Science.gov

Sample records for pseudorotating molecular top

  1. Pseudorotation in fullerene anions

    NASA Astrophysics Data System (ADS)

    Dunn, Janette L.; Hands, Ian D.; Bates, Colin A.

    2007-07-01

    Jahn-Teller (JT) problems are often characterised by an adiabatic potential energy surface (APES) containing either a set of isoenergetic wells or a trough of equivalent-energy points, which may be warped by higher-order coupling terms or anisotropic effects. In all three cases, the JT effect will be dynamic. Either tunnelling between the wells or rotation (of a distortion) around the trough will restore the original symmetry of the system. This motion is referred to as pseudorotation. It should be possible to observe a JT system in a distorted geometry if measurements are made on a sufficiently short timescale. In various cubic systems, this timescale has been calculated to be the order of picoseconds. Such timescales are accessible using modern methods of ultrafast spectroscopy. Measurements of pseudorotation rates can lead to important information on the strength and nature of the JT coupling present. We will present analytical calculations that allow the rate of pseudorotation to be determined in terms of the vibronic coupling parameters. We will show how these results can be applied to E ⊗ e systems and then to the more complicated system applicable to C60- anions. This is of particular interest because of the high icosahedral symmetry of fullerene ions and also because of the many potential uses of materials containing these ions. We conclude by outlining experiments that should be capable of measuring pseudorotation in C 60 anions.

  2. Top 10 plant viruses in molecular plant pathology.

    PubMed

    Scholthof, Karen-Beth G; Adkins, Scott; Czosnek, Henryk; Palukaitis, Peter; Jacquot, Emmanuel; Hohn, Thomas; Hohn, Barbara; Saunders, Keith; Candresse, Thierry; Ahlquist, Paul; Hemenway, Cynthia; Foster, Gary D

    2011-12-01

    Many scientists, if not all, feel that their particular plant virus should appear in any list of the most important plant viruses. However, to our knowledge, no such list exists. The aim of this review was to survey all plant virologists with an association with Molecular Plant Pathology and ask them to nominate which plant viruses they would place in a 'Top 10' based on scientific/economic importance. The survey generated more than 250 votes from the international community, and allowed the generation of a Top 10 plant virus list for Molecular Plant Pathology. The Top 10 list includes, in rank order, (1) Tobacco mosaic virus, (2) Tomato spotted wilt virus, (3) Tomato yellow leaf curl virus, (4) Cucumber mosaic virus, (5) Potato virus Y, (6) Cauliflower mosaic virus, (7) African cassava mosaic virus, (8) Plum pox virus, (9) Brome mosaic virus and (10) Potato virus X, with honourable mentions for viruses just missing out on the Top 10, including Citrus tristeza virus, Barley yellow dwarf virus, Potato leafroll virus and Tomato bushy stunt virus. This review article presents a short review on each virus of the Top 10 list and its importance, with the intent of initiating discussion and debate amongst the plant virology community, as well as laying down a benchmark, as it will be interesting to see in future years how perceptions change and which viruses enter and leave the Top 10. PMID:22017770

  3. The Top 10 fungal pathogens in molecular plant pathology.

    PubMed

    Dean, Ralph; Van Kan, Jan A L; Pretorius, Zacharias A; Hammond-Kosack, Kim E; Di Pietro, Antonio; Spanu, Pietro D; Rudd, Jason J; Dickman, Marty; Kahmann, Regine; Ellis, Jeff; Foster, Gary D

    2012-05-01

    The aim of this review was to survey all fungal pathologists with an association with the journal Molecular Plant Pathology and ask them to nominate which fungal pathogens they would place in a 'Top 10' based on scientific/economic importance. The survey generated 495 votes from the international community, and resulted in the generation of a Top 10 fungal plant pathogen list for Molecular Plant Pathology. The Top 10 list includes, in rank order, (1) Magnaporthe oryzae; (2) Botrytis cinerea; (3) Puccinia spp.; (4) Fusarium graminearum; (5) Fusarium oxysporum; (6) Blumeria graminis; (7) Mycosphaerella graminicola; (8) Colletotrichum spp.; (9) Ustilago maydis; (10) Melampsora lini, with honourable mentions for fungi just missing out on the Top 10, including Phakopsora pachyrhizi and Rhizoctonia solani. This article presents a short resumé of each fungus in the Top 10 list and its importance, with the intent of initiating discussion and debate amongst the plant mycology community, as well as laying down a bench-mark. It will be interesting to see in future years how perceptions change and what fungi will comprise any future Top 10. PMID:22471698

  4. Top 10 plant pathogenic bacteria in molecular plant pathology.

    PubMed

    Mansfield, John; Genin, Stephane; Magori, Shimpei; Citovsky, Vitaly; Sriariyanum, Malinee; Ronald, Pamela; Dow, Max; Verdier, Valérie; Beer, Steven V; Machado, Marcos A; Toth, Ian; Salmond, George; Foster, Gary D

    2012-08-01

    Many plant bacteriologists, if not all, feel that their particular microbe should appear in any list of the most important bacterial plant pathogens. However, to our knowledge, no such list exists. The aim of this review was to survey all bacterial pathologists with an association with the journal Molecular Plant Pathology and ask them to nominate the bacterial pathogens they would place in a 'Top 10' based on scientific/economic importance. The survey generated 458 votes from the international community, and allowed the construction of a Top 10 bacterial plant pathogen list. The list includes, in rank order: (1) Pseudomonas syringae pathovars; (2) Ralstonia solanacearum; (3) Agrobacterium tumefaciens; (4) Xanthomonas oryzae pv. oryzae; (5) Xanthomonas campestris pathovars; (6) Xanthomonas axonopodis pathovars; (7) Erwinia amylovora; (8) Xylella fastidiosa; (9) Dickeya (dadantii and solani); (10) Pectobacterium carotovorum (and Pectobacterium atrosepticum). Bacteria garnering honourable mentions for just missing out on the Top 10 include Clavibacter michiganensis (michiganensis and sepedonicus), Pseudomonas savastanoi and Candidatus Liberibacter asiaticus. This review article presents a short section on each bacterium in the Top 10 list and its importance, with the intention of initiating discussion and debate amongst the plant bacteriology community, as well as laying down a benchmark. It will be interesting to see, in future years, how perceptions change and which bacterial pathogens enter and leave the Top 10. PMID:22672649

  5. Understanding the molecular properties and metabolism of top prescribed drugs.

    PubMed

    Zhong, Haizhen A; Mashinson, Victoria; Woolman, Theodor A; Zha, Mengyi

    2013-01-01

    Molecular properties such as the molecular weight, hydrophobicity parameter logP, and the total polar surface area (TPSA) have been used extensively in modern drug discovery. We investigated these properties and ADMET scores of the top 200 therapeutic drugs by the U.S. retail sales (2010) and classified them according to the clinical indications and/or routes of administration. This list of drugs provides ample information of these molecular descriptors for successfully approved drugs. The mean logP for oral drugs is 2.5 while the logP for injectable drugs seems to be smaller. Among different types of clinical indications, drugs used for anti-HIV, and antibiotics tend to have lower logP. The molecular weights of anti-HIV drugs, antihypertensives and antibiotics appear to be larger. The ADMET scores, derived from a combination of molecular weights and logP, are consistent for oral drugs, with a mean score of 1.5 and a standard deviation of 1.0. Many clinical drugs that violate Lipinski's rule of five criteria can still exhibit ADMET scores that are very close to the mean value for oral drugs (1.5) and lie within the acceptable standard deviation. The molecular properties of MW, logP, and TPSA appear to vary according to their clinical indications. Many drugs form salts or cocrystals with acids or solvents that increase their solubility. Our data show that addition of hydrochloride is the most common method to increase solubility of drug ingredients. Cytochrome P450 isozymes 3A4, 2D6, 2C9, 2C8 and 3C5 are the top five proteins that metabolize the 200 most prescribed drugs. Drugs metabolized by 3A4 appear to have larger molecular weights and those metabolized by 2D6 have lower molecular weights. CYP2C8-metabolized drugs appear to be most hydrophilic, with the smallest logP and the largest polar surface areas. PMID:23675936

  6. Top 10 Plant Viruses in Molecular Plant Pathology

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Scientific and economic importance were used to rank plant viruses to indicate the Top 10. Each virus is discussed to open debate and conversation within and beyond the plant virology community as new pathogens come and go in importance....

  7. Breaking Pseudo-Rotational Symmetry through H_+^2 Metric Deformation in the Eckart Potential Problem

    NASA Astrophysics Data System (ADS)

    Leija-Martinez, Nehemias; Alvarez-Castillo, David Edwin; Kirchbach, Mariana

    2011-12-01

    The peculiarity of the Eckart potential problem on H+2 (the upper sheet of the two-sheeted two-dimensional hyperboloid), to preserve the (2l+1)-fold degeneracy of the states typical for the geodesic motion there, is usually explained in casting the respective Hamiltonian in terms of the Casimir invariant of an so(2,1) algebra, referred to as potential algebra. In general, there are many possible similarity transformations of the symmetry algebras of the free motions on curved surfaces towards potential algebras, which are not all necessarily unitary. In the literature, a transformation of the symmetry algebra of the geodesic motion on H+2 towards the potential algebra of Eckart's Hamiltonian has been constructed for the prime purpose to prove that the Eckart interaction belongs to the class of Natanzon potentials. We here take a different path and search for a transformation which connects the (2l+1) dimensional representation space of the pseudo-rotational so(2,1) algebra, spanned by the rank-l pseudo-spherical harmonics, to the representation space of equal dimension of the potential algebra and find a transformation of the scaling type. Our case is that in so doing one is producing a deformed isometry copy to H+2 such that the free motion on the copy is equivalent to a motion on H+2, perturbed by a coth interaction. In this way, we link the so(2,1) potential algebra concept of the Eckart Hamiltonian to a subtle type of pseudo-rotational symmetry breaking through H+2 metric deformation. From a technical point of view, the results reported here are obtained by virtue of certain nonlinear finite expansions of Jacobi polynomials into pseudo-spherical harmonics. In due places, the pseudo-rotational case is paralleled by its so(3) compact analogue, the cotangent perturbed motion on S2. We expect awareness of different so(2,1)/so(3) isomet ry copies to benefit simulation studies on curved manifolds of many-body systems.

  8. Pseudorotational epitaxy of self-assembled octadecyltrichlorosilane monolayers on sapphire (0001)

    DOE PAGESBeta

    Steinrück, H. -G.; Magerl, A.; Deutsch, M.; Ocko, B. M.

    2014-10-06

    The structure of octadecyltrichlorosilane self-assembled monolayers (SAMs) on sapphire (0001) was studied by Å-resolution surface-specific x-ray scattering methods. The monolayer was found to consist of three sublayers where the outermost layer corresponds to vertically oriented, closely packed alkyl tails. Laterally, the monolayer is hexagonally packed and exhibits pseudorotational epitaxy to the sapphire, manifested by a broad scattering peak at zero relative azimuthal rotation, with long powderlike tails. The lattice mismatch of ~1% – 3% to the sapphire’s and the different length scale introduced by the lateral Si-O-Si bonding prohibit positional epitaxy. However, the substrate induces an intriguing increase in themore » crystalline coherence length of the SAM’s powderlike crystallites when rotationally aligned with the sapphire’s lattice. As a result, the increase correlates well with the rotational dependence of the separation of corresponding substrate-monolayer lattice sites.« less

  9. Pseudorotational epitaxy of self-assembled octadecyltrichlorosilane monolayers on sapphire (0001)

    SciTech Connect

    Steinrück, H. -G.; Magerl, A.; Deutsch, M.; Ocko, B. M.

    2014-10-06

    The structure of octadecyltrichlorosilane self-assembled monolayers (SAMs) on sapphire (0001) was studied by Å-resolution surface-specific x-ray scattering methods. The monolayer was found to consist of three sublayers where the outermost layer corresponds to vertically oriented, closely packed alkyl tails. Laterally, the monolayer is hexagonally packed and exhibits pseudorotational epitaxy to the sapphire, manifested by a broad scattering peak at zero relative azimuthal rotation, with long powderlike tails. The lattice mismatch of ~1% – 3% to the sapphire’s and the different length scale introduced by the lateral Si-O-Si bonding prohibit positional epitaxy. However, the substrate induces an intriguing increase in the crystalline coherence length of the SAM’s powderlike crystallites when rotationally aligned with the sapphire’s lattice. As a result, the increase correlates well with the rotational dependence of the separation of corresponding substrate-monolayer lattice sites.

  10. Top 10 plant-parasitic nematodes in molecular plant pathology.

    PubMed

    Jones, John T; Haegeman, Annelies; Danchin, Etienne G J; Gaur, Hari S; Helder, Johannes; Jones, Michael G K; Kikuchi, Taisei; Manzanilla-López, Rosa; Palomares-Rius, Juan E; Wesemael, Wim M L; Perry, Roland N

    2013-12-01

    The aim of this review was to undertake a survey of researchers working with plant-parasitic nematodes in order to determine a 'top 10' list of these pathogens based on scientific and economic importance. Any such list will not be definitive as economic importance will vary depending on the region of the world in which a researcher is based. However, care was taken to include researchers from as many parts of the world as possible when carrying out the survey. The top 10 list emerging from the survey is composed of: (1) root-knot nematodes (Meloidogyne spp.); (2) cyst nematodes (Heterodera and Globodera spp.); (3) root lesion nematodes (Pratylenchus spp.); (4) the burrowing nematode Radopholus similis; (5) Ditylenchus dipsaci; (6) the pine wilt nematode Bursaphelenchus xylophilus; (7) the reniform nematode Rotylenchulus reniformis; (8) Xiphinema index (the only virus vector nematode to make the list); (9) Nacobbus aberrans; and (10) Aphelenchoides besseyi. The biology of each nematode (or nematode group) is reviewed briefly. PMID:23809086

  11. The Top 10 oomycete pathogens in molecular plant pathology.

    PubMed

    Kamoun, Sophien; Furzer, Oliver; Jones, Jonathan D G; Judelson, Howard S; Ali, Gul Shad; Dalio, Ronaldo J D; Roy, Sanjoy Guha; Schena, Leonardo; Zambounis, Antonios; Panabières, Franck; Cahill, David; Ruocco, Michelina; Figueiredo, Andreia; Chen, Xiao-Ren; Hulvey, Jon; Stam, Remco; Lamour, Kurt; Gijzen, Mark; Tyler, Brett M; Grünwald, Niklaus J; Mukhtar, M Shahid; Tomé, Daniel F A; Tör, Mahmut; Van Den Ackerveken, Guido; McDowell, John; Daayf, Fouad; Fry, William E; Lindqvist-Kreuze, Hannele; Meijer, Harold J G; Petre, Benjamin; Ristaino, Jean; Yoshida, Kentaro; Birch, Paul R J; Govers, Francine

    2015-05-01

    Oomycetes form a deep lineage of eukaryotic organisms that includes a large number of plant pathogens which threaten natural and managed ecosystems. We undertook a survey to query the community for their ranking of plant-pathogenic oomycete species based on scientific and economic importance. In total, we received 263 votes from 62 scientists in 15 countries for a total of 33 species. The Top 10 species and their ranking are: (1) Phytophthora infestans; (2, tied) Hyaloperonospora arabidopsidis; (2, tied) Phytophthora ramorum; (4) Phytophthora sojae; (5) Phytophthora capsici; (6) Plasmopara viticola; (7) Phytophthora cinnamomi; (8, tied) Phytophthora parasitica; (8, tied) Pythium ultimum; and (10) Albugo candida. This article provides an introduction to these 10 taxa and a snapshot of current research. We hope that the list will serve as a benchmark for future trends in oomycete research. PMID:25178392

  12. Field-free molecular alignment of asymmetric top molecules using elliptically polarized laser pulses

    NASA Astrophysics Data System (ADS)

    Rouzée, A.; Guérin, S.; Faucher, O.; Lavorel, B.

    2008-04-01

    We show theoretically that a short specific elliptically polarized laser pulse driving an asymmetric top molecule can induce postpulse revivals of three-dimensional (3D) alignment. By choosing the field ellipticity resulting in the best compromise between the alignment of two molecular axes, we demonstrate that efficient 3D alignment can be achieved at low temperature. In the experiment, the field-free alignment of moderately cool ethylene molecules is probed by using a technique based on the optical Kerr effect. Control of 3D field-free alignment opens the door to a large range of applications in chemistry as well as in molecular optics.

  13. Pseudorotational landscape of seven-membered rings: the most stable chair and twist-boat conformers of ε-caprolactone.

    PubMed

    Jahn, Michaela K; Dewald, David A; Vallejo-López, Montserrat; Cocinero, Emilio J; Lesarri, Alberto; Zou, Wenli; Cremer, Dieter; Grabow, Jens-Uwe

    2014-10-20

    The conformational landscape and ring-puckering properties of ε-caprolactone have been analyzed by using microwave spectroscopy and quantum chemical calculations. Two conformers were detected in a supersonic jet expansion, the most stable form being a chair containing the ester group in its rectangular flap. This conformation benefits from reduced CH2 bond eclipsing and angle strain, while π-electron delocalization in the ester group is increased. The derived effective structure of the chair form satisfactorily agrees with the calculated near-equilibrium structure. A twist-boat conformer was also identified (9.4 kJ mol(-1) higher in energy at CCSD(T)/aug-cc-pVTZ level), and was located in the boat-twist-boat pseudorotation cycle of the seven-membered ring. Three other low-energy conformers were investigated and characterized in terms of the four puckering coordinates of the seven-membered ring. Potential interconversions in the four-dimensional conformation space are also discussed. PMID:25196306

  14. Molecular Layer-seeded Ultra-thin Top-gate Dielectrics for High Transconductance Graphene Transistors

    NASA Astrophysics Data System (ADS)

    Sangwan, Vinod; Jariwala, Deep; Karmel, Hunter; Alaboson, Justice; Lauhon, Lincoln; Marks, Tobin; Hersam, Mark

    2012-02-01

    The potential of graphene in integrated analog and digital circuits can only be fully realized through incorporation of ultra-thin gate dielectrics to enable large-scale small-channel graphene field-effect transistors (GFETs). Atomic-layer deposition (ALD) is a viable technique to fabricate gate-dielectrics, however, it requires a seeding layer on otherwise inert graphene. Here, we demonstrate a single molecule thick perylene-3,4,9,10-tetracarboxylic dianhydride overlayer as an effective seeding layer to grow high-κ Al2O3 on mechanically exfoliated graphene for high-performance GFETs. Using an ultra-thin (< 1nm) seeding layer, in contrast to polymer films (5-10 nm), we demonstrate fabrication of the thinnest ALD-grown gate-dielectric (4 nm) reported to date in top-gated GFETs. This yields high performance GFETs with the intrinsic transconductance parameter approaching 2.4 mS and the field-effect mobility ˜3000 cm^2/Vs. We also demonstrate generalization of this molecular layer seeded-ALD growth method to higher- κ gate dielectrics, yielding further enhanced GFET transconductance for possible application to radio-frequency circuits.

  15. Molecular collisions. 11: Semiclassical approximation to atom-symmetric top rotational excitation

    NASA Technical Reports Server (NTRS)

    Russell, D.; Curtiss, C. F.

    1973-01-01

    In a paper of this series a distorted wave approximation to the T matrix for atom-symmetric top scattering was developed which is correct to first order in the part of the interaction potential responsible for transitions in the component of rotational angular momentum along the symmetry axis of the top. A semiclassical expression for this T matrix is derived by assuming large values of orbital and rotational angular momentum quantum numbers.

  16. Molecular collisions 21: Semiclassical approximation to atom-symmetric top rotational excitation

    NASA Technical Reports Server (NTRS)

    Russell, D.; Curtiss, C. F.

    1973-01-01

    A distorted wave approximation to the T matrix for atom-symmetric top scattering was developed. The approximation is correct to first order in the part of the interaction potential responsible for transitions in the component of rotational angular momentum along the symmetry axis of the top. A semiclassical expression for this T matrix is derived by assuming large values of orbital and rotational angular momentum quantum numbers.

  17. Zinc(II) and cadmium(II) monohydroxide bridged, dinuclear metallacycles: a unique case of concerted double Berry pseudorotation.

    PubMed

    Reger, Daniel L; Pascui, Andrea E; Pellechia, Perry J; Smith, Mark D

    2013-10-01

    The reactions of M(ClO4)2·6H2O [M = Zn(II), Cd(II)] and the ligands m-bis[bis(1-pyrazolyl)methyl]benzene, L(m), or m-bis[bis(3,5-dimethyl-1-pyrazolyl)methyl]benzene, L(m)*, in the presence of a base yield the hydroxide bridged dinuclear metallacycles [M2(μ-OH)(μ-L)2](ClO4)3, L = L(m), M = Zn(II) (1); L = L(m)*, M = Zn(II) (2), Cd(II) (3). In the solid state, the coordination environment of the metals is distorted trigonal bipyramidal with the bridging hydroxide in an equatorial position and M-O-M angles greater than 161°. The observation of two equal intensity resonances for each type of pyrazolyl-ring hydrogen in the (1)H NMR for all three complexes coupled with the determination of the hydrodynamic radius based on the diffusion coefficient of 1 that matches that observed in the crystal structure, demonstrate this structure is retained in solution. Additional proof of the dinuclear structures in solution is given by the (113)Cd NMR spectrum of [Cd2(μ-OH)(μ-L(m)*)2](ClO4)3 showing (111/113)Cd satellites (J(111)(Cd-)(113)(Cd) = 173 Hz). Complex 1 is dynamic in solution, with the resonances for each type of pyrazolyl-ring hydrogen broadening and averaging at higher temperatures. Detailed variable temperature studies show that ΔG(pz)(‡) = 15.2(±0.2) kcal/mol, ΔH(pz)(‡) = 6.6(±0.1) kcal/mol, and ΔS(pz)(‡) = -28.8(±0.4) cal/mol·K at 25 °C for this process. The same ΔG(‡) value for the dynamic process was also determined by saturation transfer experiments. The most plausible mechanism for this dynamic process, which exchanges the axial and equatorial positions of the pyrazolyl rings in the trigonal bipyramidal arrangement, involves Berry pseudorotation at both metal sites using the bridging oxygen atom as the pivot ligand, coupled with the ring flip of the ligand's phenylene spacer by 180°, a rearrangement process we termed the "Columbia Twist and Flip". This process was shown to be influenced by trace amounts of water in the solvent, with a

  18. Molecular Characterization of Geographically Different Banana bunchy top virus Isolates in India.

    PubMed

    Selvarajan, R; Mary Sheeba, M; Balasubramanian, V; Rajmohan, R; Dhevi, N Lakshmi; Sasireka, T

    2010-10-01

    Banana bunchy top disease (BBTD) caused by Banana bunchy top virus (BBTV) is one of the most devastating diseases of banana and poses a serious threat for cultivars like Hill Banana (Syn: Virupakshi) and Grand Naine in India. In this study, we have cloned and sequenced the complete genome comprised of six DNA components of BBTV infecting Hill Banana grown in lower Pulney hills, Tamil Nadu State, India. The complete genome sequence of this hill banana isolate showed high degree of similarity with the corresponding sequences of BBTV isolates originating from Lucknow, Uttar Pradesh State, India, and from Fiji, Egypt, Pakistan, and Australia. In addition, sixteen coat protein (CP) and thirteen replicase genes (Rep) sequences of BBTV isolates collected from different banana growing states of India were cloned and sequenced. The replicase sequences of 13 isolates showed high degree of similarity with that of South Pacific group of BBTV isolates. However, the CP gene of BBTV isolates from Shervroy and Kodaikanal hills of Tamil Nadu showed higher amino acid sequence variability compared to other isolates. Another hill banana isolate from Meghalaya state had 23 nucleotide substitutions in the CP gene but the amino acid sequence was conserved. This is the first report of the characterization of a complete genome of BBTV occurring in the high altitudes of India. Our study revealed that the Indian BBTV isolates with distinct geographical origins belongs to the South Pacific group, except Shervroy and Kodaikanal hill isolates which neither belong to the South Pacific nor the Asian group. PMID:23637489

  19. Inhibition of DNA Topoisomerase Type IIα (TOP2A) by Mitoxantrone and Its Halogenated Derivatives: A Combined Density Functional and Molecular Docking Study

    PubMed Central

    Abu Saleh, Md.; Solayman, Md.; Hoque, Mohammad Mazharol; Khan, Mohammad A. K.; Sarwar, Mohammed G.; Halim, Mohammad A.

    2016-01-01

    In this study, mitoxantrone and its halogenated derivatives have been designed by density functional theory (DFT) to explore their structural and thermodynamical properties. The performance of these drugs was also evaluated to inhibit DNA topoisomerase type IIα (TOP2A) by molecular docking calculation. Noncovalent interactions play significant role in improving the performance of halogenated drugs. The combined quantum and molecular mechanics calculations revealed that CF3 containing drug shows better preference in inhibiting the TOP2A compared to other modified drugs. PMID:27088089

  20. Role of Topoisomerases in Pediatric High Grade Osteosarcomas: TOP2A Gene Is One of the Unique Molecular Biomarkers of Chemoresponse

    PubMed Central

    Nguyen, Aurelia; Lasthaus, Christelle; Guerin, Eric; Marcellin, Luc; Pencreach, Erwan; Gaub, Marie-Pierre; Guenot, Dominique; Entz-Werle, Natacha

    2013-01-01

    Currently, the treatment of pediatric high-grade osteosarcomas systematically includes one topoisomerase IIα inhibitor. This chemotherapy is usually adapted to the response to the neo-adjuvant therapy after surgery. The current and unique marker of chemoresponsiveness is the percentage of viable residual cells in the surgical resection. This late patient management marker has to be evaluated earlier in the therapeutic history of the patients on initial biopsy. Therefore, new biomarkers, especially those involved in the topoisomerase IIα inhibitor response might be good candidates. Therefore, our study was designed to target TOP1, TOP2A and TOP2B genes in 105 fresh-frozen diagnostic biopsies by allelotyping and real-time quantitative PCR. Our analyses in those pediatric osteosarcomas, homogeneously treated, highlighted the frequent involvement of topo-isomerase genes. The main and most important observation was the statistical link between the presence of TOP2A amplification and the good response to neo-adjuvant chemotherapy. Compared to adult cancers, the 17q21 amplicon, including TOP2A and ERBB2 genes, seems to be differentially implicated in the osteosarcoma chemoresponsiveness. Surprisingly, there is no ERBB2 gene co-amplification and the patients harboring TOP2A amplification tend to show a worse survival, so TOP2A analyses remain a preliminary, but a good molecular approach for the evaluation at diagnosis of pediatric osteosarcoma chemoresponsiveness. PMID:24216996

  1. Topological sub-structural molecular design (TOPS-MODE): a useful tool to explore key fragments of human A3 adenosine receptor ligands.

    PubMed

    Saíz-Urra, Liane; Teijeira, Marta; Rivero-Buceta, Virginia; Helguera, Aliuska Morales; Celeiro, Maria; Terán, Ma Carmen; Besada, Pedro; Borges, Fernanda

    2016-02-01

    Adenosine regulates tissue function by activating four G-protein-coupled adenosine receptors (ARs). Selective agonists and antagonists for A3 ARs have been investigated for the treatment of a variety of immune disorders, cancer, brain, and heart ischemic conditions. We herein present a QSAR study based on a Topological sub-structural molecular design (TOPS-MODE) approach, intended to predict the A3 ARs of a diverse dataset of 124 (94 training set/ 30 prediction set) adenosine derivatives. The final model showed good fit and predictive capability, displaying 85.1 % of the experimental variance. The TOPS-MODE approach afforded a better understanding and interpretation of the developed model based on the useful information extracted from the analysis of the contribution of different molecular fragments to the affinity. PMID:26205409

  2. Molecular basis of the structural stability of a Top7-based scaffold at extreme pH and temperature conditions.

    PubMed

    Soares, Thereza A; Boschek, Curt B; Apiyo, David; Baird, Cheryl; Straatsma, T P

    2010-06-01

    The development of stable biomolecular scaffolds that can tolerate environmental extremes has considerable potential for industrial and defense-related applications. However, most natural proteins are not sufficiently stable to withstand non-physiological conditions. We have recently engineered the de novo designed Top7 protein to specifically recognize the glycoprotein CD4 by insertion of an eight-residue loop. The engineered variant exhibited remarkable stability under chemical and thermal denaturation conditions. In the present study, far-UV CD spectroscopy and explicit-solvent MD simulations are used to investigate the structural stability of Top7 and the engineered variant under extreme conditions of temperature and pH. Circular dichroism measurements suggest that the engineered variant Top7(CB1), like Top7, retains its structure at high temperatures. Changes in CD spectra suggest that there are minor structural rearrangements between neutral and acidic environments for both proteins but that these do not make the proteins less stable at high temperatures. The anti-parallel beta-sheet is well conserved within the timescale simulated whereas there is a decrease of helical content when low pH and high-temperature conditions are combined. Concerted alanine mutations along the alpha-helices of the engineered Top7 variant did not revert this trend when at pH 2 and 400K. The structural resilience of the anti-parallel beta-sheet suggests that the protein scaffold can accommodate varying sequences. The robustness of the Top7 scaffold under extreme conditions of pH and temperature and its amenability to production in inexpensive bacterial expression systems reveal great potential for novel biotechnological applications. PMID:20185346

  3. Formation of hydroxyl-functionalized stilbenoid molecular sieves at the liquid/solid interface on top of a 1-decanol monolayer

    NASA Astrophysics Data System (ADS)

    Bellec, Amandine; Arrigoni, Claire; Douillard, Ludovic; Fiorini-Debuisschert, Céline; Mathevet, Fabrice; Kreher, David; Attias, André-Jean; Charra, Fabrice

    2014-10-01

    Specific molecular tectons can be designed to form molecular sieves through self-assembly at the solid-liquid interface. After demonstrating a model tecton bearing apolar alkyl chains, we then focus on a modified structure involving asymmetric functionalization of some alkyl chains with polar hydroxyl groups in order to get chemical selectivity in the sieving. As the formation of supramolecular self-assembled networks strongly depends on molecule-molecule, molecule-substrate and molecule-solvent interactions, we compared the tectons’ self-assembly on graphite for two types of solvent. We demonstrate the possibility to create hydroxylated stilbenoid molecular sieves by using 1-decanol as a solvent. Interestingly, with this solvent, the porous network is developed on top of a 1-decanol monolayer.

  4. Molecular characterization of banana bunchy top virus isolate from Sri Lanka and its genetic relationship with other isolates.

    PubMed

    Wickramaarachchi, W A R T; Shankarappa, K S; Rangaswamy, K T; Maruthi, M N; Rajapakse, R G A S; Ghosh, Saptarshi

    2016-06-01

    Bunchy top disease of banana caused by Banana bunchy top virus (BBTV, genus Babuvirus family Nanoviridae) is one of the most important constraints in production of banana in the different parts of the world. Six genomic DNA components of BBTV isolate from Kandy, Sri Lanka (BBTV-K) were amplified by polymerase chain reaction (PCR) with specific primers using total DNA extracted from banana tissues showing typical symptoms of bunchy top disease. The amplicons were of expected size of 1.0-1.1 kb, which were cloned and sequenced. Analysis of sequence data revealed the presence of six DNA components; DNA-R, DNA-U3, DNA-S, DNA-N, DNA-M and DNA-C for Sri Lanka isolate. Comparisons of sequence data of DNA components followed by the phylogenetic analysis, grouped Sri Lanka-(Kandy) isolate in the Pacific Indian Oceans (PIO) group. Sri Lanka-(Kandy) isolate of BBTV is classified a new member of PIO group based on analysis of six components of the virus. PMID:27366766

  5. The Release of Trapped Gases from Amorphous Solid Water Films: I. “Top-Down” Crystallization-Induced Crack Propagation Probed using the Molecular Volcano

    SciTech Connect

    May, Robert A.; Smith, R. Scott; Kay, Bruce D.

    2013-03-14

    In this (Paper I) and the companion paper (Paper II) we investigate the mechanisms for the release of trapped gases from underneath of amorphous solid water (ASW) films. In prior work, we reported the episodic release of trapped gases in concert with the crystallization ASW, a phenomenon that we termed the "molecular volcano". The observed abrupt desorption is due to the formation of cracks that span the film to form a connected pathway for release. In this paper we utilize the "molecular volcano" desorption peak to characterize the formation of crystallization-induced cracks. We find that the crack length and distribution are independent of the trapped gas (Ar, Kr, Xe, CH4, N2, O2 or CO). Selective placement of the inert gas layer is used to show that cracks form near the top of the film and propagate downward into the film. Isothermal experiments reveal that, after some induction time, cracks propagate linearly in time with an Arrhenius dependent velocity corresponding to an activation energy of 54 kJ/mol. This value is consistent with the crystallization growth rate reported by others and establishes a direct connection between crystallization growth rate and the crack propagation rate. A two-step model in which nucleation and crystallization occurs in an induction zone near the top of the film followed by the propagation of a crystallization/crack front into the film is in good agreement with the temperature programmed desorption results.

  6. Electron-beam lithography and molecular liftoff for directed attachment of DNA nanostructures on silicon: top-down meets bottom-up.

    PubMed

    Pillers, Michelle; Goss, Valerie; Lieberman, Marya

    2014-06-17

    CONSPECTUS: Our work on lithographic patterning of DNA nanostructures was inspired by a collaboration on molecular electronic devices known as quantum-dot cellular automata or QCA. QCA is a paradigm for computation in which information is transmitted and processed through the interaction of coupled electrical charges or magnetic dipoles. We began to explore the idea of molecular scale QCA and found that ab initio methods, a thermodynamic Ising model, and larger scale circuit design work suggested that circuits that did computationally interesting things could function at room temperature if made from molecular QCA cells of chemically reasonable design. But how could the QCA cells be patterned to form the complex arrays needed for computationally interesting circuitry, and how could those arrays of molecular circuitry be integrated with conventional electronic inputs and outputs? Top-down methods lacked the spatial resolution and high level of parallelism needed to make molecular circuits. Bottom-up chemical synthesis lacked the ability to fabricate arbitrary and heterogeneous structures tens to hundreds of nanometers in size. Chemical self-assembly at the time could produce structures in the right size scale, but was limited to homogeneous arrays. A potential solution to this conundrum was just being demonstrated in the late 1990s and early 2000s: DNA nanostructures self-assembled from oligonucleotides, whose high information density could handle the creation of arbitrary structures and chemical inhomogeneity. Our group became interested in whether DNA nanostructures could function as self-assembling circuit boards for electrical or magnetic QCA systems. This Account focuses on what we learned about the interactions of DNA nanostructures with silicon substrates and, particularly, on how electron-beam lithography could be used to direct the binding of DNA nanostructures on a variety of functional substrates. PMID:24716716

  7. Estimate of Top-of-Atmosphere Albedo for a Molecular Atmosphere over Ocean using Clouds and the Earth's Radiant Energy System (CERES) Measurements

    NASA Technical Reports Server (NTRS)

    Kato, S.; Loeb, N. G.; Rutledge, C. K.

    2002-01-01

    The shortwave broadband albedo at the top of a molecular atmosphere over ocean between 40deg N and 40deg S is estimated using radiance measurements from the Clouds and the Earth's Radiant Energy System (CERES) instrument and the Visible Infrared Scanner (VIRS) aboard the Tropical Rainfall Measuring Mission (TRMM) satellite. The albedo monotonically increases from 0.059 at a solar zenith angle of 10deg to 0.107 at a solar zenith angle of 60deg. The estimated uncertainty in the albedo is 3.5 x 10(exp -3) caused by the uncertainty in CERES-derived irradiances, uncertainty in VIRS-derived aerosol optical thicknesses, variations in ozone and water vapor, and variations in surface wind speed. The estimated uncertainty is similar in magnitude to the standard deviation of 0.003 that is derived from 72 areas divided by 20deg latitude by 20deg longitude grid boxes. The empirically estimated albedo is compared with the modeled albedo using a radiative transfer model combined with an ocean surface bidirectional reflectivity model. The modeled albedo with standard tropical atmosphere is 0.061 and 0.111 at the solar zenith angles of 10deg and 60deg, respectively. This empirically estimated albedo can be used to estimate the direct radiative effect of aerosols at the top of the atmosphere over oceans.

  8. Top studies

    SciTech Connect

    T. Dorigo

    2003-01-02

    The top quark, discovered in 1994 at the Tevatron, has proven a very interesting particle. Its characteristics allow both to perform stringent tests of electroweak theory, and to search for new physics through a deviation from standard model predictions for several of its peculiar properties. I will review the status of top physics and briefly describe the potential of experiments of the near future.

  9. Top leads for swine influenza A/H1N1 virus revealed by steered molecular dynamics approach.

    PubMed

    Mai, Binh Khanh; Viet, Man Hoang; Li, Mai Suan

    2010-12-27

    Since March 2009, the rapid spread of infection during the recent A/H1N1 swine flu pandemic has raised concerns of a far more dangerous outcome should this virus become resistant to current drug therapies. Currently oseltamivir (tamiflu) is intensively used for the treatment of influenza and is reported effective for 2009 A/H1N1 virus. However, as this virus is evolving fast, some drug-resistant strains are emerging. Therefore, it is critical to seek alternative treatments and identify roots of the drug resistance. In this paper, we use the steered molecular dynamics (SMD) approach to estimate the binding affinity of ligands to the glycoprotein neuraminidase. Our idea is based on the hypothesis that the larger is the force needed to unbind a ligand from a receptor the higher its binding affinity. Using all-atom models with Gromos force field 43a1 and explicit water, we have studied the binding ability of 32 ligands to glycoprotein neuraminidase from swine flu virus A/H1N1. The electrostatic interaction is shown to play a more important role in binding affinity than the van der Waals one. We have found that four ligands 141562, 5069, 46080, and 117079 from the NSC set are the most promising candidates to cope with this virus, while peramivir, oseltamivir, and zanamivir are ranked 8, 11, and 20. The observation that these four ligands are better than existing commercial drugs has been also confirmed by our results on the binding free energies obtained by the molecular mechanics-Poisson-Boltzmann surface area (MM-PBSA) method. Our prediction may be useful for the therapeutic application. PMID:21090736

  10. Generalized Vibrational Perturbation Theory for Rotovibrational Energies of Linear, Symmetric and Asymmetric Tops: Theory, Approximations, and Automated Approaches to Deal with Medium-to-Large Molecular Systems

    PubMed Central

    Piccardo, Matteo; Bloino, Julien; Barone, Vincenzo

    2015-01-01

    Models going beyond the rigid-rotor and the harmonic oscillator levels are mandatory for providing accurate theoretical predictions for several spectroscopic properties. Different strategies have been devised for this purpose. Among them, the treatment by perturbation theory of the molecular Hamiltonian after its expansion in power series of products of vibrational and rotational operators, also referred to as vibrational perturbation theory (VPT), is particularly appealing for its computational efficiency to treat medium-to-large systems. Moreover, generalized (GVPT) strategies combining the use of perturbative and variational formalisms can be adopted to further improve the accuracy of the results, with the first approach used for weakly coupled terms, and the second one to handle tightly coupled ones. In this context, the GVPT formulation for asymmetric, symmetric, and linear tops is revisited and fully generalized to both minima and first-order saddle points of the molecular potential energy surface. The computational strategies and approximations that can be adopted in dealing with GVPT computations are pointed out, with a particular attention devoted to the treatment of symmetry and degeneracies. A number of tests and applications are discussed, to show the possibilities of the developments, as regards both the variety of treatable systems and eligible methods. © 2015 Wiley Periodicals, Inc. PMID:26345131

  11. Towards the fabrication of the top-contact electrode in molecular junctions by photoreduction of a metal precursor.

    PubMed

    Martín, Santiago; Pera, Gorka; Ballesteros, Luz M; Hope, Adam J; Marqués-González, Santiago; Low, Paul J; Pérez-Murano, Francesc; Nichols, Richard J; Cea, Pilar

    2014-03-17

    Langmuir films of 4-{[4-({4-[(trimethylsilyl)ethynyl]phenyl}ethynyl)phenyl]ethynyl} benzenaminium chloride ([1 H]Cl) undergo anion metathesis when assembled on an aqueous auric acid (HAuCl4 ) subphase. Subsequent transfer to solid supports gives well-formed Langmuir-Blodgett (LB) monolayers of [1 H]AuCl4 in which the trimethylsilyl group serves as the surface contacting group. Photoreduction of the aurate on these monolayers leads to the formation of metallic gold nanoislands, which were distributed over the surface of the film. Electrical properties of these nascent devices were determined by recording current-voltage (I-V) curves with conductive atomic force microscopy (c-AFM) using the PeakForce tunneling AFM (PF-TUNA) mode. This gives consistent sigmoidal I-V curves that are indicative of well-behaved junctions free of metallic filaments and short circuits. The photoreduction of a metal precursor incorporated onto monomolecular films is therefore proposed as an effective method for the fabrication of molecular junctions. PMID:24532391

  12. Investigation of InGaP/(In)AlGaAs/GaAs triple-junction top cells for smart stacked multijunction solar cells grown using molecular beam epitaxy

    NASA Astrophysics Data System (ADS)

    Sugaya, Takeyoshi; Mochizuki, Toru; Makita, Kikuo; Oshima, Ryuji; Matsubara, Koji; Okano, Yoshinobu; Niki, Shigeru

    2015-08-01

    We report high-quality InGaP/(In)AlGaAs/GaAs triple-junction solar cells fabricated using solid-source molecular beam epitaxy (MBE) for the first time. The triple-junction cells can be used as top cells for smart stacked multijunction solar cells. A growth temperature of 480 °C was found to be suitable for an (In)AlGaAs second cell to obtain high-quality tunnel junctions. The properties of AlGaAs solar cells were better than those of InAlGaAs solar cells when a second cell was grown at 480 °C. The high-quality InGaP/AlGaAs/GaAs solar cell had an impressive open-circuit voltage of 3.1 V. This result indicates that high-performance InGaP/AlGaAs/GaAs triple-junction solar cells can be fabricated using solid-source MBE.

  13. Architectural Tops

    ERIC Educational Resources Information Center

    Mahoney, Ellen

    2010-01-01

    The development of the skyscraper is an American story that combines architectural history, economic power, and technological achievement. Each city in the United States can be identified by the profile of its buildings. The design of the tops of skyscrapers was the inspiration for the students in the author's high-school ceramic class to develop…

  14. The twisted top

    NASA Astrophysics Data System (ADS)

    Thiffeault, Jean-Luc; Morrison, P. J.

    2001-05-01

    We describe a new type of top, the twisted top, obtained by appending a cocycle to the Lie-Poisson bracket for the charged heavy top, thus breaking its semidirect product structure. The twisted top has an integrable case that corresponds to the Lagrange (symmetric) top. We give a canonical description of the twisted top in terms of Euler angles. We also show by a numerical calculation of the largest Lyapunov exponent that the Kovalevskaya case of the twisted top is chaotic.

  15. Top physics at CDF

    SciTech Connect

    Julia Thom

    2004-06-24

    Precision studies of top quark properties are a primary goal of the Run II physics program at the Fermilab Tevatron. Marking the first stages of this program, the CDF collaboration presents recent results on top pair production cross section, single top physics and top mass, using between 109 and 200 pb{sup -1} of Run II data.

  16. Generation and Molecular Mapping of a Sequence Characterized Amplified Region Marker Linked with the Bct Gene for Resistance to Beet curly top virus in Common Bean.

    PubMed

    Larsen, Richard C; Miklas, Phillip N

    2004-04-01

    ABSTRACT A random amplified polymorphic DNA (RAPD) marker directly linked (0.0 cM) with a resistance gene was identified in a snap bean recombinant inbred population (Moncayo x Primo) consisting of 94 F(5:7) recombinant inbred lines that had uniform segregation for disease reaction to Beet curly top virus (BCTV) across three field locations. Resistance was conditioned by a single dominant allele tentatively designated Bct. Seven hundred and fifty decamer primers were screened to obtain the linked RAPD marker that was then converted to a sequence characterized amplified region (SCAR) marker SAS8.1550. The SCAR mapped within a cluster of resistance genes on linkage group B7 of the core map. A survey of 103 BCTV-resistant and -susceptible snap and dry bean genotypes was conducted using SAS8.1550. Results showed that the SCAR would be highly useful for marker-assisted selection of Bct in snap and dry bean originating from the Andean gene pool. Marker-assisted selection for Bct will expedite the development of BCTV-resistant cultivars and minimize the need for cumbersome pathogen tests. PMID:18944106

  17. Top quark physics

    SciTech Connect

    Ahmadov, A.; Azuelos, G.; Bauer, U.; Belyaev, A.; Berger, E. L.; Sullivan, Z.; Tait, T. M. P.

    2000-03-24

    The top quark, when it was finally discovered at Fermilab in 1995 completed the three-generation structure of the Standard Model (SM) and opened up the new field of top quark physics. Viewed as just another SM quark, the top quark appears to be a rather uninteresting species. Produced predominantly, in hadron-hadron collisions, through strong interactions, it decays rapidly without forming hadrons, and almost exclusively through the single mode t {r_arrow} Wb. The relevant CKM coupling V{sub tb} is already determined by the (three-generation) unitarity of the CKM matrix. Rare decays and CP violation are unmeasurable small in the SM. Yet the top quark is distinguished by its large mass, about 35 times larger than the mass of the next heavy quark, and intriguingly close to the scale of electroweak (EW) symmetry breaking. This unique property raises a number of interesting questions. Is the top quark mass generated by the Higgs mechanism as the SM predicts and is its mass related to the top-Higgs-Yukawa coupling? Or does it play an even more fundamental role in the EW symmetry breaking mechanism? If there are new particles lighter than the top quark, does the top quark decay into them? Could non-SM physics first manifest itself in non-standard couplings of the top quark which show up as anomalies in top quark production and decays? Top quark physics tries to answer these questions. Several properties of the top quark have already been examined at the Tevatron. These include studies of the kinematical properties of top production, the measurements of the top mass, of the top production cross-section, the reconstruction of t{bar t}pairs in the fully hadronic final states, the study of {tau} decays of the top quark, the reconstruction of hadronic decays of the W boson from top decays, the search for flavor changing neutral current decays, the measurement of the W helicity in top decays, and bounds on t{bar t} spin correlations. Most of these measurements are limited by

  18. Spherical Tippe Tops

    NASA Astrophysics Data System (ADS)

    Cross, Rod

    2013-03-01

    A tippe top (see Fig. 1) is usually constructed as a truncated sphere with a cylindrical peg on top, as indicated in Fig. 2(a). When spun rapidly on a horizontal surface, a tippe top spins about a vertical axis while rotating slowly about a horizontal axis until the peg touches the surface. At that point, weight is transferred to the peg, the truncated sphere rises off the surface, and the top spins on the peg until it is upright. A feature of a tippe top is that its center of mass, labeled G in Fig. 2, is below the geometric center of the sphere, C, when the top is at rest. That is where it will return if the top is tilted sideways and released since that is the stable equilibrium position. The fact that a tippe top turns upside down when it spins is therefore astonishing. The behavior of a tippe top is quite unlike that of a regular top since the spin axis remains closely vertical the whole time. The center of mass of a regular top can also rise, but the spin axis tilts upward as the top rises and enters a "sleeping" position.

  19. Spherical Tippe Tops

    ERIC Educational Resources Information Center

    Cross, Rod

    2013-01-01

    A tippe top (see Fig. 1) is usually constructed as a truncated sphere with a cylindrical peg on top, as indicated in Fig. 2(a). When spun rapidly on a horizontal surface, a tippe top spins about a vertical axis while rotating slowly about a horizontal axis until the peg touches the surface. At that point, weight is transferred to the peg, the…

  20. Dare We Teach Tops?

    ERIC Educational Resources Information Center

    Featonby, David

    2010-01-01

    "Tops" are mentioned in classical literature and references are even found in the ancient world. For many children a top is one of the first mechanical toys that they play with by themselves, yet a full appreciation of their motion is rare. My hope is that this article will stimulate the reader's interest in tops, will help with the first stages…

  1. Study of orotidine 5'-monophosphate decarboxylase in complex with the top three OMP, BMP, and PMP ligands by molecular dynamics simulation.

    PubMed

    Jamshidi, Shirin; Jalili, Seifollah; Rafii-Tabar, Hashem

    2015-01-01

    Catalytic mechanism of orotidine 5'-monophosphate decarboxylase (OMPDC), one of the nature most proficient enzymes which provides large rate enhancement, has not been fully understood yet. A series of 30 ns molecular dynamics (MD) simulations were run on X-ray structure of the OMPDC from Saccharomyces cerevisiae in its free form as well as in complex with different ligands, namely 1-(5'-phospho-D-ribofuranosyl) barbituric acid (BMP), orotidine 5'-monophosphate (OMP), and 6-phosphonouridine 5'-monophosphate (PMP). The importance of this biological system is justified both by its high rate enhancement and its potential use as a target in chemotherapy. This work focuses on comparing two physicochemical states of the enzyme (protonated and deprotonated Asp91) and three ligands (substrate OMP, inhibitor, and transition state analog BMP and substrate analog PMP). Detailed analysis of the active site geometry and its interactions is properly put in context by extensive comparison with relevant experimental works. Our overall results show that in terms of hydrogen bond occupancy, electrostatic interactions, dihedral angles, active site configuration, and movement of loops, notable differences among different complexes are observed. Comparison of the results obtained from these simulations provides some detailed structural data for the complexes, the enzyme, and the ligands, as well as useful insights into the inhibition mechanism of the OMPDC enzyme. Furthermore, these simulations are applied to clarify the ambiguous mechanism of the OMPDC enzyme, and imply that the substrate destabilization and transition state stabilization contribute to the mechanism of action of the most proficient enzyme, OMPDC. PMID:24559040

  2. F429 Regulation of Tunnels in Cytochrome P450 2B4: A Top Down Study of Multiple Molecular Dynamics Simulations.

    PubMed

    Mancini, Giordano; Zazza, Costantino

    2015-01-01

    The root causes of the outcomes of the single-site mutation in enzymes remain by and large not well understood. This is the case of the F429H mutant of the cytochrome P450 (CYP) 2B4 enzyme where the substitution, on the proximal surface of the active site, of a conserved phenylalanine 429 residue with histidine seems to hamper the formation of the active species, Compound I (porphyrin cation radical-Fe(IV) = O, Cpd I) from the ferric hydroperoxo (Fe(III)OOH-, Cpd 0) precursor. Here we report a study based on extensive molecular dynamic (MD) simulations of 4 CYP-2B4 point mutations compared to the WT enzyme, having the goal of better clarifying the importance of the proximal Phe429 residue on CYP 2B4 catalytic properties. To consolidate the huge amount of data coming from five simulations and extract the most distinct structural features of the five species studied we made an extensive use of cluster analysis. The results show that all studied single polymorphisms of F429, with different side chain properties: i) drastically alter the reservoir of conformations accessible by the protein, perturbing global dynamics ii) expose the thiolate group of residue Cys436 to the solvent, altering the electronic properties of Cpd0 and iii) affect the various ingress and egress channels connecting the distal sites with the bulk environment, altering the reversibility of these channels. In particular, it was observed that the wild type enzyme exhibits unique structural features as compared to all mutant species in terms of weak interactions (hydrogen bonds) that generate a completely different dynamical behavior of the complete system. Albeit not conclusive, the current computational investigation sheds some light on the subtle and critical effects that proximal single-site mutations can exert on the functional mechanisms of human microsomal CYPs which should go rather far beyond local structure characterization. PMID:26415031

  3. F429 Regulation of Tunnels in Cytochrome P450 2B4: A Top Down Study of Multiple Molecular Dynamics Simulations

    PubMed Central

    Mancini, Giordano; Zazza, Costantino

    2015-01-01

    The root causes of the outcomes of the single-site mutation in enzymes remain by and large not well understood. This is the case of the F429H mutant of the cytochrome P450 (CYP) 2B4 enzyme where the substitution, on the proximal surface of the active site, of a conserved phenylalanine 429 residue with histidine seems to hamper the formation of the active species, Compound I (porphyrin cation radical-Fe(IV) = O, Cpd I) from the ferric hydroperoxo (Fe(III)OOH-, Cpd 0) precursor. Here we report a study based on extensive molecular dynamic (MD) simulations of 4 CYP-2B4 point mutations compared to the WT enzyme, having the goal of better clarifying the importance of the proximal Phe429 residue on CYP 2B4 catalytic properties. To consolidate the huge amount of data coming from five simulations and extract the most distinct structural features of the five species studied we made an extensive use of cluster analysis. The results show that all studied single polymorphisms of F429, with different side chain properties: i) drastically alter the reservoir of conformations accessible by the protein, perturbing global dynamics ii) expose the thiolate group of residue Cys436 to the solvent, altering the electronic properties of Cpd0 and iii) affect the various ingress and egress channels connecting the distal sites with the bulk environment, altering the reversibility of these channels. In particular, it was observed that the wild type enzyme exhibits unique structural features as compared to all mutant species in terms of weak interactions (hydrogen bonds) that generate a completely different dynamical behavior of the complete system. Albeit not conclusive, the current computational investigation sheds some light on the subtle and critical effects that proximal single-site mutations can exert on the functional mechanisms of human microsomal CYPs which should go rather far beyond local structure characterization. PMID:26415031

  4. CDF Top Physics

    DOE R&D Accomplishments Database

    Tartarelli, G. F.; CDF Collaboration

    1996-05-01

    The authors present the latest results about top physics obtained by the CDF experiment at the Fermilab Tevatron collider. The data sample used for these analysis (about 110 pb{sup{minus}1}) represents almost the entire statistics collected by CDF during four years (1992--95) of data taking. This large data size has allowed detailed studies of top production and decay properties. The results discussed here include the determination of the top quark mass, the measurement of the production cross section, the study of the kinematics of the top events and a look at top decays.

  5. Top quark physics

    SciTech Connect

    Erbacher, Robin D.; /UC, Davis

    2005-10-01

    While the top quark was discovered in 1995 at the Fermilab Tevatron, a decade later they still have very little information about the top. As the heaviest particle yet discovered, the top quark is interesting in and of itself, but some speculate that it may play a special role in physics beyond the Standard Model. With Run 2 of the Tevatron well underway, they have the opportunity to study top quark properties with much better sensitivity, and to test whether top quarks behave as predicted by current theories. This article focuses on the basics of top quark physics at the Tevatron, highlighting only a sample of the many recent measurements, as new results are being released monthly, and constantly changing the landscape of our knowledge of top.

  6. Top Quark Mass Measurements

    SciTech Connect

    Heinson, A.P.; /UC, Riverside

    2006-08-01

    First observed in 1995, the top quark is one of a pair of third-generation quarks in the Standard Model of particle physics. It has charge +2/3e and a mass of 171.4 GeV, about 40 times heavier than its partner, the bottom quark. The CDF and D0 collaborations have identified several hundred events containing the decays of top-antitop pairs in the large dataset collected at the Tevatron proton-antiproton collider over the last four years. They have used these events to measure the top quark's mass to nearly 1% precision and to study other top quark properties. The mass of the top quark is a fundamental parameter of the Standard Model, and knowledge of its value with small uncertainty allows us to predict properties of the as-yet-unobserved Higgs boson. This paper presents the status of the measurements of the top quark mass.

  7. The Top Triangle Moose

    NASA Astrophysics Data System (ADS)

    Chivukula, R. S.; Christensen, N. D.; Coleppa, B.; Simmons, E. H.

    2011-01-01

    We introduce a deconstructed model that incorporates both Higgsless and top-color mechanisms. The model alleviates the typical tension in Higgsless models between obtaining the correct top quark mass and keeping Δρ small. It does so by singling out the top quark mass generation as arising from a Yukawa coupling to an effective top-Higgs which develops a small vacuum expectation value, while electroweak symmetry breaking results largely from a Higgsless mechanism. As a result, the heavy partners of the SM fermions can be light enough to be seen at the LHC.

  8. Top Physics at CDF

    SciTech Connect

    Moon, Chang-Seong

    2011-06-01

    We present the recent results of top-quark physics using up to 6 fb{sup -1} of p{bar p} collisions at a center of mass energy of {radical}s = 1.96 TeV analyzed by the CDF collaboration. Thanks to this large data sample, precision top quark measurements are now a reality at the Tevatron. Further, several new physics signals could appear in this large dataset. We will present the latest measurements of top quark intrinsic properties as well as direct searches for new physics in the top sector.

  9. Training Top 125

    ERIC Educational Resources Information Center

    Training, 2011

    2011-01-01

    Top companies realize how vital training is to their success and continue to invest in it, even in trying times. This article presents "Training" magazine's 11th annual ranking of the top companies with employee-sponsored workforce training and development. First-time No. 1 winner Farmers Insurance puts such a premium on learning that its new…

  10. Training Top 125

    ERIC Educational Resources Information Center

    Training, 2012

    2012-01-01

    The best learning and development organizations support business initiatives tactically "and" help drive strategic change. Verizon did just that, earning it the No. 1 spot for the first time on the Training Top 125. Verizon and the other 2012 Top 125 winners continued to invest in training, collectively dedicating a mean of 4.52 percent of their…

  11. The Driven Spinning Top

    ERIC Educational Resources Information Center

    Grosu, Ioan; Featonby, David

    2016-01-01

    This driven top is quite a novelty and can, with some trials, be made using the principles outlined here. This new top has many applications in developing both understanding and skills and these are detailed in the article. Depending on reader's available time and motivation they may feel an urge to make one themselves, or simply invest a few…

  12. Training Top 50.

    ERIC Educational Resources Information Center

    Training, 2001

    2001-01-01

    Identifies the top 50 companies in terms of the amount spent on training and development, the number of hours of training per employee, and percentage of payroll spent on training. Profiles the top five plus four additional companies selected by the magazine's editors. (SK)

  13. Top physics at CDF

    SciTech Connect

    Hughes, R.E.

    1997-01-01

    We report on top physics results using a 100 pb{sup -1} data sample of p{bar p} collisions at {radical}s = 1.8 TeV collected with the Collider Detector at Fermilab (CDF). We have identified top signals in a variety of decay channels, and used these channels to extract a measurement of the top mass and production cross section. A subset of the data (67 pb{sup -1}) is used to determine M{sub top} = 176 {+-} 8(stat) {+-} 10(syst) and {sigma}(tt) = 7.6 {sub -2.0}{sup +2.4} pb. We present studies of the kinematics of t{bar t} events and extract the first direct measurement of V{sub tb}. Finally, we indicate prospects for future study of top physics at the Tevatron.

  14. Top Quark Properties

    SciTech Connect

    Peters, Yvonne

    2011-12-01

    Since its discovery in 1995 by the CDF and D0 collaborations at the Fermilab Tevatron collider, the top quark has undergone intensive studies. Besides the Tevatron experiments, with the start of the LHC in 2010 a top quark factory started its operation. It is now possible to measure top quark properties simultaneously at four different experiments, namely ATLAS and CMS at LHC and CDF and D0 at Tevatron. Having collected thousands of top quarks each, several top quark properties have been measured precisely, while others are being measured for the first time. In this article, recent measurements of top quark properties from ATLAS, CDF, CMS and D0 are presented, using up to 5.4 fb{sup -1} of integrated luminosity at the Tevatron and 1.1 fb{sup -1} at the LHC. In particular, measurements of the top quark mass, mass difference, foward backward charge asymmetry, t{bar t} spin correlations, the ratio of branching fractions, W helicity, anomalous couplings, color flow and the search for flavor changing neutral currents are discussed.

  15. Top Quark Mass Measurements

    SciTech Connect

    Heinson, A. P.

    2006-11-17

    First observed in 1995, the top quark is one of a pair of third-generation quarks in the Standard Model of particle physics. It has charge +2/3e and a mass of 171.4 GeV, about 40 times heavier than its partner, the bottom quark. The CDF and DO collaborations have identified several hundred events containing the decays of top-antitop pairs in the large dataset collected at the Tevatron proton-antiproton collider over the last four years. They have used these events to measure the top quark's mass to nearly 1% precision and to study other top quark properties. The mass of the top quark is a fundamental parameter of the Standard Model, and knowledge of its value with small uncertainty allows us to predict properties of the as-yet-unobserved Higgs boson. This paper presents the status of the measurements of the top quark mass. It is based on a talk I gave at the Conference on the Intersections of Particle and Nuclear Physics in Puerto Rico, May 2006, which also included discussion of measurements of other top quark properties.

  16. The driven spinning top

    NASA Astrophysics Data System (ADS)

    Grosu, Ioan; Featonby, David

    2016-05-01

    This driven top is quite a novelty and can, with some trials, be made using the principles outlined here. This new top has many applications in developing both understanding and skills and these are detailed in the article. Depending on reader’s available time and motivation they may feel an urge to make one themselves, or simply invest a few pounds in the one that has been designed, tested and manufactured to a high standard. Either way the unique design of the driven top can provide several hours of interesting experimentation. Our aim here is simply to inform and inspire readers to further investigation and experimentation.

  17. Top physics: CDF results

    SciTech Connect

    K. Bloom

    2004-06-23

    The top quark plays an important role in the grand scheme of particle physics, and is also interesting on its own merits. We present recent results from CDF on top-quark physics based on 100-200 pb{sup -1} of p{bar p} collision data. We have measured the t{bar t} cross section in different decay modes using several different techniques, and are beginning our studies of top-quark properties. New analyses for this conference include a measurement of {sigma}{sub t{bar t}} in the lepton-plus-jets channel using a neural net to distinguish signal and background events, and measurements of top-quark branching fractions.

  18. Dare we teach tops?

    NASA Astrophysics Data System (ADS)

    Featonby, David

    2010-07-01

    Tops are mentioned in classical literature and references are even found in the ancient world. For many children a top is one of the first mechanical toys that they play with by themselves, yet a full appreciation of their motion is rare. My hope is that this article will stimulate the reader's interest in tops, will help with the first stages of understanding, and will provide inspiration for looking into the subject further. As a result of this, teachers will be happy and have the confidence to discuss these wonderful toys with their pupils. The article discusses tops and spinning objects of various types, and relates them to some of the physical principles that they demonstrate.

  19. Flat Top & rocky terrain

    NASA Technical Reports Server (NTRS)

    1997-01-01

    Flat Top, the rectangular rock at lower right, is part of a stretch of rocky terrain in this image, taken by the deployed Imager for Mars Pathfinder (IMP) on Sol 3. Dust has accumulated on the top of Flat Top, but is not present on the sides due to the steep angles of the rock. This dust may have been placed by dust storms moving across the Martian surface. Flat Top has been studied using several different color filters on the IMP camera.

    Mars Pathfinder is the second in NASA's Discovery program of low-cost spacecraft with highly focused science goals. The Jet Propulsion Laboratory, Pasadena, CA, developed and manages the Mars Pathfinder mission for NASA's Office of Space Science, Washington, D.C.

  20. 4 Top Healthy Snacks

    MedlinePlus

    ... this page please turn Javascript on. Feature: Reducing Childhood Obesity 4 Top Healthy Snacks Past Issues / Spring - Summer ... looking at whether or not the risks for childhood obesity could actually start before birth. The subject needs ...

  1. Top quark mass measurements

    SciTech Connect

    Hill, Christopher S.; /UC, Santa Barbara

    2004-12-01

    The top quark, with its extraordinarily large mass (nearly that of a gold atom), plays a significant role in the phenomenology of EWSB in the Standard Model. In particular, the top quark mass when combined with the W mass constrains the mass of the as yet unobserved Higgs boson. Thus, a precise determination of the mass of the top quark is a principal goal of the CDF and D0 experiments. With the data collected thus far in Runs 1 and 2 of the Tevatron, CDF and D0 have measured the top quark mass in both the lepton+jets and dilepton decay channels using a variety of complementary experimental techniques. The author presents an overview of the most recent of the measurements.

  2. Kernel mucking in top

    SciTech Connect

    LeFebvre, W.

    1994-08-01

    For many years, the popular program top has aided system administrations in examination of process resource usage on their machines. Yet few are familiar with the techniques involved in obtaining this information. Most of what is displayed by top is available only in the dark recesses of kernel memory. Extracting this information requires familiarity not only with how bytes are read from the kernel, but also what data needs to be read. The wide variety of systems and variants of the Unix operating system in today`s marketplace makes writing such a program very challenging. This paper explores the tremendous diversity in kernel information across the many platforms and the solutions employed by top to achieve and maintain ease of portability in the presence of such divergent systems.

  3. Top-ophilia

    SciTech Connect

    Quigg, Chris; /Fermilab

    2008-01-01

    Almost from the moment in June 1977 when the discovery of the Upsilon resonance revealed the existence of what we now call the bottom quark, physicists began searching for its partner. Through the years, as we established the electric charge and weak isospin of the b-quark, and detected the virtual influence of its mate, it became clear that the top quark must exist. Exactly at what mass, we couldn't say, but we knew just how top events would look. We also knew that top events would be rare--if the Tevatron could make them at all--and that picking out the events would pose a real challenge for the experimenters and their detectors.

  4. Top quark physics: Future measurements

    SciTech Connect

    Frey, R.; Vejcik, S.; Berger, E.L.

    1997-04-04

    The authors discuss the study of the top quark at future experiments and machines. Top`s large mass makes it a unique probe of physics at the natural electroweak scale. They emphasize measurements of the top quark`s mass, width, and couplings, as well as searches for rare or nonstandard decays, and discuss the complementary roles played by hadron and lepton colliders.

  5. Choosing a Top Ten.

    ERIC Educational Resources Information Center

    IUCN Bulletin, 1984

    1984-01-01

    Presents an annotated list of 34 animals and 32 plants which are candidates for a list of the top 10 endangered species. Also presents the criteria used to formulate these lists. They include the conservation value (urgency prominance, biological value) and operational considerations (such as cost factors) for each species. (JN)

  6. Top 100 Degree Producers.

    ERIC Educational Resources Information Center

    Black Issues in Higher Education, 2001

    2001-01-01

    Provides data on bachelor's degrees awarded to minority students in 1999-2000. Tables include total minority degrees and degrees awarded to African Americans, American Indians, Asian Americans, and Hispanics by type of school (uses Carnegie classification). Another table presents top disciplines by race/ethnicity. (EV)

  7. Top Concerns for 1993.

    ERIC Educational Resources Information Center

    Johnson, Sandra L.; Meyerson, Joel W.

    1992-01-01

    An annual national survey of college and university trustees indicates five top social, political, and economic areas of concern for higher education: public opinion about higher education; demographic trends; implications of family income and savings rate; effects of recession and unemployment; and the direction of national education policy. (MSE)

  8. Top Hispanic Degree Producers

    ERIC Educational Resources Information Center

    Diverse: Issues in Higher Education, 2012

    2012-01-01

    This article presents a list of the top 100 producers of associate, bachelor's and graduate degrees awarded to minority students based on research conducted by Dr. Victor M.H. Borden, professor of educational leadership and policy students at the Indiana University Bloomington. For the year 2012, the listings focus on Hispanic students. Data for…

  9. Ten Top Tech Trends

    ERIC Educational Resources Information Center

    McLester, Susan

    2008-01-01

    In this article, the author discusses the major technical issues, products, and practices of the day. The top ten tech trends are listed and discussed. These include: (1) data mining; (2) cyberbullying; (3) 21st century skills; (4) digital content; (5) learning at leisure; (6) personal responders; (7) mobile tools; (8) bandwidth; (9) open-source…

  10. Top Quark Production at CDF

    SciTech Connect

    Moed, Shulamit

    2010-02-10

    The large data samples of top quark candidate events collected at the Tevatron CDF II experiment allow for a variety of measurements to analyze the production of the top quark. This article discusses recent results of top quark production at CDF presented at the SUSY09 conference, including updates to the top pair production cross section, forward-backward asymmetry in tt-bar production, single top search, search for top resonances and a search for heavy top. The discussed measurements utilize up to 3.2 fb{sup -1} of integrated luminosity collected at CDF.

  11. Top quark production at CDF

    SciTech Connect

    Moed, Shulamit; /Harvard U.

    2010-01-01

    The large data samples of top quark candidate events collected at the Tevatron CDF II experiment allow for a variety of measurements to analyze the production of the top quark. This article discusses recent results of top quark production at CDF presented at the SUSY09 conference, including updates to the top pair production cross section, forward-backward asymmetry in t{bar t} production, single top search, search for top resonances and a search for heavy top. The discussed measurements utilize up to 3.2 fb{sup -1} of integrated luminosity collected at CDF.

  12. Dimerization and thiol sensitivity of the salicylic acid binding thimet oligopeptidases TOP1 and TOP2 define their functions in redox-sensitive cellular pathways

    PubMed Central

    Westlake, Timothy J.; Ricci, William A.; Popescu, George V.; Popescu, Sorina C.

    2015-01-01

    A long-term goal in plant research is to understand how plants integrate signals from multiple environmental stressors. The importance of salicylic acid (SA) in plant response to biotic and abiotic stress is known, yet the molecular details of the SA-mediated pathways are insufficiently understood. Our recent work identified the peptidases TOP1 and TOP2 as critical components in plant response to pathogens and programmed cell death (PCD). In this study, we investigated the characteristics of TOPs related to the regulation of their enzymatic activity and function in oxidative stress response. We determined that TOP1 and TOP2 interact with themselves and each other and their ability to associate in dimers is influenced by SA and the thiol-based reductant DTT. Biochemical characterization of TOP1 and TOP2 indicated distinct sensitivities to DTT and similarly robust activity under a range of pH values. Treatments of top mutants with Methyl Viologen (MV) revealed TOP1 and TOP2 as a modulators of the plant tolerance to MV, and that exogenous SA alleviates the toxicity of MV in top background. Finally, we generated a TOP-centered computational model of a plant cell whose simulation outputs replicate experimental findings and predict novel functions of TOP1 and TOP2. Altogether, our work indicates that TOP1 and TOP2 mediate plant responses to oxidative stress through spatially separated pathways and positions proteolysis in a network for plant response to diverse stressors. PMID:26042129

  13. Molecular geometric phase from the exact electron-nuclear factorization

    NASA Astrophysics Data System (ADS)

    Requist, Ryan; Tandetzky, Falk; Gross, E. K. U.

    2016-04-01

    The Born-Oppenheimer electronic wave function ΦRBO(r ) picks up a topological phase factor ±1 , a special case of Berry phase, when it is transported around a conical intersection of two adiabatic potential energy surfaces in R space. We show that this topological quantity reverts to a geometric quantity ei γ if the geometric phase γ =∮Im <ΦR|∇μΦR> .d Rμ is evaluated with the conditional electronic wave function ΦR(r ) from the exact electron-nuclear factorization ΦR(r ) χ (R ) instead of the adiabatic function ΦRBO(r ) . A model of a pseudorotating triatomic molecule, also applicable to dynamical Jahn-Teller ions in bulk crystals, provides examples of nontrivial induced vector potentials and molecular geometric phase from the exact factorization. The induced vector potential gives a contribution to the circulating nuclear current that cannot be removed by a gauge transformation. The exact potential energy surface is calculated and found to contain a term depending on the Fubini-Study metric for the conditional electronic wave function.

  14. Top of the hill.

    PubMed

    Lubell, Jennifer

    2009-08-24

    With healthcare reform the hottest topic in Washington (and at congressional town halls) this summer, it's no surprise President Barack Obama tops our 100 Most Powerful People in Healthcare ranking, joined by plenty of other power players on the Hill. "Clearly, the president is pushing hard on his goals to expand access to care, to reform health insurance and to control costs," says LifePoint's Bill Carpenter. PMID:19731430

  15. Wedge and Flat Top

    NASA Technical Reports Server (NTRS)

    1997-01-01

    Flat Top, the rectangular rock at right, is part of a stretch of rocky terrain in this image, taken by the deployed Imager for Mars Pathfinder (IMP) on Sol 3. Dust has accumulated on the top of Flat Top, but is not present on the sides due to the steep angles of the rock. This dust may have been placed by dust storms moving across the Martian surface. The rock dubbed 'Wedge' is at left. The objects have been studied using several different color filters on the IMP camera.

    Mars Pathfinder is the second in NASA's Discovery program of low-cost spacecraft with highly focused science goals. The Jet Propulsion Laboratory, Pasadena, CA, developed and manages the Mars Pathfinder mission for NASA's Office of Space Science, Washington, D.C. JPL is an operating division of the California Institute of Technology (Caltech). The Imager for Mars Pathfinder (IMP) was developed by the University of Arizona Lunar and Planetary Laboratory under contract to JPL. Peter Smith is the Principal Investigator.

  16. Cloud top entrainment instability and cloud top distributions

    NASA Technical Reports Server (NTRS)

    Boers, Reinout; Spinhirne, James D.

    1990-01-01

    Classical cloud-top entrainment instability condition formulation is discussed. A saturation point diagram is used to investigate the details of mixing in cases where the cloud-top entrainment instability criterion is satisfied.

  17. An optimized TOPS+ comparison method for enhanced TOPS models

    PubMed Central

    2010-01-01

    Background Although methods based on highly abstract descriptions of protein structures, such as VAST and TOPS, can perform very fast protein structure comparison, the results can lack a high degree of biological significance. Previously we have discussed the basic mechanisms of our novel method for structure comparison based on our TOPS+ model (Topological descriptions of Protein Structures Enhanced with Ligand Information). In this paper we show how these results can be significantly improved using parameter optimization, and we call the resulting optimised TOPS+ method as advanced TOPS+ comparison method i.e. advTOPS+. Results We have developed a TOPS+ string model as an improvement to the TOPS [1-3] graph model by considering loops as secondary structure elements (SSEs) in addition to helices and strands, representing ligands as first class objects, and describing interactions between SSEs, and SSEs and ligands, by incoming and outgoing arcs, annotating SSEs with the interaction direction and type. Benchmarking results of an all-against-all pairwise comparison using a large dataset of 2,620 non-redundant structures from the PDB40 dataset [4] demonstrate the biological significance, in terms of SCOP classification at the superfamily level, of our TOPS+ comparison method. Conclusions Our advanced TOPS+ comparison shows better performance on the PDB40 dataset [4] compared to our basic TOPS+ method, giving 90% accuracy for SCOP alpha+beta; a 6% increase in accuracy compared to the TOPS and basic TOPS+ methods. It also outperforms the TOPS, basic TOPS+ and SSAP comparison methods on the Chew-Kedem dataset [5], achieving 98% accuracy. Software Availability The TOPS+ comparison server is available at http://balabio.dcs.gla.ac.uk/mallika/WebTOPS/. PMID:20236520

  18. Top physics results at CDF

    SciTech Connect

    Vickey, Trevor; /Illinois U., Urbana

    2005-05-01

    The most recent results on top quark physics at CDF are reported. Measurements of cross-section and mass are presented, and the status of single top quark production searches are discussed. The results obtained from probing various top quark properties are also presented.

  19. Top quark physics: Future Measurements

    SciTech Connect

    Frey, Raymond; Gerdes, David; Jaros, John; Vejcik, Steve; Berger, Edmond L.; Chivukula, R. Sekhar; Cuypers, Frank; Drell, Persis S.; Fero, Michael; Hadley, Nicholas; Han, Tao; Heinson, Ann P.; Knuteson, Bruce; Larios, Francisco; Miettinen, Hannu; Orr, Lynne H.; Peskin, Michael E.; Rizzo, Thomas; Sarid, Uri; Schmidt, Carl; Stelzer, Tim; Sullivan, Zack

    1996-12-31

    We discuss the study of the top quark at future experiments and machines. Top's large mass makes it a unique probe of physics at the natural electroweak scale. We emphasize measurements of the top quark's mass, width, and couplings, as well as searches for rare or nonstandard decays, and discuss the complementary roles played by hadron and lepton colliders.

  20. Top quark mass measurements

    SciTech Connect

    L. Cerrito

    2004-07-16

    Preliminary results on the measurement of the top quark mass at the Tevatron Collider are presented. In the dilepton decay channel, the CDF Collaboration measures m{sub t} = 175.0{sub -16.9}{sup +17.4}(stat.){+-}8.4(syst.) GeV/c{sup 2}, using a sample of {approx} 126 pb{sup -1} of proton-antiproton collision data at {radical}s = 1.96 TeV (Run II). In the lepton plus jets channel, the CDF Collaboration measures 177.5{sub -9.4}{sup +12.7}(stat.) {+-} 7.1(syst.) GeV/c{sup 2}, using a sample of {approx} 102 pb{sup -1} at {radical}s = 1.96 TeV. The D0 Collaboration has newly applied a likelihood technique to improve the analysis of {approx} 125 pb{sup -1} of proton-antiproton collisions at {radical}s = 1.8 TeV (Run I), with the result: m{sub t} = 180.1 {+-} 3.6(stat.) {+-}3.9(syst.) GeV/c{sup 2}. The latter is combined with all the measurements based on the data collected in Run I to yield the most recent and comprehensive experimental determination of the top quark mass: m{sub t} = 178.0 {+-} 2.7(stat.) {+-} 3.3(syst.) GeV/c{sup 2}.

  1. Top quark physics at CDF

    SciTech Connect

    Potamianos, Karolos

    2011-12-01

    We present the recent results of top-quark physics using up to 6 fb{sup -1} of p{bar p} collisions analyzed by the CDF collaboration. The large number of top quark events analyzed, of the order of several thousands, allows stringent checks of the standard model predictions. Also, the top quark is widely believed to be a window to new physics. We present the latest measurements of top quark intrinsic properties as well as direct searches for new physics in the top sector.

  2. Tops and Writhing DNA

    NASA Astrophysics Data System (ADS)

    Samuel, Joseph; Sinha, Supurna

    2011-04-01

    The torsional elasticity of semiflexible polymers like DNA is of biological significance. A mathematical treatment of this problem was begun by Fuller using the relation between link, twist and writhe, but progress has been hindered by the non-local nature of the writhe. This stands in the way of an analytic statistical mechanical treatment, which takes into account thermal fluctuations, in computing the partition function. In this paper we use the well known analogy with the dynamics of tops to show that when subjected to stretch and twist, the polymer configurations which dominate the partition function admit a local writhe formulation in the spirit of Fuller and thus provide an underlying justification for the use of Fuller's "local writhe expression" which leads to considerable mathematical simplification in solving theoretical models of DNA and elucidating their predictions. Our result facilitates comparison of the theoretical models with single molecule micromanipulation experiments and computer simulations.

  3. Top quark physics

    SciTech Connect

    Menzione, A.

    1995-10-01

    Most of the material presented in this report, comes from contributions to the parallel session PL20 of this conference. We summarise the experimental results of direct production of Top quarks, coming from the CDF and C0 Collaborations at Fermilab, and compare these results to what one expects within current theoretical understanding. Particular attention is given to new results such as all hadronic modes of t{bar t} decay. As far as the mass is concerned, a comparison is made with precision measurements of related quantities, coming from LEP and other experiments. An attempt is made to look at the medium-term future and understand which variables and with what accuracy one can measure them with increased integrated luminosity.

  4. Top-Higgs and top-pion phenomenology in the top triangle moose model

    NASA Astrophysics Data System (ADS)

    Chivukula, R. Sekhar; Simmons, Elizabeth H.; Coleppa, Baradhwaj; Logan, Heather E.; Martin, Adam

    2011-03-01

    We discuss the deconstructed version of a topcolor-assisted technicolor model wherein the mechanism of top quark mass generation is separated from the rest of electroweak symmetry breaking. The minimal deconstructed version of this scenario is a “triangle moose” model, where the top quark gets its mass from coupling to a top-Higgs field, while the gauge boson masses are generated from a Higgsless sector. The spectrum of the model includes scalar (top-Higgs) and pseudoscalar (top-pion) states. In this paper, we study the properties of these particles, discuss their production mechanisms and decay modes, and suggest how best to search for them at the LHC.

  5. Top-Higgs and top-pion phenomenology in the top triangle moose model

    SciTech Connect

    Chivukula, R. Sekhar; Simmons, Elizabeth H.; Coleppa, Baradhwaj; Logan, Heather E.; Martin, Adam

    2011-03-01

    We discuss the deconstructed version of a topcolor-assisted technicolor model wherein the mechanism of top quark mass generation is separated from the rest of electroweak symmetry breaking. The minimal deconstructed version of this scenario is a ''triangle moose'' model, where the top quark gets its mass from coupling to a top-Higgs field, while the gauge boson masses are generated from a Higgsless sector. The spectrum of the model includes scalar (top-Higgs) and pseudoscalar (top-pion) states. In this paper, we study the properties of these particles, discuss their production mechanisms and decay modes, and suggest how best to search for them at the LHC.

  6. Top quark properties and single top at CMS

    NASA Astrophysics Data System (ADS)

    Skovpenon, K.; CMS Collaboration

    2016-07-01

    Measurements of top-quark properties as well as single top-quark production are presented, obtained from the CMS data collected in 2011 and 2012 at centre-of-mass energies of 7 and 8TeV. The results include measurements of the top pair charge asymmetry, the W helicity in top decays, the t bar{{t}} spin correlation and the search for anomalous couplings. The cross sections for the electroweak production of single top quarks in the t-channel and in association with W-bosons are measured and the results are used to place constraints on the CKM matrix element Vtb. In the t-channel the ratio of top and antitop production cross sections is determined and compared with predictions from different parton density distribution functions. The results are compared with predictions from the standard model as well as new physics models.

  7. Gas turbine topping combustor

    DOEpatents

    Beer, Janos; Dowdy, Thomas E.; Bachovchin, Dennis M.

    1997-01-01

    A combustor for burning a mixture of fuel and air in a rich combustion zone, in which the fuel bound nitrogen in converted to molecular nitrogen. The fuel rich combustion is followed by lean combustion. The products of combustion from the lean combustion are rapidly quenched so as to convert the fuel bound nitrogen to molecular nitrogen without forming NOx. The combustor has an air radial swirler that directs the air radially inward while swirling it in the circumferential direction and a radial fuel swirler that directs the fuel radially outward while swirling it in the same circumferential direction, thereby promoting vigorous mixing of the fuel and air. The air inlet has a variable flow area that is responsive to variations in the heating value of the fuel, which may be a coal-derived fuel gas. A diverging passage in the combustor in front of a bluff body causes the fuel/air mixture to recirculate with the rich combustion zone.

  8. Top physics results from CDF

    SciTech Connect

    Gomez, Gervasio; /Cantabria Inst. of Phys.

    2005-05-01

    The top quark is by far the most massive fundamental particle observed so far, and the study of its properties is interesting for several reasons ranging from its possible special role in electroweak symmetry breaking to its sensitivity to physics beyond the Standard Model. They present recent top physics results from CDF based on 160-320 pb{sup -1} of p{bar p} collision data at {radical}s = 1.96 TeV. The t{bar t} cross section and the top mass have been measured in different decay channels and using different methods. they have searched for evidence of single top production, setting upper limits on its production rate. Other results shown in this conference include studies of the polarization of W bosons from top decays, a search for charged Higgs decaying from top, and a search for additional heavy t' quarks.

  9. Top of Olympus Mons

    NASA Technical Reports Server (NTRS)

    2003-01-01

    MGS MOC Release No. MOC2-455, 17 August 2003

    Olympus Mons is considered to be the largest and tallest volcano in the Solar System. This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) picture shows the western summit region of Olympus Mons. This area is at an elevation just over 20 km (12 mi) above the 0 km martian datum. The bright feature on the right (east) side of the image is the uppermost wall of the caldera (collapse pit) at the top of the volcano. This image shows a lava flow that was cut by the pit walls when the caldera collapse occurred. Below (south of) the lava flow is a narrow channel formed by lava at some time in the distant past. This view of the summit region of Olympus Mons is located near 10.6oN, 134.0oW. The area shown is about 7.9 km (4.9 mi) across. Sunlight illuminates the scene from the right.

  10. Dark matter on top

    SciTech Connect

    Gómez, M.A.; Jackson, C.B.; Shaughnessy, G. E-mail: chris@uta.edu

    2014-12-01

    We consider a simplified model of fermionic dark matter which couples exclusively to the right-handed top quark via a renormalizable interaction with a color-charged scalar. We first compute the relic abundance of this type of dark matter and investigate constraints placed on the model parameter space by the latest direct detection data. We also perform a detailed analysis for the production of dark matter at the LHC for this model. We find several kinematic variables that allow for a clean signal extraction and we show that the parameter space of this model will be well probed during LHC Run-II. Finally, we investigate the possibility of detecting this type of dark matter via its annihilations into gamma rays. We compute the continuum and the line emission (which includes a possible ''Higgs in Space!'' line) and its possible discovery by future gamma-ray telescopes. We find that the annihilation spectrum has distinctive features which may distinguish it from other models.

  11. Top of the Top 100: First Professional Degrees.

    ERIC Educational Resources Information Center

    Black Issues in Higher Education, 1999

    1999-01-01

    Salutes the professional schools that have most consistently appeared at the top of the journal's annual ranking of Top 100 graduate and professional schools for granting the most degrees to African Americans. Included are five institutions granting the most first professional degrees in medicine and the 10 law schools. (CH)

  12. Gas turbine topping combustor

    DOEpatents

    Beer, J.; Dowdy, T.E.; Bachovchin, D.M.

    1997-06-10

    A combustor is described for burning a mixture of fuel and air in a rich combustion zone, in which the fuel bound nitrogen in converted to molecular nitrogen. The fuel rich combustion is followed by lean combustion. The products of combustion from the lean combustion are rapidly quenched so as to convert the fuel bound nitrogen to molecular nitrogen without forming NOx. The combustor has an air radial swirler that directs the air radially inward while swirling it in the circumferential direction and a radial fuel swirler that directs the fuel radially outward while swirling it in the same circumferential direction, thereby promoting vigorous mixing of the fuel and air. The air inlet has a variable flow area that is responsive to variations in the heating value of the fuel, which may be a coal-derived fuel gas. A diverging passage in the combustor in front of a bluff body causes the fuel/air mixture to recirculate with the rich combustion zone. 14 figs.

  13. Systematic studies of molecular vibrational anharmonicity and vibration-rotation interaction by self-consistent-field higher derivative methods: Applications to asymmetric and symmetric top and linear polyatomic molecules

    SciTech Connect

    Clabo, D.A. Jr.

    1987-04-01

    Inclusion of the anharmonicity normal mode vibrations (i.e., the third and fourth (and higher) derivatives of a molecular Born-Oppenheimer potential energy surface) is necessary in order to theoretically reproduce experimental fundamental vibrational frequencies of a molecule. Although ab initio determinations of harmonic vibrational frequencies may give errors of only a few percent by the inclusion of electron correlation within a large basis set for small molecules, in general, molecular fundamental vibrational frequencies are more often available from high resolution vibration-rotation spectra. Recently developed analytic third derivatives methods for self-consistent-field (SCF) wavefunctions have made it possible to examine with previously unavailable accuracy and computational efficiency the anharmonic force fields of small molecules.

  14. Learning at the Top. Symposium.

    ERIC Educational Resources Information Center

    2002

    This document contains three papers from a symposium on learning at the top that was conducted as part of a conference on human resource development (HRD). "Learning at the Top: An Investigation of Nonprofit CEOs' (Chief Executive Officers') Learning Experiences" (John J. Sherlock) reports on a study that used Mezirow's theory of adult learning as…

  15. Uncovering the single top: Observation of electroweak top quark production

    NASA Astrophysics Data System (ADS)

    Benitez, Jorge Armando

    The top quark is generally produced in quark and anti-quark pairs. However, the Standard Model also predicts the production of only one top quark which is mediated by the electroweak interaction, known as "Single Top." Single Top quark production is important because it provides a unique and direct way to measure the CKM matrix element Vtb, and can be used to explore physics possibilities beyond the Standard Model predictions. This dissertation presents the results of the observation of Single Top using 2.3 fb-1 of Data collected with the DO detector at the Fermilab Tevatron collider. The analysis includes the Single Top muon+jets and electron+jets final states and employs Boosted Decision Tress as a method to separate the signal from the background. The resulting Single Top cross section measurement is: spp→tb+X,tqb+X =3.74+0.95-0.74pb, 1 where the errors include both statistical and systematic uncertainties. The probability to measure a cross section at this value or higher in the absence of signal is p = 1.9 x 10-6. This corresponds to a standard deviation Gaussian equivalence of 4.6. When combining this result with two other analysis methods, the resulting cross section measurement is: spp→tb+X,tqb+X =3.94+/-0.88pb, 2 and the corresponding measurement significance is 5.0 standard deviations.

  16. A transient α-helical molecular recognition element in the disordered N-terminus of the Sgs1 helicase is critical for chromosome stability and binding of Top3/Rmi1

    PubMed Central

    Kennedy, Jessica A.; Daughdrill, Gary W.; Schmidt, Kristina H.

    2013-01-01

    The RecQ-like DNA helicase family is essential for the maintenance of genome stability in all organisms. Sgs1, a member of this family in Saccharomyces cerevisiae, regulates early and late steps of double-strand break repair by homologous recombination. Using nuclear magnetic resonance spectroscopy, we show that the N-terminal 125 residues of Sgs1 are disordered and contain a transient α-helix that extends from residue 25 to 38. Based on the residue-specific knowledge of transient secondary structure, we designed proline mutations to disrupt this α-helix and observed hypersensitivity to DNA damaging agents and increased frequency of genome rearrangements. In vitro binding assays show that the defects of the proline mutants are the result of impaired binding of Top3 and Rmi1 to Sgs1. Extending mutagenesis N-terminally revealed a second functionally critical region that spans residues 9–17. Depending on the position of the proline substitution in the helix functional impairment of Sgs1 function varied, gradually increasing from the C- to the N-terminus. The multiscale approach we used to interrogate structure/function relationships in the long disordered N-terminal segment of Sgs1 allowed us to precisely define a functionally critical region and should be generally applicable to other disordered proteins. PMID:24038467

  17. A transient α-helical molecular recognition element in the disordered N-terminus of the Sgs1 helicase is critical for chromosome stability and binding of Top3/Rmi1.

    PubMed

    Kennedy, Jessica A; Daughdrill, Gary W; Schmidt, Kristina H

    2013-12-01

    The RecQ-like DNA helicase family is essential for the maintenance of genome stability in all organisms. Sgs1, a member of this family in Saccharomyces cerevisiae, regulates early and late steps of double-strand break repair by homologous recombination. Using nuclear magnetic resonance spectroscopy, we show that the N-terminal 125 residues of Sgs1 are disordered and contain a transient α-helix that extends from residue 25 to 38. Based on the residue-specific knowledge of transient secondary structure, we designed proline mutations to disrupt this α-helix and observed hypersensitivity to DNA damaging agents and increased frequency of genome rearrangements. In vitro binding assays show that the defects of the proline mutants are the result of impaired binding of Top3 and Rmi1 to Sgs1. Extending mutagenesis N-terminally revealed a second functionally critical region that spans residues 9-17. Depending on the position of the proline substitution in the helix functional impairment of Sgs1 function varied, gradually increasing from the C- to the N-terminus. The multiscale approach we used to interrogate structure/function relationships in the long disordered N-terminal segment of Sgs1 allowed us to precisely define a functionally critical region and should be generally applicable to other disordered proteins. PMID:24038467

  18. Wave Engine Topping Cycle Assessment

    NASA Technical Reports Server (NTRS)

    Welch, Gerard E.

    1996-01-01

    The performance benefits derived by topping a gas turbine engine with a wave engine are assessed. The wave engine is a wave rotor that produces shaft power by exploiting gas dynamic energy exchange and flow turning. The wave engine is added to the baseline turboshaft engine while keeping high-pressure-turbine inlet conditions, compressor pressure ratio, engine mass flow rate, and cooling flow fractions fixed. Related work has focused on topping with pressure-exchangers (i.e., wave rotors that provide pressure gain with zero net shaft power output); however, more energy can be added to a wave-engine-topped cycle leading to greater engine specific-power-enhancement The energy addition occurs at a lower pressure in the wave-engine-topped cycle; thus the specific-fuel-consumption-enhancement effected by ideal wave engine topping is slightly lower than that effected by ideal pressure-exchanger topping. At a component level, however, flow turning affords the wave engine a degree-of-freedom relative to the pressure-exchanger that enables a more efficient match with the baseline engine. In some cases, therefore, the SFC-enhancement by wave engine topping is greater than that by pressure-exchanger topping. An ideal wave-rotor-characteristic is used to identify key wave engine design parameters and to contrast the wave engine and pressure-exchanger topping approaches. An aerodynamic design procedure is described in which wave engine design-point performance levels are computed using a one-dimensional wave rotor model. Wave engines using various wave cycles are considered including two-port cycles with on-rotor combustion (valved-combustors) and reverse-flow and through-flow four-port cycles with heat addition in conventional burners. A through-flow wave cycle design with symmetric blading is used to assess engine performance benefits. The wave-engine-topped turboshaft engine produces 16% more power than does a pressure-exchanger-topped engine under the specified topping

  19. Status of the top quark: Top production cross section and top properties

    SciTech Connect

    Boisvert, V.; /Rochester U.

    2006-08-01

    This report describes the latest cross section and property measurements associated with the top quark at the Tevatron Run II. The largest data sample used is 760 pb{sup -1} of integrated luminosity. Due to its large mass, the top quark might be involved in the process of electroweak symmetry breaking, making it a useful probe for signs of new physics.

  20. Top Mass Measurement at CDF

    SciTech Connect

    Kordas, Kostas; /Frascati

    2006-03-01

    We report on recent measurements of the top quark mass using t{bar t} candidate events selected in {approx_equal} 320 pb{sup -1} of data from the ''Run II'' operation period of the Tevatron p{bar p} collider. More emphasis is given on the best single measurement to date (M{sub top} = 173.5{sub -3.8}{sup +3.9} GeV/c{sup 2}), provided by CDF using the ''lepton plus jets'' channel, where one W decays to a lepton-neutrino pair and the other into quarks (top quarks decay to Wb almost 100% of the time).

  1. Progress in Top Quark Physics

    SciTech Connect

    Thomson, Evelyn J.

    2006-07-11

    Experimental measurements of the properties of the top quark have improved and will continue to improve significantly, with the excellent operation of the CDF and D0 experiments and the Tevatron pp-bar collider at the Fermi National Accelerator Laboratory. All of the final state experimental signatures from top quark production and decay are being analysed to test if this most massive quark is sensitive to new physics beyond the standard model. So far, observations are consistent with the standard model. New techniques have dramatically improved the precision of the top quark mass measurement to 1.7% and set the stage for a sub-1% measurement by 2008. This improved knowledge of the top quark mass sharpens the standard model prediction for the mass of the undiscovered Higgs boson, with implications for Higgs studies at the future LHC and ILC.

  2. Progress in top quark physics

    SciTech Connect

    Thomson, Evelyn J.; /Pennsylvania U.

    2006-02-01

    Experimental measurements of the properties of the top quark have improved and will continue to improve significantly, with the excellent operation of the CDF and D0 experiments and the Tevatron p{bar p} collider at the Fermi National Accelerator Laboratory. All of the final state experimental signatures from top quark production and decay are being analyzed to test if this most massive quark is sensitive to new physics beyond the standard model. So far, observations are consistent with the standard model. New techniques have dramatically improved the precision of the top quark mass measurement to 1.7% and set the stage for a sub-1% measurement by 2008. This improved knowledge of the top quark mass sharpens the standard model prediction for the mass of the undiscovered Higgs boson, with implications for Higgs studies at the future LHC and ILC.

  3. Forum outlines top emerging technologies

    NASA Astrophysics Data System (ADS)

    Extance, Andy

    2015-04-01

    Additive manufacturing, next-generation robotics, "sense and avoid" drones that fly themselves, artificial intelligence and "neuromorphic" computing have all made it into the World Economic Forum's top 10 emerging technologies for 2015.

  4. Australia's Next Top Fraction Model

    ERIC Educational Resources Information Center

    Gould, Peter

    2013-01-01

    Peter Gould suggests Australia's next top fraction model should be a linear model rather than an area model. He provides a convincing argument and gives examples of ways to introduce a linear model in primary classrooms.

  5. Trajectory correction propulsion for TOPS

    NASA Technical Reports Server (NTRS)

    Long, H. R.; Bjorklund, R. A.

    1972-01-01

    A blowdown-pressurized hydrazine propulsion system was selected to provide trajectory correction impulse for outer planet flyby spacecraft as the result of cost/mass/reliability tradeoff analyses. Present hydrazine component and system technology and component designs were evaluated for application to the Thermoelectric Outer Planet Spacecraft (TOPS); while general hydrazine technology was adequate, component design changes were deemed necessary for TOPS-type missions. A prototype hydrazine propulsion system was fabricated and fired nine times for a total of 1600 s to demonstrate the operation and performance of the TOPS propulsion configuration. A flight-weight trajectory correction propulsion subsystem (TCPS) was designed for the TOPS based on actual and estimated advanced components.

  6. Top 10 Products of 2011

    ERIC Educational Resources Information Center

    American School & University, 2011

    2011-01-01

    In 2011, American School & University (AS&U) showcased some of the hottest products in the industry. This article presents the top ten most requested products as determined by readers. The top one on the list is the Bulb crusher which can cut recycling costs by 50%, can hold 1,350 4-foot lamps in a single 55-gallon drum, can crush a 4-foot lamp in…

  7. Uncovering the single top: observation of electroweak top quark production

    SciTech Connect

    Benitez, Jorge Armando

    2009-01-01

    The top quark is generally produced in quark and anti-quark pairs. However, the Standard Model also predicts the production of only one top quark which is mediated by the electroweak interaction, known as 'Single Top'. Single Top quark production is important because it provides a unique and direct way to measure the CKM matrix element Vtb, and can be used to explore physics possibilities beyond the Standard Model predictions. This dissertation presents the results of the observation of Single Top using 2.3 fb-1 of Data collected with the D0 detector at the Fermilab Tevatron collider. The analysis includes the Single Top muon+jets and electron+jets final states and employs Boosted Decision Tress as a method to separate the signal from the background. The resulting Single Top cross section measurement is: (1) σ(p$\\bar{p}$→ tb + X, tqb + X) = 3.74-0.74+0.95 pb, where the errors include both statistical and systematic uncertainties. The probability to measure a cross section at this value or higher in the absence of signal is p = 1.9 x 10-6. This corresponds to a standard deviation Gaussian equivalence of 4.6. When combining this result with two other analysis methods, the resulting cross section measurement is: (2) σ(p$\\bar{p}$ → tb + X, tqb + X) = 3.94 ± 0.88 pb, and the corresponding measurement significance is 5.0 standard deviations.

  8. SW New Mexico Oil Well Formation Tops

    DOE Data Explorer

    Shari Kelley

    2015-10-21

    Rock formation top picks from oil wells from southwestern New Mexico from scout cards and other sources. There are differing formation tops interpretations for some wells, so for those wells duplicate formation top data are presented in this file.

  9. Consider topped crude for FCC

    SciTech Connect

    Louder, K.E.; Juno, E.J.; Kulapaditharom, L.

    1985-09-01

    A case study is presented that illustrates the mechanics for evaluating use of topped crude to load the FCC for more profit. Declining product demands combined with high crude costs has shut down many refineries and left others operting well below design capacity. The study illustrates the step-by-step requirements to debottleneck an existing Kellogg Orthoflow Model B FCC to process topped crude mixed with gas oils. This study was limited to the catalytic converter defined as the reactor, regenerator, air blower, and wet gas compressor. The scope was to examine the ability to process topped crude and to consider modernizing the FCC to employ riser cracking and complete CO combustion regeneration.

  10. Light 't Hooft top partners

    NASA Astrophysics Data System (ADS)

    Cacciapaglia, Giacomo; Parolini, Alberto

    2016-04-01

    Vectorlike quarks, usually dubbed top partners, are a common presence in composite Higgs models. Being composite objects, their mass is expected to be of the order of their inverse size, that is the condensation scale of the new strong interactions. Light top partners, while not being a generic prediction, are, however, often considered in phenomenological models. We suggest that their lightness may be due to the matching of global 't Hooft anomalies of the underlying theory. We check this mechanism in explicit models, showing that, in one case, composite fermions with the quantum numbers of the top quark obtain a mass which is controlled by a soft breaking term and can be made parametrically small.

  11. Top Quark Spin Correlations - Theory

    SciTech Connect

    Parke, Stephen J.; /Fermilab

    2012-02-01

    The top quark decay width (G{sub F}m{sub t}{sup 3} {approx} 1 GeV) is much larger than the QCD hadronization scale ({Lambda}{sub QCD} {approx} 0.1 GeV) and much larger than the spin decorrelation scale ({Lambda}{sub QCD}{sup 2}/m{sub t} {approx} 0.1 MeV). Therefore, spin correlations in top quark pair production are reflected in angular correlations of the decay products, see [1] and [2].

  12. Top Compositeness and Precision Unification

    NASA Astrophysics Data System (ADS)

    Agashe, Kaustubh; Contino, Roberto; Sundrum, Raman

    2005-10-01

    The evolution of standard model gauge couplings is studied in a nonsupersymmetric scenario in which the hierarchy problem is resolved by Higgs compositeness above the weak scale. It is argued that massiveness of the top quark combined with precision tests of the bottom quark imply that the right-handed top must also be composite. If, further, the standard model gauge symmetry is embedded into a simple subgroup of the unbroken composite-sector flavor symmetry, then precision coupling unification is shown to occur at ˜1015GeV, to a degree comparable to supersymmetric unification.

  13. TOPS attitude propulsion subsystem technology

    NASA Technical Reports Server (NTRS)

    Moynihan, P. I.

    1971-01-01

    The thermoelectric outer-planet spacecraft (TOPS) attitude propulsion subsystem effort is summarized. It includes the tradeoff rationale that went into the selection of anhydrous hydrazine as the propellant, and a brief description of three types of 0.445-N (100-mlbf) thrusters that were purchased for in-house evaluation. A discussion is also included of the 0.2224-N (50-mlbf)-developed thrusters and their integration with a portable, completely enclosed, propulsion module that was designed and developed to support the TOPS single-axis attitude control tests in the celestarium.

  14. Training Top 10 Hall of Fame

    ERIC Educational Resources Information Center

    Training, 2012

    2012-01-01

    Microsoft Corporation and SCC Soft Computer are the newest inductees into the Training Top 10 Hall of Fame, joining the ranks of the 11 companies named to the hall since its inception in 2008 (Wyeth Pharmaceuticals subsequently was acquired by Pfizer Inc. in 2009). These 11 companies held Top 10 spots in the Training Top 50, Top 100, and now Top…

  15. Kowalevski top in quantum mechanics

    SciTech Connect

    Matsuyama, A.

    2013-09-15

    The quantum mechanical Kowalevski top is studied by the direct diagonalization of the Hamiltonian. The spectra show different behaviors depending on the region divided by the bifurcation sets of the classical invariant tori. Some of these spectra are nearly degenerate due to the multiplicity of the invariant tori. The Kowalevski top has several symmetries and symmetry quantum numbers can be assigned to the eigenstates. We have also carried out the semiclassical quantization of the Kowalevski top by the EBK formulation. It is found that the semiclassical spectra are close to the exact values, thus the eigenstates can be also labeled by the integer quantum numbers. The symmetries of the system are shown to have close relations with the semiclassical quantum numbers and the near-degeneracy of the spectra. -- Highlights: •Quantum spectra of the Kowalevski top are calculated. •Semiclassical quantization is carried out by the EBK formulation. •Quantum states are labeled by the semiclassical integer quantum numbers. •Multiplicity of the classical torus makes the spectra nearly degenerate. •Symmetries, quantum numbers and near-degenerate spectra are closely related.

  16. Top 100--Graduate Degree Producers

    ERIC Educational Resources Information Center

    Borden, Victor M. H.

    2009-01-01

    The Top 100 degree tables published in this edition of Diverse, and the many more detailed tables included on the Diverse Web site, delineate the institutions that have conferred the most master's, doctoral and first professional degrees to students of color in academic year 2007-2008. Each table shows the number of degrees for a specific minority…

  17. The Top 100: Associate Rankings

    ERIC Educational Resources Information Center

    Blackmon, Olivia

    2009-01-01

    This year, Diverse has added a new addition to its annual Top 100 degree producers series--recognizing, with this edition, the institutions that award the most associate degrees to students of color. More than half of minority undergraduate students start their degree quest at a community college with 55 percent of all Hispanic and Native American…

  18. [Top five neonatal articles 2015].

    PubMed

    Flamant, C; Fischer Fumeaux, C J

    2016-09-01

    This review includes five randomized controlled trials, published in the Medline database in 2015, which were selected by the Scientific commission of the French society of neonatology, taking into account their influence in perinatology. This selection was presented during the specific "Top five" session in the French congress of neonatal research. PMID:27431853

  19. Race to Top Applications Scrutinized

    ERIC Educational Resources Information Center

    Sawchuk, Stephen; Maxwell, Lesli A.

    2010-01-01

    As peer reviewers for the U.S. Department of Education begin to comb through the thousands of pages of applications for $4 billion in federal Race to the Top Fund grants, they'll be under pressure to determine which are most worthy of funding: those that promise the most, or those with the best chance of delivering. In a competition whose criteria…

  20. Top quark mass and kinematics

    SciTech Connect

    Barberis, Emanuela; /Northeastern U.

    2006-05-01

    A summary of the results on the measurement of the Top Quark mass and the study of the kinematics of the t{bar t} system at the Tevatron collider is presented here. Results from both the CDF and D0 collaborations are reported.

  1. "Top School Problems" Are Myths.

    ERIC Educational Resources Information Center

    Males, Mike

    1992-01-01

    A well-known "study" comparing the top school problems of 1940 (talking and gum chewing) with those of 1987 (drug abuse, pregnancy, and violence) is nonexistent. In 1940, 49 percent of all youth did not finish high school, 37,000 teenagers died from violence or disease, and 335,000 teens gave birth. Educators should discount pastoral memories and…

  2. Observation of the Top Quark

    DOE R&D Accomplishments Database

    Kim, S. B.

    1995-08-01

    Top quark production is observed in{bar p}p collisions at{radical}s= 1.8 TeV at the Fermilab Tevatron. The Collider Detector at Fermilab (CDF) and D{O} observe signals consistent with t{bar t} to WWb{bar b}, but inconsistent with the background prediction by 4.8{sigma} (CDF), 4.6a (D{O}). Additional evidence for the top quark Is provided by a peak in the reconstructed mass distribution. The kinematic properties of the excess events are consistent with the top quark decay. They measure the top quark mass to be 176{plus_minus}8(stat.){plus_minus}10(sys.) GeV/c{sup 2} (CDF), 199{sub -21}{sup+19}(stat.){plus_minus}22(sys.) GeV/c{sup 2} (D{O}), and the t{bar t} production cross section to be 6.8{sub -2.4}{sup+3.6}pb (CDF), 6.4{plus_minus}2.2 pb (D{O}).

  3. The Top STEM Degree Producers

    ERIC Educational Resources Information Center

    Diverse: Issues in Higher Education, 2012

    2012-01-01

    This article presents a list of the top Science, Technology, Engineering, and Mathematics (STEM) degree producers in the U.S. This list is broken down into seven categories: (1) Total Minority Research/Scholarship and Other Doctoral: Mathematics and Statistics; (2) Total Minority Bachelors: Biological and Biomedical Sciences; (3) Total Minority…

  4. The Top Theological Degree Producers

    ERIC Educational Resources Information Center

    Diverse: Issues in Higher Education, 2012

    2012-01-01

    Each year, "Diverse: Issues in Higher Education" publishes a list of the Top 100 producers of associate, bachelor's and graduate degrees awarded to minority students based on research conducted by Dr. Victor M. H. Borden, professor of educational leadership and policy studies at Indiana University Bloomington. This year, for the first time, it has…

  5. Top physics at D0

    SciTech Connect

    Klima, B.; D0 Collaboration

    1995-09-01

    The D0 collaboration reports on the observation of the Standard Model top quark in p{anti p} collisions at {radical}s = 1.8 TeV at the Fermilab Tevatron. The authors have searched for t{anti t} production with an integrated luminosity of approximately 50 pb{sup {minus}1} in the dilepton and single-lepton decay channels, with and without tagging of b quark jets. They observe 17 events with an expected background of 3.8 {+-} 0.6 events. The probability for an upward fluctuation of the background to produce the observed signal is 2 {times} 10{sup {minus}6} (equivalent to 4.6 standard deviations). The kinematic properties of the excess events are consistent with top quark decay. They measure the top quark mass to be 199{sub {minus}21}{sup +19} (stat.) {sub {minus}21}{sup +14} (syst.) GeV/c{sup 2} and its production cross section to be 6.4 {+-} 2.2 pb. D0 also sees a hadronic W mass peak (W {yields} jj) in the t{bar t} data events. Preliminary results from multivariate analyses and from the t{bar t} data events. Preliminary results from multivariate analyses and from the t{bar t} {yields} all-jets channel are discussed. Preliminary determination of the top quark mass using dilepton events yields 145 {+-} 25 (stat.) {+-}20 (syst.) GeV/C{sup 2}.

  6. Kinematic top analyses at CDF

    SciTech Connect

    Cobal-Grassman, M.; CDF Collaboration

    1996-01-01

    We present an update of the top quark analysis using kinematic techniques in {rho}{ovr string {rho}} collisions at {radical}s = 1.8 TeV with the Collider Detector at Fermilab (CDF). We reported before on a study which used 19.3 pb{sup -1} of data from the 1992-93 collider run, but now we use a larger data sample of 67 pb{sup -1}. First, we analyze the total transverse energy of the hard collision in W+{ge}3 jet events, showing the likely presence of a t{ovr string t} component in the event sample. Next, we compare in more detail the kinematic structure of W+{ge}3 jet events with expectations for top pair production and with background processes, predominantly direct W+ jet production. We again find W+{ge}3 jet events which cannot be explained in terms of background, but show kinematic features as expected from top. These events also show evidence for beauty quarks. The findings confirm the observation of top events made earlier in the data of the 1992-93 collider run.

  7. The 2002 Training Top 100.

    ERIC Educational Resources Information Center

    Training, 2002

    2002-01-01

    Identifies the top 100 companies in terms of the amount spent on training and development, the number of hours of training per employee, percentage of payroll spent on training, and tuition allotment per employee. Describes best practices in succession planning and leadership development, mentoring, and job shadowing and provides a detailed…

  8. The 2003 Training Top 100.

    ERIC Educational Resources Information Center

    Galvin, Tammy

    2003-01-01

    Identifies the top 100 U.S. companies in terms of the amount spent on training and development, the number of hours of training per employee, percentage of payroll spent on training, and tuition allotment per employee. Describes best practices in succession planning and leadership development, mentoring, and job shadowing and provides a detailed…

  9. Top Jets at the LHC

    SciTech Connect

    Almeida, L.G.; Lee, S.J.; Perez, G.; Sung, I.; Virzi, J.

    2008-10-06

    We investigatethe reconstruction of high pT hadronically-decaying top quarksat the Large Hadron Collider. One of the main challenges in identifying energetictop quarks is that the decay products become increasingly collimated. This reducesthe efficacy of conventional reconstruction methods that exploit the topology of thetop quark decay chain. We focus on the cases where the decay products of the topquark are reconstructed as a single jet, a"top-jet." The most basic"top-tag" methodbased on jet mass measurement is considered in detail. To analyze the feasibility ofthe top-tagging method, both theoretical and experimental aspects of the large QCDjet background contribution are examined. Based on a factorization approach, wederive a simple analytic approximation for the shape of the QCD jet mass spectrum.We observe very good agreement with the Monte Carlo simulation. We consider high pT tt bar production in the Standard Model as an example, and show that our theoretical QCD jet mass distributions can efficiently characterize the background via sideband analyses. We show that with 25 fb-1 of data, our approach allows us to resolve top-jets with pT _> 1 TeV, from the QCD background, and about 1.5 TeV top-jets with 100 fb-1, without relying on b-tagging. To further improve the significancewe consider jet shapes (recently analyzed in 0807.0234 [hep-ph]), which resolve thesubstructure of energy flow inside cone jets. A method of measuring the top quarkpolarization by using the transverse momentum of the bottom quark is also presented.The main advantages of our approach are: (i) the mass distributions are driven byfirst principle calculations, instead of relying solely on Monte Carlo simulation; (ii) for high pT jets (pT _> 1 TeV), IR-safe jet shape variables are robust against detectorresolution effects. Our analysis can be applied to other boosted massive particlessuch as the electroweak gauge bosons and the Higgs.

  10. Top quark production at the Tevatron

    SciTech Connect

    Varnes, Erich W.; /Arizona U.

    2010-09-01

    The Fermilab Tevatron has, until recently, been the only accelerator with sufficient energy to produce top quarks. The CDF and D0 experiments have collected large samples of top quarks. We report on recent top quark production measurements of the single top and t{bar t} production cross sections, as well as studies of the t{bar t} invariant mass distribution and a search for highly boosted top quarks.

  11. Properties of the Top Quark

    SciTech Connect

    Wicke, Daniel; /Wuppertal U., Dept. Math.

    2009-08-01

    The aim of particle physics is the understanding of elementary particles and their interactions. The current theory of elementary particle physics, the Standard Model, contains twelve different types of fermions which (neglecting gravity) interact through the gauge bosons of three forces. In addition a scalar particle, the Higgs boson, is needed for theoretical consistency. These few building blocks explain all experimental results found in the context of particle physics, so far. Nevertheless, it is believed that the Standard Model is only an approximation to a more complete theory. First of all the fourth known force, gravity, has withstood all attempts to be included until now. Furthermore, the Standard Model describes several features of the elementary particles like the existence of three families of fermions or the quantisation of charges, but does not explain these properties from underlying principles. Finally, the lightness of the Higgs boson needed to explain the symmetry breaking is difficult to maintain in the presence of expected corrections from gravity at high scales. This is the so called hierarchy problem. In addition astrophysical results indicate that the universe consists only to a very small fraction of matter described by the Standard Model. Large fractions of dark energy and dark matter are needed to describe the observations. Both do not have any correspondence in the Standard Model. Also the very small asymmetry between matter and anti-matter that results in the observed universe built of matter (and not of anti-matter) cannot be explained until now. It is thus an important task of experimental particle physics to test the predictions of the Standard Model to the best possible accuracy and to search for deviations pointing to necessary extensions or modifications of our current theoretical understanding. The top quark was predicted to exist by the Standard Model as the partner of the bottom quark. It was first observed in 1995 by the

  12. Boosted top quarks and jet structure

    NASA Astrophysics Data System (ADS)

    Schätzel, Sebastian

    2015-09-01

    The Large Hadron Collider is the first particle accelerator that provides high enough energy to produce large numbers of boosted top quarks. The decay products of these top quarks are confined to a cone in the top quark flight direction and can be clustered into a single jet. Top quark reconstruction then amounts to analysing the structure of the jet and looking for subjets that are kinematically compatible with top quark decay. Many techniques have been developed in this context to identify top quarks in a large background of non-top jets. This article reviews the results obtained using data recorded in the years 2010-2012 by the experiments ATLAS and CMS. Studies of Standard Model top quark production and searches for new massive particles that decay to top quarks are presented.

  13. Thermoelectric Outer Planets Spacecraft (TOPS)

    NASA Technical Reports Server (NTRS)

    1973-01-01

    The research and advanced development work is reported on a ballistic-mode, outer planet spacecraft using radioisotope thermoelectric generator (RTG) power. The Thermoelectric Outer Planet Spacecraft (TOPS) project was established to provide the advanced systems technology that would allow the realistic estimates of performance, cost, reliability, and scheduling that are required for an actual flight mission. A system design of the complete RTG-powered outer planet spacecraft was made; major technical innovations of certain hardware elements were designed, developed, and tested; and reliability and quality assurance concepts were developed for long-life requirements. At the conclusion of its active phase, the TOPS Project reached its principal objectives: a development and experience base was established for project definition, and for estimating cost, performance, and reliability; an understanding of system and subsystem capabilities for successful outer planets missions was achieved. The system design answered long-life requirements with massive redundancy, controlled by on-board analysis of spacecraft performance data.

  14. Attitude propulsion technology for TOPS

    NASA Technical Reports Server (NTRS)

    Moynihan, P. I.

    1972-01-01

    The thermoelectric outer planet spacecraft (TOPS) attitude propulsion subsystem (APS) effort is discussed. It includes the tradeoff rationale that went into the selection of an anhydrous hydrazine baseline system, followed by a discussion of the 0.22 N thruster and its integration into a portable, self-contained propulsion module that was designed, developed, and man rated to support the TOPS single-axis attitude control tests. The results of a cold-start feasibility demonstration with a modified thruster are presented. A description of three types of 0.44 thrusters that were procured for in-house evaluation is included along with the results of the test program. This is followed by a description of the APS feed system components, their evaluations, and a discussion of an evaluation of elastomeric material for valve seat seals. A list of new technology items which will be of value for application to future systems of this type is included.

  15. Scalar top study: Detector optimization

    SciTech Connect

    Milstene, C.; Sopczak, A.; /Lancaster U.

    2006-09-01

    A vertex detector concept of the Linear Collider Flavor Identification (LCFI) collaboration, which studies pixel detectors for heavy quark flavor identification, has been implemented in simulations for c-quark tagging in scalar top studies. The production and decay of scalar top quarks (stops) is particularly interesting for the development of the vertex detector as only two c-quarks and missing energy (from undetected neutralinos) are produced for light stops. Previous studies investigated the vertex detector design in scenarios with large mass differences between stop and neutralino, corresponding to large visible energy in the detector. In this study we investigate the tagging performance dependence on the vertex detector design in a scenario with small visible energy for the International Linear Collider (ILC).

  16. Top decays in extended models

    SciTech Connect

    Gaitan, R.; Miranda, O. G.; Cabral-Rosetti, L. G.

    2009-04-20

    Top quark decays are interesting as a mean to test the Standard Model (SM) predictions. The Cabbibo-Kobayashi-Maskawa (CKM)-suppressed process t{yields}cWW, and the rare decays t{yields}cZ, t{yields}H{sup 0}+c, and t{yields}c{gamma} an excellent window to probe the predictions of theories beyond the SM. We evaluate the flavor changing neutral currents (FCNC) decay t{yields}H{sup 0}+c in the context of Alternative Left-Right symmetric Models (ALRM) with extra isosinglet heavy fermions; the FCNC decays may place at tree level and are only supressed by the mixing between ordinary top and charm quarks. We also comment on the decay process t{yields}c+{gamma}, which involves radiative corrections.

  17. Cloud Top Scanning radiometer (CTS)

    NASA Technical Reports Server (NTRS)

    1978-01-01

    A scanning radiometer to be used for measuring cloud radiances in each of three spectral regions is described. Significant features incorporated in the Cloud Top Scanner design are: (1) flexibility and growth potential through use of easily replaceable modular detectors and filters; (2) full aperture, multilevel inflight calibration; (3) inherent channel registration through employment of a single shared field stop; and (4) radiometric sensitivity margin in a compact optical design through use of Honeywell developed (Hg,Cd)Te detectors and preamplifiers.

  18. Observation of the top quark

    SciTech Connect

    Greenlee, H.; D0 Collaboration

    1995-05-01

    The DO collaboration reports on a search for the Standard Model top quark in p{bar p} collisions at {radical}s = 1.8 TeV at the Fermilab Tevatron, with an integrated luminosity of approximately 50 pb{sup {minus}1}. We have searched for t{bar t} production in the dilepton and single-lepton decay channels, with and without tagging of b quark jets. We observe 17 events with an expected background of 3.8 {plus_minus} 0.6 events. The probability for an upward fluctuation of the background to produce the observed signal is 2 {times} 10{sup {minus}6} (equivalent to 4.6 standard deviations). The kinematic properties of the excess events are consistent with top quark decay. We conclude that we have observed the top quark and measure its mass to be 199{sub {minus}21}{sup +19} (stat.) {plus_minus}22 (syst.) GeV/c{sup 2} and its production cross section to be 6.4 {plus_minus} 2.2 pb.

  19. The top 10 oomycete pathogens in molecular plant pathology

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Oomycetes form a deep lineage of eukaryotic organisms that includes a large number of plant pathogens that threaten natural and managed ecosystems. We undertook a survey to query the community for their ranking of plant pathogenic oomycete taxa based on scientific and economic importance. In total, ...

  20. Top quark studies at hadron colliders

    SciTech Connect

    Sinervo, P.K.; CDF Collaboration

    1996-08-01

    The techniques used to study top quarks at hadron colliders are presented. The analyses that discovered the top quark are described, with emphasis on the techniques used to tag {ital b} quark jets in candidate events. The most recent measurements of top quark properties by the CDF and D{null} collaborations are reviewed, including the top quark cross section, mass, branching fractions and production properties. Future top quark studies at hadron colliders are discussed, and predictions for event yields and uncertainties in the measurements of top quark properties are presented.

  1. Top quark studies at hadron colliders

    SciTech Connect

    Sinervo, P.K.

    1997-01-01

    The techniques used to study top quarks at hadron colliders are presented. The analyses that discovered the top quark are described, with emphasis on the techniques used to tag b quark jets in candidate events. The most recent measurements of top quark properties by the CDF and DO Collaborations are reviewed, including the top quark cross section, mass, branching fractions, and production properties. Future top quark studies at hadron colliders are discussed, and predictions for event yields and uncertainties in the measurements of top quark properties are presented.

  2. Heavy flavour physics from top to bottom

    SciTech Connect

    Paulini, M.; CDF and D0 Collaboration

    1998-02-01

    We review the status of heavy flavour physics at the Fermilab Tevatron collider by summarizing recent top quark and B physics results from CDF and D0. In particular we discuss the measurement of the top quark mass and top production cross section as well as B meson lifetimes and time dependent B{anti B} mixing results. An outlook of perspectives for top and B physics in Run II starting in 1999 is also given.

  3. Heavy flavour physics from top to bottom

    SciTech Connect

    Paulini, M.; CDF and D0 Collaborations

    1997-01-01

    We review the status of heavy flavour physics at the Fermilab Tevatron collider by summarizing recent top quark and B physics results from CDF and D0. In particular we discuss the measurement of the top quark mass and top production cross section as well as B meson lifetimes and time dependent B{bar B} mixing results. An outlook of perspectives for top and B physics in Run II starting in 1999 is also given. 38 refs., 23 figs., 8 tabs.

  4. Table-top job analysis

    SciTech Connect

    Not Available

    1994-12-01

    The purpose of this Handbook is to establish general training program guidelines for training personnel in developing training for operation, maintenance, and technical support personnel at Department of Energy (DOE) nuclear facilities. TTJA is not the only method of job analysis; however, when conducted properly TTJA can be cost effective, efficient, and self-validating, and represents an effective method of defining job requirements. The table-top job analysis is suggested in the DOE Training Accreditation Program manuals as an acceptable alternative to traditional methods of analyzing job requirements. DOE 5480-20A strongly endorses and recommends it as the preferred method for analyzing jobs for positions addressed by the Order.

  5. Top 10 TARN research publications.

    PubMed

    Edwards, Antoinette

    2015-12-01

    The last 25 years have seen Trauma Audit and Research Network's (TARN) research agenda develop into a significant portfolio of over 100 publications, including a number of international collaborations. Holding the largest trauma registry in Europe, TARN continues to provide researchers with the ability to pursue their interests in both epidemiological and clinical topics relating to traumatic injury. This edition of the Emergency Medicine Journal provides an opportunity to celebrate some of these papers with a 'Top 10', which have been voted by members of the TARN Research Committee on the basis of their impact. PMID:26598632

  6. HUBBLE'S TOP TEN GRAVITATIONAL LENSES

    NASA Technical Reports Server (NTRS)

    2002-01-01

    The NASA Hubble Space Telescope serendipitous survey of the sky has uncovered exotic patterns, rings, arcs and crosses that are all optical mirages produced by a gravitational lens, nature's equivalent of having giant magnifying glass in space. Shown are the top 10 lens candidates uncovered in the deepest 100 Hubble fields. Hubble's sensitivity and high resolution allow it to see faint and distant lenses that cannot be detected with ground-based telescopes whose images are blurred by Earth's atmosphere. [Top Left] - HST 01248+0351 is a lensed pair on either side of the edge-on disk lensing galaxy. [Top Center] - HST 01247+0352 is another pair of bluer lensed source images around the red spherical elliptical lensing galaxy. Two much fainter images can be seen near the detection limit which might make this a quadruple system. [Top Right] - HST 15433+5352 is a very good lens candidate with a bluer lensed source in the form of an extended arc about the redder elliptical lensing galaxy. [Middle Far Left] - HST 16302+8230 could be an 'Einstein ring' and the most intriguing lens candidate. It has been nicknamed the 'the London Underground' since it resembles that logo. [Middle Near Left] - HST 14176+5226 is the first, and brightest lens system discovered in 1995 with the Hubble telescope. This lens candidate has now been confirmed spectroscopically using large ground-based telescopes. The elliptical lensing galaxy is located 7 billion light-years away, and the lensed quasar is about 11 billion light-years distant. [Middle Near Right] - HST 12531-2914 is the second quadruple lens candidate discovered with Hubble. It is similar to the first, but appears smaller and fainter. [Middle Far Right] - HST 14164+5215 is a pair of bluish lensed images symmetrically placed around a brighter, redder galaxy. [Bottom Left] - HST 16309+8230 is an edge-on disk-like galaxy (blue arc) which has been significantly distorted by the redder lensing elliptical galaxy. [Bottom Center] - HST 12368

  7. Top 10 TARN research publications

    PubMed Central

    Edwards, Antoinette

    2015-01-01

    The last 25 years have seen Trauma Audit and Research Network's (TARN) research agenda develop into a significant portfolio of over 100 publications, including a number of international collaborations. Holding the largest trauma registry in Europe, TARN continues to provide researchers with the ability to pursue their interests in both epidemiological and clinical topics relating to traumatic injury. This edition of the Emergency Medicine Journal provides an opportunity to celebrate some of these papers with a ‘Top 10’, which have been voted by members of the TARN Research Committee on the basis of their impact. PMID:26598632

  8. MHD Integrated Topping Cycle Project

    SciTech Connect

    Not Available

    1992-07-01

    This eighteenth quarterly technical progress report of the MHD Integrated Topping cycle Project presents the accomplishments during the period November 1, 1991 to January 31, 1992. The precombustor is fully assembled. Manufacturing of all slagging stage components has been completed. All cooling panels were welded in place and the panel/shell gap was filled with RTV. Final combustor assembly is in progress. The low pressure cooling subsystem (LPCS) was delivered to the CDIF. Second stage brazing issues were resolved. The construction of the two anode power cabinets was completed.

  9. In Praise of Top-Down Leadership

    ERIC Educational Resources Information Center

    Dufour, Richard

    2007-01-01

    In the ongoing debate of the efficacy of top-down versus bottom-up strategies to improve school districts, top-down is clearly losing. Many district leaders are reluctant to champion improvement for fear of being labeled with the epithet "top-down leader," the unkindest cut of all. In this article, the author presents the change processes in three…

  10. MHD integrated topping cycle project

    NASA Astrophysics Data System (ADS)

    1992-01-01

    The overall objective of the project is to design and construct prototypical hardware for an integrated MHD topping cycle, and conduct long duration proof-of-concept tests of integrated system at the US DOE Component Development and Integration Facility in Butte, Montana. The results of the long duration tests will augment the existing engineering design data base on MHD power train reliability, availability, maintainability, and performance, and will serve as a basis for scaling up the topping cycle design to the next level of development, an early commercial scale power plant retrofit. The components of the MHD power train to be designed, fabricated, and tested include: A slagging coal combustor with a rated capacity of 50 MW thermal input, capable of operation with an Eastern (Illinois no. 6) or Western (Montana Rosebud) coal, a segmented supersonic nozzle, a supersonic MHD channel capable of generating at least 1.5 MW of electrical power, a segmented supersonic diffuser section to interface the channel with existing facility quench and exhaust systems, a complete set of current control circuits for local diagonal current control along the channel, and a set of current consolidation circuits to interface the channel with the existing facility inverter.

  11. MHD Integrated Topping Cycle Project

    SciTech Connect

    Not Available

    1992-03-01

    The Magnetohydrodynamics (MHD) Integrated Topping Cycle (ITC) Project represents the culmination of the proof-of-concept (POC) development stage in the US Department of Energy (DOE) program to advance MHD technology to early commercial development stage utility power applications. The project is a joint effort, combining the skills of three topping cycle component developers: TRW, Avco/TDS, and Westinghouse. TRW, the prime contractor and system integrator, is responsible for the 50 thermal megawatt (50 MW{sub t}) slagging coal combustion subsystem. Avco/TDS is responsible for the MHD channel subsystem (nozzle, channel, diffuser, and power conditioning circuits), and Westinghouse is responsible for the current consolidation subsystem. The ITC Project will advance the state-of-the-art in MHD power systems with the design, construction, and integrated testing of 50 MW{sub t} power train components which are prototypical of the equipment that will be used in an early commercial scale MHD utility retrofit. Long duration testing of the integrated power train at the Component Development and Integration Facility (CDIF) in Butte, Montana will be performed, so that by the early 1990's, an engineering data base on the reliability, availability, maintainability and performance of the system will be available to allow scaleup of the prototypical designs to the next development level. This Sixteenth Quarterly Technical Progress Report covers the period May 1, 1991 to July 31, 1991.

  12. Top quark physics at CDF

    SciTech Connect

    Caner, A.; CDF Collaboration

    1996-08-01

    We present preliminary results on top quark physics recently obtained by the CDF collaboration. The data sample consists of 110 {ital pb}{sup -1} of {ital p{anti p}} collisions at {radical}{ital s} = 1.8 TeV, collected with the Collider Detector at Fermilab during the period 1992 - 1995. We report on the {ital t{anti t}} production cross section and on the top quark mass. The measurements are made in three topologies, corresponding to the decay modes of the {ital Wb} pairs in the final state: lepton + multi-jets, dilepton and all hadronic final state. The analysis performed on the single lepton sample yields the most accurate measurements, due to the good acceptance and the favorable signal to noise ratio obtained after applying some b-tagging techniques. In this channel we measure: {sigma}{sub {ital t{anti t}}} = 6.8{sup +2.3}{sub -1.8} pb M{sub {ital t}} = 175.6 {+-} 5.7 ({ital stat}) {+-} 7.1 ({ital syst.}) {ital GeV/c{sup 2}} Combining the cross sections measured with the lepton + multi-jet and dilepton data we obtain: {sigma}{sub {ital t{anti t}}} = 7.5{sup +1.9}{sub -1.6} {ital pb} A preliminary investigation of the production mechanism of the {ital t{anti t}} system is shown and compared to Standard Model expectations.

  13. Top quark electromagnetic dipole moments

    NASA Astrophysics Data System (ADS)

    Bouzas, Antonio O.; Larios, F.

    2015-11-01

    The magnetic and electric dipole moments of the top quark are constrained indirectly by the Br(B → Xsγ) and the ACP(B → Xsγ) measurements. They can also be tested by top quark production and decay processes. The recent measurement of production by CDF are used to set direct constraints. The B → Xsγ measurements by themselves define an allowed parameter region that sets up stringent constraints on both dipole moments. The measurement by CDF has a ∼ 37% error that is too large to set any competitive bounds, for which a much lower 5% error would be required. For the LHC it is found that with its higher energy the same measurement could indeed further constrain the allowed parameter region given by the B → Xsγ measurement [1]. In addition, the proposed LHeC experiment (electron- proton) could provide even more stringent constraints than the LHC via the photoproduction channel [2].

  14. MHD Integrated Topping Cycle Project

    SciTech Connect

    Not Available

    1992-01-01

    The overall objective of the project is to design and construct prototypical hardware for an integrated MHD topping cycle, and conduct long duration proof-of-concept tests of integrated system at the US DOE Component Development and Integration Facility in Butte, Montana. The results of the long duration tests will augment the existing engineering design data base on MHD power train reliability, availability, maintainability, and performance, and will serve as a basis for scaling up the topping cycle design to the next level of development, an early commercial scale power plant retrofit. The components of the MHD power train to be designed, fabricated, and tested include: A slagging coal combustor with a rated capacity of 50 MW thermal input, capable of operation with an Eastern (Illinois {number sign}6) or Western (Montana Rosebud) coal, a segmented supersonic nozzle, a supersonic MHD channel capable of generating at least 1.5 MW of electrical power, a segmented supersonic diffuser section to interface the channel with existing facility quench and exhaust systems, a complete set of current control circuits for local diagonal current control along the channel, and a set of current consolidation circuits to interface the channel with the existing facility inverter.

  15. CP Violation in Single Top Quark Production

    SciTech Connect

    Geng, Weigang

    2012-01-01

    We present a search for CP violation in single top quark production with the DØ experiment at the Tevatron proton-antiproton collider. CP violation in the top electroweak interaction results in different single top quark production cross sections for top and antitop quarks. We perform the search in the single top quark final state using 5.4 fb-1 of data, in the s-channel, t-channel, and for both combined. At this time, we do not see an observable CP asymmetry.

  16. Top quark physics at the LHC

    NASA Astrophysics Data System (ADS)

    Kim, Tae Jeong

    2014-04-01

    In 2011, an integrated luminosity of more than 5 fb-1 at 7 TeV has been delivered by the LHC. The measurement of the cross section in top quark pair production and in single top quark production, top quark mass, top quark properties and new physics searches in top quark decays have been performed at the CMS experiment with various integrated luminosities. An overview of the latest results of these measurements and searches by the time of ICFP 2012 conference will be presented.

  17. Top Quark Studies at D0

    SciTech Connect

    Peters, Reinhild Yvonne

    2014-11-26

    Years after its discovery in 1995 by CDF and D0, the top quark still undergoes intense investigations at the Tevatron. Using up to the full Run II data sample, new measurements of top quark production and properties by the D0 Collaboration are presented. In particular, the first observation of single top quark s-channel production, the measurement of differential tbar t distributions, forward-backward tbar t asymmetry, a new measurement of the top quark mass, and a measurement of the top quark charge are discussed.

  18. Measurements of top quark properties at CDF

    SciTech Connect

    Kraan, Aafke C.; /Pennsylvania U.

    2006-11-01

    The top quark with its mass of about 172 GeV/c{sup 2} is the most massive fundamental particle observed by experiment. In this talk they highlight the most recent measurements of several top quark properties performed with the CDF detector based on data samples corresponding to integrated luminosities up to 1 fb{sup -1}. These results include a search for top quark pair production via new massive resonances, measurements of the helicity of the W boson from top-quark decay, and a direct limit on the lifetime of the top quark.

  19. LHC limits on the top-Higgs in models with strong top-quark dynamics

    SciTech Connect

    Chivukula, R. Sekhar; Simmons, Elizabeth H.; Coleppa, Baradhwaj; Logan, Heather E.; Martin, Adam

    2011-11-01

    LHC searches for the standard model Higgs boson in WW or ZZ decay modes place strong constraints on the top-Higgs state predicted in many models with new dynamics preferentially affecting top quarks. Such a state couples strongly to top quarks, and is therefore produced through gluon fusion at a rate enhanced relative to the rate for the standard model Higgs boson. A top-Higgs state with mass less than 300 GeV is excluded at 95% C.L. if the associated top-pion has a mass of 150 GeV, and the constraint is even stronger if the mass of the top-pion state exceeds the top-quark mass or if the top-pion decay constant is a substantial fraction of the weak scale. These results have significant implications for theories with strong top dynamics, such as topcolor-assisted technicolor, top-seesaw models, and certain Higgsless models.

  20. Radiatively Driven Turbulence at the Cloud Top

    NASA Astrophysics Data System (ADS)

    de Lozar, Alberto; Mellado, Juan Pedro

    2012-11-01

    We use Direct Numerical Simulations to investigate a radiatively-driven smoke cloud-top mixing layer. This configuration mimics relevant aspects of stratocumuls clouds, in particular the mixing across an inversion that bounds a radiatively driven turbulent flow. A 1D formulation is employed for the radiation calculations. Below the inversion a convective boundary layer propagates downwards into the cloud-bulk. The convective boundary layer decouples from the inversion properties other than the injected buoyancy flux. This buoyancy flux is equal to the total radiative cooling minus the cooling of the inversion layer where the cloud mixes with the free atmosphere. An exact equation at a properly defined inversion point divides the inversion cooling into three components: a molecular flux, a turbulent flux and the direct radiative cooling by the smoke inside the inversion layer. The normalized turbulent flux levels to a constant value (0 . 175 +/- 0 . 05), which is independent of the stratification. As suggested by earlies studies, we observe that the turbulent entrainment only occurs at the small scales and that eddies larger than four optical lengths (50 m in a typical DYCOMS-II cloud) perform little or no entrainment.

  1. Top-Down and Free

    NASA Astrophysics Data System (ADS)

    Schillaci, Michael

    2007-11-01

    The ``Top-Down Physics'' (TDP) project is aimed at unifying material traditionally covered in Classical Mechanics, and Electricity & Magnetism, as well as elements of Quantum Mechanics and Statistical Dynamics at the undergraduate level. The main computational platforms for the student projects have been LaTeX, MAPLE and JAVA. Relevant theoretic, algorithmic and technical (software) elements are introduced as needed to simulate laboratory-style experiments carried out in class. Ideally, solutions developed by ``senior'' students can be ``beta- tested'' during classroom and laboratory demonstrations to lower- level students. In this way, the curriculum naturally ``folds'' onto itself. Current efforts include the use of the Open Source Physics and Maxima to develop a platform-independent (and free) framework for the TDP framework.

  2. MHD Integrated Topping Cycle Project

    SciTech Connect

    Not Available

    1992-07-01

    This seventeenth quarterly technical progress report of the MHD Integrated Topping Cycle Project presents the accomplishments during the period August 1, 1991 to October 31, 1991. Manufacturing of the prototypical combustor pressure shell has been completed including leak, proof, and assembly fit checking. Manufacturing of forty-five cooling panels was also completed including leak, proof, and flow testing. All precombustor internal components (combustion can baffle and swirl box) were received and checked, and integration of the components was initiated. A decision was made regarding the primary and backup designs for the 1A4 channel. The assembly of the channel related prototypical hardware continued. The cathode wall electrical wiring is now complete. The mechanical design of the diffuser has been completed.

  3. Top quark mass measurements at CDF

    SciTech Connect

    Brubaker, Erik; /Chicago U., EFI

    2006-05-01

    The mass of the top quark M{sub top} is interesting both as a fundamental parameter of the standard model and as an important input to precision electroweak tests. The Collider Detector at Fermilab (CDF) has a robust program of top quark mass analyses, including the most precise single measurement, M{sub top} = 173.4 {+-} 2.8 GeV/c{sup 2}, using 680 pb{sup -1} of p{bar p} collision data. A combination of current results from CDF gives M{sub top} = 172.0 {+-} 2.7 GeV/c{sup 2}, surpassing the stated goal of 3 GeV/c{sup 2} precision using 2 fb{sup -1} of data. Finally, a combination with current D0 results gives a world average top quark mass of 172.5 {+-} 2.3 GeV/c{sup 2}.

  4. TOP500 Supercomputers for June 2004

    SciTech Connect

    Strohmaier, Erich; Meuer, Hans W.; Dongarra, Jack; Simon, Horst D.

    2004-06-23

    23rd Edition of TOP500 List of World's Fastest Supercomputers Released: Japan's Earth Simulator Enters Third Year in Top Position MANNHEIM, Germany; KNOXVILLE, Tenn.;&BERKELEY, Calif. In what has become a closely watched event in the world of high-performance computing, the 23rd edition of the TOP500 list of the world's fastest supercomputers was released today (June 23, 2004) at the International Supercomputer Conference in Heidelberg, Germany.

  5. TOP500 Supercomputers for November 2004

    SciTech Connect

    Strohmaier, Erich; Meuer, Hans W.; Dongarra, Jack; Simon, Horst D.

    2004-11-08

    24th Edition of TOP500 List of World's Fastest Supercomputers Released: DOE/IBM BlueGene/L and NASA/SGI's Columbia gain Top Positions MANNHEIM, Germany; KNOXVILLE, Tenn.; BERKELEY, Calif. In what has become a closely watched event in the world of high-performance computing, the 24th edition of the TOP500 list of the worlds fastest supercomputers was released today (November 8, 2004) at the SC2004 Conference in Pittsburgh, Pa.

  6. TOP500 Supercomputers for June 2005

    SciTech Connect

    Strohmaier, Erich; Meuer, Hans W.; Dongarra, Jack; Simon, Horst D.

    2005-06-22

    25th Edition of TOP500 List of World's Fastest Supercomputers Released: DOE/L LNL BlueGene/L and IBM gain Top Positions MANNHEIM, Germany; KNOXVILLE, Tenn.; BERKELEY, Calif. In what has become a closely watched event in the world of high-performance computing, the 25th edition of the TOP500 list of the world's fastest supercomputers was released today (June 22, 2005) at the 20th International Supercomputing Conference (ISC2005) in Heidelberg Germany.

  7. Top quark mass measurements at CDF

    SciTech Connect

    Maki, Tuula; /Helsinki U. /Helsinki Inst. of Phys.

    2007-10-01

    The top quark mass is interesting both as a fundamental parameter of the standard model as well as an important input to precision electroweak tests. The CDF Collaboration has measured the top quark mass with high precision in all decay channels with complementary methods. A combination of the results from CDF gives a top quark mass of 170.5{+-}1.3(stat.){+-}1.8(syst.) GeV/c{sup 2}.

  8. Top quark physics at the Tevatron

    SciTech Connect

    D. Gerdes

    2004-01-28

    Precision studies of the top quark are a prime goal of the Run II physics program at the Fermilab Tevatron. Since the start of Run II in early 2002, the CDF and D0 experiments have analyzed approximately 100 pb{sup -1} of data and have re-established the top quark signal. In this article the author summarizes recent measurements of the top production cross section and mass.

  9. Boat Deck, Cabin Deck, Bridge Deck, Flat House Top, Stage ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Boat Deck, Cabin Deck, Bridge Deck, Flat House Top, Stage Top, Mast House Top, Upper Deck, Flat House Tops, Forecastle Deck, Main Deck - American Racer, Suisun Bay Reserve Fleet, Benicia, Solano County, CA

  10. Top Quark Production Asymmetries AFBt and AFBl

    DOE PAGESBeta

    Berger, Edmond L.; Cao, Qing-Hong; Chen, Chuan-Ren; Yu, Jiang-Hao; Zhang, Hao

    2012-02-14

    A large forward-backward asymmetry is seen in both the top quark rapidity distribution AFBt and in the rapidity distribution of charged leptons AFBl from top quarks produced at the Tevatron. We study the kinematic and dynamic aspects of the relationship of the two observables arising from the spin correlation between the charged lepton and the top quark with different polarization states. We emphasize the value of both measurements, and we conclude that a new physics model which produces more right-handed than left-handed top quarks is favored by the present data.

  11. Top Quark Physics at the CDF Experiment

    SciTech Connect

    Stelzer, Bernd; Collaboration, for the CDF

    2010-07-01

    Fermilab's Tevatron accelerator is recently performing at record luminosities that enables a program systematically addressing the physics of top quarks. The CDF collaboration has analyzed up to 5 fb{sup -1} of proton anti-proton collisions from the Tevatron at a center of mass energy of 1.96 TeV. The large datasets available allow to push top quark measurements to higher and higher precision and have lead to the recent observation of electroweak single top quark production at the Tevatron. This article reviews recent results on top quark physics from the CDF experiment.

  12. Single Top Quarks at the Tevatron

    SciTech Connect

    Heinson, Ann P.; /UC, Riverside

    2008-09-01

    After many years searching for electroweak production of top quarks, the Tevatron collider experiments have now moved from obtaining first evidence for single top quark production to an impressive array of measurements that test the standard model in several directions. This paper describes measurements of the single top quark cross sections, limits set on the CKM matrix element |Vtb|, searches for production of single top quarks produced via flavor-changing neutral currents and from heavy W-prime and H+ boson resonances, and studies of anomalous Wtb couplings. It concludes with projections for future expected significance as the analyzed datasets grow.

  13. Top-of-Rail lubricant

    SciTech Connect

    Alzoubi, M. F.; Fenske, G. R.; Erck, R. A.; Boparai, A. S.

    2000-07-14

    Analysis of the volatile and semivolatile fractions collected after use of the TOR lubricant indicated that other than contaminants in the collection laboratory, no compounds on the EPA's Target Compound Lists (Tables 2 and 5) were detected in these fractions. The data of these qualitative analyses, given in the various tables in the text, indicate only the relative amounts of the tentatively identified compounds. The authors recommend that quantitative analysis be performed on the volatile and semivolatile fractions to allow confirmation of the tentatively identified compounds and to obtain absolute amounts of the detected compounds. Additionally, the semivolatile fraction should be analyzed by liquid chromatography/mass spectrometry to identify compounds that are not chromatographable under the temperature program used for determination of semivolatile compounds. Introducing the top-of-rail (TOR) lubricant into the wheel/rail interface results in a reduction of almost 60% of lateral friction force over the forces encountered under dry conditions. This reveals good potential for energy savings, as well as wear reduction, for railroad companies. In TOR lubrication, an increase in the angle of attack and axle load results in increased lateral friction and rate of lubricant consumption. The most efficient TOR lubricant quantity to be used in the wheel/rail interface must be calculated precisely according to the number of cars, axle loads, train speed, and angle of attack.

  14. MHD Integrated Topping Cycle Project

    SciTech Connect

    Not Available

    1992-02-01

    This fourteenth quarterly technical progress report of the MHD Integrated Topping Cycle Project presents the accomplishments during the period November 1, 1990 to January 31, 1991. Testing of the High Pressure Cooling Subsystem electrical isolator was completed. The PEEK material successfully passed the high temperature, high pressure duration tests (50 hours). The Combustion Subsystem drawings were CADAM released. The procurement process is in progress. An equipment specification and RFP were prepared for the new Low Pressure Cooling System (LPCS) and released for quotation. Work has been conducted on confirmation tests leading to final gas-side designs and studies to assist in channel fabrication.The final cathode gas-side design and the proposed gas-side designs of the anode and sidewall are presented. Anode confirmation tests and related analyses of anode wear mechanisms used in the selection of the proposed anode design are presented. Sidewall confirmation tests, which were used to select the proposed gas-side design, were conducted. The design for the full scale CDIF system was completed. A test program was initiated to investigate the practicality of using Avco current controls for current consolidation in the power takeoff (PTO) regions and to determine the cause of past current consolidation failures. Another important activity was the installation of 1A4-style coupons in the 1A1 channel. A description of the coupons and their location with 1A1 channel is presented herein.

  15. Creation of Functional Micro/Nano Systems through Top-down and Bottom-up Approaches

    PubMed Central

    Wong, Tak-Sing; Brough, Branden; Ho, Chih-Ming

    2009-01-01

    Mimicking nature’s approach in creating devices with similar functional complexity is one of the ultimate goals of scientists and engineers. The remarkable elegance of these naturally evolved structures originates from bottom-up self-assembly processes. The seamless integration of top-down fabrication and bottom-up synthesis is the challenge for achieving intricate artificial systems. In this paper, technologies necessary for guided bottom-up assembly such as molecular manipulation, molecular binding, and the self assembling of molecules will be reviewed. In addition, the current progress of synthesizing mechanical devices through top-down and bottom-up approaches will be discussed. PMID:19382535

  16. Tools for top physics at D0

    SciTech Connect

    Harel, Amnon

    2008-07-01

    Top quark measurements rely on the jet energy calibration and often on b-quark identification. We discuss these and other tools and how they apply to top quark analyses at D0. In particular some of the nuances that result from D0's data driven approach to these issues are presented.

  17. Top Quark Pair Production at the Tevatron

    SciTech Connect

    Nielsen, Jason

    2005-05-17

    The measurement of the top quark pair production crosssection inproton-antiproton collisions at 1.96 TeV is a test ofquantumchromodynamics and could potentially be sensitive to newphysics beyondthe standard model. I report on the latest t-tbarcross section resultsfrom the CDF and DZero experiments in various finalstate topologies whicharise from decays of top quark pairs.

  18. Teaching Top-Down Problem Solving.

    ERIC Educational Resources Information Center

    Patrick, Charles

    Top-down problem solving is a methodical approach to obtaining real solutions for open-ended problems common in the realms of engineering and science. The technique provides a means for logically understanding a problem prior to attempting a solution. Steps in the top-down problem-solving method include the following: (1) identifying a need; (2)…

  19. Pinch Experiments in a Table Top Generator

    SciTech Connect

    Pavez, Cristian; Moreno, Jose; Soto, Leopoldo; Tarifeno, Ariel

    2009-01-21

    The design and construction of a table top multipurpose capacitor bank of hundred of Joules and hundred of kiloAmperes conceived to be used in small scale Z-pinch experiments is reported. A recent result on a Z-pinch gas embedded discharge using hollow conical electrodes done in a similar table top generator is also presented.

  20. 49 CFR 236.779 - Plate, top.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Plate, top. 236.779 Section 236.779 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF... OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Definitions § 236.779 Plate, top....

  1. 49 CFR 236.779 - Plate, top.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Plate, top. 236.779 Section 236.779 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF... OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Definitions § 236.779 Plate, top....

  2. 49 CFR 236.779 - Plate, top.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Plate, top. 236.779 Section 236.779 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF... OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Definitions § 236.779 Plate, top....

  3. 49 CFR 236.779 - Plate, top.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Plate, top. 236.779 Section 236.779 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF... OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Definitions § 236.779 Plate, top....

  4. 49 CFR 236.779 - Plate, top.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Plate, top. 236.779 Section 236.779 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF... OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Definitions § 236.779 Plate, top....

  5. Search for top quark at Fermilab Collider

    SciTech Connect

    Sliwa, K.; The CDF Collaboration

    1991-10-01

    The status of a search for the top quark with Collider Detector at Fermilab (CDF), based on a data sample recorded during the 1988--1989 run is presented. The plans for the next Fermilab Collider run in 1992--1993 and the prospects of discovering the top quark are discussed. 19 refs., 4 figs., 2 tabs.

  6. Race to Top Draws out New Suitors

    ERIC Educational Resources Information Center

    McNeil, Michele

    2012-01-01

    The list of 61 finalists for the latest Race to the Top competition shows that the U.S. Department of Education was successful in enticing high-scoring applications from districts in rural America and in states that had not shared in the Race to the Top bounty before. But whether the ultimate winners, which will be announced this month, will be…

  7. Technology Review: WBT Systems' TopClass.

    ERIC Educational Resources Information Center

    Szabo, Sharon

    1998-01-01

    Discusses TopClass, a Web-based tool and delivery system used for online courses, and its use at Schoolcraft College in Michigan. TopClass offers many benefits, including a self-contained management system, secured access, user-friendly instructions for coursework area creation, e-mail, bulletin boards, a secured testing mechanism and student…

  8. Controlling Severe Curly Top in Sugarbeets

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Controlling curly top in sugarbeet has been industry priority in the western United States since the 1920s. Curly top is a virus disease that is vectored by the beet leafhopper. If the beet leafhopper moves into commercial fields early in the season, virus is more likely to be transmitted to sugar...

  9. The Gender Gap in Top Corporate Jobs.

    ERIC Educational Resources Information Center

    Bertrand, Marianne; Hallock, Kevin F.

    2001-01-01

    Women, about 2% of a sample of top executives, earned about 45% less than men. Three-fourths of the gap may be explained by women managing smaller companies and being less likely to be chair/president. Gender segregation or unequal promotion may play a role. Between 1992-1997, women nearly tripled their representation among top executives, mostly…

  10. Review of Top Quark Physics Results

    SciTech Connect

    Kehoe, R.; Narain, M.; Kumar, A.

    2007-12-01

    As the heaviest known fundamental particle, the top quark has taken a central role in the study of fundamental interactions. Production of top quarks in pairs provides an important probe of strong interactions. The top quark mass is a key fundamental parameter which places a valuable constraint on the Higgs boson mass and electroweak symmetry breaking. Observations of the relative rates and kinematics of top quark final states constrain potential new physics. In many cases, the tests available with study of the top quark are both critical and unique. Large increases in data samples from the Fermilab Tevatron have been coupled with major improvements in experimental techniques to produce many new precision measurements of the top quark. The first direct evidence for electroweak production of top quarks has been obtained, with a resulting direct determination of V{sub tb}. Several of the properties of the top quark have been measured. Progress has also been made in obtaining improved limits on potential anomalous production and decay mechanisms. This review presents an overview of recent theoretical and experimental developments in this field. We also provide a brief discussion of the implications for further efforts.

  11. Top-hat random fiber Bragg grating.

    PubMed

    Yin, Hongwei; Gbadebo, Adenowo; Turitsyna, Elena G

    2015-08-01

    We examined the possibility of using noise or pseudo-random variations of the refractive index in the design of fiber Bragg gratings (FBGs). We demonstrated theoretically and experimentally that top-hat FBGs may be designed and fabricated using this approach. The reflectivity of the fabricated top-hat FBG matches quite well with that of the designed one. PMID:26258365

  12. Odd top partners at the LHC

    NASA Astrophysics Data System (ADS)

    Anandakrishnan, Archana; Collins, Jack H.; Farina, Marco; Kuflik, Eric; Perelstein, Maxim

    2016-04-01

    LHC searches for fermionic top partners T focus on three decay topologies: T →b W , T →t Z , and T →t h . However, top partners may carry new conserved quantum numbers that forbid these decays. The simplest possibility is a conserved parity, under which the top partner is odd and all SM states are even. In this case, decays of top partners may involve new particle-odd scalars, leading to signal topologies more commonly associated with supersymmetry, either with or without R -parity conservation. We study a simplified model in which this possibility is realized, and estimate the bounds on the top partner mass in this model implied by LHC searches for supersymmetry. We find that the bounds can be significantly weaker than in the conventional top partner decay scenario. For example, if the new parity is exact, a 500 GeV top partner is allowed as long as the lightest parity-odd scalar mass is between 325 and 500 GeV. The lower allowed top partner mass reduces the need for fine-tuning in the Higgs mass parameter, compared to the conventional decay scenario. We also present an explicit model, the oddest little Higgs, which exhibits this phenomenology.

  13. Transport properties of asymmetric-top molecules.

    PubMed

    Dickinson, A S; Hellmann, R; Bich, E; Vogel, E

    2007-06-14

    Kinetic theory of gases is extended from linear molecules to asymmetric tops. The integration over the velocity of the centre of mass is carried out explicitly and the results are expressed in a form suitable for classical evaluation. These results can also be employed for spherical and symmetric tops. PMID:17538728

  14. Top Managerial Prestige and Organizational Bankruptcy.

    ERIC Educational Resources Information Center

    D'Aveni, Richard

    1990-01-01

    Suggests that bankruptcy occurs when creditors withdraw their support from a firm's top management team. Five characteristics measuring the relative status of top teams tested on a sample of 57 large bankrupt firms and 57 matched firms revealed that membership in political elites and board connections were negatively associated with bankruptcy.…

  15. World average top-quark mass

    SciTech Connect

    Glenzinski, D.; /Fermilab

    2008-01-01

    This paper summarizes a talk given at the Top2008 Workshop at La Biodola, Isola d Elba, Italy. The status of the world average top-quark mass is discussed. Some comments about the challanges facing the experiments in order to further improve the precision are offered.

  16. The Sakai Spinner: A Paperclip Top

    ERIC Educational Resources Information Center

    Corrao, Christian T.

    2014-01-01

    A challenge: Can you create a stable top from a single paper clip? Several interesting solutions to this problem were provided by Takao Sakai from Japan, the requirement of each being that the center of gravity be located on the vertical y-axis at the center of the top. In the simplest configuration, we see that there exists a single angle ?…

  17. Top 12 Web Resources for 2012

    ERIC Educational Resources Information Center

    Gonzales, Lisa; Vodicka, Devin

    2012-01-01

    In this article, the authors describe some of the top websites recommended by colleagues for the Association of California School Administrators. The Top 12 for 2012 are: (1) Facebook (facebook.com); (2) Twitter (twitter.com); (3) Tungle (tungle.me); (4) FCMAT (fcmat.org); (5) YouSendIt (yousendit.com); (6) Slideshare (slideshare.net); (7) QR…

  18. TOP500 Supercomputers for June 2002

    SciTech Connect

    Strohmaier, Erich; Meuer, Hans W.; Dongarra, Jack; Simon, Horst D.

    2002-06-20

    19th Edition of TOP500 List of World's Fastest Supercomputers Released MANNHEIM, Germany; KNOXVILLE, Tenn.;&BERKELEY, Calif. In what has become a much-anticipated event in the world of high-performance computing, the 19th edition of the TOP500 list of the worlds fastest supercomputers was released today (June 20, 2002). The recently installed Earth Simulator supercomputer at the Earth Simulator Center in Yokohama, Japan, is as expected the clear new number 1. Its performance of 35.86 Tflop/s (trillions of calculations per second) running the Linpack benchmark is almost five times higher than the performance of the now No.2 IBM ASCI White system at Lawrence Livermore National Laboratory (7.2 Tflop/s). This powerful leap frogging to the top by a system so much faster than the previous top system is unparalleled in the history of the TOP500.

  19. Protein Identification Using Top-Down

    SciTech Connect

    Liu, Xiaowen; Sirotkin, Yakov; Shen, Yufeng; Anderson, Gordon A.; Tsai, Yi-Hsuan S.; Ting, Ying S.; Goodlett, David R.; Smith, Richard D.; Bafna, Vineet; Pevzner, Pavel A.

    2012-06-01

    In the last two years, due to advances in protein separation and mass spectrometry, top-down mass spectrometry moved from analyzing single proteins to analyzing complex samples and identifying hundreds and even thousands of proteins. However, computational tools for database search of top-down spectra against protein databases are still in infancy. We describe MS-Align+, a fast algorithm for top-down protein identification based on spectral alignment that enables searches for unexpected post-translational modifications (PTMs). We also propose a method for evaluating statistical significance of top-down protein identifications and further benchmark MS-Align+ along with PIITA, ProSightPTM and SEQUEST, which were previously used for top-down MS/MS database searches. We demonstrate that MS-Align+ and PIITA significantly increase the number of identified proteins as compared to ProSightPTM and SEQUEST.

  20. Top Mass Measurements at the Tevatron

    SciTech Connect

    Potamianos, Karolos; /Purdue U.

    2012-01-01

    First observed in 1995, the top quark is the third-generation up-type quark of the standard model of particle physics (SM). The CDF and D0 collaborations have analyzed many t{bar t} events produced by the Tevatron collider, studying many properties of the top quark. Among these, the mass of the top quark is a fundamental parameter of the SM, since its value constrains the mass of the yet to be observed Higgs boson. The analyzed events were used to measure the mass of the top quark m{sub t} {approx_equal} 173.2 GeV/c{sup 2} with an uncertainty of less than 1 GeV/c{sup 2}. We report on the latest top mass measurements at the Tevatron, using up to 6 fb{sup -1} of data for each experiment.

  1. Thermionic topping of electric power plants

    NASA Technical Reports Server (NTRS)

    Britt, E. J.; Fitzpatrick, G. O.; Rasor, N. S.

    1975-01-01

    The most likely use of thermionic conversion is in the form of a topping cycle combined with a steam-turbogenerator plant. A specific reference system is chosen in which the thermionic topping cycle occurs in thermionic heat exchangers referred to as large, modular thermionic units to which heat is transferred from a separate heat source and which reject their heat to a conventional steam turboelectric system. Results of analysis show that the performance and cost criteria for practical thermionic topping of large electric power plants are well within the reach of demonstrated and foreseeable converter capabilities. Thermionic topping has many significant advantages over unconventional cycles proposed for topping applications, including level of demonstrated and projected performance and lifetime, development time, and design simplicity.

  2. D{O} top quark mass analysis

    SciTech Connect

    Strovink, M.

    1995-07-01

    Based on (44-48 pb{sup -1}) of lepton + jets data, we review D0`s initial analysis of the top quark mass. The result, M{sub top} = 199 {+-} 19/21 (stat.) {+-} 22 (syst.) GeV/c{sup 2}, is insensitive to background normalization. The errors are based on ISAJET top Monte Carlo, with its more severe gluon radiation, and allow for ISAJET/HERWIG differences. Good progress is being made in reducing the systematic error. We present a new study based on two-dimensional distributions of reconstructed top quark vs. dijet mass. With 98.7% confidence we observe a peak in the top mass - dijet mass plane. The peak and its projections are similar both in shape and magnitude to expectations based on the decay sequence 1 {yields} bW, W {yields} jj.

  3. Intracellular delivery of top-down fabricated tunable nano-plasmonic resonators

    NASA Astrophysics Data System (ADS)

    Ota, Sadao; Wang, Sheng; Ryu, Jongeun; Wang, Yuan; Chen, Yong; Zhang, Xiang

    2013-10-01

    Engineered plasmonic structures fabricated using top-down technologies have demonstrated huge enhancements in the optical response of molecules, including Raman scattering. However, providing a sufficient number of such top-down fabricated nanostructures in solution has been a nontrivial task which has limited their potential in intracellular applications. Here we report the development of a protocol for the intracellular delivery of tunable nanoplasmonic resonators fabricated via scalable top-down techniques. This offers excellent possibilities towards the real-time parallel optical detection of intracellular molecular events.Engineered plasmonic structures fabricated using top-down technologies have demonstrated huge enhancements in the optical response of molecules, including Raman scattering. However, providing a sufficient number of such top-down fabricated nanostructures in solution has been a nontrivial task which has limited their potential in intracellular applications. Here we report the development of a protocol for the intracellular delivery of tunable nanoplasmonic resonators fabricated via scalable top-down techniques. This offers excellent possibilities towards the real-time parallel optical detection of intracellular molecular events. Electronic supplementary information (ESI) available: Details of fabrication methods are described. See DOI: 10.1039/c3nr02910g

  4. Discovery of single top quark production

    SciTech Connect

    Gillberg, Dag

    2009-04-01

    The top quark is by far the heaviest known fundamental particle with a mass nearing that of a gold atom. Because of this strikingly high mass, the top quark has several unique properties and might play an important role in electroweak symmetry breaking - the mechanism that gives all elementary particles mass. Creating top quarks requires access to very high energy collisions, and at present only the Tevatron collider at Fermilab is capable of reaching these energies. Until now, top quarks have only been observed produced in pairs via the strong interaction. At hadron colliders, it should also be possible to produce single top quarks via the electroweak interaction. Studies of single top quark production provide opportunities to measure the top quark spin, how top quarks mix with other quarks, and to look for new physics beyond the standard model. Because of these interesting properties, scientists have been looking for single top quarks for more than 15 years. This thesis presents the first discovery of single top quark production. An analysis is performed using 2.3 fb-1 of data recorded by the D0 detector at the Fermilab Tevatron Collider at centre-of-mass energy √s = 1.96 TeV. Boosted decision trees are used to isolate the single top signal from background, and the single top cross section is measured to be σ(p$\\bar{p}$ → tb + X, tqb + X) = 3.74-0.74+0.95 pb. Using the same analysis, a measurement of the amplitude of the CKM matrix element Vtb, governing how top and b quarks mix, is also performed. The measurement yields: |V{sub tb}|f1L| = 1.05 -0.12+0.13, where f1L is the left-handed Wtb coupling. The separation of signal from background is improved by combining the boosted decision trees with two other multivariate techniques. A new cross section measurement is performed, and the significance for the excess over the predicted background exceeds 5

  5. Study of the top reconstruction in top-partner events at the LHC

    SciTech Connect

    Takeuchi, Michihisa

    2008-11-23

    In the Littlest Higgs model with T-parity (LHT), top-partners (T{sub -}) are produced in pairs at the Large Hadron Collider (LHC). Each top-partner decays into a top quark (t) and the lightest T-odd gauge partner A{sub H}. We demonstrate reconstruction of the tt-bar system decaying hadronically and measurement of the top-partner mass from the m{sub T2} distribution. A top quark from a T{sub -} decay is polarized, and we discuss the effect of this polarization on the decay distributions.

  6. The Top Quark, QCD, And New Physics.

    DOE R&D Accomplishments Database

    Dawson, S.

    2002-06-01

    The role of the top quark in completing the Standard Model quark sector is reviewed, along with a discussion of production, decay, and theoretical restrictions on the top quark properties. Particular attention is paid to the top quark as a laboratory for perturbative QCD. As examples of the relevance of QCD corrections in the top quark sector, the calculation of e{sup+}e{sup -}+ t{bar t} at next-to-leading-order QCD using the phase space slicing algorithm and the implications of a precision measurement of the top quark mass are discussed in detail. The associated production of a t{bar t} pair and a Higgs boson in either e{sup+}e{sup -} or hadronic collisions is presented at next-to-leading-order QCD and its importance for a measurement of the top quark Yulrawa coupling emphasized. Implications of the heavy top quark mass for model builders are briefly examined, with the minimal supersymmetric Standard Model and topcolor discussed as specific examples.

  7. Deuterium in North Atlantic storm tops

    NASA Technical Reports Server (NTRS)

    Smith, Ronald B.

    1992-01-01

    During the ERICA project in 1989, ice crystals were collected from the tops of two winter storms and one broad cirrus cloud. Deuterium concentration in the storm ice samples, together with a model of isotope fractionation, are used to determine the temperature where the ice was formed. Knowledge of the ice formation temperature allows us to determine whether the ice has fallen or been lofted to the altitude of collection. In both storms, the estimated fall distance decreases upward. In the 21 January storm, the fall distance decreases to zero at the cloud top. In the 23 January storm, the fall distance decreases to zero at a point 2 km below the cloud top and appears to become negative above, indicating lofted ice. Cloud particle data from the cloud tops show an ice-to-vapor ratio greater than one and indicate the presence of particles with small terminal velocities; both observations support the idea of ice lofting. The satellite-derived cloud tops lie well below the actual cloud top (e.g., 2.5 km below on 23 January), indicating that the lofted ice in winter storms may not be detectable from space using IR radiance techniques. A comparison of deuterium in cloud-top ice and clear-air vapor suggests that even in winter, when vertical air motions are relatively weak, lofted ice crystals are the dominant source of water vapor in the upper troposphere.

  8. THE TOP QUARK, QCD, AND NEW PHYSICS.

    SciTech Connect

    DAWSON,S.

    2002-06-01

    The role of the top quark in completing the Standard Model quark sector is reviewed, along with a discussion of production, decay, and theoretical restrictions on the top quark properties. Particular attention is paid to the top quark as a laboratory for perturbative QCD. As examples of the relevance of QCD corrections in the top quark sector, the calculation of e{sup +}e{sup -} + t{bar t} at next-to-leading-order QCD using the phase space slicing algorithm and the implications of a precision measurement of the top quark mass are discussed in detail. The associated production of a t{bar t} pair and a Higgs boson in either e{sup +}e{sup -} or hadronic collisions is presented at next-to-leading-order QCD and its importance for a measurement of the top quark Yulrawa coupling emphasized. Implications of the heavy top quark mass for model builders are briefly examined, with the minimal supersymmetric Standard Model and topcolor discussed as specific examples.

  9. Top quark mass measurement at the Tevatron

    SciTech Connect

    Guimaraes da Costa, Joao; /Harvard U.

    2004-12-01

    The authors report on the latest experimental measurements of the top quark mass by the CDF and D0 Collaborations at the Fermilab Tevatron. They present a new top mass measurement using the t{bar t} events collected by the D0 Collaboration in Run I between 1994 and 1996. This result is combined with previous measurements to yield a new world top mass average. They also describe several preliminary results using up to 193 pb{sup -1} of t{bar t} events produced in {bar p}p collisions at {radical}s = 1.96 TeV during the Run II of the Tevatron.

  10. Single Top Production at the Tevatron

    SciTech Connect

    Wu, Zhenbin; /Baylor U.

    2012-05-01

    We present recent results of single top quark production in the lepton plus jet final state, performed by the CDF and D0 collaborations based on 7.5 and 5.4 fb{sup -1} of p{bar p} collision data collected at {radical}s = 1.96 TeV from the Fermilab Tevatron collider. Multivariate techniques are used to separate the single top signal from the backgrounds. Both collaborations present measurements of the single top quark cross section and the CKM matrix element |V{sub tb}|. A search for anomalous Wtb coupling from D0 is also presented.

  11. Top Quark Production at the Tevatron

    SciTech Connect

    Mietlicki, David J.

    2011-12-01

    The top quark is the most recently discovered of the standard model quarks, and because of its very large mass, studies of the top quark and its interactions are important both as tests of the standard model and searches for new phenomena. In this document, recent results of analyses of top quark production, via both the electroweak and strong interactions, from the CDF and D0 experiments are presented. The results included here utilize a dataset corresponding to up to 6 fb{sup -1} of integrated luminosity, slightly more than half of the dataset recorded by each experiment before the Tevatron was shutdown in September 2011.

  12. Precision Determination of the Top Quark Mass

    SciTech Connect

    Movilla Fernandez, Pedro A.; /LBL, Berkeley

    2007-05-01

    The CDF and D0 collaborations have updated their measurements of the mass of the top quark using proton-antiproton collisions at {radical}s = 1.96 TeV produced at the Tevatron. The uncertainties in each of the top-antitop decay channels have been reduced. The new Tevatron average for the mass of the top quark based on about 1 fb{sup -1} of data per experiment is 170.9 {+-} 1.8 GeV/c{sup 2}.

  13. Top quark properties from the Tevatron

    SciTech Connect

    Klute, Markus; /MIT, LNS

    2006-05-01

    This report describes latest measurements and studies of top quark properties from the Tevatron in Run II with an integrated luminosity of up to 750 pb{sup -1}. Due to its large mass of about 172 GeV/c{sup 2}, the top quark provides a unique environment for tests of the Standard Model and is believed to yield sensitivity to new physics beyond the Standard Model. With data samples of close to 1 fb{sup -1} the CDF and D0 collaborations at the Tevatron enter a new area of precision top quark measurements.

  14. The search for top at CDF

    SciTech Connect

    Liss, T.M.; CDF Collaboration

    1991-08-01

    We present results on the search for the top quark in {bar p}p collisions at {radical}s = 1.8 TeV. The data sample collected during the 1988--89 run with the Collider Detector at Fermilab (CDF) includes more than 4 pb{sup {minus}1}. We report here on an extension of previously published searches for the top quark in electron + jets and the dilepton channel electron-muon. The 95% confidence level limit on the top mass is 89 GeV/c{sup 2}.

  15. High index top layer for multimaterial coatings

    NASA Astrophysics Data System (ADS)

    Steinlechner, Jessica; Martin, Iain W.

    2016-05-01

    For application in future cryogenically cooled gravitational wave detectors, the thermal noise of low absorbing mirror coatings has to be reduced. The development of low mechanical and optical loss materials is challenging, but thermal noise reduction can be significantly supported by using a multimaterial coating design. We analyze the possible improvement of the total (optical and mechanical) loss of a three-material based coating obtained by optimizing the properties of the top layer of the coating stack. A top-layer material with sufficiently high refractive index could have a significantly higher optical and mechanical loss than currently used tantala, while still enabling reduction of the total coating loss. Restrictions on possible top-layer material properties are made, and the option of a crystalline top layer is discussed.

  16. The Top 100: Interpreting the Data.

    ERIC Educational Resources Information Center

    Borden, Victor M. H.

    1999-01-01

    The sources and structure of data reported in the annual "Top 100" list of colleges and universities conferring the highest numbers of degrees to students of color are described, including the way in which various student categories are reported. (MSE)

  17. Top quark compositeness: Feasibility and implications

    SciTech Connect

    Pomarol, Alex; Serra, Javi

    2008-10-01

    In models of electroweak symmetry breaking in which the standard model fermions get their masses by mixing with composite states, it is natural to expect the top quark to show properties of compositeness. We study the phenomenological viability of having a mostly composite top. The strongest constraints are shown to mainly come from one-loop contributions to the T parameter. Nevertheless, the presence of light custodial partners weakens these bounds, allowing in certain cases for a high degree of top compositeness. We find regions in the parameter space in which the T parameter receives moderate positive contributions, favoring the electroweak fit of this type of model. We also study the implications of having a composite top at the LHC, focusing on the process pp{yields}tttt(bb) whose cross section is enhanced at high energies.

  18. Wind Energy Program: Top 10 Program Accomplishments

    SciTech Connect

    2009-01-18

    Brochure on the top accomplishments of the Wind Energy Program, including the development of large wind machines, small machines for the residential market, wind tunnel testing, computer codes for modeling wind systems, high definition wind maps, and successful collaborations.

  19. Best of "Earth As Art" -- Top Five

    NASA Video Gallery

    Counting down the Top Five Earth As Art images, as voted on by the public. Landsat has been collecting data of the Earth's surface since 1972. Some of the images are visually striking, and they hav...

  20. Top and higgs physics at the Tevatron

    SciTech Connect

    Pierre Savard

    2002-12-23

    We present a summary of our experimental understanding of the top quark and discuss the significant improvements expected in Run II at the Fermilab Tevatron Collider. We also discuss prospects for a Higgs boson discovery at the Tevatron.

  1. Dark Decay of the Top Quark

    SciTech Connect

    Kong, Kyoungchul; Lee, Hye-Sung; Park, Myeonghun

    2014-04-01

    We suggest top quark decays as a venue to search for light dark force carriers. The top quark is the heaviest particle in the standard model whose decays are relatively poorly measured, allowing sufficient room for exotic decay modes from new physics. A very light (GeV scale) dark gauge boson (Z') is a recently highlighted hypothetical particle that can address some astrophysical anomalies as well as the 3.6sigma deviation in the muon g-2 measurement. We present and study a possible scenario that top quark decays as t-->bW+Z's. This is the same as the dominant top quark decay (t-->bW) accompanied by one or multiple dark force carriers. The Z' can be easily boosted, and it can decay into highly collimated leptons (lepton-jet) with large branching ratio. We discuss the implications for the Large Hadron Collider experiments including the analysis based on the lepton-jets.

  2. Top Quark Physics at the Tevatron

    SciTech Connect

    Jung, Andreas W.

    2015-05-21

    An overview of recent top quark measurements using the full Run II data set of CDF or D0 at the Tevatron is presented. Results are complementary to the ones at the LHC. Recent measurements of the production cross section of top quarks in strong and electroweak production and of top quark production asymmetries are presented. The latter includes the measurement of the tt-bar production asymmetry by D0 in the dilepton decay channel. Within their uncertainties the results from all these measurements agree with their respective Standard Model expectation. Finally latest updates on measurements of the top quark mass are discussed, which at the time of the conference are the most precise determinations.

  3. Review of recent top quark measurements

    SciTech Connect

    Heinson, A.P.; /UC, Riverside

    2004-11-01

    At the Tevatron Collider at Fermilab, a large number of top quarks have been produced in the ongoing run. The CDF and D0 collaborations have made first measurements of the t{bar t} cross section in several decay channels, and have measured the top quark mass. In addition, they have set new limits on the cross sections for single top quark production, and have started to measure some of the properties of the top quark via studies of its decays. This paper summarizes the status of these measurements and discusses where they are heading in the next few years. The paper is based on a talk I gave at the Rencontres du Vietnam in Hanoi, August 2004; the results have been updated to show the latest values and new measurements.

  4. Dark decay of the top quark

    SciTech Connect

    Kong, Kyoungchul; Lee, Hye -Sung; Park, Myeonghun

    2014-04-01

    We suggest top quark decays as a venue to search for light dark force carriers. Top quark is the heaviest particle in the standard model whose decays are relatively poorly measured, allowing sufficient room for exotic decay modes from new physics. A very light (GeV scale) dark gauge boson (Z') is a recently highlighted hypothetical particle that can address some astrophysical anomalies as well as the 3.6 σ deviation in the muon g-2 measurement. We present and study a possible scenario that top quark decays as t → b W + Z's. This is the same as the dominant top quark decay (t → b W) accompanied by one or multiple dark force carriers. The Z' can be easily boosted, and it can decay into highly collimated leptons (lepton-jet) with large branching ratio. In addition, we discuss the implications for the Large Hadron Collider experiments including the analysis based on the lepton-jets.

  5. Higgs Effects in Top Quark Pair Production

    SciTech Connect

    Kuhn, J.H.

    2003-06-13

    Top quark production in p{bar p} and e{sup +}e{sup -} collisions is enhanced by the exchange of a Higgs boson. The enhancement factors are calculated in the threshold region using the Greens function method.

  6. Top Ten Technology Breakthroughs for Schools.

    ERIC Educational Resources Information Center

    Bateman, Bill; Crystal, Jerry; Davidson, Hall; Holzberg, Carol S.; McIntire, Todd; McLester, Susan; Ohler, Jason; Rose, Ray; Shields, Jean; Warlick, David

    2001-01-01

    Contributors discuss the top ten technologies that allow for thinking in new and innovative ways about the concept of "school": virtual learning; wireless networking; collaboration tools; digital video; Application Service Providers; handheld devices; optical networking; videoconferencing; XML; and simulations. (AEF)

  7. Tools for top physics at CDF

    SciTech Connect

    Palencia, E.; /Fermilab

    2008-07-01

    The authors describe here the different tools used for top physics analysis in the CDF Collaboration. In particular, they discuss how the jet energy scale, lepton identification, b tagging algorithms and the neural networks help to improve the signal to background ratio of the top sample in some cases and to reduce the dominant uncertainties in other. Results using each one of these tools are also presented.

  8. The Discovery of the Top Quark

    DOE R&D Accomplishments Database

    Sinervo, P.K.

    1995-12-01

    The top quark and the Higgs boson are the heaviest elementary particles predicted by the standard model. The four lightest quark flavours, the up, down, strange and charm quarks, were well-established by the mid-1970's. The discovery in 1977 of the {Tau} resonances, a new family of massive hadrons, required the introduction of the fifth quark flavour. Experimental and theoretical studies have indicated that this quark also has a heavier partner, the top quark.

  9. Measurements and searches with top quarks

    SciTech Connect

    Peters, Reinhild Yvonne; /Wuppertal U.

    2008-10-01

    In 1995 the last missing member of the known families of quarks, the top quark, was discovered by the CDF and D0 experiments at the Tevatron, a proton-antiproton collider at Fermilab near Chicago. Until today, the Tevatron is the only place where top quarks can be produced. The determination of top quark production and properties is crucial to understand the Standard Model of particle physics and beyond. The most striking property of the top quark is its mass--of the order of the mass of a gold atom and close to the electroweak scale--making the top quark not only interesting in itself but also as a window to new physics. Due to the high mass, much higher than of any other known fermion, it is expected that the top quark plays an important role in electroweak symmetry breaking, which is the most prominent candidate to explain the mass of particles. In the Standard Model, electroweak symmetry breaking is induced by one Higgs field, producing one additional physical particle, the Higgs boson. Although various searches have been performed, for example at the Large Electron Positron Collider (LEP), no evidence for the Higgs boson could yet be found in any experiment. At the Tevatron, multiple searches for the last missing particle of the Standard Model are ongoing with ever higher statistics and improved analysis techniques. The exclusion or verification of the Higgs boson can only be achieved by combining many techniques and many final states and production mechanisms. As part of this thesis, the search for Higgs bosons produced in association with a top quark pair (t{bar t}H) has been performed. This channel is especially interesting for the understanding of the coupling between Higgs and the top quark. Even though the Standard Model Higgs boson is an attractive candidate, there is no reason to believe that the electroweak symmetry breaking is induced by only one Higgs field. In many models more than one Higgs boson are expected to exist, opening even more channels

  10. Measurement of top quark polarisation in t-channel single top quark production

    SciTech Connect

    Khachatryan, Vardan

    2015-11-09

    Our first measurement of the top quark spin asymmetry, sensitive to the top quark polarisation, in t-channel single top quark production is presented. It is based on a sample of pp collisions at a centre-of-mass energy of 8 TeV corresponding to an integrated luminosity of 19.7 fb-1. A high-purity sample of t-channel single top quark events with an isolated muon is selected. Signal and background components are estimated using a fit to data. Furthermore, a differential cross section measurement, corrected for detector effects, of an angular observable sensitive to the top quark polarisation is performed. The differential distribution is used to extract a top quark spin asymmetry of 0.26 ± 0.03 (stat) ± 0.10 (syst), which is compatible with a p-value of 4.6% with the standard model prediction of 0.44.

  11. Measurement of top quark polarisation in t-channel single top quark production

    NASA Astrophysics Data System (ADS)

    Khachatryan, V.; Sirunyan, A. M.; Tumasyan, A.; Adam, W.; Asilar, E.; Bergauer, T.; Brandstetter, J.; Brondolin, E.; Dragicevic, M.; Erö, J.; Flechl, M.; Friedl, M.; Frühwirth, R.; Ghete, V. M.; Hartl, C.; Hörmann, N.; Hrubec, J.; Jeitler, M.; Knünz, V.; König, A.; Krammer, M.; Krätschmer, I.; Liko, D.; Matsushita, T.; Mikulec, I.; Rabady, D.; Rahbaran, B.; Rohringer, H.; Schieck, J.; Schöfbeck, R.; Strauss, J.; Treberer-Treberspurg, W.; Waltenberger, W.; Wulz, C.-E.; Mossolov, V.; Shumeiko, N.; Suarez Gonzalez, J.; Alderweireldt, S.; Cornelis, T.; de Wolf, E. A.; Janssen, X.; Knutsson, A.; Lauwers, J.; Luyckx, S.; van de Klundert, M.; van Haevermaet, H.; van Mechelen, P.; van Remortel, N.; van Spilbeeck, A.; Abu Zeid, S.; Blekman, F.; D'Hondt, J.; Daci, N.; de Bruyn, I.; Deroover, K.; Heracleous, N.; Keaveney, J.; Lowette, S.; Moreels, L.; Olbrechts, A.; Python, Q.; Strom, D.; Tavernier, S.; van Doninck, W.; van Mulders, P.; van Onsem, G. P.; van Parijs, I.; Barria, P.; Brun, H.; Caillol, C.; Clerbaux, B.; de Lentdecker, G.; Fasanella, G.; Favart, L.; Grebenyuk, A.; Karapostoli, G.; Lenzi, T.; Léonard, A.; Maerschalk, T.; Marinov, A.; Perniè, L.; Randle-Conde, A.; Seva, T.; Vander Velde, C.; Vanlaer, P.; Yonamine, R.; Zenoni, F.; Zhang, F.; Beernaert, K.; Benucci, L.; Cimmino, A.; Crucy, S.; Dobur, D.; Fagot, A.; Garcia, G.; Gul, M.; McCartin, J.; Ocampo Rios, A. A.; Poyraz, D.; Ryckbosch, D.; Salva, S.; Sigamani, M.; Tytgat, M.; van Driessche, W.; Yazgan, E.; Zaganidis, N.; Basegmez, S.; Beluffi, C.; Bondu, O.; Brochet, S.; Bruno, G.; Caudron, A.; Ceard, L.; da Silveira, G. G.; Delaere, C.; Favart, D.; Forthomme, L.; Giammanco, A.; Hollar, J.; Jafari, A.; Jez, P.; Komm, M.; Lemaitre, V.; Mertens, A.; Musich, M.; Nuttens, C.; Perrini, L.; Pin, A.; Piotrzkowski, K.; Popov, A.; Quertenmont, L.; Selvaggi, M.; Vidal Marono, M.; Beliy, N.; Hammad, G. H.; Aldá Júnior, W. L.; Alves, F. L.; Alves, G. A.; Brito, L.; Correa Martins Junior, M.; Hamer, M.; Hensel, C.; Mora Herrera, C.; Moraes, A.; Pol, M. E.; Rebello Teles, P.; Belchior Batista Das Chagas, E.; Carvalho, W.; Chinellato, J.; Custódio, A.; da Costa, E. M.; de Jesus Damiao, D.; de Oliveira Martins, C.; Fonseca de Souza, S.; Huertas Guativa, L. M.; Malbouisson, H.; Matos Figueiredo, D.; Mundim, L.; Nogima, H.; Prado da Silva, W. L.; Santoro, A.; Sznajder, A.; Tonelli Manganote, E. J.; Vilela Pereira, A.; Ahuja, S.; Bernardes, C. A.; de Souza Santos, A.; Dogra, S.; Fernandez Perez Tomei, T. R.; Gregores, E. M.; Mercadante, P. G.; Moon, C. S.; Novaes, S. F.; Padula, Sandra S.; Romero Abad, D.; Ruiz Vargas, J. C.; Aleksandrov, A.; Hadjiiska, R.; Iaydjiev, P.; Rodozov, M.; Stoykova, S.; Sultanov, G.; Vutova, M.; Dimitrov, A.; Glushkov, I.; Litov, L.; Pavlov, B.; Petkov, P.; Ahmad, M.; Bian, J. G.; Chen, G. M.; Chen, H. S.; Chen, M.; Cheng, T.; Du, R.; Jiang, C. H.; Plestina, R.; Romeo, F.; Shaheen, S. M.; Spiezia, A.; Tao, J.; Wang, C.; Wang, Z.; Zhang, H.; Asawatangtrakuldee, C.; Ban, Y.; Li, Q.; Liu, S.; Mao, Y.; Qian, S. J.; Wang, D.; Xu, Z.; Avila, C.; Cabrera, A.; Chaparro Sierra, L. F.; Florez, C.; Gomez, J. P.; Gomez Moreno, B.; Sanabria, J. C.; Godinovic, N.; Lelas, D.; Puljak, I.; Ribeiro Cipriano, P. M.; Antunovic, Z.; Kovac, M.; Brigljevic, V.; Kadija, K.; Luetic, J.; Micanovic, S.; Sudic, L.; Attikis, A.; Mavromanolakis, G.; Mousa, J.; Nicolaou, C.; Ptochos, F.; Razis, P. A.; Rykaczewski, H.; Bodlak, M.; Finger, M.; Finger, M.; Abdelalim, A. A.; Awad, A.; El Sawy, M.; Mahrous, A.; Radi, A.; Calpas, B.; Kadastik, M.; Murumaa, M.; Raidal, M.; Tiko, A.; Veelken, C.; Eerola, P.; Pekkanen, J.; Voutilainen, M.; Härkönen, J.; Karimäki, V.; Kinnunen, R.; Lampén, T.; Lassila-Perini, K.; Lehti, S.; Lindén, T.; Luukka, P.; Mäenpää, T.; Peltola, T.; Tuominen, E.; Tuominiemi, J.; Tuovinen, E.; Wendland, L.; Talvitie, J.; Tuuva, T.; Besancon, M.; Couderc, F.; Dejardin, M.; Denegri, D.; Fabbro, B.; Faure, J. L.; Favaro, C.; Ferri, F.; Ganjour, S.; Givernaud, A.; Gras, P.; Hamel de Monchenault, G.; Jarry, P.; Locci, E.; Machet, M.; Malcles, J.; Rander, J.; Rosowsky, A.; Titov, M.; Zghiche, A.; Antropov, I.; Baffioni, S.; Beaudette, F.; Busson, P.; Cadamuro, L.; Chapon, E.; Charlot, C.; Dahms, T.; Davignon, O.; Filipovic, N.; Florent, A.; Granier de Cassagnac, R.; Jo, M.; Lisniak, S.; Mastrolorenzo, L.; Miné, P.; Naranjo, I. N.; Nguyen, M.; Ochando, C.; Ortona, G.; Paganini, P.; Pigard, P.; Regnard, S.; Salerno, R.; Sauvan, J. B.; Sirois, Y.; Strebler, T.; Yilmaz, Y.; Zabi, A.; Agram, J.-L.; Andrea, J.; Aubin, A.; Bloch, D.; Brom, J.-M.; Buttignol, M.; Chabert, E. C.; Chanon, N.; Collard, C.; Conte, E.; Coubez, X.; Fontaine, J.-C.; Gelé, D.; Goerlach, U.; Goetzmann, C.; Le Bihan, A.-C.; Merlin, J. A.; Skovpen, K.

    2016-04-01

    A first measurement of the top quark spin asymmetry, sensitive to the top quark polarisation, in t-channel single top quark production is presented. It is based on a sample of pp collisions at a centre-of-mass energy of 8 TeV corresponding to an integrated luminosity of 19.7 fb-1. A high-purity sample of t-channel single top quark events with an isolated muon is selected. Signal and background components are estimated using a fit to data. A differential cross section measurement, corrected for detector effects, of an angular observable sensitive to the top quark polarisation is performed. The differential distribution is used to extract a top quark spin asymmetry of 0.26 ± 0.03(stat) ± 0.10(syst), which is compatible with a p-value of 4.6% with the standard model prediction of 0.44. [Figure not available: see fulltext.

  12. Measurement of top quark polarisation in t-channel single top quark production

    DOE PAGESBeta

    Khachatryan, Vardan

    2016-04-13

    Our first measurement of the top quark spin asymmetry, sensitive to the top quark polarisation, in t-channel single top quark production is presented. It is based on a sample of pp collisions at a centre-of-mass energy of 8 TeV corresponding to an integrated luminosity of 19.7 fb-1. A high-purity sample of t-channel single top quark events with an isolated muon is selected. Signal and background components are estimated using a fit to data. Furthermore, a differential cross section measurement, corrected for detector effects, of an angular observable sensitive to the top quark polarisation is performed. The differential distribution is usedmore » to extract a top quark spin asymmetry of 0.26 ± 0.03 (stat) ± 0.10 (syst), which is compatible with a p-value of 4.6% with the standard model prediction of 0.44.« less

  13. Top Quark Properties in Little Higgs Models

    SciTech Connect

    Berger, C.F.; Perelstein, M.; Petriello, F.; /Wisconsin U., Madison

    2005-12-08

    Identifying the mechanism which breaks electroweak symmetry and generates fermion masses is one of the main physics goals for both the LHC and the ILC. Studies of the top quark have the potential to illuminate this issue; since it is the heaviest of the Standard Model (SM) fermions, the top is expected to couple strongly to the symmetry-breaking sector. Consequently, the structure of that sector can have significant, potentially observable effects on the properties of the top. for example, it is well known that the vector and axial t{bar t}Z form factors receive large corrections (of order 5-10%) in certain models of dynamical electroweak symmetry breaking [1]. At future colliders such as the LHC and the ILC, we will be able to pursue a program of precision top physics, similar to the program studying the Z at LEP and SLC. In this manuscript, they study the corrections to the top quark properties in ''Little Higgs'' models of electroweak symmetry breaking [2], and compare the expected deviations from the SM predictions with expected sensitivities of experiments at the LHC and the ILC. In the Little Higgs models, electroweak symmetry is driven by the radiative effects from the top sector, including the SM-like top and its heavy counterpart, a TeV-scale ''heavy top'' T. Probing this structure experimentally is quite difficult. While the LHC should be able to discover the T quark, its potential for studying its couplings is limited [3,4]. Direct production of the T will likely be beyond the kinematic reach of the ILC. However, we will show below that the corrections to the gauge couplings of the SM top, induced by its mixing with the T, will be observable at the ILC throughout the parameter range consistent with naturalness. Measuring these corrections will provide a unique window on the top sector of the Little Higgs. Many Little Higgs models have been proposed in the literature. We will consider two examples in this study, the ''Littlest Higgs'' model [5], and its

  14. Effects of High-Top and Low-Top Shoes on Ankle Inversion

    PubMed Central

    Ricard, Mark D.; Schulties, Shane S.; Saret, Jose J.

    2000-01-01

    Objective: To determine the differences in the rate and amount of ankle inversion in subjects wearing high-top and low-top shoes. Design and Setting: Subjects were filmed at 60 Hz while on an inversion platform that suddenly inverted the right ankle 35°. We measured 5 trials of sudden inversion for each subject in high-top and low-top shoes. Subjects: Twenty male subjects with no history of lower leg injury within the previous 6 months. Measurements: We measured ankle inversion using video motion analysis techniques at 60 Hz. A2 x 5 factorial repeated- measures analysis of variance was used to test for significant differences in the amount of inversion, average rate of inversion, and maximum rate of inversion. Results: The high-top shoes significantly reduced the amount and rate of inversion. The high-top shoes reduced the amount of inversion by 4.5°, the maximum rate of inversion by 100.1°/s, and the average rate of inversion by 73.0°/s. Conclusions: The high-top shoes were more effective in reducing the amount and rate of inversion than the low-top shoes. Depending upon the loading conditions, high-top shoes may help prevent some ankle sprains. ImagesFigure 1.Figure 2.Figure 3. PMID:16558606

  15. Production and decay of heavy top quarks

    SciTech Connect

    Kauffman, R.P.

    1989-08-01

    Experimental evidence indicates that the top quark exists and has a mass between 50 and 200 GeV/c{sup 2}. The decays of a top quark with a mass in this range are studied with emphasis placed on the mass region near the threshold for production of real W bosons. Topics discussed are: (1) possible enhancement of strange quark production when M{sub W} + m{sub s} < m{sub t} < M{sub W} + m{sub b}; (2) exclusive decays of T mesons to B and B{asterisk} mesons using the non-relativistic quark model; (3) polarization of intermediate W's in top quark decay as a source of information on the top quark mass. The production of heavy top quarks in an e{sup +}e{sup {minus}} collider with a center-of-mass energy of 2 TeV is studied. The effective-boson approximation for photons, Z{sup 0}'s and W's is reviewed and an analogous approximation for interfaces between photons and Z{sup 0}'s is developed. The cross sections for top quark pair production from photon-photon, photon-Z{sup 0}, Z{sup 0}Z{sup 0}, and W{sup +}W{sup {minus}} fusion are calculated using the effective-boson approximation. Production of top quarks along with anti-bottom quarks via {gamma}W{sup +} and Z{sup 0}W{sup +} fusion is studied. An exact calculation of {gamma}e{sup +} {yields} {bar {nu}}t{bar b} is made and compared with the effective-W approximation. 31 refs., 46 figs.

  16. Heavy flavor production and top quark search at hadron colliders

    SciTech Connect

    Baer, H.A.

    1991-01-01

    We review heavy flavor production at hadron colliders, with an eye towards the physics of the top quark. Motivation for existence of top, and current status of top search are reviewed. The physics of event simulation at hadron colliders is reviewed. We discuss characteristics of top quark events at p{bar p} colliders that may aid in distinguishing the top quark signal from Standard Model backgrounds, and illustrate various cuts which may be useful for top discovery. Top physics at hadron supercolliders is commented upon, as well as top quark mass measurement techniques. 22 refs., 5 figs.

  17. Physics of Stratocumulus Top (POST): turbulence characteristics

    NASA Astrophysics Data System (ADS)

    Jen-La Plante, Imai; Ma, Yongfeng; Nurowska, Katarzyna; Gerber, Hermann; Khelif, Djamal; Karpinska, Katarzyna; Kopec, Marta K.; Kumala, Wojciech; Malinowski, Szymon P.

    2016-08-01

    Turbulence observed during the Physics of Stratocumulus Top (POST) research campaign is analyzed. Using in-flight measurements of dynamic and thermodynamic variables at the interface between the stratocumulus cloud top and free troposphere, the cloud top region is classified into sublayers, and the thicknesses of these sublayers are estimated. The data are used to calculate turbulence characteristics, including the bulk Richardson number, mean-square velocity fluctuations, turbulence kinetic energy (TKE), TKE dissipation rate, and Corrsin, Ozmidov and Kolmogorov scales. A comparison of these properties among different sublayers indicates that the entrainment interfacial layer consists of two significantly different sublayers: the turbulent inversion sublayer (TISL) and the moist, yet hydrostatically stable, cloud top mixing sublayer (CTMSL). Both sublayers are marginally turbulent, i.e., the bulk Richardson number across the layers is critical. This means that turbulence is produced by shear and damped by buoyancy such that the sublayer thicknesses adapt to temperature and wind variations across them. Turbulence in both sublayers is anisotropic, with Corrsin and Ozmidov scales as small as ˜ 0.3 and ˜ 3 m in the TISL and CTMSL, respectively. These values are ˜ 60 and ˜ 15 times smaller than typical layer depths, indicating flattened large eddies and suggesting no direct mixing of cloud top and free-tropospheric air. Also, small scales of turbulence are different in sublayers as indicated by the corresponding values of Kolmogorov scales and buoyant and shear Reynolds numbers.

  18. Top-down causation and social structures

    PubMed Central

    Elder-Vass, Dave

    2012-01-01

    Top-down causation has been implicit in many sociological accounts of social structure and its influence on social events, but the social sciences have struggled to provide a coherent account of top-down causation itself. This paper summarizes a critical realist view of causation and emergence, shows how it supports a plausible account of top-down causation and then applies this account to the social world. The argument is illustrated by an examination of the concept of a norm circle, a kind of social entity that, it is argued, is causally responsible for the influence of normative social institutions. Nevertheless, social entities are structured rather differently from ordinary material ones, with the result that the compositional level structure of reality implicit in the concept of top-down causation has some limitations in the social world. The paper closes by considering what might be involved in examining how top-down causation can be shown to be at work in the social domain. PMID:23386963

  19. Towards the Top with D0

    SciTech Connect

    Deliot, Frederic

    2012-01-01

    The plan of this manuscript follows my research path over the past 10 years: the muon identification and common analysis tools at DØ, the measurement of the inclusive production of W boson decaying into muon and top quark studies. In the first section, I describe my work about muon identification, certification of the standard muon identification criteria, measurement of the muon selection efficiency and about the development of common analysis format and tools. In the second section, I explain how these efficiency measurements can be used to measure the inclusive W boson production cross section in the muon channel. The W ! μν cross section measurement can be seen as a standard candle to establish several analysis pieces that have to be put in place to perform more complex measurements like top quark analyses. In the last section I introduce more extensively the top quark physics at the Tevatron and describe in more details the main analyses in the dilepton channel I was involved in: the measurement of the tt inclusive cross section in the dilepton channel as well as the ratio of cross sections, the measurement of the top quark mass in the dilepton channel, the extraction of the mass from the tt cross section and the Tevatron top quark mass combination. Before concluding, I finish the section with the description of the latest results on the tt charge asymmetry both at the Tevatron and at the LHC.

  20. Top Stars: An Opportunity for Educators

    NASA Astrophysics Data System (ADS)

    Kinnison, S. M. P.

    2010-08-01

    Think you're a Top Star? Want to find out what it takes? Learn about NASA's Top Stars contest and how you can participate. Throughout its lifetime, the Hubble Space Telescope has inspired and promoted education. The final Hubble servicing mission in May of this year and the celebration of Hubble's 20th anniversary in 2010 are key mission milestones, and both enrich activities for the 2009 International Year of Astronomy. U.S. formal (K-12 and college) and informal educators are invited to submit their best examples of using NASA's Hubble Space Telescope for science, technology, engineering or mathematics education. Those selected as Top Stars will receive national recognition and awards. Participants will learn about the contest, the recognition and awards, and how to register and save their entries on the Top Stars Web site. Educators are allowed and encouraged to revise, improve and re-submit their entries up to the final deadline of January 2, 2010. The contest is open to individuals and teams of up to four people who are U.S. citizens and are at least 21 years old. NASA and Institute for Global Environmental Strategies (IGES) employees or their contractors are not eligible. IGES is conducting Top Stars with NASA funding and in cooperation with the Space Telescope Science Institute.

  1. Portable top drive cuts horizontal drilling costs

    SciTech Connect

    Jackson, B.; Yager, D.

    1993-11-01

    Economic analysis of a seven-well, long-reach horizontal drilling program into an unconsolidated, heavy-oil-bearing reservoir in Winter field near the Alberta/Saskatchewan border in Canada reveals that -- in the right application -- renting a portable top drive drilling system can reduce total drilling costs. Use of the portable top drive combined with other cost-saving measures enabled Saskoil, one of Canada`s larger independents, to drill more cheaply, on a cost-per-meter basis, in 1993 than in 1992. This was despite significant rental rates for drilling rigs and directional drilling services caused by increased demand in Western Canada. Total cost savings of 10% on wells that would otherwise cost in the (C) $500,000 range are believed realistic. Based on this year`s performance, Saskoil recommends top drive for the company`s future horizontal wells in this area. This article describes the operator`s horizontal well program, advantages of top drive in that program and how it was installed and applied. Estimated time savings for six wells, plus other ways top drive can cut costs and improve operations are discussed.

  2. Adiabatic Field-Free Alignment of Asymmetric Top Molecules with an Optical Centrifuge

    NASA Astrophysics Data System (ADS)

    Korobenko, A.; Milner, V.

    2016-05-01

    We use an optical centrifuge to align asymmetric top SO2 molecules by adiabatically spinning their most polarizable O-O axis. The effective centrifugal potential in the rotating frame confines the sulfur atoms to the plane of the laser-induced rotation, leading to the planar molecular alignment that persists after the molecules are released from the centrifuge. The periodic appearance of the full three-dimensional alignment, typically observed only with linear and symmetric top molecules, is also detected. Together with strong in-plane centrifugal forces, which bend the molecules by up to 10 deg, permanent field-free alignment offers new ways of controlling molecules with laser light.

  3. Top differential cross section measurements (Tevatron)

    SciTech Connect

    Jung, Andreas W.

    2012-01-01

    Differential cross sections in the top quark sector measured at the Fermilab Tevatron collider are presented. CDF used 2.7 fb{sup -1} of data and measured the differential cross section as a function of the invariant mass of the t{bar t} system. The measurement shows good agreement with the standard model and furthermore is used to derive limits on the ratio {kappa}/M{sub Pl} for gravitons which decay to top quarks in the Randall-Sundrum model. D0 used 1.0 fb{sup -1} of data to measure the differential cross section as a function of the transverse momentum of the top-quark. The measurement shows a good agreement to the next-to-leading order perturbative QCD prediction and various other standard model predictions.

  4. Experimental Study of Top Heat Mode Thermosyphon

    NASA Astrophysics Data System (ADS)

    Hirashima, Masao; Kimura, Kenichiro; Utsumi, Yoichi; Kimura, Kenichi; Negishi, Kanji

    The purpose of this study is to develop the top heat mode thermosyphon that is very attractive means, for example, to accumulate directly the summer solar energy into the underground soil for the winter season. In this case, it can exclude the complex piping and mechanical pump to circulate the hot water absorbed the solar energy through the piping system buried in the soil layer. The several ideas concerning the top heat thermosyphon had been proposed, however, there were few reports on the definite experiments. The authors have carried out the experimental study of the top heat mode thermosyphon, with a simple lifting pipe, which could draw the working liquid from the under condenser to the upper evaporator section. The improvement of the main construction parts such as evaporator, lifting pipe, liquid reservoir trap and vapour nozzle have been performed in the present experiment in order to obtain the optimum operation range.

  5. Top-down vortices developed in a cylindrical annulus cooled on the top

    NASA Astrophysics Data System (ADS)

    Navarro, M. C.; Herrero, H.

    2013-07-01

    In this paper we study the generation of top-down vortices by thermoconvective mechanisms in a cylindrical annulus nonhomogeneously cooled on the top. Assuming axisymmetry we study the structure of the vortices, characterized by a spiral downward motion, similar to that observed in tornadoes generated in supercell storms.

  6. An Efficiency Comparison of MBA Programs: Top 10 versus Non-Top 10

    ERIC Educational Resources Information Center

    Hsu, Maxwell K.; James, Marcia L.; Chao, Gary H.

    2009-01-01

    The authors compared the cohort group of the top-10 MBA programs in the United States with their lower-ranking counterparts on their value-added efficiency. The findings reveal that the top-10 MBA programs in the United States are associated with statistically higher average "technical and scale efficiency" and "scale efficiency", but not with a…

  7. Top2 and Sgs1-Top3 Act Redundantly to Ensure rDNA Replication Termination

    PubMed Central

    Fredsøe, Jacob; Nielsen, Ida; Pedersen, Jakob Madsen; Bentsen, Iben Bach; Lisby, Michael; Bjergbaek, Lotte; Andersen, Anni H

    2015-01-01

    Faithful DNA replication with correct termination is essential for genome stability and transmission of genetic information. Here we have investigated the potential roles of Topoisomerase II (Top2) and the RecQ helicase Sgs1 during late stages of replication. We find that cells lacking Top2 and Sgs1 (or Top3) display two different characteristics during late S/G2 phase, checkpoint activation and accumulation of asymmetric X-structures, which are both independent of homologous recombination. Our data demonstrate that checkpoint activation is caused by a DNA structure formed at the strongest rDNA replication fork barrier (RFB) during replication termination, and consistently, checkpoint activation is dependent on the RFB binding protein, Fob1. In contrast, asymmetric X-structures are formed independent of Fob1 at less strong rDNA replication fork barriers. However, both checkpoint activation and formation of asymmetric X-structures are sensitive to conditions, which facilitate fork merging and progression of replication forks through replication fork barriers. Our data are consistent with a redundant role of Top2 and Sgs1 together with Top3 (Sgs1-Top3) in replication fork merging at rDNA barriers. At RFB either Top2 or Sgs1-Top3 is essential to prevent formation of a checkpoint activating DNA structure during termination, but at less strong rDNA barriers absence of the enzymes merely delays replication fork merging, causing an accumulation of asymmetric termination structures, which are solved over time. PMID:26630413

  8. Top-down vortices developed in a cylindrical annulus cooled on the top.

    PubMed

    Navarro, M C; Herrero, H

    2013-07-01

    In this paper we study the generation of top-down vortices by thermoconvective mechanisms in a cylindrical annulus nonhomogeneously cooled on the top. Assuming axisymmetry we study the structure of the vortices, characterized by a spiral downward motion, similar to that observed in tornadoes generated in supercell storms. PMID:23944599

  9. A measurement of the top quark's charge

    SciTech Connect

    Unalan, Zeynep Gunay; /Michigan State U.

    2007-11-01

    The top quark was discovered in 1995 at the Fermilab National Accelerator Laboratory (Fermilab). One way to confirm if the observed top quark is really the top quark posited in the Standard Model (SM) is to measure its electric charge. In the Standard Model the top quark is the isospin partner of the bottom quark and is expected to have a charge of +2/3. However, an alternative 'exotic' model has been proposed with a fourth generation exotic quark that has the same characteristics, such as mass, as our observed top but with a charge of -4/3. This thesis presents the first CDF measurement of the top quark's charge via its decay products, a W boson and a bottom quark, using {approx} 1 fb{sup -1} of data. The data were collected by the CDF detector from proton anti-proton (p{bar p}) collisions at {radical}s = 1.96 TeV at Fermilab. We classify events depending on the charges of the bottom quark and associated W boson and count the number of events which appear 'SM-like' or 'exotic-like' with a SM-like event decaying as t {yields} W{sup +}b and an exotic event as t {yields} W{sup -}b. We find the p-value under the Standard Model hypothesis to be 0:35 which is consistent with the Standard Model. We exclude the exotic quark hypothesis at an 81% confidence level, for which we have chosen a priori that the probability of incorrectly rejecting the SM would be 1%. The calculated Bayes Factor (BF) is 2 x Ln(BF)=8.54 which is interpreted as the data strongly favors the Standard Model over the exotic quark hypothesis.

  10. Evidence for production of single top quarks

    SciTech Connect

    Abazov, V. M.; Alexeev, G. D.; Kalinin, A. M.; Kharzheev, Y. M.; Malyshev, V. L.; Tokmenin, V. V.; Vertogradov, L. S.; Yatsunenko, Y. A.; Abbott, B.; Gutierrez, P.; Hossain, S.; Jain, S.; Rominsky, M.; Severini, H.; Skubic, P.; Strauss, M.; Abolins, M.; Benitez, J. A.; Brock, R.; Dyer, J.

    2008-07-01

    We present first evidence for the production of single top quarks in the D0 detector at the Fermilab Tevatron pp collider. The standard model predicts that the electroweak interaction can produce a top quark together with an antibottom quark or light quark, without the antiparticle top-quark partner that is always produced from strong-coupling processes. Top quarks were first observed in pair production in 1995, and since then, single top-quark production has been searched for in ever larger data sets. In this analysis, we select events from a 0.9 fb{sup -1} data set that have an electron or muon and missing transverse energy from the decay of a W boson from the top-quark decay, and two, three, or four jets, with one or two of the jets identified as originating from a b hadron decay. The selected events are mostly backgrounds such as W+jets and tt events, which we separate from the expected signals using three multivariate analysis techniques: boosted decision trees, Bayesian neural networks, and matrix-element calculations. A binned likelihood fit of the signal cross section plus background to the data from the combination of the results from the three analysis methods gives a cross section for single top-quark production of {sigma}(pp{yields}tb+X,tqb+X)=4.7{+-}1.3 pb. The probability to measure a cross section at this value or higher in the absence of signal is 0.014%, corresponding to a 3.6 standard deviation significance. The measured cross section value is compatible at the 10% level with the standard model prediction for electroweak top-quark production. We use the cross section measurement to directly determine the Cabibbo-Kobayashi-Maskawa quark mixing matrix element that describes the Wtb coupling and find |V{sub tb}f{sub 1}{sup L}|=1.31{sub -0.21}{sup +0.25}, where f{sub 1}{sup L} is a generic vector coupling. This model-independent measurement translates into 0.68<|V{sub tb}|{<=}1 at the 95% C.L. in the standard model.

  11. Evidence for production of single top quarks

    SciTech Connect

    Abazov, V.M.; Abbott, B.; Abolins, M.; Acharya, B.S.; Adams, M.; Adams, T.; Aguilo, E.; Ahn, S.H.; Ahsan, M.; Alexeev, G.D.; Alkhazov, G.; /St. Petersburg, INP /Michigan U.

    2008-03-01

    We present first evidence for the production of single top quarks in the D0 detector at the Fermilab Tevatron p{bar p} collider. The standard model predicts that the electroweak interaction can produce a top quark together with an antibottom quark or light quark, without the antiparticle top quark partner that is always produced from strong coupling processes. Top quarks were first observed in pair production in 1995, and since then, single top quark production has been searched for in ever larger datasets. In this analysis, we select events from a 0.9 fb{sup -1} dataset that have an electron or muon and missing transverse energy from the decay of a W boson from the top quark decay, and two, three, or four jets, with one or two of the jets identified as originating from a b hadron decay. The selected events are mostly backgrounds such as W+jets and t{bar t} events, which we separate from the expected signals using three multivariate analysis techniques: boosted decision trees, Bayesian neural networks, and matrix element calculations. A binned likelihood fit of the signal cross section plus background to the data from the combination of the results from the three analysis methods gives a cross section for single top quark production of {sigma}(p{bar p} {yields} tb + X, tqb + X) = 4.7 {+-} 1.3 pb. The probability to measure a cross section at this value or higher in the absence of signal is 0.014%, corresponding to a 3.6 standard deviation significance. The measured cross section value is compatible at the 10% level with the standard model prediction for electroweak top quark production. We use the cross section measurement to directly determine the Cabibbo-Kobayashi-Maskawa quark mixing matrix element that describes the Wtb coupling and find |V{sub tb}f{sub 1}{sup L}| = 1.31{sub -0.21}{sup +0.25}, where f{sub 1}{sup L} is a generic vector coupling. This model-independent measurement translates into 0.68 < |V{sub tb}| {le} 1 at the 95% C.L. in the standard model.

  12. TOP500 Supercomputers for November 2003

    SciTech Connect

    Strohmaier, Erich; Meuer, Hans W.; Dongarra, Jack; Simon, Horst D.

    2003-11-16

    22nd Edition of TOP500 List of World s Fastest Supercomputers Released MANNHEIM, Germany; KNOXVILLE, Tenn.; BERKELEY, Calif. In what has become a much-anticipated event in the world of high-performance computing, the 22nd edition of the TOP500 list of the worlds fastest supercomputers was released today (November 16, 2003). The Earth Simulator supercomputer retains the number one position with its Linpack benchmark performance of 35.86 Tflop/s (''teraflops'' or trillions of calculations per second). It was built by NEC and installed last year at the Earth Simulator Center in Yokohama, Japan.

  13. Thermionic Energy Conversion (TEC) topping thermoelectrics

    NASA Technical Reports Server (NTRS)

    Morris, J. F.

    1981-01-01

    Performance expectations for thermionic and thermoelectric energy conversion systems are reviewed. It is noted that internal radiation effects diminish thermoelectric figures of merit significantly at 1000 K and substantially at 2000 K; the effective thermal conductivity contribution of intrathermoelectric radiative dissipation increases with the third power of temperature. It is argued that a consideration of thermoelectric power generation with high temperature heat sources should include utilization of thermionic energy conversion (TEC) topping thermoelectrics. However TEC alone or TEC topping more efficient conversion systems like steam or gas turbines, combined cycles, or Stirling engines would be more desirable generally.

  14. Top Quark Spin Correlations at the Tevatron

    SciTech Connect

    Head, Tim; /Manchester U.

    2010-07-01

    Recent measurements of the correlation between the spin of the top and the spin of the anti-top quark produced in proton anti-proton scattering at a center of mass energy of {radical}s = 1.96 Tev by the CDF and D0 collaborations are discussed. using up to 4.3 fb{sup -1} of data taken with the CDF and D0 detectors the spin correlation parameter C, the degree to which the spins are correlated, is measured in dileptonic and semileptonic final states. The measurements are found to be in agreement with Standard Model predictions.

  15. Total on-line purchasing system (TOPS)

    SciTech Connect

    Collins, N.

    1995-11-01

    The Information Management Division (IMD) at LLNL is developing a new purchasing system for the Procurement Department. The first major development of this new system is called, {open_quotes}Total On-Line Purchasing System{close_quotes} (TOPS). TOPS will help speed up the requisitioning process by having requisitions electronically entered by requesters and electronically sent to buyers to be put on Purchase Orders. The new purchasing system will use Electronic Commerce (EC)/Electronic Data Interchange (EDI), to help increase transaction flows for shipping notices, RFQs, Quotes, Purchase Orders, and Invoices. ANSI X.12 is the EDI standard that this new EC will use.

  16. Measurement of the Top Quark Mass

    SciTech Connect

    Blair, R.E.; Byrum, K.L.; Kovacs, E.; Kuhlmann, S.E.; LeCompte, T.; Nodulman, L.; Breccia, L.; Brunetti, R.; Deninno, M.; Fiori, I.; Mazzanti, P.; Behrends, S.; Bensinger, J.; Blocker, C.; Kirsch, L.; Lamoureux, J.I.; Bonushkin, Y.; Hauser, J.; Lindgren, M.; Amadon, A.; Berryhill, J.; Contreras, M.; Culbertson, R.; Frisch, H.; Grosso-Pilcher, C.; Hohlmann, M.; Cronin-Hennessy, D.; Dittmann, J.R.; Goshaw, A.T.; Khazins, D.; Kowald, W.; Oh, S.H.; Albrow, M.G.; Atac, M.; Beretvas, A.; Berge, J.P.; Biery, K.; Binkley, M.; Buckley-Geer, E.; Byon-Wagner, A.; Chlebana, F.; Cihangir, S.; Cooper, J.; DeJongh, F.; Demina, R.; Derwent, P.F.; Elias, J.E.; Erdmann, W.; Flaugher, B.; Foster, G.W.; Freeman, J.; Geer, S.; Hahn, S.R.; Harris, R.M.; Incandela, J.; Jensen, H.; Joshi, U.; Kennedy, R.D.; Kephart, R.; Lammel, S.; Lewis, J.D.; Limon, P.; Lukens, P.; Maeshima, K.; Marriner, J.P.; Miao, T.; Mukherjee, A.; Nelson, C.; Newman-Holmes, C.; Patrick, J.; Klimenko, S.; Konigsberg, J.; Korytov, A.; Nomerotski, A.; Barone, M.; Bertolucci, S.; Cordelli, M.; DellAgnello, S.; Giromini, P.; Happacher, F.; Miscetti, S.; Parri, A.; Clark, A.G.; Couyoumtzelis, C.; Kambara, H.; Baumann, T.; Franklin, M.; Gordon, A.; Hamilton, R.; Huth, J.; and others

    1998-03-01

    We present a measurement of the top quark mass using a sample of t{bar t} decays into an electron or a muon, a neutrino, and four jets. The data were collected in p{bar p} collisions at {radical}(s)=1.8 TeV with the Collider Detector at Fermilab and correspond to an integrated luminosity of 109 pb{sup {minus}1} . We measure the top quark mass to be 175.9{plus_minus}4.8(stat){plus_minus}4.9( syst) GeV /c{sup 2} . {copyright} {ital 1998} {ital The American Physical Society}

  17. Observation of Single Top Quark Production

    SciTech Connect

    Heinson, Ann; Junk, Tom R.; /Fermilab

    2011-01-01

    The field of experimental particle physics has become more sophisticated over time, as fewer, larger experimental collaborations search for small signals in samples with large components of background. The search for and the observation of electroweak single top quark production by the CDF and D0 collaborations at Fermilab's Tevatron collider are an example of an elaborate effort to measure the rate of a very rare process in the presence of large backgrounds and to learn about the properties of the top quark's weak interaction. We present here the techniques used to make this groundbreaking measurement and the interpretation of the results in the context of the Standard Model.

  18. New Multigrid Solver Advances in TOPS

    SciTech Connect

    Falgout, R D; Brannick, J; Brezina, M; Manteuffel, T; McCormick, S

    2005-06-27

    In this paper, we highlight new multigrid solver advances in the Terascale Optimal PDE Simulations (TOPS) project in the Scientific Discovery Through Advanced Computing (SciDAC) program. We discuss two new algebraic multigrid (AMG) developments in TOPS: the adaptive smoothed aggregation method ({alpha}SA) and a coarse-grid selection algorithm based on compatible relaxation (CR). The {alpha}SA method is showing promising results in initial studies for Quantum Chromodynamics (QCD) applications. The CR method has the potential to greatly improve the applicability of AMG.

  19. Top quark property measurements with ATLAS

    NASA Astrophysics Data System (ADS)

    Rudolph, M.; Atlas Collaboration

    2016-07-01

    This contribution covers recent results on the properties of the top quark as measured with the ATLAS detector at the Large Hadron Collider, using data collected at center-of-mass energies of 7 and 8TeV during 2011 and 2012. Results on the t bar{{t}} charge asymmetry and spin correlation, and on the mass of the top quark are discussed. The most recent results expand on the first ATLAS measurements with complementary analysis channels, new observables, and direct comparisons to new physics models. No significant deviations from Standard Model predictions have been found.

  20. Top and Electroweak Measurements at the Tevatron

    SciTech Connect

    Bartos, P.

    2016-01-01

    In this report, we summarize the latest results of the top-quark mass and electroweak measurements from the Tevatron. Since the world combination of top-quark mass measurements was done, CDF and D0 experiments improved the precision of several results. Some of them reach the relative precition below 1% for a single measurement. From the electroweak results, we report on the WW and WZ production cross section, measurements of the weak mixing angle and indirect measurements of W boson mass. The Tevatron results of the weak mixing angle are still the most precise ones of hadron colliders.

  1. Studies of top quark properties and search for electroweak single top quark production at the Tevatron

    SciTech Connect

    Datta, Mousumi; /Fermilab

    2007-10-01

    The top quark was discovered in 1995 by the CDF and D0 experiments at the Fermilab Tevatron during the Run I operation. Since the start of the Tevatron Run II in 2001, both experiments have collected {approx}2 fb{sup -1} data samples, which are over twenty times larger than that used in the Run 1 discovery. This larger data sample allows more precise studies of top-quark properties; differences between observed top-quark properties and the Standard Model (SM) prediction may give hints to possible physics beyond the SM. Here we present the latest results on the measurements of top-quark properties and the search for electroweak (EW) single top quark production from the CDF and D0 collaborations. The integrated luminosity used for the measurements corresponds to about 1 fb{sup -1}.

  2. Designer nanoscale DNA assemblies programmed from the top down.

    PubMed

    Veneziano, Rémi; Ratanalert, Sakul; Zhang, Kaiming; Zhang, Fei; Yan, Hao; Chiu, Wah; Bathe, Mark

    2016-06-24

    Scaffolded DNA origami is a versatile means of synthesizing complex molecular architectures. However, the approach is limited by the need to forward-design specific Watson-Crick base pairing manually for any given target structure. Here, we report a general, top-down strategy to design nearly arbitrary DNA architectures autonomously based only on target shape. Objects are represented as closed surfaces rendered as polyhedral networks of parallel DNA duplexes, which enables complete DNA scaffold routing with a spanning tree algorithm. The asymmetric polymerase chain reaction is applied to produce stable, monodisperse assemblies with custom scaffold length and sequence that are verified structurally in three dimensions to be high fidelity by single-particle cryo-electron microscopy. Their long-term stability in serum and low-salt buffer confirms their utility for biological as well as nonbiological applications. PMID:27229143

  3. Designer nanoscale DNA assemblies programmed from the top down

    NASA Astrophysics Data System (ADS)

    Veneziano, Rémi; Ratanalert, Sakul; Zhang, Kaiming; Zhang, Fei; Yan, Hao; Chiu, Wah; Bathe, Mark

    2016-06-01

    Scaffolded DNA origami is a versatile means of synthesizing complex molecular architectures. However, the approach is limited by the need to forward-design specific Watson-Crick base pairing manually for any given target structure. Here, we report a general, top-down strategy to design nearly arbitrary DNA architectures autonomously based only on target shape. Objects are represented as closed surfaces rendered as polyhedral networks of parallel DNA duplexes, which enables complete DNA scaffold routing with a spanning tree algorithm. The asymmetric polymerase chain reaction is applied to produce stable, monodisperse assemblies with custom scaffold length and sequence that are verified structurally in three dimensions to be high fidelity by single-particle cryo-electron microscopy. Their long-term stability in serum and low-salt buffer confirms their utility for biological as well as nonbiological applications.

  4. Alligator clips to molecular dimensions

    NASA Astrophysics Data System (ADS)

    Prokopuk, Nicholas; Son, Kyung-Ah

    2008-09-01

    Techniques for fabricating nanospaced electrodes suitable for studying electron tunneling through metal-molecule-metal junctions are described. In one approach, top contacts are deposited/placed on a self-assembled monolayer or Langmuir-Blodgett film resting on a conducting substrate, the bottom contact. The molecular component serves as a permanent spacer that controls and limits the electrode separations. The top contact can be a thermally deposited metal film, liquid mercury drop, scanning probe tip, metallic wire or particle. Introduction of the top contact can greatly affect the electrical conductance of the intervening molecular film by chemical reaction, exerting pressure, or simply migrating through the organic layer. Alternatively, vacant nanogaps can be fabricated and the molecular component subsequently inserted. Strategies for constructing vacant nanogaps include mechanical break junction, electromigration, shadow mask lithography, focused ion beam deposition, chemical and electrochemical plating techniques, electron-beam lithography, and molecular and atomic rulers. The size of the nanogaps must be small enough to allow the molecule to connect both leads and large enough to keep the molecules in a relaxed and undistorted state. A significant advantage of using vacant nanogaps in the construction of metal-molecule-metal devices is that the junction can be characterized with and without the molecule in place. Any electrical artifacts introduced by the electrode fabrication process are more easily deconvoluted from the intrinsic properties of the molecule.

  5. 14. TIP TOP MINE. TAILINGS LOCATED DIRECTLY WEST FROM TIP ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. TIP TOP MINE. TAILINGS LOCATED DIRECTLY WEST FROM TIP TOP HOUSE. ID-31-C-12 WOODEN STRUCTURE IS VISIBLE IN TOP LEFT. CABLES VISIBLE LEFT AND CENTER OF TAILINGS. HOUSE IS JUST OVER APEX OF TAILINGS. CAMERA POINTED EAST. - Florida Mountain Mining Sites, Tip Top Mine, West face Florida Mountain, approximately 150 feet below summit, Silver City, Owyhee County, ID

  6. 49 CFR 178.1050 - Top lift test.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Top lift test. 178.1050 Section 178.1050... Containers § 178.1050 Top lift test. (a) General. The top lift test must be conducted for the qualification of all of Flexible Bulk Containers design types to be lifted from the top. (b) Special...

  7. 49 CFR 178.812 - Top lift test.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false Top lift test. 178.812 Section 178.812... Top lift test. (a) General. The top lift test must be conducted for the qualification of all IBC design types designed to be lifted from the top or, for flexible IBCs, from the side. (b)...

  8. 49 CFR 178.812 - Top lift test.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Top lift test. 178.812 Section 178.812... Top lift test. (a) General. The top lift test must be conducted for the qualification of all IBC design types designed to be lifted from the top or, for flexible IBCs, from the side. (b)...

  9. 49 CFR 178.975 - Top lift test.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Top lift test. 178.975 Section 178.975... Packagings § 178.975 Top lift test. (a) General. The top lift test must be conducted for the qualification of all of Large Packagings design types to be lifted from the top or, for flexible Large Packagings,...

  10. 49 CFR 178.1050 - Top lift test.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false Top lift test. 178.1050 Section 178.1050... Containers § 178.1050 Top lift test. (a) General. The top lift test must be conducted for the qualification of all of Flexible Bulk Containers design types to be lifted from the top. (b) Special...

  11. 5 CFR 1312.27 - Top secret control.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 3 2012-01-01 2012-01-01 false Top secret control. 1312.27 Section 1312... Classified Information § 1312.27 Top secret control. The EOP Security Officer serves as the Top Secret... Top Secret material. The ATSCOs will be responsible for the accountability and custodianship of...

  12. 49 CFR 178.975 - Top lift test.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false Top lift test. 178.975 Section 178.975... Packagings § 178.975 Top lift test. (a) General. The top lift test must be conducted for the qualification of all of Large Packagings design types to be lifted from the top or, for flexible Large Packagings,...

  13. 5 CFR 1312.27 - Top secret control.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 3 2013-01-01 2013-01-01 false Top secret control. 1312.27 Section 1312... Classified Information § 1312.27 Top secret control. The EOP Security Officer serves as the Top Secret... Top Secret material. The ATSCOs will be responsible for the accountability and custodianship of...

  14. 49 CFR 178.812 - Top lift test.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Top lift test. 178.812 Section 178.812... Top lift test. (a) General. The top lift test must be conducted for the qualification of all IBC design types designed to be lifted from the top or, for flexible IBCs, from the side. (b)...

  15. 49 CFR 178.975 - Top lift test.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Top lift test. 178.975 Section 178.975... Packagings § 178.975 Top lift test. (a) General. The top lift test must be conducted for the qualification of all of Large Packagings design types to be lifted from the top or, for flexible Large Packagings,...

  16. 49 CFR 178.812 - Top lift test.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Top lift test. 178.812 Section 178.812... Top lift test. (a) General. The top lift test must be conducted for the qualification of all IBC design types designed to be lifted from the top or, for flexible IBCs, from the side. (b)...

  17. 5 CFR 1312.27 - Top secret control.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Top secret control. 1312.27 Section 1312... Classified Information § 1312.27 Top secret control. The EOP Security Officer serves as the Top Secret... Top Secret material. The ATSCOs will be responsible for the accountability and custodianship of...

  18. 5 CFR 1312.27 - Top secret control.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 3 2011-01-01 2011-01-01 false Top secret control. 1312.27 Section 1312... Classified Information § 1312.27 Top secret control. The EOP Security Officer serves as the Top Secret... Top Secret material. The ATSCOs will be responsible for the accountability and custodianship of...

  19. 49 CFR 178.812 - Top lift test.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Top lift test. 178.812 Section 178.812... Testing of IBCs § 178.812 Top lift test. (a) General. The top lift test must be conducted for the qualification of all IBC design types designed to be lifted from the top or, for flexible IBCs, from the...

  20. 49 CFR 178.975 - Top lift test.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Top lift test. 178.975 Section 178.975... Packagings § 178.975 Top lift test. (a) General. The top lift test must be conducted for the qualification of all of Large Packagings design types to be lifted from the top or, for flexible Large Packagings,...

  1. 5 CFR 1312.27 - Top secret control.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 3 2014-01-01 2014-01-01 false Top secret control. 1312.27 Section 1312... Classified Information § 1312.27 Top secret control. The EOP Security Officer serves as the Top Secret... Top Secret material. The ATSCOs will be responsible for the accountability and custodianship of...

  2. Top-up operation experience at APS.

    SciTech Connect

    Emery, L.

    1999-03-31

    The Advanced Photon Source (APS) is a 7-OeV, third-generation synchrotrons radiation source. To provide more stable beam for users, in September 1998 we began commissioning a new operating mode called ''top-up.'' In this mode, the beam current does not decay but is maintained at a high level using frequent injection, while photon shutters are open and photon beams are delivered to users. The hardware, software, and safety requirements for top-up will be reported. Safety issues related to injection with open photon shutters are covered in companion papers in this conference. Recent operational experience includes testing aspects of top-up injection and delivering beam to X-ray users for a few hours with fractional current stability of 10{sup {minus}3}. We expect to run several top-up operation shifts in Spring 1999. Issues of importance are orbit and emittance transients during the injection and scheduling of injection pulses for the convenience of users.

  3. Race to Top Districts "Personalize" Plans

    ERIC Educational Resources Information Center

    McNeil, Michele

    2013-01-01

    The 16 Race to the Top district winners, pushed by $400 million in federal grants that put a premium on personalized learning, are embarking on vastly different makeovers of the classroom experience--from districtwide approaches to a narrower blueprint focused on middle school math. Despite the divergent approaches, a review of the winning…

  4. VEHICLE ASSEMBLY BUILDING [VAB] & TOPPING OFF CEREMONIES

    NASA Technical Reports Server (NTRS)

    1965-01-01

    Dr. Kurt H. Debus, KSC's first director, adds his name to the thousands of signatures affixed to the 38-foot-long, four-ton steel beam used in the Vehicle Assembly Building ''topping off'' ceremonies held on April 14, 1965.

  5. Hurdles Ahead in "Race to Top"

    ERIC Educational Resources Information Center

    McNeil, Michele

    2009-01-01

    As states scramble to spend and report on millions of dollars of education stimulus funds already flowing their way, they face another daunting task if they want a shot at even more money: navigating the complex application process for $4 billion from the Race to the Top Fund. Merely filling out the award application will take each state 642…

  6. Multipurpose top for liquid helium Dewar

    NASA Technical Reports Server (NTRS)

    Murphy, R. S.; Anderholm, J. R.

    1972-01-01

    Multipurpose top was fabricated for liquid helium Dewar flask which guards against flash vaporization of liquid helium and allows boiling temperature of liquid helium to be lowered by reduction of ambient pressure in Dewar flask. Device is rugged and simple, and does not require frequent calibrations or adjustments.

  7. Induced Resistance to Beet Curly Top Virus

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Curly top management in many parts of the West has focused on the large-scale application of insecticides to beet leafhopper over-wintering grounds (perennial weeds) to control the leafhopper vector, often combined with host resistance. Insecticide application to rangeland has been challenged by env...

  8. Top Four Trends in Student Information Systems

    ERIC Educational Resources Information Center

    Weathers, Robert

    2013-01-01

    The modern student information systems (SIS) is a powerful administrative tool with robust functionality. As such, it is essential that school and district administrators consider the top trends in modern student information systems before going forward with system upgrades or new purchases. These trends, described herein, are: (1) Support for…

  9. Evaluation of a Bench Top Mechanical Delinter

    Technology Transfer Automated Retrieval System (TEKTRAN)

    This presentation will report on current research associated with a new mechancial delinter being developed at the Cotton Production and Processing Research Unit in conjunction with Cotton Inc. A bench-top version of the new mechanical delinter was built and evaluated to determine operational speeds...

  10. What Top Management Expects from the Communicator.

    ERIC Educational Resources Information Center

    Fegley, Robert L.

    Top corporate management requires communications departments that maintain credibility with the public by developing the following qualities: integrity established through consistent and honest messages; accuracy based on solid research; authority derived from an understanding of the subject and from drawing on appropriate expertise; a…

  11. The Top 100: Bachelor's Degrees Conferred

    ERIC Educational Resources Information Center

    Borden, Victor M. H.

    2012-01-01

    This article presents the Top 100 institutions that conferred the most bachelor's degrees to students of color in academic year 2010-2011. The data for this analysis are collected from all U.S. postsecondary institutions through the completions survey of the Integrated Postsecondary Education Data System (IPEDS) maintained by the National Center…

  12. The Top 100: Interpreting the Data.

    ERIC Educational Resources Information Center

    Borden, Victor M. H.

    1999-01-01

    The sources and structure of data reported in the annual "Top 100" list of colleges and universities conferring the highest numbers of degrees to students of color are described, and the use of the data to make comparisons between historically black and traditionally white institutions is explained. Some trends in the eight-year history of the…

  13. The Top 100 Associate Degrees Conferred

    ERIC Educational Resources Information Center

    Borden, Victor M. H.

    2010-01-01

    Nearly 250,000 students of color received associate degrees in academic year 2008-09. This represents 30 percent of all associate degree recipients, which is just slightly below the 33 percent representation of these racial/ethnic groups in the general U.S. population. In this edition of the Top 100 series, researchers highlight the institutions…

  14. The Top 100 Bachelor's Degree Conferred

    ERIC Educational Resources Information Center

    Borden, Victor M. H.

    2010-01-01

    Each year in the Top 100 series, researchers highlight the institutions that confer the most degrees to students of color. In this edition, they focus on the most prevalent degree conferred: the bachelor's degree. Among the types of colleges and universities that they examine--those that have Title IV status (recognized by the U.S. Department of…

  15. More Top Students Answer the Ministry's Call

    ERIC Educational Resources Information Center

    Supiano, Beckie

    2008-01-01

    In an effort to help reverse a decades-long decline in the number of top students entering seminaries, the Lilly Endowment invited colleges to compete for grants to be used for three related purposes: (1) to help students explore the relationship between faith and work; (2) to encourage talented students to consider entering Christian ministry;…

  16. Top-Ten IT Issues: 2009

    ERIC Educational Resources Information Center

    Agee, Anne Scrivener; Yang, Catherine

    2009-01-01

    This article presents the top-ten IT-related issues in terms of strategic importance to the institution, as revealed by the tenth annual EDUCAUSE Current Issues Survey. These IT-related issues include: (1) Funding IT; (2) Administrative/ERP Information Systems; (3) Security; (4) Infrastructure/Cyberinfrastructure; (5) Teaching and Learning with…

  17. A Top Physicist Turns to Teaching

    ERIC Educational Resources Information Center

    Bollag, Burton

    2007-01-01

    This article describes how a top physicist took charge of reforming undergraduate science education at the University of British Columbia. Carl E. Wieman, the 2001 Nobel Prize winner in Physics, gave up his research career to devote himself to improving the way college science is taught. Wieman is heading up a $10.2 million science education…

  18. Top-Ten IT Issues, 2011

    ERIC Educational Resources Information Center

    Ingerman, Bret L.; Yang, Catherine

    2011-01-01

    The results of the twelfth annual EDUCAUSE Current Issues Survey reflect the everyday balancing act that IT leaders need to perform. Many of the issues show the need for continued and thoughtful long-range planning, yet new issues have also risen quickly to the top, requiring nimbleness in both thought and act. Administered by the EDUCAUSE Current…

  19. America's Star Libraries: Top-Rated Libraries

    ERIC Educational Resources Information Center

    Lance, Keith Curry; Lyons, Ray

    2009-01-01

    "Library Journal"'s national rating of public libraries, the "LJ" Index of Public Library Service 2009, Round 2, identifies 258 "star" libraries. Created by Keith Curry Lance and Ray Lyons and based on 2007 data from the IMLS, it rates 7,268 public libraries. The top libraries in each group get five, four, or three stars. All included libraries,…

  20. Top-Ten IT Issues, 2010

    ERIC Educational Resources Information Center

    Ingerman, Bret L.; Yang, Catherine

    2010-01-01

    The eleventh annual EDUCAUSE Current Issues Survey shows some very familiar themes among the top-ten IT issues of strategic importance to technology leaders in higher education. Indeed, all ten of the issues from the 2009 survey are back, albeit in a slightly different order. In addition, Strategic Planning returns as an issue of renewed…

  1. Top Tips for Buying Telecommunication Services.

    ERIC Educational Resources Information Center

    Linder, Jeff

    2001-01-01

    Examines top regulatory issues and other unique issues resulting from this regulatory overlay when negotiating for corporate telecom services. Issues cover such topics as tariffs, rate negotiation, exclusivity provisions, revenue commitments, mid-term negotiations, service-level agreements, and dispute resolution. (GR)

  2. Top Down proteomics: Facts and perspectives

    SciTech Connect

    Catherman, Adam D.; Skinner, Owen S.; Kelleher, Neil L.

    2014-03-21

    Highlights: • Top Down versus Bottom Up proteomics analysis. • Separations methods for Top Down proteomics. • Developments in mass spectrometry instrumentation and fragmentation. • Native mass spectrometry. - Abstract: The rise of the “Top Down” method in the field of mass spectrometry-based proteomics has ushered in a new age of promise and challenge for the characterization and identification of proteins. Injecting intact proteins into the mass spectrometer allows for better characterization of post-translational modifications and avoids several of the serious “inference” problems associated with peptide-based proteomics. However, successful implementation of a Top Down approach to endogenous or other biologically relevant samples often requires the use of one or more forms of separation prior to mass spectrometric analysis, which have only begun to mature for whole protein MS. Recent advances in instrumentation have been used in conjunction with new ion fragmentation using photons and electrons that allow for better (and often complete) protein characterization on cases simply not tractable even just a few years ago. Finally, the use of native electrospray mass spectrometry has shown great promise for the identification and characterization of whole protein complexes in the 100 kDa to 1 MDa regime, with prospects for complete compositional analysis for endogenous protein assemblies a viable goal over the coming few years.

  3. Correlating Top Agency Success with Educational Background.

    ERIC Educational Resources Information Center

    Donnelly, William J.

    1992-01-01

    Investigates whether there is any correlation between successful advertising agency careers and undergraduate education. Finds that the educational tracks pursued by executives of the top 50 advertising agencies are so varied and remarkably evenly distributed that educational background appears to have little, if any, to do with success in…

  4. The Top American Indian Degree Producers

    ERIC Educational Resources Information Center

    Diverse: Issues in Higher Education, 2012

    2012-01-01

    Each year, "Diverse: Issues In Higher Education" publishes lists of the Top 100 producers of associate, bachelor's and graduate degrees awarded to minority students based on research conducted by Dr. Victor M.H. Borden, professor of educational leadership and policy studies at the Indiana University Bloomington. This year, Diverse staff continue…

  5. The Top 100 Bachelor's Degrees Conferred

    ERIC Educational Resources Information Center

    Borden, Victor M. H.

    2011-01-01

    This article presents this year's Top 100 institutions that conferred the most bachelor's degrees to students of color in academic year 2009-2010. It shows the total number of bachelor's degrees for a specific minority group or for total minorities, with subtotals for women and men in that ethnic group. The author also includes the prior year…

  6. Race to Top Now Faces Acid Test

    ERIC Educational Resources Information Center

    Cavanagh, Sean

    2010-01-01

    With the conclusion of the second round of the federal Race to the Top competition, states across the country--winners and losers alike--are vowing to move forward with ambitious plans to reshape teacher-evaluation systems, fix struggling schools, revamp antiquated data systems, and make other changes aimed at raising student achievement. Yet…

  7. Race to Top Round Two Heating Up

    ERIC Educational Resources Information Center

    McNeil, Michele

    2010-01-01

    With the second-round deadline for federal Race to the Top Fund grants less than six weeks away, states are rushing to raise the stakes on their education reform plans as they fight over the remaining $3.4 billion in prize money. But in doing so, states from Massachusetts to Colorado are tangling with their teachers' unions as they test how far…

  8. Organic crop production's top research priority: Pestiphytology

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Pestiphytology is the study of pest plants, commonly referred to as weeds. In a recent national survey, weed research was designated as the top research priority by organic producers. Manual weed control is a costly practice that can quickly decrease return on investment, while the absence of weed...

  9. Top-Ten IT Issues, 2012

    ERIC Educational Resources Information Center

    Grajek, Susan

    2012-01-01

    In 2011, "EDUCAUSE" appointed a research panel of IT leaders from nineteen representative member institutions to both identify and prioritize the top IT issues facing their institutions. In two focus group sessions in September and October 2011, the panel members were asked the question: "What is the single-biggest IT-related issue currently…

  10. States Press Race to Top Blueprints

    ERIC Educational Resources Information Center

    Cavanagh, Sean

    2010-01-01

    States are pushing ahead with efforts to make sweeping changes to education policy through the Race to the Top program, despite some of them having seen individual schools and districts back out of the process because of concerns over the time and money required to make those plans a reality. The Obama administration has envisioned Race to the…

  11. Tall tower or mountain top measurements?

    NASA Astrophysics Data System (ADS)

    Bamberger, Ines; Eugster, Werner; Oney, Brian; Brunner, Dominik; Leuenberger, Markus; Schanda, Rüdiger; Henne, Stephan; Buchmann, Nina

    2014-05-01

    Resolving the regional transport and distribution of greenhouse gases in the troposphere is a key topic that challenges both modelers and experimentalists. A dense network of measurement stations would be required, in particular including measurements at high elevation to better represent the entire lower troposphere, and not only small-scale local conditions in the near-surface atmosphere. While this can be achieved by tall towers, also mountain top stations (e.g. Schauinsland, Brocken) and other stations at high elevation (e.g., Mouna Loa, Jungfraujoch) are often appropriate, due to their extended concentration footprint. However, especially over complex, mountainous terrain, the transport of atmospheric gases and their spatio-temporal distribution is difficult to predict due to the development of thermally induced local wind patterns and boundary layer processes. Therefore, the main goal of our study is to test to what extend boundary layer processes at the surface and local wind patterns close to the ground at a mountain top site influence the ambient greenhouse gas patterns compared to measurements taken at a similar altitude but at a tall tower site. To this end we use measurements from the Zugerberg mountain top station, located at a pre-Alpine mountain ridge (987 m a.s.l., 4 m above ground) exposed to the prevailing synoptic winds in Switzerland, and compare these measurements with a neighboring tall tower site (Beromünster radio broadcast tower with its top at 1014 m a.s.l., 217 m above local ground level, and ≡500 m above the Swiss Plateau). The Beromünster tall tower is located at a distance of only 30 km from the mountain top station as the bird flies, and hence a direct comparison minimizes confounding factors that are not related to the tall tower vs. mountain top position of the measurements. Both stations are part of the CarboCount CH greenhouse gas observation network (http://www.carbocount.ch) initiated for long-term monitoring and modeling of

  12. Recent Results of Top Quark Physics from the Tevatron

    SciTech Connect

    Peters, R. Y.

    2015-07-09

    Twenty years after its discovery in 1995 by the CDF and D0 collaborations at the Tevatron proton-antiproton collider at Fermilab, the top quark still undergoes intensive studies at the Tevatron and the LHC at CERN. In this article, recent top quark physics results from CDF and D0 are reported. In particular, measurements of single top quark and double top quark production, the $t\\bar{t}$ forward-backward asymmetry and the top quark mass are discussed.

  13. 5. VIEW OF TIP TOP WITH FAR RIGHT SADDLE PROVIDING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. VIEW OF TIP TOP WITH FAR RIGHT SADDLE PROVIDING ORIENTATION FOR THE GENERAL DIRECTION TO NOTTINGHAM. CAMERA POINTED SOUTH-SOUTHWEST. NORTH SIDE OF TIP TOP BUILDING IS VISIBLE. (RUN STRAIGHT EDGE FROM LOWER LEFT CORNER TO TOP CENTER OF PRINT; TIP TOP LOCATED LIGHT AREA) ONTARIO IS LOCATED BELOW AND RIGHT OF TIP TOP. - Florida Mountain Mining Sites, Silver City, Owyhee County, ID

  14. Magnetismo Molecular (Molecular Magentism)

    SciTech Connect

    Reis, Mario S; Moreira Dos Santos, Antonio F

    2010-07-01

    The new synthesis processes in chemistry open a new world of research, new and surprising materials never before found in nature can now be synthesized and, as a wonderful result, observed a series of physical phenomena never before imagined. Among these are many new materials the molecular magnets, the subject of this book and magnetic properties that are often reflections of the quantum behavior of these materials. Aside from the wonderful experience of exploring something new, the theoretical models that describe the behavior these magnetic materials are, in most cases, soluble analytically, which allows us to know in detail the physical mechanisms governing these materials. Still, the academic interest in parallel this subject, these materials have a number of properties that are promising to be used in technological devices, such as in computers quantum magnetic recording, magnetocaloric effect, spintronics and many other devices. This volume will journey through the world of molecular magnets, from the structural description of these materials to state of the art research.

  15. PREFACE: 5th International Workshop on Top Quark Physics (TOP2012)

    NASA Astrophysics Data System (ADS)

    Salamanna, G.; Boisvert, V.; Cerrito, L.; Khan, A.; Moretti, S.; Owen, M.; Schwanenberger, C.

    2013-07-01

    The 5th International Workshop on Top Quark Physics (TOP 2012) took place in Winchester, UK, from the 16-21 September. It gathered students as well as people active in the top quark sector and provided a framework to highlight the newest results and matters related to top quark physics. Discovered in 1995, the top quark is the sixth and heaviest of all quarks, and it is the only one with a lifetime short enough to be observed 'naked'. This makes it an important testing ground in the search for new physics. In fact, the fact of its mass being so much larger than the other quarks, hints at its special role in the Higgs mechanism. For the same reason, in many models of New Physics, new heavy resonances are expected to couple mostly with top quarks. Even if no new particles are observed, the direct correlation between its angular momentum and that of its detectable decay products allows us to probe indirectly New Physics in action when top quarks are created. In this edition of the TOP conference series, for the first time, the agenda was equally balanced between 'traditional' measurements and the now vast number of searches for physics BSM in the top quark sector, thanks mostly to the amount of data collected at the LHC in its Run I. New results were presented by both the Tevatron and the LHC collaborations: improved ttbar and single top cross-section measurements, refined techniques to measure the top quark mass and a large number of results on properties such as spin correlation and W boson polarization in top quark decays were shown. More technical discussions on the experimental issues, both from the detector and the simulation side also took place, drawing together experimentalists and theorists. Reviews of the latest results on ttbar asymmetry both from CDF and D0 and from ATLAS and CMS were shown, and theorists active in the field made some interesting points on this hot topic. Additionally, results on the search for fourth generation fermions and new

  16. Targeting TopBP1 at a convergent point of multiple oncogenic pathways for cancer therapy

    PubMed Central

    Chowdhury, Pinki; Lin, Gregory E.; Liu, Kang; Song, Yongcheng; Lin, Fang-Tsyr; Lin, Weei-Chin

    2014-01-01

    The progression of many solid tumors is driven by de-regulation of multiple common pathways, particularly Rb, PI (3) K/Akt and p53. Prior studies identified TopBP1as a key mediator for the oncogenic gain-of-function activities of mutant p53 (mutp53) in cancer. In Akt-hyperactive cancer, TopBP1 forms oligomers and represses E2F1-dependent apoptosis. Here we perform a molecular docking screening and identify a lead compound, calcein, capable of blocking TopBP1 oligomerization and p53 binding, resulting in re-activation of E2F1-dependent apoptosis and blockade of mutp53 gain-of-function. Calcein AM, the cell permeable derivative of calcein, shows significant anti-tumor activity in a wide-spectrum of cultured cancer cells harboring high TopBP1 levels. These biochemical findings are recapitulated in breast cancer xenograft models. Thus, our study provides proof-of-concept evidence for targeting TopBP1, a convergent point of multiple pathways, as a cancer therapy. PMID:25400145

  17. The heavy top quark and supersymmetry

    SciTech Connect

    Hall, L.J. |

    1996-05-08

    Three aspects of supersymmetric theories are discussed: electroweak symmetry breaking, the issues of flavor, and gauge unification. The heavy top quark plays an important, sometimes dominant, role in each case. Additional symmetries lead to extensions of the standard model which can provide an understanding for many of the outstanding problems of particle physics. A broken supersymmetric extension of spacetime allows electroweak symmetry breaking to follow from the dynamics of the heavy top quark; an extension of isospin provides a constrained framework for understanding the pattern of quark and lepton masses; and a grand unified extension of the standard model gauge group provides an elegant understanding of the gauge quantum numbers of the components of a generation. Experimental signatures for each of these additional symmetries are discussed.

  18. TOP500 Supercomputers for November 2002

    SciTech Connect

    Strohmaier, Erich; Meuer, Hans W.; Dongarra, Jack; Simon, Horst D.

    2002-11-15

    20th Edition of TOP500 List of World's Fastest Supercomputers Released MANNHEIM, Germany; KNOXVILLE, Tenn.;&BERKELEY, Calif. In what has become a much-anticipated event in the world of high-performance computing, the 20th edition of the TOP500 list of the world's fastest supercomputers was released today (November 15, 2002). The Earth Simulator supercomputer installed earlier this year at the Earth Simulator Center in Yokohama, Japan, is with its Linpack benchmark performance of 35.86 Tflop/s (trillions of calculations per second) retains the number one position. The No.2 and No.3 positions are held by two new, identical ASCI Q systems at Los Alamos National Laboratory (7.73Tflop/s each). These systems are built by Hewlett-Packard and based on the Alpha Server SC computer system.

  19. Kodiak seamount not flat-topped.

    PubMed

    Hamilton, E L; von Huene, R E

    1966-12-01

    Earlier surveys in the Aleutian Trench southeast of Kodiak Island, Alaska, indicated that Kodiak Seamount had a flat top and was a tablemount or guyot. This seamount is of special significance because it has been supposed that its surface was eroded at the same time as those of a line of guyots to the southeast. If so, its present position in the axis of the Aleutian Trench indicates that the line of guyots was formed before the trench. A two-part survey in 1965 showed that Kodiak Seamount is not flat-topped, and should be eliminated from the category of guyots. Reflection profiling records indicate that the seamount was formed before the adjacent sediments were deposited, and that the small trough, or moat, on the south side is a depositional feature probably formed by a scouring effect or by the acceleration of turbidity currents around the base of the mount. PMID:17770303

  20. The heavy top quark and supersymmetry

    SciTech Connect

    Hall, L.J. |

    1997-01-01

    Three aspects of supersymmetric theories are discussed: electroweak symmetry breaking, the issues of flavor, and gauge unification. The heavy top quark plays an important, sometimes dominant, role in each case. Additional symmetries lead to extensions of the Standard Model which can provide an understanding for many of the outstanding problems of particle physics. A broken supersymmetric extension of spacetime allows electroweak symmetry breaking to follow from the dynamics of the heavy top quark; an extension of isospin provides a constrained framework for understanding the pattern of quark and lepton masses; and a grand unified extension of the Standard Model gauge group provides an elegant understanding of the gauge quantum numbers of the components of a generation. Experimental signatures for each of these additional symmetries are discussed.

  1. TOP500 Supercomputers for June 2003

    SciTech Connect

    Strohmaier, Erich; Meuer, Hans W.; Dongarra, Jack; Simon, Horst D.

    2003-06-23

    21st Edition of TOP500 List of World's Fastest Supercomputers Released MANNHEIM, Germany; KNOXVILLE, Tenn.;&BERKELEY, Calif. In what has become a much-anticipated event in the world of high-performance computing, the 21st edition of the TOP500 list of the world's fastest supercomputers was released today (June 23, 2003). The Earth Simulator supercomputer built by NEC and installed last year at the Earth Simulator Center in Yokohama, Japan, with its Linpack benchmark performance of 35.86 Tflop/s (teraflops or trillions of calculations per second), retains the number one position. The number 2 position is held by the re-measured ASCI Q system at Los Alamos National Laboratory. With 13.88 Tflop/s, it is the second system ever to exceed the 10 Tflop/smark. ASCIQ was built by Hewlett-Packard and is based on the AlphaServerSC computer system.

  2. Top quark and electroweak results from CDF

    SciTech Connect

    Sandra Leone

    2003-11-04

    In 2001 the Tevatron run II began, after a five year period of significant upgrade of the accelerator itself and of the experiments CDF and D0. After a detector commissioning run, the CDF experiment is now taking high quality data with all subsystems functional. We report in this talk the first preliminary CDF results on top quark and W/Z boson properties, based on run II data. The top quark, discovered in 1995 at the Tevatron, has proven to be a very interesting particle. Its properties allow to perform stringent tests of the Standard Model (SM) and to search for new physics through a deviation from SM predictions. We give here some expectations of what Tevatron run II will ultimately provide to our understanding of matter.

  3. Top cross section measurement at CDF

    SciTech Connect

    Compostella, Gabriele; /INFN, CNAF /Padua U.

    2010-01-01

    This paper describes the latest measurements of the t{bar t} pair production cross section performed by the CDF Collaboration analyzing p{bar p} collisions at a center-of-mass energy of 1.96 TeV from Fermilab Tevatron, as presented at the XVIII International Workshop on Deep-Inelastic Scattering and Related Subjects. In order to test Standard Model predictions, several analysis methods are explored and all the top decay channels are considered, to better constrain the properties of the top quark and to search for possible sources of new physics affecting the pair production mechanism. Experimental results using an integrated luminosity up to 5.1 fb{sup -1} are presented.

  4. An informatic framework for decoding protein complexes by top-down mass spectrometry

    PubMed Central

    Skinner, Owen S.; Havugimana, Pierre C.; Haverland, Nicole A.; Fornelli, Luca; Early, Bryan P.; Greer, Joseph B.; Fellers, Ryan T.; Durbin, Kenneth R.; Do Vale, Luis H. F.; Melani, Rafael D.; Seckler, Henrique S.; Nelp, Micah T.; Belov, Mikhail E.; Horning, Stevan R.; Makarov, Alexander A.; LeDuc, Richard D.; Bandarian, Vahe; Compton, Philip D.; Kelleher, Neil L.

    2015-01-01

    Efforts to map the human protein interactome have resulted in information about hundreds to thousands of multi-protein assemblies housed in public repositories, but the molecular characterization and stoichiometry of their protein subunits remains largely unknown. Here, we combined the CORUM and UniProt databases to create candidates for an error-tolerant search engine designed for hierarchical top-down analyses, identification, and scoring of multi-proteoform complexes by native mass spectrometry. PMID:26780093

  5. An informatic framework for decoding protein complexes by top-down mass spectrometry.

    PubMed

    Skinner, Owen S; Havugimana, Pierre C; Haverland, Nicole A; Fornelli, Luca; Early, Bryan P; Greer, Joseph B; Fellers, Ryan T; Durbin, Kenneth R; Do Vale, Luis H F; Melani, Rafael D; Seckler, Henrique S; Nelp, Micah T; Belov, Mikhail E; Horning, Stevan R; Makarov, Alexander A; LeDuc, Richard D; Bandarian, Vahe; Compton, Philip D; Kelleher, Neil L

    2016-03-01

    Efforts to map the human protein interactome have resulted in information about thousands of multi-protein assemblies housed in public repositories, but the molecular characterization and stoichiometry of their protein subunits remains largely unknown. Here, we report a computational search strategy that supports hierarchical top-down analysis for precise identification and scoring of multi-proteoform complexes by native mass spectrometry. PMID:26780093

  6. Race to Top Enters Home Stretch

    ERIC Educational Resources Information Center

    McNeil, Michele; Maxwell, Lesli A.

    2010-01-01

    When 16 finalists come to Washington next week to make their final pitches in the $4 billion Race to the Top competition, most can expect to go home empty-handed. U.S. Secretary of Education Arne Duncan, in announcing the finalists last week, said that no more than $2 billion will be divided among "very few winners" when the awards are given out…

  7. VEHICLE ASSEMBLY BUILDING [VAB] & TOPPING OFF CEREMONIES

    NASA Technical Reports Server (NTRS)

    1965-01-01

    Dr. Kurt H. Debus, KSC's first director, makes a brief speech during the topping off ceremonies for the Vehicle Assembly Building held on April 14, 1965. In the foreground is the 38- foot-long, four-ton steel beam signed by thousands of KSC employees and construction workers. The beam was hoisted to the tope of the 525-foot-tall structure and put in place to complete the building's steel skeleton.

  8. Slow Pace for Race to Top Spending

    ERIC Educational Resources Information Center

    McNeil, Michele

    2012-01-01

    Almost two years into the federal Race to the Top program, states are spending their shares of the $4 billion prize at a snail's pace--a reflection of the challenges the 12 winners face as they try to get ambitious education improvement plans off the ground. Through the end of March, the 11 states and the District of Columbia had spent just 14…

  9. The myth of the top management team.

    PubMed

    Katzenbach, J R

    1997-01-01

    Companies all across the economic spectrum are making use of teams. They go by a variety of names and can be found at all levels. In fact, you are likely to find the group at the very top of an organization professing to be a team. But even in the best of companies, a so-called top team seldom functions as a real team. Real teams must follow a well-defined discipline to achieve their performance potential. And performance is the key issue--not the fostering of "team values" such as empowerment, sensitivity, or involvement. In recent years, the focus on performance was lost in many companies. Even today, CEOs and senior executives often see few gains in performance from their attempts to become more teamlike. Nevertheless, a team effort at the top can be essential to capturing the highest performance results possible--when the conditions are right. Good leadership requires differentiating between team and nonteam opportunities, and then acting accordingly. Three litmus tests must be passed for a team at the top to be effective. First, the team must shape collective work-products--these are tangible performance results that the group can achieve working together that surpass what the team members could have achieved working on their own. Second, the leadership role must shift, depending on the task at hand. And third, the team's members must be mutually accountable for the group's results. When these criteria can be met, senior executives should come together to achieve real team performance. When the criteria cannot be met, they should rely on the individual leadership skills that they have honed over the years. PMID:10174799

  10. The Top 10 Lists of 2011

    ERIC Educational Resources Information Center

    American School & University, 2011

    2011-01-01

    This article presents lists of the top ten schools with most students, largest enrollment, and other categories for 2011 in the U.S. The school districts with most student for 2010-2011 are New York City with 1,043,886 followed by Los Angeles with 667,251, Chicago with 403,770 and down to the 10th spot Orange County (Fla.) with 175,986. The…

  11. Top physics at the Tevatron Collider

    SciTech Connect

    Margaroli, Fabrizio; /Purdue U.

    2007-10-01

    The top quark has been discovered in 1995 at the CDF and DO experiments located in the Tevatron ring at the Fermilab laboratory. After more than a decade the Tevatron collider, with its center-of-mass energy collisions of 1.96 TeV, is still the only machine capable of producing such exceptionally heavy particle. Here I present a selection of the most recent CDF and DO measurements performed analyzing {approx} 1 fb{sup -1} of integrated luminosity.

  12. Charm, beauty and top at HERA

    NASA Astrophysics Data System (ADS)

    Behnke, O.; Geiser, A.; Lisovyi, M.

    2015-09-01

    Results on open charm and beauty production and on the search for top production in high-energy electron-proton collisions at HERA are reviewed. This includes a discussion of relevant theoretical aspects, a summary of the available measurements and measurement techniques, and their impact on improved understanding of QCD and its parameters, such as parton density functions and charm- and beauty-quark masses. The impact of these results on measurements at the LHC and elsewhere is also addressed.

  13. Rare top quark decays in extended models

    SciTech Connect

    Gaitan, R.; Miranda, O. G.; Cabral-Rosetti, L. G.

    2006-09-25

    Flavor changing neutral currents (FCNC) decays t {yields} H0 + c, t {yields} Z + c, and H0 {yields} t + c-bar are discussed in the context of Alternative Left-Right symmetric Models (ALRM) with extra isosinglet heavy fermions where FCNC decays may take place at tree-level and are only suppressed by the mixing between ordinary top and charm quarks, which is poorly constraint by current experimental values. The non-manifest case is also briefly discussed.

  14. Observation of Single Top Quark Production

    SciTech Connect

    Gerber, Cecilia E.; /Illinois U., Chicago

    2009-09-01

    The author reports on the observation of electroweak production of single top quarks in p{bar p} collisions at {radical}s = 1.96 Tev using 2.3 fb{sup -1} of data collected with the D0 detector at the fermilab Tevatron Collider. Using events containing an isolated electron or muon, missing transverse energy, two, three or four jets, with one or two of them identified as originating from the fragmentation of a b quark, the measured cross section for the process p{bar p} {yields} tb + X, tqb + X is 3.94 {+-} 0.88 pb (for a top quark mass of 170 GeV). the probability to measure a cross section at this value or higher in the absence of signal is 2.5 x 10{sup -7}, corresponding to a 5.0 standard deviation significance. Using the same dataset, the measured cross sections for the t- and the s-channel processes when determined simultaneously with no assumption on their relative production rate are 3.14{sub -0.80}{sup +0.94} pb and 1.05 {+-} 0.81 pb respectively, consistent with standard model expectations. The measured t-channel cross section has a significance of 4.8 standard deviations, representing the first evidence for the production of an individual single top process to be detected.

  15. Status of the DO top search

    SciTech Connect

    Li-Demarteau, Q.; DO Collaboration

    1994-09-01

    Preliminary new results on the top quark search with the DO experiment in {bar p}p collisions at {radical}s = 1.8 TeV for an integrated luminosity of 15.2 {plus_minus} 1.8 pb{sup {minus}1} are reported. In this new analysis, which is optimized for high mass top search, a total of seven candidate events in the electron and muon dilepton decay channels (t{bar t} {yields} e{mu}, ee and {mu}{mu}), single lepton decay channels (t{bar t} {yields} e + jets and t{bar t} {yields} {mu} + jets) without b tagging and single electron decay channel (t{bar t} {yields} e + jets) with b tagging have been observed. The estimated background is 4.7 {plus_minus} 1.0 events. If we assume the top quark has a mass of 180 GeV/c{sup 2}, a t{bar t} production cross section of 3.2 {plus_minus} 3.9 pb with upper limit of 13 pb at 95% C.L. is obtained.

  16. Tracking down hyper-boosted top quarks

    DOE PAGESBeta

    Larkoski, Andrew J.; Maltoni, Fabio; Selvaggi, Michele

    2015-06-05

    The identification of hadronically decaying heavy states, such as vector bosons, the Higgs, or the top quark, produced with large transverse boosts has been and will continue to be a central focus of the jet physics program at the Large Hadron Collider (LHC). At a future hadron collider working at an order-of-magnitude larger energy than the LHC, these heavy states would be easily produced with transverse boosts of several TeV. At these energies, their decay products will be separated by angular scales comparable to individual calorimeter cells, making the current jet substructure identification techniques for hadronic decay modes not directlymore » employable. In addition, at the high energy and luminosity projected at a future hadron collider, there will be numerous sources for contamination including initial- and final-state radiation, underlying event, or pile-up which must be mitigated. We propose a simple strategy to tag such "hyper-boosted" objects that defines jets with radii that scale inversely proportional to their transverse boost and combines the standard calorimetric information with charged track-based observables. By means of a fast detector simulation, we apply it to top quark identification and demonstrate that our method efficiently discriminates hadronically decaying top quarks from light QCD jets up to transverse boosts of 20 TeV. Lastly, our results open the way to tagging heavy objects with energies in the multi-TeV range at present and future hadron colliders.« less

  17. Tracking down hyper-boosted top quarks

    SciTech Connect

    Larkoski, Andrew J.; Maltoni, Fabio; Selvaggi, Michele

    2015-06-05

    The identification of hadronically decaying heavy states, such as vector bosons, the Higgs, or the top quark, produced with large transverse boosts has been and will continue to be a central focus of the jet physics program at the Large Hadron Collider (LHC). At a future hadron collider working at an order-of-magnitude larger energy than the LHC, these heavy states would be easily produced with transverse boosts of several TeV. At these energies, their decay products will be separated by angular scales comparable to individual calorimeter cells, making the current jet substructure identification techniques for hadronic decay modes not directly employable. In addition, at the high energy and luminosity projected at a future hadron collider, there will be numerous sources for contamination including initial- and final-state radiation, underlying event, or pile-up which must be mitigated. We propose a simple strategy to tag such "hyper-boosted" objects that defines jets with radii that scale inversely proportional to their transverse boost and combines the standard calorimetric information with charged track-based observables. By means of a fast detector simulation, we apply it to top quark identification and demonstrate that our method efficiently discriminates hadronically decaying top quarks from light QCD jets up to transverse boosts of 20 TeV. Lastly, our results open the way to tagging heavy objects with energies in the multi-TeV range at present and future hadron colliders.

  18. Top quark production dynamics in QCD

    SciTech Connect

    Berger, E.L.; Contopanagos, H.

    1995-12-31

    A calculation of the total cross section for top quark production in hadron-hadron collisions is presented based on an all-orders perturbative resummation of initial-state gluon radiative contributions to the basic quantum chromodynamics subprocesses. Principal-value resummation is used to evaluate all relevant large threshold contributions. In this method there are no arbitrary infrared cutoffs, and the perturbative regime of applicability is well defined, two attributes that significantly reduce the estimated uncertainty of the results. For p{bar p} collisions at center-of-mass energy {radical}s = 1.8 TeV and a top mass of 175 GeV, we obtain {sigma}(t{bar t}) = 5.52{sup +0.07}{sub {minus}0.45}pb, in agreement with experiment. Predicted cross sections are provided as a function of top mass in p{bar p} collisions at {radical}s = 2.0 TeV and in pp at CERN LHC energies.

  19. TOP500 Sublist for November 2001

    SciTech Connect

    Strohmaier, Erich; Meuer, Hans W.; Dongarra, Jack J.; Simon,Horst D.

    2001-11-09

    18th Edition of TOP500 List of World's Fastest Supercomputers Released MANNHEIM, GERMANY; KNOXVILLE, TENN.; BERKELEY, CALIF. In what has become a much-anticipated event in the world of high-performance computing, the 18th edition of the TOP500 list of the world's fastest supercomputers was released today (November 9, 2001). The latest edition of the twice-yearly ranking finds IBM as the leader in the field, with 32 percent in terms of installed systems and 37 percent in terms of total performance of all the installed systems. In a surprise move Hewlett-Packard captured the second place with 30 percent of the systems. Most of these systems are smaller in size and as a consequence HP's share of installed performance is smaller with 15 percent. This is still enough for second place in this category. SGI, Cray and Sun follow in the number of TOP500 systems with 41 (8 percent), 39 (8 percent), and 31 (6 percent) respectively. In the category of installed performance Cray Inc. keeps the third position with 11 percent ahead of SGI (8 percent) and Compaq (8 percent).

  20. Top quark physics at the Tevatron

    SciTech Connect

    Antonio Sidoti

    2004-03-17

    After the successful Run I of the Tevatron (1992-1996),with the top quark discovery, both CDF and D0 experiments were extensively upgraded to meet the challenges of the Tevatron Run II collider. The energy of p{bar p} collisions at the Tevatron was increased from {radical}s = 1.8 TeV to {radical}s = 1.96 TeV. t{bar t} production cross section is expected to increase by a factor of {approx} 30%. Major upgrades in the Tevatron accelerator chain will increase the Run II instantaneous luminosity: the goal is to achieve L = 5 - 20 x 10{sup 31} cm{sup 2}s{sup -1} while the highest luminosity reached up to now (September 2003) is 5.2 x 10{sup 31} cm{sup 2} s{sup -1}. In this paper we will present the top quark properties measured by both CDF and D0 with the first physics-quality data collected during the Run II (March 2002-January 2003). First we will review t{bar t} cross section measurements in the various decay channels; then top quark mass measurements will be presented.

  1. Dark decay of the top quark

    DOE PAGESBeta

    Kong, Kyoungchul; Lee, Hye -Sung; Park, Myeonghun

    2014-04-01

    We suggest top quark decays as a venue to search for light dark force carriers. Top quark is the heaviest particle in the standard model whose decays are relatively poorly measured, allowing sufficient room for exotic decay modes from new physics. A very light (GeV scale) dark gauge boson (Z') is a recently highlighted hypothetical particle that can address some astrophysical anomalies as well as the 3.6 σ deviation in the muon g-2 measurement. We present and study a possible scenario that top quark decays as t → b W + Z's. This is the same as the dominant topmore » quark decay (t → b W) accompanied by one or multiple dark force carriers. The Z' can be easily boosted, and it can decay into highly collimated leptons (lepton-jet) with large branching ratio. In addition, we discuss the implications for the Large Hadron Collider experiments including the analysis based on the lepton-jets.« less

  2. Measurements of top quark properties at the Tevatron collider

    SciTech Connect

    Margaroli, Fabrizio

    2011-05-01

    The discovery of the top quark in 1995 opened a whole new sector of investigation of the Standard Model; today top quark physics remains a key priority of the Tevatron program. Some of the measurements of top quark properties, for example its mass, will be a long-standing legacy. The recent evidence of an anomalously large charge asymmetry in top quark events suggests that new physics could couple preferably with top quarks. I will summarize this long chapter of particle physics history and discuss the road the top quark is highlighting for the LHC program.

  3. Terascale Optimal PDE Simulations (TOPS) Center

    SciTech Connect

    Pothen, Alex

    2006-08-23

    This report covers the period from Oct. 2002 to Sep. 2004 when Old Dominion University (ODU) was the lead institution for the TOPS ISIC, until in Oct. 2004 Columbia University replaced ODU as the lead institution. The TOPS members from ODU focused on various aspects of the linear and nonlinear solver infrastructure required by the partial differential equations simulation codes, working directly with SciDAC teams from the Fusion Energy Sciences program: the Center for Extended agnetohydrodynamic Modeling (CEMM) at Princeton, and with the Center for Magnetic Reconnection Studies (CMRS) at University of New Hampshire. With CEMM we worked with their MHD simulation code, called M3D, which is semi-implicit, requiring linear solves but no onlinear solves. We contributed several improvements to their current semi-implicit code. Among these was the use of multilevel reconditioning, which provides optimal scaling. This was done through the multigrid preconditioner available in Hypre, another major solver package available in TOPS. We also provided them direct solver functionality for their linear solves since they may be required for more accurate solutions in some regimes. With the CMRS group, we implemented a fully implicit parallel magnetic reconnection simulation code, built on top of PETSc. Our first attempt was a Krylov linear iteration (GMRES because of the lack of symmetry), within each nonlinear (Newton) iteration, with optimal multilevel preconditioning, using the geometric multigrid preconditioner from PETSc. However, for reasons that we have not yet fully understood, the multigrid preconditioner fails early in the simulation, breaking the outer Newton iteration. Much better results were obtained after switching from optimal multilevel preconditioning to suboptimal one level preconditioning. Our current code, based on the additive Schwartz preconditioner from in PETSc, with ILU on subdomains, scales reasonably well, while matching the output of the original

  4. Dynamics of a cliff top dune

    NASA Astrophysics Data System (ADS)

    Rasmussen, K. R.

    2012-12-01

    Morphological changes during more than 100 years have been investigated for a cliff-top dune complex at Rubjerg at the Danish North Sea coast. Here the lower 50 m of the cliff front is composed of Pleistocene steeply inclined floes of silt and clay with coarse sand in between which gives it a saw-tooth appearance. On top of this the dunes are found for several kilometres along the coastline. Due to erosion by the North Sea the cliff has retreated about 120 m between approximately 1880 and 1970 as indicated from two national surveys, and recent GPS-surveys indicate that erosion is continuing at a similar rate. Nevertheless the cliff top dune complex has survived, but its morphology has undergone some changed. The old maps indicate that around 1880 the dune complex was composed of several up to about 20 m high dunes streamlined in the East-West direction which is parallel to the prevailing wind direction. When protective planting started during the first half of the 20th Century the cliff top dunes gradually merged together forming a narrow, tall ridge parallel to the shore line with the highest part reaching about 90 m near 1970. In 1993 the highest points along the ridge was almost 95 m high, but then the protective planting was considerably reduced and recent annual GPS-surveys indicate that the dunes respond quickly to this by changing their morphology towards the original appearance. It is remarkable that despite the mass wasting caused by the constant erosion of the cliff front the dunes have remained more or less intact. Theoretical studies of hill flow indicate given the proper geometry of the cliff then suspension of even coarse grains can be a very effective agent for carrying sand from the exposed parts of the cliff front to and beyond the cliff-top. Mostly the sand grains are deposited within some hundred meters downwind of the cliff dune while silt is often carried more than 10 km inland. Field observations indicate that where the dislodged floes and

  5. Extension of the measurement, assignment, and fit of the rotational spectrum of the two-top molecule methyl acetate

    NASA Astrophysics Data System (ADS)

    Nguyen, Ha Vinh Lam; Kleiner, Isabelle; Shipman, Steven T.; Mae, Yoshiaki; Hirose, Kazue; Hatanaka, Shota; Kobayashi, Kaori

    2014-05-01

    New and previous spectroscopic data were recorded for the two-top molecule methyl acetate using five spectrometers in four different labs: a room temperature chirped-pulse Fourier transform microwave (FTMW) spectrometer in the frequency range from 8.7 to 26.5 GHz, two molecular beam FTMW spectrometers (2-40 GHz), a free jet absorption Stark-modulated spectrometer (60-78 GHz), and a room temperature millimeter-wave spectrometer (44-68 GHz). Approximately 800 new lines with J up to 40 and K up to 16 were assigned. In total, 1603 lines were fitted with 34 parameters using an internal rotation Hamiltonian in the Rho Axis Method (RAM) and the program BELGI-Cs-2tops to standard deviations close to the experimental uncertainties. More precise determinations of the top-top interaction and the J, K dependent parameters were carried out.

  6. 11. TIP TOP MINE. DETAIL OF TONGUE AND GROOVE INTERIOR ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. TIP TOP MINE. DETAIL OF TONGUE AND GROOVE INTERIOR SIDING IN LIVING QUARTERS. CAMERA POINTED EAST. - Florida Mountain Mining Sites, Tip Top Mine, West face Florida Mountain, approximately 150 feet below summit, Silver City, Owyhee County, ID

  7. 13. VIEW OF TOP CHORD CONNECTION, SHOWING DIAGONAL AND VERTICAL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. VIEW OF TOP CHORD CONNECTION, SHOWING DIAGONAL AND VERTICAL WEB MEMBERS AND TOP LATERAL BRACING, SOUTHEAST SPAN, LOOKING NORTHEAST - Linden Avenue Bridge, Spanning Purgatoire River on Linden Avenue, Trinidad, Las Animas County, CO

  8. 5. TIP TOP MINE. EAST SIDE OF STRUCTURE WITH COLLAPSED ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. TIP TOP MINE. EAST SIDE OF STRUCTURE WITH COLLAPSED ADIT. CAMERA POINTED WEST. - Florida Mountain Mining Sites, Tip Top Mine, West face Florida Mountain, approximately 150 feet below summit, Silver City, Owyhee County, ID

  9. 3. TIP TOP MINE. SOUTH SIDE OF HOUSE. CAMERA POINTED ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. TIP TOP MINE. SOUTH SIDE OF HOUSE. CAMERA POINTED NORTH-NORTHWEST. - Florida Mountain Mining Sites, Tip Top Mine, West face Florida Mountain, approximately 150 feet below summit, Silver City, Owyhee County, ID

  10. 6. TIP TOP MINE. DETAIL OF SIDING. SOUTHWEST CORNER OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. TIP TOP MINE. DETAIL OF SIDING. SOUTHWEST CORNER OF STRUCTURE. CAMERA POINTED NORTHEAST. - Florida Mountain Mining Sites, Tip Top Mine, West face Florida Mountain, approximately 150 feet below summit, Silver City, Owyhee County, ID

  11. 2. TIP TOP MINE. NORTH AND EAST SIDE OF HOUSE. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. TIP TOP MINE. NORTH AND EAST SIDE OF HOUSE. CAMERA POINTED SOUTH. - Florida Mountain Mining Sites, Tip Top Mine, West face Florida Mountain, approximately 150 feet below summit, Silver City, Owyhee County, ID

  12. 1. TIP TOP MINE. WEST SIDE OF STRUCTURE. CAMERA POINTED ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. TIP TOP MINE. WEST SIDE OF STRUCTURE. CAMERA POINTED EAST. - Florida Mountain Mining Sites, Tip Top Mine, West face Florida Mountain, approximately 150 feet below summit, Silver City, Owyhee County, ID

  13. 6. DETAIL OF BRIDGE BALUSTRADE, NORTH SIDE, TOP OF WASHINGTON ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. DETAIL OF BRIDGE BALUSTRADE, NORTH SIDE, TOP OF WASHINGTON MONUMENT VISIBLE AT TOP-CENTER. - Tidal Reservoir, Inlet Bridge, Ohio Drive, spanning Inlet of Tidal Basin, Washington, District of Columbia, DC

  14. 11. VIEW OF PIN CONNECTION, SOUTH WEB, SHOWING TOP CHORD, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. VIEW OF PIN CONNECTION, SOUTH WEB, SHOWING TOP CHORD, LATTICE BRACING, HIP VERTICAL, EYEBARS, TOP LATERAL BRACING, AND STRUTS, LOOKING SOUTH - Four Mile Bridge, Spanning Elk River on County Road 42, Steamboat Springs, Routt County, CO

  15. Molecular Plasmonics.

    PubMed

    Wilson, Andrew J; Willets, Katherine A

    2016-06-12

    In this review, we survey recent advances in the field of molecular plasmonics beyond the traditional sensing modality. Molecular plasmonics is explored in the context of the complex interaction between plasmon resonances and molecules and the ability of molecules to support plasmons self-consistently. First, spectroscopic changes induced by the interaction between molecular and plasmonic resonances are discussed, followed by examples of how tuning molecular properties leads to active molecular plasmonic systems. Next, the role of the position and polarizability of a molecular adsorbate on surface-enhanced Raman scattering signals is examined experimentally and theoretically. Finally, we introduce recent research focused on using molecules as plasmonic materials. Each of these examples is intended to highlight the role of molecules as integral components in coupled molecule-plasmon systems, as well as to show the diversity of applications in molecular plasmonics. PMID:27049633

  16. New molecular probes of vascular inflammation.

    PubMed

    Vrachimis, Alexis; Honold, Lisa; Faust, Andreas; Hermann, Sven; Schäfers, Michael

    2016-09-01

    New molecular imaging approaches featuring the assessment of inflammatory processes in the vascular wall on top of existing anatomic and functional vessel imaging procedures could emerge as decisive tools for the understanding and prevention of cardiovascular events. In this respect imaging approaches addressing specific molecular and cellular targets in atherosclerosis are of high interest. This review summarizes the rationale and current status of nuclear imaging probes which possess high translational potential. PMID:27280733

  17. Top-down vertical itemset mining

    NASA Astrophysics Data System (ADS)

    Sohrabi, Mohammad Karim; Ghods, Vahid

    2015-03-01

    Vertical itemset mining is an important frequent pattern mining problem with broad applications. It is challenging since one may need to examine a combinatorial explosive number of possible patterns of items of a dataset in a traditional horizontal algorithm. Since high dimensional datasets typically contain a large number of columns and a small number of rows, vertical itemset mining algorithms, which extract the frequent itemsets of dataset by producing all combination of rows ids, are a good alternative for horizontal algorithms in mining frequent itemsets from high dimensional dataset. Since a rowset can be simply produced from its subsets by adding a new row id to a sub rowset, many bottom up vertical itemset mining algorithms are designed and represented in the literature. However, bottom up vertical mining algorithms suffer from a main drawback. Bottom-up algorithms start the process of generating and testing of rowsets from the small rowsets and go on to the larger rowsets, whereas the small rowsets cannot produce a frequent itemsets because they contain less than minimum support threshold number of rows. In this paper, we described a new efficient vertical top down algorithm called VTD (Vertical Top Down) to conduct mining of frequent itemsets in high dimensional datasets. Our top down approach employed the minimum support threshold to prune the rowsets which any itemset could not be extracted from them. Several experiments on real bioinformatics datasets showed that VTD is orders of magnitude better than previous closed pattern mining algorithms. Our performance study showed that this algorithm outperformed substantially the best former algorithms.

  18. Altmetric: Top 50 dental articles in 2014.

    PubMed

    Kolahi, J; Khazaei, S

    2016-06-10

    Introduction Altmetrics is a new and emerging scholarly tool that measures online attention surrounding journal articles. Altmetric data resources include: policy documents, news outlets, blogs, online reference managers (eg Mendeley and CiteULike), post-publication peer-review forums (eg PubPeer and Publons), social media (eg Twitter, Facebook, Weibo, Google(+), Pinterest, Reddit), Wikipedia, sites running Stack Exchange (Q&A), and reviews on F1000 and YouTube.Methods To identify the top 50 dental articles in 2014, PubMed was searched using the following query "("2014/1/1"[PDAT]:"2014/12/31"[PDAT]) and jsubsetd[text]" in December, 2015. Consequently, all PubMed records were extracted and sent to Altmetric LLP (London, UK) as a CSV file for examination. Data were analysed by Microsoft Office Excel 2010 using descriptive statistics and charts.Results Using PubMed searches,15,132 dental articles were found in 2014. The mean Altmetric score of 50 top dental articles in 2014 was 69.5 ± 73.3 (95% CI: -74.14 to 213.14). The British Dental Journal (48%) and Journal of Dental Research (16%) had the maximum number of top articles. Twitter (67.13%), Mendeley (15.89%) and news outlets (10.92%) were the most popular altmetric data resources.Discussion Altmetrics are intended to supplement bibliometrics, not replace them. Altmetrics is a fresh and emerging arena for the dental research community. We believe that dental clinical practitioners, research scientists, research directors and journal editors must pay more attention to altmetrics as a new and rapid tool to measure the social impact of scholarly articles. PMID:27283563

  19. VEHICLE ASSEMBLY BUILDING [VAB] & TOPPING OFF CEREMONIES

    NASA Technical Reports Server (NTRS)

    1965-01-01

    Hundreds of construction workers, community leaders, and NASA and contractor employees were present on April 14, 1965 for a ceremony marking off the ''topping off'' of the Vehicle Assembly Building. Visible in this photo are the three Launch umbilical Towers then being constructed from which to launch the giant Saturn V rocket which would hurl Americans to the Moon during Project Apollo. The LUTs were 446-feet tall. They were modified to support the Space Shuttle program following completion of Saturn/Apollo related programs in the mid 1970s.

  20. Dynamical generation of the top quark mass

    NASA Astrophysics Data System (ADS)

    Popovic, Marko Berislav

    2002-09-01

    I study new physics theories in which the observed mass of the heaviest elementary particle, the top quark, is a result of a dynamical mechanism at the subatomic level. The same mechanism needs to explain the transition of the effective physical description at the largest space-time scales to that at smaller scales. This large-scale description is characterized by non-zero masses for most of the elementary particles and the existence of the familiar electromagnetic interactions. The description at smaller space-time scales is characterized by the presence of a richer set of fundamental interactions, including weak and hypercharge interactions, as well as no masses for the particles. As a minimal consequence of this transition, particle theories commonly predict the existence of a still unobserved particle, called the Higgs, at the largest scales. New physics considered in this thesis includes the following: (1) Models with new fundamental interactions that select the top quark and give an exclusive role to its dynamical mass generation mechanism. I propose one such model, discuss current experimental constraints, and suggest future tests of this idea. (2) Models with new spin one-half particles, not sensitive to the weak interactions, that mix with ordinary particles, including the top quark. I discuss the phenomenology, i.e., analyze data from particle colliders, and set limits on the parameters of the models. (3) Models with new spin one-half particles, sensitive to the weak interactions, that mix with ordinary particles. I propose the model structure, discuss some of its phenomenology, and suggest further tests of this idea at linear particle accelerators. Finally, I analyze the connection between the Higgs mass (m H) and the space-time scale at which the above-mentioned transition occurs. Without introducing new physics at the smallest scales, I show that due to the very large top mass, the standard description with the Higgs particle fails at small scales

  1. Search for top and bottom squarks

    SciTech Connect

    C. Rott

    2003-10-15

    Searches for the lightest scalar top quark {bar t}{sub 1} and scalar bottom quark {bar b}{sub 1} performed at LEP2 with a center-of-mass energy of up to {radical}s = 209 GeV and at Tevatron using data collected at {radical}s = 1.8 TeV during Run I and at {radical}s = 1.96 TeV during Run II, are discussed. Different possible decay modes were considered and no evidence for any such signal was observed. Exclusion limits were extracted.

  2. Top Event Matrix Analysis Code System.

    Energy Science and Technology Software Center (ESTSC)

    2000-06-19

    Version 00 TEMAC is designed to permit the user to easily estimate risk and to perform sensitivity and uncertainty analyses with a Boolean expression such as produced by the SETS computer program. SETS produces a mathematical representation of a fault tree used to model system unavailability. In the terminology of the TEMAC program, such a mathematical representation is referred to as a top event. The analysis of risk involves the estimation of the magnitude ofmore » risk, the sensitivity of risk estimates to base event probabilities and initiating event frequencies, and the quantification of the uncertainty in the risk estimates.« less

  3. Cloud top remote sensing by airborne lidar

    NASA Technical Reports Server (NTRS)

    Spinhirne, J. D.; Hansen, M. Z.; Caudill, L. O.

    1982-01-01

    Observations of cloud top height, backscattering, and signal depolarization have been obtained by a lidar system operating onboard a high-altitude research aircraft. The transmitter for the cloud lidar system is a doubled Nd:YAG laser operating at 5 Hz. The system functions as a fully automated sensor under microprocessor control and operates from a nominal 19-km altitude. Measurements have been acquired over a wide variety of cloud cover in conjunction with passive visible and infrared measurements. Initial observation results are reported

  4. Cloud top remote sensing by airborne lidar.

    PubMed

    Spinhirne, J D; Hansen, M Z; Caudill, L O

    1982-05-01

    Observations of cloud top height, backscattering, and signal depolarization have been obtained by a lidar system operating onboard a high-altitude research aircraft. The transmitter for the cloud lidar system is a doubled Nd:YAG laser operating at 5 Hz. The system functions as a fully automated sensor under microprocessor control and operates from a nominal 19-km altitude. Measurements have been acquired over a wide variety of cloud cover in conjunction with passive visible and infrared measurements. Initial observation results are reported. PMID:20389897

  5. QCD coherence and the top quark asymmetry

    NASA Astrophysics Data System (ADS)

    Skands, Peter; Webber, Bryan; Winter, Jan

    2012-07-01

    Coherent QCD radiation in the hadroproduction of top quark pairs leads to a forward-backward asymmetry that grows more negative with increasing transverse momentum of the pair. This feature is present in Monte Carlo event generators with coherent parton showering, even though the production process is treated at leading order and has no intrinsic asymmetry before showering. In addition, depending on the treatment of recoils, showering can produce a positive contribution to the inclusive asymmetry. We explain the origin of these features, compare them in fixed-order calculations and the H erwig++, P ythia and S herpa event generators, and discuss their implications.

  6. Toward understanding the effect of top predators on ecosystems

    PubMed Central

    Lecomte, Nicolas; Ehrich, Dorothée; Ims, Rolf A

    2009-01-01

    To what extent top predators - carnivores at the top of food chains - drive or just respond to ecosystem dynamics is a central, but partially unresolved, question in ecology. In this report, we highlight how different research approaches employed in aquatic and terrestrial ecology may have a bearing on how the role of top predators in ecosystems is perceived. PMID:20948660

  7. Measuring the top Yukawa coupling at 100 TeV

    NASA Astrophysics Data System (ADS)

    Mangano, Michelangelo L.; Plehn, Tilman; Reimitz, Peter; Schell, Torben; Shao, Hua-Sheng

    2016-04-01

    We propose a measurement of the top Yukawa coupling at a 100 TeV hadron collider, based on boosted Higgs and top decays. We find that the top Yukawa coupling can be measured to 1%, with excellent handles for reducing systematic and theoretical uncertainties, both from side bands and from t\\bar{t}H/t\\bar{t}Z ratios.

  8. It's about Time: The Literacy TopPics Awards.

    ERIC Educational Resources Information Center

    And Others; Swafford, Jeanne

    1997-01-01

    Examines the last five years of articles in this journal to show what topics were most often written about (the "Top Picks" or "TopPics"). Discusses these results and makes recommendations that deserve considerable attention in the future. Notes that integrated language arts was a perennial TopPic. (SR)

  9. 49 CFR 229.71 - Clearance above top of rail.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Clearance above top of rail. 229.71 Section 229.71....71 Clearance above top of rail. No part or appliance of a locomotive except the wheels, flexible nonmetallic sand pipe extension tips, and trip cock arms may be less than 21/2 inches above the top of rail....

  10. 29 CFR 1960.54 - Training of top management officials.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 9 2013-07-01 2013-07-01 false Training of top management officials. 1960.54 Section 1960... PROGRAMS AND RELATED MATTERS Training § 1960.54 Training of top management officials. Each agency shall provide top management officials with orientation and other learning experiences which will enable them...

  11. 29 CFR 1960.54 - Training of top management officials.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 9 2011-07-01 2011-07-01 false Training of top management officials. 1960.54 Section 1960... PROGRAMS AND RELATED MATTERS Training § 1960.54 Training of top management officials. Each agency shall provide top management officials with orientation and other learning experiences which will enable them...

  12. 49 CFR 229.71 - Clearance above top of rail.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Clearance above top of rail. 229.71 Section 229.71....71 Clearance above top of rail. No part or appliance of a locomotive except the wheels, flexible nonmetallic sand pipe extension tips, and trip cock arms may be less than 21/2 inches above the top of rail....

  13. 29 CFR 1960.54 - Training of top management officials.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 9 2012-07-01 2012-07-01 false Training of top management officials. 1960.54 Section 1960... PROGRAMS AND RELATED MATTERS Training § 1960.54 Training of top management officials. Each agency shall provide top management officials with orientation and other learning experiences which will enable them...

  14. 49 CFR 229.71 - Clearance above top of rail.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Clearance above top of rail. 229.71 Section 229.71....71 Clearance above top of rail. No part or appliance of a locomotive except the wheels, flexible nonmetallic sand pipe extension tips, and trip cock arms may be less than 21/2 inches above the top of rail....

  15. 12. TIP TOP MINE. WOODEN STRUCTURE ASSOCIATED WITH CABLES IN ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. TIP TOP MINE. WOODEN STRUCTURE ASSOCIATED WITH CABLES IN ID-31-C-13 AND ID-31-C-14 LOCATED ON SLOPE JUST BELOW TIP TOP HOUSE. CAMERA IS POINTED NORTH-NORTHWEST. - Florida Mountain Mining Sites, Tip Top Mine, West face Florida Mountain, approximately 150 feet below summit, Silver City, Owyhee County, ID

  16. 29 CFR 1960.54 - Training of top management officials.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Training of top management officials. 1960.54 Section 1960... PROGRAMS AND RELATED MATTERS Training § 1960.54 Training of top management officials. Each agency shall provide top management officials with orientation and other learning experiences which will enable them...

  17. 49 CFR 229.71 - Clearance above top of rail.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Clearance above top of rail. 229.71 Section 229.71....71 Clearance above top of rail. No part or appliance of a locomotive except the wheels, flexible nonmetallic sand pipe extension tips, and trip cock arms may be less than 21/2 inches above the top of rail....

  18. 77 FR 66182 - Race to the Top-District

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-02

    ... Register (77 FR 49654) a notice inviting applications for the Race to the Top--District competition. That... to the Top--District AGENCY: Office of the Deputy Secretary, Department of Education. ACTION: Notice reopening the Race to the Top--District competition. Catalog of Federal Domestic Assistance (CFDA)...

  19. 29 CFR 1960.54 - Training of top management officials.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 9 2014-07-01 2014-07-01 false Training of top management officials. 1960.54 Section 1960... PROGRAMS AND RELATED MATTERS Training § 1960.54 Training of top management officials. Each agency shall provide top management officials with orientation and other learning experiences which will enable them...

  20. 49 CFR 229.71 - Clearance above top of rail.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Clearance above top of rail. 229.71 Section 229.71....71 Clearance above top of rail. No part or appliance of a locomotive except the wheels, flexible nonmetallic sand pipe extension tips, and trip cock arms may be less than 21/2 inches above the top of rail....

  1. Using Desk-Top Publishing to Develop Literacy.

    ERIC Educational Resources Information Center

    Wray, David; Medwell, Jane

    1989-01-01

    Examines the learning benefits which may accrue from using desk-top publishing techniques with children, especially in terms of the development of literacy skills. Analyzes desk-top publishing as an extension of word processing and describes some ways of using desk-top publishing in the classroom. (RS)

  2. Top Contributors to the School Psychology Literature: 1996-2005

    ERIC Educational Resources Information Center

    Roberts, Gabrielle A.; Davis, Kim S.; Zanger, Dinorah; Gerrard-Morris, Aimee; Robinson, Daniel H.

    2006-01-01

    S.G. Little (1997) reported the top contributors to the school psychology literature from 1987 to 1995. The present study represents a follow-up by examining the top contributors from 1996 to 2005. Similar to Little, a list of the top 50 contributors was developed using a point system that assigned more credit based on fewer coauthors and higher…

  3. Control in Highly Focused Top-Spinning. Brief Report.

    ERIC Educational Resources Information Center

    Berkson, Gershon

    1998-01-01

    Three studies analyzed stimulus feedback and the concept of control with three children and two adults having autism. The first study explored feedback from spinning tops, while the second and third emphasized control of various stimuli including spinning tops. Results indicate that autistic individuals' common interest in spinning tops is…

  4. Collider Detector at Fermilab (CDF): Data from the Top Group's Top Quark Research

    DOE Data Explorer

    The Collider Detector at Fermilab (CDF) is a Tevatron experiment at Fermilab. The Tevatron, a powerful particle accelerator, accelerates protons and antiprotons close to the speed of light, and then makes them collide head-on inside the CDF detector. The CDF detector is used to study the products of such collisions. The CDF Physics Group at Fermilab is organized into six working groups, each with a specific focus. The Top group studies the properties of the top quark, the heaviest known fundamental particle. Their public web page makes data and numerous figures available from both CDF Runs I and II.

  5. Some new results on three-dimensional rotations and pseudo-rotations

    NASA Astrophysics Data System (ADS)

    Brezov, D. S.; Mladenova, C. D.; Mladenov, Ivaïlo M.

    2013-10-01

    We use a vector parameter technique to obtain the generalized Euler decompositions with respect to arbitrarily chosen axes for the three-dimensional special orthogonal group SO(3) and the three-dimensional Lorentz group SO(2;1). Our approach, based on projecting a quaternion (respectively split quaternion) from the corresponding spin cover, has proven quite effective in various problems of geometry and physics [1, 2, 3]. In particular, we obtain explicit (generally double-valued) expressions for the three parameters in the decomposition and discuss separately the degenerate and divergent solutions, as well as decompositions with respect to two axes. There are some straightforward applications of this method in special relativity and quantum mechanics which are discussed elsewhere (see [4]).

  6. Variations of (pseudo-)rotations and the Laplace-Beltrami operator on homogeneous spaces

    SciTech Connect

    Brezov, D. S.; Mladenova, C. D.; Mladenov, I. M.

    2015-10-28

    In this paper we obtain the Lie derivatives of the scalar parameters in the generalized Euler decomposition with respect to arbitrary axes under left and right deck transformations. This problem can be directly related to the representation of the angular momentum in quantum mechanics. As a particular example, we calculate the angular momentum and the corresponding quantum hamiltonian in the standard Euler and Bryan representations. Similarly, in the hyperbolic case, the Laplace-Beltrami operator is retrieved for the Iwasawa decomposition. The case of two axes is considered as well.

  7. Top marine predators track Lagrangian coherent structures

    PubMed Central

    Tew Kai, Emilie; Rossi, Vincent; Sudre, Joel; Weimerskirch, Henri; Lopez, Cristobal; Hernandez-Garcia, Emilio; Marsac, Francis; Garçon, Veronique

    2009-01-01

    Meso- and submesoscales (fronts, eddies, filaments) in surface ocean flow have a crucial influence on marine ecosystems. Their dynamics partly control the foraging behavior and the displacement of marine top predators (tuna, birds, turtles, and cetaceans). In this work we focus on the role of submesoscale structures in the Mozambique Channel in the distribution of a marine predator, the Great Frigatebird. Using a newly developed dynamic concept, the finite-size Lyapunov exponent (FSLE), we identified Lagrangian coherent structures (LCSs) present in the surface flow in the channel over a 2-month observation period (August and September 2003). By comparing seabird satellite positions with LCS locations, we demonstrate that frigatebirds track precisely these structures in the Mozambique Channel, providing the first evidence that a top predator is able to track these FSLE ridges to locate food patches. After comparing bird positions during long and short trips and different parts of these trips, we propose several hypotheses to understand how frigatebirds can follow these LCSs. The birds might use visual and/or olfactory cues and/or atmospheric current changes over the structures to move along these biologic corridors. The birds being often associated with tuna schools around foraging areas, a thorough comprehension of their foraging behavior and movement during the breeding season is crucial not only to seabird ecology but also to an appropriate ecosystemic approach to fisheries in the channel. PMID:19416811

  8. Measurement of the top quark mass

    SciTech Connect

    Varnes, E.W.

    1997-12-31

    This dissertation describes the measurement of the top quark mass m{sub t} using events recorded during a 125 pb{sup -1} exposure of the D0 detector to {radical}s=1.8 TeV {anti p}p collisions. Six events consistent with the hypothesis t{anti t} {yields} bW{sup +}, {anti b}W{sup -} {yields} b{anti l}{nu}, {anti b}l{anti {nu}} form the dilepton sample. The kinematics of such events may be reconstructed for any assumed mt, and the likelihood of each such solution evaluated. A measurement of m{sub t} based on these relative solution likelihoods gives m{sub t} = 169.9 {+-} 14.8 (stat.) {+-} 3. 8 (syst.) GeV/c{sup 2}. A 2C kinematic fit is performed on a sample of 77 events consistent with t{anti t} {yields} bW{sup +}, {anti b}W{sup -} {yields} b{anti l}{nu}, {anti b}q{anti q} , and this, in combination with an estimate on the likelihood that each event is top, yields m{sub t} = 173.3 {+-} 5.6 (stat.) {+-} 6.2 (syst.) GeV/c{sup 2} . A combination of these two measurements gives m{sub t} = 173.1 {+-} 5.2 (stat.) {+-} 5.7 (syst.) GeV/c{sup 2}.

  9. Top marine predators track Lagrangian coherent structures.

    PubMed

    Tew Kai, Emilie; Rossi, Vincent; Sudre, Joel; Weimerskirch, Henri; Lopez, Cristobal; Hernandez-Garcia, Emilio; Marsac, Francis; Garçon, Veronique

    2009-05-19

    Meso- and submesoscales (fronts, eddies, filaments) in surface ocean flow have a crucial influence on marine ecosystems. Their dynamics partly control the foraging behavior and the displacement of marine top predators (tuna, birds, turtles, and cetaceans). In this work we focus on the role of submesoscale structures in the Mozambique Channel in the distribution of a marine predator, the Great Frigatebird. Using a newly developed dynamic concept, the finite-size Lyapunov exponent (FSLE), we identified Lagrangian coherent structures (LCSs) present in the surface flow in the channel over a 2-month observation period (August and September 2003). By comparing seabird satellite positions with LCS locations, we demonstrate that frigatebirds track precisely these structures in the Mozambique Channel, providing the first evidence that a top predator is able to track these FSLE ridges to locate food patches. After comparing bird positions during long and short trips and different parts of these trips, we propose several hypotheses to understand how frigatebirds can follow these LCSs. The birds might use visual and/or olfactory cues and/or atmospheric current changes over the structures to move along these biologic corridors. The birds being often associated with tuna schools around foraging areas, a thorough comprehension of their foraging behavior and movement during the breeding season is crucial not only to seabird ecology but also to an appropriate ecosystemic approach to fisheries in the channel. PMID:19416811

  10. [The "top ten" of Finnish medicine].

    PubMed

    Leikola, A

    1998-01-01

    In the early 1980s the Wellcome Institute was planning a biographical dictionary on the world's most eminent physicians. The quota reserved for Finland was ten names, and having been asked by Dr. Karin Johannisson, Uppsala, to participate in the project, I undertook the task of choosing them and providing a short biography of each. For this, I asked the advice of ten experts on the history of Finnish medicine, and a "top ten" list was then compiled. The list extended from Johan Haartman, "the father of Finnish medicine", till the Nobel Prize winner Ragnar Granit and the famous pediatrist Arvo Ylppo, who were still alive in the 1980s. The biographies were sent to the editor of the dictionary, but it seems that the work was never published. As I had saved all my correspondence about the matter, it seemed now, fifteen years afterwards, interesting to publish a short report of the project, including an account of how the "top ten" list had been achieved. PMID:11625413

  11. Spin-one top partner: phenomenology

    NASA Astrophysics Data System (ADS)

    Collins, Jack H.; Jain, Bithika; Perelstein, Maxim; Lorier, Nicolas Rey-Le

    2014-08-01

    Cai, Cheng, and Terning (CCT) suggested a model in which the left-handed top quark is identified with a gaugino of an extended gauge group, and its superpartner is a spin-1 particle. We perform a phenomenological analysis of this model, with a focus on the spin-1 top partner, which we dub the "swan". We find that precision electroweak fits, together with direct searches for Z ' bosons at the LHC, place a lower bound of at least about 4.5 TeV on the swan mass. An even stronger bound, 10 TeV or above, applies in most of the parameter space, mainly due to the fact that the swan is typically predicted to be significantly heavier than the Z '. We find that the 125 GeV Higgs can be easily accommodated in this model with non-decoupling D-terms. In spite of the strong lower bound on the swan mass, we find that corrections to Higgs couplings to photons and gluons induced by swan loops are potentially observable at future Higgs factories. We also briefly discuss the prospects for discovering a swan at the proposed 100 TeV pp collider.

  12. Artificial Molecular Machines.

    PubMed

    Balzani; Credi; Raymo; Stoddart

    2000-10-01

    The miniaturization of components used in the construction of working devices is being pursued currently by the large-downward (top-down) fabrication. This approach, however, which obliges solid-state physicists and electronic engineers to manipulate progressively smaller and smaller pieces of matter, has its intrinsic limitations. An alternative approach is a small-upward (bottom-up) one, starting from the smallest compositions of matter that have distinct shapes and unique properties-namely molecules. In the context of this particular challenge, chemists have been extending the concept of a macroscopic machine to the molecular level. A molecular-level machine can be defined as an assembly of a distinct number of molecular components that are designed to perform machinelike movements (output) as a result of an appropriate external stimulation (input). In common with their macroscopic counterparts, a molecular machine is characterized by 1) the kind of energy input supplied to make it work, 2) the nature of the movements of its component parts, 3) the way in which its operation can be monitored and controlled, 4) the ability to make it repeat its operation in a cyclic fashion, 5) the timescale needed to complete a full cycle of movements, and 6) the purpose of its operation. Undoubtedly, the best energy inputs to make molecular machines work are photons or electrons. Indeed, with appropriately chosen photochemically and electrochemically driven reactions, it is possible to design and synthesize molecular machines that do work. Moreover, the dramatic increase in our fundamental understanding of self-assembly and self-organizational processes in chemical synthesis has aided and abetted the construction of artificial molecular machines through the development of new methods of noncovalent synthesis and the emergence of supramolecular assistance to covalent synthesis as a uniquely powerful synthetic tool. The aim of this review is to present a unified view of the field

  13. Top-Down, Intelligent Reservoir Model

    NASA Astrophysics Data System (ADS)

    Mohaghegh, Shahab

    2010-05-01

    Conventional reservoir simulation and modeling is a bottom-up approach. It starts with building a geological model of the reservoir that is populated with the best available petrophysical and geophysical information at the time of development. Engineering fluid flow principles are added and solved numerically so as to arrive at a dynamic reservoir model. The dynamic reservoir model is calibrated using the production history of multiple wells and the history matched model is used to strategize field development in order to improve recovery. Top-Down, Intelligent Reservoir Modeling approaches the reservoir simulation and modeling from an opposite angle by attempting to build a realization of the reservoir starting with the measured well production behavior (history). The production history is augmented by core, log, well test and seismic data in order to increase the accuracy of the Top-Down modeling technique. Although not intended as a substitute for the conventional reservoir simulation of large, complex fields, this novel approach to reservoir modeling can be used as an alternative (at a fraction of the cost) to conventional reservoir simulation and modeling in cases where performing conventional modeling is cost (and man-power) prohibitive. In cases where a conventional model of a reservoir already exists, Top-Down modeling should be considered as a compliment to, rather than a competition for the conventional technique, to provide an independent look at the data coming from the reservoir/wells for optimum development strategy and recovery enhancement. Top-Down, Intelligent Reservoir Modeling starts with well-known reservoir engineering techniques such as Decline Curve Analysis, Type Curve Matching, History Matching using single well numerical reservoir simulation, Volumetric Reserve Estimation and calculation of Recovery Factors for all the wells (individually) in the field. Using statistical techniques multiple Production Indicators (3, 6, and 9 months cum

  14. The analysis of the market success of FDA approvals by probing top 100 bestselling drugs.

    PubMed

    Polanski, Jaroslaw; Bogocz, Jacek; Tkocz, Aleksandra

    2016-05-01

    Target-oriented drug discovery is the main research paradigm of contemporary drug discovery. In target-oriented approaches, we attempt to maximize in vitro drug potency by finding the optimal fit to the target. This can result in a higher molecular complexity, in particular, the higher molecular weight (MW) of the drugs. However, a comparison of the successful developments of pharmaceuticals with the general trends that can be observed in medicinal chemistry resulted in the conclusion that the so-called molecular obesity is an important reason for the attrition rate of drugs. When analyzing the list of top 100 drug bestsellers versus all of the FDA approvals, we discovered that on average lower-complexity (MW, ADMET score) drugs are winners of the top 100 list in terms of numbers but that, especially, up to some optimal MW value, a higher molecular complexity can pay off with higher incomes. This indicates that slim drugs are doing better but that fat drugs are bigger fishes to catch. PMID:27125384

  15. Top 10% Admissions in the Borderlands: Access and Success of Borderland Top Students at Texas Public Universities

    ERIC Educational Resources Information Center

    Rodríguez, Cristóbal

    2016-01-01

    This study focuses on Texas Borderland students admitted through the Texas Top 10% admissions policy, which assumes that Top 10% students are college ready for any public university and provides Top 10% high school graduates automatic admission to any 4-year public university in Texas. Using descriptive and inferential statistics, results…

  16. Molecular dynamics

    SciTech Connect

    Ladd, A.J.C.

    1988-08-01

    The basic methodology of equilibrium molecular dynamics is described. Examples from the literature are used to illustrate how molecular dynamics has been used to resolve theoretical controversies, provide data to test theories, and occasionally to discover new phenomena. The emphasis is on the application of molecular dynamics to an understanding of the microscopic physics underlying the transport properties of simple fluids. 98 refs., 4 figs.

  17. Searches for New Physics in Top Decays at D0

    SciTech Connect

    Pleier, Marc-Andre; /Brookhaven

    2011-08-01

    The Tevatron proton-antiproton collider at Fermilab with its centre of mass energy of 1.96 TeV allows for pair production of top quarks and the study of top quark decay properties. This report reflects the current status of measurements of the W boson helicity in top quark decays and the ratio of top quark branching fractions as well as searches for neutral current top quark decays and pair production of fourth generation t' quarks, performed by the D0 Collaboration utilising datasets of up to 5.4 fb{sup -1}.

  18. Summary of Single top quark production at the Tevatron

    SciTech Connect

    Schwienhorst, R.; CDF, on the

    2014-01-01

    The production of single-top quarks occurs via the weak interaction at the Fermilab Tevatron proton-antiproton collider. Single top quark events are selected in the lepton+jets final state by CDF and D0 and in the missing transverse energy plus jets final state by CDF. Multivariate classifiers separate the s-channel and t-channel single-top signals from the large backgrounds. The combination of CDF and D0 results leads to the first observation of the s-channel mode of single top quark production. The t-channel and single top combined cross sections have also been measured.

  19. Alignment of asymmetric-top molecules using multiple-pulse trains

    SciTech Connect

    Pabst, Stefan; Santra, Robin

    2010-06-15

    We theoretically analyze the effectiveness of multiple-pulse laser alignment methods for asymmetric-top molecules. As an example, we choose SO{sub 2} and investigate the alignment dynamics induced by two different sequences, each consisting of four identical laser pulses. Each sequence differs only in the time delay between the pulses. Equally spaced pulses matching the alignment revival of the symmetrized SO{sub 2} rotor model are exploited in the first sequence. The pulse separations in the second sequence are short compared to the rotation dynamics of the molecule and monotonically increase the degree of alignment until the maximum alignment is reached. We point out the significant differences between the alignment dynamics of SO{sub 2} treated as an asymmetric-top and a symmetric-top rotor, respectively. We also explain why the fast sequence of laser pulses creates considerably stronger one-dimensional molecular alignment for asymmetric-top molecules. In addition, we show that multiple-pulse trains with elliptically polarized pulses do not enhance one-dimensional alignment or create three-dimensional alignment.

  20. Alignment of asymetric-top molecules using multiple-pulse trains.

    SciTech Connect

    Pabst, S.; Santra, R.; X-Ray Science Division; Univ. Erlangen-Nuremberg; Univ. of Chicago

    2010-06-07

    We theoretically analyze the effectiveness of multiple-pulse laser alignment methods for asymmetric-top molecules. As an example, we choose SO2 and investigate the alignment dynamics induced by two different sequences, each consisting of four identical laser pulses. Each sequence differs only in the time delay between the pulses. Equally spaced pulses matching the alignment revival of the symmetrized SO2 rotor model are exploited in the first sequence. The pulse separations in the second sequence are short compared to the rotation dynamics of the molecule and monotonically increase the degree of alignment until the maximum alignment is reached. We point out the significant differences between the alignment dynamics of SO2 treated as an asymmetric-top and a symmetric-top rotor, respectively. We also explain why the fast sequence of laser pulses creates considerably stronger one-dimensional molecular alignment for asymmetric-top molecules. In addition, we show that multiple-pulse trains with elliptically polarized pulses do not enhance one-dimensional alignment or create three-dimensional alignment.

  1. Top Down Proteomics Reveals Mature Proteoforms Expressed in Subcellular Fractions of the Echinococcus granulosus Preadult Stage.

    PubMed

    Lorenzatto, Karina R; Kim, Kyunggon; Ntai, Ioanna; Paludo, Gabriela P; Camargo de Lima, Jeferson; Thomas, Paul M; Kelleher, Neil L; Ferreira, Henrique B

    2015-11-01

    Echinococcus granulosus is the causative agent of cystic hydatid disease, a neglected zoonosis responsible for high morbidity and mortality. Several molecular mechanisms underlying parasite biology remain poorly understood. Here, E. granulosus subcellular fractions were analyzed by top down and bottom up proteomics for protein identification and characterization of co-translational and post-translational modifications (CTMs and PTMs, respectively). Nuclear and cytosolic extracts of E. granulosus protoscoleces were fractionated by 10% GELFrEE and proteins under 30 kDa were analyzed by LC-MS/MS. By top down analysis, 186 proteins and 207 proteoforms were identified, of which 122 and 52 proteoforms were exclusively detected in nuclear and cytosolic fractions, respectively. CTMs were evident as 71% of the proteoforms had methionine excised and 47% were N-terminal acetylated. In addition, in silico internal acetylation prediction coupled with top down MS allowed the characterization of 9 proteins differentially acetylated, including histones. Bottom up analysis increased the overall number of identified proteins in nuclear and cytosolic fractions to 154 and 112, respectively. Overall, our results provided the first description of the low mass proteome of E. granulosus subcellular fractions and highlighted proteoforms with CTMs and PTMS whose characterization may lead to another level of understanding about molecular mechanisms controlling parasitic flatworm biology. PMID:26465659

  2. Environmental assessment of curly top virus control in California. [Curly Top Virus

    SciTech Connect

    Not Available

    1991-03-15

    Curly top is a viral disease of sugarbeets, tomatoes, melons, peppers, beans, cucumbers, squash, pumpkins, spinach, vineseed and other commercially important crops, including ornamentals. Curly top not only infects commercial crops, but at times devastates backyard vegetable and flower gardens. The only known vector of curly top is Circulifer tenellus, commonly known as the beet leafhopper. Control of the beet leafhopper may take place at various locations throughout the San Joaquin Valley, Salinas Valley, Cuyama Valley, Antelope Valley of northern Los Angeles County, Riverside County and the Imperial Valley (See Maps in Appendix E''), including portions of Merced, Fresno, Kings. Kern, San Luis Obispo, Monterey, San Benito, Santa Barbara, Los Angeles, Riverside and Imperial Counties. The size of the control program is totally dependent on the location, size, nd distribution of the beet leafhopper population. In a year with a low population, only 80,000 acres in western Fresno, Kings, and Kern Counties may require treatment. In a drought year, the treatment required may increase to more than 200,000 acres and include some inter-coastal valleys of Monterey, San Luis Obispo and Santa Barbara Counties. Not all areas require treatment on an annual basis and at no time is the entire area subject to blanket treatment. The Curly Top Virus Control Program (CTVCP) was instrumental in supporting research which developed an antisera allowing the use of Enzyme-Linked Immunosorbent Assay to determine the presence, on a percentage basis, of curly top virus. Thus, the amount of virus found in a given area lends weight to treatment priorities.

  3. Top Quarks and the High Energy Frontier

    NASA Astrophysics Data System (ADS)

    Canelli, Florencia

    2006-04-01

    One of the still missing pieces of the Standard Model of particle physics is the Higgs boson, providing a mechanism to generate the masses of the particles. Furthermore, there is strong indication that the Standard Model is merely the low energy limit of a more fundamental theory which could manifest itself near the TeV scale. This talk will explore aspects of experimentation at the High Energy frontier, starting from experience at the Tevatron accelerator currently providing the world's highest energy particle collisions. In particular, a precision measurement of the top quark mass using the Collider Detector at Fermilab (CDF) will be presented. An outlook will be given towards a direct search for the Higgs boson and New Physics at the LHC and beyond, concluding with a historic perspective.

  4. Top partners searches and composite Higgs models

    NASA Astrophysics Data System (ADS)

    Matsedonskyi, Oleksii; Panico, Giuliano; Wulzer, Andrea

    2016-04-01

    Colored fermionic partners of the top quark are well-known signatures of the Composite Higgs scenario and for this reason they have been and will be subject of an intensive experimental study at the LHC. Performing an assessment of the theoretical implications of this experimental effort is the goal of the present paper. We proceed by analyzing a set of simple benchmark models, characterized by simple two-dimensional parameter spaces where the results of the searches are conveniently visualized and their impact quantified. We only draw exclusion contours, in the hypothesis of no signal, but of course our formalism could equally well be used to report discoveries in a theoretically useful format.

  5. The Great White Guppy: Top Predator

    NASA Astrophysics Data System (ADS)

    Michalski, G. M.

    2011-12-01

    Nitrogen isotopes are often used to trace the trophic level of members of an ecosystem. As part of a stable isotope biogeochemistry and forensics course at Purdue University, students are introduced to this concept by analyzing nitrogen isotopes in sea food purchased from local grocery stores. There is a systematic increase in 15N/14N ratios going from kelp to clams/shrimp, to sardines, to tuna and finally to shark. These enrichments demonstrate how nitrogen is enriched in biomass as predators consume prey. Some of the highest nitrogen isotope enrichments observed, however, are in the common guppy. We investigated a number of aquarium fish foods and find they typically have high nitrogen isotope ratios because they are made form fish meal that is produced primarily from the remains of predator fish such as tuna. From, a isotope perspective, the guppy is the top of the food chain, more ferocious than even the Great White shark.

  6. Observation of single top at CDF

    SciTech Connect

    Casal, Bruno; /Cantabria Inst. of Phys.

    2009-01-01

    We present observation of electroweak single top quark production using 3.2 fb{sup -1} of data collected by the CDF experiment. Candidate events are selected for further classification by five parallel analysis techniques: one using a likelihood discriminant, one using a matrix-element discriminant, one using decision trees, one using a neural network, and one using a complementary dataset. The results of these analyses are combined in order to improve the expected sensitivity. The significance of the observed data is 5.0 standard deviations, and the expected sensitivity is in excess of 5.9 standard deviations. We also present the most current value of the CKM matrix element |V{sub tb}|.

  7. Who rises to the top? Early indicators.

    PubMed

    Kell, Harrison J; Lubinski, David; Benbow, Camilla P

    2013-05-01

    Youth identified before age 13 (N = 320) as having profound mathematical or verbal reasoning abilities (top 1 in 10,000) were tracked for nearly three decades. Their awards and creative accomplishments by age 38, in combination with specific details about their occupational responsibilities, illuminate the magnitude of their contribution and professional stature. Many have been entrusted with obligations and resources for making critical decisions about individual and organizational well-being. Their leadership positions in business, health care, law, the professoriate, and STEM (science, technology, engineering, and mathematics) suggest that many are outstanding creators of modern culture, constituting a precious human-capital resource. Identifying truly profound human potential, and forecasting differential development within such populations, requires assessing multiple cognitive abilities and using atypical measurement procedures. This study illustrates how ultimate criteria may be aggregated and longitudinally sequenced to validate such measures. PMID:23531483

  8. System availability top-down apportionment method

    SciTech Connect

    Haire, M.J.; Maltese, J.G.; Sohmer, R.G.

    1985-01-01

    A top-down method for apportioning overall manufacturing facility availability among systems and subsystems is presented. Characteristics which influence equipment reliability are defined. Experts, using engineering judgement, score each characteristic for each equipment system whose availability design goal is to be established. Scores for each characteristic are combined into weighting factors. A mathematical model is derived which incorporates these weighting factors. This methodology establishes tradeoffs among facility systems: the method imposes high-availability requirements on those systems in which an incremental increase in availability is easier to attain, and lower requirements on those in which an increase in availability is more difficult and costly. An example application of the method is presented.

  9. Identification of Leishmania donovani Topoisomerase 1 inhibitors via intuitive scaffold hopping and bioisosteric modification of known Top 1 inhibitors

    NASA Astrophysics Data System (ADS)

    Mamidala, Rajinikanth; Majumdar, Papiya; Jha, Kunal Kumar; Bathula, Chandramohan; Agarwal, Rahul; Chary, M. Thirumala; Mazumdar, H. K.; Munshi, Parthapratim; Sen, Subhabrata

    2016-05-01

    A library of arylidenefuropyridinediones was discovered as potent inhibitors of Leishmania donovani Topoisomerase 1 (LdTop1) where the active molecules displayed considerable inhibition with single digit micromolar EC50 values. This molecular library was designed via intuitive scaffold hopping and bioisosteric modification of known topoisomerase 1 inhibitors such as camptothecin, edotecarin and etc. The design was rationalized by molecular docking analysis of the compound prototype with human topoisomerase 1 (HTop1) and Leishmania donovani topoisomerase 1(LdTop1). The most active compound 4 displayed no cytotoxicity against normal mammalian COS7 cell line (~100 fold less inhibition at the EC50). Similar to camptothecin, 4 interacted with free LdTop1 as observed in the preincubation DNA relaxation inhibition experiment. It also displayed anti-protozoal activity against Leishmania donovani promastigote. Crystal structure investigation of 4 and its molecular modelling with LdTop1 revealed putative binding sites in the enzyme that could be harnessed to generate molecules with better potency.

  10. Identification of Leishmania donovani Topoisomerase 1 inhibitors via intuitive scaffold hopping and bioisosteric modification of known Top 1 inhibitors

    PubMed Central

    Mamidala, Rajinikanth; Majumdar, Papiya; Jha, Kunal Kumar; Bathula, Chandramohan; Agarwal, Rahul; Chary, M. Thirumala; Mazumdar, H. K.; Munshi, Parthapratim; Sen, Subhabrata

    2016-01-01

    A library of arylidenefuropyridinediones was discovered as potent inhibitors of Leishmania donovani Topoisomerase 1 (LdTop1) where the active molecules displayed considerable inhibition with single digit micromolar EC50 values. This molecular library was designed via intuitive scaffold hopping and bioisosteric modification of known topoisomerase 1 inhibitors such as camptothecin, edotecarin and etc. The design was rationalized by molecular docking analysis of the compound prototype with human topoisomerase 1 (HTop1) and Leishmania donovani topoisomerase 1(LdTop1). The most active compound 4 displayed no cytotoxicity against normal mammalian COS7 cell line (~100 fold less inhibition at the EC50). Similar to camptothecin, 4 interacted with free LdTop1 as observed in the preincubation DNA relaxation inhibition experiment. It also displayed anti-protozoal activity against Leishmania donovani promastigote. Crystal structure investigation of 4 and its molecular modelling with LdTop1 revealed putative binding sites in the enzyme that could be harnessed to generate molecules with better potency. PMID:27221589

  11. Identification of Leishmania donovani Topoisomerase 1 inhibitors via intuitive scaffold hopping and bioisosteric modification of known Top 1 inhibitors.

    PubMed

    Mamidala, Rajinikanth; Majumdar, Papiya; Jha, Kunal Kumar; Bathula, Chandramohan; Agarwal, Rahul; Chary, M Thirumala; Mazumdar, H K; Munshi, Parthapratim; Sen, Subhabrata

    2016-01-01

    A library of arylidenefuropyridinediones was discovered as potent inhibitors of Leishmania donovani Topoisomerase 1 (LdTop1) where the active molecules displayed considerable inhibition with single digit micromolar EC50 values. This molecular library was designed via intuitive scaffold hopping and bioisosteric modification of known topoisomerase 1 inhibitors such as camptothecin, edotecarin and etc. The design was rationalized by molecular docking analysis of the compound prototype with human topoisomerase 1 (HTop1) and Leishmania donovani topoisomerase 1(LdTop1). The most active compound 4 displayed no cytotoxicity against normal mammalian COS7 cell line (~100 fold less inhibition at the EC50). Similar to camptothecin, 4 interacted with free LdTop1 as observed in the preincubation DNA relaxation inhibition experiment. It also displayed anti-protozoal activity against Leishmania donovani promastigote. Crystal structure investigation of 4 and its molecular modelling with LdTop1 revealed putative binding sites in the enzyme that could be harnessed to generate molecules with better potency. PMID:27221589

  12. Jet Dipolarity: Top Tagging with Color Flow

    SciTech Connect

    Hook, Anson; Jankowiak, Martin; Wacker, Jay G.; /SLAC

    2011-08-12

    A new jet observable, dipolarity, is introduced that can distinguish whether a pair of subjets arises from a color singlet source. This observable is incorporated into the HEPTopTagger and is shown to improve discrimination between top jets and QCD jets for moderate to high p{sub T}. The impressive resolution of the ATLAS and CMS detectors means that a typical QCD jet at the LHC deposits energy in {Omicron}(10-100) calorimeter cells. Such fine-grained calorimetry allows for jets to be studied in much greater detail than previously, with sophisticated versions of current techniques making it possible to measure more than just the bulk properties of jets (e.g. event jet multiplicities or jet masses). One goal of the LHC is to employ these techniques to extend the amount of information available from each jet, allowing for a broader probe of the properties of QCD. The past several years have seen significant progress in developing such jet substructure techniques. A number of general purpose tools have been developed, including: (i) top-tagging algorithms designed for use at both lower and higher p{sub T} as well as (ii) jet grooming techniques such as filtering, pruning, and trimming, which are designed to improve jet mass resolution. Jet substructure techniques have also been studied in the context of specific particle searches, where they have been shown to substantially extend the reach of traditional search techniques in a wide variety of scenarios, including for example boosted Higgses, neutral spin-one resonances, searches for supersymmetry, and many others. Despite these many successes, however, there is every reason to expect that there remains room for refinement of jet substructure techniques.

  13. Molecular motors

    NASA Astrophysics Data System (ADS)

    Allemand, Jean François Desbiolles, Pierre

    2015-10-01

    How do we move? More precisely, what are the molecular mechanisms that can explain that our muscles, made of very small components can move at a osopic scale? To answer these questions we must introduce molecular motors. Those motors are proteins, or small protein assemblies that, in our cells, transform chemical energy into mechanical work. Then, like we could do for a oscopic motor, used in a car or in a fan, we are going to study the basic behavior of these molecular machines, present what are their energy sources, calculate their power, their yield. If molecular motors are crucial for our oscopic movements, we are going to see that they are also essential to cellular transport and that considering the activity of some enzymes as molecular motors bring some interesting new insights on their activity.

  14. GGsTOP increases migration of human periodontal ligament cells in vitro via reactive oxygen species pathway.

    PubMed

    Jiang, Ying; Wang, Xiang; Li, Ying; Mu, Sen; Zhou, Shuang; Liu, Yi; Zhang, Bin

    2016-05-01

    GGsTOP is a novel and selective inhibitor of gamma-glutamyl transferase (GGT), a cell-surface enzyme that has a key role in glutathione homeostasis and the maintenance of cellular reactive oxygen species (ROS). ROS are essential for wound healing. However, little is known about the molecular mechanisms underlying the inhibition of GGT by GGsTOP in human periodontal ligament cells (hPLCs). The present study assessed GGT expression in mouse periodontal ligament tissues, GGT activity in hPLCs, and the potential physiological effect of GGsTOP on hPLC migration. Immunohistochemical analysis confirmed that GGT was widely expressed in mouse periodontal ligament tissue. Treatment with GGsTOP was associated with greater proliferation and migration of hPLCs, and higher levels of cellular ROS compared with untreated hPLCs. However, the increase in intracellular ROS was attenuated in hPLCs co‑cultured with the anti‑oxidant N‑acetylcysteine (NAC), a precursor of glutathione. The higher ROS levels associated with GGsTOP treatment were in parallel with increases in the levels of type I collagen and alpha smooth muscle actin, which was inhibited in hPLCs co‑cultured with NAC. Thus, GGsTOP may promote hPLC migration and participate in the maintenance of the periodontal ligament apparatus via the ROS pathway. PMID:27035100

  15. GGsTOP increases migration of human periodontal ligament cells in vitro via reactive oxygen species pathway

    PubMed Central

    JIANG, YING; WANG, XIANG; LI, YING; MU, SEN; ZHOU, SHUANG; LIU, YI; ZHANG, BIN

    2016-01-01

    GGsTOP is a novel and selective inhibitor of gamma-glutamyl transferase (GGT), a cell-surface enzyme that has a key role in glutathione homeostasis and the maintenance of cellular reactive oxygen species (ROS). ROS are essential for wound healing. However, little is known about the molecular mechanisms underlying the inhibition of GGT by GGsTOP in human periodontal ligament cells (hPLCs). The present study assessed GGT expression in mouse periodontal ligament tissues, GGT activity in hPLCs, and the potential physiological effect of GGsTOP on hPLC migration. Immunohistochemical analysis confirmed that GGT was widely expressed in mouse periodontal ligament tissue. Treatment with GGsTOP was associated with greater proliferation and migration of hPLCs, and higher levels of cellular ROS compared with untreated hPLCs. However, the increase in intracellular ROS was attenuated in hPLCs co-cultured with the anti-oxidant N-acetylcysteine (NAC), a precursor of glutathione. The higher ROS levels associated with GGsTOP treatment were in parallel with increases in the levels of type I collagen and alpha smooth muscle actin, which was inhibited in hPLCs co-cultured with NAC. Thus, GGsTOP may promote hPLC migration and participate in the maintenance of the periodontal ligament apparatus via the ROS pathway. PMID:27035100

  16. Top-down causation and emergence: some comments on mechanisms

    PubMed Central

    Ellis, George F. R.

    2012-01-01

    Both bottom-up and top-down causation occur in the hierarchy of structure and causation. A key feature is multiple realizability of higher level functions, and consequent existence of equivalence classes of lower level variables that correspond to the same higher level state. Five essentially different classes of top-down influence can be identified, and their existence demonstrated by many real-world examples. They are: algorithmic top-down causation; top-down causation via non-adaptive information control, top-down causation via adaptive selection, top-down causation via adaptive information control and intelligent top-down causation (the effect of the human mind on the physical world). Through the mind, abstract entities such as mathematical structures have causal power. The causal slack enabling top-down action to take place lies in the structuring of the system so as to attain higher level functions; in the way the nature of lower level elements is changed by context, and in micro-indeterminism combined with adaptive selection. Understanding top-down causation can have important effects on society. Two cases will be mentioned: medical/healthcare issues, and education—in particular, teaching reading and writing. In both cases, an ongoing battle between bottom-up and top-down approaches has important consequences for society. PMID:23386967

  17. Complex decay chains of top and bottom squarks

    NASA Astrophysics Data System (ADS)

    Eckel, Jonathan; Su, Shufang; Zhang, Huanian

    2015-07-01

    Current searches for the top squark mostly focus on the decay channels of or , leading to tt/bbWW + [InlineMediaObject not available: see fulltext.] final states for top squark pair production at the LHC. In supersymmetric scenarios with light gauginos other than the neutralino lightest supersymmetric particle (LSP), different decay modes of the top squark could be dominant, which significantly weaken the current top squark search limits at the LHC. Additionally, new decay modes offer alternative discovery channels for top squark searches. In this paper, we study the top squark and bottom squark decay in the Bino-like LSP case with light Wino or Higgsino next-to-LSPs (NLSPs), and identify cases in which additional decay modes become dominant. We also perform a collider analysis for top squark pair production with mixed top squark decay final states of , leading to the bbbbjjℓ + [InlineMediaObject not available: see fulltext.] collider signature. The branching fraction for such decay varies between 25% and 50% for a top squark mass larger than 500 GeV with M 2 = M 1 + 150 GeV. At the 14 TeV LHC with 300 fb-1 integrated luminosity, the top squark can be excluded up to about 1040 GeV at the 95% C.L., or be discovered up to 940 GeV at 5 σ significance.

  18. Adiabatic Field-Free Alignment of Asymmetric Top Molecules with an Optical Centrifuge.

    PubMed

    Korobenko, A; Milner, V

    2016-05-01

    We use an optical centrifuge to align asymmetric top SO_{2} molecules by adiabatically spinning their most polarizable O-O axis. The effective centrifugal potential in the rotating frame confines the sulfur atoms to the plane of the laser-induced rotation, leading to the planar molecular alignment that persists after the molecules are released from the centrifuge. The periodic appearance of the full three-dimensional alignment, typically observed only with linear and symmetric top molecules, is also detected. Together with strong in-plane centrifugal forces, which bend the molecules by up to 10 deg, permanent field-free alignment offers new ways of controlling molecules with laser light. PMID:27203318

  19. Molecular Descriptors

    NASA Astrophysics Data System (ADS)

    Consonni, Viviana; Todeschini, Roberto

    In the last decades, several scientific researches have been focused on studying how to encompass and convert - by a theoretical pathway - the information encoded in the molecular structure into one or more numbers used to establish quantitative relationships between structures and properties, biological activities, or other experimental properties. Molecular descriptors are formally mathematical representations of a molecule obtained by a well-specified algorithm applied to a defined molecular representation or a well-specified experimental procedure. They play a fundamental role in chemistry, pharmaceutical sciences, environmental protection policy, toxicology, ecotoxicology, health research, and quality control. Evidence of the interest of the scientific community in the molecular descriptors is provided by the huge number of descriptors proposed up today: more than 5000 descriptors derived from different theories and approaches are defined in the literature and most of them can be calculated by means of dedicated software applications. Molecular descriptors are of outstanding importance in the research fields of quantitative structure-activity relationships (QSARs) and quantitative structure-property relationships (QSPRs), where they are the independent chemical information used to predict the properties of interest. Along with the definition of appropriate molecular descriptors, the molecular structure representation and the mathematical tools for deriving and assessing models are other fundamental components of the QSAR/QSPR approach. The remarkable progress during the last few years in chemometrics and chemoinformatics has led to new strategies for finding mathematical meaningful relationships between the molecular structure and biological activities, physico-chemical, toxicological, and environmental properties of chemicals. Different approaches for deriving molecular descriptors here reviewed and some of the most relevant descriptors are presented in

  20. Molecular Haeckel.

    PubMed

    Elinson, Richard P; Kezmoh, Lorren

    2010-07-01

    More than a century ago, Ernst Haeckel created embryo drawings to illustrate the morphological similarity of vertebrate early embryos. These drawings have been both widely presented and frequently criticized. At the same time that the idea of morphological similarity was recently attacked, there has been a growing realization of molecular similarities in the development of tissues and organs. We have surveyed genes expressed in vertebrate embryos, and we have used them to construct drawings that we call Molecular Haeckels. The Molecular Haeckels emphasize that, based on gene expression, there is a greater similarity among vertebrate embryos than even Haeckel might have imagined. PMID:20549737

  1. Minority Talent Loss and the Texas Top 10% Law

    PubMed Central

    Niu, Sunny Xinchun; Sullivan, Teresa; Tienda, Marta

    2012-01-01

    Objective To examine how knowledge about the Texas top 10% law influences college enrollment decisions of high achieving students minority and nonminority students. Data and Methods Using a representative survey of graduates from Texas public high schools in 2002, we compare self-reported and transcript-verified class rank and estimate probit models to assess the likelihood that top-ranked minority students know about the law. Results Family socioeconomic status largely explains why highly ranked black and Hispanic students know less about the top 10% law than comparable whites, but parents’ lack of fluency in English is a significant information barrier for college-bound, top 10% Hispanic students from predominantly minority high schools. Nearly one-fifth of college-oriented black and Hispanic top 10% seniors who did not know about the law failed to enroll anywhere. Conclusion Inadequate information about the top 10% law undermines enrollment of talented minorities in higher education. PMID:23293398

  2. Top-quark processes at NLO in production and decay

    SciTech Connect

    Campbell, John M.; Ellis, R.Keith

    2012-04-01

    We describe the implementation of top production and decay processes in the parton-level Monte Carlo program MCFM. By treating the top quark as being on-shell, we can factorize the amplitudes for top-pair production, s-channel single-top production, and t-channel single-top production into the product of an amplitude for production and an amplitude for decay. In this way we can retain all spin correlations. Both the production and the decay amplitudes are calculated consistently at next-to-leading order in alpha_s. The full dependence on the b-quark mass is also kept. Phenomenological results are presented for various kinematic distributions at the LHC and for the top quark forward-backward asymmetry at the Tevatron.

  3. Search for a heavy top t' to Wq in top events

    SciTech Connect

    Cox, David

    2009-10-01

    We present a search for a massive quark (t{prime}) decaying to Wq and thus mimicking the top quark decay signature in data collected by the CDF II detector corresponding to 2.8 fb{sup -1}. We use the reconstructed mass of the t{prime} quark and the scalar sum of the transverse energies in the event to discriminate possible new physics from Standard Model processes, and set limits on a standard 4th generation t{prime} quark.

  4. Top-down characterization data on the speciation of the Candida albicans immunome in candidemia

    PubMed Central

    Pitarch, Aida; Nombela, César; Gil, Concha

    2015-01-01

    The characterization of pathogen-specific antigenic proteins at the protein species level is crucial in the development and molecular optimization of novel immunodiagnostics, vaccines or immunotherapeutics for infectious diseases. The major requirements to achieve this molecular level are to obtain 100% sequence coverage and identify all post-translational modifications of each antigenic protein species. In this article, we show nearly complete sequence information for five discrete antigenic species of Candida albicans Tdh3 (glyceraldehyde-3-phosphate dehydrogenase), which have been reported to be differentially recognized both among candidemia patients and between candidemia and control patients. A comprehensive description of the top-down immunoproteomic strategy used for seroprofiling at the C. albicans protein species level in candidemia as well as for the chemical characterization of this immunogenic protein (based on high-resolution 2-DE, Western blotting, peptide mass fingerprinting, tandem mass spectrometry and de novo peptide sequencing) is also provided. The top-down characterization data on the speciation of the C. albicans immunome in candidemia presented here are related to our research article entitled “Seroprofiling at the Candida albicans protein species level unveils an accurate molecular discriminator for candidemia” (Pitarch et al., J. Proteomics, 2015, http://dx.doi.org/10.1016/j.jprot.2015.10.022). PMID:26862568

  5. Top-down characterization data on the speciation of the Candida albicans immunome in candidemia.

    PubMed

    Pitarch, Aida; Nombela, César; Gil, Concha

    2016-03-01

    The characterization of pathogen-specific antigenic proteins at the protein species level is crucial in the development and molecular optimization of novel immunodiagnostics, vaccines or immunotherapeutics for infectious diseases. The major requirements to achieve this molecular level are to obtain 100% sequence coverage and identify all post-translational modifications of each antigenic protein species. In this article, we show nearly complete sequence information for five discrete antigenic species of Candida albicans Tdh3 (glyceraldehyde-3-phosphate dehydrogenase), which have been reported to be differentially recognized both among candidemia patients and between candidemia and control patients. A comprehensive description of the top-down immunoproteomic strategy used for seroprofiling at the C. albicans protein species level in candidemia as well as for the chemical characterization of this immunogenic protein (based on high-resolution 2-DE, Western blotting, peptide mass fingerprinting, tandem mass spectrometry and de novo peptide sequencing) is also provided. The top-down characterization data on the speciation of the C. albicans immunome in candidemia presented here are related to our research article entitled "Seroprofiling at the Candida albicans protein species level unveils an accurate molecular discriminator for candidemia" (Pitarch et al., J. Proteomics, 2015, http://dx.doi.org/10.1016/j.jprot.2015.10.022). PMID:26862568

  6. Top Quark Pair Production Cross Section at the Tevatron

    SciTech Connect

    Peters, Reinhild Yvonne

    2015-09-25

    The top quark, discovered in 1995 by the CDF and D0 collaborations at the Tevatron proton antiproton collider at Fermilab, has undergone intense studies in the last 20 years. Currently, CDF and D0 converge on their measurements of top-antitop quark production cross sections using the full Tevatron data sample. In these proceedings, the latest results on inclusive and differential measurements of top-antitop quark production cross sections at the Tevatron are reported.

  7. Molecular printing

    PubMed Central

    Braunschweig, Adam B.; Huo, Fengwei; Mirkin, Chad A.

    2014-01-01

    Molecular printing techniques, which involve the direct transfer of molecules to a substrate with submicrometre resolution, have been extensively developed over the past decade and have enabled many applications. Arrays of features on this scale have been used to direct materials assembly, in nanoelectronics, and as tools for genetic analysis and disease detection. The past decade has witnessed the maturation of molecular printing led by two synergistic technologies: dip-pen nanolithography and soft lithography. Both are characterized by material and substrate flexibility, but dip-pen nanolithography has unlimited pattern design whereas soft lithography has limited pattern flexibility but is low in cost and has high throughput. Advances in DPN tip arrays and inking methods have increased the throughput and enabled applications such as multiplexed arrays. A new approach to molecular printing, polymer-pen lithography, achieves low-cost, high-throughput and pattern flexibility. This Perspective discusses the evolution and future directions of molecular printing. PMID:21378889

  8. Molecular Astrophysics

    NASA Astrophysics Data System (ADS)

    Hartquist, T. W.

    2005-07-01

    Part I. Molecular Clouds and the Distribution of Molecules in the Milky Way and Other Galaxies: 1. Molecular clouds in the Milky Way P. Friberg and A. Hjalmarson; 2. Molecules in galaxies L. Blitz; Part II. Diffuse Molecular Clouds: 3. Diffuse cloud chemistry E. F. Van Dishoeck; 4. Observations of velocity and density structure in diffuse clouds W. D. Langer; 5. Shock chemistry in diffuse clouds T. W. Hartquist, D. R. Flower and G. Pineau des Forets; Part III. Quiescent Dense Clouds: 6. Chemical modelling of quiescent dense interstellar clouds T. J. Millar; 7. Interstellar grain chemistry V. Buch; 8. Large molecules and small grains in astrophysics S. H. Lepp; Part IV. Studies of Molecular Processes: 9. Molecular photoabsorption processes K. P. Kirby; 10. Interstellar ion chemistry: laboratory studies D. Smith, N. G. Adams and E. E. Ferguson; 11. Theoretical considerations on some collisional processes D. R. Bates; 12. Collisional excitation processes E. Roueff; 13. Neutral reactions at Low and High Temperatures M. M. Graff; Part V. Atomic Species in Dense Clouds: 14. Observations of atomic species in dense clouds G. J. Melnick; 15. Ultraviolet radiation in molecular clouds W. G. Roberge; 16. Cosmic ray induced photodissociation and photoionization of interstellar molecules R. Gredel; 17. Chemistry in the molecular cloud Barnard 5 S. B. Charnley and D. A. Williams; 18. Molecular cloud structure, motions, and evolution P. C. Myers; Part VI. H in Regions of Massive Star Formation: 19. Infrared observations of line emission from molecular hydrogen T. R. Geballe; 20. Shocks in dense molecular clouds D. F. Chernoff and C. F. McKee; 21. Dissociative shocks D. A. Neufeld; 22. Infrared molecular hydrogen emission from interstellar photodissociation regions A. Sternberg; Part VII. Molecules Near Stars and in Stellar Ejecta: 23. Masers J. M. Moran; 24. Chemistry in the circumstellar envelopes around mass-losing red giants M. Jura; 25. Atoms and molecules in supernova 1987a R

  9. Molecular Spintronics using Molecular Nanomagnets

    NASA Astrophysics Data System (ADS)

    Wernsdorfer, Wolfgang

    2009-03-01

    A revolution in electronics is in view, with the contemporary evolution of two novel disciplines, spintronics and molecular electronics. A fundamental link between these two fields can be established using molecular magnetic materials and, in particular, single-molecule magnets [1], which combine the classic macroscale properties of a magnet with the quantum properties of a nanoscale entity. The resulting field, molecular spintronics aims at manipulating spins and charges in electronic devices containing one or more molecules. In this context, we want to fabricate, characterize and study molecular devices (molecular spin-transistor, molecular spin-valve and spin filter, molecular double-dot devices, carbon nanotube nano-SQUIDs, etc.) in order to read and manipulate the spin states of the molecule and to perform basic quantum operations. The talk will discuss this--still largely unexplored--field and present our the first important results [2,3].[4pt] [1] L. Bogani & W. Wernsdorfer, Nature Mat. 7, 179 (2008).[0pt] [2] J.-P. Cleuziou, W. Wernsdorfer, V. Bouchiat, T. Ondarcuhu, M. Monthioux, Nature Nanotech. 1, 53-59 (2006).[0pt] [3] N. Roch, S. Florens, V. Bouchiat, W. Wernsdorfer, F. Balestro, Nature 453, 633 (2008).

  10. 22. VIEW SECOND FLOOR, TOP VIEW OF ELEVATOR WITH WINCHING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    22. VIEW SECOND FLOOR, TOP VIEW OF ELEVATOR WITH WINCHING MECHANISM, LOOKING NORTHWEST - Bates Manufacturing Company, Storehouse, Northeast corner of Chestnut Street & Hines Alley, Lewiston, Androscoggin County, ME

  11. 21. VIEW SECOND FLOOR, ELEVATOR SHAFT, TOP ELEVATOR SUPPORT, LOOKING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    21. VIEW SECOND FLOOR, ELEVATOR SHAFT, TOP ELEVATOR SUPPORT, LOOKING NORTHWEST - Bates Manufacturing Company, Storehouse, Northeast corner of Chestnut Street & Hines Alley, Lewiston, Androscoggin County, ME

  12. Studies of top quark properties at the Tevatron

    SciTech Connect

    Shary, Viatcheslav

    2012-05-01

    An overview of the recent measurements of the top quark properties in proton antiproton collisions at {radical}s = 1.96 TeV is presented. These measurements are based on 5.4-8.7 fb{sup -1} of data collected with the D0 and CDF experiments at the Fermilab Tevatron collider. The top quark mass and width measurements, studies of the spin correlation in top quark pair production, W boson helicity measurement, searches for anomalous top quark couplings and Lorentz invariance violation are discussed.

  13. Community Evolution in International Migration Top1 Networks

    PubMed Central

    Xu, Helian

    2016-01-01

    Focusing on each country’s topmost destination/origin migration relation with other countries, this study builds top1 destination networks and top1 origin networks in order to understand their skeletal construction and community dynamics. Each top1 network covers approximately 50% of the complete migrant network stock for each decade between 1960 and 2000. We investigate the community structure by implementing the Girvan-Newman algorithm and compare the number of components and communities to illustrate their differences. We find that (i) both top1 networks (origin and destination) exhibited communities with a clear structure and a surprising evolution, although 80% edges persist between each decade; (ii) top1 destination networks focused on developed countries exhibiting shorter paths and preferring more advance countries, while top1 origin networks focused both on developed as well as more substantial developing nations that presented a longer path and more stable groups; (iii) only few countries have a decisive influence on community evolution of both top1 networks. USA took the leading position as a destination country in top1 destination networks, while China and India were the main Asian emigration countries in top1 origin networks; European countries and the Russian Federation played an important role in both. PMID:26859406

  14. Community Evolution in International Migration Top1 Networks.

    PubMed

    Peres, Mihaela; Xu, Helian; Wu, Gang

    2016-01-01

    Focusing on each country's topmost destination/origin migration relation with other countries, this study builds top1 destination networks and top1 origin networks in order to understand their skeletal construction and community dynamics. Each top1 network covers approximately 50% of the complete migrant network stock for each decade between 1960 and 2000. We investigate the community structure by implementing the Girvan-Newman algorithm and compare the number of components and communities to illustrate their differences. We find that (i) both top1 networks (origin and destination) exhibited communities with a clear structure and a surprising evolution, although 80% edges persist between each decade; (ii) top1 destination networks focused on developed countries exhibiting shorter paths and preferring more advance countries, while top1 origin networks focused both on developed as well as more substantial developing nations that presented a longer path and more stable groups; (iii) only few countries have a decisive influence on community evolution of both top1 networks. USA took the leading position as a destination country in top1 destination networks, while China and India were the main Asian emigration countries in top1 origin networks; European countries and the Russian Federation played an important role in both. PMID:26859406

  15. TOP AND HIGGS PHYSICS AT THE HADRON COLLIDERS

    SciTech Connect

    Jabeen, Shabnam

    2013-10-20

    This review summarizes the recent results for top quark and Higgs boson measurements from experiments at Tevatron, a proton–antiproton collider at a center-of-mass energy of √ s =1 . 96 TeV, and the Large Hadron Collider, a proton–proton collider at a center- of-mass energy of √ s = 7 TeV. These results include the discovery of a Higgs-like boson and measurement of its various properties, and measurements in the top quark sector, e.g. top quark mass, spin, charge asymmetry and production of single top quark.

  16. Recent Results on Top-Quark Physics at D0

    SciTech Connect

    Bloom, Kenneth

    2015-10-23

    We present the most recent measurements on top-quark physics obtained with Tevatron $p\\bar{p}$ collisions recorded by the D0 experiment at $\\sqrt{s}= 1.96$ TeV. The full Run II data set of 9.7 fb$^{-1}$ is analyzed. Both lepton+jets and dilepton channels of top-quark pair production are used to measure the differential and inclusive cross sections, the forward-backward asymmetries, the top-quark mass, the spin correlations, and the top-quark polarization.

  17. Measurements of Top Quark Properties at the Tevatron

    SciTech Connect

    Mietlicki, David J.; /Michigan U.

    2012-04-01

    The top quark is the most recently discovered of the standard model quarks, and studies of its properties are important tests of the standard model. Many measurements of top properties have been produced by the CDF and D0 collaborations, which study top quarks produced in p{bar p} collisions at the Fermilab Tevatron with a center-of-mass energy {radical}s = 1.96 TeV. We describe recent results from top properties measurements at the Tevatron using datasets corresponding to integrated luminosities up to 8.7 fb{sup -1}.

  18. 43. TOP OF SOUTHEAST TOWER FROM SOUTH TOWER ROOF, LOOKING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    43. TOP OF SOUTHEAST TOWER FROM SOUTH TOWER ROOF, LOOKING EAST - Smithsonian Institution Building, 1000 Jefferson Drive, between Ninth & Twelfth Streets, Southwest, Washington, District of Columbia, DC

  19. Interareal oscillatory synchronization in top-down neocortical processing.

    PubMed

    Bressler, Steven L; Richter, Craig G

    2015-04-01

    Top-down processing in the neocortex underlies important cognitive functions such as predictive coding and attentional set. We review evidence indicating that top-down neocortical processes are carried by interareal synchrony, particularly in the beta frequency band. We hypothesize that top-down neocortical signals in the beta band convey behavioral context to low-level sensory neurons. We further speculate that large-scale distributed networks, self-organized at the highest hierarchical levels, are the source of top-down signals in the neocortex. PMID:25217807

  20. Getting to the top of Google: search engine optimization.

    PubMed

    Maley, Catherine; Baum, Neil

    2010-01-01

    Search engine optimization is the process of making your Web site appear at or near the top of popular search engines such as Google, Yahoo, and MSN. This is not done by luck or knowing someone working for the search engines but by understanding the process of how search engines select Web sites for placement on top or on the first page. This article will review the process and provide methods and techniques to use to have your site rated at the top or very near the top. PMID:20480779

  1. Top leasing for oil and gas: the legal perspective

    SciTech Connect

    Kemp, J.H.

    1982-01-01

    Top leasing, whereby a lessee acquires a lease on a mineral estate currently under a valid, existing lease, is a phenomenon with legal ramifications that has been reported for more than 50 years. An examination of the judicial decisions involving top leases reveals that litigation can arise in a number of different circumstances. For example, the top lease must expressly recognize the existence of the prior lease and be subject to it. The top lessee should conduct an independent title search and obtain an attorney's title opinion before drilling. He should conduct a surface examination and obtain releases for any prior unreleased oil and gas leases. 109 references.

  2. Single top quark production and Vtb at the Tevatron

    SciTech Connect

    Schwienhorst, Reinhard; /Michigan State U.

    2010-09-01

    Single top quark production via the electroweak interaction was observed by the D0 and CDF collaborations at the Tevatron proton-antiproton collider at Fermilab. Multivariate analysis techniques are employed to extract the small single top quark signal. The combined Tevatron cross section is 2.76{sub -0.47}{sup +0.58} pb. This corresponds to a lower limit on the CKM matrix element |V{sub tb}| of 0.77. Also reported are measurements of the t-channel cross section, the top quark polarization in single top quark events, and limits on gluon-quark flavor-changing neutral currents and W{prime} boson production.

  3. Studies of single top quark production at the Tevatron

    SciTech Connect

    Quinn, Breese; /Mississippi U.

    2011-01-01

    In this paper we present several measurements of single top quark production from the CDF and D0 experiments at the Tevatron. The various analyses utilize integrated luminosity ranging from 2.1 to 4.8 fb{sup -1}. The results include the observation of single top production with a combined cross section of 2.76{sub -0.47}{sup +0.58} pb for a top quark mass of 170 GeV/c{sup 2}, as well as measurements of top quark polarization and first evidence for t-channel production.

  4. Higgs bosons from top quark decays

    NASA Astrophysics Data System (ADS)

    Han, Tao; Ruiz, Richard

    2014-04-01

    In light of the discovery of a standard model (SM)-like Higgs boson (h) at the LHC, we investigate the top quark to Higgs boson transition t→W*bh, which is the leading t→h decay mode in the SM. We find the decay branching fraction to be 1.80×10-9. In comparison, the two-body, loop-induced t→ch transition occurs at ˜10-14 in the SM. We consider the consequences of gauge-invariant dimension-six operators affecting the tt ¯h interaction and find that the decay branching fraction may be increased by a factor of 2 within current constraints on the coupling parameters from collider experiments. We also extend the calculation to the CP-conserving Type I and Type II two-Higgs-doublet models, including both CP-even and CP-odd Higgs bosons. For neutral scalar masses at about 100 GeV, the decay rates can be several times larger than the SM result in the allowed range of model parameters. Observation prospects at present and future colliders are briefly addressed.

  5. New type of hill-top inflation

    NASA Astrophysics Data System (ADS)

    Barvinsky, A. O.; Kamenshchik, A. Yu.; Nesterov, D. V.

    2016-01-01

    We suggest a new type of hill-top inflation originating from the initial conditions in the form of the microcanonical density matrix for the cosmological model with a large number of quantum fields conformally coupled to gravity. Initial conditions for inflation are set up by cosmological instantons describing underbarrier oscillations in the vicinity of the inflaton potential maximum. These periodic oscillations of the inflaton field and cosmological scale factor are obtained within the approximation of two coupled oscillators subject to the slow roll regime in the Euclidean time. This regime is characterized by rapid oscillations of the scale factor on the background of a slowly varying inflaton, which guarantees smallness of slow roll parameters epsilon and η of the following inflation stage. A hill-like shape of the inflaton potential is shown to be generated by logarithmic loop corrections to the tree-level asymptotically shift-invariant potential in the non-minimal Higgs inflation model and R2-gravity. The solution to the problem of hierarchy between the Planckian scale and the inflation scale is discussed within the concept of conformal higher spin fields, which also suggests the mechanism bringing the model below the gravitational cutoff and, thus, protecting it from large graviton loop corrections.

  6. Beam uniformity of flat top lasers

    NASA Astrophysics Data System (ADS)

    Chang, Chao; Cramer, Larry; Danielson, Don; Norby, James

    2015-03-01

    Many beams that output from standard commercial lasers are multi-mode, with each mode having a different shape and width. They show an overall non-homogeneous energy distribution across the spot size. There may be satellite structures, halos and other deviations from beam uniformity. However, many scientific, industrial and medical applications require flat top spatial energy distribution, high uniformity in the plateau region, and complete absence of hot spots. Reliable standard methods for the evaluation of beam quality are of great importance. Standard methods are required for correct characterization of the laser for its intended application and for tight quality control in laser manufacturing. The International Organization for Standardization (ISO) has published standard procedures and definitions for this purpose. These procedures have not been widely adopted by commercial laser manufacturers. This is due to the fact that they are unreliable because an unrepresentative single-pixel value can seriously distort the result. We hereby propose a metric of beam uniformity, a way of beam profile visualization, procedures to automatically detect hot spots and beam structures, and application examples in our high energy laser production.

  7. Top quark physics at the Tevatron

    SciTech Connect

    Bhat, P.C.

    1998-04-01

    The authors review the analyses of t{bar t} candidate events in various decay channels, carried out using the p{bar p} collider data at {radical}s = 1.8 TeV by the CDF and D0 collaborations at the Fermilab Tevatron. The measurements of the top quark mass (m{sub t}) using lepton+jets channel yield m{sub t} = 173.3 {+-} 7.8 GeV/c{sup 2} from D0 analysis and m{sub t} = 175.9 {+-} 6.9 GeV/c{sup 2} from CDF analysis. The production cross section is measured to be {sigma}{sub t{bar t}} = 7.6{sub -1.5}{sup +1.8} pb by CDF and {sigma}{sub t{bar t}} = 5.6 {+-} 1.8 pb by D0. Further investigations using t{bar t} decays and future prospects are briefly discussed.

  8. Over the top: Experiment and the testing of hypotheses in the search for the top quark

    NASA Astrophysics Data System (ADS)

    Staley, Kent Wade

    1998-07-01

    This study presents a historical account of experiments, performed by the Collider Detector at Fermilab (CDF) collaboration, which led to the discovery of the top quark, and a discussion of philosophical issues raised by that episode. The historical discussion is based on published and unpublished documents and oral history interviews, and is presented in two parts: First, the formation of the collaboration and construction of the detector are described. The activities of the collaborators during the period of detector construction are described in terms of the development of resources for a general experimental programme. Second, the development of the means of analyzing the data for the top quark search is described, particularly aspects of the analysis that were disputed. The hypothesis that collaboration researchers have come to regard the social process of resolving disputes as a matter of methodological importance is suggested. The philosophical discussion of the experiment employs the hierarchy of models approach of Patrick Suppes and Deborah Mayo in order to examine the logic of hypothesis testing and draw some conclusions regarding the nature of scientific evidence. In an extension of an argument presented by Peter Achinstein, the account of hypothesis testing given by hypothetico-deductivist philosophers such as Karl Popper and R. B. Braithwaite is examined in light of the reasoning employed in the top search, and is found wanting. The prediction based on the hypothesis being tested in the top search is found to have been inferred inductively from the experimental data. Finally, a discussion is presented of tuning on the signal, a form of bias in the testing of hypotheses. The proscription of this form of bias resembles John Worrall's requirement of use novelty, but is shown instead to serve the aim of devising a test of the hypothesis that is severe, in the sense articulated by Deborah Mayo. It is shown that the evaluation of evidence claims, as it

  9. Remote sensing of cloud-top pressure using reflected solar radiation in the oxygen A-band

    NASA Technical Reports Server (NTRS)

    Wu, M.-L. C.

    1985-01-01

    An algorithm has been developed for using the reflection of solar radiation in the oxygen A-band to determine cloud-top altitude. Because of multiple scattering and molecular absorption inside the cloud, the reflection of clouds is substantially modified in comparison with a mirror cloud, which is assumed to have a 100 percent reflection. To infer true cloud-top altitude, therefore, it is necessary to accurately estimate the amount of 'photon penetration'. Theoretical calculations indicate that the amount of photon penetration depends on the altitude, the scaled volume scattering coefficient, and the scaled optical thickness of the cloud. Algorithms using the reflection in the oxygen A-band to determine the cloud-top pressure have been applied to an aircraft field experiment in conjunction with CCOPE, 1981. Results of this study are very encouraging, especially for extended clouds.

  10. Analysis of the Microwave Spectrum of the Three-Top Molecule Trimethoxylmethane

    NASA Astrophysics Data System (ADS)

    Coudert, L. H.; Feng, G.; Caminati, W.

    2013-06-01

    Although many investigations about the spectrum of molecules displaying internal rotation of one or two methyl tops have been reported, there are much fewer results about the spectrum of molecules with three methyl tops. In this paper, we will deal with the microwave spectrum of trimethoxylmethane, HC(OCH_3)_3, a molecule displaying three conformers of quite different symmetry which all exhibit internal rotation of their three methyl tops. In a first step, a theoretical approach dedicated to the calculation of the rotation-torsion energy levels of a molecule with three inequivalent tops was developed. The model is based on a DVR approach; it accounts accurately for the rotation-torsion Coriolis couplings due to the torsion of each methyl top and leads to matrices which are smaller than those arising with the usual free internal rotation functions. The theoretical approach shows that internal rotation of the three tops leads to 27 tunneling sublevels, including 13 doubly degenerate ones. The statistical weights of the sublevels are 2^4, 2^5, and 2^6. The microwave spectrum of trimethoxylmethane has been recorded from to 10 to 19 GHz with the molecular beam Fourier transform spectrometer of the University of Bologna. The spectra of the TMM1, TMM2, and TMM3 conformers with C_1, C_3, and C_s symmetry, respectively, have been observed. The theoretical model has been applied to the lowest lying TMM1 conformer since it is the only one with three inequivalent methyl tops. The parameters describing the rotational energy and the rotation-torsion Coriolis couplings were obtained from the geometry of the conformer and those corresponding to height of the barriers hindering the internal rotations were retrieved through ab initio calculations. Calculated tunneling patterns were compared to experimental ones. As far as the number of tunneling components is concerned, there is a qualitative agreement between experiment and theory. However, the present calculation seems to

  11. Towards an upper level ontology for molecular biology.

    PubMed

    Schulz, Stefan; Beisswanger, Elena; Wermter, Joachim; Hahn, Udo

    2006-01-01

    There is a growing need for the general-purpose description of the basic conceptual entities in the life sciences. Up until now, upper level models have mainly been purpose-driven, such as the GENIA ontology, originally devised as a vocabulary for corpus annotation. As an alternative,we here present BioTop, a description-logic-based top level ontology for molecular biology, which we consider as an ontologically conscious redesign of the GENIA ontology. PMID:17238430

  12. Analysis and numerical simulation of a laboratory analog of radiatively induced cloud-top entrainment.

    SciTech Connect

    Kerstein, Alan R.; Sayler, Bentley J.; Wunsch, Scott Edward; Schmidt, Heiko; Nedelec, Renaud

    2010-11-01

    Numerical simulations using the One-Dimensional-Turbulence model are compared to water-tank measurements [B. J. Sayler and R. E. Breidenthal, J. Geophys. Res. 103 (D8), 8827 (1998)] emulating convection and entrainment in stratiform clouds driven by cloud-top cooling. Measured dependences of the entrainment rate on Richardson number, molecular transport coefficients, and other experimental parameters are reproduced. Additional parameter variations suggest more complicated dependences of the entrainment rate than previously anticipated. A simple algebraic model indicates the ways in which laboratory and cloud entrainment behaviors might be similar and different.

  13. Molecular fountain.

    SciTech Connect

    Strecker, Kevin E.; Chandler, David W.

    2009-09-01

    A molecular fountain directs slowly moving molecules against gravity to further slow them to translational energies that they can be trapped and studied. If the molecules are initially slow enough they will return some time later to the position from which they were launched. Because this round trip time can be on the order of a second a single molecule can be observed for times sufficient to perform Hz level spectroscopy. The goal of this LDRD proposal was to construct a novel Molecular Fountain apparatus capable of producing dilute samples of molecules at near zero temperatures in well-defined user-selectable, quantum states. The slowly moving molecules used in this research are produced by the previously developed Kinematic Cooling technique, which uses a crossed atomic and molecular beam apparatus to generate single rotational level molecular samples moving slowly in the laboratory reference frame. The Kinematic Cooling technique produces cold molecules from a supersonic molecular beam via single collisions with a supersonic atomic beam. A single collision of an atom with a molecule occurring at the correct energy and relative velocity can cause a small fraction of the molecules to move very slowly vertically against gravity in the laboratory. These slowly moving molecules are captured by an electrostatic hexapole guiding field that both orients and focuses the molecules. The molecules are focused into the ionization region of a time-of-flight mass spectrometer and are ionized by laser radiation. The new molecular fountain apparatus was built utilizing a new design for molecular beam apparatus that has allowed us to miniaturize the apparatus. This new design minimizes the volumes and surface area of the machine allowing smaller pumps to maintain the necessary background pressures needed for these experiments.

  14. Prognostication of prostate cancer based on TOP2A protein and gene assessment: TOP2A in prostate cancer

    PubMed Central

    2013-01-01

    Background TOP2A encodes for topoisomerase IIα, a nuclear enzyme that controls DNA topological structure and cell cycle progression. This enzyme is a marker of cell proliferation in normal and neoplastic tissues; however, little information is available about its expression in prostate cancer (PCa). Methods Immunohistochemistry (IHC) was automated using mouse monoclonal antibody against TOP2A (clone SWT3D1; DAKO, Carpenteria, CA, USA) at dilution 1:800 and Flex Plus detection system in autostainer 48Ultra (DAKO). FISH was performed using TOP2A (17q21)/ CEP17 probe kit (Kreateck Biotechnology, San Diego, CA, USA). Biochemical and pathological data from 193 patients with PCa were retrieved for the analysis, whose significance was considered when p < 0.05. Also, fractal analysis was performed in a subset of 20 randomly selected cases. Results TOP2A protein expression correlated with higher Gleason scores and higher levels of preoperative PSA (p = 0.018 and p = 0.011). Patients with higher levels of TOP2A presented shorter biochemical recurrence-free survival (BRFS) (p = 0.001). In multivariate analysis, we found that TOP2A remained an independent prognostic factor of BRFS, with a relative risk of 1.98 (p = 0.001; 95% CI, 1.338–2.93); thus, cases that expressed high levels of this enzyme had a shorter BRFS compared with TOP2A-negative or TOP2A-low cases. No alterations in TOP2A gene status nor correlation between FISH and IHC results were observed. Concerning fractal analysis, patients who expressed higher levels of TOP2A have angiolymphatic invasion and presented higher Gleason scores (p = 0.033 and p = 0.025, respectively). Also, patients with higher expression of TOP2A presented shorter BRFS (p = 0.001). Conclusions This is the first study to perform TOP2A protein and gene digital assessment and fractal analysis in association with BRFS in a large series of PCa. Also, we show that TOP2A gene copy number alterations are not observed

  15. Nanoparticles for Imaging: Top or Flop?

    PubMed Central

    Mertens, Marianne E.; Grimm, Jan; Lammers, Twan

    2014-01-01

    Nanoparticles are frequently suggested as diagnostic agents. However, except for iron oxide nanoparticles, diagnostic nanoparticles have been barely incorporated into clinical use so far. This is predominantly due to difficulties in achieving acceptable pharmacokinetic properties and reproducible particle uniformity as well as to concerns about toxicity, biodegradation, and elimination. Reasonable indications for the clinical utilization of nanoparticles should consider their biologic behavior. For example, many nanoparticles are taken up by macrophages and accumulate in macrophage-rich tissues. Thus, they can be used to provide contrast in liver, spleen, lymph nodes, and inflammatory lesions (eg, atherosclerotic plaques). Furthermore, cells can be efficiently labeled with nanoparticles, enabling the localization of implanted (stem) cells and tissue-engineered grafts as well as in vivo migration studies of cells. The potential of using nanoparticles for molecular imaging is compromised because their pharmacokinetic properties are difficult to control. Ideal targets for nanoparticles are localized on the endothelial luminal surface, whereas targeted nanoparticle delivery to extravascular structures is often limited and difficult to separate from an underlying enhanced permeability and retention (EPR) effect. The majority of clinically used nanoparticle-based drug delivery systems are based on the EPR effect, and, for their more personalized use, imaging markers can be incorporated to monitor biodistribution, target site accumulation, drug release, and treatment efficacy. In conclusion, although nanoparticles are not always the right choice for molecular imaging (because smaller or larger molecules might provide more specific information), there are other diagnostic and theranostic applications for which nanoparticles hold substantial clinical potential. PMID:25247562

  16. Ice-frosted crater tops on Ganymede

    NASA Technical Reports Server (NTRS)

    1996-01-01

    Scientists believe that water-ice frosts are the likely cause for the brightening seen around the circular rims of these craters located at a high northern latitude (57 degrees) on Jupiter's moon Ganymede in this image taken by NASA's Galileo spacecraft on September 6, 1996. The image, just recently radioed to Earth from the spacecraft, shows the same kind of bright, high-latitude surface areas as those first seen by the Voyager spacecraft in 1979, but at higher resolution (this image spans about 18 kilometers or 11 miles on a side). Even though the Sun is shining from the south, the north-facing walls of the ridges and craters are brighter than the walls facing the Sun. This is interpreted to mean that the very bright north-facing slopes are covered with surface water-ice frosts, and that these frosts preferentially accumulate in such high-latitude locations. Galileo scientists say that at the high resolution seen in Galileo images, the high-latitude brightness seen by Voyager is partly attributable to frosts forming on cooler, north-facing slopes.

    The right-hand side of the image is dominated by a north-south line of impact craters; the smallest ones at the top are about 2 kilometers (1.2 miles) in diameter and the large one at the bottom is about 5 kilometers (about 3 miles) in diameter. Ganymede is the largest moon in the solar system, larger than the planet Mercury and nearly the size of Mars.

    The Jet Propulsion Laboratory, Pasadena, CA, manages the mission for NASA's Office of Space Science, Washington, DC. This image and other images and data received from Galileo are posted on the Galileo mission home page on the World Wide Web at http://galileo.jpl.nasa.gov. Background information and educational context for the images can be found at http://www.jpl.nasa.gov/galileo/sepo

  17. The new deal at the top.

    PubMed

    Doz, Yves L; Kosonen, Mikko

    2007-06-01

    What makes a company strategically agile--able to alter its strategies and business models rapidly in response to major changes in its market space, and to do so repeatedly without major trauma? Three years of in-depth case research on a dozen large companies worldwide showed the authors that one key factor is a new leadership model at the top. Senior executives at agile companies assume collective rather than individual responsibility for results. They build interdependencies among units and divisions, motivating themselves to engage with one another, and carefully manage their dealings to promote collaboration that is frequent, intense, informal, open, and focused on shared issues and the long term. Challenges to conventional thinking are encouraged. This is the new deal, and it's not easy to strike, because it requires executives to act in ways that are far from comfortable. After all, the corporate ladder at most firms favors independent types with a deep need for power and autonomy. At executive meetings, disagreement is suppressed or expressed passive-aggressively, eroding any real sense of belonging to a team. Switching to the new deal almost always requires a huge shift in the company's culture, values, and norms of interaction. The authors describe three approaches to making the shift: Executives can be given formal responsibility not for a business unit but for different stages in the company's value chain. This worked well for SAP, which has a relatively focused business portfolio. When a company's portfolio is less uniform, like Nokia's, business and functional units can be organized to crisscross on a matrix. And when a company is widely diverse, like easyGroup, it can emphasize the learning opportunities that units with common business models may share. PMID:17580652

  18. Compatibility of top antireflective coatings and photoresists

    NASA Astrophysics Data System (ADS)

    Li, Ju-Yau; Chuang, Po-Wei; Hsu, Chih-Hsieh F.; Jang, Ben; Chung, Wen-Jye

    1997-08-01

    To improve lithographic process throughput, it has become a general trend to link coater, stepper, and developer to an integrated PHOTO cell. In fine photolithography, TARC (top anti-reflective coating) is utilized intensively to obtain better CD (critical dimension) control. However, the coating of photoresist and TARC is not performed successively. A baking step about 90 seconds is employed in between these two coating steps. Throughput is thus affected and coating step becomes the bottleneck of whole lithography process. A series of experiments were investigated to coat TARC right after photoresist coatings. Results show that throughput was greatly improved. But for certain TARC and photoresist pairs, resist scumming due to inter-mixing of these two chemicals was found after exposure and developing. In some cases, the coater drain piping was stuck by the occurrence of precipitation resulted from the interaction between TARC and photoresist. To prevent this event from happening, precipitation tests of TARC and photoresist are investigated. Experiment was performed by adding TARC to photo resist with/without dilution by thinner. The occurrence of precipitation was observed. Seven kinds of photo resist and three kinds of TARC, provided by different vendors, are studied at different volume ratios on these tests. Results show that the lower photoresist to TARC ratio is, the more precipitation formed. Adding thinner, affecting the precipitation in different ways, induces more precipitation in most cases and cause the precipitation to disappear in some systems. One TARC is found to be inert to most photo resists. Photo resists with higher viscosity turn to gel when interacting with TARC.

  19. Top-Down Management: An Effective Tool in Higher Education?

    ERIC Educational Resources Information Center

    Tsai, Yau; Beverton, Sue

    2007-01-01

    Purpose: The purpose of this paper is to explore the strengths and weaknesses of top-down management in a university that has embraced globalisation with a strong market-led ethos and to suggest the ways in which adjustments might be made to top-down management processes. Design/methodology/approach: The paper examines the strengths and weaknesses…

  20. Teachers Pick the Top 50 Kids Books Ever

    ERIC Educational Resources Information Center

    Instructor, 2006

    2006-01-01

    This article presents the top 25 best picture and chapter books according to a survey of more than 200 teachers, children's authors, and children's literature experts. Included in the top 10 picture books are: (1) "Where the Wild Things Are" by Maurice Sendak (HarperCollins); (2) "The Very Hungry Caterpillar" by Eric Carle (Penguin); (3) "The…

  1. Delaware Pushes to Meet Race to Top Promises

    ERIC Educational Resources Information Center

    McNeil, Michele

    2011-01-01

    This article reports on how Delaware pushes to meet Race to the Top promises. The Delcastle Technical High School teachers are on the front lines of the push to deliver on promises that last year won Delaware, 10 other states, and the District of Columbia shares of the Race to the Top pie, the $4 billion competition that is driving much of the…

  2. 10. TIP TOP MINE. INTERIOR VIEW OF LIVING QUARTERS WITH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. TIP TOP MINE. INTERIOR VIEW OF LIVING QUARTERS WITH CLOSET/HANGER AND VIEW INTO ORE ROOM. RAIL IS VISIBLE JUST THROUGH DOOR WAY. CAMERA POINTED NORTH-NORTHWEST. - Florida Mountain Mining Sites, Tip Top Mine, West face Florida Mountain, approximately 150 feet below summit, Silver City, Owyhee County, ID

  3. Identification of Topping Responsive Proteins in Tobacco Roots

    PubMed Central

    Li, Fei; Zhang, Huizhen; Wang, Shaoxin; Xiao, Wanfu; Ding, Chao; Liu, Weiqun; Guo, Hongxiang

    2016-01-01

    The process of topping elicits many responses in the tobacco plant, including an increase in nicotine biosynthesis, and the secondary growth of roots. Some topping responsive miRNAs and genes have been identified in our previous study, but the mechanism of the tobacco response to topping has not yet been fully elucidated. In this study, topping responsive proteins isolated from tobacco roots were screened using two-dimensional electrophoresis. Of the proteins identified, calreticulin and auxin-responsive protein indole acetic acid (IAA9) were involved in the secondary growth of roots; leucine-rich repeat disease resistance, heat shock protein 70, and farnesyl pyrophosphate synthase 1 were involved in the wounding stress response; and F-box protein played an important role in promoting the ability of nicotine synthesis after topping. In addition, we identified five tobacco bHLH proteins (NtbHLH, NtMYC1a, NtMYC1b, NtMYC2a, and NtMYC2b) related to nicotine biosynthesis. NtMYC2 was suggested to be the main positive transcription factor, with NtbHLH protein being a negative regulator in the jasmonic acid (JA)-mediated activation of nicotine biosynthesis after topping. Tobacco topping activates a comprehensive range of biological processes involving the IAA and JA signaling pathways, and the identification of proteins involved in these processes will improve our understanding of the topping response. PMID:27200055

  4. 63. CANAL BOAT IN CRADLE AT TOP OF PLANE. TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    63. CANAL BOAT IN CRADLE AT TOP OF PLANE. TO PASS OVER THE SUMMIT (THE HUMP OF LAND AT THE TOP OF PLANE TO HOLD BACK THE WATER AT THAT LEVEL), THE BOATS HAVE SEEN HINGED AND TWO CRADLES ARE USED TO CARRY THE BOAT UP THE PLANE. - Morris Canal, Phillipsburg, Warren County, NJ

  5. Identification of Topping Responsive Proteins in Tobacco Roots.

    PubMed

    Li, Fei; Zhang, Huizhen; Wang, Shaoxin; Xiao, Wanfu; Ding, Chao; Liu, Weiqun; Guo, Hongxiang

    2016-01-01

    The process of topping elicits many responses in the tobacco plant, including an increase in nicotine biosynthesis, and the secondary growth of roots. Some topping responsive miRNAs and genes have been identified in our previous study, but the mechanism of the tobacco response to topping has not yet been fully elucidated. In this study, topping responsive proteins isolated from tobacco roots were screened using two-dimensional electrophoresis. Of the proteins identified, calreticulin and auxin-responsive protein indole acetic acid (IAA9) were involved in the secondary growth of roots; leucine-rich repeat disease resistance, heat shock protein 70, and farnesyl pyrophosphate synthase 1 were involved in the wounding stress response; and F-box protein played an important role in promoting the ability of nicotine synthesis after topping. In addition, we identified five tobacco bHLH proteins (NtbHLH, NtMYC1a, NtMYC1b, NtMYC2a, and NtMYC2b) related to nicotine biosynthesis. NtMYC2 was suggested to be the main positive transcription factor, with NtbHLH protein being a negative regulator in the jasmonic acid (JA)-mediated activation of nicotine biosynthesis after topping. Tobacco topping activates a comprehensive range of biological processes involving the IAA and JA signaling pathways, and the identification of proteins involved in these processes will improve our understanding of the topping response. PMID:27200055

  6. Slow Manifold and Hannay Angle in the Spinning Top

    ERIC Educational Resources Information Center

    Berry, M. V.; Shukla, P.

    2011-01-01

    The spin of a top can be regarded as a fast variable, coupled to the motion of the axis which is slow. In pure precession, the rotation of the axis round a cone (without nutation), can be considered as the result of a reaction from the fast spin. The resulting restriction of the total state space of the top is an illustrative example, at…

  7. \\ttbar and single top cross sections at the Tevatron

    SciTech Connect

    CDF, Elizaveta Shabalina for; collaborations, D0

    2012-01-01

    We present a summary of the latest measurements of the top pair and single top cross sections performed by the CDF and D0 collaborations at the Fermilab Tevatron collider. The Fermilab Tevatron collider ended its run on September 30, 2011 after delivering more than 10 fb{sup -1} of p{bar p} collision data per experiment at {radical}s = 1.96 TeV. A large sample of top quarks collected by the CDF and D0 experiments allows to perform precision measurements of their production which is predicted to occur within the standard model (SM) either in pairs via strong interactions or as single top events via electroweak interactions. Such measurements represent an important test of the theoretical calculations which predict the t{bar t} and single top production cross sections with a precision of 6% to 8% and 5%, respectively. Precise measurements of top pair cross section ({sigma}{sub t{bar t}}) in different t{bar t} final states and single top production via different production mechanisms are highly desirable as they are sensitive to the non-SM particles that may appear in top quark production or decays.

  8. Top 100 Undergraduate Degree Producers--Interpreting the Data

    ERIC Educational Resources Information Center

    Borden, Victor M. H.

    2008-01-01

    This article presents "Diverse Online's" annual analysis of the Top 100 degrees conferred to African-American students. The tables in this edition of the Top 100 analysis reflect degrees conferred during the 2006-2007 academic year as of mid March 2008 by the vast majority of U.S. postsecondary institutions to the Department of Education's…

  9. Desk Top Graffiti in an English High School Classroom.

    ERIC Educational Resources Information Center

    Sanfiorenzo, Norberto R.

    Psychologists and sociologists recognize the importance of graffiti, yet there is a lack of information on the content of high school desk top graffiti. To study desk top graffiti, a 9th and 10th grade English classroom located in an inner city high school in the southeastern United States was found in which graffiti was written on nearly 90% of…

  10. Top-Down Influence in Young Children's Linguistic Ambiguity Resolution

    ERIC Educational Resources Information Center

    Rabagliati, Hugh; Pylkkanen, Liina; Marcus, Gary F.

    2013-01-01

    Language is rife with ambiguity. Do children and adults meet this challenge in similar ways? Recent work suggests that while adults resolve syntactic ambiguities by integrating a variety of cues, children are less sensitive to top-down evidence. We test whether this top-down insensitivity is specific to syntax or a general feature of children's…

  11. 7. TIP TOP MINE. DETAIL OF RAIL TRACKS LEADING INTO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. TIP TOP MINE. DETAIL OF RAIL TRACKS LEADING INTO HOUSE TOWARDS COLLAPSED REAR OF BUILDING. DOOR HINGES VISIBLE AND CEILING SUPPORT IN ID-31-C-10 VISIBLE. - Florida Mountain Mining Sites, Tip Top Mine, West face Florida Mountain, approximately 150 feet below summit, Silver City, Owyhee County, ID

  12. 3. ONTARIO MINE. ADIT ENTRANCE WITH TIN ROOF. TIP TOP ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. ONTARIO MINE. ADIT ENTRANCE WITH TIN ROOF. TIP TOP IS LOCATED IN LINE WITH 'Y' BRANCH AND THE TAILING PILE FOR TIP TOP IS VISIBLE JUST TO RIGHT OF IT. CAMERA POINTED SOUTH-SOUTHEAST. - Florida Mountain Mining Sites, Ontario Mine, Northwest side of Florida Mountain, Silver City, Owyhee County, ID

  13. 4. TIP TOP MINE. VIEW FROM WASTE ROCK ABOVE WITH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. TIP TOP MINE. VIEW FROM WASTE ROCK ABOVE WITH WOOD REMAINS OF POSSIBLE ADIT IN LOWER LEFT. CAMERA POINTED WEST. - Florida Mountain Mining Sites, Tip Top Mine, West face Florida Mountain, approximately 150 feet below summit, Silver City, Owyhee County, ID

  14. 9. TIP TOP MINE. INTERIOR VIEW OF LIVING QUARTER WITH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. TIP TOP MINE. INTERIOR VIEW OF LIVING QUARTER WITH STOVE PIPE AND DRAIN SETUP VISIBLE. CAMERA IS POINTED WEST. - Florida Mountain Mining Sites, Tip Top Mine, West face Florida Mountain, approximately 150 feet below summit, Silver City, Owyhee County, ID

  15. Race to Top Promises Come Home to Roost

    ERIC Educational Resources Information Center

    McNeil, Michele

    2012-01-01

    Grant recipients risk losing millions of dollars in Race to the Top money if they fail to live up to their promises, federal education officials make clear. By threatening to revoke Hawaii's $75 million Race to the Top award for failing to make "adequate progress" on key milestones of its education reform plan, U.S. Secretary of Education Arne…

  16. Vertical variation of ice particle size in convective cloud tops

    NASA Astrophysics Data System (ADS)

    van Diedenhoven, Bastiaan; Fridlind, Ann M.; Cairns, Brian; Ackerman, Andrew S.; Yorks, John E.

    2016-05-01

    A novel technique is used to estimate derivatives of ice effective radius with respect to height near convective cloud tops (dre/dz) from airborne shortwave reflectance measurements and lidar. Values of dre/dz are about -6 μm/km for cloud tops below the homogeneous freezing level, increasing to near 0 μm/km above the estimated level of neutral buoyancy. Retrieved dre/dz compares well with previously documented remote sensing and in situ estimates. Effective radii decrease with increasing cloud top height, while cloud top extinction increases. This is consistent with weaker size sorting in high, dense cloud tops above the level of neutral buoyancy where fewer large particles are present and with stronger size sorting in lower cloud tops that are less dense. The results also confirm that cloud top trends of effective radius can generally be used as surrogates for trends with height within convective cloud tops. These results provide valuable observational targets for model evaluation.

  17. 27. VIEW FROM TOP OF SPILLWAY GATE STRUCTURE, LOOKING ACROSS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    27. VIEW FROM TOP OF SPILLWAY GATE STRUCTURE, LOOKING ACROSS TOP OF DAM TOWARDS LEFT ABUTMENT. NOTE PUMPCRETE PIPELINE OF CATWALK WHICH IS USED TO DELIVER CONCRETE TO INCOMPLETE ARCHES ON LEFT SIDE. January 1, 1939 - Bartlett Dam, Verde River, Phoenix, Maricopa County, AZ

  18. Vertical Variation of Ice Particle Size in Convective Cloud Tops

    NASA Technical Reports Server (NTRS)

    Van Diedenhoven, Bastiaan; Fridlind, Ann M.; Cairns, Brian; Ackerman, Andrew S.; Yorks, John E.

    2016-01-01

    A novel technique is used to estimate derivatives of ice effective radius with respect to height near convective cloud tops (dr(sub e)/dz) from airborne shortwave reflectance measurements and lidar. Values of dr(sub e)/dz are about -6 micrometer/km for cloud tops below the homogeneous freezing level, increasing to near 0 micrometer/km above the estimated level of neutral buoyancy. Retrieved dr(sub e)/dz compares well with previously documented remote sensing and in situ estimates. Effective radii decrease with increasing cloud top height, while cloud top extinction increases. This is consistent with weaker size sorting in high, dense cloud tops above the level of neutral buoyancy where fewer large particles are present and with stronger size sorting in lower cloud tops that are less dense. The results also confirm that cloud top trends of effective radius can generally be used as surrogates for trends with height within convective cloud tops. These results provide valuable observational targets for model evaluation.

  19. Higher Education's Top-Ten Strategic Technologies for 2014

    ERIC Educational Resources Information Center

    Grajek, Susan

    2014-01-01

    The annual "EDUCAUSE" top-ten IT issues in higher education receives a great deal of interest and attention. IT and higher education leaders use it to calibrate their IT-related activities and inform their strategic planning. This year "EDUCAUSE" is introducing a complementary list: the top-ten strategic technologies in higher…

  20. Building America Top Innovations 2012: Advanced Framing Systems and Packages

    SciTech Connect

    none,

    2013-01-01

    This Building America Top Innovations profile describes Building America research showing advanced 2x6, 24-inch on-center framing, single top plates, open headers, and 2-stud corners reduced board feet of lumber by more than 1,000 feet, cut energy use by 13%, and cut material and labor costs by more than $1,000 on a typical home.

  1. 76 FR 56183 - Race to the Top Fund Phase 3

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-12

    ... criteria, published in the Federal Register on November 18, 2009 (74 FR 59688) apply to the Race to the Top... the Top Fund published in the Federal Register on November 18, 2009 (74 FR 59688)) Final Requirements... Program published in the Federal Register on November 12, 2009 (74 FR 58436).) (c) At the time the...

  2. 75 FR 4463 - Race to the Top Fund

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-27

    ... this section. SUPPLEMENTARY INFORMATION: Correction Appendix B to the November 18 Final Rule (74 FR... Education 34 CFR Subtitle B, Chapter II Race to the Top Fund; Final Rule and Notice #0;#0;Federal Register... 34 CFR Subtitle B, Chapter II RIN 1810-AB07 Race to the Top Fund AGENCY: Department of...

  3. 75 FR 30007 - Race to the Top Fund Assessment Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-28

    ..., 2010, the Department of Education published in the Federal Register (75 FR 18171) a notice inviting applications for new awards for FY 2010 (NIA) for the Race to the Top Fund Assessment Program. This notice... Overview Information Race to the Top Fund Assessment Program Catalog of Federal Domestic Assistance...

  4. 78 FR 60268 - Race to the Top-District

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-01

    ... Affected Counties. All other information in the August 6, 2013, Notice Inviting Applications (78 FR 48006... to the Top--District AGENCY: Office of the Deputy Secretary, Department of Education. ACTION: Notice extending the deadline of the fiscal year (FY) 2013 Race to the Top--District competition for certain...

  5. 75 FR 4466 - Race to the Top Fund

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-27

    ... published a notice in the Federal Register (74 FR 59836) inviting applications for new awards for FY 2010 for the Race to the Top Fund (NIA). Included as Appendix B to the November 18 NIA was the Scoring... to the Top Fund AGENCY: Department of Education. ACTION: Notice inviting applications for new...

  6. Table Top Tennis: A Vehicle for Teaching Sportspersonship and Responsibility

    ERIC Educational Resources Information Center

    Schwager, Susan; Stylianou, Michalis

    2012-01-01

    Table top tennis is a game that can be played in the classroom or lunchroom when the gymnasium is unavailable. It is a good activity for developing sportspersonship and responsibility in students in grades four and up. This article provides a description of table top tennis, including basic rules and strategies; an explanation of how it can…

  7. Selective Comprehensives: The Social Composition of Top Comprehensive Schools

    ERIC Educational Resources Information Center

    Sutton Trust, 2013

    2013-01-01

    This study looks at publicly available data on the proportion of pupils eligible and claiming for free school meals (FSM) in the top 500 comprehensive state schools and at how representative they are of their localities and of their school type. We have looked at the top 500 when measured by five good GCSEs including English and Maths and at the…

  8. Improved micromorph tandem cell performance through enhanced top cell currents

    SciTech Connect

    Platz, R.; Vaucher, N.P.; Fischer, D.; Meier, J.; Shah, A.

    1997-12-31

    Two approaches to increasing the current in the amorphous silicon top cell of an amorphous silicon/microcrystalline silicon (a-Si:H/{micro}c-Si:H) tandem cell are presented. The goal is to raise the stabilized efficiency of such cells. The deposition of the amorphous top cell at higher than standard substrate temperature is shown to reduce the optical gap of the i-layer and to increase the current which is generated with a given i-layer thickness. Furthermore, a selectively reflecting ZnO interface layer between the component cells is presented as a viable tool for enhancing the current generation in the top cell by selective reflection of light. The authors present a micromorph tandem cell containing the amorphous top cell deposited at high substrate temperature, and additionally the ZnO mirror layer. A top cell thickness of 150 nm is shown to be sufficient to provide a current density of 13mA/cm{sup 2} in the top cell. Finally, the influence of such thin top cells on the stabilized efficiency of the tandem cell is investigated by experiment and by means of semi-empirical modeling. Model and experiment confirm that such reduced-gap top cells, together with current enhancement due to the mirror layer, have a high potential for improving the stabilized efficiency of micromorph tandem cells.

  9. 8. Comparison of construction of bottom and top chords and ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Comparison of construction of bottom and top chords and pin connections, bottom chord second panel point, top chords showing third panel point. - Bridge No. 2.4, Spanning Boiling Fork Creek at Railroad Milepost JC-2.4, Decherd, Franklin County, TN

  10. Safety Hazards Posed by Ceramic-Top Hotplates.

    ERIC Educational Resources Information Center

    De Forest, Peter; And Others

    1988-01-01

    Describes a laboratory explosion involving 30 percent hydrogen peroxide being heated on a ceramic-top hotplate. Gives three safety suggestions: peroxides should be treated as potential explosion hazards; alternatives to the ceramic-top hotplate for these reactions should be considered; and lab workers should be prepared for the worst possible…

  11. QCD and Top-Quark Results from the Tevatron

    SciTech Connect

    Zielinski, Marek; /Rochester U.

    2006-10-01

    Selected recent QCD and top-quark results from the Tevatron are reviewed, aiming to illustrate progression from basic studies of QCD processes to verification of perturbative calculations and Monte Carlo simulation tools, and to their applications in more novel and complex cases, like top-quark studies and searches for new physics.

  12. The Relationship between Top Management Communication and Organizational Effectiveness.

    ERIC Educational Resources Information Center

    Pincus, J. David; Rayfield, Robert E.

    A study examined the notion that employees' perceptions of communication between an organization's top managers and its employees influences certain key organizational variables in differing and predictable ways. Specifically, the study investigated whether employees' perceptions of top management communication were related to their job…

  13. 26. DETAIL OF STRUCTURAL COLLAPSE OF TOP FLOOR OF MILL, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    26. DETAIL OF STRUCTURAL COLLAPSE OF TOP FLOOR OF MILL, ABOVE ORE BIN, LOOKING WEST FROM TOP OF STAIRWAY IN CA-290-25. THE PIPE AT CENTER WAS USED TO SPREAD CRUSHED ORE COMING FROM THE JAW CRUSHER EVENLY TO ALL AREA OF THE ORE BIN BELOW. - Skidoo Mine, Park Route 38 (Skidoo Road), Death Valley Junction, Inyo County, CA

  14. SOUTHWEST VIEW OF FOUNDRY FROM TOP OF GREY IRON CUPOLA ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    SOUTHWEST VIEW OF FOUNDRY FROM TOP OF GREY IRON CUPOLA SHOWING OPENED TOP OF CUPOLA WITH EMISSION RECOVERY DUCT COMING OFF. TO THE RIGHT IS THE STORAGE AND SHIPPING BUILDING. - Stockham Pipe & Fittings Company, 4000 Tenth Avenue North, Birmingham, Jefferson County, AL

  15. Top Ten List for Choosing to Become a Mentor

    ERIC Educational Resources Information Center

    Bowden, Shelly

    2004-01-01

    In true David Letterman style, this article presents a Top Ten List for why and how it's important to get to know the beginning teacher next door or just down the hall and listen for call signals. What follows is the Top Ten List for becoming a mentor: (1) establish reciprocal collaboration through trust; (2) offer a shoulder of support; (3) share…

  16. BB: Half Section; Top of Engine; Valve Gear Detail; CC: ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    B-B: Half Section; Top of Engine; Valve Gear Detail; C-C: Top of Condenser; D-D: Condenser Interior; Air Pump Piston; Air Pump Lever; Water Pump - Steamboat COLUMBUS, Submerged south-southeast of Point Lookout, Scotland, St. Mary's County, MD

  17. Molecular Electronics

    NASA Astrophysics Data System (ADS)

    Petty, Michael

    The prospects of using organic materials in electronics and optoelectronics applications have attracted scientists and technologists since the 1970s. This field has become known as molecular electronics. Some successes have already been achieved, for example the liquid-crystal display. Other products such as organic light-emitting displays, chemical sensors and plastic transistors are developing fast. There is also a keen interest in exploiting technologies at the molecular scale that might eventually replace silicon devices. This chapter provides some of the background physics and chemistry to the interdisciplinary subject of molecular electronics. A review of some of the possible application areas for organic materials is presented and some speculation is provided regarding future directions.

  18. Measurements of the Top Quark at the Tevatron Collider

    SciTech Connect

    Cerrito, Lucio

    2007-01-01

    The authors present recent preliminary measurements of the top-antitop pair production cross section and determinations of the top quark pole mass, performed using the data collected by the CDF and D0 Collaborations at the Tevatron Collider. In the lepton plus jets final state, with semileptonic B decay, the pair production cross section has now been measured at CDF using {approx} 760 pb{sup -1} of proton-antiproton collisions at a center-of-mass energy of {radical}s = 1.96 TeV. A measurement of the production cross section has also been made with {approx} 1 fb{sup -1} of data in the all-jets final state by the CDF Collaboration. The mass of the top quark has now been measured using {approx} 1 fb{sup -1} of collision data using all decay channels of the top quark pair, yielding the most precise measurements of the top mass to date.

  19. Signatures of top flavour-changing dark matter

    NASA Astrophysics Data System (ADS)

    D'Hondt, Jorgen; Mariotti, Alberto; Mawatari, Kentarou; Moortgat, Seth; Tziveloglou, Pantelis; Van Onsem, Gerrit

    2016-03-01

    We develop the phenomenology of scenarios in which a dark matter candidate interacts with a top quark through flavour-changing couplings, employing a simplified dark matter model with an s-channel vector-like mediator. We study in detail the top-charm flavour-changing interaction, by investigating the single top plus large missing energy signature at the LHC as well as constraints from the relic density and direct and indirect dark matter detection experiments. We present strategies to distinguish between the top-charm and top-up flavour-changing models by taking advantage of the lepton charge asymmetry as well as by using charm-tagging techniques on an extra jet. We also show the complementarity between the LHC and canonical dark matter experiments in exploring the viable parameter space of the models.

  20. Measurements of the top quark mass at the Tevatron

    SciTech Connect

    Brandt, Oleg; /Gottingen U., II. Phys. Inst.

    2012-04-01

    The mass of the top quark (m{sub top}) is a fundamental parameter of the standard model (SM). Currently, its most precise measurements are performed by the CDF and D0 collaborations at the Fermilab Tevatron p{bar p} collider at a centre-of-mass energy of {radical}s = 1.96 TeV. We review the most recent of those measurements, performed on data samples of up to 8.7 fb{sup -1} of integrated luminosity. The Tevatron combination using up to 5.8 fb{sup -1} of data results in a preliminary world average top quark mass of m{sub top} = 173.2 {+-} 0.9 GeV. This corresponds to a relative precision of about 0.54%. We conclude with an outlook of anticipated precision the final measurement of m{sub top} at the Tevatron.