE) meat products. A central composite consisted of seven factors mentioned above was designed and the response surface methodology was applied for creating a mathematic model to predict the growth rate of L. monocytogenes in RTE meat products. Six parameters showed a significant (P ≤ 0.1) influence on the growth rate of L. monocytogenes. Only the blend of nisin and hop alpha acids did not show any significant effect (P > 0.1) in the concentrations used in this study. Increasing concentration of sodium chloride, sodium nitrite, sodium acetate, potassium lactate and calcium propionate in meat reduced bacterial growth rate while increasing pH in meat increased the growth rate of L. monocytogenes. The current mathematical equation will be an important tool in order to reduce the required number of challenge studies performed in order to ensure a safe food product. PMID:26678138

  1. Preserving Perishables (Dormavac)

    NASA Technical Reports Server (NTRS)

    1979-01-01

    A new commercial product that can preserve perishable commodities for weeks without freezing, so that they can be shipped fresh without the cost of air freight, has been developed by Grumman Corporation, Bethpage, Long Island, New York. The development benefited from the company's experience in developing the environmental control system for the Lunar Module, which delivered Apollo astronauts to the surface of the moon. Called Dormavac, the system provides a commodity-preserving environment within an aluminum container that can be transported by truck, rail or ship. Dormavac creates a cold-but above freezing-environment with high relative humidity and very low air pressure. The saturated air minimizes commodity weight loss and the air is automatically changed several times an hour to flush away odors and harmful gases released by the commodities. According to company literature, Dormavac significantly extends the transportation life of perishables. For example, pork has a normal cold storage life of about seven days, beef two weeks and tomatoes three weeks; with Dormavac, pork remains fresh for three weeks, beef more than six weeks and tomatoes seven weeks or more. Dormavac is manufactured and marketed by Grumman Allied Industries, Woodbury, New York. In developing the system, Grumman Allied drew upon the technological resources of another company subsidiary, Grumman Aerospace. Engineers who had earlier worked on Lunar Module environmental control brought their know-how and experience to the Dormavac development.

  2. Oversize Color Images Project, 1994-1995. A Report to the Commission on Preservation and Access.

    ERIC Educational Resources Information Center

    Gertz, Janet

    This report provides results of the first phase of a project to identify acceptable preservation and digital access techniques for dealing with oversize, color images associated with text. The goal of Phase I was to provide a preservation-quality photographic archival copy, a digital version for online access, and paper printouts. Five maps from…

  3. The stratified microbial community at Laguna Figueroa, Baja California, Mexico: a possible model for prephanerozoic laminated microbial communities preserved in cherts.

    PubMed

    Stolz, J F; Margulis, L

    1984-01-01

    The microbial mat community of the evaporite flat at North Pond, Laguna Figueroa (Baja California, Mexico) was actively involved in the production of laminated sediments prior to 1978. Heavy rains in 1979 and 1980 flooded the mat with 1 and 3 meters of meteoric water respectively. The flooding deposited up to 10 cm of silicoclastic sediment over the Microcoleus-dominated mat and resulted in the cessation of laminated sediment deposition. In 1982, the surface had been recolonized by species of cyanobacteria (Spirulina, Oscillatoria) and purple photosynthetic bacteria (Chromatium, Thiocapsa). The silicoclastic sediments and residual evaporites, which overlaid the laminated sediment, had been reworked into an anaerobic, sulfide-rich mud and contained well preserved sheaths of filamentous and coccoid bacteria. The Swaziland Sequence in the Barberton mountain land (which includes the Onverwacht and Fig Tree Group as well as the Swartkoppie zone between them) contains laminated sediments and carbon-rich chert. Structurally preserved microfossils have been found in the smooth black chert but not in the laminae. We concur with others who suggested that the laminated sediments from the Swaziland Sequence were deposited by an active stratified microbial community. However, we propose that these organisms which were preserved were originally buried in the associated sulfide-rich muds and were subsequently silicified. PMID:11536585

  4. A Model for Beliefs, Tool Acceptance Levels and Web Pedagogical Content Knowledge of Science and Technology Preservice Teachers towards Web Based Instruction

    ERIC Educational Resources Information Center

    Horzum, Mehmet Baris; Canan Gungoren, Ozlem

    2012-01-01

    One of the applications applied most nowadays is web based instruction (WBI). Although there are many studies on WBI, no study which researched the relations between beliefs for WBI, WBI tools acceptance levels and web pedagogical content knowledge (WPCK) of science and technology pre-service teachers was found among these studies. The aim of this…

  5. Technology Acceptance in an Academic Context: Faculty Acceptance of Online Education

    ERIC Educational Resources Information Center

    Gibson, Shanan G.; Harris, Michael L.; Colaric, Susan M.

    2008-01-01

    The authors surveyed faculty from a college of business and a college of education regarding their attitudes toward online education. Results of the survey were examined to determine the degree to which the technology acceptance model was able to adequately explain faculty acceptance of online education. Results indicate that perceived usefulness…

  6. Conception et validation d'un modele d'analyse et de suivi pour une politique energetique durable et acceptable de l'energie eolienne: Une etude comparative France-Quebec

    NASA Astrophysics Data System (ADS)

    Feurtey, Evariste

    In this research, we built a conceptual model of a sustainable and acceptable wind power policy that we tried to validate through the case study of France and Quebec in the wind energy sector. Our qualitative and comparative approach helps us to illustrate the interaction of institutional variables studied, including the national context of emergence, the balance of power between pressure groups, the supranational and exogenous influences, level of political commitment, policy and regulatory instruments, social acceptance and energy policy mechanisms. The research confirms that the neo-corporatism is present in France as in Quebec. With the unfavorable energy context (low cost of electricity tariff, lack of electricity demand, and an already low zero carbon electric mix), it is an important factor explaining : 1) the 20 years delay accumulated by France and Quebec in the development of wind projects or industrial sector; 2) the 10% limited penetration scale given to wind energy. We also demonstrate that the political commitment to develop wind energy fluctuates with the government majority, the energy context or the influence of pressure groups. This manifests itself in a lack of continuity of policies and tariff instruments used. In both national case studies, the results also show that balanced policies and regulations ensure sustainable development of wind energy only if they allow a sufficient market size. The search results also illustrates that the conceptual division made between acceptance of wind sector, acceptance of ownership, local acceptance is very instructive. Social controversies, though multifactorial, are connected to both a critique of the development model too industrial and private, territorial dilemmas (closed environment), energy context (electric surplus in Quebec), or related to strategic planning system and centralized decision. An important issue for a more acceptable wind policy in the future will come to a greater plurality of ownership

  7. Preserving reptiles for research

    USGS Publications Warehouse

    Gotte, Steve W.; Jacobs, Jeremy F.; Zug, George R.

    2016-01-01

    What are voucher specimens and why do we collect them? Voucher specimens are animals and/or their parts that are deposited in a research museum to document the occurrence of a taxon at a specific location in space and time (Pleijel et al., 2008; Reynolds and McDiarmid, 2012). For field biologists, vouchers are the repeatable element of a field study as they allow other biologists, now and in the future, to confirm the identity of species that were studied. The scientific importance of a voucher specimen or series of specimens is that other people are afforded the opportunity to examine the entire animal and confirm or correct identifications. A photographic record is somewhat useful for recording the occurrence of a species, but such records can be insufficient for reliable confirmation of specific identity. Even if a photo shows diagnostic characters of currently recognized taxa, it may not show characters that separate taxa that may be described in the future. Substantial cryptic biodiversity is being found in even relatively well-known herpetofaunas (Crawford et al., 2010), and specimens allow researchers to retroactively evaluate the true diversity in a study as understanding of taxonomy evolves. They enable biologists to study the systematic relationships of populations by quantifying variation in different traits. Specimens are also a source of biological data such as behaviour, ecology, epidemiology, and reproduction through examination of their anatomy, reproductive and digestive tracts, and parasites (Suarez and Tsutsui, 2004). Preserving reptiles as vouchers is not difficult, although doing it properly requires care, effort, and time. Poorly preserved vouchers can invalidate the results and conclusions of your study because of the inability to confirm the identity of your study animals. Good science requires repeatability of observations, and the absence of vouchers or poorly preserved ones prevents such confirmation. Due to space restrictions, we are

  8. Baby-Crying Acceptance

    NASA Astrophysics Data System (ADS)

    Martins, Tiago; de Magalhães, Sérgio Tenreiro

    The baby's crying is his most important mean of communication. The crying monitoring performed by devices that have been developed doesn't ensure the complete safety of the child. It is necessary to join, to these technological resources, means of communicating the results to the responsible, which would involve the digital processing of information available from crying. The survey carried out, enabled to understand the level of adoption, in the continental territory of Portugal, of a technology that will be able to do such a digital processing. It was used the TAM as the theoretical referential. The statistical analysis showed that there is a good probability of acceptance of such a system.

  9. High acceptance recoil polarimeter

    SciTech Connect

    The HARP Collaboration

    1992-12-05

    In order to detect neutrons and protons in the 50 to 600 MeV energy range and measure their polarization, an efficient, low-noise, self-calibrating device is being designed. This detector, known as the High Acceptance Recoil Polarimeter (HARP), is based on the recoil principle of proton detection from np[r arrow]n[prime]p[prime] or pp[r arrow]p[prime]p[prime] scattering (detected particles are underlined) which intrinsically yields polarization information on the incoming particle. HARP will be commissioned to carry out experiments in 1994.

  10. Acceptance Test Plan for ANSYS Software

    SciTech Connect

    CREA, B.A.

    2000-10-25

    This plan governs the acceptance testing of the ANSYS software (Full Mechanical Release 5.5) for use on Project Word Management Contract (PHMC) computer systems (either UNIX or Microsoft Windows/NT). There are two phases to the acceptance testing covered by this test plan: program execution in accordance with the guidance provided in installation manuals; and ensuring results of the execution are consistent with the expected physical behavior of the system being modeled.

  11. Clinical guide to fertility preservation in hematopoietic cell transplant recipients.

    PubMed

    Joshi, S; Savani, B N; Chow, E J; Gilleece, M H; Halter, J; Jacobsohn, D A; Pidala, J; Quinn, G P; Cahn, J-Y; Jakubowski, A A; Kamani, N R; Lazarus, H M; Rizzo, J D; Schouten, H C; Socie, G; Stratton, P; Sorror, M L; Warwick, A B; Wingard, J R; Loren, A W; Majhail, N S

    2014-04-01

    With broadening indications, more options for hematopoietic cell transplantation (HCT) and improvement in survival, the number of long-term HCT survivors is expected to increase steadily. Infertility is a frequent problem that long-term HCT survivors and their partners face and it can negatively impact on the quality of life. The most optimal time to address fertility issues is before the onset of therapy for the underlying disease; however, fertility preservation should also be addressed before HCT in all children and patients of reproductive age, with referral to a reproductive specialist for patients interested in fertility preservation. In vitro fertilization (IVF) and embryo cryopreservation, oocyte cryopreservation and ovarian tissue banking are acceptable methods for fertility preservation in adult women/pubertal females. Sperm banking is the preferred method for adult men/pubertal males. Frequent barriers to fertility preservation in HCT recipients may include the perception of lack of time to preserve fertility given an urgency to move ahead with transplant, lack of patient-physician discussion because of several factors (for example, time constraints, lack of knowledge), inadequate access to reproductive specialists, and costs and lack of insurance coverage for fertility preservation. There is a need to raise awareness in the medical community about fertility preservation in HCT recipients. PMID:24419521

  12. Clinical guide to fertility preservation in hematopoietic cell transplant recipients

    PubMed Central

    Joshi, S; Savani, BN; Chow, EJ; Gilleece, MH; Halter, J; Jacobsohn, DA; Pidala, J; Quinn, GP; Cahn, J-Y; Jakubowski, AA; Kamani, NR; Lazarus, HM; Rizzo, JD; Schouten, HC; Socie, G; Stratton, P; Sorror, ML; Warwick, AB; Wingard, JR; Loren, AW; Majhail, NS

    2014-01-01

    With broadening indications, more options for hematopoietic cell transplantation (HCT) and improvement in survival, the number of long-term HCT survivors is expected to increase steadily. Infertility is a frequent problem that long-term HCT survivors and their partners face and it can negatively impact on the quality of life. The most optimal time to address fertility issues is before the onset of therapy for the underlying disease; however, fertility preservation should also be addressed before HCT in all children and patients of reproductive age, with referral to a reproductive specialist for patients interested in fertility preservation. In vitro fertilization (IVF) and embryo cryopreservation, oocyte cryopreservation and ovarian tissue banking are acceptable methods for fertility preservation in adult women/pubertal females. Sperm banking is the preferred method for adult men/pubertal males. Frequent barriers to fertility preservation in HCT recipients may include the perception of lack of time to preserve fertility given an urgency to move ahead with transplant, lack of patient–physician discussion because of several factors (for example, time constraints, lack of knowledge), inadequate access to reproductive specialists, and costs and lack of insurance coverage for fertility preservation. There is a need to raise awareness in the medical community about fertility preservation in HCT recipients. PMID:24419521

  13. Update on Dark Sky Preservation

    NASA Astrophysics Data System (ADS)

    Crawford, D. L.

    1998-12-01

    The efforts to protect dark skies for astronomy and for the public are accelerating. An increasing number of cities and states are considering and enacting outdoor lighting control ordinances. Examples of such lighting codes and a model code are available from the International Dark-Sky Association's Web page, at www.darksky.org. There will be a major meeting on Preserving the Astronomical Environment, IAU Symposium #196, co-sponsored by the United Nations, IDA, and others, to be held the week of 12 July 1999 in Vienna, Austria. Further information on this meeting (and others) can also be found on the IDA Web site, which also contains many other resources (and links to other web sites) for those interested in the issues.

  14. Preservation of Human Cornea

    PubMed Central

    Armitage, W. John

    2011-01-01

    Summary The successful outcome of the majority of corneal transplants depends on the presence of a viable corneal endothelium. This monolayer of cells lines the inner surface of the cornea and its primary function is to maintain corneal transparency by controlling the hydration of the collagenous stromal layer. Since human corneal endothelial cells do not readily proliferate, preservation of the endothelium is a primary aim of methods of corneal storage. Although some cryopreserved corneas have been transplanted successfully, the complexity of the cryopreservation technique and its potential for causing endothelial damage have limited its application. Hypothermia (2–8 °C) is the most commonly applied method of storage, which allows storage for 7–14 days. Organ culture (28–37 °C), which extends storage time to 4 weeks, is used widely in European eye banks. Graft outcomes for corneas stored by these two techniques appear similar. PMID:21566714

  15. Orbital preservation in maxillectomy.

    PubMed

    Stern, S J; Goepfert, H; Clayman, G; Byers, R; Wolf, P

    1993-07-01

    Twenty-eight previously untreated patients with squamous carcinoma of the maxillary sinus underwent maxillectomy with preservation of the orbital contents at the M. D. Anderson Cancer Center between 1971 and 1986. Eighteen patients had part or all of the orbital floor resected; nine patients were treated with radiotherapy, and nine had surgery only. Only 3 of 18 patients in this group (17%) retained significant function in the ipsilateral eye. Furthermore, local recurrence in this group was common (44%), regardless of whether postoperative radiotherapy was used. Ten patients retained the bony orbital floor; if the radiation fields did not include the eye, problems were minimal. Strong consideration should be given to orbital exenteration at the time of surgery, when the orbital floor is resected--especially if postoperative radiation fields will include the eye. PMID:8336956

  16. Format-Preserving Encryption

    NASA Astrophysics Data System (ADS)

    Bellare, Mihir; Ristenpart, Thomas; Rogaway, Phillip; Stegers, Till

    Format-preserving encryption (FPE) encrypts a plaintext of some specified format into a ciphertext of identical format—for example, encrypting a valid credit-card number into a valid credit-card number. The problem has been known for some time, but it has lacked a fully general and rigorous treatment. We provide one, starting off by formally defining FPE and security goals for it. We investigate the natural approach for achieving FPE on complex domains, the “rank-then-encipher” approach, and explore what it can and cannot do. We describe two flavors of unbalanced Feistel networks that can be used for achieving FPE, and we prove new security results for each. We revisit the cycle-walking approach for enciphering on a non-sparse subset of an encipherable domain, showing that the timing information that may be divulged by cycle walking is not a damaging thing to leak.

  17. Privacy-Preserving Restricted Boltzmann Machine

    PubMed Central

    Li, Yu

    2014-01-01

    With the arrival of the big data era, it is predicted that distributed data mining will lead to an information technology revolution. To motivate different institutes to collaborate with each other, the crucial issue is to eliminate their concerns regarding data privacy. In this paper, we propose a privacy-preserving method for training a restricted boltzmann machine (RBM). The RBM can be got without revealing their private data to each other when using our privacy-preserving method. We provide a correctness and efficiency analysis of our algorithms. The comparative experiment shows that the accuracy is very close to the original RBM model. PMID:25101139

  18. Privacy-preserving restricted boltzmann machine.

    PubMed

    Li, Yu; Zhang, Yuan; Ji, Yue

    2014-01-01

    With the arrival of the big data era, it is predicted that distributed data mining will lead to an information technology revolution. To motivate different institutes to collaborate with each other, the crucial issue is to eliminate their concerns regarding data privacy. In this paper, we propose a privacy-preserving method for training a restricted boltzmann machine (RBM). The RBM can be got without revealing their private data to each other when using our privacy-preserving method. We provide a correctness and efficiency analysis of our algorithms. The comparative experiment shows that the accuracy is very close to the original RBM model. PMID:25101139

  19. A Widening Circle: Preservation Literature Review, 1992.

    ERIC Educational Resources Information Center

    Drewes, Jeanne M.

    1993-01-01

    Examines preservation literature from 1992 that focused on the integration of preservation strategies within the organization. Highlights include foreign preservation programs; collection development and preservation; government programs; deacidification; paper requirements; disaster recovery techniques; mutilation; microform issues; nonbook…

  20. Privacy-preserving backpropagation neural network learning.

    PubMed

    Chen, Tingting; Zhong, Sheng

    2009-10-01

    With the development of distributed computing environment , many learning problems now have to deal with distributed input data. To enhance cooperations in learning, it is important to address the privacy concern of each data holder by extending the privacy preservation notion to original learning algorithms. In this paper, we focus on preserving the privacy in an important learning model, multilayer neural networks. We present a privacy-preserving two-party distributed algorithm of backpropagation which allows a neural network to be trained without requiring either party to reveal her data to the other. We provide complete correctness and security analysis of our algorithms. The effectiveness of our algorithms is verified by experiments on various real world data sets. PMID:19709975

  1. The Acceptance and Use of Computer Based Assessment

    ERIC Educational Resources Information Center

    Terzis, Vasileios; Economides, Anastasios A.

    2011-01-01

    The effective development of a computer based assessment (CBA) depends on students' acceptance. The purpose of this study is to build a model that demonstrates the constructs that affect students' behavioral intention to use a CBA. The proposed model, Computer Based Assessment Acceptance Model (CBAAM) is based on previous models of technology…

  2. Changes in Parental Depression Symptoms during Family Preservation Services

    ERIC Educational Resources Information Center

    Chaffin, Mark; Bard, David

    2011-01-01

    Objectives: Parental depression symptoms often change over the course of child welfare family preservation and parenting services. This raises the question of whether certain processes in family preservation services might be associated with depression symptom change. This study tests three correlational models of change among family preservation…

  3. Historic Preservation in Art Education

    ERIC Educational Resources Information Center

    Guilfoil, Joanne K.

    2004-01-01

    The Blue Grass Trust in Lexington, Kentucky sponsors the annual visual art contest for historic preservation, one of the many events they sponsor as part of the celebrations planned for Historic Preservation Month each May. When the announcement concerning the Blue Grass Trust visual art competition is released, area high school art teachers…

  4. Preservation of Liquid Biological Samples

    NASA Technical Reports Server (NTRS)

    Putcha, Lakshmi (Inventor); Nimmagudda, Ramalingeshwara R. (Inventor)

    2000-01-01

    The present invention provides a method of preserving a liquid biological sample, comprising the step of: contacting said liquid biological sample with a preservative comprising, sodium benzoate in an amount of at least about 0.15% of the sample (weight/volume) and citric acid in an amount of at least about 0.025% of the sample (weight/volume).

  5. Entanglement preservation by continuous distillation

    SciTech Connect

    Mundarain, D.; Orszag, M.

    2009-05-15

    We study the two-qubit entanglement preservation for a system in the presence of independent thermal baths. We use a combination of filtering operations and distillation protocols as a series of frequent measurements on the system. It is shown that a small fraction of the total amount of available copies of the system preserves or even improves its initial entanglement during the evolution.

  6. Sharing and Preserving Family Stories.

    ERIC Educational Resources Information Center

    Dobrez, Cynthia K.

    1987-01-01

    One public library's storytelling program for fourth through eighth graders and their grandparents has preserved grandparents' stories and fostered family communication. Storytelling was done one-on-one, with each child then writing and illustrating the story. Benefits included preservation of oral history and encouragement of storytelling,…

  7. Preservation Methods for Digital Library

    ERIC Educational Resources Information Center

    Rajendran, L.; Venkatesan, M.; Kanthimathi, S.

    2005-01-01

    Going digital is the way to minimize handling of damaged materials, but the imaging process is demanding and must be done with oversight by preservation staff and with a high enough level of quality to ensure the reusability of the archival electronic file for as long as possible. This paper focuses on the scope and needs of digital preservation,…

  8. Collections Security: The Preservation Perspective.

    ERIC Educational Resources Information Center

    Patkus, Beth L.

    1998-01-01

    Provides a brief review of the basic elements of library security and preservation programs as a background for an exploration of security/preservation issues, problems, and policies. Discusses environmental control, disaster preparedness, fire protection, storage and handling, and controlling access to collections. (AEF)

  9. Factors influencing organic carbon preservation in marine sediments

    NASA Technical Reports Server (NTRS)

    Canfield, D. E.

    1994-01-01

    The organic matter that escapes decomposition is buried and preserved in marine sediments, with much debate as to whether the amount depends on bottom-water O2 concentration. One group argues that decomposition is more efficient with O2, and hence, organic carbon will be preferentially oxidized in its presence, and preserved in its absence. Another group argues that the kinetics of organic matter decomposition are similar in the presence and absence of O2, and there should be no influence of O2 on preservation. A compilation of carbon preservation shows that both groups are right, depending on the circumstances of deposition. At high rates of deposition, such as near continental margins, little difference in preservation is found with varying bottom-water O2. It is important that most carbon in these sediments decomposes by anaerobic pathways regardless of bottom-water O2. Hence, little influence of bottom-water O2 on preservation would, in fact, be expected. As sedimentation rate drops, sediments deposited under oxygenated bottom water become progressively more aerobic, while euxinic sediments remain anaerobic. Under these circumstances, the relative efficiencies of aerobic and anaerobic decomposition could affect preservation. Indeed, enhanced preservation is observed in low-O2 and euxinic environments. To explore in detail the factors contributing to this enhanced carbon preservation, aspects of the biochemistries of the aerobic and anaerobic process are reviewed. Other potential influences on preservation are also explored. Finally, a new model for organic carbon decomposition, the "pseudo-G" model, is developed. This model couples the degradation of refractory organic matter to the overall metabolic activity of the sediment, and has consequences for carbon preservation due to the mixing together of labile and refractory organic matter by bioturbation.

  10. The stratified microbial community at Laguna Figueroa, Baja California, Mexico: A possible model for prephanerozoic laminated microbial communities preserved in cherts

    NASA Astrophysics Data System (ADS)

    Stolz, John F.; Margulis, Lynn

    1984-12-01

    The microbial mat community of the evaporite flat at North Pond, Laguna Figueroa (Baja California, Mexico) was actively involved in the production of laminated sediments prior to 1978. Heavy rains in 1979 and 1980 flooded the mat with 1 and 3 meters of meteoric water respectively. The flooding deposited up to 10 cm of silicoclastic sediment over theMicrocoleus-dominated mat and resulted in the cessation of laminated sediment deposition. In 1982, the surface had been recolonized by species of cyanobacteria (Spirulina, Oscillatoria) and purple photosynthetic bacteria (Chromatium, Thiocapsa). The silicoclastic sediments and residual evaporites, which overlaid the laminated sediment, had been reworked into an anaerobic, sulfide-rich mud and contained well preserved sheaths of filamentous and coccoid bacteria.

  11. Preserving Dignity in Later Life.

    PubMed

    São José, José Manuel

    2016-09-01

    This article examines how elders who receive social care in the community experience loss of dignity and how they preserve their dignity. Qualitative research revealed that loss of dignity is a major concern for these elders and that they preserve their dignity differently, ranging from actively engaging with life to detaching themselves from life. We conclude that, in later life, preserving dignity while receiving social care differs from preserving dignity in the context of health care, especially health care provided in institutional settings. Furthermore, preserving dignity in later life, while receiving social care, is a complex process, depending not only on performing activities and individual action and responsibility, but also on other actions, some of them involving a certain inactivity/passivity, and interactions with others, especially caregivers. This article offers some insights to developing better policies and care practices for promoting dignity in the context of community-based social care. PMID:27456751

  12. Contact dermatitis caused by preservatives.

    PubMed

    Yim, Elizabeth; Baquerizo Nole, Katherine L; Tosti, Antonella

    2014-01-01

    Preservatives are biocidal chemicals added to food, cosmetics, and industrial products to prevent the growth of microorganisms. They are usually nontoxic and inexpensive and have a long shelf life. Unfortunately, they commonly cause contact dermatitis. This article reviews the most important classes of preservatives physicians are most likely to encounter in their daily practice, specifically isothiazolinones, formaldehyde and formaldehyde-releasers, iodopropynyl butylcarbamate, methyldibromoglutaronitrile, and parabens. For each preservative mentioned, the prevalence of sensitization, clinical presentation of contact dermatitis, patch testing concentrations, cross reactions, and related legislation will be discussed. Mandatory labeling of preservatives is required in some countries, but not required in others. Until policies are made, physicians and patients must be proactive in identifying potential sensitizers and removing their use. We hope that this article will serve as a guide for policy makers in creating legislation and future regulations on the use and concentration of certain preservatives in cosmetics and industrial products. PMID:25207684

  13. Anti-arrhythmic effects of atrial ganglionated plexi stimulation is accompanied by preservation of connexin43 protein in ischemia-reperfusion canine model

    PubMed Central

    Wang, Songyun; Li, Hewei; Yu, Lilei; Chen, Mingxian; Wang, Zhuo; Huang, Bing; Zhou, Liping; Zhou, Xiaoya; Jiang, Hong

    2015-01-01

    Background: Vagal nerve stimulation (VNS) has been shown to provide a protective effect against ischemia/reperfusion (I/R)-related arrhythmias by preventing the loss of Connexin43 (Cx43). Our previous studies showed that atrial epicardial ganglionated plexus stimulation (GPS) might exert a VNS-like effect on ventricular electrophysiology. Objectives: To investigate whether GPS could preserve Cx43 and reduce I/R induced ventricular arrhythmia. Methods: Sixteen dogs were randomly divided into GPS group (N = 8, receiving GPS) and Sham group (N = 8, receiving sham GPS). Ventricular effective refractory period (ERP) and heart rate variability (HRV) were measured at baseline and 1 h after GPS. Myocardial I/R was then performed. Ventricular arrhythmia occurred during the first hour after reperfusion was measured and myocardial tissue from the peri-infarct zone was excised for immunohistological analysis. In another 4 dogs (Control group, receiving sham GPS and sham I/R), myocardial tissue from the corresponding area was also excised. Results: Compared with the Sham group, GPS caused a significant increase in ventricular ERP and HRV, and a significant decrease in I/R-induced ventricular arrhythmias. Western blotting revealed a marked reduction in the amount of phosphorylated Cx43 and total Cx43 in the Sham group, whereas no significant change was observed in the GPS group compared with the Control group. Immunohistochemistry results confirmed that the myocardial I/R-induced loss of phosphorylated Cx43 from the intercellular junctions was prevented by GPS. Conclusion: GPS protects against I/R induced ventricular arrhythmias, accompanied by preserving Cx43. PMID:26885184

  14. Preserving Observatory Publications: Microfilming, Scanning...What's Next?

    NASA Astrophysics Data System (ADS)

    Coletti, Donna J.

    Since 1996, the John G. Wolbach Library & Information Resource Center at the Harvard-Smithsonian Center for Astrophysics has participated in a preservation project, funded by the U. S. National Endowment for the Humanities and carried out at Harvard University's Weissman Preservation Center, to preserve the history of science. More than 2,000 volumes of Wolbach Library's 3,000 volume collection of historical observatory publications from around the world have already been preserved on microfilm. A follow-up project to convert the collection to digital format was begun in the year 2000. Meanwhile, Harvard University unveiled its Digital Repository Service (DRS) offering state-of-the-art storage and retrieval of digital collections. DRS goes further than our previous projects by offering full-text searching, page turning capability, color plates, strict metadata requirements, persistent links using universal resource names, reformatting as necessary, and perpetual storage. Harvard also offers the service and guidance of preservation experts from its state-of-the-art Imaging Service and Preservation Department. In anticipation of the LISA IV meeting in Prague, Wolbach Library issued a challenge to Harvard, ``Show us what you can do with a brittle volume from the Observatory Publication collection.'' Harvard accepted. The result is included in this paper and links are provided to allow the reader closer scrutiny of the final product.

  15. Computer acceptance of older adults.

    PubMed

    Nägle, Sibylle; Schmidt, Ludger

    2012-01-01

    Even though computers play a massive role in everyday life of modern societies, older adults, and especially older women, are less likely to use a computer, and they perform fewer activities on it than younger adults. To get a better understanding of the factors affecting older adults' intention towards and usage of computers, the Unified Theory of Acceptance and Usage of Technology (UTAUT) was applied as part of a more extensive study with 52 users and non-users of computers, ranging in age from 50 to 90 years. The model covers various aspects of computer usage in old age via four key constructs, namely performance expectancy, effort expectancy, social influences, and facilitating conditions, as well as the variables gender, age, experience, and voluntariness it. Interestingly, next to performance expectancy, facilitating conditions showed the strongest correlation with use as well as with intention. Effort expectancy showed no significant correlation with the intention of older adults to use a computer. PMID:22317258

  16. Sonic boom acceptability studies

    NASA Astrophysics Data System (ADS)

    Shepherd, Kevin P.; Sullivan, Brenda M.; Leatherwood, Jack D.; McCurdy, David A.

    1992-04-01

    The determination of the magnitude of sonic boom exposure which would be acceptable to the general population requires, as a starting point, a method to assess and compare individual sonic booms. There is no consensus within the scientific and regulatory communities regarding an appropriate sonic boom assessment metric. Loudness, being a fundamental and well-understood attribute of human hearing was chosen as a means of comparing sonic booms of differing shapes and amplitudes. The figure illustrates the basic steps which yield a calculated value of loudness. Based upon the aircraft configuration and its operating conditions, the sonic boom pressure signature which reaches the ground is calculated. This pressure-time history is transformed to the frequency domain and converted into a one-third octave band spectrum. The essence of the loudness method is to account for the frequency response and integration characteristics of the auditory system. The result of the calculation procedure is a numerical description (perceived level, dB) which represents the loudness of the sonic boom waveform.

  17. Sonic boom acceptability studies

    NASA Technical Reports Server (NTRS)

    Shepherd, Kevin P.; Sullivan, Brenda M.; Leatherwood, Jack D.; Mccurdy, David A.

    1992-01-01

    The determination of the magnitude of sonic boom exposure which would be acceptable to the general population requires, as a starting point, a method to assess and compare individual sonic booms. There is no consensus within the scientific and regulatory communities regarding an appropriate sonic boom assessment metric. Loudness, being a fundamental and well-understood attribute of human hearing was chosen as a means of comparing sonic booms of differing shapes and amplitudes. The figure illustrates the basic steps which yield a calculated value of loudness. Based upon the aircraft configuration and its operating conditions, the sonic boom pressure signature which reaches the ground is calculated. This pressure-time history is transformed to the frequency domain and converted into a one-third octave band spectrum. The essence of the loudness method is to account for the frequency response and integration characteristics of the auditory system. The result of the calculation procedure is a numerical description (perceived level, dB) which represents the loudness of the sonic boom waveform.

  18. Open collagen membrane technique in socket preservation.

    PubMed

    Cheng, Wen-Yen

    2016-01-01

    Both hard and soft tissue undergo change after tooth extraction. In particular, the bone tissue surrounding teeth with fenestration or dehiscence defects undergoes dramatic change following tooth extraction, which can compromise further rehabilitation of the area. Adequate alveolar bone volume and keratinized mucosa are critical to the success of implant therapy. Therefore, the anatomic dimension of the alveolar ridge must be adequate to achieve an esthetically acceptable outcome of implant therapy. Previous studies have proposed many clinical techniques for preserving the extraction socket. This article presents a procedure in which an open collagen membrane technique was adopted to maintain an adequate volume of hard tissue and a sufficient width of the keratinized mucosa for further esthetic and functional implantation. Through this simple technique, an adequate volume and architecture around the implant can be achieved, with a long-term prognosis for implant therapy expected. PMID:27433553

  19. Coatings to reduce wood preservative leaching.

    PubMed

    Nejad, Mojgan; Cooper, Paul

    2010-08-15

    The efficiency of semitransparent penetrating stains to reduce leaching of wood preservative components was evaluated. Five commercial wood deck finishes were applied to untreated and chromated copper arsenate (CCA), alkaline copper quat (ACQ), and copper azole (CA) treated wood, and leachates were collected and analyzed during 3 years of natural weathering exposure in Toronto, Canada. All stains evaluated effectively reduced the cumulative leaching of all inorganic preservative components by about 60% on average. Although most coatings showed significant film degradation starting around 12 months, the reduced leaching persisted even after 3 years. This suggests that temporary protection of wood with a coating during the early stages of use resulted in long-term reduction in preservative leaching potential. A two-week screening leaching test was able to predict the long-term leaching performance of different coatings reasonably well. Cured coating glass transition temperature (Tg) and liquid coating viscosity were the most important variables affecting a leaching prediction model. To effectively reduce leaching of preservative components from treated wood, coatings should have Tg low enough to withstand stresses caused by freezing in winter and have adequate viscosity to form a barrier film layer on the wood surface. PMID:20704213

  20. Knowledge Preservation and Web-tools

    NASA Technical Reports Server (NTRS)

    Moreman, Douglas; Dyer, John; Ahmad, Rashed

    1998-01-01

    We propose a library of "netbooks" as part of a national effort, preserving the wisdom of the early Space Program. NASA is losing its rocket scientists who designed the great systems of the past. Few new systems of similar ambition are being built; much of the expertise that took us to the Moon is evaporating. With retiring NASA designers, we work to preserve something of the expertise of these individuals, developed at great national cost. We show others the tools that make preservation easy and cheap. Retiring engineers and scientists can be coached into speaking (without charge) into recording devices about ideas not widely appreciated but of potential future value. Transcripts of the recordings and the audio itself are combined (cheaply) in netbooks accessible via a standard web-browser (free). Selected netbooks are indexed into a rapidly searchable system, an electronic Library. We recruit support in establishing a standards committee for that Library. The system is to be a model for access by the blind as well as for preservation of important, technical knowledge.

  1. Solidago canadensis L. Essential Oil Vapor Effectively Inhibits Botrytis cinerea Growth and Preserves Postharvest Quality of Strawberry as a Food Model System

    PubMed Central

    Liu, Shumin; Shao, Xingfeng; Wei, Yanzhen; Li, Yonghua; Xu, Feng; Wang, Hongfei

    2016-01-01

    This study investigated the anti-fungal properties of Solidago canadensis L. essential oil (SCLEO) against Botrytis cinerea in vitro, and its ability to control gray mold and maintain quality in strawberry fruits. SCLEO exhibited dose-dependent antifungal activity against B. cinerea and profoundly altered mycelial morphology, cellular ultrastructure, and membrane permeability as evaluated by scanning electron microscopy, transmission electron microscopy, and fluorescence microscopy. SCLEO vapor at 0.1 mL/L maintained higher sensory acceptance and reduced decay of fresh strawberry fruit, and also reduced gray mold in artificially inoculated fruit. SCLEO treatment did not, however, stimulate phenylalanin ammonia-lyase, polyphenol oxidase, or chitinase, enzymes related to disease resistance. This suggests that SCLEO reduces gray mold by direct inhibition of pathogen growth. SCLEO vapor may provide a new and effective strategy for controlling postharvest disease and maintaining quality in strawberries. PMID:27531994

  2. Solidago canadensis L. Essential Oil Vapor Effectively Inhibits Botrytis cinerea Growth and Preserves Postharvest Quality of Strawberry as a Food Model System.

    PubMed

    Liu, Shumin; Shao, Xingfeng; Wei, Yanzhen; Li, Yonghua; Xu, Feng; Wang, Hongfei

    2016-01-01

    This study investigated the anti-fungal properties of Solidago canadensis L. essential oil (SCLEO) against Botrytis cinerea in vitro, and its ability to control gray mold and maintain quality in strawberry fruits. SCLEO exhibited dose-dependent antifungal activity against B. cinerea and profoundly altered mycelial morphology, cellular ultrastructure, and membrane permeability as evaluated by scanning electron microscopy, transmission electron microscopy, and fluorescence microscopy. SCLEO vapor at 0.1 mL/L maintained higher sensory acceptance and reduced decay of fresh strawberry fruit, and also reduced gray mold in artificially inoculated fruit. SCLEO treatment did not, however, stimulate phenylalanin ammonia-lyase, polyphenol oxidase, or chitinase, enzymes related to disease resistance. This suggests that SCLEO reduces gray mold by direct inhibition of pathogen growth. SCLEO vapor may provide a new and effective strategy for controlling postharvest disease and maintaining quality in strawberries. PMID:27531994

  3. Privacy preserving RBF kernel support vector machine.

    PubMed

    Li, Haoran; Xiong, Li; Ohno-Machado, Lucila; Jiang, Xiaoqian

    2014-01-01

    Data sharing is challenging but important for healthcare research. Methods for privacy-preserving data dissemination based on the rigorous differential privacy standard have been developed but they did not consider the characteristics of biomedical data and make full use of the available information. This often results in too much noise in the final outputs. We hypothesized that this situation can be alleviated by leveraging a small portion of open-consented data to improve utility without sacrificing privacy. We developed a hybrid privacy-preserving differentially private support vector machine (SVM) model that uses public data and private data together. Our model leverages the RBF kernel and can handle nonlinearly separable cases. Experiments showed that this approach outperforms two baselines: (1) SVMs that only use public data, and (2) differentially private SVMs that are built from private data. Our method demonstrated very close performance metrics compared to nonprivate SVMs trained on the private data. PMID:25013805

  4. Human embryonic stem cell-derived mesenchymal cells preserve kidney function and extend lifespan in NZB/W F1 mouse model of lupus nephritis.

    PubMed

    Thiel, Austin; Yavanian, Gregory; Nastke, Maria-Dorothea; Morales, Peter; Kouris, Nicholas A; Kimbrel, Erin A; Lanza, Robert

    2015-01-01

    Adult tissue-derived mesenchymal stromal cells (MSCs) are showing promise in clinical trials for systemic lupus erythematosus (SLE). However, the inability to manufacture large quantities of functional cells from a single donor as well as donor-dependent variability in quality limits their clinical utility. Human embryonic stem cell (hESC)-derived MSCs are an alternative to adult MSCs that can circumvent issues regarding scalability and consistent quality due to their derivation from a renewable starting material. Here, we show that hESC-MSCs prevent the progression of fatal lupus nephritis (LN) in NZB/W F1 (BWF1) mice. Treatment led to statistically significant reductions in proteinuria and serum creatinine and preserved renal architecture. Specifically, hESC-MSC treatment prevented disease-associated interstitial inflammation, protein cast deposition, and infiltration of CD3(+) lymphocytes in the kidneys. This therapy also led to significant reductions in serum levels of tumor necrosis factor alpha (TNFα) and interleukin 6 (IL-6), two inflammatory cytokines associated with SLE. Mechanistically, in vitro data support these findings, as co-culture of hESC-MSCs with lipopolysaccharide (LPS)-stimulated BWF1 lymphocytes decreased lymphocyte secretion of TNFα and IL-6, and enhanced the percentage of putative regulatory T cells. This study represents an important step in the development of a commercially scalable and efficacious cell therapy for SLE/LN. PMID:26628350

  5. CO2 Pneumoperitoneum Preserves β-Arrestin 2 Content and Reduces High Mobility Group Box-1 (HMGB-1) Expression in an Animal Model of Peritonitis

    PubMed Central

    Montalto, Angela Simona; Minutoli, Letteria; Impellizzeri, Pietro; Costa, Gaetano; Squadrito, Francesco

    2015-01-01

    Laparoscopy (LS) has been shown to decrease the inflammatory sequelae of endotoxemia. β-arrestin 2 plays an important function in signal transduction pathway of TLR4. High mobility group box-1 (HMGB-1) is involved in the delayed systemic inflammatory response. We investigated the effects of CO2 insufflation on liver, lung, and kidney expression of both β-arrestin 2 and HMGB-1 during sepsis. Cecal ligation and puncture (CLP) was performed in male rats and 6 h later the animals were randomly assigned to receive a CO2 pneumoperitoneum or laparotomy. Animals were euthanized; liver, lung, and kidney were removed for the evaluation of β-arrestin 2 and HMGB-1 expression. Immunohistochemical detection of myeloperoxidase (MPO) was investigated in lung and liver and bacterial load was determined in the peritoneal fluid. CO2 pneumoperitoneum reduced peritoneal bacterial load, increased the expression of β-arrestin 2, and blunted the expression of the potent proinflammatory HMGB-1 in liver, lung, and kidney compared with laparotomy. Liver and lung MPO was markedly reduced in rats subjected to LS compared with laparotomy. We believe that CO2 exerts an early protective effect by reducing bacterial load and likely toll-like receptor activation which in turn leads to a preserved β-arrestin 2 expression and a reduced HMGB-1 expression. PMID:25810808

  6. Isolation of Pancreatic Cancer Cells from a Patient-Derived Xenograft Model Allows for Practical Expansion and Preserved Heterogeneity in Culture.

    PubMed

    Pham, Kien; Delitto, Daniel; Knowlton, Andrea E; Hartlage, Emily R; Madhavan, Ricky; Gonzalo, David H; Thomas, Ryan M; Behrns, Kevin E; George, Thomas J; Hughes, Steven J; Wallet, Shannon M; Liu, Chen; Trevino, Jose G

    2016-06-01

    Commercially available, highly passaged pancreatic cancer (PC) cell lines are of limited translational value. Attempts to overcome this limitation have primarily consisted of cancer cell isolation and culture directly from human PC specimens. However, these techniques are associated with exceedingly low success rates. Here, we demonstrate a highly reproducible culture of primary PC cell lines (PPCLs) from patient-derived xenografts, which preserve, in part, the intratumoral heterogeneity known to exist in PC. PPCL expansion from patient-derived xenografts was successful in 100% of attempts (5 of 5). Phenotypic analysis was evaluated with flow cytometry, immunofluorescence microscopy, and short tandem repeat profiling. Importantly, tumorigenicity of PPCLs expanded from patient-derived xenografts was assessed by subcutaneous injection into nonobese diabeteic.Cg-Prkdc(scid)Il2rg(tm1Wjl)/SzJ mice. Morphologically, subcutaneous injection of all PPCLs into mice yielded tumors with similar characteristics to the parent xenograft. PPCLs uniformly expressed class I human leukocyte antigen, epithelial cell adhesion molecule, and cytokeratin-19. Heterogeneity within each PPCL persisted in culture for the frequency of cells expressing the cancer stem cell markers CD44, CD133, and c-Met and the immunologic markers human leukocyte antigen class II and programmed death ligand 1. This work therefore presents a reliable method for the rapid expansion of primary human PC cells and, thereby, provides a platform for translational investigation and, importantly, potential personalized therapeutic approaches. PMID:27102771

  7. Cultural Preservation Program for Alaska

    ERIC Educational Resources Information Center

    Barbaran, Francisco Ramon

    2011-01-01

    In this technical report, an innovative cultural preservation program for implementation in Athabascan villages is presented. The parameters for success in implementing such a project is discussed based on a workshop with Athabascan elders.

  8. Preservation of Liquid Biological Samples

    NASA Technical Reports Server (NTRS)

    Putcha, Lakshmi (Inventor); Nimmagudda, Ramalingeshwara (Inventor)

    2004-01-01

    The present invention related to the preservation of a liquid biological sample. The biological sample is exposed to a preservative containing at least about 0.15 g of sodium benzoate and at least about 0.025 g of citric acid per 100 ml of sample. The biological sample may be collected in a vessel or an absorbent mass. The biological sample may also be exposed to a substrate and/or a vehicle.

  9. NONCONVEX REGULARIZATION FOR SHAPE PRESERVATION

    SciTech Connect

    CHARTRAND, RICK

    2007-01-16

    The authors show that using a nonconvex penalty term to regularize image reconstruction can substantially improve the preservation of object shapes. The commonly-used total-variation regularization, {integral}|{del}u|, penalizes the length of the object edges. They show that {integral}|{del}u|{sup p}, 0 < p < 1, only penalizes edges of dimension at least 2-p, and thus finite-length edges not at all. We give numerical examples showing the resulting improvement in shape preservation.

  10. Fast Reactor Technology Preservation

    SciTech Connect

    Wootan, David W.; Omberg, Ronald P.

    2008-01-11

    There is renewed worldwide interest in developing and implementing a new generation of advanced fast reactors. International cooperative efforts are underway such as the Global Nuclear Energy Partnership (GNEP). Advanced computer modeling and simulation efforts are a key part of these programs. A recognized and validated set of Benchmark Cases are an essential component of such modeling efforts. Testing documentation developed during the operation of the Fast Flux Test Facility (FFTF) provide the information necessary to develop a very useful set of Benchmark Cases.

  11. Folliculogenesis Is Not Fully Inhibited during GnRH Analogues Treatment in Mice Challenging Their Efficiency to Preserve the Ovarian Reserve during Chemotherapy in This Model

    PubMed Central

    Horicks, Florence; Van Den Steen, Géraldine; Houben, Sarah; Englert, Yvon; Demeestere, Isabelle

    2015-01-01

    As many chemotherapy regimens induce follicular depletion, fertility preservation became a major concern in young cancer patients. By maintaining follicles at the resting stage, gonadotropin-releasing hormone analogues (GnRHa) were proposed as an ovarian-protective option during chemotherapy. However, their efficacy and mechanisms of action remain to be elucidated. Mice were dosed with cyclophosphamide (Cy, 100–500mg/kg i.p) to quantify follicular depletion and evaluate apoptosis at different times. We observed a dose-dependent depletion of the follicular reserve within 24 hours after Cy injection with a mean follicular loss of 45% at the dose of 200mg/kg. Apoptosis occurs in the granulosa cells of growing follicles within 12 hours after Cy treatment, while no apoptosis was detected in resting follicles suggesting that chemotherapy acutely affects both resting and growing follicles through different mechanisms. We further tested the ability of both GnRH agonist and antagonist to inhibit oestrus cycles, follicular growth and FSH secretion in mice and to protect ovarian reserve against chemotherapy. Although GnRHa were efficient to disrupt oestrus cycles, they failed to inhibit follicular development, irrespective of the doses and injection sites (sc or im). Around 20% of healthy growing follicles were still observed during GnRHa treatment and serum FSH levels were not reduced either by antagonist or agonist. GnRHa had no effect on Cy-induced follicular damages. Thus, we showed that GnRHa were not as efficient at inhibiting the pituitary-gonadal axis in mice as in human. Furthermore, the acute depletion of primordial follicles observed after chemotherapy does not support the hypothesis that the ovary may be protected by gonadotropin suppression. PMID:26325271

  12. Folliculogenesis Is Not Fully Inhibited during GnRH Analogues Treatment in Mice Challenging Their Efficiency to Preserve the Ovarian Reserve during Chemotherapy in This Model.

    PubMed

    Horicks, Florence; Van Den Steen, Géraldine; Houben, Sarah; Englert, Yvon; Demeestere, Isabelle

    2015-01-01

    As many chemotherapy regimens induce follicular depletion, fertility preservation became a major concern in young cancer patients. By maintaining follicles at the resting stage, gonadotropin-releasing hormone analogues (GnRHa) were proposed as an ovarian-protective option during chemotherapy. However, their efficacy and mechanisms of action remain to be elucidated. Mice were dosed with cyclophosphamide (Cy, 100-500 mg/kg i.p) to quantify follicular depletion and evaluate apoptosis at different times. We observed a dose-dependent depletion of the follicular reserve within 24 hours after Cy injection with a mean follicular loss of 45% at the dose of 200mg/kg. Apoptosis occurs in the granulosa cells of growing follicles within 12 hours after Cy treatment, while no apoptosis was detected in resting follicles suggesting that chemotherapy acutely affects both resting and growing follicles through different mechanisms. We further tested the ability of both GnRH agonist and antagonist to inhibit oestrus cycles, follicular growth and FSH secretion in mice and to protect ovarian reserve against chemotherapy. Although GnRHa were efficient to disrupt oestrus cycles, they failed to inhibit follicular development, irrespective of the doses and injection sites (sc or im). Around 20% of healthy growing follicles were still observed during GnRHa treatment and serum FSH levels were not reduced either by antagonist or agonist. GnRHa had no effect on Cy-induced follicular damages. Thus, we showed that GnRHa were not as efficient at inhibiting the pituitary-gonadal axis in mice as in human. Furthermore, the acute depletion of primordial follicles observed after chemotherapy does not support the hypothesis that the ovary may be protected by gonadotropin suppression. PMID:26325271

  13. Evaluation of preservative engine oil containing vapor-phase corrosion inhibitor and a simplified engine-preservation technique. Interim report, Jul 85-Sep 90

    SciTech Connect

    Frame, E.A.

    1990-12-01

    The objectives of this project were: (1) to determine the feasibility of adding a vapor-phase corrosion inhibitor (VCI) component to improve the preservation performance of MIL-L-21260 and (2) to evaluate a less complicated engine preservation procedure. A simultaneous two-phase approach was conducted. Phase 1 involved the formulation and evaluation of experimental VCI oils, while Phase 2 was the evaluation of a simplified engine preservation procedure. VCI oil formulation was conducted by Ronco Laboratory under subcontract. Compatibility of the experimental VCI oils with metal coupons, elastomers, and fuel filters was determined. Effectiveness of the experimental VCI oil was evaluated in a 3-year outdoor engine storage test. The engines were preserved using an experimental, simplified preservation procedure. The simplified engine preservation procedure proved to be acceptable as engines stored for 3 years in a very severe environment were judged to have been adequately preserved. Engine oil meeting specification MIL-L-21260 provided satisfactory protection during the 3-year storage test. The experimental VCI oil also provided satisfactory storage protection during this test; however, there was no observable advantage for the VCI oil. The VCI oil had acceptable compatibility with an elastomeric flex ring, metal coupons (except lead), and fuel filters.

  14. Accepters and Rejecters of Counseling.

    ERIC Educational Resources Information Center

    Rose, Harriett A.; Elton, Charles F.

    Personality differences between students who accept or reject proffered counseling assistance were investigated by comparing personality traits of 116 male students at the University of Kentucky who accepted or rejected letters of invitation to group counseling. Factor analysis of Omnibus Personality Inventory (OPI) scores to two groups of 60 and…

  15. Cone penetrometer acceptance test report

    SciTech Connect

    Boechler, G.N.

    1996-09-19

    This Acceptance Test Report (ATR) documents the results of acceptance test procedure WHC-SD-WM-ATR-151. Included in this report is a summary of the tests, the results and issues, the signature and sign- off ATP pages, and a summarized table of the specification vs. ATP section that satisfied the specification.

  16. A Slippery Slope: Children's Perceptions of Their Role in Environmental Preservation in the Peruvian Amazon

    ERIC Educational Resources Information Center

    Galeano, Rebecca

    2013-01-01

    Despite international attention and attempts to preserve the environmental diversity of the Amazon, it is an accepted fact that those who inhabit the forest must be the ones who preserve it. This article presents an analysis of how children in small rural riverine communities along the Amazon understand the importance of environmental preservation…

  17. A sedimentological model of organic-matter preservation and phosphogenesis in the Miocene Monterey Formation at Haskells Beach, Goleta (central California)

    NASA Astrophysics Data System (ADS)

    Laurent, David; de Kaenel, Eric; Spangenberg, Jorge E.; Föllmi, Karl B.

    2015-08-01

    At Haskells Beach, west of Santa Barbara (CA, U.S.A.), the upper part of the Miocene Monterey Formation is predominantly composed of organic-rich mudstone, which is interstratified with phosphatic laminae and lenses. Minor lithologies consist of dolomite, volcanic ash, porcelanite, chert and condensed phosphate. These sediments date from the end of the Serravallian and almost the entire Tortonian (11.05-7.85 Ma) based on calcareous nannofossils and the δ13Corg record, which correlates well with the global record. Sediments have total organic-carbon values between 2.75 and 9.15 wt.% (average value = 6.48 wt.%; n = 61). Rock-Eval analyses show the dominance of type-II kerogen. The sediment accumulation rate varied between 5.9 and 84.7 m/Ma. Correspondingly, organic-carbon accumulation rates range between 0.08 and 1.43 g/cm2/ky (average value = 0.48 g/cm2/ky). Total phosphorus contents in the organic-rich mudstone vary between 0.001 and 3.48 wt.% and Corg/Porg ratios show high values of up to 4727 (average value = 2232), whereas Corg/Ptotal values are low (up to 185; average value = 52). This indicates that early diagenetic organic-matter degradation was a source of phosphate in phosphogenesis. In addition, other sources of phosphate were necessary in order to explain the abundance of phosphate relative to organic matter such as the transfer of dissolved inorganic phosphate into the sediments. Slumps, angular unconformities, erosive surfaces, reworked clasts and nodules, and condensed phosphatic layers suggest that hydrodynamic conditions were important and likely variable, leading to frequent erosion and sediment reworking. Under these circumstances, organic-matter was predominantly delivered during gravity-flow events, which were followed by longer periods of low sediment accumulation and phosphogenesis of the uppermost sediment layer. Associated pore occlusion by phosphate minerals may have considerably enhanced the preservation of organic-matter. During the early

  18. "Thoughts" about Preserving and Empowering Families through Co-Parenting Partnerships.

    ERIC Educational Resources Information Center

    Morris-Bilotti, Sharon

    In the traditional family preservation model, a family's integrity is preserved by keeping children in the care of their immediate or extended families. Family reunification has involved safely returning children to the custody of their families after a period of foster care. However, families are not preserved solely by family members maintaining…

  19. Fertility preservation in Turner syndrome.

    PubMed

    Grynberg, Michaël; Bidet, Maud; Benard, Julie; Poulain, Marine; Sonigo, Charlotte; Cédrin-Durnerin, Isabelle; Polak, Michel

    2016-01-01

    Premature ovarian insufficiency is a relatively rare condition that can appear early in life. In a non-negligible number of cases the ovarian dysfunction results from genetic diseases. Turner syndrome (TS), the most common sex chromosome abnormality in females, is associated with an inevitable premature exhaustion of the follicular stockpile. The possible or probable infertility is a major concern for TS patients and their parents, and physicians are often asked about possible options to preserve fertility. Unfortunately, there are no recommendations on fertility preservation in this group. The severely reduced follicle pool even during prepubertal life represents the major limit for fertility preservation and is the root of numerous questions regarding the competence of gametes or ovarian tissue crybanked. In addition, patients suffering from TS show higher than usual rates of spontaneous abortion, fetal anomaly, and maternal morbidity and mortality, which should be considered at the time of fertility preservation and before reutilization of the cryopreserved gametes. Apart from fulfillment of the desire of becoming genetic parents, TS patients may be potential candidates for egg donation, gestational surrogacy, and adoption. The present review discusses the different options for preserving female fertility in TS and the ethical questions raised by these approaches. PMID:26677790

  20. Acceptance of Swedish e-health services

    PubMed Central

    Jung, Mary-Louise; Loria, Karla

    2010-01-01

    Objective: To investigate older people’s acceptance of e-health services, in order to identify determinants of, and barriers to, their intention to use e-health. Method: Based on one of the best-established models of technology acceptance, Technology Acceptance Model (TAM), in-depth exploratory interviews with twelve individuals over 45 years of age and of varying backgrounds are conducted. Results: This investigation could find support for the importance of usefulness and perceived ease of use of the e-health service offered as the main determinants of people’s intention to use the service. Additional factors critical to the acceptance of e-health are identified, such as the importance of the compatibility of the services with citizens’ needs and trust in the service provider. Most interviewees expressed positive attitudes towards using e-health and find these services useful, convenient, and easy to use. Conclusion: E-health services are perceived as a good complement to traditional health care service delivery, even among older people. These people, however, need to become aware of the e-health alternatives that are offered to them and the benefits they provide. PMID:21289860

  1. Honoring Our Hospital's History: A Preservation and Digitization Initiative.

    PubMed

    Macdonald, Kerry; Bass, Jordan; Maloney, Toby

    2016-01-01

    There is limited literature on hospital archives projects. Hospitals understandably have a strong focus on patient care, but there is still a critical need to keep institutional archives. Among their many uses, institutional archives preserve corporate memory, provide evidence of interactions with community, and assist in contemporary decision making. This column describes a university-hospital partnership to undertake a one-year project to preserve, detail, and digitize ten boxes, or approximately 3.8 meters, of materials dating from 1980 to 2006. This project serves as a model for other hospital or health care facilities wanting to preserve and more actively engage with their archival collections. PMID:27391184

  2. Preserving the Context of Science Data

    NASA Astrophysics Data System (ADS)

    Janée, G.; Frew, J.

    2008-12-01

    Preserving any type of digital information requires preserving both the "bits" comprising the information, and sufficient context (metadata) to support interpreting the bits in the future. Unfortunately, this context is often implicit or embedded in organizations (e.g., communities of practice) or artifacts (e.g., computing platforms) that are not as survivable as the information itself. Therefore, digital preservation must explicitly preserve context. Two necessary components of digital scientific information context are formats and provenance. Formats describe the syntax and low-level semantics of digital information objects (e.g., files). The library community has promulgated format registries (e.g, PRONOM, GDFR, digitalpreservation.gov) that allow archival objects to refer to format definitions using standardized persistent identifiers. Format registries maintain this context separately from the information that references it, but make no archival guarantees about the context's survival. Meanwhile, the scientific community has focused on capturing the provenance of scientific information, typically as a formal workflow specification of the processing steps that created the information. Unfortunately, there is as yet no standard for scientific workflows, nor any guarantee that a specification that can reproduce information is sufficient for understanding it. We describe new technologies that may prove a better fit for preserving scientific information context. The National Geospatial Digital Archive (NGDA) data model represents formats as archival objects containing specifications, software implementations, and other documentation. A format registry is simply an archive that happens to hold archival objects representing formats. Both format and provenance relationships are represented by typed references. Any archival object may reference any other object for its interpretation: the referenced object may be a "file format" object or an object containing dataset

  3. Clathrate hydrates for ozone preservation.

    PubMed

    Muromachi, Sanehiro; Ohmura, Ryo; Takeya, Satoshi; Mori, Yasuhiko H

    2010-09-01

    We report the experimental evidence for the preservation of ozone (O(3)) encaged in a clathrate hydrate. Although ozone is an unstable substance and is apt to decay to oxygen (O(2)), it may be preserved for a prolonged time if it is encaged in hydrate cavities in the form of isolated molecules. This possibility was assessed using a hydrate formed from an ozone + oxygen gas mixture coexisting with carbon tetrachloride or xenon. Each hydrate sample was stored in an air-filled container at atmospheric pressure and a constant temperature in the range between -20 and 2 degrees C and was continually subjected to iodometric measurements of its fractional ozone content. Such chronological measurements and structure analysis using powder X-ray diffraction have revealed that ozone can be preserved in a hydrate-lattice structure for more than 20 days at a concentration on the order of 0.1% (hydrate-mass basis). PMID:20707330

  4. Preservation at Stony Brook. Preservation Planning Program. Study Report.

    ERIC Educational Resources Information Center

    Cook, Donald C.; And Others

    This final report is a product of a Preservation Planning Program (PPP) self-study conducted by the State University of New York (SUNY), Stony Brook, working with the Association of Research Libraries' (ARL) Office of Management Studies (OMS). The PPP is designed to put self-help tools into the hands of library staff responsible for developing…

  5. Accepted scientific research works (abstracts).

    PubMed

    2014-01-01

    These are the 39 accepted abstracts for IAYT's Symposium on Yoga Research (SYR) September 24-24, 2014 at the Kripalu Center for Yoga & Health and published in the Final Program Guide and Abstracts. PMID:25645134

  6. L-286 Acceptance Test Record

    SciTech Connect

    HARMON, B.C.

    2000-01-14

    This document provides a detailed account of how the acceptance testing was conducted for Project L-286, ''200E Area Sanitary Water Plant Effluent Stream Reduction''. The testing of the L-286 instrumentation system was conducted under the direct supervision

  7. Cryobiological preservation of Drosophila embryos

    SciTech Connect

    Mazur, P.; Schreuders, P.D.; Cole, K.W.; Hall, J.W. ); Mahowald, A.P. )

    1992-12-18

    The inability to cryobiologically preserve the fruit fly Drosophila melanogaster has required that fly stocks be maintained by frequent transfer of adults. This method is costly in terms of time and can lead to loss of stocks. Traditional slow freezing methods do not succeed because the embryos are highly sensitive to chilling. With the procedures described here, 68 percent of precisely staged 15-hour Oregon R (wild-type) embryos hatch after vitrification at -205[degree]C, and 40 percent of the resulting larvae develop into normal adult flies. These embryos are among the most complex organisms successfully preserved by cryobiology.

  8. Conceptual and Adoption of Technology Acceptance Model in Digital Information Resources Usage by Undergraduates: Implication to Higher Institutions Education in Delta and Edo of Nigeria

    ERIC Educational Resources Information Center

    Urhiewhu, Lucky Oghenetega; Emojorho, Daniel

    2015-01-01

    The article paper was on conceptual and theoretical framework of digital information resources usage by undergraduates: Implication to higher institutions education in Delta and Edo of Nigeria. It revealed the concept of digital information resources [DIRs] and model theory that related to the study. Finding shows that DIRs are use to low extent…

  9. Protective Effect of Antiapoptosis Potency of Prolonged Preservation by Desiccation Using High-Pressure Carbon Monoxide on Isolated Rabbit Hearts.

    PubMed

    Zhou, P Y; Zhang, Z; Guo, Y L; Xiao, Z Z; Zhu, P; Mai, M J; Zheng, S Y

    2015-11-01

    Heart transplantation has been widely accepted as a therapy for end-stage heart failure. Mitigation of ischemia-reperfusion injury by inhibiting the apoptotic process plays an important role in organ transplantation. Desiccation using high-pressure carbon monoxide (CO) is a new method of preserving donor hearts; however, its mechanism of antiapoptosis remains unclear. This study was intended to elucidate the efficacy and mechanism of preservation by desiccation for 18 hours using high-pressure CO on myocardial apoptosis. Rabbit heterotopic abdominal cardiac transplantation models were established. New Zealand rabbits were divided randomly into 3 groups: naive group (n = 16), HTK group (n = 16), and desiccation using high-pressure CO group (n = 16). The donor hearts of the naive group were transplanted immediately after being extracted. In the HTK group, the donor hearts were extracted and steeped in 4°C HTK cardioplegic solution for 18 hours and then transplanted; in the desiccation using high-pressure CO group, the donor hearts were extracted and exposed to a gas mixture (Po2 = 3200 hPa, Pco = 800 hPa) in the chamber before being preserved in a refrigerator at 4°C for 18 hours and then transplanted. Apoptotic cardiomyocytes were detected using TUNEL technique and histopathology was performed by hematoxylin-eosin staining. The expression of the ratio of Bcl-2/Bax and caspase-3 proteins was detected using the Western blot method. These findings suggest that compared with traditional HTK preservation, preservation by desiccation using high-pressure CO could alleviate rabbits' myocardial histopathology and apoptosis induced by ischemia-reperfusion injury through adjusting the ratio of Bcl-2/Bax protein expression, thus resulting in the reduction of expression of caspase-3. PMID:26680086

  10. Preservation versus non-preservation of mitral valve apparatus during mitral valve replacement: a meta-analysis of 3835 patients

    PubMed Central

    Sá, Michel Pompeu Barros de Oliveira; Ferraz, Paulo Ernando; Escobar, Rodrigo Renda; Martins, Wendell Santos; de Araújo e Sá, Frederico Browne Correia; Lustosa, Pablo César; Vasconcelos, Frederico Pires; Lima, Ricardo Carvalho

    2012-01-01

    Resection of the chordopapillary apparatus during mitral valve replacement has been associated with a negative impact on survival. Mitral valve replacement with the preservation of the mitral valve apparatus has been associated with better outcomes, but surgeons remain refractory to its use. To determine if there is any real difference in preservation vs non-preservation of mitral valve apparatus during mitral valve replacement in terms of outcomes, we performed a systematic review and meta-analysis using MEDLINE, EMBASE, CENTRAL/CCTR, SciELO, LILACS, Google Scholar and reference lists of relevant articles to search for clinical studies that compared outcomes (30-day mortality, postoperative low cardiac output syndrome or 5-year mortality) between preservation vs non-preservation during mitral valve replacement from 1966 to 2011. The principal summary measures were odds ratios (ORs) with 95% confidence interval and P-values (that will be considered statistically significant when <0.05). The ORs were combined across studies using a weighted DerSimonian–Laird random-effects model. The meta-analysis was completed using the software Comprehensive Meta-Analysis version 2 (Biostat Inc., Englewood, NJ, USA). Twenty studies (3 randomized and 17 non-randomized) were identified and included a total of 3835 patients (1918 for mitral valve replacement preservation and 1917 for mitral valve replacement non-preservation). There was significant difference between mitral valve replacement preservation and mitral valve replacement non-preservation groups in the risk of 30-day mortality (OR 0.418, P <0.001), postoperative low cardiac output syndrome (OR 0.299, P <0.001) or 5-year mortality (OR 0.380, P <0.001). No publication bias or important heterogeneity of effects on any outcome was observed. In conclusion, we found evidence that argues in favour of the preservation of mitral valve apparatus during mitral valve replacement. PMID:23027596

  11. Preservation of Long-Term Memory and Synaptic Plasticity Despite Short-Term Impairments in the Tc1 Mouse Model of Down Syndrome

    ERIC Educational Resources Information Center

    Morice, Elise; Andreae, Laura C.; Cooke, Sam F.; Vanes, Lesley; Fisher, Elizabeth M. C.; Tybulewicz, Victor L. J.; Bliss, Timothy V. P.

    2008-01-01

    Down syndrome (DS) is a genetic disorder arising from the presence of a third copy of the human chromosome 21 (Hsa21). Recently, O'Doherty and colleagues in an earlier study generated a new genetic mouse model of DS (Tc1) that carries an almost complete Hsa21. Since DS is the most common genetic cause of mental retardation, we have undertaken a…

  12. Evaluating innovation. Part 1: The concept of progressive scholarly acceptance.

    PubMed

    Schnurman, Zane; Kondziolka, Douglas

    2016-01-01

    Understanding how the relevant medical community accepts new therapies is vital to patients, physicians, and society. Increasingly, focus is placed on how medical innovations are evaluated. But recognizing when a treatment has become accepted practice-essentially, acceptance by the scientific community-remains a challenge and a barrierto investigating treatment development. This report aims to demonstrate the theory, method, and limitations of a model for measuring a new metric that the authors term "progressive scholarly acceptance." A model was developed to identify when the scientific community has accepted an innovation, by observing when researchers have moved beyond the initial study of efficacy. This model could enable further investigations into the methods and influences of treatment development. PMID:26252458

  13. Highly accurate stability-preserving optimization of the Zener viscoelastic model, with application to wave propagation in the presence of strong attenuation

    NASA Astrophysics Data System (ADS)

    Blanc, Émilie; Komatitsch, Dimitri; Chaljub, Emmanuel; Lombard, Bruno; Xie, Zhinan

    2016-04-01

    This paper concerns the numerical modelling of time-domain mechanical waves in viscoelastic media based on a generalized Zener model. To do so, classically in the literature relaxation mechanisms are introduced, resulting in a set of the so-called memory variables and thus in large computational arrays that need to be stored. A challenge is thus to accurately mimic a given attenuation law using a minimal set of relaxation mechanisms. For this purpose, we replace the classical linear approach of Emmerich & Korn with a nonlinear optimization approach with constraints of positivity. We show that this technique is more accurate than the linear approach. Moreover, it ensures that physically meaningful relaxation times that always honour the constraint of decay of total energy with time are obtained. As a result, these relaxation times can always be used in a stable way in a modelling algorithm, even in the case of very strong attenuation for which the classical linear approach may provide some negative and thus unusable coefficients.

  14. Preservation and Archives in Vietnam.

    ERIC Educational Resources Information Center

    Henchy, Judith

    This report, based on visits to Vietnamese libraries and archives between 1987 and 1997, examines the largely unexplored corpus of Vietnamese textual resources in research institutions and libraries there and elsewhere, the associated problems of bibliographic control, and issues of preservation. The following topics are addressed: the history of…

  15. Investigating Students' Usage and Acceptance of Electronic Books

    ERIC Educational Resources Information Center

    Sieche, Susan; Krey, Birte; Bastiaens, Theo

    2013-01-01

    The purpose of this study is to investigate students' usage and acceptance of electronic books. Factors correlating with students' attitude towards e-books were examined using the Technology Acceptance Model (Davis, Bagozzi, & Warshaw 1989). A questionnaire was administered online for students at University of Hagen. Results indicate…

  16. Technology Acceptance of Electronic Medical Records by Nurses

    ERIC Educational Resources Information Center

    Stocker, Gary

    2010-01-01

    The purpose of this study was to evaluate the Technology Acceptance Model's (TAM) relevance of the intention of nurses to use electronic medical records in acute health care settings. The basic technology acceptance research of Davis (1989) was applied to the specific technology tool of electronic medical records (EMR) in a specific setting…

  17. Technology Acceptance among Pre-Service Teachers: Does Gender Matter?

    ERIC Educational Resources Information Center

    Teo, Timothy; Fan, Xitao; Du, Jianxia

    2015-01-01

    This study examined possible gender differences in pre-service teachers' perceived acceptance of technology in their professional work under the framework of the technology acceptance model (TAM). Based on a sample of pre-service teachers, a series of progressively more stringent measurement invariance tests (configural, metric, and scalar…

  18. The role of spatial information in the preservation of the shrimp nursery function of mangroves: a spatially explicit bio-economic model for the assessment of land use trade-offs.

    PubMed

    Zavalloni, Matteo; Groeneveld, Rolf A; van Zwieten, Paul A M

    2014-10-01

    Conversion to aquaculture affects the provision of important ecosystem services provided by mangrove ecosystems, and this effect depends strongly on the location of the conversion. We introduce in a bio-economic mathematical programming model relevant spatial elements that affect the provision of the nursery habitat service of mangroves: (1) direct or indirect connection of mangroves to watercourses; (2) the spatial allocation of aquaculture ponds; and (3) the presence of non-linear relations between mangrove extent and juvenile recruitment to wild shrimp populations. By tracing out the production possibilities frontier of wild and cultivated shrimp, the model assesses the role of spatial information in the trade-off between aquaculture and the nursery habitat function using spatial elements relevant to our model of a mangrove area in Ca Mau Province, Viet Nam. Results show that where mangrove forests have to coexist with shrimp aquaculture ponds, the inclusion of specific spatial information on ecosystem functions in considerations of land allocation can achieve aquaculture benefits while largely preserving the economic benefits generated by the nursery habitat function. However, if spatial criteria are ignored, ill-advised land allocation decisions can easily lead to a collapse of the mangrove's nursery function. PMID:24833524

  19. Consumer attitudes toward new technique for preserving organic meat using herbs and berries.

    PubMed

    Haugaard, Pernille; Hansen, Flemming; Jensen, Martin; Grunert, Klaus G

    2014-01-01

    This study aims to explore consumers' attitude toward a new preservation technique using herbs and berries in organic meat production, which enables to minimize the amount of chemical additives and to reduce the salt content in meat products. Consumer acceptance of the preservation technique using herbs and berries and intention to purchase products preserved with herbs and berries were investigated through a qualitative approach by means of three focus groups. In general, most participants were positive toward the preservation technique using herbs and berries and there were only few concerns related to the technique. Concerns were related not as much to the technique but more to the products. Four factors seem important in this relation: shelf life, taste, appearance and texture. The intention to purchase products preserved with herbs and berries is generally high, but is dependent on taste and appearance of the products, the price and information level. PMID:23896146

  20. The PACT study protocol: a time series study investigating the impact, acceptability and cost of an integrated model for psychosocial screening, care and treatment of patients with urological and head and neck cancers

    PubMed Central

    Girgis, Afaf; Kelly, Brian; Boyes, Allison; Haas, Marion; Viney, Rosalie; Descallar, Joseph; Candler, Hayley; Bellamy, Douglas; Proietto, Anthony

    2014-01-01

    Introduction While there is good evidence of the effectiveness of a variety of interventions and services to prevent and/or relieve distress experienced by people affected by cancer, much of this psychosocial morbidity is undetected and untreated, with consequent exacerbated suffering, decreased satisfaction with care, impaired adherence to treatment regimens and poorer morbidity and mortality outcomes. The objective of this study is to develop, implement and assess the impact, acceptability and cost of an integrated, patient-centred Psychosocial Assessment, Care and Treatment (PACT) model of care for patients with urological and head and neck cancers. Methods and analysis A time series research design will be used to test the PACT model of care, newly introduced in an Australian tertiary hospital. The primary outcome is system-level impact, assessed through audit of patients’ medical records and Medicare claims for follow-up care. The secondary outcomes are impact of the model on patients' experience and healthcare professionals’ (HCPs) knowledge and confidence, assessed via patient and HCP surveys at baseline and at follow-up. Acceptability of the intervention will be assessed through HCP interviews at follow-up, and cost will be assessed from Medicare and Pharmaceutical Benefits Scheme claims information and information logged pertaining to intervention activities (eg, time spent by the newly appointed psycho-oncology staff in direct patient contact, providing training sessions, engaging in case review) and their associated costs (eg, salaries, training materials and videoconferencing). Ethics and dissemination Ethics approval was obtained from the Human Research Ethics Committees of Hunter New England Local Health District and the University of NSW. Results The results will be widely disseminated to the funding body and through peer-reviewed publications, HCP and consumer publications, oncology conferences and meetings. Trial registration The study is

  1. Preservation of forcing signals in shallow water carbonate sediments

    NASA Astrophysics Data System (ADS)

    Hill, Jon; Wood, Rachel; Curtis, Andrew; Tetzlaff, Daniel M.

    2012-11-01

    No consensus has been reached on whether the metre-scale cycles that commonly occur in peritidal carbonates are predominately a product of external relative sea-level variations (allocycles) or an intrinsic property of carbonate production generated via the interaction of non-linear processes (autocycles). For any forcing signal such as eustatic sea-level change, to be detectable in stratigraphy its effects must be preserved. Here, a deterministic, three-dimensional geological process model is used to explore how such cycles are preserved in the geological record in the presence of autocyclic processes. Each simulation produced cycle thickness distributions that are statistically indistinguishable from a theoretical Poisson process, regardless of whether auto- or allo-cycles dominated. Spectral analysis of depositional time series constructed from idealised geological sections showed that all detectable signals occurred within the Milankovitch forcing frequency bands, even when no Milankovitch forcing was present. Thus, it is deduced that from any geological section alone, external forcing signals are detectable but are not distinguishable from autocyclically produced signals. Interestingly, there is no correlation between the percentage of sediment preserved and the accuracy with which signals are detectable in the preserved sediment: in some model realisations, even with preservation as low as 40%, the correct forcing signal can be detected accurately while, conversely, sections with preservation as high as 90% can have poor signal preservation. The reverse can also be true in other models. It is therefore concluded that distinguishing allocyclic and autocyclic forcing in shallow marine or peritidal carbonate successions is likely to be extremely difficult except in cases of extraordinary sedimentary preservation and dating accuracy.

  2. Hybrid Food Preservation Program Improves Food Preservation and Food Safety Knowledge

    ERIC Educational Resources Information Center

    Francis, Sarah L.

    2014-01-01

    The growing trend in home food preservation raises concerns about whether the resulting food products will be safe to eat. The increased public demand for food preservation information led to the development of the comprehensive food preservation program, Preserve the Taste of Summer (PTTS). PTTS is a comprehensive hybrid food preservation program…

  3. Amniotic Fluid-Derived Mesenchymal Stem Cells Prevent Fibrosis and Preserve Renal Function in a Preclinical Porcine Model of Kidney Transplantation

    PubMed Central

    Baulier, Edouard; Favreau, Frederic; Le Corf, Amélie; Jayle, Christophe; Schneider, Fabrice; Goujon, Jean-Michel; Feraud, Olivier; Bennaceur-Griscelli, Annelise; Turhan, Ali G.

    2014-01-01

    It is well known that ischemia/reperfusion injuries strongly affect the success of human organ transplantation. Development of interstitial fibrosis and tubular atrophy is the main deleterious phenomenon involved. Stem cells are a promising therapeutic tool already validated in various ischemic diseases. Amniotic fluid-derived mesenchymal stem cells (af-MSCs), a subpopulation of multipotent cells identified in amniotic fluid, are known to secrete growth factors and anti-inflammatory cytokines. In addition, these cells are easy to collect, present higher proliferation and self-renewal rates compared with other adult stem cells (ASCs), and are suitable for banking. Consequently, af-MSCs represent a promising source of stem cells for regenerative therapies in humans. To determine the efficiency and the safety of af-MSC infusion in a preclinical porcine model of renal autotransplantation, we injected autologous af-MSCs in the renal artery 6 days after transplantation. The af-MSC injection improved glomerular and tubular functions, leading to full renal function recovery and abrogated fibrosis development at 3 months. The strong proof of concept generated by this translational porcine model is a first step toward evaluation of af-MSC-based therapies in human kidney transplantation. PMID:24797827

  4. Effects of Roux-en-Y gastric bypass on energy and glucose homeostasis are preserved in two mouse models of functional glucagon-like peptide-1 deficiency.

    PubMed

    Mokadem, Mohamad; Zechner, Juliet F; Margolskee, Robert F; Drucker, Daniel J; Aguirre, Vincent

    2014-04-01

    Glucagon-like peptide-1 (GLP-1) secretion is greatly enhanced after Roux-en-Y gastric bypass (RYGB). While intact GLP-1exerts its metabolic effects via the classical GLP-1 receptor (GLP-1R), proteolytic processing of circulating GLP-1 yields metabolites such as GLP-1(9-36)amide/GLP-1(28-36)amide, that exert similar effects independent of the classical GLP-1R. We investigated the hypothesis that GLP-1, acting via these metabolites or through its known receptor, is required for the beneficial effects of RYGB using two models of functional GLP-1 deficiency - α-gustducin-deficient (α-Gust (-/-)) mice, which exhibit attenuated nutrient-stimulated GLP-1 secretion, and GLP-1R-deficient mice. We show that the effect of RYGB to enhance glucose-stimulated GLP-1 secretion was greatly attenuated in α-Gust (-/-) mice. In both genetic models, RYGB reduced body weight and improved glucose homeostasis to levels observed in lean control mice. Therefore, GLP-1, acting through its classical GLP-1R or its bioactive metabolites, does not seem to be involved in the effects of RYGB on body weight and glucose homeostasis. PMID:24634822

  5. 17β-Estradiol eye drops protect the retinal ganglion cell layer and preserve visual function in an in vivo model of glaucoma

    PubMed Central

    Tatrai, Katalin Prokai; Xin, Hua; Nguyen, Vien; Szarka, Szabolcs; Blazics, Balazs; Prokai, Laszlo; Koulen, Peter

    2013-01-01

    Neuroprotection in glaucoma as a curative strategy complementary to current therapies to lower intraocular pressure (IOP) is highly desirable. This study was designed to investigate neuroprotection by 17β-estradiol (E2) to prevent retinal ganglion cell (RGC) death in a glaucoma model of surgically elevated IOP in rats. We found that daily treatment with E2 containing eye drops resulted in significant E2 concentration in the retina with concomitant profound neuroprotective therapeutic benefits, even in the presence of continually elevated IOP. The number of apoptotic cells in the RGC layer was significantly decreased in the E2-treated group, when compared to the vehicle-treated controls. Deterioration in visual acuity in these animals was also markedly prevented. Using mass spectrometry-based proteomics, beneficial changes in the expression of several proteins implicated in the maintenance of retinal health were also found in the retina of E2-treated animals. On the other hand, systemic side-effects could not be avoided with the eye drops, as confirmed by the measured high circulating estrogen levels and through the assessment of the uterus representing a typical hormone-sensitive peripheral organ. Collectively, the demonstrated significant neuroprotective effect of topical E2 in the selected animal model of glaucoma provides a clear rationale for further studies aiming at targeting E2 into the eye while avoiding systemic E2 exposure to diminish undesirable off target side-effects. PMID:23841874

  6. Factors Affecting Acceptance & Use of ReWIND: Validating the Extended Unified Theory of Acceptance and Use of Technology

    ERIC Educational Resources Information Center

    Nair, Pradeep Kumar; Ali, Faizan; Leong, Lim Chee

    2015-01-01

    Purpose: This study aims to explain the factors affecting students' acceptance and usage of a lecture capture system (LCS)--ReWIND--in a Malaysian university based on the extended unified theory of acceptance and use of technology (UTAUT2) model. Technological advances have become an important feature of universities' plans to improve the…

  7. VEGFR tyrosine kinase inhibitor II (VRI) induced vascular insufficiency in zebrafish as a model for studying vascular toxicity and vascular preservation

    SciTech Connect

    Li, Shang; Dang, Yuan Ye; Oi Lam Che, Ginny; Kwan, Yiu Wa; Chan, Shun Wan; Leung, George Pak Heng; Lee, Simon Ming Yuen; Hoi, Maggie Pui Man

    2014-11-01

    In ischemic disorders such as chronic wounds and myocardial ischemia, there is inadequate tissue perfusion due to vascular insufficiency. Besides, it has been observed that prolonged use of anti-angiogenic agents in cancer therapy produces cardiovascular toxicity caused by impaired vessel integrity and regeneration. In the present study, we used VEGFR tyrosine kinase inhibitor II (VRI) to chemically induce vascular insufficiency in zebrafish in vivo and human umbilical vein endothelial cells (HUVEC) in vitro to further study the mechanisms of vascular morphogenesis in these pathological conditions. We also explored the possibility of treating vascular insufficiency by enhancing vascular regeneration and repair with pharmacological intervention. We observed that pretreatment of VRI induced blood vessel loss in developing zebrafish by inhibiting angiogenesis and increasing endothelial cell apoptosis, accompanied by down-regulation of kdr, kdrl and flt-1 genes expression. The VRI-induced blood vessel loss in zebrafish could be restored by post-treatment of calycosin, a cardiovascular protective isoflavone. Similarly, VRI induced cytotoxicity and apoptosis in HUVEC which could be rescued by calycosin post-treatment. Further investigation of the underlying mechanisms showed that the PI3K/AKT/Bad cell survival pathway was a main contributor of the vascular regenerative effect of calycosin. These findings indicated that the cardiovascular toxicity in anti-angiogenic therapy was mainly caused by insufficient endothelial cell survival, suggesting its essential role in vascular integrity, repair and regeneration. In addition, we showed that VRI-induced blood vessel loss in zebrafish represented a simple and effective in vivo model for studying vascular insufficiency and evaluating cancer drug vascular toxicities. - Highlights: • In vivo VRI model • Rescue effects of calycosin • Calycosin EC survival pathways.

  8. User acceptance of mobile commerce: an empirical study in Macau

    NASA Astrophysics Data System (ADS)

    Lai, Ivan K. W.; Lai, Donny C. F.

    2014-06-01

    This study aims to examine the positive and negative factors that can significantly explain user acceptance of mobile commerce (m-commerce) in Macau. A technology acceptance model for m-commerce with five factors is constructed. The proposed model is tested using data collected from 219 respondents. Confirmatory factor analysis is performed to examine the reliability and validity of the model, and structural equation modelling is performed to access the relationship between behaviour intention and each factor. The acceptance of m-commerce is influenced by factors including performance expectancy, social influence, facilitating conditions and privacy concern; while effort expectancy is insignificant in this case. The results of the study are useful for m-commerce service providers to adjust their strategies for promoting m-commerce services. This study contributes to the practice by providing a user technology acceptance model for m-commerce that can be used as a foundation for future research.

  9. Defining acceptable conditions in wilderness

    NASA Astrophysics Data System (ADS)

    Roggenbuck, J. W.; Williams, D. R.; Watson, A. E.

    1993-03-01

    The limits of acceptable change (LAC) planning framework recognizes that forest managers must decide what indicators of wilderness conditions best represent resource naturalness and high-quality visitor experiences and how much change from the pristine is acceptable for each indicator. Visitor opinions on the aspects of the wilderness that have great impact on their experience can provide valuable input to selection of indicators. Cohutta, Georgia; Caney Creek, Arkansas; Upland Island, Texas; and Rattlesnake, Montana, wilderness visitors have high shared agreement that littering and damage to trees in campsites, noise, and seeing wildlife are very important influences on wilderness experiences. Camping within sight or sound of other people influences experience quality more than do encounters on the trails. Visitors’ standards of acceptable conditions within wilderness vary considerably, suggesting a potential need to manage different zones within wilderness for different clientele groups and experiences. Standards across wildernesses, however, are remarkably similar.

  10. From requirements to acceptance tests

    NASA Technical Reports Server (NTRS)

    Baize, Lionel; Pasquier, Helene

    1993-01-01

    From user requirements definition to accepted software system, the software project management wants to be sure that the system will meet the requirements. For the development of a telecommunication satellites Control Centre, C.N.E.S. has used new rules to make the use of tracing matrix easier. From Requirements to Acceptance Tests, each item of a document must have an identifier. A unique matrix traces the system and allows the tracking of the consequences of a change in the requirements. A tool has been developed, to import documents into a relational data base. Each record of the data base corresponds to an item of a document, the access key is the item identifier. Tracing matrix is also processed, providing automatically links between the different documents. It enables the reading on the same screen of traced items. For example one can read simultaneously the User Requirements items, the corresponding Software Requirements items and the Acceptance Tests.

  11. Role of oil extract of garlic (Allium sativum Linn.) on intestinal transference of calcium and its possible correlation with preservation of skeletal health in an ovariectomized rat model of osteoporosis.

    PubMed

    Mukherjee, Maitrayee; Das, Asankur Sekhar; Das, Dolan; Mukherjee, Sandip; Mitra, Smita; Mitra, Chandan

    2006-05-01

    The present study was undertaken to examine the effects of an oil extract of garlic on the in vivo intestinal transference of calcium, and also to verify its role in maintaining the bone mineral content and bone tensile strength in an ovariectomized rat model of osteoporosis. The results suggest that, in this experimental model, oil extract of garlic promotes intestinal transference of calcium by modulating the activities of both intestinal alkaline phosphatase and Ca(2+) activated ATPase. Also the observed low bone mineral content and low bone tensile strength in these rats were significantly restored by garlic oil supplementation. Further, garlic oil supplementation was able to revive partially the bilateral ovariectomy-induced decrease in the serum estrogen titer. The serum parathyroid hormone level, however, was found unaltered in these rats. The garlic oil supplemented partial recovery in serum estrogen titer in bilaterally ovariectomized rat was found to be persistently associated with enhanced calcium transference and better preservation of bone mineral content. The results of this study propose that the phytoestrogenic efficacy of an oil extract of garlic prevents ovarian hormone deficiency induced bone mineral loss possibly by promoting intestinal transference of calcium through the partial revival of the serum estrogen titer. PMID:16619371

  12. The MAGNEX large acceptance spectrometer

    SciTech Connect

    Cavallaro, M.; Cappuzzello, F.; Cunsolo, A.; Carbone, D.; Foti, A.

    2010-03-01

    The main features of the MAGNEX large acceptance magnetic spectrometer are described. It has a quadrupole + dipole layout and a hybrid detector located at the focal plane. The aberrations due to the large angular (50 msr) and momentum (+- 13%) acceptance are reduced by an accurate hardware design and then compensated by an innovative software ray-reconstruction technique. The obtained resolution in energy, angle and mass are presented in the paper. MAGNEX has been used up to now for different experiments in nuclear physics and astrophysics confirming to be a multipurpose device.

  13. Preserved entropy and fragile magnetism

    NASA Astrophysics Data System (ADS)

    Canfield, Paul C.; Bud’ko, Sergey L.

    2016-08-01

    A large swath of quantum critical and strongly correlated electron systems can be associated with the phenomena of preserved entropy and fragile magnetism. In this overview we present our thoughts and plans for the discovery and development of lanthanide and transition metal based, strongly correlated systems that are revealed by suppressed, fragile magnetism, quantum criticality, or grow out of preserved entropy. We will present and discuss current examples such as YbBiPt, YbAgGe, YbFe2Zn20, PrAg2In, BaFe2As2, CaFe2As2, LaCrSb3 and LaCrGe3 as part of our motivation and to provide illustrative examples.

  14. Preserved entropy and fragile magnetism.

    PubMed

    Canfield, Paul C; Bud'ko, Sergey L

    2016-08-01

    A large swath of quantum critical and strongly correlated electron systems can be associated with the phenomena of preserved entropy and fragile magnetism. In this overview we present our thoughts and plans for the discovery and development of lanthanide and transition metal based, strongly correlated systems that are revealed by suppressed, fragile magnetism, quantum criticality, or grow out of preserved entropy. We will present and discuss current examples such as YbBiPt, YbAgGe, YbFe2Zn20, PrAg2In, BaFe2As2, CaFe2As2, LaCrSb3 and LaCrGe3 as part of our motivation and to provide illustrative examples. PMID:27377181

  15. Technical Information/Website Preservation

    NASA Technical Reports Server (NTRS)

    PintoRey, Christian R.

    2010-01-01

    This document reviews the work of the author in NASA's Motivating Undergraduates in Science and Technology (MUST) internship. The intern worked on the Space Shuttles hydraulic systems (i.e., Auxiliary Power Units (APU's) and Hydraulic Pump Units (HPU's)), and website preservation of the hydraulic technology captured in websites relating to the coming.the Space Shuttle Retirement. Several figures and pictures show an overview of the orbiter's hydraulic systems

  16. An Invariant-Preserving ALE Method for Solids under Extreme Conditions

    SciTech Connect

    Sambasivan, Shiv Kumar; Christon, Mark A

    2012-07-17

    We are proposing a fundamentally new approach to ALE methods for solids undergoing large deformation due to extreme loading conditions. Our approach is based on a physically-motivated and mathematically rigorous construction of the underlying Lagrangian method, vector/tensor reconstruction, remapping, and interface reconstruction. It is transformational because it deviates dramatically from traditionally accepted ALE methods and provides the following set of unique attributes: (1) a three-dimensional, finite volume, cell-centered ALE framework with advanced hypo-/hyper-elasto-plastic constitutive theories for solids; (2) a new physically and mathematically consistent reconstruction method for vector/tensor fields; (3) advanced invariant-preserving remapping algorithm for vector/tensor quantities; (4) moment-of-fluid (MoF) interface reconstruction technique for multi-material problems with solids undergoing large deformations. This work brings together many new concepts, that in combination with emergent cell-centered Lagrangian hydrodynamics methods will produce a cutting-edge ALE capability and define a new state-of-the-art. Many ideas in this work are new, completely unexplored, and hence high risk. The proposed research and the resulting algorithms will be of immediate use in Eulerian, Lagrangian and ALE codes under the ASC program at the lab. In addition, the research on invariant preserving reconstruction/remap of tensor quantities is of direct interest to ongoing CASL and climate modeling efforts at LANL. The application space impacted by this work includes Inertial Confinement Fusion (ICF), Z-pinch, munition-target interactions, geological impact dynamics, shock processing of powders and shaped charges. The ALE framework will also provide a suitable test-bed for rapid development and assessment of hypo-/hyper-elasto-plastic constitutive theories. Today, there are no invariant-preserving ALE algorithms for treating solids with large deformations. Therefore

  17. Phase-preserved optical elevator

    PubMed Central

    Luo, Yuan; Zhang, Baile; Han, Tiancheng; Chen, Zhi; Duan, Yubo; Chu, Chia-Wei; Barbastathis, George; Qiu, Cheng Wei

    2013-01-01

    The unique superiority of transformation optics devices designed from coordinate transformation is their capability of recovering both ray trajectory and optical path length in light manipulation. However, very few experiments have been done so far to verify this dual-recovery property from viewpoints of both ray trajectory and optical path length simultaneously. The experimental difficulties arise from the fact that most previous optical transformation optics devices only work at the nano-scale; the lack of intercomparison between data from both optical path length and ray trajectory measurement in these experiments obscured the fact that the ray path was subject to a subwavelength lateral shift that was otherwise not easily perceivable and, instead, was pointed out theoretically [B. Zhang et al. Phys. Rev. Lett. 104, 233903, (2010)]. Here, we use a simple macroscopic transformation optics device of phase-preserved optical elevator, which is a typical birefringent optical phenomenon that can virtually lift an optical image by a macroscopic distance, to demonstrate decisively the unique optical path length preservation property of transformation optics. The recovery of ray trajectory is first determined with no lateral shift in the reflected ray. The phase preservation is then verified with incoherent white-light interferometry without ambiguity and phase unwrapping. PMID:23546046

  18. Nitrogen trailer acceptance test report

    SciTech Connect

    Kostelnik, A.J.

    1996-02-12

    This Acceptance Test Report documents compliance with the requirements of specification WHC-S-0249. The equipment was tested according to WHC-SD-WM-ATP-108 Rev.0. The equipment being tested is a portable contained nitrogen supply. The test was conducted at Norco`s facility.

  19. Helping Our Children Accept Themselves.

    ERIC Educational Resources Information Center

    Gamble, Mae

    1984-01-01

    Parents of a child with muscular dystrophy recount their reactions to learning of the diagnosis, their gradual acceptance, and their son's resistance, which was gradually lessened when he was provided with more information and treated more normally as a member of the family. (CL)

  20. Acceptability of Treatments for Plagiarism

    ERIC Educational Resources Information Center

    Carter, Stacy L.; Punyanunt-Carter, Narissra Maria

    2007-01-01

    This study focused on various treatments for addressing incidents of plagiarism by college students. College students rated the acceptability of different responses by college faculty to a case description of a college student who engaged in plagiarism. The findings revealed that students found some methods of addressing this problem behavior by…

  1. Euthanasia Acceptance: An Attitudinal Inquiry.

    ERIC Educational Resources Information Center

    Klopfer, Fredrick J.; Price, William F.

    The study presented was conducted to examine potential relationships between attitudes regarding the dying process, including acceptance of euthanasia, and other attitudinal or demographic attributes. The data of the survey was comprised of responses given by 331 respondents to a door-to-door interview. Results are discussed in terms of preferred…

  2. PREDON Scientific Data Preservation 2014

    NASA Astrophysics Data System (ADS)

    Diaconu, C.; Kraml, S.; Surace, C.; Chateigner, D.; Libourel, T.; Laurent, A.; Lin, Y.; Schaming, M.; Benbernou, S.; Lebbah, M.; Boucon, D.; Cérin, C.; Azzag, H.; Mouron, P.; Nief, J.-Y.; Coutin, S.; Beckmann, V.

    Scientific data collected with modern sensors or dedicated detectors exceed very often the perimeter of the initial scientific design. These data are obtained more and more frequently with large material and human efforts. A large class of scientific experiments are in fact unique because of their large scale, with very small chances to be repeated and to superseded by new experiments in the same domain: for instance high energy physics and astrophysics experiments involve multi-annual developments and a simple duplication of efforts in order to reproduce old data is simply not affordable. Other scientific experiments are in fact unique by nature: earth science, medical sciences etc. since the collected data is "time-stamped" and thereby non-reproducible by new experiments or observations. In addition, scientific data collection increased dramatically in the recent years, participating to the so-called "data deluge" and inviting for common reflection in the context of "big data" investigations. The new knowledge obtained using these data should be preserved long term such that the access and the re-use are made possible and lead to an enhancement of the initial investment. Data observatories, based on open access policies and coupled with multi-disciplinary techniques for indexing and mining may lead to truly new paradigms in science. It is therefore of outmost importance to pursue a coherent and vigorous approach to preserve the scientific data at long term. The preservation remains nevertheless a challenge due to the complexity of the data structure, the fragility of the custom-made software environments as well as the lack of rigorous approaches in workflows and algorithms. To address this challenge, the PREDON project has been initiated in France in 2012 within the MASTODONS program: a Big Data scientific challenge, initiated and supported by the Interdisciplinary Mission of the National Centre for Scientific Research (CNRS). PREDON is a study group formed by

  3. A novel support vector machine with globality-locality preserving.

    PubMed

    Ma, Cheng-Long; Yuan, Yu-Bo

    2014-01-01

    Support vector machine (SVM) is regarded as a powerful method for pattern classification. However, the solution of the primal optimal model of SVM is susceptible for class distribution and may result in a nonrobust solution. In order to overcome this shortcoming, an improved model, support vector machine with globality-locality preserving (GLPSVM), is proposed. It introduces globality-locality preserving into the standard SVM, which can preserve the manifold structure of the data space. We complete rich experiments on the UCI machine learning data sets. The results validate the effectiveness of the proposed model, especially on the Wine and Iris databases; the recognition rate is above 97% and outperforms all the algorithms that were developed from SVM. PMID:25045750

  4. 46 CFR 160.055-5 - Construction-standard life preservers.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... the life preserver is fully cured, a nylon webbing body strap shall be attached as shown on Dwg. No... of Federal Standard 751, with nylon thread, and there shall be not less than 9 nor more than 11 stitches to the inch. Bar tacking with nylon thread is acceptable as noted on Dwg. No. 160-055-IA....

  5. 46 CFR 160.055-5 - Construction-standard life preservers.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... the life preserver is fully cured, a nylon webbing body strap shall be attached as shown on Dwg. No... of Federal Standard 751, with nylon thread, and there shall be not less than 9 nor more than 11 stitches to the inch. Bar tacking with nylon thread is acceptable as noted on Dwg. No. 160-055-IA....

  6. 46 CFR 160.055-5 - Construction-standard life preservers.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... the life preserver is fully cured, a nylon webbing body strap shall be attached as shown on Dwg. No... of Federal Standard 751, with nylon thread, and there shall be not less than 9 nor more than 11 stitches to the inch. Bar tacking with nylon thread is acceptable as noted on Dwg. No. 160-055-IA....

  7. 46 CFR 160.055-5 - Construction-standard life preservers.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... the life preserver is fully cured, a nylon webbing body strap shall be attached as shown on Dwg. No... of Federal Standard 751, with nylon thread, and there shall be not less than 9 nor more than 11 stitches to the inch. Bar tacking with nylon thread is acceptable as noted on Dwg. No. 160-055-IA....

  8. 46 CFR 160.055-5 - Construction-standard life preservers.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... the life preserver is fully cured, a nylon webbing body strap shall be attached as shown on Dwg. No... of Federal Standard 751, with nylon thread, and there shall be not less than 9 nor more than 11 stitches to the inch. Bar tacking with nylon thread is acceptable as noted on Dwg. No. 160-055-IA....

  9. Small bowel preservation for intestinal transplantation: a review.

    PubMed

    Roskott, Anne Margot C; Nieuwenhuijs, Vincent B; Dijkstra, Gerard; Koudstaal, Lyan G; Leuvenink, Henri G D; Ploeg, Rutger J

    2011-02-01

    Intestinal transplantation has become the therapy of choice for patients with intestinal failure and life-threatening complications from total parenteral nutrition. Results, however, remain inferior as compared with other transplant types with the quality of the organ graft as the most important factor of outcome after transplantation. The intestine is extremely sensitive to ischemia. Unfortunately, a relatively long ischemic preservation period is inevitable. The current standard in organ preservation [cold storage (CS) with University of Wisconsin solution] was developed for kidney/liver preservation and is suboptimal for the intestinal graft despite good results for other organs. This review aimed at appraising the results from the use of previously applied and recently developed preservation solutions and techniques to identify key areas for improvement. As the studies available do not reveal the most effective method for intestinal preservation, an optimal strategy will result from a synergistic effect of different vital elements identified from a review of published material from the literature. A key factor is the composition of the solution using a low-viscosity solution to facilitate washout of blood, including amino acids to improve viability, impermeants and colloids to prevent edema, and buffer for pH-homeostasis. Optimizing conditions include a vascular flush before CS and luminal preservation. The most effective composition of the luminal solution and a practical, clinically applicable optimal technique are yet to reach finality. Short-duration oxygenated arterial and/or luminal perfusion have to be considered. Thus, a tailor-made approach to luminal preservation solution and technique need further investigation in transplant models and the human setting to develop the ultimate technique meeting the physiologic demands of the intestinal graft during preservation. PMID:21083772

  10. Educational Technology Acceptance across Cultures: A Validation of the Unified Theory of Acceptance and Use of Technology in the Context of Turkish National Culture

    ERIC Educational Resources Information Center

    Gogus, Aytac; Nistor, Nicolae; Riley, Richard W.; Lerche, Thomas

    2012-01-01

    The Unified Theory of Acceptance and Use of Technology (UTAUT; Venkatesh et al., 2003, 2012) proposes a major model of educational technology acceptance (ETA) which has been yet validated only in few languages and cultures. Therefore, this study aims at extending the applicability of UTAUT to Turkish culture. Based on acceptance and cultural data…

  11. Celastrol Inhibits Lung Infiltration in Differential Syndrome Animal Models by Reducing TNF-α and ICAM-1 Levels while Preserving Differentiation in ATRA-Induced Acute Promyelocytic Leukemia Cells

    PubMed Central

    Xu, Li-min; Zheng, Yue-juan; Wang, Ying; Yang, Yang; Cao, Fan-fan; Peng, Bin; Xu, Xiong-fei; An, Hua-zhang; Zheng, Ao-xiang; Zhang, Deng-hai; Uzan, Georges; Yu, Yi-zhi

    2014-01-01

    All-trans retinoic acid (ATRA) is a revolutionary agent for acute promyelocytic leukemia (APL) treatment via differentiation induction. However, ATRA treatment also increases cytokine, chemokine, and adhesive molecule (mainly ICAM-1) expression, which can cause clinical complications, including a severe situation known as differentiation syndrome (DS) which can cause death. Therefore, it is of clinical significance to find a strategy to specifically blunt inflammatory effects while preserving differentiation. Here we report that the natural compound, celastrol, could effectively block lung infiltrations in DS animal models created by loading ATRA-induced APL cell line NB4. In ATRA-treated NB4 cells, celastrol could potently inhibit ICAM-1 elevation and partially reduce TNF-α and IL-1β secretion, though treatment showed no effects on IL-8 and MCP-1 levels. Celastrol’s effect on ICAM-1 in ATRA-treated NB4 was related to reducing MEK1/ERK1 activation. Strikingly and encouragingly, celastrol showed no obvious effects on ATRA-induced NB4 differentiation, as determined by morphology, enzymes, and surface markers. Our results show that celastrol is a promising and unique agent for managing the side effects of ATRA application on APL, and suggest that hyper-inflammatory ability is accompanied by, but not necessary for, APL differentiation. Thus we offered an encouraging novel strategy to further improve differentiation therapy. PMID:25116125

  12. What is meant by the term acceptance of technology and locating the acceptance of the CCS Technology?

    NASA Astrophysics Data System (ADS)

    Harz, Mario; Vesper, Anton

    2013-04-01

    abstract: The formal language of logic expresses concepts and statements exactly. The logic of relations can serve as an important ressource for the philosophical analysis of technology and the construction of philosophical propositions about acceptance of technology. The theory of logical relations is used to investigate the theoretical structure of how acceptance of technologies can be revealed. The term "ordered tuple" helps to define the basis of the concept of logical relations. The term "acceptance of technology" refers to neither a thing nor a property; but to a complex relationship. The research refers to the study of the properties of this complex relationship. It examines the properties of reflexivity, total reflexivity, symmetry, transitivity, irreflexivity and asymmetry. Using these properties and the rules for forming converses-relations and partial-relations the question is analyzed: What, in general, is meant by the term "acceptance of technology?" These properties have been observed empirically at a discussion forum for the key players in the Brandenburg discourse on the acceptance of CCS technology. The meeting was held on the 8th of May 2012 in St. Nicholas Church, Cottbus (GER). The pragma-dialectical theory of argumentation is used to locate the acceptance of the CCS technology. With the ideal model of critical discussion as the methodological starting point the term "acceptance" can be defined in terms of the four meta-theoretical principles of the theory. That boils down to the findings that acceptance is the externalization of a positive commitment towards a proposition, acceptance is expressed by the speech act "to accept" and acceptance occurs in the dialogical, interactional setting of a critical discussion with the aim of resolving a difference of opinion. In the study differences of opinion about (descriptive, normative, evaluative) standpoints about the CCS technology from everyday problem-solving discussions are investigated. The

  13. Psychiatry Goes Mod, Accepts Behavior Model

    ERIC Educational Resources Information Center

    Science News, 1973

    1973-01-01

    Discusses the report of a task force of the American Psychiatric Association signaling change in the attitude of traditional psychiatry towards behavioral therapy. The report recognizes the effectiveness of behavior modifications and recommends that the teaching of behavior therapy be expanded. (JR)

  14. Strategies of laparoscopic spleen-preserving splenic hilar lymph node dissection for advanced proximal gastric cancer.

    PubMed

    Chen, Qi-Yue; Huang, Chang-Ming; Zheng, Chao-Hui; Li, Ping; Xie, Jian-Wei; Wang, Jia-Bin; Lin, Jian-Xian; Lu, Jun; Cao, Long-Long; Lin, Mi; Tu, Ru-Hong; Hong, Zhi-Liang

    2016-06-27

    For advanced proximal gastric cancer (GC), splenic hilar (No. 10) lymph nodes (LN) are crucial links in lymphatic drainage. According to the 14(th) edition of the Japanese GC treatment guidelines, a D2 lymphadenectomy is the standard surgery for advanced GC, and No. 10 LN should be dissected for advanced proximal GC. In recent years, the preservation of organ function and the use of minimally invasive technology are being accepted by an increasing number of clinicians. Laparoscopic spleen-preserving splenic hilar LN dissection has become more accepted and is gradually being used in operations. However, because of the complexity of splenic hilar anatomy, mastering the strategies for laparoscopic spleen-preserving splenic hilar LN dissection is critical for successfully completing the operation. PMID:27358672

  15. Strategies of laparoscopic spleen-preserving splenic hilar lymph node dissection for advanced proximal gastric cancer

    PubMed Central

    Chen, Qi-Yue; Huang, Chang-Ming; Zheng, Chao-Hui; Li, Ping; Xie, Jian-Wei; Wang, Jia-Bin; Lin, Jian-Xian; Lu, Jun; Cao, Long-Long; Lin, Mi; Tu, Ru-Hong; Hong, Zhi-Liang

    2016-01-01

    For advanced proximal gastric cancer (GC), splenic hilar (No. 10) lymph nodes (LN) are crucial links in lymphatic drainage. According to the 14th edition of the Japanese GC treatment guidelines, a D2 lymphadenectomy is the standard surgery for advanced GC, and No. 10 LN should be dissected for advanced proximal GC. In recent years, the preservation of organ function and the use of minimally invasive technology are being accepted by an increasing number of clinicians. Laparoscopic spleen-preserving splenic hilar LN dissection has become more accepted and is gradually being used in operations. However, because of the complexity of splenic hilar anatomy, mastering the strategies for laparoscopic spleen-preserving splenic hilar LN dissection is critical for successfully completing the operation. PMID:27358672

  16. The Acceptance and Use of a Virtual Learning Environment in China

    ERIC Educational Resources Information Center

    van Raaij, Erik M.; Schepers, Jeroen J. L.

    2008-01-01

    The success of a virtual learning environment (VLE) depends to a considerable extent on student acceptance and use of such an e-learning system. After critically assessing models of technology adoption, including the Technology Acceptance Model (TAM), TAM2, and the Unified Theory of Acceptance and Usage of Technology (UTAUT), we build a conceptual…

  17. Planning for Preservation. SPEC Kit 66.

    ERIC Educational Resources Information Center

    Association of Research Libraries, Washington, DC. Office of Management Studies.

    In a March 1980 Systems and Procedures Exchange Center (SPEC) survey on preservation activities in Association of Research Libraries (ARL) member institutions, 40 libraries reported having conducted a formal preservation study or needs assessment, 28 had adopted planning or policy documents, and 58 reported operating an active preservation program…

  18. 32 CFR 174.18 - Historic preservation.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... the regulations implementing the National Historic Preservation Act (36 CFR 800.5(a)(2)(vii)). One way... 32 National Defense 1 2014-07-01 2014-07-01 false Historic preservation. 174.18 Section 174.18... Historic preservation. (a) The transfer, lease, or sale of National Register-eligible historic property...

  19. 32 CFR 174.18 - Historic preservation.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... the regulations implementing the National Historic Preservation Act (36 CFR 800.5(a)(2)(vii)). One way... 32 National Defense 1 2013-07-01 2013-07-01 false Historic preservation. 174.18 Section 174.18... Historic preservation. (a) The transfer, lease, or sale of National Register-eligible historic property...

  20. 32 CFR 174.18 - Historic preservation.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... the regulations implementing the National Historic Preservation Act (36 CFR 800.5(a)(2)(vii)). One way... 32 National Defense 1 2012-07-01 2012-07-01 false Historic preservation. 174.18 Section 174.18... Historic preservation. (a) The transfer, lease, or sale of National Register-eligible historic property...

  1. 32 CFR 174.18 - Historic preservation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... the regulations implementing the National Historic Preservation Act (36 CFR 800.5(a)(2)(vii)). One way... 32 National Defense 1 2010-07-01 2010-07-01 false Historic preservation. 174.18 Section 174.18... Historic preservation. (a) The transfer, lease, or sale of National Register-eligible historic property...

  2. 32 CFR 174.18 - Historic preservation.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... the regulations implementing the National Historic Preservation Act (36 CFR 800.5(a)(2)(vii)). One way... 32 National Defense 1 2011-07-01 2011-07-01 false Historic preservation. 174.18 Section 174.18... Historic preservation. (a) The transfer, lease, or sale of National Register-eligible historic property...

  3. Commission on Preservation and Access Newsletter, 1995.

    ERIC Educational Resources Information Center

    Commission on Preservation and Access Newsletter, 1995

    1995-01-01

    The Commission on Preservation and Access was established to foster and support collaboration among libraries and allied organizations in order to ensure the preservation of the published and documentary records in all formats and to provide enhanced access to scholarly information. The Commission's newsletter keeps preservation and access…

  4. Preserving Library Materials in the South Pacific.

    ERIC Educational Resources Information Center

    Kivia, Ivarature

    1994-01-01

    Discusses problems of preservation and conservation of library materials in the South Pacific, including environmental factors, insect and animal pests, and mishandling. Describes the situation in national, public, and academic libraries in the region; factors in planning library buildings to promote preservation; and preservation efforts at the…

  5. Preservation Impacts on Educational Facilities Planning.

    ERIC Educational Resources Information Center

    Shultz, James A.

    This paper examines the significance of facilities preservation for educational facilities planning and identifies various forms of facilities preservation applicable to educational facilities. It analyzes why educational facilities planners need to be aware of preservation considerations, reviews the relevant literature for preservation…

  6. Orthogonality preserving infinite dimensional quadratic stochastic operators

    SciTech Connect

    Akın, Hasan; Mukhamedov, Farrukh

    2015-09-18

    In the present paper, we consider a notion of orthogonal preserving nonlinear operators. We introduce π-Volterra quadratic operators finite and infinite dimensional settings. It is proved that any orthogonal preserving quadratic operator on finite dimensional simplex is π-Volterra quadratic operator. In infinite dimensional setting, we describe all π-Volterra operators in terms orthogonal preserving operators.

  7. The Preservation of Paper Collections in Archives.

    ERIC Educational Resources Information Center

    Adams, Cynthia Ann

    The preservation methods used for paper collections in archives were studied through a survey of archives in the metropolitan Atlanta (Georgia) area. The preservation policy or program was studied, and the implications for conservators and preservation officers were noted. Twelve of 15 archives responded (response rate of 80 percent). Basic…

  8. Heritage/Culture Preservation Model Bilingual Instruction

    ERIC Educational Resources Information Center

    Samayoa, Heidi

    2014-01-01

    Our first generation children face a loss of heritage in today's public schools. Unfortunately, the assets that one's bilingual ability brings into the classroom are difficult for educators to fully understand. Often this may happen because professionals in the field of education lack the knowledge about the need for children to maintain…

  9. An algorithm for generalizing topography to grids while preserving subscale morphologic characteristics—creating a glacier bed DEM for Jakobshavn trough as low-resolution input for dynamic ice-sheet models

    NASA Astrophysics Data System (ADS)

    Herzfeld, Ute C.; Wallin, Bruce F.; Leuschen, Carlton J.; Plummer, Joel

    2011-11-01

    The objective of this paper is to derive an algorithm for preserving important subscale morphologic characteristics at grids of lower-resolution, in particular for linear features such as canyons and ridge lines. The development of such an algorithm is necessitated by applications that require reduced spatial resolution, as is common in cartographic generalization, GIS applications, and geophysical modeling. Since any algorithm that results in weighted averages, including optimum interpolation and ordinary kriging, cannot reproduce correct depths, a new algorithm is designed based on principles of mathematical morphology. The algorithm described here is applied to derive a subglacial bed of the Greenland Ice Sheet that includes the trough of Jakobshavn Isbræ as a continuous canyon at correct depth in a low-resolution (5-km) digital elevation model (DEM). Data from recent airborne radar measurements of the elevation of the subglacial bed as part of the CReSIS project are utilized. The morphologic algorithm is designed with geophysical ice-sheet modeling in mind, in the following context. Currently occurring changes in the Earth's climate and the cryosphere cause changes in sea level, and the societal relevance of these natural processes motivates estimation of maximal sea-level rise in the medium-term future. The fast-moving outlet glaciers are more sensitive to climatic change than other parts of the Greenland ice sheet. Jakobshavn Isbrae, the fastest-moving ice stream in Greenland, follows a subglacial geologic trough. Since the existence of the trough causes the acceleration of the slow-moving inland ice in the Jakobshavn region and the formation of the ice stream, correct representation of the trough in a DEM is essential to model changes in the dynamics of the ice sheet and resultant sea-level predictions, even if current ice-sheet models can typically be run only at 5-km resolution. The DEM resultant from this study helps to bridge the conceptual gap between

  10. Preserving mobility in older adults.

    PubMed Central

    Buchner, D M

    1997-01-01

    Age-related loss of strength contributes to impaired mobility and increases the risk of falls. Recent research has focused on 2 approaches to preventing age-related loss of strength--promoting physical activity and exercise (especially strength training) and using trophic factors to enhance muscle performance. Epidemiologic evidence strongly supports a role of regular physical activity in successful aging by preserving muscle performance, promoting mobility, and reducing fall risk. Randomized controlled trials provide convincing evidence that strength and endurance training improve muscle performance in older adults. Evidence is rapidly accumulating from randomized trials that endurance, strength, and balance training promote mobility and reduce fall risk, though exercise effects differ according to the type of exercise, details of the exercise program, and the target group of older adults. Because lifetime regular physical activity is recommended for all older adults, a reasonable strategy (especially for weak adults) is an activity program that includes strength training. In contrast, insufficient evidence exists to recommend the long-term use of trophic factors to preserve muscular performance. An intervention that merits additional study is avoiding the use of psychoactive drugs because drugs like benzodiazepines appear to be risk factors for inactivity and may have unrecognized direct effects on muscular performance. Because chronic illness is a risk factor for inactivity and disuse muscle atrophy, randomized trials comparing strength training with other interventions would be useful in understanding whether strength training has advantages in preserving muscle performance and improving health-related quality of life in a variety of chronic illnesses such as depressive illness. PMID:9348757

  11. Polarization preservation in the AGS

    SciTech Connect

    Ratner, L.G.

    1983-01-01

    The successful operation of a high energy polarized beam at the Argonne Zero Gradient Synchrotron (ZGS) with the concommitant development of depolarizing resonance correction techniques has led to the present project of commissioning such a beam at the Brookhaven Alternating Gradient Synchrotron (AGS). A description of the project was presented at the 1981 National Accelerator Conference. I would like to now present a more detailed description of how we plan to preserve the polarization during acceleration, and to present our game plan for tuning through some 50 resonances and reaching our goal of a 26 GeV polarized proton beam with greater than 60% polarization.

  12. Preservation of sweet sorghum biomass

    SciTech Connect

    Jasberg, B.K.; Montgomery, R.R.; Anderson, R.A.

    1983-01-01

    Sweet sorghum stalks (42% sugar, dry basis (d.b.)) and bagasse (10% sugar, d.b.) from a cane mill were stored to preserve sugar. Bagasse and stalks were stored outdoors in sealed containers (anaerobic conditions). Treatments included using carbon dioxide or sulfur dioxide atmospheres or surface spraying with propionic acid or aqueous ammonia. Stalks were also stored outdoors under aerobic conditions. Treatments included drying the stalks or spraying with propionic acid. After 200 days, propionic acid (anaerobic) and SO/sub 2/-treated stalks had 34% and 19% of the original sugar remaining, respectively. No other samples had more than 3% of the original sugar remaining. 28 references, 6 tables.

  13. Acceptability of reactors in space

    SciTech Connect

    Buden, D.

    1981-04-01

    Reactors are the key to our future expansion into space. However, there has been some confusion in the public as to whether they are a safe and acceptable technology for use in space. The answer to these questions is explored. The US position is that when reactors are the preferred technical choice, that they can be used safely. In fact, it dies not appear that reactors add measurably to the risk associated with the Space Transportation System.

  14. Acceptability of reactors in space

    SciTech Connect

    Buden, D.

    1981-01-01

    Reactors are the key to our future expansion into space. However, there has been some confusion in the public as to whether they are a safe and acceptable technology for use in space. The answer to these questions is explored. The US position is that when reactors are the preferred technical choice, that they can be used safely. In fact, it does not appear that reactors add measurably to the risk associated with the Space Transportation System.

  15. Reactor tank UT acceptance criteria

    SciTech Connect

    Daugherty, W.L.

    1990-01-30

    The SRS reactor tanks are constructed of type 304 stainless steel, with 0.5 inch thick walls. An ultrasonic (UT) in-service inspection program has been developed for examination of these tanks, in accordance with the ISI Plan for the Savannah River Production Reactors Process Water System (DPSTM-88-100-1). Prior to initiation of these inspections, criteria for the disposition of any indications that might be found are required. A working group has been formed to review available information on the SRS reactor tanks and develop acceptance criteria. This working group includes nationally recognized experts in the nuclear industry. The working group has met three times and produced three documents describing the proposed acceptance criteria, the technical basis for the criteria and a proposed initial sampling plan. This report transmits these three documents, which were prepared in accordance with the technical task plan and quality assurance plan for this task, task 88-001-A- 1. In addition, this report summarizes the acceptance criteria and proposed sampling plan, and provides further interpretation of the intent of these three documents where necessary.

  16. 12 CFR 7.1007 - Acceptances.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Acceptances. 7.1007 Section 7.1007 Banks and... § 7.1007 Acceptances. A national bank is not limited in the character of acceptances it may make in financing credit transactions. Bankers' acceptances may be used for such purpose, since the making...

  17. 12 CFR 7.1007 - Acceptances.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 1 2011-01-01 2011-01-01 false Acceptances. 7.1007 Section 7.1007 Banks and... § 7.1007 Acceptances. A national bank is not limited in the character of acceptances it may make in financing credit transactions. Bankers' acceptances may be used for such purpose, since the making...

  18. 21 CFR 820.86 - Acceptance status.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Acceptance status. 820.86 Section 820.86 Food and... QUALITY SYSTEM REGULATION Acceptance Activities § 820.86 Acceptance status. Each manufacturer shall identify by suitable means the acceptance status of product, to indicate the conformance or...

  19. 12 CFR 615.5550 - Bankers' acceptances.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 6 2011-01-01 2011-01-01 false Bankers' acceptances. 615.5550 Section 615.5550... POLICIES AND OPERATIONS, AND FUNDING OPERATIONS Bankers' Acceptances § 615.5550 Bankers' acceptances. Banks for cooperatives may rediscount with other purchasers the acceptances they have created. The bank...

  20. 48 CFR 245.606-3 - Acceptance.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Acceptance. 245.606-3... Contractor Inventory 245.606-3 Acceptance. (a) If the schedules are acceptable, the plant clearance officer shall, within 15 days, complete and send the contractor a DD Form 1637, Notice of Acceptance...

  1. 48 CFR 12.402 - Acceptance.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Acceptance. 12.402 Section... Acceptance. (a) The acceptance paragraph in 52.212-4 is based upon the assumption that the Government will rely on the contractor's assurances that the commercial item tendered for acceptance conforms to...

  2. 21 CFR 820.86 - Acceptance status.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Acceptance status. 820.86 Section 820.86 Food and... QUALITY SYSTEM REGULATION Acceptance Activities § 820.86 Acceptance status. Each manufacturer shall identify by suitable means the acceptance status of product, to indicate the conformance or...

  3. 12 CFR 615.5550 - Bankers' acceptances.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Bankers' acceptances. 615.5550 Section 615.5550... POLICIES AND OPERATIONS, AND FUNDING OPERATIONS Bankers' Acceptances § 615.5550 Bankers' acceptances. Banks for cooperatives may rediscount with other purchasers the acceptances they have created. The bank...

  4. 48 CFR 12.402 - Acceptance.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Acceptance. 12.402 Section... Acceptance. (a) The acceptance paragraph in 52.212-4 is based upon the assumption that the Government will rely on the contractor's assurances that the commercial item tendered for acceptance conforms to...

  5. Response of the μ-opioid system to social rejection and acceptance.

    PubMed

    Hsu, D T; Sanford, B J; Meyers, K K; Love, T M; Hazlett, K E; Wang, H; Ni, L; Walker, S J; Mickey, B J; Korycinski, S T; Koeppe, R A; Crocker, J K; Langenecker, S A; Zubieta, J-K

    2013-11-01

    The endogenous opioid system, which alleviates physical pain, is also known to regulate social distress and reward in animal models. To test this hypothesis in humans (n=18), we used an μ-opioid receptor (MOR) radiotracer to measure changes in MOR availability in vivo with positron emission tomography during social rejection (not being liked by others) and acceptance (being liked by others). Social rejection significantly activated the MOR system (i.e., reduced receptor availability relative to baseline) in the ventral striatum, amygdala, midline thalamus and periaqueductal gray (PAG). This pattern of activation is consistent with the hypothesis that the endogenous opioids have a role in reducing the experience of social pain. Greater trait resiliency was positively correlated with MOR activation during rejection in the amygdala, PAG and subgenual anterior cingulate cortex (sgACC), suggesting that MOR activation in these areas is protective or adaptive. In addition, MOR activation in the pregenual ACC was correlated with reduced negative affect during rejection. In contrast, social acceptance resulted in MOR activation in the amygdala and anterior insula, and MOR deactivation in the midline thalamus and sgACC. In the left ventral striatum, MOR activation during acceptance predicted a greater desire for social interaction, suggesting a role for the MOR system in social reward. The ventral striatum, amygdala, midline thalamus, PAG, anterior insula and ACC are rich in MORs and comprise a pathway by which social cues may influence mood and motivation. MOR regulation of this pathway may preserve and promote emotional well being in the social environment. PMID:23958960

  6. Breathing air trailer acceptance test procedure

    SciTech Connect

    Kostelnik, A.J.

    1994-09-14

    This Acceptance Test Procedure (ATP) will document compliance with the requirements of WHC-S-0251 Rev. 0 and ECNs 613530 and 606113. The equipment being tested is a Breathing Air Supply Trailer purchased as a Design and Fabrication procurement activity for use in the core sampling program. The ATP was written by the Seller and will be performed by the Seller with representatives of the Westinghouse Hanford Company witnessing the test at the Seller`s location. This test procedure is to verify that the American Bristol Industries, Inc., Model 5014-0001 low pressure Mobile Breathing Air Trailer, meets or exceeds the requirements of the Westinghouse Hanford specification.

  7. Psychological Counseling of Female Fertility Preservation Patients.

    PubMed

    Lawson, Angela K; Klock, Susan C; Pavone, Mary Ellen; Hirshfeld-Cytron, Jennifer; Smith, Kristin N; Kazer, Ralph R

    2015-01-01

    Young cancer patients are increasingly interested in preserving their fertility prior to undergoing gonadotoxic therapies. Although the medical safety and treatment protocols for fertility preservation have been well documented, limited research has addressed the emotional issues that arise in fertility preservation patients. We briefly review the literature on the psychosocial issues in adult female fertility preservation treatment and describe our experiences within this patient population. Our findings suggest that several important issues to be addressed during the psychological counseling of adult female fertility preservation patients include: (1) preexisting psychological distress in patients undergoing treatment, (2) choice of fertility preservation strategy in the face of an uncertain relationship future, (3) decision making regarding use of third-party reproduction (e.g., sperm/egg donation, gestational surrogacy), (4) treatment expectations regarding pregnancy and miscarriage, (5) ethical issues related to treatment including the creation, cryopreservation, and disposition of embryos/oocytes, and (6) decision regret from patients who declined fertility preservation. PMID:25996581

  8. Fertility preservation in gynecological cancers.

    PubMed

    Chhabra, Shakuntala; Kutchi, Imran

    2013-03-21

    For cancers of reproductive system in women, fertility preservation is complex. Fertility is also affected by therapies, however prevention is possible. Radiotherapy affects gonads, uterus, and subsequent pregnancy outcomes in all ages. However, degree and damage depend on dose, irradiation field, and age at the time of exposure. Ovarian transposition is considered if ovarian involvement is unlikely. Gonadotoxic effects of chemotherapy are related to agent's type, cumulative doses, age, and ovarian reserve. Some agents are highly toxic. Rendering follicular development quiescent by suppression of gonadotropins does reduce the ovarian damage. Simple or radical trachelectomy can be used in early cervical cancer. Fertility saving surgery is possible only in early stage low grade epithelial cancers of the ovary, however, in germ cell tumors even in advanced stages it may be possible to preserve fertility. There are no standard recommendations for endometrial cancer. Embryo, oocyte, and ovarian tissue cryopreservation are possible. The human embryo is very resistant to damage. In view of these possibilities, it is advocated that attention to long term health and quality of life in gonadotoxic therapy must be incorporated into plans as early as possible. PMID:24453519

  9. Low-Rank Preserving Projections.

    PubMed

    Lu, Yuwu; Lai, Zhihui; Xu, Yong; Li, Xuelong; Zhang, David; Yuan, Chun

    2016-08-01

    As one of the most popular dimensionality reduction techniques, locality preserving projections (LPP) has been widely used in computer vision and pattern recognition. However, in practical applications, data is always corrupted by noises. For the corrupted data, samples from the same class may not be distributed in the nearest area, thus LPP may lose its effectiveness. In this paper, it is assumed that data is grossly corrupted and the noise matrix is sparse. Based on these assumptions, we propose a novel dimensionality reduction method, named low-rank preserving projections (LRPP) for image classification. LRPP learns a low-rank weight matrix by projecting the data on a low-dimensional subspace. We use the L21 norm as a sparse constraint on the noise matrix and the nuclear norm as a low-rank constraint on the weight matrix. LRPP keeps the global structure of the data during the dimensionality reduction procedure and the learned low rank weight matrix can reduce the disturbance of noises in the data. LRPP can learn a robust subspace from the corrupted data. To verify the performance of LRPP in image dimensionality reduction and classification, we compare LRPP with the state-of-the-art dimensionality reduction methods. The experimental results show the effectiveness and the feasibility of the proposed method with encouraging results. PMID:26277014

  10. Ridge Preservation for Implant Therapy: a Review of the Literature

    PubMed Central

    Tomlin, Elizabeth M; Nelson, Shelby J; Rossmann, Jeffrey A

    2014-01-01

    Healing of the extraction socket after tooth removal involves retention of the blood clot followed by a sequence of events that lead to changes in the alveolar process in a three dimensional fashion. This normal healing event results in a minimal loss of vertical height (around 1 mm), but a substantial loss of width in the buccal-lingual plane (4-6 mm). During the first three months following extraction that loss has been shown to be significant and may result in both a hard tissue and soft tissue deformity affecting the ability to restore the site with acceptable esthetics. Procedures that reduce the resorptive process have been shown to be predictable and potentially capable of eliminating secondary surgery for site preparation when implant therapy is planned. The key element is prior planning by the dental therapist to act at the time of extraction to prevent the collapse of the ridge due to the loss of the alveolus. Several techniques have been employed as ridge preservation procedures involving the use of bone grafts, barrier membranes and biologics to provide a better restorative outcome. This review will explore the evidence behind each technique and their efficacy in accomplishing site preparation. The literature does not identify a single technique as superior to others; however, all accepted therapeutic procedures for ridge preservation have been shown to be more effective than blood clot alone in randomized controlled studies. PMID:24893595

  11. Functional organ preservation in laryngeal and hypopharyngeal cancer

    PubMed Central

    Ambrosch, Petra; Fazel, Asita

    2012-01-01

    The principles of open versus laser microsurgical approaches for partial resections of the larynx are described, oncologic as well as functional results discussed and corresponding outcomes following primary radiotherapy are opposed. Over the last decade, the endoscopic partial resection of the larynx has developed to an accepted approach in the treatment of early glottic and supraglottic carcinomas thus leading to a remarkable decline in the use of open surgery. Comparing the various surgical approaches of laryngeal partial resections, the oncological outcome of the patients, as far as survival and organ preservation are concerned, are comparable, whereas functional results of the endoscopic procedures are superior with less morbidity. The surgical procedures put together, are all superior to radiotherapy concerning organ preservation. Transoral laser microsurgery has been used successfully for vocal cord carcinomas with impaired mobility or fixation of the vocal cord, supraglottic carcinomas with infiltration of the pre- and/or paraglottic space as well as for selected hypopharyngeal carcinomas. It has been well documented that laser microsurgery achieves good oncological as well as functional results with reasonable morbidity. However, patients with those tumours have been successfully treated by open partial resections of the larynx at medical centres with appropriate expertise. The initially enthusiastic assessment of study results concerning the efficacy of various protocols of chemoradiation with the intent of organ preservation for laryngeal and hypopharyngeal carcinomas are judged more cautious, today, due to recent reports of rather high rates of late toxicity complications. PMID:22558052

  12. Exploring the Intrinsic Motivation of Hedonic Information Systems Acceptance: Integrating Hedonic Theory and Flow with TAM

    NASA Astrophysics Data System (ADS)

    Wang, Zhihuan

    Research on Information Systems (IS) acceptance is substantially focused on extrinsic motivation in workplaces, little is known about the underlying intrinsic motivations of Hedonic IS (HIS) acceptance. This paper proposes a hybrid HIS acceptance model which takes the unique characteristics of HIS and multiple identities of a HIS user into consideration by interacting Hedonic theory, Flow theory with Technology Acceptance Model (TAM). The model was empirically tested by a field survey. The result indicates that emotional responses, imaginal responses, and flow experience are three main contributions of HIS acceptance.

  13. Image Stitching with Perspective-Preserving Warping

    NASA Astrophysics Data System (ADS)

    Xiang, Tianzhu; Xia, Gui-Song; Zhang, Liangpei

    2016-06-01

    Image stitching algorithms often adopt the global transform, such as homography, and work well for planar scenes or parallax free camera motions. However, these conditions are easily violated in practice. With casual camera motions, variable taken views, large depth change, or complex structures, it is a challenging task for stitching these images. The global transform model often provides dreadful stitching results, such as misalignments or projective distortions, especially perspective distortion. To this end, we suggest a perspective-preserving warping for image stitching, which spatially combines local projective transforms and similarity transform. By weighted combination scheme, our approach gradually extrapolates the local projective transforms of the overlapping regions into the non-overlapping regions, and thus the final warping can smoothly change from projective to similarity. The proposed method can provide satisfactory alignment accuracy as well as reduce the projective distortions and maintain the multi-perspective view. Experimental analysis on a variety of challenging images confirms the efficiency of the approach.

  14. Marketing Social Change: The Case of Family Preservation.

    ERIC Educational Resources Information Center

    Adams, Paul

    1994-01-01

    Examines the promotion of the Homebuilders type of family preservation services. Suggests that successful marketing and dissemination of a single program design, in this policy environment, may displace other, equally effective programs and models. Notes that such success in marketing may also have adverse effects on research, education, continued…

  15. Challenges of Digital Preservation for Cultural Heritage Institutions

    ERIC Educational Resources Information Center

    Evens, Tom; Hauttekeete, Laurence

    2011-01-01

    This article elaborates four major issues hampering the sustainability of digital preservation within cultural heritage institutions: digitization, metadata indexes, intellectual property rights management and business models. Using a case-study approach, the digitization of audiovisual collections within the performing arts institutions in…

  16. Saliva Preservative for Diagnostic Purposes

    NASA Technical Reports Server (NTRS)

    Pierson, Duane L.; Mehta, Satish K.

    2012-01-01

    Saliva is an important body fluid for diagnostic purposes. Glycoproteins, glucose, steroids, DNA, and other molecules of diagnostic value are found in saliva. It is easier to collect as compared to blood or urine. Unfortunately, saliva also contains large numbers of bacteria that can release enzymes, which can degrade proteins and nucleic acids. These degradative enzymes destroy or reduce saliva s diagnostic value. This innovation describes the formulation of a chemical preservative that prevents microbial growth and inactivates the degradative enzymes. This extends the time that saliva can be stored or transported without losing its diagnostic value. Multiple samples of saliva can be collected if needed without causing discomfort to the subject and it does not require any special facilities to handle after it is collected.

  17. Boundary Preserving Dense Local Regions.

    PubMed

    Kim, Jaechul; Grauman, Kristen

    2015-05-01

    We propose a dense local region detector to extract features suitable for image matching and object recognition tasks. Whereas traditional local interest operators rely on repeatable structures that often cross object boundaries (e.g., corners, scale-space blobs), our sampling strategy is driven by segmentation, and thus preserves object boundaries and shape. At the same time, whereas existing region-based representations are sensitive to segmentation parameters and object deformations, our novel approach to robustly sample dense sites and determine their connectivity offers better repeatability. In extensive experiments, we find that the proposed region detector provides significantly better repeatability and localization accuracy for object matching compared to an array of existing feature detectors. In addition, we show our regions lead to excellent results on two benchmark tasks that require good feature matching: weakly supervised foreground discovery and nearest neighbor-based object recognition. PMID:26353319

  18. Virtual Environments for Data Preservation

    NASA Astrophysics Data System (ADS)

    Beckmann, Volker

    Data preservation in a wider sense includes also the ability to analyse data of past experiments. Because operation systems, such as Linux and Windows, are evolving rapidly, software packages can be outdated and not usable anymore already a few years after they have been written. Creating an image of the operation system is a way to be able to launch the analysis software on a computing infrastructure independent on the local operation system used. At the same time, virtualization also allows to launch the same software in collaborations across several institutes with very different computing infrastructure. At the François Arago Centre of the APC in Paris we provide user support for virtualization and computing environment access to the scientific community

  19. Abdominoplasty With Scarpa Fascia Preservation.

    PubMed

    Costa-Ferreira, António; Marco, Rebelo; Vásconez, Luis; Amarante, José

    2016-06-01

    The plane of dissection used during a full abdominoplasty has been implicated on the seroma rate. Avoiding the classic plane of dissection on top of the rectus fascia and using a more superficial plane of dissection has been suggested as a strategy to improve recovery and lower the complication rate. The authors have been applying this principle in their practice for more than a decade, and they performed 2 prospective comparative studies to evaluate the clinical effects of using a more superficial plane of dissection (with Scarpa fascia preservation) during a full abdominoplasty.The technique is presented and explained along with the results of both comparative studies.The results of both studies are discussed particularly the effects on drain volume (total and daily), the duration of drain usage and the avoidance of "long drainers." These are very relevant advantages of the technique that have not been discussed in the literature. The results and surgical strategies used by other authors which apply a more superficial plane of dissection are presented.Controversy still exits on the manipulation of the deep fat compartment by liposuction or direct fat excision. No manipulation is another option which should be considered but it has been questioned due to the risk of aesthetic compromise. A morphometric study performed on the surgical specimens of 41 female patients submitted to a full abdominoplasty validates that option.Based on this evidence, the authors recommend that surgeons consider performing abdominoplasties using a more superficial plane of dissection in the infraumbilical area with total preservation of Scarpa fascia and the deep fat compartment. The classic plane of dissection, on top of the deep fascia, should be avoided in the lower abdomen. PMID:27187249

  20. Female fertility preservation: a clinical perspective.

    PubMed

    Pavone, Mary E; Confino, Rafael; Steinberg, Marissa

    2016-08-01

    For patients with cancer, preserving the ability to start a family at a time of their choosing is especially important and may influence decisions pertaining to cancer treatment. For other women who have delayed childbearing for personal or professional reasons, fertility preservation offers the possibility of having a biological child regardless of age. Though these women may be interested in or benefit from fertility preservation, fertility preservation services remain underutilized. While embryo and oocyte cryopreservation remain the standard strategies for female fertility preservation recommended by the American Society of Reproductive Medicine, the American Society of Clinical Oncology and the European Society of Medical Oncology, other strategies (e.g. pharmacological protection of the ovaries and ovarian tissue cryopreservation) are the subject of increasing research. This review will present new data that have become available over the past few years pertaining to all available methods of fertility preservation. PMID:26847846