Sample records for process transition models

  1. Performance of Transit Model Fitting in Processing Four Years of Kepler Science Data

    NASA Astrophysics Data System (ADS)

    Li, Jie; Burke, Christopher J.; Jenkins, Jon Michael; Quintana, Elisa V.; Rowe, Jason; Seader, Shawn; Tenenbaum, Peter; Twicken, Joseph D.

    2014-06-01

    We present transit model fitting performance of the Kepler Science Operations Center (SOC) Pipeline in processing four years of science data, which were collected by the Kepler spacecraft from May 13, 2009 to May 12, 2013. Threshold Crossing Events (TCEs), which represent transiting planet detections, are generated by the Transiting Planet Search (TPS) component of the pipeline and subsequently processed in the Data Validation (DV) component. The transit model is used in DV to fit TCEs and derive parameters that are used in various diagnostic tests to validate planetary candidates. The standard transit model includes five fit parameters: transit epoch time (i.e. central time of first transit), orbital period, impact parameter, ratio of planet radius to star radius and ratio of semi-major axis to star radius. In the latest Kepler SOC pipeline codebase, the light curve of the target for which a TCE is generated is initially fitted by a trapezoidal model with four parameters: transit epoch time, depth, duration and ingress time. The trapezoidal model fit, implemented with repeated Levenberg-Marquardt minimization, provides a quick and high fidelity assessment of the transit signal. The fit parameters of the trapezoidal model with the minimum chi-square metric are converted to set initial values of the fit parameters of the standard transit model. Additional parameters, such as the equilibrium temperature and effective stellar flux of the planet candidate, are derived from the fit parameters of the standard transit model to characterize pipeline candidates for the search of Earth-size planets in the Habitable Zone. The uncertainties of all derived parameters are updated in the latest codebase to take into account for the propagated errors of the fit parameters as well as the uncertainties in stellar parameters. The results of the transit model fitting of the TCEs identified by the Kepler SOC Pipeline, including fitted and derived parameters, fit goodness metrics and

  2. Modeling the transition region

    NASA Technical Reports Server (NTRS)

    Singer, Bart A.

    1993-01-01

    The current status of transition-region models is reviewed in this report. To understand modeling problems, various flow features that influence the transition process are discussed first. Then an overview of the different approaches to transition-region modeling is given. This is followed by a detailed discussion of turbulence models and the specific modifications that are needed to predict flows undergoing laminar-turbulent transition. Methods for determining the usefulness of the models are presented, and an outlook for the future of transition-region modeling is suggested.

  3. Phase transition in conservative diffusive contact processes

    NASA Astrophysics Data System (ADS)

    Fiore, Carlos E.; de Oliveira, Mário J.

    2004-10-01

    We determine the phase diagrams of conservative diffusive contact processes by means of numerical simulations. These models are versions of the ordinary diffusive single-creation, pair-creation, and triplet-creation contact processes in which the particle number is conserved. The transition between the frozen and active states was determined by studying the system in the subcritical regime, and the nature of the transition, whether continuous or first order, was determined by looking at the fractal dimension of the critical cluster. For the single-creation model the transition remains continuous for any diffusion rate. For pair- and triplet-creation models, however, the transition becomes first order for high enough diffusion rate. Our results indicate that in the limit of infinite diffusion rate the jump in density equals 2/3 for the pair-creation model and 5/6 for the triplet-creation model.

  4. Design for success: Identifying a process for transitioning to an intensive online course delivery model in health professions education.

    PubMed

    McDonald, Paige L; Harwood, Kenneth J; Butler, Joan T; Schlumpf, Karen S; Eschmann, Carson W; Drago, Daniela

    2018-12-01

    Intensive courses (ICs), or accelerated courses, are gaining popularity in medical and health professions education, particularly as programs adopt e-learning models to negotiate challenges of flexibility, space, cost, and time. In 2014, the Department of Clinical Research and Leadership (CRL) at the George Washington University School of Medicine and Health Sciences began the process of transitioning two online 15-week graduate programs to an IC model. Within a year, a third program also transitioned to this model. A literature review yielded little guidance on the process of transitioning from 15-week, traditional models of delivery to IC models, particularly in online learning environments. Correspondingly, this paper describes the process by which CRL transitioned three online graduate programs to an IC model and details best practices for course design and facilitation resulting from our iterative redesign process. Finally, we present lessons-learned for the benefit of other medical and health professions' programs contemplating similar transitions. CRL: Department of Clinical Research and Leadership; HSCI: Health Sciences; IC: Intensive course; PD: Program director; QM: Quality Matters.

  5. Design for success: Identifying a process for transitioning to an intensive online course delivery model in health professions education

    PubMed Central

    McDonald, Paige L.; Harwood, Kenneth J.; Butler, Joan T.; Schlumpf, Karen S.; Eschmann, Carson W.; Drago, Daniela

    2018-01-01

    ABSTRACT Intensive courses (ICs), or accelerated courses, are gaining popularity in medical and health professions education, particularly as programs adopt e-learning models to negotiate challenges of flexibility, space, cost, and time. In 2014, the Department of Clinical Research and Leadership (CRL) at the George Washington University School of Medicine and Health Sciences began the process of transitioning two online 15-week graduate programs to an IC model. Within a year, a third program also transitioned to this model. A literature review yielded little guidance on the process of transitioning from 15-week, traditional models of delivery to IC models, particularly in online learning environments. Correspondingly, this paper describes the process by which CRL transitioned three online graduate programs to an IC model and details best practices for course design and facilitation resulting from our iterative redesign process. Finally, we present lessons-learned for the benefit of other medical and health professionsʼ programs contemplating similar transitions. Abbreviations: CRL: Department of Clinical Research and Leadership; HSCI: Health Sciences; IC: Intensive course; PD: Program director; QM: Quality Matters PMID:29277143

  6. Novel mathematic models for quantitative transitivity of quality-markers in extraction process of the Buyanghuanwu decoction.

    PubMed

    Zhang, Yu-Tian; Xiao, Mei-Feng; Deng, Kai-Wen; Yang, Yan-Tao; Zhou, Yi-Qun; Zhou, Jin; He, Fu-Yuan; Liu, Wen-Long

    2018-06-01

    Nowadays, to research and formulate an efficiency extraction system for Chinese herbal medicine, scientists have always been facing a great challenge for quality management, so that the transitivity of Q-markers in quantitative analysis of TCM was proposed by Prof. Liu recently. In order to improve the quality of extraction from raw medicinal materials for clinical preparations, a series of integrated mathematic models for transitivity of Q-markers in quantitative analysis of TCM were established. Buyanghuanwu decoction (BYHWD) was a commonly TCMs prescription, which was used to prevent and treat the ischemic heart and brain diseases. In this paper, we selected BYHWD as an extraction experimental subject to study the quantitative transitivity of TCM. Based on theory of Fick's Rule and Noyes-Whitney equation, novel kinetic models were established for extraction of active components. Meanwhile, fitting out kinetic equations of extracted models and then calculating the inherent parameters in material piece and Q-marker quantitative transfer coefficients, which were considered as indexes to evaluate transitivity of Q-markers in quantitative analysis of the extraction process of BYHWD. HPLC was applied to screen and analyze the potential Q-markers in the extraction process. Fick's Rule and Noyes-Whitney equation were adopted for mathematically modeling extraction process. Kinetic parameters were fitted and calculated by the Statistical Program for Social Sciences 20.0 software. The transferable efficiency was described and evaluated by potential Q-markers transfer trajectory via transitivity availability AUC, extraction ratio P, and decomposition ratio D respectively. The Q-marker was identified with AUC, P, D. Astragaloside IV, laetrile, paeoniflorin, and ferulic acid were studied as potential Q-markers from BYHWD. The relative technologic parameters were presented by mathematic models, which could adequately illustrate the inherent properties of raw materials

  7. Transition Models for Engineering Calculations

    NASA Technical Reports Server (NTRS)

    Fraser, C. J.

    2007-01-01

    While future theoretical and conceptual developments may promote a better understanding of the physical processes involved in the latter stages of boundary layer transition, the designers of rotodynamic machinery and other fluid dynamic devices need effective transition models now. This presentation will therefore center around the development of of some transition models which have been developed as design aids to improve the prediction codes used in the performance evaluation of gas turbine blading. All models are based on Narasimba's concentrated breakdown and spot growth.

  8. Exploring business process modelling paradigms and design-time to run-time transitions

    NASA Astrophysics Data System (ADS)

    Caron, Filip; Vanthienen, Jan

    2016-09-01

    The business process management literature describes a multitude of approaches (e.g. imperative, declarative or event-driven) that each result in a different mix of process flexibility, compliance, effectiveness and efficiency. Although the use of a single approach over the process lifecycle is often assumed, transitions between approaches at different phases in the process lifecycle may also be considered. This article explores several business process strategies by analysing the approaches at different phases in the process lifecycle as well as the various transitions.

  9. A Correlation-Based Transition Model using Local Variables. Part 1; Model Formation

    NASA Technical Reports Server (NTRS)

    Menter, F. R.; Langtry, R. B.; Likki, S. R.; Suzen, Y. B.; Huang, P. G.; Volker, S.

    2006-01-01

    A new correlation-based transition model has been developed, which is based strictly on local variables. As a result, the transition model is compatible with modern computational fluid dynamics (CFD) approaches, such as unstructured grids and massive parallel execution. The model is based on two transport equations, one for intermittency and one for the transition onset criteria in terms of momentum thickness Reynolds number. The proposed transport equations do not attempt to model the physics of the transition process (unlike, e.g., turbulence models) but from a framework for the implementation of correlation-based models into general-purpose CFD methods.

  10. Hillslope to fluvial process domain transitions in headwater catchments

    NASA Astrophysics Data System (ADS)

    Williams, Karen Mary

    The landscape is partitioned into hillslopes and unchanneled valleys (hollows), and colluvial (hillslope controlled) and alluvial (self-formed) channels. The key issue for any study of headwater catchments is the rational distinction between these elements. Accurate identification of process domain transitions from hillslopes to hollows, hollows to colluvial channels and colluvial to alluvial channels, are not obvious either in the field or from topographic data derived from remotely sensed data such as laser derived (LIDAR) digital elevation models. The research in this dissertation investigates the spatial arrangement of these landforms and how hillslope and fluvial process domains interact in two pairs of headwater catchments in southwest and central Montana, using LIDAR data. This dissertation uses digital terrain analysis of LIDAR-derived topography and field studies to investigate methods of detection, modeling, and prediction of process transitions from the hillslope to fluvial domains and within the fluvial domain, from colluvial to alluvial channel reaches. Inflections in the scaling relationships between landscape parameters such as flowpath length, unit stream power (a metric of the energy expended by the channel in doing work), and drainage area were used to detect transitions in flow regimes characteristic of hillslope, unchanneled valleys, and channeled landforms. Using the scale-invariant properties of fluvial systems as a threshold condition, magnitude-frequency distributions of curvature and the derivative of aspect were also used to detect hillslope, fluvial, and transitional process domains. Finally, within the classification of channeled landforms, the transition from colluvial to alluvial channels was detected using the presence/absence of repeating patterns in the power spectra of fluvial energy and channel form parameters. LIDAR-derived scaling relations and magnitude-frequency distributions successfully detected and predicted locations of

  11. Limited ability driven phase transitions in the coevolution process in Axelrod's model

    NASA Astrophysics Data System (ADS)

    Wang, Bing; Han, Yuexing; Chen, Luonan; Aihara, Kazuyuki

    2009-04-01

    We study the coevolution process in Axelrod's model by taking into account of agents' abilities to access information, which is described by a parameter α to control the geographical range of communication. We observe two kinds of phase transitions in both cultural domains and network fragments, which depend on the parameter α. By simulation, we find that not all rewiring processes pervade the dissemination of culture, that is, a very limited ability to access information constrains the cultural dissemination, while an exceptional ability to access information aids the dissemination of culture. Furthermore, by analyzing the network characteristics at the frozen states, we find that there exists a stage at which the network develops to be a small-world network with community structures.

  12. Convergence of Transition Probability Matrix in CLVMarkov Models

    NASA Astrophysics Data System (ADS)

    Permana, D.; Pasaribu, U. S.; Indratno, S. W.; Suprayogi, S.

    2018-04-01

    A transition probability matrix is an arrangement of transition probability from one states to another in a Markov chain model (MCM). One of interesting study on the MCM is its behavior for a long time in the future. The behavior is derived from one property of transition probabilty matrix for n steps. This term is called the convergence of the n-step transition matrix for n move to infinity. Mathematically, the convergence of the transition probability matrix is finding the limit of the transition matrix which is powered by n where n moves to infinity. The convergence form of the transition probability matrix is very interesting as it will bring the matrix to its stationary form. This form is useful for predicting the probability of transitions between states in the future. The method usually used to find the convergence of transition probability matrix is through the process of limiting the distribution. In this paper, the convergence of the transition probability matrix is searched using a simple concept of linear algebra that is by diagonalizing the matrix.This method has a higher level of complexity because it has to perform the process of diagonalization in its matrix. But this way has the advantage of obtaining a common form of power n of the transition probability matrix. This form is useful to see transition matrix before stationary. For example cases are taken from CLV model using MCM called Model of CLV-Markov. There are several models taken by its transition probability matrix to find its convergence form. The result is that the convergence of the matrix of transition probability through diagonalization has similarity with convergence with commonly used distribution of probability limiting method.

  13. Birth/birth-death processes and their computable transition probabilities with biological applications.

    PubMed

    Ho, Lam Si Tung; Xu, Jason; Crawford, Forrest W; Minin, Vladimir N; Suchard, Marc A

    2018-03-01

    Birth-death processes track the size of a univariate population, but many biological systems involve interaction between populations, necessitating models for two or more populations simultaneously. A lack of efficient methods for evaluating finite-time transition probabilities of bivariate processes, however, has restricted statistical inference in these models. Researchers rely on computationally expensive methods such as matrix exponentiation or Monte Carlo approximation, restricting likelihood-based inference to small systems, or indirect methods such as approximate Bayesian computation. In this paper, we introduce the birth/birth-death process, a tractable bivariate extension of the birth-death process, where rates are allowed to be nonlinear. We develop an efficient algorithm to calculate its transition probabilities using a continued fraction representation of their Laplace transforms. Next, we identify several exemplary models arising in molecular epidemiology, macro-parasite evolution, and infectious disease modeling that fall within this class, and demonstrate advantages of our proposed method over existing approaches to inference in these models. Notably, the ubiquitous stochastic susceptible-infectious-removed (SIR) model falls within this class, and we emphasize that computable transition probabilities newly enable direct inference of parameters in the SIR model. We also propose a very fast method for approximating the transition probabilities under the SIR model via a novel branching process simplification, and compare it to the continued fraction representation method with application to the 17th century plague in Eyam. Although the two methods produce similar maximum a posteriori estimates, the branching process approximation fails to capture the correlation structure in the joint posterior distribution.

  14. Application of global kinetic models to HMX beta-delta transition and cookoff processes.

    PubMed

    Wemhoff, Aaron P; Burnham, Alan K; Nichols, Albert L

    2007-03-08

    The reduction of the number of reactions in kinetic models for both the HMX (octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine) beta-delta phase transition and thermal cookoff provides an attractive alternative to traditional multi-stage kinetic models due to reduced calibration effort requirements. In this study, we use the LLNL code ALE3D to provide calibrated kinetic parameters for a two-reaction bidirectional beta-delta HMX phase transition model based on Sandia instrumented thermal ignition (SITI) and scaled thermal explosion (STEX) temperature history curves, and a Prout-Tompkins cookoff model based on one-dimensional time to explosion (ODTX) data. Results show that the two-reaction bidirectional beta-delta transition model presented here agrees as well with STEX and SITI temperature history curves as a reversible four-reaction Arrhenius model yet requires an order of magnitude less computational effort. In addition, a single-reaction Prout-Tompkins model calibrated to ODTX data provides better agreement with ODTX data than a traditional multistep Arrhenius model and can contain up to 90% fewer chemistry-limited time steps for low-temperature ODTX simulations. Manual calibration methods for the Prout-Tompkins kinetics provide much better agreement with ODTX experimental data than parameters derived from differential scanning calorimetry (DSC) measurements at atmospheric pressure. The predicted surface temperature at explosion for STEX cookoff simulations is a weak function of the cookoff model used, and a reduction of up to 15% of chemistry-limited time steps can be achieved by neglecting the beta-delta transition for this type of simulation. Finally, the inclusion of the beta-delta transition model in the overall kinetics model can affect the predicted time to explosion by 1% for the traditional multistep Arrhenius approach, and up to 11% using a Prout-Tompkins cookoff model.

  15. Method of transition from 3D model to its ontological representation in aircraft design process

    NASA Astrophysics Data System (ADS)

    Govorkov, A. S.; Zhilyaev, A. S.; Fokin, I. V.

    2018-05-01

    This paper proposes the method of transition from a 3D model to its ontological representation and describes its usage in the aircraft design process. The problems of design for manufacturability and design automation are also discussed. The introduced method is to aim to ease the process of data exchange between important aircraft design phases, namely engineering and design control. The method is also intended to increase design speed and 3D model customizability. This requires careful selection of the complex systems (CAD / CAM / CAE / PDM), providing the basis for the integration of design and technological preparation of production and more fully take into account the characteristics of products and processes for their manufacture. It is important to solve this problem, as investment in the automation define the company's competitiveness in the years ahead.

  16. A stress-induced phase transition model for semi-crystallize shape memory polymer

    NASA Astrophysics Data System (ADS)

    Guo, Xiaogang; Zhou, Bo; Liu, Liwu; Liu, Yanju; Leng, Jinsong

    2014-03-01

    The developments of constitutive models for shape memory polymer (SMP) have been motivated by its increasing applications. During cooling or heating process, the phase transition which is a continuous time-dependent process happens in semi-crystallize SMP and the various individual phases form at different temperature and in different configuration. Then, the transformation between these phases occurred and shape memory effect will emerge. In addition, stress applied on SMP is an important factor for crystal melting during phase transition. In this theory, an ideal phase transition model considering stress or pre-strain is the key to describe the behaviors of shape memory effect. So a normal distributed model was established in this research to characterize the volume fraction of each phase in SMP during phase transition. Generally, the experiment results are partly backward (in heating process) or forward (in cooling process) compared with the ideal situation considering delay effect during phase transition. So, a correction on the normal distributed model is needed. Furthermore, a nonlinear relationship between stress and phase transition temperature Tg is also taken into account for establishing an accurately normal distributed phase transition model. Finally, the constitutive model which taking the stress as an influence factor on phase transition was also established. Compared with the other expressions, this new-type model possesses less parameter and is more accurate. For the sake of verifying the rationality and accuracy of new phase transition and constitutive model, the comparisons between the simulated and experimental results were carried out.

  17. Hybrid Percolation Transition in Cluster Merging Processes: Continuously Varying Exponents

    NASA Astrophysics Data System (ADS)

    Cho, Y. S.; Lee, J. S.; Herrmann, H. J.; Kahng, B.

    2016-01-01

    Consider growing a network, in which every new connection is made between two disconnected nodes. At least one node is chosen randomly from a subset consisting of g fraction of the entire population in the smallest clusters. Here we show that this simple strategy for improving connection exhibits a more unusual phase transition, namely a hybrid percolation transition exhibiting the properties of both first-order and second-order phase transitions. The cluster size distribution of finite clusters at a transition point exhibits power-law behavior with a continuously varying exponent τ in the range 2 <τ (g )≤2.5 . This pattern reveals a necessary condition for a hybrid transition in cluster aggregation processes, which is comparable to the power-law behavior of the avalanche size distribution arising in models with link-deleting processes in interdependent networks.

  18. Efficient Transition Probability Computation for Continuous-Time Branching Processes via Compressed Sensing.

    PubMed

    Xu, Jason; Minin, Vladimir N

    2015-07-01

    Branching processes are a class of continuous-time Markov chains (CTMCs) with ubiquitous applications. A general difficulty in statistical inference under partially observed CTMC models arises in computing transition probabilities when the discrete state space is large or uncountable. Classical methods such as matrix exponentiation are infeasible for large or countably infinite state spaces, and sampling-based alternatives are computationally intensive, requiring integration over all possible hidden events. Recent work has successfully applied generating function techniques to computing transition probabilities for linear multi-type branching processes. While these techniques often require significantly fewer computations than matrix exponentiation, they also become prohibitive in applications with large populations. We propose a compressed sensing framework that significantly accelerates the generating function method, decreasing computational cost up to a logarithmic factor by only assuming the probability mass of transitions is sparse. We demonstrate accurate and efficient transition probability computations in branching process models for blood cell formation and evolution of self-replicating transposable elements in bacterial genomes.

  19. Efficient Transition Probability Computation for Continuous-Time Branching Processes via Compressed Sensing

    PubMed Central

    Xu, Jason; Minin, Vladimir N.

    2016-01-01

    Branching processes are a class of continuous-time Markov chains (CTMCs) with ubiquitous applications. A general difficulty in statistical inference under partially observed CTMC models arises in computing transition probabilities when the discrete state space is large or uncountable. Classical methods such as matrix exponentiation are infeasible for large or countably infinite state spaces, and sampling-based alternatives are computationally intensive, requiring integration over all possible hidden events. Recent work has successfully applied generating function techniques to computing transition probabilities for linear multi-type branching processes. While these techniques often require significantly fewer computations than matrix exponentiation, they also become prohibitive in applications with large populations. We propose a compressed sensing framework that significantly accelerates the generating function method, decreasing computational cost up to a logarithmic factor by only assuming the probability mass of transitions is sparse. We demonstrate accurate and efficient transition probability computations in branching process models for blood cell formation and evolution of self-replicating transposable elements in bacterial genomes. PMID:26949377

  20. Application of a tablet film coating model to define a process-imposed transition boundary for robust film coating.

    PubMed

    van den Ban, Sander; Pitt, Kendal G; Whiteman, Marshall

    2018-02-01

    A scientific understanding of interaction of product, film coat, film coating process, and equipment is important to enable design and operation of industrial scale pharmaceutical film coating processes that are robust and provide the level of control required to consistently deliver quality film coated product. Thermodynamic film coating conditions provided in the tablet film coating process impact film coat formation and subsequent product quality. A thermodynamic film coating model was used to evaluate film coating process performance over a wide range of film coating equipment from pilot to industrial scale (2.5-400 kg). An approximate process-imposed transition boundary, from operating in a dry to a wet environment, was derived, for relative humidity and exhaust temperature, and used to understand the impact of the film coating process on product formulation and process control requirements. This approximate transition boundary may aid in an enhanced understanding of risk to product quality, application of modern Quality by Design (QbD) based product development, technology transfer and scale-up, and support the science-based justification of critical process parameters (CPPs).

  1. The Work of Cultural Transition: An Emerging Model

    PubMed Central

    Ryba, Tatiana V.; Stambulova, Natalia B.; Ronkainen, Noora J.

    2016-01-01

    In today’s uncertain, fluid job market, transnational mobility has intensified. Though the concept of cultural transition is increasingly used in sport and career research, insight into the processes of how individuals produce their own development through work and relationships in shifting cultural patterns of meaning remains limited. The transnational industry of sports, in which athletes’ psychological adjustment to cultural transitions has implications for both performance and meaningful life, serves as a backdrop for this article. This study applied the life story method to interviews with 15 professional and semi-professional athletes, focusing particularly on the cultural transition aspect of their transnational athletic careers. The aims of the study were to identify the developmental tasks of cultural transitions and strategies/mechanisms through which cultural transitions were enacted. Three underlying mechanisms of the transition process that assisted athletic career adaptability were social repositioning, negotiation of cultural practices, and meaning reconstruction. Based on the data analyses, a temporal model of cultural transition is proposed. The results of this research provide professionals working in the fields of career counseling and migrant support with a content framework for enhancing migrant workers’ adaptabilities and psychological wellbeing. PMID:27047436

  2. Analytic Scattering and Refraction Models for Exoplanet Transit Spectra

    NASA Astrophysics Data System (ADS)

    Robinson, Tyler D.; Fortney, Jonathan J.; Hubbard, William B.

    2017-12-01

    Observations of exoplanet transit spectra are essential to understanding the physics and chemistry of distant worlds. The effects of opacity sources and many physical processes combine to set the shape of a transit spectrum. Two such key processes—refraction and cloud and/or haze forward-scattering—have seen substantial recent study. However, models of these processes are typically complex, which prevents their incorporation into observational analyses and standard transit spectrum tools. In this work, we develop analytic expressions that allow for the efficient parameterization of forward-scattering and refraction effects in transit spectra. We derive an effective slant optical depth that includes a correction for forward-scattered light, and present an analytic form of this correction. We validate our correction against a full-physics transit spectrum model that includes scattering, and we explore the extent to which the omission of forward-scattering effects may bias models. Also, we verify a common analytic expression for the location of a refractive boundary, which we express in terms of the maximum pressure probed in a transit spectrum. This expression is designed to be easily incorporated into existing tools, and we discuss how the detection of a refractive boundary could help indicate the background atmospheric composition by constraining the bulk refractivity of the atmosphere. Finally, we show that opacity from Rayleigh scattering and collision-induced absorption will outweigh the effects of refraction for Jupiter-like atmospheres whose equilibrium temperatures are above 400-500 K.

  3. Implementation and Validation of a Laminar-to-Turbulent Transition Model in the Wind-US Code

    NASA Technical Reports Server (NTRS)

    Denissen, Nicholas A.; Yoder, Dennis A.; Georgiadis, Nicholas J.

    2008-01-01

    A bypass transition model has been implemented in the Wind-US Reynolds Averaged Navier-Stokes (RANS) solver. The model is based on the Shear Stress Transport (SST) turbulence model and was built starting from a previous SST-based transition model. Several modifications were made to enable (1) consistent solutions regardless of flow field initialization procedure and (2) fully turbulent flow beyond the transition region. This model is intended for flows where bypass transition, in which the transition process is dominated by large freestream disturbances, is the key transition mechanism as opposed to transition dictated by modal growth. Validation of the new transition model is performed for flows ranging from incompressible to hypersonic conditions.

  4. Introducing Modeling Transition Diagrams as a Tool to Connect Mathematical Modeling to Mathematical Thinking

    ERIC Educational Resources Information Center

    Czocher, Jennifer A.

    2016-01-01

    This study contributes a methodological tool to reconstruct the cognitive processes and mathematical activities carried out by mathematical modelers. Represented as Modeling Transition Diagrams (MTDs), individual modeling routes were constructed for four engineering undergraduate students. Findings stress the importance and limitations of using…

  5. Epidemic models for phase transitions: application to a physical gel

    NASA Astrophysics Data System (ADS)

    Bilge, A. H.; Pekcan, O.; Kara, S.; Ogrenci, A. S.

    2017-09-01

    Carrageenan gels are characterized by reversible sol-gel and gel-sol transitions under cooling and heating processes and these transitions are approximated by generalized logistic growth curves. We express the transitions of carrageenan-water system, as a representative of reversible physical gels, in terms of a modified Susceptible-Infected-Susceptible epidemic model, as opposed to the Susceptible-Infected-Removed model used to represent the (irreversible) chemical gel formation in the previous work. We locate the gel point Tc of sol-gel and gel-sol transitions and we find that, for the sol-gel transition (cooling), Tc > Tsg (transition temperature), i.e. Tc is earlier in time for all carrageenan contents and moves forward in time and gets closer to Tsg as the carrageenan content increases. For the gel-sol transition (heating), Tc is relatively closer to Tgs; it is greater than Tgs, i.e. later in time for low carrageenan contents and moves backward as carrageenan content increases.

  6. Semiclassical theory of electronically nonadiabatic transitions in molecular collision processes

    NASA Technical Reports Server (NTRS)

    Lam, K. S.; George, T. F.

    1979-01-01

    An introductory account of the semiclassical theory of the S-matrix for molecular collision processes is presented, with special emphasis on electronically nonadiabatic transitions. This theory is based on the incorporation of classical mechanics with quantum superposition, and in practice makes use of the analytic continuation of classical mechanics into the complex space of time domain. The relevant concepts of molecular scattering theory and related dynamical models are described and the formalism is developed and illustrated with simple examples - collinear collision of the A+BC type. The theory is then extended to include the effects of laser-induced nonadiabatic transitions. Two bound continuum processes collisional ionization and collision-induced emission also amenable to the same general semiclassical treatment are discussed.

  7. Modeling of transitional flows

    NASA Technical Reports Server (NTRS)

    Lund, Thomas S.

    1988-01-01

    An effort directed at developing improved transitional models was initiated. The focus of this work was concentrated on the critical assessment of a popular existing transitional model developed by McDonald and Fish in 1972. The objective of this effort was to identify the shortcomings of the McDonald-Fish model and to use the insights gained to suggest modifications or alterations of the basic model. In order to evaluate the transitional model, a compressible boundary layer code was required. Accordingly, a two-dimensional compressible boundary layer code was developed. The program was based on a three-point fully implicit finite difference algorithm where the equations were solved in an uncoupled manner with second order extrapolation used to evaluate the non-linear coefficients. Iteration was offered as an option if the extrapolation error could not be tolerated. The differencing scheme was arranged to be second order in both spatial directions on an arbitrarily stretched mesh. A variety of boundary condition options were implemented including specification of an external pressure gradient, specification of a wall temperature distribution, and specification of an external temperature distribution. Overall the results of the initial phase of this work indicate that the McDonald-Fish model does a poor job at predicting the details of the turbulent flow structure during the transition region.

  8. Modelling the transitional boundary layer

    NASA Technical Reports Server (NTRS)

    Narasimha, R.

    1990-01-01

    Recent developments in the modelling of the transition zone in the boundary layer are reviewed (the zone being defined as extending from the station where intermittency begins to depart from zero to that where it is nearly unity). The value of using a new non-dimensional spot formation rate parameter, and the importance of allowing for so-called subtransitions within the transition zone, are both stressed. Models do reasonably well in constant pressure 2-dimensional flows, but in the presence of strong pressure gradients further improvements are needed. The linear combination approach works surprisingly well in most cases, but would not be so successful in situations where a purely laminar boundary layer would separate but a transitional one would not. Intermittency-weighted eddy viscosity methods do not predict peak surface parameters well without the introduction of an overshooting transition function whose connection with the spot theory of transition is obscure. Suggestions are made for further work that now appears necessary for developing improved models of the transition zone.

  9. Mass fractionation processes of transition metal isotopes

    NASA Astrophysics Data System (ADS)

    Zhu, X. K.; Guo, Y.; Williams, R. J. P.; O'Nions, R. K.; Matthews, A.; Belshaw, N. S.; Canters, G. W.; de Waal, E. C.; Weser, U.; Burgess, B. K.; Salvato, B.

    2002-06-01

    Recent advances in mass spectrometry make it possible to utilise isotope variations of transition metals to address some important issues in solar system and biological sciences. Realisation of the potential offered by these new isotope systems however requires an adequate understanding of the factors controlling their isotope fractionation. Here we show the results of a broadly based study on copper and iron isotope fractionation during various inorganic and biological processes. These results demonstrate that: (1) naturally occurring inorganic processes can fractionate Fe isotope to a detectable level even at temperature ˜1000°C, which challenges the previous view that Fe isotope variations in natural system are unique biosignatures; (2) multiple-step equilibrium processes at low temperatures may cause large mass fractionation of transition metal isotopes even when the fractionation per single step is small; (3) oxidation-reduction is an importation controlling factor of isotope fractionation of transition metal elements with multiple valences, which opens a wide range of applications of these new isotope systems, ranging from metal-silicate fractionation in the solar system to uptake pathways of these elements in biological systems; (4) organisms incorporate lighter isotopes of transition metals preferentially, and transition metal isotope fractionation occurs stepwise along their pathways within biological systems during their uptake.

  10. Computer models of social processes: the case of migration.

    PubMed

    Beshers, J M

    1967-06-01

    The demographic model is a program for representing births, deaths, migration, and social mobility as social processes in a non-stationary stochastic process (Markovian). Transition probabilities for each age group are stored and then retrieved at the next appearance of that age cohort. In this way new transition probabilities can be calculated as a function of the old transition probabilities and of two successive distribution vectors.Transition probabilities can be calculated to represent effects of the whole age-by-state distribution at any given time period, too. Such effects as saturation or queuing may be represented by a market mechanism; for example, migration between metropolitan areas can be represented as depending upon job supplies and labor markets. Within metropolitan areas, migration can be represented as invasion and succession processes with tipping points (acceleration curves), and the market device has been extended to represent this phenomenon.Thus, the demographic model makes possible the representation of alternative classes of models of demographic processes. With each class of model one can deduce implied time series (varying parame-terswithin the class) and the output of the several classes can be compared to each other and to outside criteria, such as empirical time series.

  11. Detecting critical state before phase transition of complex systems by hidden Markov model

    NASA Astrophysics Data System (ADS)

    Liu, Rui; Chen, Pei; Li, Yongjun; Chen, Luonan

    Identifying the critical state or pre-transition state just before the occurrence of a phase transition is a challenging task, because the state of the system may show little apparent change before this critical transition during the gradual parameter variations. Such dynamics of phase transition is generally composed of three stages, i.e., before-transition state, pre-transition state, and after-transition state, which can be considered as three different Markov processes. Thus, based on this dynamical feature, we present a novel computational method, i.e., hidden Markov model (HMM), to detect the switching point of the two Markov processes from the before-transition state (a stationary Markov process) to the pre-transition state (a time-varying Markov process), thereby identifying the pre-transition state or early-warning signals of the phase transition. To validate the effectiveness, we apply this method to detect the signals of the imminent phase transitions of complex systems based on the simulated datasets, and further identify the pre-transition states as well as their critical modules for three real datasets, i.e., the acute lung injury triggered by phosgene inhalation, MCF-7 human breast cancer caused by heregulin, and HCV-induced dysplasia and hepatocellular carcinoma.

  12. Nonlinear process in the mode transition in typical strut-based and cavity-strut based scramjet combustors

    NASA Astrophysics Data System (ADS)

    Yan, Li; Liao, Lei; Huang, Wei; Li, Lang-quan

    2018-04-01

    The analysis of nonlinear characteristics and control of mode transition process is the crucial issue to enhance the stability and reliability of the dual-mode scramjet engine. In the current study, the mode transition processes in both strut-based combustor and cavity-strut based combustor are numerically studied, and the influence of the cavity on the transition process is analyzed in detail. The simulations are conducted by means of the Reynolds averaged Navier-Stokes (RANS) equations coupled with the renormalization group (RNG) k-ε turbulence model and the single-step chemical reaction mechanism, and this numerical approach is proved to be valid by comparing the predicted results with the available experimental shadowgraphs in the open literature. During the mode transition process, an obvious nonlinear property is observed, namely the unevenly variations of pressure along the combustor. The hysteresis phenomenon is more obvious upstream of the flow field. For the cavity-strut configuration, the whole flow field is more inclined to the supersonic state during the transition process, and it is uneasy to convert to the ramjet mode. In the scram-to-ram transition process, the process would be more stable, and the hysteresis effect would be reduced in the ram-to-scram transition process.

  13. Camera-Model Identification Using Markovian Transition Probability Matrix

    NASA Astrophysics Data System (ADS)

    Xu, Guanshuo; Gao, Shang; Shi, Yun Qing; Hu, Ruimin; Su, Wei

    Detecting the (brands and) models of digital cameras from given digital images has become a popular research topic in the field of digital forensics. As most of images are JPEG compressed before they are output from cameras, we propose to use an effective image statistical model to characterize the difference JPEG 2-D arrays of Y and Cb components from the JPEG images taken by various camera models. Specifically, the transition probability matrices derived from four different directional Markov processes applied to the image difference JPEG 2-D arrays are used to identify statistical difference caused by image formation pipelines inside different camera models. All elements of the transition probability matrices, after a thresholding technique, are directly used as features for classification purpose. Multi-class support vector machines (SVM) are used as the classification tool. The effectiveness of our proposed statistical model is demonstrated by large-scale experimental results.

  14. From bedside to classroom: the nurse educator transition model.

    PubMed

    Schoening, Anne M

    2013-01-01

    The purpose of this qualitative study was to generate a theoretical model that describes the social process that occurs during the role transition from nurse to nurse educator. Recruitment and retention of qualified nurse educators is essential in order to remedy the current staff nurse and faculty shortage in the United States, yet nursing schools face many challenges in this area. This grounded theory study utilized purposive, theoretical sampling to identify 20 nurse educators teaching in baccalaureate nursing programs in the Midwest. The Nurse Educator Transition (NET) model was created from these data.This model identifies four phases in the role transition from nurse to nurse educator: a) the Anticipatory/Expectation Phase, b) the Disorientation Phase, c) the Information-Seeking Phase, and d) the Identity Formation Phase. Recommendations include integrating formal pedagogical education into nursing graduate programs and creating evidence-based orientation and mentoring programs for novice nurse faculty.

  15. Synthesis of Individual Transition Plans: Format and Process.

    ERIC Educational Resources Information Center

    La Mar, Kathleen; Rosenberg, Bill

    This document presents a prototype Individual Transition Plan (ITP) process and format for students receiving special education services. Following an overview of the role of transition, a section on the ITP process discusses pre-meeting activities, conducting an ITP meeting, monitoring and evaluating the ITP meeting, and a rationale for the…

  16. Markov-chain model of classified atomistic transition states for discrete kinetic Monte Carlo simulations.

    PubMed

    Numazawa, Satoshi; Smith, Roger

    2011-10-01

    Classical harmonic transition state theory is considered and applied in discrete lattice cells with hierarchical transition levels. The scheme is then used to determine transitions that can be applied in a lattice-based kinetic Monte Carlo (KMC) atomistic simulation model. The model results in an effective reduction of KMC simulation steps by utilizing a classification scheme of transition levels for thermally activated atomistic diffusion processes. Thermally activated atomistic movements are considered as local transition events constrained in potential energy wells over certain local time periods. These processes are represented by Markov chains of multidimensional Boolean valued functions in three-dimensional lattice space. The events inhibited by the barriers under a certain level are regarded as thermal fluctuations of the canonical ensemble and accepted freely. Consequently, the fluctuating system evolution process is implemented as a Markov chain of equivalence class objects. It is shown that the process can be characterized by the acceptance of metastable local transitions. The method is applied to a problem of Au and Ag cluster growth on a rippled surface. The simulation predicts the existence of a morphology-dependent transition time limit from a local metastable to stable state for subsequent cluster growth by accretion. Excellent agreement with observed experimental results is obtained.

  17. Prediction and Analysis of the Nonsteady Transition and Separation Processes on an Oscillating Wind Turbine Airfoil using the \\gamma-Re_\\theta Transition Model.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Nandi, Taraj; Brasseur, James; Vijayakumar, Ganesh

    2016-01-04

    This study is aimed at gaining insight into the nonsteady transitional boundary layer dynamics of wind turbine blades and the predictive capabilities of URANS based transition and turbulence models for similar physics through the analysis of a controlled flow with similar nonsteady parameters.

  18. A Correlation-Based Transition Model using Local Variables. Part 2; Test Cases and Industrial Applications

    NASA Technical Reports Server (NTRS)

    Langtry, R. B.; Menter, F. R.; Likki, S. R.; Suzen, Y. B.; Huang, P. G.; Volker, S.

    2006-01-01

    A new correlation-based transition model has been developed, which is built strictly on local variables. As a result, the transition model is compatible with modern computational fluid dynamics (CFD) methods using unstructured grids and massive parallel execution. The model is based on two transport equations, one for the intermittency and one for the transition onset criteria in terms of momentum thickness Reynolds number. The proposed transport equations do not attempt to model the physics of the transition process (unlike, e.g., turbulence models), but form a framework for the implementation of correlation-based models into general-purpose CFD methods.

  19. Mental models accurately predict emotion transitions.

    PubMed

    Thornton, Mark A; Tamir, Diana I

    2017-06-06

    Successful social interactions depend on people's ability to predict others' future actions and emotions. People possess many mechanisms for perceiving others' current emotional states, but how might they use this information to predict others' future states? We hypothesized that people might capitalize on an overlooked aspect of affective experience: current emotions predict future emotions. By attending to regularities in emotion transitions, perceivers might develop accurate mental models of others' emotional dynamics. People could then use these mental models of emotion transitions to predict others' future emotions from currently observable emotions. To test this hypothesis, studies 1-3 used data from three extant experience-sampling datasets to establish the actual rates of emotional transitions. We then collected three parallel datasets in which participants rated the transition likelihoods between the same set of emotions. Participants' ratings of emotion transitions predicted others' experienced transitional likelihoods with high accuracy. Study 4 demonstrated that four conceptual dimensions of mental state representation-valence, social impact, rationality, and human mind-inform participants' mental models. Study 5 used 2 million emotion reports on the Experience Project to replicate both of these findings: again people reported accurate models of emotion transitions, and these models were informed by the same four conceptual dimensions. Importantly, neither these conceptual dimensions nor holistic similarity could fully explain participants' accuracy, suggesting that their mental models contain accurate information about emotion dynamics above and beyond what might be predicted by static emotion knowledge alone.

  20. Mental models accurately predict emotion transitions

    PubMed Central

    Thornton, Mark A.; Tamir, Diana I.

    2017-01-01

    Successful social interactions depend on people’s ability to predict others’ future actions and emotions. People possess many mechanisms for perceiving others’ current emotional states, but how might they use this information to predict others’ future states? We hypothesized that people might capitalize on an overlooked aspect of affective experience: current emotions predict future emotions. By attending to regularities in emotion transitions, perceivers might develop accurate mental models of others’ emotional dynamics. People could then use these mental models of emotion transitions to predict others’ future emotions from currently observable emotions. To test this hypothesis, studies 1–3 used data from three extant experience-sampling datasets to establish the actual rates of emotional transitions. We then collected three parallel datasets in which participants rated the transition likelihoods between the same set of emotions. Participants’ ratings of emotion transitions predicted others’ experienced transitional likelihoods with high accuracy. Study 4 demonstrated that four conceptual dimensions of mental state representation—valence, social impact, rationality, and human mind—inform participants’ mental models. Study 5 used 2 million emotion reports on the Experience Project to replicate both of these findings: again people reported accurate models of emotion transitions, and these models were informed by the same four conceptual dimensions. Importantly, neither these conceptual dimensions nor holistic similarity could fully explain participants’ accuracy, suggesting that their mental models contain accurate information about emotion dynamics above and beyond what might be predicted by static emotion knowledge alone. PMID:28533373

  1. The Biological Big Bang model for the major transitions in evolution.

    PubMed

    Koonin, Eugene V

    2007-08-20

    Major transitions in biological evolution show the same pattern of sudden emergence of diverse forms at a new level of complexity. The relationships between major groups within an emergent new class of biological entities are hard to decipher and do not seem to fit the tree pattern that, following Darwin's original proposal, remains the dominant description of biological evolution. The cases in point include the origin of complex RNA molecules and protein folds; major groups of viruses; archaea and bacteria, and the principal lineages within each of these prokaryotic domains; eukaryotic supergroups; and animal phyla. In each of these pivotal nexuses in life's history, the principal "types" seem to appear rapidly and fully equipped with the signature features of the respective new level of biological organization. No intermediate "grades" or intermediate forms between different types are detectable. Usually, this pattern is attributed to cladogenesis compressed in time, combined with the inevitable erosion of the phylogenetic signal. I propose that most or all major evolutionary transitions that show the "explosive" pattern of emergence of new types of biological entities correspond to a boundary between two qualitatively distinct evolutionary phases. The first, inflationary phase is characterized by extremely rapid evolution driven by various processes of genetic information exchange, such as horizontal gene transfer, recombination, fusion, fission, and spread of mobile elements. These processes give rise to a vast diversity of forms from which the main classes of entities at the new level of complexity emerge independently, through a sampling process. In the second phase, evolution dramatically slows down, the respective process of genetic information exchange tapers off, and multiple lineages of the new type of entities emerge, each of them evolving in a tree-like fashion from that point on. This biphasic model of evolution incorporates the previously developed

  2. Modeling of near wall turbulence and modeling of bypass transition

    NASA Technical Reports Server (NTRS)

    Yang, Z.

    1992-01-01

    The objectives for this project are as follows: (1) Modeling of the near wall turbulence: We aim to develop a second order closure for the near wall turbulence. As a first step of this project, we try to develop a kappa-epsilon model for near wall turbulence. We require the resulting model to be able to handle both near wall turbulence and turbulent flows away from the wall, computationally robust, and applicable for complex flow situations, flow with separation, for example, and (2) Modeling of the bypass transition: We aim to develop a bypass transition model which contains the effect of intermittency. Thus, the model can be used for both the transitional boundary layers and the turbulent boundary layers. We require the resulting model to give a good prediction of momentum and heat transfer within the transitional boundary and a good prediction of the effect of freestream turbulence on transitional boundary layers.

  3. Simulation of dynamic processes when machining transition surfaces of stepped shafts

    NASA Astrophysics Data System (ADS)

    Maksarov, V. V.; Krasnyy, V. A.; Viushin, R. V.

    2018-03-01

    The paper addresses the characteristics of stepped surfaces of parts categorized as "solids of revolution". It is noted that in the conditions of transition modes during the switch to end surface machining, there is cutting with varied load intensity in the section of the cut layer, which leads to change in cutting force, onset of vibrations, an increase in surface layer roughness, a decrease of size precision, and increased wear of a tool's cutting edge. This work proposes a method that consists in developing a CNC program output code that allows one to process complex forms of stepped shafts with only one machine setup. The authors developed and justified a mathematical model of a technological system for mechanical processing with consideration for the resolution of tool movement at the stages of transition processes to assess the dynamical stability of a system in the process of manufacturing stepped surfaces of parts of “solid of revolution” type.

  4. State-and-transition simulation models: a framework for forecasting landscape change

    USGS Publications Warehouse

    Daniel, Colin; Frid, Leonardo; Sleeter, Benjamin M.; Fortin, Marie-Josée

    2016-01-01

    SummaryA wide range of spatially explicit simulation models have been developed to forecast landscape dynamics, including models for projecting changes in both vegetation and land use. While these models have generally been developed as separate applications, each with a separate purpose and audience, they share many common features.We present a general framework, called a state-and-transition simulation model (STSM), which captures a number of these common features, accompanied by a software product, called ST-Sim, to build and run such models. The STSM method divides a landscape into a set of discrete spatial units and simulates the discrete state of each cell forward as a discrete-time-inhomogeneous stochastic process. The method differs from a spatially interacting Markov chain in several important ways, including the ability to add discrete counters such as age and time-since-transition as state variables, to specify one-step transition rates as either probabilities or target areas, and to represent multiple types of transitions between pairs of states.We demonstrate the STSM method using a model of land-use/land-cover (LULC) change for the state of Hawai'i, USA. Processes represented in this example include expansion/contraction of agricultural lands, urbanization, wildfire, shrub encroachment into grassland and harvest of tree plantations; the model also projects shifts in moisture zones due to climate change. Key model output includes projections of the future spatial and temporal distribution of LULC classes and moisture zones across the landscape over the next 50 years.State-and-transition simulation models can be applied to a wide range of landscapes, including questions of both land-use change and vegetation dynamics. Because the method is inherently stochastic, it is well suited for characterizing uncertainty in model projections. When combined with the ST-Sim software, STSMs offer a simple yet powerful means for developing a wide range of models of

  5. Kinetic synergistic transitions in the Ostwald ripening processes

    NASA Astrophysics Data System (ADS)

    Sachkov, I. N.; Turygina, V. F.; Dolganov, A. N.

    2018-01-01

    There is proposed approach to mathematical description of the kinetic transitions in Ostwald ripening processes of volatile substance in nonuniformly heated porous materials. It is based upon the finite element method. There are implemented computer software. The main feature of the software is to calculate evaporation and condensation fluxes on the walls of a nonuniformly heated cylindrical capillary. Kinetic transitions are detected for three modes of volatile substances migration which are different by condensation zones location. There are controlling dimensionless parameters of the kinetic transition which are revealed during research. There is phase diagram of the Ostwald ripening process modes realization.

  6. Socio-technical transition as a co-evolutionary process: Innovation and the role of niche markets in the transition to motor vehicles

    NASA Astrophysics Data System (ADS)

    Birky, Alicia K.

    2008-10-01

    Significant reductions in greenhouse emissions from personal transportation will require a transition to an alternative technology regime based on renewable energy sources. Two bodies of research, the quasi-evolutionary (QE) model and the multi-level perspective (MLP) assert that processes within niches play a fundamental role in such transitions. This research asks whether the description of transitions based on this niche hypothesis and its underlying assumptions is consistent with the historical U.S. transition to motor vehicles at the beginning of the 20th century. Unique to this dissertation is the combination of the perspective of the entrepreneur with co-evolutionary approaches to socio-technical transitions. This approach is augmented with concepts from the industry life-cycle model and with a taxonomy of mechanisms of learning. Using this analytic framework, I examine specifically the role of entrepreneurial behavior and processes within and among firms in the co-evolution of technologies and institutions during the transition to motor vehicles. I find that niche markets played an important role in the development of the technology, institutions, and the industry. However, I also find that the diffusion of the automobile is not consistent with the niche hypothesis in the following ways: (1) product improvements and cost reductions were not realized in niche markets, but were achieved simultaneously with diffusion into mass markets; (2) in addition to learning-by-doing and learning-by-interacting with users, knowledge spillovers and interacting with suppliers were critical in this process; (3) cost reductions were not automatic results of expanding markets, but rather arose from the strategies of entrepreneurs based on personal perspectives and values. This finding supports the use of a behavioral approach with a micro-focus in the analysis of socio-technical change. I also find that the emergence and diffusion of the motor vehicle can only be understood by

  7. Chaos Theory as a Model for Life Transitions Counseling: Nonlinear Dynamics and Life's Changes

    ERIC Educational Resources Information Center

    Bussolari, Cori J.; Goodell, Judith A.

    2009-01-01

    Chaos theory is presented for counselors working with clients experiencing life transitions. It is proposed as a model that considers disorder, unpredictability, and lack of control as normal parts of transition processes. Nonlinear constructs from physics are adapted for use in counseling. The model provides a method clients can use to…

  8. [The transition process from paediatric to adult services: A perspective from hospitalised adolescent sufferers of chronic diseases].

    PubMed

    Inostroza Quezada, Carolina; Correa Venegas, María Loreto; Besoain Arrau, Carolina; Reinoso Medinelli, Alejandro; Velarde Lizama, Macarena; Valenzuela Mujica, María Teresa; Bedregal García, Paula; Zubarew Gurtchin, Tamara

    2016-01-01

    Chronic illnesses during adolescence are a big challenge for the patient, his or her family, and health care providers. The transition from paediatric health services to adult health services involves a programmed and planned transfer process of adolescent sufferers of chronic illnesses, in order to maintain a high quality of life and bio-psycho-social development. There is currently no transition model. The objective of the study is to understand the transition process from the perspective of hospitalised adolescents to collaborate towards the design of a model that meets the needs studied. Semi-structured interviews with 13 adolescent sufferers of chronic illnesses, hospitalised in two healthcare centres in Santiago, Chile, in one analytical-relational study, supported by qualitative methodology. In the analysis, 5 major themes stand out: experience of living with the illness, the importance of the doctor-patient relationship, the concept of limited autonomy to the pharmacology, the absence of the transition process as such, and the identification of barriers and needs for an adequate transition. This study is new in Chile in that it explores the phenomenom of the transition of adolescents with chronic illnesses. It emphasises the need to reinforce the concept of self-care and autonomy from early stages of care, and the importance of early planning of a healthy transition process, in accordance to the detected needs of the adolescents themselves. Copyright © 2015. Publicado por Elsevier España, S.L.U.

  9. Software Transition Project Retrospectives and the Application of SEL Effort Estimation Model and Boehm's COCOMO to Complex Software Transition Projects

    NASA Technical Reports Server (NTRS)

    McNeill, Justin

    1995-01-01

    The Multimission Image Processing Subsystem (MIPS) at the Jet Propulsion Laboratory (JPL) has managed transitions of application software sets from one operating system and hardware platform to multiple operating systems and hardware platforms. As a part of these transitions, cost estimates were generated from the personal experience of in-house developers and managers to calculate the total effort required for such projects. Productivity measures have been collected for two such transitions, one very large and the other relatively small in terms of source lines of code. These estimates used a cost estimation model similar to the Software Engineering Laboratory (SEL) Effort Estimation Model. Experience in transitioning software within JPL MIPS have uncovered a high incidence of interface complexity. Interfaces, both internal and external to individual software applications, have contributed to software transition project complexity, and thus to scheduling difficulties and larger than anticipated design work on software to be ported.

  10. Correlation-based Transition Modeling for External Aerodynamic Flows

    NASA Astrophysics Data System (ADS)

    Medida, Shivaji

    Conventional turbulence models calibrated for fully turbulent boundary layers often over-predict drag and heat transfer on aerodynamic surfaces with partially laminar boundary layers. A robust correlation-based model is developed for use in Reynolds-Averaged Navier-Stokes simulations to predict laminar-to-turbulent transition onset of boundary layers on external aerodynamic surfaces. The new model is derived from an existing transition model for the two-equation k-omega Shear Stress Transport (SST) turbulence model, and is coupled with the one-equation Spalart-Allmaras (SA) turbulence model. The transition model solves two transport equations for intermittency and transition momentum thickness Reynolds number. Experimental correlations and local mean flow quantities are used in the model to account for effects of freestream turbulence level and pressure gradients on transition onset location. Transition onset is triggered by activating intermittency production using a vorticity Reynolds number criterion. In the new model, production and destruction terms of the intermittency equation are modified to improve consistency in the fully turbulent boundary layer post-transition onset, as well as ensure insensitivity to freestream eddy viscosity value specified in the SA model. In the original model, intermittency was used to control production and destruction of turbulent kinetic energy. Whereas, in the new model, only the production of eddy viscosity in SA model is controlled, and the destruction term is not altered. Unlike the original model, the new model does not use an additional correction to intermittency for separation-induced transition. Accuracy of drag predictions are improved significantly with the use of the transition model for several two-dimensional single- and multi-element airfoil cases over a wide range of Reynolds numbers. The new model is able to predict the formation of stable and long laminar separation bubbles on low-Reynolds number airfoils that

  11. Mixed-order phase transition in a one-dimensional model.

    PubMed

    Bar, Amir; Mukamel, David

    2014-01-10

    We introduce and analyze an exactly soluble one-dimensional Ising model with long range interactions that exhibits a mixed-order transition, namely a phase transition in which the order parameter is discontinuous as in first order transitions while the correlation length diverges as in second order transitions. Such transitions are known to appear in a diverse classes of models that are seemingly unrelated. The model we present serves as a link between two classes of models that exhibit a mixed-order transition in one dimension, namely, spin models with a coupling constant that decays as the inverse distance squared and models of depinning transitions, thus making a step towards a unifying framework.

  12. Transition-Independent Decentralized Markov Decision Processes

    NASA Technical Reports Server (NTRS)

    Becker, Raphen; Silberstein, Shlomo; Lesser, Victor; Goldman, Claudia V.; Morris, Robert (Technical Monitor)

    2003-01-01

    There has been substantial progress with formal models for sequential decision making by individual agents using the Markov decision process (MDP). However, similar treatment of multi-agent systems is lacking. A recent complexity result, showing that solving decentralized MDPs is NEXP-hard, provides a partial explanation. To overcome this complexity barrier, we identify a general class of transition-independent decentralized MDPs that is widely applicable. The class consists of independent collaborating agents that are tied up by a global reward function that depends on both of their histories. We present a novel algorithm for solving this class of problems and examine its properties. The result is the first effective technique to solve optimally a class of decentralized MDPs. This lays the foundation for further work in this area on both exact and approximate solutions.

  13. A Latent Transition Model with Logistic Regression

    ERIC Educational Resources Information Center

    Chung, Hwan; Walls, Theodore A.; Park, Yousung

    2007-01-01

    Latent transition models increasingly include covariates that predict prevalence of latent classes at a given time or transition rates among classes over time. In many situations, the covariate of interest may be latent. This paper describes an approach for handling both manifest and latent covariates in a latent transition model. A Bayesian…

  14. The Biological Big Bang model for the major transitions in evolution

    PubMed Central

    Koonin, Eugene V

    2007-01-01

    Background Major transitions in biological evolution show the same pattern of sudden emergence of diverse forms at a new level of complexity. The relationships between major groups within an emergent new class of biological entities are hard to decipher and do not seem to fit the tree pattern that, following Darwin's original proposal, remains the dominant description of biological evolution. The cases in point include the origin of complex RNA molecules and protein folds; major groups of viruses; archaea and bacteria, and the principal lineages within each of these prokaryotic domains; eukaryotic supergroups; and animal phyla. In each of these pivotal nexuses in life's history, the principal "types" seem to appear rapidly and fully equipped with the signature features of the respective new level of biological organization. No intermediate "grades" or intermediate forms between different types are detectable. Usually, this pattern is attributed to cladogenesis compressed in time, combined with the inevitable erosion of the phylogenetic signal. Hypothesis I propose that most or all major evolutionary transitions that show the "explosive" pattern of emergence of new types of biological entities correspond to a boundary between two qualitatively distinct evolutionary phases. The first, inflationary phase is characterized by extremely rapid evolution driven by various processes of genetic information exchange, such as horizontal gene transfer, recombination, fusion, fission, and spread of mobile elements. These processes give rise to a vast diversity of forms from which the main classes of entities at the new level of complexity emerge independently, through a sampling process. In the second phase, evolution dramatically slows down, the respective process of genetic information exchange tapers off, and multiple lineages of the new type of entities emerge, each of them evolving in a tree-like fashion from that point on. This biphasic model of evolution incorporates the

  15. Epithelial-mesenchymal transition in colonies of rhesus monkey embryonic stem cells: a model for processes involved in gastrulation.

    PubMed

    Behr, Rüdiger; Heneweer, Carola; Viebahn, Christoph; Denker, Hans-Werner; Thie, Michael

    2005-01-01

    Rhesus monkey embryonic stem (rhES) cells were grown on mouse embryonic fibroblast (MEF) feeder layers for up to 10 days to form multilayered colonies. Within this period, stem cell colonies differentiated transiently into complex structures with a disc-like morphology. These complex colonies were characterized by morphology, immunohistochemistry, and marker mRNA expression to identify processes of epithelialization as well as epithelial-mesenchymal transition (EMT) and pattern formation. Typically, differentiated colonies were comprised of an upper and a lower ES cell layer, the former growing on top of the layer of MEF cells whereas the lower ES cell layer spread out underneath the MEF cells. Interestingly, in the central part of the colonies, a roundish pit developed. Here the feeder layer disappeared, and upper layer cells seemed to ingress and migrate through the pit downward to form the lower layer while undergoing a transition from the epithelial to the mesenchymal phenotype, which was indicated by the loss of the marker proteins E-cadherin and ZO-1 in the lower layer. In support of this, we found a concomitant 10-fold upregulation of the gene Snail2, which is a key regulator of the EMT process. Conversion of epiblast to mesoderm was also indicated by the regulated expression of the mesoderm marker Brachyury. An EMT is a characteristic process of vertebrate gastrulation. Thus, these rhES cell colonies may be an interesting model for studies on some basic processes involved in early primate embryogenesis and may open new ways to study the regulation of EMT in vitro.

  16. A Conceptual Model for Leadership Transition

    ERIC Educational Resources Information Center

    Manderscheid, Steven V.; Ardichvili, Alexandre

    2008-01-01

    The purpose of this study was to develop a model of leadership transition based on an integrative review of literature. The article establishes a compelling case for focusing on leadership transitions as an area for study and leadership development practitioner intervention. The proposed model in this study identifies important success factors…

  17. Quantitative modeling of soil genesis processes

    NASA Technical Reports Server (NTRS)

    Levine, E. R.; Knox, R. G.; Kerber, A. G.

    1992-01-01

    For fine spatial scale simulation, a model is being developed to predict changes in properties over short-, meso-, and long-term time scales within horizons of a given soil profile. Processes that control these changes can be grouped into five major process clusters: (1) abiotic chemical reactions; (2) activities of organisms; (3) energy balance and water phase transitions; (4) hydrologic flows; and (5) particle redistribution. Landscape modeling of soil development is possible using digitized soil maps associated with quantitative soil attribute data in a geographic information system (GIS) framework to which simulation models are applied.

  18. Safety models incorporating graph theory based transit indicators.

    PubMed

    Quintero, Liliana; Sayed, Tarek; Wahba, Mohamed M

    2013-01-01

    There is a considerable need for tools to enable the evaluation of the safety of transit networks at the planning stage. One interesting approach for the planning of public transportation systems is the study of networks. Network techniques involve the analysis of systems by viewing them as a graph composed of a set of vertices (nodes) and edges (links). Once the transport system is visualized as a graph, various network properties can be evaluated based on the relationships between the network elements. Several indicators can be calculated including connectivity, coverage, directness and complexity, among others. The main objective of this study is to investigate the relationship between network-based transit indicators and safety. The study develops macro-level collision prediction models that explicitly incorporate transit physical and operational elements and transit network indicators as explanatory variables. Several macro-level (zonal) collision prediction models were developed using a generalized linear regression technique, assuming a negative binomial error structure. The models were grouped into four main themes: transit infrastructure, transit network topology, transit route design, and transit performance and operations. The safety models showed that collisions were significantly associated with transit network properties such as: connectivity, coverage, overlapping degree and the Local Index of Transit Availability. As well, the models showed a significant relationship between collisions and some transit physical and operational attributes such as the number of routes, frequency of routes, bus density, length of bus and 3+ priority lanes. Copyright © 2012 Elsevier Ltd. All rights reserved.

  19. Prediction of hemoglobin in blood donors using a latent class mixed-effects transition model.

    PubMed

    Nasserinejad, Kazem; van Rosmalen, Joost; de Kort, Wim; Rizopoulos, Dimitris; Lesaffre, Emmanuel

    2016-02-20

    Blood donors experience a temporary reduction in their hemoglobin (Hb) value after donation. At each visit, the Hb value is measured, and a too low Hb value leads to a deferral for donation. Because of the recovery process after each donation as well as state dependence and unobserved heterogeneity, longitudinal data of Hb values of blood donors provide unique statistical challenges. To estimate the shape and duration of the recovery process and to predict future Hb values, we employed three models for the Hb value: (i) a mixed-effects models; (ii) a latent-class mixed-effects model; and (iii) a latent-class mixed-effects transition model. In each model, a flexible function was used to model the recovery process after donation. The latent classes identify groups of donors with fast or slow recovery times and donors whose recovery time increases with the number of donations. The transition effect accounts for possible state dependence in the observed data. All models were estimated in a Bayesian way, using data of new entrant donors from the Donor InSight study. Informative priors were used for parameters of the recovery process that were not identified using the observed data, based on results from the clinical literature. The results show that the latent-class mixed-effects transition model fits the data best, which illustrates the importance of modeling state dependence, unobserved heterogeneity, and the recovery process after donation. The estimated recovery time is much longer than the current minimum interval between donations, suggesting that an increase of this interval may be warranted. Copyright © 2015 John Wiley & Sons, Ltd.

  20. Implicit Value Updating Explains Transitive Inference Performance: The Betasort Model

    PubMed Central

    Jensen, Greg; Muñoz, Fabian; Alkan, Yelda; Ferrera, Vincent P.; Terrace, Herbert S.

    2015-01-01

    Transitive inference (the ability to infer that B > D given that B > C and C > D) is a widespread characteristic of serial learning, observed in dozens of species. Despite these robust behavioral effects, reinforcement learning models reliant on reward prediction error or associative strength routinely fail to perform these inferences. We propose an algorithm called betasort, inspired by cognitive processes, which performs transitive inference at low computational cost. This is accomplished by (1) representing stimulus positions along a unit span using beta distributions, (2) treating positive and negative feedback asymmetrically, and (3) updating the position of every stimulus during every trial, whether that stimulus was visible or not. Performance was compared for rhesus macaques, humans, and the betasort algorithm, as well as Q-learning, an established reward-prediction error (RPE) model. Of these, only Q-learning failed to respond above chance during critical test trials. Betasort’s success (when compared to RPE models) and its computational efficiency (when compared to full Markov decision process implementations) suggests that the study of reinforcement learning in organisms will be best served by a feature-driven approach to comparing formal models. PMID:26407227

  1. Implicit Value Updating Explains Transitive Inference Performance: The Betasort Model.

    PubMed

    Jensen, Greg; Muñoz, Fabian; Alkan, Yelda; Ferrera, Vincent P; Terrace, Herbert S

    2015-01-01

    Transitive inference (the ability to infer that B > D given that B > C and C > D) is a widespread characteristic of serial learning, observed in dozens of species. Despite these robust behavioral effects, reinforcement learning models reliant on reward prediction error or associative strength routinely fail to perform these inferences. We propose an algorithm called betasort, inspired by cognitive processes, which performs transitive inference at low computational cost. This is accomplished by (1) representing stimulus positions along a unit span using beta distributions, (2) treating positive and negative feedback asymmetrically, and (3) updating the position of every stimulus during every trial, whether that stimulus was visible or not. Performance was compared for rhesus macaques, humans, and the betasort algorithm, as well as Q-learning, an established reward-prediction error (RPE) model. Of these, only Q-learning failed to respond above chance during critical test trials. Betasort's success (when compared to RPE models) and its computational efficiency (when compared to full Markov decision process implementations) suggests that the study of reinforcement learning in organisms will be best served by a feature-driven approach to comparing formal models.

  2. A Spalart-Allmaras local correlation-based transition model for Thermo-fuid dynamics

    NASA Astrophysics Data System (ADS)

    D'Alessandro, V.; Garbuglia, F.; Montelpare, S.; Zoppi, A.

    2017-11-01

    The study of innovative energy systems often involves complex fluid flows problems and the Computational Fluid-Dynamics (CFD) is one of the main tools of analysis. It is important to put in evidence that in several energy systems the flow field experiences the laminar-to-turbulent transition. Direct Numerical Simulations (DNS) or Large Eddy Simulation (LES) are able to predict the flow transition but they are still inapplicable to the study of real problems due to the significant computational resources requirements. Differently standard Reynolds Averaged Navier Stokes (RANS) approaches are not always reliable since they assume a fully turbulent regime. In order to overcome this drawback in the recent years some locally formulated transition RANS models have been developed. In this work, we present a local correlation-based transition approach adding two equations that control the laminar-toturbulent transition process -γ and \\[\\overset{}{\\mathop{{{\\operatorname{Re}}θ, \\text{t}}}} \\] - to the well-known Spalart-Allmaras (SA) turbulence model. The new model was implemented within OpenFOAM code. The energy equation is also implemented in order to evaluate the model performance in thermal-fluid dynamics applications. In all the considered cases a very good agreement between numerical and experimental data was observed.

  3. Absorbing phase transitions in deterministic fixed-energy sandpile models

    NASA Astrophysics Data System (ADS)

    Park, Su-Chan

    2018-03-01

    We investigate the origin of the difference, which was noticed by Fey et al. [Phys. Rev. Lett. 104, 145703 (2010), 10.1103/PhysRevLett.104.145703], between the steady state density of an Abelian sandpile model (ASM) and the transition point of its corresponding deterministic fixed-energy sandpile model (DFES). Being deterministic, the configuration space of a DFES can be divided into two disjoint classes such that every configuration in one class should evolve into one of absorbing states, whereas no configurations in the other class can reach an absorbing state. Since the two classes are separated in terms of toppling dynamics, the system can be made to exhibit an absorbing phase transition (APT) at various points that depend on the initial probability distribution of the configurations. Furthermore, we show that in general the transition point also depends on whether an infinite-size limit is taken before or after the infinite-time limit. To demonstrate, we numerically study the two-dimensional DFES with Bak-Tang-Wiesenfeld toppling rule (BTW-FES). We confirm that there are indeed many thresholds. Nonetheless, the critical phenomena at various transition points are found to be universal. We furthermore discuss a microscopic absorbing phase transition, or a so-called spreading dynamics, of the BTW-FES, to find that the phase transition in this setting is related to the dynamical isotropic percolation process rather than self-organized criticality. In particular, we argue that choosing recurrent configurations of the corresponding ASM as an initial configuration does not allow for a nontrivial APT in the DFES.

  4. Absorbing phase transitions in deterministic fixed-energy sandpile models.

    PubMed

    Park, Su-Chan

    2018-03-01

    We investigate the origin of the difference, which was noticed by Fey et al. [Phys. Rev. Lett. 104, 145703 (2010)PRLTAO0031-900710.1103/PhysRevLett.104.145703], between the steady state density of an Abelian sandpile model (ASM) and the transition point of its corresponding deterministic fixed-energy sandpile model (DFES). Being deterministic, the configuration space of a DFES can be divided into two disjoint classes such that every configuration in one class should evolve into one of absorbing states, whereas no configurations in the other class can reach an absorbing state. Since the two classes are separated in terms of toppling dynamics, the system can be made to exhibit an absorbing phase transition (APT) at various points that depend on the initial probability distribution of the configurations. Furthermore, we show that in general the transition point also depends on whether an infinite-size limit is taken before or after the infinite-time limit. To demonstrate, we numerically study the two-dimensional DFES with Bak-Tang-Wiesenfeld toppling rule (BTW-FES). We confirm that there are indeed many thresholds. Nonetheless, the critical phenomena at various transition points are found to be universal. We furthermore discuss a microscopic absorbing phase transition, or a so-called spreading dynamics, of the BTW-FES, to find that the phase transition in this setting is related to the dynamical isotropic percolation process rather than self-organized criticality. In particular, we argue that choosing recurrent configurations of the corresponding ASM as an initial configuration does not allow for a nontrivial APT in the DFES.

  5. Methodology Development of a Gas-Liquid Dynamic Flow Regime Transition Model

    NASA Astrophysics Data System (ADS)

    Doup, Benjamin Casey

    Current reactor safety analysis codes, such as RELAP5, TRACE, and CATHARE, use flow regime maps or flow regime transition criteria that were developed for static fully-developed two-phase flows to choose interfacial transfer models that are necessary to solve the two-fluid model. The flow regime is therefore difficult to identify near the flow regime transitions, in developing two-phase flows, and in transient two-phase flows. Interfacial area transport equations were developed to more accurately predict the dynamic nature of two-phase flows. However, other model coefficients are still flow regime dependent. Therefore, an accurate prediction of the flow regime is still important. In the current work, the methodology for the development of a dynamic flow regime transition model that uses the void fraction and interfacial area concentration obtained by solving three-field the two-fluid model and two-group interfacial area transport equation is investigated. To develop this model, detailed local experimental data are obtained, the two-group interfacial area transport equations are revised, and a dynamic flow regime transition model is evaluated using a computational fluid dynamics model. Local experimental data is acquired for 63 different flow conditions in bubbly, cap-bubbly, slug, and churn-turbulent flow regimes. The measured parameters are the group-1 and group-2 bubble number frequency, void fraction, interfacial area concentration, and interfacial bubble velocities. The measurements are benchmarked by comparing the prediction of the superficial gas velocities, determined using the local measurements with those determined from volumetric flow rate measurements and the agreement is generally within +/-20%. The repeatability four-sensor probe construction process is within +/-10%. The repeatability of the measurement process is within +/-7%. The symmetry of the test section is examined and the average agreement is within +/-5.3% at z/D = 10 and +/-3.4% at z/D = 32

  6. Physical, Cognitive, and Psychosocial Variables from the Disablement Process Model Predict Patterns of Independence and the Transition into Disability for the Oldest-Old

    ERIC Educational Resources Information Center

    Fauth, Elizabeth Braungart; Zarit, Steven H.; Malmberg, Bo; Johansson, Boo

    2007-01-01

    Purpose: This study used the Disablement Process Model to predict whether a sample of the oldest-old maintained their disability or disability-free status over a 2- and 4-year follow-up, or whether they transitioned into a state of disability during this time. Design and Methods: We followed a sample of 149 Swedish adults who were 86 years of age…

  7. A constructivist connectionist model of transitions on false-belief tasks.

    PubMed

    Berthiaume, Vincent G; Shultz, Thomas R; Onishi, Kristine H

    2013-03-01

    How do children come to understand that others have mental representations, e.g., of an object's location? Preschoolers go through two transitions on verbal false-belief tasks, in which they have to predict where an agent will search for an object that was moved in her absence. First, while three-and-a-half-year-olds usually fail at approach tasks, in which the agent wants to find the object, children just under four succeed. Second, only after four do children succeed at tasks in which the agent wants to avoid the object. We present a constructivist connectionist model that autonomously reproduces the two transitions and suggests that the transitions are due to increases in general processing abilities enabling children to (1) overcome a default true-belief attribution by distinguishing false- from true-belief situations, and to (2) predict search in avoidance situations, where there is often more than one correct, empty search location. Constructivist connectionist models are rigorous, flexible and powerful tools that can be analyzed before and after transitions to uncover novel and emergent mechanisms of cognitive development. Copyright © 2012 Elsevier B.V. All rights reserved.

  8. Dynamo transition in low-dimensional models.

    PubMed

    Verma, Mahendra K; Lessinnes, Thomas; Carati, Daniele; Sarris, Ioannis; Kumar, Krishna; Singh, Meenakshi

    2008-09-01

    Two low-dimensional magnetohydrodynamic models containing three velocity and three magnetic modes are described. One of them (nonhelical model) has zero kinetic and current helicity, while the other model (helical) has nonzero kinetic and current helicity. The velocity modes are forced in both these models. These low-dimensional models exhibit a dynamo transition at a critical forcing amplitude that depends on the Prandtl number. In the nonhelical model, dynamo exists only for magnetic Prandtl number beyond 1, while the helical model exhibits dynamo for all magnetic Prandtl number. Although the model is far from reproducing all the possible features of dynamo mechanisms, its simplicity allows a very detailed study and the observed dynamo transition is shown to bear similarities with recent numerical and experimental results.

  9. A stochastic estimation procedure for intermittently-observed semi-Markov multistate models with back transitions.

    PubMed

    Aralis, Hilary; Brookmeyer, Ron

    2017-01-01

    Multistate models provide an important method for analyzing a wide range of life history processes including disease progression and patient recovery following medical intervention. Panel data consisting of the states occupied by an individual at a series of discrete time points are often used to estimate transition intensities of the underlying continuous-time process. When transition intensities depend on the time elapsed in the current state and back transitions between states are possible, this intermittent observation process presents difficulties in estimation due to intractability of the likelihood function. In this manuscript, we present an iterative stochastic expectation-maximization algorithm that relies on a simulation-based approximation to the likelihood function and implement this algorithm using rejection sampling. In a simulation study, we demonstrate the feasibility and performance of the proposed procedure. We then demonstrate application of the algorithm to a study of dementia, the Nun Study, consisting of intermittently-observed elderly subjects in one of four possible states corresponding to intact cognition, impaired cognition, dementia, and death. We show that the proposed stochastic expectation-maximization algorithm substantially reduces bias in model parameter estimates compared to an alternative approach used in the literature, minimal path estimation. We conclude that in estimating intermittently observed semi-Markov models, the proposed approach is a computationally feasible and accurate estimation procedure that leads to substantial improvements in back transition estimates.

  10. Closure models for transitional blunt-body flows

    NASA Astrophysics Data System (ADS)

    Nance, Robert Paul

    1998-12-01

    A mean-flow modeling approach is proposed for the prediction of high-speed blunt-body wake flows undergoing transition to turbulence. This method couples the k- /zeta (Enstrophy) compressible turbulence model with a procedure for characterizing non-turbulent fluctuations upstream of transition. Two different instability mechanisms are examined in this study. In the first model, transition is brought about by streamwise disturbance modes, whereas the second mechanism considers instabilities in the free shear layer associated with the wake flow. An important feature of this combined approach is the ability to specify or predict the location of transition onset. Solutions obtained using the new approach are presented for a variety of perfect-gas hypersonic flows over blunt- cone configurations. These results are shown to provide better agreement with experimental heating data than earlier laminar predictions by other researchers. In addition, it is demonstrated that the free-shear-layer instability mechanism is superior to the streamwise mechanism in terms of comparisons with heating measurements. The favorable comparisons are a strong indication that transition to turbulence is indeed present in the flowfields considered. They also show that the present method is a useful predictive tool for transitional blunt-body wake flows.

  11. The Transition Assessment Process and IDEIA 2004

    ERIC Educational Resources Information Center

    Sitlington, Patricia L.; Clark, Gary M.

    2007-01-01

    This article will first provide an overview of the transition assessment process in terms of the requirements of the Individuals with Disabilities Education Improvement Act of 2004 and the basic tenets of the process. The second section will provide an overview of the methods of gathering assessment information on the student and on the living,…

  12. Numerical simulation of transitional flow on a wind turbine airfoil with RANS-based transition model

    NASA Astrophysics Data System (ADS)

    Zhang, Ye; Sun, Zhengzhong; van Zuijlen, Alexander; van Bussel, Gerard

    2017-09-01

    This paper presents a numerical investigation of transitional flow on the wind turbine airfoil DU91-W2-250 with chord-based Reynolds number Rec = 1.0 × 106. The Reynolds-averaged Navier-Stokes based transition model using laminar kinetic energy concept, namely the k - kL - ω model, is employed to resolve the boundary layer transition. Some ambiguities for this model are discussed and it is further implemented into OpenFOAM-2.1.1. The k - kL - ω model is first validated through the chosen wind turbine airfoil at the angle of attack (AoA) of 6.24° against wind tunnel measurement, where lift and drag coefficients, surface pressure distribution and transition location are compared. In order to reveal the transitional flow on the airfoil, the mean boundary layer profiles in three zones, namely the laminar, transitional and fully turbulent regimes, are investigated. Observation of flow at the transition location identifies the laminar separation bubble. The AoA effect on boundary layer transition over wind turbine airfoil is also studied. Increasing the AoA from -3° to 10°, the laminar separation bubble moves upstream and reduces in size, which is in close agreement with wind tunnel measurement.

  13. Path-preference cellular-automaton model for traffic flow through transit points and its application to the transcription process in human cells.

    PubMed

    Ohta, Yoshihiro; Nishiyama, Akinobu; Wada, Yoichiro; Ruan, Yijun; Kodama, Tatsuhiko; Tsuboi, Takashi; Tokihiro, Tetsuji; Ihara, Sigeo

    2012-08-01

    We all use path routing everyday as we take shortcuts to avoid traffic jams, or by using faster traffic means. Previous models of traffic flow of RNA polymerase II (RNAPII) during transcription, however, were restricted to one dimension along the DNA template. Here we report the modeling and application of traffic flow in transcription that allows preferential paths of different dimensions only restricted to visit some transit points, as previously introduced between the 5' and 3' end of the gene. According to its position, an RNAPII protein molecule prefers paths obeying two types of time-evolution rules. One is an asymmetric simple exclusion process (ASEP) along DNA, and the other is a three-dimensional jump between transit points in DNA where RNAPIIs are staying. Simulations based on our model, and comparison experimental results, reveal how RNAPII molecules are distributed at the DNA-loop-formation-related protein binding sites as well as CTCF insulator proteins (or exons). As time passes after the stimulation, the RNAPII density at these sites becomes higher. Apparent far-distance jumps in one dimension are realized by short-range three-dimensional jumps between DNA loops. We confirm the above conjecture by applying our model calculation to the SAMD4A gene by comparing the experimental results. Our probabilistic model provides possible scenarios for assembling RNAPII molecules into transcription factories, where RNAPII and related proteins cooperatively transcribe DNA.

  14. Transition and Turbulence Modeling for Blunt-Body Wake Flows

    NASA Technical Reports Server (NTRS)

    Nance, Robert P.; Horvath, Thomas J.; Hassan, H. A.

    1997-01-01

    This study attempts t o improve the modeling and computational prediction of high- speed transitional wake flows. The recently developed kappa - zeta (Enstrophy) turbulence model is coupled with a newly developed transition prediction method and implemented in an implicit flow solver well-suited to hypersonic flows. In this model, transition onset is determined as part of the solution. Results obtained using the new model for a 70- deg blunted cone/sting geometry demonstrate better agreement with experimental heat- transfer measurements when compared to laminar calculations as well as solutions using the kappa - omega model. Results are also presented for the situation where transition onset is preselected. It is shown that, in this case, results are quite sensitive to location of the transition point.

  15. Transition from a planar interface to cellular and dendritic structures during rapid solidification processing

    NASA Technical Reports Server (NTRS)

    Laxmanan, V.

    1986-01-01

    The development of theoretical models which characterize the planar-cellular and cell-dendrite transitions is described. The transitions are analyzed in terms of the Chalmers number, the solute Peclet number, and the tip stability parameter, which correlate microstructural features and processing conditions. The planar-cellular transition is examined using the constitutional supercooling theory of Chalmers et al., (1953) and it is observed that the Chalmers number is between 0 and 1 during dendritic and cellular growth. Analysis of cell-dendrite transition data reveal that the transition occurs when the solute Peclet number goes through a minimum, the primary arm spacings go through a maximum, and the Chalmers number is equal to 1/2. The relation between the tip stability parameter and the solute Peclet number is investigated and it is noted that the tip stability parameter is useful for studying dendritic growth in alloys.

  16. UTM: Universal Transit Modeller

    NASA Astrophysics Data System (ADS)

    Deeg, Hans J.

    2014-12-01

    The Universal Transit Modeller (UTM) is a light-curve simulator for all kinds of transiting or eclipsing configurations between arbitrary numbers of several types of objects, which may be stars, planets, planetary moons, and planetary rings. A separate fitting program, UFIT (Universal Fitter) is part of the UTM distribution and may be used to derive best fits to light-curves for any set of continuously variable parameters. UTM/UFIT is written in IDL code and its source is released in the public domain under the GNU General Public License.

  17. Cell transmission model of dynamic assignment for urban rail transit networks.

    PubMed

    Xu, Guangming; Zhao, Shuo; Shi, Feng; Zhang, Feilian

    2017-01-01

    For urban rail transit network, the space-time flow distribution can play an important role in evaluating and optimizing the space-time resource allocation. For obtaining the space-time flow distribution without the restriction of schedules, a dynamic assignment problem is proposed based on the concept of continuous transmission. To solve the dynamic assignment problem, the cell transmission model is built for urban rail transit networks. The priority principle, queuing process, capacity constraints and congestion effects are considered in the cell transmission mechanism. Then an efficient method is designed to solve the shortest path for an urban rail network, which decreases the computing cost for solving the cell transmission model. The instantaneous dynamic user optimal state can be reached with the method of successive average. Many evaluation indexes of passenger flow can be generated, to provide effective support for the optimization of train schedules and the capacity evaluation for urban rail transit network. Finally, the model and its potential application are demonstrated via two numerical experiments using a small-scale network and the Beijing Metro network.

  18. Development of one-equation transition/turbulence models

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Edwards, J.R.; Roy, C.J.; Blottner, F.G.

    2000-01-14

    This paper reports on the development of a unified one-equation model for the prediction of transitional and turbulent flows. An eddy viscosity--transport equation for nonturbulent fluctuation growth based on that proposed by Warren and Hassan is combined with the Spalart-Allmaras one-equation model for turbulent fluctuation growth. Blending of the two equations is accomplished through a multidimensional intermittency function based on the work of Dhawan and Narasimha. The model predicts both the onset and extent of transition. Low-speed test cases include transitional flow over a flat plate, a single element airfoil, and a multi-element airfoil in landing configuration. High-speed test casesmore » include transitional Mach 3.5 flow over a 5{degree} cone and Mach 6 flow over a flared-cone configuration. Results are compared with experimental data, and the grid-dependence of selected predictions is analyzed.« less

  19. Sabin-to-Mahoney Transition Model of Quasispecies Replication

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    2009-05-31

    Qspp is an agent-based stochastic simulation model of the Poliovirus Sabin-to-Mahoney transition. This code simulates a cell-to-cell model of Poliovirus replication. The model tracks genotypes (virus genomes) as they are replicated in cells, and as the cells burst and release particles into the medium of a culture dish. An inoculum is then taken from the pool of virions and is used to inoculate cells on a new dish. This process repeats. The Sabin genotype comprises the initial inoculum. Nucleotide positions that match the Sabin1 (vaccine strain) and Mahoney (wild type) genotypes, as well as the neurovirulent phenotype (from the literature)more » are enumerated as constants.« less

  20. Cost Models for MMC Manufacturing Processes

    NASA Technical Reports Server (NTRS)

    Elzey, Dana M.; Wadley, Haydn N. G.

    1996-01-01

    Processes for the manufacture of advanced metal matrix composites are rapidly approaching maturity in the research laboratory and there is growing interest in their transition to industrial production. However, research conducted to date has almost exclusively focused on overcoming the technical barriers to producing high-quality material and little attention has been given to the economical feasibility of these laboratory approaches and process cost issues. A quantitative cost modeling (QCM) approach was developed to address these issues. QCM are cost analysis tools based on predictive process models relating process conditions to the attributes of the final product. An important attribute, of the QCM approach is the ability to predict the sensitivity of material production costs to product quality and to quantitatively explore trade-offs between cost and quality. Applications of the cost models allow more efficient direction of future MMC process technology development and a more accurate assessment of MMC market potential. Cost models were developed for two state-of-the art metal matrix composite (MMC) manufacturing processes: tape casting and plasma spray deposition. Quality and Cost models are presented for both processes and the resulting predicted quality-cost curves are presented and discussed.

  1. An intermittency model for predicting roughness induced transition

    NASA Astrophysics Data System (ADS)

    Ge, Xuan; Durbin, Paul

    2014-11-01

    An extended model for roughness-induced transition is proposed based on an intermittency transport equation for RANS modeling formulated in local variables. To predict roughness effects in the fully turbulent boundary layer, published boundary conditions for k and ω are used, which depend on the equivalent sand grain roughness height, and account for the effective displacement of wall distance origin. Similarly in our approach, wall distance in the transition model for smooth surfaces is modified by an effective origin, which depends on roughness. Flat plate test cases are computed to show that the proposed model is able to predict the transition onset in agreement with a data correlation of transition location versus roughness height, Reynolds number, and inlet turbulence intensity. Experimental data for a turbine cascade are compared with the predicted results to validate the applicability of the proposed model. Supported by NSF Award Number 1228195.

  2. Effects of ward rotation on subsequent transition processes of Japanese clinical nurses.

    PubMed

    Fujino, Mitsuku; Nojima, Yoshiko

    2005-03-01

    The purpose of this study was to examine the experience of Japanese clinical nurses undertaking a ward rotation in a general hospital, and its effects on subsequent processes relating to: (i) perception of ward rotation; (ii) reactions to the ward transition process; and (iii) outcomes of ward rotation. In-depth interviews were conducted with 21 Japanese clinical nurses who had an average of 8.8 years (SD = 5.50) clinical experience. Findings indicated that participants experienced role overload, role incongruity and/or role underload, role overqualification, or role ambiguity in the new environment. These role stresses created critical emotional distress during the transition process. The high desire for career development facilitated the transition process, while lack of preparation inhibited the transition process. To facilitate smooth transition, well-prepared and structured supports based on reliable interpersonal relationships are necessary. The findings offer significant cues for effective ward rotation programs. The implication for nursing administrators is that appropriate ward rotations enhance confidence and promote effective role development in the new clinical setting.

  3. Mathematics, Modelling and Students in Transition

    ERIC Educational Resources Information Center

    Wake, Geoff

    2016-01-01

    This article is based on data from two major research projects that investigated students involved in mathematically demanding courses during their transition through college and into university. It explores the nature of modelling as a mathematical practice in this important transition phase for students. Theoretical considerations are informed…

  4. A Model of Mental State Transition Network

    NASA Astrophysics Data System (ADS)

    Xiang, Hua; Jiang, Peilin; Xiao, Shuang; Ren, Fuji; Kuroiwa, Shingo

    Emotion is one of the most essential and basic attributes of human intelligence. Current AI (Artificial Intelligence) research is concentrating on physical components of emotion, rarely is it carried out from the view of psychology directly(1). Study on the model of artificial psychology is the first step in the development of human-computer interaction. As affective computing remains unpredictable, creating a reasonable mental model becomes the primary task for building a hybrid system. A pragmatic mental model is also the fundament of some key topics such as recognition and synthesis of emotions. In this paper a Mental State Transition Network Model(2) is proposed to detect human emotions. By a series of psychological experiments, we present a new way to predict coming human's emotions depending on the various current emotional states under various stimuli. Besides, people in different genders and characters are taken into consideration in our investigation. According to the psychological experiments data derived from 200 questionnaires, a Mental State Transition Network Model for describing the transitions in distribution among the emotions and relationships between internal mental situations and external are concluded. Further more the coefficients of the mental transition network model were achieved. Comparing seven relative evaluating experiments, an average precision rate of 0.843 is achieved using a set of samples for the proposed model.

  5. Adding structure to the transition process to advanced mathematical activity

    NASA Astrophysics Data System (ADS)

    Engelbrecht, Johann

    2010-03-01

    The transition process to advanced mathematical thinking is experienced as traumatic by many students. Experiences that students had of school mathematics differ greatly to what is expected from them at university. Success in school mathematics meant application of different methods to get an answer. Students are not familiar with logical deductive reasoning, required in advanced mathematics. It is necessary to assist students in this transition process, in moving from general to mathematical thinking. In this article some structure is suggested for this transition period. This essay is an argumentative exposition supported by personal experience and international literature. This makes this study theoretical rather than empirical.

  6. Transition Process of Procedural to Conceptual Understanding in Solving Mathematical Problems

    ERIC Educational Resources Information Center

    Fatqurhohman

    2016-01-01

    This article aims to describe the transition process from procedural understanding to conceptual understanding in solving mathematical problems. Subjects in this study were three students from 20 fifth grade students of SDN 01 Sumberberas Banyuwangi selected based on the results of the students' answers. The transition process from procedural to…

  7. Keys to Transition: The California Model.

    ERIC Educational Resources Information Center

    Kearly, Patt

    This publication addresses basic issues related to the concept of transition as it is applied to students with disabilities in California. Following a pretest (and its answer key), the document uses a question and answer format to discuss common concerns about transition, normalization, the school role, the "Bridges" model developed by…

  8. Ages and transit times as important diagnostics of model performance for predicting carbon dynamics in terrestrial vegetation models

    NASA Astrophysics Data System (ADS)

    Ceballos-Núñez, Verónika; Richardson, Andrew D.; Sierra, Carlos A.

    2018-03-01

    The global carbon cycle is strongly controlled by the source/sink strength of vegetation as well as the capacity of terrestrial ecosystems to retain this carbon. These dynamics, as well as processes such as the mixing of old and newly fixed carbon, have been studied using ecosystem models, but different assumptions regarding the carbon allocation strategies and other model structures may result in highly divergent model predictions. We assessed the influence of three different carbon allocation schemes on the C cycling in vegetation. First, we described each model with a set of ordinary differential equations. Second, we used published measurements of ecosystem C compartments from the Harvard Forest Environmental Measurement Site to find suitable parameters for the different model structures. And third, we calculated C stocks, release fluxes, radiocarbon values (based on the bomb spike), ages, and transit times. We obtained model simulations in accordance with the available data, but the time series of C in foliage and wood need to be complemented with other ecosystem compartments in order to reduce the high parameter collinearity that we observed, and reduce model equifinality. Although the simulated C stocks in ecosystem compartments were similar, the different model structures resulted in very different predictions of age and transit time distributions. In particular, the inclusion of two storage compartments resulted in the prediction of a system mean age that was 12-20 years older than in the models with one or no storage compartments. The age of carbon in the wood compartment of this model was also distributed towards older ages, whereas fast cycling compartments had an age distribution that did not exceed 5 years. As expected, models with C distributed towards older ages also had longer transit times. These results suggest that ages and transit times, which can be indirectly measured using isotope tracers, serve as important diagnostics of model structure

  9. Chapter 5: Application of state-and-transition models to evaluate wildlife habitat

    Treesearch

    Anita T. Morzillo; Pamela Comeleo; Blair Csuti; Stephanie Lee

    2014-01-01

    Wildlife habitat analysis often is a central focus of natural resources management and policy. State-and-transition models (STMs) allow for simulation of landscape level ecological processes, and for managers to test “what if” scenarios of how those processes may affect wildlife habitat. This chapter describes the methods used to link STM output to wildlife habitat to...

  10. Development of state and transition model assumptions used in National Forest Plan revision

    Treesearch

    Eric B. Henderson

    2008-01-01

    State and transition models are being utilized in forest management analysis processes to evaluate assumptions about disturbances and succession. These models assume valid information about seral class successional pathways and timing. The Forest Vegetation Simulator (FVS) was used to evaluate seral class succession assumptions for the Hiawatha National Forest in...

  11. Experience Transitioning Models and Data at the NOAA Space Weather Prediction Center

    NASA Astrophysics Data System (ADS)

    Berger, Thomas

    2016-07-01

    The NOAA Space Weather Prediction Center has a long history of transitioning research data and models into operations and with the validation activities required. The first stage in this process involves demonstrating that the capability has sufficient value to customers to justify the cost needed to transition it and to run it continuously and reliably in operations. Once the overall value is demonstrated, a substantial effort is then required to develop the operational software from the research codes. The next stage is to implement and test the software and product generation on the operational computers. Finally, effort must be devoted to establishing long-term measures of performance, maintaining the software, and working with forecasters, customers, and researchers to improve over time the operational capabilities. This multi-stage process of identifying, transitioning, and improving operational space weather capabilities will be discussed using recent examples. Plans for future activities will also be described.

  12. Magnetization processes and existence of reentrant phase transitions in coupled spin-electron model on doubly decorated planar lattices

    NASA Astrophysics Data System (ADS)

    Čenčariková, Hana; Strečka, Jozef; Gendiar, Andrej

    2018-04-01

    An alternative model for a description of magnetization processes in coupled 2D spin-electron systems has been introduced and rigorously examined using the generalized decoration-iteration transformation and the corner transfer matrix renormalization group method. The model consists of localized Ising spins placed on nodal lattice sites and mobile electrons delocalized over the pairs of decorating sites. It takes into account a hopping term for mobile electrons, the Ising coupling between mobile electrons and localized spins as well as the Zeeman term acting on both types of particles. The ground-state and finite-temperature phase diagrams were established and comprehensively analyzed. It was found that the ground-state phase diagrams are very rich depending on the electron hopping and applied magnetic field. The diversity of magnetization curves can be related to intermediate magnetization plateaus, which may be continuously tuned through the density of mobile electrons. In addition, the existence of several types of reentrant phase transitions driven either by temperature or magnetic field was proven.

  13. Using the Research and Development in Organisations Model to Improve Transition to High School

    ERIC Educational Resources Information Center

    Ashton, Rebecca

    2009-01-01

    This article describes the application of the Research and Development in Organisations (RADIO) model to five action research projects carried out in schools around transition processes. The RADIO model is mapped onto all five studies, and adapting the model in order to include greater stakeholder participation is suggested. Reflections are made…

  14. Modeling of turbulence and transition

    NASA Technical Reports Server (NTRS)

    Shih, Tsan-Hsing

    1992-01-01

    The first objective is to evaluate current two-equation and second order closure turbulence models using available direct numerical simulations and experiments, and to identify the models which represent the state of the art in turbulence modeling. The second objective is to study the near-wall behavior of turbulence, and to develop reliable models for an engineering calculation of turbulence and transition. The third objective is to develop a two-scale model for compressible turbulence.

  15. Modeling and Simulation of Quenching and Tempering Process in steels

    NASA Astrophysics Data System (ADS)

    Deng, Xiaohu; Ju, Dongying

    Quenching and tempering (Q&T) is a combined heat treatment process to achieve maximum toughness and ductility at a specified hardness and strength. It is important to develop a mathematical model for quenching and tempering process for satisfy requirement of mechanical properties with low cost. This paper presents a modified model to predict structural evolution and hardness distribution during quenching and tempering process of steels. The model takes into account tempering parameters, carbon content, isothermal and non-isothermal transformations. Moreover, precipitation of transition carbides, decomposition of retained austenite and precipitation of cementite can be simulated respectively. Hardness distributions of quenched and tempered workpiece are predicted by experimental regression equation. In order to validate the model, it is employed to predict the tempering of 80MnCr5 steel. The predicted precipitation dynamics of transition carbides and cementite is consistent with the previous experimental and simulated results from literature. Then the model is implemented within the framework of the developed simulation code COSMAP to simulate microstructure, stress and distortion in the heat treated component. It is applied to simulate Q&T process of J55 steel. The calculated results show a good agreement with the experimental ones. This agreement indicates that the model is effective for simulation of Q&T process of steels.

  16. Introduction to symposium on unmeasured heterogeneity in school transition models.

    PubMed

    Mare, Robert D

    2011-09-01

    Researchers have used models of school transitions for over 30 years to describe inequality of educational opportunity and have contributed a number of important refinements and extensions. School transition models have the complication that the estimated effects of family background on the probability of continuing in school are affected by differential attrition on unobserved factors at earlier stages of schooling. The articles in this symposium present a variety of useful approaches to unobserved heterogeneity in school transition models. Investigators who use these approaches should attend to several issues: (1) models for school transitions may be used both descriptively (and are not therefore subject to any well-defined "bias") and as tools for causal inference. (2) The concept of bias presupposes an underlying experiment, structural model, or population model that would, in principle, define the corresponding unbiased parameters - yet these underlying models are difficult to specify for school transition models. (3) Unobserved determinants of whether individuals make school transitions may be both exogenous and endogenous with respect to the observed regressors in the model. Without a model of how unobserved heterogeneity arises, attempted "corrections" for unmeasured heterogeneity may yield misleading estimates of the effects of measured determinants of school continuation.

  17. Ages and transit times as important diagnostics of model performance for predicting C allocation in ecosystem models

    NASA Astrophysics Data System (ADS)

    Ceballos-Núñez, Verónika; Richardson, Andrew; Sierra, Carlos

    2017-04-01

    was 50 years faster than for the model without storage. These results suggest that ages and transit times, which can be indirectly measured using isotope tracers, serve as important diagnostics of model structure and could largely help to reduce uncertainties in model predictions. Furthermore, by considering age and transit times of C in vegetation compartments as distributions, not only their mean values, we obtain additional insights on the temporal dynamics of carbon use, storage, and allocation to plant parts, which not only depends on the rate at which this C is transferred in and out of the compartments, but also on the stochastic nature of the process itself.

  18. Transition Heat Transfer Modeling Based on the Characteristics of Turbulent Spots

    NASA Technical Reports Server (NTRS)

    Simon, Fred; Boyle, Robert

    1998-01-01

    While turbulence models are being developed which show promise for simulating the transition region on a turbine blade or vane, it is believed that the best approach with the greatest potential for practical use is the use of models which incorporate the physics of turbulent spots present in the transition region. This type of modeling results in the prediction of transition region intermittency which when incorporated in turbulence models give a good to excellent prediction of the transition region heat transfer. Some models are presented which show how turbulent spot characteristics and behavior can be employed to predict the effect of pressure gradient and Mach number on the transition region. The models predict the spot formation rate which is needed, in addition to the transition onset location, in the Narasimha concentrated breakdown intermittency equation. A simplified approach is taken for modeling turbulent spot growth and interaction in the transition region which utilizes the turbulent spot variables governing transition length and spot generation rate. The models are expressed in terms of spot spreading angle, dimensionless spot velocity, dimensionless spot area, disturbance frequency and Mach number. The models are used in conjunction with a computer code to predict the effects of pressure gradient and Mach number on the transition region and compared with VKI experimental turbine data.

  19. Real-time monitoring of clinical processes using complex event processing and transition systems.

    PubMed

    Meinecke, Sebastian

    2014-01-01

    Dependencies between tasks in clinical processes are often complex and error-prone. Our aim is to describe a new approach for the automatic derivation of clinical events identified via the behaviour of IT systems using Complex Event Processing. Furthermore we map these events on transition systems to monitor crucial clinical processes in real-time for preventing and detecting erroneous situations.

  20. Use of the forest vegetation simulator to quantify disturbance activities in state and transition models

    Treesearch

    Reuben Weisz; Don Vandendriesche

    2012-01-01

    The Forest Vegetation Simulator (FVS) has been used to provide rates of natural growth transitions under endemic conditions for use in State and Transition Models (STMs). This process has previously been presented. This paper expands on that work by citing the methods used to capture resultant vegetation states following disturbance activities; be it of natural causes...

  1. Two kinds of phase transitions in a voting model

    NASA Astrophysics Data System (ADS)

    Hisakado, M.; Mori, S.

    2012-08-01

    In this paper, we discuss a voting model with two candidates, C0 and C1. We consider two types of voters—herders and independents. The voting of independents is based on their fundamental values, while the voting of herders is based on the number of previous votes. We can identify two kinds of phase transitions. One is an information cascade transition similar to a phase transition seen in the Ising model. The other is a transition of super and normal diffusions. These phase transitions coexist. We compared our results to the conclusions of experiments and identified the phase transitions in the upper limit of the time t by using the analysis of human behavior obtained from experiments.

  2. Nonequilibrium Phase Transition in a Model for Social Influence

    NASA Astrophysics Data System (ADS)

    Castellano, Claudio; Marsili, Matteo; Vespignani, Alessandro

    2000-10-01

    We present extensive numerical simulations of the Axelrod's model for social influence, aimed at understanding the formation of cultural domains. This is a nonequilibrium model with short range interactions and a remarkably rich dynamical behavior. We study the phase diagram of the model and uncover a nonequilibrium phase transition separating an ordered (culturally polarized) phase from a disordered (culturally fragmented) one. The nature of the phase transition can be continuous or discontinuous depending on the model parameters. At the transition, the size of cultural regions is power-law distributed.

  3. Introduction to symposium on unmeasured heterogeneity in school transition models

    PubMed Central

    Mare, Robert D.

    2014-01-01

    Researchers have used models of school transitions for over 30 years to describe inequality of educational opportunity and have contributed a number of important refinements and extensions. School transition models have the complication that the estimated effects of family background on the probability of continuing in school are affected by differential attrition on unobserved factors at earlier stages of schooling. The articles in this symposium present a variety of useful approaches to unobserved heterogeneity in school transition models. Investigators who use these approaches should attend to several issues: (1) models for school transitions may be used both descriptively (and are not therefore subject to any well-defined “bias”) and as tools for causal inference. (2) The concept of bias presupposes an underlying experiment, structural model, or population model that would, in principle, define the corresponding unbiased parameters – yet these underlying models are difficult to specify for school transition models. (3) Unobserved determinants of whether individuals make school transitions may be both exogenous and endogenous with respect to the observed regressors in the model. Without a model of how unobserved heterogeneity arises, attempted “corrections” for unmeasured heterogeneity may yield misleading estimates of the effects of measured determinants of school continuation. PMID:24882915

  4. Between the Rock and a Hard Place: The CCMC as a Transit Station Between Modelers and Forecasters

    NASA Technical Reports Server (NTRS)

    Hesse, Michael

    2009-01-01

    The Community Coordinated Modeling Center (CCMC) is a US inter-agency activity aiming at research in support of the generation of advanced space weather models. As one of its main functions, the CCMC provides to researchers the use of space science models, even if they are not model owners themselves. The second CCMC activity is to support Space Weather forecasting at national Space Weather Forecasting Centers. This second activity involved model evaluations, model transitions to operations, and the development of draft Space Weather forecasting tools. This presentation will focus on the latter element. Specifically, we will discuss the process of transition research models, or information generated by research models, to Space Weather Forecasting organizations. We will analyze successes as well as obstacles to further progress, and we will suggest avenues for increased transitioning success.

  5. On a viscous critical-stress model of martensitic phase transitions

    NASA Astrophysics Data System (ADS)

    Weatherwax, John; Vaynblat, Dimitri; Bruno, Oscar; Rosales, Ruben

    2007-09-01

    The solid-to-solid phase transitions that result from shock loading of certain materials, such as the graphite-to-diamond transition and the α-ɛ transition in iron, have long been subjects of a substantial theoretical and experimental literature. Recently a model for such transitions was introduced which, based on a CS condition (CS) and without use of fitting parameters, accounts quantitatively for existing observations in a number of systems [Bruno and Vaynblat, Proc. R. Soc. London, Ser. A 457, 2871 (2001)]. While the results of the CS model match the main features of the available experimental data, disagreements in some details between the predictions of this model and experiment, attributable to an ideal character of the CS model, do exist. In this article we present a version of the CS model, the viscous CS model (vCS), as well as a numerical method for its solution. This model and the corresponding solver results in a much improved overall CS modeling capability. The innovations we introduce include: (1) Enhancement of the model by inclusion of viscous phase-transition effects; as well as a numerical solver that allows for a fully rigorous treatment of both, the (2) Rarefaction fans (which had previously been approximated by "rarefaction discontinuities"), and (3) viscous phase-transition effects, that are part of the vCS model. In particular we show that the vCS model accounts accurately for well known "gradual" rises in the α-ɛ transition which, in the original CS model, were somewhat crudely approximated as jump discontinuities.

  6. Dislocation dynamics modelling of the ductile-brittle-transition

    NASA Astrophysics Data System (ADS)

    Hennecke, Thomas; Hähner, Peter

    2009-07-01

    Many materials like silicon, tungsten or ferritic steels show a transition between high temperature ductile fracture with stable crack grow and high deformation energy absorption and low temperature brittle fracture in an unstable and low deformation mode, the ductile-brittle-transition. Especially in steels, the temperature transition is accompanied by a strong increase of the measured fracture toughness over a certain temperature range and strong scatter in the toughness data in this transition regime. The change in fracture modes is affected by dynamic interactions between dislocations and the inhomogeneous stress fields of notches and small cracks. In the present work a dislocation dynamics model for the ductile-brittle-transition is proposed, which takes those interactions into account. The model can explain an increase with temperature of apparent toughness in the quasi-brittle regime and different levels of scatter in the different temperature regimes. Furthermore it can predict changing failure sites in materials with heterogeneous microstructure. Based on the model, the effects of crack tip blunting, stress state, external strain rate and irradiation-induced changes in the plastic flow properties can be discussed.

  7. Evidence-based transition to practice: developing a model for North Carolina.

    PubMed

    Johnson, Mary P; Roth, Joyce W; Jenkins, Pamela R

    2011-01-01

    To enhance patient safety and increase retention of new nurses, structures and processes should be developed to ensure that newly licensed nurses are afforded the opportunity to gain confidence and competence as they enter the workforce. This commentary provides an overview of the work performed to date in North Carolina to build an evidence-based transition-to-practice model.

  8. Betting on change: modeling transitional probabilities to guide therapy development for opioid dependence.

    PubMed

    Carpenter, Kenneth M; Jiang, Huiping; Sullivan, Maria A; Bisaga, Adam; Comer, Sandra D; Raby, Wilfrid Noel; Brooks, Adam C; Nunes, Edward V

    2009-03-01

    This study investigated the process of change by modeling transitions among four clinical states encountered in 64 detoxified opiate-dependent individuals treated with daily oral naltrexone: no opiate use, blocked opiate use (i.e., opiate use while adhering to oral naltrexone), unblocked opiate use (i.e., opiate use after having discontinued oral naltrexone), and treatment dropout. The effects of baseline characteristics and two psychosocial interventions of differing intensity, behavioral naltrexone therapy (BNT) and compliance enhancement (CE), on these transitions were studied. Participants using greater quantities of opiates were more likely than other participants to be retained in BNT relative to CE. Markov modeling indicated a transition from abstinence to treatment dropout was approximately 3.56 times greater among participants in CE relative to participants in BNT, indicating the more comprehensive psychosocial intervention kept participants engaged in treatment longer. Transitions to stopping treatment were more likely to occur after unblocked opiate use in both treatments. Continued opiate use while being blocked accounted for a relatively low proportion of transitions to abstinence and may have more deleterious effects later in a treatment episode. (PsycINFO Database Record (c) 2009 APA, all rights reserved).

  9. A transition-based joint model for disease named entity recognition and normalization.

    PubMed

    Lou, Yinxia; Zhang, Yue; Qian, Tao; Li, Fei; Xiong, Shufeng; Ji, Donghong

    2017-08-01

    Disease named entities play a central role in many areas of biomedical research, and automatic recognition and normalization of such entities have received increasing attention in biomedical research communities. Existing methods typically used pipeline models with two independent phases: (i) a disease named entity recognition (DER) system is used to find the boundaries of mentions in text and (ii) a disease named entity normalization (DEN) system is used to connect the mentions recognized to concepts in a controlled vocabulary. The main problems of such models are: (i) there is error propagation from DER to DEN and (ii) DEN is useful for DER, but pipeline models cannot utilize this. We propose a transition-based model to jointly perform disease named entity recognition and normalization, casting the output construction process into an incremental state transition process, learning sequences of transition actions globally, which correspond to joint structural outputs. Beam search and online structured learning are used, with learning being designed to guide search. Compared with the only existing method for joint DEN and DER, our method allows non-local features to be used, which significantly improves the accuracies. We evaluate our model on two corpora: the BioCreative V Chemical Disease Relation (CDR) corpus and the NCBI disease corpus. Experiments show that our joint framework achieves significantly higher performances compared to competitive pipeline baselines. Our method compares favourably to other state-of-the-art approaches. Data and code are available at https://github.com/louyinxia/jointRN. dhji@whu.edu.cn. © The Author (2017). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com

  10. A Simple Model for Complex Dynamical Transitions in Epidemics

    NASA Astrophysics Data System (ADS)

    Earn, David J. D.; Rohani, Pejman; Bolker, Benjamin M.; Grenfell, Bryan T.

    2000-01-01

    Dramatic changes in patterns of epidemics have been observed throughout this century. For childhood infectious diseases such as measles, the major transitions are between regular cycles and irregular, possibly chaotic epidemics, and from regionally synchronized oscillations to complex, spatially incoherent epidemics. A simple model can explain both kinds of transitions as the consequences of changes in birth and vaccination rates. Measles is a natural ecological system that exhibits different dynamical transitions at different times and places, yet all of these transitions can be predicted as bifurcations of a single nonlinear model.

  11. Exploration of government policy structure which support and block energy transition process in indonesia using system dynamics model

    NASA Astrophysics Data System (ADS)

    Destyanto, A. R.; Silalahi, T. D.; Hidayatno, A.

    2017-11-01

    System dynamic modeling is widely used to predict and simulate the energy system in several countries. One of the applications of system dynamics is to evaluate national energy policy alternatives, and energy efficiency analysis. Using system dynamic modeling, this research aims to evaluate the energy transition policy that has been implemented in Indonesia on the past conversion program of kerosene to LPG for household cook fuel consumption, which considered as successful energy transition program implemented since 2007. This research is important since Indonesia considered not yet succeeded to execute another energy transition program on conversion program of oil fuel to gas fuel for transportation that has started since 1989. The aim of this research is to explore which policy intervention that has significant contribution to support or even block the conversion program. Findings in this simulation show that policy intervention to withdraw the kerosene supply and government push to increase production capacity of the support equipment industries (gas stove, regulator, and LPG Cylinder) is the main influence on the success of the program conversion program.

  12. Transitional Jobs: Background, Program Models, and Evaluation Evidence

    ERIC Educational Resources Information Center

    Bloom, Dan

    2010-01-01

    The budget for the U.S. Department of Labor for Fiscal Year 2010 includes a total of $45 million to support and study transitional jobs. This paper describes the origins of the transitional jobs models that are operating today, reviews the evidence on the effectiveness of this approach and other subsidized employment models, and offers some…

  13. Social Influence and Selection Processes as Predictors of Normative Perceptions and Alcohol Use across the Transition to College

    ERIC Educational Resources Information Center

    Abar, Caitlin C.; Maggs, Jennifer L.

    2010-01-01

    Research indicates that social influences impact college students' alcohol consumption; however, how selection processes may serve as an influential factor predicting alcohol use in this population has not been widely addressed. A model of influence and selection processes contributing to alcohol use across the transition to college was examined…

  14. Implementation of a Transition Model in a NASA Code and Validation Using Heat Transfer Data on a Turbine Blade

    NASA Technical Reports Server (NTRS)

    Ameri, Ali A.

    2012-01-01

    The purpose of this report is to summarize and document the work done to enable a NASA CFD code to model laminar-turbulent transition process on an isolated turbine blade. The ultimate purpose of the present work is to down-select a transition model that would allow the flow simulation of a variable speed power turbine to be accurately performed. The flow modeling in its final form will account for the blade row interactions and their effects on transition which would lead to accurate accounting for losses. The present work only concerns itself with steady flows of variable inlet turbulence. The low Reynolds number k- model of Wilcox and a modified version of the same model will be used for modeling of transition on experimentally measured blade pressure and heat transfer. It will be shown that the k- model and its modified variant fail to simulate the transition with any degree of accuracy. A case is thus made for the adoption of more accurate transition models. Three-equation models based on the work of Mayle on Laminar Kinetic Energy were explored. The three-equation model of Walters and Leylek was thought to be in a relatively mature state of development and was implemented in the Glenn-HT code. Two-dimensional heat transfer predictions of flat plate flow and two-dimensional and three-dimensional heat transfer predictions on a turbine blade were performed and reported herein. Surface heat transfer rate serves as sensitive indicator of transition. With the newly implemented model, it was shown that the simulation of transition process is much improved over the baseline k- model for the single Reynolds number and pressure ratio attempted; while agreement with heat transfer data became more satisfactory. Armed with the new transition model, total-pressure losses of computed three-dimensional flow of E3 tip section cascade were compared to the experimental data for a range of incidence angles. The results obtained, form a partial loss bucket for the chosen blade

  15. Phase transitions in tumor growth VI: Epithelial-Mesenchymal transition

    NASA Astrophysics Data System (ADS)

    Guerra, A.; Rodriguez, D. J.; Montero, S.; Betancourt-Mar, J. A.; Martin, R. R.; Silva, E.; Bizzarri, M.; Cocho, G.; Mansilla, R.; Nieto-Villar, J. M.

    2018-06-01

    Herewith we discuss a network model of the epithelial-mesenchymal transition (EMT) based on our previous proposed framework. The EMT appears as a "first order" phase transition process, analogous to the transitions observed in the chemical-physical field. Chiefly, EMT should be considered a transition characterized by a supercritical Andronov-Hopf bifurcation, with the emergence of limit cycle and, consequently, a cascade of saddle-foci Shilnikov's bifurcations. We eventually show that the entropy production rate is an EMT-dependent function and, as such, its formalism reminds the van der Waals equation.

  16. Development of a One-Equation Transition/Turbulence Model

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    EDWARDS,JACK R.; ROY,CHRISTOPHER J.; BLOTTNER,FREDERICK G.

    2000-09-26

    This paper reports on the development of a unified one-equation model for the prediction of transitional and turbulent flows. An eddy viscosity - transport equation for non-turbulent fluctuation growth based on that proposed by Warren and Hassan (Journal of Aircraft, Vol. 35, No. 5) is combined with the Spalart-Allmaras one-equation model for turbulent fluctuation growth. Blending of the two equations is accomplished through a multidimensional intermittence function based on the work of Dhawan and Narasimha (Journal of Fluid Mechanics, Vol. 3, No. 4). The model predicts both the onset and extent of transition. Low-speed test cases include transitional flow overmore » a flat plate, a single element airfoil, and a multi-element airfoil in landing configuration. High-speed test cases include transitional Mach 3.5 flow over a 5{degree} cone and Mach 6 flow over a flared-cone configuration. Results are compared with experimental data, and the spatial accuracy of selected predictions is analyzed.« less

  17. Phase transition solutions in geometrically constrained magnetic domain wall models

    NASA Astrophysics Data System (ADS)

    Chen, Shouxin; Yang, Yisong

    2010-02-01

    Recent work on magnetic phase transition in nanoscale systems indicates that new physical phenomena, in particular, the Bloch wall width narrowing, arise as a consequence of geometrical confinement of magnetization and leads to the introduction of geometrically constrained domain wall models. In this paper, we present a systematic mathematical analysis on the existence of the solutions of the basic governing equations in such domain wall models. We show that, when the cross section of the geometric constriction is a simple step function, the solutions may be obtained by minimizing the domain wall energy over the constriction and solving the Bogomol'nyi equation outside the constriction. When the cross section and potential density are both even, we establish the existence of an odd domain wall solution realizing the phase transition process between two adjacent domain phases. When the cross section satisfies a certain integrability condition, we prove that a domain wall solution always exists which links two arbitrarily designated domain phases.

  18. A Micromechanics-Based Elastoplastic Damage Model for Rocks with a Brittle-Ductile Transition in Mechanical Response

    NASA Astrophysics Data System (ADS)

    Hu, Kun; Zhu, Qi-zhi; Chen, Liang; Shao, Jian-fu; Liu, Jian

    2018-06-01

    As confining pressure increases, crystalline rocks of moderate porosity usually undergo a transition in failure mode from localized brittle fracture to diffused damage and ductile failure. This transition has been widely reported experimentally for several decades; however, satisfactory modeling is still lacking. The present paper aims at modeling the brittle-ductile transition process of rocks under conventional triaxial compression. Based on quantitative analyses of experimental results, it is found that there is a quite satisfactory linearity between the axial inelastic strain at failure and the confining pressure prescribed. A micromechanics-based frictional damage model is then formulated using an associated plastic flow rule and a strain energy release rate-based damage criterion. The analytical solution to the strong plasticity-damage coupling problem is provided and applied to simulate the nonlinear mechanical behaviors of Tennessee marble, Indiana limestone and Jinping marble, each presenting a brittle-ductile transition in stress-strain curves.

  19. Phase Transitions in the Quadratic Contact Process on Complex Networks

    NASA Astrophysics Data System (ADS)

    Varghese, Chris; Durrett, Rick

    2013-03-01

    The quadratic contact process (QCP) is a natural extension of the well studied linear contact process where a single infected (1) individual can infect a susceptible (0) neighbor and infected individuals are allowed to recover (1 --> 0). In the QCP, a combination of two 1's is required to effect a 0 --> 1 change. We extend the study of the QCP, which so far has been limited to lattices, to complex networks as a model for the change in a population via sexual reproduction and death. We define two versions of the QCP - vertex centered (VQCP) and edge centered (EQCP) with birth events 1 - 0 - 1 --> 1 - 1 - 1 and 1 - 1 - 0 --> 1 - 1 - 1 respectively, where ` -' represents an edge. We investigate the effects of network topology by considering the QCP on regular, Erdős-Rényi and power law random graphs. We perform mean field calculations as well as simulations to find the steady state fraction of occupied vertices as a function of the birth rate. We find that on the homogeneous graphs (regular and Erdős-Rényi) there is a discontinuous phase transition with a region of bistability, whereas on the heavy tailed power law graph, the transition is continuous. The critical birth rate is found to be positive in the former but zero in the latter.

  20. Modeling dynamic beta-gamma polymorphic transition in Tin

    NASA Astrophysics Data System (ADS)

    Chauvin, Camille; Montheillet, Frank; Petit, Jacques; CEA Gramat Collaboration; EMSE Collaboration

    2015-06-01

    Solid-solid phase transitions in metals have been studied by shock waves techniques for many decades. Recent experiments have investigated the transition during isentropic compression experiments and shock-wave compression and have highlighted the strong influence of the loading rate on the transition. Complementary data obtained with velocity and temperature measurements around the polymorphic transition beta-gamma of Tin on gas gun experiments have displayed the importance of the kinetics of the transition. But, even though this phenomenon is known, modeling the kinetic remains complex and based on empirical formulations. A multiphase EOS is available in our 1D Lagrangian code Unidim. We propose to present the influence of various kinetic laws (either empirical or involving nucleation and growth mechanisms) and their parameters (Gibbs free energy, temperature, pressure) on the transformation rate. We compare experimental and calculated velocities and temperature profiles and we underline the effects of the empirical parameters of these models.

  1. Self-organization in psychotherapy: testing the synergetic model of change processes

    PubMed Central

    Schiepek, Günter K.; Tominschek, Igor; Heinzel, Stephan

    2014-01-01

    In recent years, models have been developed that conceive psychotherapy as a self-organizing process of bio-psycho-social systems. These models originate from the theory of self-organization (Synergetics), from the theory of deterministic chaos, or from the approach of self-organized criticality. This process-outcome study examines several hypotheses mainly derived from Synergetics, including the assumption of discontinuous changes in psychotherapy (instead of linear incremental gains), the occurrence of critical instabilities in temporal proximity of pattern transitions, the hypothesis of necessary stable boundary conditions during destabilization processes, and of motivation to change playing the role of a control parameter for psychotherapeutic self-organization. Our study was realized at a day treatment center; 23 patients with obsessive compulsive disorder (OCD) were included. Client self-assessment was performed by an Internet-based process monitoring (referred to as the Synergetic Navigation System), whereby daily ratings were recorded through administering the Therapy Process Questionnaire (TPQ). The process measures of the study were extracted from the subscale dynamics (including the dynamic complexity of their time series) of the TPQ. The outcome criterion was measured by the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) which was completed pre-post and on a bi-weekly schedule by all patients. A second outcome criterion was based on the symptom severity subscale of the TPQ. Results supported the hypothesis of discontinuous changes (pattern transitions), the occurrence of critical instabilities preparing pattern transitions, and of stable boundary conditions as prerequisites for such transitions, but not the assumption of motivation to change as a control parameter. PMID:25324801

  2. Self-organization in psychotherapy: testing the synergetic model of change processes.

    PubMed

    Schiepek, Günter K; Tominschek, Igor; Heinzel, Stephan

    2014-01-01

    In recent years, models have been developed that conceive psychotherapy as a self-organizing process of bio-psycho-social systems. These models originate from the theory of self-organization (Synergetics), from the theory of deterministic chaos, or from the approach of self-organized criticality. This process-outcome study examines several hypotheses mainly derived from Synergetics, including the assumption of discontinuous changes in psychotherapy (instead of linear incremental gains), the occurrence of critical instabilities in temporal proximity of pattern transitions, the hypothesis of necessary stable boundary conditions during destabilization processes, and of motivation to change playing the role of a control parameter for psychotherapeutic self-organization. Our study was realized at a day treatment center; 23 patients with obsessive compulsive disorder (OCD) were included. Client self-assessment was performed by an Internet-based process monitoring (referred to as the Synergetic Navigation System), whereby daily ratings were recorded through administering the Therapy Process Questionnaire (TPQ). The process measures of the study were extracted from the subscale dynamics (including the dynamic complexity of their time series) of the TPQ. The outcome criterion was measured by the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) which was completed pre-post and on a bi-weekly schedule by all patients. A second outcome criterion was based on the symptom severity subscale of the TPQ. Results supported the hypothesis of discontinuous changes (pattern transitions), the occurrence of critical instabilities preparing pattern transitions, and of stable boundary conditions as prerequisites for such transitions, but not the assumption of motivation to change as a control parameter.

  3. Transition Characteristic Analysis of Traffic Evolution Process for Urban Traffic Network

    PubMed Central

    Chen, Hong; Li, Yang

    2014-01-01

    The characterization of the dynamics of traffic states remains fundamental to seeking for the solutions of diverse traffic problems. To gain more insights into traffic dynamics in the temporal domain, this paper explored temporal characteristics and distinct regularity in the traffic evolution process of urban traffic network. We defined traffic state pattern through clustering multidimensional traffic time series using self-organizing maps and construct a pattern transition network model that is appropriate for representing and analyzing the evolution progress. The methodology is illustrated by an application to data flow rate of multiple road sections from Network of Shenzhen's Nanshan District, China. Analysis and numerical results demonstrated that the methodology permits extracting many useful traffic transition characteristics including stability, preference, activity, and attractiveness. In addition, more information about the relationships between these characteristics was extracted, which should be helpful in understanding the complex behavior of the temporal evolution features of traffic patterns. PMID:24982969

  4. Graphite to ultrafine nanocrystalline diamond phase transition model and growth restriction mechanism induced by nanosecond laser processing

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ren, X. D., E-mail: renxd@mail.ujs.edu.cn; Liu, R.; Zheng, L. M.

    2015-10-05

    To have a clear insight into nanocrystal growth from graphite to diamond upon high energy pulsed laser irradiation of graphite suspension, synthesis of ultrafine nanocrystalline diamonds with laser energy set up from 0.3 J to 12 J, repetition rate of 10 Hz has been studied. The method allows synthesizing ultrafine nanocrystalline particles continuously at the ambient temperature and normal pressure. The particle size is shown independent of laser energy, which is ultrafine and ranges in 2–6 nm. The theoretical grown size of nano-diamonds is found in well agreement with the experiment results. Four kinds of production were found: nano-diamond, spherical carbon nano-particles, flocculent amorphousmore » carbon, and graphene nano-ribbon rolls. A solid-vapor-plasma-liquid coexistence model describing phase transition from graphite to diamond induced by nanosecond laser processing was proposed. Graphene nano-ribbon rolls might be the intermediate phase in the conversion from graphite to diamond.« less

  5. Phase transitions in a multistate majority-vote model on complex networks

    NASA Astrophysics Data System (ADS)

    Chen, Hanshuang; Li, Guofeng

    2018-06-01

    We generalize the original majority-vote (MV) model from two states to arbitrary p states and study the order-disorder phase transitions in such a p -state MV model on complex networks. By extensive Monte Carlo simulations and a mean-field theory, we show that for p ≥3 the order of phase transition is essentially different from a continuous second-order phase transition in the original two-state MV model. Instead, for p ≥3 the model displays a discontinuous first-order phase transition, which is manifested by the appearance of the hysteresis phenomenon near the phase transition. Within the hysteresis loop, the ordered phase and disordered phase are coexisting, and rare flips between the two phases can be observed due to the finite-size fluctuation. Moreover, we investigate the type of phase transition under a slightly modified dynamics [Melo et al., J. Stat. Mech. (2010) P11032, 10.1088/1742-5468/2010/11/P11032]. We find that the order of phase transition in the three-state MV model depends on the degree heterogeneity of networks. For p ≥4 , both dynamics produce the first-order phase transitions.

  6. Towards predictive models for transitionally rough surfaces

    NASA Astrophysics Data System (ADS)

    Abderrahaman-Elena, Nabil; Garcia-Mayoral, Ricardo

    2017-11-01

    We analyze and model the previously presented decomposition for flow variables in DNS of turbulence over transitionally rough surfaces. The flow is decomposed into two contributions: one produced by the overlying turbulence, which has no footprint of the surface texture, and one induced by the roughness, which is essentially the time-averaged flow around the surface obstacles, but modulated in amplitude by the first component. The roughness-induced component closely resembles the laminar steady flow around the roughness elements at the same non-dimensional roughness size. For small - yet transitionally rough - textures, the roughness-free component is essentially the same as over a smooth wall. Based on these findings, we propose predictive models for the onset of the transitionally rough regime. Project supported by the Engineering and Physical Sciences Research Council (EPSRC).

  7. Description of transitional nuclei in the sdg boson model

    NASA Astrophysics Data System (ADS)

    Lac, V.-S.; Kuyucak, S.

    1992-03-01

    We study the transitional nuclei in the framework of the sdg boson model. This extension is necessitated by recent measurements of E2 and E4 transitions in the Pt and Os isotopes which can not be explained in the sd boson models. We show how γ-unstable and triaxial shapes arise from special choices of sdg model hamiltonians and discuss ways of limiting the number of free parameters through consistency and coherence conditions. A satisfactory description of E2 and E4 properties is obtained for the Pt and Os nuclei, which also predicts dynamic shape transitions in these nuclei.

  8. Searching for the missing pieces between the hospital and primary care: mapping the patient process during care transitions.

    PubMed

    Johnson, Julie K; Farnan, Jeanne M; Barach, Paul; Hesselink, Gijs; Wollersheim, Hub; Pijnenborg, Loes; Kalkman, Cor; Arora, Vineet M

    2012-12-01

    Safe patient transitions depend on effective communication and a functioning care coordination process. Evidence suggests that primary care physicians are not satisfied with communication at transition points between inpatient and ambulatory care, and that communication often is not provided in a timely manner, omits essential information, or contains ambiguities that put patients at risk. Our aim was to demonstrate how process mapping can illustrate current handover practices between ambulatory and inpatient care settings, identify existing barriers and facilitators to effective transitions of care, and highlight potential areas for quality improvement. We conducted focus group interviews to facilitate a process mapping exercise with clinical teams in six academic health centres in the USA, Poland, Sweden, Italy, Spain and the Netherlands. At a high level, the process of patient admission to the hospital through the emergency department, inpatient care, and discharge back in the community were comparable across sites. In addition, the process maps highlighted similar barriers to providing information to primary care physicians, inaccurate or incomplete information on referral and discharge, a lack of time and priority to collaborate with counterpart colleagues, and a lack of feedback to clinicians involved in the handovers. Process mapping is effective in bringing together key stakeholders and makes explicit the mental models that frame their understanding of the clinical process. Exploring the barriers and facilitators to safe and reliable patient transitions highlights opportunities for further improvement work and illustrates ideas for best practices that might be transferrable to other settings.

  9. Modeling the impact of roadway emissions in light wind, stable and transition conditions

    EPA Science Inventory

    This paper examines the processes that govern air pollution dispersion under light wind, stable and transition conditions by using a state-of-the-art dispersion model to interpret measurements from a tracer experiment conducted next to US highway 99 in Sacramento in 1981–1982 dur...

  10. Process for preparing high-transition-temperature superconductors in the Nb-Al-Ge system

    DOEpatents

    Giorgi, A.L.; Szklarz, E.G.

    1973-01-30

    The patent describes a process for preparing superconducting materials in the Nb-Al-Ge system having transition temperatures in excess of 19K. The process comprises premixing powdered constituents, pressing them into a plug, heating the plug to 1,450-1,800C for 30 minutes to an hour under vacuum or an inert atmosphere, and annealing at moderate temperatures for reasonably long times (approximately 50 hours). High transition-temperature superconductors, including those in the Nb3(Al,Ge) system, prepared in accordance with this process exhibit little degradation in the superconducting transition temperature on being ground to -200 mesh powder. (GRA)

  11. A Model for NASA-KSC's Privatization Transition

    NASA Technical Reports Server (NTRS)

    Lavelle, Jerome P.; Krumwiede, Dennis W.; Flowers, Jean

    1996-01-01

    This paper describes a model for government agencies that are considering privatization of all or part of their functions. Privatization encompasses the transitioning of government functions from government run to contractor run. The model developed in this paper is used to analyze the National Aeronautics and Space Administration's (NASA) decision to privatize space shuttle operations at the Kennedy Space Center (KSC). Several specific recommendations are given to KSC as they attempt to operationalize this privatization decision at the Center and to transition to a new relationship with their contractors.

  12. Dynamic shape transitions in the sdg boson model

    NASA Astrophysics Data System (ADS)

    Kuyucak, S.

    The dynamic evolution of shapes in the sdg interacting boson model is investigated using the angular momentum projected mean field theory. Deformed nuclei are found to be quite stable against shape changes but transitional nuclei could exhibit dynamic shape transitions in the region L = 10-20. Conditions of existence and experimental signatures for dynamic shape transitions are discussed together with a likely candidate, 192Os.

  13. Light Scattering in Exoplanet Transits

    NASA Astrophysics Data System (ADS)

    Robinson, Tyler D.; Fortney, Jonathan J.

    2016-10-01

    Transit spectroscopy is currently the leading technique for studying exoplanet atmospheric composition, and has led to the detection of molecular species, clouds, and/or hazes for numerous worlds outside the Solar System. The field of exoplanet transit spectroscopy will be revolutionized with the anticipated launch of NASA's James Webb Space Telescope (JWST) in 2018. Over the course of the design five year mission for JWST, the observatory is expected to provide in-depth observations of many tens of transiting exoplanets, including some worlds in the poorly understood 2-4 Earth-mass regime. As the quality of transit spectrum observations continues to improve, so should models of exoplanet transits. Thus, certain processes initially thought to be of second-order importance should be revisited and possibly added to modeling tools. For example, atmospheric refraction, which was commonly omitted from early transit spectrum models, has recently been shown to be of critical importance in some terrestrial exoplanet transits. Beyond refraction, another process that has seen little study with regards to exoplanet transits is light multiple scattering. In most cases, scattering opacity in exoplanet transits has been treated as equivalent to absorption opacity. However, this equivalence cannot always hold, such as in the case of a strongly forward scattering, weakly absorbing aerosol. In this presentation, we outline a theory of exoplanet transit spectroscopy that spans the geometric limit (used in most modern models) to a fully multiple scattering approach. We discuss a new technique for improving model efficiency that effectively separates photon paths, which tend to vary slowly in wavelength, from photon absorption, which can vary rapidly in wavelength. Using this newly developed approach, we explore situations where cloud or haze scattering may be important to JWST observations of gas giants, and comment on the conditions necessary for scattering to become a major

  14. Noise Prediction Models for Elevated Rail Transit Structures

    DOT National Transportation Integrated Search

    1975-08-01

    The report presents the theoretical development of a model for the prediction of noise radiated by elevated structures on rail transit lines. In particular it deals with noise and vibration control for urban rail transit track and elevated noise and ...

  15. Modelling Phase Transition Phenomena in Fluids

    DTIC Science & Technology

    2015-07-01

    Sublimation line r @@I Triple point ? Vapourisation liner @@I Critical point -Fusion line Solid Liquid Gas Figure 1: Schematic of a phase diagram means that the...velocity field can be set zero, and only the balance of energy constitutes the Stefan model. In contrast to this the liquid - gas phase transitions...defined by requiring that the phase-transition line is crossed in a direction from solid to liquid or from liquid to gas (vapour) phases. The term T∗ δs is

  16. Characterizing Phase Transitions in a Model of Neutral Evolutionary Dynamics

    NASA Astrophysics Data System (ADS)

    Scott, Adam; King, Dawn; Bahar, Sonya

    2013-03-01

    An evolutionary model was recently introduced for sympatric, phenotypic evolution over a variable fitness landscape with assortative mating (Dees & Bahar 2010). Organisms in the model are described by coordinates in a two-dimensional phenotype space, born at random coordinates with limited variation from their parents as determined by a mutation parameter, mutability. The model has been extended to include both neutral evolution and asexual reproduction in Scott et al (submitted). It has been demonstrated that a second order, non-equilibrium phase transition occurs for the temporal dynamics as the mutability is varied, for both the original model and for neutral conditions. This transition likely belongs to the directed percolation universality class. In contrast, the spatial dynamics of the model shows characteristics of an ordinary percolation phase transition. Here, we characterize the phase transitions exhibited by this model by determining critical exponents for the relaxation times, characteristic lengths, and cluster (species) mass distributions. Missouri Research Board; J.S. McDonnell Foundation

  17. Investigation of bus transit schedule behavior modeling using advanced techniques

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kalaputapu, R.; Demetsky, M.J.

    This research focused on investigating the application of artificial neural networks (ANN) and the Box-Jenkins technique for developing and testing schedule behavior models using data obtained for a test route from Tidewater Regional Transit`s AVL system. The three ANN architectures investigated were: Feedforward Network, Elman Network and Jordan Network. In addition, five different model structures were investigated. The time-series methodology was adopted for developing the schedule behavior models. Finally, the role of a schedule behavior model within the framework of an intelligent transit management system is defined and the potential utility of the schedule behavior model is discussed using anmore » example application.« less

  18. Urban public transit systems modeling capabilities

    DOT National Transportation Integrated Search

    1995-02-01

    Current national transportation policy places increasing emphasis on multi-modal : solutions involving public transit and high-occupancy vehicle (HOV) facilities : and services. Current traffic simulation/assignment models, however, have only : limit...

  19. Global quantum discord and quantum phase transition in XY model

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Liu, Si-Yuan; Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190; Zhang, Yu-Ran, E-mail: yrzhang@iphy.ac.cn

    We study the relationship between the behavior of global quantum correlations and quantum phase transitions in XY model. We find that the two kinds of phase transitions in the studied model can be characterized by the features of global quantum discord (GQD) and the corresponding quantum correlations. We demonstrate that the maximum of the sum of all the nearest neighbor bipartite GQDs is effective and accurate for signaling the Ising quantum phase transition, in contrast, the sudden change of GQD is very suitable for characterizing another phase transition in the XY model. This may shed lights on the study ofmore » properties of quantum correlations in different quantum phases.« less

  20. Turbulence Modeling for the Simulation of Transition in Wall Shear Flows

    NASA Technical Reports Server (NTRS)

    Crawford, Michael E.

    2007-01-01

    Our research involves study of the behavior of k-epsilon turbulence models for simulation of bypass-level transition over flat surfaces and turbine blades. One facet of the research has been to assess the performance of a multitude of k-epsilon models in what we call "natural transition", i.e. no modifications to the k-e models. The study has been to ascertain what features in the dynamics of the model affect the start and end of the transition. Some of the findings are in keeping with those reported by others (e.g. ERCOFTAC). A second facet of the research has been to develop and benchmark a new multi-time scale k-epsilon model (MTS) for use in simulating bypass-level transition. This model has certain features of the published MTS models by Hanjalic, Launder, and Schiestel, and by Kim and his coworkers. The major new feature of our MTS model is that it can be used to compute wall shear flows as a low-turbulence Reynolds number type of model, i.e. there is no required partition with patching a one-equation k model in the near-wall region to a two-equation k-epsilon model in the outer part of the flow. Our MTS model has been studied extensively to understand its dynamics in predicting the onset of transition and the end-stage of the transition. Results to date indicate that it far superior to the standard unmodified k-epsilon models. The effects of protracted pressure gradients on the model behavior are currently being investigated.

  1. Multi-state succession in wetlands: a novel use of state and transition models

    USGS Publications Warehouse

    Zweig, Christa L.; Kitchens, Wiley M.

    2009-01-01

    The complexity of ecosystems and mechanisms of succession are often simplified by linear and mathematical models used to understand and predict system behavior. Such models often do not incorporate multivariate, nonlinear feedbacks in pattern and process that include multiple scales of organization inherent within real-world systems. Wetlands are ecosystems with unique, nonlinear patterns of succession due to the regular, but often inconstant, presence of water on the landscape. We develop a general, nonspatial state and transition (S and T) succession conceptual model for wetlands and apply the general framework by creating annotated succession/management models and hypotheses for use in impact analysis on a portion of an imperiled wetland. The S and T models for our study area, Water Conservation Area 3A South (WCA3), Florida, USA, included hydrologic and peat depth values from multivariate analyses and classification and regression trees. We used the freeware Vegetation Dynamics Development Tool as an exploratory application to evaluate our S and T models with different management actions (equal chance [a control condition], deeper conditions, dry conditions, and increased hydrologic range) for three communities: slough, sawgrass (Cladium jamaicense), and wet prairie. Deeper conditions and increased hydrologic range behaved similarly, with the transition of community states to deeper states, particularly for sawgrass and slough. Hydrology is the primary mechanism for multi-state transitions within our study period, and we show both an immediate and lagged effect on vegetation, depending on community state. We consider these S and T succession models as a fraction of the framework for the Everglades. They are hypotheses for use in adaptive management, represent the community response to hydrology, and illustrate which aspects of hydrologic variability are important to community structure. We intend for these models to act as a foundation for further restoration

  2. Simulating Society Transitions: Standstill, Collapse and Growth in an Evolving Network Model

    PubMed Central

    Xu, Guanghua; Yang, Junjie; Li, Guoqing

    2013-01-01

    We developed a model society composed of various occupations that interact with each other and the environment, with the capability of simulating three widely recognized societal transition patterns: standstill, collapse and growth, which are important compositions of society evolving dynamics. Each occupation is equipped with a number of inhabitants that may randomly flow to other occupations, during which process new occupations may be created and then interact with existing ones. Total population of society is associated with productivity, which is determined by the structure and volume of the society. We ran the model under scenarios such as parasitism, environment fluctuation and invasion, which correspond to different driving forces of societal transition, and obtained reasonable simulation results. This work adds to our understanding of societal evolving dynamics as well as provides theoretical clues to sustainable development. PMID:24086530

  3. Vertex stability and topological transitions in vertex models of foams and epithelia

    NASA Astrophysics Data System (ADS)

    Spencer, Meryl; Jabeen, Zahera; Lubensky, David

    Vertex models are widely used to computationally simulate dry foams and epithelial tissues. This class of models describes the shape and motion of cells as a function of the forces on vertices where 3 or more cells meet. Despite the widespread use of these models, relatively little is known about their basic theoretical properties. One outstanding issue is the stability of fourfold vertices. In real foams, fourfold vertices are always unstable, but it has been unclear whether vertex models necessarily reflect this behavior. In biological tissues, fourfold vertices arise as an intermediate in T1 transitions, which are one of the fundamental processes by which tissues change topology, and stable fourfold vertices have recently been observed in several different epithelia. We show that, when all edges have the same tension, stationary fourfold vertices in vertex models must always break up. However, when tensions depend on edge orientation, as they might in a planar-polarized tissue, fourfold vertices can become stable. These findings pave the way for studies of more biologically realistic models that couple topological transitions to the dynamics of regulatory proteins. NSF Grant No. DMR-1056456 and NSF-GRFP Grant No. DGE-1256260.

  4. Modeling the glass transition of amorphous networks for shape-memory behavior

    NASA Astrophysics Data System (ADS)

    Xiao, Rui; Choi, Jinwoo; Lakhera, Nishant; Yakacki, Christopher M.; Frick, Carl P.; Nguyen, Thao D.

    2013-07-01

    In this paper, a thermomechanical constitutive model was developed for the time-dependent behaviors of the glass transition of amorphous networks. The model used multiple discrete relaxation processes to describe the distribution of relaxation times for stress relaxation, structural relaxation, and stress-activated viscous flow. A non-equilibrium thermodynamic framework based on the fictive temperature was introduced to demonstrate the thermodynamic consistency of the constitutive theory. Experimental and theoretical methods were developed to determine the parameters describing the distribution of stress and structural relaxation times and the dependence of the relaxation times on temperature, structure, and driving stress. The model was applied to study the effects of deformation temperatures and physical aging on the shape-memory behavior of amorphous networks. The model was able to reproduce important features of the partially constrained recovery response observed in experiments. Specifically, the model demonstrated a strain-recovery overshoot for cases programmed below Tg and subjected to a constant mechanical load. This phenomenon was not observed for materials programmed above Tg. Physical aging, in which the material was annealed for an extended period of time below Tg, shifted the activation of strain recovery to higher temperatures and increased significantly the initial recovery rate. For fixed-strain recovery, the model showed a larger overshoot in the stress response for cases programmed below Tg, which was consistent with previous experimental observations. Altogether, this work demonstrates how an understanding of the time-dependent behaviors of the glass transition can be used to tailor the temperature and deformation history of the shape-memory programming process to achieve more complex shape recovery pathways, faster recovery responses, and larger activation stresses.

  5. Single-Column Model Simulations of Subtropical Marine Boundary-Layer Cloud Transitions Under Weakening Inversions: SCM SIMULATIONS OF CLOUD TRANSITIONS

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Neggers, R. A. J.; Ackerman, A. S.; Angevine, W. M.

    Results are presented of the GASS/EUCLIPSE single-column model inter-comparison study on the subtropical marine low-level cloud transition. A central goal is to establish the performance of state-of-the-art boundary-layer schemes for weather and climate mod- els for this cloud regime, using large-eddy simulations of the same scenes as a reference. A novelty is that the comparison covers four different cases instead of one, in order to broaden the covered parameter space. Three cases are situated in the North-Eastern Pa- cific, while one reflects conditions in the North-Eastern Atlantic. A set of variables is considered that reflects key aspects of the transitionmore » process, making use of simple met- rics to establish the model performance. Using this method some longstanding problems in low level cloud representation are identified. Considerable spread exists among models concerning the cloud amount, its vertical structure and the associated impact on radia- tive transfer. The sign and amplitude of these biases differ somewhat per case, depending on how far the transition has progressed. After cloud breakup the ensemble median ex- hibits the well-known “too few too bright” problem. The boundary layer deepening rate and its state of decoupling are both underestimated, while the representation of the thin capping cloud layer appears complicated by a lack of vertical resolution. Encouragingly, some models are successful in representing the full set of variables, in particular the verti- cal structure and diurnal cycle of the cloud layer in transition. An intriguing result is that the median of the model ensemble performs best, inspiring a new approach in subgrid pa- rameterization.« less

  6. batman: BAsic Transit Model cAlculatioN in Python

    NASA Astrophysics Data System (ADS)

    Kreidberg, Laura

    2015-11-01

    I introduce batman, a Python package for modeling exoplanet transit light curves. The batman package supports calculation of light curves for any radially symmetric stellar limb darkening law, using a new integration algorithm for models that cannot be quickly calculated analytically. The code uses C extension modules to speed up model calculation and is parallelized with OpenMP. For a typical light curve with 100 data points in transit, batman can calculate one million quadratic limb-darkened models in 30 seconds with a single 1.7 GHz Intel Core i5 processor. The same calculation takes seven minutes using the four-parameter nonlinear limb darkening model (computed to 1 ppm accuracy). Maximum truncation error for integrated models is an input parameter that can be set as low as 0.001 ppm, ensuring that the community is prepared for the precise transit light curves we anticipate measuring with upcoming facilities. The batman package is open source and publicly available at https://github.com/lkreidberg/batman .

  7. Efficient collective influence maximization in cascading processes with first-order transitions

    PubMed Central

    Pei, Sen; Teng, Xian; Shaman, Jeffrey; Morone, Flaviano; Makse, Hernán A.

    2017-01-01

    In many social and biological networks, the collective dynamics of the entire system can be shaped by a small set of influential units through a global cascading process, manifested by an abrupt first-order transition in dynamical behaviors. Despite its importance in applications, efficient identification of multiple influential spreaders in cascading processes still remains a challenging task for large-scale networks. Here we address this issue by exploring the collective influence in general threshold models of cascading process. Our analysis reveals that the importance of spreaders is fixed by the subcritical paths along which cascades propagate: the number of subcritical paths attached to each spreader determines its contribution to global cascades. The concept of subcritical path allows us to introduce a scalable algorithm for massively large-scale networks. Results in both synthetic random graphs and real networks show that the proposed method can achieve larger collective influence given the same number of seeds compared with other scalable heuristic approaches. PMID:28349988

  8. Efficient collective influence maximization in cascading processes with first-order transitions

    NASA Astrophysics Data System (ADS)

    Pei, Sen; Teng, Xian; Shaman, Jeffrey; Morone, Flaviano; Makse, Hernán A.

    2017-03-01

    In many social and biological networks, the collective dynamics of the entire system can be shaped by a small set of influential units through a global cascading process, manifested by an abrupt first-order transition in dynamical behaviors. Despite its importance in applications, efficient identification of multiple influential spreaders in cascading processes still remains a challenging task for large-scale networks. Here we address this issue by exploring the collective influence in general threshold models of cascading process. Our analysis reveals that the importance of spreaders is fixed by the subcritical paths along which cascades propagate: the number of subcritical paths attached to each spreader determines its contribution to global cascades. The concept of subcritical path allows us to introduce a scalable algorithm for massively large-scale networks. Results in both synthetic random graphs and real networks show that the proposed method can achieve larger collective influence given the same number of seeds compared with other scalable heuristic approaches.

  9. Transition metal-catalyzed oxidation of sulfur(IV) oxides. Atmospheric-relevant processes and mechanisms

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Brandt, C.; Eldik, R. van

    1995-01-01

    The transition metal-catalyzed oxidation of sulfur(IV) oxides has been known for more than 100 years. There is a significant lack of information on the actual role of the transition metal-catalyzed reactions, and much of the earlier work was performed without a detailed knowledge of the chemical system. For this reason attention is focused on the role of transition metal ions in the oxidation of sulfur(IV) oxides in terms of the coordination chemistry involved, as well as the stability and chemical behavior of the various participating species. The oxidation process of sulfur(IV) oxides plays an important role in atmospheric chemistry (e.g.more » acid rain formation) as well as industrial processes (e.g. desulfurization of plume gases and ore). The present report deals with the mechanism of the transition metal-catalyzed oxidation of sulfur(IV) oxides with the aim to discuss this in terms of atmospheric and chemical processes. In addition, the authors would like to emphasize the key role of oxygen in these processes. 1,076 refs.« less

  10. The Consolidation/Transition Model in Moral Reasoning Development.

    ERIC Educational Resources Information Center

    Walker, Lawrence J.; Gustafson, Paul; Hennig, Karl H.

    2001-01-01

    This longitudinal study with 62 children and adolescents examined the validity of the consolidation/transition model in the context of moral reasoning development. Results of standard statistical and Bayesian techniques supported the hypotheses regarding cyclical patterns of change and predictors of stage transition, and demonstrated the utility…

  11. Gender and Transition From Pediatric to Adult Health Care Among Youth With Acquired Brain Injury: Experiences in a Transition Model.

    PubMed

    Lindsay, Sally; Proulx, Meghann; Maxwell, Joanne; Hamdani, Yani; Bayley, Mark; Macarthur, Colin; Colantonio, Angela

    2016-02-01

    To explore gender and sex differences in experiences of transitioning to adult health care among young adults with acquired brain injury (ABI) who take part in a coordinated model of transitional care. Descriptive design using in-depth semistructured qualitative interviews. Interviews over the phone and in person. Participants (N=18) included 10 young adults with a diagnosis of ABI (4 women, 6 men; age range, 19-21y) and 9 parents (8 women, 1 man) from the Greater Toronto Area, Ontario, Canada. Not applicable. Semistructured interviews with participants. Our findings highlight several commonalities and differences relative to sex and gender among young adults with ABI who are transitioning from pediatric to adult care. Both young adult men and women experienced a similar transition process and similar organization, continuity, and availability of care. Sex differences were found in relational factors (eg, communication, family involvement, social support). Young adult men, and parents of the men, differed in their transition regarding relational factors (eg, communication, family involvement). Our findings show that young adult men and women with ABI who have taken part in a transition preparation program experience similarities in organization, continuity, and availability of care, but they experience differences in relational factors (eg, communication, family involvement). Copyright © 2016 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

  12. Modeling mechanical properties of a shear thickening fluid damper based on phase transition theory

    NASA Astrophysics Data System (ADS)

    Wei, Minghai; Lin, Kun; Guo, Qian

    2018-03-01

    Shear thickening fluids (STFs) are highly concentrated colloidal suspensions consisting of monodisperse nano-particles suspended in a carrying fluid, and have the capacity to display both flowable and rigid behaviors, when subjected to sudden stimuli. In that process, the external energy that acts on an STF can be dissipated quickly. The aim of this study is to present a dynamic model of a damper filled with STF that can be directly used in control engineering fields. To this end, shear stress during phase transition of the STF material is chosen as an internal variable. A non-convex function with bifurcation behavior is used to describe the phase transitioning of STF by determining the relationship between the behavioral characteristics of the microscopic phase and macroscopic damping force. This model is able to predict force-velocity and force-displacement relationships as functions of the loading frequency. Efficacy of the model is demonstrated via comparison with experimental results from previous studies. In addition, the results confirm the hypothesis regarding the occurrence of STF phase transitioning when subject to shear stress.

  13. State and transition models: Theory, applications, and challenges. In: Briske, D.D. Rangeland Systems: Processes, Management and Challenges

    USDA-ARS?s Scientific Manuscript database

    State and transition models (STMs) are used for communicating about ecosystem change in rangelands and other ecosystems, especially the implications for management. The fundamental premise that rangelands can exhibit multiple states is now widely accepted. The current application of STMs for managem...

  14. Random growth lattice filling model of percolation: a crossover from continuous to discontinuous transition

    NASA Astrophysics Data System (ADS)

    Roy, Bappaditya; Santra, S. B.

    2018-05-01

    A random growth lattice filling model of percolation with a touch and stop growth rule is developed and studied numerically on a two dimensional square lattice. Nucleation centers are continuously added one at a time to the empty lattice sites and clusters are grown from these nucleation centers with a growth probability g. For a given g (), the system passes through a critical point during the growth process where the transition from a disconnected to a connected phase occurs. The model is found to exhibit second order continuous percolation transitions as ordinary percolation for whereas for it exhibits weak first order discontinuous percolation transitions. The continuous transitions are characterized by estimating the values of the critical exponents associated with the order parameter fluctuation and the fractal dimension of the spanning cluster over the whole range of g. The discontinuous transitions, however, are characterized by a compact spanning cluster, lattice size independent fluctuation of the order parameter per lattice, departure from power law scaling in the cluster size distribution and weak bimodal distribution of the order parameter. The nature of transitions are further confirmed by studying the Binder cumulant. Instead of a sharp tricritical point, a tricritical region is found to occur for 0.5  <  g  <  0.8 within which the values of the critical exponents change continuously until the crossover from continuous to discontinuous transition is completed.

  15. Operationalizing resilience using state and transition models

    USDA-ARS?s Scientific Manuscript database

    In management, restoration, and policy contexts, the notion of resilience can be confusing. Systematic development of conceptual models of ecological state change (state transition models; STMs) can help overcome semantic confusion and promote a mechanistic understanding of resilience. Drawing on ex...

  16. Integrating continuous stocks and flows into state-and-transition simulation models of landscape change

    USGS Publications Warehouse

    Daniel, Colin J.; Sleeter, Benjamin M.; Frid, Leonardo; Fortin, Marie-Josée

    2018-01-01

    State-and-transition simulation models (STSMs) provide a general framework for forecasting landscape dynamics, including projections of both vegetation and land-use/land-cover (LULC) change. The STSM method divides a landscape into spatially-referenced cells and then simulates the state of each cell forward in time, as a discrete-time stochastic process using a Monte Carlo approach, in response to any number of possible transitions. A current limitation of the STSM method, however, is that all of the state variables must be discrete.Here we present a new approach for extending a STSM, in order to account for continuous state variables, called a state-and-transition simulation model with stocks and flows (STSM-SF). The STSM-SF method allows for any number of continuous stocks to be defined for every spatial cell in the STSM, along with a suite of continuous flows specifying the rates at which stock levels change over time. The change in the level of each stock is then simulated forward in time, for each spatial cell, as a discrete-time stochastic process. The method differs from the traditional systems dynamics approach to stock-flow modelling in that the stocks and flows can be spatially-explicit, and the flows can be expressed as a function of the STSM states and transitions.We demonstrate the STSM-SF method by integrating a spatially-explicit carbon (C) budget model with a STSM of LULC change for the state of Hawai'i, USA. In this example, continuous stocks are pools of terrestrial C, while the flows are the possible fluxes of C between these pools. Importantly, several of these C fluxes are triggered by corresponding LULC transitions in the STSM. Model outputs include changes in the spatial and temporal distribution of C pools and fluxes across the landscape in response to projected future changes in LULC over the next 50 years.The new STSM-SF method allows both discrete and continuous state variables to be integrated into a STSM, including interactions between

  17. Two-Dimensional Wetting Transition Modeling with the Potts Model

    NASA Astrophysics Data System (ADS)

    Lopes, Daisiane M.; Mombach, José C. M.

    2017-12-01

    A droplet of a liquid deposited on a surface structured in pillars may have two states of wetting: (1) Cassie-Baxter (CB), the liquid remains on top of the pillars, also known as heterogeneous wetting, or (2) Wenzel, the liquid fills completely the cavities of the surface, also known as homogeneous wetting. Studies show that between these two states, there is an energy barrier that, when overcome, results in the transition of states. The transition can be achieved by changes in geometry parameters of the surface, by vibrations of the surface or by evaporation of the liquid. In this paper, we present a comparison of two-dimensional simulations of the Cassie-Wenzel transition on pillar-structured surfaces using the cellular Potts model (CPM) with studies performed by Shahraz et al. In our work, we determine a transition diagram by varying the surface parameters such as the interpillar distance ( G) and the pillar height ( H). Our results were compared to those obtained by Shahraz et al. obtaining good agreement.

  18. Modeling the polydomain-monodomain transition of liquid crystal elastomers.

    PubMed

    Whitmer, Jonathan K; Roberts, Tyler F; Shekhar, Raj; Abbott, Nicholas L; de Pablo, Juan J

    2013-02-01

    We study the mechanism of the polydomain-monodomain transition in liquid crystalline elastomers at the molecular scale. A coarse-grained model is proposed in which mesogens are described as ellipsoidal particles. Molecular dynamics simulations are used to examine the transition from a polydomain state to a monodomain state in the presence of uniaxial strain. Our model demonstrates soft elasticity, similar to that exhibited by side-chain elastomers in the literature. By analyzing the growth dynamics of nematic domains during uniaxial extension, we provide direct evidence that at a molecular level the polydomain-monodomain transition proceeds through cluster rotation and domain growth.

  19. Single-Column Model Simulations of Subtropical Marine Boundary-Layer Cloud Transitions Under Weakening Inversions

    NASA Astrophysics Data System (ADS)

    Neggers, R. A. J.; Ackerman, A. S.; Angevine, W. M.; Bazile, E.; Beau, I.; Blossey, P. N.; Boutle, I. A.; de Bruijn, C.; Cheng, A.; van der Dussen, J.; Fletcher, J.; Dal Gesso, S.; Jam, A.; Kawai, H.; Cheedela, S. K.; Larson, V. E.; Lefebvre, M.-P.; Lock, A. P.; Meyer, N. R.; de Roode, S. R.; de Rooy, W.; Sandu, I.; Xiao, H.; Xu, K.-M.

    2017-10-01

    Results are presented of the GASS/EUCLIPSE single-column model intercomparison study on the subtropical marine low-level cloud transition. A central goal is to establish the performance of state-of-the-art boundary-layer schemes for weather and climate models for this cloud regime, using large-eddy simulations of the same scenes as a reference. A novelty is that the comparison covers four different cases instead of one, in order to broaden the covered parameter space. Three cases are situated in the North-Eastern Pacific, while one reflects conditions in the North-Eastern Atlantic. A set of variables is considered that reflects key aspects of the transition process, making use of simple metrics to establish the model performance. Using this method, some longstanding problems in low-level cloud representation are identified. Considerable spread exists among models concerning the cloud amount, its vertical structure, and the associated impact on radiative transfer. The sign and amplitude of these biases differ somewhat per case, depending on how far the transition has progressed. After cloud breakup the ensemble median exhibits the well-known "too few too bright" problem. The boundary-layer deepening rate and its state of decoupling are both underestimated, while the representation of the thin capping cloud layer appears complicated by a lack of vertical resolution. Encouragingly, some models are successful in representing the full set of variables, in particular, the vertical structure and diurnal cycle of the cloud layer in transition. An intriguing result is that the median of the model ensemble performs best, inspiring a new approach in subgrid parameterization.

  20. Learning through Transitions: The Role of Institutions

    ERIC Educational Resources Information Center

    Zittoun, Tania

    2008-01-01

    In this paper two models are proposed for analysing transitions in education. Firstly, transitions are the processes that follow ruptures perceived by people. They include learning, identity change, and meaning making processes. Secondly, processes of change are observed through a semiotic prism, articulating self-other-object-sense of the object…

  1. A stochastic hybrid systems based framework for modeling dependent failure processes

    PubMed Central

    Fan, Mengfei; Zeng, Zhiguo; Zio, Enrico; Kang, Rui; Chen, Ying

    2017-01-01

    In this paper, we develop a framework to model and analyze systems that are subject to dependent, competing degradation processes and random shocks. The degradation processes are described by stochastic differential equations, whereas transitions between the system discrete states are triggered by random shocks. The modeling is, then, based on Stochastic Hybrid Systems (SHS), whose state space is comprised of a continuous state determined by stochastic differential equations and a discrete state driven by stochastic transitions and reset maps. A set of differential equations are derived to characterize the conditional moments of the state variables. System reliability and its lower bounds are estimated from these conditional moments, using the First Order Second Moment (FOSM) method and Markov inequality, respectively. The developed framework is applied to model three dependent failure processes from literature and a comparison is made to Monte Carlo simulations. The results demonstrate that the developed framework is able to yield an accurate estimation of reliability with less computational costs compared to traditional Monte Carlo-based methods. PMID:28231313

  2. A stochastic hybrid systems based framework for modeling dependent failure processes.

    PubMed

    Fan, Mengfei; Zeng, Zhiguo; Zio, Enrico; Kang, Rui; Chen, Ying

    2017-01-01

    In this paper, we develop a framework to model and analyze systems that are subject to dependent, competing degradation processes and random shocks. The degradation processes are described by stochastic differential equations, whereas transitions between the system discrete states are triggered by random shocks. The modeling is, then, based on Stochastic Hybrid Systems (SHS), whose state space is comprised of a continuous state determined by stochastic differential equations and a discrete state driven by stochastic transitions and reset maps. A set of differential equations are derived to characterize the conditional moments of the state variables. System reliability and its lower bounds are estimated from these conditional moments, using the First Order Second Moment (FOSM) method and Markov inequality, respectively. The developed framework is applied to model three dependent failure processes from literature and a comparison is made to Monte Carlo simulations. The results demonstrate that the developed framework is able to yield an accurate estimation of reliability with less computational costs compared to traditional Monte Carlo-based methods.

  3. Modeling continuum of epithelial mesenchymal transition plasticity.

    PubMed

    Mandal, Mousumi; Ghosh, Biswajoy; Anura, Anji; Mitra, Pabitra; Pathak, Tanmaya; Chatterjee, Jyotirmoy

    2016-02-01

    Living systems respond to ambient pathophysiological changes by altering their phenotype, a phenomenon called 'phenotypic plasticity'. This program contains information about adaptive biological dynamism. Epithelial-mesenchymal transition (EMT) is one such process found to be crucial in development, wound healing, and cancer wherein the epithelial cells with restricted migratory potential develop motile functions by acquiring mesenchymal characteristics. In the present study, phase contrast microscopy images of EMT induced HaCaT cells were acquired at 24 h intervals for 96 h. The expression study of relevant pivotal molecules viz. F-actin, vimentin, fibronectin and N-cadherin was carried out to confirm the EMT process. Cells were intuitively categorized into five distinct morphological phenotypes. A population of 500 cells for each temporal point was selected to quantify their frequency of occurrence. The plastic interplay of cell phenotypes from the observations was described as a Markovian process. A model was formulated empirically using simple linear algebra, to depict the possible mechanisms of cellular transformation among the five phenotypes. This work employed qualitative, semi-quantitative and quantitative tools towards illustration and establishment of the EMT continuum. Thus, it provides a newer perspective to understand the embedded plasticity across the EMT spectrum.

  4. Simple model of inhibition of chain-branching combustion processes

    NASA Astrophysics Data System (ADS)

    Babushok, Valeri I.; Gubernov, Vladimir V.; Minaev, Sergei S.; Miroshnichenko, Taisia P.

    2017-11-01

    A simple kinetic model has been suggested to describe the inhibition and extinction of flame propagation in reaction systems with chain-branching reactions typical for hydrocarbon systems. The model is based on the generalised model of the combustion process with chain-branching reaction combined with the one-stage reaction describing the thermal mode of flame propagation with the addition of inhibition reaction steps. Inhibitor addition suppresses the radical overshoot in flame and leads to the change of reaction mode from the chain-branching reaction to a thermal mode of flame propagation. With the increase of inhibitor the transition of chain-branching mode of reaction to the reaction with straight-chains (non-branching chain reaction) is observed. The inhibition part of the model includes a block of three reactions to describe the influence of the inhibitor. The heat losses are incorporated into the model via Newton cooling. The flame extinction is the result of the decreased heat release of inhibited reaction processes and the suppression of radical overshoot with the further decrease of the reaction rate due to the temperature decrease and mixture dilution. A comparison of the results of modelling laminar premixed methane/air flames inhibited by potassium bicarbonate (gas phase model, detailed kinetic model) with the results obtained using the suggested simple model is presented. The calculations with the detailed kinetic model demonstrate the following modes of combustion process: (1) flame propagation with chain-branching reaction (with radical overshoot, inhibitor addition decreases the radical overshoot down to the equilibrium level); (2) saturation of chemical influence of inhibitor, and (3) transition to thermal mode of flame propagation (non-branching chain mode of reaction). The suggested simple kinetic model qualitatively reproduces the modes of flame propagation with the addition of the inhibitor observed using detailed kinetic models.

  5. Testing a Theoretical Model of Immigration Transition and Physical Activity.

    PubMed

    Chang, Sun Ju; Im, Eun-Ok

    2015-01-01

    The purposes of the study were to develop a theoretical model to explain the relationships between immigration transition and midlife women's physical activity and test the relationships among the major variables of the model. A theoretical model, which was developed based on transitions theory and the midlife women's attitudes toward physical activity theory, consists of 4 major variables, including length of stay in the United States, country of birth, level of acculturation, and midlife women's physical activity. To test the theoretical model, a secondary analysis with data from 127 Hispanic women and 123 non-Hispanic (NH) Asian women in a national Internet study was used. Among the major variables of the model, length of stay in the United States was negatively associated with physical activity in Hispanic women. Level of acculturation in NH Asian women was positively correlated with women's physical activity. Country of birth and level of acculturation were significant factors that influenced physical activity in both Hispanic and NH Asian women. The findings support the theoretical model that was developed to examine relationships between immigration transition and physical activity; it shows that immigration transition can play an essential role in influencing health behaviors of immigrant populations in the United States. The NH theoretical model can be widely used in nursing practice and research that focus on immigrant women and their health behaviors. Health care providers need to consider the influences of immigration transition to promote immigrant women's physical activity.

  6. Large-scale evaluation of β -decay rates of r -process nuclei with the inclusion of first-forbidden transitions

    NASA Astrophysics Data System (ADS)

    Marketin, T.; Huther, L.; Martínez-Pinedo, G.

    2016-02-01

    Background: r -process nucleosynthesis models rely, by necessity, on nuclear structure models for input. Particularly important are β -decay half-lives of neutron-rich nuclei. At present only a single systematic calculation exists that provides values for all relevant nuclei making it difficult to test the sensitivity of nucleosynthesis models to this input. Additionally, even though there are indications that their contribution may be significant, the impact of first-forbidden transitions on decay rates has not been systematically studied within a consistent model. Purpose: Our goal is to provide a table of β -decay half-lives and β -delayed neutron emission probabilities, including first-forbidden transitions, calculated within a fully self-consistent microscopic theoretical framework. The results are used in an r -process nucleosynthesis calculation to asses the sensitivity of heavy element nucleosynthesis to weak interaction reaction rates. Method: We use a fully self-consistent covariant density functional theory (CDFT) framework. The ground state of all nuclei is calculated with the relativistic Hartree-Bogoliubov (RHB) model, and excited states are obtained within the proton-neutron relativistic quasiparticle random phase approximation (p n -RQRPA). Results: The β -decay half-lives, β -delayed neutron emission probabilities, and the average number of emitted neutrons have been calculated for 5409 nuclei in the neutron-rich region of the nuclear chart. We observe a significant contribution of the first-forbidden transitions to the total decay rate in nuclei far from the valley of stability. The experimental half-lives are in general well reproduced for even-even, odd-A , and odd-odd nuclei, in particular for short-lived nuclei. The resulting data table is included with the article as Supplemental Material. Conclusions: In certain regions of the nuclear chart, first-forbidden transitions constitute a large fraction of the total decay rate and must be

  7. Phase Transition Behavior in a Neutral Evolution Model

    NASA Astrophysics Data System (ADS)

    King, Dawn; Scott, Adam; Maric, Nevena; Bahar, Sonya

    2014-03-01

    The complexity of interactions among individuals and between individuals and the environment make agent based modeling ideal for studying emergent speciation. This is a dynamically complex problem that can be characterized via the critical behavior of a continuous phase transition. Concomitant with the main tenets of natural selection, we allow organisms to reproduce, mutate, and die within a neutral phenotype space. Previous work has shown phase transition behavior in an assortative mating model with variable fitness landscapes as the maximum mutation size (μ) was varied (Dees and Bahar, 2010). Similarly, this behavior was recently presented in the work of Scott et al. (2013), even on a completely neutral landscape, for bacterial-like fission as well as for assortative mating. Here we present another neutral model to investigate the `critical' phase transition behavior of three mating types - assortative, bacterial, and random - in a phenotype space as a function of the percentage of random death. Results show two types of phase transitions occurring for the parameters of the population size and the number of clusters (an analogue of species), indicating different evolutionary dynamics for system survival and clustering. This research was supported by funding from: University of Missouri Research Board and James S. McDonnell Foundation.

  8. Calibration of state and transition models with FVS

    Treesearch

    Melinda Moeur; Don Vandendriesche

    2010-01-01

    The Interagency Mapping and Assessment Project (IMAP), a partnership between federal and state agencies, is developing mid-scale vegetation data and state and transition models (STM) for comparing the likely outcomes of alternative management policies on forested landscapes across the Pacific Northwest Region. In an STM, acres within a forested ecosystem transition...

  9. Dicke-model simulation via cavity-assisted Raman transitions

    NASA Astrophysics Data System (ADS)

    Zhang, Zhiqiang; Lee, Chern Hui; Kumar, Ravi; Arnold, K. J.; Masson, Stuart J.; Grimsmo, A. L.; Parkins, A. S.; Barrett, M. D.

    2018-04-01

    The Dicke model is of fundamental importance in quantum mechanics for understanding the collective behavior of atoms coupled to a single electromagnetic mode. Here, we demonstrate a Dicke-model simulation via cavity-assisted Raman transitions in a configuration using counterpropagating laser beams. The observations indicate that motional effects should be included to fully account for the results. These results are contrary to experiments using single-beam and copropagating configurations. We give a theoretical description that accounts for the beam geometries used in the experiments and indicates the potential role of motional effects. In particular, a model is given that highlights the influence of Doppler broadening on the observed phase-transition thresholds.

  10. Apparent Transition Behavior of Widely-Used Turbulence Models

    NASA Technical Reports Server (NTRS)

    Rumsey, Christopher L.

    2006-01-01

    The Spalart-Allmaras and the Menter SST kappa-omega turbulence models are shown to have the undesirable characteristic that, for fully turbulent computations, a transition region can occur whose extent varies with grid density. Extremely fine two-dimensional grids over the front portion of an airfoil are used to demonstrate the effect. As the grid density is increased, the laminar region near the nose becomes larger. In the Spalart-Allmaras model this behavior is due to convergence to a laminar-behavior fixed point that occurs in practice when freestream turbulence is below some threshold. It is the result of a feature purposefully added to the original model in conjunction with a special trip function. This degenerate fixed point can also cause nonuniqueness regarding where transition initiates on a given grid. Consistent fully turbulent results can easily be achieved by either using a higher freestream turbulence level or by making a simple change to one of the model constants. Two-equation kappa-omega models, including the SST model, exhibit strong sensitivity to numerical resolution near the area where turbulence initiates. Thus, inconsistent apparent transition behavior with grid refinement in this case does not appear to stem from the presence of a degenerate fixed point. Rather, it is a fundamental property of the kappa-omega model itself, and is not easily remedied.

  11. Apparent Transition Behavior of Widely-Used Turbulence Models

    NASA Technical Reports Server (NTRS)

    Rumsey, Christopher L.

    2007-01-01

    The Spalart-Allmaras and the Menter SST k-omega turbulence models are shown to have the undesirable characteristic that, for fully turbulent computations, a transition region can occur whose extent varies with grid density. Extremely fine two-dimensional grids over the front portion of an airfoil are used to demonstrate the effect. As the grid density is increased, the laminar region near the nose becomes larger. In the Spalart-Allmaras model this behavior is due to convergence to a laminar-behavior fixed point that occurs in practice when freestream turbulence is below some threshold. It is the result of a feature purposefully added to the original model in conjunction with a special trip function. This degenerate fixed point can also cause non-uniqueness regarding where transition initiates on a given grid. Consistent fully turbulent results can easily be achieved by either using a higher freestream turbulence level or by making a simple change to one of the model constants. Two-equation k-omega models, including the SST model, exhibit strong sensitivity to numerical resolution near the area where turbulence initiates. Thus, inconsistent apparent transition behavior with grid refinement in this case does not appear to stem from the presence of a degenerate fixed point. Rather, it is a fundamental property of the k-omega model itself, and is not easily remedied.

  12. Modeling of the heat transfer in bypass transitional boundary-layer flows

    NASA Technical Reports Server (NTRS)

    Simon, Frederick F.; Stephens, Craig A.

    1991-01-01

    A low Reynolds number k-epsilon turbulence model and conditioned momentum, energy and turbulence equations were used to predict bypass transition heat transfer on a flat plate in a high-disturbance environment with zero pressure gradient. The use of conditioned equations was demonstrated to be an improvement over the use of the global-time-averaged equations for the calculation of velocity profiles and turbulence intensity profiles in the transition region of a boundary layer. The approach of conditioned equations is extended to include heat transfer and a modeling of transition events is used to predict transition onset and the extent of transition on a flat plate. The events, which describe the boundary layer at the leading edge, result in boundary-layer regions consisting of: (1) the laminar, (2) pseudolaminar, (3) transitional, and (4) turbulent boundary layers. The modeled transition events were incorporated into the TEXSTAN 2-D boundary-layer code which is used to numerically predict the heat transfer. The numerical predictions in general compared well with the experimental data and revealed areas where additional experimental information is needed.

  13. Research activities at the Center for Modeling of Turbulence and Transition

    NASA Technical Reports Server (NTRS)

    Shih, Tsan-Hsing

    1993-01-01

    The main research activities at the Center for Modeling of Turbulence and Transition (CMOTT) are described. The research objective of CMOTT is to improve and/or develop turbulence and transition models for propulsion systems. The flows of interest in propulsion systems can be both compressible and incompressible, three dimensional, bounded by complex wall geometries, chemically reacting, and involve 'bypass' transition. The most relevant turbulence and transition models for the above flows are one- and two-equation eddy viscosity models, Reynolds stress algebraic- and transport-equation models, pdf models, and multiple-scale models. All these models are classified as one-point closure schemes since only one-point (in time and space) turbulent correlations, such as second moments (Reynolds stresses and turbulent heat fluxes) and third moments, are involved. In computational fluid dynamics, all turbulent quantities are one-point correlations. Therefore, the study of one-point turbulent closure schemes is the focus of our turbulence research. However, other research, such as the renormalization group theory, the direct interaction approximation method, and numerical simulations are also pursued to support the development of turbulence modeling.

  14. Comparative empirical analysis of flow-weighted transit route networks in R-space and evolution modeling

    NASA Astrophysics Data System (ADS)

    Huang, Ailing; Zang, Guangzhi; He, Zhengbing; Guan, Wei

    2017-05-01

    Urban public transit system is a typical mixed complex network with dynamic flow, and its evolution should be a process coupling topological structure with flow dynamics, which has received little attention. This paper presents the R-space to make a comparative empirical analysis on Beijing’s flow-weighted transit route network (TRN) and we found that both the Beijing’s TRNs in the year of 2011 and 2015 exhibit the scale-free properties. As such, we propose an evolution model driven by flow to simulate the development of TRNs with consideration of the passengers’ dynamical behaviors triggered by topological change. The model simulates that the evolution of TRN is an iterative process. At each time step, a certain number of new routes are generated driven by travel demands, which leads to dynamical evolution of new routes’ flow and triggers perturbation in nearby routes that will further impact the next round of opening new routes. We present the theoretical analysis based on the mean-field theory, as well as the numerical simulation for this model. The results obtained agree well with our empirical analysis results, which indicate that our model can simulate the TRN evolution with scale-free properties for distributions of node’s strength and degree. The purpose of this paper is to illustrate the global evolutional mechanism of transit network that will be used to exploit planning and design strategies for real TRNs.

  15. Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, part II: extension to describe performance of solid dosage forms.

    PubMed

    Thelen, Kirstin; Coboeken, Katrin; Willmann, Stefan; Dressman, Jennifer B; Lippert, Jörg

    2012-03-01

    The physiological absorption model presented in part I of this work is now extended to account for dosage-form-dependent gastrointestinal (GI) transit as well as disintegration and dissolution processes of various immediate-release and modified-release dosage forms. Empirical functions of the Weibull type were fitted to experimental in vitro dissolution profiles of solid dosage forms for eight test compounds (aciclovir, caffeine, cimetidine, diclofenac, furosemide, paracetamol, phenobarbital, and theophylline). The Weibull functions were then implemented into the model to predict mean plasma concentration-time profiles of the various dosage forms. On the basis of these dissolution functions, pharmacokinetics (PK) of six model drugs was predicted well. In the case of diclofenac, deviations between predicted and observed plasma concentrations were attributable to the large variability in gastric emptying time of the enteric-coated tablets. Likewise, oral PK of furosemide was found to be predominantly governed by the gastric emptying patterns. It is concluded that the revised model for GI transit and absorption was successfully integrated with dissolution functions of the Weibull type, enabling prediction of in vivo PK profiles from in vitro dissolution data. It facilitates a comparative analysis of the parameters contributing to oral drug absorption and is thus a powerful tool for formulation design. Copyright © 2011 Wiley Periodicals, Inc.

  16. Integrating land management into Earth system models: the importance of land use transitions at sub-grid-scale

    NASA Astrophysics Data System (ADS)

    Pongratz, Julia; Wilkenskjeld, Stiig; Kloster, Silvia; Reick, Christian

    2014-05-01

    Recent studies indicate that changes in surface climate and carbon fluxes caused by land management (i.e., modifications of vegetation structure without changing the type of land cover) can be as large as those caused by land cover change. Further, such effects may occur on substantial areas: while about one quarter of the land surface has undergone land cover change, another fifty percent are managed. This calls for integration of management processes in Earth system models (ESMs). This integration increases the importance of awareness and agreement on how to diagnose effects of land use in ESMs to avoid additional model spread and thus unnecessary uncertainties in carbon budget estimates. Process understanding of management effects, their model implementation, as well as data availability on management type and extent pose challenges. In this respect, a significant step forward has been done in the framework of the current IPCC's CMIP5 simulations (Coupled Model Intercomparison Project Phase 5): The climate simulations were driven with the same harmonized land use dataset that, different from most datasets commonly used before, included information on two important types of management: wood harvest and shifting cultivation. However, these new aspects were employed by only part of the CMIP5 models, while most models continued to use the associated land cover maps. Here, we explore the consequences for the carbon cycle of including subgrid-scale land transformations ("gross transitions"), such as shifting cultivation, as example of the current state of implementation of land management in ESMs. Accounting for gross transitions is expected to increase land use emissions because it represents simultaneous clearing and regrowth of natural vegetation in different parts of the grid cell, reducing standing carbon stocks. This process cannot be captured by prescribing land cover maps ("net transitions"). Using the MPI-ESM we find that ignoring gross transitions

  17. Transitioning GONG data processing to NOAA SWPC operations

    NASA Astrophysics Data System (ADS)

    Reinard, A.; Marble, A.; Hill, F.; Berger, T. E.

    2015-12-01

    The NOAA Space Weather Prediction Center (SWPC) is the nation's official source of space weather watches, warnings, and alerts, providing 24x7 forecasting and support to critical infrastructure operators around the world. Observations of the conditions on the Sun are crucial for determining when and if a warning is needed. The Global Oscillation Network Group (GONG) operated by the National Solar Observatory (NSO) consists of six ground stations, allowing continuous observations of the Sun. Of particular interest for space weather purposes are the H-alpha images and magnetograms. The H-alpha data are used to identify filaments and their eruptions, to assess active region evolution and plage extent, and to help localize flare locations. The magnetograms are used to identify neutral lines, to examine potential shearing areas and to characterize the magnetic structure of active regions. GONG magnetograms also provide the initial condition for models of solar wind expansion through the heliosphere such as the WSA-Enlil model. Although beyond the scope of current space weather applications, GONG helioseismology products can be used to assess active region emergence on the far side of the Sun and to indicate the flaring potential of a front-side active region. These products are being examined as future tools in flare prediction. NSO has operated GONG as a science facility since 1995 and has provided processed space weather data products to NOAA via public internet connections for the past several years. In 2014 the White House Office of Management and Budget (OMB) requested that NOAA transition the GONG network to an operational space weather asset in order to ensure the continued flow of critical magnetogram data for solar wind models. NSO will continue to operate and manage the instruments and sites, but the H-alpha images and 10 minute averaged magnetogram data will be sent directly to SWPC for processing and use in space weather modeling. SWPC will make these data

  18. Transitioning GONG data processing to NOAA SWPC operations

    NASA Astrophysics Data System (ADS)

    Reinard, Alysha; Marble, Andrew R.; Berger, Thomas

    2016-05-01

    The NOAA Space Weather Prediction Center (SWPC) is the nation's official source of space weather watches, warnings, and alerts, providing 24x7 forecasting and support to critical infrastructure operators around the world. Observations of the conditions on the Sun are crucial for determining when and if a warning is needed. The Global Oscillation Network Group (GONG) operated by the National Solar Observatory (NSO) consists of six ground stations, allowing continuous observations of the Sun. Of particular interest for space weather purposes are the H-alpha images and magnetograms. The H-alpha data are used to identify filaments and their eruptions, to assess active region evolution and plage extent, and to help localize flare locations. The magnetograms are used to identify neutral lines, to examine potential shearing areas and to characterize the magnetic structure of active regions. GONG magnetograms also provide the initial condition for models of solar wind expansion through the heliosphere such as the WSA-Enlil model. Although beyond the scope of current space weather applications, GONG helioseismology products can be used to assess active region emergence on the far side of the Sun and to indicate the flaring potential of a front-side active region. These products are being examined as future tools in flare prediction.NSO has operated GONG as a science facility since 1995 and has provided processed space weather data products to NOAA via for the past several years. In 2014 the White House Office of Management and Budget (OMB) requested that NOAA transition the GONG network to an operational space weather asset in order to ensure the continued flow of critical data for solar wind models. NSO will continue to operate and manage the instruments and sites, but the H-alpha images and 10 minute averaged magnetogram data will be sent directly to SWPC for processing and use in space weather modeling. SWPC will make these data available to NSO and the public via the

  19. Computational Modeling For The Transitional Flow Over A Multi-Element Airfoil

    NASA Technical Reports Server (NTRS)

    Liou, William W.; Liu, Feng-Jun; Rumsey, Chris L. (Technical Monitor)

    2000-01-01

    The transitional flow over a multi-element airfoil in a landing configuration are computed using a two equation transition model. The transition model is predictive in the sense that the transition onset is a result of the calculation and no prior knowledge of the transition location is required. The computations were performed using the INS2D) Navier-Stokes code. Overset grids are used for the three-element airfoil. The airfoil operating conditions are varied for a range of angle of attack and for two different Reynolds numbers of 5 million and 9 million. The computed results are compared with experimental data for the surface pressure, skin friction, transition onset location, and velocity magnitude. In general, the comparison shows a good agreement with the experimental data.

  20. The remarkable ability of turbulence model equations to describe transition

    NASA Technical Reports Server (NTRS)

    Wilcox, David C.

    1992-01-01

    This paper demonstrates how well the k-omega turbulence model describes the nonlinear growth of flow instabilities from laminar flow into the turbulent flow regime. Viscous modifications are proposed for the k-omega model that yield close agreement with measurements and with Direct Numerical Simulation results for channel and pipe flow. These modifications permit prediction of subtle sublayer details such as maximum dissipation at the surface, k approximately y(exp 2) as y approaches 0, and the sharp peak value of k near the surface. With two transition specific closure coefficients, the model equations accurately predict transition for an incompressible flat-plate boundary layer. The analysis also shows why the k-epsilon model is so difficult to use for predicting transition.

  1. Model-independent Exoplanet Transit Spectroscopy

    NASA Astrophysics Data System (ADS)

    Aronson, Erik; Piskunov, Nikolai

    2018-05-01

    We propose a new data analysis method for obtaining transmission spectra of exoplanet atmospheres and brightness variation across the stellar disk from transit observations. The new method is capable of recovering exoplanet atmosphere absorption spectra and stellar specific intensities without relying on theoretical models of stars and planets. We simultaneously fit both stellar specific intensity and planetary radius directly to transit light curves. This allows stellar models to be removed from the data analysis. Furthermore, we use a data quality weighted filtering technique to achieve an optimal trade-off between spectral resolution and reconstruction fidelity homogenizing the signal-to-noise ratio across the wavelength range. Such an approach is more efficient than conventional data binning onto a low-resolution wavelength grid. We demonstrate that our analysis is capable of reproducing results achieved by using an explicit quadratic limb-darkening equation and that the filtering technique helps eliminate spurious spectral features in regions with strong telluric absorption. The method is applied to the VLT FORS2 observations of the exoplanets GJ 1214 b and WASP-49 b, and our results are in agreement with previous studies. Comparisons between obtained stellar specific intensity and numerical models indicates that the method is capable of accurately reconstructing the specific intensity. The proposed method enables more robust characterization of exoplanetary atmospheres by separating derivation of planetary transmission and stellar specific intensity spectra (that is model-independent) from chemical and physical interpretation.

  2. The transition probability and the probability for the left-most particle's position of the q-totally asymmetric zero range process

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Korhonen, Marko; Lee, Eunghyun

    2014-01-15

    We treat the N-particle zero range process whose jumping rates satisfy a certain condition. This condition is required to use the Bethe ansatz and the resulting model is the q-boson model by Sasamoto and Wadati [“Exact results for one-dimensional totally asymmetric diffusion models,” J. Phys. A 31, 6057–6071 (1998)] or the q-totally asymmetric zero range process (TAZRP) by Borodin and Corwin [“Macdonald processes,” Probab. Theory Relat. Fields (to be published)]. We find the explicit formula of the transition probability of the q-TAZRP via the Bethe ansatz. By using the transition probability we find the probability distribution of the left-most particle'smore » position at time t. To find the probability for the left-most particle's position we find a new identity corresponding to identity for the asymmetric simple exclusion process by Tracy and Widom [“Integral formulas for the asymmetric simple exclusion process,” Commun. Math. Phys. 279, 815–844 (2008)]. For the initial state that all particles occupy a single site, the probability distribution of the left-most particle's position at time t is represented by the contour integral of a determinant.« less

  3. Recognition of human activity characteristics based on state transitions modeling technique

    NASA Astrophysics Data System (ADS)

    Elangovan, Vinayak; Shirkhodaie, Amir

    2012-06-01

    Human Activity Discovery & Recognition (HADR) is a complex, diverse and challenging task but yet an active area of ongoing research in the Department of Defense. By detecting, tracking, and characterizing cohesive Human interactional activity patterns, potential threats can be identified which can significantly improve situation awareness, particularly, in Persistent Surveillance Systems (PSS). Understanding the nature of such dynamic activities, inevitably involves interpretation of a collection of spatiotemporally correlated activities with respect to a known context. In this paper, we present a State Transition model for recognizing the characteristics of human activities with a link to a prior contextbased ontology. Modeling the state transitions between successive evidential events determines the activities' temperament. The proposed state transition model poses six categories of state transitions including: Human state transitions of Object handling, Visibility, Entity-entity relation, Human Postures, Human Kinematics and Distance to Target. The proposed state transition model generates semantic annotations describing the human interactional activities via a technique called Casual Event State Inference (CESI). The proposed approach uses a low cost kinect depth camera for indoor and normal optical camera for outdoor monitoring activities. Experimental results are presented here to demonstrate the effectiveness and efficiency of the proposed technique.

  4. Transition mixing study empirical model report

    NASA Technical Reports Server (NTRS)

    Srinivasan, R.; White, C.

    1988-01-01

    The empirical model developed in the NASA Dilution Jet Mixing Program has been extended to include the curvature effects of transition liners. This extension is based on the results of a 3-D numerical model generated under this contract. The empirical model results agree well with the numerical model results for all tests cases evaluated. The empirical model shows faster mixing rates compared to the numerical model. Both models show drift of jets toward the inner wall of a turning duct. The structure of the jets from the inner wall does not exhibit the familiar kidney-shaped structures observed for the outer wall jets or for jets injected in rectangular ducts.

  5. Process, outcome and experience of transition from child to adult mental healthcare: multiperspective study.

    PubMed

    Singh, Swaran P; Paul, Moli; Ford, Tamsin; Kramer, Tami; Weaver, Tim; McLaren, Susan; Hovish, Kimberly; Islam, Zoebia; Belling, Ruth; White, Sarah

    2010-10-01

    Many adolescents with mental health problems experience transition of care from child and adolescent mental health services (CAMHS) to adult mental health services (AMHS). As part of the TRACK study we evaluated the process, outcomes and user and carer experience of transition from CAMHS to AMHS. We identified a cohort of service users crossing the CAMHS/AMHS boundary over 1 year across six mental health trusts in England. We tracked their journey to determine predictors of optimal transition and conducted qualitative interviews with a subsample of users, their carers and clinicians on how transition was experienced. Of 154 individuals who crossed the transition boundary in 1 year, 90 were actual referrals (i.e. they made a transition to AMHS), and 64 were potential referrals (i.e. were either not referred to AMHS or not accepted by AMHS). Individuals with a history of severe mental illness, being on medication or having been admitted were more likely to make a transition than those with neurodevelopmental disorders, emotional/neurotic disorders and emerging personality disorder. Optimal transition, defined as adequate transition planning, good information transfer across teams, joint working between teams and continuity of care following transition, was experienced by less than 5% of those who made a transition. Following transition, most service users stayed engaged with AMHS and reported improvement in their mental health. For the vast majority of service users, transition from CAMHS to AMHS is poorly planned, poorly executed and poorly experienced. The transition process accentuates pre-existing barriers between CAMHS and AMHS.

  6. Curricular Implications of Transition: Life Skills Instruction as an Integral Part of Transition Education.

    ERIC Educational Resources Information Center

    Patton, James R.; Cronin, Mary E.; Jairrels, Veda

    1997-01-01

    Discusses life skills instruction in the transition education of adolescents with disabilities. The relationship of life skills instruction to the transition process, curricular issues related to students with special needs, models for teaching life skills, options for covering life skills in the curriculum, and cultural considerations are…

  7. Bifurcation analysis and dimension reduction of a predator-prey model for the L-H transition

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Dam, Magnus; Brøns, Morten; Juul Rasmussen, Jens

    2013-10-15

    The L-H transition denotes a shift to an improved confinement state of a toroidal plasma in a fusion reactor. A model of the L-H transition is required to simulate the time dependence of tokamak discharges that include the L-H transition. A 3-ODE predator-prey type model of the L-H transition is investigated with bifurcation theory of dynamical systems. The analysis shows that the model contains three types of transitions: an oscillating transition, a sharp transition with hysteresis, and a smooth transition. The model is recognized as a slow-fast system. A reduced 2-ODE model consisting of the full model restricted to themore » flow on the critical manifold is found to contain all the same dynamics as the full model. This means that all the dynamics in the system is essentially 2-dimensional, and a minimal model of the L-H transition could be a 2-ODE model.« less

  8. Relativistic diffusion processes and random walk models

    NASA Astrophysics Data System (ADS)

    Dunkel, Jörn; Talkner, Peter; Hänggi, Peter

    2007-02-01

    The nonrelativistic standard model for a continuous, one-parameter diffusion process in position space is the Wiener process. As is well known, the Gaussian transition probability density function (PDF) of this process is in conflict with special relativity, as it permits particles to propagate faster than the speed of light. A frequently considered alternative is provided by the telegraph equation, whose solutions avoid superluminal propagation speeds but suffer from singular (noncontinuous) diffusion fronts on the light cone, which are unlikely to exist for massive particles. It is therefore advisable to explore other alternatives as well. In this paper, a generalized Wiener process is proposed that is continuous, avoids superluminal propagation, and reduces to the standard Wiener process in the nonrelativistic limit. The corresponding relativistic diffusion propagator is obtained directly from the nonrelativistic Wiener propagator, by rewriting the latter in terms of an integral over actions. The resulting relativistic process is non-Markovian, in accordance with the known fact that nontrivial continuous, relativistic Markov processes in position space cannot exist. Hence, the proposed process defines a consistent relativistic diffusion model for massive particles and provides a viable alternative to the solutions of the telegraph equation.

  9. How to measure the agroecological performance of farming in order to assist with the transition process.

    PubMed

    Trabelsi, Meriam; Mandart, Elisabeth; Le Grusse, Philippe; Bord, Jean-Paul

    2016-01-01

    The use of plant protection products enables farmers to maximize economic performance and yields, but in return, the environment and human health can be greatly affected because of their toxicity. There are currently strong calls for farmers to reduce the use of these toxic products for the preservation of the environment and the human health, and it has become urgent to invest in more sustainable models that help reduce these risks. One possible solution is the transition toward agroecological production systems. These new systems must be beneficial economically, socially, and environmentally in terms of human health. There are many tools available, based on a range of indicators, for assessing the sustainability of agricultural systems on conventional farm holdings. These methods are little suitable to agroecological farms and do not measure the performance of agroecological transition farms. In this article, we therefore develop a model for the strategic definition, guidance, and assistance for a transition to agroecological practices, capable of assessing performance of this transition and simulating the consequences of possible changes. This model was built by coupling (i) a decision-support tool and a technico-economic simulator with (ii) a conceptual model built from the dynamics of agroecological practices. This tool is currently being tested in the framework of a Compte d'Affectation Spéciale pour le Développement Agricole et Rural (CASDAR) project (CASDAR: project launched in 2013 by the French Ministry of Agriculture, Food and Forestry, on the theme "collective mobilisation for agroecology," http://agriculture.gouv.fr/Appel-a-projets-CASDAR ) using data from farms, most of which are engaged in agroenvironmental process and reducing plant protection treatments since 2008.

  10. Dynamic Linkages Between the Transition Zone & Surface Plate Motions in 2D Models of Subduction

    NASA Astrophysics Data System (ADS)

    Arredondo, K.; Billen, M. I.

    2013-12-01

    While slab pull is considered the dominant force controlling plate motion and speed, its magnitude is controlled by slab behavior in the mantle, where tomographic studies show a wide range of possibilities from direct penetration to folding, or stagnation directly above the lower mantle (e.g. Fukao et al., 2009). Geodynamic studies have investigated various parameters, such as plate age and two phase transitions, to recreate observed behavior (e.g. Běhounková and Cízková, 2008). However, past geodynamic models have left out known slab characteristics that may have a large impact on slab behavior and our understanding of subduction processes. Mineral experiments and seismic observations have indicated the existence of additional phase transitions in the mantle transition zone that may produce buoyancy forces large enough to affect the descent of a subducting slab (e.g. Ricard et al., 2005). The current study systematically tests different common assumptions used in geodynamic models: kinematic versus free-slip boundary conditions, the effects of adiabatic heating, viscous dissipation and latent heat, compositional layering and a more complete suite of phase transitions. Final models have a complete energy equation, with eclogite, harzburgite and pyrolite lithosphere compositional layers, and seven composition-dependent phase transitions within the olivine, pyroxene and garnet polymorph minerals. Results show important feedback loops between different assumptions and new behavior from the most complete models. Kinematic models show slab weakening or breaking above the 660 km boundary and between compositional layers. The behavior in dynamic models with a free-moving trench and overriding plate is compared to the more commonly found kinematic models. The new behavior may have important implications for the depth distribution of deep earthquakes within the slab. Though the thermodynamic parameters of certain phase transitions may be uncertain, their presence and

  11. Turbulence and transition modeling for high-speed flows

    NASA Technical Reports Server (NTRS)

    Wilcox, David C.

    1993-01-01

    Research conducted during the past three and a half years aimed at developing and testing a turbulence/transition model applicable to high-speed turbulent flows is summarized. The first two years of the project focused on fully turbulent flows, while emphasis shifted to boundary-layer development in the transition region during the final year and a half. A brief summary of research accomplished during the first three years is included and publications that describe research results in greater detail are cited. Research conducted during the final six months of the period of performance is summarized. The primary results of the last six months of the project are elimination of the k-omega model's sensitivity to the freestream value of omega and development of a method for triggering transition at a specified location, independent of the freestream turbulence level.

  12. Predicting landscape vegetation dynamics using state-and-transition simulation models

    Treesearch

    Colin J. Daniel; Leonardo Frid

    2012-01-01

    This paper outlines how state-and-transition simulation models (STSMs) can be used to project changes in vegetation over time across a landscape. STSMs are stochastic, empirical simulation models that use an adapted Markov chain approach to predict how vegetation will transition between states over time, typically in response to interactions between succession,...

  13. Biomechanical modeling of reconstructive intervention on the thoracolumbar transition

    NASA Astrophysics Data System (ADS)

    Donnik, A. M.; Kirillova, I. V.; Kossovich, L. Yu.; Zaretskov, V. V.; Lykhachev, S. V.; Norkin, I. A.

    2018-05-01

    A finite-element model is presented for a healthy person and for a person with an injury in this section of the spine. The mechanical parameters of the bone tissue of the vertebrae, intervertebral discs, arcuate joints, and ligaments, are modeled on the basis of data from literature sources. Elements of the transitional thoracolumbar spine are considered as isotropic, homogeneous and linearly elastic material. The obtained models allow for a comparative analysis of the spine of a healthy person and the presence of injure in the transitional thoracolumbar spine.

  14. Metastable liquid-liquid transition in a molecular model of water

    NASA Astrophysics Data System (ADS)

    Palmer, Jeremy C.; Martelli, Fausto; Liu, Yang; Car, Roberto; Panagiotopoulos, Athanassios Z.; Debenedetti, Pablo G.

    2014-06-01

    Liquid water's isothermal compressibility and isobaric heat capacity, and the magnitude of its thermal expansion coefficient, increase sharply on cooling below the equilibrium freezing point. Many experimental, theoretical and computational studies have sought to understand the molecular origin and implications of this anomalous behaviour. Of the different theoretical scenarios put forward, one posits the existence of a first-order phase transition that involves two forms of liquid water and terminates at a critical point located at deeply supercooled conditions. Some experimental evidence is consistent with this hypothesis, but no definitive proof of a liquid-liquid transition in water has been obtained to date: rapid ice crystallization has so far prevented decisive measurements on deeply supercooled water, although this challenge has been overcome recently. Computer simulations are therefore crucial for exploring water's structure and behaviour in this regime, and have shown that some water models exhibit liquid-liquid transitions and others do not. However, recent work has argued that the liquid-liquid transition has been mistakenly interpreted, and is in fact a liquid-crystal transition in all atomistic models of water. Here we show, by studying the liquid-liquid transition in the ST2 model of water with the use of six advanced sampling methods to compute the free-energy surface, that two metastable liquid phases and a stable crystal phase exist at the same deeply supercooled thermodynamic condition, and that the transition between the two liquids satisfies the thermodynamic criteria of a first-order transition. We follow the rearrangement of water's coordination shell and topological ring structure along a thermodynamically reversible path from the low-density liquid to cubic ice. We also show that the system fluctuates freely between the two liquid phases rather than crystallizing. These findings provide unambiguous evidence for a liquid-liquid transition in

  15. Metastable liquid-liquid transition in a molecular model of water.

    PubMed

    Palmer, Jeremy C; Martelli, Fausto; Liu, Yang; Car, Roberto; Panagiotopoulos, Athanassios Z; Debenedetti, Pablo G

    2014-06-19

    Liquid water's isothermal compressibility and isobaric heat capacity, and the magnitude of its thermal expansion coefficient, increase sharply on cooling below the equilibrium freezing point. Many experimental, theoretical and computational studies have sought to understand the molecular origin and implications of this anomalous behaviour. Of the different theoretical scenarios put forward, one posits the existence of a first-order phase transition that involves two forms of liquid water and terminates at a critical point located at deeply supercooled conditions. Some experimental evidence is consistent with this hypothesis, but no definitive proof of a liquid-liquid transition in water has been obtained to date: rapid ice crystallization has so far prevented decisive measurements on deeply supercooled water, although this challenge has been overcome recently. Computer simulations are therefore crucial for exploring water's structure and behaviour in this regime, and have shown that some water models exhibit liquid-liquid transitions and others do not. However, recent work has argued that the liquid-liquid transition has been mistakenly interpreted, and is in fact a liquid-crystal transition in all atomistic models of water. Here we show, by studying the liquid-liquid transition in the ST2 model of water with the use of six advanced sampling methods to compute the free-energy surface, that two metastable liquid phases and a stable crystal phase exist at the same deeply supercooled thermodynamic condition, and that the transition between the two liquids satisfies the thermodynamic criteria of a first-order transition. We follow the rearrangement of water's coordination shell and topological ring structure along a thermodynamically reversible path from the low-density liquid to cubic ice. We also show that the system fluctuates freely between the two liquid phases rather than crystallizing. These findings provide unambiguous evidence for a liquid-liquid transition in

  16. Processes of code status transitions in hospitalized patients with advanced cancer.

    PubMed

    El-Jawahri, Areej; Lau-Min, Kelsey; Nipp, Ryan D; Greer, Joseph A; Traeger, Lara N; Moran, Samantha M; D'Arpino, Sara M; Hochberg, Ephraim P; Jackson, Vicki A; Cashavelly, Barbara J; Martinson, Holly S; Ryan, David P; Temel, Jennifer S

    2017-12-15

    Although hospitalized patients with advanced cancer have a low chance of surviving cardiopulmonary resuscitation (CPR), the processes by which they change their code status from full code to do not resuscitate (DNR) are unknown. We conducted a mixed-methods study on a prospective cohort of hospitalized patients with advanced cancer. Two physicians used a consensus-driven medical record review to characterize processes that led to code status order transitions from full code to DNR. In total, 1047 hospitalizations were reviewed among 728 patients. Admitting clinicians did not address code status in 53% of hospitalizations, resulting in code status orders of "presumed full." In total, 275 patients (26.3%) transitioned from full code to DNR, and 48.7% (134 of 275 patients) of those had an order of "presumed full" at admission; however, upon further clarification, the patients expressed that they had wished to be DNR before the hospitalization. We identified 3 additional processes leading to order transition from full code to DNR acute clinical deterioration (15.3%), discontinuation of cancer-directed therapy (17.1%), and education about the potential harms/futility of CPR (15.3%). Compared with discontinuing therapy and education, transitions because of acute clinical deterioration were associated with less patient involvement (P = .002), a shorter time to death (P < .001), and a greater likelihood of inpatient death (P = .005). One-half of code status order changes among hospitalized patients with advanced cancer were because of full code orders in patients who had a preference for DNR before hospitalization. Transitions due of acute clinical deterioration were associated with less patient engagement and a higher likelihood of inpatient death. Cancer 2017;123:4895-902. © 2017 American Cancer Society. © 2017 American Cancer Society.

  17. Reversibility in Quantum Models of Stochastic Processes

    NASA Astrophysics Data System (ADS)

    Gier, David; Crutchfield, James; Mahoney, John; James, Ryan

    Natural phenomena such as time series of neural firing, orientation of layers in crystal stacking and successive measurements in spin-systems are inherently probabilistic. The provably minimal classical models of such stochastic processes are ɛ-machines, which consist of internal states, transition probabilities between states and output values. The topological properties of the ɛ-machine for a given process characterize the structure, memory and patterns of that process. However ɛ-machines are often not ideal because their statistical complexity (Cμ) is demonstrably greater than the excess entropy (E) of the processes they represent. Quantum models (q-machines) of the same processes can do better in that their statistical complexity (Cq) obeys the relation Cμ >= Cq >= E. q-machines can be constructed to consider longer lengths of strings, resulting in greater compression. With code-words of sufficiently long length, the statistical complexity becomes time-symmetric - a feature apparently novel to this quantum representation. This result has ramifications for compression of classical information in quantum computing and quantum communication technology.

  18. The Transition Process: Towards Exclusion or Financial Sufficiency. A French-Irish Comparison.

    ERIC Educational Resources Information Center

    Grelet, Yvette; Mansuy, Michele; Thomas, Gwenaelle

    Data from longitudinal school leavers' surveys in France and Ireland were compared to determine types of transition pathways leading to unsuccessful conclusions. Focus was on outcomes of the transition process for school leavers unemployed five years after leaving and for employed young people whose earnings did not allow them to be financially…

  19. Providing Transition Planning for the Secondary Student through the Community Based Inservice Model.

    ERIC Educational Resources Information Center

    Glasenapp, Gary

    This paper provides an overview of the transition process for students with severe handicaps. For secondary age youths with severe handicaps, explicit and intensive transition planning is necessary to bridge the gap between school experiences and adult life. The transition planning process is designed to build the skills necessary for an…

  20. Toward the Darwinian transition: Switching between distributed and speciated states in a simple model of early life.

    PubMed

    Arnoldt, Hinrich; Strogatz, Steven H; Timme, Marc

    2015-01-01

    It has been hypothesized that in the era just before the last universal common ancestor emerged, life on earth was fundamentally collective. Ancient life forms shared their genetic material freely through massive horizontal gene transfer (HGT). At a certain point, however, life made a transition to the modern era of individuality and vertical descent. Here we present a minimal model for stochastic processes potentially contributing to this hypothesized "Darwinian transition." The model suggests that HGT-dominated dynamics may have been intermittently interrupted by selection-driven processes during which genotypes became fitter and decreased their inclination toward HGT. Stochastic switching in the population dynamics with three-point (hypernetwork) interactions may have destabilized the HGT-dominated collective state and essentially contributed to the emergence of vertical descent and the first well-defined species in early evolution. A systematic nonlinear analysis of the stochastic model dynamics covering key features of evolutionary processes (such as selection, mutation, drift and HGT) supports this view. Our findings thus suggest a viable direction out of early collective evolution, potentially enabling the start of individuality and vertical Darwinian evolution.

  1. Proton-neutron sdg boson model and spherical-deformed phase transition

    NASA Astrophysics Data System (ADS)

    Otsuka, Takaharu; Sugita, Michiaki

    1988-12-01

    The spherical-deformed phase transition in nuclei is described in terms of the proton-neutron sdg interacting boson model. The sdg hamiltonian is introduced to model the pairing+quadrupole interaction. The phase transition is reproduced in this framework as a function of the boson number in the Sm isotopes, while all parameters in the hamiltonian are kept constant at values reasonable from the shell-model point of view. The sd IBM is derived from this model through the renormalization of g-boson effects.

  2. Medical care transition planning and dental care use for youth with special health care needs during the transition from adolescence to young adulthood: a preliminary explanatory model

    PubMed Central

    Chi, Donald L.

    2013-01-01

    Objectives To test the hypotheses that youth with special health care needs (YSHCN) with a medical care transition plan are more likely to use dental care during the transition from adolescence to young adulthood and that different factors are associated with dental utilization for YSHCN with and YSHCN without functional limitations. Methods National Survey of CSHCN (2001) and Survey of Adult Transition and Health (2007) data were analyzed (N=1,746). The main predictor variable was having a medical care transition plan, defined as having discussed with a doctor how health care needs might change with age and having developed a transition plan. The outcome variable was dental care use in 2001 (adolescence) and 2007 (young adulthood). Multiple variable Poisson regression models with robust standard errors were used to estimate covariate-adjusted relative risks (RR). Results About 63% of YSHCN had a medical care transition plan and 73.5% utilized dental care. YSHCN with a medical care transition plan had a 9% greater relative risk (RR) of utilizing dental care than YSHCN without a medical care transition plan (RR:1.09; 95% CI:1.03–1.16). In the models stratified by functional limitation status, having a medical care transition plan was significantly associated with dental care use, but only for YSHCN without functional limitations (RR:1.11; 95% CI:1.04–1.18). Conclusions Having a medical care transition plan is significantly associated with dental care use, but only for YSHCN with no functional limitation. Dental care should be an integral part of the comprehensive health care transition planning process for all YSHCN. PMID:23812799

  3. Bypass Transitional Flow Calculations Using a Navier-Stokes Solver and Two-Equation Models

    NASA Technical Reports Server (NTRS)

    Liuo, William W.; Shih, Tsan-Hsing; Povinelli, L. A. (Technical Monitor)

    2000-01-01

    Bypass transitional flows over a flat plate were simulated using a Navier-Stokes solver and two equation models. A new model for the bypass transition, which occurs in cases with high free stream turbulence intensity (TI), is described. The new transition model is developed by including an intermittency correction function to an existing two-equation turbulence model. The advantages of using Navier-Stokes equations, as opposed to boundary-layer equations, in bypass transition simulations are also illustrated. The results for two test flows over a flat plate with different levels of free stream turbulence intensity are reported. Comparisons with the experimental measurements show that the new model can capture very well both the onset and the length of bypass transition.

  4. Model of Transition from Laminar to Turbulent Flow

    NASA Astrophysics Data System (ADS)

    Kanda, Hidesada

    2001-11-01

    For circular pipe flows, a model of transition from laminar to turbulent flow has already been proposed and the minimum critical Reynolds number of approximately 2040 was obtained (Kanda, 1999). In order to prove the validity of the model, another verification is required. Thus, for plane Poiseuille flow, results of previous investigations were studied, focusing on experimental data on the critical Reynolds number Rc, the entrance length, and the transition length. Consequently, concerning the natural transition, it was confirmed from the experimental data that (i) the transition occurs in the entrance region, (ii) Rc increases as the contraction ratio in the inlet section increases, and (iii) the minimum Rc is obtained when the contraction ratio is the smallest or one, and there is no-bellshaped entrance or straight parallel plates. Its value exists in the neighborhood of 1300, based on the channel height and the average velocity. Although, for Hagen-Poiseuille flow, the minimum Rc is approximately 2000, based on the pipe diameter and the average velocity, there seems to be no significant difference in the transition from laminar to turbulent flow between Hagen-Poiseuille flow and plane Poiseuille flow (Kanda, 2001). Rc is determined by the shape of the inlet. Kanda, H., 1999, Proc. of ASME Fluids Engineering Division - 1999, FED-Vol. 250, pp. 197-204. Kanda, H., 2001, Proc. of ASME Fluids Engineering Division - 2001.

  5. Transition between Functional Regimes in an Integrate-And-Fire Network Model of the Thalamus

    PubMed Central

    Barardi, Alessandro; Mazzoni, Alberto

    2016-01-01

    The thalamus is a key brain element in the processing of sensory information. During the sleep and awake states, this brain area is characterized by the presence of two distinct dynamical regimes: in the sleep state activity is dominated by spindle oscillations (7 − 15 Hz) weakly affected by external stimuli, while in the awake state the activity is primarily driven by external stimuli. Here we develop a simple and computationally efficient model of the thalamus that exhibits two dynamical regimes with different information-processing capabilities, and study the transition between them. The network model includes glutamatergic thalamocortical (TC) relay neurons and GABAergic reticular (RE) neurons described by adaptive integrate-and-fire models in which spikes are induced by either depolarization or hyperpolarization rebound. We found a range of connectivity conditions under which the thalamic network composed by these neurons displays the two aforementioned dynamical regimes. Our results show that TC-RE loops generate spindle-like oscillations and that a minimum level of clustering (i.e. local connectivity density) in the RE-RE connections is necessary for the coexistence of the two regimes. We also observe that the transition between the two regimes occurs when the external excitatory input on TC neurons (mimicking sensory stimulation) is large enough to cause a significant fraction of them to switch from hyperpolarization-rebound-driven firing to depolarization-driven firing. Overall, our model gives a novel and clear description of the role that the two types of neurons and their connectivity play in the dynamical regimes observed in the thalamus, and in the transition between them. These results pave the way for the development of efficient models of the transmission of sensory information from periphery to cortex. PMID:27598260

  6. The putative liquid-liquid transition is a liquid-solid transition in atomistic models of water

    NASA Astrophysics Data System (ADS)

    Limmer, David T.; Chandler, David

    2011-10-01

    We use numerical simulation to examine the possibility of a reversible liquid-liquid transition in supercooled water and related systems. In particular, for two atomistic models of water, we have computed free energies as functions of multiple order parameters, where one is density and another distinguishes crystal from liquid. For a range of temperatures and pressures, separate free energy basins for liquid and crystal are found, conditions of phase coexistence between these phases are demonstrated, and time scales for equilibration are determined. We find that at no range of temperatures and pressures is there more than a single liquid basin, even at conditions where amorphous behavior is unstable with respect to the crystal. We find a similar result for a related model of silicon. This result excludes the possibility of the proposed liquid-liquid critical point for the models we have studied. Further, we argue that behaviors others have attributed to a liquid-liquid transition in water and related systems are in fact reflections of transitions between liquid and crystal.

  7. Phase Transitions in a Model for Social Learning via the Internet

    NASA Astrophysics Data System (ADS)

    Bordogna, Clelia M.; Albano, Ezequiel V.

    Based on the concepts of educational psychology, sociology and statistical physics, a mathematical model for a new type of social learning process that takes place when individuals interact via the Internet is proposed and studied. The noise of the interaction (misunderstandings, lack of well organized participative activities, etc.) dramatically restricts the number of individuals that can be efficiently in mutual contact and drives phase transitions between ``ordered states'' such as the achievements of the individuals are satisfactory and ``disordered states'' with negligible achievements.

  8. Bethe Ansatz for the Weakly Asymmetric Simple Exclusion Process and Phase Transition in the Current Distribution

    NASA Astrophysics Data System (ADS)

    Simon, Damien

    2011-03-01

    The probability distribution of the current in the asymmetric simple exclusion process is expected to undergo a phase transition in the regime of weak asymmetry of the jumping rates. This transition was first predicted by Bodineau and Derrida using a linear stability analysis of the hydrodynamical limit of the process and further arguments have been given by Mallick and Prolhac. However it has been impossible so far to study what happens after the transition. The present paper presents an analysis of the large deviation function of the current on both sides of the transition from a Bethe Ansatz approach of the weak asymmetry regime of the exclusion process.

  9. Model independent constraints on transition redshift

    NASA Astrophysics Data System (ADS)

    Jesus, J. F.; Holanda, R. F. L.; Pereira, S. H.

    2018-05-01

    This paper aims to put constraints on the transition redshift zt, which determines the onset of cosmic acceleration, in cosmological-model independent frameworks. In order to perform our analyses, we consider a flat universe and assume a parametrization for the comoving distance DC(z) up to third degree on z, a second degree parametrization for the Hubble parameter H(z) and a linear parametrization for the deceleration parameter q(z). For each case, we show that type Ia supernovae and H(z) data complement each other on the parameter space and tighter constrains for the transition redshift are obtained. By combining the type Ia supernovae observations and Hubble parameter measurements it is possible to constrain the values of zt, for each approach, as 0.806± 0.094, 0.870± 0.063 and 0.973± 0.058 at 1σ c.l., respectively. Then, such approaches provide cosmological-model independent estimates for this parameter.

  10. Implementation of an inter-agency transition model for youth with spina bifida.

    PubMed

    Lindsay, S; Cruickshank, H; McPherson, A C; Maxwell, J

    2016-03-01

    To address gaps in transfer of care and transition support, a paediatric hospital and adult community health care centre partnered to implement an inter-agency transition model for youth with spina bifida. Our objective was to understand the enablers and challenges experienced in the implementation of the model. Using a descriptive, qualitative design, we conducted semi-structured interviews, in-person or over the phone, with 12 clinicians and nine key informants involved in implementing the spina bifida transition model. We recruited all 21 participants from an urban area of Ontario, Canada. Clinicians and key informants experienced several enablers and challenges in implementing the spina bifida transition model. Enablers included dedicated leadership, advocacy, funding, inter-agency partnerships, cross-appointed staff and gaps in co-ordinated care to connect youth to adult services. Challenges included gaps in the availability of adult specialty services, limited geographical catchment of adult services, limited engagement of front-line staff, gaps in communication and role clarity. Although the transition model has realized some initial successes, there are still many challenges to overcome in transferring youth with spina bifida to adult health care and transitioning to adulthood. © 2015 John Wiley & Sons Ltd.

  11. Transition to synchrony in degree-frequency correlated Sakaguchi-Kuramoto model

    NASA Astrophysics Data System (ADS)

    Kundu, Prosenjit; Khanra, Pitambar; Hens, Chittaranjan; Pal, Pinaki

    2017-11-01

    We investigate transition to synchrony in degree-frequency correlated Sakaguchi-Kuramoto (SK) model on complex networks both analytically and numerically. We analytically derive self-consistent equations for group angular velocity and order parameter for the model in the thermodynamic limit. Using the self-consistent equations we investigate transition to synchronization in SK model on uncorrelated scale-free (SF) and Erdős-Rényi (ER) networks in detail. Depending on the degree distribution exponent (γ ) of SF networks and phase-frustration parameter, the population undergoes from first-order transition [explosive synchronization (ES)] to second-order transition and vice versa. In ER networks transition is always second order irrespective of the values of the phase-lag parameter. We observe that the critical coupling strength for the onset of synchronization is decreased by phase-frustration parameter in case of SF network where as in ER network, the phase-frustration delays the onset of synchronization. Extensive numerical simulations using SF and ER networks are performed to validate the analytical results. An analytical expression of critical coupling strength for the onset of synchronization is also derived from the self-consistent equations considering the vanishing order parameter limit.

  12. Viewing brain processes as Critical State Transitions across levels of organization: Neural events in Cognition and Consciousness, and general principles.

    PubMed

    Werner, Gerhard

    2009-04-01

    In this theoretical and speculative essay, I propose that insights into certain aspects of neural system functions can be gained from viewing brain function in terms of the branch of Statistical Mechanics currently referred to as "Modern Critical Theory" [Stanley, H.E., 1987. Introduction to Phase Transitions and Critical Phenomena. Oxford University Press; Marro, J., Dickman, R., 1999. Nonequilibrium Phase Transitions in Lattice Models. Cambridge University Press, Cambridge, UK]. The application of this framework is here explored in two stages: in the first place, its principles are applied to state transitions in global brain dynamics, with benchmarks of Cognitive Neuroscience providing the relevant empirical reference points. The second stage generalizes to suggest in more detail how the same principles could also apply to the relation between other levels of the structural-functional hierarchy of the nervous system and between neural assemblies. In this view, state transitions resulting from the processing at one level are the input to the next, in the image of a 'bucket brigade', with the content of each bucket being passed on along the chain, after having undergone a state transition. The unique features of a process of this kind will be discussed and illustrated.

  13. An aggregate method to calibrate the reference point of cumulative prospect theory-based route choice model for urban transit network

    NASA Astrophysics Data System (ADS)

    Zhang, Yufeng; Long, Man; Luo, Sida; Bao, Yu; Shen, Hanxia

    2015-12-01

    Transit route choice model is the key technology of public transit systems planning and management. Traditional route choice models are mostly based on expected utility theory which has an evident shortcoming that it cannot accurately portray travelers' subjective route choice behavior for their risk preferences are not taken into consideration. Cumulative prospect theory (CPT), a brand new theory, can be used to describe travelers' decision-making process under the condition of uncertainty of transit supply and risk preferences of multi-type travelers. The method to calibrate the reference point, a key parameter to CPT-based transit route choice model, determines the precision of the model to a great extent. In this paper, a new method is put forward to obtain the value of reference point which combines theoretical calculation and field investigation results. Comparing the proposed method with traditional method, it shows that the new method can promote the quality of CPT-based model by improving the accuracy in simulating travelers' route choice behaviors based on transit trip investigation from Nanjing City, China. The proposed method is of great significance to logical transit planning and management, and to some extent makes up the defect that obtaining the reference point is solely based on qualitative analysis.

  14. A Catalog of Transit Timing Posterior Distributions for all Kepler Planet Candidate Transit Events

    NASA Astrophysics Data System (ADS)

    Montet, Benjamin Tyler; Becker, Juliette C.; Johnson, John Asher

    2015-12-01

    Kepler has ushered in a new era of planetary dynamics, enabling the detection of interactions between multiple planets in transiting systems for hundreds of systems. These interactions, observed as transit timing variations (TTVs), have been used to find non-transiting companions to transiting systems and to measure masses, eccentricities, and inclinations of transiting planets. Often, physical parameters are inferred by comparing the observed light curve to the result of a photodynamical model, a time-intensive process that often ignores the effects of correlated noise in the light curve. Catalogs of transit timing observations have previously neglected non-Gaussian uncertainties in the times of transit, uncertainties in the transit shape, and short cadence data. Here, I present a catalog of not only times of transit centers, but also posterior distributions on the time of transit for every planet candidate transit event in the Kepler data, developed through importance sampling of each transit. This catalog allows one to marginalize over uncertainties in the transit shape and incorporate short cadence data, the effects of correlated noise, and non-Gaussian posteriors. Our catalog will enable dynamical studies that reflect accurately the precision of Kepler and its limitations without requiring the computational power to model the light curve completely with every integration. I will also present our open-source N-body photodynamical modeling code, which integrates planetary and stellar orbits accounting for the effects of GR, tidal effects, and Doppler beaming.

  15. Modelling gait transition in two-legged animals

    NASA Astrophysics Data System (ADS)

    Pinto, Carla M. A.; Santos, Alexandra P.

    2011-12-01

    The study of locomotor patterns has been a major research goal in the last decades. Understanding how intralimb and interlimb coordination works out so well in animals' locomotion is a hard and challenging task. Many models have been proposed to model animal's rhythms. These models have also been applied to the control of rhythmic movements of adaptive legged robots, namely biped, quadruped and other designs. In this paper we study gait transition in a central pattern generator (CPG) model for bipeds, the 4-cells model. This model is proposed by Golubitsky, Stewart, Buono and Collins and is studied further by Pinto and Golubitsky. We briefly resume the work done by Pinto and Golubitsky. We compute numerically gait transition in the 4-cells CPG model for bipeds. We use Morris-Lecar equations and Wilson-Cowan equations as the internal dynamics for each cell. We also consider two types of coupling between the cells: diffusive and synaptic. We obtain secondary gaits by bifurcation of primary gaits, by varying the coupling strengths. Nevertheless, some bifurcating branches could not be obtained, emphasizing the fact that despite analytically those bifurcations exist, finding them is a hard task and requires variation of other parameters of the equations. We note that the type of coupling did not influence the results.

  16. Negotiating uncertainty: the transitional process of adapting to life with HIV.

    PubMed

    Perrett, Stephanie E; Biley, Francis C

    2013-01-01

    Glaser's (1978) grounded-theory method was used to investigate the transitional process of adapting to life with HIV. Semistructured interviews took place with 8 male HIV-infected participants recruited from a clinic in South Wales, United Kingdom. Data analysis used open, substantive, and theoretical coding. Adapting to a life with HIV infection emerged as a process of adapting to uncertainty with "negotiating uncertainty" as a core concept. Seven subcategories represented movements between bipolar opposites labeled "anticipating hopelessness" and "regaining optimism." This work progresses the theoretical concepts of transitions, uncertainty, and adaptation in relation to the HIV experience. Copyright © 2013 Association of Nurses in AIDS Care. Published by Elsevier Inc. All rights reserved.

  17. Transitional paleointensities from Kauai, Hawaii, and geomagnetic reversal models

    USGS Publications Warehouse

    Bogue, Scott W.; Coe, Robert S.

    1984-01-01

    Previously presented paleointensity results from an R-N transition zone in Kauai, Hawaii, show that field intensity dropped from 0. 431 Oe to 0. 101 Oe while the field remained within 30 degree of the reversed axial dipole direction. A recovery in intensity and the main directional change followed this presumably short period of low field strength. As the reversal neared completion, the field has an intensity of 0. 217 Oe while still 40 degree from the final direction. The relationship of paleointensity to field direction during the early part of the reversal thus differs from that toward the end, a feature that only some reversal models are consistent with. For example, a model in which a standing nondipole component persists through the dipole reversal predicts only symmetric intensity patterns. In contrast, zonal flooding models generate suitably complex field behavior if multiple flooding schemes operate during a single reversal or if the flooding process is itself asymmetric.

  18. Unified Model Deformation and Flow Transition Measurements

    NASA Technical Reports Server (NTRS)

    Burner, Alpheus W.; Liu, Tianshu; Garg, Sanjay; Bell, James H.; Morgan, Daniel G.

    1999-01-01

    The number of optical techniques that may potentially be used during a given wind tunnel test is continually growing. These include parameter sensitive paints that are sensitive to temperature or pressure, several different types of off-body and on-body flow visualization techniques, optical angle-of-attack (AoA), optical measurement of model deformation, optical techniques for determining density or velocity, and spectroscopic techniques for determining various flow field parameters. Often in the past the various optical techniques were developed independently of each other, with little or no consideration for other techniques that might also be used during a given test. Recently two optical techniques have been increasingly requested for production measurements in NASA wind tunnels. These are the video photogrammetric (or videogrammetric) technique for measuring model deformation known as the video model deformation (VMD) technique, and the parameter sensitive paints for making global pressure and temperature measurements. Considerations for, and initial attempts at, simultaneous measurements with the pressure sensitive paint (PSP) and the videogrammetric techniques have been implemented. Temperature sensitive paint (TSP) has been found to be useful for boundary-layer transition detection since turbulent boundary layers convect heat at higher rates than laminar boundary layers of comparable thickness. Transition is marked by a characteristic surface temperature change wherever there is a difference between model and flow temperatures. Recently, additional capabilities have been implemented in the target-tracking videogrammetric measurement system. These capabilities have permitted practical simultaneous measurements using parameter sensitive paint and video model deformation measurements that led to the first successful unified test with TSP for transition detection in a large production wind tunnel.

  19. Mixed-order phase transition of the contact process near multiple junctions.

    PubMed

    Juhász, Róbert; Iglói, Ferenc

    2017-02-01

    We have studied the phase transition of the contact process near a multiple junction of M semi-infinite chains by Monte Carlo simulations. As opposed to the continuous transitions of the translationally invariant (M=2) and semi-infinite (M=1) system, the local order parameter is found to be discontinuous for M>2. Furthermore, the temporal correlation length diverges algebraically as the critical point is approached, but with different exponents on the two sides of the transition. In the active phase, the estimate is compatible with the bulk value, while in the inactive phase it exceeds the bulk value and increases with M. The unusual local critical behavior is explained by a scaling theory with an irrelevant variable, which becomes dangerous in the inactive phase. Quenched spatial disorder is found to make the transition continuous in agreement with earlier renormalization group results.

  20. Encapsulating model complexity and landscape-scale analyses of state-and-transition simulation models: an application of ecoinformatics and juniper encroachment in sagebrush steppe ecosystems

    USGS Publications Warehouse

    O'Donnell, Michael

    2015-01-01

    State-and-transition simulation modeling relies on knowledge of vegetation composition and structure (states) that describe community conditions, mechanistic feedbacks such as fire that can affect vegetation establishment, and ecological processes that drive community conditions as well as the transitions between these states. However, as the need for modeling larger and more complex landscapes increase, a more advanced awareness of computing resources becomes essential. The objectives of this study include identifying challenges of executing state-and-transition simulation models, identifying common bottlenecks of computing resources, developing a workflow and software that enable parallel processing of Monte Carlo simulations, and identifying the advantages and disadvantages of different computing resources. To address these objectives, this study used the ApexRMS® SyncroSim software and embarrassingly parallel tasks of Monte Carlo simulations on a single multicore computer and on distributed computing systems. The results demonstrated that state-and-transition simulation models scale best in distributed computing environments, such as high-throughput and high-performance computing, because these environments disseminate the workloads across many compute nodes, thereby supporting analysis of larger landscapes, higher spatial resolution vegetation products, and more complex models. Using a case study and five different computing environments, the top result (high-throughput computing versus serial computations) indicated an approximate 96.6% decrease of computing time. With a single, multicore compute node (bottom result), the computing time indicated an 81.8% decrease relative to using serial computations. These results provide insight into the tradeoffs of using different computing resources when research necessitates advanced integration of ecoinformatics incorporating large and complicated data inputs and models. - See more at: http

  1. Stochastic Modeling of Laminar-Turbulent Transition

    NASA Technical Reports Server (NTRS)

    Rubinstein, Robert; Choudhari, Meelan

    2002-01-01

    Stochastic versions of stability equations are developed in order to develop integrated models of transition and turbulence and to understand the effects of uncertain initial conditions on disturbance growth. Stochastic forms of the resonant triad equations, a high Reynolds number asymptotic theory, and the parabolized stability equations are developed.

  2. Modeling of Flow Transition Using an Intermittency Transport Equation

    NASA Technical Reports Server (NTRS)

    Suzen, Y. B.; Huang, P. G.

    1999-01-01

    A new transport equation for intermittency factor is proposed to model transitional flows. The intermittent behavior of the transitional flows is incorporated into the computations by modifying the eddy viscosity, mu(sub t), obtainable from a turbulence model, with the intermittency factor, gamma: mu(sub t, sup *) = gamma.mu(sub t). In this paper, Menter's SST model (Menter, 1994) is employed to compute mu(sub t) and other turbulent quantities. The proposed intermittency transport equation can be considered as a blending of two models - Steelant and Dick (1996) and Cho and Chung (1992). The former was proposed for near-wall flows and was designed to reproduce the streamwise variation of the intermittency factor in the transition zone following Dhawan and Narasimha correlation (Dhawan and Narasimha, 1958) and the latter was proposed for free shear flows and was used to provide a realistic cross-stream variation of the intermittency profile. The new model was used to predict the T3 series experiments assembled by Savill (1993a, 1993b) including flows with different freestream turbulence intensities and two pressure-gradient cases. For all test cases good agreements between the computed results and the experimental data are observed.

  3. [Process of land use transition and its impact on regional ecological quality in the Middle Reaches of Heihe River, China].

    PubMed

    Wang, Fu Hong; Zhao, Rui Feng; Zhang, Li Hua; Li, Hong Wei

    2017-12-01

    Land use transition is one of the main drivers of regional ecosystem change in arid area, which directly affects human well-being. Based on the satellite images of 1987, 2001 and 2016, the change detection assessment model and ecological response model were used to analyze the process of land use transition and response of ecological quality during 1987-2016 in the ecologically fragile middle reaches of the Heihe River. The results showed that the land use change was significant during 1987-2016 and the total change increased significantly, as well as the continuous increase of the cultivated land and construction land. There was a strong tendency of transform from grassland to cultivated land, while the tendency of transforming unused land to other land classes was not strong under a random process of gain or loss. During 1987-2016, the ecological quality of the study area displayed a decreasing trend as a whole and the ecological land decreased by 2.8%. The land use transition with the greatest impact on the ecological environment degradation was the transition of the grassland to the cultivated land and unused land. Therefore, in order to promote the sustainable use of regional land resources and to improve the regional ecological quality, it is necessary to allocate the proportion of production land and ecological land according to the regional water resources.

  4. NASA Trapezoidal Wing Computations Including Transition and Advanced Turbulence Modeling

    NASA Technical Reports Server (NTRS)

    Rumsey, C. L.; Lee-Rausch, E. M.

    2012-01-01

    Flow about the NASA Trapezoidal Wing is computed with several turbulence models by using grids from the first High Lift Prediction Workshop in an effort to advance understanding of computational fluid dynamics modeling for this type of flowfield. Transition is accounted for in many of the computations. In particular, a recently-developed 4-equation transition model is utilized and works well overall. Accounting for transition tends to increase lift and decrease moment, which improves the agreement with experiment. Upper surface flap separation is reduced, and agreement with experimental surface pressures and velocity profiles is improved. The predicted shape of wakes from upstream elements is strongly influenced by grid resolution in regions above the main and flap elements. Turbulence model enhancements to account for rotation and curvature have the general effect of increasing lift and improving the resolution of the wing tip vortex as it convects downstream. However, none of the models improve the prediction of surface pressures near the wing tip, where more grid resolution is needed.

  5. Do state-and-transition models derived from vegetation succession also represent avian succession in restored mine pits?

    PubMed

    Craig, Michael D; Stokes, Vicki L; Fontaine, Joseph B; Hardy, Giles E StJ; Grigg, Andrew H; Hobbs, Richard J

    2015-10-01

    State-and-transition models are increasingly used as a tool to inform management of post-disturbance succession and effective conservation of biodiversity in production landscapes. However, if they are to do this effectively, they need to represent faunal, as well as vegetation, succession. We assessed the congruence between vegetation and avian succession by sampling avian communities in each state of a state-and-transition model used to inform management of post-mining restoration in a production landscape in southwestern Australia. While avian communities differed significantly among states classified as on a desirable successional pathway, they did not differ between desirable and deviated states of the same post-mining age. Overall, we concluded there was poor congruence between vegetation and avian succession in this state-and-transition model. We identified four factors that likely contributed to this lack of congruence, which were that long-term monitoring of succession in restored mine pits was not used to update and improve models, states were not defined based on ecological processes and thresholds, states were not defined by criteria that were important in structuring the avian community, and states were not based on criteria that related to values in the reference community. We believe that consideration of these four factors in the development of state-and-transition models should improve their ability to accurately represent faunal, as well as vegetation, succession. Developing state-and-transition models that better incorporate patterns of faunal succession should improve the ability to manage post-disturbance succession across a range of ecosystems for biodiversity conservation.

  6. Geomagnetic polarity transitions

    NASA Astrophysics Data System (ADS)

    Merrill, Ronald T.; McFadden, Phillip L.

    1999-05-01

    The top of Earth's liquid outer core is nearly 2900 km beneath Earth's surface, so we will never be able to observe it directly. This hot, dense, molten iron-rich body is continuously in motion and is the source of Earth's magnetic field. One of the most dynamic manifestations at Earth's surface of this fluid body is, perhaps, a reversal of the geomagnetic field. Unfortunately, the most recent polarity transition occurred at about 780 ka, so we have never observed a transition directly. It seems that a polarity transition spans many human lifetimes, so no human will ever witness the phenomenon in its entirety. Thus we are left with the tantalizing prospect that paleomagnetic records of polarity transitions may betray some of the secrets of the deep Earth. Certainly, if there are systematics in the reversal process and they can be documented, then this will reveal substantial information about the nature of the lowermost mantle and of the outer core. Despite their slowness on a human timescale, polarity transitions occur almost instantaneously on a geological timescale. This rapidity, together with limitations in the paleomagnetic recording process, prohibits a comprehensive description of any reversal transition both now and into the foreseeable future, which limits the questions that may at this stage be sensibly asked. The natural model for the geomagnetic field is a set of spherical harmonic components, and we are not able to obtain a reliable model for even the first few harmonic terms during a transition. Nevertheless, it is possible, in principle, to make statements about the harmonic character of a geomagnetic polarity transition without having a rigorous spherical harmonic description of one. For example, harmonic descriptions of recent geomagnetic polarity transitions that are purely zonal can be ruled out (a zonal harmonic does not change along a line of latitude). Gleaning information about transitions has proven to be difficult, but it does seem

  7. Gaze data reveal distinct choice processes underlying model-based and model-free reinforcement learning

    PubMed Central

    Konovalov, Arkady; Krajbich, Ian

    2016-01-01

    Organisms appear to learn and make decisions using different strategies known as model-free and model-based learning; the former is mere reinforcement of previously rewarded actions and the latter is a forward-looking strategy that involves evaluation of action-state transition probabilities. Prior work has used neural data to argue that both model-based and model-free learners implement a value comparison process at trial onset, but model-based learners assign more weight to forward-looking computations. Here using eye-tracking, we report evidence for a different interpretation of prior results: model-based subjects make their choices prior to trial onset. In contrast, model-free subjects tend to ignore model-based aspects of the task and instead seem to treat the decision problem as a simple comparison process between two differentially valued items, consistent with previous work on sequential-sampling models of decision making. These findings illustrate a problem with assuming that experimental subjects make their decisions at the same prescribed time. PMID:27511383

  8. Model Atmospheres and Transit Spectra for Hot Rocky Planets

    NASA Astrophysics Data System (ADS)

    Lupu, Roxana

    hot Jupiters in similar transit configurations. For example, Na has been the first species to be detected in an exoplanet atmosphere, by observing the evaporating hotJupiter HD209458b. Understanding the interplay between the magma outgassing and volatile loss will be an important part of this project. Our team has the expertise in the chemistry, radiative transfer, and atmospheric escape modeling at these exotic temperatures. Our recent work has analyzed the emerging atmospheres of terrestrial planets after giant impacts, using a well-established radiativeconvective atmospheric structure code, with an extensive opacity database for all relevant molecules, and the chemistry self-consistently calculated for continental crust and bulk silicate earth compositions. We will expand on this work by considering a wider range of chemical compositions, assessing the importance of clouds and generating cloudy models, and developing dis-equilibrium models by taking into account vertical mixing and photochemistry. Photo-evaporation will be considered in the energy balance between heating, cooling and mass loss. We also have in-house codes to generate high-resolution eclipse spectra and predict transit depths and observable signatures. The development of the atmospheric code, the molecular opacity updates, the atmospheric structure calculations and the high resolution eclipse spectra will be performed by R. Lupu, M. Marley, and R. Freedman at NASA Ames. The atmospheric chemistry grids will be provided by B. Fegley and K. Lodders at Washington University. The transit spectra and observational features will be computed by J. Fortney at UCSC, and the atmospheric escape calculations will be performed by K. Zahnle at NASA Ames. This proposal addresses the following goals of the Exoplanet Research program: explain observations of exoplanetary systems, and understand the chemical and physical processes of exoplanets. Our results will also inform future JWST observations.

  9. An analysis of the massless planet approximation in transit light curve models

    NASA Astrophysics Data System (ADS)

    Millholland, Sarah; Ruch, Gerry

    2015-08-01

    Many extrasolar planet transit light curve models use the approximation of a massless planet. They approximate the planet as orbiting elliptically with the host star at the orbit’s focus instead of depicting the planet and star as both orbiting around a common center of mass. This approximation should generally be very good because the transit is a small fraction of the full-phase curve and the planet to stellar mass ratio is typically very small. However, to fully examine the legitimacy of this approximation, it is useful to perform a robust, all-parameter space-encompassing statistical comparison between the massless planet model and the more accurate model.Towards this goal, we establish two questions: (1) In what parameter domain is the approximation invalid? (2) If characterizing an exoplanetary system in this domain, what is the error of the parameter estimates when using the simplified model? We first address question (1). Given each parameter vector in a finite space, we can generate the simplified and more complete model curves. Associated with these model curves is a measure of the deviation between them, such as the root mean square (RMS). We use Gibbs sampling to generate a sample that is distributed according to the RMS surface. The high-density regions in the sample correspond to a large deviation between the models. To determine the domains of these high-density areas, we first employ the Ordering Points to Identify the Clustering Structure (OPTICS) algorithm. We then characterize the subclusters by performing the Patient Rule Induction Method (PRIM) on the transformed Principal Component spaces of each cluster. This process yields descriptors of the parameter domains with large discrepancies between the models.To consider question (2), we start by generating synthetic transit curve observations in the domains specified by the above analysis. We then derive the best-fit parameters of these synthetic light curves according to each model and examine

  10. Nonequilibrium transitions in complex networks: A model of social interaction

    NASA Astrophysics Data System (ADS)

    Klemm, Konstantin; Eguíluz, Víctor M.; Toral, Raúl; San Miguel, Maxi

    2003-02-01

    We analyze the nonequilibrium order-disorder transition of Axelrod’s model of social interaction in several complex networks. In a small-world network, we find a transition between an ordered homogeneous state and a disordered state. The transition point is shifted by the degree of spatial disorder of the underlying network, the network disorder favoring ordered configurations. In random scale-free networks the transition is only observed for finite size systems, showing system size scaling, while in the thermodynamic limit only ordered configurations are always obtained. Thus, in the thermodynamic limit the transition disappears. However, in structured scale-free networks, the phase transition between an ordered and a disordered phase is restored.

  11. Multistate modeling of habitat dynamics: Factors affecting Florida scrub transition probabilities

    USGS Publications Warehouse

    Breininger, D.R.; Nichols, J.D.; Duncan, B.W.; Stolen, Eric D.; Carter, G.M.; Hunt, D.K.; Drese, J.H.

    2010-01-01

    Many ecosystems are influenced by disturbances that create specific successional states and habitat structures that species need to persist. Estimating transition probabilities between habitat states and modeling the factors that influence such transitions have many applications for investigating and managing disturbance-prone ecosystems. We identify the correspondence between multistate capture-recapture models and Markov models of habitat dynamics. We exploit this correspondence by fitting and comparing competing models of different ecological covariates affecting habitat transition probabilities in Florida scrub and flatwoods, a habitat important to many unique plants and animals. We subdivided a large scrub and flatwoods ecosystem along central Florida's Atlantic coast into 10-ha grid cells, which approximated average territory size of the threatened Florida Scrub-Jay (Aphelocoma coerulescens), a management indicator species. We used 1.0-m resolution aerial imagery for 1994, 1999, and 2004 to classify grid cells into four habitat quality states that were directly related to Florida Scrub-Jay source-sink dynamics and management decision making. Results showed that static site features related to fire propagation (vegetation type, edges) and temporally varying disturbances (fires, mechanical cutting) best explained transition probabilities. Results indicated that much of the scrub and flatwoods ecosystem was resistant to moving from a degraded state to a desired state without mechanical cutting, an expensive restoration tool. We used habitat models parameterized with the estimated transition probabilities to investigate the consequences of alternative management scenarios on future habitat dynamics. We recommend this multistate modeling approach as being broadly applicable for studying ecosystem, land cover, or habitat dynamics. The approach provides maximum-likelihood estimates of transition parameters, including precision measures, and can be used to assess

  12. Theories of Human Development that Enhance an Understanding of the College Transition Process

    ERIC Educational Resources Information Center

    Guiffrida, Douglas A.

    2009-01-01

    Background/Context: Although theories of human development often play a central role in K-12 pedagogical practices, evidence suggests that developmental theories have not been used extensively to understand the college transition process or to develop programs to support students during these transitions. Purpose/Objective/Research Question/Focus…

  13. Development of a Logic Model for a Physical Activity–Based Employee Wellness Program for Mass Transit Workers

    PubMed Central

    Petruzzello, Steven J.; Ryan, Katherine E.

    2014-01-01

    Transportation workers, who constitute a large sector of the workforce, have worksite factors that harm their health. Worksite wellness programs must target this at-risk population. Although physical activity is often a component of worksite wellness logic models, we consider it the cornerstone for improving the health of mass transit employees. Program theory was based on in-person interviews and focus groups of employees. We identified 4 short-term outcome categories, which provided a chain of responses based on the program activities that should lead to the desired end results. This logic model may have significant public health impact, because it can serve as a framework for other US mass transit districts and worksite populations that face similar barriers to wellness, including truck drivers, railroad employees, and pilots. The objective of this article is to discuss the development of a logic model for a physical activity–based mass-transit employee wellness program by describing the target population, program theory, the components of the logic model, and the process of its development. PMID:25032838

  14. Development of a logic model for a physical activity-based employee wellness program for mass transit workers.

    PubMed

    Das, Bhibha M; Petruzzello, Steven J; Ryan, Katherine E

    2014-07-17

    Transportation workers, who constitute a large sector of the workforce, have worksite factors that harm their health. Worksite wellness programs must target this at-risk population. Although physical activity is often a component of worksite wellness logic models, we consider it the cornerstone for improving the health of mass transit employees. Program theory was based on in-person interviews and focus groups of employees. We identified 4 short-term outcome categories, which provided a chain of responses based on the program activities that should lead to the desired end results. This logic model may have significant public health impact, because it can serve as a framework for other US mass transit districts and worksite populations that face similar barriers to wellness, including truck drivers, railroad employees, and pilots. The objective of this article is to discuss the development of a logic model for a physical activity-based mass-transit employee wellness program by describing the target population, program theory, the components of the logic model, and the process of its development.

  15. One-Way Deficit and Quantum Phase Transitions in XX Model

    NASA Astrophysics Data System (ADS)

    Wang, Yao-Kun; Zhang, Yu-Ran

    2018-02-01

    Quantum correlations including entanglement and quantum discord have drawn much attention in characterizing quantum phase transitions. Quantum deficit originates in questions regarding work extraction from quantum systems coupled to a heat bath (Oppenheim et al. Phys. Rev. Lett. 89, 180402, 2002). It links quantum thermodynamics with quantum correlations and provides a new standpoint for understanding quantum non-locality. In this paper, we evaluate the one-way deficit of two adjacent spins in the bulk for the XX model. In the thermodynamic limit, the XX model undergoes a first order transition from fully polarized to a critical phase with quasi-long-range order with decrease of quantum parameter. We find that the one-way deficit becomes nonzero after the critical point. Therefore, the one-way deficit characterizes the quantum phase transition in the XX model.

  16. a New Process-Oriented and Spatiotemporal Data Model for GIS Data

    NASA Astrophysics Data System (ADS)

    Shen, Y.

    2018-04-01

    With the rapid development of wireless sensor and information technology, there is a trend of transition from "digital monitoring" to "intelligence monitoring" advancing process. The traditional model cannot completely match the dynamic data to accurately describe changes of geographical and environmental changes. In this paper, we try to build a process-oriented and real-time spatiotemporal data model to meet the demands. With various types of monitoring devices, detection methods and the utilization of new technologies, the model can simulate the possible waterlog area in a specific year by analyzing the given data. By testing and modifying the spatiotemporal model, we can come to a rational conclusion that our model can forecast the actual situation in certain extent.

  17. Liquid-liquid phase transition in an ionic model of silica

    NASA Astrophysics Data System (ADS)

    Chen, Renjie; Lascaris, Erik; Palmer, Jeremy C.

    2017-06-01

    Recent equation of state calculations [E. Lascaris, Phys. Rev. Lett. 116, 125701 (2016)] for an ionic model of silica suggest that it undergoes a density-driven, liquid-liquid phase transition (LLPT) similar to the controversial transition hypothesized to exist in deeply supercooled water. Here, we perform extensive free energy calculations to scrutinize the model's low-temperature phase behavior and confirm the existence of a first-order phase transition between two liquids with identical compositions but different densities. The low-density liquid (LDL) exhibits tetrahedral order, which is partially disrupted in the high-density liquid (HDL) by the intrusion of additional particles into the primary neighbor shell. Histogram reweighting methods are applied to locate conditions of HDL-LDL coexistence and the liquid spinodals that bound the two-phase region. Spontaneous liquid-liquid phase separation is also observed directly in large-scale molecular dynamics simulations performed inside the predicted two-phase region. Given its clear LLPT, we anticipate that this model may serve as a paradigm for understanding whether similar transitions occur in water and other tetrahedral liquids.

  18. Statistical mechanics of protein structural transitions: Insights from the island model

    PubMed Central

    Kobayashi, Yukio

    2016-01-01

    The so-called island model of protein structural transition holds that hydrophobic interactions are the key to both the folding and function of proteins. Herein, the genesis and statistical mechanical basis of the island model of transitions are reviewed, by presenting the results of simulations of such transitions. Elucidating the physicochemical mechanism of protein structural formation is the foundation for understanding the hierarchical structure of life at the microscopic level. Based on the results obtained to date using the island model, remaining problems and future work in the field of protein structures are discussed, referencing Professor Saitô’s views on the hierarchic structure of science. PMID:28409078

  19. Mixed-order phase transition in a minimal, diffusion-based spin model.

    PubMed

    Fronczak, Agata; Fronczak, Piotr

    2016-07-01

    In this paper we exactly solve, within the grand canonical ensemble, a minimal spin model with the hybrid phase transition. We call the model diffusion based because its Hamiltonian can be recovered from a simple dynamic procedure, which can be seen as an equilibrium statistical mechanics representation of a biased random walk. We outline the derivation of the phase diagram of the model, in which the triple point has the hallmarks of the hybrid transition: discontinuity in the average magnetization and algebraically diverging susceptibilities. At this point, two second-order transition curves meet in equilibrium with the first-order curve, resulting in a prototypical mixed-order behavior.

  20. Solitons in Crystalline Processes; Statistical thermodynamics of structural phase transitions and mesoscopic disorder

    NASA Astrophysics Data System (ADS)

    Fujimoto, Minoru

    2017-11-01

    Solitons in Crystalline Processes is an introduction to the statistical thermodynamics of phase transitions in crystallized solids. This book is written as an introductory treatise with respect to the soliton concept, from structural transitions where the crystal symmetry changes, to magnets and superconductors, describing the role of nonlinear excitations in detail.

  1. Semi-Markov models for interval censored transient cognitive states with back transitions and a competing risk

    PubMed Central

    Wei, Shaoceng; Kryscio, Richard J.

    2015-01-01

    Continuous-time multi-state stochastic processes are useful for modeling the flow of subjects from intact cognition to dementia with mild cognitive impairment and global impairment as intervening transient, cognitive states and death as a competing risk (Figure 1). Each subject's cognition is assessed periodically resulting in interval censoring for the cognitive states while death without dementia is not interval censored. Since back transitions among the transient states are possible, Markov chains are often applied to this type of panel data. In this manuscript we apply a Semi-Markov process in which we assume that the waiting times are Weibull distributed except for transitions from the baseline state, which are exponentially distributed and in which we assume no additional changes in cognition occur between two assessments. We implement a quasi-Monte Carlo (QMC) method to calculate the higher order integration needed for likelihood estimation. We apply our model to a real dataset, the Nun Study, a cohort of 461 participants. PMID:24821001

  2. Semi-Markov models for interval censored transient cognitive states with back transitions and a competing risk.

    PubMed

    Wei, Shaoceng; Kryscio, Richard J

    2016-12-01

    Continuous-time multi-state stochastic processes are useful for modeling the flow of subjects from intact cognition to dementia with mild cognitive impairment and global impairment as intervening transient cognitive states and death as a competing risk. Each subject's cognition is assessed periodically resulting in interval censoring for the cognitive states while death without dementia is not interval censored. Since back transitions among the transient states are possible, Markov chains are often applied to this type of panel data. In this manuscript, we apply a semi-Markov process in which we assume that the waiting times are Weibull distributed except for transitions from the baseline state, which are exponentially distributed and in which we assume no additional changes in cognition occur between two assessments. We implement a quasi-Monte Carlo (QMC) method to calculate the higher order integration needed for likelihood estimation. We apply our model to a real dataset, the Nun Study, a cohort of 461 participants. © The Author(s) 2014.

  3. Ordering phase transition in the one-dimensional Axelrod model

    NASA Astrophysics Data System (ADS)

    Vilone, D.; Vespignani, A.; Castellano, C.

    2002-12-01

    We study the one-dimensional behavior of a cellular automaton aimed at the description of the formation and evolution of cultural domains. The model exhibits a non-equilibrium transition between a phase with all the system sharing the same culture and a disordered phase of coexisting regions with different cultural features. Depending on the initial distribution of the disorder the transition occurs at different values of the model parameters. This phenomenology is qualitatively captured by a mean-field approach, which maps the dynamics into a multi-species reaction-diffusion problem.

  4. Becoming Counselors through Growth and Learning: The Entry Transition Process

    ERIC Educational Resources Information Center

    Wagner, Holly H.; Hill, Nicole R.

    2015-01-01

    This article explored counselor development within the entry transition into counselor education programs using 4 interviews and interpretive dialogues with 8 beginning counselors. Six categories resulted from the authors' grounded theory analysis: Anticipation, Evolving Identity, Growth and Learning, Coping, Choosing to Trust the Process, and…

  5. Discontinuous non-equilibrium phase transition in a threshold Schloegl model for autocatalysis: Generic two-phase coexistence and metastability

    NASA Astrophysics Data System (ADS)

    Wang, Chi-Jen; Liu, Da-Jiang; Evans, James W.

    2015-04-01

    Threshold versions of Schloegl's model on a lattice, which involve autocatalytic creation and spontaneous annihilation of particles, can provide a simple prototype for discontinuous non-equilibrium phase transitions. These models are equivalent to so-called threshold contact processes. A discontinuous transition between populated and vacuum states can occur selecting a threshold of N ≥ 2 for the minimum number, N, of neighboring particles enabling autocatalytic creation at an empty site. Fundamental open questions remain given the lack of a thermodynamic framework for analysis. For a square lattice with N = 2, we show that phase coexistence occurs not at a unique value but for a finite range of particle annihilation rate (the natural control parameter). This generic two-phase coexistence also persists when perturbing the model to allow spontaneous particle creation. Such behavior contrasts both the Gibbs phase rule for thermodynamic systems and also previous analysis for this model. We find metastability near the transition corresponding to a non-zero effective line tension, also contrasting previously suggested critical behavior. Mean-field type analysis, extended to treat spatially heterogeneous states, further elucidates model behavior.

  6. Center for Modeling of Turbulence and Transition (CMOTT): Research Briefs, 1992

    NASA Technical Reports Server (NTRS)

    Liou, William W. (Editor)

    1992-01-01

    The progress is reported of the Center for Modeling of Turbulence and Transition (CMOTT). The main objective of the CMOTT is to develop, validate and implement the turbulence and transition models for practical engineering flows. The flows of interest are three-dimensional, incompressible and compressible flows with chemical reaction. The research covers two-equation (e.g., k-e) and algebraic Reynolds-stress models, second moment closure models, probability density function (pdf) models, Renormalization Group Theory (RNG), Large Eddy Simulation (LES) and Direct Numerical Simulation (DNS).

  7. Transitions amongst synchronous solutions in the stochastic Kuramoto model

    NASA Astrophysics Data System (ADS)

    DeVille, Lee

    2012-05-01

    We consider the Kuramoto model of coupled oscillators with nearest-neighbour coupling and additive white noise. We show that synchronous solutions which are stable without the addition of noise become metastable and that we have transitions amongst synchronous solutions on long timescales. We compute these timescales and, moreover, compute the most likely path in phase space that transitions will follow. We show that these transition timescales do not increase as the number of oscillators in the system increases, and are roughly constant in the system size. Finally, we show that the transitions correspond to a splitting of one synchronous solution into two communities which move independently for some time and which rejoin to form a different synchronous solution.

  8. Superresolution fluorescence imaging by pump-probe setup using repetitive stimulated transition process

    NASA Astrophysics Data System (ADS)

    Dake, Fumihiro; Fukutake, Naoki; Hayashi, Seri; Taki, Yusuke

    2018-02-01

    We proposed superresolution nonlinear fluorescence microscopy with pump-probe setup that utilizes repetitive stimulated absorption and stimulated emission caused by two-color laser beams. The resulting nonlinear fluorescence that undergoes such a repetitive stimulated transition is detectable as a signal via the lock-in technique. As the nonlinear fluorescence signal is produced by the multi-ply combination of incident beams, the optical resolution can be improved. A theoretical model of the nonlinear optical process is provided using rate equations, which offers phenomenological interpretation of nonlinear fluorescence and estimation of the signal properties. The proposed method is demonstrated as having the scalability of optical resolution. Theoretical resolution and bead image are also estimated to validate the experimental result.

  9. Phase transitions in the sdg interacting boson model

    NASA Astrophysics Data System (ADS)

    Van Isacker, P.; Bouldjedri, A.; Zerguine, S.

    2010-05-01

    A geometric analysis of the sdg interacting boson model is performed. A coherent state is used in terms of three types of deformation: axial quadrupole ( β), axial hexadecapole ( β) and triaxial ( γ). The phase-transitional structure is established for a schematic sdg Hamiltonian which is intermediate between four dynamical symmetries of U(15), namely the spherical U(5)⊗U(9), the (prolate and oblate) deformed SU(3) and the γ-soft SO(15) limits. For realistic choices of the Hamiltonian parameters the resulting phase diagram has properties close to what is obtained in the sd version of the model and, in particular, no transition towards a stable triaxial shape is found.

  10. Implementing autonomous clinical nurse specialist prescriptive authority: a competency-based transition model.

    PubMed

    Klein, Tracy Ann

    2012-01-01

    The purpose of this study was to identify and implement a competency-based regulatory model that transitions clinical nurse specialists (CNSs) to autonomous prescriptive authority pursuant to change in state law. Prescriptive authority for CNSs may be optional or restricted under current state law. Implementation of the APRN Consensus Model includes full prescriptive authority for all advanced practice registered nurses. Clinical nurse specialists face barriers to establishing their prescribing authority when laws or practice change. Identification of transition models will assist CNSs who need to add prescriptive authority to their scope of practice. Identification and implementation of a competency-based transition model for expansion of CNS prescriptive authority. By January 1, 2012, 9 CNSs in the state exemplar have completed a practicum and been granted full prescriptive authority including scheduled drug prescribing. No complaints or board actions resulted from the transition to autonomous prescribing. Transition to prescribing may be facilitated through competency-based outcomes including practicum hours as appropriate to the individual CNS nursing specialty. Outcomes from this model can be used to develop and further validate educational and credentialing policies to reduce barriers for CNSs requiring prescriptive authority in other states.

  11. Partial inertia induces additional phase transition in the majority vote model.

    PubMed

    Harunari, Pedro E; de Oliveira, M M; Fiore, C E

    2017-10-01

    Explosive (i.e., discontinuous) transitions have aroused great interest by manifesting in distinct systems, such as synchronization in coupled oscillators, percolation regime, absorbing phase transitions, and more recently, the majority-vote model with inertia. In the latter, the model rules are slightly modified by the inclusion of a term depending on the local spin (an inertial term). In such a case, Chen et al. [Phys Rev. E 95, 042304 (2017)2470-004510.1103/PhysRevE.95.042304] have found that relevant inertia changes the nature of the phase transition in complex networks, from continuous to discontinuous. Here we give a further step by embedding inertia only in vertices with degree larger than a threshold value 〈k〉k^{*}, 〈k〉 being the mean system degree and k^{*} the fraction restriction. Our results, from mean-field analysis and extensive numerical simulations, reveal that an explosive transition is presented in both homogeneous and heterogeneous structures for small and intermediate k^{*}'s. Otherwise, a large restriction can sustain a discontinuous transition only in the heterogeneous case. This shares some similarities with recent results for the Kuramoto model [Phys. Rev. E 91, 022818 (2015)PLEEE81539-375510.1103/PhysRevE.91.022818]. Surprisingly, intermediate restriction and large inertia are responsible for the emergence of an extra phase, in which the system is partially synchronized and the classification of phase transition depends on the inertia and the lattice topology. In this case, the system exhibits two phase transitions.

  12. Calibration of a γ- Re θ transition model and its application in low-speed flows

    NASA Astrophysics Data System (ADS)

    Wang, YunTao; Zhang, YuLun; Meng, DeHong; Wang, GunXue; Li, Song

    2014-12-01

    The prediction of laminar-turbulent transition in boundary layer is very important for obtaining accurate aerodynamic characteristics with computational fluid dynamic (CFD) tools, because laminar-turbulent transition is directly related to complex flow phenomena in boundary layer and separated flow in space. Unfortunately, the transition effect isn't included in today's major CFD tools because of non-local calculations in transition modeling. In this paper, Menter's γ- Re θ transition model is calibrated and incorporated into a Reynolds-Averaged Navier-Stokes (RANS) code — Trisonic Platform (TRIP) developed in China Aerodynamic Research and Development Center (CARDC). Based on the experimental data of flat plate from the literature, the empirical correlations involved in the transition model are modified and calibrated numerically. Numerical simulation for low-speed flow of Trapezoidal Wing (Trap Wing) is performed and compared with the corresponding experimental data. It is indicated that the γ- Re θ transition model can accurately predict the location of separation-induced transition and natural transition in the flow region with moderate pressure gradient. The transition model effectively imporves the simulation accuracy of the boundary layer and aerodynamic characteristics.

  13. A rigidity transition and glassy dynamics in a model for confluent 3D tissues

    NASA Astrophysics Data System (ADS)

    Merkel, Matthias; Manning, M. Lisa

    The origin of rigidity in disordered materials is an outstanding open problem in statistical physics. Recently, a new type of rigidity transition was discovered in a family of models for 2D biological tissues, but the mechanisms responsible for rigidity remain unclear. This is not just a statistical physics problem, but also relevant for embryonic development, cancer growth, and wound healing. To gain insight into this rigidity transition and make new predictions about biological bulk tissues, we have developed a fully 3D self-propelled Voronoi (SPV) model. The model takes into account shape, elasticity, and self-propelled motion of the individual cells. We find that in the absence of self-propulsion, this model exhibits a rigidity transition that is controlled by a dimensionless model parameter describing the preferred cell shape, with an accompanying structural order parameter. In the presence of self-propulsion, the rigidity transition appears as a glass-like transition featuring caging and aging effects. Given the similarities between this transition and jamming in particulate solids, it is natural to ask if the two transitions are related. By comparing statistics of Voronoi geometries, we show the transitions are surprisingly close but demonstrably distinct. Furthermore, an index theorem used to identify topologically protected mechanical modes in jammed systems can be extended to these vertex-type models. In our model, residual stresses govern the transition and enter the index theorem in a different way compared to jammed particles, suggesting the origin of rigidity may be different between the two.

  14. Implementation of polarization processes in a charge transport model applied on poly(ethylene naphthalate) films

    NASA Astrophysics Data System (ADS)

    Hoang, M.-Q.; Le Roy, S.; Boudou, L.; Teyssedre, G.

    2016-06-01

    One of the difficulties in unravelling transport processes in electrically insulating materials is the fact that the response, notably charging current transients, can have mixed contributions from orientation polarization and from space charge processes. This work aims at identifying and characterizing the polarization processes in a polar polymer in the time and frequency-domains and to implement the contribution of the polarization into a charge transport model. To do so, Alternate Polarization Current (APC) and Dielectric Spectroscopy measurements have been performed on poly(ethylene naphthalene 2,6-dicarboxylate) (PEN), an aromatic polar polymer, providing information on polarization mechanisms in the time- and frequency-domain, respectively. In the frequency-domain, PEN exhibits 3 relaxation processes termed β, β* (sub-glass transitions), and α relaxations (glass transition) in increasing order of temperature. Conduction was also detected at high temperatures. Dielectric responses were treated using a simplified version of the Havriliak-Negami model (Cole-Cole (CC) model), using 3 parameters per relaxation process, these parameters being temperature dependent. The time dependent polarization obtained from the CC model is then added to a charge transport model. Simulated currents issued from the transport model implemented with the polarization are compared with the measured APCs, showing a good consistency between experiments and simulations in a situation where the response comes essentially from dipolar processes.

  15. Transition from coherence to bistability in a model of financial markets

    NASA Astrophysics Data System (ADS)

    D'Hulst, R.; Rodgers, G. J.

    2001-04-01

    We present a model describing the competition between information transmission and decision making in financial markets. The solution of this simple model is recalled, and possible variations discussed. It is shown numerically that despite its simplicity, it can mimic a size effect comparable to a crash localized in time. Two extensions of this model are presented that allow to simulate the demand process. One of these extensions has a coherent stable equilibrium and is self-organized, while the other has a bistable equilibrium, with a spontaneous segregation of the population of agents. A new model is introduced to generate a transition between those two equilibriums. We show that the coherent state is dominant up to an equal mixing of the two extensions. We focus our attention on the microscopic structure of the investment rate, which is the main parameter of the original model. A constant investment rate seems to be a very good approximation.

  16. Live Imaging-Based Model Selection Reveals Periodic Regulation of the Stochastic G1/S Phase Transition in Vertebrate Axial Development

    PubMed Central

    Kurokawa, Hiroshi; Sakaue-Sawano, Asako; Imamura, Takeshi; Miyawaki, Atsushi; Iimura, Tadahiro

    2014-01-01

    In multicellular organism development, a stochastic cellular response is observed, even when a population of cells is exposed to the same environmental conditions. Retrieving the spatiotemporal regulatory mode hidden in the heterogeneous cellular behavior is a challenging task. The G1/S transition observed in cell cycle progression is a highly stochastic process. By taking advantage of a fluorescence cell cycle indicator, Fucci technology, we aimed to unveil a hidden regulatory mode of cell cycle progression in developing zebrafish. Fluorescence live imaging of Cecyil, a zebrafish line genetically expressing Fucci, demonstrated that newly formed notochordal cells from the posterior tip of the embryonic mesoderm exhibited the red (G1) fluorescence signal in the developing notochord. Prior to their initial vacuolation, these cells showed a fluorescence color switch from red to green, indicating G1/S transitions. This G1/S transition did not occur in a synchronous manner, but rather exhibited a stochastic process, since a mixed population of red and green cells was always inserted between newly formed red (G1) notochordal cells and vacuolating green cells. We termed this mixed population of notochordal cells, the G1/S transition window. We first performed quantitative analyses of live imaging data and a numerical estimation of the probability of the G1/S transition, which demonstrated the existence of a posteriorly traveling regulatory wave of the G1/S transition window. To obtain a better understanding of this regulatory mode, we constructed a mathematical model and performed a model selection by comparing the results obtained from the models with those from the experimental data. Our analyses demonstrated that the stochastic G1/S transition window in the notochord travels posteriorly in a periodic fashion, with doubled the periodicity of the neighboring paraxial mesoderm segmentation. This approach may have implications for the characterization of the

  17. Graduation Day: Healthcare Transition From Pediatric to Adult.

    PubMed

    Green Corkins, Kelly; Miller, Michelle A; Whitworth, John R; McGinnis, Carol

    2018-02-01

    Because more patients with pediatric-onset chronic conditions are surviving into adulthood, they are graduating from pediatric healthcare to self-management and adult healthcare. This transfer of care needs to be a process of transitioning medical and nutrition care. Despite having position statements from professional organizations and several proposed models, issues in the transition process have been well described, and gaps in transition care persist. Healthcare providers need to be aware of special needs of emerging adults related to education on chronic condition and self-management skills, emotional support before and after transition, and legal rights for both the patient and the parent if the emerging adult is not developmentally appropriate to make his or her own healthcare decisions. Both pediatric and adult providers need to be in active communication with each other and the patient to develop trusting relationships and actively support the transition of care. This review of literature describes several models for transitioning, measureable outcomes, insurance provider issues, and legal issues pertaining to healthcare transition. © 2018 American Society for Parenteral and Enteral Nutrition.

  18. Transitivity vs. intransitivity in decision making process - an example in quantum game theory

    NASA Astrophysics Data System (ADS)

    Makowski, Marcin

    2009-06-01

    We compare two different ways of quantum modification in a simple sequential game called Cat's Dilemma in the context of the debate on intransitive and transitive preferences. This kind of analysis can have essential meaning for research on artificial intelligence (some possibilities are discussed). Nature has both transitive and intransitive properties and perhaps quantum models will be more able to capture this dualism than the classical models. We also present an electoral interpretation of the game.

  19. RNA-sequencing elucidates the regulation of behavioural transitions associated with the mating process in honey bee queens.

    PubMed

    Manfredini, Fabio; Brown, Mark J F; Vergoz, Vanina; Oldroyd, Benjamin P

    2015-07-31

    Mating is a complex process, which is frequently associated with behavioural and physiological changes. However, understanding of the genetic underpinnings of these changes is limited. Honey bees are both a model system in behavioural genomics, and the dominant managed pollinator of human crops; consequently understanding the mating process has both pure and applied value. We used next-generation transcriptomics to probe changes in gene expression in the brains of honey bee queens, as they transition from virgin to mated reproductive status. In addition, we used CO2-narcosis, which induces oviposition without mating, to isolate the process of reproductive maturation. The mating process produced significant changes in the expression of vision, chemo-reception, metabolic, and immune-related genes. Differential expression of these genes maps clearly onto known behavioural and physiological changes that occur during the transition from being a virgin queen to a newly-mated queen. A subset of these changes in gene expression were also detected in CO2-treated queens, as predicted from previous physiological studies. In addition, we compared our results to previous studies that used microarray techniques across a range of experimental time-points. Changes in expression of immune- and vision-related genes were common to all studies, supporting an involvement of these groups of genes in the mating process. Our study is an important step in understanding the molecular mechanisms regulating post-mating behavioural transitions in a natural system. The weak overlap in patterns of gene expression with previous studies demonstrates the high sensitivity of genome-wide approaches. Thus, while we build on previous microarray studies that explored post-mating changes in honey bees, the broader experimental design, use of RNA-sequencing, and focus on Australian honey bees, which remain free from the devastating parasite Varroa destructor, in the current study, provide unique insights

  20. Application of fracture toughness scaling models to the ductile-to- brittle transition

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Link, R.E.; Joyce, J.A.

    1996-01-01

    An experimental investigation of fracture toughness in the ductile-brittle transition range was conducted. A large number of ASTM A533, Grade B steel, bend and tension specimens with varying crack lengths were tested throughout the transition region. Cleavage fracture toughness scaling models were utilized to correct the data for the loss of constraint in short crack specimens and tension geometries. The toughness scaling models were effective in reducing the scatter in the data, but tended to over-correct the results for the short crack bend specimens. A proposed ASTM Test Practice for Fracture Toughness in the Transition Range, which employs a mastermore » curve concept, was applied to the results. The proposed master curve over predicted the fracture toughness in the mid-transition and a modified master curve was developed that more accurately modeled the transition behavior of the material. Finally, the modified master curve and the fracture toughness scaling models were combined to predict the as-measured fracture toughness of the short crack bend and the tension specimens. It was shown that when the scaling models over correct the data for loss of constraint, they can also lead to non-conservative estimates of the increase in toughness for low constraint geometries.« less

  1. An interactive quality of work life model applied to organizational transition.

    PubMed

    Knox, S; Irving, J A

    1997-01-01

    Most healthcare organizations in the United States are in the process of some type of organizational change or transition. Professional nurses and other healthcare providers practicing in U.S. healthcare delivery organizations are very aware of the dramatic effects of restructuring processes. A phenomenal amount of change and concern is occurring with organizational redesign, generating many questions and uncertainties. These transitions challenge the basic assumptions and principles guiding the practice of clinical and management roles in healthcare.

  2. Adding Structure to the Transition Process to Advanced Mathematical Activity

    ERIC Educational Resources Information Center

    Engelbrecht, Johann

    2010-01-01

    The transition process to advanced mathematical thinking is experienced as traumatic by many students. Experiences that students had of school mathematics differ greatly to what is expected from them at university. Success in school mathematics meant application of different methods to get an answer. Students are not familiar with logical…

  3. Skin Friction and Transition Location Measurement on Supersonic Transport Models

    NASA Technical Reports Server (NTRS)

    Kennelly, Robert A., Jr.; Goodsell, Aga M.; Olsen, Lawrence E. (Technical Monitor)

    2000-01-01

    Flow visualization techniques were used to obtain both qualitative and quantitative skin friction and transition location data in wind tunnel tests performed on two supersonic transport models at Mach 2.40. Oil-film interferometry was useful for verifying boundary layer transition, but careful monitoring of model surface temperatures and systematic examination of the effects of tunnel start-up and shutdown transients will be required to achieve high levels of accuracy for skin friction measurements. A more common technique, use of a subliming solid to reveal transition location, was employed to correct drag measurements to a standard condition of all-turbulent flow on the wing. These corrected data were then analyzed to determine the additional correction required to account for the effect of the boundary layer trip devices.

  4. Network inoculation: Heteroclinics and phase transitions in an epidemic model

    NASA Astrophysics Data System (ADS)

    Yang, Hui; Rogers, Tim; Gross, Thilo

    2016-08-01

    In epidemiological modelling, dynamics on networks, and, in particular, adaptive and heterogeneous networks have recently received much interest. Here, we present a detailed analysis of a previously proposed model that combines heterogeneity in the individuals with adaptive rewiring of the network structure in response to a disease. We show that in this model, qualitative changes in the dynamics occur in two phase transitions. In a macroscopic description, one of these corresponds to a local bifurcation, whereas the other one corresponds to a non-local heteroclinic bifurcation. This model thus provides a rare example of a system where a phase transition is caused by a non-local bifurcation, while both micro- and macro-level dynamics are accessible to mathematical analysis. The bifurcation points mark the onset of a behaviour that we call network inoculation. In the respective parameter region, exposure of the system to a pathogen will lead to an outbreak that collapses but leaves the network in a configuration where the disease cannot reinvade, despite every agent returning to the susceptible class. We argue that this behaviour and the associated phase transitions can be expected to occur in a wide class of models of sufficient complexity.

  5. Validation of a RANS transition model using a high-order weighted compact nonlinear scheme

    NASA Astrophysics Data System (ADS)

    Tu, GuoHua; Deng, XiaoGang; Mao, MeiLiang

    2013-04-01

    A modified transition model is given based on the shear stress transport (SST) turbulence model and an intermittency transport equation. The energy gradient term in the original model is replaced by flow strain rate to saving computational costs. The model employs local variables only, and then it can be conveniently implemented in modern computational fluid dynamics codes. The fifth-order weighted compact nonlinear scheme and the fourth-order staggered scheme are applied to discrete the governing equations for the purpose of minimizing discretization errors, so as to mitigate the confusion between numerical errors and transition model errors. The high-order package is compared with a second-order TVD method on simulating the transitional flow of a flat plate. Numerical results indicate that the high-order package give better grid convergence property than that of the second-order method. Validation of the transition model is performed for transitional flows ranging from low speed to hypersonic speed.

  6. Modeling the hepatitis A epidemiological transition in Brazil and Mexico.

    PubMed

    Van Effelterre, Thierry; Guignard, Adrienne; Marano, Cinzia; Rojas, Rosalba; Jacobsen, Kathryn H

    2017-08-03

    Many low- to middle-income countries have completed or are in the process of transitioning from high or intermediate to low endemicity for hepatitis A virus (HAV). Because the risk of severe hepatitis A disease increases with age at infection, decreased incidence that leaves older children and adults susceptible to HAV infection may actually increase the population-level burden of disease from HAV. Mathematical models can be helpful for projecting future epidemiological profiles for HAV. An age-specific deterministic, dynamic compartmental transmission model with stratification by setting (rural versus urban) was calibrated with country-specific data on demography, urbanization, and seroprevalence of anti-HAV antibodies. HAV transmission was modeled as a function of setting-specific access to safe water. The model was then used to project various HAV-related epidemiological outcomes in Brazil and in Mexico from 1950 to 2050. The projected epidemiological outcomes were qualitatively similar in the 2 countries. The age at the midpoint of population immunity (AMPI) increased considerably and the mean age of symptomatic HAV cases shifted from childhood to early adulthood. The projected overall incidence rate of HAV infections decreased by about two thirds as safe water access improved. However, the incidence rate of symptomatic HAV infections remained roughly the same over the projection period. The incidence rates of HAV infections (all and symptomatic alone) were projected to become similar in rural and urban settings in the next decades. This model featuring population age structure, urbanization and access to safe water as key contributors to the epidemiological transition for HAV was previously validated with data from Thailand and fits equally well with data from Latin American countries. Assuming no introduction of a vaccination program over the projection period, both Brazil and Mexico were projected to experience a continued decrease in HAV incidence rates

  7. Modeling Developmental Transitions in Adaptive Resonance Theory

    ERIC Educational Resources Information Center

    Raijmakers, Maartje E. J.; Molenaar, Peter C. M.

    2004-01-01

    Neural networks are applied to a theoretical subject in developmental psychology: modeling developmental transitions. Two issues that are involved will be discussed: discontinuities and acquiring qualitatively new knowledge. We will argue that by the appearance of a bifurcation, a neural network can show discontinuities and may acquire…

  8. ISS-Experiments of Columnar-to-Equiaxed Transition in Solidification Processing

    NASA Technical Reports Server (NTRS)

    Sturz, Laszlo; Zimmermann, Gerhard; Gandin, Charles, Andre; Billia, Bernard; Magelinck, Nathalie; Nguyen-Thi, Henry; Browne, David John; Mirihanage, Wajira U.; Voss, Daniela; Beckermann, Christoph; hide

    2012-01-01

    The main topic of the research project CETSOL in the framework of the Microgravity Application Promotion (MAP) programme of the European Space Agency (ESA) is the investigation of the transition from columnar to equiaxed grain growth during solidification. Microgravity environment allows for suppression of buoyancy-driven melt flow and for growth of equiaxed grains free of sedimentation and buoyancy effects. This contribution will present first experimental results obtained in microgravity using hypo-eutectic AlSi alloys in the Materials Science Laboratory (MSL) on-board the International Space Station (ISS). The analysis of the experiments confirms the existence of a columnar to equiaxed transition, especially in the refined alloy. Temperature evolution and grain structure analysis provide critical values for the position, the temperature gradient and the solidification velocity at the columnar to equiaxed transition. These data will be used to improve modeling of solidification microstructures and grain structure on different lengths scales.

  9. Transition probabilities for general birth-death processes with applications in ecology, genetics, and evolution

    PubMed Central

    Crawford, Forrest W.; Suchard, Marc A.

    2011-01-01

    A birth-death process is a continuous-time Markov chain that counts the number of particles in a system over time. In the general process with n current particles, a new particle is born with instantaneous rate λn and a particle dies with instantaneous rate μn. Currently no robust and efficient method exists to evaluate the finite-time transition probabilities in a general birth-death process with arbitrary birth and death rates. In this paper, we first revisit the theory of continued fractions to obtain expressions for the Laplace transforms of these transition probabilities and make explicit an important derivation connecting transition probabilities and continued fractions. We then develop an efficient algorithm for computing these probabilities that analyzes the error associated with approximations in the method. We demonstrate that this error-controlled method agrees with known solutions and outperforms previous approaches to computing these probabilities. Finally, we apply our novel method to several important problems in ecology, evolution, and genetics. PMID:21984359

  10. Discontinuous non-equilibrium phase transition in a threshold Schloegl model for autocatalysis: Generic two-phase coexistence and metastability

    DOE PAGES

    Wang, Chi -Jen; Liu, Da -Jiang; Evans, James W.

    2015-04-28

    Threshold versions of Schloegl’s model on a lattice, which involve autocatalytic creation and spontaneous annihilation of particles, can provide a simple prototype for discontinuous non-equilibrium phase transitions. These models are equivalent to so-called threshold contact processes. A discontinuous transition between populated and vacuum states can occur selecting a threshold of N ≥ 2 for the minimum number, N, of neighboring particles enabling autocatalytic creation at an empty site. Fundamental open questions remain given the lack of a thermodynamic framework for analysis. For a square lattice with N = 2, we show that phase coexistence occurs not at a unique valuemore » but for a finite range of particle annihilation rate (the natural control parameter). This generic two-phase coexistence also persists when perturbing the model to allow spontaneous particle creation. Such behavior contrasts both the Gibbs phase rule for thermodynamic systems and also previous analysis for this model. We find metastability near the transition corresponding to a non-zero effective line tension, also contrasting previously suggested critical behavior. As a result, mean-field type analysis, extended to treat spatially heterogeneous states, further elucidates model behavior.« less

  11. Spectral properties near the Mott transition in the two-dimensional Hubbard model

    NASA Astrophysics Data System (ADS)

    Kohno, Masanori

    2013-03-01

    Single-particle excitations near the Mott transition in the two-dimensional (2D) Hubbard model are investigated by using cluster perturbation theory. The Mott transition is characterized by the loss of the spectral weight from the dispersing mode that leads continuously to the spin-wave excitation of the Mott insulator. The origins of the dominant modes of the 2D Hubbard model near the Mott transition can be traced back to those of the one-dimensional Hubbard model. Various anomalous spectral features observed in cuprate high-temperature superconductors, such as the pseudogap, Fermi arc, flat band, doping-induced states, hole pockets, and spinon-like and holon-like branches, as well as giant kink and waterfall in the dispersion relation, are explained in a unified manner as properties near the Mott transition in a 2D system.

  12. Measurements of Rationality: Individual Differences in Information Processing, the Transitivity of Preferences and Decision Strategies

    PubMed Central

    Sleboda, Patrycja; Sokolowska, Joanna

    2017-01-01

    The first goal of this study was to validate the Rational-Experiential Inventory (REI) and the Cognitive Reflection Test (CRT) through checking their relation to the transitivity axiom. The second goal was to test the relation between decision strategies and cognitive style as well as the relation between decision strategies and the transitivity of preferences. The following characteristics of strategies were investigated: requirements for trade-offs, maximization vs. satisficing and option-wise vs. attribute-wise information processing. Respondents were given choices between two multi-attribute options. The options were designed so that the choice indicated which strategy was applied. Both the REI-R and the CRT were found to be good predictors of the transitivity of preferences. Respondents who applied compensatory strategies and the maximization criterion scored highly on the REI-R and in the CRT, whereas those who applied the satisficing rule scored highly on the REI-R but not in the CRT. Attribute-wise information processing was related to low scores in both measurements. Option-wise information processing led to a high transitivity of preferences. PMID:29093695

  13. Measurements of Rationality: Individual Differences in Information Processing, the Transitivity of Preferences and Decision Strategies.

    PubMed

    Sleboda, Patrycja; Sokolowska, Joanna

    2017-01-01

    The first goal of this study was to validate the Rational-Experiential Inventory ( REI ) and the Cognitive Reflection Test ( CRT ) through checking their relation to the transitivity axiom. The second goal was to test the relation between decision strategies and cognitive style as well as the relation between decision strategies and the transitivity of preferences. The following characteristics of strategies were investigated: requirements for trade-offs, maximization vs. satisficing and option-wise vs. attribute-wise information processing. Respondents were given choices between two multi-attribute options. The options were designed so that the choice indicated which strategy was applied. Both the REI-R and the CRT were found to be good predictors of the transitivity of preferences. Respondents who applied compensatory strategies and the maximization criterion scored highly on the REI-R and in the CRT , whereas those who applied the satisficing rule scored highly on the REI-R but not in the CRT . Attribute-wise information processing was related to low scores in both measurements. Option-wise information processing led to a high transitivity of preferences.

  14. Cell reprogramming modelled as transitions in a hierarchy of cell cycles

    NASA Astrophysics Data System (ADS)

    Hannam, Ryan; Annibale, Alessia; Kühn, Reimer

    2017-10-01

    We construct a model of cell reprogramming (the conversion of fully differentiated cells to a state of pluripotency, known as induced pluripotent stem cells, or iPSCs) which builds on key elements of cell biology viz. cell cycles and cell lineages. Although reprogramming has been demonstrated experimentally, much of the underlying processes governing cell fate decisions remain unknown. This work aims to bridge this gap by modelling cell types as a set of hierarchically related dynamical attractors representing cell cycles. Stages of the cell cycle are characterised by the configuration of gene expression levels, and reprogramming corresponds to triggering transitions between such configurations. Two mechanisms were found for reprogramming in a two level hierarchy: cycle specific perturbations and a noise induced switching. The former corresponds to a directed perturbation that induces a transition into a cycle-state of a different cell type in the potency hierarchy (mainly a stem cell) whilst the latter is a priori undirected and could be induced, e.g. by a (stochastic) change in the cellular environment. These reprogramming protocols were found to be effective in large regimes of the parameter space and make specific predictions concerning reprogramming dynamics which are broadly in line with experimental findings.

  15. Methods used to parameterize the spatially-explicit components of a state-and-transition simulation model

    USGS Publications Warehouse

    Sleeter, Rachel; Acevedo, William; Soulard, Christopher E.; Sleeter, Benjamin M.

    2015-01-01

    Spatially-explicit state-and-transition simulation models of land use and land cover (LULC) increase our ability to assess regional landscape characteristics and associated carbon dynamics across multiple scenarios. By characterizing appropriate spatial attributes such as forest age and land-use distribution, a state-and-transition model can more effectively simulate the pattern and spread of LULC changes. This manuscript describes the methods and input parameters of the Land Use and Carbon Scenario Simulator (LUCAS), a customized state-and-transition simulation model utilized to assess the relative impacts of LULC on carbon stocks for the conterminous U.S. The methods and input parameters are spatially explicit and describe initial conditions (strata, state classes and forest age), spatial multipliers, and carbon stock density. Initial conditions were derived from harmonization of multi-temporal data characterizing changes in land use as well as land cover. Harmonization combines numerous national-level datasets through a cell-based data fusion process to generate maps of primary LULC categories. Forest age was parameterized using data from the North American Carbon Program and spatially-explicit maps showing the locations of past disturbances (i.e. wildfire and harvest). Spatial multipliers were developed to spatially constrain the location of future LULC transitions. Based on distance-decay theory, maps were generated to guide the placement of changes related to forest harvest, agricultural intensification/extensification, and urbanization. We analyze the spatially-explicit input parameters with a sensitivity analysis, by showing how LUCAS responds to variations in the model input. This manuscript uses Mediterranean California as a regional subset to highlight local to regional aspects of land change, which demonstrates the utility of LUCAS at many scales and applications.

  16. Transition sum rules in the shell model

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lu, Yi; Johnson, Calvin W.

    An important characterization of electromagnetic and weak transitions in atomic nuclei are sum rules. We focus on the non-energy-weighted sum rule (NEWSR), or total strength, and the energy- weighted sum rule (EWSR); the ratio of the EWSR to the NEWSR is the centroid or average energy of transition strengths from an nuclear initial state to all allowed final states. These sum rules can be expressed as expectation values of operators, in the case of the EWSR a double commutator. While most prior applications of the double-commutator have been to special cases, we derive general formulas for matrix elements of bothmore » operators in a shell model framework (occupation space), given the input matrix elements for the nuclear Hamiltonian and for the transition operator. With these new formulas, we easily evaluate centroids of transition strength functions, with no need to calculate daughter states. We then apply this simple tool to a number of nuclides, and demonstrate the sum rules follow smooth secular behavior as a function of initial energy, as well as compare the electric dipole (E1) sum rule against the famous Thomas-Reiche-Kuhn version. We also find surprising systematic behaviors for ground state electric quadrupole (E2) centroids in the $sd$-shell.« less

  17. Transition sum rules in the shell model

    DOE PAGES

    Lu, Yi; Johnson, Calvin W.

    2018-03-29

    An important characterization of electromagnetic and weak transitions in atomic nuclei are sum rules. We focus on the non-energy-weighted sum rule (NEWSR), or total strength, and the energy- weighted sum rule (EWSR); the ratio of the EWSR to the NEWSR is the centroid or average energy of transition strengths from an nuclear initial state to all allowed final states. These sum rules can be expressed as expectation values of operators, in the case of the EWSR a double commutator. While most prior applications of the double-commutator have been to special cases, we derive general formulas for matrix elements of bothmore » operators in a shell model framework (occupation space), given the input matrix elements for the nuclear Hamiltonian and for the transition operator. With these new formulas, we easily evaluate centroids of transition strength functions, with no need to calculate daughter states. We then apply this simple tool to a number of nuclides, and demonstrate the sum rules follow smooth secular behavior as a function of initial energy, as well as compare the electric dipole (E1) sum rule against the famous Thomas-Reiche-Kuhn version. We also find surprising systematic behaviors for ground state electric quadrupole (E2) centroids in the $sd$-shell.« less

  18. Transition sum rules in the shell model

    NASA Astrophysics Data System (ADS)

    Lu, Yi; Johnson, Calvin W.

    2018-03-01

    An important characterization of electromagnetic and weak transitions in atomic nuclei are sum rules. We focus on the non-energy-weighted sum rule (NEWSR), or total strength, and the energy-weighted sum rule (EWSR); the ratio of the EWSR to the NEWSR is the centroid or average energy of transition strengths from an nuclear initial state to all allowed final states. These sum rules can be expressed as expectation values of operators, which in the case of the EWSR is a double commutator. While most prior applications of the double commutator have been to special cases, we derive general formulas for matrix elements of both operators in a shell model framework (occupation space), given the input matrix elements for the nuclear Hamiltonian and for the transition operator. With these new formulas, we easily evaluate centroids of transition strength functions, with no need to calculate daughter states. We apply this simple tool to a number of nuclides and demonstrate the sum rules follow smooth secular behavior as a function of initial energy, as well as compare the electric dipole (E 1 ) sum rule against the famous Thomas-Reiche-Kuhn version. We also find surprising systematic behaviors for ground-state electric quadrupole (E 2 ) centroids in the s d shell.

  19. Towards a Sufficient Theory of Transition in Cognitive Development.

    ERIC Educational Resources Information Center

    Wallace, J. G.

    The work reported aims at the construction of a sufficient theory of transition in cognitive development. The method of theory construction employed is computer simulation of cognitive process. The core of the model of transition presented comprises self-modification processes that, as a result of continuously monitoring an exhaustive record of…

  20. Center for Modeling of Turbulence and Transition (CMOTT). Research briefs: 1990

    NASA Technical Reports Server (NTRS)

    Povinelli, Louis A. (Compiler); Liou, Meng-Sing (Compiler); Shih, Tsan-Hsing (Compiler)

    1991-01-01

    Brief progress reports of the Center for Modeling of Turbulence and Transition (CMOTT) research staff from May 1990 to May 1991 are given. The objectives of the CMOTT are to develop, validate, and implement the models for turbulence and boundary layer transition in the practical engineering flows. The flows of interest are three dimensional, incompressible, and compressible flows with chemistry. The schemes being studied include the two-equation and algebraic Reynolds stress models, the full Reynolds stress (or second moment closure) models, the probability density function models, the Renormalization Group Theory (RNG) and Interaction Approximation (DIA), the Large Eddy Simulation (LES) and Direct Numerical Simulation (DNS).

  1. Promoting School Psychologist Participation in Transition Services Using the TPIE Model

    ERIC Educational Resources Information Center

    Talapatra, Devadrita; Roach, Andrew T.; Varjas, Kris; Houchins, David E.; Crimmins, Daniel B.

    2018-01-01

    Transition services can be used to forge family, school, and community partnerships and foster a successful shift to adult life for students with intellectual disabilities (ID). School psychologists can play a valuable additive role in supporting the transition process due to their graduate training in interpersonal skills; consultation services;…

  2. Modeling texture kinetics during thermal processing of potato products.

    PubMed

    Moyano, P C; Troncoso, E; Pedreschi, F

    2007-03-01

    A kinetic model based on 2 irreversible serial chemical reactions has been proposed to fit experimental data of texture changes during thermal processing of potato products. The model links dimensionless maximum force F*(MAX) with processing time. Experimental texture changes were obtained during frying of French fries and potato chips at different temperatures, while literature data for blanching/cooking of potato cubes have been considered. A satisfactory agreement between experimental and predicted values was observed, with root mean square values (RMSs) in the range of 4.7% to 16.4% for French fries and 16.7% to 29.3% for potato chips. In the case of blanching/cooking, the proposed model gave RMSs in the range of 1.2% to 17.6%, much better than the 6.2% to 44.0% obtained with the traditional 1st-order kinetics. The model is able to predict likewise the transition from softening to hardening of the tissue during frying.

  3. A Career and Learning Transitional Model for Those Experiencing Labour Market Disadvantage

    ERIC Educational Resources Information Center

    Cameron, Roslyn

    2009-01-01

    Research investigating the learning and career transitions of those disadvantaged in the labour market has resulted in the development of a four-component model to enable disadvantaged groups to navigate learning and career transitions. The four components of the model include: the self-concept; learning and recognition; career and life planning;…

  4. Modeling the solid-liquid phase transition in saturated triglycerides

    NASA Astrophysics Data System (ADS)

    Pink, David A.; Hanna, Charles B.; Sandt, Christophe; MacDonald, Adam J.; MacEachern, Ronald; Corkery, Robert; Rousseau, Dérick

    2010-02-01

    We investigated theoretically two competing published scenarios for the melting transition of the triglyceride trilaurin (TL): those of (1) Corkery et al. [Langmuir 23, 7241 (2007)], in which the average state of each TL molecule in the liquid phase is a discotic "Y" conformer whose three chains are dynamically twisted, with an average angle of ˜120° between them, and those of (2) Cebula et al. [J. Am. Oil Chem. Soc. 69, 130 (1992)], in which the liquid-state conformation of the TL molecule in the liquid phase is a nematic h∗-conformer whose three chains are in a modified "chair" conformation. We developed two competing models for the two scenarios, in which TL molecules are in a nematic compact-chair (or "h") conformation, with extended, possibly all-trans, chains at low-temperatures, and in either a Y conformation or an h∗ conformation in the liquid state at temperatures higher than the phase-transition temperature, T∗=319 K. We defined an h-Y model as a realization of the proposal of Corkery et al. [Langmuir 23, 7241 (2007)], and explored its predictions by mapping it onto an Ising model in a temperature-dependent field, performing a mean-field approximation, and calculating the transition enthalpy ΔH. We found that the most plausible realization of the h-Y model, as applied to the solid-liquid phase transition in TL, and likely to all saturated triglycerides, gave a value of ΔH in reasonable agreement with the experiment. We then defined an alternative h-h∗ model as a realization of the proposal of Cebula et al. [J. Am. Oil Chem. Soc. 69, 130 (1992)], in which the liquid phase exhibits an average symmetry breaking similar to an h conformation, but with twisted chains, to see whether it could describe the TL phase transition. The h-h∗ model gave a value of ΔH that was too small by a factor of ˜3-4. We also predicted the temperature dependence of the 1132 cm-1 Raman band for both models, and performed measurements of the ratios of three TL Raman

  5. Assessing the effects of rural livelihood transition on non-point source pollution: a coupled ABM-IECM model.

    PubMed

    Yuan, Chengcheng; Liu, Liming; Ye, Jinwei; Ren, Guoping; Zhuo, Dong; Qi, Xiaoxing

    2017-05-01

    Water pollution caused by anthropogenic activities and driven by changes in rural livelihood strategies in an agricultural system has received increasing attention in recent decades. To simulate the effects of rural household livelihood transition on non-point source (NPS) pollution, a model combining an agent-based model (ABM) and an improved export coefficient model (IECM) was developed. The ABM was adopted to simulate the dynamic process of household livelihood transition, and the IECM was employed to estimate the effects of household livelihood transition on NPS pollution. The coupled model was tested in a small catchment in the Dongting Lake region, China. The simulated results reveal that the transition of household livelihood strategies occurred with the changes in the prices of rice, pig, and labor. Thus, the cropping system, land-use intensity, resident population, and number of pigs changed in the small catchment from 2000 to 2014. As a result of these changes, the total nitrogen load discharged into the river initially increased from 6841.0 kg in 2000 to 8446.3 kg in 2004 and then decreased to 6063.9 kg in 2014. Results also suggest that rural living, livestock, paddy field, and precipitation alternately became the main causes of NPS pollution in the small catchment, and the midstream region of the small catchment was the primary area for NPS pollution from 2000 to 2014. Despite some limitations, the coupled model provides an innovative way to simulate the effects of rural household livelihood transition on NPS pollution with the change of socioeconomic factors, and thereby identify the key factors influencing water pollution to provide valuable suggestions on how agricultural environmental risks can be reduced through the regulation of the behaviors of farming households in the future.

  6. A Closed-Loop Model of Operator Visual Attention, Situation Awareness, and Performance Across Automation Mode Transitions.

    PubMed

    Johnson, Aaron W; Duda, Kevin R; Sheridan, Thomas B; Oman, Charles M

    2017-03-01

    This article describes a closed-loop, integrated human-vehicle model designed to help understand the underlying cognitive processes that influenced changes in subject visual attention, mental workload, and situation awareness across control mode transitions in a simulated human-in-the-loop lunar landing experiment. Control mode transitions from autopilot to manual flight may cause total attentional demands to exceed operator capacity. Attentional resources must be reallocated and reprioritized, which can increase the average uncertainty in the operator's estimates of low-priority system states. We define this increase in uncertainty as a reduction in situation awareness. We present a model built upon the optimal control model for state estimation, the crossover model for manual control, and the SEEV (salience, effort, expectancy, value) model for visual attention. We modify the SEEV attention executive to direct visual attention based, in part, on the uncertainty in the operator's estimates of system states. The model was validated using the simulated lunar landing experimental data, demonstrating an average difference in the percentage of attention ≤3.6% for all simulator instruments. The model's predictions of mental workload and situation awareness, measured by task performance and system state uncertainty, also mimicked the experimental data. Our model supports the hypothesis that visual attention is influenced by the uncertainty in system state estimates. Conceptualizing situation awareness around the metric of system state uncertainty is a valuable way for system designers to understand and predict how reallocations in the operator's visual attention during control mode transitions can produce reallocations in situation awareness of certain states.

  7. M1 transitions in the (sdg) boson model

    NASA Astrophysics Data System (ADS)

    Kuyucak, S.; Morrison, I.

    1988-03-01

    Using the {1}/{N} expansion technique we derive expressions for β→g, γ→g and γ→γ M1 transitions in a general boson model. The M1 matrix elements in the sdg-boson model are similar in form to those in the neutron-proton IBM. Comparisons are made to some selected M1 data exhibiting collective character.

  8. Van der Waals model for phase transitions in thermoresponsive surface films.

    PubMed

    McCoy, John D; Curro, John G

    2009-05-21

    Phase transitions in polymeric surface films are studied with a simple model based on the van der Waals equation of state. Each chain is modeled by a single bead attached to the surface by an entropic-Hooke's law spring. The surface coverage is controlled by adjusting the chemical potential, and the equilibrium density profile is calculated with density functional theory. The interesting feature of this model is the multivalued nature of the density profile seen at low temperature. This van der Waals loop behavior is resolved with a Maxwell construction between a high-density phase near the wall and a low-density phase in a "vertical" phase transition. Signatures of the phase transition in experimentally measurable quantities are then found. Numerical calculations are presented for isotherms of surface pressure, for the Poisson ratio, and for the swelling ratio.

  9. Effects of ignoring baseline on modeling transitions from intact cognition to dementia.

    PubMed

    Yu, Lei; Tyas, Suzanne L; Snowdon, David A; Kryscio, Richard J

    2009-07-01

    This paper evaluates the effect of ignoring baseline when modeling transitions from intact cognition to dementia with mild cognitive impairment (MCI) and global impairment (GI) as intervening cognitive states. Transitions among states are modeled by a discrete-time Markov chain having three transient (intact cognition, MCI, and GI) and two competing absorbing states (death and dementia). Transition probabilities depend on two covariates, age and the presence/absence of an apolipoprotein E-epsilon4 allele, through a multinomial logistic model with shared random effects. Results are illustrated with an application to the Nun Study, a cohort of 678 participants 75+ years of age at baseline and followed longitudinally with up to ten cognitive assessments per nun.

  10. Effects of ignoring baseline on modeling transitions from intact cognition to dementia

    PubMed Central

    Yu, Lei; Tyas, Suzanne L.; Snowdon, David A.; Kryscio, Richard J.

    2009-01-01

    This paper evaluates the effect of ignoring baseline when modeling transitions from intact cognition to dementia with mild cognitive impairment (MCI) and global impairment (GI) as intervening cognitive states. Transitions among states are modeled by a discrete-time Markov chain having three transient (intact cognition, MCI, and GI) and two competing absorbing states (death and dementia). Transition probabilities depend on two covariates, age and the presence/absence of an apolipoprotein E-ε4 allele, through a multinomial logistic model with shared random effects. Results are illustrated with an application to the Nun Study, a cohort of 678 participants 75+ years of age at baseline and followed longitudinally with up to ten cognitive assessments per nun. PMID:20161282

  11. Modeling Verwey transition temperature of Fe3O4 nanocrystals

    NASA Astrophysics Data System (ADS)

    Jiang, Xiao bao; Xiao, Bei bei; Yang, Hong yu; Gu, Xiao yan; Sheng, Hong chao; Zhang, Xing hua

    2016-11-01

    The Verwey transition in nanoscale is an important physical property for Fe3O4 nanocrystals and has attracted extensive attention in recent years. In this work, an analytic thermodynamic model without any adjusting parameters is developed to estimate the size and shape effects on modulating the Verwey transition temperature of Fe3O4 nanocrystals. The results show that the Verwey transition temperature reduces with increasing shape parameter λ or decreasing size D. A good agreement between the prediction and the experimental data verified our physical insight that the Verwey transition of Fe3O4 can be directly related to the atomic thermal vibration. The results presented in this work will be of benefit to the understanding of the microscopic mechanism of the Verwey transition and the design of future generation switching and memory devices.

  12. Multiple Scenarios of Transition to Chaos in the Alternative Splicing Model

    NASA Astrophysics Data System (ADS)

    Kogai, Vladislav V.; Likhoshvai, Vitaly A.; Fadeev, Stanislav I.; Khlebodarova, Tamara M.

    We have investigated the scenarios of transition to chaos in the mathematical model of a genetic system constituted by a single transcription factor-encoding gene, the expression of which is self-regulated by a feedback loop that involves protein isoforms. Alternative splicing results in the synthesis of protein isoforms providing opposite regulatory outcomes — activation or repression. The model is represented by a differential equation with two delayed arguments. The possibility of transition to chaos dynamics via all classical scenarios: a cascade of period-doubling bifurcations, quasiperiodicity and type-I, type-II and type-III intermittencies, has been numerically demonstrated. The parametric features of each type of transition to chaos have been described.

  13. Hard is Normal: Military Families' Transitions Within the Process of Deployment.

    PubMed

    Yablonsky, Abigail M; Barbero, Edie Devers; Richardson, Jeanita W

    2016-02-01

    US military deployments have become more frequent and lengthier in duration since 2003. Over half of US military members are married, and many also have children. The authors sought to understand the process of deployment from the perspective of the military family. After a thorough search of the literature, 21 primary research reports of 19 studies with an aggregate sample of 874 were analyzed using qualitative metasynthesis. The deployment process was experienced in four temporal domains. The military family as a whole shared the pre-deployment transition: all family members felt uncertain about the future, needed to complete tasks to "get ready" for deployment, and experienced a sense of distancing in preparation for the upcoming separation. The AD member went through the deployment transition independently, needing to "stay engaged" with the military mission, building a surrogate family and simultaneously trying to maintain connection with the family at home. In parallel, the home front family was going through a transposement transition, moving forward as an altered family unit, taking on new roles and responsibilities, and trying to simultaneously connect with the deployed member and find support from other military families. In post-deployment, the family went through the "reintegration" transition together, managing expectations, and readjusting family roles, all needing understanding and appreciation for their sacrifices during the recent separation. Effective family communication was important for military family well-being after deployment but unexpectedly challenging for many. Clinical, research, and policy recommendations are discussed. © 2015 Wiley Periodicals, Inc. This article has been contributed to by a US Government employee and her work is in the public domain in the USA.

  14. Role transition from caregiver to case manager--Part II.

    PubMed

    Schmitt, Nancy

    2006-01-01

    This two-part article explores the process of role transition as it pertains to nurses moving from roles of caregivers to roles of case managers. Part 1 of the article presented a theoretical model that demonstrated the interplay of significant factors in the process of role transition and discussed how this model could be used to examine nurses' experience of this transition. Part 2 presents findings from a qualitative study involving interview and focus group data contributed by nurses who have made the transition from caregiver to case manager. Data point to specific tensions experienced by these nurses, which are associated with time-task orientation, interactions and relationships, business culture and objectives, and self-image and professional identity. Recommendations for preparing and supporting nurses through this role are also offered.

  15. The investigation of order–disorder transition process of ZSM-5 induced by spark plasma sintering

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wang, Liang; Wang, Lianjun, E-mail: wanglj@dhu.edu.cn; Jiang, Wan

    2014-04-01

    Based on the amorphization of zeolites, an order–disorder transition method was used to prepare silica glass via Spark Plasma Sintering (SPS). In order to get a better understanding about the mechanism of amorphization induced by SPS, the intermediate products in this process were prepared and characterized by different characterization techniques. X-ray diffraction and High-energy synchrotron X-ray scattering show a gradual transformation from ordered crystal to glass. Local structural changes in glass network including Si–O bond length, O–Si–O bond angle, size of rings, coordination were detected by Infrared spectroscopy and {sup 29}Si magic-angle spinning nuclear magnetic resonance (NMR) spectroscopy. Topologically ordered,more » amorphous material with a different intermediate-range structure can be obtained by precise control of intermediate process which can be expected to optimize and design material. - Graphical abstract: Low-density, ordered zeolites collapse to the rigid amorphous glass through spark plasma sintering. The intermediate-range structure formed in the process of order–disorder transition may give rise to specific property. - Highlights: • Order–disorder transition process of ZSM-5 induced by spark plasma sintering was investigated using several methods including XRD, High-energy synchrotron X-ray scattering, SAXS, IR, NMR, ect. • Order–disorder transition induced by SPS was compared with TIA and PIA. • Three stages has been divided during the whole process. • The collapse temperature range which may give rise to intermediate-range structure has been located.« less

  16. The effects of tonal and broadband acoustic excitation on the transition process within a laminar separation bubble

    NASA Astrophysics Data System (ADS)

    Yarusevych, Serhiy; Kurelek, John; Kotsonis, Marios

    2017-11-01

    The effects of controlled acoustic excitation on the transition process in a laminar separation bubble formed on the suction side of a NACA 0018 airfoil at a chord Reynolds number of 125,000 and an angle of attack of 4 degrees are studied experimentally. The investigation is carried out using time-resolved, planar, two-component Particle Image Velocimetry. Two types of excitation are considered: (i) tonal excitation at the frequency of the most unstable disturbances in the natural flow, and (ii) broadband excitation consisting bandpass filtered to the natural unstable frequency range, modelling two common types of airfoil self-noise production. For equal energy input levels, the results show that tonal and broadband types of excitation have equivalent effects on the mean flow field. Specifically, both cause the streamwise extent and height of the bubble to decrease. However, further analysis reveals notable differences in the underlying physics. For the tonal case, the transition process is dominated by the growth of disturbances at the excitation frequency that damps the growth of all other disturbances, leading to the formation of strongly coherent vortices in the aft portion of the separation bubble. On the other hand, broadband excitation promotes more moderate growth of all disturbances within the unstable frequency band, producing less coherent shear layer structures that experience earlier breakdown. Thus, the frequency content of acoustic excitation has a strong influence on the transition process in laminar separation bubbles. The authors gratefully acknowledge the Natural Sciences and Engineering Research Council of Canada (NSERC) for funding this work.

  17. Modeling demand for public transit services in rural areas

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Attaluri, P.; Seneviratne, P.N.; Javid, M.

    1997-05-01

    Accurate estimates of demand are critical for planning, designing, and operating public transit systems. Previous research has demonstrated that the expected demand in rural areas is a function of both demographic and transit system variables. Numerous models have been proposed to describe the relationship between the aforementioned variables. However, most of them are site specific and their validity over time and space is not reported or perhaps has not been tested. Moreover, input variables in some cases are extremely difficult to quantify. In this article, the estimation of demand using the generalized linear modeling technique is discussed. Two separate models,more » one for fixed-route and another for demand-responsive services, are presented. These models, calibrated with data from systems in nine different states, are used to demonstrate the appropriateness and validity of generalized linear models compared to the regression models. They explain over 70% of the variation in expected demand for fixed-route services and 60% of the variation in expected demand for demand-responsive services. It was found that the models are spatially transferable and that data for calibration are easily obtainable.« less

  18. Confirming Time-reversal Symmetry of a Directed Percolation Phase Transition in a Model of Neutral Evolutionary Dynamics

    NASA Astrophysics Data System (ADS)

    Ordway, Stephen; King, Dawn; Bahar, Sonya

    Reaction-diffusion processes, such as branching-coalescing random walks, can be used to describe the underlying dynamics of nonequilibrium phase transitions. In an agent-based, neutral model of evolutionary dynamics, we have previously shown that our system undergoes a continuous, nonequilibrium phase transition, from extinction to survival, as various system parameters were tuned. This model was shown to belong to the directed percolation (DP) universality class, by measuring the critical exponents corresponding to correlation length ξ⊥, correlation time ξ| |, and particle density β. The fourth critical exponent that defines the DP universality class is β', which measures the survival probability of growth from a single seed organism. Since DP universality is theorized to have time-reversal symmetry, it is assumed that β = β '. In order to confirm the existence of time-reversal symmetry in our model, we evaluate the system growth from a single asexually reproducing organism. Importantly, the critical exponent β' could be useful for comparison to experimental studies of phase transitions in biological systems, since observing growth of microbial populations is significantly easier than observing death. This research was supported by funding from the James S. McDonnell Foundation.

  19. Chemical analysis of extracting transition metal oxides from polymetallic ore by sulphate process

    NASA Astrophysics Data System (ADS)

    Enkh-Uyanga, Otgon-Uul; Munkhtsetseg, Baatar; Urangoo, Urtnasan; Tserendulam, Enkhtur; Agiimaa, Davaadorj

    2017-06-01

    In this research work we attempt to improve the purity of polymetallic ores in Mongolia whilst developing practical applications of its refinement processes and this paper presents the results of chemical research of extracting transition metal titanium oxides, ferrous oxide and rare earth oxides from polymetallic ore. Thereby, chemical and mineral analysis of polymetallic ore is carried out basis of responses to the support process at various degrees of water whereas transition metal sulphates solubility differ. As a result of sulphate and resulphurization process we have extracted anatase with 62.5 percent titanium dioxide and brookite mineral with 89.6 percent of titanium dioxide as well as mineral with 83.8 percent of ferrous oxide hematite and rare earth oxides with 57.6 percent of cerium oxide. These oxides are identified under various conditions in the thermal processing. The morphology structure and chemical content compound of the mineral has been verified as a result of the XRF, XRD, SEM-EDX analysis.

  20. Digital herders and phase transition in a voting model

    NASA Astrophysics Data System (ADS)

    Hisakado, M.; Mori, S.

    2011-07-01

    In this paper, we discuss a voting model with two candidates, C1 and C2. We set two types of voters—herders and independents. The voting of independent voters is based on their fundamental values; on the other hand, the voting of herders is based on the number of votes. Herders always select the majority of the previous r votes, which are visible to them. We call them digital herders. We can accurately calculate the distribution of votes for special cases. When r >= 3, we find that a phase transition occurs at the upper limit of t, where t is the discrete time (or number of votes). As the fraction of herders increases, the model features a phase transition beyond which a state where most voters make the correct choice coexists with one where most of them are wrong. On the other hand, when r < 3, there is no phase transition. In this case, the herders' performance is the same as that of the independent voters. Finally, we recognize the behavior of human beings by conducting simple experiments.

  1. Collaborative Assessment for Employment Planning: Transition Assessment and the Discovery Process

    ERIC Educational Resources Information Center

    Stevenson, Bradley S.; Fowler, Catherine H.

    2016-01-01

    As the Workforce Innovation and Opportunities Act (WIOA) is implemented across the nation, special education and vocational rehabilitation professionals will need to increase their level of collaboration. One area of potential collaboration is assessment--transition assessment for the field of special education and the discovery process for adult…

  2. Quasi-phases and pseudo-transitions in one-dimensional models with nearest neighbor interactions

    NASA Astrophysics Data System (ADS)

    de Souza, S. M.; Rojas, Onofre

    2018-01-01

    There are some particular one-dimensional models, such as the Ising-Heisenberg spin models with a variety of chain structures, which exhibit unexpected behaviors quite similar to the first and second order phase transition, which could be confused naively with an authentic phase transition. Through the analysis of the first derivative of free energy, such as entropy, magnetization, and internal energy, a "sudden" jump that closely resembles a first-order phase transition at finite temperature occurs. However, by analyzing the second derivative of free energy, such as specific heat and magnetic susceptibility at finite temperature, it behaves quite similarly to a second-order phase transition exhibiting an astonishingly sharp and fine peak. The correlation length also confirms the evidence of this pseudo-transition temperature, where a sharp peak occurs at the pseudo-critical temperature. We also present the necessary conditions for the emergence of these quasi-phases and pseudo-transitions.

  3. When University Faculty Retire: A Study of the Transition Process.

    ERIC Educational Resources Information Center

    Pappas, John G.; Goodman, Jane

    This study examined the retirement transitions of college faculty based on the Schlossberg (1984) model, which suggests that successful coping depends on an evaluation of the retiree's unique situation, the qualities of the individual, the support available, and the strategies employed. A total of 55 emeritus faculty from the College of Education…

  4. Self-management and Transition to Adult Health Care in Adolescents and Young Adults: A Team Process.

    PubMed

    Mahan, John D; Betz, Cecily L; Okumura, Megumi J; Ferris, Maria E

    2017-07-01

    As health care continues to evolve, the need for more effective health care transition (HCT) for all youth, but particularly children with chronic conditions and special health care needs, becomes even more important. With more than 90% of adolescents with chronic medical conditions now surviving into adulthood, suboptimal transition can lead to poorer quality of life and less successful adulthood.Through a series of clinical vignettes, the challenges of HCT are presented herein and accompanied by comments that underscore how these adolescents can best be helped to transition to successful adulthood. Several methods are presented to assess the readiness of adolescents and young adults (AYA) for transition. The process of transition can be divided into 3 stages: 1) setting the stage: initiation of HCT services and transition readiness assessment, 2) moving forward: ongoing provision of HCT services, and 3) reaching the goal: transfer of care and transition to adulthood.Several valuable suggestions for incorporating the HCT process into the health care system and improving HCT programs through a quality improvement (QI) approach are outlined. Future challenges in HCT include developing more precise assessments of transition status or transition readiness, better understanding the status and specific needs of AYA with chronic health care needs, continued program evaluation and QI efforts, and more reliance on patients and families to teach us about the challenges and methods in HCT that most effectively work for them. © American Academy of Pediatrics, 2017. All rights reserved.

  5. Digital Sketch Modelling: Integrating Digital Sketching as a Transition between Sketching and CAD in Industrial Design Education

    ERIC Educational Resources Information Center

    Ranscombe, Charlie; Bissett-Johnson, Katherine

    2017-01-01

    Literature on the use of design tools in educational settings notes an uneasy relationship between student use of traditional hand sketching and digital modelling tools (CAD) during the industrial design process. This is often manifested in the transition from sketching to CAD and exacerbated by a preference of current students to use CAD. In this…

  6. [The transition process from the intensive care unit to the ward: a review of the literature].

    PubMed

    Vázquez Calatayud, M; Portillo, M C

    2013-01-01

    The optimum transition process from the ICU to the ward is key to avoiding the appearance of anxiety in the patient and family, increase of re-admissions in the ICU with the consequent increase in costs and jeopardization to the patient's safety. 1) To identify, study and give a critical presentation of the existing evidence on how patients, families and nurses experience the transition from ICU to the ward; 2) to analyze the possible interventions available for the development of an optimum transition process. A review was made of the evidence available in the main databases. In addition, several journals specialized in Intensive Care were reviewed. Studies with a qualitative, quantitative or mixed approach and reviews on the subject with a systematic methodology or narrative reviews were included. A total of 23 papers were selected for review, 10 of which were qualitative studies, 11 quantitative and two had combined methodology. «Transfer anxiety» was identified after the analysis of these articles as one of the recurring aspects. Discrepancies regarding who should take responsibility for the preparation of the transition process and when it should be performed were also found. In the literature reviewed, several interventions have been proposed to facilitate an optimal transition process such as developing information brochures, creating a profile of practicing nursing liaison between the ICU and the ward and ICU discharge report. This review emphasizes the importance of taking into account the perspectives of patients, families and nurses to perform optimal planning of the transition of the patient from the ICU to the ward to ensure their safety. Copyright © 2012 Elsevier España, S.L. y SEEIUC. All rights reserved.

  7. Transition to turbulence under low-pressure turbine conditions.

    PubMed

    Simon, T W; Kaszeta, R W

    2001-05-01

    In this paper, the topic of laminar to turbulent flow transition, as applied to the design of gas turbines, is discussed. Transition comes about when a flow becomes sufficiently unstable that the orderly vorticity structure of the laminar layer becomes randomly oriented. Vorticity with a streamwise component leads to rapid growth of eddies of a wide range of sizes and eventually to turbulent flow. Under "natural" transition, infinitesimal disturbances of selected frequencies grow. "Bypass transition" is a term coined to describe a similar process, but one driven by strong external disturbances. Transition proceeds so rapidly that the processes associated with "natural" transition seem to be "bypassed." Because the flow environment in the turbine is disturbed by wakes from upstream airfoils, eddies from combustor flows, jets from film cooling, separation zones on upstream airfoils and steps in the duct walls, transition is of the bypass mode. In this paper, we discuss work that has been done to characterize and model bypass transition, as applied to the turbine environment.

  8. Elastic Model Transitions: A Hybrid Approach Utilizing Quadratic Inequality Constrained Least Squares (LSQI) and Direct Shape Mapping (DSM)

    NASA Technical Reports Server (NTRS)

    Hannan, Mike R.; Jurenko, Robert J.; Bush, Jason; Ottander, John

    2014-01-01

    A method for transitioning linear time invariant (LTI) models in time varying simulation is proposed that utilizes a hybrid approach for determining physical displacements by augmenting the original quadratically constrained least squares (LSQI) algorithm with Direct Shape Mapping (DSM) and modifying the energy constraints. The approach presented is applicable to simulation of the elastic behavior of launch vehicles and other structures that utilize discrete LTI finite element model (FEM) derived mode sets (eigenvalues and eigenvectors) that are propagated throughout time. The time invariant nature of the elastic data presents a problem of how to properly transition elastic states from the prior to the new model while preserving motion across the transition and ensuring there is no truncation or excitation of the system. A previous approach utilizes a LSQI algorithm with an energy constraint to effect smooth transitions between eigenvector sets with no requirement that the models be of similar dimension or have any correlation. This approach assumes energy is conserved across the transition, which results in significant non-physical transients due to changing quasi-steady state energy between mode sets, a phenomenon seen when utilizing a truncated mode set. The computational burden of simulating a full mode set is significant so a subset of modes is often selected to reduce run time. As a result of this truncation, energy between mode sets may not be constant and solutions across transitions could produce non-physical transients. In an effort to abate these transients an improved methodology was developed based on the aforementioned approach, but this new approach can handle significant changes in energy across mode set transitions. It is proposed that physical velocities due to elastic behavior be solved for using the LSQI algorithm, but solve for displacements using a two-step process that independently addresses the quasi-steady-state and non

  9. An investigation into the numerical prediction of boundary layer transition using the K.Y. Chien turbulence model

    NASA Technical Reports Server (NTRS)

    Stephens, Craig A.; Crawford, Michael E.

    1990-01-01

    Assessments were made of the simulation capabilities of transition models developed at the University of Minnesota, as applied to the Launder-Sharma and Lam-Bremhorst two-equation turbulence models, and at The University of Texas at Austin, as applied to the K. Y. Chien two-equation turbulence model. A major shortcoming in the use of the basic K. Y. Chien turbulence model for low-Reynolds number flows was identified. The problem with the Chien model involved premature start of natural transition and a damped response as the simulation moved to fully turbulent flow at the end of transition. This is in contrast to the other two-equation turbulence models at comparable freestream turbulence conditions. The damping of the transition response of the Chien turbulence model leads to an inaccurate estimate of the start and end of transition for freestream turbulence levels greater than 1.0 percent and to difficulty in calculating proper model constants for the transition model.

  10. Learning in occupational transitions: a study of the process following job loss.

    PubMed

    Hallqvist, Anders; Hydén, Lars-Christer

    2012-01-01

    This article examines how workers supported by outplacement services engage with an occupational transition through problem solving and learning. The participants were 23 mid-life redundant white collar workers with at least eight years in their sector, organization or occupation. The selected interviewees either participated in training to broaden their professional competence or did not make any such 'expansive' efforts. The study was based on narrative interviews, which enabled a detailed cross case examination of individuals' actions and choices and how the process unfolds over time. The results showed that people treat their job loss as a practical problem to be solved using various strategies. This problem-solving process is structured, with people passing similar crossroads defining particular challenges and opportunities giving people limited sets of choices. The results point to the significance of creativity and learning in occupational transitions.

  11. A latent transition model of the effects of a teen dating violence prevention initiative.

    PubMed

    Williams, Jason; Miller, Shari; Cutbush, Stacey; Gibbs, Deborah; Clinton-Sherrod, Monique; Jones, Sarah

    2015-02-01

    Patterns of physical and psychological teen dating violence (TDV) perpetration, victimization, and related behaviors were examined with data from the evaluation of the Start Strong: Building Healthy Teen Relationships initiative, a dating violence primary prevention program targeting middle school students. Latent class and latent transition models were used to estimate distinct patterns of TDV and related behaviors of bullying and sexual harassment in seventh grade students at baseline and to estimate transition probabilities from one pattern of behavior to another at the 1-year follow-up. Intervention effects were estimated by conditioning transitions on exposure to Start Strong. Latent class analyses suggested four classes best captured patterns of these interrelated behaviors. Classes were characterized by elevated perpetration and victimization on most behaviors (the multiproblem class), bullying perpetration/victimization and sexual harassment victimization (the bully-harassment victimization class), bullying perpetration/victimization and psychological TDV victimization (bully-psychological victimization), and experience of bully victimization (bully victimization). Latent transition models indicated greater stability of class membership in the comparison group. Intervention students were less likely to transition to the most problematic pattern and more likely to transition to the least problem class. Although Start Strong has not been found to significantly change TDV, alternative evaluation models may find important differences. Latent transition analysis models suggest positive intervention impact, especially for the transitions at the most and the least positive end of the spectrum. Copyright © 2015. Published by Elsevier Inc.

  12. Transition from in-hospital ventilation to home ventilation: process description and quality indicators

    PubMed Central

    Kastrup, Marc; Tittmann, Benjamin; Sawatzki, Tanja; Gersch, Martin; Vogt, Charlotte; Rosenthal, Max; Rosseau, Simone; Spies, Claudia

    2017-01-01

    The current demographic development of our society results in an increasing number of elderly patients with chronic diseases being treated in the intensive care unit. A possible long-term consequence of such a treatment is that patients remain dependent on certain invasive organ support systems, such as long-term ventilator dependency. The main goal of this project is to define the transition process between in-hospital and out of hospital (ambulatory) ventilator support. A further goal is to identify evidence-based quality indicators to help define and describe this process. This project describes an ideal sequence of processes (process chain), based on the current evidence from the literature. Besides the process chain, key data and quality indicators were described in detail. Due to the limited project timeline, these indicators were not extensively tested in the clinical environment. The results of this project may serve as a solid basis for proof of feasibility and proof of concept investigations, optimize the transition process of ventilator-dependent patients from a clinical to an ambulatory setting, as well as reduce the rate of emergency re-admissions. PMID:29308061

  13. Presidential Transition Teams: Fostering a Collaborative Transition Process

    ERIC Educational Resources Information Center

    Artman, Richard B.; Franz, Mark

    2009-01-01

    Whether hiring a sitting president or one beginning a first presidency, the board of trustees should be keenly interested in ensuring that the new president's first months in office flow as smoothly as possible. Increasing attention has been paid in recent years to the idea of using a transition team to assist the new president. Using a transition…

  14. Glass Transition Temperature- and Specific Volume- Composition Models for Tellurite Glasses

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Riley, Brian J.; Vienna, John D.

    This report provides models for predicting composition-properties for tellurite glasses, namely specific gravity and glass transition temperature. Included are the partial specific coefficients for each model, the component validity ranges, and model fit parameters.

  15. Configurable product design considering the transition of multi-hierarchical models

    NASA Astrophysics Data System (ADS)

    Ren, Bin; Qiu, Lemiao; Zhang, Shuyou; Tan, Jianrong; Cheng, Jin

    2013-03-01

    The current research of configurable product design mainly focuses on how to convert a predefined set of components into a valid set of product structures. With the scale and complexity of configurable products increasing, the interdependencies between customer demands and product structures grow up as well. The result is that existing product structures fails to satisfy the individual customer requirements and hence product variants are needed. This paper is aimed to build a bridge between customer demands and product structures in order to make demand-driven fast response design feasible. First of all, multi-hierarchical models of configurable product design are established with customer demand model, technical requirement model and product structure model. Then, the transition of multi-hierarchical models among customer demand model, technical requirement model and product structure model is solved with fuzzy analytic hierarchy process (FAHP) and the algorithm of multi-level matching. Finally, optimal structure according to the customer demands is obtained with the calculation of Euclidean distance and similarity of some cases. In practice, the configuration design of a clamping unit of injection molding machine successfully performs an optimal search strategy for the product variants with reasonable satisfaction to individual customer demands. The proposed method can automatically generate a configuration design with better alternatives for each product structures, and shorten the time of finding the configuration of a product.

  16. Phase transitions, interparticle correlations, and elementary processes in dense plasmas

    NASA Astrophysics Data System (ADS)

    Ichimaru, Setsuo

    2017-12-01

    Astrophysical dense plasmas are those we find in the interiors, surfaces, and outer envelopes of stellar objects such as neutron stars, white dwarfs, the Sun, and giant planets. Condensed plasmas in the laboratory settings include those in ultrahigh-pressure metal-physics experiments undertaken for realization of metallic hydrogen. We review basic physics issues studied in the past 60 some years on the phase transitions, the interparticle correlations, and the elementary processes in dense plasmas, through survey on scattering of electromagnetic waves, equations of state, phase diagrams, transport processes, stellar and planetary magnetisms, and thermo- and pycnonuclear reactions.

  17. Applicability of the SMART Model of Transition Readiness for Sickle-Cell Disease

    PubMed Central

    Valenzuela, Jessica M.; Crosby, Lori E.; Diaz Pow Sang, Claudia

    2016-01-01

    Objectives This study aimed to examine the applicability of the Social-ecological Model of Adolescent and Young Adult Readiness to Transition (SMART) model for adolescents and young adults (AYA) with sickle-cell disease (SCD). Methods 14 AYA with SCD (14–24 years old) and 10 clinical experts (6–20 years of experience) completed semi-structured interviews. AYA completed brief questionnaires. Interviews were coded for themes, which were reviewed to determine their fit within the SMART model. Results Overall, most themes were consistent with the model (e.g., sociodemographics/culture, neurocognition/IQ, etc.). Factors related to race/culture, pain management, health-care navigation skills, societal stigma, and lack of awareness about SCD were salient for AYA with SCD. Conclusions Findings suggest the SMART model may be appropriate in SCD with the consideration of disease-related stigma. This study is a step toward developing a disease-specific model of transition readiness for SCD. Future directions include the development of a measure of transition readiness for this population. PMID:26717957

  18. Dynamic coordinated control during mode transition process for a compound power-split hybrid electric vehicle

    NASA Astrophysics Data System (ADS)

    Su, Yanzhao; Hu, Minghui; Su, Ling; Qin, Datong; Zhang, Tong; Fu, Chunyun

    2018-07-01

    The fuel economy of the hybrid electric vehicles (HEVs) can be effectively improved by the mode transition (MT). However, for a power-split powertrain whose power-split transmission is directly connected to the engine, the engine ripple torque (ERT), inconsistent dynamic characteristics (IDC) of engine and motors, model estimation inaccuracies (MEI), system parameter uncertainties (SPU) can cause jerk and vibration of transmission system during the MT process, which will reduce the driving comfort and the life of the drive parts. To tackle these problems, a dynamic coordinated control strategy (DCCS), including a staged engine torque feedforward and feedback estimation (ETFBC) and an active damping feedback compensation (ADBC) based on drive shaft torque estimation (DSTE), is proposed. And the effectiveness of this strategy is verified using a plant model. Firstly, the powertrain plant model is established, and the MT process and problems are analyzed. Secondly, considering the characteristics of the engine torque estimation (ETE) model before and after engine ignition, a motor torque compensation control based on the staged ERT estimation is developed. Then, considering the MEI, SPU and the load change, an ADBC based on a real-time nonlinear reduced-order robust observer of the DSTE is designed. Finally, the simulation results show that the proposed DCCS can effectively improve the driving comfort.

  19. Remote sensing, geographical information systems, and spatial modeling for analyzing public transit services

    NASA Astrophysics Data System (ADS)

    Wu, Changshan

    Public transit service is a promising transportation mode because of its potential to address urban sustainability. Current ridership of public transit, however, is very low in most urban regions, particularly those in the United States. This woeful transit ridership can be attributed to many factors, among which poor service quality is key. Given this, there is a need for transit planning and analysis to improve service quality. Traditionally, spatially aggregate data are utilized in transit analysis and planning. Examples include data associated with the census, zip codes, states, etc. Few studies, however, address the influences of spatially aggregate data on transit planning results. In this research, previous studies in transit planning that use spatially aggregate data are reviewed. Next, problems associated with the utilization of aggregate data, the so-called modifiable areal unit problem (MAUP), are detailed and the need for fine resolution data to support public transit planning is argued. Fine resolution data is generated using intelligent interpolation techniques with the help of remote sensing imagery. In particular, impervious surface fraction, an important socio-economic indicator, is estimated through a fully constrained linear spectral mixture model using Landsat Enhanced Thematic Mapper Plus (ETM+) data within the metropolitan area of Columbus, Ohio in the United States. Four endmembers, low albedo, high albedo, vegetation, and soil are selected to model heterogeneous urban land cover. Impervious surface fraction is estimated by analyzing low and high albedo endmembers. With the derived impervious surface fraction, three spatial interpolation methods, spatial regression, dasymetric mapping, and cokriging, are developed to interpolate detailed population density. Results suggest that cokriging applied to impervious surface is a better alternative for estimating fine resolution population density. With the derived fine resolution data, a multiple

  20. Modeling the hepatitis A epidemiological transition in Brazil and Mexico

    PubMed Central

    Van Effelterre, Thierry; Guignard, Adrienne; Marano, Cinzia; Rojas, Rosalba; Jacobsen, Kathryn H.

    2017-01-01

    ABSTRACT Background: Many low- to middle-income countries have completed or are in the process of transitioning from high or intermediate to low endemicity for hepatitis A virus (HAV). Because the risk of severe hepatitis A disease increases with age at infection, decreased incidence that leaves older children and adults susceptible to HAV infection may actually increase the population-level burden of disease from HAV. Mathematical models can be helpful for projecting future epidemiological profiles for HAV. Methods: An age-specific deterministic, dynamic compartmental transmission model with stratification by setting (rural versus urban) was calibrated with country-specific data on demography, urbanization, and seroprevalence of anti-HAV antibodies. HAV transmission was modeled as a function of setting-specific access to safe water. The model was then used to project various HAV-related epidemiological outcomes in Brazil and in Mexico from 1950 to 2050. Results: The projected epidemiological outcomes were qualitatively similar in the 2 countries. The age at the midpoint of population immunity (AMPI) increased considerably and the mean age of symptomatic HAV cases shifted from childhood to early adulthood. The projected overall incidence rate of HAV infections decreased by about two thirds as safe water access improved. However, the incidence rate of symptomatic HAV infections remained roughly the same over the projection period. The incidence rates of HAV infections (all and symptomatic alone) were projected to become similar in rural and urban settings in the next decades. Conclusion: This model featuring population age structure, urbanization and access to safe water as key contributors to the epidemiological transition for HAV was previously validated with data from Thailand and fits equally well with data from Latin American countries. Assuming no introduction of a vaccination program over the projection period, both Brazil and Mexico were projected to

  1. Neonatal nurse practitioner role transition: the process of reattaining expert status.

    PubMed

    Cusson, Regina M; Strange, Sally Nelson

    2008-01-01

    Neonatal nurse practitioners (NNPs) have managed care for high-risk hospitalized infants in the United States for over 30 years. The journey from being expert nurse to being novice NNP and then finally to being expert NNP is fraught with many challenges. This study used a qualitative descriptive design to describe advanced practice role transition among 70 NNPs. The data consisted of participants' written responses to open-ended questions. Four themes emerged that depicted a linear progression of the transition process from school preparation to beginning feelings in the new role and then development into a more confident practice. Theme 1: First impressions emphasized the ambivalence novice NNPs experienced regarding their preparedness for the role during a stressful and exciting adjustment period. Theme 2: The transition demonstrated the overwhelmingly similar feelings of anxiety, insecurity, exhaustion, and lack of confidence that plagued decision making. Theme 3: Making it as a real NNP indicated that the 1-year mark was a consistent, significant timeframe for feeling like a real NNP. Theme 4: The helpers and hinderers revealed the vulnerability of the novice NNPs to harsh criticism as well as the importance of support, especially from nurse colleagues. NNPs are a valuable resource; thus, enhancing transition is a worthy goal.

  2. Perspectives of Youth in Foster Care on Essential Ingredients for Promoting Self-determination and Successful Transition to Adult Life: My Life Model.

    PubMed

    Powers, Laurie E; Fullerton, Ann; Schmidt, Jessica; Geenen, Sarah; Oberweiser-Kennedy, Molly; Dohn, JoAnn; Nelson, May; Iavanditti, Rosemary; Blakeslee, Jennifer

    2018-02-01

    Research clearly documents the serious challenges and poor outcomes experienced by many young people exiting foster care, as well as compounded disparities for the high percentage of youth in care who are identified with disabilities and/or mental health challenges. However, very little research has been conducted to specify or validate effective models for improving the transition trajectories of youth exiting care. Evidence suggests the My Life self-determination enhancement model offers a promising approach for supporting youths' self-determined and positive transition to adulthood. The model includes youth-directed, experientially oriented coaching in the application of self-determination skills to achieve youth-identified transition goals, coupled with peer mentoring workshops that provide opportunities for learning, networking and fun. This in depth qualitative study of 10 youth who completed the My Life intervention focused on investigating coaching and mentoring elements and processes that youth participants identify as most important to their success, with the intention of informing the further development of youth-directed approaches to supporting young people who are transitioning to adulthood. Themes emerged around the centrality of youth self-direction, important processes in the coaching relationship, the essential value of experiential activities and self-determination skill development, and peer mentoring experiences that youth identified as fostering their success. Implications are discussed for research and practice in supporting youth exiting foster care.

  3. Glass Transition Temperature of Saccharide Aqueous Solutions Estimated with the Free Volume/Percolation Model.

    PubMed

    Constantin, Julian Gelman; Schneider, Matthias; Corti, Horacio R

    2016-06-09

    The glass transition temperature of trehalose, sucrose, glucose, and fructose aqueous solutions has been predicted as a function of the water content by using the free volume/percolation model (FVPM). This model only requires the molar volume of water in the liquid and supercooled regimes, the molar volumes of the hypothetical pure liquid sugars at temperatures below their pure glass transition temperatures, and the molar volumes of the mixtures at the glass transition temperature. The model is simplified by assuming that the excess thermal expansion coefficient is negligible for saccharide-water mixtures, and this ideal FVPM becomes identical to the Gordon-Taylor model. It was found that the behavior of the water molar volume in trehalose-water mixtures at low temperatures can be obtained by assuming that the FVPM holds for this mixture. The temperature dependence of the water molar volume in the supercooled region of interest seems to be compatible with the recent hypothesis on the existence of two structure of liquid water, being the high density liquid water the state of water in the sugar solutions. The idealized FVPM describes the measured glass transition temperature of sucrose, glucose, and fructose aqueous solutions, with much better accuracy than both the Gordon-Taylor model based on an empirical kGT constant dependent on the saccharide glass transition temperature and the Couchman-Karasz model using experimental heat capacity changes of the components at the glass transition temperature. Thus, FVPM seems to be an excellent tool to predict the glass transition temperature of other aqueous saccharides and polyols solutions by resorting to volumetric information easily available.

  4. Application of the algebraic RNG model for transition simulation. [renormalization group theory

    NASA Technical Reports Server (NTRS)

    Lund, Thomas S.

    1990-01-01

    The algebraic form of the RNG model of Yakhot and Orszag (1986) is investigated as a transition model for the Reynolds averaged boundary layer equations. It is found that the cubic equation for the eddy viscosity contains both a jump discontinuity and one spurious root. A yet unpublished transformation to a quartic equation is shown to remove the numerical difficulties associated with the discontinuity, but only at the expense of merging both the physical and spurious root of the cubic. Jumps between the branches of the resulting multiple-valued solution are found to lead to oscillations in flat plate transition calculations. Aside from the oscillations, the transition behavior is qualitatively correct.

  5. Testing of transition-region models: Test cases and data

    NASA Technical Reports Server (NTRS)

    Singer, Bart A.; Dinavahi, Surya; Iyer, Venkit

    1991-01-01

    Mean flow quantities in the laminar turbulent transition region and in the fully turbulent region are predicted with different models incorporated into a 3-D boundary layer code. The predicted quantities are compared with experimental data for a large number of different flows and the suitability of the models for each flow is evaluated.

  6. A theoretical model of grain boundary self-diffusion in metals with phase transitions (case study into titanium and zirconium)

    NASA Astrophysics Data System (ADS)

    Semenycheva, Alexandra V.; Chuvil'deev, Vladimir N.; Nokhrin, Aleksey V.

    2018-05-01

    The paper offers a model describing the process of grain boundary self-diffusion in metals with phase transitions in the solid state. The model is based on ideas and approaches found in the theory of non-equilibrium grain boundaries. The range of application of basic relations contained in this theory is shown to expand, as they can be used to calculate the parameters of grain boundary self-diffusion in high-temperature and low-temperature phases of metals with a phase transition. The model constructed is used to calculate grain boundary self-diffusion activation energy in titanium and zirconium and an explanation is provided as to their abnormally low values in the low-temperature phase. The values of grain boundary self-diffusion activation energy are in good agreement with the experiment.

  7. Center for modeling of turbulence and transition: Research briefs, 1993

    NASA Technical Reports Server (NTRS)

    Liou, William W. (Editor)

    1994-01-01

    This research brief contains the progress reports of the research staff of the Center for Modeling of Turbulence and Transition (CMOTT) from June 1992 to July 1993. It is also an annual report to the Institute for Computational Mechanics in Propulsion located at Ohio Aerospace Institute and NASA Lewis Research Center. The main objectives of the research activities at CMOTT are to develop, validate, and implement turbulence and transition models for flows of interest in propulsion systems. Currently, our research covers eddy viscosity one- and two-equation models, Reynolds-stress algebraic equation models, Reynolds-stress transport equation models, nonequilibrium multiple-scale models, bypass transition models, joint scalar probability density function models, and Renormalization Group Theory and Direct Interaction Approximation methods. Some numerical simulations (LES and DNS) have also been carried out to support the development of turbulence modeling. Last year was CMOTT's third year in operation. During this period, in addition to the above mentioned research, CMOTT has also hosted the following programs: an eighteen-hour short course on 'Turbulence--Fundamentals and Computational Modeling (Part I)' given by CMOTT at the NASA Lewis Research Center; a productive summer visitor research program that has generated many encouraging results; collaborative programs with industry customers to help improve their turbulent flow calculations for propulsion system designs; a biweekly CMOTT seminar series with speakers from within and without the NASA Lewis Research Center including foreign speakers. In addition, CMOTT members have been actively involved in the national and international turbulence research activities. The current CMOTT roster and organization are listed in Appendix A. Listed in Appendix B are the abstracts of the biweekly CMOTT seminar. Appendix C lists the papers contributed by CMOTT members.

  8. Low temperature electroweak phase transition in the Standard Model with hidden scale invariance

    NASA Astrophysics Data System (ADS)

    Arunasalam, Suntharan; Kobakhidze, Archil; Lagger, Cyril; Liang, Shelley; Zhou, Albert

    2018-01-01

    We discuss a cosmological phase transition within the Standard Model which incorporates spontaneously broken scale invariance as a low-energy theory. In addition to the Standard Model fields, the minimal model involves a light dilaton, which acquires a large vacuum expectation value (VEV) through the mechanism of dimensional transmutation. Under the assumption of the cancellation of the vacuum energy, the dilaton develops a very small mass at 2-loop order. As a result, a flat direction is present in the classical dilaton-Higgs potential at zero temperature while the quantum potential admits two (almost) degenerate local minima with unbroken and broken electroweak symmetry. We found that the cosmological electroweak phase transition in this model can only be triggered by a QCD chiral symmetry breaking phase transition at low temperatures, T ≲ 132 MeV. Furthermore, unlike the standard case, the universe settles into the chiral symmetry breaking vacuum via a first-order phase transition which gives rise to a stochastic gravitational background with a peak frequency ∼10-8 Hz as well as triggers the production of approximately solar mass primordial black holes. The observation of these signatures of cosmological phase transitions together with the detection of a light dilaton would provide a strong hint of the fundamental role of scale invariance in particle physics.

  9. Two Distinct Synchronization Processes in the Transition to Sleep: A High-Density Electroencephalographic Study

    PubMed Central

    Siclari, Francesca; Bernardi, Giulio; Riedner, Brady A.; LaRocque, Joshua J.; Benca, Ruth M.; Tononi, Giulio

    2014-01-01

    Objectives: To assess how the characteristics of slow waves and spindles change in the falling-asleep process. Design: Participants undergoing overnight high-density electroencephalographic recordings were awakened at 15- to 30-min intervals. One hundred forty-one falling-asleep periods were analyzed at the scalp and source level. Setting: Sleep laboratory. Participants: Six healthy participants. Interventions: Serial awakenings. Results: The number and amplitude of slow waves followed two dissociated, intersecting courses during the transition to sleep: slow wave number increased slowly at the beginning and rapidly at the end of the falling-asleep period, whereas amplitude at first increased rapidly and then decreased linearly. Most slow waves occurring early in the transition to sleep had a large amplitude, a steep slope, involved broad regions of the cortex, predominated over frontomedial regions, and preferentially originated from the sensorimotor and the posteromedial parietal cortex. Most slow waves occurring later had a smaller amplitude and slope, involved more circumscribed parts of the cortex, and had more evenly distributed origins. Spindles were initially sparse, fast, and involved few cortical regions, then became more numerous and slower, and involved more areas. Conclusions: Our results provide evidence for two types of slow waves, which follow dissociated temporal courses in the transition to sleep and have distinct cortical origins and distributions. We hypothesize that these two types of slow waves result from two distinct synchronization processes: (1) a “bottom-up,” subcorticocortical, arousal system-dependent process that predominates in the early phase and leads to type I slow waves, and (2) a “horizontal,” corticocortical synchronization process that predominates in the late phase and leads to type II slow waves. The dissociation between these two synchronization processes in time and space suggests that they may be differentially

  10. [Establishment of a canine slow transit constipation model and evalution of defecation, gastrointestinal transit and pathological sections].

    PubMed

    Zhu, D; Chen, S; Yao, S K; Li, Y M; Chen, S X

    2018-06-12

    Objective: To establish a canine model of slow transit constipation (STC), and to test the changes in defecation, gastrointestinal transit time and pathology sections. Methods: Baseline information was measured in 8 beagle dogs, and these dogs were randomly divided into the control group and the model group. The dogs in model group were given a diet of canned meat, as well as a combination of compound diphenoxylate and alosetron hydrochloride for 5 weeks. Dogs in control group were given normal diet with no special intervention. Stool frequency and consistency were observed and recorded daily, and the gastrointestinal transit time (GITT) were measured every week. All animals underwent the midline laparotomy and the colonic tissues were taken from the rectosigmoid colon, then investigated by light microscopy, electron microscopy, and immunohistochemistry to evaluate changes of protein gene product 9.5(PGP9.5), synaptophysin and c-kit between two groups. Results: 8 beagle dogs underwent all experiment items successfully.Both of the stool frequency and scores of stool consistency decreased in model group( F =6.568, P =0.043; F =25.954, P =0.002). GITT delayed in model group( F =42.573, P =0.001). After 5 weeks of intervention, in the model group, the myenteric neurons and interstitial cells of Cajal showed damage such as swelling of mitochondria under electron microscopy, and both of the PGP9.5 and synaptophysin integrated option density of rectosigmoid colon were decreased ( t =3.471, P =0.013; t =2.506, P =0.046)under immunohistochemistry. The c-kit integrated option density showed no statistically significant differences between two groups( t =1.709, P =0.138). Conclusions: The canine model of STC which was consistent with clinical symptoms and pathological changes was successfully established, and it can be used to observe and evaluate the therapeutic effect of electrical stimulation, surgery and so on.

  11. From Further to Higher Education: Transition as an On-Going Process

    ERIC Educational Resources Information Center

    Tett, Lyn; Cree, Viviene E; Christie, Hazel

    2017-01-01

    This paper argues that transition is not a one-off event that occurs when students first enter universities but is an on-going process that is repeated over time. We draw on qualitative data from a longitudinal project on "non-traditional" students who entered a research-intensive university in Scotland direct from further education…

  12. Comprehensive Validation of an Intermittency Transport Model for Transitional Low-Pressure Turbine Flows

    NASA Technical Reports Server (NTRS)

    Suzen, Y. B.; Huang, P. G.

    2005-01-01

    A transport equation for the intermittency factor is employed to predict transitional flows under the effects of pressure gradients, freestream turbulence intensities, Reynolds number variations, flow separation and reattachment. and unsteady wake-blade interactions representing diverse operating conditions encountered in low-pressure turbines. The intermittent behaviour of the transitional flows is taken into account and incorporated into computations by modifying the eddy viscosity, Mu(sub t), with the intermittency factor, gamma. Turbulent quantities are predicted by using Menter's two-equation turbulence model (SST). The onset location of transition is obtained from correlations based on boundary-layer momentum thickness, acceleration parameter, and turbulence intensity. The intermittency factor is obtained from a transport model which can produce both the experimentally observed streamwise variation of intermittency and a realistic profile in the cross stream direction. The intermittency transport model is tested and validated against several well documented low pressure turbine experiments ranging from flat plate cases to unsteady wake-blade interaction experiments. Overall, good agreement between the experimental data and computational results is obtained illustrating the predicting capabilities of the model and the current intermittency transport modelling approach for transitional flow simulations.

  13. The behavior of commensurate-incommensurate transitions using the phase field crystal model

    NASA Astrophysics Data System (ADS)

    Zhang, Tinghui; Lu, Yanli; Chen, Zheng

    2018-02-01

    We study the behavior of the commensurate-incommensurate (CI) transitions by using a phase field crystal model. The model is capable of modeling both elastic and plastic deformation and can simulate the evolution of the microstructure of the material at the atomic scale and the diffusive time scale, such as for adsorbed monolayer. Specifically, we study the behavior of the CI transitions as a function of lattice mismatch and the amplitude of substrate pinning potential. The behavior of CI phase transitions is revealed with the increase of the amplitude of pinning potential in some certain lattice mismatches. We find that for the negative lattice mismatch absorbed monolayer undergoes division, reorganization and displacement as increasing the amplitude of substrate pinning potential. In addition, for the positive mismatch absorbed monolayer undergoes a progress of phase transformation after a complete grain is split. Our results accord with simulations for atomic models of absorbed monolayer on a substrate surface.

  14. The Nonlinear Jaynes-Cummings Model for the Multiphoton Transition

    NASA Astrophysics Data System (ADS)

    Liu, Xiao-Jing; Lu, Jing-Bin; Zhang, Si-Qi; Liu, Ji-Ping; Li, Hong; Liang, Yu; Ma, Ji; Weng, Yi-Jiao; Zhang, Qi-Rui; Liu, Han; Zhang, Xiao-Ru; Wu, Xiang-Yao

    2018-01-01

    With the nonlinear Jaynes-Cummings model, we have studied the atom and light field quantum entanglement of multiphoton transition in nonlinear medium, and researched the effect of the transition photon number N and the nonlinear coefficient χ on the quantum entanglement degrees. We have given the quantum entanglement degrees curves with time evolution, we find when the transition photon number N increases, the entanglement degrees oscillation get faster. When the nonlinear coefficient α > 0, the entanglement degrees oscillation get quickly, the nonlinear term is disadvantage of the atom and light field entanglement, and when the nonlinear coefficient α < 0, the entanglement degrees oscillation get slow, the nonlinear term is advantage of the atom and light field entanglement. These results will have been used in the quantum communication and quantum information.

  15. Thermodynamic behavior of a phase transition in a model for sympatric speciation

    NASA Astrophysics Data System (ADS)

    Luz-Burgoa, K.; Moss de Oliveira, S.; Schwämmle, Veit; Sá Martins, J. S.

    2006-08-01

    We investigate the macroscopic effects of the ingredients that drive the origin of species through sympatric speciation. In our model, sympatric speciation is obtained as we tune up the strength of competition between individuals with different phenotypes. As a function of this control parameter, we can characterize, through the behavior of a macroscopic order parameter, a phase transition from a nonspeciation to a speciation state of the system. The behavior of the first derivative of the order parameter with respect to the control parameter is consistent with a phase transition and exhibits a sharp peak at the transition point. For different resources distribution, the transition point is shifted, an effect similar to pressure in a PVT system. The inverse of the parameter related to a sexual selection strength behaves like an external field in the system and, as thus, is also a control parameter. The macroscopic effects of the biological parameters used in our model are a reminiscent of the behavior of thermodynamic quantities in a phase transition of an equilibrium physical system.

  16. Low Reynolds number kappa-epsilon and empirical transition models for oscillatory pipe flow and heat transfer. M.S. Thesis

    NASA Technical Reports Server (NTRS)

    Bauer, Christopher

    1993-01-01

    Stirling engine heat exchangers are shell-and-tube type with oscillatory flow (zero-mean velocity) for the inner fluid. This heat transfer process involves laminar-transition turbulent flow motions under oscillatory flow conditions. A low Reynolds number kappa-epsilon model, (Lam-Bremhorst form), was utilized in the present study to simulate fluid flow and heat transfer in a circular tube. An empirical transition model was used to activate the low Reynolds number k-e model at the appropriate time within the cycle for a given axial location within the tube. The computational results were compared with experimental flow and heat transfer data for: (1) velocity profiles, (2) kinetic energy of turbulence, (3) skin friction factor, (4) temperature profiles, and (5) wall heat flux. The experimental data were obtained for flow in a tube (38 mm diameter and 60 diameter long), with the maximum Reynolds number based on velocity being Re(sub max) = 11840, a dimensionless frequency (Valensi number) of Va = 80.2, at three axial locations X/D = 16, 30 and 44. The agreement between the computations and the experiment is excellent in the laminar portion of the cycle and good in the turbulent portion. Moreover, the location of transition was predicted accurately. The Low Reynolds Number kappa-epsilon model, together with an empirical transition model, is proposed herein to generate the wall heat flux values at different operating parameters than the experimental conditions. Those computational data can be used for testing the much simpler and less accurate one dimensional models utilized in 1-D Stirling Engine design codes.

  17. Free energy and phase transition of the matrix model on a plane wave

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hadizadeh, Shirin; Ramadanovic, Bojan; Semenoff, Gordon W.

    2005-03-15

    It has recently been observed that the weakly coupled plane-wave matrix model has a density of states which grows exponentially at high energy. This implies that the model has a phase transition. The transition appears to be of first order. However, its exact nature is sensitive to interactions. In this paper, we analyze the effect of interactions by computing the relevant parts of the effective potential for the Polyakov loop operator in the finite temperature plane-wave matrix model to three-loop order. We show that the phase transition is indeed of first order. We also compute the correction to the Hagedornmore » temperature to order two loops.« less

  18. The Functional Transitions Model: Maximizing Ability in the Context of Progressive Disability Associated with Alzheimer's Disease

    ERIC Educational Resources Information Center

    Slaughter, Susan; Bankes, Jane

    2007-01-01

    The Functional Transitions Model (FTM) integrates the theoretical notions of progressive functional decline associated with Alzheimer's disease (AD), excess disability, and transitions occurring intermittently along the trajectory of functional decline. Application of the Functional Transitions Model to clinical practice encompasses the paradox of…

  19. Modeled and Observed Transitions Between Rip Currents and Alongshore Flows

    NASA Astrophysics Data System (ADS)

    Moulton, M.; Elgar, S.; Warner, J. C.; Raubenheimer, B.

    2014-12-01

    Predictions of rip currents, alongshore currents, and the temporal transitions between these circulation patterns are important for swimmer safety and for estimating the transport of sediments, biota, and pollutants in the nearshore. Here, field observations are combined with hydrodynamic modeling to determine the dominant processes that lead rip currents to turn on and off with changing waves, bathymetry, and tidal elevation. Waves, currents, mean sea levels, and bathymetry were measured near and within five shore-perpendicular channels (on average 2-m deep, 30-m wide) that were dredged with the propellers of a landing craft at different times on a long straight Atlantic Ocean beach near Duck, NC in summer 2012. The circulation was measured for a range of incident wave conditions and channel sizes, and included rapid transitions between strong (0.5 to 1 m/s) rip current jets flowing offshore through the channels and alongshore currents flowing across the channels with no rip currents. Meandering alongshore currents (alongshore currents combined with an offshore jet at the downstream edge of the channel) also were observed. Circulation patterns near and within idealized rip channels simulated with COAWST (a three-dimensional phase-averaged model that couples ROMS and SWAN) are compared with the observations. In addition, the model is used to investigate the hydrodynamic response to a range of wave conditions (angle, height, period) and bathymetries (channel width, depth, and length; tidal elevations; shape of sandbar or terrace). Rip current speeds are largest for the deepest perturbations, and decrease as incident wave angles become more oblique. For obliquely incident waves, the rip currents are shifted in the direction of the alongshore flow, with an increasing shift for increasing alongshore current speed or increasing bathymetric perturbation depth.

  20. Universal phase transition in community detectability under a stochastic block model.

    PubMed

    Chen, Pin-Yu; Hero, Alfred O

    2015-03-01

    We prove the existence of an asymptotic phase-transition threshold on community detectability for the spectral modularity method [M. E. J. Newman, Phys. Rev. E 74, 036104 (2006) and Proc. Natl. Acad. Sci. (USA) 103, 8577 (2006)] under a stochastic block model. The phase transition on community detectability occurs as the intercommunity edge connection probability p grows. This phase transition separates a subcritical regime of small p, where modularity-based community detection successfully identifies the communities, from a supercritical regime of large p where successful community detection is impossible. We show that, as the community sizes become large, the asymptotic phase-transition threshold p* is equal to √[p1p2], where pi(i=1,2) is the within-community edge connection probability. Thus the phase-transition threshold is universal in the sense that it does not depend on the ratio of community sizes. The universal phase-transition phenomenon is validated by simulations for moderately sized communities. Using the derived expression for the phase-transition threshold, we propose an empirical method for estimating this threshold from real-world data.

  1. Digital soil mapping as a tool for quantifying state-and-transition models

    USDA-ARS?s Scientific Manuscript database

    Ecological sites and associated state-and-transition models (STMs) are rapidly becoming important land management tools in rangeland systems in the US and around the world. Descriptions of states and transitions are largely developed from expert knowledge and generally accepted species and community...

  2. Critical exponents of the explosive percolation transition

    NASA Astrophysics Data System (ADS)

    da Costa, R. A.; Dorogovtsev, S. N.; Goltsev, A. V.; Mendes, J. F. F.

    2014-04-01

    In a new type of percolation phase transition, which was observed in a set of nonequilibrium models, each new connection between vertices is chosen from a number of possibilities by an Achlioptas-like algorithm. This causes preferential merging of small components and delays the emergence of the percolation cluster. First simulations led to a conclusion that a percolation cluster in this irreversible process is born discontinuously, by a discontinuous phase transition, which results in the term "explosive percolation transition." We have shown that this transition is actually continuous (second order) though with an anomalously small critical exponent of the percolation cluster. Here we propose an efficient numerical method enabling us to find the critical exponents and other characteristics of this second-order transition for a representative set of explosive percolation models with different number of choices. The method is based on gluing together the numerical solutions of evolution equations for the cluster size distribution and power-law asymptotics. For each of the models, with high precision, we obtain critical exponents and the critical point.

  3. Glass transition and relaxation processes of nanocomposite polymer electrolytes.

    PubMed

    Money, Benson K; Hariharan, K; Swenson, Jan

    2012-07-05

    This study focus on the effect of δ-Al(2)O(3) nanofillers on the dc-conductivity, glass transition, and dielectric relaxations in the polymer electrolyte (PEO)(4):LiClO(4). The results show that there are three dielectric relaxation processes, α, β, and γ, in the systems, although the structural α-relaxation is hidden in the strong conductivity contribution and could therefore not be directly observed. However, by comparing an enhanced dc-conductivity, by approximately 2 orders of magnitude with 4 wt % δ-Al(2)O(3) added, with a decrease in calorimetric glass transition temperature, we are able to conclude that the dc-conductivity is directly coupled to the hidden α-relaxation, even in the presence of nanofillers (at least in the case of δ-Al(2)O(3) nanofillers at concentrations up to 4 wt %). This filler induced speeding up of the segmental polymer dynamics, i.e., the α-relaxation, can be explained by the nonattractive nature of the polymer-filler interactions, which enhance the "free volume" and mobility of polymer segments in the vicinity of filler surfaces.

  4. Phase transitions in the quadratic contact process on complex networks

    NASA Astrophysics Data System (ADS)

    Varghese, Chris; Durrett, Rick

    2013-06-01

    The quadratic contact process (QCP) is a natural extension of the well-studied linear contact process where infected (1) individuals infect susceptible (0) neighbors at rate λ and infected individuals recover (10) at rate 1. In the QCP, a combination of two 1's is required to effect a 01 change. We extend the study of the QCP, which so far has been limited to lattices, to complex networks. We define two versions of the QCP: vertex-centered (VQCP) and edge-centered (EQCP) with birth events 1-0-11-1-1 and 1-1-01-1-1, respectively, where “-” represents an edge. We investigate the effects of network topology by considering the QCP on random regular, Erdős-Rényi, and power-law random graphs. We perform mean-field calculations as well as simulations to find the steady-state fraction of occupied vertices as a function of the birth rate. We find that on the random regular and Erdős-Rényi graphs, there is a discontinuous phase transition with a region of bistability, whereas on the heavy-tailed power-law graph, the transition is continuous. The critical birth rate is found to be positive in the former but zero in the latter.

  5. Energy efficient engine: Turbine transition duct model technology report

    NASA Technical Reports Server (NTRS)

    Leach, K.; Thurlin, R.

    1982-01-01

    The Low-Pressure Turbine Transition Duct Model Technology Program was directed toward substantiating the aerodynamic definition of a turbine transition duct for the Energy Efficient Engine. This effort was successful in demonstrating an aerodynamically viable compact duct geometry and the performance benefits associated with a low camber low-pressure turbine inlet guide vane. The transition duct design for the flight propulsion system was tested and the pressure loss goal of 0.7 percent was verified. Also, strut fairing pressure distributions, as well as wall pressure coefficients, were in close agreement with analytical predictions. Duct modifications for the integrated core/low spool were also evaluated. The total pressure loss was 1.59 percent. Although the increase in exit area in this design produced higher wall loadings, reflecting a more aggressive aerodynamic design, pressure profiles showed no evidence of flow separation. Overall, the results acquired have provided pertinent design and diagnostic information for the design of a turbine transition duct for both the flight propulsion system and the integrated core/low spool.

  6. Extinction phase transitions in a model of ecological and evolutionary dynamics

    NASA Astrophysics Data System (ADS)

    Barghathi, Hatem; Tackkett, Skye; Vojta, Thomas

    2017-07-01

    We study the non-equilibrium phase transition between survival and extinction of spatially extended biological populations using an agent-based model. We especially focus on the effects of global temporal fluctuations of the environmental conditions, i.e., temporal disorder. Using large-scale Monte-Carlo simulations of up to 3 × 107 organisms and 105 generations, we find the extinction transition in time-independent environments to be in the well-known directed percolation universality class. In contrast, temporal disorder leads to a highly unusual extinction transition characterized by logarithmically slow population decay and enormous fluctuations even for large populations. The simulations provide strong evidence for this transition to be of exotic infinite-noise type, as recently predicted by a renormalization group theory. The transition is accompanied by temporal Griffiths phases featuring a power-law dependence of the life time on the population size.

  7. Noise-induced transitions and shifts in a climate-vegetation feedback model.

    PubMed

    Alexandrov, Dmitri V; Bashkirtseva, Irina A; Ryashko, Lev B

    2018-04-01

    Motivated by the extremely important role of the Earth's vegetation dynamics in climate changes, we study the stochastic variability of a simple climate-vegetation system. In the case of deterministic dynamics, the system has one stable equilibrium and limit cycle or two stable equilibria corresponding to two opposite (cold and warm) climate-vegetation states. These states are divided by a separatrix going across a point of unstable equilibrium. Some possible stochastic scenarios caused by different externally induced natural and anthropogenic processes inherit properties of deterministic behaviour and drastically change the system dynamics. We demonstrate that the system transitions across its separatrix occur with increasing noise intensity. The climate-vegetation system therewith fluctuates, transits and localizes in the vicinity of its attractor. We show that this phenomenon occurs within some critical range of noise intensities. A noise-induced shift into the range of smaller global average temperatures corresponding to substantial oscillations of the Earth's vegetation cover is revealed. Our analysis demonstrates that the climate-vegetation interactions essentially contribute to climate dynamics and should be taken into account in more precise and complex models of climate variability.

  8. Nonlinear modeling of crystal system transition of black phosphorus using continuum-DFT model.

    PubMed

    Setoodeh, A R; Farahmand, H

    2018-01-24

    In this paper, the nonlinear behavior of black phosphorus crystals is investigated in tandem with dispersion-corrected density functional theory (DFT-D) analysis under uniaxial loadings. From the identified anisotropic behavior of black phosphorus due to its morphological anisotropy, a hyperelastic anisotropic (HA) model named continuum-DFT is established to predict the nonlinear behavior of the material. In this respect, uniaxial Cauchy stresses are employed on both the DFT-D and HA models along the zig-zag and armchair directions. Simultaneously, the transition of the crystal system is recognized at about 4.5 GPa of the applied uniaxial tensile stress along the zig-zag direction on the DFT-D simulation in the nonlinear region. In order to develop the nonlinear continuum model, unknown constants are surveyed with the optimized least square technique. In this regard, the continuum model is obtained to reproduce the Cauchy stress-stretch and density of strain-stretch results of the DFT-D simulation. Consequently, the modified HA model is introduced to characterize the nonlinear behavior of black phosphorus along the zig-zag direction. More importantly, the specific transition of the crystal system is successfully predicted in the new modified continuum-DFT model. The results reveal that the multiscale continuum-DFT model is well defined to replicate the nonlinear behavior of black phosphorus along the zig-zag and armchair directions.

  9. Ares Upper Stage Processes to Implement Model Based Design - Going Paperless

    NASA Technical Reports Server (NTRS)

    Gregory, Melanie

    2012-01-01

    Computer-Aided Design (CAD) has all but replaced the drafting board for design work. Increased productivity and accuracy should be natural outcomes of using CAD. Going from paper drawings only to paper drawings based on CAD models to CAD models and no drawings, or Model Based Design (MBD), is a natural progression in today?s world. There are many advantages to MBD over traditional design methods. To make the most of those advantages, standards should be in place and the proper foundation should be laid prior to transitioning to MBD. However, without a full understanding of the implications of MBD and the proper control of the data, the advantages are greatly diminished. Transitioning from a paper design world to an electronic design world means re-thinking how information gets controlled at its origin and distributed from one point to another. It means design methodology is critical, especially for large projects. It means preparation of standardized parts and processes as well as strong communication between all parties in order to maximize the benefits of MBD.

  10. batman: BAsic Transit Model cAlculatioN in Python

    NASA Astrophysics Data System (ADS)

    Kreidberg, Laura

    2015-10-01

    batman provides fast calculation of exoplanet transit light curves and supports calculation of light curves for any radially symmetric stellar limb darkening law. It uses an integration algorithm for models that cannot be quickly calculated analytically, and in typical use, the batman Python package can calculate a million model light curves in well under ten minutes for any limb darkening profile.

  11. Right-hemispheric dominance for processing extended non-linguistic frequency transitions.

    PubMed

    McKibbin, Katherine; Elias, Lorin J; Saucier, Deborah M; Engebregston, Delaine

    2003-11-01

    The left hemisphere is specialized for most linguistic tasks and the right hemisphere is specialized for many non-linguistic tasks, but the cause of these functional asymmetries is unknown. One of the stimulus factors that appears to influence these asymmetries is the rate at which stimuli change. In the present experiment, 41 participants completed the Fused Dichotic Words Test (FDWT) and a non-linguistic Frequency Transition Task (FTT) wherein the Frequency Transitions (FTs) were either rapid (40 ms) or relatively slow (200 ms). There was a right hemisphere advantage for slow FTs when the change was at the front of the stimulus, but no corresponding left hemisphere advantage for the rapid FTs. There was no relationship between either FTT and the left hemisphere advantage exhibited on the FDWT. This finding provides support for the position that the right hemisphere dominates tasks that require temporal processing over relatively long periods of time.

  12. Elementary model of severe plastic deformation by KoBo process

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gusak, A.; Storozhuk, N.; Danielewski, M., E-mail: daniel@agh.edu.pl

    2014-01-21

    Self-consistent model of generation, interaction, and annihilation of point defects in the gradient of oscillating stresses is presented. This model describes the recently suggested method of severe plastic deformation by combination of pressure and oscillating rotations of the die along the billet axis (KoBo process). Model provides the existence of distinct zone of reduced viscosity with sharply increased concentration of point defects. This zone provides the high extrusion velocity. Presented model confirms that the Severe Plastic Deformation (SPD) in KoBo may be treated as non-equilibrium phase transition of abrupt drop of viscosity in rather well defined spatial zone. In thismore » very zone, an intensive lateral rotational movement proceeds together with generation of point defects which in self-organized manner make rotation possible by the decrease of viscosity. The special properties of material under KoBo version of SPD can be described without using the concepts of nonequilibrium grain boundaries, ballistic jumps and amorphization. The model can be extended to include different SPD processes.« less

  13. Simple Models for Airport Delays During Transition to a Trajectory-Based Air Traffic System

    NASA Astrophysics Data System (ADS)

    Brooker, Peter

    It is now widely recognised that a paradigm shift in air traffic control concepts is needed. This requires state-of-the-art innovative technologies, making much better use of the information in the air traffic management (ATM) system. These paradigm shifts go under the names of NextGen in the USA and SESAR in Europe, which inter alia will make dramatic changes to the nature of airport operations. A vital part of moving from an existing system to a new paradigm is the operational implications of the transition process. There would be business incentives for early aircraft fitment, it is generally safer to introduce new technologies gradually, and researchers are already proposing potential transition steps to the new system. Simple queuing theory models are used to establish rough quantitative estimates of the impact of the transition to a more efficient time-based navigational and ATM system. Such models are approximate, but they do offer insight into the broad implications of system change and its significant features. 4D-equipped aircraft in essence have a contract with the airport runway and, in return, they would get priority over any other aircraft waiting for use of the runway. The main operational feature examined here is the queuing delays affecting non-4D-equipped arrivals. These get a reasonable service if the proportion of 4D-equipped aircraft is low, but this can deteriorate markedly for high proportions, and be economically unviable. Preventative measures would be to limit the additional growth of 4D-equipped flights and/or to modify their contracts to provide sufficient space for the non-4D-equipped flights to operate without excessive delays. There is a potential for non-Poisson models, for which there is little in the literature, and for more complex models, e.g. grouping a succession of 4D-equipped aircraft as a batch.

  14. Systems Analysis of the Hydrogen Transition with HyTrans

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Leiby, Paul Newsome; Greene, David L; Bowman, David Charles

    2007-01-01

    The U.S. Federal government is carefully considering the merits and long-term prospects of hydrogen-fueled vehicles. NAS (1) has called for the careful application of systems analysis tools to structure the complex assessment required. Others, raising cautionary notes, question whether a consistent and plausible transition to hydrogen light-duty vehicles can identified (2) and whether that transition would, on balance, be environmentally preferred. Modeling the market transition to hydrogen-powered vehicles is an inherently complex process, encompassing hydrogen production, delivery and retailing, vehicle manufacturing, and vehicle choice and use. We describe the integration of key technological and market factors in a dynamic transitionmore » model, HyTrans. The usefulness of HyTrans and its predictions depends on three key factors: (1) the validity of the economic theories that underpin the model, (2) the authenticity with which the key processes are represented, and (3) the accuracy of specific parameter values used in the process representations. This paper summarizes the theoretical basis of HyTrans, and highlights the implications of key parameter specifications with sensitivity analysis.« less

  15. Calibration of the 7—Equation Transition Model for High Reynolds Flows at Low Mach

    NASA Astrophysics Data System (ADS)

    Colonia, S.; Leble, V.; Steijl, R.; Barakos, G.

    2016-09-01

    The numerical simulation of flows over large-scale wind turbine blades without considering the transition from laminar to fully turbulent flow may result in incorrect estimates of the blade loads and performance. Thanks to its relative simplicity and promising results, the Local-Correlation based Transition Modelling concept represents a valid way to include transitional effects into practical CFD simulations. However, the model involves coefficients that need tuning. In this paper, the γ—equation transition model is assessed and calibrated, for a wide range of Reynolds numbers at low Mach, as needed for wind turbine applications. An aerofoil is used to evaluate the original model and calibrate it; while a large scale wind turbine blade is employed to show that the calibrated model can lead to reliable solutions for complex three-dimensional flows. The calibrated model shows promising results for both two-dimensional and three-dimensional flows, even if cross-flow instabilities are neglected.

  16. Quality-by-Design (QbD): An integrated process analytical technology (PAT) approach for a dynamic pharmaceutical co-precipitation process characterization and process design space development.

    PubMed

    Wu, Huiquan; White, Maury; Khan, Mansoor A

    2011-02-28

    The aim of this work was to develop an integrated process analytical technology (PAT) approach for a dynamic pharmaceutical co-precipitation process characterization and design space development. A dynamic co-precipitation process by gradually introducing water to the ternary system of naproxen-Eudragit L100-alcohol was monitored at real-time in situ via Lasentec FBRM and PVM. 3D map of count-time-chord length revealed three distinguishable process stages: incubation, transition, and steady-state. The effects of high risk process variables (slurry temperature, stirring rate, and water addition rate) on both derived co-precipitation process rates and final chord-length-distribution were evaluated systematically using a 3(3) full factorial design. Critical process variables were identified via ANOVA for both transition and steady state. General linear models (GLM) were then used for parameter estimation for each critical variable. Clear trends about effects of each critical variable during transition and steady state were found by GLM and were interpreted using fundamental process principles and Nyvlt's transfer model. Neural network models were able to link process variables with response variables at transition and steady state with R(2) of 0.88-0.98. PVM images evidenced nucleation and crystal growth. Contour plots illustrated design space via critical process variables' ranges. It demonstrated the utility of integrated PAT approach for QbD development. Published by Elsevier B.V.

  17. Evolution of weighted complex bus transit networks with flow

    NASA Astrophysics Data System (ADS)

    Huang, Ailing; Xiong, Jie; Shen, Jinsheng; Guan, Wei

    2016-02-01

    Study on the intrinsic properties and evolutional mechanism of urban public transit networks (PTNs) has great significance for transit planning and control, particularly considering passengers’ dynamic behaviors. This paper presents an empirical analysis for exploring the complex properties of Beijing’s weighted bus transit network (BTN) based on passenger flow in L-space, and proposes a bi-level evolution model to simulate the development of transit routes from the view of complex network. The model is an iterative process that is driven by passengers’ travel demands and dual-controlled interest mechanism, which is composed of passengers’ spatio-temporal requirements and cost constraint of transit agencies. Also, the flow’s dynamic behaviors, including the evolutions of travel demand, sectional flow attracted by a new link and flow perturbation triggered in nearby routes, are taken into consideration in the evolutional process. We present the numerical experiment to validate the model, where the main parameters are estimated by using distribution functions that are deduced from real-world data. The results obtained have proven that our model can generate a BTN with complex properties, such as the scale-free behavior or small-world phenomenon, which shows an agreement with our empirical results. Our study’s results can be exploited to optimize the real BTN’s structure and improve the network’s robustness.

  18. An in vivo model of epithelial to mesenchymal transition reveals a mitogenic switch

    PubMed Central

    Jahn, Stephan C.; Law, Mary E.; Corsino, Patrick E.; Parker, Nicole N.; Pham, Kien; Davis, Bradley J.; Lu, Jianrong; Law, Brian K.

    2012-01-01

    The epithelial to mesenchymal transition (EMT) is a process by which differentiated epithelial cells transition to a mesenchymal phenotype. EMT enables the escape of epithelial cells from the rigid structural constraints of the tissue architecture to a phenotype more amenable to cell migration and, therefore, invasion and metastasis. We characterized an in vivo model of EMT and discovered that marked changes in mitogenic signaling occurred during this process. DNA microarray analysis revealed that the expression of a number of genes varied significantly between post-EMT and pre-EMT breast cancer cells. Post-EMT cancer cells upregulated mRNA encoding c-Met and the PDGF and LPA receptors, and acquired increased responsiveness to HGF, PDGF, and LPA. This rendered the post-EMT cells responsive to the growth inhibitory effects of HGF, PDGF, and LPA receptor inhibitors/antagonists. Furthermore, post- EMT cells exhibited decreased basal Raf and Erk phosphorylation, and in comparison to pre-EMT cells, their proliferation was poorly inhibited by a MEK inhibitor. These studies suggest that therapies need to be designed to target both pre-EMT and post-EMT cancer cells and that signaling changes in post- EMT cells may allow them to take advantage of paracrine signaling from the stroma in vivo. PMID:22906417

  19. Phase transition in a spatial Lotka-Volterra model

    NASA Astrophysics Data System (ADS)

    Szabó, György; Czárán, Tamás

    2001-06-01

    Spatial evolution is investigated in a simulated system of nine competing and mutating bacterium strains, which mimics the biochemical war among bacteria capable of producing two different bacteriocins (toxins) at most. Random sequential dynamics on a square lattice is governed by very symmetrical transition rules for neighborhood invasions of sensitive strains by killers, killers by resistants, and resistants by sensitives. The community of the nine possible toxicity/resistance types undergoes a critical phase transition as the uniform transmutation rates between the types decreases below a critical value Pc above that all the nine types of strains coexist with equal frequencies. Passing the critical mutation rate from above, the system collapses into one of three topologically identical (degenerated) states, each consisting of three strain types. Of the three possible final states each accrues with equal probability and all three maintain themselves in a self-organizing polydomain structure via cyclic invasions. Our Monte Carlo simulations support that this symmetry-breaking transition belongs to the universality class of the three-state Potts model.

  20. A Study of Grid Resolution, Transition and Turbulence Model Using the Transonic Simple Straked Delta Wing

    NASA Technical Reports Server (NTRS)

    Bartels, Robert E.

    2001-01-01

    Three-dimensional transonic flow over a delta wing is investigated using several turbulence models. The performance of linear eddy viscosity models and an explicit algebraic stress model is assessed at the start of vortex flow, and the results compared with experimental data. To assess the effect of transition location, computations that either fix transition aft of the leading edge or are fully turbulent are performed. These computations show that grid resolution, transition location and turbulence model significantly affect the 3D flowfield.

  1. Facility Will Help Transition Models Into Operations

    NASA Astrophysics Data System (ADS)

    Kumar, Mohi

    2009-02-01

    The U.S. National Oceanic and Atmospheric Administration's Space Weather Prediction Center (NOAA SWPC), in partnership with the U.S. Air Force Weather Agency (AFWA), is establishing a center to promote and facilitate the transition of space weather models to operations. The new facility, called the Developmental Testbed Center (DTC), will take models used by researchers and rigorously test them to see if they can withstand continued use as viable warning systems. If a model used in a space weather warning system crashes or fails to perform well, severe consequences can result. These include increased radiation risks to astronauts and people traveling on high-altitude flights, national security vulnerabilities from the loss of military satellite communications, and the cost of replacing damaged military and commercial spacecraft.

  2. Adolescents with Type 1 Diabetes: transition between diabetes services.

    PubMed

    Visentin, Kate; Koch, Tina; Kralik, Debbie

    2006-06-01

    The research aimed to develop a sustainable and coordinated approach to facilitating the transition between diabetes services for adolescents. The objectives were to: (1) involve key diabetes health delivery stakeholders in expressing their concerns and issues about current service delivery and ways to improve same, and (2) reveal from the perspective of the adolescents living with Type 1 Diabetes their experiences surrounding the process of transition. This paper presents research that sought to identify the major concerns and issues that stakeholders had about transition and to reveal the experience of transition for the adolescent with Type 1 Diabetes. Key representatives from seven public diabetes services in Adelaide, South Australia worked collaboratively to answer the objectives of this inquiry. Approach. Interview data were generated and analysed using a response focus framework provided by fourth generation evaluation research. In this study, the focus was on common concerns, claims and issues raised by health care professionals (n = 21) and adolescents (n = 10) aged between 15 and 18 years about transferring from children's to adult diabetes services. Data revealed education and dietetic advice was reactive rather than proactive and that the paediatric model of care is philosophically and practically different to the adult model of diabetes care. Three phases of transition were identified: preparation, formal transition and evaluation. Our findings indicated that these stages of transition were not being fully implemented in health units. The project findings have set the scene to establish a multidisciplinary working party to work collaboratively across agencies to develop effective transition pathways. The role of diabetes nurse educators and dietitians in South Australia is under-used throughout the transition process. Diabetes nurse educators are in an ideal position to prepare, coordinate and evaluate transitional processes.

  3. Many-body localization-delocalization transition in the quantum Sherrington-Kirkpatrick model

    NASA Astrophysics Data System (ADS)

    Mukherjee, Sudip; Nag, Sabyasachi; Garg, Arti

    2018-04-01

    We analyze the many-body localization- (MBL) to-delocalization transition in the Sherrington-Kirkpatrick (SK) model of Ising spin glass in the presence of a transverse field Γ . Based on energy-resolved analysis, which is of relevance for a closed quantum system, we show that the quantum SK model has many-body mobility edges separating the MBL phase, which is nonergodic and nonthermal, from the delocalized phase, which is ergodic and thermal. The range of the delocalized regime increases with an increase in the strength of Γ , and eventually for Γ larger than ΓCP the entire many-body spectrum is delocalized. We show that the Renyi entropy is almost independent of the system size in the MBL phase while the delocalized phase shows extensive Renyi entropy. We further obtain the spin-glass transition curve in the energy density ɛ -Γ plane from the collapse of the eigenstate spin susceptibility. We demonstrate that in most of the parameter regime, the spin-glass transition occurs close to the MBL transition, indicating that the spin-glass phase is nonergodic and nonthermal while the paramagnetic phase is delocalized and thermal.

  4. Simultaneous Characterization of Intravenous and Oral Pharmacokinetics of Lychnopholide in Rats by Transit Compartment Model.

    PubMed

    Lachi-Silva, Larissa; Sy, Sherwin K B; Voelkner, Alexander; de Sousa, João Paulo Barreto; Lopes, João Luis C; Silva, Denise B; Lopes, Norberto P; Kimura, Elza; Derendorf, Hartmut; Diniz, Andrea

    2015-08-01

    The pharmacokinetic properties of a new molecular entity are important aspects in evaluating the viability of the compound as a pharmacological agent. The sesquiterpene lactone lychnopholide exhibits important biological activities. The objective of this study was to characterize the pharmacokinetics of lychnopholide after intravenous administration of 1.65 mg/kg (n = 5) and oral administration of 3.3 mg/kg (n = 3) lychnopholide in rats (0.2 ± 0.02 kg in weight) through nonlinear mixed effects modeling and non-compartmental pharmacokinetic analysis. A highly sensitive analytical method was used to quantify the plasma lychnopholide concentrations in rats. Plasma protein binding of this compound was over 99 % as determined by a filtration method. A two-compartment body model plus three transit compartments to characterize the absorption process best described the disposition of lychnopholide after both routes of administration. The oral bioavailability was approximately 68 %. The clearance was 0.131 l/min and intercompartmental clearance was 0.171 l/min; steady-state volume of distribution was 4.83 l. The mean transit time for the absorption process was 9.15 minutes. No flip-flop phenomenon was observed after oral administration. The pharmacokinetic properties are favorable for further development of lychnopholide as a potential oral pharmacological agent. Georg Thieme Verlag KG Stuttgart · New York.

  5. Transition model for ricin-aptamer interactions with multiple pathways and energy barriers

    NASA Astrophysics Data System (ADS)

    Wang, Bin; Xu, Bingqian

    2014-02-01

    We develop a transition model to interpret single-molecule ricin-aptamer interactions with multiple unbinding pathways and energy barriers measured by atomic force microscopy dynamic force spectroscopy. Molecular simulations establish the relationship between binding conformations and the corresponding unbinding pathways. Each unbinding pathway follows a Bell-Evans multiple-barrier model. Markov-type transition matrices are developed to analyze the redistribution of unbinding events among the pathways under different loading rates. Our study provides detailed information about complex behaviors in ricin-aptamer unbinding events.

  6. An evaluation of the accuracy of the Federal Transit Administration approved, groundborne noise and vibration prediction model for rail transit systems; a case study for a new subway line using post construction, transit operation measurements

    NASA Astrophysics Data System (ADS)

    Carman, Richard A.; Reyes, Carlos H.

    2005-09-01

    The groundborne noise and vibration model developed by Nelson and Saurenman in 1984, now recognized by the Federal Transit Administration as the approved model for new transit system facilities, is entering its third decade of use by engineers and consultants in the transit industry. The accuracy of the model has been explored in the past (e.g., Carman and Wolfe). New data obtained for a recently completed extension to a major heavy rail transit system provides an opportunity to evaluate the accuracy of the model once more. During the engineering design phase of the project, noise and vibration predictions were performed for numerous buildings adjacent to the new subway line. The values predicted by the model were used to determine the need for and type of noise and/or vibration control measures. After the start of transit operations on the new line, noise and vibration measurements were made inside several of the buildings to determine whether the criteria were in fact achieved. The measurement results are compared with the values predicted by the model. The predicted and measured, overall noise and vibration levels show very good agreement, whereas the spectral comparisons indicate some differences. Possible reasons for these differences are offered.

  7. Thermomechanical modeling of the Colorado Plateau-Basin and range transition zone

    NASA Technical Reports Server (NTRS)

    Londe, M. D.

    1985-01-01

    The Colorado Plateau (CP) basin and range (B & R) boundary is marked by a transition zone on the order of 75 to 150 km in width. As one moves westward across this transition from the CP interior to the B & R there is a variation in the surface topography, surface heat flow, Bouguer gravity, seismicity, and crustal structure. This transition extends eastward into the western CP from the Wastach-Hurricane fault line and is largely coincident with the high plateaus of Utah and the Wasatch Mountains. It has been suggested that this transition zone marks a thermal and tectonic encroachment of the CP by the B & R. A simple two dimensional numerical model of the thermal regime for the transition zone was constructed to test the hypothesis that the observed geophysical signatures across the transition are due to lateral heat conduction from steady state uniform extension within the B & R lithosphere. Surface heat flow, uplift due to flexure from thermal buoyant loading, and regional Bouguer gravity are computed for various extension rates, crustal structures, and compensation depths.

  8. Nanoscale phase transition behavior of shape memory alloys — closed form solution of 1D effective modelling

    NASA Astrophysics Data System (ADS)

    Li, M. P.; Sun, Q. P.

    2018-01-01

    We investigate the roles of grain size (lg) and grain boundary thickness (lb) on the stress-induced phase transition (PT) behaviors of nanocrystalline shape memory alloys (SMAs) by using a Core-shell type "crystallite-amorphous composite" model. A non-dimensionalized length scale lbarg(=lg /lb) is identified as the governing parameter which is indicative of the energy competition between the crystallite and the grain boundary. Closed form analytical solutions of a reduced effective 1D model with embedded microstructure length scales of lg and lb are presented in this paper. It is shown that, with lbarg reduction, the energy of the elastic non-transformable grain boundary will gradually become dominant in the phase transition process, and eventually bring fundamental changes of the deformation behaviors: breakdown of two-phase coexistence and vanishing of superelastic hysteresis. The predictions are supported by experimental data of nanocrystalline NiTi SMAs.

  9. Modeling texture transitions in cholesteric liquid crystal droplets

    NASA Astrophysics Data System (ADS)

    Selinger, Robin; Gimenez-Pinto, Vianney; Lu, Shin-Ying; Selinger, Jonathan; Konya, Andrew

    2012-02-01

    Cholesteric liquid crystals can be switched reversibly between planar and focal-conic textures, a property enabling their application in bistable displays, liquid crystal writing tablets, e-books, and color switching ``e-skins.'' To explore voltage-pulse induced switching in cholesteric droplets, we perform simulation studies of director dynamics in three dimensions. Electrostatics calculations are solved at each time step using an iterative relaxation method. We demonstrate that as expected, a low amplitude pulse drives the transition from planar to focal conic, while a high amplitude pulse drives the transition from focal conic back to the planar state. We use the model to explore the effects of droplet shape, aspect ratio, and anchoring conditions, with the goal of minimizing both response time and energy consumption.

  10. Business Process Design Method Based on Business Event Model for Enterprise Information System Integration

    NASA Astrophysics Data System (ADS)

    Kobayashi, Takashi; Komoda, Norihisa

    The traditional business process design methods, in which the usecase is the most typical, have no useful framework to design the activity sequence with. Therefore, the design efficiency and quality vary widely according to the designer’s experience and skill. In this paper, to solve this problem, we propose the business events and their state transition model (a basic business event model) based on the language/action perspective, which is the result in the cognitive science domain. In the business process design, using this model, we decide event occurrence conditions so that every event synchronizes with each other. We also propose the design pattern to decide the event occurrence condition (a business event improvement strategy). Lastly, we apply the business process design method based on the business event model and the business event improvement strategy to the credit card issue process and estimate its effect.

  11. Latent Transition Analysis with a Mixture Item Response Theory Measurement Model

    ERIC Educational Resources Information Center

    Cho, Sun-Joo; Cohen, Allan S.; Kim, Seock-Ho; Bottge, Brian

    2010-01-01

    A latent transition analysis (LTA) model was described with a mixture Rasch model (MRM) as the measurement model. Unlike the LTA, which was developed with a latent class measurement model, the LTA-MRM permits within-class variability on the latent variable, making it more useful for measuring treatment effects within latent classes. A simulation…

  12. Solvable multistate model of Landau-Zener transitions in cavity QED

    DOE PAGES

    Sinitsyn, Nikolai; Li, Fuxiang

    2016-06-29

    We consider the model of a single optical cavity mode interacting with two-level systems (spins) driven by a linearly time-dependent field. When this field passes through values at which spin energy level splittings become comparable to spin coupling to the optical mode, a cascade of Landau-Zener (LZ) transitions leads to co-flips of spins in exchange for photons of the cavity. We derive exact transition probabilities between different diabatic states induced by such a sweep of the field.

  13. Dark matter and electroweak phase transition in the mixed scalar dark matter model

    NASA Astrophysics Data System (ADS)

    Liu, Xuewen; Bian, Ligong

    2018-03-01

    We study the electroweak phase transition in the framework of the scalar singlet-doublet mixed dark matter model, in which the particle dark matter candidate is the lightest neutral Higgs that comprises the C P -even component of the inert doublet and a singlet scalar. The dark matter can be dominated by the inert doublet or singlet scalar depending on the mixing. We present several benchmark models to investigate the two situations after imposing several theoretical and experimental constraints. An additional singlet scalar and the inert doublet drive the electroweak phase transition to be strongly first order. A strong first-order electroweak phase transition and a viable dark matter candidate can be accomplished in two benchmark models simultaneously, for which a proper mass splitting among the neutral and charged Higgs masses is needed.

  14. Integrating Ecosystem Carbon Dynamics into State-and-Transition Simulation Models of Land Use/Land Cover Change

    NASA Astrophysics Data System (ADS)

    Sleeter, B. M.; Daniel, C.; Frid, L.; Fortin, M. J.

    2016-12-01

    State-and-transition simulation models (STSMs) provide a general approach for incorporating uncertainty into forecasts of landscape change. Using a Monte Carlo approach, STSMs generate spatially-explicit projections of the state of a landscape based upon probabilistic transitions defined between states. While STSMs are based on the basic principles of Markov chains, they have additional properties that make them applicable to a wide range of questions and types of landscapes. A current limitation of STSMs is that they are only able to track the fate of discrete state variables, such as land use/land cover (LULC) classes. There are some landscape modelling questions, however, for which continuous state variables - for example carbon biomass - are also required. Here we present a new approach for integrating continuous state variables into spatially-explicit STSMs. Specifically we allow any number of continuous state variables to be defined for each spatial cell in our simulations; the value of each continuous variable is then simulated forward in discrete time as a stochastic process based upon defined rates of change between variables. These rates can be defined as a function of the realized states and transitions of each cell in the STSM, thus providing a connection between the continuous variables and the dynamics of the landscape. We demonstrate this new approach by (1) developing a simple IPCC Tier 3 compliant model of ecosystem carbon biomass, where the continuous state variables are defined as terrestrial carbon biomass pools and the rates of change as carbon fluxes between pools, and (2) integrating this carbon model with an existing LULC change model for the state of Hawaii, USA.

  15. A Framework for Supporting Organizational Transition Processes Towards Sustainable Energy Systems

    NASA Astrophysics Data System (ADS)

    Buch, Rajesh

    Economic development over the last century has driven a tripling of the world's population, a twenty-fold increase in fossil fuel consumption, and a tripling of traditional biomass consumption. The associated broad income and wealth inequities are retaining over 2 billion people in poverty. Adding to this, fossil fuel combustion is impacting the environment across spatial and temporal scales and the cost of energy is outpacing all other variable costs for most industries. With 60% of world energy delivered in 2008 consumed by the commercial and industrial sector, the fragmented and disparate energy-related decision making within organizations are largely responsible for the inefficient and impacting use of energy resources. The global transition towards sustainable development will require the collective efforts of national, regional, and local governments, institutions, the private sector, and a well-informed public. The leadership role in this transition could be provided by private and public sector organizations, by way of sustainability-oriented organizations, cultures, and infrastructure. The diversity in literature exemplifies the developing nature of sustainability science, with most sustainability assessment approaches and frameworks lacking transformational characteristics, tending to focus on analytical methods. In general, some shortfalls in sustainability assessment processes include lack of: · thorough stakeholder participation in systems and stakeholder mapping, · participatory envisioning of future sustainable states, · normative aggregation of results to provide an overall measure of sustainability, and · influence within strategic decision-making processes. Specific to energy sustainability assessments, while some authors aggregate results to provide overall sustainability scores, assessments have focused solely on energy supply scenarios, while including the deficits discussed above. This paper presents a framework for supporting

  16. The transition from diffuse to focused extension: Modeled evolution of the West Antarctic Rift system

    NASA Astrophysics Data System (ADS)

    Huerta, Audrey D.; Harry, Dennis L.

    2007-03-01

    Two distinct stages of extension are recognized in the West Antarctic Rift system (WARS). During the first stage, beginning in the Late Cretaceous, extension was broadly distributed throughout much of West Antarctica. A second stage of extension in the late Paleogene was focused primarily in the Victoria Land Basin, near the boundary with the East Antarctic craton. The transition to focused extension was roughly coeval with volcanic activity and strike-slip faulting in the adjacent Transantarctic Mountains. This spatial and temporal correspondence suggests that the transition in extensional style could be the result of a change in plate motions or impingement of a plume. Here we use finite element models to study the processes and conditions responsible for the two-stage evolution of rifting in the WARS. Model results indicate that the transition from a prolonged period of broadly distributed extension to a later period of focused rifting did not require a change in the regional stress regime (changes in plate motion), or deep mantle thermal state (impingement of a plume). Instead, we attribute the transition from diffuse to focused extension to an early stage dominated by the initially weak accreted lithosphere of West Antarctica, and a later stage that concentrated around a secondary weakness located at the boundary between the juvenile West Antarctica lithosphere and Precambrian East Antarctic craton. The modeled transition in extension from the initially weak West Antarctica region to the secondary weakness at the West Antarctic-East Antarctic boundary is precipitated by strengthening of the West Antarctica lithosphere during syn-extensional thinning and cooling. The modeled syn-extensional strengthening of the WARS lithosphere promotes a wide-rift mode of extension between 105 and ˜ 65 Ma. By ˜ 65 Ma most of the extending WARS region becomes stronger than the area immediately adjacent to the East Antarctic craton and extension becomes concentrated near the

  17. The NASA Short-term Prediction Research and Transition (SPoRT) Center: A Collaborative Model for Accelerating Research into Operations

    NASA Technical Reports Server (NTRS)

    Goodman, S. J.; Lapenta, W.; Jedlovec, G.; Dodge, J.; Bradshaw, T.

    2003-01-01

    The NASA Short-term Prediction Research and Transition (SPoRT) Center in Huntsville, Alabama was created to accelerate the infusion of NASA earth science observations, data assimilation and modeling research into NWS forecast operations and decision-making. The principal focus of experimental products is on the regional scale with an emphasis on forecast improvements on a time scale of 0-24 hours. The SPoRT Center research is aligned with the regional prediction objectives of the US Weather Research Program dealing with 0-1 day forecast issues ranging from convective initiation to 24-hr quantitative precipitation forecasting. The SPoRT Center, together with its other interagency partners, universities, and the NASA/NOAA Joint Center for Satellite Data Assimilation, provides a means and a process to effectively transition NASA Earth Science Enterprise observations and technology to National Weather Service operations and decision makers at both the global/national and regional scales. This paper describes the process for the transition of experimental products into forecast operations, current products undergoing assessment by forecasters, and plans for the future.

  18. Mathematical modelling of the antibiotic-induced morphological transition of Pseudomonas aeruginosa

    PubMed Central

    Keen, Emma; Smith, David J.

    2018-01-01

    Here we formulate a mechanistic mathematical model to describe the growth dynamics of P. aeruginosa in the presence of the β-lactam antibiotic meropenem. The model is mechanistic in the sense that carrying capacity is taken into account through the dynamics of nutrient availability rather than via logistic growth. In accordance with our experimental results we incorporate a sub-population of cells, differing in morphology from the normal bacillary shape of P. aeruginosa bacteria, which we assume have immunity from direct antibiotic action. By fitting this model to experimental data we obtain parameter values that give insight into the growth of a bacterial population that includes different cell morphologies. The analysis of two parameters sets, that produce different long term behaviour, allows us to manipulate the system theoretically in order to explore the advantages of a shape transition that may potentially be a mechanism that allows P. aeruginosa to withstand antibiotic effects. Our results suggest that inhibition of this shape transition may be detrimental to bacterial growth and thus suggest that the transition may be a defensive mechanism implemented by bacterial machinery. In addition to this we provide strong theoretical evidence for the potential therapeutic strategy of using antimicrobial peptides (AMPs) in combination with meropenem. This proposed combination therapy exploits the shape transition as AMPs induce cell lysis by forming pores in the cytoplasmic membrane, which becomes exposed in the spherical cells. PMID:29481562

  19. Modeling and Simulating Passenger Behavior for a Station Closure in a Rail Transit Network

    PubMed Central

    Yin, Haodong; Han, Baoming; Li, Dewei; Wu, Jianjun; Sun, Huijun

    2016-01-01

    A station closure is an abnormal operational situation in which the entrances or exits of a rail transit station have to be closed for some time due to an unexpected incident. A novel approach is developed to estimate the impacts of the alternative station closure scenarios on both passenger behavioral choices at the individual level and passenger demand at the disaggregate level in a rail transit network. Therefore, the contributions of this study are two-fold: (1) A basic passenger behavior optimization model is mathematically constructed based on 0–1 integer programming to describe passengers’ responses to alternative origin station closure scenarios and destination station closure scenarios; this model also considers the availability of multi-mode transportation and the uncertain duration of the station closure; (2) An integrated solution algorithm based on the passenger simulation is developed to solve the proposed model and to estimate the effects of a station closure on passenger demand in a rail transit network. Furthermore, 13 groups of numerical experiments based on the Beijing rail transit network are performed as case studies with 2,074,267 records of smart card data. The comparisons of the model outputs and the manual survey show that the accuracy of our proposed behavior optimization model is approximately 80%. The results also show that our model can be used to capture the passenger behavior and to quantitatively estimate the effects of alternative closure scenarios on passenger flow demand for the rail transit network. Moreover, the closure duration and its overestimation greatly influence the individual behavioral choices of the affected passengers and the passenger demand. Furthermore, if the rail transit operator can more accurately estimate the closure duration (namely, as g approaches 1), the impact of the closure can be somewhat mitigated. PMID:27935963

  20. Modeling and Simulating Passenger Behavior for a Station Closure in a Rail Transit Network.

    PubMed

    Yin, Haodong; Han, Baoming; Li, Dewei; Wu, Jianjun; Sun, Huijun

    2016-01-01

    A station closure is an abnormal operational situation in which the entrances or exits of a rail transit station have to be closed for some time due to an unexpected incident. A novel approach is developed to estimate the impacts of the alternative station closure scenarios on both passenger behavioral choices at the individual level and passenger demand at the disaggregate level in a rail transit network. Therefore, the contributions of this study are two-fold: (1) A basic passenger behavior optimization model is mathematically constructed based on 0-1 integer programming to describe passengers' responses to alternative origin station closure scenarios and destination station closure scenarios; this model also considers the availability of multi-mode transportation and the uncertain duration of the station closure; (2) An integrated solution algorithm based on the passenger simulation is developed to solve the proposed model and to estimate the effects of a station closure on passenger demand in a rail transit network. Furthermore, 13 groups of numerical experiments based on the Beijing rail transit network are performed as case studies with 2,074,267 records of smart card data. The comparisons of the model outputs and the manual survey show that the accuracy of our proposed behavior optimization model is approximately 80%. The results also show that our model can be used to capture the passenger behavior and to quantitatively estimate the effects of alternative closure scenarios on passenger flow demand for the rail transit network. Moreover, the closure duration and its overestimation greatly influence the individual behavioral choices of the affected passengers and the passenger demand. Furthermore, if the rail transit operator can more accurately estimate the closure duration (namely, as g approaches 1), the impact of the closure can be somewhat mitigated.

  1. Transition mixing study

    NASA Technical Reports Server (NTRS)

    Reynolds, R.; White, C.

    1986-01-01

    A computer model capable of analyzing the flow field in the transition liner of small gas turbine engines is developed. A FORTRAN code has been assembled from existing codes and physical submodels and used to predict the flow in several test geometries which contain characteristics similar to transition liners, and for which experimental data was available. Comparisons between the predictions and measurements indicate that the code produces qualitative results but that the turbulence models, both K-E and algebraic Reynolds Stress, underestimate the cross-stream diffusion. The code has also been used to perform a numerical experiment to examine the effect of a variety of parameters on the mixing process in transition liners. Comparisons illustrate that geometries with significant curvature show a drift of the jet trajectory toward the convex wall and weaker wake region vortices and decreased penetration for jets located on the convex wall of the liner, when compared to jets located on concave walls. Also shown were the approximate equivalency of angled slots and round holes and a technique by which jet mixing correlations developed for rectangular channels can be used for can geometries.

  2. Modeling the hepatitis A epidemiological transition in Thailand.

    PubMed

    Van Effelterre, Thierry; Marano, Cinzia; Jacobsen, Kathryn H

    2016-01-20

    In most low- and middle-income countries, hepatitis A virus (HAV) is shifting or expected to shift from high endemicity to intermediate or low endemicity. A decreased risk of HAV infection will cause an increase in the average age at infection and will therefore increase the proportion of infections that results in severe disease. Mathematical models can provide insights into the factors contributing to this epidemiological transition. An MSLIR compartmental dynamic transmission model stratified by age and setting (rural and urban) was developed and calibrated with demographic, environmental, and epidemiological data from Thailand. HAV transmission was modeled as a function of urbanization and access to clean drinking water. The model was used to project various epidemiological measures. The age at midpoint of population immunity remains considerably younger in rural areas than in urban areas. The mean age of symptomatic hepatitis A infection in Thailand has shifted from childhood toward early adulthood in rural areas and is transitioning from early adulthood toward middle adulthood in urban areas. The model showed a significant decrease in incidence rates of total and symptomatic infections in rural and urban settings in Thailand over the past several decades as water access has increased, although the overall incidence rate of symptomatic HAV is projected to slightly increase in the coming decades. Modeling the relationship between water, urbanization, and HAV endemicity is a novel approach in the estimation of HAV epidemiological trends and future projections. This approach provides insights about the shifting HAV epidemiology and could be used to evaluate the public health impact of vaccination and other interventions in a diversity of settings. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

  3. Distress in the Transition Process: The Role of Loss, Community, and Coping

    ERIC Educational Resources Information Center

    Budge, Stephanie L.

    2011-01-01

    Given the extensiveness of rejection and discrimination that transgender individuals experience (Lombardi, Wilchins, Priesing, & Malouf, 2001), the purpose of the current study was to examine the process of coping and how this relates to well-being at different stages of the gender transition. A total of 357 transsexual individuals (n = 226…

  4. The Transition Process for Adolescents with Learning Disabilities: Perspectives of Five Families

    ERIC Educational Resources Information Center

    Fullarton, Stephanie; Duquette, Cheryll

    2015-01-01

    This qualitative study examines, from the perspective of the families, the transition process to employment or postsecondary education for adolescents with learning disabilities (LDs) and the interplay of the roles of parents, students with LDs, and teachers. Using a case study design, series of three in-depth interviews were conducted with five…

  5. Modeling the Collisional-Plastic Stress Transition for Bin Discharge of Granular Material

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Pannala, Sreekanth; Daw, C Stuart; FINNEY, Charles E A

    2009-01-01

    We propose a heuristic model for the transition between collisional and frictional/plastic stresses in the flow of granular material. Our approach is based on a physically motivated, nonlinear blending function that produces a weighted average of the limiting stresses, depending on the local void fraction in the flow field. Previously published stress models are utilized to describe the behavior in the collisional (Lun et al., 1984) and quasi-static limits (Schaeffer, 1987 and Syamlal et al., 1993). Sigmoidal and hyperbolic tangent functions are used to mimic the observed smooth yet rapid transition between the collisional and plastic stress zones. We implementmore » our stress transition model in an opensource multiphase flow solver, MFIX (Multiphase Flow with Interphase eXchanges, www.mfix.org) and demonstrate its application to a standard bin discharge problem. The model s effectiveness is illustrated by comparing computational predictions to the experimentally derived Beverloo correlation. With the correct choice of function parameters, the model predicts bin discharge rates within the error margins of the Beverloo correlation and is more accurate than one of the alternative granular stress models proposed in the literature. Although a second granular stress model in the literature is also reasonably consistent with the Beverloo correlation, we propose that our alternative blending function is likely to be more adaptable to situations with more complex solids properties (e.g., sticky solids).« less

  6. Mixed-order phase transition in a two-step contagion model with a single infectious seed.

    PubMed

    Choi, Wonjun; Lee, Deokjae; Kahng, B

    2017-02-01

    Percolation is known as one of the most robust continuous transitions, because its occupation rule is intrinsically local. As one of the ways to break the robustness, occupation is allowed to more than one species of particles and they occupy cooperatively. This generalized percolation model undergoes a discontinuous transition. Here we investigate an epidemic model with two contagion steps and characterize its phase transition analytically and numerically. We find that even though the order parameter jumps at a transition point r_{c}, then increases continuously, it does not exhibit any critical behavior: the fluctuations of the order parameter do not diverge at r_{c}. However, critical behavior appears in mean outbreak size, which diverges at the transition point in a manner that the ordinary percolation shows. Such a type of phase transition is regarded as a mixed-order phase transition. We also obtain scaling relations of cascade outbreak statistics when the order parameter jumps at r_{c}.

  7. Quantum phase transition and quench dynamics in the anisotropic Rabi model

    NASA Astrophysics Data System (ADS)

    Shen, Li-Tuo; Yang, Zhen-Biao; Wu, Huai-Zhi; Zheng, Shi-Biao

    2017-01-01

    We investigate the quantum phase transition (QPT) and quench dynamics in the anisotropic Rabi model when the ratio of the qubit transition frequency to the oscillator frequency approaches infinity. Based on the Schrieffer-Wolff transformation, we find an anti-Hermitian operator that maps the original Hamiltonian into a one-dimensional oscillator Hamiltonian within the spin-down subspace. We analytically derive the eigenenergy and eigenstate of the normal and superradiant phases and demonstrate that the system undergoes a second-order quantum phase transition at a critical border. The critical border is a straight line in a two-dimensional parameter space which essentially extends the dimensionality of QPT in the Rabi model. By combining the Kibble-Zurek mechanism and the adiabatic dynamics method, we find that the residual energy vanishes as the quench time tends to zero, which is a sharp contrast to the universal scaling where the residual energy diverges in the same limit.

  8. A Shunt Model of the Inner Medullary Nephron with Pre-Bend Transitions

    NASA Astrophysics Data System (ADS)

    Gonzalez, M. T.; Hegarty, A. F.; Thomas, S. R.

    2009-09-01

    Mathematical models of the renal medulla face the problem of representing water and solute transfer among tens of thousands of nephrons and blood vessels of various lengths, arranged in countercurrent fashion. Published models fall into two broad categories with respect to this issue: multi-nephron models, which explicitly represent a large number of individual nephrons, or lumped models with virtual shunts that represent the turning back of nephrons and vessels at varying depths. Shunt models have the advantage of a compact description and relatively rapid execution time but are ill-suited to faithfully represent features such as prebend transitions of epithelial permeabilities in nephrons of different lengths. A new shunt model approach that can accommodate pre-bend transitions of nephrons at all medullary depths is presented in this work together with the results of simulation of predicted flows and concentrations.

  9. Solid-solid collapse transition in a two dimensional model molecular system.

    PubMed

    Singh, Rakesh S; Bagchi, Biman

    2013-11-21

    Solid-solid collapse transition in open framework structures is ubiquitous in nature. The real difficulty in understanding detailed microscopic aspects of such transitions in molecular systems arises from the interplay between different energy and length scales involved in molecular systems, often mediated through a solvent. In this work we employ Monte-Carlo simulation to study the collapse transition in a model molecular system interacting via both isotropic as well as anisotropic interactions having different length and energy scales. The model we use is known as Mercedes-Benz (MB), which, for a specific set of parameters, sustains two solid phases: honeycomb and oblique. In order to study the temperature induced collapse transition, we start with a metastable honeycomb solid and induce transition by increasing temperature. High density oblique solid so formed has two characteristic length scales corresponding to isotropic and anisotropic parts of interaction potential. Contrary to the common belief and classical nucleation theory, interestingly, we find linear strip-like nucleating clusters having significantly different order and average coordination number than the bulk stable phase. In the early stage of growth, the cluster grows as a linear strip, followed by branched and ring-like strips. The geometry of growing cluster is a consequence of the delicate balance between two types of interactions, which enables the dominance of stabilizing energy over destabilizing surface energy. The nucleus of stable oblique phase is wetted by intermediate order particles, which minimizes the surface free energy. In the case of pressure induced transition at low temperature the collapsed state is a disordered solid. The disordered solid phase has diverse local quasi-stable structures along with oblique-solid like domains.

  10. Solid-solid collapse transition in a two dimensional model molecular system

    NASA Astrophysics Data System (ADS)

    Singh, Rakesh S.; Bagchi, Biman

    2013-11-01

    Solid-solid collapse transition in open framework structures is ubiquitous in nature. The real difficulty in understanding detailed microscopic aspects of such transitions in molecular systems arises from the interplay between different energy and length scales involved in molecular systems, often mediated through a solvent. In this work we employ Monte-Carlo simulation to study the collapse transition in a model molecular system interacting via both isotropic as well as anisotropic interactions having different length and energy scales. The model we use is known as Mercedes-Benz (MB), which, for a specific set of parameters, sustains two solid phases: honeycomb and oblique. In order to study the temperature induced collapse transition, we start with a metastable honeycomb solid and induce transition by increasing temperature. High density oblique solid so formed has two characteristic length scales corresponding to isotropic and anisotropic parts of interaction potential. Contrary to the common belief and classical nucleation theory, interestingly, we find linear strip-like nucleating clusters having significantly different order and average coordination number than the bulk stable phase. In the early stage of growth, the cluster grows as a linear strip, followed by branched and ring-like strips. The geometry of growing cluster is a consequence of the delicate balance between two types of interactions, which enables the dominance of stabilizing energy over destabilizing surface energy. The nucleus of stable oblique phase is wetted by intermediate order particles, which minimizes the surface free energy. In the case of pressure induced transition at low temperature the collapsed state is a disordered solid. The disordered solid phase has diverse local quasi-stable structures along with oblique-solid like domains.

  11. Cortical processing of dynamic sound envelope transitions.

    PubMed

    Zhou, Yi; Wang, Xiaoqin

    2010-12-08

    Slow envelope fluctuations in the range of 2-20 Hz provide important segmental cues for processing communication sounds. For a successful segmentation, a neural processor must capture envelope features associated with the rise and fall of signal energy, a process that is often challenged by the interference of background noise. This study investigated the neural representations of slowly varying envelopes in quiet and in background noise in the primary auditory cortex (A1) of awake marmoset monkeys. We characterized envelope features based on the local average and rate of change of sound level in envelope waveforms and identified envelope features to which neurons were selective by reverse correlation. Our results showed that envelope feature selectivity of A1 neurons was correlated with the degree of nonmonotonicity in their static rate-level functions. Nonmonotonic neurons exhibited greater feature selectivity than monotonic neurons in quiet and in background noise. The diverse envelope feature selectivity decreased spike-timing correlation among A1 neurons in response to the same envelope waveforms. As a result, the variability, but not the average, of the ensemble responses of A1 neurons represented more faithfully the dynamic transitions in low-frequency sound envelopes both in quiet and in background noise.

  12. Community-wide validation of geospace model local K-index predictions to support model transition to operations

    NASA Astrophysics Data System (ADS)

    Glocer, A.; Rastätter, L.; Kuznetsova, M.; Pulkkinen, A.; Singer, H. J.; Balch, C.; Weimer, D.; Welling, D.; Wiltberger, M.; Raeder, J.; Weigel, R. S.; McCollough, J.; Wing, S.

    2016-07-01

    We present the latest result of a community-wide space weather model validation effort coordinated among the Community Coordinated Modeling Center (CCMC), NOAA Space Weather Prediction Center (SWPC), model developers, and the broader science community. Validation of geospace models is a critical activity for both building confidence in the science results produced by the models and in assessing the suitability of the models for transition to operations. Indeed, a primary motivation of this work is supporting NOAA/SWPC's effort to select a model or models to be transitioned into operations. Our validation efforts focus on the ability of the models to reproduce a regional index of geomagnetic disturbance, the local K-index. Our analysis includes six events representing a range of geomagnetic activity conditions and six geomagnetic observatories representing midlatitude and high-latitude locations. Contingency tables, skill scores, and distribution metrics are used for the quantitative analysis of model performance. We consider model performance on an event-by-event basis, aggregated over events, at specific station locations, and separated into high-latitude and midlatitude domains. A summary of results is presented in this report, and an online tool for detailed analysis is available at the CCMC.

  13. Community-Wide Validation of Geospace Model Local K-Index Predictions to Support Model Transition to Operations

    NASA Technical Reports Server (NTRS)

    Glocer, A.; Rastaetter, L.; Kuznetsova, M.; Pulkkinen, A.; Singer, H. J.; Balch, C.; Weimer, D.; Welling, D.; Wiltberger, M.; Raeder, J.; hide

    2016-01-01

    We present the latest result of a community-wide space weather model validation effort coordinated among the Community Coordinated Modeling Center (CCMC), NOAA Space Weather Prediction Center (SWPC), model developers, and the broader science community. Validation of geospace models is a critical activity for both building confidence in the science results produced by the models and in assessing the suitability of the models for transition to operations. Indeed, a primary motivation of this work is supporting NOAA/SWPCs effort to select a model or models to be transitioned into operations. Our validation efforts focus on the ability of the models to reproduce a regional index of geomagnetic disturbance, the local K-index. Our analysis includes six events representing a range of geomagnetic activity conditions and six geomagnetic observatories representing midlatitude and high-latitude locations. Contingency tables, skill scores, and distribution metrics are used for the quantitative analysis of model performance. We consider model performance on an event-by-event basis, aggregated over events, at specific station locations, and separated into high-latitude and midlatitude domains. A summary of results is presented in this report, and an online tool for detailed analysis is available at the CCMC.

  14. Current recommendations on the estimation of transition probabilities in Markov cohort models for use in health care decision-making: a targeted literature review.

    PubMed

    Olariu, Elena; Cadwell, Kevin K; Hancock, Elizabeth; Trueman, David; Chevrou-Severac, Helene

    2017-01-01

    Although Markov cohort models represent one of the most common forms of decision-analytic models used in health care decision-making, correct implementation of such models requires reliable estimation of transition probabilities. This study sought to identify consensus statements or guidelines that detail how such transition probability matrices should be estimated. A literature review was performed to identify relevant publications in the following databases: Medline, Embase, the Cochrane Library, and PubMed. Electronic searches were supplemented by manual-searches of health technology assessment (HTA) websites in Australia, Belgium, Canada, France, Germany, Ireland, Norway, Portugal, Sweden, and the UK. One reviewer assessed studies for eligibility. Of the 1,931 citations identified in the electronic searches, no studies met the inclusion criteria for full-text review, and no guidelines on transition probabilities in Markov models were identified. Manual-searching of the websites of HTA agencies identified ten guidelines on economic evaluations (Australia, Belgium, Canada, France, Germany, Ireland, Norway, Portugal, Sweden, and UK). All identified guidelines provided general guidance on how to develop economic models, but none provided guidance on the calculation of transition probabilities. One relevant publication was identified following review of the reference lists of HTA agency guidelines: the International Society for Pharmacoeconomics and Outcomes Research taskforce guidance. This provided limited guidance on the use of rates and probabilities. There is limited formal guidance available on the estimation of transition probabilities for use in decision-analytic models. Given the increasing importance of cost-effectiveness analysis in the decision-making processes of HTA bodies and other medical decision-makers, there is a need for additional guidance to inform a more consistent approach to decision-analytic modeling. Further research should be done to

  15. Modeling the Transitions between Collective and Solitary Migration Phenotypes in Cancer Metastasis

    PubMed Central

    Huang, Bin; Jolly, Mohit Kumar; Lu, Mingyang; Tsarfaty, Ilan; Ben-Jacob, Eshel; Onuchic, Jose’ N

    2015-01-01

    Cellular plasticity during cancer metastasis is a major clinical challenge. Two key cellular plasticity mechanisms —Epithelial-to-Mesenchymal Transition (EMT) and Mesenchymal-to-Amoeboid Transition (MAT) – have been carefully investigated individually, yet a comprehensive understanding of their interconnections remains elusive. Previously, we have modeled the dynamics of the core regulatory circuits for both EMT (miR-200/ZEB/miR-34/SNAIL) and MAT (Rac1/RhoA). We now extend our previous work to study the coupling between these two core circuits by considering the two microRNAs (miR-200 and miR-34) as external signals to the core MAT circuit. We show that this coupled circuit enables four different stable steady states (phenotypes) that correspond to hybrid epithelial/mesenchymal (E/M), mesenchymal (M), amoeboid (A) and hybrid amoeboid/mesenchymal (A/M) phenotypes. Our model recapitulates the metastasis-suppressing role of the microRNAs even in the presence of EMT-inducing signals like Hepatocyte Growth Factor (HGF). It also enables mapping the microRNA levels to the transitions among various cell migration phenotypes. Finally, it offers a mechanistic understanding for the observed phenotypic transitions among different cell migration phenotypes, specifically the Collective-to-Amoeboid Transition (CAT). PMID:26627083

  16. State-and-transition model archetypes: a global taxonomy of rangeland change

    USDA-ARS?s Scientific Manuscript database

    State and transition models (STMs) synthesize science-based and local knowledge to formally represent the dynamics of rangeland and other ecosystems. Mental models or concepts of ecosystem dynamics implicitly underlie all management decisions in rangelands and thus how people influence rangeland sus...

  17. Stereodynamic insight into the thermal history effects on poly(vinyl chloride) calorimetric sub-glass and glass transitions as a fragile glass model.

    PubMed

    Pin, Jean-Mathieu; Behazin, Ehsan; Misra, Manjusri; Mohanty, Amar

    2018-05-02

    The dynamic thermal history impact of poly(vinyl chloride) (PVC) has been explored for a wide range of pre-cooling rates, from 1 to 30 °C min-1. A first macroscopic insight into the dynamic thermal history influence has been highlighted through a decrease in the apparent activation energy (Eapp) in the first stage of the glass transition. The overall glass transition Eapp surface was successfully modeled in a polynomial fashion regarding the pre-cooling range. Raman scattering was used to associate the Eapp variations along the glass transition conversion with the stereochemistry evolution during the polymeric relaxation. Herein, the selection of atactic PVC as the polymer model permits us to monitor the glassy polymer segment stereodynamics during the heating ramp through the C-Cl stretching. The intermolecular H-Cl dipole interactions, as well as intramolecular conformational reorganizations among syndiotactic, isotactic and heterotactic polymer sequences, have been associated with non-cooperative and cooperative motions, i.e. the β- and α-process, respectively. The fruitful comparison of the two extreme values of the pre-cooling rates permits us to propose a thermokinetic scenario that explains the occurrence, intensity, and inter-dependence of β- and α-processes in the glassy state and during the glass transition. This scenario could potentially be generalized to all the other polymeric glass-formers.

  18. Electronic Relaxation Processes of Transition Metal Atoms in Helium Nanodroplets

    NASA Astrophysics Data System (ADS)

    Kautsch, Andreas; Lindebner, Friedrich; Koch, Markus; Ernst, Wolfgang E.

    2014-06-01

    Spectroscopy of doped superfluid helium nanodroplets (He_N) gives information about the influence of this cold, chemically inert, and least interacting matrix environment on the excitation and relaxation dynamics of dopant atoms and molecules. We present the results from laser induced fluorescence (LIF), photoionization (PI), and mass spectroscopy of Cr and Cu doped He_N. From these results, we can draw a comprehensive picture of the complex behavior of such transition metal atoms in He_N upon photo-excitation. The strong Cr and Cu ground state transitions show an excitation blueshift and broadening with respect to the bare atom transitions which can be taken as indication for the solvation inside the droplet. From the originally excited states the atoms relax to energetically lower states and are ejected from the He_N. The relaxation processes include bare atom spin-forbidden transitions, which clearly bears the signature of the He_N influence. Two-color resonant two-photon ionization (2CR2PI) also shows the formation of bare atoms and small Cr-He_n and Cu-He_n clusters in their ground and metastable states ^c. Currently, Cr dimer excitation studies are in progress and a brief outlook on the available results will be given. C. Callegari and W. E. Ernst, Helium Droplets as Nanocryostats for Molecular Spectroscopy - from the Vacuum Ultraviolet to the Microwave Regime, in Handbook of High-Resolution Spectroscopy, eds. M. Quack and F. Merkt, John Wiley & Sons, Chichester, 2011. A. Kautsch, M. Koch, and W. E. Ernst, J. Phys. Chem. A, 117 (2013) 9621-9625, DOI: 10.1021/jp312336m F. Lindebner, A. Kautsch, M. Koch, and W. E. Ernst, Int. J. Mass Spectrom. (2014) in press, DOI: 10.1016/j.ijms.2013.12.022 M. Koch, A. Kautsch, F. Lackner, and W. E. Ernst, submitted to J. Phys. Chem. A

  19. Transforming Collaborative Process Models into Interface Process Models by Applying an MDA Approach

    NASA Astrophysics Data System (ADS)

    Lazarte, Ivanna M.; Chiotti, Omar; Villarreal, Pablo D.

    Collaborative business models among enterprises require defining collaborative business processes. Enterprises implement B2B collaborations to execute these processes. In B2B collaborations the integration and interoperability of processes and systems of the enterprises are required to support the execution of collaborative processes. From a collaborative process model, which describes the global view of the enterprise interactions, each enterprise must define the interface process that represents the role it performs in the collaborative process in order to implement the process in a Business Process Management System. Hence, in this work we propose a method for the automatic generation of the interface process model of each enterprise from a collaborative process model. This method is based on a Model-Driven Architecture to transform collaborative process models into interface process models. By applying this method, interface processes are guaranteed to be interoperable and defined according to a collaborative process.

  20. Specificity in Transition State Binding: The Pauling Model Revisited

    PubMed Central

    Amyes, Tina L.; Richard, John P.

    2013-01-01

    Linus Pauling proposed that the large rate accelerations for enzymes are due to the high specificity of the protein catalyst for binding the reaction transition state. The observation that stable analogs of the transition states for enzymatic reactions often act as tight-binding binding inhibitors provided early support for this simple and elegant proposal. We review experimental results which support the proposal that Pauling’s model provides a satisfactory explanation for the rate accelerations for many heterolytic enzymatic reactions through high energy reaction intermediates, such as proton transfer and decarboxylation. Specificity in transition state binding is obtained when the total intrinsic binding energy of the substrate is significantly larger than the binding energy observed at the Michaelis complex. The results of recent studies to characterize the specificity in binding of the enolate oxygen at the transition state for the 1,3-isomerization reaction catalyzed by ketosteroid isomerase are reviewed. Interactions between pig heart succinyl-CoA:3-oxoacid coenzyme A transferase (SCOT) and the nonreacting portions of CoA are responsible for a rate increase of 3 × 1012-fold, which is close to the estimated total 5 × 1013-fold enzymatic rate acceleration. Studies that partition the interactions between SCOT and CoA into their contributing parts are reviewed. Interactions of the protein with the substrate phosphodianion group provide a ca. 12 kcal/mol stabilization of the transition state for the reactions catalyzed by triosephosphate isomerase, orotidine 5′-monophosphate decarboxylase and α-glycerol phosphate dehydrogenase. The interactions of these enzymes with the substrate piece phosphite dianion provide a 6 – 8 kcal/mol stabilization of the transition state for reaction of the appropriate truncated substrate. Enzyme activation by phosphite dianion reflects the higher dianion affinity for binding to the enzyme-transition state complex compared

  1. Major transitions in human evolution.

    PubMed

    Foley, Robert A; Martin, Lawrence; Mirazón Lahr, Marta; Stringer, Chris

    2016-07-05

    Evolutionary problems are often considered in terms of 'origins', and research in human evolution seen as a search for human origins. However, evolution, including human evolution, is a process of transitions from one state to another, and so questions are best put in terms of understanding the nature of those transitions. This paper discusses how the contributions to the themed issue 'Major transitions in human evolution' throw light on the pattern of change in hominin evolution. Four questions are addressed: (1) Is there a major divide between early (australopithecine) and later (Homo) evolution? (2) Does the pattern of change fit a model of short transformations, or gradual evolution? (3) Why is the role of Africa so prominent? (4) How are different aspects of adaptation-genes, phenotypes and behaviour-integrated across the transitions? The importance of developing technologies and approaches and the enduring role of fieldwork are emphasized.This article is part of the themed issue 'Major transitions in human evolution'. © 2016 The Author(s).

  2. Major transitions in human evolution

    PubMed Central

    Foley, Robert A.; Martin, Lawrence; Mirazón Lahr, Marta; Stringer, Chris

    2016-01-01

    Evolutionary problems are often considered in terms of ‘origins', and research in human evolution seen as a search for human origins. However, evolution, including human evolution, is a process of transitions from one state to another, and so questions are best put in terms of understanding the nature of those transitions. This paper discusses how the contributions to the themed issue ‘Major transitions in human evolution’ throw light on the pattern of change in hominin evolution. Four questions are addressed: (1) Is there a major divide between early (australopithecine) and later (Homo) evolution? (2) Does the pattern of change fit a model of short transformations, or gradual evolution? (3) Why is the role of Africa so prominent? (4) How are different aspects of adaptation—genes, phenotypes and behaviour—integrated across the transitions? The importance of developing technologies and approaches and the enduring role of fieldwork are emphasized. This article is part of the themed issue ‘Major transitions in human evolution’. PMID:27298461

  3. Multistage degradation modeling for BLDC motor based on Wiener process

    NASA Astrophysics Data System (ADS)

    Yuan, Qingyang; Li, Xiaogang; Gao, Yuankai

    2018-05-01

    Brushless DC motors are widely used, and their working temperatures, regarding as degradation processes, are nonlinear and multistage. It is necessary to establish a nonlinear degradation model. In this research, our study was based on accelerated degradation data of motors, which are their working temperatures. A multistage Wiener model was established by using the transition function to modify linear model. The normal weighted average filter (Gauss filter) was used to improve the results of estimation for the model parameters. Then, to maximize likelihood function for parameter estimation, we used numerical optimization method- the simplex method for cycle calculation. Finally, the modeling results show that the degradation mechanism changes during the degradation of the motor with high speed. The effectiveness and rationality of model are verified by comparison of the life distribution with widely used nonlinear Wiener model, as well as a comparison of QQ plots for residual. Finally, predictions for motor life are gained by life distributions in different times calculated by multistage model.

  4. A Latent Transition Analysis Model for Assessing Change in Cognitive Skills

    ERIC Educational Resources Information Center

    Li, Feiming; Cohen, Allan; Bottge, Brian; Templin, Jonathan

    2016-01-01

    Latent transition analysis (LTA) was initially developed to provide a means of measuring change in dynamic latent variables. In this article, we illustrate the use of a cognitive diagnostic model, the DINA model, as the measurement model in a LTA, thereby demonstrating a means of analyzing change in cognitive skills over time. An example is…

  5. Classical analysis of quantum phase transitions in a bilayer model.

    PubMed

    Figueiredo, Mariane Camargos; Cotta, Tathiana Moreira; Pellegrino, Giancarlo Queiroz

    2010-01-01

    In this Brief Report we extend the classical analysis performed on the schematic model proposed in [T. Moreira, G. Q. Pellegrino, J. G. Peixoto de Faria, M. C. Nemes, F. Camargo, and A. F. R. Toledo Piza, Phys. Rev. E 77, 051102 (2008)] concerning quantum phase transitions in a bilayer system. We show that appropriate integrations along the classical periodic orbits reproduce with excellent agreement both the quantum spectrum and the expected mean value for the number of excitons in the system, quantities which are directly related to the observed boson-fermion quantum phase transition.

  6. Dendrimersomes Exhibit Lamellar-to-Sponge Phase Transitions.

    PubMed

    Wilner, Samantha E; Xiao, Qi; Graber, Zachary T; Sherman, Samuel E; Percec, Virgil; Baumgart, Tobias

    2018-05-15

    Lamellar to nonlamellar membrane shape transitions play essential roles in key cellular processes, such as membrane fusion and fission, and occur in response to external stimuli, including drug treatment and heat. A subset of these transitions can be modeled by means of thermally inducible amphiphile assemblies. We previously reported on mixtures of hydrogenated, fluorinated, and hybrid Janus dendrimers (JDs) that self-assemble into complex dendrimersomes (DMSs), including dumbbells, and serve as promising models for understanding the complexity of biological membranes. Here we show, by means of a variety of complementary techniques, that DMSs formed by single JDs or by mixtures of JDs undergo a thermally induced lamellar-to-sponge transition. Consistent with the formation of a three-dimensional bilayer network, we show that DMSs become more permeable to water-soluble fluorophores after transitioning to the sponge phase. These DMSs may be useful not only in modeling isotropic membrane rearrangements of biological systems but also in drug delivery since nonlamellar delivery vehicles can promote endosomal disruption and cargo release.

  7. Transitioning Science and Technology into Acquisition Programs: Assessing One Government Laboratorys Processes

    DTIC Science & Technology

    2015-12-01

    Accountability Office reports and recommendations, and ARDEC and the program managers established processes. The research indicated that the...Record. This examination was a direct review and comparison of Department of Defense policies, U.S. Government Accountability Office reports and...Government Accountability Office I&TT Innovation and Technology Transition IPT Integrated Product Team JCIDS Joint Capabilities Integration

  8. Unifying Screening Processes Within the PROSPR Consortium: A Conceptual Model for Breast, Cervical, and Colorectal Cancer Screening

    PubMed Central

    Kim, Jane J.; Schapira, Marilyn M.; Tosteson, Anna N. A.; Zauber, Ann G.; Geiger, Ann M.; Kamineni, Aruna; Weaver, Donald L.; Tiro, Jasmin A.

    2015-01-01

    General frameworks of the cancer screening process are available, but none directly compare the process in detail across different organ sites. This limits the ability of medical and public health professionals to develop and evaluate coordinated screening programs that apply resources and population management strategies available for one cancer site to other sites. We present a trans-organ conceptual model that incorporates a single screening episode for breast, cervical, and colorectal cancers into a unified framework based on clinical guidelines and protocols; the model concepts could be expanded to other organ sites. The model covers four types of care in the screening process: risk assessment, detection, diagnosis, and treatment. Interfaces between different provider teams (eg, primary care and specialty care), including communication and transfer of responsibility, may occur when transitioning between types of care. Our model highlights across each organ site similarities and differences in steps, interfaces, and transitions in the screening process and documents the conclusion of a screening episode. This model was developed within the National Cancer Institute–funded consortium Population-based Research Optimizing Screening through Personalized Regimens (PROSPR). PROSPR aims to optimize the screening process for breast, cervical, and colorectal cancer and includes seven research centers and a statistical coordinating center. Given current health care reform initiatives in the United States, this conceptual model can facilitate the development of comprehensive quality metrics for cancer screening and promote trans-organ comparative cancer screening research. PROSPR findings will support the design of interventions that improve screening outcomes across multiple cancer sites. PMID:25957378

  9. Transition between 'base' and 'tip' carbon nanofiber growth modes

    NASA Astrophysics Data System (ADS)

    Melechko, Anatoli V.; Merkulov, Vladimir I.; Lowndes, Douglas H.; Guillorn, Michael A.; Simpson, Michael L.

    2002-04-01

    Carbon nanofibers (CNFs) have been synthesized by catalytically controlled dc glow discharge plasma-enhanced chemical vapor deposition (PECVD). Both base-type and tip-type nanofibers have been produced on identical substrates. We have observed a sharp transition between these two growth modes by controlling the kinetics of the growth process without changing the substrate and catalyst materials. This transition is brought about by changing the parameters used in the deposition process such as the flow ratio of the carbonaceous and etchant gasses and others. This study of the initial growth stages as a function of time for both regimes provides a basis for a model of the growth mode transition.

  10. Chapter 3: Simulating fire hazard across landscapes through time: integrating state-and-transition models with the Fuel Characteristic Classification System

    Treesearch

    Jessica E. Halofsky; Stephanie K. Hart; Miles A. Hemstrom; Joshua S. Halofsky; Morris C. Johnson

    2014-01-01

    Information on the effects of management activities such as fuel reduction treatments and of processes such as vegetation growth and disturbance on fire hazard can help land managers prioritize treatments across a landscape to best meet management goals. State-and-transition models (STMs) allow landscape-scale simulations that incorporate effects of succession,...

  11. Metal-insulator transition in a doubly orbitally degenerate model with correlated hopping

    NASA Astrophysics Data System (ADS)

    Didukh, L.; Skorenkyy, Yu.; Dovhopyaty, Yu.; Hankevych, V.

    2000-03-01

    In the present paper, we propose a doubly orbitally degenerate narrow-band model with correlated hopping. The peculiarity of the model is taking into account the matrix element of electron-electron interaction, which describes intersite hoppings of electrons. In particular, this leads to the concentration dependence of the effective hopping integral. The cases of the strong and weak Hund's coupling are considered. By means of a generalized mean-field approximation the single-particle Green function and quasiparticle energy spectrum are calculated. Metal-insulator transition is studied in the model at different integer values of the electron concentration. With the help of the obtained energy spectrum, we find energy gap width and criteria of metal-insulator transition.

  12. Velocity mode transition of dynamic crack propagation in hyperviscoelastic materials: A continuum model study.

    PubMed

    Kubo, Atsushi; Umeno, Yoshitaka

    2017-02-10

    Experiments of crack propagation in rubbers have shown that a discontinuous jump of crack propagation velocity can occur as energy release rate increases, which is known as the "mode transition" phenomenon. Although it is believed that the mode transition is strongly related to the mechanical properties, the nature of the mode transition had not been revealed. In this study, dynamic crack propagation on an elastomer was investigated using the finite element method (FEM) with a hyperviscoelastic material model. A series of pure shear test was carried out numerically with FEM simulations and crack velocities were measured under various values of tensile strain. As a result, our FEM simulations successfully reproduced the mode transition. The success of realising the mode transition phenomenon by a simple FEM model, which was achieved for the first time ever, helped to explain that the phenomenon occurs owing to a characteristic non-monotonic temporal development of principal stress near the crack tip.

  13. Phase transitions in community detection: A solvable toy model

    NASA Astrophysics Data System (ADS)

    Ver Steeg, Greg; Moore, Cristopher; Galstyan, Aram; Allahverdyan, Armen

    2014-05-01

    Recently, it was shown that there is a phase transition in the community detection problem. This transition was first computed using the cavity method, and has been proved rigorously in the case of q = 2 groups. However, analytic calculations using the cavity method are challenging since they require us to understand probability distributions of messages. We study analogous transitions in the so-called “zero-temperature inference” model, where this distribution is supported only on the most likely messages. Furthermore, whenever several messages are equally likely, we break the tie by choosing among them with equal probability, corresponding to an infinitesimal random external field. While the resulting analysis overestimates the thresholds, it reproduces some of the qualitative features of the system. It predicts a first-order detectability transition whenever q > 2 (as opposed to q > 4 according to the finite-temperature cavity method). It also has a regime analogous to the “hard but detectable” phase, where the community structure can be recovered, but only when the initial messages are sufficiently accurate. Finally, we study a semisupervised setting where we are given the correct labels for a fraction ρ of the nodes. For q > 2, we find a regime where the accuracy jumps discontinuously at a critical value of ρ.

  14. New insights into the transport processes controlling the sulfate-methane-transition-zone near methane vents.

    PubMed

    Sultan, Nabil; Garziglia, Sébastien; Ruffine, Livio

    2016-05-27

    Over the past years, several studies have raised concerns about the possible interactions between methane hydrate decomposition and external change. To carry out such an investigation, it is essential to characterize the baseline dynamics of gas hydrate systems related to natural geological and sedimentary processes. This is usually treated through the analysis of sulfate-reduction coupled to anaerobic oxidation of methane (AOM). Here, we model sulfate reduction coupled with AOM as a two-dimensional (2D) problem including, advective and diffusive transport. This is applied to a case study from a deep-water site off Nigeria's coast where lateral methane advection through turbidite layers was suspected. We show by analyzing the acquired data in combination with computational modeling that a two-dimensional approach is able to accurately describe the recent past dynamics of such a complex natural system. Our results show that the sulfate-methane-transition-zone (SMTZ) is not a vertical barrier for dissolved sulfate and methane. We also show that such a modeling is able to assess short timescale variations in the order of decades to centuries.

  15. Deflagration to Detonation Transition (DDT) Simulations of HMX Powder Using the HERMES Model

    NASA Astrophysics Data System (ADS)

    White, Bradley; Reaugh, John; Tringe, Joseph

    2017-06-01

    We performed computer simulations of DDT experiments with Class I HMX powder using the HERMES model (High Explosive Response to MEchanical Stimulus) in ALE3D. Parameters for the model were fitted to the limited available mechanical property data of the low-density powder, and to the Shock to Detonation Transition (SDT) test results. The DDT tests were carried out in steel-capped polycarbonate tubes. This arrangement permits direct observation of the event using both flash X-ray radiography and high speed camera imaging, and provides a stringent test of the model. We found the calculated detonation transition to be qualitatively similar to experiment. Through simulation we also explored the effects of confinement strength, the HMX particle size distribution and porosity on the computed detonation transition location. This work was performed under the auspices of the US DOE by LLNL under Contract DE-AC52-07NA27344.

  16. Modeling thermal inkjet and cell printing process using modified pseudopotential and thermal lattice Boltzmann methods.

    PubMed

    Sohrabi, Salman; Liu, Yaling

    2018-03-01

    Pseudopotential lattice Boltzmann methods (LBMs) can simulate a phase transition in high-density ratio multiphase flow systems. If coupled with thermal LBMs through equation of state, they can be used to study instantaneous phase transition phenomena with a high-temperature gradient where only one set of formulations in an LBM system can handle liquid, vapor, phase transition, and heat transport. However, at lower temperatures an unrealistic spurious current at the interface introduces instability and limits its application in real flow system. In this study, we proposed new modifications to the LBM system to minimize a spurious current which enables us to study nucleation dynamic at room temperature. To demonstrate the capabilities of this approach, the thermal ejection process is modeled as one example of a complex flow system. In an inkjet printer, a thermal pulse instantly heats up the liquid in a microfluidic chamber and nucleates bubble vapor providing the pressure pulse necessary to eject droplets at high speed. Our modified method can present a more realistic model of the explosive vaporization process since it can also capture a high-temperature/density gradient at nucleation region. Thermal inkjet technology has been successfully applied for printing cells, but cells are susceptible to mechanical damage or death as they squeeze out of the nozzle head. To study cell deformation, a spring network model, representing cells, is connected to the LBM through the immersed boundary method. Looking into strain and stress distribution of a cell membrane at its most deformed state, it is found that a high stretching rate effectively increases the rupture tension. In other words, membrane deformation energy is released through creation of multiple smaller nanopores rather than big pores. Overall, concurrently simulating multiphase flow, phase transition, heat transfer, and cell deformation in one unified LB platform, we are able to provide a better insight into the

  17. Modeling thermal inkjet and cell printing process using modified pseudopotential and thermal lattice Boltzmann methods

    NASA Astrophysics Data System (ADS)

    Sohrabi, Salman; Liu, Yaling

    2018-03-01

    Pseudopotential lattice Boltzmann methods (LBMs) can simulate a phase transition in high-density ratio multiphase flow systems. If coupled with thermal LBMs through equation of state, they can be used to study instantaneous phase transition phenomena with a high-temperature gradient where only one set of formulations in an LBM system can handle liquid, vapor, phase transition, and heat transport. However, at lower temperatures an unrealistic spurious current at the interface introduces instability and limits its application in real flow system. In this study, we proposed new modifications to the LBM system to minimize a spurious current which enables us to study nucleation dynamic at room temperature. To demonstrate the capabilities of this approach, the thermal ejection process is modeled as one example of a complex flow system. In an inkjet printer, a thermal pulse instantly heats up the liquid in a microfluidic chamber and nucleates bubble vapor providing the pressure pulse necessary to eject droplets at high speed. Our modified method can present a more realistic model of the explosive vaporization process since it can also capture a high-temperature/density gradient at nucleation region. Thermal inkjet technology has been successfully applied for printing cells, but cells are susceptible to mechanical damage or death as they squeeze out of the nozzle head. To study cell deformation, a spring network model, representing cells, is connected to the LBM through the immersed boundary method. Looking into strain and stress distribution of a cell membrane at its most deformed state, it is found that a high stretching rate effectively increases the rupture tension. In other words, membrane deformation energy is released through creation of multiple smaller nanopores rather than big pores. Overall, concurrently simulating multiphase flow, phase transition, heat transfer, and cell deformation in one unified LB platform, we are able to provide a better insight into the

  18. PyTranSpot: A tool for multiband light curve modeling of planetary transits and stellar spots

    NASA Astrophysics Data System (ADS)

    Juvan, Ines G.; Lendl, M.; Cubillos, P. E.; Fossati, L.; Tregloan-Reed, J.; Lammer, H.; Guenther, E. W.; Hanslmeier, A.

    2018-02-01

    Several studies have shown that stellar activity features, such as occulted and non-occulted starspots, can affect the measurement of transit parameters biasing studies of transit timing variations and transmission spectra. We present PyTranSpot, which we designed to model multiband transit light curves showing starspot anomalies, inferring both transit and spot parameters. The code follows a pixellation approach to model the star with its corresponding limb darkening, spots, and transiting planet on a two dimensional Cartesian coordinate grid. We combine PyTranSpot with a Markov chain Monte Carlo framework to study and derive exoplanet transmission spectra, which provides statistically robust values for the physical properties and uncertainties of a transiting star-planet system. We validate PyTranSpot's performance by analyzing eleven synthetic light curves of four different star-planet systems and 20 transit light curves of the well-studied WASP-41b system. We also investigate the impact of starspots on transit parameters and derive wavelength dependent transit depth values for WASP-41b covering a range of 6200-9200 Å, indicating a flat transmission spectrum.

  19. Observation and modeling of deflagration-to-detonation transition (DDT) in low-density HMX

    NASA Astrophysics Data System (ADS)

    Tringe, Joseph W.; Vandersall, Kevin S.; Reaugh, John E.; Levie, Harold W.; Henson, Bryan F.; Smilowitz, Laura B.; Parker, Gary R.

    2017-01-01

    We employ simultaneous flash x-ray radiography and streak imaging, together with a multi-phase finite element model, to understand deflagration-to-detonation transition (DDT) phenomena in low-density (˜1.2 gm/cm3) powder of the explosive cyclotetramethylene-tetranitramine (HMX). HMX powder was lightly hand-tamped in a 12.7 mm diameter column, relatively lightly-confined in an optically-transparent polycarbonate cylinder with wall thickness 25.4 mm. We observe apparent compaction of the powder in advance of the detonation transition by the motion of small steel spheres pre-emplaced throughout the length of explosive. High-speed imaging along the explosive cylinder length provides a more temporally continuous record of the transition that is correlated with the high-resolution x-ray image record. Preliminary simulation of these experiments with the HERMES model implemented in the ALE3D code enables improved understanding of the explosive particle burning, compaction and detonation phenomena which are implied by the observed reaction rate and transition location within the cylinder.

  20. A 1D thermomechanical network transition constitutive model coupled with multiple structural relaxation for shape memory polymers

    NASA Astrophysics Data System (ADS)

    Zeng, Hao; Xie, Zhimin; Gu, Jianping; Sun, Huiyu

    2018-03-01

    A new thermomechanical network transition constitutive model is proposed in the study to describe the viscoelastic behavior of shape memory polymers (SMPs). Based on the microstructure of semi-crystalline SMPs, a new simplified transformation equation is proposed to describe the transform of transient networks. And the generalized fractional Maxwell model is introduced in the paper to estimate the temperature-dependent storage modulus. In addition, a neo-KAHR theory with multiple discrete relaxation processes is put forward to study the structural relaxation of the nonlinear thermal strain in cooling/heating processes. The evolution equations of the time- and temperature-dependent stress and strain response are developed. In the model, the thermodynamical and mechanical characteristics of SMPs in the typical thermomechanical cycle are described clearly and the irreversible deformation is studied in detail. Finally, the typical thermomechanical cycles are simulated using the present constitutive model, and the simulation results agree well with the experimental results.

  1. Modeling Pedagogy for Teachers Transitioning to the Virtual Classroom

    ERIC Educational Resources Information Center

    Canuel, Michael J.; White, Beverley J.

    2014-01-01

    This study is a review of the creation and evolution of a professional development program modeled on social constructivist principles and designed for online educators in a virtual high school who transitioned from the conventional classroom to the virtual educational environment. The narrative inquiry focuses on the critical events within the…

  2. Examining hydrogen transitions.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Plotkin, S. E.; Energy Systems

    2007-03-01

    This report describes the results of an effort to identify key analytic issues associated with modeling a transition to hydrogen as a fuel for light duty vehicles, and using insights gained from this effort to suggest ways to improve ongoing modeling efforts. The study reported on here examined multiple hydrogen scenarios reported in the literature, identified modeling issues associated with those scenario analyses, and examined three DOE-sponsored hydrogen transition models in the context of those modeling issues. The three hydrogen transition models are HyTrans (contractor: Oak Ridge National Laboratory), MARKAL/DOE* (Brookhaven National Laboratory), and NEMS-H2 (OnLocation, Inc). The goals ofmore » these models are (1) to help DOE improve its R&D effort by identifying key technology and other roadblocks to a transition and testing its technical program goals to determine whether they are likely to lead to the market success of hydrogen technologies, (2) to evaluate alternative policies to promote a transition, and (3) to estimate the costs and benefits of alternative pathways to hydrogen development.« less

  3. Processed foods and the nutrition transition: evidence from Asia.

    PubMed

    Baker, P; Friel, S

    2014-07-01

    This paper elucidates the role of processed foods and beverages in the 'nutrition transition' underway in Asia. Processed foods tend to be high in nutrients associated with obesity and diet-related non-communicable diseases: refined sugar, salt, saturated and trans-fats. This paper identifies the most significant 'product vectors' for these nutrients and describes changes in their consumption in a selection of Asian countries. Sugar, salt and fat consumption from processed foods has plateaued in high-income countries, but has rapidly increased in the lower-middle and upper-middle-income countries. Relative to sugar and salt, fat consumption in the upper-middle- and lower-middle-income countries is converging most rapidly with that of high-income countries. Carbonated soft drinks, baked goods, and oils and fats are the most significant vectors for sugar, salt and fat respectively. At the regional level there appears to be convergence in consumption patterns of processed foods, but country-level divergences including high levels of consumption of oils and fats in Malaysia, and soft drinks in the Philippines and Thailand. This analysis suggests that more action is needed by policy-makers to prevent or mitigate processed food consumption. Comprehensive policy and regulatory approaches are most likely to be effective in achieving these goals. © 2014 The Authors. obesity reviews © 2014 World Obesity.

  4. Transitioning to a High-Value Health Care Model: Academic Accountability.

    PubMed

    Johnson, Pamela T; Alvin, Matthew D; Ziegelstein, Roy C

    2018-06-01

    Health care spending in the United States has increased to unprecedented levels, and these costs have broken medical providers' promise to do no harm. Medical debt is the leading contributor to U.S. personal bankruptcy, more than 50% of household foreclosures are secondary to medical debt and illness, and patients are choosing to avoid necessary care because of its cost. Evidence that the health care delivery model is contributing to patient hardship is a call to action for the profession to transition to a high-value model, one that delivers the highest health care quality and safety at the lowest personal and financial cost to patients. As such, value improvement work is being done at academic medical centers across the country. To promote measurable improvements in practice on a national scale, academic institutions need to align efforts and create a new model for collaboration, one that transcends cross-institutional competition, specialty divisions, and geographical constraints. Academic institutions are particularly accountable because of the importance of research and education in driving this transition. Investigations that elucidate effective implementation methodologies and evaluate safety outcomes data can facilitate transformation. Engaging trainees in quality improvement initiatives will instill high-value care into their practice. This article charges academic institutions to go beyond dissemination of best practice guidelines and demonstrate accountability for high-value quality improvement implementation. By effectively transitioning to a high-value health care system, medical providers will convincingly demonstrate that patients are their most important priority.

  5. Field signatures of non-Fickian transport processes: transit time distributions, spatial correlations, reversibility and hydrogeophysical imaging

    NASA Astrophysics Data System (ADS)

    Le Borgne, T.; Kang, P. K.; Guihéneuf, N.; Shakas, A.; Bour, O.; Linde, N.; Dentz, M.

    2015-12-01

    Non-Fickian transport phenomena are observed in a wide range of scales across hydrological systems. They are generally manifested by a broad range of transit time distributions, as measured for instance in tracer breakthrough curves. However, similar transit time distributions may be caused by different origins, including broad velocity distributions, flow channeling or diffusive mass transfer [1,2]. The identification of these processes is critical for defining relevant transport models. How can we distinguish the different origins of non-Fickian transport in the field? In this presentation, we will review recent experimental developments to decipher the different causes of anomalous transport, based on tracer tests performed at different scales in cross borehole and push pull conditions, and time lapse hydrogeophysical imaging of tracer motion [3,4]. References:[1] de Anna-, P., T. Le Borgne, M. Dentz, A. M. Tartakovsky, D. Bolster, P. Davy (2013) Flow Intermittency, Dispersion and Correlated Continuous Time Random Walks in Porous Media, Phys. Rev. Lett., 110, 184502 [2] Le Borgne T., Dentz M., and Carrera J. (2008) Lagrangian Statistical Model for Transport in Highly Heterogeneous Velocity Fields. Phys. Rev. Lett. 101, 090601 [3] Kang, P. K., T. Le Borgne, M. Dentz, O. Bour, and R. Juanes (2015), Impact of velocity correlation and distribution on transport in fractured media : Field evidence and theoretical model, Water Resour. Res., 51, 940-959 [4] Dorn C., Linde N., Le Borgne T., O. Bour and L. Baron (2011) Single-hole GPR reflection imaging of solute transport in a granitic aquifer Geophys. Res. Lett. Vol.38, L08401

  6. Transition from AdS universe to DS universe in the BPP model

    NASA Astrophysics Data System (ADS)

    Kim, Wontae; Yoon, Myungseok

    2007-04-01

    It can be shown that in the BPP model the smooth phase transition from the asymptotically decelerated AdS universe to the asymptotically accelerated DS universe is possible by solving the modified semiclassical equations of motion. This transition comes from noncommutative Poisson algebra, which gives the constant curvature scalars asymptotically. The decelerated expansion of the early universe is due to the negative energy density with the negative pressure induced by quantum back reaction, and the accelerated late-time universe comes from the positive energy and the negative pressure which behave like dark energy source in recent cosmological models.

  7. Model of a programmable quantum processing unit based on a quantum transistor effect

    NASA Astrophysics Data System (ADS)

    Ablayev, Farid; Andrianov, Sergey; Fetisov, Danila; Moiseev, Sergey; Terentyev, Alexandr; Urmanchev, Andrey; Vasiliev, Alexander

    2018-02-01

    In this paper we propose a model of a programmable quantum processing device realizable with existing nano-photonic technologies. It can be viewed as a basis for new high performance hardware architectures. Protocols for physical implementation of device on the controlled photon transfer and atomic transitions are presented. These protocols are designed for executing basic single-qubit and multi-qubit gates forming a universal set. We analyze the possible operation of this quantum computer scheme. Then we formalize the physical architecture by a mathematical model of a Quantum Processing Unit (QPU), which we use as a basis for the Quantum Programming Framework. This framework makes it possible to perform universal quantum computations in a multitasking environment.

  8. Internally- and externally-driven network transitions as a basis for automatic and strategic processes in semantic priming: theory and experimental validation

    PubMed Central

    Lerner, Itamar; Shriki, Oren

    2014-01-01

    For the last four decades, semantic priming—the facilitation in recognition of a target word when it follows the presentation of a semantically related prime word—has been a central topic in research of human cognitive processing. Studies have drawn a complex picture of findings which demonstrated the sensitivity of this priming effect to a unique combination of variables, including, but not limited to, the type of relatedness between primes and targets, the prime-target Stimulus Onset Asynchrony (SOA), the relatedness proportion (RP) in the stimuli list and the specific task subjects are required to perform. Automatic processes depending on the activation patterns of semantic representations in memory and controlled strategies adapted by individuals when attempting to maximize their recognition performance have both been implicated in contributing to the results. Lately, we have published a new model of semantic priming that addresses the majority of these findings within one conceptual framework. In our model, semantic memory is depicted as an attractor neural network in which stochastic transitions from one stored pattern to another are continually taking place due to synaptic depression mechanisms. We have shown how such transitions, in combination with a reinforcement-learning rule that adjusts their pace, resemble the classic automatic and controlled processes involved in semantic priming and account for a great number of the findings in the literature. Here, we review the core findings of our model and present new simulations that show how similar principles of parameter-adjustments could account for additional data not addressed in our previous studies, such as the relation between expectancy and inhibition in priming, target frequency and target degradation effects. Finally, we describe two human experiments that validate several key predictions of the model. PMID:24795670

  9. Transitioning the Rice Realtime Forecast Models to DSCOVR

    NASA Astrophysics Data System (ADS)

    Bala, R.; Reiff, P. H.

    2016-12-01

    The Rice realtime forecast models of global magnetospheric indices Kp, Dst and AE have been actively running at mms.rice.edu/realtime/forecast.html for nearly a decade now. These neural network models were trained using the ACE archival solar wind data while the near-realtime forecasts are provided using instantaneous upwind solar wind data stream measured at the L1 point through ACE. Additionally, the webpage also provide status of the current space weather condition as an additional resource, updating every ten minutes. Furthermore, the subscribers of our space weather alert system, called `spacalrt', have been receiving email notices based on predefined thresholds. One of the gaps that is currently seen in the Rice neural network models lies in the density dependent models using variants of the solar wind pressure. The anomalous behavior in reporting densities in ACE has been a common issue for some time now. Often such behavior is observed when the solar energetic particle that are associated with solar flares or CMEs are Earth directed. Therefore, it is understood that the subsequent measures of the density reported by ACE will be either very low or, at a minimum, contaminated. Under these circumstances, the density-based Rice models typically underpredict. However, the newly launched DSCOVR satellite will help enhance our prediction models with high-quality data; it has real time space weather data available through the NOAA's Space Weather Prediction Center as of July, 2016. We are in the process of transitioning our forecast operations to include data from DSCOVR while running the original ACE data stream in parallel until it lasts. This paper will compare and contrast the forecasted values from the two satellites. Finally, we will discuss our efforts in providing the forecast products for the Rice space weather website that will be a part of the book on "Machine Learning Techniques for Space Weather" to be published by Elsiever.

  10. Constraints on active region coronal heating properties from observations and modeling of chromospheric, transition region, and coronal emission

    NASA Astrophysics Data System (ADS)

    Testa, P.; Polito, V.; De Pontieu, B.; Carlsson, M.; Reale, F.; Allred, J. C.; Hansteen, V. H.

    2017-12-01

    We investigate coronal heating properties in active region cores in non-flaring conditions, using high spatial, spectral, and temporal resolution chromospheric/transition region/coronal observations coupled with detailed modeling. We will focus, in particular, on observations with the Interface Region Imaging Spectrograph (IRIS), joint with observations with Hinode (XRT and EIS) and SDO/AIA. We will discuss how these observations and models (1D HD and 3D MHD, with the RADYN and Bifrost codes) provide useful diagnostics of the coronal heating processes and mechanisms of energy transport.

  11. A Dry-Etch Process for Low Temperature Superconducting Transition Edge Sensors for Far Infrared Bolometer Arrays

    NASA Technical Reports Server (NTRS)

    Allen, Christine A.; Chervenak, James A.; Hsieh, Wen-Ting; McClanahan, Richard A.; Miller, Timothy M.; Mitchell, Robert; Moseley, S. Harvey; Staguhn, Johannes; Stevenson, Thomas R.

    2003-01-01

    The next generation of ultra-low power bolometer arrays, with applications in far infrared imaging, spectroscopy and polarimetry, utilizes a superconducting bilayer as the sensing element to enable SQUID multiplexed readout. Superconducting transition edge sensors (TES s) are being produced with dual metal systems of superconductinghormal bilayers. The transition temperature (Tc) is tuned by altering the relative thickness of the superconductor with respect to the normal layer. We are currently investigating MoAu and MoCu bilayers. We have developed a dry-etching process for MoAu TES s with integrated molybdenum leads, and are working on adapting the process to MoCu. Dry etching has the advantage over wet etching in the MoAu system in that one can achieve a high degree of selectivity, greater than 10, using argon ME, or argon ion milling, for patterning gold on molybdenum. Molybdenum leads are subsequently patterned using fluorine plasma.. The dry-etch technique results in a smooth, featureless TES with sharp sidewalls, no undercutting of the Mo beneath the normal metal, and Mo leads with high critical current. The effects of individual processing parameters on the characteristics of the transition will be reported.

  12. Specificity in transition state binding: the Pauling model revisited.

    PubMed

    Amyes, Tina L; Richard, John P

    2013-03-26

    Linus Pauling proposed that the large rate accelerations for enzymes are caused by the high specificity of the protein catalyst for binding the reaction transition state. The observation that stable analogues of the transition states for enzymatic reactions often act as tight-binding inhibitors provided early support for this simple and elegant proposal. We review experimental results that support the proposal that Pauling's model provides a satisfactory explanation for the rate accelerations for many heterolytic enzymatic reactions through high-energy reaction intermediates, such as proton transfer and decarboxylation. Specificity in transition state binding is obtained when the total intrinsic binding energy of the substrate is significantly larger than the binding energy observed at the Michaelis complex. The results of recent studies that aimed to characterize the specificity in binding of the enolate oxygen at the transition state for the 1,3-isomerization reaction catalyzed by ketosteroid isomerase are reviewed. Interactions between pig heart succinyl-coenzyme A:3-oxoacid coenzyme A transferase (SCOT) and the nonreacting portions of coenzyme A (CoA) are responsible for a rate increase of 3 × 10(12)-fold, which is close to the estimated total 5 × 10(13)-fold enzymatic rate acceleration. Studies that partition the interactions between SCOT and CoA into their contributing parts are reviewed. Interactions of the protein with the substrate phosphodianion group provide an ~12 kcal/mol stabilization of the transition state for the reactions catalyzed by triosephosphate isomerase, orotidine 5'-monophosphate decarboxylase, and α-glycerol phosphate dehydrogenase. The interactions of these enzymes with the substrate piece phosphite dianion provide a 6-8 kcal/mol stabilization of the transition state for reaction of the appropriate truncated substrate. Enzyme activation by phosphite dianion reflects the higher dianion affinity for binding to the enzyme-transition

  13. Cooperative structural transitions in amyloid-like aggregation

    NASA Astrophysics Data System (ADS)

    Steckmann, Timothy; Bhandari, Yuba R.; Chapagain, Prem P.; Gerstman, Bernard S.

    2017-04-01

    Amyloid fibril aggregation is associated with several horrific diseases such as Alzheimer's, Creutzfeld-Jacob, diabetes, Parkinson's, and others. Although proteins that undergo aggregation vary widely in their primary structure, they all produce a cross-β motif with the proteins in β-strand conformations perpendicular to the fibril axis. The process of amyloid aggregation involves forming myriad different metastable intermediate aggregates. To better understand the molecular basis of the protein structural transitions and aggregation, we report on molecular dynamics (MD) computational studies on the formation of amyloid protofibrillar structures in the small model protein ccβ, which undergoes many of the structural transitions of the larger, naturally occurring amyloid forming proteins. Two different structural transition processes involving hydrogen bonds are observed for aggregation into fibrils: the breaking of intrachain hydrogen bonds to allow β-hairpin proteins to straighten, and the subsequent formation of interchain H-bonds during aggregation into amyloid fibrils. For our MD simulations, we found that the temperature dependence of these two different structural transition processes results in the existence of a temperature window that the ccβ protein experiences during the process of forming protofibrillar structures. This temperature dependence allows us to investigate the dynamics on a molecular level. We report on the thermodynamics and cooperativity of the transformations. The structural transitions that occurred in a specific temperature window for ccβ in our investigations may also occur in other amyloid forming proteins but with biochemical parameters controlling the dynamics rather than temperature.

  14. Markov Transition Model to Dementia with Death as a Competing Event.

    PubMed

    Wei, Shaoceng; Xu, Liou; Kryscio, Richard J

    2014-12-01

    This study evaluates the effect of death as a competing event to the development of dementia in a longitudinal study of the cognitive status of elderly subjects. A multi-state Markov model with three transient states: intact cognition, mild cognitive impairment (M.C.I.) and global impairment (G.I.) and one absorbing state: dementia is used to model the cognitive panel data; transitions among states depend on four covariates age, education, prior state (intact cognition, or M.C.I., or G.I.) and the presence/absence of an apolipoprotein E-4 allele (APOE4). A Weibull model and a Cox proportional hazards (Cox PH) model are used to fit the survival from death based on age at entry and the APOE4 status. A shared random effect correlates this survival time with the transition model. Simulation studies determine the sensitivity of the maximum likelihood estimates to the violations of the Weibull and Cox PH model assumptions. Results are illustrated with an application to the Nun Study, a longitudinal cohort of 672 participants 75+ years of age at baseline and followed longitudinally with up to ten cognitive assessments per nun.

  15. Markov Transition Model to Dementia with Death as a Competing Event

    PubMed Central

    Wei, Shaoceng; Xu, Liou; Kryscio, Richard J.

    2014-01-01

    This study evaluates the effect of death as a competing event to the development of dementia in a longitudinal study of the cognitive status of elderly subjects. A multi-state Markov model with three transient states: intact cognition, mild cognitive impairment (M.C.I.) and global impairment (G.I.) and one absorbing state: dementia is used to model the cognitive panel data; transitions among states depend on four covariates age, education, prior state (intact cognition, or M.C.I., or G.I.) and the presence/absence of an apolipoprotein E-4 allele (APOE4). A Weibull model and a Cox proportional hazards (Cox PH) model are used to fit the survival from death based on age at entry and the APOE4 status. A shared random effect correlates this survival time with the transition model. Simulation studies determine the sensitivity of the maximum likelihood estimates to the violations of the Weibull and Cox PH model assumptions. Results are illustrated with an application to the Nun Study, a longitudinal cohort of 672 participants 75+ years of age at baseline and followed longitudinally with up to ten cognitive assessments per nun. PMID:25110380

  16. From magma-poor Ocean Continent Transitions to steady state oceanic spreading: the balance between tectonic and magmatic processes

    NASA Astrophysics Data System (ADS)

    Gillard, Morgane; Manatschal, Gianreto; Autin, Julia; Decarlis, Alessandro; Sauter, Daniel

    2016-04-01

    The evolution of magma-poor rifted margins is linked to the development of a transition zone whose basement is neither clearly continental nor oceanic. The development of this Ocean-Continent Transition (OCT) is generally associated to the exhumation of serpentinized mantle along one or several detachment faults. That model is supported by numerous observations (IODP wells, dredges, fossil margins) and by numerical modelling. However, if the initiation of detachment faults in a magma-poor setting tends to be better understood by numerous studies in various area, the transition with the first steady state oceanic crust and the associated processes remain enigmatic and poorly studied. Indeed, this latest stage of evolution appears to be extremely gradual and involves strong interactions between tectonic processes and magmatism. Contrary to the proximal part of the exhumed domain where we can observe magmatic activity linked to the exhumation process (exhumation of gabbros, small amount of basalts above the exhumed mantle), in the most distal part the magmatic system appears to be independent and more active. In particular, we can observe large amounts of extrusive material above a previously exhumed and faulted basement (e.g. Alps, Australia-Antarctica margins). It seems that some faults can play the role of feeder systems for the magma in this area. Magmatic underplating is also important, as suggested by basement uplift and anomalously thick crust (e.g. East Indian margin). It results that the transition with the first steady state oceanic crust is marked by the presence of a hybrid basement, composed by exhumed mantle and magmatic material, whose formation is linked to several tectonic and magmatic events. One could argue that this basement is not clearly different from an oceanic basement. However, we consider that true, steady state oceanic crust only exists, if the entire rock association forming the crust is created during a single event, at a localized

  17. Survival modeling for the estimation of transition probabilities in model-based economic evaluations in the absence of individual patient data: a tutorial.

    PubMed

    Diaby, Vakaramoko; Adunlin, Georges; Montero, Alberto J

    2014-02-01

    Survival modeling techniques are increasingly being used as part of decision modeling for health economic evaluations. As many models are available, it is imperative for interested readers to know about the steps in selecting and using the most suitable ones. The objective of this paper is to propose a tutorial for the application of appropriate survival modeling techniques to estimate transition probabilities, for use in model-based economic evaluations, in the absence of individual patient data (IPD). An illustration of the use of the tutorial is provided based on the final progression-free survival (PFS) analysis of the BOLERO-2 trial in metastatic breast cancer (mBC). An algorithm was adopted from Guyot and colleagues, and was then run in the statistical package R to reconstruct IPD, based on the final PFS analysis of the BOLERO-2 trial. It should be emphasized that the reconstructed IPD represent an approximation of the original data. Afterwards, we fitted parametric models to the reconstructed IPD in the statistical package Stata. Both statistical and graphical tests were conducted to verify the relative and absolute validity of the findings. Finally, the equations for transition probabilities were derived using the general equation for transition probabilities used in model-based economic evaluations, and the parameters were estimated from fitted distributions. The results of the application of the tutorial suggest that the log-logistic model best fits the reconstructed data from the latest published Kaplan-Meier (KM) curves of the BOLERO-2 trial. Results from the regression analyses were confirmed graphically. An equation for transition probabilities was obtained for each arm of the BOLERO-2 trial. In this paper, a tutorial was proposed and used to estimate the transition probabilities for model-based economic evaluation, based on the results of the final PFS analysis of the BOLERO-2 trial in mBC. The results of our study can serve as a basis for any model

  18. Phase Transitions in Geomorphology

    NASA Astrophysics Data System (ADS)

    Ortiz, C. P.; Jerolmack, D. J.

    2015-12-01

    Landscapes are patterns in a dynamic steady-state, due to competing processes that smooth or sharpen features over large distances and times. Geomorphic transport laws have been developed to model the mass-flux due to different processes, but are unreasonably effective at recovering the scaling relations of landscape features. Using a continuum approximation to compare experimental landscapes and the observed landscapes of the earth, one finds they share similar morphodynamics despite a breakdown of classical dynamical similarity between the two. We propose the origin of this effectiveness is a different kind of dynamic similarity in the statistics of initiation and cessation of motion of groups of grains, which is common to disordered systems of grains under external driving. We will show how the existing data of sediment transport points to common signatures with dynamical phase transitions between "mobile" and "immobile" phases in other disordered systems, particularly granular materials, colloids, and foams. Viewing landscape evolution from the lens of non-equilibrium statistical physics of disordered systems leads to predictions that the transition of bulk measurements such as particle flux is continuous from one phase to another, that the collective nature of the particle dynamics leads to very slow aging of bulk properties, and that the dynamics are history-dependent. Recent results from sediment transport experiments support these predictions, suggesting that existing geomorphic transport laws may need to be replaced by a new generation of stochastic models with ingredients based on the physics of disordered phase transitions. We discuss possible strategies for extracting the necessary information to develop these models from measurements of geomorphic transport noise by connecting particle-scale collective dynamics and space-time fluctuations over landscape features.

  19. A geometrically controlled rigidity transition in a model for confluent 3D tissues

    NASA Astrophysics Data System (ADS)

    Merkel, Matthias; Manning, M. Lisa

    2018-02-01

    The origin of rigidity in disordered materials is an outstanding open problem in statistical physics. Previously, a class of 2D cellular models has been shown to undergo a rigidity transition controlled by a mechanical parameter that specifies cell shapes. Here, we generalize this model to 3D and find a rigidity transition that is similarly controlled by the preferred surface area S 0: the model is solid-like below a dimensionless surface area of {s}0\\equiv {S}0/{\\bar{V}}2/3≈ 5.413 with \\bar{V} being the average cell volume, and fluid-like above this value. We demonstrate that, unlike jamming in soft spheres, residual stresses are necessary to create rigidity. These stresses occur precisely when cells are unable to obtain their desired geometry, and we conjecture that there is a well-defined minimal surface area possible for disordered cellular structures. We show that the behavior of this minimal surface induces a linear scaling of the shear modulus with the control parameter at the transition point, which is different from the scaling observed in particulate matter. The existence of such a minimal surface may be relevant for biological tissues and foams, and helps explain why cell shapes are a good structural order parameter for rigidity transitions in biological tissues.

  20. Elastic Model Transitions: a Hybrid Approach Utilizing Quadratic Inequality Constrained Least Squares (LSQI) and Direct Shape Mapping (DSM)

    NASA Technical Reports Server (NTRS)

    Jurenko, Robert J.; Bush, T. Jason; Ottander, John A.

    2014-01-01

    A method for transitioning linear time invariant (LTI) models in time varying simulation is proposed that utilizes both quadratically constrained least squares (LSQI) and Direct Shape Mapping (DSM) algorithms to determine physical displacements. This approach is applicable to the simulation of the elastic behavior of launch vehicles and other structures that utilize multiple LTI finite element model (FEM) derived mode sets that are propagated throughout time. The time invariant nature of the elastic data for discrete segments of the launch vehicle trajectory presents a problem of how to properly transition between models while preserving motion across the transition. In addition, energy may vary between flex models when using a truncated mode set. The LSQI-DSM algorithm can accommodate significant changes in energy between FEM models and carries elastic motion across FEM model transitions. Compared with previous approaches, the LSQI-DSM algorithm shows improvements ranging from a significant reduction to a complete removal of transients across FEM model transitions as well as maintaining elastic motion from the prior state.

  1. Estimation of Catchment Transit Time in Fuji River Basin by using an improved Tank model

    NASA Astrophysics Data System (ADS)

    Wenchao, M.; Yamanaka, T.; Wakiyama, Y.; Wang, P.

    2013-12-01

    As an important parameter that reflects the characteristics of catchments, the catchment transit time (CTT) has been given much more widely attentions especially in recent years. The CTT is defined as the time water spends travelling through a catchment to the stream network [1], and it describes how catchments retain and release water and solutes and thus control geochemical and biogeochemical cycling and contamination persistence [2]. The objectives of the present study are to develop a new approach for estimating CTT without prior information on such TTD functions and to apply it to the Fuji River basin in the Central Japan Alps Region. In this study, an improved Tank model was used to compute mean CTT and TTD functions simultaneously. It involved water fluxes and isotope mass balance. Water storage capacity in the catchment, which strongly affects CTT, is reflected in isotope mass balance more sensitively than in water fluxes. A model calibrated with observed discharge and isotope data is used for virtual age tracer computation to estimate CTT. This model does not only consider the hydrological data and physical process of the research area but also reflects the actual TTD with considering the geological condition, land use and the other catchment-hydrological conditions. For the calibration of the model, we used river discharge record obtained by the Ministry of Land, Infrastructure and Transportation, and are collecting isotope data of precipitation and river waters monthly or semi-weekly. Three sub-catchments (SC1~SC3) in the Fuji River basin was selected to test the model with five layers: the surface layer, upper-soil layer, lower-soil layer, groundwater aquifer layer and bedrock layer (Layer 1- Layer 5). The evaluation of the model output was assessed using Nash-Sutcliffe efficiency (NSE), root mean square error-observations standard deviation ratio (RSR), and percent bias (PBIAS). Using long time-series of discharge records for calibration, the simulated

  2. Treatment of Electronic Energy Level Transition and Ionization Following the Particle-Based Chemistry Model

    NASA Technical Reports Server (NTRS)

    Liechty, Derek S.; Lewis, Mark

    2010-01-01

    A new method of treating electronic energy level transitions as well as linking ionization to electronic energy levels is proposed following the particle-based chemistry model of Bird. Although the use of electronic energy levels and ionization reactions in DSMC are not new ideas, the current method of selecting what level to transition to, how to reproduce transition rates, and the linking of the electronic energy levels to ionization are, to the author s knowledge, novel concepts. The resulting equilibrium temperatures are shown to remain constant, and the electronic energy level distributions are shown to reproduce the Boltzmann distribution. The electronic energy level transition rates and ionization rates due to electron impacts are shown to reproduce theoretical and measured rates. The rates due to heavy particle impacts, while not as favorable as the electron impact rates, compare favorably to values from the literature. Thus, these new extensions to the particle-based chemistry model of Bird provide an accurate method for predicting electronic energy level transition and ionization rates in gases.

  3. Drug abuse: vulnerability and transition to addiction.

    PubMed

    Le Moal, M

    2009-05-01

    Intrinsic vulnerability is central to the transition of recreational drug use to misuse. Several factors contribute to vulnerability, inherent or acquired, and they account for the huge individual differences observed concerning the propensity to enter in the addiction process. Some of the multifactional causes for a vulnerable phenotype will be examined: genetic factors, age and gender influences, various comorbidities and epidemiological observations. Stress-induced vulnerability will be particularly reviewed because it provides a good model for a pathophysiological research and for relating environmental events to biological consequences of drug vulnerability, namely through the striato-cortical dopamine system. Experimental studies are generally blind concerning these historical factors that contribute vulnerability and a critical evaluation of current animal models is needed. The transition of the last stage of the process, addiction, is conceptualized as a progression from homeostasis to allostasis and then, to pathology.

  4. Unifying screening processes within the PROSPR consortium: a conceptual model for breast, cervical, and colorectal cancer screening.

    PubMed

    Beaber, Elisabeth F; Kim, Jane J; Schapira, Marilyn M; Tosteson, Anna N A; Zauber, Ann G; Geiger, Ann M; Kamineni, Aruna; Weaver, Donald L; Tiro, Jasmin A

    2015-06-01

    General frameworks of the cancer screening process are available, but none directly compare the process in detail across different organ sites. This limits the ability of medical and public health professionals to develop and evaluate coordinated screening programs that apply resources and population management strategies available for one cancer site to other sites. We present a trans-organ conceptual model that incorporates a single screening episode for breast, cervical, and colorectal cancers into a unified framework based on clinical guidelines and protocols; the model concepts could be expanded to other organ sites. The model covers four types of care in the screening process: risk assessment, detection, diagnosis, and treatment. Interfaces between different provider teams (eg, primary care and specialty care), including communication and transfer of responsibility, may occur when transitioning between types of care. Our model highlights across each organ site similarities and differences in steps, interfaces, and transitions in the screening process and documents the conclusion of a screening episode. This model was developed within the National Cancer Institute-funded consortium Population-based Research Optimizing Screening through Personalized Regimens (PROSPR). PROSPR aims to optimize the screening process for breast, cervical, and colorectal cancer and includes seven research centers and a statistical coordinating center. Given current health care reform initiatives in the United States, this conceptual model can facilitate the development of comprehensive quality metrics for cancer screening and promote trans-organ comparative cancer screening research. PROSPR findings will support the design of interventions that improve screening outcomes across multiple cancer sites. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  5. Transition metal-catalyzed process for addition of amines to carbon-carbon double bonds

    DOEpatents

    Hartwig, John F.; Kawatsura, Motoi; Loeber, Oliver

    2002-01-01

    The present invention is directed to a process for addition of amines to carbon-carbon double bonds in a substrate, comprising: reacting an amine with a compound containing at least one carbon-carbon double bond in the presence a transition metal catalyst under reaction conditions effective to form a product having a covalent bond between the amine and a carbon atom of the former carbon-carbon double bond. The transition metal catalyst comprises a Group 8 metal and a ligand containing one or more 2-electron donor atoms. The present invention is also directed to enantioselective reactions of amine compounds with compounds containing carbon-carbon double bonds, and a calorimetric assay to evaluate potential catalysts in these reactions.

  6. Relaxation processes and glass transition of confined polymer melts: A molecular dynamics simulation of 1,4-polybutadiene between graphite walls.

    PubMed

    Solar, M; Binder, K; Paul, W

    2017-05-28

    Molecular dynamics simulations of a chemically realistic model for 1,4-polybutadiene in a thin film geometry confined by two graphite walls are presented. Previous work on melts in the bulk has shown that the model faithfully reproduces static and dynamic properties of the real material over a wide temperature range. The present work studies how these properties change due to nano-confinement. The focus is on orientational correlations observable in nuclear magnetic resonance experiments and on the local intermediate incoherent neutron scattering function, F s (q z , z, t), for distances z from the graphite walls in the range of a few nanometers. Temperatures from about 2T g down to about 1.15T g , where T g is the glass transition temperature in the bulk, are studied. It is shown that weakly attractive forces between the wall atoms and the monomers suffice to effectively bind a polymer coil that is near the wall. For a wide regime of temperatures, the Arrhenius-like adsorption/desorption kinetics of the monomers is the slowest process, while very close to T g the Vogel-Fulcher-Tammann-like α-relaxation takes over. The α-process is modified only for z≤1.2 nm due to the density changes near the walls, less than expected from studies of coarse-grained (bead-spring-type) models. The weakness of the surface effects on the glass transition in this case is attributed to the interplay of density changes near the wall with the torsional potential. A brief discussion of pertinent experiments is given.

  7. The Kepler End-to-End Model: Creating High-Fidelity Simulations to Test Kepler Ground Processing

    NASA Technical Reports Server (NTRS)

    Bryson, Stephen T.; Jenkins, Jon M.; Peters, Dan J.; Tenenbaum, Peter P.; Klaus, Todd C.; Gunter, Jay P.; Cote, Miles T.; Caldwell, Douglas A.

    2010-01-01

    The Kepler mission is designed to detect the transit of Earth-like planets around Sun-like stars by observing 100,000 stellar targets. Developing and testing the Kepler ground-segment processing system, in particular the data analysis pipeline, requires high-fidelity simulated data. This simulated data is provided by the Kepler End-to-End Model (ETEM). ETEM simulates the astrophysics of planetary transits and other phenomena, properties of the Kepler spacecraft and the format of the downlinked data. Major challenges addressed by ETEM include the rapid production of large amounts of simulated data, extensibility and maintainability.

  8. The democracy ochlocracy dictatorship transition in the Sznajd model and in the Ising model

    NASA Astrophysics Data System (ADS)

    Schneider, Johannes J.; Hirtreiter, Christian

    2005-08-01

    Since its introduction in 2000, the Sznajd model has been assumed to simulate a democratic community with two parties. The main flaw in this model is that a Sznajd system freezes in the long term in a non-democratic state, which can be either a dictatorship or a stalemate configuration. Here we show that the Sznajd model has better to be considered as a transition model, transferring a democratic system already at the beginning of a simulation via an ochlocratic scenario, i.e., a regime in which several mobs rule, to a dictatorship, thus reproducing the corresponding Aristotelian theory.

  9. Geometric structure and information change in phase transitions

    NASA Astrophysics Data System (ADS)

    Kim, Eun-jin; Hollerbach, Rainer

    2017-06-01

    We propose a toy model for a cyclic order-disorder transition and introduce a geometric methodology to understand stochastic processes involved in transitions. Specifically, our model consists of a pair of forward and backward processes (FPs and BPs) for the emergence and disappearance of a structure in a stochastic environment. We calculate time-dependent probability density functions (PDFs) and the information length L , which is the total number of different states that a system undergoes during the transition. Time-dependent PDFs during transient relaxation exhibit strikingly different behavior in FPs and BPs. In particular, FPs driven by instability undergo the broadening of the PDF with a large increase in fluctuations before the transition to the ordered state accompanied by narrowing the PDF width. During this stage, we identify an interesting geodesic solution accompanied by the self-regulation between the growth and nonlinear damping where the time scale τ of information change is constant in time, independent of the strength of the stochastic noise. In comparison, BPs are mainly driven by the macroscopic motion due to the movement of the PDF peak. The total information length L between initial and final states is much larger in BPs than in FPs, increasing linearly with the deviation γ of a control parameter from the critical state in BPs while increasing logarithmically with γ in FPs. L scales as |lnD | and D-1 /2 in FPs and BPs, respectively, where D measures the strength of the stochastic forcing. These differing scalings with γ and D suggest a great utility of L in capturing different underlying processes, specifically, diffusion vs advection in phase transition by geometry. We discuss physical origins of these scalings and comment on implications of our results for bistable systems undergoing repeated order-disorder transitions (e.g., fitness).

  10. Geometric structure and information change in phase transitions.

    PubMed

    Kim, Eun-Jin; Hollerbach, Rainer

    2017-06-01

    We propose a toy model for a cyclic order-disorder transition and introduce a geometric methodology to understand stochastic processes involved in transitions. Specifically, our model consists of a pair of forward and backward processes (FPs and BPs) for the emergence and disappearance of a structure in a stochastic environment. We calculate time-dependent probability density functions (PDFs) and the information length L, which is the total number of different states that a system undergoes during the transition. Time-dependent PDFs during transient relaxation exhibit strikingly different behavior in FPs and BPs. In particular, FPs driven by instability undergo the broadening of the PDF with a large increase in fluctuations before the transition to the ordered state accompanied by narrowing the PDF width. During this stage, we identify an interesting geodesic solution accompanied by the self-regulation between the growth and nonlinear damping where the time scale τ of information change is constant in time, independent of the strength of the stochastic noise. In comparison, BPs are mainly driven by the macroscopic motion due to the movement of the PDF peak. The total information length L between initial and final states is much larger in BPs than in FPs, increasing linearly with the deviation γ of a control parameter from the critical state in BPs while increasing logarithmically with γ in FPs. L scales as |lnD| and D^{-1/2} in FPs and BPs, respectively, where D measures the strength of the stochastic forcing. These differing scalings with γ and D suggest a great utility of L in capturing different underlying processes, specifically, diffusion vs advection in phase transition by geometry. We discuss physical origins of these scalings and comment on implications of our results for bistable systems undergoing repeated order-disorder transitions (e.g., fitness).

  11. Improving TOGAF ADM 9.1 Migration Planning Phase by ITIL V3 Service Transition

    NASA Astrophysics Data System (ADS)

    Hanum Harani, Nisa; Akhmad Arman, Arry; Maulana Awangga, Rolly

    2018-04-01

    Modification planning of business transformation involving technological utilization required a system of transition and migration planning process. Planning of system migration activity is the most important. The migration process is including complex elements such as business re-engineering, transition scheme mapping, data transformation, application development, individual involvement by computer and trial interaction. TOGAF ADM is the framework and method of enterprise architecture implementation. TOGAF ADM provides a manual refer to the architecture and migration planning. The planning includes an implementation solution, in this case, IT solution, but when the solution becomes an IT operational planning, TOGAF could not handle it. This paper presents a new model framework detail transitions process of integration between TOGAF and ITIL. We evaluated our models in field study inside a private university.

  12. [A systematic review of worldwide natural history models of colorectal cancer: classification, transition rate and a recommendation for developing Chinese population-specific model].

    PubMed

    Li, Z F; Huang, H Y; Shi, J F; Guo, C G; Zou, S M; Liu, C C; Wang, Y; Wang, L; Zhu, S L; Wu, S L; Dai, M

    2017-02-10

    Objective: To review the worldwide studies on natural history models among colorectal cancer (CRC), and to inform building a Chinese population-specific CRC model and developing a platform for further evaluation of CRC screening and other interventions in population in China. Methods: A structured literature search process was conducted in PubMed and the target publication dates were from January 1995 to December 2014. Information about classification systems on both colorectal cancer and precancer on corresponding transition rate, were extracted and summarized. Indicators were mainly expressed by the medians and ranges of annual progression or regression rate. Results: A total of 24 studies were extracted from 1 022 studies, most were from America ( n =9), but 2 from China including 1 from the mainland area, mainly based on Markov model ( n =22). Classification systems for adenomas included progression risk ( n =9) and the sizes of adenoma ( n =13, divided into two ways) as follows: 1) Based on studies where adenoma was risk-dependent, the median annual transition rates, from ' normal status' to ' non-advanced adenoma', 'non-advanced' to ' advanced' and ' advanced adenoma' to CRC were 0.016 0 (range: 0.002 2-0.020 0), 0.020 (range: 0.002-0.177) and 0.044 (range: 0.005-0.063), respectively. 2) Median annual transition rates, based on studies where adenoma were classified by sizes, into <10 mm and ≥10 mm ( n =7), from ' normal' to adenoma <10 mm, from adenoma <10 mm to adenoma ≥10 mm and adenoma ≥ 10 mm to CRC, were 0.016 7 (range: 0.015 0-0.037 0), 0.020 (range: 0.015-0.035) and 0.040 0 (range: 0.008 5-0.050 0), respectively. 3) Median annual transition rates, based on studies where adenoma, were classified by sizes into diminutive (≤5 mm), small (6-9 mm) and large adenoma (≥10 mm) ( n =6), from ' normal' to diminutive adenoma,'diminutive' to ' small','small' to ' large', and large adenoma to CRC were 0.013 (range: 0.009-0.019), 0.043 (range: 0

  13. Employment, Production and Consumption model: Patterns of phase transitions

    NASA Astrophysics Data System (ADS)

    Lavička, H.; Lin, L.; Novotný, J.

    2010-04-01

    We have simulated the model of Employment, Production and Consumption (EPC) using Monte Carlo. The EPC model is an agent based model that mimics very basic rules of industrial economy. From the perspective of physics, the nature of the interactions in the EPC model represents multi-agent interactions where the relations among agents follow the key laws for circulation of capital and money. Monte Carlo simulations of the stochastic model reveal phase transition in the model economy. The two phases are the phase with full unemployment and the phase with nearly full employment. The economy switches between these two states suddenly as a reaction to a slight variation in the exogenous parameter, thus the system exhibits strong non-linear behavior as a response to the change of the exogenous parameters.

  14. Hysteretic transitions in the Kuramoto model with inertia.

    PubMed

    Olmi, Simona; Navas, Adrian; Boccaletti, Stefano; Torcini, Alessandro

    2014-10-01

    We report finite-size numerical investigations and mean-field analysis of a Kuramoto model with inertia for fully coupled and diluted systems. In particular, we examine, for a gaussian distribution of the frequencies, the transition from incoherence to coherence for increasingly large system size and inertia. For sufficiently large inertia the transition is hysteretic, and within the hysteretic region clusters of locked oscillators of various sizes and different levels of synchronization coexist. A modification of the mean-field theory developed by Tanaka, Lichtenberg, and Oishi [Physica D 100, 279 (1997)] allows us to derive the synchronization curve associated to each of these clusters. We have also investigated numerically the limits of existence of the coherent and of the incoherent solutions. The minimal coupling required to observe the coherent state is largely independent of the system size, and it saturates to a constant value already for moderately large inertia values. The incoherent state is observable up to a critical coupling whose value saturates for large inertia and for finite system sizes, while in the thermodinamic limit this critical value diverges proportionally to the mass. By increasing the inertia the transition becomes more complex, and the synchronization occurs via the emergence of clusters of whirling oscillators. The presence of these groups of coherently drifting oscillators induces oscillations in the order parameter. We have shown that the transition remains hysteretic even for randomly diluted networks up to a level of connectivity corresponding to a few links per oscillator. Finally, an application to the Italian high-voltage power grid is reported, which reveals the emergence of quasiperiodic oscillations in the order parameter due to the simultaneous presence of many competing whirling clusters.

  15. Multistakeholder Perspectives on the Transition to a Graduate-Level Athletic Training Educational Model

    PubMed Central

    Mazerolle, Stephanie M.; Bowman, Thomas G.; Pitney, William A.

    2015-01-01

    Context  The decision has been made to move away from the traditional bachelor's degree professional program to a master's degree professional program. Little is known about the perceptions about this transition from those involved with education. Objective  To examine multiple stakeholders' perspectives within athletic training education on the effect that a change to graduate-level education could have on the profession and the educational and professional development of the athletic trainer. Design  Qualitative study. Setting  Web-based survey. Patients or Other Participants  A total of 18 athletic training students (6 men, 12 women; age = 24 ± 5 years), 17 athletic training faculty (6 men, 9 women, 2 unspecified; 7 program directors, 5 faculty members, 3 clinical coordinators, 2 unidentified; age = 45 ± 8 years), and 15 preceptors (7 men, 7 women, 1 unspecified; age = 34 ± 7 years) completed the study. Data Collection and Analysis  Participants completed a structured Web-based questionnaire. Each cohort responded to questions matching their roles within an athletic training program. Data were analyzed following a general inductive process. Member checks, multiple-analyst triangulation, and peer review established credibility. Results  Thirty-one (62%) participants supported the transition, 14 (28%) were opposed, and 5 (10%) were neutral or undecided. Advantages of and support for transitioning and disadvantages of and against transitioning emerged. The first higher-order theme, advantages, revealed 4 benefits: (1) alignment of athletic training with other health care professions, (2) advanced coursework and curriculum delivery, (3) improved student and professional retention, and (4) student maturity. The second higher-order theme, disadvantages, was defined by 3 factors: (1) limited time for autonomous practice, (2) financial concerns, and (3) lack of evidence for the transition. Conclusions  Athletic training students, faculty, and

  16. Transcriptome of the floral transition in Rosa chinensis 'Old Blush'.

    PubMed

    Guo, Xuelian; Yu, Chao; Luo, Le; Wan, Huihua; Zhen, Ni; Xu, Tingliang; Tan, Jiongrui; Pan, Huitang; Zhang, Qixiang

    2017-02-23

    The floral transition plays a vital role in the life of ornamental plants. Despite progress in model plants, the molecular mechanisms of flowering regulation remain unknown in perennial plants. Rosa chinensis 'Old Blush' is a unique plant that can flower continuously year-round. In this study, gene expression profiles associated with the flowering transition were comprehensively analyzed during floral transition in the rose. According to the transcriptomic profiles, 85,663 unigenes and 1,637 differentially expressed genes (DEGs) were identified, among which 32 unigenes were involved in the circadian clock, sugar metabolism, hormone, and autonomous pathways. A hypothetical model for the regulation of floral transition was proposed in which the candidate genes function synergistically the floral transition process. Hormone contents and biosynthesis and metabolism genes fluctuated during the rose floral transition process. Gibberellins (GAs) inhibited rose floral transition, the content of GAs gradually decreased and GA2ox and SCL13 were upregulated from vegetative (VM) meristem to floral meristem (FM). Auxin plays an affirmative part in mediating floral transition, auxin content and auxin-related gene expression levels were gradually upregulated during the floral transition of the rose. However, ABA content and ABA signal genes were gradually downregulated, suggesting that ABA passively regulates the rose floral transition by participating in sugar signaling. Furthermore, sugar content and sugar metabolism genes increased during floral transition in the rose, which may be a further florigenic signal that activates floral transition. Additionally, FRI, FY, DRM1, ELIP, COP1, CO, and COL16 are involved in the circadian clock and autonomous pathway, respectively, and they play a positively activating role in regulating floral transition. Overall, physiological changes associated with genes involved in the circadian clock or autonomous pathway collectively regulated the

  17. A covariant model for the gamma N -> N(1535) transition at high momentum transfer

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    G. Ramalho, M.T. Pena

    2011-08-01

    A relativistic constituent quark model is applied to the gamma N -> N(1535) transition. The N(1535) wave function is determined by extending the covariant spectator quark model, previously developed for the nucleon, to the S11 resonance. The model allows us to calculate the valence quark contributions to the gamma N -> N(1535) transition form factors. Because of the nucleon and N(1535) structure the model is valid only for Q^2> 2.3 GeV^2. The results are compared with the experimental data for the electromagnetic form factors F1* and F2* and the helicity amplitudes A_1/2 and S_1/2, at high Q^2.

  18. Two ecological models of academic achievement among diverse students with and without disabilities in transition.

    PubMed

    Williams, Terrinieka T; McMahon, Susan D; Keys, Christopher B

    2014-01-01

    School experiences can have positive effects on student academic achievement, yet less is known about intermediary processes that contribute to these positive effects. We examined pathways between school experiences and academic achievement among 117 low-income urban students of color, many with disabilities, who transitioned to other schools following a school closure. Using structural equation modeling, we tested two ecological models that examined the relationships among self-reported school experiences, school support, academic self-efficacy, and school-reported academic achievement. The model in which the relationship between school experiences and academic achievement is mediated by both school support and academic self-efficacy, and that takes previous academic achievement into account, was an excellent fit with the data. The roles of contextual and individual factors as they relate to academic achievement, and the implications of these findings, are discussed.

  19. Dynamic Transcription Factor Networks in Epithelial-Mesenchymal Transition in Breast Cancer Models

    PubMed Central

    Siletz, Anaar; Schnabel, Michael; Kniazeva, Ekaterina; Schumacher, Andrew J.; Shin, Seungjin; Jeruss, Jacqueline S.; Shea, Lonnie D.

    2013-01-01

    The epithelial-mesenchymal transition (EMT) is a complex change in cell differentiation that allows breast carcinoma cells to acquire invasive properties. EMT involves a cascade of regulatory changes that destabilize the epithelial phenotype and allow mesenchymal features to manifest. As transcription factors (TFs) are upstream effectors of the genome-wide expression changes that result in phenotypic change, understanding the sequential changes in TF activity during EMT provides rich information on the mechanism of this process. Because molecular interactions will vary as cells progress from an epithelial to a mesenchymal differentiation program, dynamic networks are needed to capture the changing context of molecular processes. In this study we applied an emerging high-throughput, dynamic TF activity array to define TF activity network changes in three cell-based models of EMT in breast cancer based on HMLE Twist ER and MCF-7 mammary epithelial cells. The TF array distinguished conserved from model-specific TF activity changes in the three models. Time-dependent data was used to identify pairs of TF activities with significant positive or negative correlation, indicative of interdependent TF activity throughout the six-day study period. Dynamic TF activity patterns were clustered into groups of TFs that change along a time course of gene expression changes and acquisition of invasive capacity. Time-dependent TF activity data was combined with prior knowledge of TF interactions to construct dynamic models of TF activity networks as epithelial cells acquire invasive characteristics. These analyses show EMT from a unique and targetable vantage and may ultimately contribute to diagnosis and therapy. PMID:23593114

  20. Dynamic transcription factor networks in epithelial-mesenchymal transition in breast cancer models.

    PubMed

    Siletz, Anaar; Schnabel, Michael; Kniazeva, Ekaterina; Schumacher, Andrew J; Shin, Seungjin; Jeruss, Jacqueline S; Shea, Lonnie D

    2013-01-01

    The epithelial-mesenchymal transition (EMT) is a complex change in cell differentiation that allows breast carcinoma cells to acquire invasive properties. EMT involves a cascade of regulatory changes that destabilize the epithelial phenotype and allow mesenchymal features to manifest. As transcription factors (TFs) are upstream effectors of the genome-wide expression changes that result in phenotypic change, understanding the sequential changes in TF activity during EMT provides rich information on the mechanism of this process. Because molecular interactions will vary as cells progress from an epithelial to a mesenchymal differentiation program, dynamic networks are needed to capture the changing context of molecular processes. In this study we applied an emerging high-throughput, dynamic TF activity array to define TF activity network changes in three cell-based models of EMT in breast cancer based on HMLE Twist ER and MCF-7 mammary epithelial cells. The TF array distinguished conserved from model-specific TF activity changes in the three models. Time-dependent data was used to identify pairs of TF activities with significant positive or negative correlation, indicative of interdependent TF activity throughout the six-day study period. Dynamic TF activity patterns were clustered into groups of TFs that change along a time course of gene expression changes and acquisition of invasive capacity. Time-dependent TF activity data was combined with prior knowledge of TF interactions to construct dynamic models of TF activity networks as epithelial cells acquire invasive characteristics. These analyses show EMT from a unique and targetable vantage and may ultimately contribute to diagnosis and therapy.

  1. Multiple Phase Transitions in the model multiferroic BiFeO3

    NASA Astrophysics Data System (ADS)

    Kreisel, Jens

    2012-02-01

    Bismuth ferrite BiFeO3 (BFO) is commonly considered a model system for multiferroics, and is perhaps the only material that is both magnetic and a ferroelectric with a strong electric polarization at 300K [1]. Despite numerous investigations, the crystal structures of BFO as a function of temperature and pressure are still not established and lead to ongoing controversial reports in the literature [1,3]. Besides being a model multiferroic, BFO is also one of the very few materials that present both octahedra tilts and strong cation displacements at room temperature. Here we report the high-pressure phase transitions in BFO by both synchrotron x-ray diffraction and Raman spectroscopy, namely a surprising richness of six phase transitions in the 0--60 GPa range [2-3]. At low pressures, 4 transitions are evidenced at 4, 6, 7 and 11 GPa. In this range, the crystals display in that range unusual large unit cells and complex domain structures, which suggests a competition between complex tilt systems and possibly off-center cation displacements. The non polar Pnma phase remains stable over a large pressure range between 11 and 38 GPa. The two high pressure phase transitions at 38 and 48 GPa are marked by the occurrence of larger unit cells and an increase of the distortion away from the cubic parent perovskite cell. The previously reported insulator-to-metal transition appears to be symmetry breaking. Finally, we will present a new schematic P-T phase diagram for BFO and discuss the recently reported phase transition in highly strained BFO films [4,5] in the light of our high-pressure findings. [4pt] [1] G. Catalan, J. F. Scott, Advanced Materials 21, 1 (2009).[0pt] [2] R. Haumont et al., Phys. Rev. B 79, 184110 (2009).[0pt] [3] M. Guennou et al., Phys. Rev. B 2011, accepted http://arxiv.org/abs/1108.0704.2011[0pt] [4] J. Kreisel et al. J. Phys.: Cond. Matt. 23, 342202 (2011).[0pt] [5] W. Siemons et al. Appl. Phys. Express 4 (2011).

  2. Numerical modeling of the transitional boundary layer over a flat plate

    NASA Astrophysics Data System (ADS)

    Ivanov, Dimitry; Chorny, Andrei

    2015-11-01

    Our example is connected with fundamental research on understanding how an initially laminar boundary layer becomes turbulent. We have chosen the flow over a flat plate as a prototype for boundary-layer flows around bodies. Special attention was paid to the near-wall region in order to capture all levels of the boundary layer. In this study, the numerical software package OpenFOAM has been used in order to solve the flow field. The results were used in a comparative study with data obtained from Large Eddy Simulation (LES). The composite SGS-wall model is presently incorporated into a computer code suitable for the LES of developing flat-plate boundary layers. Presently this model is extended to the LES of the zero-pressure gradient, flat-plate turbulent boundary layer. In current study the time discretization is based on a second order Crank-Nicolson/Adams-Bashforth method. LES solver using Smagorinsky and the one-equation LES turbulence models. The transition models significantly improve the prediction of the onset location compared to the fully turbulent models.LES methods appear to be the most promising new tool for the design and analysis of flow devices including transition regions of the turbulent flow.

  3. Energy Landscape and Transition State of Protein-Protein Association

    NASA Astrophysics Data System (ADS)

    Alsallaq, Ramzi; Zhou, Huan-Xiang

    2006-11-01

    Formation of a stereospecific protein complex is favored by specific interactions between two proteins but disfavored by the loss of translational and rotational freedom. Echoing the protein folding process, we have previously proposed a transition state for protein-protein association. Here we clarify the specification of the transition state by working with two toy models for protein association. The models demonstrate that a sharp transition between the bound state with numerous short-range interactions but restricted translation and rotational freedom and the unbound state with at most a small number of interactions but expanded configurational freedom. This transition sets the outer boundary of the bound state as well as the transition state for association. The energy landscape is funnel-like, with the deep well of the bound state surrounded by a broad shallow basin. This formalism of protein-protein association is applied to four protein-protein complexes, and is found to give accurate predictions for the effects of charge mutations and ionic strength on the association rates.

  4. A kinetic Monte Carlo simulation method of van der Waals epitaxy for atomistic nucleation-growth processes of transition metal dichalcogenides.

    PubMed

    Nie, Yifan; Liang, Chaoping; Cha, Pil-Ryung; Colombo, Luigi; Wallace, Robert M; Cho, Kyeongjae

    2017-06-07

    Controlled growth of crystalline solids is critical for device applications, and atomistic modeling methods have been developed for bulk crystalline solids. Kinetic Monte Carlo (KMC) simulation method provides detailed atomic scale processes during a solid growth over realistic time scales, but its application to the growth modeling of van der Waals (vdW) heterostructures has not yet been developed. Specifically, the growth of single-layered transition metal dichalcogenides (TMDs) is currently facing tremendous challenges, and a detailed understanding based on KMC simulations would provide critical guidance to enable controlled growth of vdW heterostructures. In this work, a KMC simulation method is developed for the growth modeling on the vdW epitaxy of TMDs. The KMC method has introduced full material parameters for TMDs in bottom-up synthesis: metal and chalcogen adsorption/desorption/diffusion on substrate and grown TMD surface, TMD stacking sequence, chalcogen/metal ratio, flake edge diffusion and vacancy diffusion. The KMC processes result in multiple kinetic behaviors associated with various growth behaviors observed in experiments. Different phenomena observed during vdW epitaxy process are analysed in terms of complex competitions among multiple kinetic processes. The KMC method is used in the investigation and prediction of growth mechanisms, which provide qualitative suggestions to guide experimental study.

  5. TRANSIT MODEL OF PLANETS WITH MOON AND RING SYSTEMS

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tusnski, Luis Ricardo M.; Valio, Adriana, E-mail: lrtusnski@das.inpe.br, E-mail: avalio@craam.mackenzie.br

    2011-12-10

    Since the discovery of the first exoplanets, those most adequate for life to begin and evolve have been sought. Due to observational bias, however, most of the discovered planets so far are gas giants, precluding their habitability. However, if these hot Jupiters are located in the habitable zones of their host stars, and if rocky moons orbit them, then these moons may be habitable. In this work, we present a model for planetary transit simulation considering the presence of moons and planetary rings around a planet. The moon's orbit is considered to be circular and coplanar with the planetary orbit.more » The other physical and orbital parameters of the star, planet, moon, and rings can be adjusted in each simulation. It is possible to simulate as many successive transits as desired. Since the presence of spots on the surface of the star may produce a signal similar to that of the presence of a moon, our model also allows for the inclusion of starspots. The result of the simulation is a light curve with a planetary transit. White noise may also be added to the light curves to produce curves similar to those obtained by the CoRoT and Kepler space telescopes. The goal is to determine the criteria for detectability of moons and/or ring systems using photometry. The results show that it is possible to detect moons with radii as little as 1.3 R{sub Circled-Plus} with CoRoT and 0.3 R{sub Circled-Plus} with Kepler.« less

  6. Magnetic dipole transitions of Bc and Bc* mesons in the relativistic independent quark model

    NASA Astrophysics Data System (ADS)

    Patnaik, Sonali; Dash, P. C.; Kar, Susmita; Patra, Sweta P.; Barik, N.

    2017-12-01

    We study M1-transitions involving mesons: Bc(1 s ), Bc*(1 s ), Bc(2 s ), Bc*(2 s ), Bc(3 s ), and Bc*(3 s ) in the relativistic independent quark (RIQ) model based on a flavor independent average potential in the scalar-vector harmonic form. The transition form factor for Bc*→Bcγ is found to have analytical continuation from spacelike to physical timelike region. Our predicted coupling constant gBc*Bc=0.34 GeV-1 and decay width Γ (Bc*→Bcγ )=23 eV agree with other model predictions. In view of possible observation of Bc and Bc* s-wave states at LHC and Z-factory and potential use of theoretical estimate on M1-transitions, we investigate the allowed as well as hindered transitions of orbitally excited Bc-meson states and predict their decay widths in overall agreement with other model predictions. We consider the typical case of Bc*(1 s )→Bc(1 s )γ , where our predicted decay width which is found quite sensitive to the mass difference between Bc* and Bc mesons may help in determining the mass of Bc* experimentally.

  7. The Current Landscape of Transitions of Care Practice Models: A Scoping Review.

    PubMed

    Rochester-Eyeguokan, Charmaine D; Pincus, Kathleen J; Patel, Roshni S; Reitz, Shirley J

    2016-01-01

    Transitions of care (TOC) are a set of actions to ensure patient coordination and continuity of care as patients transfer between different locations or levels. During transitions associated with chronic or acute illness, vulnerable patients may be placed at risk with fragmented systems compromising their health and safety. In addition, poor care transitions also have an enormous impact on health care spending. The primary objective of this scoping review is to summarize the current landscape of practice models that deliver TOC services in the United States. The secondary objective is to use the information to characterize the current state of best practice models. A search of the PubMed, Embase, Cumulative Index to Nursing and Allied Health Literature, Web of Science, International Pharmaceutical Abstracts, National Center for Biotechnology Information at the U.S. National Library of Medicine, and Cochrane Library databases (January 1, 2000-April 13, 2015) for articles pertaining to TOC models, limited to U.S. studies published in the English language with human subjects, gleaned 1362 articles. An additional 26 articles were added from the gray literature. Articles meeting inclusion criteria underwent a second review and were categorized into four groups: background information, original TOC research articles not evaluating practice model interventions, original TOC research articles describing practice models, and systematic or Cochrane reviews. The reviewers met weekly to discuss the challenges and resolve disagreements regarding literature reviews with consensus before progressing. A total of 188 articles describing TOC practice models met the inclusion criteria. Despite the strengths of several quality TOC models, none satisfied all the components recommended by leading experts. Multimodal interventions by multidisciplinary teams appear to represent a best practice model for TOC to improve patient outcomes and reduce readmissions, but one size does not fit all

  8. Mott metal-insulator transition in the doped Hubbard-Holstein model

    NASA Astrophysics Data System (ADS)

    Kurdestany, Jamshid Moradi; Satpathy, S.

    2017-08-01

    Motivated by the current interest in the understanding of the Mott insulators away from half-filling, observed in many perovskite oxides, we study the Mott metal-insulator transition in the doped Hubbard-Holstein model using the Hartree-Fock mean field theory. The Hubbard-Holstein model is the simplest model containing both the Coulomb and the electron-lattice interactions, which are important ingredients in the physics of the perovskite oxides. In contrast to the half-filled Hubbard model, which always results in a single phase (either metallic or insulating), our results show that away from half-filling, a mixed phase of metallic and insulating regions occurs. As the dopant concentration is increased, the metallic part progressively grows in volume, until it exceeds the percolation threshold, leading to percolative conduction. This happens above a critical dopant concentration δc, which, depending on the strength of the electron-lattice interaction, can be a significant fraction of unity. This means that the material could be insulating even for a substantial amount of doping, in contrast to the expectation that doped holes would destroy the insulating behavior of the half-filled Hubbard model. While effects of fluctuation beyond the mean field remain an open question, our results provide a starting point for the understanding of the density-driven metal-insulator transition observed in many complex oxides.

  9. Bridging analytical approaches for low-carbon transitions

    NASA Astrophysics Data System (ADS)

    Geels, Frank W.; Berkhout, Frans; van Vuuren, Detlef P.

    2016-06-01

    Low-carbon transitions are long-term multi-faceted processes. Although integrated assessment models have many strengths for analysing such transitions, their mathematical representation requires a simplification of the causes, dynamics and scope of such societal transformations. We suggest that integrated assessment model-based analysis should be complemented with insights from socio-technical transition analysis and practice-based action research. We discuss the underlying assumptions, strengths and weaknesses of these three analytical approaches. We argue that full integration of these approaches is not feasible, because of foundational differences in philosophies of science and ontological assumptions. Instead, we suggest that bridging, based on sequential and interactive articulation of different approaches, may generate a more comprehensive and useful chain of assessments to support policy formation and action. We also show how these approaches address knowledge needs of different policymakers (international, national and local), relate to different dimensions of policy processes and speak to different policy-relevant criteria such as cost-effectiveness, socio-political feasibility, social acceptance and legitimacy, and flexibility. A more differentiated set of analytical approaches thus enables a more differentiated approach to climate policy making.

  10. Analysis of flow disturbance in a stenosed carotid artery bifurcation using two-equation transitional and turbulence models.

    PubMed

    Tan, F P P; Soloperto, G; Bashford, S; Wood, N B; Thom, S; Hughes, A; Xu, X Y

    2008-12-01

    In this study, newly developed two-equation turbulence models and transitional variants are employed for the prediction of blood flow patterns in a diseased carotid artery where the growth, progression, and structure of the plaque at rupture are closely linked to low and oscillating wall shear stresses. Moreover, the laminar-turbulent transition in the poststenotic zone can alter the separation zone length, wall shear stress, and pressure distribution over the plaque, with potential implications for stresses within the plaque. Following the validation with well established experimental measurements and numerical studies, a magnetic-resonance (MR) image-based model of the carotid bifurcation with 70% stenosis was reconstructed and simulated using realistic patient-specific conditions. Laminar flow, a correlation-based transitional version of Menter's hybrid k-epsilon/k-omega shear stress transport (SST) model and its "scale adaptive simulation" (SAS) variant were implemented in pulsatile simulations from which analyses of velocity profiles, wall shear stress, and turbulence intensity were conducted. In general, the transitional version of SST and its SAS variant are shown to give a better overall agreement than their standard counterparts with experimental data for pulsatile flow in an axisymmetric stenosed tube. For the patient-specific case reported, the wall shear stress analysis showed discernable differences between the laminar flow and SST transitional models but virtually no difference between the SST transitional model and its SAS variant.

  11. Mathematical models of tissue stem and transit target cell divisions and the risk of radiation- or smoking-associated cancer

    PubMed Central

    Hendry, Jolyon H.

    2017-01-01

    There is compelling biological data to suggest that cancer arises from a series of mutations in single target cells, resulting in defects in cell renewal and differentiation processes which lead to malignancy. Because much mutagenic damage is expressed following cell division, more-rapidly renewing tissues could be at higher risk because of the larger number of cell replications. Cairns suggested that renewing tissues may reduce cancer risk by partitioning the dividing cell populations into lineages comprising infrequently-dividing long-lived stem cells and frequently-dividing short-lived daughter transit cells. We develop generalizations of three recent cancer-induction models that account for the joint maintenance and renewal of stem and transit cells, also competing processes of partially transformed cell proliferation and differentiation/apoptosis. We are particularly interested in using these models to separately assess the probabilities of mutation and development of cancer associated with “spontaneous” processes and with those linked to a specific environmental mutagen, specifically ionizing radiation or cigarette smoking. All three models demonstrate substantial variation in cancer risks, by at least 20 orders of magnitude, depending on the assumed number of critical mutations required for cancer, and the stem-cell and transition-cell mutation rates. However, in most cases the conditional probabilities of cancer being mutagen-induced range between 7–96%. The relative risks associated with mutagen exposure compared to background rates are also stable, ranging from 1.0–16.0. Very few cancers, generally <0.5%, arise from mutations occurring solely in stem cells rather than in a combination of stem and transit cells. However, for cancers with 2 or 3 critical mutations, a substantial proportion of cancers, in some cases 100%, have at least one mutation derived from a mutated stem cell. Little difference is made to relative risks if competing processes of

  12. Mathematical models of tissue stem and transit target cell divisions and the risk of radiation- or smoking-associated cancer.

    PubMed

    Little, Mark P; Hendry, Jolyon H

    2017-02-01

    There is compelling biological data to suggest that cancer arises from a series of mutations in single target cells, resulting in defects in cell renewal and differentiation processes which lead to malignancy. Because much mutagenic damage is expressed following cell division, more-rapidly renewing tissues could be at higher risk because of the larger number of cell replications. Cairns suggested that renewing tissues may reduce cancer risk by partitioning the dividing cell populations into lineages comprising infrequently-dividing long-lived stem cells and frequently-dividing short-lived daughter transit cells. We develop generalizations of three recent cancer-induction models that account for the joint maintenance and renewal of stem and transit cells, also competing processes of partially transformed cell proliferation and differentiation/apoptosis. We are particularly interested in using these models to separately assess the probabilities of mutation and development of cancer associated with "spontaneous" processes and with those linked to a specific environmental mutagen, specifically ionizing radiation or cigarette smoking. All three models demonstrate substantial variation in cancer risks, by at least 20 orders of magnitude, depending on the assumed number of critical mutations required for cancer, and the stem-cell and transition-cell mutation rates. However, in most cases the conditional probabilities of cancer being mutagen-induced range between 7-96%. The relative risks associated with mutagen exposure compared to background rates are also stable, ranging from 1.0-16.0. Very few cancers, generally <0.5%, arise from mutations occurring solely in stem cells rather than in a combination of stem and transit cells. However, for cancers with 2 or 3 critical mutations, a substantial proportion of cancers, in some cases 100%, have at least one mutation derived from a mutated stem cell. Little difference is made to relative risks if competing processes of

  13. Velocity mode transition of dynamic crack propagation in hyperviscoelastic materials: A continuum model study

    PubMed Central

    Kubo, Atsushi; Umeno, Yoshitaka

    2017-01-01

    Experiments of crack propagation in rubbers have shown that a discontinuous jump of crack propagation velocity can occur as energy release rate increases, which is known as the “mode transition” phenomenon. Although it is believed that the mode transition is strongly related to the mechanical properties, the nature of the mode transition had not been revealed. In this study, dynamic crack propagation on an elastomer was investigated using the finite element method (FEM) with a hyperviscoelastic material model. A series of pure shear test was carried out numerically with FEM simulations and crack velocities were measured under various values of tensile strain. As a result, our FEM simulations successfully reproduced the mode transition. The success of realising the mode transition phenomenon by a simple FEM model, which was achieved for the first time ever, helped to explain that the phenomenon occurs owing to a characteristic non-monotonic temporal development of principal stress near the crack tip. PMID:28186205

  14. Velocity mode transition of dynamic crack propagation in hyperviscoelastic materials: A continuum model study

    NASA Astrophysics Data System (ADS)

    Kubo, Atsushi; Umeno, Yoshitaka

    2017-02-01

    Experiments of crack propagation in rubbers have shown that a discontinuous jump of crack propagation velocity can occur as energy release rate increases, which is known as the “mode transition” phenomenon. Although it is believed that the mode transition is strongly related to the mechanical properties, the nature of the mode transition had not been revealed. In this study, dynamic crack propagation on an elastomer was investigated using the finite element method (FEM) with a hyperviscoelastic material model. A series of pure shear test was carried out numerically with FEM simulations and crack velocities were measured under various values of tensile strain. As a result, our FEM simulations successfully reproduced the mode transition. The success of realising the mode transition phenomenon by a simple FEM model, which was achieved for the first time ever, helped to explain that the phenomenon occurs owing to a characteristic non-monotonic temporal development of principal stress near the crack tip.

  15. A general stochastic model for studying time evolution of transition networks

    NASA Astrophysics Data System (ADS)

    Zhan, Choujun; Tse, Chi K.; Small, Michael

    2016-12-01

    We consider a class of complex networks whose nodes assume one of several possible states at any time and may change their states from time to time. Such networks represent practical networks of rumor spreading, disease spreading, language evolution, and so on. Here, we derive a model describing the dynamics of this kind of network and a simulation algorithm for studying the network evolutionary behavior. This model, derived at a microscopic level, can reveal the transition dynamics of every node. A numerical simulation is taken as an ;experiment; or ;realization; of the model. We use this model to study the disease propagation dynamics in four different prototypical networks, namely, the regular nearest-neighbor (RN) network, the classical Erdös-Renyí (ER) random graph, the Watts-Strogátz small-world (SW) network, and the Barabási-Albert (BA) scalefree network. We find that the disease propagation dynamics in these four networks generally have different properties but they do share some common features. Furthermore, we utilize the transition network model to predict user growth in the Facebook network. Simulation shows that our model agrees with the historical data. The study can provide a useful tool for a more thorough understanding of the dynamics networks.

  16. Non-resonant collider signatures of a singlet-driven electroweak phase transition

    NASA Astrophysics Data System (ADS)

    Chen, Chien-Yi; Kozaczuk, Jonathan; Lewis, Ian M.

    2017-08-01

    We analyze the collider signatures of the real singlet extension of the Standard Model in regions consistent with a strong first-order electroweak phase transition and a singlet-like scalar heavier than the Standard Model-like Higgs. A definitive correlation exists between the strength of the phase transition and the trilinear coupling of the Higgs to two singlet-like scalars, and hence between the phase transition and non-resonant scalar pair production involving the singlet at colliders. We study the prospects for observing these processes at the LHC and a future 100 TeV pp collider, focusing particularly on double singlet production. We also discuss correlations between the strength of the electroweak phase transition and other observables at hadron and future lepton colliders. Searches for non-resonant singlet-like scalar pair production at 100 TeV would provide a sensitive probe of the electroweak phase transition in this model, complementing resonant di-Higgs searches and precision measurements. Our study illustrates a strategy for systematically exploring the phenomenologically viable parameter space of this model, which we hope will be useful for future work.

  17. Stakeholder validation of a model of readiness for transition to adult care.

    PubMed

    Schwartz, Lisa A; Brumley, Lauren D; Tuchman, Lisa K; Barakat, Lamia P; Hobbie, Wendy L; Ginsberg, Jill P; Daniel, Lauren C; Kazak, Anne E; Bevans, Katherine; Deatrick, Janet A

    2013-10-01

    That too few youth with special health care needs make the transition to adult-oriented health care successfully may be due, in part, to lack of readiness to transfer care. There is a lack of theoretical models to guide development and implementation of evidence-based guidelines, assessments, and interventions to improve transition readiness. To further validate the Social-ecological Model of Adolescent and Young Adult Readiness to Transition (SMART) via feedback from stakeholders (patients, parents, and providers) from a medically diverse population in need of life-long follow-up care, survivors of childhood cancer. Mixed-methods participatory research design. A large Mid-Atlantic children's hospital. Adolescent and young adult survivors of childhood cancer (n = 14), parents (n = 18), and pediatric providers (n = 10). Patients and parents participated in focus groups; providers participated in individual semi-structured interviews. Validity of SMART was assessed 3 ways: (1) ratings on importance of SMART components for transition readiness using a 5-point scale (0-4; ratings >2 support validity), (2) nominations of 3 "most important" components, and (3) directed content analysis of focus group/interview transcripts. Qualitative data supported the validity of SMART, with minor modifications to definitions of components. Quantitative ratings met criteria for validity; stakeholders endorsed all components of SMART as important for transition. No additional SMART variables were suggested by stakeholders and the "most important" components varied by stakeholders, thus supporting the comprehensiveness of SMART and need to involve multiple perspectives. SMART represents a comprehensive and empirically validated framework for transition research and program planning, supported by survivors of childhood cancer, parents, and pediatric providers. Future research should validate SMART among other populations with special health care needs.

  18. A phenomenological model for simulating the chemo-responsive shape memory effect in polymers undergoing a permeation transition

    NASA Astrophysics Data System (ADS)

    Lu, Haibao; Huang, Wei Min; Leng, Jinsong

    2014-04-01

    We present a phenomenological model for studying the constitutive relations and working mechanism of the chemo-responsive shape memory effect (SME) in shape memory polymers (SMPs). On the basis of the solubility parameter equation, diffusion model and permeation transition model, a phenomenological model is derived for quantitatively identifying the influential factors in the chemically induced SME in SMPs. After this, a permeability parallel model and series model are implemented in order to couple the constitutive relations of the permeability coefficient, stress and relaxation time as a function of stretch, separately. The inductive effect of the permeability transition on the transition temperature is confirmed as the driving force for the chemo-responsive SME. Furthermore, the analytical result from the phenomenological model is compared with the available experimental results and the simulation of a semi-empirical model reported in the literature for verification.

  19. Discrete event simulation tool for analysis of qualitative models of continuous processing systems

    NASA Technical Reports Server (NTRS)

    Malin, Jane T. (Inventor); Basham, Bryan D. (Inventor); Harris, Richard A. (Inventor)

    1990-01-01

    An artificial intelligence design and qualitative modeling tool is disclosed for creating computer models and simulating continuous activities, functions, and/or behavior using developed discrete event techniques. Conveniently, the tool is organized in four modules: library design module, model construction module, simulation module, and experimentation and analysis. The library design module supports the building of library knowledge including component classes and elements pertinent to a particular domain of continuous activities, functions, and behavior being modeled. The continuous behavior is defined discretely with respect to invocation statements, effect statements, and time delays. The functionality of the components is defined in terms of variable cluster instances, independent processes, and modes, further defined in terms of mode transition processes and mode dependent processes. Model construction utilizes the hierarchy of libraries and connects them with appropriate relations. The simulation executes a specialized initialization routine and executes events in a manner that includes selective inherency of characteristics through a time and event schema until the event queue in the simulator is emptied. The experimentation and analysis module supports analysis through the generation of appropriate log files and graphics developments and includes the ability of log file comparisons.

  20. A joint modelling approach for multistate processes subject to resolution and under intermittent observations.

    PubMed

    Yiu, Sean; Tom, Brian

    2017-02-10

    Multistate processes provide a convenient framework when interest lies in characterising the transition intensities between a set of defined states. If, however, there is an unobserved event of interest (not known if and when the event occurs), which when it occurs stops future transitions in the multistate process from occurring, then drawing inference from the joint multistate and event process can be problematic. In health studies, a particular example of this could be resolution, where a resolved patient can no longer experience any further symptoms, and this is explored here for illustration. A multistate model that includes the state space of the original multistate process but partitions the state representing absent symptoms into a latent absorbing resolved state and a temporary transient state of absent symptoms is proposed. The expanded state space explicitly distinguishes between resolved and temporary spells of absent symptoms through disjoint states and allows the uncertainty of not knowing if resolution has occurred to be easily captured when constructing the likelihood; observations of absent symptoms can be considered to be temporary or having resulted from resolution. The proposed methodology is illustrated on a psoriatic arthritis data set where the outcome of interest is a set of intermittently observed disability scores. Estimated probabilities of resolving are also obtained from the model. © 2016 The Authors. Statistics in Medicine Published by John Wiley & Sons Ltd. © 2016 The Authors. Statistics in Medicine Published by John Wiley & Sons Ltd.

  1. Finite-size scaling for discontinuous nonequilibrium phase transitions

    NASA Astrophysics Data System (ADS)

    de Oliveira, Marcelo M.; da Luz, M. G. E.; Fiore, Carlos E.

    2018-06-01

    A finite-size scaling theory, originally developed only for transitions to absorbing states [Phys. Rev. E 92, 062126 (2015), 10.1103/PhysRevE.92.062126], is extended to distinct sorts of discontinuous nonequilibrium phase transitions. Expressions for quantities such as response functions, reduced cumulants, and equal area probability distributions are derived from phenomenological arguments. Irrespective of system details, all these quantities scale with the volume, establishing the dependence on size. The approach generality is illustrated through the analysis of different models. The present results are a relevant step in trying to unify the scaling behavior description of nonequilibrium transition processes.

  2. A landscape-scale assessment of plant communities, hydrologic processes, and state-and-transition theory in a western juniper dominated ecosystem

    NASA Astrophysics Data System (ADS)

    Petersen, Steven L.

    Western juniper has rapidly expanded into sagebrush steppe communities in the Intermountain West during the past 120 years. This expansion has occurred across a wide range of soil types and topographic positions. These plant communities, however, are typically treated in current peer-reviewed literature generically. The focus of this research is to investigate watershed level response to Western juniper encroachment at multiple topographic positions. Data collected from plots used to measure vegetation, soil moisture, and infiltration rates show that intercanopy sites within encroached Western juniper communities generally exhibit a significant decrease in intercanopy plant density and cover, decreased infiltration rates, increased water sediment content, and lower soil moisture content. High-resolution remotely sensed imagery and Geographic Information Systems were used with these plot level measurements to characterize and model the landscape-scale response for both biotic and abiotic components of a Western juniper encroached ecosystem. These data and their analyses included an inventory of plant density, plant cover, bare ground, gap distance and cover, a plant community classification of intercanopy patches and juniper canopy cover, soil moisture estimation, solar insulation prediction, slope and aspect. From these data, models were built that accurately predicted shrub density and shrub cover throughout the watershed study area, differentiated by aspect. We propose a new model of process-based plant community dynamics associated with current state-and-transition theory. This model is developed from field measurements and spatially explicit information that characterize the relationship between the matrix mountain big sagebrush plant community and intercanopy plant community patterns occurring within a Western juniper dominated woodland at a landscape scale. Model parameters (states, transitions, and thresholds) are developed based on differences in shrub

  3. Studies on Manfred Eigen's model for the self-organization of information processing.

    PubMed

    Ebeling, W; Feistel, R

    2018-05-01

    In 1971, Manfred Eigen extended the principles of Darwinian evolution to chemical processes, from catalytic networks to the emergence of information processing at the molecular level, leading to the emergence of life. In this paper, we investigate some very general characteristics of this scenario, such as the valuation process of phenotypic traits in a high-dimensional fitness landscape, the effect of spatial compartmentation on the valuation, and the self-organized transition from structural to symbolic genetic information of replicating chain molecules. In the first part, we perform an analysis of typical dynamical properties of continuous dynamical models of evolutionary processes. In particular, we study the mapping of genotype to continuous phenotype spaces following the ideas of Wright and Conrad. We investigate typical features of a Schrödinger-like dynamics, the consequences of the high dimensionality, the leading role of saddle points, and Conrad's extra-dimensional bypass. In the last part, we discuss in brief the valuation of compartment models and the self-organized emergence of molecular symbols at the beginning of life.

  4. Motility-Driven Glass and Jamming Transitions in Biological Tissues

    NASA Astrophysics Data System (ADS)

    Bi, Dapeng; Yang, Xingbo; Marchetti, M. Cristina; Manning, M. Lisa

    2016-04-01

    Cell motion inside dense tissues governs many biological processes, including embryonic development and cancer metastasis, and recent experiments suggest that these tissues exhibit collective glassy behavior. To make quantitative predictions about glass transitions in tissues, we study a self-propelled Voronoi model that simultaneously captures polarized cell motility and multibody cell-cell interactions in a confluent tissue, where there are no gaps between cells. We demonstrate that the model exhibits a jamming transition from a solidlike state to a fluidlike state that is controlled by three parameters: the single-cell motile speed, the persistence time of single-cell tracks, and a target shape index that characterizes the competition between cell-cell adhesion and cortical tension. In contrast to traditional particulate glasses, we are able to identify an experimentally accessible structural order parameter that specifies the entire jamming surface as a function of model parameters. We demonstrate that a continuum soft glassy rheology model precisely captures this transition in the limit of small persistence times and explain how it fails in the limit of large persistence times. These results provide a framework for understanding the collective solid-to-liquid transitions that have been observed in embryonic development and cancer progression, which may be associated with epithelial-to-mesenchymal transition in these tissues.

  5. The nature of the continuous non-equilibrium phase transition of Axelrod's model

    NASA Astrophysics Data System (ADS)

    Peres, Lucas R.; Fontanari, José F.

    2015-09-01

    Axelrod's model in the square lattice with nearest-neighbors interactions exhibits culturally homogeneous as well as culturally fragmented absorbing configurations. In the case in which the agents are characterized by F = 2 cultural features and each feature assumes k states drawn from a Poisson distribution of parameter q, these regimes are separated by a continuous transition at qc = 3.10 +/- 0.02 . Using Monte Carlo simulations and finite-size scaling we show that the mean density of cultural domains μ is an order parameter of the model that vanishes as μ ∼ (q - q_c)^β with β = 0.67 +/- 0.01 at the critical point. In addition, for the correlation length critical exponent we find ν = 1.63 +/- 0.04 and for Fisher's exponent, τ = 1.76 +/- 0.01 . This set of critical exponents places the continuous phase transition of Axelrod's model apart from the known universality classes of non-equilibrium lattice models.

  6. Measured Boundary Layer Transition and Rotor Hover Performance at Model Scale

    NASA Technical Reports Server (NTRS)

    Overmeyer, Austin D.; Martin, Preston B.

    2017-01-01

    An experiment involving a Mach-scaled, 11:08 f t: diameter rotor was performed in hover during the summer of 2016 at NASA Langley Research Center. The experiment investigated the hover performance as a function of the laminar to turbulent transition state of the boundary layer, including both natural and fixed transition cases. The boundary layer transition locations were measured on both the upper and lower aerodynamic surfaces simultaneously. The measurements were enabled by recent advances in infrared sensor sensitivity and stability. The infrared thermography measurement technique was enhanced by a paintable blade surface heater, as well as a new high-sensitivity long wave infrared camera. The measured transition locations showed extensive amounts, x=c>0:90, of laminar flow on the lower surface at moderate to high thrust (CT=s > 0:068) for the full blade radius. The upper surface showed large amounts, x=c > 0:50, of laminar flow at the blade tip for low thrust (CT=s < 0:045). The objective of this paper is to provide an experimental data set for comparisons to newly developed and implemented rotor boundary layer transition models in CFD and rotor design tools. The data is expected to be used as part of the AIAA Rotorcraft SimulationWorking Group

  7. Sensitivity study of experimental measures for the nuclear liquid-gas phase transition in the statistical multifragmentation model

    NASA Astrophysics Data System (ADS)

    Lin, W.; Ren, P.; Zheng, H.; Liu, X.; Huang, M.; Wada, R.; Qu, G.

    2018-05-01

    The experimental measures of the multiplicity derivatives—the moment parameters, the bimodal parameter, the fluctuation of maximum fragment charge number (normalized variance of Zmax, or NVZ), the Fisher exponent (τ ), and the Zipf law parameter (ξ )—are examined to search for the liquid-gas phase transition in nuclear multifragmention processes within the framework of the statistical multifragmentation model (SMM). The sensitivities of these measures are studied. All these measures predict a critical signature at or near to the critical point both for the primary and secondary fragments. Among these measures, the total multiplicity derivative and the NVZ provide accurate measures for the critical point from the final cold fragments as well as the primary fragments. The present study will provide a guide for future experiments and analyses in the study of the nuclear liquid-gas phase transition.

  8. Kinetic Analysis for Macrocyclizations Involving Anionic Template at the Transition State

    PubMed Central

    Martí-Centelles, Vicente; Burguete, M. Isabel; Luis, Santiago V.

    2012-01-01

    Several kinetic models for the macrocyclization of a C2 pseudopeptide with a dihalide through a SN2 reaction have been developed. These models not only focus on the kinetic analysis of the main macrocyclization reaction, but also consider the competitive oligomerization/polymerization processes yielding undesired oligomeric/polymeric byproducts. The effect of anions has also been included in the kinetic models, as they can act as catalytic templates in the transition state reducing and stabilizing the transition state. The corresponding differential equation systems for each kinetic model can be solved numerically. Through a comprehensive analysis of these results, it is possible to obtain a better understanding of the different parameters that are involved in the macrocyclization reaction mechanism and to develop strategies for the optimization of the desired processes. PMID:22666148

  9. Hysteresis in the phase transition of chocolate

    NASA Astrophysics Data System (ADS)

    Ren, Ruilong; Lu, Qunfeng; Lin, Sihua; Dong, Xiaoyan; Fu, Hao; Wu, Shaoyi; Wu, Minghe; Teng, Baohua

    2016-01-01

    We designed an experiment to reproduce the hysteresis phenomenon of chocolate appearing in the heating and cooling process, and then established a model to relate the solidification degree to the order parameter. Based on the Landau-Devonshire theory, our model gave a description of the hysteresis phenomenon in chocolate, which lays the foundations for the study of the phase transition behavior of chocolate.

  10. Phase transition approach to bursting in neuronal cultures: quorum percolation models

    NASA Astrophysics Data System (ADS)

    Monceau, P.; Renault, R.; Métens, S.; Bottani, S.; Fardet, T.

    2017-10-01

    The Quorum Percolation model has been designed in the context of neurobiology to describe bursts of activity occurring in neuronal cultures from the point of view of statistical physics rather than from a dynamical synchronization approach. It is based upon information propagation on a directed graph with a threshold activation rule; this leads to a phase diagram which exhibits a giant percolation cluster below some critical value mC of the excitability. We describe the main characteristics of the original model and derive extensions according to additional relevant biological features. Firstly, we investigate the effects of an excitability variability on the phase diagram and show that the percolation transition can be destroyed by a sufficient amount of such a disorder; we stress the weakly averaging character of the order parameter and show that connectivity and excitability can be seen as two overlapping aspects of the same reality. Secondly, we elaborate a discrete time stochastic model taking into account the decay originating from ionic leakage through the membrane of neurons and synaptic depression; we give evidence that the decay softens and shifts the transition, and conjecture than decay destroys the transition in the thermodynamical limit. We were able to develop mean-field theories associated with each of the two effects; we discuss the framework of their agreement with Monte Carlo simulations. It turns out that the the critical point mC from which information on the connectivity of the network can be inferred is affected by each of these additional effects. Lastly, we show how dynamical simulations of bursts with an adaptive exponential integrateand- fire model can be interpreted in terms of Quorum Percolation. Moreover, the usefulness of the percolation model including the set of sophistication we investigated can be extended to many scientific fields involving information propagation, such as the spread of rumors in sociology, ethology, ecology.

  11. Universality of the Berezinskii-Kosterlitz-Thouless type of phase transition in the dipolar XY-model

    NASA Astrophysics Data System (ADS)

    Vasiliev, A. Yu; Tarkhov, A. E.; Menshikov, L. I.; Fedichev, P. O.; Fischer, Uwe R.

    2014-05-01

    We investigate the nature of the phase transition occurring in a planar XY-model spin system with dipole-dipole interactions. It is demonstrated that a Berezinskii-Kosterlitz-Thouless (BKT) type of phase transition always takes place at a finite temperature separating the ordered (ferro) and the disordered (para) phases. The low-temperature phase corresponds to an ordered state with thermal fluctuations, composed of a ‘gas’ of bound vortex-antivortex pairs, which would, when considered isolated, be characterized by a constant vortex-antivortex attraction force which is due to the dipolar interaction term in the Hamiltonian. Using a topological charge model, we show that small bound pairs are easily polarized, and screen the vortex-antivortex interaction in sufficiently large pairs. Screening changes the linear attraction potential of vortices to a logarithmic one, and leads to the familiar pair dissociation mechanism of the BKT type phase transition. The topological charge model is confirmed by numerical simulations, in which we demonstrate that the transition temperature slightly increases when compared with the BKT result for short-range interactions.

  12. Tracking the Growth Transitions of A Solvent-Charged Model Globular Protein

    NASA Astrophysics Data System (ADS)

    Babcock, Jeremiah; Friday, Jacob; Brancaleon, Lorenzo

    2011-03-01

    Biophysical studies have shown that solutes like proteins undergo aggregation through specific pathways that often lead to long polymeric structures called fibrils. The knowledge of the size of early-stage protein aggregates (oligomers) has an important bearing on the elucidation of the dynamics of the process of protein unit combinations. In this study, bovine serum albumin, a well-characterized model protein known to polymerize in alkaline and acidic conditions in the normal (N) to basic (B) or (N) to (E) transition, was incubated at pH 9.0 and pH 3.1 for longer than eight days. Particle growth in solution was monitored by absorption, fluorescence and circular dichroism spectroscopy and concurrently measured by atomic force microscopy (AFM) methods to yield BSA oligomer size distributions. Results show that the BSA aggregation pathway is concentration-dependent and rapidly forms spherical aggregates, which preferentially come together to form flexible polymers.

  13. Bifurcation and Spike Adding Transition in Chay-Keizer Model

    NASA Astrophysics Data System (ADS)

    Lu, Bo; Liu, Shenquan; Liu, Xuanliang; Jiang, Xiaofang; Wang, Xiaohui

    Electrical bursting is an activity which is universal in excitable cells such as neurons and various endocrine cells, and it encodes rich physiological information. As burst delay identifies that the signal integration has reached the threshold at which it can generate an action potential, the number of spikes in a burst may have essential physiological implications, and the transition of bursting in excitable cells is associated with the bifurcation phenomenon closely. In this paper, we focus on the transition of the spike count per burst of the pancreatic β-cells within a mathematical model and bifurcation phenomenon in the Chay-Keizer model, which is utilized to simulate the pancreatic β-cells. By the fast-slow dynamical bifurcation analysis and the bi-parameter bifurcation analysis, the local dynamics of the Chay-Keizer system around the Bogdanov-Takens bifurcation is illustrated. Then the variety of the number of spikes per burst is discussed by changing the settings of a single parameter and bi-parameter. Moreover, results on the number of spikes within a burst are summarized in ISIs (interspike intervals) sequence diagrams, maximum and minimum, and the number of spikes under bi-parameter value changes.

  14. A sea urchin in vivo model to evaluate Epithelial-Mesenchymal Transition.

    PubMed

    Romancino, Daniele P; Anello, Letizia; Lavanco, Antonella; Buffa, Valentina; Di Bernardo, Maria; Bongiovanni, Antonella

    2017-04-01

    Epithelial-mesenchymal transition (EMT) is an evolutionarily conserved cellular program, which is a prerequisite for the metastatic cascade in carcinoma progression. Here, we evaluate the EMT process using the sea urchin Paracentrotus lividus embryo. In sea urchin embryos, the earliest EMT event is related to the acquisition of a mesenchymal phenotype by the spiculogenetic primary mesenchyme cells (PMCs) and their migration into the blastocoel. We investigated the effect of inhibiting the epidermal growth factor (EGF) signaling pathway on this process, and we observed that mesenchyme cell differentiation was blocked. In order to extend and validate our studies, we investigated the migratory capability and the level of potential epidermal growth factor receptor (EGFr) targets in a breast cancer cell line after EGF modulation. Altogether, our data highlight the sensitivity of the sea urchin embryo to anti-EMT drugs and pinpoint the sea urchin embryo as a valuable in vivo model system for studying EMT and the screening of anti-EMT candidates. © 2017 Japanese Society of Developmental Biologists.

  15. Modeling evolution of hydrogen bonding and stabilization of transition states in the process of cocaine hydrolysis catalyzed by human butyrylcholinesterase.

    PubMed

    Gao, Daquan; Zhan, Chang-Guo

    2006-01-01

    Molecular dynamics (MD) simulations and quantum mechanical/molecular mechanical (QM/MM) calculations were performed on the prereactive enzyme-substrate complex, transition states, intermediates, and product involved in the process of human butyrylcholinesterase (BChE)-catalyzed hydrolysis of (-)-cocaine. The computational results consistently reveal a unique role of the oxyanion hole (consisting of G116, G117, and A199) in BChE-catalyzed hydrolysis of cocaine, compared to acetylcholinesterase (AChE)-catalyzed hydrolysis of acetylcholine. During BChE-catalyzed hydrolysis of cocaine, only G117 has a hydrogen bond with the carbonyl oxygen (O31) of the cocaine benzoyl ester in the prereactive BChE-cocaine complex, and the NH groups of G117 and A199 are hydrogen-bonded with O31 of cocaine in all of the transition states and intermediates. Surprisingly, the NH hydrogen of G116 forms an unexpected hydrogen bond with the carboxyl group of E197 side chain and, therefore, is not available to form a hydrogen bond with O31 of cocaine in the acylation. The NH hydrogen of G116 is only partially available to form a weak hydrogen bond with O31 of cocaine in some structures involved in the deacylation. The change of the estimated hydrogen-bonding energy between the oxyanion hole and O31 of cocaine during the reaction process demonstrates how the protein environment can affect the energy barrier for each step of the BChE-catalyzed hydrolysis of cocaine. These insights concerning the effects of the oxyanion hole on the energy barriers provide valuable clues on how to rationally design BChE mutants with a higher catalytic activity for the hydrolysis of (-)-cocaine. 2005 Wiley-Liss, Inc.

  16. Modeling Evolution of Hydrogen Bonding and Stabilization of Transition States in the Process of Cocaine Hydrolysis Catalyzed by Human Butyrylcholinesterase

    PubMed Central

    Gao, Daquan; Zhan, Chang-Guo

    2010-01-01

    Molecular dynamics (MD) simulations and quantum mechanical/molecular mechanical (QM/MM) calculations were performed on the prereactive enzyme-substrate complex, transition states, intermediates, and product involved in the process of human butyrylcholinesterase (BChE)-catalyzed hydrolysis of (−)-cocaine. The computational results consistently reveal a unique role of the oxyanion hole (consisting of G116, G117, and A199) in BChE-catalyzed hydrolysis of cocaine, as compared to acetylcholinesterase (AChE)-catalyzed hydrolysis of acetylcholine. During BChE-catalyzed hydrolysis of cocaine, only G117 has a hydrogen bond with the carbonyl oxygen (O31) of the cocaine benzoyl ester in the prereactive BChE-cocaine complex, and the NH groups of G117 and A199 are hydrogen-bonded with O31 of cocaine in all of the transition states and intermediates. Surprisingly, the NH hydrogen of G116 forms an unexpected hydrogen bond with the carboxyl group of E197 side chain and, therefore, is not available to form a hydrogen bond with O31 of cocaine in the acylation. The NH hydrogen of G116 is only partially available to form a weak hydrogen bond with O31 of cocaine in some structures involved in the deacylation. The change of the estimated hydrogen bonding energy between the oxyanion hole and O31 of cocaine during the reaction process demonstrates how the protein environment can affect the energy barrier for each step of the BChE-catalyzed hydrolysis of cocaine. These insights concerning the effects of the oxyanion hole on the energy barriers provide valuable clues on how to rationally design BChE mutants with a higher catalytic activity for the hydrolysis of (−)-cocaine. PMID:16288482

  17. Process Correlation Analysis Model for Process Improvement Identification

    PubMed Central

    Park, Sooyong

    2014-01-01

    Software process improvement aims at improving the development process of software systems. It is initiated by process assessment identifying strengths and weaknesses and based on the findings, improvement plans are developed. In general, a process reference model (e.g., CMMI) is used throughout the process of software process improvement as the base. CMMI defines a set of process areas involved in software development and what to be carried out in process areas in terms of goals and practices. Process areas and their elements (goals and practices) are often correlated due to the iterative nature of software development process. However, in the current practice, correlations of process elements are often overlooked in the development of an improvement plan, which diminishes the efficiency of the plan. This is mainly attributed to significant efforts and the lack of required expertise. In this paper, we present a process correlation analysis model that helps identify correlations of process elements from the results of process assessment. This model is defined based on CMMI and empirical data of improvement practices. We evaluate the model using industrial data. PMID:24977170

  18. Process correlation analysis model for process improvement identification.

    PubMed

    Choi, Su-jin; Kim, Dae-Kyoo; Park, Sooyong

    2014-01-01

    Software process improvement aims at improving the development process of software systems. It is initiated by process assessment identifying strengths and weaknesses and based on the findings, improvement plans are developed. In general, a process reference model (e.g., CMMI) is used throughout the process of software process improvement as the base. CMMI defines a set of process areas involved in software development and what to be carried out in process areas in terms of goals and practices. Process areas and their elements (goals and practices) are often correlated due to the iterative nature of software development process. However, in the current practice, correlations of process elements are often overlooked in the development of an improvement plan, which diminishes the efficiency of the plan. This is mainly attributed to significant efforts and the lack of required expertise. In this paper, we present a process correlation analysis model that helps identify correlations of process elements from the results of process assessment. This model is defined based on CMMI and empirical data of improvement practices. We evaluate the model using industrial data.

  19. Ignition, Transition, Flame Spread in Multidimensional Configurations in Microgravity

    NASA Technical Reports Server (NTRS)

    Kashiwagi, Takashi; Mell, William E.; McGrattan, Kevin B.; Baum, Howard R.; Olson, Sandra L.; Fujita, Osamu; Kikuchi, Masao; Ito, Kenichi

    1997-01-01

    Ignition of solid fuels by external thermal radiation and subsequent transition to flame spread are processes that not only are of considerable scientific interest but which also have fire safety applications. A material which undergoes a momentary ignition might be tolerable but a material which permits a transition to subsequent flame spread would significantly increase the fire hazard in a spacecraft. Therefore, the limiting condition under which flame cannot spread should be calculated from a model of the transition from ignition instead of by the traditional approach based on limits to a steady flame spread model. However, although the fundamental processes involved in ignition have been suggested there have been no definitive experimental or modeling studies due to the flow motion generated by buoyancy near the heated sample surface. In this study, microgravity experiments which required longer test times such as in air and surface smoldering experiment were conducted in the space shuttle STS-75 flight; shorter experimental tests such as in 35% and 50% oxygen were conducted in the droptower in the Japan Microgravity Center, JAMIC. Their experimental data along with theoretically calculated results from solving numerically the time-dependent Navier-Stokes equations are summarized in this paper.

  20. Long-Time Variation of Magnetic Structure in (Pr xLa 1-x)Co 2Si 2: Coexistence of Slow and Fast Processes in Magnetic Phase Transition

    DOE PAGES

    Motoya, Kiyoichiro; Hagihala, Masato; Shigeoka, Toru; ...

    2017-03-14

    In this paper, long-time variations of the magnetic structure in PrCo 2Si 2 and (Pr 0.98La 0.02)Co 2Si 2 were studied by magnetization and time-resolved neutron scattering measurements. The amplitudes of magnetic Bragg peaks showed marked time variations after cooling or heating across the magnetic transition temperature T 1 between two different antiferromagnetic phases. However, the amplitude of the time variation decreased rapidly with increasing distance from T 1. Finally, we analyzed the results on the basis of a phase transition model that includes the coexistence of fast and slow processes.