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1

Find Duplicates among the PubMed, EMBASE, and Cochrane Library Databases in Systematic Review  

PubMed Central

Background Finding duplicates is an important phase of systematic review. However, no consensus regarding the methods to find duplicates has been provided. This study aims to describe a pragmatic strategy of combining auto- and hand-searching duplicates in systematic review and to evaluate the prevalence and characteristics of duplicates. Methods and Findings Literatures regarding portal vein thrombosis (PVT) and Budd-Chiari syndrome (BCS) were searched by the PubMed, EMBASE, and Cochrane library databases. Duplicates included one index paper and one or more redundant papers. They were divided into type-I (duplicates among different databases) and type-II (duplicate publications in different journals/issues) duplicates. For type-I duplicates, reference items were further compared between index and redundant papers. Of 10936 papers regarding PVT, 2399 and 1307 were identified as auto- and hand-searched duplicates, respectively. The prevalence of auto- and hand-searched redundant papers was 11.0% (1201/10936) and 6.1% (665/10936), respectively. They included 3431 type-I and 275 type-II duplicates. Of 11403 papers regarding BCS, 3275 and 2064 were identified as auto- and hand-searched duplicates, respectively. The prevalence of auto- and hand-searched redundant papers was 14.4% (1640/11403) and 9.1% (1039/11403), respectively. They included 5053 type-I and 286 type-II duplicates. Most of type-I duplicates were identified by auto-searching method (69.5%, 2385/3431 in PVT literatures; 64.6%, 3263/5053 in BCS literatures). Nearly all type-II duplicates were identified by hand-searching method (94.9%, 261/275 in PVT literatures; 95.8%, 274/286 in BCS literatures). Compared with those identified by auto-searching method, type-I duplicates identified by hand-searching method had a significantly higher prevalence of wrong items (47/2385 versus 498/1046, p<0.0001 in PVT literatures; 30/3263 versus 778/1790, p<0.0001 in BCS literatures). Most of wrong items originated from EMBASE database. Conclusion Given the inadequacy of a single strategy of auto-searching method, a combined strategy of auto- and hand-searching methods should be employed to find duplicates in systematic review. PMID:23977157

Wang, Juan; Han, Guohong; Fan, Daiming

2013-01-01

2

Dialysis Search Filters for PubMed, Ovid MEDLINE, and Embase Databases  

PubMed Central

Summary Background and objectives Physicians frequently search bibliographic databases, such as MEDLINE via PubMed, for best evidence for patient care. The objective of this study was to develop and test search filters to help physicians efficiently retrieve literature related to dialysis (hemodialysis or peritoneal dialysis) from all other articles indexed in PubMed, Ovid MEDLINE, and Embase. Design, setting, participants, & measurements A diagnostic test assessment framework was used to develop and test robust dialysis filters. The reference standard was a manual review of the full texts of 22,992 articles from 39 journals to determine whether each article contained dialysis information. Next, 1,623,728 unique search filters were developed, and their ability to retrieve relevant articles was evaluated. Results The high-performance dialysis filters consisted of up to 65 search terms in combination. These terms included the words “dialy” (truncated), “uremic,” “catheters,” and “renal transplant wait list.” These filters reached peak sensitivities of 98.6% and specificities of 98.5%. The filters’ performance remained robust in an independent validation subset of articles. Conclusions These empirically derived and validated high-performance search filters should enable physicians to effectively retrieve dialysis information from PubMed, Ovid MEDLINE, and Embase. PMID:22917701

Iansavichus, Arthur V.; Haynes, R. Brian; Lee, Christopher W.C.; Wilczynski, Nancy L.; McKibbon, Ann; Shariff, Salimah Z.; Blake, Peter G.; Lindsay, Robert M.

2012-01-01

3

Retrieval comparison of EndNote to search MEDLINE (Ovid and PubMed) versus searching them directly.  

PubMed

Using EndNote version 7.0, the authors tested the search capabilities of the EndNote search engine for retrieving citations from MEDLINE for importation into EndNote, a citation management software package. Ovid MEDLINE and PubMed were selected for the comparison. Several searches were performed on Ovid MEDLINE and PubMed using EndNote as the search engine, and the same searches were run on both Ovid and PubMed directly. Findings indicate that it is preferable to search MEDLINE directly rather than using EndNote. The publishers of EndNote do warn its users about the limitations of their product as a search engine when searching external databases. In this article, the limitations of EndNote as a search engine for searching MEDLINE were explored as related to MeSH, non-MeSH, citation verification, and author searching. PMID:15364649

Gall, Carole; Brahmi, Frances A

2004-01-01

4

Glomerular disease search filters for Pubmed, Ovid Medline, and Embase: a development and validation study  

PubMed Central

Background Tools to enhance physician searches of Medline and other bibliographic databases have potential to improve the application of new knowledge in patient care. This is particularly true for articles about glomerular disease, which are published across multiple disciplines and are often difficult to track down. Our objective was to develop and test search filters for PubMed, Ovid Medline, and Embase that allow physicians to search within a subset of the database to retrieve articles relevant to glomerular disease. Methods We used a diagnostic test assessment framework with development and validation phases. We read a total of 22,992 full text articles for relevance and assigned them to the development or validation set to define the reference standard. We then used combinations of search terms to develop 997,298 unique glomerular disease filters. Outcome measures for each filter included sensitivity, specificity, precision, and accuracy. We selected optimal sensitive and specific search filters for each database and applied them to the validation set to test performance. Results High performance filters achieved at least 93.8% sensitivity and specificity in the development set. Filters optimized for sensitivity reached at least 96.7% sensitivity and filters optimized for specificity reached at least 98.4% specificity. Performance of these filters was consistent in the validation set and similar among all three databases. Conclusions PubMed, Ovid Medline, and Embase can be filtered for articles relevant to glomerular disease in a reliable manner. These filters can now be used to facilitate physician searching. PMID:22672435

2012-01-01

5

PubMed Interact: an interactive search application for MEDLINE/PubMed.  

PubMed

Online search and retrieval systems are important resources for medical literature research. Progressive Web 2.0 technologies provide opportunities to improve search strategies and user experience. Using PHP, Document Object Model (DOM) manipulation and Asynchronous JavaScript and XML (Ajax), PubMed Interact allows greater functionality so users can refine search parameters with ease and interact with the search results to retrieve and display relevant information and related articles. PMID:17238658

Muin, Michael; Fontelo, Paul; Ackerman, Michael

2006-01-01

6

NCBI: PubMed  

NSDL National Science Digital Library

PubMed comprises more than 21 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.

NCBI (National Center for Biotechnology Information)

2012-01-20

7

PubMed  

NSDL National Science Digital Library

This site, hosted by PubMed, is a service of the National Library of Medicine. The searchable site includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources.

Medicine, National L.

8

PubMed contains all of MEDLINE (1966-present), OLDMEDLINE (1946-1965), PubMed in-process records (new citations not yet fully indexed) and some additional non-MEDLINE citations. It is the primary database for researchers in the fields of biochemistry, mol  

E-print Network

BASIC SEARCH TECHNIQUES PubMed searching is easy. Just enter your search terms in the search box to additional searching options. Keyword Searching Enter one or more keywords (e.g., molecular motors) in the search box and click Search. PubMed automatically combines (ANDs) significant terms together using

California at Berkeley, University of

9

Social Networks in Education of Health Professionals in Bosnia and Herzegovina - the Role of Pubmed/Medline in Improvement of Medical Sciences  

PubMed Central

Introduction: Social network is a social structure made up of individuals and organizations that represent “nodes”, and they are associated with one or more types of interdependency; such as: friendship, common interests, work, knowledge, prestige and many other interests. Beginning with the late twentieth and early twenty-first century, the Internet was a significant additional tool in the education of teenagers. Later, it takes more and more significant role in educating students and professionals. Goal: The aim of this paper is to investigate, to what extent and how effectively the Internet is used today. In addition, more specifically, this paper will research the implications of the well-known social networks in education of students and health professionals in Bosnia and Herzegovina (B&H). Material and methods: We compared the ratio of using Medline, as the largest biomedical data base system for spreading medical information, as basics for health education at biomedical faculties at five universities in B&H. Results and discussion: According to data from the CRA (i.e. Communications Regulatory Agency) in B&H, in 2010, there were 522,364 internet access accounts, with about 2 million Internet users, representing about 52% of the total population. The Internet users’ preference is dominated by the users of fast broadband access (e.g. xDSL) with 42.8%, and elsewhere, still with dialup access, with 25.2%. The results showed that only 11.6% of professors use Facebook type of social network, 49.3% of them have a profile on BiomedExperts scientific social network and 79% have available articles in the largest biomedical literature database MEDLINE. Students are also frequent users of general social networks and educational clips from You Tube, which they prefer to utilize considerably more than the other types of professionals. Students rarely use the facilities of professional social networks, because they contain mainly data and information needed for further, postgraduate professional education. In our research, we analized cited published papers in the journal Medical Archives, the oldest medical journal in B&H (established in 1947) of randomly included 151 full and part time professors, authors from five medical faculties in B&H and B&H authors who currently work in the EU and USA.. ANOVA showed that there was no significant difference in the number of articles published between the Universities in Bosnia, but there was significant difference in the number of articles published on MEDLINE, between all faculties in B&H and a group of scientists who work around the world. Students’ tests showed that there was a statistically significant difference in the average number of papers published on Medline, between groups of part-time and full time professors. However, there were no statistically significant differences, between the professors for preclinical and clinical subjects. Conclusion: In B&H there are decent conditions for the use of online social networks in the education of health professionals. While students enthusiastically embraced these opportunities, this is not so much a case with health care professionals in practice; while scientific health care workers have not shown greater interest in the use of social networks, both for purposes of scientific research and in terms of self-education and training of students. There is much more use of the advantages offered by online social networks, both in education and in support of the scientific research. PMID:23408513

Masic, Izet; Sivic, Suad

2011-01-01

10

Cancer Literature in PubMed  

Cancer.gov

PubMed, a service of the National Library of Medicine, provides access to over 12 million MEDLINE literature citations dating back to the mid-1960s. PubMed also includes links to many full-text articles at journal Web sites as well as links to related Web resources.

11

PubMed Tutorial  

NSDL National Science Digital Library

PubMed Tutorial is a "web-based learning program that will show you how to search PubMed, the National Library of Medicine's journal literature search system." Clear, detailed explanations and helpful animations guide users in making the most of PubMed's many features. The level of detail in this tutorial is amazing, yet not overwhelming (thanks again to animations and demonstrations that replicate the PubMed user interface). A final review section offers a number of practice exercises.

12

Methods to improve recruitment to randomised controlled trials: Cochrane systematic review and meta-analysis  

PubMed Central

This review is an abridged version of a Cochrane Review previously published in the Cochrane Database of Systematic Reviews 2010, Issue 4, Art. No.: MR000013 DOI: 10.1002/14651858.MR000013.pub5 (see www.thecochranelibrary.com for information). Cochrane Reviews are regularly updated as new evidence emerges and in response to feedback, and Cochrane Database of Systematic Reviews should be consulted for the most recent version of the review. Objective To identify interventions designed to improve recruitment to randomised controlled trials, and to quantify their effect on trial participation. Design Systematic review. Data sources The Cochrane Methodology Review Group Specialised Register in the Cochrane Library, MEDLINE, EMBASE, ERIC, Science Citation Index, Social Sciences Citation Index, C2-SPECTR, the National Research Register and PubMed. Most searches were undertaken up to 2010; no language restrictions were applied. Study selection Randomised and quasi-randomised controlled trials, including those recruiting to hypothetical studies. Studies on retention strategies, examining ways to increase questionnaire response or evaluating the use of incentives for clinicians were excluded. The study population included any potential trial participant (eg, patient, clinician and member of the public), or individual or group of individuals responsible for trial recruitment (eg, clinicians, researchers and recruitment sites). Two authors independently screened identified studies for eligibility. Results 45 trials with over 43?000 participants were included. Some interventions were effective in increasing recruitment: telephone reminders to non-respondents (risk ratio (RR) 1.66, 95% CI 1.03 to 2.46; two studies, 1058 participants), use of opt-out rather than opt-in procedures for contacting potential participants (RR 1.39, 95% CI 1.06 to 1.84; one study, 152 participants) and open designs where participants know which treatment they are receiving in the trial (RR 1.22, 95% CI 1.09 to 1.36; two studies, 4833 participants). However, the effect of many other strategies is less clear, including the use of video to provide trial information and interventions aimed at recruiters. Conclusions There are promising strategies for increasing recruitment to trials, but some methods, such as open-trial designs and opt-out strategies, must be considered carefully as their use may also present methodological or ethical challenges. Questions remain as to the applicability of results originating from hypothetical trials, including those relating to the use of monetary incentives, and there is a clear knowledge gap with regard to effective strategies aimed at recruiters. PMID:23396504

Treweek, Shaun; Lockhart, Pauline; Pitkethly, Marie; Cook, Jonathan A; Kjeldstr?m, Monica; Johansen, Marit; Taskila, Taina K; Sullivan, Frank M; Wilson, Sue; Jackson, Catherine; Jones, Ritu; Mitchell, Elizabeth D

2013-01-01

13

Automatic Export of PubMed Citations to EndNote.  

PubMed

The export of MEDLINE references to EndNote can be accomplished in various ways. Unlike Ovid MEDLINE, PubMed does not have a direct export feature to EndNote. Until recently, PubMed references had to be saved as a text file to import into EndNote. Now, the automatic export of PubMed references can be done using Internet Explorer (IE) or Mozilla Firefox Web browsers. The development and teaching of seamless citation management is a value-added service to health professionals. PMID:20432138

London, Sue; Gurdal, Osman; Gall, Carole

2010-04-01

14

Home based versus centre based cardiac rehabilitation: Cochrane systematic review and meta-analysis  

Microsoft Academic Search

Objective To compare the effect of home based and supervised centre based cardiac rehabilitation on mortality and morbidity, health related quality of life, and modifiable cardiac risk factors in patients with coronary heart disease.Design Systematic review.Data sources Cochrane Central Register of Controlled Trials (CENTRAL) in the Cochrane Library, Medline, Embase, CINAHL, and PsycINFO, without language restriction, searched from 2001 to

Hasnain M Dalal; Anna Zawada; Kate Jolly; Tiffany Moxham; Rod S Taylor

2010-01-01

15

PubMed Help PubMed comprises over 23 million citations for biomedical literature from MEDLINE, life  

E-print Network

the key concepts for your search. 2 Enter the terms (or key concepts) in the search box. 3 Suggestions by Bonnie W. Ramsey about gene therapy for cystic fibrosis enter the following search terms into the search will display as you type your search terms. Click Turn off to temporarily disable the autocomplete feature. 4

Levin, Judith G.

16

Fifteenth biannual report of the Cochrane Haematological Malignancies Group--focus on non-Hodgkin's lymphoma.  

PubMed

This fifteenth biannual report of the Cochrane Haematological Malignancies Group (CHMG) highlights recently published randomized controlled trials (RCTs) in the field of hemato-oncology, covering the publication period from October 2011 to May 2012. Implications for clinical practice and methodological aspects are the main principles for selecting trials for this report. Studies were identified by electronic search of MEDLINE using a broad search filter that covers all topics in hemato-oncology combined with a highly sensitive search filter for randomized trials (Cochrane Handbook for Systematic Reviews of Interventions). PMID:23852951

Rancea, Michaela; Will, Andrea; Borchmann, Peter; Monsef, Ina; Engert, Andreas; Skoetz, Nicole

2013-08-01

17

The absolute spectrophotometric catalog by Anita Cochran  

NASA Astrophysics Data System (ADS)

The absolute spectrophotometric catalog by Anita Cochran is presented in a machine-readable form. The catalog systematizes observations acquired at the McDonald Observatory in 1977-1978. The data are compared with other sources, in particular, the calculated broadband stellar magnitudes are compared with photometric observations by other authors, to show that the observational data given in the catalog are reliable and suitable for a variety of applications. Observations of variable stars of different types make Cochran's catalog especially valuable.

Burnashev, V. I.; Burnasheva, B. A.; Ruban, E. V.; Hagen-Torn, E. I.

2014-06-01

18

Medicinal Herbs for Hepatitis C Virus Infection: A Cochrane Hepatobiliary Systematic Review of Randomized Trials  

Microsoft Academic Search

OBJECTIVE:The aim of this study was to assess beneficial and harmful effects of medicinal herbs for hepatitis C virus (HCV) infection.METHODS:The databases of the Cochrane Collaboration, MEDLINE, EMBASE, and BIOSIS were searched combined with manual searches of five Chinese and one Japanese journals. We included randomized trials comparing medicinal herbs with placebo, no intervention, nonspecific treatment, other herbs, or interferon

Jianping Liu; Eric Manheimer; Kiichiro Tsutani; Christian Gluud

2003-01-01

19

About CAM on PubMed  

MedlinePLUS

... literature search will be automatically limited to the complementary and alternative medicine (CAM) subset of PubMed. Your searches are free. ... USA.gov—Government Made Easy National Center for Complementary and Alternative Medicine (NCCAM), 9000 Rockville Pike, Bethesda, Maryland 20892

20

MEDLINE (MEDLARS ONLINE)  

EPA Science Inventory

MEDLINE (MEDlars onLINE) is the National Library of Medicines (NLM) premier bibliographic database covering the fields of medicine, nursing, dentistry, veterinary medicine, the health care system, and the preclinical sciences. It contains bibliographic citations (e.g., authors, ...

21

Acta Informatica Medica Is Indexed In Pubmed And Archived In Pubmed Central  

PubMed Central

Acta Informatica Medica journal has been accepted for archiving in PubMed Central from 2011 onward. The journal started in 1993 as the official journal of the Society for Medical Informatics of Bosnia and Herzegovina. During the last 3 years, Acta Informatica Medica has een included in almost all prestigious online databases, including PubMed, Scopus and EMBASE. The 20th volume of the journal is fully international, with papers from 18 countries. PMID:23572852

Masic, Izet

2013-01-01

22

SPELLING CORRECTION IN THE PUBMED SEARCH ENGINE.  

PubMed

It is known that users of internet search engines often enter queries with misspellings in one or more search terms. Several web search engines make suggestions for correcting misspelled words, but the methods used are proprietary and unpublished to our knowledge. Here we describe the methodology we have developed to perform spelling correction for the PubMed search engine. Our approach is based on the noisy channel model for spelling correction and makes use of statistics harvested from user logs to estimate the probabilities of different types of edits that lead to misspellings. The unique problems encountered in correcting search engine queries are discussed and our solutions are outlined. PMID:18080004

Wilbur, W John; Kim, Won; Xie, Natalie

2006-11-01

23

Research, practice and the Cochrane Collaboration.  

PubMed Central

The Cochrane Collaboration coordinates the efforts of health care professionals and researchers around the world to prepare, maintain and disseminate systematic reviews of health care research. In carrying out the first two tasks the collaboration employs a rigorous method for analysing the findings of randomized controlled trials; this method was developed in the 1980s and has undergone continual improvement since then. The collaborators believe their work will consolidate and make available the accumulated results of sound research assessing the effectiveness of health care interventions and thus steer health care professionals and consumers toward the right treatments and help guide research into new therapies. Since the collaboration began, in 1993, Cochrane centres have been set up in the British Isles, Canada, Denmark, Italy, the Netherlands and the United States, and many new Cochrane review groups have been registered. Canadian scientists have played an important role in the collaboration. They have prepared and maintained systematic reviews, hosted the collaboration's second annual colloquium and are currently in the vanguard of efforts to facilitate the dissemination of collaboration documents. Although the collaboration uses new modes of communication it has not abandoned traditional ones. Nor has it underestimated the work that remains to be done to bring review findings to the attention of health care providers. Early indications suggest, however, that the collaboration's basic message about the importance of evidence-based practice is getting through. Images p885-a PMID:7697581

Robinson, A

1995-01-01

24

MedlinePlus FAQ: Mobile Version of MedlinePlus  

MedlinePLUS

... Videos & Cool Tools ESPAÑOL Question: Is there a mobile version of MedlinePlus? To use the sharing features ... please enable JavaScript. Answer: Yes, there is a mobile version of MedlinePlus. You do not need a ...

25

Studying PubMed usages in the field for complex problem solving: Implications for tool design  

PubMed Central

Many recent studies on MEDLINE-based information seeking have shed light on scientists’ behaviors and associated tool innovations that may improve efficiency and effectiveness. Few if any studies, however, examine scientists’ problem-solving uses of PubMed in actual contexts of work and corresponding needs for better tool support. Addressing this gap, we conducted a field study of novice scientists (14 upper level undergraduate majors in molecular biology) as they engaged in a problem solving activity with PubMed in a laboratory setting. Findings reveal many common stages and patterns of information seeking across users as well as variations, especially variations in cognitive search styles. Based on findings, we suggest tool improvements that both confirm and qualify many results found in other recent studies. Our findings highlight the need to use results from context-rich studies to inform decisions in tool design about when to offer improved features to users. PMID:24376375

Song, Jean; Tonks, Jennifer Steiner; Meng, Fan; Xuan, Weijian; Ameziane, Rafiqa

2012-01-01

26

Meta-analysis and The Cochrane Collaboration: 20 years of the Cochrane Statistical Methods Group  

PubMed Central

The Statistical Methods Group has played a pivotal role in The Cochrane Collaboration over the past 20 years. The Statistical Methods Group has determined the direction of statistical methods used within Cochrane reviews, developed guidance for these methods, provided training, and continued to discuss and consider new and controversial issues in meta-analysis. The contribution of Statistical Methods Group members to the meta-analysis literature has been extensive and has helped to shape the wider meta-analysis landscape. In this paper, marking the 20th anniversary of The Cochrane Collaboration, we reflect on the history of the Statistical Methods Group, beginning in 1993 with the identification of aspects of statistical synthesis for which consensus was lacking about the best approach. We highlight some landmark methodological developments that Statistical Methods Group members have contributed to in the field of meta-analysis. We discuss how the Group implements and disseminates statistical methods within The Cochrane Collaboration. Finally, we consider the importance of robust statistical methodology for Cochrane systematic reviews, note research gaps, and reflect on the challenges that the Statistical Methods Group faces in its future direction. PMID:24280020

2013-01-01

27

Meta-analysis and The Cochrane Collaboration: 20 years of the Cochrane Statistical Methods Group.  

PubMed

The Statistical Methods Group has played a pivotal role in The Cochrane Collaboration over the past 20 years. The Statistical Methods Group has determined the direction of statistical methods used within Cochrane reviews, developed guidance for these methods, provided training, and continued to discuss and consider new and controversial issues in meta-analysis. The contribution of Statistical Methods Group members to the meta-analysis literature has been extensive and has helped to shape the wider meta-analysis landscape.In this paper, marking the 20th anniversary of The Cochrane Collaboration, we reflect on the history of the Statistical Methods Group, beginning in 1993 with the identification of aspects of statistical synthesis for which consensus was lacking about the best approach. We highlight some landmark methodological developments that Statistical Methods Group members have contributed to in the field of meta-analysis. We discuss how the Group implements and disseminates statistical methods within The Cochrane Collaboration. Finally, we consider the importance of robust statistical methodology for Cochrane systematic reviews, note research gaps, and reflect on the challenges that the Statistical Methods Group faces in its future direction. PMID:24280020

McKenzie, Joanne E; Salanti, Georgia; Lewis, Steff C; Altman, Douglas G

2013-01-01

28

Feasibility of a Knowledge Translation CME Program: "Courriels Cochrane"  

ERIC Educational Resources Information Center

Introduction: Systematic literature reviews provide best evidence, but are underused by clinicians. Thus, integrating Cochrane reviews into continuing medical education (CME) is challenging. We designed a pilot CME program where summaries of Cochrane reviews ("Courriels Cochrane") were disseminated by e-mail. Program participants automatically…

Pluye, Pierre; Grad, Roland; Granikov, Vera; Theriault, Guylene; Fremont, Pierre; Burnand, Bernard; Mercer, Jay; Marlow, Bernard; Arroll, Bruce; Luconi, Francesca; Legare, France; Labrecque, Michel; Ladouceur, Roger; Bouthillier, France; Sridhar, Soumya Bindiganavile; Moscovici, Jonathan

2012-01-01

29

Exploring MEDLINE Space with Random Indexing and Pathfinder Networks  

PubMed Central

The integration of disparate research domains is a prerequisite for the success of the translational science initiative. MEDLINE abstracts contain content from a broad range of disciplines, presenting an opportunity for the development of methods able to integrate the knowledge they contain. Latent Semantic Analysis (LSA) and related methods learn human-like associations between terms from unannotated text. However, their computational and memory demands limits their ability to address a corpus of this size. Furthermore, visualization methods previously used in conjunction with LSA have limited ability to define the local structure of the associative networks LSA learns. This paper explores these issues by (1) processing the entire MEDLINE corpus using Random Indexing, a variant of LSA, and (2) exploring learned associations using Pathfinder Networks. Meaningful associations are inferred from MEDLINE, including a drug-disease association undetected by PUBMED search. PMID:18999236

Cohen, Trevor

2008-01-01

30

pubmed2ensembl: A Resource for Mining the Biological Literature on Genes  

PubMed Central

Background The last two decades have witnessed a dramatic acceleration in the production of genomic sequence information and publication of biomedical articles. Despite the fact that genome sequence data and publications are two of the most heavily relied-upon sources of information for many biologists, very little effort has been made to systematically integrate data from genomic sequences directly with the biological literature. For a limited number of model organisms dedicated teams manually curate publications about genes; however for species with no such dedicated staff many thousands of articles are never mapped to genes or genomic regions. Methodology/Principal Findings To overcome the lack of integration between genomic data and biological literature, we have developed pubmed2ensembl (http://www.pubmed2ensembl.org), an extension to the BioMart system that links over 2,000,000 articles in PubMed to nearly 150,000 genes in Ensembl from 50 species. We use several sources of curated (e.g., Entrez Gene) and automatically generated (e.g., gene names extracted through text-mining on MEDLINE records) sources of gene-publication links, allowing users to filter and combine different data sources to suit their individual needs for information extraction and biological discovery. In addition to extending the Ensembl BioMart database to include published information on genes, we also implemented a scripting language for automated BioMart construction and a novel BioMart interface that allows text-based queries to be performed against PubMed and PubMed Central documents in conjunction with constraints on genomic features. Finally, we illustrate the potential of pubmed2ensembl through typical use cases that involve integrated queries across the biomedical literature and genomic data. Conclusion/Significance By allowing biologists to find the relevant literature on specific genomic regions or sets of functionally related genes more easily, pubmed2ensembl offers a much-needed genome informatics inspired solution to accessing the ever-increasing biomedical literature. PMID:21980353

Baran, Joachim; Gerner, Martin; Haeussler, Maximilian; Nenadic, Goran; Bergman, Casey M.

2011-01-01

31

Precision and Negative Predictive Value of Links between ClinicalTrials.gov and PubMed  

PubMed Central

One of the goals of translational science is to shorten the time from discovery to clinical use. Clinical trial registries were established to increase transparency in completed and ongoing clinical trials, and they support linking trials with resulting publications. We set out to investigate precision and negative predictive value (NPV) of links between ClinicalTrials.gov (CT.gov) and PubMed. CT.gov has been established to increase transparency in clinical trials and the link to PubMed is crucial for supporting a number of important functions, including ascertaining publication bias. We drew a random sample of trials downloaded from CT.gov and performed manual review of retrieved publications. We characterize two types of links between trials and publications (NCT-link originating from MEDLINE and PMID-link originating from CT.gov).The link precision is different based on type (NCT-link: 100%; PMID-link: 63% to 96%). In trials with no linked publication, we were able to find publications 44% of the time (NPV=56%) by searching PubMed. This low NPV shows that there are potentially numerous publications that should have been formally linked with the trials. Our results indicate that existing trial registry and publisher policies may not be fully enforced. We suggest some automated methods for improving link quality. PMID:23304310

Huser, Vojtech; Cimino, James J.

2012-01-01

32

MedlinePlus: Diets  

NSDL National Science Digital Library

In this section of their website, Medline Plus, a service of the U.S. National Library of Medicine and the National Institutes of Health, tackles the subject of diets. The information is divided up into half a dozen labeled boxes near the top of the page, and includes "Basics", "Research", "Learn More", and "Reference Shelf". Within these sections visitors can find links to information on "Nutrition", "Specific Conditions", "Journal Articles", "Dictionaries/Glossaries", and more. Many of the topics discussed throughout the categories is the safety of certain diets, such as the link "Nutrition for Weight Loss: What You Need to Know About Fad Diets", and "Are Detox Diets Safe?" found under the Teenagers category at the bottom of the page. Visitors interested in participating in clinical trials going on throughout the United States, can check out the links "ClinicalTrials.gov: Diet" and "ClinicalTrials.gov: Diet Therapy" under the category Clinical Trials.

33

Dr. Felix's Free MEDLINE Page  

NSDL National Science Digital Library

If you need to search the National Medical Library's Medline database, Dr. Felix's Free Medline Page is a good place to start. This simple page is a comparison of twenty-eight web based services that offer free access to parts or all of Medline. For each service users can access information about database coverage, registration requirements, usage restrictions, and document delivery. Hypertext links are available from all of the services discussed. Dr. Felix is a quick and convenient way to launch a Medline session that can inform users of the possible limitations of their search right from the start.

Perry, Helga J.

1997-01-01

34

Bibliometric and content analysis of the Cochrane Complementary Medicine Field specialized register of controlled trials  

PubMed Central

Background The identification of eligible controlled trials for systematic reviews of complementary and alternative medicine (CAM) interventions can be difficult. To increase access to these difficult to locate trials, the Cochrane Collaboration Complementary Medicine Field (CAM Field) has established a specialized register of citations of CAM controlled trials. The objective of this study is to describe the sources and characteristics of citations included in the CAM Field specialized register. Methods Between 2006 and 2011, regular searches for citations of CAM trials in MEDLINE and the Cochrane Central Register of Controlled Trials (CENTRAL) were supplemented with contributions of controlled trial citations from international collaborators. The specialized register was ‘frozen’ for analysis in 2011, and frequencies were calculated for publication date, language, journal, presence in MEDLINE, type of intervention, and type of medical condition. Results The CAM Field specialized register increased in size from under 5,000 controlled trial citations in 2006 to 44,840 citations in 2011. Most citations (60%) were from 2000 or later, and the majority (71%) were reported in English; the next most common language was Chinese (23%). The journals with the greatest number of citations were CAM journals published in Chinese and non-CAM nutrition journals published in English. More than one-third of register citations (36%) were not indexed in MEDLINE. The most common CAM intervention type in the register was non-vitamin, non-mineral dietary supplements (e.g., glucosamine, fish oil) (34%), followed by Chinese herbal medicines (e.g., Astragalus membranaceus, Schisandra chinensis) (27%). Conclusions The availability of the CAM Field specialized register presents both opportunities and challenges for CAM systematic reviewers. While the register provides access to thousands of difficult to locate trial citations, many of these trials are of low quality and may overestimate treatment effects. When including these trials in systematic reviews, adequate analysis of their risk of bias is of utmost importance. PMID:23826877

2013-01-01

35

Medline Plus: Herbal Medicine  

NSDL National Science Digital Library

From the world of Aloe Vera to yohimbe, this site leaves no herbal medicines unexplored. As part of the Medline Plus omnibus site which was created by the U.S. National Library of Medicine and the National Institutes of Health, this particular section covers many aspects of the world of herbal medicine. First-time visitors will want to start by looking over the background essays on the use of botanical dietary supplements offered from the Office of Dietary Supplements. After that, they should browse through sections that include "Basics", "Learn More", "Research", and "Reference Shelf". They can also just scroll down through the homepage, which includes overviews on the use of different herbs and supplements. Those persons looking for the latest information about research findings on herbs and topical treatments can look within the "Latest News" listings, which are updated frequently. Researchers will appreciate the inclusion of a "Clinical Trials" area which provides the latest information about ongoing clinical trials that draw on various aspects of herbal medicine.

36

Medline Plus: Mammography  

NSDL National Science Digital Library

MedLine Plus has been bringing helpful medical and health information to the web-browsing public for over a decade, and they have always been committed to providing information for educators as well. As one of their more specialized sections, the mammography site contains information on how to perform mammograms, including several interactive tutorials. First-time visitors will want look at the âÂÂContents of this pageâ area, which allows them to move directly to sections such as âÂÂClinical TrialsâÂÂ, âÂÂResearchâÂÂ, âÂÂPictures/DiagramsâÂÂ, and âÂÂOverviewsâÂÂ. One nice touch is that the site draws on materials culled from a number of high-quality sources, including the National Cancer Institute, the National WomenâÂÂs Health Information Center, and the American Cancer Society. Two other resources here that are worth special mention are the Atlas of the Body (provided by the American Medical Association) and the multilingual mammogram tutorials offered in Chinese, Tagalog, and Vietnamese.

37

How to improve your PubMed/MEDLINE searches: 1. background and basic searching.  

PubMed

PubMed provides free access via the Internet to more than 23 million records, of which over 19 million are from the MEDLINE database of journal articles. PubMed also provides access to other databases, such as the NCBI Bookshelf. To perform a basic search, you can simply enter the search terms or the concept that you are looking for in the search box. However, taking care to clarify your key concepts may save much time later on, because a non-specific search is likely to produce an overwhelming number of result hits. One way to make your search more specific is to specify which field you want to search using field tags. By default, the results of a search are sorted by the date added to PubMed and displayed in summary format with 20 result hits (records) on each page. In summary format, the title of the article, list of authors, source of information (e.g., journal name followed by date of publication, volume, issue, pages) and the unique PubMed record number called the PubMed identifier (PMID) are shown. Although information is stored about the articles, PubMed/MEDLINE does not store the full text of the papers themselves. However, PubMedCentral (PMC) stores more than 2.8 million articles (roughly 10% of the articles in PubMed) and provides access to them for free to the users. PMID:24197398

Fatehi, Farhad; Gray, Leonard C; Wootton, Richard

2013-12-01

38

Mobile MedlinePlus | NIH MedlinePlus the Magazine  

MedlinePLUS

... Table of Contents Trusted medical information on your mobile phone http://m.medlineplus.gov Wondering what the side effects are for your new prescription? Go to Mobile MedlinePlus ( http://m.medlineplus.gov ) while you're ...

39

Mobile MedlinePlus | NIH MedlinePlus Magazine  

MedlinePLUS

... Table of Contents Trusted medical information on your mobile phone http://m.medlineplus.gov Wondering what the side effects are for your new prescription? Go to Mobile MedlinePlus while you're waiting for the pharmacist ...

40

PubMed searches: overview and strategies for clinicians.  

PubMed

PubMed is a biomedical and life sciences database maintained by a division of the National Library of Medicine known as the National Center for Biotechnology Information (NCBI). It is a large resource with more than 5600 journals indexed and greater than 22 million total citations. Searches conducted in PubMed provide references that are more specific for the intended topic compared with other popular search engines. Effective PubMed searches allow the clinician to remain current on the latest clinical trials, systematic reviews, and practice guidelines. PubMed continues to evolve by allowing users to create a customized experience through the My NCBI portal, new arrangements and options in search filters, and supporting scholarly projects through exportation of citations to reference managing software. Prepackaged search options available in the Clinical Queries feature also allow users to efficiently search for clinical literature. PubMed also provides information regarding the source journals themselves through the Journals in NCBI Databases link. This article provides an overview of the PubMed database's structure and features as well as strategies for conducting an effective search. PMID:23442731

Lindsey, Wesley T; Olin, Bernie R

2013-04-01

41

Evidence-based treatments for female pattern hair loss: a summary of a Cochrane systematic review.  

PubMed

Female pattern hair loss (FPHL) or androgenic alopecia is the most common type of hair loss affecting women with reduced hair density and can have a serious psychological impact. It is characterized by progressive replacement of slow cycling terminal hair follicles by miniaturized, rapidly cycling vellus hair follicles. The frontal hair line may or may not be preserved. The aim of this review was to assess the evidence for the effectiveness and safety of the treatments available for FPHL. Searches included: Cochrane Skin Group Specialised Register, Cochrane Central Register of Controlled Clinical Trials in The Cochrane Library, MEDLINE, EMBASE, AMED, PsycINFO, LILACS and several ongoing trials registries (October 2011). Randomized controlled trials in women with FPHL were identified. Twenty-two trials, comprising 2349 participants, were included. A range of interventions was evaluated, with 10 studies examining varying concentrations of minoxidil. Pooled data from four studies indicated that a greater proportion of participants treated with minoxidil reported a moderate increase in their hair regrowth compared with placebo (relative risk 1·86, 95% confidence interval 1·42-2·43). There was no difference between the number of adverse events experienced in the twice daily minoxidil and the placebo intervention groups, except for a reported increase with minoxidil 5% twice daily. Single studies accounted for most of the other comparisons, which were assessed as either having high risk of bias and/or they did not address the prespecified outcomes for this review and provided limited evidence of either the effectiveness or safety of these interventions. Further well-designed, adequately powered randomized controlled trials investigating other treatment options are still required. PMID:23039053

van Zuuren, E J; Fedorowicz, Z; Carter, B

2012-11-01

42

Retrieval of diagnostic and treatment studies for clinical use through PubMed and PubMed's Clinical Queries filters  

Microsoft Academic Search

ObjectiveClinical Queries filters were developed to improve the retrieval of high-quality studies in searches on clinical matters. The study objective was to determine the yield of relevant citations and physician satisfaction while searching for diagnostic and treatment studies using the Clinical Queries page of PubMed compared with searching PubMed without these filters.Materials and methodsForty practicing physicians, presented with standardized treatment

Cynthia Lokker; R Brian Haynes; Nancy L Wilczynski; K Ann McKibbon; Stephen D Walter

2011-01-01

43

Neuraminidase inhibitors: the story behind the Cochrane review  

E-print Network

Although billions have been spent on oseltamivir in the face of pandemic influenza, the team updating the Cochrane review of neuraminidase inhibitors in healthy adults found that the public evidence base for this global ...

Doshi, Peter

44

[The Hypertension Cochrane Review Group. Presentation and user's guide].  

PubMed

Cochrane collaboration has been developing since 1992 as an international network aiming at performing systematic reviews of available data on therapeutic effectiveness. The fundamental principles of this organisation are trying to avoid duplication of efforts, seeking the best reliability, using reproducible and quantitative synthesis techniques, offering constantly updated results. All health domains are progressively covered. The production unit in one domain is the review group. The Hypertension Cochrane Review Group (HTN CRG) has been officially registered on May 15th 1996. Information and products from the group are available through its news letter, through the Cochrane Library CD-ROM, regularly updated, and on the Internet (http://merece.uthscsa.edu/htncrg). The Hypertension Cochrane Review Group includes an editorial board (with an administrator and three editors), the authors of systematic reviews, internal and external reviewers. The geographic link is the San Antonio Cochrane Centre (Texas, USA). Invitations to participate have been sent to people interested in hypertension and who where known to the Cochrane collaboration, and to authors of previous reviews in hypertension. It is possible to collaborate with the HTN CRG through: performing a systematic review; reviewing protocols and systematic reviews; hand-searching medical journals; being a member of the editorial team. The first protocol for a systematic review edited by the group concerns antihypertensive treatment in the elderly, and is available in the 1996 and subsequent editions of the Cochrane Library. The group welcomes other reviews from domains awaiting registration, and collaborates with related domains review groups such as Diabetes CRG, or Stroke CRG. The group contributes to the effort of hand-searching medical literature, Pr Plouin being responsible for the Archives des Maladies du Coeur et des Vaisseaux. The second edition in 1996 of the Cochrane Library included 114 systematic reviews and 131 protocols, being the only media with similar objectives. PMID:9404428

Gueyffier, F; Boissel, J P; Haugh, M

1997-08-01

45

How Complementary and Alternative Medicine Practitioners Use PubMed  

PubMed Central

Background PubMed is the largest bibliographic index in the life sciences. It is freely available online and is used by professionals and the public to learn more about medical research. While primarily intended to serve researchers, PubMed provides an array of tools and services that can help a wider readership in the location, comprehension, evaluation, and utilization of medical research. Objective This study sought to establish the potential contributions made by a range of PubMed tools and services to the use of the database by complementary and alternative medicine practitioners. Methods In this study, 10 chiropractors, 7 registered massage therapists, and a homeopath (N = 18), 11 with prior research training and 7 without, were taken through a 2-hour introductory session with PubMed. The 10 PubMed tools and services considered in this study can be divided into three functions: (1) information retrieval (Boolean Search, Limits, Related Articles, Author Links, MeSH), (2) information access (Publisher Link, LinkOut, Bookshelf ), and (3) information management (History, Send To, Email Alert). Participants were introduced to between six and 10 of these tools and services. The participants were asked to provide feedback on the value of each tool or service in terms of their information needs, which was ranked as positive, positive with emphasis, negative, or indifferent. Results The participants in this study expressed an interest in the three types of PubMed tools and services (information retrieval, access, and management), with less well-regarded tools including MeSH Database and Bookshelf. In terms of their comprehension of the research, the tools and services led the participants to reflect on their understanding as well as their critical reading and use of the research. There was universal support among the participants for greater access to complete articles, beyond the approximately 15% that are currently open access. The abstracts provided by PubMed were felt to be necessary in selecting literature to read but entirely inadequate for both evaluating and learning from the research. Thus, the restrictions and fees the participants faced in accessing full-text articles were points of frustration. Conclusions The study found strong indications of PubMed’s potential value in the professional development of these complementary and alternative medicine practitioners in terms of engaging with and understanding research. It provides support for the various initiatives intended to increase access, including a recommendation that the National Library of Medicine tap into the published research that is being archived by authors in institutional archives and through other websites. PMID:17613489

Quint-Rapoport, Mia

2007-01-01

46

PubMed Central: An Archive of Life Science Journals  

NSDL National Science Digital Library

There has been an increased interest in open source publishing as of late, and the U.S government has gotten involved recently with the creation of PubMed Central (through the National Center for Biotechnology Information and the National Library of Medicine) in 2000. PubMed Central is a digital archive of life science journal literature which offers free and complete access to the contents of approximately 50 peer-reviewed journals, such as Applied and Environmental Microbiology, Dynamic Medicine, and the Journal of Bacteriology. The search engine is fairly straightforward, as users may elect to enter author names, journal titles in full, or by keywords. All told, PubMed currently contains many thousands of articles, many of which will be of great interest to researchers and students in these fields. Perhaps the most crucial features of PubMed are summarized in this passage from their overview section, which remarks thusly: "It also makes it possible to integrate the literature with a variety of other information resources such as sequence databases and other factual databases that are available to scientists, clinicians, and everyone else interested in the life sciences. The intentional and serendipitous discoveries that such links might foster excite us and stimulate us to move forward."

2005-11-05

47

PubMed advanced exercise: MeSH Searching  

E-print Network

achilles tendon and click Search. With MeSH searches, you enter only one search term at a time and you don can remove the need to enter multiple alternative terms to describe the same concept. For the following exercise, please search PubMed using: a) search terms that feature within the following

Rzepa, Henry S.

48

Spelling correction in the PubMed search engine  

Microsoft Academic Search

It is known that users of internet search engines often enter queries with misspellings in one or more search terms. Several web search engines make suggestions for correcting misspelled words, but the methods used are proprietary and unpublished to our knowledge. Here we describe the methodology we have developed to perform spelling correction for the PubMed search engine. Our approach

W. John Wilbur; Won Kim; Natalie Xie

2006-01-01

49

PubMed: a brief tutorial for physicians.  

PubMed

This article provides a brief overview of PubMed, an Internet search engine for peer reviewed medical literature. The examples illustrated here are designed for the life insurance medical director, but the examples can be easily modified for other literature searches commonly used by physicians, eg, diagnosis or treatment. PMID:16459953

Clark, Keith T

2005-01-01

50

Best Available Evidence in Cochrane Reviews on Herbal Medicine?  

PubMed Central

Cochrane reviews are considered by many to be the “gold standard” or the final word in medical conversation on a topic. We explored the eleven most relevant Cochrane reviews on herbal medicine and identified that frequently herbal medicines in the included studies had not been sufficiently well characterised. If data on the effects of the plant parts are unavailable, effects of co-active ingredients need to be considered and the plausibility of the study medications for the specific indications discussed. Effect sizes calculated from exploratory studies would be best used to determine the sample sizes required for future confirmatory studies, rather than as definitive reports of intervention effects. Reviews should be comprehensive, including discussion of putative adverse events and possible drug interactions. We suggest that the guidelines for preparing Cochrane reviews be revised and offer assistance in this task. PMID:23840246

Davidson, Elyad; Vlachojannis, Julia; Cameron, Melainie; Chrubasik, Sigrun

2013-01-01

51

Developing search strategies in medline on the occupational origin of diseases  

Microsoft Academic Search

Background In order to support occupational health practitioners, researchers, and experts (clinical librarians, guideline developers) who search the scientific literature in PubMed (Medline), we developed and evaluated an easy-to-use and effective search strategy. Methods We tested different combinations of search terms, in answering four case vignettes calculating sensitivity and precision in retrieving literature from a gold standard. The use of

Frederieke Schaafsma; Carel Hulshof; J. H. A. M. Verbeek; Jurriaan Bos; Heleen Dyserinck; Dijk van F. J. H

2006-01-01

52

Author Name Disambiguation in MEDLINE  

PubMed Central

Background We recently described “Author-ity,” a model for estimating the probability that two articles in MEDLINE, sharing the same author name, were written by the same individual. Features include shared title words, journal name, coauthors, medical subject headings, language, affiliations, and author name features (middle initial, suffix, and prevalence in MEDLINE). Here we test the hypothesis that the Author-ity model will suffice to disambiguate author names for the vast majority of articles in MEDLINE. Methods Enhancements include: (a) incorporating first names and their variants, email addresses, and correlations between specific last names and affiliation words; (b) new methods of generating large unbiased training sets; (c) new methods for estimating the prior probability; (d) a weighted least squares algorithm for correcting transitivity violations; and (e) a maximum likelihood based agglomerative algorithm for computing clusters of articles that represent inferred author-individuals. Results Pairwise comparisons were computed for all author names on all 15.3 million articles in MEDLINE (2006 baseline), that share last name and first initial, to create Author-ity 2006, a database that has each name on each article assigned to one of 6.7 million inferred author-individual clusters. Recall is estimated at ~98.8%. Lumping (putting two different individuals into the same cluster) affects ~0.5% of clusters, whereas splitting (assigning articles written by the same individual to >1 cluster) affects ~2% of articles. Impact The Author-ity model can be applied generally to other bibliographic databases. Author name disambiguation allows information retrieval and data integration to become person-centered, not just document-centered, setting the stage for new data mining and social network tools that will facilitate the analysis of scholarly publishing and collaboration behavior. Availability The Author-ity 2006 database is available for nonprofit academic research, and can be freely queried via http://arrowsmith.psych.uic.edu. PMID:20072710

TORVIK, VETLE I.; SMALHEISER, NEIL R.

2009-01-01

53

MedlinePlus.gov Turns 10!  

MedlinePLUS

... Home Current Issue Past Issues MedlinePlus.gov Turns 10! Past Issues / Fall 2008 Table of Contents For ... Michael Spencer, NIH NIH MedlinePlus Advisory Group celebrates 10 years of success. Photo courtesy of Michael Spencer, ...

54

Complex event extraction at PubMed scale  

PubMed Central

Motivation: There has recently been a notable shift in biomedical information extraction (IE) from relation models toward the more expressive event model, facilitated by the maturation of basic tools for biomedical text analysis and the availability of manually annotated resources. The event model allows detailed representation of complex natural language statements and can support a number of advanced text mining applications ranging from semantic search to pathway extraction. A recent collaborative evaluation demonstrated the potential of event extraction systems, yet there have so far been no studies of the generalization ability of the systems nor the feasibility of large-scale extraction. Results: This study considers event-based IE at PubMed scale. We introduce a system combining publicly available, state-of-the-art methods for domain parsing, named entity recognition and event extraction, and test the system on a representative 1% sample of all PubMed citations. We present the first evaluation of the generalization performance of event extraction systems to this scale and show that despite its computational complexity, event extraction from the entire PubMed is feasible. We further illustrate the value of the extraction approach through a number of analyses of the extracted information. Availability: The event detection system and extracted data are open source licensed and available at http://bionlp.utu.fi/. Contact: jari.bjorne@utu.fi PMID:20529932

Björne, Jari; Ginter, Filip; Pyysalo, Sampo; Tsujii, Jun'ichi; Salakoski, Tapio

2010-01-01

55

MedlinePlus Survey Results 2012  

MedlinePLUS

... results describe MedlinePlus and MedlinePlus en español users. Users provided this information in response to our online site surveys in 2012. Learn more about the American Customer Satisfaction Index survey used to gather MedlinePlus survey data. ...

56

Assessing and presenting summaries of evidence in Cochrane Reviews  

PubMed Central

Cochrane Reviews are intended to help providers, practitioners and patients make informed decisions about health care. The goal of the Cochrane Applicability and Recommendation Methods Group (ARMG) is to develop approaches, strategies and guidance that facilitate the uptake of information from Cochrane Reviews and their use by a wide audience with specific focus on developers of recommendations and on healthcare decision makers. This paper is part of a series highlighting developments in systematic review methodology in the 20 years since the establishment of The Cochrane Collaboration, and its aim is to present current work and highlight future developments in assessing and presenting summaries of evidence, with special focus on Summary of Findings (SoF) tables and Plain Language Summaries. A SoF table provides a concise and transparent summary of the key findings of a review in a tabular format. Several studies have shown that SoF tables improve accessibility and understanding of Cochrane Reviews. The ARMG and GRADE Working Group are working on further development of the SoF tables, for example by evaluating the degree of acceptable flexibility beyond standard presentation of SoF tables, developing SoF tables for diagnostic test accuracy reviews and interactive SoF tables (iSoF). The plain language summary (PLS) is the other main building block for dissemination of review results to end-users. The PLS aims to summarize the results of a review in such a way that health care consumers can readily understand them. Current efforts include the development of a standardized language to describe statistical results, based on effect size and quality of supporting evidence. Producing high quality PLS and SoF tables and making them compatible and linked would make it easier to produce dissemination products targeting different audiences (for example, providers, health policy makers, guideline developers). Current issues of debate include optimal presentation formats of SoF tables, the training required to produce SoF tables, and the extent to which the authors of Cochrane Reviews should provide explicit guidance to target audiences of patients, clinicians and policy-makers. PMID:24059250

2013-01-01

57

Assessing and presenting summaries of evidence in Cochrane Reviews.  

PubMed

Cochrane Reviews are intended to help providers, practitioners and patients make informed decisions about health care. The goal of the Cochrane Applicability and Recommendation Methods Group (ARMG) is to develop approaches, strategies and guidance that facilitate the uptake of information from Cochrane Reviews and their use by a wide audience with specific focus on developers of recommendations and on healthcare decision makers. This paper is part of a series highlighting developments in systematic review methodology in the 20 years since the establishment of The Cochrane Collaboration, and its aim is to present current work and highlight future developments in assessing and presenting summaries of evidence, with special focus on Summary of Findings (SoF) tables and Plain Language Summaries.A SoF table provides a concise and transparent summary of the key findings of a review in a tabular format. Several studies have shown that SoF tables improve accessibility and understanding of Cochrane Reviews.The ARMG and GRADE Working Group are working on further development of the SoF tables, for example by evaluating the degree of acceptable flexibility beyond standard presentation of SoF tables, developing SoF tables for diagnostic test accuracy reviews and interactive SoF tables (iSoF).The plain language summary (PLS) is the other main building block for dissemination of review results to end-users. The PLS aims to summarize the results of a review in such a way that health care consumers can readily understand them. Current efforts include the development of a standardized language to describe statistical results, based on effect size and quality of supporting evidence.Producing high quality PLS and SoF tables and making them compatible and linked would make it easier to produce dissemination products targeting different audiences (for example, providers, health policy makers, guideline developers).Current issues of debate include optimal presentation formats of SoF tables, the training required to produce SoF tables, and the extent to which the authors of Cochrane Reviews should provide explicit guidance to target audiences of patients, clinicians and policy-makers. PMID:24059250

Langendam, Miranda W; Akl, Elie A; Dahm, Philipp; Glasziou, Paul; Guyatt, Gordon; Schünemann, Holger J

2013-01-01

58

Mobile App versus Web App: a Comparison Using 2008–2012 “PubMed for Handhelds” Server Data  

PubMed Central

Recent surveys show that mobile apps are more popular than Web apps. Apple’s iTunes Store, now has about 800,000 apps and reported to have about 40 billion downloads. Android apps, although fewer, is available to the most number of smartphones today. About 40,000 apps are medical or health related. We developed a PubMed4Hh mobile app for iPhone/iPad users to search MEDLINE/PubMed with same features as our Web-based search tools, in use since 2002. Five-year (2008–2012) server data for PubMed4Hh and Web app were analyzed. Searches using the mobile app significantly increased compared to the same five-year time period. Month-by-month comparison showed a 3 to 5-fold increase in queries. The six-month total accesses comparison increased 280% from the previous four-year average. A review of 500 randomly selected queries revealed that the majority of queries were clinical questions ((97.8%) and 61% of these queries are searches related to therapy. PMID:24551349

Fontelo, Paul; Liu, Fang

2013-01-01

59

Mobile app versus Web app: a comparison using 2008-2012 "PubMed for Handhelds" server data.  

PubMed

Recent surveys show that mobile apps are more popular than Web apps. Apple's iTunes Store, now has about 800,000 apps and reported to have about 40 billion downloads. Android apps, although fewer, is available to the most number of smartphones today. About 40,000 apps are medical or health related. We developed a PubMed4Hh mobile app for iPhone/iPad users to search MEDLINE/PubMed with same features as our Web-based search tools, in use since 2002. Five-year (2008-2012) server data for PubMed4Hh and Web app were analyzed. Searches using the mobile app significantly increased compared to the same five-year time period. Month-by-month comparison showed a 3 to 5-fold increase in queries. The six-month total accesses comparison increased 280% from the previous four-year average. A review of 500 randomly selected queries revealed that the majority of queries were clinical questions ((97.8%) and 61% of these queries are searches related to therapy. PMID:24551349

Fontelo, Paul; Liu, Fang

2013-01-01

60

MedlinePlus FAQ: Can you tell me how to cite MedlinePlus pages?  

MedlinePLUS

... the article . Conuel T. Finding answers in a beauty shop. NIH MedlinePlus: the magazine [Internet]. 2012 Fall [ ... author identified Conuel T. Finding answers in a beauty shop. NIH MedlinePlus: the magazine. 2012 Fall; 7( ...

61

MedlinePlus FAQ: What's New on Medline Plus Page and Email Updates  

MedlinePLUS

... Cool Tools ESPAÑOL Question: How is the What's New on MedlinePlus page and RSS feed different from ... this page, please enable JavaScript. Answer: The What's New on MedlinePlus page and RSS feed include alerts ...

62

MELVYL MEDLINE: a library services perspective.  

PubMed Central

The MELVYL MEDLINE project resulted in the addition of a full five-year subset of MEDLINE to the University of California's (UC) MELVYL online union catalog. As one of the nation's largest MEDLINE end-user searching systems, MELVYL MEDLINE provides online bibliographic access to the biomedical journal literature for all UC personnel at over seventy library sites or by remote access. This paper summarizes the project's accomplishments, reports MELVYL MEDLINE use and its impact on library services, and provides insights for other end-user search systems. The project serves as a model for adding databases to the MELVYL catalog and demonstrates the potential for use by other disciplines of a specialized database when readily accessible. Evaluation results report high user satisfaction and high usage. However, many advanced searching features of the interface are little used by searchers. Effects on library services include marked increases in reference transactions and interlibrary loans, with significant declines in mediated search services. Future MELVYL MEDLINE enhancements include matching search retrievals to journal locations, linkage to an online document delivery system, and consideration of building a superset of databases by combining MELVYL MEDLINE with citations from another database in the MELVYL catalog. PMID:1884086

Horres, M M; Starr, S S; Renford, B L

1991-01-01

63

MELVYL MEDLINE: a library services perspective.  

PubMed

The MELVYL MEDLINE project resulted in the addition of a full five-year subset of MEDLINE to the University of California's (UC) MELVYL online union catalog. As one of the nation's largest MEDLINE end-user searching systems, MELVYL MEDLINE provides online bibliographic access to the biomedical journal literature for all UC personnel at over seventy library sites or by remote access. This paper summarizes the project's accomplishments, reports MELVYL MEDLINE use and its impact on library services, and provides insights for other end-user search systems. The project serves as a model for adding databases to the MELVYL catalog and demonstrates the potential for use by other disciplines of a specialized database when readily accessible. Evaluation results report high user satisfaction and high usage. However, many advanced searching features of the interface are little used by searchers. Effects on library services include marked increases in reference transactions and interlibrary loans, with significant declines in mediated search services. Future MELVYL MEDLINE enhancements include matching search retrievals to journal locations, linkage to an online document delivery system, and consideration of building a superset of databases by combining MELVYL MEDLINE with citations from another database in the MELVYL catalog. PMID:1884086

Horres, M M; Starr, S S; Renford, B L

1991-07-01

64

"Is Cybermedicine Killing You?" - The Story of a Cochrane Disaster  

PubMed Central

This editorial briefly reviews the series of unfortunate events that led to the publication, dissemination, and eventual retraction of a flawed Cochrane systematic review on interactive health communication applications (IHCAs), which was widely reported in the media with headlines such as "Internet Makes Us Sick," "Knowledge May Be Hazardous to Web Consumers' Health," "Too Much Advice Can Be Bad for Your Health," "Click to Get Sick?" and even "Is Cybermedicine Killing You?" While the media attention helped to speed up the identification of errors, leading to a retraction of the review after only 13 days, a paper published in this issue of JMIR by Rada shows that the retraction, in contrast to the original review, remained largely unnoticed by the public. We discuss the three flaws of the review, which include (1) data extraction and coding errors, (2) the pooling of heterogeneous studies, and (3) a problematic and ambiguous scope and, possibly, some overlooked studies. We then discuss "retraction ethics" for researchers, editors/publishers, and journalists. Researchers and editors should, in the case of retractions, match the aggressiveness of the original dissemination campaign if errors are detected. It is argued that researchers and their organizations may have an ethical obligation to track down journalists who reported stories on the basis of a flawed study and to specifically ask them to publish an article indicating the error. Journalists should respond to errors or retractions with reports that have the same prominence as the original story. Finally, we look at some of the lessons for the Cochrane Collaboration, which include (1) improving the peer-review system by routinely sending out pre-prints to authors of the original studies, (2) avoiding downplay of the magnitude of errors if they occur, (3) addressing the usability issues of RevMan, and (4) making critical articles such as retraction notices open access. PMID:15998612

Kummervold, Per Egil

2005-01-01

65

Selenium Supplementation for Hashimoto's Thyroiditis: Summary of a Cochrane Systematic Review  

PubMed Central

Selenium supplementation in people with Hashimoto's thyroiditis might reduce antibody levels and result in a decreased dosage of levothyroxine (LT4) and may provide other beneficial effects (e.g. on mood and health-related quality of life). The aim of our systematic review was to assess the effects of selenium supplementation on Hashimoto's thyroiditis. We searched The Cochrane Library, MEDLINE, EMBASE and Web of Science for randomized controlled trials. Study selection, data extraction, assessment of risk of bias and analyses were carried out by two independent review authors. We assessed the quality of the evidence of included studies using GRADE. Four studies rated at unclear to high risk of bias comprising 463 participants were included. One study at high risk of bias showed statistically significant improvement in subjective well-being with sodium selenite 200 ?g plus titrated LT4 compared with placebo plus titrated LT4 (RR 4.67, 95% CI 1.61-13.50). Selenomethionine 200 ?g as a single treatment or combined with LT4 reduced the serum levels of anti-thyroid peroxidase antibodies compared with placebo (or placebo plus LT4) in three studies (p < 0.001). Although the changes from baseline were statistically significant in these three studies, their clinical relevance is unclear. In conclusion, the results of these four studies, assessed at unclear to high risk of bias, show that evidence to support or refute the efficacy of selenium supplementation in people with Hashimoto's thyroiditis is incomplete and not reliable to help inform clinical decision making. PMID:24847462

van Zuuren, Esther J.; Albusta, Amira Y.; Fedorowicz, Zbys; Carter, Ben; Pijl, Hanno

2014-01-01

66

Development of biomedical publications on ametropia research in PubMed from 1845 to 2010: a bibliometric analysis  

PubMed Central

AIM We have carried out a bibliometric analysis on the development of ametropia literature to determine its growth rule and tendency, and to provide the basis for the problems related to ametropia research. METHODS Literatures that contained the descriptors of ametropia in title or paper published before Nov. 10, 2010 in PubMed databases (www.ncbi.nlm.nih.gov/Pubmed) were selected. As bibliometric indicators of ametropia, biomedical journals referring to ophthalmology by ISSN were calculated. The principal bibliometric indicators: Price's and Bradford's laws were applied on the increase or dispersion of scientific literature, the participation index of languages and the journals. By means of manual coding, literatures were classified according to documents study and statistical analysis. RESULTS The literatures cited in ametropia, astigmatism, myopia and hypermetropia had accumulated to 26475, which consists of Review (n=1560), Randomized Controlled Trial (n=776), Practice Guideline (n=10), Meta-Analysis (n=23), Letter (n=1222), Editorial (n=328), Clinical Trial (n=1726) and Others (n=20830), and Humans (n=23073), Animals(n=1434) and others (n=1968). 1136 literatures were included in PubMed Central, 22384 in MEDLINE and 2955 in others. The ametropia literatures rose every 5 years which of the ametropia-year cumulated amount of the literatures had three periods: before 1900, slowly increasing from 1901 to 1950, rapidly rising from 1951 to 2010 (increased approximate exponentiation exponent). Sixty kinds of languages listed in PubMed databases, of which English is dominant for aborting to ametropia research documents before 2010 (77.32%, 20471/26475). The document languages of top eight account for 95.58% (English, German, French, Japanese, Russian, Italian, Spanish, Chinese), and others for 4.42% (1171/26475). The SCI database includes 48 ophthalmologic journals and the impact factor of 39 journals is ?1 on Thomson-Reuters in 2010. Of 48 ophthalmologic journals, there were 14785 documents (55.85%) of ametropia, astigmatism, myopia, and hypermetropia. Others were without exception. CONCLUSION The bibliometric analysis results show that ametropia literature are increased progressively, approximate exponentiation exponent during 1951-2010. In addition, ametropia research has become more popular since nearly half century. PMID:22553598

Xu, Chang-Tai; Li, Shan-Qu; Lü, Yong-Gang; Pan, Bo-Rong

2011-01-01

67

Bibliometric analysis of leishmaniasis research in Medline (1945-2010)  

PubMed Central

Background Publications are often used as a measure of success of research work. Leishmaniasis is considered endemic in 98 countries, most of which are developing. This article describes a bibliometric review of the literature on leishmaniasis research indexed in PubMed during a 66-year period. Methods Medline was used via the PubMed online service of the US National Library of Medicine. The search strategy was Leishmania [MeSH] or leishmaniasis [MeSH] from 1 January 1945 until 31 December 2010. Neither language nor document type restrictions were employed. Results A total of 20,780 references were retrieved. The number of publications increased steadily over time, with 3,380 publications from 1945-1980 to 8,267 from 2001-2010. Leishmaniasis documents were published in 1,846 scientific journals, and Transactions of the Royal Society of Tropical Medicine and Hygiene (4.9%) was the top one. The USA was the predominant country by considering the first author’s institutional address (16.8%), followed by Brazil (14.9%), and then India (9.0%), however Brazil leads the scientific output in 2001-2010 period (18.5%), followed by the USA (13.5%) and India (10%). The production ranking changed when the number of publications was normalised by population (Israel and Switzerland), by gross domestic product (Nepal and Tunisia), and by gross national income per capita (India and Ethiopia). For geographical area, Europe led (31.7%), followed by Latin America (24.5%). Conclusions We have found an increase in the number of publications in the field of leishmaniasis. The USA and Brazil led scientific production on leishmaniasis research. PMID:23497410

2013-01-01

68

A short guide to peer-reviewed, MEDLINE-indexed complementary and alternative medicine journals.  

PubMed

Complementary and alternative medicine (CAM) comprises a multitude of disciplines, for example, acupuncture, ayurvedic medicine, biofeedback, herbal medicine, and homeopathic medicine. While research on CAM interventions has increased and the CAM literature has proliferated since the mid-1990s, a number of our colleagues have expressed difficulties in deciding where to publish CAM articles. In response, we created a short guide to peer-reviewed MEDLINE-indexed journals that publish CAM articles. We examined numerous English-language sources to identify titles that met our criteria, whether specific to or overlapping CAM. A few of the resources in which we found the journal titles that we included are Alternative Medicine Foundation, American Holistic Nurses Association, CINAHL/Nursing Database, Journal Citation Reports database, MEDLINE, PubMed, and Research Council for Complementary Medicine. We organized the 69 selected titles for easy use by creating 2 user-friendly tables, one listing titles in alphabetical order and one listing them in topical categories. A few examples of the topical categories are Acupuncture, CAM (general), Chinese Medicine, Herbal/Plant/Phytotherapy, Neuroscience/Psychology, Nursing/Clinical Care. Our study is the first to list general CAM journals, specialty CAM journals, and overlapping mainstream journals that are peer reviewed, in English, and indexed in MEDLINE. Our goal was to assist both authors seeking publication and mainstream journal editors who receive an overabundance of publishable articles but must recommend that authors seek publication elsewhere due to space and priority issues. Publishing in journals indexed by and included in MEDLINE (or PubMed) ensures that citations to articles will be found easily. PMID:22517352

Morgan, Sherry; Littman, Lynn; Palmer, Christina; Singh, Gurneet; LaRiccia, Patrick J

2012-01-01

69

MedlinePlus Connect: Email List  

MedlinePLUS

... Topics Drugs & Supplements Videos & Cool Tools MedlinePlus Connect: Email List To use the sharing features on this ... developments and exchange ideas with your colleagues. This email list will be useful for health IT developers ...

70

Poor Reliability between Cochrane Reviewers and Blinded External Reviewers When Applying the Cochrane Risk of Bias Tool in Physical Therapy Trials  

PubMed Central

Objectives To test the inter-rater reliability of the RoB tool applied to Physical Therapy (PT) trials by comparing ratings from Cochrane review authors with those of blinded external reviewers. Methods Randomized controlled trials (RCTs) in PT were identified by searching the Cochrane Database of Systematic Reviews for meta-analysis of PT interventions. RoB assessments were conducted independently by 2 reviewers blinded to the RoB ratings reported in the Cochrane reviews. Data on RoB assessments from Cochrane reviews and other characteristics of reviews and trials were extracted. Consensus assessments between the two reviewers were then compared with the RoB ratings from the Cochrane reviews. Agreement between Cochrane and blinded external reviewers was assessed using weighted kappa (?). Results In total, 109 trials included in 17 Cochrane reviews were assessed. Inter-rater reliability on the overall RoB assessment between Cochrane review authors and blinded external reviewers was poor (? ?=? 0.02, 95%CI: ?0.06, 0.06]). Inter-rater reliability on individual domains of the RoB tool was poor (median ? ?=?0.19), ranging from ? ?=? ?0.04 (“Other bias”) to ? ?=? 0.62 (“Sequence generation”). There was also no agreement (? ?=? ?0.29, 95%CI: ?0.81, 0.35]) in the overall RoB assessment at the meta-analysis level. Conclusions Risk of bias assessments of RCTs using the RoB tool are not consistent across different research groups. Poor agreement was not only demonstrated at the trial level but also at the meta-analysis level. Results have implications for decision making since different recommendations can be reached depending on the group analyzing the evidence. Improved guidelines to consistently apply the RoB tool and revisions to the tool for different health areas are needed. PMID:24824199

Armijo-Olivo, Susan; Ospina, Maria; da Costa, Bruno R.; Egger, Matthias; Saltaji, Humam; Fuentes, Jorge; Ha, Christine; Cummings, Greta G.

2014-01-01

71

Analysis of the reporting of search strategies in Cochrane systematic reviews*  

PubMed Central

Background: The Cochrane Handbook for Systematic Reviews of Interventions provides instructions for documenting a systematic review's electronic database search strategy, listing elements that should be in the description. Complete documentation of the search strategy allows readers to evaluate the search when critically appraising a review's quality. Objective: The research analyzed recently published Cochrane reviews to determine whether instructions for describing electronic database search strategies were being followed. Methods: Eighty-three new reviews added to the Cochrane Database of Systematic Reviews in the first quarter of 2006 were selected for analysis. Eighteen were subsequently excluded because their searches were conducted only in the specialized registers of Cochrane review groups. The remaining sixty-five reviews were analyzed for the seven elements of an electronic database search strategy description listed in the Cochrane Handbook, using dual review with consensus. Results: Of the 65 reviews analyzed, none included all 7 recommended elements. Four reviews (6%) included 6 elements. Thirty-two percent (21/65) included 5 or more elements, with 68% (44/65) including 4 or fewer. Three included only 2 elements. The 65 reviews represented 41 different Cochrane review groups. Conclusion: The instructions from the Cochrane Handbook for reporting search strategies are not being consistently employed by groups producing Cochrane reviews. PMID:19158999

Yoshii, Adriana; McGraw, Kathleen A.; Anderson, Margaret J.; Wellik, Kay E.

2009-01-01

72

ADAM: another database of abbreviations in MEDLINE  

Microsoft Academic Search

Motivation: Abbreviations are an important type of terminology in the biomedical domain. Although several groups have already created databases of biomedical abbreviations, these are either not public, or are not comprehensive, or focus exclusively on acronym-type abbre- viations. We have created another abbreviation database, ADAM, which covers commonly used abbreviations and their definitions (or long-forms) within MEDLINE titles and abstracts,

Wei Zhou; Vetle I. Torvik; Neil R. Smalheiser

2006-01-01

73

Open Biomedical Ontology-based Medline exploration  

PubMed Central

Background Effective Medline database exploration is critical for the understanding of high throughput experimental results and the development of novel hypotheses about the mechanisms underlying the targeted biological processes. While existing solutions enhance Medline exploration through different approaches such as document clustering, network presentations of underlying conceptual relationships and the mapping of search results to MeSH and Gene Ontology trees, we believe the use of multiple ontologies from the Open Biomedical Ontology can greatly help researchers to explore literature from different perspectives as well as to quickly locate the most relevant Medline records for further investigation. Results We developed an ontology-based interactive Medline exploration solution called PubOnto to enable the interactive exploration and filtering of search results through the use of multiple ontologies from the OBO foundry. The PubOnto program is a rich internet application based on the FLEX platform. It contains a number of interactive tools, visualization capabilities, an open service architecture, and a customizable user interface. It is freely accessible at: . PMID:19426463

Xuan, Weijian; Dai, Manhong; Mirel, Barbara; Song, Jean; Athey, Brian; Watson, Stanley J; Meng, Fan

2009-01-01

74

PubMed enhancements: fulfilling the promise of a great product.  

PubMed

There have been many recent changes to PubMed to enhance its usefulness. Those changes include: LinkOut Libraries (local holding field), PubMed Central (full-text articles archived by the National Library of Medicine), and LinkOut (access to full-text articles right from the PubMed citation). Medical librarians should be aware of how these features work to best assist their clients. These new features offer the possibility of true desktop access for library patrons. Not only will patrons appreciate these new features, but their use in libraries will literally change what we do, who does it, and how it is done. PMID:15778178

Schott, Michael J

2004-01-01

75

PubMed QUICK GUIDE University of California Berkeley Library Use this URL to access the UCcustomized version of PubMed, with links to UCBsubscribed full text  

E-print Network

PubMed searching is easy: just enter terms in the search box and click Search. The Advanced Search link below the search box provides access to additional searching options. Keyword Searching Enter combines (ANDs) significant terms together using automatic term mapping, matching your search terms

76

Effect of cannabis usage on the oral environment: a review  

Microsoft Academic Search

Aim: To evaluate oral environmental changes in cannabis users. Material and Methods: The MEDLINE and Cochrane Central register of controlled trails (CENTRAL) were searched up to April 2007 to identify appropriate studies. Results: Independent screening of 982 titles and abstracts (MEDLINE-Pubmed) and (Cochrane) papers resulted in seven eligible publications. Conclusion: Based on the limited data, it seems justified to conclude

P. A. Versteeg; D. E. Slot; Velden van der U; Weijden van der G. A

2008-01-01

77

Extracting noun phrases for all of MEDLINE.  

PubMed Central

A natural language parser that could extract noun phrases for all medical texts would be of great utility in analyzing content for information retrieval. We discuss the extraction of noun phrases from MEDLINE, using a general parser not tuned specifically for any medical domain. The noun phrase extractor is made up of three modules: tokenization; part-of-speech tagging; noun phrase identification. Using our program, we extracted noun phrases from the entire MEDLINE collection, encompassing 9.3 million abstracts. Over 270 million noun phrases were generated, of which 45 million were unique. The quality of these phrases was evaluated by examining all phrases from a sample collection of abstracts. The precision and recall of the phrases from our general parser compared favorably with those from three other parsers we had previously evaluated. We are continuing to improve our parser and evaluate our claim that a generic parser can effectively extract all the different phrases across the entire medical literature. PMID:10566444

Bennett, N. A.; He, Q.; Powell, K.; Schatz, B. R.

1999-01-01

78

Impact of Including Korean Randomized Controlled Trials in Cochrane Reviews of Acupuncture  

PubMed Central

Objective Acupuncture is commonly practiced in Korea and is regularly evaluated in clinical trials. Although many Cochrane reviews of acupuncture include searches of both English and Chinese databases, there is no information on the value of searching Korean databases. This study aimed to investigate the impact of searching Korean databasesand journals for trials eligible for inclusion in existing Cochrane acupuncture reviews. Methods We searched 12 Korean databases and seven Korean journals to identify randomised trials meeting the inclusion criteria for acupuncture reviews in the Cochrane Database of Systematic Reviews. We compared risk of bias assessments of the Korean trials with the trials included in the Cochrane acupuncture reviews. Where possible, we added data from the Korean trials to the existing meta-analyses in the relevant Cochrane review and conducted sensitivity analyses to test the robustness of the results. Results Sixteen Korean trials (742 participants) met the inclusion criteria for eight Cochrane acupuncture reviews (125 trials; 13,041 participants). Inclusion of the Korean trials provided data for 20% of existing meta-analyses (24 out of 120). Inclusion of the Korean trials did not change the direction of effect in any of the existing meta-analyses. The effect size and heterogeneity remained mostly unchanged. In only one meta-analysis did the significance change. Compared to the studies included in the Cochrane acupuncture reviews, the risk of bias in the Korean trials was higher in terms of outcome assessor blinding and allocation concealment. Conclusions Many Korean studies contributed additional data to the existing meta-analyses in Cochrane acupuncture reviews. Although inclusion of these studies did not alter the results of the meta-analyses, comprehensive searches of the literature are important to avoid potential language bias. The identification and inclusion of eligible Korean trials should be considered for reviews of acupuncture. PMID:23071826

Kim, Kun Hyung; Kong, Jae Cheol; Choi, Jun-Yong; Choi, Tae-Young; Shin, Byung-Cheul; McDonald, Steve; Lee, Myeong Soo

2012-01-01

79

MedlinePlus FAQ: Easy-to-Read Documents  

MedlinePLUS

... are easy to read and what is their reading level? To use the sharing features on this ... all materials on MedlinePlus are at the same reading level. MedlinePlus does not decide the literacy level ...

80

MEDLINE: the options for health professionals.  

PubMed Central

The bibliographic database MEDLINE, produced by the National Library of Medicine (NLM), is a computerized index to the world's biomedical literature. The database can be searched back to 1966 and contains 6.8 million records. The various means of access are divided, for the purposes of this article, into three categories: logging onto a remote host computer by telephone and modem or by the Internet; subscribing to part or all of the database on compact disc (CD-ROM); and leasing the data on a transport medium such as magnetic tape or CDs for loading on a local host computer. Decisions about which method is preferable in a given situation depend on cost, availability of hardware and software, local expertise, and the size of the intended user population. Trends include increased access to the Internet by health professionals, increased network speed, links from MEDLINE records to full-text databases or online journals, and integration of MEDLINE into wider health information systems. PMID:7850561

Wood, E H

1994-01-01

81

Reporting of conflicts of interest from drug trials in Cochrane reviews: cross sectional study  

PubMed Central

Objectives To investigate the degree to which Cochrane reviews of drug interventions published in 2010 reported conflicts of interest from included trials and, among reviews that reported this information, where it was located in the review documents. Design Cross sectional study. Data sources Cochrane Database of Systematic Reviews. Selection criteria Systematic reviews of drug interventions published in 2010 in the Cochrane Database of Systematic Reviews, with review content classified as up to date in 2008 or later and with results from one or more randomised controlled trials. Results Of 151 included Cochrane reviews, 46 (30%, 95% confidence interval 24% to 38%) reported information on the funding sources of included trials, including 30 (20%, 14% to 27%) that reported information on trial funding for all included trials and 16 (11%, 7% to 17%) that reported for some, but not all, trials. Only 16 of the 151 Cochrane reviews (11%, 7% to 17%) provided any information on trial author-industry financial ties or trial author-industry employment. Information on trial funding and trial author-industry ties was reported in one to seven locations within each review, with no consistent reporting location observed. Conclusions Most Cochrane reviews of drug trials published in 2010 did not provide information on trial funding sources or trial author-industry financial ties or employment. When this information was reported, location of reporting was inconsistent across reviews. PMID:22906823

2012-01-01

82

Measuring Medical Student Preference: A Comparison of Classroom Versus Online Instruction for Teaching Pubmed*EC  

PubMed Central

Objective: The research analyzed evaluation data to assess medical student satisfaction with the learning experience when required PubMed training is offered entirely online. Methods: A retrospective study analyzed skills assessment scores and student feedback forms from 455 first-year medical students who completed PubMed training either through classroom sessions or an online tutorial. The class of 2006 (n?=?99) attended traditional librarian-led sessions in a computer classroom. The classes of 2007 (n?=?120), 2008 (n?=?121), and 2009 (n?=?115) completed the training entirely online through a self-paced tutorial. PubMed skills assessment scores and student feedback about the training were compared for all groups. Results: As evidenced by open-ended comments about the training, students who took the online tutorial were equally or more satisfied with the learning experience than students who attended classroom sessions, with the classes of 2008 and 2009 reporting greater satisfaction (P<0.001) than the other 2 groups. The mean score on the PubMed skills assessment (91%) was the same for all groups of students. Conclusions: Student satisfaction improved and PubMed assessment scores did not change when instruction was offered online to first-year medical students. Comments from the students who received online training suggest that the increased control and individual engagement with the web-based content led to their satisfaction with the online tutorial. PMID:18654658

Schimming, Laura M.

2008-01-01

83

An automatic method to generate domain-specific investigator networks using PubMed abstracts  

PubMed Central

Background Collaboration among investigators has become critical to scientific research. This includes ad hoc collaboration established through personal contacts as well as formal consortia established by funding agencies. Continued growth in online resources for scientific research and communication has promoted the development of highly networked research communities. Extending these networks globally requires identifying additional investigators in a given domain, profiling their research interests, and collecting current contact information. We present a novel strategy for building investigator networks dynamically and producing detailed investigator profiles using data available in PubMed abstracts. Results We developed a novel strategy to obtain detailed investigator information by automatically parsing the affiliation string in PubMed records. We illustrated the results by using a published literature database in human genome epidemiology (HuGE Pub Lit) as a test case. Our parsing strategy extracted country information from 92.1% of the affiliation strings in a random sample of PubMed records and in 97.0% of HuGE records, with accuracies of 94.0% and 91.0%, respectively. Institution information was parsed from 91.3% of the general PubMed records (accuracy 86.8%) and from 94.2% of HuGE PubMed records (accuracy 87.0). We demonstrated the application of our approach to dynamic creation of investigator networks by creating a prototype information system containing a large database of PubMed abstracts relevant to human genome epidemiology (HuGE Pub Lit), indexed using PubMed medical subject headings converted to Unified Medical Language System concepts. Our method was able to identify 70–90% of the investigators/collaborators in three different human genetics fields; it also successfully identified 9 of 10 genetics investigators within the PREBIC network, an existing preterm birth research network. Conclusion We successfully created a web-based prototype capable of creating domain-specific investigator networks based on an application that accurately generates detailed investigator profiles from PubMed abstracts combined with robust standard vocabularies. This approach could be used for other biomedical fields to efficiently establish domain-specific investigator networks. PMID:17584920

Yu, Wei; Yesupriya, Ajay; Wulf, Anja; Qu, Junfeng; Gwinn, Marta; Khoury, Muin J

2007-01-01

84

Strategies to improve retention in randomised trials: a Cochrane systematic review and meta-analysis  

PubMed Central

Objective To quantify the effect of strategies to improve retention in randomised trials. Design Systematic review and meta-analysis. Data sources Sources searched: MEDLINE, EMBASE, PsycINFO, DARE, CENTRAL, CINAHL, C2-SPECTR, ERIC, PreMEDLINE, Cochrane Methodology Register, Current Controlled Trials metaRegister, WHO trials platform, Society for Clinical Trials (SCT) conference proceedings and a survey of all UK clinical trial research units. Review methods Included trials were randomised evaluations of strategies to improve retention embedded within host randomised trials. The primary outcome was retention of trial participants. Data from trials were pooled using the fixed-effect model. Subgroup analyses were used to explore the heterogeneity and to determine whether there were any differences in effect by the type of strategy. Results 38 retention trials were identified. Six broad types of strategies were evaluated. Strategies that increased postal questionnaire responses were: adding, that is, giving a monetary incentive (RR 1.18; 95% CI 1.09 to 1.28) and higher valued incentives (RR 1.12; 95% CI 1.04 to 1.22). Offering a monetary incentive, that is, an incentive given on receipt of a completed questionnaire, also increased electronic questionnaire response (RR 1.25; 95% CI 1.14 to 1.38). The evidence for shorter questionnaires (RR 1.04; 95% CI 1.00 to 1.08) and questionnaires relevant to the disease/condition (RR 1.07; 95% CI 1.01 to 1.14) is less clear. On the basis of the results of single trials, the following strategies appeared effective at increasing questionnaire response: recorded delivery of questionnaires (RR 2.08; 95% CI 1.11 to 3.87); a ‘package’ of postal communication strategies (RR 1.43; 95% CI 1.22 to 1.67) and an open trial design (RR 1.37; 95% CI 1.16 to 1.63). There is no good evidence that the following strategies impact on trial response/retention: adding a non-monetary incentive (RR=1.00; 95% CI 0.98 to 1.02); offering a non-monetary incentive (RR=0.99; 95% CI 0.95 to 1.03); ‘enhanced’ letters (RR=1.01; 95% CI 0.97 to 1.05); monetary incentives compared with offering prize draw entry (RR=1.04; 95% CI 0.91 to 1.19); priority postal delivery (RR=1.02; 95% CI 0.95 to 1.09); behavioural motivational strategies (RR=1.08; 95% CI 0.93 to 1.24); additional reminders to participants (RR=1.03; 95% CI 0.99 to 1.06) and questionnaire question order (RR=1.00, 0.97 to 1.02). Also based on single trials, these strategies do not appear effective: a telephone survey compared with a monetary incentive plus questionnaire (RR=1.08; 95% CI 0.94 to 1.24); offering a charity donation (RR=1.02, 95% CI 0.78 to 1.32); sending sites reminders (RR=0.96; 95% CI 0.83 to 1.11); sending questionnaires early (RR=1.10; 95% CI 0.96 to 1.26); longer and clearer questionnaires (RR=1.01, 0.95 to 1.07) and participant case management by trial assistants (RR=1.00; 95% CI 0.97 to 1.04). Conclusions Most of the trials evaluated questionnaire response rather than ways to improve participants return to site for follow-up. Monetary incentives and offers of monetary incentives increase postal and electronic questionnaire response. Some strategies need further evaluation. Application of these results would depend on trial context and follow-up procedures. PMID:24496696

Brueton, V C; Tierney, J F; Stenning, S; Meredith, S; Harding, S; Nazareth, I; Rait, G

2014-01-01

85

Systematic reviews published in the july 2014 issue of the cochrane library.  

PubMed

ABSTRACT The Cochrane Library of Systematic Reviews is published quarterly as a DVD and monthly online ( http://www.thecochranelibrary.com ). The July 2014 issue (3rd DVD for 2014) contains 6050 complete reviews, 2,359 protocols for reviews in production, and 31,000 short summaries of systematic reviews published in the general medical literature. In addition, there are citations of 789,000 randomized controlled trials, and 15,700 cited papers in the Cochrane Methodology Register. The Health Technology Assessment database contains some 14,000 citations. Ninety-six new reviews have been published in the previous 3 months of which five have potential relevance for practitioners in pain and palliative medicine. The impact factor of the Cochrane Library stands at 5.715. Readers are encouraged to access the full report for any articles of interest as only a brief commentary is provided. PMID:25338103

Wiffen, Philip J

2014-12-01

86

The impact of Cochrane Systematic Reviews: a mixed method evaluation of outputs from Cochrane Review Groups supported by the UK National Institute for Health Research  

PubMed Central

Background There has been a growing emphasis on evidence-informed decision-making in health care. Systematic reviews, such as those produced by the Cochrane Collaboration, have been a key component of this movement. The UK National Institute for Health Research (NIHR) Systematic Review Programme currently supports 20 Cochrane Review Groups (CRGs). The aim of this study was to identify the impacts of Cochrane reviews published by NIHR-funded CRGs during the years 2007–2011. Methods We sent questionnaires to CRGs and review authors, interviewed guideline developers and used bibliometrics and documentary review to get an overview of CRG impact and to evaluate the impact of a sample of 60 Cochrane reviews. We used a framework with four categories (knowledge production, research targeting, informing policy development and impact on practice/services). Results A total of 1,502 new and updated reviews were produced by the 20 NIHR-funded CRGs between 2007 and 2011. The clearest impacts were on policy with a total of 483 systematic reviews cited in 247 sets of guidance: 62 were international, 175 national (87 from the UK) and 10 local. Review authors and CRGs provided some examples of impact on practice or services, for example, safer use of medication, the identification of new effective drugs or treatments and potential economic benefits through the reduction in the use of unproven or unnecessary procedures. However, such impacts are difficult to objectively document, and the majority of reviewers were unsure if their review had produced specific impacts. Qualitative data suggested that Cochrane reviews often play an instrumental role in informing guidance, although a poor fit with guideline scope or methods, reviews being out of date and a lack of communication between CRGs and guideline developers were barriers to their use. Conclusions Health and economic impacts of research are generally difficult to measure. We found that to be the case with this evaluation. Impacts on knowledge production and clinical guidance were easier to identify and substantiate than those on clinical practice. Questions remain about how we define and measure impact, and more work is needed to develop suitable methods for impact analysis. PMID:25348511

2014-01-01

87

How can a proposed Cochrane diet and nutrition field work effectively?  

PubMed

The Cochrane Database currently provides relatively little evidence-based guidance about nutrition relevant to general practitioners. This situation could be improved by the establishment of a new Cochrane Field to identify relevant studies, prioritize topics to include nutrition, work with Cochrane methodologists on the inclusion of observational studies, and disseminate results of Cochrane reviews to general practitioners and their patients. A Diet and Nutrition Field could be established as a separate entity or as a Subgroup of the existing Primary Health Care (PHC) Field. The Field would be appropriate if the intent is to immediately cover nutritional interventions of all sorts, in all settings. However, if the focus is nutritional evidence for use by primary care clinicians, organization as a subField would provide a simpler registration process, allow Cochrane activities to begin sooner, and would allow members to focus on primary-care-relevant nutritional issues, conserving their resources and energy. A mechanism exists for conversion to a freestanding Field if the scope later expands. Of the core Field functions, identification and assembly of relevant trials into a specialized register would be among the most important. Special registers are generated by focused literature searches augmented by hand-searching of key journals. Given the importance of studies with observational designs, a nutrition field register will require some additional work on search strategies and inclusion criteria. Other key functions would include ensuring effective communication both with members of other Cochrane entities and with the scientific and clinical community with interests in diet and nutrition. PMID:16052186

Becker, L A; van Binsbergen, J J

2005-08-01

88

Comparison of PubMed, Scopus, Web of Science, and Google Scholar: strengths and weaknesses  

Microsoft Academic Search

The evolution of the electronic age has led to the development of numerous medical databases on the World Wide Web, offering search facilities on a particular subject and the ability to perform citation analysis. We compared the content coverage and prac- tical utility of PubMed, Scopus, Web of Science, and Google Scholar. The official Web pages of the data- bases

Matthew E. Falagas; Eleni I. Pitsouni; George A. Malietzis; Georgios Pappas

2007-01-01

89

Risk Factors for Bladder Cancer: Challenges of Conducting a Literature Search Using PubMed  

PubMed Central

The objective of this study was to assess the risk factors for bladder cancer using PubMed articles from January 2000 to December 2009. The study also aimed to describe the challenges encountered in the methodology of a literature search for bladder cancer risk factors using PubMed. Twenty-six categories of risk factors for bladder cancer were identified using the National Cancer Institute Web site and the Medical Subject Headings (MeSH) Web site. A total of 1,338 PubMed searches were run using the term “urinary bladder cancer” and a risk factor term (e.g., “cigarette smoking”) and were screened to identify 260 articles for final analysis. The search strategy had an overall precision of 3.42 percent, relative recall of 12.64 percent, and an F -measure of 5.39 percent. Although search terms derived from MeSH had the highest overall precision and recall, the differences did not reach significance, which indicates that for generalized, free-text searches of the PubMed database, the searchers' own terms are generally as effective as MeSH terms. PMID:21464862

Joshi, Ashish; Preslan, Elicia

2011-01-01

90

A SNPshot of PubMed to associate genetic variants with drugs, diseases, and adverse reactions  

E-print Network

A SNPshot of PubMed to associate genetic variants with drugs, diseases, and adverse reactions Jörg, drug efficacy, and drug responses between individuals and sub-populations. Wrong dosages of drugs can lead to severe adverse drug reac- tions in individuals whose drug metabolism drastically differs from

Baral, Chitta

91

Mining Novellas from PubMed Abstracts using a Storytelling Algorithm  

E-print Network

Mining Novellas from PubMed Abstracts using a Storytelling Algorithm Joseph Gresock , Deept Kumar the systematic application of a `storytelling' algorithm followed by compression of the stories into `novellas.' Given a start and end publication, typically with little or no overlap in content, storytelling

Ramakrishnan, Naren

92

Geography of Africa biomedical publications: An analysis of 1996–2005 PubMed papers  

Microsoft Academic Search

BACKGROUND: Scientific publications play an important role in scientific process providing a key linkage between knowledge production and use. Scientific publishing activity worldwide over the past decades shows that most countries in Africa have low levels of publication. We sought to examine trends and contribution of different Africa subregions and individual countries as represented by the articles indexed by PubMed

Olalekan A Uthman; Mubashir B Uthman

2007-01-01

93

RERANKING MEDLINE CITATIONS BY RELEVANCE TO A DIFFICULT BIOLOGICAL QUERY  

E-print Network

to express as PubMed query. Our proposed approach to this problem is to train support vector machines improvements were achieved in reranking citations with respect to protein disorder-function relationships where PubMed with disordered protein names. By our reranking method, this was improved to about 58% and 78

Obradovic, Zoran

94

The Cochran-Mantel-Haenszel test and the Lucia de Berk case  

E-print Network

is binary: success or fail. In an investigation of a sus- pected serial killer nurse, the experimental unitsThe Cochran-Mantel-Haenszel test and the Lucia de Berk case Richard D. Gill July 4, 2007 Abstract The asymptotic power of the Mantel-Haenszel test is compared to that of its competitors. 1 Introduction Suppose

Gill, Richard D.

95

Autism Teaching Suite Jefrey Cochran, Kirill Marants, Simon Sidhom, Jamison Mortimer, Jamison  

E-print Network

Andaluz Senior Design Expo Department of Computer Science Introduction The Autism Teaching Suite (ATSs Autism Teaching Suite Jefrey Cochran, Kirill Marants, Simon Sidhom, Jamison Mortimer, Jamison, multimodal learning environment. s Wheel Organizer ·Used for adding, removing, and reorganizing wheel content

Kamberov, George

96

Assessing Diagnostic Expertise of Counselors Using the Cochran-Weiss-Shanteau (CWS) Index  

ERIC Educational Resources Information Center

Counseling studies have shown that increasing experience is not always associated with better judgments. However, in such studies performance is assessed against external criteria, which may lack validity. The authors applied the Cochran-Weiss-Shanteau (CWS) index, which assesses the ability to consistently discriminate. Results showed that novice…

Witteman, Cilia L. M.; Weiss, David J.; Metzmacher, Martin

2012-01-01

97

Issues in the incorporation of economic perspectives and evidence into Cochrane reviews  

PubMed Central

Background Methods for systematic reviews of the effects of health interventions have focused mainly on addressing the question of 'What works?’ or 'Is this intervention effective in achieving one or more specific outcomes?’ Addressing the question 'Is it worth it given the resources available?’ has received less attention. This latter question can be addressed by applying an economic lens to the systematic review process. This paper reflects on the value and desire for the consideration by end users for coverage of an economic perspective in a Cochrane review and outlines two potential approaches and future directions. Methods Two frameworks to guide review authors who are seeking to include an economic perspective are outlined. The first involves conducting a full systematic review of economic evaluations that is integrated into a review of intervention effects. The second involves developing a brief economic commentary. The two approaches share a set of common stages but allow the tailoring of the economic component of the Cochrane review to the skills and resources available to the review team. Results The number of studies using the methods outlined in the paper is limited, and further examples are needed both to explore the value of these approaches and to further develop them. The rate of progress will hinge on the organisational leadership, capacity and resources available to the CCEMG, author teams and other Cochrane entities. Particular methodological challenges to overcome relate to understanding the key economic trade-offs and casual relationships for a given decision problem and informing the development of evaluations designed to support local decision-makers. Conclusions Methods for incorporating economic perspectives and evidence into Cochrane intervention reviews are established. Their role is not to provide a precise estimate of 'cost-effectiveness’ but rather to help end-users of Cochrane reviews to determine the implications of the economic components of reviews for their own specific decisions. PMID:24050504

2013-01-01

98

PubMedAlertMe--standalone Windows-based PubMed SDI software application.  

PubMed

PubMedAlertMe is a Windows-based software system for automatically receiving e-mail alert messages about recent publications listed on PubMed. The e-mail messages contain links to newly available abstracts listed on PubMed describing publications that were selectively returned from a specified list of queries. Links are also provided to directly export citations to EndNote, and links are provided to directly forward articles to colleagues. The program is standalone. Thus, it does not require a remote mail server or user registration. PubMedAlertMe is free software, and can be downloaded from: http://amp.pharm.mssm.edu/PubMedAlertMe/PubMedAlertMe_setup.zip. PMID:18402930

Ma'ayan, Avi

2008-05-01

99

PubCrawler: keeping up comfortably with PubMed and GenBank  

Microsoft Academic Search

The free PubCrawler web service (http:\\/\\/www. pubcrawler.ie) has been operating for five years and sofarhasbroughtliteratureandsequenceupdatesto over 22000 users. It provides information on a perso- nalized web page whenever new articles appear in PubMed or when new sequences are found in GenBank that are specific to customized queries. The server also acts as an automatic alerting system by sending out short

Karsten Hokamp; Kenneth H. Wolfe

2004-01-01

100

Increasing dominance of English in publications archived by PubMed  

Microsoft Academic Search

English is becoming the international language in numerous fields of human civilization. We sought to evaluate the extent\\u000a of use of English in the field of biomedical publications. We searched in PubMed for the number of articles written in the\\u000a 57 indexed languages, during each one of the four past 10-year periods. The extent of use of English as the

Politimi Eleni Valkimadi; Drosos E. Karageorgopoulos; Harissios Vliagoftis; Matthew E. Falagas

2009-01-01

101

Posted 3/2/13 Medline Industries Industrial Engineer  

E-print Network

Posted 3/2/13 Medline Industries ­ Industrial Engineer Medline Industries, Inc. has an immediate opening for an Industrial Engineer for our SPT Division located in Waukegan, IL. We are seeking a hard-working, detail-oriented professional with experience in industrial engineering and lean manufacturing within

Heller, Barbara

102

77 FR 65545 - Mr. Jesse S. Capel and Mr. Hilton J. Cochran; EWP LLC; Notice of Transfer of Exemption  

Federal Register 2010, 2011, 2012, 2013

...Commission [Project No. 4815-009] Mr. Jesse S. Capel and Mr. Hilton J. Cochran; EWP LLC; Notice of Transfer of Exemption 1...supplemented on August 14, 2012, Mr. Jesse S. Capel and Mr. Hilton J. Cochran and EWP LLC informed the Commission that its...

2012-10-29

103

Evidence-based clinical behavior analysis, evidence-based medicine and the Cochrane collaboration  

Microsoft Academic Search

Encouraging professionals in training and later to consider practice-related research findings when making important clinical decisions is an on-going concern. Evidenced-Based Medicine (EBM) and the Cochrane Collaboration (CC) provide a source of tools and ideas for doing so, as well as a roster of colleagues who share this interest. Evidenced-based medicine involves integrating clinical expertise with the best available external

Eileen Gambrill

1999-01-01

104

Assessing bias in osteoarthritis trials included in Cochrane reviews: protocol for a meta-epidemiological study  

PubMed Central

Introduction The validity of systematic reviews and meta-analysis depends on methodological quality and unbiased dissemination of trials. Our objective is to evaluate the association of estimates of treatment effects with different bias-related study characteristics in meta-analyses of interventions used for treating pain in osteoarthritis (OA). From the findings, we hope to consolidate guidance on interpreting OA trials in systematic reviews based on empirical evidence from Cochrane reviews. Methods and analysis Only systematic reviews that compare experimental interventions with sham, placebo or no intervention control will be considered eligible. Bias will be assessed with the risk of bias tool, used according to the Cochrane Collaboration’s recommendations. Furthermore, center status, trial size and funding will be assessed. The primary outcome (pain) will be abstracted from the first appearing forest plot for overall pain in the Cochrane review. Treatment effect sizes will be expressed as standardised mean differences (SMDs), where the difference in mean values available from the forest plots is divided by the pooled SD. To empirically assess the risk of bias in treatment benefits, we will perform stratified analyses of the trials from the included meta-analyses and assess the interaction between trial characteristics and treatment effect. A relevant study-level covariate is defined as one that decreases the between-study variance (?2, estimated as Tau-squared) as a consequence of inclusion in the mixed effects statistical model. Ethics and dissemination Meta-analyses and randomised controlled trials provide the most reliable basis for treatment of patients with OA, but the actual impact of bias is unclear. This study will systematically examine the methodological quality in OA Cochrane reviews and explore the effect estimates behind possible bias. Since our study does not collect primary data, no formal ethical assessment and informed consent are required. Trial registration number PROSPERO (CRD42013006924). PMID:25280805

Hansen, Julie B; Juhl, Carsten B; Boutron, Isabelle; Tugwell, Peter; Ghogomu, Elizabeth A T; Pardo Pardo, Jordi; Rader, Tamara; Wells, George A; Mayhew, Alain; Maxwell, Lara; Lund, Hans; Christensen, Robin

2014-01-01

105

[Patient participation in the Cochrane Collaboration--barriers, experience, and concepts in Germany].  

PubMed

The aim of the Cochrane Collaboration (CC) is to bridge the gap of information transfer between the clinician and the patient. For this purpose, the CC pursues since years the concept of involving the consumers in the process of collaborative review groups. In spite of a positive experience altogether, some barriers (for example the communication between the scientists involved in CC review groups and the patients) remain to be overcome. To improve the information transfer, the Cochrane Hematological Malignancies Group (CHMG) has built a consumer network within the initiatives of the German Cancer Association, for example devising specific training concepts. The German Cochrane Center, on the other hand, focuses on direct information of patients and interested consumers, and provides translated consumer synopses of all available systematic reviews (SR) adapted for use in the German health system. In the future, it will be necessary to develop more concepts to optimize the patient participation process, and to find methods to measure the impact of these projects on the patient outcome. PMID:16121652

Weingart, Olaf; Skoetz, Nicole; Lang, Britta; Richter, Bernd; Engert, Andreas

2005-01-01

106

Beyond PubMed: Searching the "Grey Literature" for Clinical Trial Results  

PubMed Central

Clinical trial results have been traditionally communicated through the publication of scholarly reports and reviews in biomedical journals. However, this dissemination of information can be delayed or incomplete, making it difficult to appraise new treatments, or in the case of missing data, evaluate older interventions. Going beyond the routine search of PubMed, it is possible to discover additional information in the “grey literature.” Examples of the grey literature include clinical trial registries, patent databases, company and industrywide repositories, regulatory agency digital archives, abstracts of paper and poster presentations on meeting/congress websites, industry investor reports and press releases, and institutional and personal websites. PMID:25337445

2014-01-01

107

Qatar biomedical and cancer publications in PubMed between 2000 and 2012  

PubMed Central

Background: The aim of this work was to analyse the past trends of biomedical and cancer publications from Qatar listed on PubMed for the years 2000–2012. These findings were then compared with the corresponding global number of publications. Methods: PubMed was searched for cancer publications, clinical trials, publications on humans or other species. Searching for “Qatar*” in the “Affiliation” field yielded the lowest number of publications; searching for “Qatar*” in the “Affiliation” or in “Title/Abstract” yielded a moderate number of results and searching for “Qatar*” in the “Affiliation” or “Title/Abstract” or “Text Word” fields yielded the highest number of publications. The annual percentage change (APC) from one year to the next was calculated for the population and each type of publication. Information on the population of Qatar was gathered from the website of Qatar Statistics Authority to determine the correlation of papers published per 1000 population. Results: The number of publications retrieved from PubMed was not particularly different for each variation of search carried out. However, the most representative number of publications was retrieved upon searching for “Qatar*” in the “Affiliation” or in “Title/Abstract” fields. Between the years 2000 and 2012, the total number of biomedical publications from Qatar increased 24 times with an average APC of 33.4%, which was found to be more than the APC of the population in Qatar which averaged at 9%. The number of biomedical publications per 1000 population increased from 0.02 in 2000 to 0.15% in 2012. Most publications retrieved were humans studies and occasionally were for other animal species. Cancer publications in Qatar represented 16.9% of the total publications and the number of cancer publications per 1000 population increased from 0% in 2000 to 0.02% in 2012. Publications classified as clinical trials represented 4.6% of Qatar biomedical publications. Publication of cancer clinical trials were very rare (0.4%). Conclusions: Despite the obvious increase in Qatar biomedical and cancer publications in PubMed, the absolute numbers were relatively small. While strategies are in place, leaders of Qatar biomedical research need to consider increasing cancer research and clinical trials to meet the country's needs. Linking research output to researchers, research facilities and research funding is needed.

Zeeneldin, Ahmed A.; Taha, Fatma Mohamed

2014-01-01

108

Beyond PubMed: Searching the "Grey Literature" for Clinical Trial Results.  

PubMed

Clinical trial results have been traditionally communicated through the publication of scholarly reports and reviews in biomedical journals. However, this dissemination of information can be delayed or incomplete, making it difficult to appraise new treatments, or in the case of missing data, evaluate older interventions. Going beyond the routine search of PubMed, it is possible to discover additional information in the "grey literature." Examples of the grey literature include clinical trial registries, patent databases, company and industrywide repositories, regulatory agency digital archives, abstracts of paper and poster presentations on meeting/congress websites, industry investor reports and press releases, and institutional and personal websites. PMID:25337445

Citrome, Leslie

2014-07-01

109

Down the Block... Around the World...MedlinePlus.gov  

MedlinePLUS

... Issue Past Issues Down the Block... Around the World...MedlinePlus.gov Past Issues / Spring 2008 Table of ... on. No matter where you are in the world, www.medlineplus.gov is your best global source ...

110

Treating Cataracts | NIH MedlinePlus the Magazine  

MedlinePLUS

... her experience recently with NIH MedlinePlus magazine. What did you notice about your vision that told you ... how long it would take to recover. Where did you go for information about cataracts and surgery? ...

111

Mary Tyler Moore Helps Launch NIH MedlinePlus Magazine  

MedlinePLUS

... Home Current Issue Past Issues Mary Tyler Moore Helps Launch NIH MedlinePlus Magazine Past Issues / Winter 2007 ... and tireless diabetes research advocate Mary Tyler Moore help launch the first official issue of the magazine ...

112

History and Trends of "Personal Health Record" Research in PubMed  

PubMed Central

Objectives The purpose of this study was to review history and trends of personal health record research in PubMed and to provide accurate understanding and categorical analysis of expert opinions. Methods For the search strategy, PubMed was queried for 'personal health record, personal record, and PHR' in the title and abstract fields. Those containing different definitions of the word were removed by one-by-one analysis from the results, 695 articles. In the end, total of 229 articles were analyzed in this research. Results The results show that the changes in terms over the years and the shift to patient centeredness and mixed usage. And we identified history and trend of PHR research in some category that the number of publications by year, topic, methodologies and target diseases. Also from analysis of MeSH terms, we can show the focal interest in regards the PHR boundaries and related subjects. Conclusions For PHRs to be efficiently used by general public, initial understanding of the history and trends of PHR research may be helpful. Simultaneously, accurate understanding and categorical analysis of expert opinions that can lead to the development and growth of PHRs will be valuable to their adoption and expansion. PMID:21818452

Kim, Jeongeun; Bates, David W.

2011-01-01

113

Cochran eorms0330.tex V1 -July 14, 2010 2:17 P.M. P. 1 FORECASTING FOR INVENTORY  

E-print Network

/Wharton Merchandising Effectiveness Project [1] have found that these subjective forecasts tend to have an average Research and Management Science, edited by James J. Cochran Copyright © 2010 John Wiley & Sons, Inc. Times

114

Open, small-incision, or laparoscopic cholecystectomy for patients with symptomatic cholecystolithiasis : an overview of Cochrane HepatoBiliary Group reviews  

Microsoft Academic Search

BACKGROUND: Patients with symptomatic cholecystolithiasis are treated by three different techniques of cholecystectomy: open, small-incision, or laparoscopic. There is no overview on Cochrane systematic reviews on these three interventions. OBJECTIVES: To summarise Cochrane reviews that assess the effects of different techniques of cholecystectomy for patients with symptomatic cholecystolithiasis. METHODS: The Cochrane Database of Systematic Reviews (CDSR) was searched for all

F. Keus; H. G. Gooszen

2010-01-01

115

[Analysis of the Cochrane Review: Vitamin D supplementation for prevention of cancer in adults. Cochrane Database Syst Rev. 2014, 6:CD007469].  

PubMed

Vitamin D has been mentioned in the literature has a potentially important agent for preventing the development of tumors, namely breast, colon, prostate and ovary tumors. However, the currently available evidence on the subject is contradictory and inconclusive. In this Cochrane systematic review, patients taking supplemental vitamin D on its various forms (cholecalciferol, ergocalciferol, alfacalcidol or calcitriol), regardless the dose, duration and route of administration, were compared with placebo, healthy adults without any intervention or adults with a disease in a stable phase, non-related with vitamin D metabolism. The results showed that currently, there is no firm evidence that vitamin D supplementation increases or decreases the risk of cancer occurrence, mainly in elderly community-dwelling women. Though at risk of type I errors due to small samples and substantial dropout of participants during the trials, the administration of supplemental cholecalciferol led to a 12% (CI 95%: 2 a 22%) decreased in cancer mortality, while the administration of supplemental vitamin D decreased all-cause mortality by 7% (CI 95%: 2 a 12%). The combined administration of supplements of cholecalciferol and calcium induced an increased incidence of nephrolithiasis. PMID:25203945

Cardoso, André Torres; Nanji, Liliana; Costa, João; Vaz-Carneiro, António

2014-01-01

116

The value of using verbs in Medline searches.  

PubMed

New findings are continuously identified thanks to novel diagnostic procedures, among others in medical imaging. It would be useful to retrieve these new findings from literature. The aim of this work is to investigate if using verbs in MEDLINE queries can improve the retrieval of findings. Verbs used in the field of findings were selected: 'to show' (an examination shows a finding) and 'to confirm' (a finding confirms a diagnosis). For each of these verbs, semantically close verbs were researched on the WordNet website. Then, the extent to which adding these verbs to a query about various radiological pathologies can improve findings retrieval in Medline citations was studied. This method has been tested on two sets of MEDLINE citations regarding the diagnostic imaging of musculo-skeletal disorders. Using appropriate verbs in Medline queries enhances the precision from 53% to 61% and from 53% to 74%, respectively, in our first and second test set. A recall of 74% and 83% was reached in our two experiments. Using relevant verbs can be a rather simple way to improve the retrieval of findings related to diseases and diagnostic procedures from Medline citations. PMID:17541861

Bertaud, Valerie; Said, W; Garcelon, Nicolas; Marin, Franck; Duvauferrier, Regis

2007-06-01

117

Tumor necrosis factor-alpha antagonists twenty years later: what do cochrane reviews tell us?  

PubMed

: In 1998, the U.S. Food and Drug Administration granted regulatory approval to the first tumor necrosis factor-? antagonist, infliximab, for the treatment of moderately to severely active Crohn's disease. As of 2013, there were 3 additional tumor necrosis factor-? antagonists commercially available for the treatment of inflammatory bowel disease in the United States: adalimumab, certolizumab pegol, and golimumab. Despite a vast literature describing both clinical trial and clinical practice experience with these agents, there remain important questions regarding the efficacy and safety of tumor necrosis factor-? antagonists for the treatment of inflammatory bowel disease. These questions and the best available evidence to answer them were discussed during a Cochrane Collaboration session held at the 2013 Digestive Diseases Week annual meeting. This article reviews the data from that session. PMID:25299543

Akobeng, Anthony A; Sandborn, William J; Bickston, Stephen J; Chande, Nilesh; Shackelton, Lisa M; Nelson, Sigrid; Feagan, Brian G

2014-11-01

118

Cochrane re-arranged: support for policies to vaccinate elderly people against influenza.  

PubMed

The 2010 Cochrane review on efficacy, effectiveness and safety of influenza vaccination in the elderly by Jefferson et al. covering dozens of clinical studies over a period of four decades, confirmed vaccine safety, but found no convincing evidence for vaccine effectiveness (VE) against disease thus challenging the ongoing efforts to vaccinate the elderly. However, the Cochrane review analyzed and presented the data in a way that may itself have hampered the desired separation of real vaccine benefits from inevitable 'background noise'. The data are arranged in more than one hundred stand-alone meta-analyses, according to various vaccine types, study designs, populations, and outcome case definitions, and then further subdivided according to virus circulation and antigenic match. In this way, general vaccine effects could not be separated from an abundance of environmental and operational, non vaccine-related variation. Furthermore, expected impacts of changing virus circulation and antigenic drift on VE could not be demonstrated. We re-arranged the very same data according to a biological and conceptual framework based on the basic sequence of events throughout the 'patient journey' (exposure, infection, clinical outcome, observation) and using broad outcome definitions and simple frequency distributions of VE values. This approach produced meaningful predictions for VE against influenza-related fatal and non-fatal complications (average ~30% with large dispersion), typical influenza-like illness (~40%), disease with confirmed virus infection (~50%), and biological vaccine efficacy against infection (~60%), under conditions of virus circulation. We could also demonstrate a VE average around zero in the absence of virus circulation, and decreasing VE values with decreasing virus circulation and increasing antigenic drift. We regard these findings as substantial evidence for the ability of influenza vaccine to reduce the risk of influenza infection and influenza-related disease and death in the elderly. PMID:24095882

Beyer, Walter E P; McElhaney, Janet; Smith, Derek J; Monto, Arnold S; Nguyen-Van-Tam, Jonathan S; Osterhaus, Albert D M E

2013-12-01

119

Use of weaning protocols for reducing duration of mechanical ventilation in critically ill adult patients: Cochrane systematic review and meta-analysis  

PubMed Central

Objective To investigate the effects of weaning protocols on the total duration of mechanical ventilation, mortality, adverse events, quality of life, weaning duration, and length of stay in the intensive care unit and hospital. Design Systematic review. Data sources Cochrane Central Register of Controlled Trials, Medline, Embase, CINAHL, LILACS, ISI Web of Science, ISI Conference Proceedings, Cambridge Scientific Abstracts, and reference lists of articles. We did not apply language restrictions. Review methods We included randomised and quasi-randomised controlled trials of weaning from mechanical ventilation with and without protocols in critically ill adults. Data selection Three authors independently assessed trial quality and extracted data. A priori subgroup and sensitivity analyses were performed. We contacted study authors for additional information. Results Eleven trials that included 1971 patients met the inclusion criteria. Compared with usual care, the geometric mean duration of mechanical ventilation in the weaning protocol group was reduced by 25% (95% confidence interval 9% to 39%, P=0.006; 10 trials); the duration of weaning was reduced by 78% (31% to 93%, P=0.009; six trials); and stay in the intensive care unit length by 10% (2% to 19%, P=0.02; eight trials). There was significant heterogeneity among studies for total duration of mechanical ventilation (I2=76%, P<0.01) and duration of weaning (I2=97%, P<0.01), which could not be explained by subgroup analyses based on type of unit or type of approach. Conclusion There is evidence of a reduction in the duration of mechanical ventilation, weaning, and stay in the intensive care unit when standardised weaning protocols are used, but there is significant heterogeneity among studies and an insufficient number of studies to investigate the source of this heterogeneity. Some studies suggest that organisational context could influence outcomes, but this could not be evaluated as it was outside the scope of this review. PMID:21233157

2011-01-01

120

Extracting Biochemical Interactions from MEDLINE Using a Link Grammar Parser  

E-print Network

. Introduction MEDLINE is a rich source for mining biochemical in- teractions for various tasks) approaches. More attention has been paid to the latter, probably due to the fact that the single sentence (NLP's main focus) is a good choice of text unit for min- ing biochemical interactions [3], and many

Berleant, Daniel

121

Death, dying and informatics: misrepresenting religion on MedLine  

Microsoft Academic Search

BACKGROUND: The globalization of medical science carries for doctors worldwide a correlative duty to deepen their understanding of patients' cultural contexts and religious backgrounds, in order to satisfy each as a unique individual. To become better informed, practitioners may turn to MedLine, but it is unclear whether the information found there is an accurate representation of culture and religion. To

Pablo Rodríguez del Pozo; Joseph J Fins

2005-01-01

122

Rethinking Drinking | NIH MedlinePlus the Magazine  

MedlinePLUS

... severe the disorder, many people can benefit from treatment. Talk with your doctor to determine the best course of action for you. Find Out More MedlinePlus www.medlineplus.gov National Institute on Alcohol Abuse and Alcoholism (NIAAA) www.niaaa.nih.gov Alcoholics Anonymous (AA) ...

123

Semi-automatic semantic annotation of PubMed Queries: a study on quality, efficiency, satisfaction  

PubMed Central

Information processing algorithms require significant amounts of annotated data for training and testing. The availability of such data is often hindered by the complexity and high cost of production. In this paper, we investigate the benefits of a state-of-the-art tool to help with the semantic annotation of a large set of biomedical information queries. Seven annotators were recruited to annotate a set of 10,000 PubMed® queries with 16 biomedical and bibliographic categories. About half of the queries were annotated from scratch, while the other half were automatically pre-annotated and manually corrected. The impact of the automatic pre-annotations was assessed on several aspects of the task: time, number of actions, annotator satisfaction, inter-annotator agreement, quality and number of the resulting annotations. The analysis of annotation results showed that the number of required hand annotations is 28.9% less when using pre-annotated results from automatic tools. As a result, the overall annotation time was substantially lower when pre-annotations were used, while inter-annotator agreement was significantly higher. In addition, there was no statistically significant difference in the semantic distribution or number of annotations produced when pre-annotations were used. The annotated query corpus is freely available to the research community. This study shows that automatic pre-annotations are found helpful by most annotators. Our experience suggests using an automatic tool to assist large-scale manual annotation projects. This helps speed-up the annotation time and improve annotation consistency while maintaining high quality of the final annotations. PMID:21094696

Neveol, Aurelie; Islamaj-Dogan, Rezarta; Lu, Zhiyong

2010-01-01

124

Mining locus tags in PubMed Central to improve microbial gene annotation  

PubMed Central

Background The scientific literature contains millions of microbial gene identifiers within the full text and tables, but these annotations rarely get incorporated into public sequence databases. We propose to utilize the Open Access (OA) subset of PubMed Central (PMC) as a gene annotation database and have developed an R package called pmcXML to automatically mine and extract locus tags from full text, tables and supplements. Results We mined locus tags from 1835 OA publications in ten microbial genomes and extracted tags mentioned in 30,891 sentences in main text and 20,489 rows in tables. We identified locus tag pairs marking the start and end of a region such as an operon or genomic island and expanded these ranges to add another 13,043 tags. We also searched for locus tags in supplementary tables and publications outside the OA subset in Burkholderia pseudomallei K96243 for comparison. There were 168 publications containing 48,470 locus tags and 83% of mentions were from supplementary materials and 9% from publications outside the OA subset. Conclusions B. pseudomallei locus tags within the full text and tables of OA publications represent only a small fraction of the total mentions in the literature. For microbial genomes with very few functionally characterized proteins, the locus tags mentioned in supplementary tables and within ranges like genomic islands contain the majority of locus tags. Significantly, the functions in the R package provide access to additional resources in the OA subset that are not currently indexed or returned by searching PMC. PMID:24499370

2014-01-01

125

Linking Tacit Knowledge in the Pediatric Pain e-Mail Archives and Explicit Knowledge in PubMed  

E-print Network

Linking Tacit Knowledge in the Pediatric Pain e-Mail Archives and Explicit Knowledge in Pub and linked directly to the explicit knowledge found in PubMed. The Pediatric Pain Mailing List (PPML of pediatric pain has been recognized widely in the past fifteen years. Although knowledge about pediatric pain

Abidi, Syed Sibte Raza

126

Shifting Sands: Science Researchers on Google Scholar, Web of Science, and PubMed, with Implications for Library Collections Budgets  

ERIC Educational Resources Information Center

Science researchers at the University of California Santa Cruz were surveyed about their article database use and preferences in order to inform collection budget choices. Web of Science was the single most used database, selected by 41.6%. Statistically there was no difference between PubMed (21.5%) and Google Scholar (18.7%) as the second most…

Hightower, Christy; Caldwell, Christy

2010-01-01

127

Concordance of Adherence Measurement Using Self-Reported Adherence Questionnaires and Medication Monitoring Devices  

Microsoft Academic Search

The primary objective of this review was to identify and examine the literature on the association between medication adherence self-reported questionnaires (SRQs) and medication monitoring devices. The primary literature search was performed for 1980-2009 using PubMed, PubMed In Process and Non-Indexed, Ovid MEDLINE, Ovid MEDLINE In-Process, PsycINFO (EBSCO), CINAHL (EBSCO), Ovid HealthStar, EMBASE (Elsevier) and Cochrane Databases and using the

Lizheng Shi; Jinan Liu; Yordanka Koleva; Vivian Fonseca; Anupama Kalsekar; Manjiri Pawaskar

2010-01-01

128

Functional Cohesion of Gene Sets Determined by Latent Semantic Indexing of PubMed Abstracts  

PubMed Central

High-throughput genomic technologies enable researchers to identify genes that are co-regulated with respect to specific experimental conditions. Numerous statistical approaches have been developed to identify differentially expressed genes. Because each approach can produce distinct gene sets, it is difficult for biologists to determine which statistical approach yields biologically relevant gene sets and is appropriate for their study. To address this issue, we implemented Latent Semantic Indexing (LSI) to determine the functional coherence of gene sets. An LSI model was built using over 1 million Medline abstracts for over 20,000 mouse and human genes annotated in Entrez Gene. The gene-to-gene LSI-derived similarities were used to calculate a literature cohesion p-value (LPv) for a given gene set using a Fisher's exact test. We tested this method against genes in more than 6,000 functional pathways annotated in Gene Ontology (GO) and found that approximately 75% of gene sets in GO biological process category and 90% of the gene sets in GO molecular function and cellular component categories were functionally cohesive (LPv<0.05). These results indicate that the LPv methodology is both robust and accurate. Application of this method to previously published microarray datasets demonstrated that LPv can be helpful in selecting the appropriate feature extraction methods. To enable real-time calculation of LPv for mouse or human gene sets, we developed a web tool called Gene-set Cohesion Analysis Tool (GCAT). GCAT can complement other gene set enrichment approaches by determining the overall functional cohesion of data sets, taking into account both explicit and implicit gene interactions reported in the biomedical literature. Availability GCAT is freely available at http://binf1.memphis.edu/gcat PMID:21533142

Xu, Lijing; Furlotte, Nicholas; Lin, Yunyue; Heinrich, Kevin; Berry, Michael W.; George, Ebenezer O.; Homayouni, Ramin

2011-01-01

129

Outcomes in Cochrane Systematic Reviews Addressing Four Common Eye Conditions: An Evaluation of Completeness and Comparability  

PubMed Central

Introduction Choice of outcomes is critical for clinical trialists and systematic reviewers. It is currently unclear how systematic reviewers choose and pre-specify outcomes for systematic reviews. Our objective was to assess the completeness of pre-specification and comparability of outcomes in all Cochrane reviews addressing four common eye conditions. Methods We examined protocols for all Cochrane reviews as of June 2013 that addressed glaucoma, cataract, age-related macular degeneration (AMD), and diabetic retinopathy (DR). We assessed completeness and comparability for each outcome that was named in ?25% of protocols on those topics. We defined a completely-specified outcome as including information about five elements: domain, specific measurement, specific metric, method of aggregation, and time-points. For each domain, we assessed comparability in how individual elements were specified across protocols. Results We identified 57 protocols addressing glaucoma (22), cataract (16), AMD (15), and DR (4). We assessed completeness and comparability for five outcome domains: quality-of-life, visual acuity, intraocular pressure, disease progression, and contrast sensitivity. Overall, these five outcome domains appeared 145 times (instances). Only 15/145 instances (10.3%) were completely specified (all five elements) (median?=?three elements per outcome). Primary outcomes were more completely specified than non-primary (median?=?four versus two elements). Quality-of-life was least completely specified (median?=?one element). Due to largely incomplete outcome pre-specification, conclusive assessment of comparability in outcome usage across the various protocols per condition was not possible. Discussion Outcome pre-specification was largely incomplete; we encourage systematic reviewers to consider all five elements. This will indicate the importance of complete specification to clinical trialists, on whose work systematic reviewers depend, and will indirectly encourage comparable outcome choice to reviewers undertaking related research questions. Complete pre-specification could improve efficiency and reduce bias in data abstraction and analysis during a systematic review. Ultimately, more completely specified and comparable outcomes could make systematic reviews more useful to decision-makers. PMID:25329377

Saldanha, Ian J.; Dickersin, Kay; Wang, Xue; Li, Tianjing

2014-01-01

130

Multi-species Interactions: Indirect Effects D. Liane Cochran-Stafira, J. Timothy Wootton, and Christine A. Andrews  

E-print Network

for developing and testing theoretical concepts in community ecology. She teaches courses in ecology, evolution, Chicago, IL 60655 cochran@sxu.edu Department of Ecology and Evolution, University of Chicago 1101 East 57 interactions on the structure and dynamics of ecological communities. Her current research focuses

Cochran-Stafira, D. Liane

131

Mentoring programs for medical students - a review of the PubMed literature 2000 - 2008  

PubMed Central

Background Although mentoring is acknowledged as a key to successful and satisfying careers in medicine, formal mentoring programs for medical students are lacking in most countries. Within the framework of planning a mentoring program for medical students at Zurich University, an investigation was carried out into what types of programs exist, what the objectives pursued by such programs are, and what effects are reported. Methods A PubMed literature search was conducted for 2000 - 2008 using the following keywords or their combinations: mentoring, mentoring program, medical student, mentor, mentee, protégé, mentorship. Although a total of 438 publications were identified, only 25 papers met the selection criteria for structured programs and student mentoring surveys. Results The mentoring programs reported in 14 papers aim to provide career counseling, develop professionalism, increase students' interest in research, and support them in their personal growth. There are both one-to-one and group mentorships, established in the first two years of medical school and continuing through graduation. The personal student-faculty relationship is important in that it helps students to feel that they are benefiting from individual advice and encourages them to give more thought to their career choices. Other benefits are an increase in research productivity and improved medical school performance in general. Mentored students also rate their overall well-being as higher. - The 11 surveys address the requirements for being an effective mentor as well as a successful mentee. A mentor should empower and encourage the mentee, be a role model, build a professional network, and assist in the mentee's personal development. A mentee should set agendas, follow through, accept criticism, and be able to assess performance and the benefits derived from the mentoring relationship. Conclusion Mentoring is obviously an important career advancement tool for medical students. In Europe, more mentoring programs should be developed, but would need to be rigorously assessed based on evidence of their value in terms of both their impact on the career paths of juniors and their benefit for the mentors. Medical schools could then be monitored with respect to the provision of mentorships as a quality characteristic. PMID:20433727

2010-01-01

132

Cochrane corner: is integrated disease management for patients with COPD effective?  

PubMed

Patients with COPD experience respiratory symptoms, impairments of daily living and recurrent exacerbations. The aim of integrated disease management (IDM) is to establish a programme of different components of care (ie, self-management, exercise, nutrition) in which several healthcare providers (ie, nurses, general practitioners, physiotherapists, pulmonologists) collaborate to provide efficient and good quality of care. The aim of this Cochrane systematic review was to evaluate the effectiveness of IDM on quality of life, exercise tolerance and exacerbation related outcomes. Searches for all available evidence were carried out in various databases. Included randomised controlled trials (RCTs) consisted of interventions with multidisciplinary (?2 healthcare providers) and multitreatment (?2 components) IDM interventions with duration of at least 3?months. Two reviewers independently searched, assessed and extracted data of all RCTs. A total of 26 RCTs were included, involving 2997 patients from 11 different countries with a follow-up varying from 3 to 24?months. In all 68% of the patients were men, with a mean age of 68?years and a mean forced expiratory volume in 1?s (FEV1) predicted value of 44.3%. Patients treated with an IDM programme improved significantly on quality of life scores and reported a clinically relevant improvement of 44?m on 6?min walking distance, compared to controls. Furthermore, the number of patients with ?1 respiratory related hospital admission reduced from 27 to 20 per 100 patients. Duration of hospitalisation decreased significantly by nearly 4?days. PMID:24415716

Kruis, Annemarije L; Smidt, Nynke; Assendelft, Willem J J; Gussekloo, Jacobijn; Boland, Melinde R S; Rutten-van Mölken, Maureen; Chavannes, Niels H

2014-11-01

133

MEDLINE end-user survey: the University of Florida experience.  

PubMed

The University of Florida Health Science Center Library (UF-HSCL) surveyed MEDLINE end-user activities of the faculty from the six colleges which the UF-HSCL serves. A questionnaire was developed and sent to all faculty members. The Basic SAS program was used to analyze the collected data. This survey was intended to identify the users, the reasons for faculty members not being end users, the purpose for searching MEDLINE, the information retrieval methods, the level of end-user satisfaction, and the librarian's role in information retrieval activities. Many findings from this survey were in agreement with those of the 1988 study by the National Library of Medicine. PMID:10111720

Hsu, P P

1991-01-01

134

BRS Colleague MEDLINE end user training follow-up survey.  

PubMed

The amount of recent literature describing end user training programs is substantial, yet there are few reports evaluating the effectiveness of such training. This article reports on a follow-up survey of the first seventy-five trainees of a four-hour BRS Colleague MEDLINE training program at the Health Sciences Library of East Carolina University. The 90.7 percent response rate to the questionnaire provided information about both those who performed searches and those who had not. It indicated how trainees felt about their training, their ability to perform searches or reason for not performing searches, and types of additional training the trainees desired. Survey results are discussed in terms of effectiveness of the training for the end user with infrequent search needs, possible modifications to improve the effectiveness of the training, and possible alternatives to BRS Colleague MEDLINE. PMID:10303160

Bredderman, P J; Wojcik, J; Flake, D

1988-01-01

135

Extracting Semantic Predications from Medline Citations for Pharmacogenomics  

Microsoft Academic Search

We describe a natural language processing system (Enhanced SemRep) to identify core assertions on pharmacogenomics in Medline citations. Extracted information is represented as semantic predications covering a range of relations relevant to this domain. The specific relations addressed by the system provide greater precision than that achievable with methods that rely on entity co-occurrence. The development of Enhanced SemRep is

Caroline B. Ahlers; Marcelo Fiszman; Dina Demner-fushman; François-michel Lang; Thomas C. Rindflesch

2007-01-01

136

MedlinePlus FAQ: Can I play tutorials and videos on my mobile device?  

MedlinePLUS

... Tools ESPAÑOL Question: Can I play tutorials and videos on my mobile device? To use the sharing ... this page, please enable JavaScript. Answer: MedlinePlus has video content in different formats. MedlinePlus also links to ...

137

Seasonal Allergy Research at NIH | NIH MedlinePlus the Magazine  

MedlinePLUS

... this page please turn Javascript on. Feature: Managing Allergies Seasonal Allergy Research at NIH Past Issues / Spring 2013 Table of Contents To Find Out More MedlinePlus: Allergy www.nlm.nih.gov/medlineplus/allergy.html MedlinePlus: ...

138

Automated Patent Categorization and Guided Patent Search using IPC as Inspired by MeSH and PubMed  

PubMed Central

Document search on PubMed, the pre-eminent database for biomedical literature, relies on the annotation of its documents with relevant terms from the Medical Subject Headings ontology (MeSH) for improving recall through query expansion. Patent documents are another important information source, though they are considerably less accessible. One option to expand patent search beyond pure keywords is the inclusion of classification information: Since every patent is assigned at least one class code, it should be possible for these assignments to be automatically used in a similar way as the MeSH annotations in PubMed. In order to develop a system for this task, it is necessary to have a good understanding of the properties of both classification systems. This report describes our comparative analysis of MeSH and the main patent classification system, the International Patent Classification (IPC). We investigate the hierarchical structures as well as the properties of the terms/classes respectively, and we compare the assignment of IPC codes to patents with the annotation of PubMed documents with MeSH terms. Our analysis shows a strong structural similarity of the hierarchies, but significant differences of terms and annotations. The low number of IPC class assignments and the lack of occurrences of class labels in patent texts imply that current patent search is severely limited. To overcome these limits, we evaluate a method for the automated assignment of additional classes to patent documents, and we propose a system for guided patent search based on the use of class co-occurrence information and external resources. PMID:23734562

2013-01-01

139

Teaching MEDLINE to non-urban end users.  

PubMed

The University of Oklahoma Health Sciences Center (OUHSC) Library conducted a two-year program, funded by the National Library of Medicine (NLM), to teach Oklahoma's nonurban health professionals to perform searches of NLM's MEDLINE files using microcomputers. The training program included lectures, online demonstrations, and hands-on practice time. The initial target audience of non-urban physicians was later broadended to include other health professionals. Data collected on the 334 seminar participants included professions and specialties, previous microcomputer usage, and the size of their hospitals. On-site evaluation indicated a high degree of satisfaction with the trainers' communication skills, preparation, information imparted, and the visual aids used. The results of a follow-up survey to determine how many trainees subsequently obtained NLM codes, the amount of searching done, and the problems experienced await analysis. PMID:10303954

Wender, R W; Thompson, C M

1989-01-01

140

How Twitter Is Studied in the Medical Professions: A Classification of Twitter Papers Indexed in PubMed  

PubMed Central

Background Since their inception, Twitter and related microblogging systems have provided a rich source of information for researchers and have attracted interest in their affordances and use. Since 2009 PubMed has included 123 journal articles on medicine and Twitter, but no overview exists as to how the field uses Twitter in research. Objective This paper aims to identify published work relating to Twitter within the fields indexed by PubMed, and then to classify it. This classification will provide a framework in which future researchers will be able to position their work, and to provide an understanding of the current reach of research using Twitter in medical disciplines. Methods Papers on Twitter and related topics were identified and reviewed. The papers were then qualitatively classified based on the paper’s title and abstract to determine their focus. The work that was Twitter focused was studied in detail to determine what data, if any, it was based on, and from this a categorization of the data set size used in the studies was developed. Using open coded content analysis additional important categories were also identified, relating to the primary methodology, domain, and aspect. Results As of 2012, PubMed comprises more than 21 million citations from biomedical literature, and from these a corpus of 134 potentially Twitter related papers were identified, eleven of which were subsequently found not to be relevant. There were no papers prior to 2009 relating to microblogging, a term first used in 2006. Of the remaining 123 papers which mentioned Twitter, thirty were focused on Twitter (the others referring to it tangentially). The early Twitter focused papers introduced the topic and highlighted the potential, not carrying out any form of data analysis. The majority of published papers used analytic techniques to sort through thousands, if not millions, of individual tweets, often depending on automated tools to do so. Our analysis demonstrates that researchers are starting to use knowledge discovery methods and data mining techniques to understand vast quantities of tweets: the study of Twitter is becoming quantitative research. Conclusions This work is to the best of our knowledge the first overview study of medical related research based on Twitter and related microblogging. We have used 5 dimensions to categorize published medical related research on Twitter. This classification provides a framework within which researchers studying development and use of Twitter within medical related research, and those undertaking comparative studies of research, relating to Twitter in the area of medicine and beyond, can position and ground their work. PMID:25075237

2013-01-01

141

Optimal search strategies for identifying mental health content in MEDLINE: an analytic survey  

Microsoft Academic Search

OBJECTIVE: General practitioners, mental health practitioners, and researchers wishing to retrieve the best current research evidence in the content area of mental health may have a difficult time when searching large electronic databases such as MEDLINE. When MEDLINE is searched unaided, key articles are often missed while retrieving many articles that are irrelevant to the search. The objectives of this

Nancy L Wilczynski; R Brian Haynes

2006-01-01

142

A Re-Analysis of the Cochrane Library Data: The Dangers of Unobserved Heterogeneity in Meta-Analyses  

PubMed Central

Background Heterogeneity has a key role in meta-analysis methods and can greatly affect conclusions. However, true levels of heterogeneity are unknown and often researchers assume homogeneity. We aim to: a) investigate the prevalence of unobserved heterogeneity and the validity of the assumption of homogeneity; b) assess the performance of various meta-analysis methods; c) apply the findings to published meta-analyses. Methods and Findings We accessed 57,397 meta-analyses, available in the Cochrane Library in August 2012. Using simulated data we assessed the performance of various meta-analysis methods in different scenarios. The prevalence of a zero heterogeneity estimate in the simulated scenarios was compared with that in the Cochrane data, to estimate the degree of unobserved heterogeneity in the latter. We re-analysed all meta-analyses using all methods and assessed the sensitivity of the statistical conclusions. Levels of unobserved heterogeneity in the Cochrane data appeared to be high, especially for small meta-analyses. A bootstrapped version of the DerSimonian-Laird approach performed best in both detecting heterogeneity and in returning more accurate overall effect estimates. Re-analysing all meta-analyses with this new method we found that in cases where heterogeneity had originally been detected but ignored, 17–20% of the statistical conclusions changed. Rates were much lower where the original analysis did not detect heterogeneity or took it into account, between 1% and 3%. Conclusions When evidence for heterogeneity is lacking, standard practice is to assume homogeneity and apply a simpler fixed-effect meta-analysis. We find that assuming homogeneity often results in a misleading analysis, since heterogeneity is very likely present but undetected. Our new method represents a small improvement but the problem largely remains, especially for very small meta-analyses. One solution is to test the sensitivity of the meta-analysis conclusions to assumed moderate and large degrees of heterogeneity. Equally, whenever heterogeneity is detected, it should not be ignored. PMID:23922860

Kontopantelis, Evangelos; Springate, David A.; Reeves, David

2013-01-01

143

Using Citation Data to Improve Retrieval from MEDLINE  

PubMed Central

Objective: To determine whether algorithms developed for the World Wide Web can be applied to the biomedical literature in order to identify articles that are important as well as relevant. Design and Measurements A direct comparison of eight algorithms: simple PubMed queries, clinical queries (sensitive and specific versions), vector cosine comparison, citation count, journal impact factor, PageRank, and machine learning based on polynomial support vector machines. The objective was to prioritize important articles, defined as being included in a pre-existing bibliography of important literature in surgical oncology. Results Citation-based algorithms were more effective than noncitation-based algorithms at identifying important articles. The most effective strategies were simple citation count and PageRank, which on average identified over six important articles in the first 100 results compared to 0.85 for the best noncitation-based algorithm (p < 0.001). The authors saw similar differences between citation-based and noncitation-based algorithms at 10, 20, 50, 200, 500, and 1,000 results (p < 0.001). Citation lag affects performance of PageRank more than simple citation count. However, in spite of citation lag, citation-based algorithms remain more effective than noncitation-based algorithms. Conclusion Algorithms that have proved successful on the World Wide Web can be applied to biomedical information retrieval. Citation-based algorithms can help identify important articles within large sets of relevant results. Further studies are needed to determine whether citation-based algorithms can effectively meet actual user information needs. PMID:16221938

Bernstam, Elmer V.; Herskovic, Jorge R.; Aphinyanaphongs, Yindalon; Aliferis, Constantin F.; Sriram, Madurai G.; Hersh, William R.

2006-01-01

144

Systematic review of the use of honey as a wound dressing  

Microsoft Academic Search

OBJECTIVE: To investigate topical honey in superficial burns and wounds though a systematic review of randomised controlled trials. DATA SOURCES: Cochrane Library, MEDLINE, EMBASE, PubMed, reference lists and databases were used to seek randomised controlled trials. Seven randomised trials involved superficial burns, partial thickness burns, moderate to severe burns that included full thickness injury, and infected postoperative wounds. REVIEW METHODS:

Owen A Moore; Lesley A Smith; Fiona Campbell; Kate Seers; Henry J McQuay; R Andrew Moore

2001-01-01

145

The Relationship between Sugar-Containing Methadone and Dental Caries: A Systematic Review  

ERIC Educational Resources Information Center

Objectives: To review the evidence of a relationship between sugar-containing methadone and dental caries. Data sources: A systematic search of Cochrane Library, PubMed, PsychINFO, EMBASE, MEDLINE, Current Controlled Trials, WHO, OHRN, SIGLE and ERIC databases was conducted from January 1978 up to June 2010. Study selection: Articles were assessed…

Tripathee, Sheela; Akbar, Tahira; Richards, Derek; Themessl-Huber, Markus; Freeman, Ruth

2013-01-01

146

Association between Clomiphene Citrate and Visual Disturbances with Special Emphasis on Central Retinal Vein Occlusion: A Review  

Microsoft Academic Search

Objectives: To determine whether clomiphene citrate (CC) can be implicated as a cause for central retinal vein occlusion (CRVO) and other visual disturbances. Methods: For this systematic review, we performed a search of the following databases: PubMed (1976 to November 2009), Medline Plus 2009, Cochrane Library (1996 to November 2009), Google and Google Scholar (1996 to November 2009). Thirty-five relevant

Maria I. Viola; David Meyer; Thinus Kruger

2011-01-01

147

Early Childhood Dental Caries: A Rising Dental Public Health Crisis  

ERIC Educational Resources Information Center

The aim of this article is to examine the literature and review the risk factors and disparities contributing to early childhood caries (ECC), which is a major health problem among preschoolers in the United States of America. A search was conducted using MEDLINE, PubMed, Google Scholar, and the Cochrane Library databases and the key terms…

Gomez, Grace Felix

2013-01-01

148

Extracting rate changes in transcriptional regulation from MEDLINE abstracts  

PubMed Central

Background Time delays are important factors that are often neglected in gene regulatory network (GRN) inference models. Validating time delays from knowledge bases is a challenge since the vast majority of biological databases do not record temporal information of gene regulations. Biological knowledge and facts on gene regulations are typically extracted from bio-literature with specialized methods that depend on the regulation task. In this paper, we mine evidences for time delays related to the transcriptional regulation of yeast from the PubMed abstracts. Results Since the vast majority of abstracts lack quantitative time information, we can only collect qualitative evidences of time delays. Specifically, the speed-up or delay in transcriptional regulation rate can provide evidences for time delays (shorter or longer) in GRN. Thus, we focus on deriving events related to rate changes in transcriptional regulation. A corpus of yeast regulation related abstracts was manually labeled with such events. In order to capture these events automatically, we create an ontology of sub-processes that are likely to result in transcription rate changes by combining textual patterns and biological knowledge. We also propose effective feature extraction methods based on the created ontology to identify the direct evidences with specific details of these events. Our ontologies outperform existing state-of-the-art gene regulation ontologies in the automatic rule learning method applied to our corpus. The proposed deterministic ontology rule-based method can achieve comparable performance to the automatic rule learning method based on decision trees. This demonstrates the effectiveness of our ontology in identifying rate-changing events. We also tested the effectiveness of the proposed feature mining methods on detecting direct evidence of events. Experimental results show that the machine learning method on these features achieves an F1-score of 71.43%. Conclusions The manually labeled corpus of events relating to rate changes in transcriptional regulation for yeast is available in https://sites.google.com/site/wentingntu/data. The created ontologies summarized both biological causes of rate changes in transcriptional regulation and corresponding positive and negative textual patterns from the corpus. They are demonstrated to be effective in identifying rate-changing events, which shows the benefits of combining textual patterns and biological knowledge on extracting complex biological events. PMID:24564647

2014-01-01

149

Biotea: RDFizing PubMed Central in support for the paper as an interface to the Web of Data  

PubMed Central

Background The World Wide Web has become a dissemination platform for scientific and non-scientific publications. However, most of the information remains locked up in discrete documents that are not always interconnected or machine-readable. The connectivity tissue provided by RDF technology has not yet been widely used to support the generation of self-describing, machine-readable documents. Results In this paper, we present our approach to the generation of self-describing machine-readable scholarly documents. We understand the scientific document as an entry point and interface to the Web of Data. We have semantically processed the full-text, open-access subset of PubMed Central. Our RDF model and resulting dataset make extensive use of existing ontologies and semantic enrichment services. We expose our model, services, prototype, and datasets at http://biotea.idiginfo.org/ Conclusions The semantic processing of biomedical literature presented in this paper embeds documents within the Web of Data and facilitates the execution of concept-based queries against the entire digital library. Our approach delivers a flexible and adaptable set of tools for metadata enrichment and semantic processing of biomedical documents. Our model delivers a semantically rich and highly interconnected dataset with self-describing content so that software can make effective use of it. PMID:23734622

2013-01-01

150

To Compare PubMed Clinical Queries and UpToDate in Teaching Information Mastery to Clinical Residents: A Crossover Randomized Controlled Trial  

PubMed Central

Purpose To compare PubMed Clinical Queries and UpToDate regarding the amount and speed of information retrieval and users' satisfaction. Method A cross-over randomized trial was conducted in February 2009 in Tehran University of Medical Sciences that included 44 year-one or two residents who participated in an information mastery workshop. A one-hour lecture on the principles of information mastery was organized followed by self learning slide shows before using each database. Subsequently, participants were randomly assigned to answer 2 clinical scenarios using either UpToDate or PubMed Clinical Queries then crossed to use the other database to answer 2 different clinical scenarios. The proportion of relevantly answered clinical scenarios, time to answer retrieval, and users' satisfaction were measured in each database. Results Based on intention-to-treat analysis, participants retrieved the answer of 67 (76%) questions using UpToDate and 38 (43%) questions using PubMed Clinical Queries (P<0.001). The median time to answer retrieval was 17 min (95% CI: 16 to 18) using UpToDate compared to 29 min (95% CI: 26 to 32) using PubMed Clinical Queries (P<0.001). The satisfaction with the accuracy of retrieved answers, interaction with UpToDate and also overall satisfaction were higher among UpToDate users compared to PubMed Clinical Queries users (P<0.001). Conclusions For first time users, using UpToDate compared to Pubmed Clinical Querries can lead to not only a higher proportion of relevant answer retrieval within a shorter time, but also a higher users' satisfaction. So, addition of tutoring pre-appraised sources such as UpToDate to the information mastery curricula seems to be highly efficient. PMID:21858142

Sayyah Ensan, Ladan; Faghankhani, Masoomeh; Javanbakht, Anna; Ahmadi, Seyed-Foad; Baradaran, Hamid Reza

2011-01-01

151

Globetrotting to a Good Night's Sleep | NIH MedlinePlus the Magazine  

MedlinePLUS

... is one of the most common and troubling sleep disorders. At least 1 in 10 older adults, and ... have sleep apnea. To Find Out More MedlinePlus Sleep Disorders www.nlm.nih.gov/medlineplus/sleepdisorders.html NHLBI ...

152

More to Love on MedlinePlus® Mobile: A Full Version for Your Phone  

MedlinePLUS

... the matching page on the current “desktop” site. Send us your feedback on this new version We ... bottom of any page on MedlinePlus Mobile to send us feedback about the mobile site. Responsive Design ...

153

Don't Let Osteoporosis Slow You Down | NIH MedlinePlus the Magazine  

MedlinePLUS

... U.S. Congress on behalf of the Foundation and the U.S. Office on Women's Health's "Best Bones Forever" osteoporosis educational campaign. NIH MedlinePlus magazine's Peter Reinecke spoke to Leachman about her approach to ...

154

Are men difficult to find? Identifying male-specific studies in MEDLINE and Embase  

PubMed Central

Background Systematic reviews often investigate the effectiveness of interventions for one sex. However, identifying interventions with data presented according to the sex of study participants can be challenging due to suboptimal indexing in bibliographic databases and poor reporting in titles and abstracts. The purposes of this study were to develop a highly sensitive search filter to identify literature relevant to men's health and to assess the performance of a range of sex-specific search terms used individually and in various combinations. Methods Comprehensive electronic searches were undertaken across a range of databases to inform a series of systematic reviews investigating obesity management for men. The included studies formed a reference standard set. A set of sex-specific search terms, identified from database-specific controlled vocabularies and from natural language used in the titles and abstracts of relevant papers, was investigated in MEDLINE and Embase. Sensitivity, precision, number needed to read (NNR) and percent reduction in results compared to searching without sex-specific terms were calculated. Results The reference standard set comprised 57 papers in MEDLINE and 63 in Embase. Seven sex-specific search terms were identified. Searching without sex-specific terms returned 31,897 results in MEDLINE and 37,351 in Embase and identified 84% (MEDLINE) and 83% (Embase) of the reference standard sets. The best performing individual sex-specific term achieved 100%/98% sensitivity (MEDLINE/Embase), NNR 544/609 (MEDLINE/Embase) and reduced the number of results by 18%/17% (MEDLINE/Embase), relative to searching without sex-specific terms. The best performing filter, compromising different combinations of controlled vocabulary terms and natural language, achieved higher sensitivity (MEDLINE and Embase 100%), greater reduction in number of results (MEDLINE/Embase 24%/20%) and greater reduction in NNR (MEDLINE/Embase 506/578) than the best performing individual sex-specific term. Conclusions The proposed MEDLINE and Embase filters achieved high sensitivity and a reduction in the number of search results and NNR, indicating that they are useful tools for efficient, comprehensive literature searching but their performance is partially dependent on the appropriate use of database controlled vocabularies and index terms. PMID:25033713

2014-01-01

155

A Probabilistic Similarity Metric for Medline Records: A Model for Author Name Disambiguation  

PubMed Central

We present a model for automatically generating training sets and estimating the probability that a pair of Medline records sharing a last and first name initial are authored by the same individual, based on shared title words, journal name, co-authors, medical subject headings, language, and affiliation, as well as distinctive features of the name itself (i.e., presence of middle initial, suffix, and prevalence in Medline). PMID:14728536

Torvik, Vetle I.; Weeber, Marc; Swanson, Don R.; Smalheiser, Neil R.

2003-01-01

156

CoPub Mapper: mining MEDLINE based on search term co-publication  

Microsoft Academic Search

BACKGROUND: High throughput microarray analyses result in many differentially expressed genes that are potentially responsible for the biological process of interest. In order to identify biological similarities between genes, publications from MEDLINE were identified in which pairs of gene names and combinations of gene name with specific keywords were co-mentioned. RESULTS: MEDLINE search strings for 15,621 known genes and 3,731

Blaise T. F. Alako; Antoine Veldhoven; Sjozef Van Baal; Rob Jelier; Stefan Verhoeven; Ton Rullmann; Jan Polman; Guido Jenster

2005-01-01

157

Screening women for intimate partner violence in healthcare settings: abridged Cochrane systematic review and meta-analysis  

PubMed Central

Objective To examine the effectiveness of screening for intimate partner violence conducted within healthcare settings to determine whether or not screening increases identification and referral to support agencies, improves women’s wellbeing, decreases further violence, or causes harm. Design Systematic review and meta-analysis of trials assessing effectiveness of screening. Study assessment, data abstraction, and quality assessment were conducted independently by two of the authors. Standardised estimations of the risk ratios and 95% confidence intervals were calculated. Data sources Nine databases searched up to July 2012 (CENTRAL, Medline, Medline(R), Embase, DARE, CINAHL, PsycINFO, Sociological Abstracts, and ASSIA), and five trials registers searched up to 2010. Eligibility criteria for selecting studies Randomised or quasi-randomised trials of screening programmes for intimate partner violence involving all women aged ?16 attending a healthcare setting. We included only studies in which clinicians in the intervention arm personally conducted the screening, or were informed of the screening result at the time of the consultation, compared with usual care (or no screening). Studies of screening programmes that were followed by structured interventions such as advocacy or therapeutic intervention were excluded. Results 11 eligible trials (n=13?027) were identified. In six pooled studies (n=3564), screening increased the identification of intimate partner violence (risk ratio 2.33, 95% confidence interval 1.39 to 3.89), particularly in antenatal settings (4.26, 1.76 to 10.31). Based on three studies (n=1400), we detected no evidence that screening increases referrals to domestic violence support services (2.67, 0.99 to 7.20). Only two studies measured women’s experience of violence after screening (three to 18 months after screening) and found no reduction in intimate partner violence. One study reported that screening does not cause harm. Conclusions Though screening is likely to increase identification of intimate partner violence in healthcare settings, rates of identification from screening interventions were low relative to best estimates of prevalence of such violence. It is uncertain whether screening increases effective referral to supportive agencies. Screening does not seem to cause harm in the short term, but harm was measured in only one study. As the primary studies did not detect improved outcomes for women screened for intimate partner violence, there is insufficient evidence for screening in healthcare settings. Studies comparing screening versus case finding, or screening in combination with therapeutic intervention for women’s long term wellbeing, are needed to inform the implementation of identification policies in healthcare settings. PMID:24821132

2014-01-01

158

O Campo da Odontologia Social: Pesquisas Indexadas no Medline em 1997-1998 Studies on Social Dentistry: Researches Reported to the Medline Database in 1997-1998  

Microsoft Academic Search

We have surveyed through the world wide web researches published between 1997 and 1998 in scientific journals integrated to the MEDLINE database, kept by the United States National Library of Medicine. We collected 150 studies from different countries, which were performed by 337 researchers and were published in 71 journals. These studies were read and classified by several characteristics. We

José Leopoldo Ferreira Antunes; Virgínia Aparecida Trigueiro; Sirlei Pires Terra

159

Tamm-Horsfall protein in patients with kidney dama...[Urol Res. 2004] -PubMed Result Urol Res. 2004 May;32(2):79-83. Links  

E-print Network

Tamm-Horsfall protein in patients with kidney dama...[Urol Res. 2004] - PubMed Result Urol Res. 2004 May;32(2):79-83. Links Tamm-Horsfall protein in patients with kidney damage and diabetes in diabetic and control kidney tissue specimens with or without kidney damage. Immunogold labeling

Abraham, Nader G.

160

The comparative recall of Google Scholar versus PubMed in identical searches for biomedical systematic reviews: a review of searches used in systematic reviews  

PubMed Central

Background The usefulness of Google Scholar (GS) as a bibliographic database for biomedical systematic review (SR) searching is a subject of current interest and debate in research circles. Recent research has suggested GS might even be used alone in SR searching. This assertion is challenged here by testing whether GS can locate all studies included in 21 previously published SRs. Second, it examines the recall of GS, taking into account the maximum number of items that can be viewed, and tests whether more complete searches created by an information specialist will improve recall compared to the searches used in the 21 published SRs. Methods The authors identified 21 biomedical SRs that had used GS and PubMed as information sources and reported their use of identical, reproducible search strategies in both databases. These search strategies were rerun in GS and PubMed, and analyzed as to their coverage and recall. Efforts were made to improve searches that underperformed in each database. Results GS’ overall coverage was higher than PubMed (98% versus 91%) and overall recall is higher in GS: 80% of the references included in the 21 SRs were returned by the original searches in GS versus 68% in PubMed. Only 72% of the included references could be used as they were listed among the first 1,000 hits (the maximum number shown). Practical precision (the number of included references retrieved in the first 1,000, divided by 1,000) was on average 1.9%, which is only slightly lower than in other published SRs. Improving searches with the lowest recall resulted in an increase in recall from 48% to 66% in GS and, in PubMed, from 60% to 85%. Conclusions Although its coverage and precision are acceptable, GS, because of its incomplete recall, should not be used as a single source in SR searching. A specialized, curated medical database such as PubMed provides experienced searchers with tools and functionality that help improve recall, and numerous options in order to optimize precision. Searches for SRs should be performed by experienced searchers creating searches that maximize recall for as many databases as deemed necessary by the search expert. PMID:24360284

2013-01-01

161

Stem cell transplantation of matched sibling donors compared with immunosuppressive therapy for acquired severe aplastic anaemia: a Cochrane systematic review  

PubMed Central

Objectives Acquired severe aplastic anaemia is a rare and potentially fatal disease. The aim of this Cochrane review was to evaluate the effectiveness and adverse events of first-line allogeneic haematopoietic stem cell transplantation of human leucocyte antigen (HLA)-matched sibling donors compared with first-line immunosuppressive therapy. Setting Specialised stem cell transplantations units in primary care hospitals. Participants We included 302 participants with newly diagnosed acquired severe aplastic anaemia. The age ranged from early childhood to young adulthood. We excluded studies on participants with secondary aplastic anaemia. Interventions We included allogeneic haematopoietic stem cell transplantation as the test intervention harvested from any source of matched sibling donor and serving as a first-line therapy. We included immunosuppressive therapy as comparator with either antithymocyte/antilymphocyte globulin or ciclosporin or a combination of the two. Primary and secondary outcome measures planned and finally measured The primary outcome was overall mortality. Secondary outcomes were treatment-related mortality, graft failure, graft-versus-host disease, no response to immunosuppressive therapy, relapse after initial successful treatment, secondary clonal disease or malignancies, health-related quality of life and performance scores. Results We identified three prospective non-randomised controlled trials with a study design that was consistent with the principle of ‘Mendelian randomisation’ in allocating patients to treatment groups. All studies had a high risk of bias due to the study design and were conducted more than 15?years. The pooled HR for overall mortality for the donor group versus the no donor group was 0.95 (95% CI 0.43 to 2.12, p=0.90). Conclusions There are insufficient and biased data that do not allow any firm conclusions to be made about the comparative effectiveness of first-line allogeneic haematopoietic stem cell transplantation of HLA-matched sibling donors and first-line immunosuppressive therapy of patients with acquired severe aplastic anaemia. PMID:25031191

Peinemann, Frank; Labeit, Alexander Michael

2014-01-01

162

Still too little qualitative research to shed light on results from reviews of effectiveness trials: A case study of a Cochrane review on the use of lay health workers  

PubMed Central

Background Qualitative research is used increasingly alongside trials of complex interventions to explore processes, contextual factors, or intervention characteristics that may have influenced trial outcomes. Qualitative research conducted alongside trials can also be used to shed light on the results of systematic reviews of effectiveness by looking for factors that can help explain heterogeneous results across trials. In a Cochrane review on the effects of using lay health workers on maternal and child health and infectious disease control, we identified 82 trials. These trials showed promising benefits but results were heterogeneous. Objective To use qualitative studies conducted alongside these trials to explore factors and processes that might have influenced intervention outcomes. Methods We attempted to identify qualitative research carried out alongside the trials by contacting trial authors, checking papers for references to qualitative research, searching Pubmed for related studies, and carrying out citation searches. For those qualitative studies that we included, we extracted information regarding study objective, data collection and analysis methods, and key themes and categories. Results For 52 (63%) of the trials, we found no qualitative research that had been conducted alongside the trials. For 16 (20%) trials, some form of qualitative data collection had been done but was unavailable or had been done before the trial. For 14 (17%) trials, qualitative research had been done during or shortly after the trial, although descriptions of qualitative methods and results were often sparse. Most of these 14 studies aimed to elicit trial participants' perspectives and experiences of the intervention. A common theme was participants' appreciation of the lay health workers' shared circumstances, for instance with regard to social background or experience of the health condition. In six studies, researchers explored the experiences of the lay health workers themselves. Issues included the importance of regular supervision and health professionals' support or lack of support. Conclusions Qualitative studies carried out alongside trials of complex interventions could offer opportunities to authors of systematic reviews of effectiveness wishing to understand the heterogeneity of trial results. For interventions of lay health worker programmes at least, too few such studies exist at present for these opportunities to be realised. PMID:21619645

2011-01-01

163

An evaluation of four end-user systems for searching MEDLINE.  

PubMed Central

This study compared features and determined which of four end-user systems (PaperChase, GRATEFUL MED, Med-Base, or Compact Cambridge: MEDLINE) would best serve the Medical Sciences and Optometry Libraries of Indiana University in providing biomedical information to faculty and graduate students through MEDLINE. Cost, ease of use, retrieval, training needs, equipment requirements, and adequacy of documentation were examined. The study consisted of a comparison of the features of each system based on available documentation; a controlled search performed by the investigators on each system and on regular NLM MEDLINE; and a user study based on observations, questionnaires, and interviews with eleven library patrons who performed the same search of their choice on each of the four systems. PMID:3285928

Bonham, M D; Nelson, L L

1988-01-01

164

An evaluation of four end-user systems for searching MEDLINE.  

PubMed Central

This study compared features and determined which of four end-user systems (PaperChase, GRATEFUL MED, Med-Base, or Compact Cambridge: MEDLINE) would best serve the Medical Sciences and Optometry Libraries of Indiana University in providing biomedical information to faculty and graduate students through MEDLINE. Cost, ease of use, retrieval, training needs, equipment requirements, and adequacy of documentation were examined. The study consisted of a comparison of the features of each system based on available documentation; a controlled search performed by the investigators on each system and on regular NLM MEDLINE; and a user study based on observations, questionnaires, and interviews with eleven library patrons who performed the same search of their choice on each of the four systems. PMID:3285938

Bonham, M D; Nelson, L L

1988-01-01

165

A network meta-analysis of randomized controlled trials of biologics for rheumatoid arthritis: a Cochrane overview  

PubMed Central

Background We sought to compare the benefits and safety of 6 biologics (abatacept, adalimumab, anakinra, etanercept, infliximab and rituximab) in patients with rheumatoid arthritis. Methods In this network meta-analysis, we included all completed and updated Cochrane reviews on biologics for rheumatoid arthritis. We included data from all placebo-controlled trials that used standard dosing regimens. The major outcomes were benefit (defined as a 50% improvement in patient- and physician-reported criteria of the American College of Rheumatology [ACR50]) and safety (determined by the number of withdrawals related to adverse events). We used mixed-effects logistic regression to carry out an indirect comparison of the treatment effects between biologics. Results Compared with placebo, biologics were associated with a clinically important higher ACR50 rate (odds ratio [OR] 3.35, 95% confidence interval [CI] 2.62–4.29) and a number needed to treat for benefit of 4 (95% CI 4–6). However, biologics were associated with more withdrawals related to adverse events (OR 1.39, 95% CI 1.13–1.71), with a number needed to treat for harm of 52 (95% CI 29–152). Anakinra was less effective than all of the other biologics, although this difference was statistically significant only for the comparison with adalimumab (OR 0.45, 95% CI 0.21–0.99) and etanercept (OR 0.34, 95% CI 0.14–0.81). Adalimumab, anakinra and infliximab were more likely than etanercept to lead to withdrawals related to adverse events (adalimumab OR 1.89, 95% CI 1.18–3.04; anakinra OR 2.05, 95% CI 1.27–3.29; and infliximab OR 2.70, 95% CI 1.43–5.26). Interpretation Given the limitations of indirect comparisons, anakinra was less effective than adalimumab and etanercept, and etanercept was safer than adalimumab, anakinra and infliximab. This summary of the evidence will help physicians and patients to make evidence-based choices about biologics for the treatment of rheumatoid arthritis. PMID:19884297

Singh, Jasvinder A.; Christensen, Robin; Wells, George A.; Suarez-Almazor, Maria E.; Buchbinder, Rachelle; Lopez-Olivo, Maria Angeles; Ghogomu, Elizabeth Tanjong; Tugwell, Peter

2009-01-01

166

Mining MEDLINE: Postulating a Beneficial Role for Curcumin Longa in Retinal Diseases  

E-print Network

Mining MEDLINE: Postulating a Beneficial Role for Curcumin Longa in Retinal Diseases Padmini supporting the suggested connection between curcumin and retinal diseases. In particular, curcumin influ, the evidence suggests that curcumin may have a beneficial and therapeutic role in the context of these dis

Srinivasan, Padmini

167

Parkinson's Disease Research at NIH | NIH MedlinePlus the Magazine  

MedlinePLUS

... of this page please turn JavaScript on. Feature: Parkinson's Disease Parkinson's Disease Research at NIH Past Issues / Winter 2014 ... of its research: MedlinePlus . www.medlineplus.gov . Type "Parkinson's disease" in the Search box. NIHSeniorHealth —Parkinson's Disease ...

168

Married...with Food Allergies | NIH MedlinePlus the Magazine  

MedlinePLUS

... this page please turn Javascript on. Feature: Food Allergies Married...with Food Allergies Past Issues / Spring 2011 Table of Contents Photo: ... life together and a common problem—severe food allergies. NIH MedlinePlus magazine’s Naomi Miller caught up with ...

169

A probabilistic similarity metric for Medline records: A model for author name disambiguation  

Microsoft Academic Search

We present a model for estimating the probability that a pair of author names (sharing last name and first initial), appearing on two different Medline articles, refer to the same individual. The model uses a simple yet powerful similarity profile between a pair of articles, based on title, journal name, coauthor names, medical subject headings (MeSH), language, affiliation, and name

Vetle I. Torvik; Marc Weeber; Don R. Swanson; Neil R. Smalheiser

2005-01-01

170

A rule-based approach for automatically identifying gene and protein names in MEDLINE abstracts  

E-print Network

Identifying gene and protein terms is important for obtaining biological knowledge from literature. We have developed GPmarkup (for gene and proteinname mark up), a system that automatically identifies gene and protein terms and maps gene and protein symbols (e.g., DR3) to names (e.g., Death Receptor 3) in MEDLINE abstracts.

Hong Yu Vasileios; Hong Yu; Vasileios Hatzivassiloglou; Carol Friedman; Ivan H. Iossifov; Andrey Rzhetsky

2002-01-01

171

Subject Indexing of the American Journal of Occupational Therapy in MEDLINE and NAHL  

Microsoft Academic Search

Rehabilitation professionals need access to current journal literature for research and patient care. Using the American Journal of Occupational Therapy, subject headings from MEDLINE and NAHL files are compared to determine coincidence and numbers of headings. Based on the study findings, an information retrieval plan is suggested taht librarians may use in assisting rehabilitation personnel in effective use of Index

Phyllis S. Lansing; Margaret E. Edmondson

1987-01-01

172

Where should the pharmacy researcher look first? Comparing International Pharmaceutical Abstracts and MEDLINE.  

PubMed Central

This study compared the usefulness of various CD-ROM versions of International Pharmaceutical Abstracts (IPA) and MEDLINE for pharmacy research. Journal coverage as well as the strengths and weaknesses of database structure and contents were considered. The journals indexed in each database were compared to those identified in a survey of the research journals most important to University of Maryland at Baltimore pharmacy faculty and in a similar North Carolina study rating pharmacy journals. In addition, indexed journals were checked against the Institute for Scientific Information's most recent list of high-impact journals in pharmacology and pharmacy. Searches representing a variety of topics relevant to pharmacy were conducted in both databases, and the number and relevance of citations located were analyzed. Results showed that IPA indexed a greater number of pharmacy titles, but that MEDLINE indexed more pharmacy journals designated in studies as significant to the field. There was little overlap in coverage between the two databases. MEDLINE produced larger retrievals for the majority of questions, but many citations retrieved in IPA did not appear in MEDLINE. PMID:8883989

Fishman, D L; Stone, V L; DiPaula, B A

1996-01-01

173

MedlinePlus® Go Local Programs: A Review of the Literature  

Microsoft Academic Search

MedlinePlus® is a premier consumer health portal. Developed by the National Library of Medicine in the late 1990s, this site added Go Local projects, beginning in 2003 with NC Health Info, to make information about facilities, providers, and services available at the local level. This article documents the literature about the Go Local programs.

M. Sandra Wood

2009-01-01

174

Optimal search strategies for detecting health services research studies in MEDLINE  

Microsoft Academic Search

Background: Evidence from health services research (HSR) is cur- rently thinly spread through many journals, making it difficult for health services researchers, managers and policy-makers to find research on clinical practice guidelines and the appropri- ateness, process, outcomes, cost and economics of health care services. We undertook to develop and test search terms to re- trieve from the MEDLINE database

Nancy L. Wilczynski; R. Brian Haynes; John N. Lavis; Alexandra E. Arnold-Oatley

175

Extraction of Conditional Probabilities of the Relationships Between Drugs, Diseases, and Genes from PubMed Guided by Relationships in PharmGKB  

PubMed Central

Guided by curated associations between genes, treatments (i.e., drugs), and diseases in pharmGKB, we constructed n-way Bayesian networks based on conditional probability tables (cpt’s) extracted from co-occurrence statistics over the entire Pubmed corpus, producing a broad-coverage analysis of the relationships between these biological entities. The networks suggest hypotheses regarding drug mechanisms, treatment biomarkers, and/or potential markers of genetic disease. The cpt’s enable Trio, an inferential database, to query indirect (inferred) relationships via an SQL-like query language. PMID:21347183

Theobald, Martin; Shah, Nigam; Shrager, Jeff

2009-01-01

176

Developing Optimal Search Strategies for Detecting Clinically Sound Studies in MEDLINE  

Microsoft Academic Search

ObjectiveTo develop optimal MEDLINE search strategies for retrieving sound clinical studies of the etiology, prognosis, diagnosis, prevention, or treatment of disorders in adult general medicine.DesignAnalytic survey of operating characteristics of search strategies developed by computerized combinations of terms selected to detect studies meeting basic methodologic criteria for direct clinical use in adult general medicine.MeasuresThe sensitivities, specificities, precision, and accuracy of

R Brian Haynes; Nancy Wilczynski; K Ann McKibbon; Cynthia J Walker; JC Sinclair

1994-01-01

177

A Performance and Failure Analysis of SAPHIRE with a MEDLINE Test Collection  

Microsoft Academic Search

ObjectiveAssess the performance of the SAPHIRE automated information retrieval system.DesignComparative study of automated and human searching of a MEDLINE test collection.MeasurementsRecall and precision of SAPHIRE were compared with those attributes of novice physicians, expert physicians, and librarians for a test collection of 75 queries and 2,334 citations. Failure analysis assessed the efficacy of the Metathesaurus as a concept vocabulary; the

William R. Hersh; David H. Hickman; R Brian Haynes; K. Ann Mckibbon

1994-01-01

178

Optimal search strategies for detecting health services research studies in MEDLINE  

PubMed Central

Background Evidence from health services research (HSR) is currently thinly spread through many journals, making it difficult for health services researchers, managers and policy-makers to find research on clinical practice guidelines and the appropriateness, process, outcomes, cost and economics of health care services. We undertook to develop and test search terms to retrieve from the MEDLINE database HSR articles meeting minimum quality standards. Methods The retrieval performance of 7445 methodologic search terms and phrases in MEDLINE (the test) were compared with a hand search of the literature (the gold standard) for each issue of 68 journal titles for the year 2000 (a total of 25 936 articles). We determined sensitivity, specificity and precision (the positive predictive value) of the MEDLINE search strategies. Results A majority of the articles that were classified as outcome assessment, but fewer than half of those in the other categories, were considered methodologically acceptable (no methodologic criteria were applied for cost studies). Combining individual search terms to maximize sensitivity, while keeping specificity at 50% or more, led to sensitivities in the range of 88.1% to 100% for several categories (specificities ranged from 52.9% to 97.4%). When terms were combined to maximize specificity while keeping sensitivity at 50% or more, specificities of 88.8% to 99.8% were achieved. When terms were combined to maximize sensitivity and specificity while minimizing the differences between the 2 measurements, most strategies for HSR categories achieved sensitivity and specificity of at least 80%. Interpretation Sensitive and specific search strategies were validated for retrieval of HSR literature from MEDLINE. These strategies have been made available for public use by the US National Library of Medicine at www.nlm.nih.gov/nichsr/hedges/search.html. PMID:15534310

Wilczynski, Nancy L.; Haynes, R. Brian; Lavis, John N.; Ramkissoonsingh, Ravi; Arnold-Oatley, Alexandra E.

2004-01-01

179

Optimal search strategies for identifying mental health content in MEDLINE: an analytic survey  

PubMed Central

Objective General practitioners, mental health practitioners, and researchers wishing to retrieve the best current research evidence in the content area of mental health may have a difficult time when searching large electronic databases such as MEDLINE. When MEDLINE is searched unaided, key articles are often missed while retrieving many articles that are irrelevant to the search. The objectives of this study were to develop optimal search strategies to detect articles with mental health content and to determine the effect of combining mental health content search strategies with methodologic search strategies calibrated to detect the best studies of treatment. Method An analytic survey was conducted, comparing hand searches of 29 journals with retrievals from MEDLINE for 3,395 candidate search terms and 11,317 combinations. The sensitivity, specificity, precision, and accuracy of the search strategies were calculated. Results 3,277 (26.8%) of the 12,233 articles classified in the 29 journals were considered to be of interest to the discipline area of mental health. Search term combinations reached peak sensitivities of 98.4% with specificity at 50.0%, whereas combinations of search terms to optimize specificity reached peak specificities of 97.1% with sensitivity at 51.7%. Combining content search strategies with methodologic search strategies for treatment led to improved precision: substantive decreases in the number of articles that needed to be sorted through in order to find target articles. Conclusion Empirically derived search strategies can achieve high sensitivity and specificity for retrieving mental health content from MEDLINE. Combining content search strategies with methodologic search strategies led to more precise searches. PMID:16556313

Wilczynski, Nancy L; Haynes, R Brian

2006-01-01

180

MedlinePlus and the challenge of low health literacy: findings from the Colonias project*  

PubMed Central

Objective: To explore the potential of a community-based health information outreach project to overcome problems associated with health literacy in low-income Hispanic communities along the Texas-Mexico border. Methods: Using a train-the-trainer approach, community outreach workers known as promotoras were trained by a health information outreach team to search English and Spanish versions of MedlinePlus. These 15 promotoras submitted written examples on a weekly basis of the topics they helped residents explore on MedlinePlus and the ways in which the residents used the information. These weekly reports, along with verbal interviews with promotoras and others in the communities, allowed development of a database of 161 incidents (“stories”) demonstrating how community residents used MedlinePlus. These stories were thematically analyzed to explore how the program benefited participants. Results: The database of stories included examples of community residents becoming better informed about their illnesses, resolving to visit doctors, making decisions about recommended treatments, reducing their anxiety about health conditions, committing to healthy or preventive behavior, and assisting family members. Conclusion: With the help of paraprofessionals like promotoras, community-based health information outreach projects may improve the ability of community residents to understand their health conditions and to participate actively in their health care. PMID:17252064

Olney, Cynthia A.; Warner, Debra G.; Reyna, Greysi; Wood, Fred B.; Siegel, Elliot R.

2007-01-01

181

A survey of scientific production and collaboration rate among of medical library and information sciences in ISI, scopus and Pubmed databases during 2001-2010  

PubMed Central

Background: Research is essential for development. In other words, scientific development of each country can be evaluated by researchers’ scientific production. Understanding and assessing the activities of researchers for planning and policy making is essential. The significance of collaboration in the production of scientific publications in today's complex world where technology is everything is very apparent. Scientists realized that in order to get their work wildly used and cited to by experts, they must collaborate. The collaboration among researchers results in the development of scientific knowledge and hence, attainment of wider information. The main objective of this research is to survey scientific production and collaboration rate in philosophy and theoretical bases of medical library and information sciences in ISI, SCOPUS, and Pubmed databases during 2001-2010. Materials and Methods: This is a descriptive survey and scientometrics methods were used for this research. Then data gathered via check list and analyzed by the SPSS software. Collaboration rate was calculated according to the formula. Results: Among the 294 related abstracts about philosophy, and theoretical bases of medical library and information science in ISI, SCOPUS, and Pubmed databases during 2001-2010, the year 2007 with 45 articles has the most and the year 2003 with 16 articles has the least number of related collaborative articles in this scope. “B. Hjorland” with eight collaborative articles had the most one among Library and Information Sciences (LIS) professionals in ISI, SCOPUS, and Pubmed. Journal of Documentation with 29 articles and 12 collaborative articles had the most related articles. Medical library and information science challenges with 150 articles had first place in number of articles. Results also show that the most elaborative country in terms of collaboration point of view and number of articles was US. “University of Washington” and “University Western Ontario” are the most elaborative affiliation from a collaboration point. Conclusion: The average collaboration rate between researchers in this field during the years studied is 0.25. The most completive reviewed articles are single authors that included 60.54% of the whole articles. Only 30.46% of articles were provided with two or more than two authors. PMID:24251283

Yousefy, Alireza; Malekahmadi, Parisa

2013-01-01

182

Testing the new technology: MEDLINE on CD-ROM in an academic health sciences library.  

PubMed

The UCLA Biomedical Library tested a six-month portion of the MEDLINE database on compact disc to determine its potential application in a large, university health sciences library environment. Patron response to the system, previous search experience, and actual search strategies were recorded. Although the overwhelming user response was positive in spite of little previous experience with online searching, results show underutilization of the system because of both software and hardware problems. The implications of this test underline the important role libraries must take in guaranteeing that new reference tools like CD-ROM be made genuinely user-friendly. PMID:10302195

Glitz, B

1988-01-01

183

Completeness of reporting of setting and health worker cadre among trials on antenatal iron and folic acid supplementation in pregnancy: an assessment based on two Cochrane reviews  

PubMed Central

Background Poor reporting of medical trials has triggered the development of trial reporting standards within the scientific community. In addition to a description of the proposed intervention, adequate information about the trial setting and the group of health workers (cadre) delivering the intervention would allow a better understanding of the generalizability of the trial findings, facilitate replication of trial interventions and assist with assessment of trials for inclusion in systematic reviews. This study aims to determine the completeness of reporting for trial setting and cadre among trials included in two Cochrane reviews on iron and folic acid supplementation for women during pregnancy. Methods From the 81 trials included in the two Cochrane reviews, we extracted data on the trial setting, including the facility type and geographic location, facility descriptors (i.e. level of care) and population descriptors (i.e. socioeconomic status); and the cadre, including professional qualifications, training and supervision. Results Almost all studies reported the facility type and location (96%). However, only 68% included this information in the “methods” section of the report. Facility descriptors and population descriptors were less commonly reported (26% and 54% respectively). For 34% of the trials, we found some account of the type of health worker that delivered the intervention. Only 4% of the trials reported any training procedures. Conclusions Currently, complete reporting of setting and health worker cadre in iron and folic acid supplementation in pregnancy trials remains far from ideal, limiting assessments of the applicability of the trial findings. Trialists and journals need to ensure that this information is included in trial reports by adhering to and improving current reporting standards and by not making assumptions regarding readers’ knowledge of the context and of the intervention delivery mechanism. PMID:23773404

2013-01-01

184

Being there: the effect of the user's presence on MEDLINE search results.  

PubMed

An evaluation was conducted at the University of Iowa Health Sciences Library to determine what effect the user's presence had on MEDLINE search results. One hundred users participated over a four-month period. Three main criteria were used: search precision, search recall, and user satisfaction. Each MEDLINE search was processed twice, once prior to the user's arrival and a second time during the scheduled appointment with the user. The two searches for each user were processed by different searchers, and four searchers alternated processing the user-absent or the user-present search. Users were asked to compare the citations on the two searchers by checking each printout for relevant citations. A short questionnaire was administered to determine general information about users and satisfaction measures for each search. The extensiveness of the interview for the user-absent search was varied in order to determine if the depth of the initial interview would affect the search results. Evaluation of the findings indicated an increase in precision, recall, and user satisfaction for the user-present search. Some difficulties in designing the experiment are discussed and implications of the evaluation results are considered. PMID:7052165

Morris, R T; Holtum, E A; Curry, D S

1982-07-01

185

Pharmacokinetic Interactions of Drugs with St John’s Wort  

Microsoft Academic Search

There is a worldwide increasing use of herbs which are often administered in combination with therapeutic drugs, raising the potential for herb-drug interactions. St John’s wort (Hypericum perforatum) is one of the most commonly used herbal antidepressants. A literature search was performed using Medline (via Pubmed), Biological Abstracts, Cochrane Library, AMED, PsycINFO and Embase (all from their inception to September

Shufeng Zhou; Eli Chan; Shen-Quan Pan; Min Huang; Edmund Jon Deoon Lee

2004-01-01

186

The effectiveness of walking as an intervention for low back pain: a systematic review  

Microsoft Academic Search

As current low back pain (LBP) guidelines do not specifically advocate walking as an intervention, this review has explored\\u000a for the effectiveness of walking in managing acute and chronic LBP. CINAHL, Medline, AMED, EMBASE, PubMed, Cochrane and Scopus\\u000a databases, as well as a hand search of reference lists of retrieved articles, were searched. The search was restricted to\\u000a studies in

P. Hendrick; A. M. Te Wake; A. S. Tikkisetty; L. Wulff; C. Yap; S. Milosavljevic

2010-01-01

187

Technical aspects of the cesarean section  

Microsoft Academic Search

The aim of this study was to evaluate every part of the surgical procedure during cesarean section (CS) to prevent complications\\u000a and improve the clinical outcome. We researched on PubMed, Medline, and Cochrane. The evidence-based research suggests a transverse\\u000a incision of the skin, blunt dissection of the subcutaneous tissue, omission of the bladder flap, blunt extension of the hysterotomy,\\u000a prophylactic

Daniele Bolla; Andrea Schöning; Gero Drack; René Hornung

2010-01-01

188

Effects of aquatic interventions in children with neuromotor impairments: a systematic review of the literature  

Microsoft Academic Search

Objective: To determine the effectiveness of aquatic interventions in children with neuromotor impairments.Design: A search of electronic databases that included MEDLINE, PubMed, ERIC, PsychLit, PEDro, Sport Discus, CINAHL and Cochrane between 1966 and January 2005 was conducted using the following keywords: ‘hydrotherapy’, ‘aquatic therapy’, ‘water exercise’, ‘aquatics’, ‘adapted aquatics’, ‘aquatic exercise’ and ‘swimming’. An additional resource, the Aquatic Therapy Research

Miriam Getz; Yeshayahu Hutzler; Adri Vermeer

2006-01-01

189

The effectiveness of hydrotherapy in the management of fibromyalgia syndrome: a systematic review  

Microsoft Academic Search

Hydrotherapy is often used in the treatment of fibromyalgia syndrome (FMS), however there has been limited evaluation of its\\u000a effectiveness. The aim of this systematic review was therefore to examine the effectiveness of hydrotherapy in the management\\u000a of FMS. AMED, BNI, CINAHL, The Cochrane Library, EMBASE, MEDLINE, ProQuest, PubMed, Science Direct and Web of Science were\\u000a searched (1990–July 2006). Key

Joseph G. McVeigh; Helen McGaughey; Melissa Hall; Patricia Kane

2008-01-01

190

Needling therapies in the management of myofascial trigger point pain: A systematic review  

Microsoft Academic Search

Cummings TM, White AR. Needling therapies in the management of myofascial trigger point pain: a systematic review. Arch Phys Med Rehabil 2001;82:986-92. Objective: To establish whether there is evidence for or against the efficacy of needling as a treatment approach for myofascial trigger point pain. Data Sources: PubMed, Ovid MEDLINE, Ovid EMBASE, the Cochrane Library, AMED, and CISCOM databases, searched

T. Michael Cummings; Adrian R. White

2001-01-01

191

Sedative hypnotics in older people with insomnia: meta-analysis of risks and benefits  

Microsoft Academic Search

Objectives To quantify and compare potential benefits (subjective reports of sleep variables) and risks (adverse events and morning-after psychomotor impairment) of short term treatment with sedative hypnotics in older people with insomnia. Data sources Medline, Embase, the Cochrane clinical trials database, PubMed, and PsychLit, 1966 to 2003; bibliographies of published reviews and meta-analyses; manufacturers of newer sedative hypnotics (zaleplon, zolpidem,

Jennifer Glass; Krista L Lanctôt; Nathan Herrmann; Beth A Sproule; Usoa E Busto

2005-01-01

192

Limited evidence that acupuncture is effective for treating temporomandibular disorders  

Microsoft Academic Search

Data sourcesMedline, PubMed, The Cochrane Library 2010, CINAHL, Embase, seven Korean Medical Databases and a Chinese Medical Database (China Academic Journal, www.cnki.co.kr).Study selectionParallel or cross-over RCTs that assessed the efficacy of acupuncture regardless of blinding, language and type of reporting published in English, Chinese and Korean were included. Dissertations and abstracts were included provided they contained sufficient detail. Complex interventions

Jens C Türp

2011-01-01

193

Best Practice Updates for Pediatric\\/Adolescent Weight Loss Surgery  

Microsoft Academic Search

The objective of this study is to update evidence-based best practice guidelines for pediatric\\/adolescent weight loss surgery (WLS). We performed a systematic search of English-language literature on WLS and pediatric, adolescent, gastric bypass, laparoscopic gastric banding, and extreme obesity published between April 2004 and May 2007 in PubMed, MEDLINE, and the Cochrane Library. Keywords were used to narrow the search

Janey S. A. Pratt; Carine M. Lenders; Emily A. Dionne; Alison G. Hoppin; George L. K. Hsu; Thomas H. Inge; David F. Lawlor; Margaret F. Marino; Alan F. Meyers; Jennifer L. Rosenblum; Vivian M. Sanchez

2009-01-01

194

Adrenergic-?2 receptor polymorphism and athletic performance  

Microsoft Academic Search

The focus of this review is to evaluate the influence of ?2-adrenergic receptor (ADRB2) polymorphism on human physiological function and in turn on athletic performance. A narrative review is conducted on available literature using MedLine, Pubmed and the Cochrane Library to document the location and function of ADRB2 receptors, and specifically to address the influence of genetic polymorphisms on cardiovascular,

Vishnu Sarpeshkar; David J Bentley

2010-01-01

195

An open source infrastructure for managing knowledge and finding potential collaborators in a domain-specific subset of PubMed, with an example from human genome epidemiology  

PubMed Central

Background Identifying relevant research in an ever-growing body of published literature is becoming increasingly difficult. Establishing domain-specific knowledge bases may be a more effective and efficient way to manage and query information within specific biomedical fields. Adopting controlled vocabulary is a critical step toward data integration and interoperability in any information system. We present an open source infrastructure that provides a powerful capacity for managing and mining data within a domain-specific knowledge base. As a practical application of our infrastructure, we presented two applications – Literature Finder and Investigator Browser – as well as a tool set for automating the data curating process for the human genome published literature database. The design of this infrastructure makes the system potentially extensible to other data sources. Results Information retrieval and usability tests demonstrated that the system had high rates of recall and precision, 90% and 93% respectively. The system was easy to learn, easy to use, reasonably speedy and effective. Conclusion The open source system infrastructure presented in this paper provides a novel approach to managing and querying information and knowledge from domain-specific PubMed data. Using the controlled vocabulary UMLS enhanced data integration and interoperability and the extensibility of the system. In addition, by using MVC-based design and Java as a platform-independent programming language, this system provides a potential infrastructure for any domain-specific knowledge base in the biomedical field. PMID:17996092

Yu, Wei; Yesupriya, Ajay; Wulf, Anja; Qu, Junfeng; Khoury, Muin J; Gwinn, Marta

2007-01-01

196

Impact of a low-intensity pedagogical model for integrating MedlinePlus exercises into middle school nutrition lessons*†  

PubMed Central

Objective: The research developed and pilot-tested MedlinePlus exercises in a diet-related chronic disease prevention (DCDP) middle school lesson unit called “Live.” Methods: MedlinePlus exercises were jointly developed by two middle school family and consumer sciences (FCS) teachers and integrated into the “Live” DCDP lesson unit. FCS classes (n = 4) who had participated in a prior “Live” study were chosen to pilot-test the MedlinePlus-supplemented exercises. Evaluation measures included student satisfaction (assessed using an 8-item pre- and posttest questionnaire), knowledge gained, and attitudinal changes (assessed with an abridged version of a previously developed “Live” questionnaire). Statistical analyses were performed using SPSS. Results: Of 62 total study participants, 56 (92.3%) said that they were either “somewhat” or “clearly”: (a) more likely to use MedlinePlus as a future source for answering questions about their personal health and (b) more knowledgeable about how eating habits can help prevent disease. Selected parameters were improved for nutrition knowledge (P < 0.01) and attitudes (P < 0.01) related to healthy eating. Conclusions: MedlinePlus has good potential for efficiently communicating trustworthy diet-related disease-prevention behaviors to adolescents in an existing classroom curriculum. PMID:17971886

Rankins, Jenice; Kirksey, Otis; Bogan, Yolanda; Brown, Betty

2007-01-01

197

How much do you need: a randomised experiment of whether readers can understand the key messages from summaries of Cochrane Reviews without reading the full review  

PubMed Central

Objective We explored whether readers can understand key messages without having to read the full review, and if there were differences in understanding between various types of summary. Design A randomised experiment of review summaries which compared understanding of a key outcome. Participants Members of university staff (n?=?36). Setting Universities on the island of Ireland. Method The Cochrane Review chosen examines the health impacts of the use of electric fans during heat waves. Participants were asked their expectation of the effect these would have on mortality. They were then randomly assigned a summary of the review (i.e. abstract, plain language summary, podcast or podcast transcription) and asked to spend a short time reading/listening to the summary. After this they were again asked about the effects of electric fans on mortality and to indicate if they would want to read the full Review. Main outcome measure Correct identification of a key review outcome. Results Just over half (53%) of the participants identified its key message on mortality after engaging with their summary. The figures were 33% for the abstract group, 50% for both the plain language and transcript groups and 78% for the podcast group. Conclusions The differences between the groups were not statistically significant but suggest that the audio summary might improve knowledge transfer compared to written summaries. These findings should be explored further using a larger sample size and with other reviews. PMID:25341445

Clarke, Mike

2014-01-01

198

Citation: Smyth, G. K., Yang, Y.-H., Speed, T. P. (2003). Statistical issues in cDNA microarray data analysis. Methods in Molecular Biology 224, 111-136. [PubMed ID 12710670  

E-print Network

data analysis. Methods in Molecular Biology 224, 111-136. [PubMed ID 12710670] Statistical Issues in cCitation: Smyth, G. K., Yang, Y.-H., Speed, T. P. (2003). Statistical issues in cDNA microarray Institute of Medical Research 2. Department of Statistics, University of California, Berkeley Address

Smyth, Gordon K.

199

HIV/AIDS knowledge among female migrant farm worke...[J Immigr Health. 2003] -PubMed Result 1: J Immigr Health. 2003 Jan;5(1):29-36. Links  

E-print Network

HIV/AIDS knowledge among female migrant farm worke...[J Immigr Health. 2003] - PubMed Result 1: J Immigr Health. 2003 Jan;5(1):29-36. Links HIV/AIDS knowledge among female migrant farm workers of Ohio, Toledo, Ohio 43614-5809, USA. The rate of HIV infection in the migrant farm worker community

Abraham, Nader G.

200

Automated Knowledge Extraction from MEDLINE Citations Eneida A. Mendona, M.D., James J. Cimino, M.D.  

E-print Network

in MEDLINE citations associated with the search strategies optimal for evidence-based medicine to automate. The process described above is analogous to the first step in the practice of evidence-based medicine.12 Evidence­based medicine (EBM) focuses on questions related to the central tasks of clinical work: diagnosis

Cimino, James J.

201

Quality of reporting of complex healthcare interventions and applicability of the CReDECI list - a survey of publications indexed in PubMed  

PubMed Central

Background The development and evaluation of complex interventions in healthcare has obtained increased awareness. The Medical Research Council’s (MRC) framework for the development and evaluation of complex interventions and its update offers guidance for researchers covering the phases development, feasibility/piloting, and evaluation. Comprehensive reporting of complex interventions enhances transparency and is essential for researchers and policy-makers. Recently, a set of 16 criteria for reporting complex interventions in healthcare (CReDECI) was published. The aim of this study is to evaluate the reporting quality in publications of complex interventions adhering to either the first or the updated MRC framework, and to evaluate the applicability of CReDECI. Methods A systematic PubMed search was conducted. Two reviewers independently checked titles and abstracts for inclusion. Trials on complex interventions adhering to the MRC framework and including an evaluation study in English and German were included. For all included trials and for all publications which reported on phases prior to the evaluation study, related publications were identified via forward citation tracking. The quality of reporting was assessed independently by two reviewers using CReDECI. Inter-rater agreement and time needed to complete the assessment were determined. Results Twenty-six publications on eight trials were included. The number of publications per trial ranged from 1 to 6 (mean 3.25). The trials demonstrate a good reporting quality for the criteria referring to the development and feasibility/piloting. For the criteria addressing the introduction of the intervention and the evaluation, quality of reporting varied widely. Two trials fulfilled 7 and 8 items respectively, five trials fulfilled one to five items and one trial offered no information on any item. The mean number of items with differing ratings per trial was two. The time needed to rate a trial ranged from 30 to 90 minutes, depending on the number of publications. Conclusions Adherence to the MRC framework seems to have a positive impact on the reporting quality on the development and piloting of complex interventions. Reporting on the evaluation could be improved. CReDECI is a practical instrument to check the reporting quality of complex interventions and could be used alongside design-specific reporting guidelines. PMID:24138207

2013-01-01

202

Network meta-analysis of the outcome 'participant complete clearance' in nonimmunosuppressed participants of eight interventions for actinic keratosis: a follow-up on a Cochrane review.  

PubMed

The conclusions of pairwise meta-analyses of interventions for actinic keratosis (AK) are limited due to the lack of direct comparison between some interventions. Consequently, we performed a network meta-analysis for eight treatments [5-aminolaevulinic acid (ALA)-photodynamic therapy (PDT), cryotherapy, diclofenac 3% in 2·5% hyaluronic acid (DCF/HA), 5-fluorouracil (5-FU) 0·5% or 5·0%, imiquimod (IMI) 5%, ingenol mebutate (IMB) 0·015-0·05%, methyl aminolaevulinate (MAL)-PDT and placebo/vehicle (including placebo-PDT)] to determine their relative efficacies. As part of a prior Cochrane systematic review, different databases and grey literature were searched for randomized controlled trials up to April 2012. The inclusion criteria were parallel-group studies with nonimmunosuppressed participants: (i) reporting 'participant complete clearance' and (ii) comparing at least two of the interventions. Thirty-two publications met the criteria and they included the following number of individual or pooled studies (n) and total number of participants (N) for the different interventions: 5-FU 0·5% (n = 4, N = 169), 5-FU 5·0% (n = 2, N = 44), ALA-PDT (n = 6, N = 739), cryotherapy (n = 2, N = 174), DCF/HA (n = 5, N = 299), IMI (n = 14, N = 1411), IMB (n = 3, N = 560), MAL-PDT (n = 7, N = 557) and placebo (n = 32, N = 2520). Network analyses using a random-effects Bayesian model were carried out with the software ADDIS v1.16.1. The interventions were ranked as follows based on calculated probabilities and odd ratios: 5-FU > ALA-PDT ? IMI ? IMB ? MAL-PDT > cryotherapy > DCF/HA > placebo. This efficacy ranking was obtained based on the current available data on 'participant complete clearance' from randomized controlled trials and the analysis model used. However, several other factors should also be considered when prescribing a treatment for AK. PMID:23550994

Gupta, A K; Paquet, M

2013-08-01

203

Ambiguity of Human Gene Symbols in LocusLink and MEDLINE: Creating an Inventory and a Disambiguation Test Collection  

PubMed Central

Genes are discovered almost on a daily basis and new names have to be found. Although there are guidelines for gene nomenclature, the naming process is highly creative. Human genes are often named with a gene symbol and a longer, more descriptive term; the short form is very often an abbreviation of the long form. Abbreviations in biomedical language are highly ambiguous, i.e., one gene symbol often refers to more than one gene. Using an existing abbreviation expansion algorithm, we explore MEDLINE for the use of human gene symbols derived from LocusLink. It turns out that just over 40% of these symbols occur in MEDLINE, however, many of these occurrences are not related to genes. Along the process of making an inventory, a disambiguation test collection is constructed automatically. PMID:14728264

Weeber, Marc; Schijvenaars, Bob J. A.; van Mulligen, Erik M.; Mons, Barend; Jelier, Rob; van der Eijk, Christiaan; Kors, Jan A.

2003-01-01

204

Efficacy of black cohosh (Cimicifuga racemosa) medicines for treatment of menopausal symptoms - comments on major statements of the Cochrane Collaboration report 2012 "black cohosh (Cimicifuga spp.) for menopausal symptoms (review)".  

PubMed

Menopausal symptoms management with high-quality plant extracts from Actaea (Cimicifuga. racemosa rootstock is well-established. Efficacy and safety are supported by research and clinical trials since several decades and backed up by official monographs. However, the recent published Cochrane review on black cohosh neglects major evidence for beneficial effects. The authors' negative conclusions are questionable and call for reply and clarification. Our careful reconsideration of all appropriate placebo-controlled clinical studies reveals a standardized mean difference of 0.385 in favor of black cohosh (p?

Beer, André-M; Osmers, Rüdiger; Schnitker, Jörg; Bai, Wenpei; Mueck, Alfred O; Meden, Harald

2013-12-01

205

MEDLINE and PsycLIT on CD-ROM: a survey of users in an academic medical library.  

PubMed

A survey of users of PsycLIT and MEDLINE on CD-ROM was performed at an academic medical library. The questionnaire was designed to gather information about the user population, satisfaction of the users, the assistance needed to use the systems, and the type of searches being performed. The majority of users were graduate students in the schools of medicine, nursing, and pharmacy. In general, users were satisfied with the performance of the systems. Assistance from a librarian, printed documentation, or another patron was required by 85% of users, and they were generally satisfied with this assistance. Most searches were performed to obtain information on a subject. The results were remarkably similar for both databases. PMID:10106678

King, N S; Goldstein, S E; Williams, L A

1990-01-01

206

Development of a heart failure filter for Medline: an objective approach using evidence-based clinical practice guidelines as an alternative to hand searching  

Microsoft Academic Search

BACKGROUND: Heart failure is a highly debilitating syndrome with a poor prognosis primarily affecting the elderly. Clinicians wanting timely access to heart failure evidence to provide optimal patient care can face many challenges in locating this evidence. This study developed and validated a search filter of high clinical utility for the retrieval of heart failure articles in OvidSP Medline. METHODS:

Raechel A Damarell; Jennifer Tieman; Ruth M Sladek; Patricia M Davidson

2011-01-01

207

A Meta-analysis of the effects of Exercise Training on Left Ventricular Remodeling Following Myocardial Infarction: Start early and go longer for greatest exercise benefits on remodeling  

Microsoft Academic Search

Background  The effects of variations in exercise training on Left ventricular (LV) remodeling in patients shortly after Myocardial Infarction\\u000a (MI) are important but poorly understood.\\u000a \\u000a \\u000a \\u000a \\u000a Methods  Systematic review incorporating meta-analysis using meta-regression. Studies were identified via systematic searches of: OVID\\u000a MEDLINE (1950 to 2009), Cochrane Central Register of Controlled Trials (1991 to 2009), AMED (1985 to 2009), EMBASE (1988 to\\u000a 2009), PUBMED

Mark Haykowsky; Jessica Scott; Ben Esch; Don Schopflocher; Jonathan Myers; Ian Paterson; Darren Warburton; Lee Jones; Alexander M Clark

2011-01-01

208

Comparing a Rule Based vs. Statistical System for Automatic Categorization of MEDLINE® Documents According to Biomedical Specialty  

PubMed Central

Automatic document categorization is an important research problem in Information Science and Natural Language Processing. Many applications, including Word Sense Disambiguation and Information Retrieval in large collections, can benefit from such categorization. This paper focuses on automatic categorization of documents from the biomedical literature into broad discipline-based categories. Two different systems are described and contrasted: CISMeF, which uses rules based on human indexing of the documents by the Medical Subject Headings® (MeSH®) controlled vocabulary in order to assign metaterms (MTs), and Journal Descriptor Indexing (JDI) based on human categorization of about 4,000 journals and statistical associations between journal descriptors (JDs) and textwords in the documents. We evaluate and compare the performance of these systems against a gold standard of humanly assigned categories for one hundred MEDLINE documents, using six measures selected from trec_eval. The results show that for five of the measures, performance is comparable, and for one measure, JDI is superior. We conclude that these results favor JDI, given the significantly greater intellectual overhead involved in human indexing and maintaining a rule base for mapping MeSH terms to MTs. We also note a JDI method that associates JDs with MeSH indexing rather than textwords, and it may be worthwhile to investigate whether this JDI method (statistical) and CISMeF (rule based) might be combined and then evaluated showing they are complementary to one another. PMID:19956557

Humphrey, Susanne M.; Neveol, Aurelie; Gobeil, Julien; Ruch, Patrick; Darmoni, Stefan J.; Browne, Allen

2009-01-01

209

Comparing a Rule Based vs. Statistical System for Automatic Categorization of MEDLINE Documents According to Biomedical Specialty.  

PubMed

Automatic document categorization is an important research problem in Information Science and Natural Language Processing. Many applications, including Word Sense Disambiguation and Information Retrieval in large collections, can benefit from such categorization. This paper focuses on automatic categorization of documents from the biomedical literature into broad discipline-based categories. Two different systems are described and contrasted: CISMeF, which uses rules based on human indexing of the documents by the Medical Subject Headings(®) (MeSH(®)) controlled vocabulary in order to assign metaterms (MTs), and Journal Descriptor Indexing (JDI) based on human categorization of about 4,000 journals and statistical associations between journal descriptors (JDs) and textwords in the documents. We evaluate and compare the performance of these systems against a gold standard of humanly assigned categories for one hundred MEDLINE documents, using six measures selected from trec_eval. The results show that for five of the measures, performance is comparable, and for one measure, JDI is superior. We conclude that these results favor JDI, given the significantly greater intellectual overhead involved in human indexing and maintaining a rule base for mapping MeSH terms to MTs. We also note a JDI method that associates JDs with MeSH indexing rather than textwords, and it may be worthwhile to investigate whether this JDI method (statistical) and CISMeF (rule based) might be combined and then evaluated showing they are complementary to one another. PMID:19956557

Humphrey, Susanne M; Névéol, Aurélie; Gobeil, Julien; Ruch, Patrick; Darmoni, Stéfan J; Browne, Allen

2009-12-01

210

Self-Service Computerized Bibliographic Retrieval: A Comparison of Colleague and PaperChase, Programs That Search the MEDLINE Database  

PubMed Central

Colleague and PaperChase are the two most widely used computer systems designed for clinicians and scientists who wish to search the National Library of Medicine's MEDLINE data base of biomedical references. The present study compares the performance of these two systems. Two matched groups of second-year medical students each received three hours of instruction, one group in Colleague, the other in PaperChase. Each student then attempted 10 test searches. The next day the groups were reversed, and each student attempted five additional searches. During the 3.5 hours allocated for searching, users of Colleague attempted 64 test searches and retrieved 326 target references; users of PaperChase attempted 78 searches and retrieved 496. Users of Colleague took a mean of 2.2 minutes and spent a mean of $1.20 to find each target reference; users of PaperChase took 1.6 minutes and spent $0.92. We conclude that after limited training, medical students find more references faster and at lower cost with PaperChase than with Colleague.

Porter, Douglas; Wigton, Robert S.; Reidelbach, Marie A.; Bleich, Howard L.; Slack, Warner V.

1988-01-01

211

About MedlinePlus  

MedlinePLUS

... Director Dr. Donald A.B. Lindberg, Director, National Library of Medicine View Dr. Lindberg's welcome (Quicktime video ... good health information from the world's largest medical library, the National Library of Medicine. Health professionals and ...

212

MedlinePlus: Drugs, Herbs and Supplements: MedlinePlus  

MedlinePLUS

... Topics Drugs & Supplements Videos & Cool Tools ESPAÑOL Drugs, Supplements, and Herbal Information Drugs Learn about your prescription ... included in drug packages, see DailyMed . Herbs and Supplements Browse dietary supplements and herbal remedies to learn ...

213

Medical Encyclopedia: MedlinePlus  

MedlinePLUS

... Topics Drugs & Supplements Videos & Cool Tools ESPAÑOL Medical Encyclopedia To use the sharing features on this page, ... enable JavaScript. The A.D.A.M. Medical Encyclopedia includes over 4,000 articles about diseases, tests, ...

214

Surgery Videos: MedlinePlus  

MedlinePLUS Videos and Cool Tools

... TEE) (Shawnee Mission Medical Center, Merriam, KS, 2/17/2009) Arrhythmia Electrophysiological Study and Catheter Ablation with ... TEE) (Shawnee Mission Medical Center, Merriam, KS, 2/17/2009) Heart Failure Surgical Ventricular Reconstruction (Montefiore Medical ...

215

Articles about MedlinePlus  

MedlinePLUS

... pubmedcentral.nih.gov/articlerender.fcgi?artid=1324769 Mayer S, Smith KH, Rios G. Consumer health information services 2. ... purchase. DOI: 10.1197/jamia.M2449 Keselman A, Smith CA, Divita G, Kim H, Browne AC, Leroy ...

216

Health Topics: MedlinePlus  

MedlinePLUS

... Metabolic Problems Poisoning, Toxicology, Environmental Health Pregnancy and Reproduction Substance Abuse Problems Diagnosis and Therapy Complementary and Alternative Therapies Diagnostic Tests Drug Therapy Surgery and Rehabilitation Symptoms Transplantation and ...

217

Anatomy Videos: MedlinePlus  

MedlinePLUS Videos and Cool Tools

... Blood clotting Blood flow Blood pressure Brain components Breast lift Breathing Bunion Cancer of the throat or larynx Cardiac conduction system Cardiomyopathy Cardiovascular system Cataract Cell division Cerebral ... conduction Osteoarthritis Osteoporosis Ovulation Parkinson's ...

218

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH SEARCH RESULT Joseph Zasadzinski || Change Password || View/Change User Information || CiteTrack Personal Alerts || Subscription HELP ||  

E-print Network

|| View/Change User Information || CiteTrack Personal Alerts || Subscription HELP || Sign Out Biophysical in: Biophys. J. Online PubMed PubMed Citation Search Medline for articles by: Zasadzinski, J. Alert

Zasadzinski, Joseph A.

219

An assessment of the efficacy of searching in biomedical databases beyond MEDLINE in identifying studies for a systematic review on ward closures as an infection control intervention to control outbreaks  

PubMed Central

Background The purpose of our study is to determine the value and efficacy of searching biomedical databases beyond MEDLINE for systematic reviews. Methods We analyzed the results from a systematic review conducted by the authors and others on ward closure as an infection control practice. Ovid MEDLINE including In-Process & Other Non-Indexed Citations, Ovid Embase, CINAHL Plus, LILACS, and IndMED were systematically searched for articles of any study type discussing ward closure, as were bibliographies of selected articles and recent infection control conference abstracts. Search results were tracked, recorded, and analyzed using a relative recall method. The sensitivity of searching in each database was calculated. Results Two thousand ninety-five unique citations were identified and screened for inclusion in the systematic review: 2,060 from database searching and 35 from hand searching and other sources. Ninety-seven citations were included in the final review. MEDLINE and Embase searches each retrieved 80 of the 97 articles included, only 4 articles from each database were unique. The CINAHL search retrieved 35 included articles, and 4 were unique. The IndMED and LILACS searches did not retrieve any included articles, although 75 of the included articles were indexed in LILACS. The true value of using regional databases, particularly LILACS, may lie with the ability to search in the language spoken in the region. Eight articles were found only through hand searching. Conclusions Identifying studies for a systematic review where the research is observational is complex. The value each individual study contributes to the review cannot be accurately measured. Consequently, we could not determine the value of results found from searching beyond MEDLINE, Embase, and CINAHL with accuracy. However, hand searching for serendipitous retrieval remains an important aspect due to indexing and keyword challenges inherent in this literature. PMID:25387523

2014-01-01

220

Mining Scientific Data from Pub-Med Database  

Microsoft Academic Search

The continuous, rapidly growing volume of scientific literature and increasing diversification of inter-disciplinary fields of science and their answers to unsolved problems in medical and allied fields of science present a major problem to scientists and librarians. It should be recalled in this aspect that today as many as 4800 scientific journals exist in the internet of which some are

2012-01-01

221

Incidence of neoplasms in the most prevalent autoimmune rheumatic diseases: a systematic review.  

PubMed

This article is a systematic review of the literature about the coexistence of cancer and autoimmune rheumatic diseases, their main associations, cancers and possible risk factors associated, with emphasis on existing population-based studies, besides checking the relation of this occur with the use of the drugs used in the treatment of autoimmune diseases. A search was conducted of scientific articles indexed in the Cochrane / BVS, Pubmed / Medline and Scielo / Lilacs in the period from 2002 to 2012. Also consulted was the IB-ICT (Brazilian digital library of theses and Masters), with descriptors in Portuguese and English for "Systemic sclerosis", "Rheumatoid Arthritis", " Systemic Lupus Erythematosus" and "Sjögren's syndrome", correlating each one with the descriptor AND "neoplasms". The results showed that in the database IBICT a thesis and a dissertation for the descriptor SLE met the inclusion criteria, none met RA one thesis to SS. Lilacs in the database/Scielo found two articles on "Rheumatoid Arthritis" AND "neoplasms". In Pubmed/Medline the inicial search resulted in 118 articles, and 41 were selected. The review noted the relationship between cancer and autoimmune rheumatic diseases, as well as a risk factor for protection, although the pathophysiological mechanisms are not known. PMID:24878860

Machado, Roberta Ismael Lacerda; Braz, Alessandra de Sousa; Freire, Eutilia Andrade Medeiros

2014-01-01

222

Hamstring rehabilitation.  

E-print Network

??Objective: To evaluate the methodological quality of hamstring rehabilitation studies found in the current literature. Data Sources: Pubmed (1950- 2006), MEDLINE, CINAHL (1982- 2007), CINAHL… (more)

Siegel, Lori L.

2007-01-01

223

Cognitive training for early-stage Alzheimer's disease and dementia.  

PubMed

The purpose of this article is to critically review and synthesize the literature on the effects of nonpharmacological cognitive training on dementia symptoms in early-stage Alzheimer's disease (AD) and related dementia. Electronic databases MEDLINE (PubMed), CINAHL, PsycInfo, and the Cochrane Library were searched using the keywords cognition, reality orientation, Alzheimer's disease, psychosocial factors, cognitive therapy, brain plasticity, enriched environments, and memory training. The findings support that cognitive training improves cognition, activities of daily living, and decision making. Interventions are more effective if they are structured and focus on specific known losses related to the AD pathological process and a person's residual ability, or are combined with cognitive-enhancing medications. Nursing implications are also discussed. PMID:19326826

Yu, Fang; Rose, Karen M; Burgener, Sandra C; Cunningham, Cindy; Buettner, Linda L; Beattie, Elizabeth; Bossen, Ann L; Buckwalter, Kathleen C; Fick, Donna M; Fitzsimmons, Suzanne; Kolanowski, Ann; Janet, K; Specht, Pringle; Richeson, Nancy E; Testad, Ingelin; McKenzie, Sharon E

2009-03-01

224

An evidence-based review of fat modifying supplemental weight loss products.  

PubMed

Objective. To review the literature on fat modifying dietary supplements commonly used for weight loss. Methods. Recently published randomized, placebo-controlled trials were identified in PubMed, MEDLINE, International Pharmaceutical Abstracts, Cochrane Database, and Google Scholar using the search terms dietary supplement, herbal, weight loss, obesity, and individual supplement names. Discussion. Data for conjugated linoleic acid (CLA), Garcinia cambogia, chitosan, pyruvate, Irvingia gabonensis, and chia seed for weight loss were identified. CLA, chitosan, pyruvate, and Irvingia gabonensis appeared to be effective in weight loss via fat modifying mechanisms. However, the data on the use of these products is limited. Conclusion. Many obese people use dietary supplements for weight loss. To date, there is little clinical evidence to support their use. More data is necessary to determine the efficacy and safety of these supplements. Healthcare providers should assist patients in weighing the risks and benefits of dietary supplement use for weight loss. PMID:20847896

Egras, Amy M; Hamilton, William R; Lenz, Thomas L; Monaghan, Michael S

2011-01-01

225

Pharmaceutical applications and phytochemical profile of Cinnamomum burmannii.  

PubMed

Extensive studies have been carried out in the last decade to assess the pharmaceutical potential and screen the phytochemical constituents of Cinnamomum burmannii. Databases such as PubMed (MEDLINE), Science Direct (Embase, Biobase, biosis), Scopus, Scifinder, Google Scholar, Google Patent, Cochrane database, and web of science were searched using a defined search strategy. This plant is a member of the genus Cinnamomum and is traditionally used as a spice. Cinnamomum burmannii have been demonstrated to exhibit analgesic, antibacterial, anti-diabetic, anti-fungal, antioxidant, antirheumatic, anti-thrombotic, and anti-tumor activities. The chemical constituents are mostly cinnamyl alcohol, coumarin, cinnamic acid, cinnamaldehyde, anthocynin, and essential oils together with constituents of sugar, protein, crude fats, pectin, and others. This review presents an overview of the current status and knowledge on the traditional usage, the pharmaceutical, biological activities, and phytochemical constituents reported for C. burmannii. PMID:23055638

Al-Dhubiab, Bandar E

2012-07-01

226

Nanotechnology and its Application in Dentistry  

PubMed Central

Nanotechnology influences almost every facet of everyday life from security to medicine. The concept of nanotechnology is that when one goes down to the bottom of things, one can discover unlimited possibilities and potential of the basic particle. In nanotechnology, analysis can be made to the level of manipulating atoms, molecules and chemical bonds between them. The growing interest in the dental applications of nanotechnology is leading to the emergence of a new field called nanodentistry. An electronic database search that included PubMed, MedLine, and Cochrane library was conducted. Key words used in the search are nanotechnology dentistry and applications. Language limitation was set as articles reviewed were only those written and published in English language. We did not search the gray literature. Initially, 52 articles were retrieved from the database, and articles considered were those published from 2008 to 2013. Eight articles that met the selection criteria were eventually selected and reviewed. PMID:25364585

Abiodun-Solanke, IMF; Ajayi, DM; Arigbede, AO

2014-01-01

227

Pharmacological treatments for frontotemporal dementias: a systematic review of randomized controlled trials.  

PubMed

The objective of this review is to summarize the current data on the pharmacological treatments for frontotemporal dementias from randomized controlled trials. A systematic search of 4 major databases, PubMed, Medline, PsychINFO and Cochrane, found a total of 9 randomized controlled, double-blinded clinical trials. Of these, 2 trials used the selective serotonin reuptake inhibitor (SSRI), paroxetine; 1 trial used trazodone; 2 trials used stimulants (methylphenidate and dextroamphetamine); 1 trial used the acetylcholinesterase inhibitor, galantamine; 2 trials used the N-methyl-d-aspartate antagonist, memantine; and 1 trial used the neuropeptide oxytocin. The analysis of the available data indicates that SSRIs, trazodone, and the amphetamines may be effective in reducing some behavioral symptoms, but none of these medications had an impact on cognition. Available data indicate that these medications were well tolerated in all the trials. PMID:24164931

Nardell, Maria; Tampi, Rajesh R

2014-03-01

228

Picture perfect: benefits and risk of fetal 3D ultrasound.  

PubMed

The purpose of this literature review was to survey available information and research related to routine three-dimensional (3D) ultrasound technology in obstetrics, with an emphasis on current medical uses, safety, and availability issues. Several data bases, including Cochrane, WHO, NIH, CINALH, Blackwell Synergy, ERIC, PubMed, and Medline, were used along with information from Internet search engines. Although fetal 3D ultrasound is used in both medical and commercial settings, recent studies focus on its possible uses rather than the more difficult issues of safety and commercial applications. Professional organizations associated with ultrasound technology support limiting ultrasounds in pregnancy to medically necessary events, whereas commercial venues use "direct to consumer" marketing to promote this technology as a way to "see" the baby before it is born. How safe is routine or frequent use of 3D ultrasound? Further research is needed to address these important questions. PMID:17356416

Wiseman, Claudia S; Kiehl, Ermalynn M

2007-01-01

229

An Evidence-Based Review of Fat Modifying Supplemental Weight Loss Products  

PubMed Central

Objective. To review the literature on fat modifying dietary supplements commonly used for weight loss. Methods. Recently published randomized, placebo-controlled trials were identified in PubMed, MEDLINE, International Pharmaceutical Abstracts, Cochrane Database, and Google Scholar using the search terms dietary supplement, herbal, weight loss, obesity, and individual supplement names. Discussion. Data for conjugated linoleic acid (CLA), Garcinia cambogia, chitosan, pyruvate, Irvingia gabonensis, and chia seed for weight loss were identified. CLA, chitosan, pyruvate, and Irvingia gabonensis appeared to be effective in weight loss via fat modifying mechanisms. However, the data on the use of these products is limited. Conclusion. Many obese people use dietary supplements for weight loss. To date, there is little clinical evidence to support their use. More data is necessary to determine the efficacy and safety of these supplements. Healthcare providers should assist patients in weighing the risks and benefits of dietary supplement use for weight loss. PMID:20847896

Egras, Amy M.; Hamilton, William R.; Lenz, Thomas L.; Monaghan, Michael S.

2011-01-01

230

Neuraxial opioid-induced pruritus: An update  

PubMed Central

Pruritus is a troublesome side-effect of neuraxial (epidural and intrathecal) opioids. Sometimes it may be more unpleasant than pain itself. The prevention and treatment still remains a challenge. A variety of medications with different mechanisms of action have been used for the prevention and treatment of opioid-induced pruritus, with mixed results. The aim of this article is to review the current body of literature and summarize the current understanding of the mechanisms and the pharmacological therapies available to manage opioid-induced pruritus. The literature source of this review was obtained via PubMed, Medline and Cochrane Database of Systematic Reviews until 2012. The search results were limited to the randomized controlled trials, systemic reviews and non-systemic reviews. PMID:24106351

Kumar, Kamal; Singh, Sudha Indu

2013-01-01

231

Pharmacokinetic drug-drug interaction and their implication in clinical management  

PubMed Central

Drug-drug interactions (DDIs) are one of the commonest causes of medication error in developed countries, particularly in the elderly due to poly-therapy, with a prevalence of 20-40%. In particular, poly-therapy increases the complexity of therapeutic management and thereby the risk of clinically important DDIs, which can both induce the development of adverse drug reactions or reduce the clinical efficacy. DDIs can be classify into two main groups: pharmacokinetic and pharmacodynamic. In this review, using Medline, PubMed, Embase, Cochrane library and Reference lists we searched articles published until June 30 2012, and we described the mechanism of pharmacokinetic DDIs focusing the interest on their clinical implications. PMID:24516494

Palleria, Caterina; Di Paolo, Antonello; Giofre, Chiara; Caglioti, Chiara; Leuzzi, Giacomo; Siniscalchi, Antonio; De Sarro, Giovambattista; Gallelli, Luca

2013-01-01

232

NeuroinformaticsNeuroinformatics ISSN 15392791 Volume 3 Number 3 2005  

E-print Network

Journals.com Search,Read,and D ow nload Indexed and Abstracted in: Medline/Pubmed/Index Medicus Science Citation Index® Indexed and Abstracted in: Medline/Pubmed/Index Medicus Science Citation Index® Editors Giorgio A. Ascoli and tetanus induced network plasticity. The simulated model was a "leaky integrate-and-fire" (LIF) neural

233

New approach to managing genital warts  

PubMed Central

Abstract Objective To summarize and determine the appropriate use for the new and old management tools for genital warts. Sources of information The following databases were searched: MEDLINE, PubMed, EMBASE, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, ACP Journal Club, and Trip. The bibliographies of retrieved papers were also reviewed. Clinical trials, qualitative review articles, consensus reports, and clinical practice guidelines were retrieved. Main message Symptomatic warts are prevalent in at least 1% of the population between the ages of 15 and 49, with estimates of up to 50% of the population being infected with human papillomavirus at some point in their lifetime. Imiquimod and podophyllotoxin are 2 new treatments for external genital warts that are less painful and can be applied by patients at home. In addition, the quadrivalent human papillomavirus vaccine has been shown to be efficacious in preventing genital warts and cervical cancer. There is still a role for the older treatment methods in certain situations, such as intravaginal, urethral, anal, or recalcitrant warts; or for pregnant patients. Conclusion The new treatments of external genital warts can reduce the pain of treatment and the number of office visits. Other treatment methods are still useful in certain situations. PMID:23851535

Lopaschuk, Catharine C.

2013-01-01

234

The Physiological and Biochemical Outcomes Associated with a Reflexology Treatment: A Systematic Review  

PubMed Central

Background. Reflexology is one of the top forms of complementary and alternative medicine in the UK and is used for healthcare by a diverse range of people. However, it is offered by few healthcare providers as little scientific evidence is available explaining how it works or any health benefits it may confer. The aim of this review was to assess the current evidence available from reflexology randomised controlled trials (RCTs) that have investigated changes in physiological or biochemical outcomes. Methods. Guidelines from the Cochrane Handbook of Systematic Reviews of Interventions were followed: the following databases were searched from inception to December 2013: AMED, CAM Quest, CINAHL Plus, Cochrane Central Register of Controlled Trials, Embase, Medline Ovid, Proquest, and Pubmed. Risk of bias was assessed independently by two members of the review team and overall strength of the evidence was assessed using the Grading of Recommendations, Assessment, Development, and Evaluation guidelines. Results. Seventeen eligible RCTs met all inclusion criteria. A total of 34 objective outcome measures were analysed. Although twelve studies showed significant changes within the reflexology group, only three studies investigating blood pressure, cardiac index, and salivary amylase resulted in significant between group changes in favour of reflexology. The overall quality of the studies was low. PMID:24883067

McCullough, J. E. M.; Liddle, S. D.; Sinclair, M.; Close, C.; Hughes, C. M.

2014-01-01

235

Prospective Head and Neck Cancer Research: A Four-Decade Bibliometric Perspective  

PubMed Central

Background. It is unknown whether changes in study sponsorship have affected the proportion of prospective research on surgery, radiotherapy, and pharmacotherapy for head and neck squamous cell carcinoma (HNSCC) being published over time. Patients and Methods. We examined prospective studies from PubMed, Ovid MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials from 1980, 1985, 1990, 1995, 2000, 2005, and 2010. Chi-squared tests were used to identify significant associations between sponsorship and authorship, treatments within study protocols, and presentation of results, whereas time-based trends were analyzed using the Cochran-Armitage test. Results. Among 309 articles, industry (70, 22.7%) and the U.S. government (65, 21%) were the most common sponsors. There was a significant increase in the proportion of industry-sponsored research (p for trend = .013) and a decline in U.S. government-sponsored research (p for trend = .001) over time. The inclusion of surgery in treatment protocols declined over the past four decades (p for trend = .003). Protocols incorporating pharmacotherapy were more likely to have industry support than those without pharmacotherapy (p = .001), whereas protocols with radiotherapy (p = .003) or surgery (p = .002) were less likely to have industry support. Conclusion. Industry is the predominant sponsor of prospective HNSCC research, with an emphasis on pharmacotherapy. PMID:23635559

Houlton, Jeffrey J.; Moloci, Nicholas M.; MacEachern, Mark P.; Bradford, Carol R.; Prince, Mark E.; Jagsi, Reshma

2013-01-01

236

The effectiveness of opioid substitution treatments for patients with opioid dependence: a systematic review and multiple treatment comparison protocol  

PubMed Central

Background Opioids are psychoactive analgesic drugs prescribed for pain relief and palliative care. Due to their addictive potential, effort and vigilance in controlling prescriptions is needed to avoid misuse and dependence. Despite the effort, the prevalence of opioid use disorder continues to rise. Opioid substitution therapies are commonly used to treat opioid dependence; however, there is minimal consensus as to which therapy is most effective. Available treatments include methadone, heroin, buprenorphine, as well as naltrexone. This systematic review aims to assess and compare the effect of all available opioid substitution therapies on the treatment of opioid dependence. Methods/Design The authors will search Medline, EMBASE, PubMed, PsycINFO, Web of Science, Cochrane Library, Cochrane Clinical Trials Registry, World Health Organization International Clinical Trials Registry Platform Search Portal, and the National Institutes for Health Clinical Trials Registry. The title, abstract, and full-text screening will be completed in duplicate. When appropriate, multiple treatment comparison Bayesian meta-analytic methods will be performed to deduce summary statistics estimating the effectiveness of all opioid substitution therapies in terms of retention and response to treatment (as measured through continued opioid abuse). Discussion Using evidence gained from this systematic review, we anticipate disseminating an objective review of the current available literature on the effectiveness of all opioid substitution therapies for the treatment of opioid use disorder. The results of this systematic review are imperative to the further enhancement of clinical practice in addiction medicine. Systematic review registration PROSPERO CRD42013006507. PMID:25239213

2014-01-01

237

A systematic review of surgical ablation versus catheter ablation for atrial fibrillation  

PubMed Central

Background Atrial fibrillation (AF) is an increasingly prevalent condition in the ageing population, with significantly associated morbidity and mortality. Surgical and catheter ablative strategies both aim to reduce mortality and morbidity through freedom from AF. This review consolidates all currently available comparative data to evaluate these two interventions. Methods A systematic search was conducted across MEDLINE, PubMed, Embase, Cochrane Central Register of Controlled Trials and the Cochrane Database of Systematic Reviews from January 2000 until August 2013. All studies were critically appraised and only those directly comparing surgical and catheter ablation were included. Results Seven studies were deemed suitable for analysis according to the inclusion criteria. Freedom from AF was significantly higher in the surgical ablation group versus the catheter ablation group at 6-month, 12-month and study endpoint follow-up periods. Subgroup analysis demonstrated similar trends, with higher freedom from AF in the surgical ablation group for paroxysmal AF patients. The incidence of pacemaker implantation was higher, while no difference in stroke or cardiac tamponade was demonstrated for the surgical versus catheter ablation groups. Conclusions Current evidence suggests that epicardial ablative strategies are associated with higher freedom from AF, higher pacemaker implantation rates and comparable neurological complications and cardiac tamponade incidence to catheter ablative treatment. Other complications and risks were poorly reported, which warrants further randomized controlled trials (RCTs) of adequate power and follow-up duration. PMID:24516794

Kearney, Katherine; Stephenson, Rowan; Phan, Kevin; Chan, Wei Yen; Huang, Min Yin

2014-01-01

238

Analgesic efficacy and safety of single-dose tramadol and non-steroidal anti-inflammatory drugs in operations on the third molars: a systematic review and meta-analysis.  

PubMed

The aim of this systematic review and meta-analysis was to evaluate published randomised, double-blind, clinical trials to compare the analgesic efficacy and safety of tramadol with that of non-steroidal anti-inflammatory drugs (NSAID) in operations on the third molars. We identified eligible reports from searches of PubMed, MedLine, the Cochrane Library, Oxford Pain Relief database, Imbiomed, and Google Scholar. The full text of studies that met our minimum requirements were evaluated using inclusion and exclusion criteria with the Oxford Quality Scale. Those with a Score ? 3 in this scale were included and their data were extracted and analysed. Absolute increase in risk, the number needed to harm, odds ratio and 95% CI were calculated using Risk Reduction Calculator software. Each meta-analysis was made with the help of the Mantel-Haenszel random effects model, estimates of risk (odds ratio (OR)) and 95% CI were calculated using the Review Manager 5.2. from the Cochrane Library. A significant risk was assumed when the lower limit of the 95%CI was greater than 1. Probabilities of less than 0.05 were accepted as significant. The results showed that tramadol had less analgesic efficacy and an increased risk of adverse effects compared with NSAID. In conclusion, a single dose of tramadol was not as effective or as safe as NSAID for the relief of pain after operations on the third molars. PMID:24930627

Isiordia-Espinoza, Mario Alberto; de Jesús Pozos-Guillén, Amaury; Aragon-Martinez, Othoniel Hugo

2014-11-01

239

Interventions to support children's engagement in health-related decisions: a systematic review  

PubMed Central

Background Children often need support in health decision-making. The objective of this study was to review characteristics and effectiveness of interventions that support health decision-making of children. Methods A systematic review. Electronic databases (PubMed, the Cochrane Library, Web of Science, Scopus, ProQuest Dissertations and Theses, CINAHL, PsycINFO, MEDLINE, and EMBASE) were searched from inception until March 2012. Two independent reviewers screened eligibility: a) intervention studies; b) involved supporting children (?18 years) considering health-related decision(s); and c) measured decision quality or decision-making process outcomes. Data extraction and quality appraisal were conducted by one author and verified by another using a standardized data extraction form. Quality appraisal was based on the Cochrane Risk of Bias tool. Results Of 4313 citations, 5 studies were eligible. Interventions focused on supporting decisions about risk behaviors (n?=?3), psycho-educational services (n?=?1), and end of life (n?=?1). Two of 5 studies had statistically significant findings: i) compared to attention placebo, decision coaching alone increased values congruence between child and parent, and child satisfaction with decision-making process (lower risk of bias); ii) compared to no intervention, a workshop with weekly assignments increased overall decision-making quality (higher risk of bias). Conclusions Few studies have focused on interventions to support children’s participation in decisions about their health. More research is needed to determine effective methods for supporting children’s health decision-making. PMID:24758566

2014-01-01

240

Is fibrin sealant effective and safe in total knee arthroplasty? A meta-analysis of randomized trials.  

PubMed

The objective of this study was to evaluate the efficacy and safety of fibrin sealant in patients following total knee arthroplasty (TKA). A comprehensive literature search of the electronic databases PubMed, MEDLINE, Web of Science, and Cochrane Library for published randomized controlled trials (RCTs) was undertaken. The evidence base was critically appraised using a tool from the Cochrane Bone, Joint and Muscle Trauma Group. Eight RCTs involving 641 patients were included. The use of fibrin sealant significantly reduced postoperative drainage (weighted mean difference (WMD) -346, 95% confidence interval (CI) -496.29 to -197.54, P?

Wang, Hongsheng; Shan, Liancheng; Zeng, Hui; Sun, Mengxiong; Hua, Yingqi; Cai, Zhengdong

2014-01-01

241

Prevention of and Therapies for Nipple Pain: A Systematic Review  

Microsoft Academic Search

Objective: To review the literature on nipple pain and to delineate effective strategies for the pre- vention and treatment of nipple pain in breastfeeding mothers. Data Sources: Computerized searches on MED- LINE, Pre-MEDLINE, CINAHL, and the Cochrane Library.

Kristine Morland-Schultz; Pamela D. Hill

242

Mapping Systematic Reviews on Atopic Eczema—An Essential Resource for Dermatology Professionals and Researchers  

PubMed Central

Background Many research studies have been published on atopic eczema and these are often summarised in systematic reviews (SRs). Identifying SRs can be time-consuming for health professionals, and researchers. In order to facilitate the identification of important research, we have compiled an on-line resource that includes all relevant eczema reviews published since 2000. Methods SRs were searched for in MEDLINE (Ovid), EMBASE (Ovid), PubMed, the Cochrane Database of Systematic Reviews, DARE and NHS Evidence. Selected SRs were assessed against the pre-defined eligibility criteria and relevant articles were grouped by treatment category for the included interventions. All identified systematic reviews are included in the Global Resource of EczemA Trials (GREAT) database (www.greatdatabase.org.uk) and key clinical messages are summarised here. Results A total of 128 SRs reviews were identified, including three clinical guidelines. Of these, 46 (36%) were found in the Cochrane Library. No single database contained all of the SRs found. The number of SRs published per year has increased substantially over the last thirteen years, and reviews were published in a variety of clinical journals. Of the 128 SRs, 1 (1%) was on mechanism, 37 (29%) were on epidemiology, 40 (31%) were on eczema prevention, 29 (23%) were on topical treatments, 31 (24%) were on systemic treatments, and 24 (19%) were on other treatments. All SRs included searches of MEDLINE in their search methods. One hundred six SRs (83%) searched more than one electronic database. There were no language restrictions reported in the search methods of 52 of the SRs (41%). Conclusions This mapping of atopic eczema reviews is a valuable resource. It will help healthcare practitioners, guideline writers, information specialists, and researchers to quickly identify relevant up-to-date evidence in the field for improving patient care. PMID:23505516

Futamura, Masaki; Thomas, Kim S.; Grindlay, Douglas J. C.; Doney, Elizabeth J.; Torley, Donna; Williams, Hywel C.

2013-01-01

243

Tacrolimus versus ciclosporin as primary immunosuppression for kidney transplant recipients: meta-analysis and meta-regression of randomised trial data  

Microsoft Academic Search

Objective To compare the positive and negative effects of tacrolimus and ciclosporin as initial treatment for renal transplant recipients. Design Systematic review. Data sources and study selection Reports of comparative randomised trials of tacrolimus and ciclosporin identified by searches of Medline, Embase, the Cochrane Register of Controlled Trials, the Cochrane Renal Group Specialist Register, and conference proceedings. Data extraction and

Angela C Webster; Rebecca C Woodroffe; Rod S Taylor; Jeremy R Chapman; Jonathan C Craig

2005-01-01

244

Fluoridated milk may be beneficial to schoolchildren by helping prevent caries  

Microsoft Academic Search

Data sources Data sources were the Cochrane Oral Health Group Trials Register, Cochrane Central Register of Controlled Trials, Medline and OLDMedline, Embase, LILACS (Latin American and Caribbean Health Sciences Literature), BBO (Brazilian Bibliography of Dentistry), SIGLE (System for Information on Grey Literature in Europe) and Digital Dissertations. Bibliographies of relevant articles were searched and attempts were made to identify unpublished

Svante Twetman

2005-01-01

245

A systematic review of techniques and interventions for improving adherence to inclusion and exclusion criteria during enrolment into randomised controlled trials  

Microsoft Academic Search

BACKGROUND: Enrolment of patients into a randomised controlled trial (RCT) in violation of key inclusion or exclusion criteria, may lead to excess avoidable harm. The purpose of this paper was to systematically identify and review techniques and interventions proven to prevent or avoid inappropriate enrolment of patients into RCTs. METHODS: EMBASE, MEDLINE, Cochrane Database of Systematic Reviews, Cochrane Methodology Register,

Fiona Simpson; Elizabeth A Sweetman; Gordon S Doig

2010-01-01

246

Systematic reviews of complementary therapies - an annotated bibliography. Part 1: Acupuncture  

Microsoft Academic Search

BACKGROUND: Complementary therapies are widespread but controversial. We aim to provide a comprehensive collection and a summary of systematic reviews of clinical trials in three major complementary therapies (acupuncture, herbal medicine, homeopathy). This article is dealing with acupuncture. Potentially relevant reviews were searched through the register of the Cochrane Complementary Medicine Field, the Cochrane Library, Medline, and bibliographies of articles

Klaus Linde; Andrew Vickers; Maria Hondras; Gerben ter Riet; Johannes Thormählen; Brian Berman; Dieter Melchart

2001-01-01

247

Which filling material is best in the primary dentition?  

Microsoft Academic Search

Data SourcesThe Cochrane Oral Health Group's specialised trial register (Cochrane Central Register of Controlled Trials) was searched along with Medline, Embase and the System for Information on Grey Literature in Europe, along with proceedings from conferences on early childhood caries, restorative materials for paediatric dentistry, and material sciences conferences for dental materials used for children's dentistry. There were no language

Sergio Uribe

2010-01-01

248

Injury Prevention and Future Research  

Microsoft Academic Search

Objectives: To critically examine and summarize the literature identifying risk factors and prevention strategies for injury in child and adolescent sport. Data Sources: Seven electronic databases were searched including: Medline, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Psychinfo, Cochrane Database for Systematic and Complete Reviews, Cochrane Controlled Trials Registry, HealthSTAR and SPORTDiscus. Medical subject headings and text words

C. Emer

2005-01-01

249

Staff training improved oral hygiene in patients following stroke  

Microsoft Academic Search

Data sourcesReports were identified using the Cochrane Stroke Group and Oral Health Group trials registers, the Cochrane CENTRAL trial register, Cochrane Library, Medline, Cinahl, Research Findings Electronic Register, National Research Register, ISI Science and Technology Proceedings, Dissertation Abstracts and Conference Papers Index, and the reference lists from relevant papers. Authors and researchers in the field were also contacted.Study selectionRandomised controlled

Maura Edwards

2008-01-01

250

Healthline | NIH MedlinePlus the Magazine  

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251

Oil Spills - Multiple Languages: MedlinePlus  

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252

Health Information in Thai (???????): MedlinePlus  

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... Disease Control and Prevention B Bacterial Infections Pneumococcal Polysaccharide Vaccine (PPV23) - English ??????? (Thai) PDF Immunization Action ... Coalition; Centers for Disease Control and Prevention Pneumococcal Polysaccharide Vaccine (PPV23) - English ??????? (Thai) PDF Immunization Action ...

253

NLM Director's Comments Podcasts: MedlinePlus  

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254

MedlinePlus.gov (@medlineplus) | Twitter  

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255

Health Information in Korean (???): MedlinePlus  

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256

Hemorrhoids - Multiple Languages: MedlinePlus  

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Oncofertility | NIH MedlinePlus the Magazine  

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259

Earthquakes - Multiple Languages: MedlinePlus  

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260

Healthlines | NIH MedlinePlus the Magazine  

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Chemical Emergencies - Multiple Languages: MedlinePlus  

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262

Cancer - Multiple Languages: MedlinePlus  

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263

Angioplasty - Multiple Languages: MedlinePlus  

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264

Angina - Multiple Languages: MedlinePlus  

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265

Vaginal Diseases - Multiple Languages: MedlinePlus  

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266

Breast Diseases - Multiple Languages: MedlinePlus  

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267

Child Safety - Multiple Languages: MedlinePlus  

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268

Cancer Chemotherapy - Multiple Languages: MedlinePlus  

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269

Childhood Immunization - Multiple Languages: MedlinePlus  

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270

Breastfeeding - Multiple Languages: MedlinePlus  

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271

Breathing Problems - Multiple Languages: MedlinePlus  

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272

Nuclear Scans - Multiple Languages: MedlinePlus  

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273

Childbirth - Multiple Languages: MedlinePlus  

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274

Brain Diseases - Multiple Languages: MedlinePlus  

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275

Gallbladder Diseases - Multiple Languages: MedlinePlus  

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276

Rehabilitation - Multiple Languages: MedlinePlus  

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277

Bone Diseases - Multiple Languages: MedlinePlus  

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278

Allergy - Multiple Languages: MedlinePlus  

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279

Asthma - Multiple Languages: MedlinePlus  

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280

Anemia - Multiple Languages: MedlinePlus  

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281

Breast Cancer - Multiple Languages: MedlinePlus  

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282

Vascular Diseases - Multiple Languages: MedlinePlus  

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283

Radiation Therapy - Multiple Languages: MedlinePlus  

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284

Cervical Cancer - Multiple Languages: MedlinePlus  

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285

Hypoglycemia - Multiple Languages: MedlinePlus  

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286

Back Pain - Multiple Languages: MedlinePlus  

MedlinePLUS

... ???????) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Japanese (???) Korean (???) Russian (???????) Somali (af ... Musculoskeletal and Skin Diseases Return to top French (français) Exercises for Your Back Exercices pour votre dos - ...

287

Kidney Diseases - Multiple Languages: MedlinePlus  

MedlinePLUS

... Languages Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian ( ... Chinese - Traditional) Bilingual PDF Health Information Translations French (français) 24-Hour Urine Test Test d'urine de ...

288

Blood Thinners - Multiple Languages: MedlinePlus  

MedlinePLUS

... Arabic (???????) Bosnian (Bosanski) Chinese - Simplified (????) French (français) Hindi (??????) Japanese (???) Russian (???????) Somali ( ... PDF Health Information Translations Return to top French (français) Coumadin (Warfarin) Coumadine (Warfarine) - français (French) Bilingual PDF ...

289

Laboratory Tests - Multiple Languages: MedlinePlus  

MedlinePLUS

... ???????) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Khmer (Khmer) Korean ( ... Community Health Resource Center Return to top French (français) 24-Hour Urine Test Test d'urine de ...

290

Arthritis - Multiple Languages: MedlinePlus  

MedlinePLUS

... Multiple Languages Arabic (???????) Chinese - Simplified (????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian ( ... Chinese - Simplified) Bilingual PDF Health Information Translations French (français) Arthritis Arthrite - français (French) Bilingual PDF Health Information ...

291

Appendicitis - Multiple Languages: MedlinePlus  

MedlinePLUS

... ???????) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) Portuguese ( ... PDF Health Information Translations Return to top French (français) Appendectomy Appendicectomie - français (French) Bilingual PDF Health Information ...

292

Radiation Emergencies - Multiple Languages: MedlinePlus  

MedlinePLUS

... ???????) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian ( ... PDF Health Information Translations Return to top French (français) Decontamination Décontamination - français (French) Bilingual PDF Health Information ...

293

Ultrasound - Multiple Languages: MedlinePlus  

MedlinePLUS

... ???????) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian ( ... PDF Health Information Translations Return to top French (français) Echocardiogram Échocardiogramme - français (French) Bilingual PDF Health Information ...

294

Arrhythmia - Multiple Languages: MedlinePlus  

MedlinePLUS

... ???????) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian ( ... PDF Health Information Translations Return to top French (français) Electrocardiogram (ECG or EKG) Électrocardiogramme (ECG ou EKG) - ...

295

Back Injuries - Multiple Languages: MedlinePlus  

MedlinePLUS

... Languages Chinese - Simplified (????) Chinese - Traditional (????) French (français) Japanese (???) Korean (???) Russian (???????) Somali (af ... Chinese - Traditional) Bilingual PDF Health Information Translations French (français) Back Health and Safety Santé et sécurité du ...

296

Mobility Aids - Multiple Languages: MedlinePlus  

MedlinePLUS

... ???????) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian ( ... PDF Health Information Translations Return to top French (français) Crutch Walking Marche avec béquilles - français (French) Bilingual ...

297

Colorectal Cancer - Multiple Languages: MedlinePlus  

MedlinePLUS

... Bosanski) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) Portuguese ( ... PDF Health Information Translations Return to top French (français) Cancer of the Colon and Rectum Cancer du ...

298

Sleep Apnea - Multiple Languages: MedlinePlus  

MedlinePLUS

... ???????) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) Portuguese ( ... Community Health Resource Center Return to top French (français) Common Sleep Problem Problèmes de sommeil courants - français ( ...

299

Animal Bites - Multiple Languages: MedlinePlus  

MedlinePLUS

... ???????) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) Portuguese ( ... PDF Health Information Translations Return to top French (français) Animal Bites and Scratches Morsures et griffures d' ...

300

Anal Disorders - Multiple Languages: MedlinePlus  

MedlinePLUS

... JavaScript. Anal Disorders - Multiple Languages Arabic (???????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian ( ... ??? ?????? - ??????? Bilingual Health Information Translations French (français) Barium Enema Lavement baryté - français (French) Bilingual PDF ...

301

Bladder Diseases - Multiple Languages: MedlinePlus  

MedlinePLUS

... ???????) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian ( ... PDF Health Information Translations Return to top French (français) Care of a Foley Catheter Entretien d'une ...

302

Sleep Disorders - Multiple Languages: MedlinePlus  

MedlinePLUS

... ???????) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) Portuguese ( ... PDF Health Information Translations Return to top French (français) Common Sleep Problem Problèmes de sommeil courants - français ( ...

303

Prenatal Testing - Multiple Languages: MedlinePlus  

MedlinePLUS

... ???????) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) Portuguese ( ... PDF Health Information Translations Return to top French (français) AFP (Alpha-Fetoprotein) Test Test AFP (alpha-foetoprotéine) - ...

304

Atrial Fibrillation - Multiple Languages: MedlinePlus  

MedlinePLUS

... Bosanski) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) Portuguese ( ... PDF Health Information Translations Return to top French (français) Atrial Fibrillation Fibrillation auriculaire - français (French) Bilingual PDF ...

305

Neurologic Diseases - Multiple Languages: MedlinePlus  

MedlinePLUS

... Neurologic Diseases - Multiple Languages Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian ( ... Chinese - Traditional) Bilingual PDF Health Information Translations French (français) ... EEG (Électroencéphalogramme) - français (French) Bilingual PDF ...

306

Bone Cancer - Multiple Languages: MedlinePlus  

MedlinePLUS

... ???????) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian ( ... PDF Health Information Translations Return to top French (français) Bone Scan Scintigraphie osseuse - français (French) Bilingual PDF ...

307

Acute Bronchitis - Multiple Languages: MedlinePlus  

MedlinePLUS

... ???????) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian ( ... PDF Health Information Translations Return to top French (français) Bronchitis Bronchite - français (French) Bilingual PDF Health Information ...

308

Thyroid Diseases - Multiple Languages: MedlinePlus  

MedlinePLUS

... ???????) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Japanese (???) Korean (???) Russian (???????) Somali (af ... PDF Health Information Translations Return to top French (français) Thyroid Biopsy Biopsie thyroïdienne - français (French) Bilingual PDF ...

309

Fractures - Multiple Languages: MedlinePlus  

MedlinePLUS

... Multiple Languages Arabic (???????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian ( ... of Arthritis and Musculoskeletal and Skin Diseases French (français) Bone Fractures Fractures osseuses - français (French) Bilingual PDF ...

310

Prenatal Care - Multiple Languages: MedlinePlus  

MedlinePLUS

... Bosanski) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) Portuguese ( ... PDF Health Information Translations Return to top French (français) Fetal Movement Count Compte des mouvements du fœtus - ...

311

Flu - Multiple Languages: MedlinePlus  

MedlinePLUS

... Simplified (????) Chinese - Traditional (????) Farsi (?????) French (français) Haitian Creole (Kreyol) Hindi (??????) Hmong (Hmoob) ... Seattle and King County Return to top French (français) Home Care for Pandemic Flu Soins à domicile ...

312

After Surgery - Multiple Languages: MedlinePlus  

MedlinePLUS

... Bosanski) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) Portuguese ( ... PDF Health Information Translations Return to top French (français) Home Care Instructions After Surgery Instructions relatives aux ...

313

Alzheimer's Disease - Multiple Languages: MedlinePlus  

MedlinePLUS

... Bosanski) Chinese - Simplified (????) Chinese - Traditional (????) French (français) German (Deutsch) Hindi (??????) Italian (italiano) Japanese ( ... Chinese - Traditional) Alzheimer's Association Return to top French (français) Alzheimer's Disease Maladie d'Alzheimer - français (French) Bilingual ...

314

Surgery - Multiple Languages: MedlinePlus  

MedlinePLUS

... Bosanski) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) Portuguese ( ... PDF Health Information Translations Return to top French (français) Biopsy Biopsie - français (French) Bilingual PDF Health Information ...

315

Lung Diseases - Multiple Languages: MedlinePlus  

MedlinePLUS

... ???????) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian ( ... Community Health Resource Center Return to top French (français) Bronchoscopy Bronchoscopie - français (French) Bilingual PDF Health Information ...

316

Pregnancy - Multiple Languages: MedlinePlus  

MedlinePLUS

... Bosanski) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) Portuguese ( ... PDF Health Information Translations Return to top French (français) A Healthy Pregnancy Une grossesse saine - français (French) ...

317

Diabetes - Multiple Languages: MedlinePlus  

MedlinePLUS

... Simplified (????) Chinese - Traditional (????) Chuukese (Trukese) French (français) Gujarathi (???????) Hindi (??????) Hmong (Hmoob) ... Digestive and Kidney Diseases Return to top French (français) Diabetes Diabète - français (French) Bilingual PDF Health Information ...

318

Swallowing Disorders - Multiple Languages: MedlinePlus  

MedlinePLUS

... Languages Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian ( ... Chinese - Traditional) Bilingual PDF Health Information Translations French (français) Barium Swallow Déglutition barytée - français (French) Bilingual PDF ...

319

Colonoscopy - Multiple Languages: MedlinePlus  

MedlinePLUS

... ???????) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian ( ... PDF Health Information Translations Return to top French (français) Colonoscopy with Bowel Prep: Go-Lytely, Colyte, Trilyte, ...

320

Healthlines | NIH MedlinePlus the Magazine  

MedlinePLUS

... image shows the uncontrolled growth of cells in squamous cell carcinoma, the second most common form of skin cancer. If caught early, squamous cell carcinoma is usually not life-threatening. Photo courtesy of ...

321

Brain Cancer - Multiple Languages: MedlinePlus  

MedlinePLUS

... sharing features on this page, please enable JavaScript. Brain Cancer - Multiple Languages French (français) Japanese (???) Korean (???) ... Information Translations Return to top Somali (af Soomaali) Brain Scan Sawiridda ... Cáncer de cerebro Return to top Ukrainian (??????????) Brain ...

322

Healthlines | NIH MedlinePlus the Magazine  

MedlinePLUS

... and activities for elementary and middle school students. Pictures of Nursing These are two of 2,588 ... new exhibition gives a unique look at nursing. Pictures of Nursing is a selection of historic postcards ...

323

Health Information in Ukrainian (??????????): MedlinePlus  

MedlinePLUS

... ?????? - ?????????? (Ukrainian) Bilingual PDF Health Information Translations Concussion Types of Brain Injury ???? ????? ????????? ????? - ... ?????????? (Ukrainian) Bilingual PDF Health Information Translations Prenatal Testing AFP (Alpha-Fetoprotein) Test ?????-?????????????? ?????????? (?????????? ...

324

Health Information in Arabic (???????): MedlinePlus  

MedlinePLUS

... ??? ????? ??????? - ??????? Multimedia Patient Education Institute Nuclear Scans Bone Scan (Arabic) ??????? Bilingual PDF Health ... Arabic) ??????? - ??????? Bilingual PDF Health Information Translations Nuclear or Radiation Emergencies (Arabic) ????? ??????? ??????? ?? ...

325

Health Information in Hindi (??????): MedlinePlus  

MedlinePLUS

... ?????? (Hindi) Bilingual PDF Health Information Translations Power Outages ?????? (Hindi) Bilingual PDF Health Information ... ?????? (Hindi) Bilingual PDF Health Information Translations Nuclear Scans Bone Scan ?????? (Hindi) Bilingual PDF ...

326

Health Information in Japanese (???): MedlinePlus  

MedlinePLUS

... ????????? - ??? (Japanese) Bilingual PDF Health Information Translations Power Outages ?? - ??? (Japanese) Bilingual PDF Health Information ... ??????? - ??? (Japanese) Bilingual PDF Health Information Translations Nuclear Scans Bone Scan ????? - ??? (Japanese) Bilingual PDF ...

327

Heart Diseases - Multiple Languages: MedlinePlus  

MedlinePLUS

... ????? ??????? - ??????? Multimedia Patient Education Institute Electrocardiogram (ECG or EKG) (Arabic) ??????? Bilingual PDF Health Information ... Chinese - Simplified) Bilingual PDF Health Information Translations Electrocardiogram (ECG or EKG) ????ECG?EKG? - ???? (Chinese - Simplified) Bilingual ...

328

Herpes Simplex - Multiple Languages: MedlinePlus  

MedlinePLUS

... sharing features on this page, please enable JavaScript. Herpes Simplex - Multiple Languages Amharic (amarunya) Oromo (Afaan Oromo) Somali (af Soomaali) Spanish (español) Amharic (amarunya) Herpes English amarunya (Amharic) Minnesota Department of Health Oromo ( ...

329

Cataract - Multiple Languages: MedlinePlus  

MedlinePLUS

... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Portuguese (português) Russian (???????) Somali (af Soomaali) ... Bilingual PDF Health Information Translations Return to top Korean (???) Cataract ??? - ??? (Korean) Bilingual PDF Health ...

330

Burns - Multiple Languages: MedlinePlus  

MedlinePLUS

... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian (???????) Somali (af Soomaali) Spanish (español) ... Bilingual PDF Health Information Translations Return to top Korean (???) Burn Care ?? ?? - ??? (Korean) Bilingual ...

331

Circumcision - Multiple Languages: MedlinePlus  

MedlinePLUS

... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian (???????) Somali (af Soomaali) Spanish (español) ... Bilingual PDF Health Information Translations Return to top Korean (???) Male Circumcision ???? - ??? (Korean) Bilingual PDF ...

332

Cholesterol - Multiple Languages: MedlinePlus  

MedlinePLUS

... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Portuguese (português) Russian (???????) Somali (af Soomaali) ... Bilingual PDF Health Information Translations Return to top Korean (???) Cholesterol ????? - ??? (Korean) Bilingual PDF Health ...

333

Concussion - Multiple Languages: MedlinePlus  

MedlinePLUS

... Multiple Languages Arabic (???????) French (français) Japanese (???) Korean (???) Russian (???????) Somali (af Soomaali) Spanish (español) ... Bilingual PDF Health Information Translations Return to top Korean (???) Types of Brain Injury ???? ?? - ??? ( ...

334

COPD - Multiple Languages: MedlinePlus  

MedlinePLUS

... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Portuguese (português) Russian (???????) Somali (af Soomaali) ... Bilingual PDF Health Information Translations Return to top Korean (???) Chronic Obstructive Pulmonary Disease (COPD) ????? ??? - ...

335

Acne - Multiple Languages: MedlinePlus  

MedlinePLUS

... Acne - Multiple Languages Arabic (???????) Chinese - Traditional (????) Korean (???) Spanish (español) Vietnamese (Tiê?ng Viê?t) Arabic (???????) ... Institute of Arthritis and Musculoskeletal and Skin Diseases Korean (???) What Is Acne? English ????? ????? - ??? ( ...

336

Coronavirus Infections - Multiple Languages: MedlinePlus  

MedlinePLUS

... Infections - Multiple Languages Chinese - Traditional (????) Japanese (???) Korean (???) Spanish (español) Vietnamese (Tiê?ng Viê?t) Chinese - Traditional ( ... Japanese) PDF Centers for Disease Control and Prevention Korean (???) Basic Information about SARS English ?????: ??( ...

337

Hepatitis B - Multiple Languages: MedlinePlus  

MedlinePLUS

... ????) Chinese - Traditional (????) Hmong (Hmoob) Khmer (Khmer) Korean (???) Laotian (Lao) Spanish (español) Tagalog (Tagalog) Turkish ( ... Bilingual PDF Harborview Medical Center Return to top Korean (???) Hepatitis B and Moms-to-be English ...

338

Videos and Cool Tools: MedlinePlus  

MedlinePLUS Videos and Cool Tools

... Games All calculators & quizzes Antibiotics Quiz Asthma Quiz Breast Cancer Risk Questionnaire Calcium Calculator Check Up On Your ... Knowledge: Marijuana Vitamin B1 Antibiotics Quiz Asthma Quiz Breast Cancer Risk Questionnaire Calcium Calculator Check Up On Your ...

339

Peptic Ulcer - Multiple Languages: MedlinePlus  

MedlinePLUS

... sharing features on this page, please enable JavaScript. Peptic Ulcer - Multiple Languages Chinese - Simplified (????) Chinese - Traditional (????) ... Simplified (????) Heartburn, Gastrointestinal Reflux Disease (GERD), and Peptic Ulcer English ???, ??????????? - ???? (Chinese - Simplified) PDF Chinese ...

340

Advance Directives - Multiple Languages: MedlinePlus  

MedlinePLUS

... sharing features on this page, please enable JavaScript. Advance Directives - Multiple Languages Arabic (???????) Chinese - Simplified (????) Chinese - ... ???????) Somali (af Soomaali) Spanish (español) Arabic (???????) Advance Directives (Arabic) ????????? ??????? - ??????? Bilingual PDF Health Information ...

341

Healthlines | NIH MedlinePlus the Magazine  

MedlinePLUS

... nlm.nih.gov/digitalprojects.html . Earliest Marker for Autism Found Researchers have found what they say is the earliest sign of developing autism ever observed. A recent study suggests a baby's ...

342

Osteoporosis - Multiple Languages: MedlinePlus  

MedlinePLUS

... enable JavaScript. Osteoporosis - Multiple Languages Arabic (???????) Chinese - Traditional (????) French (français) Russian (???????) Somali (af Soomaali) ... Arabic) ??????? Bilingual PDF Health Information Translations Chinese - Traditional (????) Bone Health and Osteoporosis: A Guide for ...

343

Interactive Health Tutorials: MedlinePlus  

MedlinePLUS Videos and Cool Tools

... Allergies to Dust Mites Alopecia Amyotrophic Lateral Sclerosis (ALS) Angina Anthrax Arrhythmias Arthritis Asthma Atrial Fibrillation Back ... Valve Replacement Hemorrhoid Surgery Hip Replacement Hip Replacement - Physical ... Syndromes (MDS) - Treatment Neurosurgery - What Is It? Open Heart Surgery - What ...

344

MedlinePlus XML Data Sources  

MedlinePLUS

... with that topic. This associated data includes: • basic metadata (health topic title, URL, language, date created, and ... interface, and it relies on the use of medical coding systems in EHRs. When an EHR system ...

345

Phenylketonuria - Multiple Languages: MedlinePlus  

MedlinePLUS

... sharing features on this page, please enable JavaScript. Phenylketonuria - Multiple Languages Arabic (???????) Spanish (español) Arabic (???????) Phenylketonuria or PKU English (Arabic) ???? ????? ??????? -- ??? ...

346

Medication Errors - Multiple Languages: MedlinePlus  

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... sharing features on this page, please enable JavaScript. Medication Errors - Multiple Languages Chinese - Simplified (????) Chinese - Traditional (????) Spanish (español) Chinese - Simplified (????) Proper Use of Medications English ?????????? - ???? (Chinese - Simplified) PDF Chinese Community ...

347

Use of autologous fat grafting for reconstruction postmastectomy and breast conserving surgery: a systematic review protocol  

PubMed Central

Introduction There is growing interest in the potential use of autologous fat grafting (AFG) for the purposes of breast reconstruction. However, concerns have been raised regarding the technique's clinical effectiveness, safety and interference with screening mammography. The objective of this systematic review was to determine the oncological, clinical, aesthetic and functional, patient reported, process and radiological outcomes for AFG. Methods and analysis All original studies, including randomised controlled trials, cohorts studies, case–control studies, case series and case reports involving women undergoing breast reconstruction. All AFG techniques performed for the purposes of reconstruction in the postmastectomy or breast conserving surgery setting will be considered. Outcomes are defined within this protocol along; oncological, clinical, aesthetic and functional, patient reported, process and radiological domains. The search strategy has been devised to find papers about ‘fat grafting and breast reconstruction’ and is outlined within the body of this protocol. The full search strategy is outlined within the body of the protocol. The following electronic databases will be searched from 1 January 1986 to 6 June 2013: PubMed, MEDLINE, EMBASE, SCOPUS, CINAHL, PsycINFO, SciELO, The Cochrane Library, including the Cochrane Database of Systematic Reviews (CDSR), Cochrane Central Register of Controlled Trials (CENTRAL), Database of Abstracts of Reviews of Effect (DARE), the Cochrane Methodology Register, Health Technology Assessment Database, the NHS Economic Evaluation Databases and Cochrane Groups, ClinicalTrials.gov, Current Controlled Trials Database, the World Health Organisation (WHO) International Clinical Trials Registry Platform, UpToDate.com, NHS Evidence and the York Centre for Reviews and Dissemination. Grey literature searches will also be conducted as detailed in our review protocol. Eligibility assessment occurred in two stages, title and abstract screening and then full text assessment. Data were extracted and stored in a database with standardised extraction fields to facilitate easy and consistent data entry. Ethics and dissemination This systematic review will be published in a peer-reviewed journal. It will also be presented at national and international conferences in the fields of plastic, reconstructive and aesthetic surgery and at more general surgical and methodological conferences. It will be disseminated electronically and in print. Brief reports of the review findings will be disseminated directly to the appropriate audiences of surgeons and societies through email and other modes of communication. Updates of the review will be conducted to inform and guide healthcare practice and policy. Protocol Registration PROSPERO—National Institute of Health Research (NIHR) Prospective Register of Systematic Reviews (CRD42013005254) PMID:24154518

Agha, Riaz A; Goodacre, Tim; Orgill, Dennis P

2013-01-01

348

Review of the Complications Associated with Treatment of Oropharyngeal Cancer: A Guide to the Dental Practitioner  

PubMed Central

Objectives Oropharyngeal cancer (OPC) is the 6th most common cancer worldwide. Focus on risk factors, improved diagnostic methods and effective management strategies have made it possible to successfully treat OPC. However, the 5-year survival rate has not improved for several years due to multiple treatment complications, tissue morbidity, loss of function and diminished quality of life. Survivors are faced with complications like oral mucositis, hyposalivation, osteoradionecrosis; tissue fibrosis, morbidity from jaw resection; disfigurement and loss of function that further diminish quality of life. The aim of this review is to highlight major complications associated with treatment of OPC via a literature search and review of available options for identification and management of these complications. Data Sources Relevant publications on oral complications of OPC therapy were thoroughly reviewed from the literature published between the years 1988 and 2012. Material and Method We evaluated reported incidence, prevalence and risk factors for oral complications of chemotherapy and radiotherapy for OPC. The authors conducted electronic search using English language databases namely PubMed Plus, Medline (Pre-Medline and Medline), Cochrane Database of systematic reviews (evidence-based medicine), Dentistry & Oral sciences source, AccessScience, Embase, Evidence-Based Medicine Reviews Multifile, Google Scholar, ISI Journal Citation Reports, Ovid Multi-Database. Conclusion We identified the most common complications associated with the treatment of oral cancers. Based on the information gathered, there is evidence that survival of OPC extends beyond eradication of the diseased tissue. Understanding the potential treatment complications and utilizing available resources to prevent and minimize them are important. Caring for OPC survivors should be a multidisciplinary team approach involving the dentist, oncologist, internist and social worker to improve the currently stagnant 5-year survival rate of OPC. More emphasis on improved quality of life after elimination of the cancer will ultimately improve OPC survivorship. PMID:23444208

Turner, Lena; Mupparapu, Muralidhar; Akintoye, Sunday O

2013-01-01

349

Medical eligibility criteria for new contraceptive methods: combined hormonal patch, combined hormonal vaginal ring and the etonogestrel implant  

Microsoft Academic Search

To review evidence on the combined hormonal patch, combined hormonal vaginal ring and the etonogestrel implant, with a focus on safety and effectiveness of use among women with special health conditions, we searched MEDLINE, Pre-MEDLINE and the Cochrane Library for reports published from 1980 through March 2005. Articles eligible for review included 11 on the hormonal patch, nine on the

Mary E. Gaffield; Kathryn M. Curtis; Anshu P. Mohllajee; Herbert B. Peterson

2006-01-01

350

NIH Quickfinder and NIH Medline Plus Advisory Group | NIH MedlinePlus the Magazine  

MedlinePLUS

... 800-4-CANCER (1-800-422-6237) National Eye Institute (NEI) www.nei.nih.gov (301) 496-5248 National Heart, Lung, and Blood Institute (NHLBI) www.nhlbi.nih.gov (301) 592-8573 National Human Genome Research Institute (NHGRI) www.genome.gov (301) ...

351

NIH Quickfinder and NIH Medline Plus Advisory Group | NIH MedlinePlus the Magazine  

MedlinePLUS

... ex-officio) Lakshmi Grama, National Cancer Institute Susan Johnson, National Institute of Dental and Craniofacial Research Thomas Johnson, National Institute of Biomedical Imaging and Bioengineering Kathy ...

352

Herbal Medications Commonly Used in the Practice of Rheumatology: Mechanisms of Action, Efficacy, and Side Effects  

Microsoft Academic Search

OBJECTIVE To review the literature on herbal preparations commonly utilized in the treatment of rheumatic indications. METHODS Search of MEDLINE (PubMed) was performed using both the scientific and the common names of herbs. Relevant articles in English were collected from PubMed and reviewed. RESULTS This review summarizes the efficacy and toxicities of herbal remedies used in complementary and alternative medical

Arathi R. Setty; Leonard H. Sigal

2005-01-01

353

Content-rich biological network constructed by mining PubMed abstracts  

Microsoft Academic Search

BACKGROUND: The integration of the rapidly expanding corpus of information about the genome, transcriptome, and proteome, engendered by powerful technological advances, such as microarrays, and the availability of genomic sequence from multiple species, challenges the grasp and comprehension of the scientific community. Despite the existence of text-mining methods that identify biological relationships based on the textual co-occurrence of gene\\/protein terms

Hao Chen; Burt M. Sharp

2004-01-01

354

Prioritizing PubMed articles for the Comparative Toxicogenomic Database utilizing semantic information  

PubMed Central

The Comparative Toxicogenomics Database (CTD) contains manually curated literature that describes chemical–gene interactions, chemical–disease relationships and gene–disease relationships. Finding articles containing this information is the first and an important step to assist manual curation efficiency. However, the complex nature of named entities and their relationships make it challenging to choose relevant articles. In this article, we introduce a machine learning framework for prioritizing CTD-relevant articles based on our prior system for the protein–protein interaction article classification task in BioCreative III. To address new challenges in the CTD task, we explore a new entity identification method for genes, chemicals and diseases. In addition, latent topics are analyzed and used as a feature type to overcome the small size of the training set. Applied to the BioCreative 2012 Triage dataset, our method achieved 0.8030 mean average precision (MAP) in the official runs, resulting in the top MAP system among participants. Integrated with PubTator, a Web interface for annotating biomedical literature, the proposed system also received a positive review from the CTD curation team. PMID:23160415

Wilbur, W. John

2012-01-01

355

Prioritizing PubMed articles for the Comparative Toxicogenomic Database utilizing semantic information.  

PubMed

The Comparative Toxicogenomics Database (CTD) contains manually curated literature that describes chemical-gene interactions, chemical-disease relationships and gene-disease relationships. Finding articles containing this information is the first and an important step to assist manual curation efficiency. However, the complex nature of named entities and their relationships make it challenging to choose relevant articles. In this article, we introduce a machine learning framework for prioritizing CTD-relevant articles based on our prior system for the protein-protein interaction article classification task in BioCreative III. To address new challenges in the CTD task, we explore a new entity identification method for genes, chemicals and diseases. In addition, latent topics are analyzed and used as a feature type to overcome the small size of the training set. Applied to the BioCreative 2012 Triage dataset, our method achieved 0.8030 mean average precision (MAP) in the official runs, resulting in the top MAP system among participants. Integrated with PubTator, a Web interface for annotating biomedical literature, the proposed system also received a positive review from the CTD curation team. PMID:23160415

Kim, Sun; Kim, Won; Wei, Chih-Hsuan; Lu, Zhiyong; Wilbur, W John

2012-01-01

356

A Systematic Review of the Effectiveness of Eccentric Strength Training in the Prevention of Hamstring Muscle Strains in Otherwise Healthy Individuals  

PubMed Central

Background Hamstring strains are the most common soft-tissue injury observed in recreational and athletic activities, yet no consensus exists regarding appropriate primary and secondary strategies to prevent these strains. Eccentric exercise has been reported to reduce the incidence of ham-string strains but its role has not been clearly defined. Objective The objective of this systematic review was to determine the effectiveness of eccentric exercise in preventing hamstring strains. Data Sources Online databases, including MED-LINE, PubMed, CINAHL, PEDro, SPORTDiscus, EMBASE, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, and Web of Science were searched for relevant articles. Each database was searched from the earliest date to July 2007. Study Selection Selection criteria included diagnosis of hamstring strain, otherwise healthy individuals, and at least one group receiving an eccentric exercise intervention. Seven articles {three randomized controlled trials (RCTs) and four cohort studies} met the inclusion criteria. Data Extraction Data were extracted using a customized form. Methodological rigor of included studies was assessed using the PEDro scale and Oxford Centre for Evidence-based Medicine Levels of Evidence. Data Synthesis Studies were grouped by eccentric exercise intervention protocol: hamstring lowers, isokinetic strengthening, and other strengthening. A best-evidence synthesis of pooled data was qualitatively summarized. Conclusions Findings suggest that eccentric training is effective in primary and secondary prevention of hamstring strains. Study heterogeneity and poor methodological rigor limit the ability to provide clinical recommendations. Further RCTs are needed to support the use of eccentric training protocols in the prevention of hamstring strains. PMID:21509129

Cheong, Krystie; Grant, Andrew; Beers, Amanda; Moizumi, Trevor

2008-01-01

357

Radiofrequency ablation for chronic low back pain: A systematic review of randomized controlled trials  

PubMed Central

BACKGROUND: Radiofrequency ablation (RFA), a procedure using heat to interrupt pain signals in spinal nerves, is an emerging treatment option for chronic low back pain. Its clinical efficacy has not yet been established. OBJECTIVE: To determine the efficacy of RFA for chronic low back pain associated with lumbar facet joints, sacroiliac joints, discogenic low back pain and the coccyx. METHODS: A systematic review was conducted. Medline, EMBASE, PubMed, SPORTDiscus, CINAHL and the Cochrane Library were searched up to August 2013. Abstracts and full-text articles were reviewed in duplicate. Included articles were sham-controlled randomized controlled trials (RCTs), assessed the efficacy of RFA, reported at least one month of follow-up and included participants who had experienced back pain for at least three months. Data were extracted in duplicate and quality was assessed using the Cochrane Risk of Bias tool. Due to heterogeneity, as well as a lack of reported mean differences and SDs, meta-analysis was not possible using these data. RESULTS: The present systematic review retrieved 1063 abstracts. Eleven sham-controlled RCTs were included: three studies involving discogenic back pain; six studies involving lumbar facet joint pain; and two studies involving sacroiliac joint pain. No studies were identified assessing the coccyx. The evidence supports RFA as an efficacious treatment for lumbar facet joint and sacroiliac joint pain, with five of six and both of the RCTs demonstrating statistically significant pain reductions, respectively. The evidence supporting RFA for the treatment of discogenic pain is mixed. CONCLUSIONS: While the majority of the studies focusing on lumbar facet joints and sacroiliac joints suggest that RFA significantly reduces pain in short-term follow-up, the evidence base for discogenic low back pain is mixed. There is no RCT evidence for RFA for the coccyx. Future studies should examine the clinical significance of the achieved pain reduction and the long-term efficacy of RFA. PMID:25068973

Leggett, Laura E; Soril, Lesley JJ; Lorenzetti, Diane L; Noseworthy, Tom; Steadman, Rodney; Tiwana, Simrandeep; Clement, Fiona

2014-01-01

358

Systematic Review of Acupuncture in Cancer Care: A Synthesis of the Evidence  

PubMed Central

Purpose Many cancer centers offer acupuncture services. To date, a comprehensive systematic review of acupuncture in cancer care has not been conducted. The purpose of this review was to evaluate the efficacy of acupuncture for symptom management in patients with cancer. Methods Medline, Embase, CINAHL, Cochrane (all databases), Scopus, and PubMed were searched from inception through December 2011 for prospective randomized clinical trials (RCT) evaluating acupuncture for symptom management in cancer care. Only studies involving needle insertion into acupuncture points were included. No language limitations were applied. Studies were assessed for risk of bias (ROB) according to Cochrane criteria. Outcomes by symptom were designated as positive, negative, or unclear. Results A total of 2,151 publications were screened. Of those, 41 RCTs involving eight symptoms (pain, nausea, hot flashes, fatigue, radiation-induced xerostomia, prolonged postoperative ileus, anxiety/mood disorders, and sleep disturbance) met all inclusion criteria. One positive trial of acupuncture for chemotherapy-induced nausea and vomiting had low ROB. Of the remaining studies, eight had unclear ROB (four positive, three negative, and one with unclear outcomes). Thirty-three studies had high ROB (19 positive, 11 negative, and three with both positive and negative outcomes depending on the symptom). Conclusion Acupuncture is an appropriate adjunctive treatment for chemotherapy-induced nausea/vomiting, but additional studies are needed. For other symptoms, efficacy remains undetermined owing to high ROB among studies. Future research should focus on standardizing comparison groups and treatment methods, be at least single-blinded, assess biologic mechanisms, have adequate statistical power, and involve multiple acupuncturists. PMID:23341529

Garcia, M. Kay; McQuade, Jennifer; Haddad, Robin; Patel, Sonya; Lee, Richard; Yang, Peiying; Palmer, J. Lynn; Cohen, Lorenzo

2013-01-01

359

Spinal manual therapy interventions for pediatric patients: a systematic review  

PubMed Central

Objective: Although much has been written about the efficacy of manual therapy interventions for adults with headaches or spinal pain, little research has focused on the use of these interventions in pediatric patients. The purpose of this systematic review was to evaluate the evidence for spinal manual therapy (SMT) interventions in patients 4–17 years old with headaches and/or mechanical spinal pain. Methods: A search for relevant studies published in the past 15 years was conducted on MEDLINE, CINAHL, Cochrane Central Register of Randomized Control Trials, PEDro, PubMed, and Sports Discus. Only English language articles were reviewed. Studies had to include at least one outcome measure for pain, function, or quality of life. Studies evaluating post-operative interventions, or those in which the interventions were directed at influencing excessive spinal curvatures, were excluded. Case reports and studies that did not limit analysis of the results to the pediatric population were also excluded. Results: Two randomized control trials and two studies offering lower levels of evidence were identified in the literature search. The latter studies were prospective cohort studies. The four studies were evaluated using the GRADE (Grading of Recommendations Assessment, Development and Evaluation) criteria. Discussion: There are very little data in the literature to support or refute the use of SMT interventions in pediatric patients. Further research is required to establish a strong evidence-based foundation for use of these interventions in children. PMID:23904755

Vaughn, Daniel W; Kenyon, Lisa K; Sobeck, Corey M; Smith, Robyn E

2012-01-01

360

Oral oncoprevention by phytochemicals - a systematic review disclosing the therapeutic dilemma.  

PubMed

The aim of this article is to emphasize and focus on the preclinical and clinical update on phytochemicals and their role in prevention of oral carcinogenesis. Accordingly, the literature search was made following database: Embase, Medline, Science Citation index, NIH public access, pubmed and Cochrane Database of systematic reviews. Several internet websites were also searched to access publications from major phytochemical research sites and relevant information was obtained with regards to each plant chemical. The authors also spotted different list servers through wignet.com, Stanford cancer research etc: The data base search was made from the inception to 1988 and updated till 2013. A systematic method was obtained for literature search and data collection was critiqued. 60 articles were searched, among which there were only 6 systematic reviews on phytochemicals regarding oral carcinogenesis. Additional articles were obtained on phytochemicals and their mechanism of action in other cancers, which were regarded as background material. The studies done by various authors on each phytochemical has been briefly emphasized. PMID:25364656

Bhavana, Sujana Mulk; Lakshmi, Chintamaneni Raja

2014-10-01

361

Treatment of American tegumentary leishmaniasis in special populations: a summary of evidence.  

PubMed

We aimed to assess and synthesize the information available in the literature regarding the treatment of American tegumentary leishmaniasis in special populations. We searched MEDLINE (via PubMed), EMBASE, LILACS, SciELO, Scopus, Cochrane Library and mRCT databases to identify clinical trials and observational studies that assessed the pharmacological treatment of the following groups of patients: pregnant women, nursing mothers, children, the elderly, individuals with chronic diseases and individuals with suppressed immune systems. The quality of evidence was assessed using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach. The available evidence suggests that the treatments of choice for each population or disease entity are as follows: nursing mothers and children (meglumine antimoniate or pentamidine), patients with renal disease (amphotericin B or miltefosine), patients with heart disease (amphotericin B, miltefosine or pentamidine), immunosuppressed patients (liposomal amphotericin), the elderly (meglumine antimoniate), pregnant women (amphotericinB) and patients with liver disease (no evidence available). The quality of evidence is low or very low for all groups. Accurate controlled studies are required to fi ll in the gaps in evidence for treatment in special populations. Post-marketing surveillance programs could also collect relevant information to guide treatment decision-making. PMID:24474006

Fontenele e Silva, Juliana Saboia; Galvao, Tais Freire; Pereira, Maurício Gomes; Silva, Marcus Tolentino

2013-01-01

362

Association of T174M polymorphism of angiotensinogen gene with essential hypertension: A meta-analysis.  

PubMed

The association between T174M polymorphism of angiotensinogen gene and essential hypertension risk remains controversial. We herein performed a meta-analysis to achieve a reliable estimation of their relationship. All the studies published up to May 2013 on the association between T174M polymorphism and essential hypertension risk were identified by searching the electronic repositories PubMed, MEDLINE and EMBASE, Springer, Elsevier Science Direct, Cochrane Library and Google Scholar. Data were extracted and pooled odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated. Ultimately, nine eligible studies, including 2188 essential hypertension cases and 2459 controls, were enrolled in this meta-analysis. No significant associations were found under the overall ORs for M-allele comparison (M vs. T, pooled OR 0.92, 95% CI 0.62-1.37), MM vs. TT (pooled OR 0.86, 95% CI 0.29-2.51), TM vs. TT n (pooled OR 0.91, 95% CI 0.63-1.32), recessive model (MM vs. TT+TM, pooled OR 0.89, 95% CI 0.35-2.30), dominant model (MM+TM vs. TT, pooled OR 0.91, 95% CI 0.60-1.38) between T174M polymorphism and risk for essential hypertension. This meta-analysis suggested that the T174M polymorphism of the angiotensinogen gene might not be associated with the susceptibility of essential hypertension in Asian or European populations. PMID:25249768

Liao, Xiaoyang; Yang, Zhiyi; Peng, Daqing; Dai, Hua; Lei, Yi; Zhao, Qian; Han, Yanbing; Wang, Weiwen

2014-09-01

363

Intramuscular Hemangiomas  

PubMed Central

Context: Intramuscular hemangiomas are common in the general population and often present at medical and surgical clinics. Unfortunately, unfamiliarity with these lesions has led to a high percentage of misdiagnoses, inappropriate workup, and unnecessary referrals. Evidence Acquisition: A literature search was performed using Medline, Embase, PubMed, and Cochrane. The relevant articles and referenced sources were reviewed for additional articles that discussed the epidemiology, pathophysiology, investigation, and management of intramuscular hemangiomas. Clinical experience from experts in orthopaedics, musculoskeletal pathology, and musculoskeletal radiology was compared. The selected case studies are shared cases of the authors. Results and Conclusion: The pathophysiology of these lesions is not completely understood, but much can be implied from their underlying vascular nature. Isolated lesions are benign tumors that never metastasize but tend to enlarge and then involute over time. Magnetic resonance imaging is the imaging modality of choice. If a systemic disorder or malignancy is not suspected or has been ruled out, conservative management is the treatment of choice for most intramuscular hemangiomas. PMID:24427416

Wierzbicki, Joseph M.; Henderson, Jeffrey H.; Scarborough, Mark T.; Bush, Charles H.; Reith, John D.; Clugston, James R.

2013-01-01

364

Therapy of HIV-associated lymphoma-recommendations of the oncology working group of the German Study Group of Physicians in Private Practice Treating HIV-Infected Patients (DAGNÄ), in cooperation with the German AIDS Society (DAIG).  

PubMed

AIDS-related aggressive B cell lymphoma (HIV-NHL) is the second most common HIV-associated malignancy. In contrast, Hodgkin-lymphoma (HL) is one of the most common non-AIDS-defining malignancies. Current evidence-based recommendations for the treatment of HIV-associated lymphoma (HIV-lymphoma) are not available. A panel of experts in the field of HIV-related lymphoma performed literature searches of the PubMed, Medline, and Cochrane databases. The consensus process was carried out as an e-mail and meeting-based discussion group. Six cycles of R-CHOP or R-EPOCH are standard of care for patients (pts) with diffuse large B cell lymphoma (DLBCL). Pts with Burkitt lymphoma and good performance status should receive dose-intensive regimens such as the GMALL B-ALL/NHL protocol. Standard therapy has not been defined for pts with plasmablastic and primary effusion lymphoma. Pts with lymphoma in sensitive relapse should receive high-dose chemotherapy followed by autologous stem cell transplantation. Stage- and risk adapted treatment yields high remission and survival rates in pts with HIV-HL similar to those achieved in HIV-negative HL pts. Combination antiretroviral therapy (cART) should be applied concurrently to chemotherapy provided that pharmacokinetic interactions are being considered. Pts with HIV-lymphoma should usually be treated in an identical manner to HIV-negative patients. PMID:24807241

Hentrich, Marcus; Hoffmann, Christian; Mosthaf, Franz; Müller, Markus; Siehl, Jan; Wyen, Christoph; Hensel, Manfred

2014-06-01

365

Lidocaine and Pain Management in the Emergency Department: A Review Article  

PubMed Central

Context: In the present review, the analgesic effects of lidocaine in acute or chronic painful conditions in the emergency department are discussed. Lidocaine, as a medium-acting local anesthetic with short onset time, is well-recognized, not only as a valuable medication for numerous neuropathic pain conditions, but also for the management of both acute and chronic pain. Evidence Acquisition: Research studies related to the different applications of lidocaine in the emergency department were collected from different databases including Cochrane library, Medline (Ovid) and PubMed. The pooled data were categorized, summarized and finally compared. Results: Our study revealed that lidocaine is broadly used in various therapeutic approaches for different types of pain, such as visceral/central pain, renal colic etc., in the emergency department. Conclusions: The antinociceptive properties of lidocaine are derived from multifaceted mechanisms, turning it into a medication that is safe to administer via different routes which makes it available for use in a variety of medical conditions. PMID:24660158

Golzari, Samad EJ; Soleimanpour, Hassan; Mahmoodpoor, Ata; Safari, Saeid; Ala, Alireza

2014-01-01

366

Effect of Medicinal Herbs on Primary Dysmenorrhoea- a Systematic Review  

PubMed Central

Conventional treatment for primary dysmenorrhoea has a failure rate of 20% to 25% and may be contraindicated or not tolerated by some women. Herbal medicine may be a suitable alternative. To determine the efficacy and safety of Iranian herbal medicine for primary dysmenorrhea when compared with placebo, no treatment, and other treatment. Electronic searches of the Cochrane Menstrual Disorders and Dysmenorrhoea Group Register of controlled trials, Scopus, Google Scholar, Medline, Pubmed were performed to identify relevant randomized controlled trials (RCTs). The study abstraction and quality assessment of all studies were undertaken following the detailed descriptions of these categories as described in the JADAD Criteria for Systematic Reviews of Interventions. 25 RCTs involving a total of women were included in the review. The review found promising evidence in the form of RCTs for the use of herbal medicine in the treatment of primary dysmenorrhoea compared with pharmacological treatment. However, the results were limited by methodological flaws. Further rigorous no penetrating placebo-controlled RCTs are warranted. The review found promising evidence supporting the use of herbal medicine for primary dysmenorrhoea; however, results are limited by the poor methodological quality of the included trials.

Mirabi, Parvaneh; Alamolhoda, Seideh Hanieh; Esmaeilzadeh, Seddigheh; Mojab, Faraz

2014-01-01

367

Delirium in Hospitalized Patients: Implications of Current Evidence on Clinical Practice and Future Avenues for Research--A Systematic Evidence Review  

PubMed Central

BACKGROUND Despite the significant burden of delirium among hospitalized adults, critical appraisal of systematic data on delirium diagnosis, pathophysiology, treatment, prevention, and outcomes is lacking. PURPOSE To provide evidence-based recommendations for delirium care to practitioners, and identify gaps in delirium research. DATA SOURCES Medline, PubMed, the Cochrane Library, and the Cumulative Index to Nursing and Allied Health Literature (CINAHL) information systems fromJanuary 1966 to April 2011. STUDY SELECTION All published systematic evidence reviews (SERs) on delirium were evaluated. DATA EXTRACTION Three reviewers independently extracted the data regarding delirium risk factors, diagnosis, prevention, treatment, and outcomes, and critically appraised each SER as good, fair, or poor using the United States Preventive Services Task Force criteria. DATA SYNTHESIS Twenty-two SERs graded as good or fair provided the data. Age, cognitive impairment, depression, anticholinergic drugs, and lorazepam use were associated with an increased risk for developing delirium. The Confusion Assessment Method (CAM) is reliable for delirium diagnosis outside of the intensive care unit. Multicomponent nonpharmacological interventions are effective in reducing delirium incidence in elderly medical patients. Low-dose haloperidol has similar efficacy as atypical antipsychotics for treating delirium. Delirium is associated with poor outcomes independent of age, severity of illness, or dementia. CONCLUSION Delirium is an acute, preventable medical condition with short- and long-term negative effects on a patient’s cognitive and functional states. PMID:22684893

Khan, Babar A.; Zawahiri, Mohammed; Campbell, Noll L.; Fox, George C.; Weinstein, Eric J.; Nazir, Arif; Farber, Mark O.; Buckley, John D.; MacLullich, Alasdair; (UK), MRCP; Boustani, Malaz A.

2013-01-01

368

Chemistry, Pharmacology, and Toxicology of Khat (Catha Edulis Forsk): A Review  

PubMed Central

Catha edulis (khat) is a plant grown commonly in the horn of Africa. The leaves of khat are chewed by the people for its stimulant action. Its young buds and tender leaves are chewed to attain a state of euphoria and stimulation. Khat is an evergreen shrub, which is cultivated as a bush or small tree. The leaves have an aromatic odor. The taste is astringent and slightly sweet. The plant is seedless and hardy, growing in a variety of climates and soils. Many different compounds are found in khat including alkaloids, terpenoids, flavonoids, sterols, glycosides, tannins, amino acids, vitamins and minerals. The phenylalkylamines and the cathedulins are the major alkaloids which are structurally related to amphetamine. The major effects of khat include those on the gastro-intestinal system and on the nervous system. Constipation, urine retention and acute cardiovascular effects may be regarded as autonomic (peripheral) nervous system effects; increased alertness, dependence, tolerance and psychiatric symptoms as effects on the central nervous system. The main toxic effects include increased blood pressure, tachycardia, insomnia, anorexia, constipation, general malaise, irritability, migraine and impaired sexual potency in men. Databases such as Pubmed, Medline, Hinary, Google search, Cochrane and Embase were systematically searched for literature on the different aspects of khat to summarize chemistry, pharmacology, toxicology of khat (Catha edulis Forsk). PMID:24494129

Wabe, Nasir Tajure

2011-01-01

369

Transvaginal cervical cerclage: evidence for perioperative management strategies.  

PubMed

The objective was to review the evidence supporting various perioperative technical and management strategies for transvaginal cervical cerclage. We performed MEDLINE, PubMed, EMBASE, and COCHRANE searches with the terms, cerclage, cervical cerclage, cervical insufficiency, and randomized trials, plus each technical aspect (eg, suture, amniocentesis, etc) considered. The search spanned 1966 through September 2012 and was not restricted by language. Each retrieved manuscript was carefully evaluated, and any pertinent references from the reports were also obtained and reviewed. All randomized trials covering surgical and selected perioperative, nonsurgical aspects of cerclage were included in the review. The evidence was assessed separately for history-, ultrasound-, and physical examination-indicated cerclage. Evidence levels according to the new method outlined by the US Preventive Services Task Force were assigned based on the evidence. There are no grade A high-certainty recommendations regarding technical aspects of transvaginal cervical cerclage. Grade B moderate-certainty recommendations include performing a fetal ultrasound before cerclage to ensure fetal viability, confirm gestational age, and assess fetal anatomy to rule out clinically significant structural abnormalities; administering spinal, and not general, anesthesia; performing a McDonald cerclage, with 1 stitch, placed as high as possible; and outpatient setting. Unfortunately, no other recommendations can be made regarding the other technical aspects of cerclage. PMID:23416155

Berghella, Vincenzo; Ludmir, Jack; Simonazzi, Giuliana; Owen, John

2013-09-01

370

Imperative Role of Dental Pulp Stem Cells in Regenerative Therapies: A Systematic Review  

PubMed Central

Stem cells are primitive cells that can differentiate and regenerate organs in different parts of the body such as heart, bones, muscles and nervous system. This has been a field of great clinical interest with immense possibilities of using the stem cells in regeneration of human organ those are damaged due to disease, developmental defects and accident. The knowledge of stem cell technology is increasing quickly in all medical specialties and in dental field too. Stem cells of dental origin appears to hold the key to various cell-based therapies in regenerative medicine, but most avenues are in experimental stages and many procedures are undergoing standardization and validation. Long-term preservation of SHED cells or DPSC is becoming a popular consideration, similar to the banking of umbilical cord blood. Dental pulp stem cells (DPSCs) are the adult multipotent cells that reside in the cell rich zone of the dental pulp. The multipotent nature of these DPSCs may be utilized in both dental and medical applications. A systematic review of the literature was performed using various internet based search engines (PubMed, Medline Plus, Cochrane, Medknow, Ebsco, Science Direct, Hinari, WebMD, IndMed, Embase) using keywords like “dental pulp stem cells”, “regeneration”, “medical applications”, “tissue engineering”. DPSCs appears to be a promising innovation for the re-growth of tissues however, long term clinical studies need to be carried out that could establish some authentic guidelines in this perspective. PMID:24665194

Kabir, Ramchandra; Gupta, Manish; Aggarwal, Avanti; Sharma, Deepak; Sarin, Anurag; Kola, Mohammed Zaheer

2014-01-01

371

Assisted Reproductive Technology after the Birth of Louise Brown  

PubMed Central

Background Public interest in Assisted Reproductive Technology (ART) has remained high since the birth of the world’s first in vitro fertilization baby, Louise Brown, in the United Kingdom. ART allows scientists to manipulate the fertilization process in order to bypass some pathological obstacles such as blocked fallopian tubes and non-functioning ovaries in the females, and blocked vas deferens and low sperm count in the males. The purpose was to provide a historical outline and identify the researches that most contributed to ART. Methods A review of published experimental and clinical studies of assisted reproduction carried out at the University of Bristol library website (MetaLib®). A cross-search of seven different medical databases (AMED-Allied and Complementary Medicine Database, BIOSIS Previews on Web of Knowledge, Cochrane Library, Embase, and the Medline on Web of Knowledge, OvidSP and PubMed) was completed by using the key words to explore the major milestones and progress in the development and implementation of ART. Results A speedy advancement in the development of different assisted reproductive techniques makes infertility problem more treatable than it ever had been. Conclusion Although no other field in the medicine has integrated new knowledge into the daily practice more quickly than ART yet, there is a need for social research to counterbalance the dominance of biomedical one, in particular the people’s actual experiences and expectations of ART. PMID:24163793

Kamel, Remah Moustafa

2013-01-01

372

Ligasure versus stapled hemorrhoidectomy in the treatment of hemorrhoids: a meta-analysis of randomized control trials.  

PubMed

The aim of this meta-analysis was to compare the outcomes of Ligasure hemorrhoidectomy and stapled hemorrhoidectomy for prolapsed hemorrhoids. Original studies in any language were searched from MEDLINE database, PubMed, Web of science and the Cochrane Library database, and Wangfang database. Randomized control trials that compared Ligasure hemorrhoidectomy with stapled hemorrhoidectomy were identified. Data were extracted independently for each study, and a meta-analysis was performed using fixed and random-effects models. Five trials including 397 patients met the inclusion criteria. Patients treated with Ligasure had a significantly shorter operative time compared with patients who underwent stapler techniques. The recurrence rate was higher in patients who underwent stapled hemorrhoidectomy. No statistically significant differences were observed in postoperative bleeding, urinary retention, difficult defecating, anal fissure, anal stenosis, incontinence, postoperative pain, return to normal activities, and hospital stay. Our meta-analysis shows that Ligasure is an effective instrument for hemorrhoidectomy, which results in shorter operation time and lower recurrence rate. PMID:24732739

Chen, Hong-lei; Woo, Xiao-bin; Cui, Ji; Chen, Chuang-qi; Peng, Jun-sheng

2014-08-01

373

Ponseti method compared with soft-tissue release for the management of clubfoot: A meta-analysis study  

PubMed Central

AIM: To compare the functional outcomes of patients who underwent open surgery vs Ponseti method for the management of idiopathic clubfoot and to determine whether correlations exist between functional outcome and radiographic measurements. METHODS: A meta-analysis of the literature was conducted for studies concerning primary treatment of patients with idiopathic clubfoot. We searched PubMed Medline, EMBASE, and the Cochrane Library databases from January 1950 to October 2011. Meta-analyses were performed on outcomes from 12 studies. Pooled means, SDs, and sample sizes were either identified in the results or calculated based on the results of each study. RESULTS: Overall, 835 treated idiopathic clubfeet in 516 patients were reviewed. The average follow-up was 15.7 years. Patients managed with Ponseti method did have a higher rate of excellent or good outcome than patients treated with open surgery (0.76 and 0.62, respectively), but not quite to the point of statistical significance (Q = 3.73, P = 0.053). Age at surgery was not correlated with the functional outcome for the surgically treated patients (r = -0.32, P = 0.68). A larger anteroposterior talocalcaneal angle was correlated with a higher rate of excellent or good outcomes (r = 0.80, P = 0.006). There were no other significant correlations between the functional and radiographic outcomes. CONCLUSION: The Ponseti method should be considered the initial treatment of idiopathic clubfeet, and open surgery should be reserved for clubfeet that cannot be completely corrected. PMID:23878784

Lykissas, Marios G; Crawford, Alvin H; Eismann, Emily A; Tamai, Junichi

2013-01-01

374

Brachial plexus anatomy: normal and variant.  

PubMed

Effective brachial plexus blockade requires a thorough understanding of the anatomy of the plexus, as well as an appreciation of anatomic variations that may occur. This review summarizes relevant anatomy of the plexus, along with variations and anomalies that may affect nerve blocks conducted at these levels. The Medline, Cochrane Library, and PubMed electronic databases were searched in order to compile reports related to the anatomy of the brachial plexus using the following free terms: "brachial plexus", "median nerve", "ulnar nerve", "radial nerve", "axillary nerve", and "musculocutanous nerve". Each of these was then paired with the MESH terms "anatomy", "nerve block", "anomaly", "variation", and "ultrasound". Resulting articles were hand searched for additional relevant literature. A total of 68 searches were conducted, with a total of 377 possible articles for inclusion. Of these, 57 were found to provide substantive information for this review. The normal anatomy of the brachial plexus is briefly reviewed, with an emphasis on those features revealed by use of imaging technologies. Anomalies of the anatomy that might affect the conduct of the various brachial plexus blocks are noted. Brachial plexus blockade has been effectively utilized as a component of anesthesia for upper extremity surgery for a century. Over that period, our understanding of anatomy and its variations has improved significantly. The ability to explore anatomy at the bedside, with real-time ultrasonography, has improved our appreciation of brachial plexus anatomy as well. PMID:19412559

Orebaugh, Steven L; Williams, Brian A

2009-01-01

375

Exercise during childhood and adolescence: a prophylaxis against cystic fibrosis-related low bone mineral density? Exercise for bone health in children with cystic fibrosis.  

PubMed

Inadequate bone mineral accrual during growth and accelerated bone demineralisation in adulthood are recognised as additional and serious complications for patients with cystic fibrosis (CF). However, little attention has been given to preventative strategies for this population. Inadequate bone accrual during childhood and adolescence, and premature bone loss, lead to a failure to attain an optimal peak bone mass, osteoporosis and fracture in patients with CF. Pharmaceutical treatments may assist in the improvement of bone in patients with CF, but these are usually not preferable for use in children. Evidence indicates that regular, weight-bearing exercise significantly enhances bone accrual in healthy children. This paper reviews the literature concerning the potential for weight-bearing exercise to improve bone mineral accrual in children with CF. All relevant literature since 1979 was obtained and reviewed from the Medline, PubMed, Cochrane and PEDro data base. Evidence concerning the efficacy of exercise for bone health in CF is lacking. There have been no controlled trials investigating the value of weight-bearing exercise for bone accrual in children with CF. As exercise may offer an effective and enjoyable strategy to improve the bone development in children who have CF, exercise should be a high priority for randomised controlled trials in this population. PMID:18378195

Hind, K; Truscott, J G; Conway, S P

2008-07-01

376

A systematic review of randomized controlled trials on curative and health enhancement effects of forest therapy  

PubMed Central

Objective To summarize the evidence for curative and health enhancement effects through forest therapy and to assess the quality of studies based on a review of randomized controlled trials (RCTs). Study design A systematic review based on RCTs. Methods Studies were eligible if they were RCTs. Studies included one treatment group in which forest therapy was applied. The following databases – from 1990 to November 9, 2010 – were searched: MEDLINE via PubMed, CINAHL, Web of Science, and Ichushi- Web. All Cochrane databases and Campbell Systematic Reviews were also searched up to November 9, 2010. Results Two trials met all inclusion criteria. No specific diseases were evaluated, and both studies reported significant effectiveness in one or more outcomes for health enhancement. However, the results of evaluations with the CONSORT (Consolidated Standards of Reporting Trials) 2010 and CLEAR NPT (A Checklist to Evaluate a Report of a Nonpharmacological Trial) checklists generally showed a remarkable lack of description in the studies. Furthermore, there was a problem of heterogeneity, thus a meta-analysis was unable to be performed. Conclusion Because there was insufficient evidence on forest therapy due to poor methodological and reporting quality and heterogeneity of RCTs, it was not possible to offer any conclusions about the effects of this intervention. However, it was possible to identify problems with current RCTs of forest therapy, and to propose a strategy for strengthening study quality and stressing the importance of study feasibility and original check items based on characteristics of forest therapy as a future research agenda. PMID:22888281

Kamioka, Hiroharu; Tsutani, Kiichiro; Mutoh, Yoshiteru; Honda, Takuya; Shiozawa, Nobuyoshi; Okada, Shinpei; Park, Sang-Jun; Kitayuguchi, Jun; Kamada, Masamitsu; Okuizumi, Hiroyasu; Handa, Shuichi

2012-01-01

377

Effectiveness of animal-assisted therapy: A systematic review of randomized controlled trials.  

PubMed

The objectives of this review were to summarize the evidence from randomized controlled trials (RCTs) on the effects of animal-assisted therapy (AAT). Studies were eligible if they were RCTs. Studies included one treatment group in which AAT was applied. We searched the following databases from 1990 up to October 31, 2012: MEDLINE via PubMed, CINAHL, Web of Science, Ichushi Web, GHL, WPRIM, and PsycINFO. We also searched all Cochrane Database up to October 31, 2012. Eleven RCTs were identified, and seven studies were about "Mental and behavioral disorders". Types of animal intervention were dog, cat, dolphin, bird, cow, rabbit, ferret, and guinea pig. The RCTs conducted have been of relatively low quality. We could not perform meta-analysis because of heterogeneity. In a study environment limited to the people who like animals, AAT may be an effective treatment for mental and behavioral disorders such as depression, schizophrenia, and alcohol/drug addictions, and is based on a holistic approach through interaction with animals in nature. To most effectively assess the potential benefits for AAT, it will be important for further research to utilize and describe (1) RCT methodology when appropriate, (2) reasons for non-participation, (3) intervention dose, (4) adverse effects and withdrawals, and (5) cost. PMID:24731910

Kamioka, Hiroharu; Okada, Shinpei; Tsutani, Kiichiro; Park, Hyuntae; Okuizumi, Hiroyasu; Handa, Shuichi; Oshio, Takuya; Park, Sang-Jun; Kitayuguchi, Jun; Abe, Takafumi; Honda, Takuya; Mutoh, Yoshiteru

2014-04-01

378

Shoulder injuries in soccer players.  

PubMed

Even though soccer is the most popular sport of the world, no review is available at present to resume the available data on shoulder injuries in soccer. The aim of this review is to report the available epidemiological data on shoulder specific injuries in soccer players and to describe the common mechanisms of shoulder injuries in soccer. Studies published through September 15, 2011, were identified by using MEDLINE, EMBASE, CINAHL and Pre-CINAHL, Pub-Med, Web of Science, and the full Cochrane Library. Reference lists of included studies were searched by hand. Studies were included if they reported on shoulder injuries in soccer players. Limits were not placed on year of publication, status of publication, or language. The journal, authors, and author affiliations of included studies were masked from 2 reviewers. We planned to perform a study on the epidemiology, mechanisms and management of shoulder injuries in elite soccer players. We also planned to use Review Manager (RevMan. Version 5 for Windows) to calculate the magnitude of treatment effect. No studies on clinical outcome of shoulder injuries in elite soccer athletes were found. No studies on the mechanism of shoulder injury in elite soccer players were found. The results of the available studies on epidemiology are reported. Despite soccer is the world's game, few studies focused on shoulder injuries in soccer players, and therefore no definitive conclusions can be drawn. Further research is warranted to clarify the epidemiology, mechanisms and management of shoulder injuries in elite soccer players. PMID:23289025

Longo, Umile Giuseppe; Loppini, Mattia; Berton, Alessandra; Martinelli, Nicolò; Maffulli, Nicola; Denaro, Vincenzo

2012-09-01

379

A Review of Web Based Interventions for Managing Tobacco Use  

PubMed Central

Web based interventions (WBIs) have been developed for various health conditions. These include interventions for various psychoactive substance use disorders including tobacco and alcohol. Tobacco use has remained the single largest preventable cause of global mortality and morbidity for many years. It is responsible for around 6 million deaths annually world-wide. Ironically, most of the tobacco users reside in resource poor low and middle-income countries. The article reviews the existing literature on WBIs for management of tobacco use. The literature search was performed using MedLine, PubMed, PsycINFO, Embase and Cochrane Review for relevant English language articles published from 1998 up to 2013. There is limited support for effectiveness of WBIs for managing tobacco use among adolescents. Although most of the trials among adults found WBIs to be more effective at short term follow-up (a few days to weeks), the benefits failed to extend beyond 3 months in most of the studies. All but one interventions studied in a randomized controlled trial is for smoking forms. PMID:25035543

Balhara, Yatan Pal Singh; Verma, Rohit

2014-01-01

380

Sport injuries: a review of outcomes.  

PubMed

Injuries can counter the beneficial aspects related to sports activities if an athlete is unable to continue to participate because of residual effects of injury. We provide an updated synthesis of existing clinical evidence of long-term follow-up outcome of sports injuries. A systematic computerized literature search was conducted on following databases were accessed: PubMed, Medline, Cochrane, CINAHL and Embase databases. At a young age, injury to the physis can result in limb deformities and leg-length discrepancy. Weight-bearing joints including the hip, knee and ankle are at risk of developing osteoarthritis (OA) in former athletes, after injury or in the presence of malalignment, especially in association with high impact sport. Knee injury is a risk factor for OA. Ankle ligament injuries in athletes result in incomplete recovery (up to 40% at 6 months), and OA in the long term (latency period more than 25 years). Spine pathologies are associated more commonly with certain sports (e.g. wrestling, heavy-weight lifting, gymnastics, tennis, soccer). Evolution in arthroscopy allows more accurate assessment of hip, ankle, shoulder, elbow and wrist intra-articular post-traumatic pathologies, and possibly more successful management. Few well-conducted studies are available to establish the long-term follow-up of former athletes. To assess whether benefits from sports participation outweigh the risks, future research should involve questionnaires regarding the health-related quality of life in former athletes, to be compared with the general population. PMID:20710023

Maffulli, Nicola; Longo, Umile Giuseppe; Gougoulias, Nikolaos; Caine, Dennis; Denaro, Vincenzo

2011-01-01

381

Silodosin for the treatment of clinical benign prostatic hyperplasia: safety, efficacy, and patient acceptability  

PubMed Central

?1-Adrenergic receptor antagonists are commonly used to treat male lower urinary tract symptoms and benign prostatic hyperplasia (BPH). We performed a literature search using PubMed, Medline via Ovid, Embase, and the Cochrane Library databases to identify studies on the treatment of BPH by silodosin. Silodosin is a novel ?1-adrenergic receptor antagonist whose affinity for the ?1A-adrenergic receptor is greater than that for the ?1B-adrenergic receptor. Therefore, silodosin does not increase the incidence of blood pressure-related side effects, which may result from the inhibition of the ?1B-adrenergic receptor. Patients receiving silodosin at a daily dose of 8 mg showed a significant improvement in the International Prostate Symptom Score and maximum urinary flow rate compared with those receiving a placebo. Silodosin also improved both storage and voiding symptoms, indicating that silodosin is effective, even during early phases of BPH treatment. Follow-up extension studies performed in the United States, Europe, and Asia demonstrated its long-term safety and efficacy. In the European study, silodosin significantly reduced nocturia compared to the placebo. Although retrograde or abnormal ejaculation was the most commonly reported symptom in these studies, only a few patients discontinued treatment. The incidence of adverse cardiovascular events was also very low. Evidence showing solid efficacy and cardiovascular safety profiles of silodosin will provide a good solution for the treatment of lower urinary tract symptoms associated with BPH in an increasingly aging society. PMID:25328864

Cho, Hee Ju; Yoo, Tag Keun

2014-01-01

382

Is there muscular weakness in Parkinson's disease?  

PubMed

Controversy exists as to whether muscle weakness is present in Parkinson's disease (PD). Computerized literature searches identified clinical trials and reviews about muscular strength assessment in patients with Parkinson's disease, using the following databases: PubMed, Ovid MEDLINE, Ovid EMBASE, the Cochrane Database of Systematic Reviews, Cumulative Index to Nursing and Allied Health Literature, and Physiotherapy Evidence Database. Seventeen articles fulfilled all criteria for selection. These studies suggested that isokinetic muscle strength was decreased in patients with Parkinson's disease and that muscle weakness was not specifically related to tremor or rigidity. Bilateral asymmetrical muscle weakness was present in Parkinson's disease when presenting with clinical unilateral hemiparkinsonism. Recent studies using sensitive mechanical devices have provided evidence that muscle strength is reduced in patients with Parkinson's disease compared with age-matched controls. The specific cause of this weakness is not known. Questions under debate were whether this weakness was of central or peripheral origin and whether it was intrinsic to the disease or a secondary phenomenon. PMID:19487924

Cano-de-la-Cuerda, Roberto; Pérez-de-Heredia, Marta; Miangolarra-Page, Juan Carlos; Muñoz-Hellín, Elena; Fernández-de-Las-Peñas, Cesar

2010-01-01

383

The Effects of Baclofen for the Treatment of Gastroesophageal Reflux Disease: A Meta-Analysis of Randomized Controlled Trials  

PubMed Central

Objectives. Baclofen can relieve gastroesophageal reflux-related symptoms in healthy subjects and gastroesophageal reflux disease (GERD) patients by reducing the incidence of transient lower esophageal sphincter relaxation. This meta-analysis aimed to evaluate the efficacy and safety of baclofen for the treatment of GERD. Methods. We systematically searched randomized controlled trials published prior to November 2013 from PubMed, Medline, Embase, ScienceDirect, ClinicalTrials.gov, and the Cochrane Central Register of Randomized Controlled Trials. We performed a meta-analysis of all eligible trials. Results. Nine studies were identified with a total of 283 GERD patients and healthy subjects. Comparative analysis provided high quality data supporting the ability of baclofen to promote a short-term decrease in the number of reflux episodes per patient, the average length of reflux episodes, and the incidence of transient lower esophageal sphincter relaxation. No serious adverse events or death events were reported, and there were no significant differences in the overall adverse events between baclofen and placebo. All reported side effects of baclofen were of mild-to-moderate intensity, and the drug was well tolerated. Conclusion. Abundant evidence suggests that baclofen may be a useful approach for the treatment of GERD patients; however, a larger well-designed research study would further confirm this recommendation. PMID:25389436

Li, Shujie; Shi, Shengying; Chen, Feng; Lin, Jingming

2014-01-01

384

Lung volume reduction surgery: an overview.  

PubMed

This study intends to review the literature on the efficacy, safety and feasibility of lung volume reduction surgery (LVRS) in patients with advanced emphysema. Studies on LVRS from January 1995 to December 2009 were included by using Pubmed (MEDLINE) and Cochrane Library literature in English. Search words such as lung volume reduction surgery or lung reduction surgery, pneumoplasty or reduction pneumoplasty, COPD or chronic obstructive pulmonary disease and surgery, were used. We also compared medical therapy and surgical technique. Studies consisting of randomized controlled trials, controlled clinical trials (randomized and nonrandomized), reviews and case series were analyzed. Questions regarding validity of the early clinical reports, incomplete follow-up bias, selection criteria and survival, confounded the interpretation of clinical data on LVRS. Patients with upper, lower and diffuse distribution of emphysema were included; we also analyzed as key points perioperative morbidity and mortality and lung function measurement as FEV1. Bullous emphysema was excluded from this review. Surgical approach included median sternotomy, unilateral or bilateral thoracotomy, and videothoracoscopy with stapled or laser ablation. Results of prospective randomized trials between medical management and LVRS are essential before final assessment can be established. PMID:21271143

Sardenberg, Rodrigo Afonso da Silva; Younes, Riad Naim; Deheizelin, Daniel

2010-01-01

385

Entry Complications in Laparoscopic Surgery  

PubMed Central

To review the complications associated with laparoscopic surgery and provide clinical direction regarding the best practice based on the best available evidence. The laparoscopic entry techniques and technologies reviewed include the classic pneumoperitoneum (Veress/trocar), the open (Hasson), the direct trocar insertion, the use of disposable shielded trocars, radially expanding trocars and visual entry systems. Medline, Pubmed and Cochrane Databases were searched for English language articles published before December 2008. It is an evidence based fact that minimal access surgery is superior to conventional open surgery since this is beneficial to the women, community and the healthcare system.Over the past 50 years, many techniques, technologies and guidelines have been introduced to eliminate the risks associated with laparoscopic entry. No single technique or instrument has been proved to eliminate laparoscopic entry associated injury. Proper evaluation of the women, supported by surgical skills and good knowledge of the technology and instrumentation is the keystone to safe access and prevention of complications during laparoscopic surgery. PMID:22442503

Krishnakumar, S; Tambe, P

2009-01-01

386

Prevalence of nontuberculous mycobacteria in patients with bronchiectasis: a meta-analysis  

PubMed Central

Introduction Nontuberculous mycobacteria (NTM) have emerged as critical opportunistic pathogens of lung diseases recently. Patients with preexisting bronchiectasis are susceptible to NTM. Nevertheless, patients with preexisting bronchiectasis are susceptible to NTM but the prevalence of NTM pulmonary infection in different species and geographical areas is still not fully understood. Material and methods The relevant data of the prevalence of NTM in patients with bronchiectasis were retrieved by searching the main databases such as PubMed, MEDLINE, Cochrane Library, and EMBASE. This meta-analysis was performed using Rev. Man 5.1 and Stata 11.0 software. The collected information of NTM prevalence was chosen as the effect size. Results The results of the meta-analysis showed that the overall prevalence of NTM was 9.3% in patients with bronchiectasis. The further stratification of subgroup analysis indicated that the combined prevalence of NTM was higher in studies whose “sample size” was more than or equal to 100 (p = 0.002), in studies in which “time of study” was after or equal to 2002 (p < 0.001), in studies in which “participants’ geographic location” was Asian (p < 0.001) and in studies whose “method of study” was retrospective (p = 0.002) as well, compared with corresponding groups. Conclusions Our findings suggested that the prevalence NTM infection is high in patients with bronchiectasis. A larger number of definitive randomized trials are still required to assess this research issue.

Chu, Haiqing; Zhao, Lan; Zhang, Jinbo; Gui, Tao; Gong, Sugang; Xu, Liyun; Sun, Xiwen

2014-01-01

387

Focal cryotherapy of localized prostate cancer: a systematic review of the literature.  

PubMed

Radical/whole gland treatment for prostate cancer has significant side-effects. Therefore focal treatments such as cryotherapy have been used to treat localized lesions whilst aiming to provide adequate cancer control with minimal side-effects. We performed a systematic review of Pubmed/Medline and Cochrane databases' to yield 9 papers for primary focal prostate cryotherapy and 2 papers for focal salvage treatment (radio-recurrent). The results of 1582 primary patients showed biochemical disease-free survival between 71-93% at 9-70 months follow-up. Incontinence rates were 0-3.6% and ED 0-42%. Recto-urethral fistula occurred in only 2 patients. Salvage focal cryotherapy had biochemical disease-free survival of 50-68% at 3 years. ED occurred in 60-71%. Focal cryotherapy appears to be an effective treatment for primary localized prostate cancer and compares favorably to radical/whole gland treatments in medium-term oncological outcomes and side-effects. Although more studies are needed it is also effective for radio-recurrent cancer with a low complications rates. PMID:25367324

Shah, Taimur Tariq; Ahmed, Hashim; Kanthabalan, Abi; Lau, Benjamin; Ghei, Maneesh; Maraj, Barry; Arya, Manit

2014-11-01

388

Therapeutic Effect and Safety of Ustekinumab for Plaque Psoriasis: A Meta-analysis.  

PubMed

Objective To evaluate the efficacy and safety of ustekinumab in the therapy of plaque psoriasis. Methods Literatures published up to November 2013 were collected from Cochrane library, MEDLINE, and PubMed which were related with ustekinumab for plaque psoriasis. The efficacy was estimated using relative risk of Psoriasis Area and Severity Index (PASI) 75 response rate at the week 12 endpoint in clinical trials, and adverse effects were also analyzed. Meta-analysis was carried out by using Review Manager 5.1. Results Six randomized control trials consistent with the inclusion criteria were selected and reviewed. Ustekinumab 45 mg group and 90 mg group could get better therapeutic effect compared with the placebo group (all P<0.00001). Furthermore, ustekinumab 90 mg group was more effective than ustekinumab 45 mg group (P=0.01). Adverse effects in the 6 trials were mentioned including headache, upper respiratory tract infection, nasopharyngtis, infection, serious infection, cardiovascular events, and malignant tumors. There were no statistically significant differences of these adverse effects among three groups (all P>0.05), except that infection rate in ustekinumab 45 mg group was higher than the placebo group (P=0.02). Conclusions Ustekinumab is an effective and safe therapeutic method for plaque psoriasis. However, further longer time analysis of safety is needed. PMID:25264879

Liu, Yi; Gong, Jian-Ping; Li, Wen-Fang

2014-09-29

389

Effect of medicinal herbs on primary dysmenorrhoea- a systematic review.  

PubMed

Conventional treatment for primary dysmenorrhoea has a failure rate of 20% to 25% and may be contraindicated or not tolerated by some women. Herbal medicine may be a suitable alternative. To determine the efficacy and safety of Iranian herbal medicine for primary dysmenorrhea when compared with placebo, no treatment, and other treatment. Electronic searches of the Cochrane Menstrual Disorders and Dysmenorrhoea Group Register of controlled trials, Scopus, Google Scholar, Medline, Pubmed were performed to identify relevant randomized controlled trials (RCTs). The study abstraction and quality assessment of all studies were undertaken following the detailed descriptions of these categories as described in the JADAD Criteria for Systematic Reviews of Interventions. 25 RCTs involving a total of women were included in the review. The review found promising evidence in the form of RCTs for the use of herbal medicine in the treatment of primary dysmenorrhoea compared with pharmacological treatment. However, the results were limited by methodological flaws. Further rigorous no penetrating placebo-controlled RCTs are warranted. The review found promising evidence supporting the use of herbal medicine for primary dysmenorrhoea; however, results are limited by the poor methodological quality of the included trials. PMID:25276177

Mirabi, Parvaneh; Alamolhoda, Seideh Hanieh; Esmaeilzadeh, Seddigheh; Mojab, Faraz

2014-01-01

390

A systematic review of the literature on 'medication wastage': an exploration of causative factors and effect of interventions.  

PubMed

Introduction Reducing any wastage, including that of medications, is a paramount objective in promoting appropriate utilisation of finite resources. The objective was to systematically review the published literature, the possible causative factors associated with medication wastage and the effectiveness of any interventions to reduce wastage. Method A systematic review of studies published in English was identified from the following databases: Cumulative Index to Nursing and Allied Health Literature, Embase, Medline, PubMed, Science Citation Index and The Cochrane Library. Data extraction and critical appraisal was undertaken independently by two researchers. Results and discussion Title, abstract and full paper screening reduced the 14,157 studies to 42. A general definition of medication wastage was reported in one paper only. 'Medication changed', 'patient death', 'resolution of patient's condition' and 'expired medications' were most commonly cited reasons for wastage. Only two studies were identified reporting wastage as a research outcome measure following intervention. Conclusion The systematic review has identified a limited literature on medication wastage with a lack of consistency of terms. There is a paucity of robust research focusing on the impact of healthcare interventions on outcomes around medication wastage. PMID:25037952

West, Lorna Marie; Diack, Lesley; Cordina, Maria; Stewart, Derek

2014-10-01

391

Complementary Psychosocial Interventions in Child and Adolescent Psychiatry: Pet Assisted Therapy  

PubMed Central

Pet assisted therapy (PAT) is a form of complementary psychosocial intervention used in the field of mental health and disability. The form of therapy has the potential to augment the other forms of psychotherapies and pharmacotherapy. This article is an overview of history and clinical origins of PAT, classification and therapy models, scientific basis, the current use in specific disorders, preventive and diagnostic role as well as the potential risks among children and adolescents with mental health needs with a special focus on the Indian needs. A systematic electronic search strategy was undertaken to identify the intervention effectiveness of PAT in MedLine (PubMed), cochrane database of systematic reviews, high-wire press and Google Scholar. We augmented our electronic search with a search of additional articles in reference lists of retrieved articles, as well as a hand search available journals that were not indexed in any electronic database in consultation with colleagues and experts. To qualify for inclusion, studies were required to meet predetermined criteria regarding study design, study population, interventions evaluated and outcome measured to reduce the publication bias. PMID:24701004

Chandramouleeswaran, Susmita; Russell, Paul Swamidhas Sudhakar

2014-01-01

392

Nouvelle approche ? la prise en charge des condylomes  

PubMed Central

Résumé Objectif Faire le résumé des anciens et des nouveaux moyens de traitement des verrues génitales ou condylomes et déterminer comment les utiliser de manière appropriée. Sources des données Une recherche documentaire a été effectuée dans les bases de données suivantes: MEDLINE, PubMed, EMBASE, base de données des synthèses systématiques et registre central des études contrôlées de la Collaboration Cochrane (en anglais), ACP Journal Club et Trip. Les bibliographies des articles extraits ont aussi été examinées. Les études cliniques, les articles de révision qualitative, les rapports consensuels et les guides de pratique clinique ont été retenus. Message principal Les verrues symptomatiques sont présentes chez au moins 1 % des personnes âgées entre 15 et 49 ans et on estime que jusqu’à 50 % des gens sont infectés par le virus du papillome humain à un moment donné de leur vie. L’imiquimod et la podophyllotoxine sont 2 nouveaux traitements pour les verrues génitales externes qui sont moins douloureux et peuvent être appliqués par les patients à la maison. De plus, il a été démontré que le vaccin quadrivalent contre le virus du papillome humain est efficace pour prévenir les condylomes et le cancer du col. Les plus anciennes méthodes thérapeutiques ont aussi leur place dans certaines situations, comme les verrues intravaginales, urétrales, anales ou récalcitrantes ou encore pour les patientes enceintes. Conclusion Les nouveaux traitements des verrues génitales externes peuvent réduire la douleur causée par la thérapie et le nombre de visites au cabinet. Les autres méthodes thérapeutiques demeurent utiles dans certaines situations.

Lopaschuk, Catharine C.

2013-01-01

393

Heart rate variability in children with type 1 diabetes mellitus  

PubMed Central

OBJECTIVE: To gather current information about the effects of type 1 diabetes mellitus on children's cardiac autonomic behavior. DATA SOURCES: The search of articles was conducted on PubMed, Ibecs, Medline, Cochrane, Lilacs, SciELO and PEDro databases using the MeSH terms: "autonomic nervous system", "diabetes mellitus", "child", "type 1 diabetes mellitus", "sympathetic nervous system" and "parasympathetic nervous system", and their respective versions in Portuguese (DeCS). Articles published from January 2003 to February 2013 that enrolled children with 9-12 years old with type 1 diabetes mellitus were included in the review. DATA SYNTHESIS: The electronic search resulted in four articles that approached the heart rate variability in children with type 1 diabetes mellitus, showing that, in general, these children present decreased global heart rate variability and vagal activity. The practice of physical activity promoted benefits for these individuals. CONCLUSIONS: Children with type 1 diabetes mellitus present changes on autonomic modulation, indicating the need for early attention to avoid future complications in this group. PMID:25119762

Gardim, Camila Balsamo; de Oliveira, Bruno Affonso P.; Bernardo, Aline Fernanda B.; Gomes, Rayana Loch; Pacagnelli, Francis Lopes; Lorenconi, Roselene Modolo R.; Vanderlei, Luiz Carlos M.

2014-01-01

394

Potential role of melatonin in prevention and treatment of oral carcinoma  

PubMed Central

Melatonin, a hormone secreted mainly by pineal gland has been found to have antioxidant and anti-inflammatory properties in the oral cavity where it reaches through saliva. These properties have been found to be beneficial in certain oral pathologies including periodontal diseases, herpes viral infections and Candida, local inflammatory processes, xerostomia, oral ulcers and oral cancer. The objective of this review is to discuss the mechanism of action and potential role of melatonin as a preventive and curative agent for oral cancer. an extensive review of databases like pubmed, medline, science direct and Cochrane reviews was conducted to find articles related to beneficial actions of melatonin in human body with focus on cancers. Numerous studies both in-vitro and in-vivo had shown promising results regarding role of melatonin as anti-carcinogenic agent. Melatonin may play a role in protecting the oral cavity from tissue damage caused by oxidative stress. The experimental evidence suggests that melatonin may have utility in the treatment of several common cancers of the body. However, more specific studies are necessary to extend the therapeutic possibilities to oral carcinoma.

Mehta, Abhishek; Kaur, Gurkiran

2014-01-01

395

Efficacy of ilaprazole in the treatment of duodenal ulcers: A meta-analysis  

PubMed Central

AIM: To compare the efficacy and tolerance of ilaprazole compared with other proton pump inhibitors (PPIs) in the treatment of duodenal ulcer. METHODS: An electronic database search of Medline, Embase, the Cochrane controlled trials register, Web of Science, PubMed, and the Chinese Biomedical Literature Database (updated to July 2013), and manual searches were conducted. A meta-analysis of randomized controlled trials comparing the efficacy and tolerance of ilaprazole and other PPIs in the treatment of duodenal ulcers was performed. RESULTS: Five articles involving 1481 patients were included. The meta-analysis showed no difference in the 4-wk healing rate between ilaprazole and other PPIs [89.7% vs 87.0%; relative risk (RR) = 1.02; 95%CI: 0.98-1.06; Z = 1.00; P = 0.32]. The results did not change in the sensitivity analyses. The meta-analysis indicated that the adverse effect rate in the ilaprazole group was lower than that in the control group, but the difference was not significant (9.7% vs 13.0%; RR = 0.81; 95%CI: 0.60-1.07; Z = 1.47; P = 0.14). CONCLUSION: Ilaprazole is a highly effective and safe PPI in the treatment of duodenal ulcers. Ilaprazole can be recommended as a therapy for acid-related disorders, especially in Asian populations. PMID:24803828

Ji, Xi-Qing; Du, Jun-Feng; Chen, Gang; Chen, Guang; Yu, Bo

2014-01-01

396

Distance learning project--information skills training: supporting flexible trainees in psychiatry.  

PubMed

This one-year project was designed to investigate the skills training needs of a group of 12 specialist registrars in psychiatry working as flexible trainees (part time) in the NHS. They had expressed concerns about their lack of information technology skills at training assessment seminars. A part-time project officer, was appointed to support the group giving information skills training to each flexible trainee on an individual basis, through a series of home visits. The project officer worked under the supervision of the London Library & Information Development Unit (LLIDU) from a home base, to identify with the insular feelings expressed by the project group. Project funding purchased a laptop computer with modem and a printer for each participant to use during the project. The training covered: basic search skills and developing search strategy techniques using quality filters particularly in relation to the MEDLINE database; how to search the Cochrane Library and PubMed and exploiting Internet information resources. The group asked for help with word processing and presentation software use. These needs were met in a series of half-day workshops. Experience and insight gained during the project will feed into future planning of information skills training for larger numbers of flexible trainees. PMID:12389605

Poyner, Ann; Wood, Aileen; Herzberg, Joe

2002-06-01

397

Analgesia for infants' circumcision  

PubMed Central

Male circumcision (MC) is one of the oldest and most common operations performed all over the world. It can be performed at different ages, using different surgical techniques, for different religious, cultural and medical reasons. Our aim is to examine and compare the various methods of analgesia and different surgical procedures reported in literature that are applied in infant MC. We performed a PubMed, MEDLINE, EMBASE and Cochrane search in the papers published since 2000: 14 studies met the inclusion criteria, most of them showing that a combined pharmacological and non-pharmacological intervention is the best analgesic option, in particular when the dorsal penile nerve block is combined with other treatments. The Mogen surgical procedure seems to be the less painful surgical intervention, when compared with Gomco clamp or PlastiBell device. Only 3 papers studied groups of at least 20 babies each with the use of validated pain scales. Data show a dramatic decrease of pain with dorsal penile nerve block, plus acetaminophen associated to oral sucrose or topic analgesic cream. However, no procedure has been found to definetively eliminate pain; the gold standard procedure to make MC totally painfree has not yet been established. PMID:23759130

2013-01-01

398

Public health interventions in midwifery: a systematic review of systematic reviews  

PubMed Central

Background Maternity care providers, particularly midwives, have a window of opportunity to influence pregnant women about positive health choices. This aim of this paper is to identify evidence of effective public health interventions from good quality systematic reviews that could be conducted by midwives. Methods Relevant databases including MEDLINE, Pubmed, EBSCO, CRD, MIDIRS, Web of Science, The Cochrane Library and Econlit were searched to identify systematic reviews in October 2010. Quality assessment of all reviews was conducted. Results Thirty-six good quality systematic reviews were identified which reported on effective interventions. The reviews were conducted on a diverse range of interventions across the reproductive continuum and were categorised under: screening; supplementation; support; education; mental health; birthing environment; clinical care in labour and breast feeding. The scope and strength of the review findings are discussed in relation to current practice. A logic model was developed to provide an overarching framework of midwifery public health roles to inform research policy and practice. Conclusions This review provides a broad scope of high quality systematic review evidence and definitively highlights the challenge of knowledge transfer from research into practice. The review also identified gaps in knowledge around the impact of core midwifery practice on public health outcomes and the value of this contribution. This review provides evidence for researchers and funders as to the gaps in current knowledge and should be used to inform the strategic direction of the role of midwifery in public health in policy and practice. PMID:23134701

2012-01-01

399

Interactions among Low Dose of Methotrexate and Drugs Used in the Treatment of Rheumatoid Arthritis  

PubMed Central

Methotrexate (MTX) is a nonbiological disease-modifying antirheumatic drug that has shown both a good control of clinical disease and a good safety. Usually drug-drug interactions (DDIs) represent the most limiting factor during the clinical management of any disease, in particular when several drugs are coadministered to treat the same disease. In this paper, we report the interactions among MTX and the other drugs commonly used in the management of rheumatoid arthritis. Using Medline, PubMed, Embase, Cochrane libraries, and Reference lists, we searched for the articles published until June 30, 2012, and we reported the most common DDIs between MTX and antirheumatic drugs. In particular, clinically relevant DDIs have been described during the treatment with MTX and NSAIDs, for example, diclofenac, indomethacin, or COX-2 inhibitors, and between MTX and prednisone or immunosuppressant drugs (e.g., leflunomide and cyclosporine). Finally, an increase in the risk of infections has been recorded during the combination treatment with MTX plus antitumor necrosis factor-? agents. In conclusion, during the treatment with MTX, DDIs play an important role in both the development of ADRs and therapeutic failure. PMID:23737767

Patane, Marinella; Ciriaco, Miriam; Chimirri, Serafina; Ursini, Francesco; Naty, Saverio; Grembiale, Rosa Daniela; Gallelli, Luca; De Sarro, Giovambattista

2013-01-01

400

Management of recurrent vault prolapse.  

PubMed

In the ageing female population, recurrent vaginal vault prolapse is a significant healthcare burden. There is limited evidence regarding the optimal management strategy for recurrent vault prolapse. This paper aims to discuss treatment modalities available for recurrent vault prolapse. A literature search and analysis was performed using Medline, PubMed, Cochrane database, current texts and references from relevant articles. We found inconclusive evidence supporting conservative, mechanical and some surgical options for treating recurrent vault prolapse; including iliococcygeal fixation, McCall culdoplasty, and infracoccygeal sacropexy. Sacrospinous ligament fixation (SSLF), sacrocolpopexy, mesh implants and colpocleisis are shown to have good outcomes in Level II studies. Nevertheless, the first two are associated with haemorrhage, dyspareunia and scarring whilst colpocleisis is limited to selected patients. More well-designed studies are required for recurrent vault prolapse. Current evidence suggests SSLF, and sacrocolpopexy are alternative surgical options to colpocleisis in treating recurrent vault prolapse. Randomised trials are required to determine the efficacy and safety of trocar-guided mesh kits. PMID:21725676

Toh, V V; Bogne, V; Bako, A

2012-01-01

401

Manual therapies for primary chronic headaches: a systematic review of randomized controlled trials.  

PubMed

This is to our knowledge the first systematic review regarding the efficacy of manual therapy randomized clinical trials (RCT) for primary chronic headaches. A comprehensive English literature search on CINHAL, Cochrane, Medline, Ovid and PubMed identified 6 RCTs all investigating chronic tension-type headache (CTTH). One study applied massage therapy and five studies applied physiotherapy. Four studies were considered to be of good methodological quality by the PEDro scale. All studies were pragmatic or used no treatment as a control group, and only two studies avoided co-intervention, which may lead to possible bias and makes interpretation of the results more difficult. The RCTs suggest that massage and physiotherapy are effective treatment options in the management of CTTH. One of the RCTs showed that physiotherapy reduced headache frequency and intensity statistical significant better than usual care by the general practitioner. The efficacy of physiotherapy at post-treatment and at 6 months follow-up equals the efficacy of tricyclic antidepressants. Effect size of physiotherapy was up to 0.62. Future manual therapy RCTs are requested addressing the efficacy in chronic migraine with and without medication overuse. Future RCTs on headache should adhere to the International Headache Society's guidelines for clinical trials, i.e., frequency as primary end-point, while duration and intensity should be secondary end-point, avoid co-intervention, includes sufficient sample size and follow-up period for at least 6 months. PMID:25278005

Chaibi, Aleksander; Russell, Michael Bjørn

2014-01-01

402

Assessing the mental health consequences of military combat in Iraq and Afghanistan: a literature review.  

PubMed

The aim of this paper was to explore how a military career may affect the mental health of serving and ex-service personnel, to identify the accessibility and helpfulness of support (both during and after military service) and to make recommendations for change. A literature search was undertaken using the MetaFind meta search engine with keywords: mental health, psychological health, emotional health, soldier, British army, army, ex-army, military, military personnel, armed forces, resettlement, impact, family relationship, divorce, health, support services. The search was applied to the following databases: EBSCO Host, CINAHL, Cochrane Library, Ingenta Connect, Medline, PsyArticles, PubMed, Web of Knowledge, together with the specific journals American Journal of Psychiatry, British Journal of Psychiatry and ProQuest Nursing journals. 110 relevant publications were identified and from these 61 papers were retrieved for further analysis. Poor mental health is associated with increased risk of social exclusion on leaving the services, which further exacerbates mental health problems. An increasing number of ex-service personnel are expected to develop stress-related mental health problems in the future. PMID:21040224

Walker, S

2010-11-01

403

Two Polymorphisms in the Fractalkine Receptor CX3CR1 Gene Influence the Development of Atherosclerosis: A Meta-Analysis  

PubMed Central

Background. The associations between the Fractalkine receptor (CX3CR1) gene T280M (rs3732378) and V249I (rs3732379) polymorphisms and atherosclerosis (AS) risk are conflicting. The aim of this meta-analysis was undertaken to assess their associations. Methods. PubMed, Embase, Web of Science, Medline, Cochrane database, and CNKI were searched to get the genetic association studies. All statistical analyses were done with Stata 11.0. Results. Twenty-five articles involving 49 studies were included in the final meta-analysis. The analysis showed that the 280M allele carriers of the CX3CR1 T280M polymorphism decreased the risk of AS and coronary artery disease (CAD) in the heterozygous state but increased the risk of ischemic cerebrovascular disease (ICVD) in the homozygote state. The 249I allele carriers of the CX3CR1 V249I polymorphism decreased the risk of AS and CAD in the heterozygous state. The V249I-T280M combined genotype VITM and IITM also decreased the risk of AS. Conclusions. The present meta-analysis suggests that the CX3CR1 T280M and V249I polymorphisms are associated with the susceptibility to AS. However, the results should be interpreted with caution because of the high heterogeneity in the meta-analysis.

Wu, Jian; Yin, Rui-Xing; Lin, Quan-Zhen; Shi, Guang-Yuan; Sun, Jia-Qi; Shen, Shao-Wen; Li, Qing

2014-01-01

404

Decompressive craniectomy for the treatment of malignant infarction of the middle cerebral artery.  

PubMed

Early decompressive craniectomy (DC) has been shown to reduce mortality in malignant middle cerebral artery (MCA) infarction, whereas efficacy of DC on functional outcome is inconclusive. Here, we performed a meta-analysis to estimate the effects of DC on malignant MCA infarction and investigated whether age of patients and timing of surgery influenced the efficacy. We systematically searched PubMed, Medline, Embase, Cochrane library, Web of Science update to June 2014. Finally, A total of 14 studies involved 747 patients were included, of which 8 were RCTs (341 patients). The results demonstrated that early DC (within 48?h after stroke onset) decreased mortality (OR = 0.14, 95%CI = 0.08, 0.25, p<0.0001) and number of patients with poor functional outcome (modified Rankin scale (mRS)>3) (OR = 0.38, 95%CI = 0.20, 0.73, p = 0.004) for 12 months follow-up. In the subgroup analysis stratified by age, early DC improved outcome both in younger and older patients. However, later DC (after 48h after stroke onset) might not have a benefit effect on lowering mortality or improving outcome in patients with malignant infarction. Together, this study suggested that decompressive surgery undertaken within 48?h reduced mortality and increased the number of patients with a favourable outcome in patients with malignant MCA infarction. PMID:25400113

Lu, XiaoCheng; Huang, BaoSheng; Zheng, JinYu; Tao, Yi; Yu, Wan; Tang, LinJun; Zhu, RongLan; Li, Shuai; Li, LiXin

2014-01-01

405

Adjunctive rifampicin may improve outcomes in Staphylococcus aureus bacteraemia: a systematic review.  

PubMed

Staphylococcus aureus bacteraemia (SAB) is associated with substantial morbidity and mortality. By surviving within leukocytes, S. aureus can evade both immunological defences and antimicrobial drugs, thus facilitating haematogenous dissemination. We performed a systematic review to determine whether antimicrobials with intracellular activity improve outcomes in SAB when used as an adjunct to ?-lactam or glycopeptide monotherapy. The Pubmed/MEDLINE, Embase and Cochrane databases were systematically searched for eligible studies that reported on the use of first-line antimicrobials plus a single additional antimicrobial of interest in patients with SAB (any cause). Six relevant studies were identified, all reporting on rifampicin use. Four studies (three randomized controlled trials and one cohort) reported on adults with SAB, including 54 patients treated with adjunctive rifampicin and 44 standard-therapy controls. Estimated across all of these studies, adjunctive rifampicin was associated with trends towards reduced all-cause mortality and reduced clinical or bacteriological failure. The fifth study indicated that adjunctive rifampicin accelerates the resolution of persistent SAB in neonates. Data from the sixth study were considered flawed owing to differences in co-morbidities between groups. Limited data suggest that rifampicin-induced hepatitis is not clinically significant but that drug interactions are. In conclusion, adjunctive rifampicin may improve outcomes in SAB when used as an adjunct to ?-lactam or glycopeptide monotherapy. PMID:24623637

Russell, Clark D; Lawson McLean, Aaron; Saunders, Christopher; Laurenson, Ian F

2014-06-01

406

Enigma of urethral pain syndrome: why are there so many ascribed etiologies and therapeutic approaches?  

PubMed

Urethral pain syndrome has had several sobriquets, which have led to much confusion over the existence of this pathological condition and the useful options in the care of the afflicted patient. Our aim was to explore the proposed etiologies of this syndrome, and to provide a critical analysis of each proposed etiology and present a balanced argument on the plausibility of the proposed etiology and therapeutic approaches. We carried out an English language electronic search in the following databases: Medline, Embase, Amed, Cinahl, Pubmed, Cochrane Library, Trip Database and SUMSearch using the following search terms: urethral syndrome, urethral diseases, urethra, urologic diseases etiology/etiology, presentation, treatment, outcome, therapeutics and treatment from 1951 to 2011. In excess of 200 articles were recovered. With the clearly defined objectives of analyzing the proposed etiologies and therapeutic regimes, two author(s) (HP and IO) perused the abstracts of all the recovered articles, selecting those that addressed the etiologies and therapeutic approaches to treating the urethral pain syndrome. The number of articles was reduced to 25. The full text of all 25 articles were retrieved and reviewed. Through the present article, we hope to elucidate the most probable etiology of this condition whilst simultaneously, advance a logical explanation for the apparent success in the treatment of this condition using a range of different therapeutic modalities. We have carried out a narrative review, which we hope will reduce some of the confusion around this clinical entity by combining the known facts about the disease. PMID:24447292

Phillip, Harris; Okewole, Idris; Chilaka, Victor

2014-06-01

407

Relative efficacy and safety of direct oral anticoagulants in patients with atrial fibrillation by network meta-analysis  

PubMed Central

Background Much direct evidence has proved that the novel oral anticoagulants (NOACs) are noninferior or superior to warfarin for stroke prevention in patients with nonvalvular atrial fibrillation, and lead to a relevant decrease in bleeding profiles. However, no study has compared NOACs with each other head-to-head. The current study is a network meta-analysis aiming to assess the efficacy and safety of NOACs. Methods Cochrane library, Pubmed NCBI, EMBASE and MEDLINE were systematically searched for randomized controlled trials that assessed the efficacy and safety profiles of NOACs compared with warfarin. The primary outcome was the rate of stroke or systemic embolism, and the secondary outcome was the rate of bleeding events. Network meta-analysis was performed using Markov chain Monte Carlo methods. Results A total of four phase III randomized controlled trials (n?=?71683) met the inclusion criteria. All NOACs except low dose of edoxaban showed noninferior efficacies to warfarin in stroke prevention. In the field of hemorrhage, apixaban was safer than edoxaban 60?mg in any bleeding events and had fewer major bleeding events compared with dabigatran 150?mg and rivaroxaban. Conclusion NOACs are promising candidates for stroke prevention in patients with nonvalvular atrial fibrillation due to a favorable risk–benefit profile. All NOACs other than edoxaban 30?mg had parallel efficacies with respect to stroke prevention. Apixaban had an advantage over the other NOACs in safety. PMID:25304034

Fu, Wenbin; Guo, Hongyang; Guo, Jianping; Lin, Kun; Wang, Haijun; Zhang, Yu; Wang, Yutang; Shan, Zhaoliang

2014-01-01

408

Decompressive craniectomy for the treatment of malignant infarction of the middle cerebral artery  

PubMed Central

Early decompressive craniectomy (DC) has been shown to reduce mortality in malignant middle cerebral artery (MCA) infarction, whereas efficacy of DC on functional outcome is inconclusive. Here, we performed a meta-analysis to estimate the effects of DC on malignant MCA infarction and investigated whether age of patients and timing of surgery influenced the efficacy. We systematically searched PubMed, Medline, Embase, Cochrane library, Web of Science update to June 2014. Finally, A total of 14 studies involved 747 patients were included, of which 8 were RCTs (341 patients). The results demonstrated that early DC (within 48?h after stroke onset) decreased mortality (OR = 0.14, 95%CI = 0.08, 0.25, p<0.0001) and number of patients with poor functional outcome (modified Rankin scale (mRS)>3) (OR = 0.38, 95%CI = 0.20, 0.73, p = 0.004) for 12 months follow-up. In the subgroup analysis stratified by age, early DC improved outcome both in younger and older patients. However, later DC (after 48h after stroke onset) might not have a benefit effect on lowering mortality or improving outcome in patients with malignant infarction. Together, this study suggested that decompressive surgery undertaken within 48?h reduced mortality and increased the number of patients with a favourable outcome in patients with malignant MCA infarction. PMID:25400113

Lu, XiaoCheng; Huang, BaoSheng; Zheng, JinYu; Tao, Yi; Yu, Wan; Tang, LinJun; Zhu, RongLan; Li, Shuai; Li, LiXin

2014-01-01

409

Consensus methods: review of original methods and their main alternatives used in public health  

PubMed Central

Summary Background Consensus-based studies are increasingly used as decision-making methods, for they have lower production cost than other methods (observation, experimentation, modelling) and provide results more rapidly. The objective of this paper is to describe the principles and methods of the four main methods, Delphi, nominal group, consensus development conference and RAND/UCLA, their use as it appears in peer-reviewed publications and validation studies published in the healthcare literature. Methods A bibliographic search was performed in Pubmed/MEDLINE, Banque de Données Santé Publique (BDSP), The Cochrane Library, Pascal and Francis. Keywords, headings and qualifiers corresponding to a list of terms and expressions related to the consensus methods were searched in the thesauri, and used in the literature search. A search with the same terms and expressions was performed on Internet using the website Google Scholar. Results All methods, precisely described in the literature, are based on common basic principles such as definition of subject, selection of experts, and direct or remote interaction processes. They sometimes use quantitative assessment for ranking items. Numerous variants of these methods have been described. Few validation studies have been implemented. Not implementing these basic principles and failing to describe the methods used to reach the consensus were both frequent reasons contributing to raise suspicion regarding the validity of consensus methods. Conclusion When it is applied to a new domain with important consequences in terms of decision making, a consensus method should be first validated. PMID:19013039

Bourrée, Fanny; Michel, Philippe; Salmi, Louis Rachid

2008-01-01

410

Utility of electrocorticography in the surgical treatment of cavernomas presenting with pharmacoresistant epilepsy.  

PubMed

Aim. To describe the general aspects of cavernomas and epilepsy and review the available literature on the utility of electrocorticography (ECoG) in cerebral cavernoma surgery. Methods. We searched studies in PubMed, MedLine, Scopus, Web of Science, and Google Scholar (from January 1969 to December 2013) using the keywords "electrocorticography" or "ECoG" or "prognosis" or "outcome" and "cavernomas". Original articles that reported utility of ECoG in epilepsy surgery were included. Four review authors independently selected the studies, extracted data, and assessed the methodological quality of the studies using the recommendations of the Cochrane Handbook for Systematic Reviews of Interventions, PRISMA guidelines, and Jadad Scale. A meta-analysis was not possible due to methodological, clinical, and statistical heterogeneity of included studies. We analysed six articles with a total of 219 patients. Results. The most common surgical approach was lesionectomy using ECoG in the temporal lobe with Engel I outcome range from 72.7 to 100%. Conclusions. Small controlled studies suggest that ECoG-guided resection offers the best functional results in seizure control for subjects undergoing cavernoma surgery, especially in the temporal lobe. PMID:25204009

San-Juan, Daniel; Díaz-Nuñez, Iván Cesár; Ojeda-Baldéz, Mónica; Barajas-Juárez, Víctor Armando; González-Hernández, Iliana; Alonso-Vanegas, Mario; Anschel, David J; Delgado de la Mora, Jesús; Davila-Avila, Ned Merari; Romero-Gameros, Carlos Alfonso; Vázquez-Gregorio, Rafael; Hernández-Ruíz, Axel

2014-09-01

411

Complications following volar locking plate fixation for distal radial fractures: a systematic review.  

PubMed

The purpose of this systematic review is to assess the prevalence of complications following volar locking plate fixation of distal radial fractures. A computer-based search was carried out using EMBASE and PUBMED/MEDLINE. Only prospective comparative and prospective cohort studies that presented data concerning complications after treatment of distal radial fractures with a volar locking plate in human adults with a minimal follow-up of 6 months were included. Two quality assessment tools were used to assess the methodological quality of the studies (level of evidence rating according to the Oxford Centre of Evidence Based Medicine and the modified version of the Cochrane Bone, Joint and Muscle Trauma Group's former quality assessment tool). Thirty three studies were eligible for final assessment. Most complications were problems with nerve and tendon function as well as complex regional pain syndrome. With an overall complication rate of 16.5%, most of which were 'minor' complications and low rates of nonunion and malunion, volar locking plate fixation can be considered a reasonably safe treatment option for patients with distal radial fractures. PMID:24262583

Bentohami, A; de Burlet, K; de Korte, N; van den Bekerom, M P J; Goslings, J C; Schep, N W L

2014-09-01

412

Manual therapies for primary chronic headaches: a systematic review of randomized controlled trials  

PubMed Central

This is to our knowledge the first systematic review regarding the efficacy of manual therapy randomized clinical trials (RCT) for primary chronic headaches. A comprehensive English literature search on CINHAL, Cochrane, Medline, Ovid and PubMed identified 6 RCTs all investigating chronic tension-type headache (CTTH). One study applied massage therapy and five studies applied physiotherapy. Four studies were considered to be of good methodological quality by the PEDro scale. All studies were pragmatic or used no treatment as a control group, and only two studies avoided co-intervention, which may lead to possible bias and makes interpretation of the results more difficult. The RCTs suggest that massage and physiotherapy are effective treatment options in the management of CTTH. One of the RCTs showed that physiotherapy reduced headache frequency and intensity statistical significant better than usual care by the general practitioner. The efficacy of physiotherapy at post-treatment and at 6 months follow-up equals the efficacy of tricyclic antidepressants. Effect size of physiotherapy was up to 0.62. Future manual therapy RCTs are requested addressing the efficacy in chronic migraine with and without medication overuse. Future RCTs on headache should adhere to the International Headache Society’s guidelines for clinical trials, i.e. frequency as primary end-point, while duration and intensity should be secondary end-point, avoid co-intervention, includes sufficient sample size and follow-up period for at least 6 months. PMID:25278005

2014-01-01

413

Epinephrine in out-of-hospital cardiac arrest: A critical review  

PubMed Central

BACKGROUND: Epinephrine is recommended in advanced cardiac life support guidelines for use in adult cardiac arrest, and has been used in cardiopulmonary resuscitation since 1896. Yet, despite its long time use and incorporation into guidelines, epinephrine suffers from a paucity of evidence regarding its influence on survival. This critical review was conducted to address the knowledge deficit regarding epinephrine in out-of-hospital cardiac arrest and its effect on return of spontaneous circulation, survival to hospital discharge, and neurological performance. METHODS: The EMBASE and MEDLINE (through the Pubmed interface) databases, and the Cochrane library were searched with the key words “epinephrine”, “cardiac arrest” and variations of these terms. Original research studies concerning epinephrine use in adult, out-of-hospital cardiac arrest were selected for further review. RESULTS: The search yielded nine eligible studies based on inclusion criteria. This includes five prospective cohort studies, one retrospective cohort study, one survival analysis, one case control study, and one RCT. The evidence clearly establishes an association between epinephrine and increased return of spontaneous circulation, the data were conflicting concerning survival to hospital discharge and neurological outcome. CONCLUSIONS: The results of this review exhibit the paucity of evidence regarding the use of epinephrine in out of hospital cardiac arrest. There is currently insufficient evidence to support or reject its administration during resuscitation. Larger sample, placebo controlled, double blind, randomized control trials need to be performed to definitively establish the effect of epinephrine on both survival to hospital discharge and the neurological outcomes of treated patients. PMID:25215099

Reardon, Peter M.; Magee, Kirk

2013-01-01

414

Health care quality improvement publication trends.  

PubMed

To analyze the extent of academic interest in quality improvement (QI) initiatives in medical practice, annual publication trends for the most well-known QI methodologies being used in health care settings were analyzed. A total of 10 key medical- and business-oriented library databases were examined: PubMed, Ovid MEDLINE, EMBASE, CINAHL, PsycINFO, ISI Web of Science, Scopus, the Cochrane Central Register of Controlled Trials, ABI/INFORM, and Business Source Complete. A total of 13 057 articles were identified that discuss at least 1 of 10 well-known QI concepts used in health care contexts, 8645 (66.2%) of which were classified as original research. "Total quality management" was the only methodology to demonstrate a significant decline in publication over time. "Continuous quality improvement" was the most common topic of study across all publication years, whereas articles discussing Lean methodology demonstrated the largest growth in publication volume over the past 2 decades. Health care QI publication volume increased substantially beginning in 1991. PMID:24101680

Sun, Gordon H; MacEachern, Mark P; Perla, Rocco J; Gaines, Jean M; Davis, Matthew M; Shrank, William H

2014-01-01

415

Oral Oncoprevention by Phytochemicals - A Systematic Review Disclosing the Therapeutic Dilemma  

PubMed Central

The aim of this article is to emphasize and focus on the preclinical and clinical update on phytochemicals and their role in prevention of oral carcinogenesis. Accordingly, the literature search was made following database: Embase, Medline, Science Citation index, NIH public access, pubmed and Cochrane Database of systematic reviews. Several internet websites were also searched to access publications from major phytochemical research sites and relevant information was obtained with regards to each plant chemical. The authors also spotted different list servers through wignet.com, Stanford cancer research etc: The data base search was made from the inception to 1988 and updated till 2013. A systematic method was obtained for literature search and data collection was critiqued. 60 articles were searched, among which there were only 6 systematic reviews on phytochemicals regarding oral carcinogenesis. Additional articles were obtained on phytochemicals and their mechanism of action in other cancers, which were regarded as background material. The studies done by various authors on each phytochemical has been briefly emphasized. PMID:25364656

Bhavana, Sujana Mulk; Lakshmi, Chintamaneni Raja

2014-01-01

416

Adjuvant interferon for early or late recurrence of hepatocellular carcinoma and mortality from hepatocellular carcinoma following curative treatment: A meta-analysis with comparison of different types of hepatitis  

PubMed Central

Adjuvant interferon (IFN) therapy following curative treatment for hepatocellular carcinoma (HCC) has been extensively investigated; however, the clinical benefits with different hepatitis backgrounds remain unclear. Medline, Embase, PubMed and the Cochrane Library databases were searched to identify randomized trials and cohort studies that enrolled HCC patients who received curative surgery or ablation therapy followed by IFN and control subjects; the studies were required to include data on early or late recurrence and mortality rates of HCC. Hepatitis B virus (HBV) associated with HCC (HBV-HCC) and hepatitis C virus (HCV) associated with HCC (HCV-HCC) were separately analyzed and recurrence, mortality and clinicopathological factors were compared. A total of 14 studies (9 randomized trials and 5 cohort studies, including 1,385 patients in total) were eligible for meta-analysis. IFN was found to decrease mortality and early recurrence rates, but exerted no effect on late recurrence rate. The effect of IFN differed between HBV-HCC and HCV-HCC cases. In HCV-HCC, IFN significantly reduced mortality as well as recurrence rates. However, in HBV-HCC patients, IFN reduced mortality rather than recurrence rates, although it also reduced the recurrence rate in certain subgroups. In conclusion, the effect of adjuvant IFN on postoperative recurrence differed between HBV-HCC and HCV-HCC cases; therefore, different strategies with adjuvant IFN should be used to treat HCC with different hepatitis backgrounds.

ZHANG, WEI; SONG, TIAN-QIANG; ZHANG, TI; WU, QIANG; KONG, DA-LU; LI, QIANG; SUN, HUI-CHUAN

2014-01-01

417

A systematic review of lateral wedge orthotics--how useful are they in the management of medial compartment osteoarthritis?  

PubMed

Studies on the use of lateral wedge orthotics in the conservative management of medial compartment osteoarthritis are widely quoted. This approach, however, does not consider the disruption of the interaction between lower limb and foot and ankle function that lateral wedges would produce. This comprehensive, systematic review was therefore undertaken to evaluate all available literature to determine whether evidence exists to support their use. MEDLINE, EMBASE, CINAHL, Allied and Complimentary Medicine, PubMed, EBSCO HOST and PEDro, Abstracts of Reviews of Effects in the National Electronic Library for Health for Cochrane Reviews and manual searching were used to identify studies. was searched for trials in progress. Data extraction was performed by the three authors using a paper data extraction form which was based on the CONSORT statement and Critical Skills Appraisal Programme (CASP) guidelines. Overall, the results of this review suggest that, based on current evidence there are no major or long-term beneficial effects with the use of lateral wedges. PMID:16632366

Reilly, K A; Barker, K L; Shamley, D

2006-06-01

418

A review of web based interventions for managing tobacco use.  

PubMed

Web based interventions (WBIs) have been developed for various health conditions. These include interventions for various psychoactive substance use disorders including tobacco and alcohol. Tobacco use has remained the single largest preventable cause of global mortality and morbidity for many years. It is responsible for around 6 million deaths annually world-wide. Ironically, most of the tobacco users reside in resource poor low and middle-income countries. The article reviews the existing literature on WBIs for management of tobacco use. The literature search was performed using MedLine, PubMed, PsycINFO, Embase and Cochrane Review for relevant English language articles published from 1998 up to 2013. There is limited support for effectiveness of WBIs for managing tobacco use among adolescents. Although most of the trials among adults found WBIs to be more effective at short term follow-up (a few days to weeks), the benefits failed to extend beyond 3 months in most of the studies. All but one interventions studied in a randomized controlled trial is for smoking forms. PMID:25035543

Balhara, Yatan Pal Singh; Verma, Rohit

2014-07-01

419

Continuous Positive Airway Pressure Reduces Risk of Motor Vehicle Crash among Drivers with Obstructive Sleep Apnea: Systematic Review and Meta-analysis  

PubMed Central

Context: Obstructive sleep apnea (OSA) is associated with an increased risk of motor vehicle crash. Objective: We performed a systematic review of the literature concerning the impact of continuous positive airway pressure (CPAP) treatment on motor vehicle crash risk among drivers with OSA. The primary objective was to determine whether CPAP use could reduce the risk of motor vehicle crash among drivers with OSA. A secondary objective involved determining the time on treatment required for CPAP to improve driver safety. Data Sources: We searched seven electronic databases (MEDLINE, PubMed (PreMEDLINE), EMBASE, PsycINFO, CINAHL, TRIS, and the Cochrane library) and the reference lists of all obtained articles. Study Selection: We included studies (before-after, case-control, or cohort) that addressed the stated objectives. We evaluated the quality of each study and the interplay between the quality, quantity, robustness, and consistency of the evidence. We also tested for publication bias. Data Extraction: Data were extracted by two independent analysts. When appropriate, data were combined in a fixed or random effects meta-analysis. Results: A meta-analysis of 9 observational studies examining crash risk of drivers with OSA pre- vs. post-CPAP found a significant risk reduction following treatment (risk ratio = 0.278, 95% CI: 0.22 to 0.35; P < 0.001). Although crash data are not available to assess the time course of change, daytime sleepiness improves significantly following a single night of treatment, and simulated driving performance improves significantly within 2 to 7 days of CPAP treatment. Conclusions: Observational studies indicate that CPAP reduces motor vehicle crash risk among drivers with OSA. Citation: Tregear S; Reston J; Schoelles K; Phillips B. Continuous positive airway pressure reduces risk of motor vehicle crash among drivers with obstructive sleep apnea. SLEEP 2010;33(10):1373-1380. PMID:21061860

Tregear, Stephen; Reston, James; Schoelles, Karen; Phillips, Barbara

2010-01-01

420

Obstructive Sleep Apnea and Risk of Motor Vehicle Crash: Systematic Review and Meta-Analysis  

PubMed Central

Study Objectives: We performed a systematic review of the OSA-related risk of crash in commercial motor vehicle (CMV) drivers. The primary objective involved determining whether individuals with obstructive sleep apnea (OSA) are at an increased risk for a motor vehicle crash when compared to comparable individuals who do not have the disorder. A secondary objective involved determining what factors are associated with an increased motor vehicle crash risk among individuals with OSA. Design/Setting: Seven electronic databases (MEDLINE, PubMed (PreMEDLINE), EMBASE, PsycINFO, CINAHL, TRIS, and the Cochrane library) were searched (through May 27, 2009), as well as the reference lists of all obtained articles. We included controlled studies (case-control or cohort) that evaluated crash risk in individuals with OSA. We evaluated the quality of each study and the interplay between the quality, quantity, robustness, and consistency of the body of evidence, and tested for publication bias. Data were extracted by 2 independent analysts. When appropriate, data from different studies were combined in a fixed- or random-effects meta-analysis. Results: Individuals with OSA are clearly at increased risk for crash. The mean crash-rate ratio associated with OSA is likely to fall within the range of 1.21 to 4.89. Characteristics that may predict crash in drivers with OSA include BMI, apnea plus hypopnea index, oxygen saturation, and possibly daytime sleepiness. Conclusions: Untreated sleep apnea is a significant contributor to motor vehicle crashes. Citation: Tregear S; Reston J; Schoelles K; Phillips B. Obstructive sleep apnea and risk of motor vehicle crash: systematic review and meta-analysis. J Clin Sleep Med 2009;5(6):573-581. PMID:20465027

Tregear, Stephen; Reston, James; Schoelles, Karen; Phillips, Barbara

2009-01-01

421

Small-Sample DIF Estimation Using SIBTEST, Cochran's Z, and Log-Linear Smoothing  

ERIC Educational Resources Information Center

Minimum sample sizes of about 200 to 250 per group are often recommended for differential item functioning (DIF) analyses. However, there are times when sample sizes for one or both groups of interest are smaller than 200 due to practical constraints. This study attempts to examine the performance of Simultaneous Item Bias Test (SIBTEST),…

Lei, Pui-Wa; Li, Hongli

2013-01-01

422

77 FR 17505 - Morris W. Cochran, M.D.: Revocation of Registration  

Federal Register 2010, 2011, 2012, 2013

...show that he ``did not obtain a prior medical history,'' that he ``did not perform...uch prescribing was not for a legitimate medical purpose in the usual course of professional...Therein, the ALJ found that the Alabama Medical Board had not made a recommendation...

2012-03-26

423

Cochrane Lecture 1997. What evidence do we need for evidence based medicine?  

Microsoft Academic Search

As presently understood, evidence based medicine aims to advance practice from its traditional unverifiable mix of art and science to rational use of measurable inputs and outputs. In practice, however, its advocates accept uncritically a desocialised definition of science, assume that major clinical decisions are taken at the level of secondary specialist rather than primary generalist care, and ignore the

J T Hart

1997-01-01

424

Injection therapy for subacute and chronic low back pain: an updated Cochrane review  

Microsoft Academic Search

STUDY DESIGN: A systematic review of randomized controlled trials (RCTs). OBJECTIVE: To determine if injection therapy is more effective than placebo or other treatments for patients with subacute or chronic low back pain. SUMMARY OF BACKGROUND DATA: The effectiveness of injection therapy for low back pain is still debatable. Heterogeneity of target tissue, pharmacological agent, and dosage, generally found in

J Bart Staal; Rob A. de Bie; Henrica C. W. de Vet; Jan Hildebrandt; Patty Nelemans

2009-01-01

425

JAMES J. COCHRAN Bank of Ruston Barnes, Thompson, and Thurmon Endowed  

E-print Network

Associate Professor Department of Marketing & Analysis College of Business & Administration Office: CAB 117A 2006 Founding Chair, IFORS/INFORMS International Education Initiative 2005-Present Faculty Advisor, ASA of the American Statistical Association, 2004 Member, International Statistics Institutes Sports Statistics

Selmic, Sandra

426

Using NEAT to Stabilize an Inverted Pendulum Awjin Ahn and Caleb Cochrane  

E-print Network

with a transfer function, one can design a variety of control systems, such as a PID (proportional, integral of a PID controller is shown in figure 1: Figure 1: A Basic PID Controller. The current system state is fed alternative controller implementations, adaptive control systems have been developed to automatically tune

Meeden, Lisa A.

427

78 FR 62678 - Morris W. Cochran, M.D.; Decision and Order  

Federal Register 2010, 2011, 2012, 2013

...that Respondent violated federal law by: (1) Prescribing methadone to treat substance abuse when he was not registered as a narcotic...program, see 21 U.S.C. 823(g)(1); (2) prescribing methadone to treat substance abuse, see 21 CFR 1306.04(c)...

2013-10-22

428

Nonpharmacological management of procedural pain in infants and young children: An abridged Cochrane review  

PubMed Central

BACKGROUND: Acute pain and distress during medical procedures are commonplace for young children. OBJECTIVE: To assess the efficacy of nonpharmacological interventions for acute procedural pain in children up to three years of age. METHODS: Study inclusion criteria were: participants <3 years of age, involved in a randomized controlled or crossover trial, and use of a ‘no-treatment’ control group (51 studies; n=3396). Additional studies meeting all criteria except for study design (eg, use of active control group) were qualitatively described (n=20). RESULTS: For every intervention, data were analyzed separately according to age group (preterm-born, term-born neonate and older infant/young child) and type of pain response (pain reactivity, immediate pain-related regulation). The largest standardized mean differences (SMD) for pain reactivity were as follows: sucking-related interventions (preterm: ?0.42 [95% CI ?0.68 to ?0.15]; neonate ?1.45 [CI ?2.34 to ?0.57]), kangaroo care (preterm ?1.12 [95% CI ?2.04 to ?0.21]), and swaddling/facilitated tucking (preterm ?0.97 [95% CI ?1.63 to ?0.31]). For immediate pain-related regulation, the largest SMDs were: sucking-related interventions (preterm ?0.38 [95% CI ?0.59 to ?0.17]; neonate ?0.90 [CI ?1.54 to ?0.25]), kangaroo care 0.77 (95% CI ?1.50 to ?0.03]), swaddling/facilitated tucking (preterm ?0.75 [95% CI ?1.14 to ?0.36]), and rocking/holding (neonate ?0.75 [95% CI ?1.20 to ?0.30]). The presence of significant heterogeneity limited confidence in nonsignificant findings for certain other analyses. CONCLUSIONS: Although a number of nonpharmacological treatments have sufficient evidence supporting their efficacy with preterm infants and healthy neonates, no treatments had sufficient evidence to support efficacy with healthy older infants/young children. PMID:22059204

Riddell, Rebecca Pillai; Racine, Nicole; Turcotte, Kara; Uman, Lindsay S; Horton, Rachel; Osmun, Laila Din; Kohut, Sara Ahola; Stuart, Jessica Hillgrove; Stevens, Bonnie; Lisi, Diana

2011-01-01

429

Postoperative Tamoxifen for ductal carcinoma in situ: Cochrane systematic review and meta-analysis.  

PubMed

This review aimed to assess the effects of postoperative Tamoxifen following surgical resection of ductal carcinoma in situ (DCIS). Data on local DCIS recurrence, new invasive carcinoma, distant disease, mortality and adverse effects were extracted from randomised controlled trials (RCTs) comparing Tamoxifen after surgery for DCIS (regardless of oestrogen receptor (ER) status), with or without adjuvant radiotherapy. Meta-analysis was performed using the fixed-effect model and the results expressed as relative risks (RRs) or hazard ratios (HRs) with 95% confidence intervals (CIs). Two RCTs which recruited 3375 women were included. Tamoxifen after surgery for DCIS reduced recurrence of ipsilateral DCIS (HR 0.75; 95% CI 0.61-0.92) and contralateral DCIS (RR 0.50; 95% CI 0.28-0.87). Contralateral invasive cancer was reduced (RR 0.57; 95% CI 0.39-0.83), and there was a trend towards decreased ipsilateral invasive cancer (HR 0.79; 95% CI 0.62-1.01). The number needed to treat in order for Tamoxifen to have a protective effect against all breast events is 15. There was no evidence of a difference in all-cause mortality (RR 1.11; 95% CI 0.89-1.39). Only one trial involving 1799 participants followed-up for 163 months (median) reported on adverse events with no significant difference in event rate between Tamoxifen and placebo groups, but there was a non-significant trend towards more endometrial cancer in the Tamoxifen group. This review concludes that while Tamoxifen after local excision for DCIS, with or without adjuvant radiotherapy, reduced the risk of recurrent DCIS, it did not reduce the risk of all-cause mortality. PMID:25023044

Staley, H; McCallum, I; Bruce, J

2014-10-01

430

Andi M. Cochran Department of Geography and Planning | Appalachian State University  

E-print Network

using Garmin GPS units. Summer 2004 Archaeology Field Technician, Auburn University, Auburn, AL Field archaeologist at Porch-Creek Indian Reservation, duties included phase III excavation, identification of sites, analysis of historic and biological remains, mapping of archaeological site using total station grid system

431

Cochrane Lecture 1997. What evidence do we need for evidence based medicine?  

PubMed Central

As presently understood, evidence based medicine aims to advance practice from its traditional unverifiable mix of art and science to rational use of measurable inputs and outputs. In practice, however, its advocates accept uncritically a desocialised definition of science, assume that major clinical decisions are taken at the level of secondary specialist rather than primary generalist care, and ignore the multiple nature of most clinical problems, as well as the complexity of social problems within which clinical problems arise and have to be solved. These reductionist assumptions derive from the use of evidence based medicine as a tool for managed care in a transactional model for consultations. If these assumptions persist, they will strengthen reification of disease and promote the episodic output of process regardless of health outcome. We need to work within a different paradigm based on development of patients as co-producers rather than consumers, promoting continuing output of health gain through shared decisions using all relevant evidence, within a broader, socialised definition of science. Adoption of this model would require a major social and cultural shift for health professionals. This shift has already begun, promoted by changes in public attitudes to professional authority, changes in the relation of professionals to managers, and pressures for improved effectiveness and efficiency which, contrary to received wisdom, seem more likely to endorse cooperative than transactional clinical production. Progress on these lines is resisted by rapidly growing and extremely powerful economic and political interests. Health professionals and strategists have yet to recognise and admit the existence of this choice. PMID:9519124

Hart, J T

1997-01-01

432

Speech and language therapy for dysarthria due to nonprogressive brain damage: a systematic Cochrane review  

Microsoft Academic Search

Background: Dysarthria is a common sequel of nonprogressive brain damage (typically stroke and traumatic brain damage). Impairment-based therapy and a wide variety of compensatory management strategies are undertaken by speech and language therapists with this patient population.Objective: To determine the efficacy of speech and language therapy interventions for adults with dysarthria following nonprogressive brain damage.Design: Systematic review.Search strategy: This review

Cameron Sellars; Thomas Hughes; Peter Langhorne

2002-01-01

433

Extending the Cochran rule for the comparison of word frequencies between corpora  

E-print Network

of linguistic features in two or more corpora. We then describe the chi-squared and log-likelihood tests used value is 15.13. Keywords: word frequency, chi-squared test, log-likelihood test, corpus linguistics. 1 of the chi- squared and log-likelihood statistics under conditions of different-sized corpora and probability

Rayson, Paul

434

Cannon Cochran Management Services, Inc. (CCMSI) For Office Use Only 100 Quannapowitt Parkway, Suite 201 Claim #  

E-print Network

, or material being used. Be specific. Examples: "climbing a ladder while carrying roofing materials"; "spraying object, substance or motion directly injured you? [Examples: "concrete floor"; "chlorine"; "radial arm"; "chemical burn, right hand"; "carpal tunnel syndrome."] Could this injury result in HIV infection? Yes

Chou, James

435

Relaxation therapies for the management of primary hypertension in adults: a Cochrane review  

Microsoft Academic Search

The objective of this review was to evaluate the effectiveness of relaxation to lower high blood pressure. We searched electronic bibliographic databases and grey literature to identify randomized controlled trials comparing relaxation therapies with no active treatment or sham therapy, enrolling adult participants with raised systolic blood pressure (SBP) ?140 mm Hg or diastolic blood pressure (DBP) ?85 mm Hg

H O Dickinson; F Campbell; F R Beyer; D J Nicolson; J V Cook; G A Ford; J M Mason

2008-01-01

436

Iron deficiency anaemia can be improved after eradication of Helicobacter pylori  

Microsoft Academic Search

BackgroundRecent guidelines on iron deficiency anaemia (IDA) have confirmed the aetiological role of Helicobacter pylori (H pylori), but the relationship still remains controversial.MethodsStarting in May 2009, searches of the following databases were undertaken: Medline (1966 to April 2009), Embase (1980 to April 2009), the Cochrane library (1800 to June 2008), Cochrane Central Register of Controlled Trials, Premedline, Healthstar, CBMdisc and

Xiaolu Huang; Xinhua Qu; Weili Yan; Youliang Huang; Mingci Cai; Bing Hu; Lianming Wu; Hai Lin; Zhiwei Chen; Cuiying Zhu; Lungen Lu; Xu Sun; Lan Rong; Yibin Jiang; Dayu Sun; Liang Zhong; Ping Xiong

2010-01-01

437

Occupational therapy for patients with problems in personal activities of daily living after stroke: systematic review of randomised trials  

Microsoft Academic Search

Objective To determine whether occupational therapy focused specifically on personal activities of daily living improves recovery for patients after stroke.Design Systematic review and meta-analysis.Data sources The Cochrane stroke group trials register, the Cochrane central register of controlled trials, Medline, Embase, CINAHL, PsycLIT, AMED, Wilson Social Sciences Abstracts, Science Citation Index, Social Science Citation, Arts and Humanities Citation Index, Dissertations Abstracts

Lynn Legg; Avril Drummond; Jo Leonardi-Bee; J R F Gladman; Susan Corr; Mireille Donkervoort; Judi Edmans; Louise Gilbertson; Lyn Jongbloed; Pip Logan; Catherine Sackley; Marion Walker; Peter Langhorne

2007-01-01

438

No reliable evidence that ozone gas stops or reverses tooth decay  

Microsoft Academic Search

Data sourcesThe Cochrane Oral Health Group’s Trials Register, Cochrane Central Register of Controlled Trials, Medline and Premedline, Embase, CINAHL (Cumulative Index to nursing and Allied Health Literature)l and the Allied and Complementary Medicine Database were searched. The journal Quintessence was searched by hand and KaVo Dental (Biberach, Germany) manufacturers of HealOzone apparatus were contacted for any additional published or unpublished

Dorothy McComb

2005-01-01

439

Weak, unreliable evidence suggests flossing plus toothbrushing may be associated with a small reduction in plaque  

Microsoft Academic Search

Data sourcesThe Cochrane Oral Health Group Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL) Medline, Embase, CINAHL, LILACS, ZETOC Conference Proceedings, Web of Science Conference Proceedings, Clinicaltrials.gov and the metaRegister of Controlled Clinical Trials databases were searched. Manufacturers of dental floss were also contacted to identify any trials.Study selectionRandomised controlled trials comparing toothbrushing and flossing with only toothbrushing,

Debora Matthews

2012-01-01

440

Mediastinal Lymph Node Dissection versus Mediastinal Lymph Node Sampling for Early Stage Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis  

PubMed Central

Objective This systematic review and meta-analysis aimed to evaluate the overall survival, local recurrence, distant metastasis, and complications of mediastinal lymph node dissection (MLND) versus mediastinal lymph node sampling (MLNS) in stage I–IIIA non-small cell lung cancer (NSCLC) patients. Methods A systematic search of published literature was conducted using the main databases (MEDLINE, PubMed, EMBASE, and Cochrane databases) to identify relevant randomized controlled trials that compared MLND vs. MLNS in NSCLC patients. Methodological quality of included randomized controlled trials was assessed according to the criteria from the Cochrane Handbook for Systematic Review of Interventions (Version 5.1.0). Meta-analysis was performed using The Cochrane Collaboration’s Review Manager 5.3. The results of the meta-analysis were expressed as hazard ratio (HR) or risk ratio (RR), with their corresponding 95% confidence interval (CI). Results We included results reported from six randomized controlled trials, with a total of 1,791 patients included in the primary meta-analysis. Compared to MLNS in NSCLC patients, there was no statistically significant difference in MLND on overall survival (HR?=?0.77, 95% CI 0.55 to 1.08; P?=?0.13). In addition, the results indicated that local recurrence rate (RR?=?0.93, 95% CI 0.68 to 1.28; P?=?0.67), distant metastasis rate (RR?=?0.88, 95% CI 0.74 to 1.04; P?=?0.15), and total complications rate (RR?=?1.10, 95% CI 0.67 to 1.79; P?=?0.72) were similar, no significant difference found between the two groups. Conclusions Results for overall survival, local recurrence rate, and distant metastasis rate were similar between MLND and MLNS in early stage NSCLC patients. There was no evidence that MLND increased complications compared with MLNS. Whether or not MLND is superior to MLNS for stage II–IIIA remains to be determined. PMID:25296033

Huang, Xiongfeng; Wang, Jianmin; Chen, Qiao; Jiang, Jielin

2014-01-01

441

Promoting the uptake of HIV testing among men who have sex with men: systematic review of effectiveness and cost-effectiveness  

Microsoft Academic Search

What interventions are effective and cost-effective in increasing the uptake of HIV testing among men who have sex with men (MSM)? A systematic review was conducted of the following databases: AEGIS, ASSIA, BL Direct, BNI, Centre for Reviews and Dissemination, Cochrane Database of Systematic Reviews, CINAHL, Current Contents Connect, EconLit, EMBASE, ERIC, HMIC, Medline, Medline In-Process, NRR, PsychINFO, Scopus, SIGLE,

Theo Lorenc; Isaac Marrero-Guillamón; Peter Aggleton; Chris Cooper; Alexis Llewellyn; Angela Lehmann; Catriona Lindsay

2011-01-01

442

Using Active Video Games for Physical Activity Promotion: A Systematic Review of the Current State of Research  

ERIC Educational Resources Information Center

This systematic review evaluates interventions using active video games (AVGs) to increase physical activity and summarizes laboratory studies quantifying intensity of AVG play among children and adults. Databases (Cochrane Library, PsychInfo, PubMed, SPORTDiscus, Web of Science) and forward citation and reference list searches were used to…

Peng, Wei; Crouse, Julia C.; Lin, Jih-Hsuan

2013-01-01

443

Physical exercise results in the improved subjective well-being of a few or is effective rehabilitation for all cancer patients?  

Microsoft Academic Search

Physical exercise as an intervention in cancer patients has attracted increasing interest. This review examines the published randomised controlled trials on physical exercise, during and after cancer treatment, focusing primarily on recruitment of patients, patient compliance, content of the intervention programmes and outcome measures. We performed systematic searches of PubMed, PsychInfo, Cancerlit and the Cochrane Library using the MESH terms

L. M. Oldervoll; S. Kaasa; M. J. Hjermstad; J. Å. Lund; J. H. Loge

2004-01-01

444

The relationship between severity of Alzheimer's Disease and the prevalence of comorbid depression: a systematic review  

Microsoft Academic Search

OBJECTIVES: To gain more insight into the association between severity of Alzheimer's Disease (AD) and prevalence of comorbid depression. METHODS: A systematic literature review based on the Cochrane methodology was performed. PubMed, PsychINFO and EMBASE databases were searched for existing studies that fulfilled predefined inclusion criteria. The studies were divided into: (1) those that analysed the association between severity of

R. Verkaik; J. Nuyen; F. G. Schellevis; A. L. Francke

2007-01-01

445

Non-invasive versus invasive respiratory support in preterm infants at birth: systematic review and  

E-print Network

in very preterm infants. Design Systematic review. Data sources PubMed, Embase, the Cochrane Central of death or bronchopulmonary dysplasia, or both, at 36 weeks corrected gestation for babies treated dysplasia for every 25 babies treated with nasal CPAP in the delivery room rather than being intubated

MacMillan, Andrew

446

Benefits and Harms of Sick Leave: Lack of Randomized, Controlled Trials  

ERIC Educational Resources Information Center

The aim of this study was to try to identify those randomized controlled trials that compare sick leave with no sick leave or a different duration or degree of sick leave. A comprehensive, systematic, electronic search of Clinical Evidence, the Cochrane Library and PubMed, and a manual search of the Campbell Library and a journal supplement was…

Axelsson, Inge; Marnetoft, Sven-Uno

2010-01-01

447

The relationship between severity of Alzheimer's disease and prevalence of comorbid depressive symptoms and depression: a systematic review  

Microsoft Academic Search

SUMMARY OBJECTIVES To gain more insight into the association between severity of Alzheimer's Disease (AD) and prevalence of comborbid depression. METHODS A systematic literature review based on the Cochrane methodology was performed. PubMed, PsychINFO and EMBASE databases were searched for existing studies that fulfilled predefined inclusion criteria. The studies were divided into: (1) those that analysed the association between severity

Renate Verkaik; Jasper Nuyen; François Schellevis; Anneke Francke

2007-01-01

448

FNLM Medical Awards | NIH MedlinePlus the Magazine  

MedlinePLUS

... this page please turn Javascript on. FNLM Medical Awards Past Issues / Winter 2012 Table of Contents Dr. ... Oz and Dr. Michael Roizen win health communications award. Four others also honored. T he 2011 FNLM ...

449

Foot Injuries and Disorders - Multiple Languages: MedlinePlus  

MedlinePLUS

... Multiple Languages Arabic (???????) Spanish (español) Arabic (???????) Clubfoot Overview English (Arabic) ????? ??????? ??????? - ??????? Multimedia Patient Education Institute Treating Clubfoot with the Ponseti Method English (Arabic) ???????? ????? ...

450

What is COPD? | NIH MedlinePlus the Magazine  

MedlinePLUS

... please turn JavaScript on. Feature: The Challenge of COPD What is COPD? Fall 2014 Table of Contents COPD is a ... a walk, even washing and dressing. What Is COPD? Watch an animation at: www.nhlbi.nih.gov/ ...

451

What Causes COPD? | NIH MedlinePlus the Magazine  

MedlinePLUS

... please turn JavaScript on. Feature: The Challenge of COPD What Causes COPD? Fall 2014 Table of Contents Long-term exposure ... and the airways usually is the cause of COPD. In the United States, the most common irritant ...

452

MINING MEDLINE: ABSTRACTS, SENTENCES, OR PHRASES? , D. BERLEANTa,d  

E-print Network

, and effectiveness for the task of mining interactions among biochemical terms based on term co- occurrence. Results were shown to be positively regulated by gibberellin (GA) during germination...21 The interactions in this example (gibberellin regulates alpha-Amy2/A and alpha- Amy2/D) are described over two sentences

Wurtele, Eve Syrkin

453

How Is Psoriasis Treated? | NIH MedlinePlus the Magazine  

MedlinePLUS

... skin peel and unclog pores Soothe the skin Light Therapy Natural ultraviolet light from the sun and artificial ultraviolet light are ... psoriasis unless bacteria make the psoriasis worse. Combination ... (put on the skin), light, and systemic treatments, you can often use lower ...

454

From The Director | NIH MedlinePlus the Magazine  

MedlinePLUS

... he grows older. What caused you to start exercising regularly? Like many Americans, I used to eat ... press 135 pounds. Has giving up sweets and exercising regularly helped you? Yes. I feel a lot ...

455

A Pollen Primer | NIH MedlinePlus the Magazine  

MedlinePLUS

... the National Institute of Environmental Health Sciences (NIEHS) . Plant Pollen Ragweed and other weeds, such as curly ... catalpa, elm, hickory, sycamore, and walnut. Protecting yourself Plant species that do not aggravate allergies, such as ...

456

Progress Against Prostate Cancer | NIH MedlinePlus the Magazine  

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... of this page please turn Javascript on. Feature: Prostate Cancer Progress Against Prostate Cancer Past Issues / Winter 2010 Table of Contents Click ... This can narrow the urethra, decreasing urine flow. Prostate cancer is made up of cells the body does ...

457

What's New on MedlinePlus: Announcements and Special Features  

MedlinePLUS

... November 10, 2014 Director's Comments: Health Impacts of Climate Change Listen to the NLM Director's Comments on Health Impacts of Climate Change . The transcript is also available. Climate change may ...

458

2013 Awards Gala Event | NIH MedlinePlus the Magazine  

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... on. Friends of the National Library of Medicine 2013 Awards Gala Event Past Issues / Fall 2013 Table ... Capitol Building Photos courtesy of Michael Spencer, NIH 2013 Awards Gala Event! On September 10, the Friends ...

459

Coping with Disasters - Multiple Languages: MedlinePlus  

MedlinePLUS

... Haitian Creole (Kreyol) Tips for Coping with the Oil Spill Disaster -- Managing Your Stress English Konsèy pou Siviv ... Tips for Dealing with Grief due to the Oil Spill Disaster English Konsèy pou Kontwole Chagren -- Akòz Katastwòf ...

460

Health Information in Khmer (Khmer): MedlinePlus  

MedlinePLUS

... Coping with Disasters Tips for Coping with the Oil Spill Disaster -- Managing Your Stress - English Khmer (Khmer) PDF ... Tips for Dealing with Grief Due to the Oil Spill Disaster - English Khmer (Khmer) PDF Substance Abuse and ...

461

Health Information in Haitian Creole (Kreyol): MedlinePlus  

MedlinePLUS

... Coping with Disasters Tips for Coping with the Oil Spill Disaster -- Managing Your Stress - English Konsèy pou Siviv ... Tips for Dealing with Grief due to the Oil Spill Disaster - English Konsèy pou Kontwole Chagren -- Akòz Katastwòf ...

462

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... Coping with Disasters Tips for Coping with the Oil Spill Disaster -- Managing Your Stress - English Lao (Laotian) PDF ... Tips for Dealing with Grief Due to the Oil Spill Disaster - English Lao (Laotian) PDF Substance Abuse and ...

463

Health Information in Turkish (Türkçe): MedlinePlus  

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... Information in Turkish (Türkçe) B Bacterial Infections Pneumococcal Polysaccharide Vaccine (PPV23) - English Polisakkarid Pnömokok A?isi - Türkçe (Turkish) ... Coalition; Centers for Disease Control and Prevention Pneumococcal Polysaccharide Vaccine (PPV23) - English Polisakkarid Pnömokok A?isi - Türkçe (Turkish) ...

464

Getting Tested | NIH MedlinePlus the Magazine  

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... or healthcare provider can tell if you have COPD, and if so, how severe it is. The spirometry reading can help them to determine the best course of treatment. How Spirometry Works Spirometry is one of the ...

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Makerere University Student Interview Transcript: MedlinePlus  

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... bushy compound. NN: To convince them that the bushes are a factor in malaria is a bit ... with simplified tools, (drawing of houses with few bushes around) and examples, it comes around easier. NI: ...

466

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... to ask when you learn about a new medical finding: Was it a study in the laboratory, in animals, or in people? ... result. If a drug is being tested, the study might be partly or fully paid for ... source of medical news? Some large publications and broadcast stations have ...

467

Osteoarthritis: Research Findings | NIH MedlinePlus the Magazine  

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... studying: Tools to detect osteoarthritis earlier Genes Tissue engineering—special ways to grow cartilage to replace damaged ... athletes from these injuries. Discovery of the various genetic mutations leading to osteoarthritis could lead to new ...

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The Visible Humans | NIH MedlinePlus the Magazine  

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... NLM who led the development of the Visible Human Project. "People around the world can and do use the images in a variety of ways. They have been used to help students learn anatomy; or to develop products like artificial limbs; or ...

469

Diverticulosis and Diverticulitis - Multiple Languages: MedlinePlus  

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... on this page, please enable JavaScript. Diverticulosis and Diverticulitis - Multiple Languages Arabic (???????) French (français) Russian (???????) ... ???????? - ??????? Multimedia Patient Education Institute French ... Diverticulite - français (French) Bilingual PDF Health Information Translations ...

470

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... comparable, reasonable options for treating moderate, chronic low back pain. Researchers in Washington state studied nearly 230 people who tried to ease their low back pain one of three ways: taking yoga classes, taking ...

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... of uric acid (hyperuricemia) Presence of uric acid crystals in joint fluid More than one attack of ... is examined under a microscope for uric acid crystals. However, not finding the crystals doesn’t always ...</