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Last update: November 12, 2013.
1

Dialysis Search Filters for PubMed, Ovid MEDLINE, and Embase Databases  

PubMed Central

Summary Background and objectives Physicians frequently search bibliographic databases, such as MEDLINE via PubMed, for best evidence for patient care. The objective of this study was to develop and test search filters to help physicians efficiently retrieve literature related to dialysis (hemodialysis or peritoneal dialysis) from all other articles indexed in PubMed, Ovid MEDLINE, and Embase. Design, setting, participants, & measurements A diagnostic test assessment framework was used to develop and test robust dialysis filters. The reference standard was a manual review of the full texts of 22,992 articles from 39 journals to determine whether each article contained dialysis information. Next, 1,623,728 unique search filters were developed, and their ability to retrieve relevant articles was evaluated. Results The high-performance dialysis filters consisted of up to 65 search terms in combination. These terms included the words “dialy” (truncated), “uremic,” “catheters,” and “renal transplant wait list.” These filters reached peak sensitivities of 98.6% and specificities of 98.5%. The filters’ performance remained robust in an independent validation subset of articles. Conclusions These empirically derived and validated high-performance search filters should enable physicians to effectively retrieve dialysis information from PubMed, Ovid MEDLINE, and Embase.

Iansavichus, Arthur V.; Haynes, R. Brian; Lee, Christopher W.C.; Wilczynski, Nancy L.; McKibbon, Ann; Shariff, Salimah Z.; Blake, Peter G.; Lindsay, Robert M.

2012-01-01

2

The use of PubMed/Medline in psychiatry. 1: Presentation of NLM and PubMed.  

PubMed

A comprehensive view of the available literature on a psychiatric problem can be found in the large electronic databases. Medline at the National Library of Medicine (NLM) in USA is the largest medical database. PubMed is the searchable database at the NLM, having Medline as its major content. PubMed is free of charge, barrier-free and always accessible via the Internet. This paper describes the NLM, Medline and PubMed. The indexing of scientific papers in Medline is based on Medical Subject Headings, the MeSH terms. The hierarchic tree structure of MeSH is the basis of the search and retrieval system. The present paper is the first in a series of three, intended as a tutorial on the use of PubMed for inexperienced users. Information and examples on the MeSH system, together with exercises in its use, are presented in an appendix. PMID:16923639

Theander, Sten S

2006-01-01

3

OvidSP Medline-to-PubMed search filter translation: a methodology for extending search filter range to include PubMed's unique content  

PubMed Central

Background PubMed translations of OvidSP Medline search filters offer searchers improved ease of access. They may also facilitate access to PubMed’s unique content, including citations for the most recently published biomedical evidence. Retrieving this content requires a search strategy comprising natural language terms (‘textwords’), rather than Medical Subject Headings (MeSH). We describe a reproducible methodology that uses a validated PubMed search filter translation to create a textword-only strategy to extend retrieval to PubMed’s unique heart failure literature. Methods We translated an OvidSP Medline heart failure search filter for PubMed and established version equivalence in terms of indexed literature retrieval. The PubMed version was then run within PubMed to identify citations retrieved by the filter’s MeSH terms (Heart failure, Left ventricular dysfunction, and Cardiomyopathy). It was then rerun with the same MeSH terms restricted to searching on title and abstract fields (i.e. as ‘textwords’). Citations retrieved by the MeSH search but not the textword search were isolated. Frequency analysis of their titles/abstracts identified natural language alternatives for those MeSH terms that performed less effectively as textwords. These terms were tested in combination to determine the best performing search string for reclaiming this ‘lost set’. This string, restricted to searching on PubMed’s unique content, was then combined with the validated PubMed translation to extend the filter’s performance in this database. Results The PubMed heart failure filter retrieved 6829 citations. Of these, 834 (12%) failed to be retrieved when MeSH terms were converted to textwords. Frequency analysis of the 834 citations identified five high frequency natural language alternatives that could improve retrieval of this set (cardiac failure, cardiac resynchronization, left ventricular systolic dysfunction, left ventricular diastolic dysfunction, and LV dysfunction). Together these terms reclaimed 157/834 (18.8%) of lost citations. Conclusions MeSH terms facilitate precise searching in PubMed’s indexed subset. They may, however, work less effectively as search terms prior to subject indexing. A validated PubMed search filter can be used to develop a supplementary textword-only search strategy to extend retrieval to PubMed’s unique content. A PubMed heart failure search filter is available on the CareSearch website (http://www.caresearch.com.au) providing access to both indexed and non-indexed heart failure evidence.

2013-01-01

4

Agreement between Medline searches using the Medline-CD-Rom and Internet PubMed, BioMedNet, Medscape and Gateway search-engines  

Microsoft Academic Search

Objective To compare the information obtained from the Medline database using Internet commercial search engines with that obtained from a compact disc (Medline-CD). Methods An agreement study was carried out based on 101 clinical sce- narios provided by specialists in internal medicine, pharmacy, gynaecology- obstetrics, surgery and paediatrics. 175 search strategies were employed using the connector AND plus text within

Rosa Ángela Caro-Rojas; Javier H. Eslava-Schmalbach

2005-01-01

5

Social Networks in Education of Health Professionals in Bosnia and Herzegovina - the Role of Pubmed/Medline in Improvement of Medical Sciences  

PubMed Central

Introduction: Social network is a social structure made up of individuals and organizations that represent “nodes”, and they are associated with one or more types of interdependency; such as: friendship, common interests, work, knowledge, prestige and many other interests. Beginning with the late twentieth and early twenty-first century, the Internet was a significant additional tool in the education of teenagers. Later, it takes more and more significant role in educating students and professionals. Goal: The aim of this paper is to investigate, to what extent and how effectively the Internet is used today. In addition, more specifically, this paper will research the implications of the well-known social networks in education of students and health professionals in Bosnia and Herzegovina (B&H). Material and methods: We compared the ratio of using Medline, as the largest biomedical data base system for spreading medical information, as basics for health education at biomedical faculties at five universities in B&H. Results and discussion: According to data from the CRA (i.e. Communications Regulatory Agency) in B&H, in 2010, there were 522,364 internet access accounts, with about 2 million Internet users, representing about 52% of the total population. The Internet users’ preference is dominated by the users of fast broadband access (e.g. xDSL) with 42.8%, and elsewhere, still with dialup access, with 25.2%. The results showed that only 11.6% of professors use Facebook type of social network, 49.3% of them have a profile on BiomedExperts scientific social network and 79% have available articles in the largest biomedical literature database MEDLINE. Students are also frequent users of general social networks and educational clips from You Tube, which they prefer to utilize considerably more than the other types of professionals. Students rarely use the facilities of professional social networks, because they contain mainly data and information needed for further, postgraduate professional education. In our research, we analized cited published papers in the journal Medical Archives, the oldest medical journal in B&H (established in 1947) of randomly included 151 full and part time professors, authors from five medical faculties in B&H and B&H authors who currently work in the EU and USA.. ANOVA showed that there was no significant difference in the number of articles published between the Universities in Bosnia, but there was significant difference in the number of articles published on MEDLINE, between all faculties in B&H and a group of scientists who work around the world. Students’ tests showed that there was a statistically significant difference in the average number of papers published on Medline, between groups of part-time and full time professors. However, there were no statistically significant differences, between the professors for preclinical and clinical subjects. Conclusion: In B&H there are decent conditions for the use of online social networks in the education of health professionals. While students enthusiastically embraced these opportunities, this is not so much a case with health care professionals in practice; while scientific health care workers have not shown greater interest in the use of social networks, both for purposes of scientific research and in terms of self-education and training of students. There is much more use of the advantages offered by online social networks, both in education and in support of the scientific research.

Masic, Izet; Sivic, Suad

2011-01-01

6

Cancer Literature in PubMed  

Cancer.gov

PubMed, a service of the National Library of Medicine, provides access to over 12 million MEDLINE literature citations dating back to the mid-1960s. PubMed also includes links to many full-text articles at journal Web sites as well as links to related Web resources.

7

PubMed Tutorial  

NSDL National Science Digital Library

PubMed Tutorial is a "web-based learning program that will show you how to search PubMed, the National Library of Medicine's journal literature search system." Clear, detailed explanations and helpful animations guide users in making the most of PubMed's many features. The level of detail in this tutorial is amazing, yet not overwhelming (thanks again to animations and demonstrations that replicate the PubMed user interface). A final review section offers a number of practice exercises.

2008-05-07

8

MEDLINE PLUS  

EPA Science Inventory

MEDLINE plus is the National Library of Medicine's web site for consumer health information. MEDLINE plus has extensive information from the National Institutes of Health and other trusted sources on over 600 diseases and conditions. There are also lists of hospitals and physicia...

9

The Cochrane Collaboration.  

PubMed

The Cochrane Collaboration is an international, not-for-profit organisation that aims to help people make well-informed decisions about health care by preparing, maintaining and promoting the accessibility of systematic reviews of the effects of health-care interventions. Cochrane systematic reviews are prepared according to predefined, explicit methodology, and published in The Cochrane Library. The abstracts and plain English summaries of the reviews are freely available on the Internet. All reviews are prepared and maintained under the editorial control of 50 Cochrane Collaborative Review Groups that focus on (groups of) health problems. The work of Collaborative Review Groups is supported, among others, by people working in Cochrane Fields. Cochrane Fields focus on dimensions of health care other than health problems. To date, the issue of nutrition has not been addressed sufficiently in The Cochrane Collaboration. Nutrition issues are very important for day-to-day health care and the initiatives to establish a new Cochrane Diet and Nutrition (Sub)Field will help to promote the preparation of systematic reviews of nutritional interventions by the variety of Collaborative Review Groups to whom such interventions are relevant. Many issues regarding nutritional interventions, however, are complex, and methodological challenges will have to be overcome. A Cochrane Diet and Nutrition (Sub)Field with experts on nutritional research can help fill this gap and make those reviews more possible. PMID:16052183

Scholten, R J P M; Clarke, M; Hetherington, J

2005-08-01

10

A Primer: Basic PubMed Searching for Pharmacists  

Microsoft Academic Search

Electronic database searching has become more prevalent, especially with the proliferation of Internet full-text databases. PubMed provides free access to MEDLINE, which is the largest biomedical data- base, which provides over 14 million citations since the mid-1960s. This resource is accessible free through the Internet and indexes over 4,800 medical journals. PubMed certainly has implications for drug usage and research,

Robert H. Schrimsher; Michael G. Kendrach

2006-01-01

11

Internet Medline providers.  

PubMed

Each database in this review has features that will appeal to some users. Each provides a credible interface to information available within the Medline database. The major differences are pricing and interface design. In this context, features that cost more and might seem trivial to the occasional searcher may actually save time and money when used by the professional. Internet Grateful Med is free, but Ms. Coady and I agree the availability of only three ANDable search fields is a major functional limitation. PubMed is also free but much more powerful. The command line interface that permits very sophisticated searches requires a commitment that casual users will find intimidating. Ms. Coady did not believe the feedback currently provided during a search was sufficient for sustained professional use. Paper Chase and Knowledge Finder are mature, modestly priced Medline search services. Paper Chase provides a menu-driven interface that is very easy to use, yet permits the user to search virtually all of Medline's data fields. Knowledge Finder emphasizes the use of natural language queries but fully supports more traditional search strategies. The impact of the tradeoff between fuzzy and Boolean strategies offered by Knowledge Finder is unclear and beyond the scope of this review. Additional software must be downloaded to use all of Knowledge Finders' features. Other providers required no software beyond the basic Internet browser, and this requirement prevented Ms. Coady from evaluating Knowledge Finder. Ovid and Silver Platter offer well-designed interfaces that simplify the construction of complex queries. These are clearly services designed for professional users. While pricing eliminates these for casual use, it should be emphasized that Medline citation access is only a portion of the service provided by these high-end vendors. Finally, we should comment that each of the vendors and government-sponsored services provided prompt and useful feedback to e-mail questions about usage. In conclusion, we would suggest you try the various services, determine which interface suits your style and budget, then perform simple searches until you learn the strengths and weaknesses of the service you select. PMID:10662266

Vine, D L; Coady, T R

12

The Cochrane Collaboration: the role of the UK Cochrane Centre in identifying the evidence.  

PubMed

This paper attempts to explain why systematic reviews of randomized controlled trials, based on as high a proportion as possible of the relevant studies, are so important in generating reliable information for evidence-based decision making within health care. The preparation, maintenance and dissemination of such reviews is the challenge which has been taken up by the Cochrane Collaboration. The first phase of data collection is the identification of relevant studies. Currently, bibliographic databases are inadequate for this task. MEDLINE searches identify on average only about half of the relevant studies, and until 1994 there were no suitable indexing terms in EMBASE to identify randomized controlled trials. Co-operation between the Cochrane Collaboration and both the National Library of Medicine and Elsevier, however, is already transforming this situation. From January 1994 a new indexing term has been added to EMBASE to help identify randomized controlled trials. From January 1995 a new indexing term will be added to MEDLINE to help identify controlled trials where the method of allocation to treatment or control cannot be described with certainty as being randomized. Also from January 1995 an additional 20,000 reports will be identifiable as randomized controlled trials in MEDLINE. Progress during the first 2 years of the Cochrane Collaboration has been encouraging, but much remains to be done if users of health services are to benefit from the evidence-based health care which they deserve. PMID:10141711

Lefebvre, C

1994-12-01

13

The Pitfalls of a Systematic MEDLINE Review in Palliative Medicine: Symptom Assessment Instruments  

Microsoft Academic Search

The Medical Literature Analysis and Retrieval System Online (MEDLINE) database provides many references for reviews, but many relevant articles are missed, especially when the topic is complex. Reported here is the detailed methodology of a PubMed search of MEDLINE augmented by a related articles link search. Of 1181 citations identified, through a PubMed search, 10 articles met the inclusion criteria.

Norma OLeary; Eoin Tiernan; Declan Walsh; Niamh Lucey; Jordanka Kirkova; Mellar P. Davis

2007-01-01

14

The MEDLINE Retriever.  

PubMed Central

Baylor College of Medicine has developed the MEDLINE Retriever, a tool to query MEDLINE, the data-base of medical literature at the National Library of Medicine. The MEDLINE Retriever communicates via the Internet to achieve excellent response time for MEDLINE queries. It uses the X Window System and the Motif toolkit, and employs the Knowbot Operating Environment developed by the Corporation for National Research Initiatives. We discuss the architecture of the MEDLINE Retriever, focusing on the graphical user interface that we have developed, as well as our experiences in developing and deploying the MEDLINE Retriever at Baylor. The MEDLINE Retriever is an extension of Baylor's IAIMS design concept that brought forth the Virtual Notebook System, and fits well with Baylor's aims with regard to the High Performance Computing Initiative.

Fowler, J.; Barber, S.; Gilson, H.; Long, K. B.; Gorry, G. A.

1992-01-01

15

Anticonvulsants in migraine prophylaxis: a Cochrane review.  

PubMed

Several trials have asserted that some anticonvulsant drugs seem to be useful for the prophylaxis of migraine, but systematic reviews are sparse. We independently searched PubMed, EMBASE and the Cochrane Central Register of Controlled Trials until 2005, as well as Headache and Cephalalgia through April 2006, for prospective, controlled trials of anticonvulsant drugs. Data were calculated and pooled across studies and expressed as standardized mean differences, odds ratios and numbers-needed-to-treat. Anticonvulsants, considered as a class, reduce migraine frequency by about 1.3 attacks per 28 days compared with placebo, and more than double the number of patients for whom migraine frequency is reduced by > or = 50% relative to placebo. Sodium valproate/divalproex sodium and topiramate were better than placebo, whereas acetazolamide, clonazepam, lamotrigine and vigabatrin were not; gabapentin, in particular, needs further evaluation. Trials designed with sufficient power to compare different drugs are also necessary. PMID:18454787

Mulleners, W M; Chronicle, E P

2008-06-01

16

McMaster Premium LiteratUre Service (PLUS) performed well for identifying new studies for updated Cochrane reviews  

Microsoft Academic Search

ObjectiveWe compared the performance of McMaster Premium LiteratUre Service (PLUS) and Clinical Queries (CQs) to that of the Cochrane Controlled Trials Register, MEDLINE, and EMBASE for locating studies added during an update of reviews.

Brian J. Hemens; R. Brian Haynes

17

MEDLINE SDI services: how do they compare?*  

PubMed Central

Introduction: Selective dissemination of information (SDI) services regularly alert users to new information on their chosen topics. This type of service can increase a user's ability to keep current and may have a positive impact on efficiency and productivity. Currently, there are many venues available where users can establish, store, and automatically run MEDLINE searches. Purpose: To describe, evaluate, and compare SDI services for MEDLINE. Resources: The following SDI services were selected for this study: PubMed Cubby, BioMail, JADE, PubCrawler, OVID, and ScienceDirect. Methodology: Identical searches were established in four of the six selected SDI services and were run on a weekly basis over a period of two months. Eight search strategies were used in each system to test performance under various search conditions. The PubMed Cubby system was used as the baseline against which the other systems were compared. Other aspects were evaluated in all six services and include ease of use, frequency of results, ability to use MeSH, ability to access and edit existing search strategies, and ability to download to a bibliographic management program. Results: Not all MEDLINE SDI services retrieve identical results, even when identical search strategies are used. This study also showed that the services vary in terms of features and functions offered.

Shultz, Mary; De Groote, Sandra L.

2003-01-01

18

WHAT IS A COCHRANE REVIEW?  

PubMed Central

In this era of evidence-based practice, it is important for nurses in all settings to understand and have access to high-quality systematic reviews of published evidence. This paper introduces a premier resource, the Cochrane Collaboration, and reviews mechanisms for accessing its published systematic reviews from any practice setting.

Sieving, Pamela C.

2008-01-01

19

Finding related sentence pairs in MEDLINE  

PubMed Central

We explore the feasibility of automatically identifying sentences in different MEDLINE abstracts that are related in meaning. We compared traditional vector space models with machine learning methods for detecting relatedness, and found that machine learning was superior. The Huber method, a variant of Support Vector Machines which minimizes the modified Huber loss function, achieves 73% precision when the score cutoff is set high enough to identify about one related sentence per abstract on average. We illustrate how an abstract viewed in PubMed might be modified to present the related sentences found in other abstracts by this automatic procedure.

Wilbur, W. John

2010-01-01

20

Anabolic-androgenic steroids for alcoholic liver disease: a Cochrane Review  

Microsoft Academic Search

OBJECTIVES:The objectives were to assess the beneficial and harmful effects of anabolic-androgenic steroids for alcoholic liver disease.METHODS:The Cochrane Hepato-Biliary Group Controlled Trials Register, The Cochrane Library, MEDLINE, EMBASE, and full text searches were combined. Only randomized clinical trials studying patients with alcoholic liver disease were included. Interventions encompassed anabolic-androgenic steroids at any dose or duration versus placebos or no intervention.

Andrea Rambaldi; Gaetano Iaquinto; Christian Gluud

2002-01-01

21

Anabolic-androgenic steroids for alcoholic liver disease: a Cochrane Review 1 1 This article represents a condensed version of a systematic Cochrane Review submitted to The Cochrane Library. The protocol for this review was published in The Cochrane Library, No. 2, 2001  

Microsoft Academic Search

OBJECTIVES:The objectives were to assess the beneficial and harmful effects of anabolic-androgenic steroids for alcoholic liver disease.METHODS:The Cochrane Hepato-Biliary Group Controlled Trials Register, The Cochrane Library, MEDLINE, EMBASE, and full text searches were combined. Only randomized clinical trials studying patients with alcoholic liver disease were included. Interventions encompassed anabolic-androgenic steroids at any dose or duration versus placebos or no intervention.

Andrea Rambaldi; Gaetano Iaquinto; Christian Gluud

2002-01-01

22

Cochrane review protocols 2012-3.  

PubMed

Commentaries on Cochrane reviews form a core part of the content of the Evidence-based Dentistry Journal. Protocols for Cochrane review are published on Cochrane library (www.thecochranelibrary.com) after peer review occasionally reviews are published a short time later but more often it take more than a year for the final review to appear. In this new section of the journal we are planning to list the protocols from the Cochrane Oral Health Group (http://ohg.cochrane.org/) and dentally relevant protocols from other Cochrane Groups on a annual basis. PMID:24071684

2013-09-01

23

Physical Conditioning Programs for Workers With Back and Neck Pain: A Cochrane Systematic Review  

Microsoft Academic Search

Objective. To determine the effect on time lost from work of physical conditioning programs for workers with back and neck pain. Data Sources. Randomized trials were located by searching MEDLINE, EMBASE, CINAHL, PsycINFO, the Cochrane Controlled Trial Register, and PEDro. Review Methods. Two reviewers independently ex- tracted data and assessed trial quality. Where data could be pooled, meta-analysis was performed.

Eva Schonstein; D. Kenny; J. Keating; B. Koes; R. D. Herbert

24

Happy 20th birthday to the cochrane collaboration.  

PubMed

To learn more about the history of the Cochrane Collaboration visit the Cochrane Collaboration website (http://www.cochrane.org/about-us/history), the Cochrane Collaboration 20th Anniversary website (http://anniversary.cochrane.org/), and watch the You Tube Cochrane 20 Video Series (http://www.youtube.com/user/CochraneCollab). PMID:24020474

Crenshaw, Jeannette T

2013-09-04

25

Evaluation of Query Expansion Using MeSH in PubMed  

PubMed Central

This paper investigates the effectiveness of using MeSH® in PubMed through its automatic query expansion process: Automatic Term Mapping (ATM). We run Boolean searches based on a collection of 64 topics and about 160,000 MEDLINE® citations used in the 2006 and 2007 TREC Genomics Tracks. For each topic, we first automatically construct a query by selecting keywords from the question. Next, each query is expanded by ATM, which assigns different search tags to terms in the query. Three search tags: [MeSH Terms], [Text Words], and [All Fields] are chosen to be studied after expansion because they all make use of the MeSH field of indexed MEDLINE citations. Furthermore, we characterize the two different mechanisms by which the MeSH field is used. Retrieval results using MeSH after expansion are compared to those solely based on the words in MEDLINE title and abstracts. The aggregate retrieval performance is assessed using both F-measure and mean rank precision. Experimental results suggest that query expansion using MeSH in PubMed can generally improve retrieval performance, but the improvement may not affect end PubMed users in realistic situations.

Lu, Zhiyong; Kim, Won; Wilbur, W. John

2009-01-01

26

McMaster Premium Literature Service (Plus) Performs Well for Identifying New Studies to be Included in Updated Cochrane Systematic Reviews  

Microsoft Academic Search

Objective: We compared the performance of PLUS to that ofthe Cochrane Trial Registry (CCTR), Medline and EMBASE for locating studies added during an update of Cochrane Systematic reviews. We investigated the effect of excluding studies not found in PLUS on meta-analysis results.\\u000aStudy Design and Setting: A sample of new studies in updated Cochrane Systematic Reviews was used to establish

Briam Hemens

2010-01-01

27

Acta Informatica Medica Is Indexed In Pubmed And Archived In Pubmed Central  

PubMed Central

Acta Informatica Medica journal has been accepted for archiving in PubMed Central from 2011 onward. The journal started in 1993 as the official journal of the Society for Medical Informatics of Bosnia and Herzegovina. During the last 3 years, Acta Informatica Medica has een included in almost all prestigious online databases, including PubMed, Scopus and EMBASE. The 20th volume of the journal is fully international, with papers from 18 countries.

Masic, Izet

2013-01-01

28

Finding biomedical categories in Medline®  

PubMed Central

Background There are several humanly defined ontologies relevant to Medline. However, Medline is a fast growing collection of biomedical documents which creates difficulties in updating and expanding these humanly defined ontologies. Automatically identifying meaningful categories of entities in a large text corpus is useful for information extraction, construction of machine learning features, and development of semantic representations. In this paper we describe and compare two methods for automatically learning meaningful biomedical categories in Medline. The first approach is a simple statistical method that uses part-of-speech and frequency information to extract a list of frequent nouns from Medline. The second method implements an alignment-based technique to learn frequent generic patterns that indicate a hyponymy/hypernymy relationship between a pair of noun phrases. We then apply these patterns to Medline to collect frequent hypernyms as potential biomedical categories. Results We study and compare these two alternative sets of terms to identify semantic categories in Medline. We find that both approaches produce reasonable terms as potential categories. We also find that there is a significant agreement between the two sets of terms. The overlap between the two methods improves our confidence regarding categories predicted by these independent methods. Conclusions This study is an initial attempt to extract categories that are discussed in Medline. Rather than imposing external ontologies on Medline, our methods allow categories to emerge from the text.

2012-01-01

29

Fifteenth biannual report of the Cochrane Haematological Malignancies Group--focus on non-Hodgkin's lymphoma.  

PubMed

This fifteenth biannual report of the Cochrane Haematological Malignancies Group (CHMG) highlights recently published randomized controlled trials (RCTs) in the field of hemato-oncology, covering the publication period from October 2011 to May 2012. Implications for clinical practice and methodological aspects are the main principles for selecting trials for this report. Studies were identified by electronic search of MEDLINE using a broad search filter that covers all topics in hemato-oncology combined with a highly sensitive search filter for randomized trials (Cochrane Handbook for Systematic Reviews of Interventions). PMID:23852951

Rancea, Michaela; Will, Andrea; Borchmann, Peter; Monsef, Ina; Engert, Andreas; Skoetz, Nicole

2013-07-12

30

Twelfth biannual report of the Cochrane Haematological Malignancies Group--focus on tyrosine kinase inhibitors.  

PubMed

This 12th biannual report of the Cochrane Haematological Malignancies Group highlights recently published randomized controlled trials in the field of hemato-oncology, covering the publication period from September 1, 2009, through June 30, 2010. Implication for clinical practice and methodological aspects are the main principles used to select trials for this report. Studies on tyrosine kinase inhibitors for patients with chronic myeloid leukemia were identified through electronic search of MEDLINE with a broad search filter that covered all topics in hemato-oncology combined with a highly sensitive search filter for randomized studies as described in the Cochrane Handbook for Systematic Reviews of Interventions. PMID:21252264

Skoetz, Nicole; Kluge, Sabine; Monsef, Ina; Bauer, Kathrin; Siebert, Hendrik; Kreuzer, Karl-Anton; Engert, Andreas

2011-01-20

31

GenBank and PubMed: How connected are they?  

PubMed Central

Background GenBank(R) is a public repository of all publicly available molecular sequence data from a range of sources. In addition to relevant metadata (e.g., sequence description, source organism and taxonomy), publication information is recorded in the GenBank data file. The identification of literature associated with a given molecular sequence may be an essential first step in developing research hypotheses. Although many of the publications associated with GenBank records may not be linked into or part of complementary literature databases (e.g., PubMed), GenBank records associated with literature indexed in Medline are identifiable as they contain PubMed identifiers (PMIDs). Results Here we show that an analysis of 87,116,501 GenBank sequence files reveals that 42% are associated with a publication or patent. Of these, 71% are associated with PMIDs, and can therefore be linked to a citation record in the PubMed database. The remaining (29%) of publication-associated GenBank entries either do not have PMIDs or cite a publication that is not currently indexed by PubMed. We also identify the journal titles that are linked through citations in the GenBank files to the largest number of sequences. Conclusion Our analysis suggests that GenBank contains molecular sequences from a range of disciplines beyond biomedicine, the initial scope of PubMed. The findings thus suggest opportunities to develop mechanisms for integrating biological knowledge beyond the biomedical field.

Miller, Holly; Norton, Catherine N; Sarkar, Indra Neil

2009-01-01

32

SPELLING CORRECTION IN THE PUBMED SEARCH ENGINE.  

PubMed

It is known that users of internet search engines often enter queries with misspellings in one or more search terms. Several web search engines make suggestions for correcting misspelled words, but the methods used are proprietary and unpublished to our knowledge. Here we describe the methodology we have developed to perform spelling correction for the PubMed search engine. Our approach is based on the noisy channel model for spelling correction and makes use of statistics harvested from user logs to estimate the probabilities of different types of edits that lead to misspellings. The unique problems encountered in correcting search engine queries are discussed and our solutions are outlined. PMID:18080004

Wilbur, W John; Kim, Won; Xie, Natalie

2006-11-01

33

SPELLING CORRECTION IN THE PUBMED SEARCH ENGINE  

PubMed Central

It is known that users of internet search engines often enter queries with misspellings in one or more search terms. Several web search engines make suggestions for correcting misspelled words, but the methods used are proprietary and unpublished to our knowledge. Here we describe the methodology we have developed to perform spelling correction for the PubMed search engine. Our approach is based on the noisy channel model for spelling correction and makes use of statistics harvested from user logs to estimate the probabilities of different types of edits that lead to misspellings. The unique problems encountered in correcting search engine queries are discussed and our solutions are outlined.

Wilbur, W. John; Kim, Won; Xie, Natalie

2007-01-01

34

Mobile MedlinePlus | NIH MedlinePlus Magazine  

MedlinePLUS

... Table of Contents Trusted medical information on your mobile phone http://m.medlineplus.gov Wondering what the side effects are for your new prescription? Go to Mobile MedlinePlus while you're waiting for the pharmacist ...

35

Mobile MedlinePlus | NIH MedlinePlus the Magazine  

MedlinePLUS

... Table of Contents Trusted medical information on your mobile phone http://m.medlineplus.gov Wondering what the side effects are for your new prescription? Go to Mobile MedlinePlus ( http://m.medlineplus.gov ) while you're ...

36

The pitfalls of a systematic MEDLINE review in palliative medicine: symptom assessment instruments.  

PubMed

The Medical Literature Analysis and Retrieval System Online (MEDLINE) database provides many references for reviews, but many relevant articles are missed, especially when the topic is complex. Reported here is the detailed methodology of a PubMed search of MEDLINE augmented by a related articles link search. Of 1181 citations identified, through a PubMed search, 10 articles met the inclusion criteria. Fifty-one were identified through the related articles link; of which 43 were not detected by standard searches using medical subject heading terms. More than 50% were identified using the related articles link. Only 14% of relevant articles were identified using the standard PubMed MEDLINE search. The related articles link is not included in methodologic recommendations for systematic literature reviews but this experience suggests that it is a useful tool in PubMed for reviewing complex evidence. Related links searches are proposed in any systematic PubMed MEDLINE literature review in palliative medicine. PMID:17601840

O'Leary, Norma; Tiernan, Eoin; Walsh, Declan; Lucey, Niamh; Kirkova, Jordanka; Davis, Mellar P

37

Cochrane corner: local corticosteroid injection for carpal tunnel syndrome.  

PubMed

Background: Carpal tunnel syndrome is a clinical syndrome manifested by signs and symptoms of irritation of the median nerve at the carpal tunnel in the wrist. Local corticosteroid injection for carpal tunnel syndrome has been studied but its effectiveness is unknown. Objectives: To evaluate the effectiveness of local corticosteroid injection for carpal tunnel syndrome versus placebo injection or other non-surgical interventions. Search methods: We searched the Cochrane Neuromuscular Disease Group Trials register (searched May 2006), MEDLINE (searched January 1966 to May 2006), EMBASE (searched January 1980 to May 2006) and CINAHL (searched January 1982 to May 2006). Selection criteria: Randomized or quasi-randomized studies. Data collection and analysis: Three authors independently selected the trials and rated their overall quality. Relative risks and 95% confidence intervals were calculated for each trial and summary relative risks and 95% confidence intervals were also calculated. PMID:24065747

Stark, H; Amirfeyz, R

2013-10-01

38

Health Topics: MedlinePlus  

MedlinePLUS

... features on this page, please enable JavaScript. Health Topics Read about symptoms, causes, treatment and prevention for ... illnesses, health conditions and wellness issues. MedlinePlus health topics are regularly reviewed, and links are updated daily. ...

39

MEDLINE in the UK: pioneering the past, present and future.  

PubMed

This article provides a brief history of the development of the MEDLINE database and its huge impact within the UK, from its inception to the present time. The origins of MEDLINE can be traced back to a collection of books in the US Surgeon General's Office during the American Civil War and John Shaw Billings' decision, during 1867, to make this Library as complete as possible. From these beginnings, Index Medicus was developed in the early years of the 20th century, and electronic versions of the database began with the computerized on-demand search service MEDLARS in 1964 and then via CD-ROM and Internet Grateful Med to the web-based and free-to-all service, PubMed, in 1997. The response to PubMed was immediate and startling with usage increasing from 7 million searches per annum in 1996 to 400 million searches per annum in 2001 and the service continues to improve. MEDLINE providers are now offering mapping of natural language queries to the sophisticated indexing vocabulary (Medical Subject Headings, MeSH) and the provision of specific filters for different types of publication to improve searching efficiency, as well as links to full-text versions of the papers where available. The next steps are likely to involve an increased blurring of database and full-text boundaries, incorporating seamless access to the best available evidence within MEDLINE and a wide range of other information resources within a single search and to an increasing amount of full-text via various open-archive initiatives. As ever, the US National Library of Medicine is in the vanguard of research and further applications of its MEDLINE database for users within the UK will be awaited with great interest. PMID:16109026

Pritchard, Steve J; Weightman, Alison L

2005-09-01

40

Medicinal Herbs for Hepatitis C Virus Infection: A Cochrane Hepatobiliary Systematic Review of Randomized Trials  

Microsoft Academic Search

OBJECTIVE:The aim of this study was to assess beneficial and harmful effects of medicinal herbs for hepatitis C virus (HCV) infection.METHODS:The databases of the Cochrane Collaboration, MEDLINE, EMBASE, and BIOSIS were searched combined with manual searches of five Chinese and one Japanese journals. We included randomized trials comparing medicinal herbs with placebo, no intervention, nonspecific treatment, other herbs, or interferon

Jianping Liu; Eric Manheimer; Kiichiro Tsutani; Christian Gluud

2003-01-01

41

Sharing MedlinePlus®/MEDLINE for Information Literacy Education (SMILE): A Dental Public Health Information Project  

PubMed Central

The SMILE project represented a partnership among the University of Texas Health Science Center at San Antonio Libraries, the Gateway Clinic in Laredo, and the San Antonio Metropolitan Health District. The project focused on improving dental practitioners' access to reliable information resources and integrating the best evidence into public health dental practice. Through its training program, SMILE cultivated a set of “power information users” among the dentists, dental hygienists, and community health workers (promotores) who provide public health preventive care and oral health education. The dental public health practitioners gained information literacy skills and increased their knowledge about reliable sites such as blogs, PubMed®, and MedlinePlus®. This project fostered opportunities for expanded partnerships with public health personnel.

Gaines, Julie K.; Levy, Linda S.; Cogdill, Keith W.

2012-01-01

42

Sharing MedlinePlus®/MEDLINE® for information literacy education (SMILE): a dental public health information project.  

PubMed

The SMILE project represented a partnership among the University of Texas Health Science Center at San Antonio Libraries, the Gateway Clinic in Laredo, and the San Antonio Metropolitan Health District. The project focused on improving dental practitioners' access to reliable information resources and integrating the best evidence into public health dental practice. Through its training program, SMILE cultivated a set of "power information users" among the dentists, dental hygienists, and community health workers (promotores) who provided public health preventive care and oral health education. The dental public health practitioners gained information literacy skills and increased their knowledge about reliable sites such as blogs, PubMed®, and MedlinePlus®. This project fostered opportunities for expanded partnerships with public health personnel. PMID:22040242

Gaines, Julie K; Levy, Linda S; Cogdill, Keith W

2011-01-01

43

MedlinePlus Survey Results 2011  

MedlinePLUS

... Topics Drugs & Supplements Videos & Cool Tools ESPAÑOL MedlinePlus Survey Results 2011 To use the sharing features on this page, please enable JavaScript. These survey results describe MedlinePlus and MedlinePlus en español users. ...

44

Modeling Actions of PubMed Users with N-Gram Language Models*  

PubMed Central

Transaction logs from online search engines are valuable for two reasons: First, they provide insight into human information-seeking behavior. Second, log data can be used to train user models, which can then be applied to improve retrieval systems. This article presents a study of logs from PubMed®, the public gateway to the MEDLINE® database of bibliographic records from the medical and biomedical primary literature. Unlike most previous studies on general Web search, our work examines user activities with a highly-specialized search engine. We encode user actions as string sequences and model these sequences using n-gram language models. The models are evaluated in terms of perplexity and in a sequence prediction task. They help us better understand how PubMed users search for information and provide an enabler for improving users’ search experience.

Lin, Jimmy; Wilbur, W. John

2008-01-01

45

Materia Socio Medica is Indexed in Pubmed and Archived in PubMed Central.  

PubMed

Materia Socio Medica Journal has been accepted for archiving in PubMed Central from 2011. The journal started in 1993 as offi cial journal of Social Medicine Association of B&H. During last 3 years Mat Soc Med has included in almost all femous on-line databases (except WoS). All issues of Mat Soc Med published in 2012 are now visible on PubMed/PubMed Central. PMID:23678332

Masic, Izet

2013-01-01

46

Materia Socio Medica is Indexed in Pubmed and Archived in PubMed Central  

PubMed Central

Materia Socio Medica Journal has been accepted for archiving in PubMed Central from 2011. The journal started in 1993 as offi cial journal of Social Medicine Association of B&H. During last 3 years Mat Soc Med has included in almost all femous on-line databases (except WoS). All issues of Mat Soc Med published in 2012 are now visible on PubMed/PubMed Central.

Masic, Izet

2013-01-01

47

MedlinePlus Connect: Web Service  

MedlinePLUS

MedlinePlus Connect: Web Service To use the sharing features on this page, please enable JavaScript. MedlinePlus Connect is available as a ... if you implement MedlinePlus Connect by contacting us . Web Service Overview The REST-based MedlinePlus Connect Web ...

48

Ribavirin Monotherapy for Chronic Hepatitis C Infection: A Cochrane HepatoBiliary Group Systematic Review and Meta-Analysis of Randomized Trials  

Microsoft Academic Search

OBJECTIVES:Adding ribavirin to interferon improves treatment response for patients with chronic hepatitis C, but the effects of ribavirin monotherapy are unclear. We conducted a systematic review to assess the benefits and harms of ribavirin monotherapy for patients with chronic hepatitis C.METHODS:Randomized trials were identified through the Cochrane Hepato-Biliary Group Controlled Trials Register, The Cochrane Library, MEDLINE, and EMBASE (last search

Jesper Brok; Lise L. Gluud; Christian Gluud

2006-01-01

49

A Cochrane systematic review finds tongue scrapers have short-term efficacy in controlling halitosis.  

PubMed

The Cochrane systematic review promotes evidence-based outcome studies. This review was conducted to determine reliable evidence concerning the effectiveness of tongue scraping or cleaning, compared with other interventions for controlling halitosis. A competent search strategy was developed and used across several databases--including the Cochrane Oral Health Group Trials Register, the Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, and Google Scholar--to identify randomized controlled trials that compared different methods of tongue cleaning to reduce mouth odor in adults with halitosis. Methodological quality of studies was assessed based on criteria defined by the Cochrane Collaboration. Clinical outcome (expressed in terms of a reduction in mouth odor in adults with halitosis) was examined. The review included two trials involving a total of 40 participants. Based on the independent data from these two trials, the tongue cleaner or the tongue scraper demonstrated a statistically significant difference in reducing levels of volatile sulfur compounds (VSCs) when compared with the toothbrush. The findings indicate a small but statistically significant difference in reduction of VSC levels when tongue scrapers or cleaners, rather than toothbrushes, are used to reduce halitosis in adults. PMID:17004573

Outhouse, Trent L; Fedorowicz, Zbigniew; Keenan, James V; Al-Alawi, Rashad

50

MedlinePlus Connect: Technical Information  

MedlinePLUS

... to keep you informed of updates and enhancements. Web Application The MedlinePlus Connect Web application responds to ... Connect response pages, visit the Web application demonstration . Web Service Using the MedlinePlus Connect Web service, a ...

51

Identification of Randomized Controlled Trials From the Emergency Medicine Literature: Comparison of Hand Searching Versus MEDLINE Searching  

Microsoft Academic Search

Study objective: As part of an ongoing project to identify all the randomized controlled trials (RCTs) in the emergency medicine literature, in association with the Cochrane Collaboration, 2 discrete studies were undertaken; the first, to compare motives for active participation in hand searching of the literature by emergency medicine professionals, and the second, to compare hand searching with MEDLINE searching

Julia Langham; Elizabeth Thompson; Kathy Rowan

1999-01-01

52

Feasibility of a Knowledge Translation CME Program: "Courriels Cochrane"  

ERIC Educational Resources Information Center

Introduction: Systematic literature reviews provide best evidence, but are underused by clinicians. Thus, integrating Cochrane reviews into continuing medical education (CME) is challenging. We designed a pilot CME program where summaries of Cochrane reviews ("Courriels Cochrane") were disseminated by e-mail. Program participants automatically…

Pluye, Pierre; Grad, Roland; Granikov, Vera; Theriault, Guylene; Fremont, Pierre; Burnand, Bernard; Mercer, Jay; Marlow, Bernard; Arroll, Bruce; Luconi, Francesca; Legare, France; Labrecque, Michel; Ladouceur, Roger; Bouthillier, France; Sridhar, Soumya Bindiganavile; Moscovici, Jonathan

2012-01-01

53

Celebrating 20 years of the international cochrane collaboration.  

PubMed

In 2013 the international Cochrane Collaboration is celebrating the 20th anniversary of its foundation with a series of events, publications, and videos. The "Cochrane Corner" has been a regular feature of Otolaryngology-Head and Neck Surgery for several years, but for those unfamiliar with the work of Cochrane we provide some background about our organization. PMID:23980033

Bellorini, Jenny; Schilder, Anne G M; Burton, Martin J

2013-08-26

54

Evidence-Based Hand Surgery: The Role of Cochrane Reviews  

Microsoft Academic Search

A detailed literature search was performed to investigate whether the increasing importance of evidence-based hand surgery is reflected in the actual status of Cochrane reviews. Fourteen Cochrane reviews were found and evaluated. Of these, five reviews were in the field of distal radial fractures and four concerned carpal tunnel syndrome. Cochrane reviews were also found for antibiotic treatment, rehabilitation after

J. WINDOLF; G. ANTES; S. SAUERLAND; M. K. DIENER

2008-01-01

55

Use of weaning protocols for reducing duration of mechanical ventilation in critically ill adult patients: Cochrane systematic review and meta-analysis  

Microsoft Academic Search

Objective To investigate the effects of weaning protocols on the total duration of mechanical ventilation, mortality, adverse events, quality of life, weaning duration, and length of stay in the intensive care unit and hospital.Design Systematic review.Data sources Cochrane Central Register of Controlled Trials, Medline, Embase, CINAHL, LILACS, ISI Web of Science, ISI Conference Proceedings, Cambridge Scientific Abstracts, and reference lists

Bronagh Blackwood; Fiona Alderdice; Karen Burns; Chris Cardwell; Gavin Lavery; Peter O’Halloran

2011-01-01

56

PubMed searches: overview and strategies for clinicians.  

PubMed

PubMed is a biomedical and life sciences database maintained by a division of the National Library of Medicine known as the National Center for Biotechnology Information (NCBI). It is a large resource with more than 5600 journals indexed and greater than 22 million total citations. Searches conducted in PubMed provide references that are more specific for the intended topic compared with other popular search engines. Effective PubMed searches allow the clinician to remain current on the latest clinical trials, systematic reviews, and practice guidelines. PubMed continues to evolve by allowing users to create a customized experience through the My NCBI portal, new arrangements and options in search filters, and supporting scholarly projects through exportation of citations to reference managing software. Prepackaged search options available in the Clinical Queries feature also allow users to efficiently search for clinical literature. PubMed also provides information regarding the source journals themselves through the Journals in NCBI Databases link. This article provides an overview of the PubMed database's structure and features as well as strategies for conducting an effective search. PMID:23442731

Lindsey, Wesley T; Olin, Bernie R

2013-02-26

57

Identifying Diagnostic Studies in MEDLINE: Reducing the Number Needed to Read  

Microsoft Academic Search

ObjectivesThe search filters in PubMed have become a cornerstone in information retrieval in evidence-based practice. However, the filter for diagnostic studies is not fully satisfactory, because sensitive searches have low precision. The objective of this study was to construct and validate better search strategies to identify diagnostic articles recorded on MEDLINE with special emphasis on precision.DesignA comparative, retrospective analysis was

Lucas M Bachmann; Reto Coray; Pius Estermann; Gerben ter Riet

2002-01-01

58

Retrieval of diagnostic and treatment studies for clinical use through PubMed and PubMed's Clinical Queries filters  

Microsoft Academic Search

ObjectiveClinical Queries filters were developed to improve the retrieval of high-quality studies in searches on clinical matters. The study objective was to determine the yield of relevant citations and physician satisfaction while searching for diagnostic and treatment studies using the Clinical Queries page of PubMed compared with searching PubMed without these filters.Materials and methodsForty practicing physicians, presented with standardized treatment

Cynthia Lokker; R Brian Haynes; Nancy L Wilczynski; K Ann McKibbon; Stephen D Walter

2011-01-01

59

GeneView: a comprehensive semantic search engine for PubMed  

PubMed Central

Research results are primarily published in scientific literature and curation efforts cannot keep up with the rapid growth of published literature. The plethora of knowledge remains hidden in large text repositories like MEDLINE. Consequently, life scientists have to spend a great amount of time searching for specific information. The enormous ambiguity among most names of biomedical objects such as genes, chemicals and diseases often produces too large and unspecific search results. We present GeneView, a semantic search engine for biomedical knowledge. GeneView is built upon a comprehensively annotated version of PubMed abstracts and openly available PubMed Central full texts. This semi-structured representation of biomedical texts enables a number of features extending classical search engines. For instance, users may search for entities using unique database identifiers or they may rank documents by the number of specific mentions they contain. Annotation is performed by a multitude of state-of-the-art text-mining tools for recognizing mentions from 10 entity classes and for identifying protein–protein interactions. GeneView currently contains annotations for >194 million entities from 10 classes for ?21 million citations with 271?000 full text bodies. GeneView can be searched at http://bc3.informatik.hu-berlin.de/.

Thomas, Philippe; Starlinger, Johannes; Vowinkel, Alexander; Arzt, Sebastian; Leser, Ulf

2012-01-01

60

Statistical Multiplicity in Systematic Reviews of Anaesthesia Interventions: A Quantification and Comparison between Cochrane and Non-Cochrane Reviews  

PubMed Central

Background Systematic reviews with meta-analyses often contain many statistical tests. This multiplicity may increase the risk of type I error. Few attempts have been made to address the problem of statistical multiplicity in systematic reviews. Before the implications are properly considered, the size of the issue deserves clarification. Because of the emphasis on bias evaluation and because of the editorial processes involved, Cochrane reviews may contain more multiplicity than their non-Cochrane counterparts. This study measured the quantity of statistical multiplicity present in a population of systematic reviews and aimed to assess whether this quantity is different in Cochrane and non-Cochrane reviews. Methods/Principal Findings We selected all the systematic reviews published by the Cochrane Anaesthesia Review Group containing a meta-analysis and matched them with comparable non-Cochrane reviews. We counted the number of statistical tests done in each systematic review. The median number of tests overall was 10 (interquartile range (IQR) 6 to 18). The median was 12 in Cochrane and 8 in non-Cochrane reviews (difference in medians 4 (95% confidence interval (CI) 2.0–19.0). The proportion that used an assessment of risk of bias as a reason for doing extra analyses was 42% in Cochrane and 28% in non-Cochrane reviews (difference in proportions 14% (95% CI ?8 to 36). The issue of multiplicity was addressed in 6% of all the reviews. Conclusion/Significance Statistical multiplicity in systematic reviews requires attention. We found more multiplicity in Cochrane reviews than in non-Cochrane reviews. Many of the reasons for the increase in multiplicity may well represent improved methodological approaches and greater transparency, but multiplicity may also cause an increased risk of spurious conclusions. Few systematic reviews, whether Cochrane or non-Cochrane, address the issue of multiplicity.

Imberger, Georgina; Vejlby, Alexandra Damgaard; Hansen, Sara Bohnstedt; M?ller, Ann M.; Wetterslev, J?rn

2011-01-01

61

How Complementary and Alternative Medicine Practitioners Use PubMed  

PubMed Central

Background PubMed is the largest bibliographic index in the life sciences. It is freely available online and is used by professionals and the public to learn more about medical research. While primarily intended to serve researchers, PubMed provides an array of tools and services that can help a wider readership in the location, comprehension, evaluation, and utilization of medical research. Objective This study sought to establish the potential contributions made by a range of PubMed tools and services to the use of the database by complementary and alternative medicine practitioners. Methods In this study, 10 chiropractors, 7 registered massage therapists, and a homeopath (N = 18), 11 with prior research training and 7 without, were taken through a 2-hour introductory session with PubMed. The 10 PubMed tools and services considered in this study can be divided into three functions: (1) information retrieval (Boolean Search, Limits, Related Articles, Author Links, MeSH), (2) information access (Publisher Link, LinkOut, Bookshelf ), and (3) information management (History, Send To, Email Alert). Participants were introduced to between six and 10 of these tools and services. The participants were asked to provide feedback on the value of each tool or service in terms of their information needs, which was ranked as positive, positive with emphasis, negative, or indifferent. Results The participants in this study expressed an interest in the three types of PubMed tools and services (information retrieval, access, and management), with less well-regarded tools including MeSH Database and Bookshelf. In terms of their comprehension of the research, the tools and services led the participants to reflect on their understanding as well as their critical reading and use of the research. There was universal support among the participants for greater access to complete articles, beyond the approximately 15% that are currently open access. The abstracts provided by PubMed were felt to be necessary in selecting literature to read but entirely inadequate for both evaluating and learning from the research. Thus, the restrictions and fees the participants faced in accessing full-text articles were points of frustration. Conclusions The study found strong indications of PubMed’s potential value in the professional development of these complementary and alternative medicine practitioners in terms of engaging with and understanding research. It provides support for the various initiatives intended to increase access, including a recommendation that the National Library of Medicine tap into the published research that is being archived by authors in institutional archives and through other websites.

Quint-Rapoport, Mia

2007-01-01

62

Cochrane and non-Cochrane systematic reviews in leading orthodontic journals: a quality paradigm?  

PubMed

The aims of this study were to assess and compare the methodological quality of Cochrane and non-Cochrane systematic reviews (SRs) published in leading orthodontic journals and the Cochrane Database of Systematic Reviews (CDSR) using AMSTAR and to compare the prevalence of meta-analysis in both review types. A literature search was undertaken to identify SRs that consisted of hand-searching five major orthodontic journals [American Journal of Orthodontics and Dentofacial Orthopedics, Angle Orthodontist, European Journal of Orthodontics, Journal of Orthodontics and Orthodontics and Craniofacial Research (February 2002 to July 2011)] and the Cochrane Database of Systematic Reviews from January 2000 to July 2011. Methodological quality of the included reviews was gauged using the AMSTAR tool involving 11 key methodological criteria with a score of 0 or 1 given for each criterion. A cumulative grade was given for the paper overall (0-11); an overall score of 4 or less represented poor methodological quality, 5-8 was considered fair and 9 or greater was deemed to be good. In total, 109 SRs were identified in the five major journals and on the CDSR. Of these, 26 (23.9%) were in the CDSR. The mean overall AMSTAR score was 6.2 with 21.1% of reviews satisfying 9 or more of the 11 criteria; a similar prevalence of poor reviews (22%) was also noted. Multiple linear regression indicated that reviews published in the CDSR (P < 0.01); and involving meta-analysis (? = 0.50, 95% confidence interval 0.72, 2.07, P < 0.001) showed greater concordance with AMSTAR. PMID:22510325

Fleming, Padhraig S; Seehra, Jadbinder; Polychronopoulou, Argy; Fedorowicz, Zbys; Pandis, Nikolaos

2012-04-16

63

MedlinePlus.gov on Twitter  

MedlinePLUS

... page please turn Javascript on. MedlinePlus.gov on Twitter Past Issues / Fall 2009 Table of Contents You can now follow MedlinePlus.gov on Twitter: twitter.com/medlineplus4you The medlineplus4you Twitter feed provides ...

64

MedlinePlus FAQ: Spelling Assistance  

MedlinePLUS

... sure how to spell the name of my disease/medical condition. How do I find it in MedlinePlus? To ... checker suggests other words to replace it. The Medical Dictionary also ... and conditions on many MedlinePlus health topic pages. Return to ...

65

MedlinePlus Connect: Web Application  

MedlinePLUS

MedlinePlus Connect: Web Application To use the sharing features on this page, please enable JavaScript. MedlinePlus Connect is available as a ... please see our guidelines and instructions on linking. Web Application Overview The API for the Web application ...

66

Visit the new MedlinePlus | NIH MedlinePlus the Magazine  

MedlinePLUS

... this page please turn Javascript on. Visit the new MedlinePlus Past Issues / Fall 2010 Table of Contents ... trusted, up-to-date medical information Visit the new MedlinePlus From the top medical experts at the ...

67

Acupuncture for pain: An overview of Cochrane reviews  

Microsoft Academic Search

Objective  Cochrane reviews have the reputation for being more transparent and rigorous than other reviews. The aim of this overview\\u000a was to evaluate and summarize Cochrane reviews of acupuncture for the treatment of any type of pain.\\u000a \\u000a \\u000a \\u000a \\u000a Methods  We searched the Cochrane Database and evaluated the Cochrane reviews that were concerned specifically with the effectiveness\\u000a of acupuncture for pain. Data were extracted

Myeong Soo Lee; Edzard Ernst

2011-01-01

68

Telehealthcare for chronic obstructive pulmonary disease: Cochrane Review and meta-analysis  

PubMed Central

Background Chronic obstructive pulmonary disease (COPD) is common. Telehealthcare, involving personalised health care over a distance, is seen as having the potential to improve care for people with COPD. Aim To systematically review the effectiveness of telehealthcare interventions in COPD to improve clinical and process outcomes. Design and setting Cochrane Systematic Review of randomised controlled trials. Methods The study involved searching the Cochrane Airways Group Register of Trials, which is derived from the Cochrane Central Register of Controlled Trials, MEDLINE®, embase™, and CINAHL®, as well as searching registers of ongoing and unpublished trials. Randomised controlled trials comparing a telehealthcare intervention with a control intervention in people with a clinical diagnosis of COPD were identified. The main outcomes of interest were quality of life and risk of emergency department visit, hospitalisation, and death. Two authors independently selected trials for inclusion and extracted data. Study quality was assessed using the Cochrane Collaboration’s risk of bias method. Meta-analysis was undertaken using fixed effect and/or random effects modelling. Results Ten randomised controlled trials were included. Telehealthcare did not improve COPD quality of life: mean difference –6.57 (95% confidence interval [CI] = –13.62 to 0.48). However, there was a significant reduction in the odds ratios (ORs) of emergency department attendance (OR = 0.27; 95% CI = 0.11 to 0.66) and hospitalisation (OR = 0.46; 95% CI = 0.33 to 0.65). There was a non-significant change in the OR of death (OR = 1.05; 95% CI = 0.63 to 1.75). Conclusion In COPD, telehealthcare interventions can significantly reduce the risk of emergency department attendance and hospitalisation, but has little effect on the risk of death.

McLean, Susannah; Nurmatov, Ulugbek; Liu, Joseph LY; Pagliari, Claudia; Car, Josip; Sheikh, Aziz

2012-01-01

69

Spelling correction in the PubMed search engine  

Microsoft Academic Search

It is known that users of internet search engines often enter queries with misspellings in one or more search terms. Several web search engines make suggestions for correcting misspelled words, but the methods used are proprietary and unpublished to our knowledge. Here we describe the methodology we have developed to perform spelling correction for the PubMed search engine. Our approach

W. John Wilbur; Won Kim; Natalie Xie

2006-01-01

70

MELVYL MEDLINE: a library services perspective.  

PubMed

The MELVYL MEDLINE project resulted in the addition of a full five-year subset of MEDLINE to the University of California's (UC) MELVYL online union catalog. As one of the nation's largest MEDLINE end-user searching systems, MELVYL MEDLINE provides online bibliographic access to the biomedical journal literature for all UC personnel at over seventy library sites or by remote access. This paper summarizes the project's accomplishments, reports MELVYL MEDLINE use and its impact on library services, and provides insights for other end-user search systems. The project serves as a model for adding databases to the MELVYL catalog and demonstrates the potential for use by other disciplines of a specialized database when readily accessible. Evaluation results report high user satisfaction and high usage. However, many advanced searching features of the interface are little used by searchers. Effects on library services include marked increases in reference transactions and interlibrary loans, with significant declines in mediated search services. Future MELVYL MEDLINE enhancements include matching search retrievals to journal locations, linkage to an online document delivery system, and consideration of building a superset of databases by combining MELVYL MEDLINE with citations from another database in the MELVYL catalog. PMID:1884086

Horres, M M; Starr, S S; Renford, B L

1991-07-01

71

MELVYL MEDLINE: a library services perspective.  

PubMed Central

The MELVYL MEDLINE project resulted in the addition of a full five-year subset of MEDLINE to the University of California's (UC) MELVYL online union catalog. As one of the nation's largest MEDLINE end-user searching systems, MELVYL MEDLINE provides online bibliographic access to the biomedical journal literature for all UC personnel at over seventy library sites or by remote access. This paper summarizes the project's accomplishments, reports MELVYL MEDLINE use and its impact on library services, and provides insights for other end-user search systems. The project serves as a model for adding databases to the MELVYL catalog and demonstrates the potential for use by other disciplines of a specialized database when readily accessible. Evaluation results report high user satisfaction and high usage. However, many advanced searching features of the interface are little used by searchers. Effects on library services include marked increases in reference transactions and interlibrary loans, with significant declines in mediated search services. Future MELVYL MEDLINE enhancements include matching search retrievals to journal locations, linkage to an online document delivery system, and consideration of building a superset of databases by combining MELVYL MEDLINE with citations from another database in the MELVYL catalog.

Horres, M M; Starr, S S; Renford, B L

1991-01-01

72

Extracts from The Cochrane Library: Sublingual immunotherapy for allergic rhinitis.  

PubMed

The "Cochrane Corner" is a quarterly section in the Journal that highlights systematic reviews relevant to otolaryngology-head and neck surgery, with invited commentary to aid clinical decision making. This installment features an updated Cochrane Review titled "Sublingual Immunotherapy for Allergic Rhinitis," which strengthens conclusions of the original 2003 review that sublingual immunotherapy is a safe and effective treatment strategy. PMID:21493409

Burton, Martin J; Krouse, John H; Rosenfeld, Richard M

2011-01-24

73

NIH MedlinePlus Magazine Summer 2013  

MedlinePLUS

... believes skin cancer rates will increase among U.S. soldiers returning from recent wars. Dr. Long says (and ... MedlinePlus magazine reports the cost of caring for Americans with dementia was between $159 to $215 billion ...

74

Back Cover: NIH MedlinePlus Salud  

MedlinePLUS

... Bar Home Current Issue Past Issues NIH MedlinePlus Salud Past Issues / Winter 2009 Table of Contents For ... this page please turn Javascript on. ¡A su salud! Los Institutos Nacionales de la Salud (NIH, por ...

75

MEDLINE services to the developing countries.  

PubMed Central

Supplying MEDLINE services to a widely dispersed user population in the developing countries creates numerous problems not encountered by other MEDLINE centres. The inability to interact with the user complicates system promotion and makes search formulation sometimes a gamble. Nevertheless, an evaluation survey has shown high user satisfaction. Of great concern is the still inadequate solution of document delivery. Near-term objectives are the broadening of geographic coverage and the integration of search processing with supporting hard copy supply.

Weitzel, R

1976-01-01

76

MedlinePlus 2010 User Survey Results: How did you learn of the MedlinePlus web site?  

MedlinePLUS

... Next How did you learn of the MedlinePlus web site? Responses: Web search engine (Yahoo!, Google, AOL, etc.) MedlinePlus users ... MedlinePlus en español users 75% Link from another Web site MedlinePlus users 11% MedlinePlus en español users ...

77

Evidence-Based Practice: The Cochrane Collaboration, and Occupational Therapy.  

ERIC Educational Resources Information Center

The Cochrane Collaboration is an international project to locate, review, and disseminate information on available randomized controlled trials of health care interventions. Occupational therapists can use it to learn about best practices and evaluate research relevant to their clients. (SK)

Hayes, Robyn; McGrath, John

1998-01-01

78

MEDLINE: the options for health professionals.  

PubMed Central

The bibliographic database MEDLINE, produced by the National Library of Medicine (NLM), is a computerized index to the world's biomedical literature. The database can be searched back to 1966 and contains 6.8 million records. The various means of access are divided, for the purposes of this article, into three categories: logging onto a remote host computer by telephone and modem or by the Internet; subscribing to part or all of the database on compact disc (CD-ROM); and leasing the data on a transport medium such as magnetic tape or CDs for loading on a local host computer. Decisions about which method is preferable in a given situation depend on cost, availability of hardware and software, local expertise, and the size of the intended user population. Trends include increased access to the Internet by health professionals, increased network speed, links from MEDLINE records to full-text databases or online journals, and integration of MEDLINE into wider health information systems.

Wood, E H

1994-01-01

79

Making PubMed searching simple: learning to retrieve medical literature through interactive problem solving.  

PubMed

Searching the literature has a direct, beneficial influence on patient care. The amount of medical scientific information has increased to a great extent, while the development of networking technologies has broadened access to online databases. Successful searches depend upon understanding technical librarianship concepts and the skills for mastering searching interfaces. From a problem-oriented approach, concepts like MEDLINE coverage, PubMed resources, Boolean logic, search strategies, and Web sources for full-text articles are introduced along seven online situations: locating a specific publication, answering a complex clinical question, finding information on a general subject, finding publications by a particular author, finding publications in a particular language, finding a specific publication type, and locating the full-text document. Oncologists should face the challenge of performing their own searches. Specific knowledge is mandatory to avoid frustrating, time-consuming work. The objective of this work is to present concepts, strategies, and skills required for medical literature retrieval, easing the incorporation of new and welcomed practices. PMID:16549808

Vincent, Beatriz; Vincent, Maurice; Ferreira, Carlos Gil

2006-03-01

80

PubMed related articles: a probabilistic topic-based model for content similarity  

PubMed Central

Background We present a probabilistic topic-based model for content similarity called pmra that underlies the related article search feature in PubMed. Whether or not a document is about a particular topic is computed from term frequencies, modeled as Poisson distributions. Unlike previous probabilistic retrieval models, we do not attempt to estimate relevance–but rather our focus is "relatedness", the probability that a user would want to examine a particular document given known interest in another. We also describe a novel technique for estimating parameters that does not require human relevance judgments; instead, the process is based on the existence of MeSH ® in MEDLINE ®. Results The pmra retrieval model was compared against bm25, a competitive probabilistic model that shares theoretical similarities. Experiments using the test collection from the TREC 2005 genomics track shows a small but statistically significant improvement of pmra over bm25 in terms of precision. Conclusion Our experiments suggest that the pmra model provides an effective ranking algorithm for related article search.

Lin, Jimmy; Wilbur, W John

2007-01-01

81

[Taehan Kan Hakhoe Chi (The Korean Journal of Hepatology) and Index Medicus (Medline/PubMed)].  

PubMed

It is our great pleasure to announce that the Taehan Kan Hakhoe Chi (The Korean Journal of Hepatology) was approved for listing, from 2002, in the Index Medicus, Medline/PubMed of the National Library of Medicine, NIH of USA. Herein, I review the searching tools employing a Medical Subject Heading (MeSH) such as liver disease and liver neoplasm or an author index for this Journal in the PubMed at a website. Of course, The Korean Journal of Hepatology should be continually striving to be upgraded. Dream comes true. PMID:12657828

Lee, Dong Hoo

2003-03-01

82

Comparison of the efficacy of three PubMed search filters in finding randomized controlled trials to answer clinical questions.  

PubMed

Objective? The aim of this study was to compare the performance of three search methods in the retrieval of relevant clinical trials from PubMed to answer specific clinical questions. Methods? Included studies of a sample of 100 Cochrane reviews which recorded in PubMed were considered as the reference standard. The search queries were formulated based on the systematic review titles. Precision, recall and number of retrieved records for limiting the results to clinical trial publication type, and using sensitive and specific clinical queries filters were compared. The number of keywords, presence of specific names of intervention and syndrome in the search keywords were used in a model to predict the recalls and precisions. Results? The Clinical queries-sensitive search strategy retrieved the largest number of records (33) and had the highest recall (41.6%) and lowest precision (4.8%). The presence of specific intervention name was the only significant predictor of all recalls and precisions (P?=?0.016). Conclusion? The recall and precision of combination of simple clinical search queries and methodological search filters to find clinical trials in various subjects were considerably low. The limit field strategy yielded in higher precision and fewer retrieved records and approximately similar recall, compared with the clinical queries-sensitive strategy. Presence of specific intervention name in the search keywords increased both recall and precision. PMID:20846321

Yousefi-Nooraie, Reza; Irani, Shirin; Mortaz-Hedjri, Soroush; Shakiba, Behnam

2010-09-16

83

End User Searching of Medline. Final Report.  

ERIC Educational Resources Information Center

One hundred sixty-one MEDLINE searches conducted by third year medical students were analyzed and evaluated to determine which search behaviors were used, whether those individual moves are effective, and whether there is a relationship between specific search behaviors and the effectiveness of the search strategy as a whole. The typical search…

Wildemuth, Barbara M.; Moore, Margaret E.

84

Open Biomedical Ontology-based Medline exploration  

PubMed Central

Background Effective Medline database exploration is critical for the understanding of high throughput experimental results and the development of novel hypotheses about the mechanisms underlying the targeted biological processes. While existing solutions enhance Medline exploration through different approaches such as document clustering, network presentations of underlying conceptual relationships and the mapping of search results to MeSH and Gene Ontology trees, we believe the use of multiple ontologies from the Open Biomedical Ontology can greatly help researchers to explore literature from different perspectives as well as to quickly locate the most relevant Medline records for further investigation. Results We developed an ontology-based interactive Medline exploration solution called PubOnto to enable the interactive exploration and filtering of search results through the use of multiple ontologies from the OBO foundry. The PubOnto program is a rich internet application based on the FLEX platform. It contains a number of interactive tools, visualization capabilities, an open service architecture, and a customizable user interface. It is freely accessible at: .

Xuan, Weijian; Dai, Manhong; Mirel, Barbara; Song, Jean; Athey, Brian; Watson, Stanley J; Meng, Fan

2009-01-01

85

Best Available Evidence in Cochrane Reviews on Herbal Medicine?  

PubMed Central

Cochrane reviews are considered by many to be the “gold standard” or the final word in medical conversation on a topic. We explored the eleven most relevant Cochrane reviews on herbal medicine and identified that frequently herbal medicines in the included studies had not been sufficiently well characterised. If data on the effects of the plant parts are unavailable, effects of co-active ingredients need to be considered and the plausibility of the study medications for the specific indications discussed. Effect sizes calculated from exploratory studies would be best used to determine the sample sizes required for future confirmatory studies, rather than as definitive reports of intervention effects. Reviews should be comprehensive, including discussion of putative adverse events and possible drug interactions. We suggest that the guidelines for preparing Cochrane reviews be revised and offer assistance in this task.

Davidson, Elyad; Vlachojannis, Julia; Cameron, Melainie; Chrubasik, Sigrun

2013-01-01

86

Extracting noun phrases for all of MEDLINE.  

PubMed Central

A natural language parser that could extract noun phrases for all medical texts would be of great utility in analyzing content for information retrieval. We discuss the extraction of noun phrases from MEDLINE, using a general parser not tuned specifically for any medical domain. The noun phrase extractor is made up of three modules: tokenization; part-of-speech tagging; noun phrase identification. Using our program, we extracted noun phrases from the entire MEDLINE collection, encompassing 9.3 million abstracts. Over 270 million noun phrases were generated, of which 45 million were unique. The quality of these phrases was evaluated by examining all phrases from a sample collection of abstracts. The precision and recall of the phrases from our general parser compared favorably with those from three other parsers we had previously evaluated. We are continuing to improve our parser and evaluate our claim that a generic parser can effectively extract all the different phrases across the entire medical literature.

Bennett, N. A.; He, Q.; Powell, K.; Schatz, B. R.

1999-01-01

87

Evaluating Relevance Ranking Strategies for MEDLINE Retrieval  

PubMed Central

This paper evaluates the retrieval effectiveness of relevance ranking strategies on a collection of 55 queries and about 160,000 MEDLINE® citations used in the 2006 and 2007 Text Retrieval Conference (TREC) Genomics Tracks. The authors study two relevance ranking strategies: term frequency–inverse document frequency (TF-IDF) weighting and sentence-level co-occurrence, and examine their ability to rank retrieved MEDLINE documents given user queries. Furthermore, the authors use the reverse chronological order—PubMed's default display option—as a baseline for comparison. Retrieval effectiveness is assessed using both mean average precision and mean rank precision. Experimental results show that retrievals based on the two strategies had improved performance over the baseline performance, and that TF-IDF weighting is more effective in retrieving relevant documents based on the comparison between the two strategies.

Lu, Zhiyong; Kim, Won; Wilbur, W. John

2009-01-01

88

Parenting Training for Intellectually Disabled Parents: A Cochrane Systematic Review  

ERIC Educational Resources Information Center

Objectives: This article presents a Cochrane/Campbell systematic review of the evidence on the effect of parent training to support the parenting of parents with intellectual disabilities. Method: Randomized controlled trials (RCTs) comparing parent training interventions for parents with intellectual disability with usual care or with a control…

Coren, Esther; Thomae, Manuela; Hutchfield, Jemeela

2011-01-01

89

Lake Cochrane Perimeter Road-Sediment Traps Project.  

National Technical Information Service (NTIS)

Lake Cochrane is one of the few deep high quality prairie lakes in northeastern South Dakota. Local interests tried unsuccessfully for several years to develop measures to reduce sediment inflow. The proposal to develop sediment traps as a part of the lak...

J. L. Siegel

1979-01-01

90

Lake Cochrane Perimeter Road-Sediment Traps Project.  

National Technical Information Service (NTIS)

Lake Cochrane is one of the few deep high quality prairie lakes in northeastern South Dakota. Local interests tried unsuccessfully for several years to reduce sediment inflow. The proposal to develop sediment traps as a part of the lake's perimeter road s...

J. L. Siegel

1979-01-01

91

Pitfalls in the Application of the Cochrane-Orcutt Technique.  

National Technical Information Service (NTIS)

The paper highlights a potential danger in the use of the Cochrane-Orcutt technique to remove first-order autocorrelation. The problem arises through the possible existence of multiple minima (sum of squared residuals), with the technique locating a local...

L. T. Oxley C. J. Roberts

1981-01-01

92

Connecting the Dots between PubMed Abstracts  

PubMed Central

Background There are now a multitude of articles published in a diversity of journals providing information about genes, proteins, pathways, and diseases. Each article investigates subsets of a biological process, but to gain insight into the functioning of a system as a whole, we must integrate information from multiple publications. Particularly, unraveling relationships between extra-cellular inputs and downstream molecular response mechanisms requires integrating conclusions from diverse publications. Methodology We present an automated approach to biological knowledge discovery from PubMed abstracts, suitable for “connecting the dots” across the literature. We describe a storytelling algorithm that, given a start and end publication, typically with little or no overlap in content, identifies a chain of intermediate publications from one to the other, such that neighboring publications have significant content similarity. The quality of discovered stories is measured using local criteria such as the size of supporting neighborhoods for each link and the strength of individual links connecting publications, as well as global metrics of dispersion. To ensure that the story stays coherent as it meanders from one publication to another, we demonstrate the design of novel coherence and overlap filters for use as post-processing steps. Conclusions We demonstrate the application of our storytelling algorithm to three case studies: i) a many-one study exploring relationships between multiple cellular inputs and a molecule responsible for cell-fate decisions, ii) a many-many study exploring the relationships between multiple cytokines and multiple downstream transcription factors, and iii) a one-to-one study to showcase the ability to recover a cancer related association, viz. the Warburg effect, from past literature. The storytelling pipeline helps narrow down a scientist's focus from several hundreds of thousands of relevant documents to only around a hundred stories. We argue that our approach can serve as a valuable discovery aid for hypothesis generation and connection exploration in large unstructured biological knowledge bases.

Hossain, M. Shahriar; Gresock, Joseph; Edmonds, Yvette; Helm, Richard; Potts, Malcolm; Ramakrishnan, Naren

2012-01-01

93

MedlinePlus FAQ: Listing Your Web Site  

MedlinePLUS

... Supplements Videos & Cool Tools ESPAÑOL Question: How do Web sites get listed in MedlinePlus? To use the ... authoritative resources. MedlinePlus uses quality guidelines to evaluate Web sites. We try to ensure that the information ...

94

Txt2MEDLINE: Text-Messaging Access to MEDLINE/PubMed  

PubMed Central

We developed a text messaging system for processing incoming Short Message Service (SMS) queries, retrieving medical journal citations from MEDLINE/PubMed and sending them back to the user in the text message format. A database of medical terminology abbreviations and acronyms was developed to reduce the size of text in journal citations and abstracts because of the 160-character per message limit of text messages. Queries may be sent as full-length terms or abbreviations. An algorithm transforms the citations into the SMS format. An abbreviated TBL (the bottom-line) summary instead of the full abstract is sent to the mobile device to shorten the resulting text. The system decreases citation size by 77.5±7.9%. Txt2MEDLINE provides physicians and healthcare personnel another rapid and convenient method for searching MEDLINE/PubMed through wireless mobile devices. It is accessible from any location worldwide where GSM wireless service is available.

Fontelo, Paul; Liu, Fang; Muin, Michael; Tolentino, Herman; Ackerman, Michael

2006-01-01

95

Development of biomedical publications on ametropia research in PubMed from 1845 to 2010: a bibliometric analysis  

PubMed Central

AIM We have carried out a bibliometric analysis on the development of ametropia literature to determine its growth rule and tendency, and to provide the basis for the problems related to ametropia research. METHODS Literatures that contained the descriptors of ametropia in title or paper published before Nov. 10, 2010 in PubMed databases (www.ncbi.nlm.nih.gov/Pubmed) were selected. As bibliometric indicators of ametropia, biomedical journals referring to ophthalmology by ISSN were calculated. The principal bibliometric indicators: Price's and Bradford's laws were applied on the increase or dispersion of scientific literature, the participation index of languages and the journals. By means of manual coding, literatures were classified according to documents study and statistical analysis. RESULTS The literatures cited in ametropia, astigmatism, myopia and hypermetropia had accumulated to 26475, which consists of Review (n=1560), Randomized Controlled Trial (n=776), Practice Guideline (n=10), Meta-Analysis (n=23), Letter (n=1222), Editorial (n=328), Clinical Trial (n=1726) and Others (n=20830), and Humans (n=23073), Animals(n=1434) and others (n=1968). 1136 literatures were included in PubMed Central, 22384 in MEDLINE and 2955 in others. The ametropia literatures rose every 5 years which of the ametropia-year cumulated amount of the literatures had three periods: before 1900, slowly increasing from 1901 to 1950, rapidly rising from 1951 to 2010 (increased approximate exponentiation exponent). Sixty kinds of languages listed in PubMed databases, of which English is dominant for aborting to ametropia research documents before 2010 (77.32%, 20471/26475). The document languages of top eight account for 95.58% (English, German, French, Japanese, Russian, Italian, Spanish, Chinese), and others for 4.42% (1171/26475). The SCI database includes 48 ophthalmologic journals and the impact factor of 39 journals is ?1 on Thomson-Reuters in 2010. Of 48 ophthalmologic journals, there were 14785 documents (55.85%) of ametropia, astigmatism, myopia, and hypermetropia. Others were without exception. CONCLUSION The bibliometric analysis results show that ametropia literature are increased progressively, approximate exponentiation exponent during 1951-2010. In addition, ametropia research has become more popular since nearly half century.

Xu, Chang-Tai; Li, Shan-Qu; Lu, Yong-Gang; Pan, Bo-Rong

2011-01-01

96

MedlinePlus 2011 User Survey Results: What best describes your role in visiting MedlinePlus during this session?  

MedlinePLUS

... features on this page, please enable JavaScript. 2011 User Survey Results: Slide Index | Previous | Next What best ... Patient with a specific disease or condition MedlinePlus users 33% MedlinePlus en español users 24% Health care ...

97

MedlinePlus 2011 User Survey Results: What is your primary reason for visiting the MedlinePlus site today?  

MedlinePLUS

... features on this page, please enable JavaScript. 2011 User Survey Results: Slide Index | Previous | Next What is ... a specific disease, condition, diagnosis, or treatment MedlinePlus users 54% MedlinePlus en español users 29% Find info ...

98

Medline-based bibliometric analysis of gastroenterology journals between 2001 and 2007  

PubMed Central

AIM: To analyze the MEDLINE-indexed publications in gastroenterology specialty journals from 2001 to 2007. Special attention was paid to specific types of articles, the number of publications for individual authors and the author count in each journal. METHODS: The bibliographic entries of papers belonging to journals listed under the subject heading of “gastroenterology” were downloaded from MEDLINE on the PubMed web site. The analysis was limited to journal articles published between January 1, 2001 and December 31, 2007. The analytical dimensions of an article included journal, publication year, publication type, and author name (the last name and initials). RESULTS: According to MEDLINE, 81 561 articles were published in 91 gastroenterology journals from 2001 to 2007. The number of articles increased from 9447 in 2001 to 13 340 in 2007. Only 12 journals had more than 2000 articles indexed in MEDLINE. The “World Journal of Gastroenterology” had the largest number of publications (5684 articles), followed by “Hepato-Gastroenterology” (3036) and “Gastrointestinal Endoscopy” (3005). Of all the articles published, reviews accounted for 17.2% and case reports for 15.4%. Only 3739 randomized controlled trials (4.6% of all articles) were published and their annual number increased from 442 in 2001 to 572 in 2007. Among 141 741 author names appearing in the articles of gastroenterology journals, 92 429 had published only in one journal, 22 585 in two journals, 9996 in three journals, and 16 731 in more than three journals. The “World Journal of Gastroenterology” had the greatest number of authors (17 838), followed by “Gastroenterology” (12 770), “Digestive Diseases and Sciences” (11 395), “American Journal of Gastroenterology” (10 889), and “Hepatology” (10 588). CONCLUSION: Global gastroenterology publications displayed a continuous growth in the new millennium. The change was most striking in certain journals. Regular bibliometric analyses on the trends and specific topics would help researchers publish more efficiently and allow editors to adjust the policy more accurately.

Chou, Li-Fang

2009-01-01

99

A Cochrane systematic review finds no evidence to support the use of antibiotics for pain relief in irreversible pulpitis.  

PubMed

The Cochrane Systematic Review promotes evidence-based outcomes studies. The review summarized here was conducted in an attempt to achieve reliable evidence concerning the effectiveness, or otherwise, of prescribing antibiotics for patients having irreversible pulpitis. A competent search strategy was developed and used across several databases including MEDLINE to identify randomized controlled trials for inclusion. Assessment of methodological quality was based on criteria defined by The Cochrane Collaboration. Clinical outcome, expressed in terms of pain relief, was examined. There was a relative dearth of research providing a high level of evidence. Only one methodologically sound trial was found that compared pain relief with systemic antibiotic/analgesic treatment against a placebo/analgesic combination during the acute preoperative phase of irreversible pulpitis. Although the selected study used a relatively small, low-powered sample, it did provide some evidence that there is no significant difference in pain relief for patients with untreated irreversible pulpitis who received antibiotics versus those who did not. These findings increase the rationale to investigate the teaching of safe and effective antibiotic prescribing in endodontics and to advance the development of appropriate evidence-based clinical guidelines. PMID:16427452

Keenan, James V; Farman, Allan G; Fedorowicz, Zbigniew; Newton, Jonathan T

2006-02-01

100

Cochrane Systematic Reviews of Chinese Herbal Medicines: An Overview  

PubMed Central

Objectives Our study had two objectives: a) to systematically identify all existing systematic reviews of Chinese herbal medicines (CHM) published in Cochrane Library; b) to assess the methodological quality of included reviews. Methodology/Principal Findings We performed a systematic search of the Cochrane Database of Systematic Reviews (CDSR, Issue 5, 2010) to identify all reviews of CHM. A total of fifty-eight reviews were eligible for our study. Twenty-one of the included reviews had at least one Traditional Chinese Medicine (TCM) practitioner as its co-author. 7 reviews didn't include any primary study, the remaining reviews (n?=?51) included a median of 9 studies and 936 participants. 50% of reviews were last assessed as up-to-date prior to 2008. The questions addressed by 39 reviews were broad in scope, in which 9 reviews combined studies with different herbal medicines. For OQAQ, the mean of overall quality score (item 10) was 5.05 (95% CI; 4.58-5.52). All reviews assessed the methodological quality of primary studies, 16% of included primary studies used adequate sequence generation and 7% used adequate allocation concealment. Of the 51 nonempty reviews, 23 reviews were reported as being inconclusive, while 27 concluded that there might be benefit of CHM, which was limited by the poor quality or inadequate quantity of included studies. 58 reviews reported searching a median of seven electronic databases, while 10 reviews did not search any Chinese database. Conclusions Now CDSR has included large numbers of CHM reviews, our study identified some areas which could be improved, such as almost half of included reviews did not have the participation of TCM practitioners and were not up-to-date according to Cochrane criteria, some reviews pooled the results of different herbal medicines and ignored the searching of Chinese databases.

Hu, Jing; Zhang, Junhua; Zhao, Wei; Zhang, Yongling; Zhang, Li; Shang, Hongcai

2011-01-01

101

Mental health publications from the Arab world cited in PubMed, 1987  

Microsoft Academic Search

The study aimed to identify mental health publications in Arab countries cited in PubMed from 1987 to 2002 and to analyse the year of publication, journal and field of research, specifically for child and adolescent mental health studies. A PubMed search was performed for all mental health publications followed by an analysis of child and adolescent mental health citations. The

M. M. Afifi

2005-01-01

102

Screening for prostate cancer: A Cochrane systematic review  

Microsoft Academic Search

Objectives  The objective of this systematic review was to determine whether screening for prostate cancer reduces prostate cancer mortality.\\u000a \\u000a \\u000a \\u000a Methods  A systematic search for randomised controlled trials was conducted through electronic scientific databases and a specialist\\u000a register of the Cochrane Prostatic Diseases and Urologic Cancers Group. Manual searching of specific journals was also conducted.\\u000a Two authors independently reviewed studies that met the

Dragan Ilic; Denise O’Connor; Sally Green; Timothy Wilt

2007-01-01

103

2. ALABAMA, PICKENS, CO., COCHRANE HIGHWAY BRIDGE 1.5 miles N. ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. ALABAMA, PICKENS, CO., COCHRANE HIGHWAY BRIDGE 1.5 miles N. from Cochrane on Ala. route 17. Aerial view of Milner bridge, from SE. David J. Kaminsky, Architecturl Photography, Atlanta Ga. Aug 1978. - Bridges of the Upper Tombigbee River Valley, Cochrane, Pickens County, AL

104

5. ALABAMA, PICKENS CO., COCHRANE COLLAPSED RAILROAD BRIDGE 1.5 miles ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. ALABAMA, PICKENS CO., COCHRANE COLLAPSED RAILROAD BRIDGE 1.5 miles N. from Cochrane on Ala. route 17. Copy of photo by Jack Donnell, Columbus, Ms., after bridge collapsed in 1973. Shows broken turn span and overturned center pier. Sarcone Photography, Columbus, Ms. Sep 1978. - Bridges of the Upper Tombigbee River Valley, Cochrane, Pickens County, AL

105

1. ALABAMA, PICKENS CO., COCHRANE HIGHWAY BRIDGE 1.5 miles N. ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. ALABAMA, PICKENS CO., COCHRANE HIGHWAY BRIDGE 1.5 miles N. from Cochrane on Ala. route 17 Aerial view of Milner bridge, from SW. David J. Kaminsky, Architectural Photography, Atlanta Ga. Aug 1978. - Bridges of the Upper Tombigbee River Valley, Cochrane, Pickens County, AL

106

School as Parkland: Re-Storying the Story of Cochrane School  

ERIC Educational Resources Information Center

The narrative inquiry reported in this study offers a partial view of Cochrane Academy's nuanced landscape. This article elaborates a theoretical frame, then uses different story perspectives to survey Cochrane's professional knowledge landscape over time. It relates what currently is Cochrane Academy to parkland landscape, and it discusses the…

Craig, Cheryl J.

2007-01-01

107

4. ALABAMA, PICKENS CO., COCHRANE COLLAPSED RAILROAD BRIDGE 1.5 miles ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. ALABAMA, PICKENS CO., COCHRANE COLLAPSED RAILROAD BRIDGE 1.5 miles N. from Cochrane on Ala. route 17. Western half of collapsed Alabama, Tenn. & Northern RR. Bridge Jack Donnell, Columbus, Ms., photographer, 1973. Copy by Sarcone Photography, Columbs, Ms Sep 1978. - Bridges of the Upper Tombigbee River Valley, Cochrane, Pickens County, AL

108

3. ALABAMA, PICKENS CO., COCHRANE RAILROAD BRIDGE AND FERRY 1.5 ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. ALABAMA, PICKENS CO., COCHRANE RAILROAD BRIDGE AND FERRY 1.5 miles N. from Cochrane on Ala. route 17. Copy of photo by Jack Donnell, Columbus, Ms., 1927. West ferry landing ferry barge, andcar in foreground. Alabama, Tennessee & Northern (later Frisco) RR bridge in background. Sarcone Photography, Columbus, Ms. Sep 1978. - Bridges of the Upper Tombigbee River Valley, Cochrane, Pickens County, AL

109

6. ALABAMA, PICKENS CO., COCHRANE RAILROAD BRIDGE 1.5 miles N. ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. ALABAMA, PICKENS CO., COCHRANE RAILROAD BRIDGE 1.5 miles N. from Cochrane on Ala. route 17 Copy of photo by Jack Donnell, Columbus, Ms., 192. Shows center turn span and part of one fixed span. Sarcone Photography, Columbus, Ms. Sep 1978. - Bridges of the Upper Tombigbee River Valley, Cochrane, Pickens County, AL

110

MedlinePlus en Español and Spanish-speakers.  

PubMed

We evaluated the access of MedlinePlus in Spanish-speaking countries from 2000 to 2006. There is a progressively increasing usage of MedlinePlus by Spanish-speakers enhanced by the introduction of MedlinePlus en español. This high use reflects the active role of patients as consumers of health information seen worldwide and illustrates the importance of developing trustworthy health Websites for consumers in their native language. PMID:18694126

Leon, Sergio A; Fontelo, Paul

2007-10-11

111

General health checks in adults for reducing morbidity and mortality from disease: Cochrane systematic review and meta-analysis  

PubMed Central

Objectives To quantify the benefits and harms of general health checks in adults with an emphasis on patient-relevant outcomes such as morbidity and mortality rather than on surrogate outcomes. Design Cochrane systematic review and meta-analysis of randomised trials. For mortality, we analysed the results with random effects meta-analysis, and for other outcomes we did a qualitative synthesis as meta-analysis was not feasible. Data sources Medline, EMBASE, Healthstar, Cochrane Library, Cochrane Central Register of Controlled Trials, CINAHL, EPOC register, ClinicalTrials.gov, and WHO ICTRP, supplemented by manual searches of reference lists of included studies, citation tracking (Web of Knowledge), and contacts with trialists. Selection criteria Randomised trials comparing health checks with no health checks in adult populations unselected for disease or risk factors. Health checks defined as screening general populations for more than one disease or risk factor in more than one organ system. We did not include geriatric trials. Data extraction Two observers independently assessed eligibility, extracted data, and assessed the risk of bias. We contacted authors for additional outcomes or trial details when necessary. Results We identified 16 trials, 14 of which had available outcome data (182?880 participants). Nine trials provided data on total mortality (11?940 deaths), and they gave a risk ratio of 0.99 (95% confidence interval 0.95 to 1.03). Eight trials provided data on cardiovascular mortality (4567 deaths), risk ratio 1.03 (0.91 to 1.17), and eight on cancer mortality (3663 deaths), risk ratio 1.01 (0.92 to 1.12). Subgroup and sensitivity analyses did not alter these findings. We did not find beneficial effects of general health checks on morbidity, hospitalisation, disability, worry, additional physician visits, or absence from work, but not all trials reported on these outcomes. One trial found that health checks led to a 20% increase in the total number of new diagnoses per participant over six years compared with the control group and an increased number of people with self reported chronic conditions, and one trial found an increased prevalence of hypertension and hypercholesterolaemia. Two out of four trials found an increased use of antihypertensives. Two out of four trials found small beneficial effects on self reported health, which could be due to bias. Conclusions General health checks did not reduce morbidity or mortality, neither overall nor for cardiovascular or cancer causes, although they increased the number of new diagnoses. Important harmful outcomes were often not studied or reported. Systematic review registration Cochrane Library, doi:10.1002/14651858.CD009009.

2012-01-01

112

Relemed: sentence-level search engine with relevance score for the MEDLINE database of biomedical articles  

PubMed Central

Background Receiving extraneous articles in response to a query submitted to MEDLINE/PubMed is common. When submitting a multi-word query (which is the majority of queries submitted), the presence of all query words within each article may be a necessary condition for retrieving relevant articles, but not sufficient. Ideally a relationship between the query words in the article is also required. We propose that if two words occur within an article, the probability that a relation between them is explained is higher when the words occur within adjacent sentences versus remote sentences. Therefore, sentence-level concurrence can be used as a surrogate for existence of the relationship between the words. In order to avoid the irrelevant articles, one solution would be to increase the search specificity. Another solution is to estimate a relevance score to sort the retrieved articles. However among the >30 retrieval services available for MEDLINE, only a few estimate a relevance score, and none detects and incorporates the relation between the query words as part of the relevance score. Results We have developed "Relemed", a search engine for MEDLINE. Relemed increases specificity and precision of retrieval by searching for query words within sentences rather than the whole article. It uses sentence-level concurrence as a statistical surrogate for the existence of relationship between the words. It also estimates a relevance score and sorts the results on this basis, thus shifting irrelevant articles lower down the list. In two case studies, we demonstrate that the most relevant articles appear at the top of the Relemed results, while this is not necessarily the case with a PubMed search. We have also shown that a Relemed search includes not only all the articles retrieved by PubMed, but potentially additional relevant articles, due to the extended 'automatic term mapping' and text-word searching features implemented in Relemed. Conclusion By using sentence-level matching, Relemed can deliver higher specificity, thus eliminating more false-positive articles. By introducing an appropriate relevance metric, the most relevant articles on which the user wishes to focus are listed first. Relemed also shrinks the displayed text, and hence the time spent scanning the articles.

Siadaty, Mir S; Shu, Jianfen; Knaus, William A

2007-01-01

113

A Cochrane Systematic Review finds no significant difference in outcome or risk of postoperative complications between day care and in-patient cataract surgery.  

PubMed

This review was conducted to determine reliable evidence regarding the safety, feasibility, effectiveness, and cost-effectiveness of cataract extraction performed as a day care versus in-patient procedure. The search to identify randomized controlled trials comparing day care and in-patient surgery for age-related cataract included the Cochrane Eyes and Vision Group Trials Register, the Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE and LILACS Latin American and Caribbean Literature on Health Sciences. Assessment of methodological quality was based on criteria defined by the Cochrane Collaboration. The primary outcome was the achievement of a satisfactory visual acuity 6 weeks after operation. Two trials, involving a total of 1284 people, are included. One trial reported statistically significant differences in early postoperative complication rates in the day care group, which had no clinical relevance to visual outcomes 4 months postoperatively. Mean change in visual acuity Snellen lines of the operated eye 4 months postoperatively was 4.1 standard deviation SD 2.3 for the day care group and 4.1 SD 2.2 for the in-patient group. Costs were 20% more for the in-patient group attributable to higher costs for overnight stay. PMID:16951761

Fedorowicz, Zbigniew; Lawrence, David J; Gutierrez, Peter

2006-09-01

114

Building a miniMEDLINE database: which journals to choose?  

PubMed Central

Scott Memorial Library (SML) at Thomas Jefferson University has installed the Library Information System (LIS) developed by Georgetown University Medical Center Library. One component of the system is miniMEDLINE, a system for searching an inhouse database derived from NLM MEDLINE tapes. This paper describes the process involved in determining which journals should be included in SML's miniMEDLINE file; the number of titles and years covered; the balance between research and clinical titles; the representation of allied health fields; and the level of faculty involvement.

Laynor, B; Calabretta, N; Ross, R

1988-01-01

115

Improving accuracy for identifying related PubMed queries by an integrated approach  

PubMed Central

PubMed is the most widely used tool for searching biomedical literature online. As with many other online search tools, a user often types a series of multiple related queries before retrieving satisfactory results to fulfill a single information need. Meanwhile, it is also a common phenomenon to see a user type queries on unrelated topics in a single session. In order to study PubMed users’ search strategies, it is necessary to be able to automatically separate unrelated queries and group together related queries. Here, we report a novel approach combining both lexical and contextual analyses for segmenting PubMed query sessions and identifying related queries and compare its performance with the previous approach based solely on concept mapping. We experimented with our integrated approach on sample data consisting of 1,539 pairs of consecutive user queries in 351 user sessions. The prediction results of 1,396 pairs agreed with the gold-standard annotations, achieving an overall accuracy of 90.7%. This demonstrates that our approach is significantly better than the previously published method. By applying this approach to a one day query log of PubMed, we found that a significant proportion of information needs involved more than one PubMed query, and that most of the consecutive queries for the same information need are lexically related. Finally, the proposed PubMed distance is shown to be an accurate and meaningful measure for determining the contextual similarity between biological terms. The integrated approach can play a critical role in handling real-world PubMed query log data as is demonstrated in our experiments.

Lu, Zhiyong; Wilbur, W. John

2009-01-01

116

Twenty years of Cochrane reviews in menstrual disorders and subfertility.  

PubMed

The past three decades have seen considerable change in the understanding of clinical research methods. There has been an acceptance that RCTs are the best way of establishing treatment effectiveness and a recognition that, while single studies are useful, pooling knowledge from a complete body of work is likely to provide the best evidence. Advances in methodology have been mirrored by the many advances in the field of reproductive medicine, such as assisted reproduction, assessment of male fertility, ovulation induction and laparoscopic surgery. Together, they have led to welcome improvements in the outcomes of fertility treatments. In particular, systematic reviews have become important tools enabling clinicians and patients to make health-care decisions based on evidence from all the available high-quality studies. The move towards identifying and aggregating the highest quality evidence has been led by the Cochrane Collaboration, which this year celebrates 20 years of preparing and publishing systematic reviews. This paper outlines the achievements, progress and challenges of this enterprise to date, with a particular focus on systematic reviews of reproductive medicine. PMID:23990642

Farquhar, Cindy; Moore, Vivienne; Bhattacharya, Siladitya; Blake, Debbie; Vail, Andy; Thomas, Jane; Cheong, Ying; Showell, Marian; Nagels, Helen; Marjoribanks, Jane

2013-08-29

117

Power Naps for Preschoolers: MedlinePlus Health News Video  

MedlinePLUS

... lower right-hand corner of the player. Power Naps for Preschoolers HealthDay September 24, 2013 Related MedlinePlus Pages Child Development School Health Transcript A nap does a preschooler's body, and mind good. That's ...

118

ADHD and Medication: MedlinePlus Health News Video  

MedlinePLUS

... the lower right-hand corner of the player. ADHD and Medication HealthDay September 30, 2013 Related MedlinePlus Pages Attention Deficit Hyperactivity Disorder Child Mental Health Transcript Psychotropic drugs alter chemical ...

119

Creating the First MedlinePlus “Go Local” Service  

Microsoft Academic Search

NC Health Info is an online collection of North Carolina-based health services Web sites that seamlessly links local health resources to topical health information on MedlinePlus, the National Library of Medicine's consumer health information Web site. NC Health Info was the first project to connect local resources with MedlinePlus in the “Go Local” initiative. As such, NC Health Info serves

Christie Silbajoris; Diana McDuffee; Cynthia Olney

2007-01-01

120

Semantically linking and browsing PubMed abstracts with gene ontology  

PubMed Central

Background The technological advances in the past decade have lead to massive progress in the field of biotechnology. The documentation of the progress made exists in the form of research articles. The PubMed is the current most used repository for bio-literature. PubMed consists of about 17 million abstracts as of 2007 that require methods to efficiently retrieve and browse large volume of relevant information. The State-of-the-art technologies such as GOPubmed use simple keyword-based techniques for retrieving abstracts from the PubMed and linking them to the Gene Ontology (GO). This paper changes the paradigm by introducing semantics enabled technique to link the PubMed to the Gene Ontology, called, SEGOPubmed for ontology-based browsing. Latent Semantic Analysis (LSA) framework is used to semantically interface PubMed abstracts to the Gene Ontology. Results The Empirical analysis is performed to compare the performance of the SEGOPubmed with the GOPubmed. The analysis is initially performed using a few well-referenced query words. Further, statistical analysis is performed using GO curated dataset as ground truth. The analysis suggests that the SEGOPubmed performs better than the classic GOPubmed as it incorporates semantics. Conclusions The LSA technique is applied on the PubMed abstracts obtained based on the user query and the semantic similarity between the query and the abstracts. The analyses using well-referenced keywords show that the proposed semantic-sensitive technique outperformed the string comparison based techniques in associating the relevant abstracts to the GO terms. The SEGOPubmed also extracted the abstracts in which the keywords do not appear in isolation (i.e. they appear in combination with other terms) that could not be retrieved by simple term matching techniques.

Vanteru, Bhanu C; Shaik, Jahangheer S; Yeasin, Mohammed

2008-01-01

121

An automatic method to generate domain-specific investigator networks using PubMed abstracts  

PubMed Central

Background Collaboration among investigators has become critical to scientific research. This includes ad hoc collaboration established through personal contacts as well as formal consortia established by funding agencies. Continued growth in online resources for scientific research and communication has promoted the development of highly networked research communities. Extending these networks globally requires identifying additional investigators in a given domain, profiling their research interests, and collecting current contact information. We present a novel strategy for building investigator networks dynamically and producing detailed investigator profiles using data available in PubMed abstracts. Results We developed a novel strategy to obtain detailed investigator information by automatically parsing the affiliation string in PubMed records. We illustrated the results by using a published literature database in human genome epidemiology (HuGE Pub Lit) as a test case. Our parsing strategy extracted country information from 92.1% of the affiliation strings in a random sample of PubMed records and in 97.0% of HuGE records, with accuracies of 94.0% and 91.0%, respectively. Institution information was parsed from 91.3% of the general PubMed records (accuracy 86.8%) and from 94.2% of HuGE PubMed records (accuracy 87.0). We demonstrated the application of our approach to dynamic creation of investigator networks by creating a prototype information system containing a large database of PubMed abstracts relevant to human genome epidemiology (HuGE Pub Lit), indexed using PubMed medical subject headings converted to Unified Medical Language System concepts. Our method was able to identify 70–90% of the investigators/collaborators in three different human genetics fields; it also successfully identified 9 of 10 genetics investigators within the PREBIC network, an existing preterm birth research network. Conclusion We successfully created a web-based prototype capable of creating domain-specific investigator networks based on an application that accurately generates detailed investigator profiles from PubMed abstracts combined with robust standard vocabularies. This approach could be used for other biomedical fields to efficiently establish domain-specific investigator networks.

Yu, Wei; Yesupriya, Ajay; Wulf, Anja; Qu, Junfeng; Gwinn, Marta; Khoury, Muin J

2007-01-01

122

Archibald Leman Cochrane 1909–1988: a meaningful life in science and history  

Microsoft Academic Search

Andre Breton, and the surrealist movement, called a livreobjet, a book that was a piece of art in its form and not only in its content (Picture 1). Xavier Bosch has produced a wonderful livre-objet on Archie Cochrane, entitled: “Archibald Cochrane: back to the front” (Picture 2) (Bosch 2003). It has pictures, testimonies, citations of historians and novelists. The book

Alfredo Morabia

2004-01-01

123

SLIM: an alternative Web interface for MEDLINE/PubMed searches - a preliminary study  

PubMed Central

Background With the rapid growth of medical information and the pervasiveness of the Internet, online search and retrieval systems have become indispensable tools in medicine. The progress of Web technologies can provide expert searching capabilities to non-expert information seekers. The objective of the project is to create an alternative search interface for MEDLINE/PubMed searches using JavaScript slider bars. SLIM, or Slider Interface for MEDLINE/PubMed searches, was developed with PHP and JavaScript. Interactive slider bars in the search form controlled search parameters such as limits, filters and MeSH terminologies. Connections to PubMed were done using the Entrez Programming Utilities (E-Utilities). Custom scripts were created to mimic the automatic term mapping process of Entrez. Page generation times for both local and remote connections were recorded. Results Alpha testing by developers showed SLIM to be functionally stable. Page generation times to simulate loading times were recorded the first week of alpha and beta testing. Average page generation times for the index page, previews and searches were 2.94 milliseconds, 0.63 seconds and 3.84 seconds, respectively. Eighteen physicians from the US, Australia and the Philippines participated in the beta testing and provided feedback through an online survey. Most users found the search interface user-friendly and easy to use. Information on MeSH terms and the ability to instantly hide and display abstracts were identified as distinctive features. Conclusion SLIM can be an interactive time-saving tool for online medical literature research that improves user control and capability to instantly refine and refocus search strategies. With continued development and by integrating search limits, methodology filters, MeSH terms and levels of evidence, SLIM may be useful in the practice of evidence-based medicine.

Muin, Michael; Fontelo, Paul; Liu, Fang; Ackerman, Michael

2005-01-01

124

Development and classification of an operational definition of complementary and alternative medicine for the Cochrane Collaboration  

PubMed Central

Over the past decade the Cochrane Collaboration has been an increasingly important source of information on complementary and alternative medicine (CAM) therapies. From 2007 to 2008 the Cochrane CAM Field developed a topics list that allowed us to categorize all 396 Cochrane reviews related to CAM (as of The Cochrane Library, Issue 4, 2009). This topics list is an advance in making Cochrane reviews on CAM topics accessible to the public. In this paper, we discuss challenges in developing the topics list, including developing an operational definition of CAM, deciding which reviews should be included within the CAM Field’s scope, developing the structured list of CAM Field-specific topics, and determining where in the topics list the reviews should be placed. Although aspects of our operational definition of CAM are open to revision, a standardized definition provides us with an objective, reproducible and systematic method for defining and classifying CAM therapies.

Wieland, L. Susan; Manheimer, Eric; Berman, Brian M.

2011-01-01

125

Risk Factors for Bladder Cancer: Challenges of Conducting a Literature Search Using PubMed  

PubMed Central

The objective of this study was to assess the risk factors for bladder cancer using PubMed articles from January 2000 to December 2009. The study also aimed to describe the challenges encountered in the methodology of a literature search for bladder cancer risk factors using PubMed. Twenty-six categories of risk factors for bladder cancer were identified using the National Cancer Institute Web site and the Medical Subject Headings (MeSH) Web site. A total of 1,338 PubMed searches were run using the term “urinary bladder cancer” and a risk factor term (e.g., “cigarette smoking”) and were screened to identify 260 articles for final analysis. The search strategy had an overall precision of 3.42 percent, relative recall of 12.64 percent, and an F -measure of 5.39 percent. Although search terms derived from MeSH had the highest overall precision and recall, the differences did not reach significance, which indicates that for generalized, free-text searches of the PubMed database, the searchers' own terms are generally as effective as MeSH terms.

Joshi, Ashish; Preslan, Elicia

2011-01-01

126

Multi-lingual Search Engine to Access PubMed Monolingual Subsets: A Feasibility Study.  

PubMed

PubMed contains many articles in languages other than English but it is difficult to find them using the English version of the Medical Subject Headings (MeSH) Thesaurus. The aim of this work is to propose a tool allowing access to a PubMed subset in one language, and to evaluate its performance. Translations of MeSH were enriched and gathered in the information system. PubMed subsets in main European languages were also added in our database, using a dedicated parser. The CISMeF generic semantic search engine was evaluated on the response time for simple queries. MeSH descriptors are currently available in 11 languages in the information system. All the 654,000 PubMed citations in French were integrated into CISMeF database. None of the response times exceed the threshold defined for usability (2 seconds). It is now possible to freely access biomedical literature in French using a tool in French; health professionals and lay people with a low English language may find it useful. It will be expended to several European languages: German, Spanish, Norwegian and Portuguese. PMID:23920740

Darmoni, Stéfan J; Soualmia, Lina F; Griffon, Nicolas; Grosjean, Julien; Kerdelhué, Gaétan; Kergourlay, Ivan; Dahamna, Badisse

2013-01-01

127

Matching references with MEDLINE via TCP/IP.  

PubMed

Bibliographic references are an important part of databases and information resources used by clinicians and biomedical researchers. In addition to the obvious clerical advantages of standard references, bibliographic references can also be used as links to related items in different data sets. This paper describes an effort that involved matching references from a variety of disparate databases to canonical MEDLINE references. The references matched were those involved in a database unification project which is part of the Mouse Genome Informatics effort at The Jackson Laboratory. Software was developed to take advantage of a commercially available retrieval engine which accesses MEDLINE on CD-ROM disks. The software permits client programs on UNIX/C, and potentially other environments, to access unabridged MEDLINE via networks supporting the TCP/IP protocols. The matching process described can be used as a model for similar efforts with different research or clinical data sets, as well as different hardware or software environments. PMID:8130546

Guidi, J N

1993-01-01

128

Matching references with MEDLINE via TCP/IP.  

PubMed Central

Bibliographic references are an important part of databases and information resources used by clinicians and biomedical researchers. In addition to the obvious clerical advantages of standard references, bibliographic references can also be used as links to related items in different data sets. This paper describes an effort that involved matching references from a variety of disparate databases to canonical MEDLINE references. The references matched were those involved in a database unification project which is part of the Mouse Genome Informatics effort at The Jackson Laboratory. Software was developed to take advantage of a commercially available retrieval engine which accesses MEDLINE on CD-ROM disks. The software permits client programs on UNIX/C, and potentially other environments, to access unabridged MEDLINE via networks supporting the TCP/IP protocols. The matching process described can be used as a model for similar efforts with different research or clinical data sets, as well as different hardware or software environments.

Guidi, J. N.

1993-01-01

129

Literature search on risk factors for sarcoma: PubMed and Google Scholar may be complementary sources  

Microsoft Academic Search

BACKGROUND: Within the context of a European network dedicated to the study of sarcoma the relevant literature on sarcoma risk factors was collected by searching PubMed and Google Scholar, the two information storage and retrieval databases which can be accessed without charge. The present study aims to appraise the relative proficiency of PubMed and Google Scholar. FINDINGS: Unlike PubMed, Google

Giuseppe Mastrangelo; Emanuela Fadda; Carlo R Rossi; Emanuele Zamprogno; Alessandra Buja; Luca Cegolon

2010-01-01

130

Death, dying and informatics: misrepresenting religion on MedLine  

Microsoft Academic Search

BACKGROUND: The globalization of medical science carries for doctors worldwide a correlative duty to deepen their understanding of patients' cultural contexts and religious backgrounds, in order to satisfy each as a unique individual. To become better informed, practitioners may turn to MedLine, but it is unclear whether the information found there is an accurate representation of culture and religion. To

Pablo Rodríguez del Pozo; Joseph J Fins

2005-01-01

131

Portraying Islam and Muslims in MEDLINE: A content analysis  

Microsoft Academic Search

The growing number and diversity of Muslims in the United States and Western Europe challenge clinicians and researchers to understand this population's perspectives and experiences regarding health and biomedicine. For information about Muslim patient populations, clinicians and researchers routinely consult medical literature. To examine how this literature portrays Muslims, we conducted an ethnographic content analysis of 2342 OVID MEDLINE-indexed abstracts

Lance Daniel Laird; Justine de Marrais; Linda L. Barnes

2007-01-01

132

Preventing Concussions: MedlinePlus Health News Video  

MedlinePLUS

... HealthDay October 28, 2013 Related MedlinePlus Pages Concussion Sports Safety Teen Health Transcript Your child insists on playing high school football, so you go out and buy the best safety gear on the market. The ads claim there's science behind the products, so you buy. Now, a ...

133

NIH Quickfinder | NIH MedlinePlus the Magazine  

MedlinePLUS

... 1770 NIH MedlinePlus Advisory Group Marin P. Allen, Ph.D., Office of Communications and Public Liaison, NIH Joyce ... of Allergy and Infectious Diseases Richard E. Manrow, Ph.D., National Cancer Institute John McGrath, Ph.D., National ...

134

PubMedAlertMe - Standalone Windows-based PubMed SDI Software Application  

PubMed Central

PubMedAlertMe is a Windows-based software system for automatically receiving e-mail alert messages about recent publications listed on PubMed. The e-mail messages contain links to newly available abstracts listed on PubMed describing publications that were selectively returned from a specified list of queries. Links are also provided to directly export citations to EndNote, and links are provided to directly forward articles to colleagues. The program is standalone. Thus, it does not require a remote mail server or user registration. PubMedAlertMe is free software, and can be downloaded from: http://amp.pharm.mssm.edu/PubMedAlertMe/PubMedAlertMe_setup.zip

Ma'ayan, Avi

2008-01-01

135

Comparison of PubMed, Scopus, Web of Science, and Google Scholar: strengths and weaknesses.  

PubMed

The evolution of the electronic age has led to the development of numerous medical databases on the World Wide Web, offering search facilities on a particular subject and the ability to perform citation analysis. We compared the content coverage and practical utility of PubMed, Scopus, Web of Science, and Google Scholar. The official Web pages of the databases were used to extract information on the range of journals covered, search facilities and restrictions, and update frequency. We used the example of a keyword search to evaluate the usefulness of these databases in biomedical information retrieval and a specific published article to evaluate their utility in performing citation analysis. All databases were practical in use and offered numerous search facilities. PubMed and Google Scholar are accessed for free. The keyword search with PubMed offers optimal update frequency and includes online early articles; other databases can rate articles by number of citations, as an index of importance. For citation analysis, Scopus offers about 20% more coverage than Web of Science, whereas Google Scholar offers results of inconsistent accuracy. PubMed remains an optimal tool in biomedical electronic research. Scopus covers a wider journal range, of help both in keyword searching and citation analysis, but it is currently limited to recent articles (published after 1995) compared with Web of Science. Google Scholar, as for the Web in general, can help in the retrieval of even the most obscure information but its use is marred by inadequate, less often updated, citation information. PMID:17884971

Falagas, Matthew E; Pitsouni, Eleni I; Malietzis, George A; Pappas, Georgios

2007-09-20

136

Searching PubMed on an iPhone or iPod Touch  

Microsoft Academic Search

An increasing number of students and faculty come to campus with an iPhone or iPod touch. Aside from recreational use, these devices can be used to search for medical literature, but picking the right applications for searching can be difficult. A comparison test was created to find the best application for searching PubMed from an iPhone or iPod touch. The

Michelle Price

2010-01-01

137

78 FR 62678 - Morris W. Cochran, M.D.; Decision and Order  

Federal Register 2010, 2011, 2012, 2013

...13-17] Morris W. Cochran, M.D.; Decision and Order On July 9, 2013, Administrative...ALJ) issued the attached Recommended Decision. Therein, the ALJ found that there...exceptions to the ALJ's Recommended Decision. [[Page 62679

2013-10-22

138

Research synthesis and dissemination as a bridge to knowledge management: the Cochrane Collaboration  

Microsoft Academic Search

In the current information age, research synthesis is a particularly useful tool for keeping track of scientific research and making sense of the large volumes of frequently conflicting data derived from primary studies. The Cochrane Collaboration is a global initiative \\

Jimmy Volmink; Nandi Siegfried; Katharine Robertson; A. Metin Gülmezoglu

2004-01-01

139

Literature Mapping with PubAtlas -- extending PubMed with a 'BLASTing interface' *  

PubMed Central

PubAtlas (www.pubatlas.org) is a web service and standalone program providing literature maps for the biomedical research literature. It accepts user-defined sets of terms (PubMed queries) as input, and permits ‘BLASTing’ of one set against another: for all terms x and y in these sets, deriving the results of the pairwise intersections x AND y. This all vs. all capability extends PubMed with a literature analysis interface. Correspondingly, the basic form of literature map that PubAtlas provides for exploring associations among sets of terms is an interactive tabular display, in heatmap/microarray format. PubAtlas supports development of specialized lexica -- hierarchies of controlled terminology that can represent sets of related concepts or a ‘user-defined query language’. PubAtlas also provides historical perspectives on the literature, with temporal query features that highlight historical patterns. Generally, it is a framework for extending the PubMed interface, and an extensible platform for producing interactive literature maps.

Parker, D.S.; Chu, W.W.; Sabb, F.W.; Toga, A.W.; Bilder, R.M.

2009-01-01

140

Challenges and strategies of increasing the production and use of Cochrane reviews: the Argentinean experience.  

PubMed

The Cochrane Collaboration (CC), established in 1993, is an internationally renowned initiative dedicated to improving health care for the world's population. In the late 1990 s, the Iberoamerican Cochrane Centre (IbCC) was created to promote the CC in Latin America. Because the production and use of Cochrane reviews were still low in 2002, Argentina implemented specific strategies and a model to expand the IbCC. The objective of this article was to describe strategies to increase the production and use of Cochrane reviews in Argentina. Methods used included surveys delivered to primary health care workers to provide data about their knowledge and use of the CC, and about the production of titles, protocols, and systematic reviews published in the Cochrane Library. Our survey showed that only 51% of a selected population of primary healthcare workers knew about the CC and only 23% knew about the Argentine Cochrane centre. In the previous year, 60% had never used the CC. To overcome these challenges, we used seven types of complementary strategies: (1) networking, (2) dissemination, (3) training, (4) support to Cochrane members, (5) strategic alliances, (6) research, and (7) fund-raising. An improvement in the production and use of Cochrane reviews was seen in Argentina, and the set of aforementioned strategies could be partly responsible for this increase. Multi-level networking, training and an appropriate centre's mother institution could be the most important interventions. More research is needed to explore this hypothesis. Lessons learned on this first evaluation will help us to continue with the development of the CC in Argentina. PMID:18237346

Ciapponi, Agustín

2008-01-01

141

Extracts from the Cochrane Library: functional endoscopic balloon dilation of sinus ostia for chronic rhinosinusitis.  

PubMed

The "Cochrane Corner" is a quarterly section in the Journal that highlights systematic reviews relevant to otolaryngology-head and neck surgery, with invited commentary to aid clinical decision making. This installment features a Cochrane Review, titled "Functional Endoscopic Balloon Dilation of Sinus Ostia for Chronic Rhinosinusitis," that finds no convincing evidence supporting balloon dilation compared to conventional surgical modalities for managing refractory disease. PMID:21835929

Burton, Martin J; Bhattacharyya, Neil; Rosenfeld, Richard M

2011-08-11

142

Reporting of conflicts of interest from drug trials in Cochrane reviews: cross sectional study  

PubMed Central

Objectives To investigate the degree to which Cochrane reviews of drug interventions published in 2010 reported conflicts of interest from included trials and, among reviews that reported this information, where it was located in the review documents. Design Cross sectional study. Data sources Cochrane Database of Systematic Reviews. Selection criteria Systematic reviews of drug interventions published in 2010 in the Cochrane Database of Systematic Reviews, with review content classified as up to date in 2008 or later and with results from one or more randomised controlled trials. Results Of 151 included Cochrane reviews, 46 (30%, 95% confidence interval 24% to 38%) reported information on the funding sources of included trials, including 30 (20%, 14% to 27%) that reported information on trial funding for all included trials and 16 (11%, 7% to 17%) that reported for some, but not all, trials. Only 16 of the 151 Cochrane reviews (11%, 7% to 17%) provided any information on trial author-industry financial ties or trial author-industry employment. Information on trial funding and trial author-industry ties was reported in one to seven locations within each review, with no consistent reporting location observed. Conclusions Most Cochrane reviews of drug trials published in 2010 did not provide information on trial funding sources or trial author-industry financial ties or employment. When this information was reported, location of reporting was inconsistent across reviews.

2012-01-01

143

File maintenance of MeSH headings in MEDLINE.  

PubMed

This article addresses file maintenance of subject headings in the National Library of Medicine's MEDLINE, a bibliographic retrieval file which is indexed using Medical Subject Headings (MeSH), NLM's subject authority. The emphasis is class maintenance in which sets of records in MEDLINE are changed by maintenance actions which reflect yearly changes in MeSH. Specific types of maintenance action are described with examples to highlight problem areas. Class maintenance failures, checking class maintenance, and informing end-users of MeSH changes resulting in class maintenance are discussed. Technical constraints and feasibility are not analyzed in detail; rather, the approach is geared toward requirements and impact of maintenance from the standpoint of vocabulary specialists and end-users. The article concludes with a brief statement on defining file maintenance policy. PMID:10299353

Humphrey, S M

1984-01-01

144

Medline for Medical Students? Searching for the Right Answer  

Microsoft Academic Search

Objective: Does MEDLINE use, when added to more traditional sources of information, improve the accuracy of medical students' clinical decisions\\u000a when compared to those obtained using traditional sources only? Design: Randomized control trial. Setting: McMaster University Faculty of Medicine, Undergraduate Program. Participants: The entire class of 101 medical students, class of 1998. Overall response rate on 9items was 56% (510\\/909),

Harold I. Reiter; Alan J. Neville; Geoffrey Norman

2000-01-01

145

On the query reformulation technique for effective MEDLINE document retrieval.  

PubMed

Improving the retrieval accuracy of MEDLINE documents is still a challenging issue due to low retrieval precision. Focusing on a query expansion technique based on pseudo-relevance feedback (PRF), this paper addresses the problem by systematically examining the effects of expansion term selection and adjustment of the term weights of the expanded query using a set of MEDLINE test documents called OHSUMED. Implementing a baseline information retrieval system based on the Okapi BM25 retrieval model, we compared six well-known term ranking algorithms for useful expansion term selection and then compared traditional term reweighting algorithms with our new variant of the standard Rocchio's feedback formula, which adopts a group-based weighting scheme. Our experimental results on the OHSUMED test collection showed a maximum improvement of 20.2% and 20.4% for mean average precision and recall measures over unexpanded queries when terms were expanded using a co-occurrence analysis-based term ranking algorithm in conjunction with our term reweighting algorithm (p-value<0.05). Our study shows the behaviors of different query reformulation techniques that can be utilized for more effective MEDLINE document retrieval. PMID:20394839

Yoo, Sooyoung; Choi, Jinwook

2010-04-13

146

Thomas McKeown and Archibald Cochrane: a journey through the diffusion of their ideas.  

PubMed Central

In the 1970s Thomas McKeown and Archibald L Cochrane were two of the most influential voices in criticizing the dominance of medical thinking. A bibliometric study of the citations to McKeown's The Role of Medicine: Dream, Mirage or Nemesis and Cochrane's Effectiveness and Efficiency: Random Reflections on Health Services was performed from the publication of each book until 1988 to study how their ideas have been disseminated. During the study period 430 papers in the Science Citation Index or the Social Sciences Citation Index cited Cochrane's book, 133 cited McKeown's, and 166 cited both. The citations came mainly from original papers published in journals of internal medicine or public health and epidemiology (35%) and written by authors from the United States or the United Kingdom. Cochrane's book was cited most frequently in medical journals, suggesting a higher degree of penetration of his ideas among medical scientists. Although the dominance of original papers among the citations suggests that these books have been important in stimulating new knowledge, the main problems that McKeown and Cochrane identified--namely, the relatively small impact of clinical medicine on health outcomes and the poor use of scientific methods in clinical practice--are still with us.

Alvarez-Dardet, C; Ruiz, M T

1993-01-01

147

Geography of Africa biomedical publications: An analysis of 1996-2005 PubMed papers  

PubMed Central

Background Scientific publications play an important role in scientific process providing a key linkage between knowledge production and use. Scientific publishing activity worldwide over the past decades shows that most countries in Africa have low levels of publication. We sought to examine trends and contribution of different Africa subregions and individual countries as represented by the articles indexed by PubMed between 1996 and 2005. Results Research production in Africa is highly skewed; South Africa, Egypt, and Nigeria make up a striking 60% of the total number of articles indexed by PubMed between 1996 and 2005. When adjusted for population size smaller countries, such as The Gambia, Gabon and Botswana, were more productive than Nigeria and Kenya. The Gambia and Eritrea had better records when total production was adjusted for gross domestic product. The contribution of Africa to global research production was persistently low through the period studied. Conclusion In this study, we found that most populous and rich countries (such as South Africa, Egypt, and Nigeria) have correspondingly higher research production; but smaller countries can be productive. We noted continuous increases and reassuring trends in the production of research articles from all African subregions during the period 1996 – 2005. However, contribution of Africa to global research production was limited.

Uthman, Olalekan A; Uthman, Mubashir B

2007-01-01

148

LitInspector: literature and signal transduction pathway mining in PubMed abstracts.  

PubMed

LitInspector is a literature search tool providing gene and signal transduction pathway mining within NCBI's PubMed database. The automatic gene recognition and color coding increases the readability of abstracts and significantly speeds up literature research. A main challenge in gene recognition is the resolution of homonyms and rejection of identical abbreviations used in a 'non-gene' context. LitInspector uses automatically generated and manually refined filtering lists for this purpose. The quality of the LitInspector results was assessed with a published dataset of 181 PubMed sentences. LitInspector achieved a precision of 96.8%, a recall of 86.6% and an F-measure of 91.4%. To further demonstrate the homonym resolution qualities, LitInspector was compared to three other literature search tools using some challenging examples. The homonym MIZ-1 (gene IDs 7709 and 9063) was correctly resolved in 87% of the abstracts by LitInspector, whereas the other tools achieved recognition rates between 35% and 67%. The LitInspector signal transduction pathway mining is based on a manually curated database of pathway names (e.g. wingless type), pathway components (e.g. WNT1, FZD1), and general pathway keywords (e.g. signaling cascade). The performance was checked for 10 randomly selected genes. Eighty-two per cent of the 38 predicted pathway associations were correct. LitInspector is freely available at http://www.litinspector.org/. PMID:19417065

Frisch, Matthias; Klocke, Bernward; Haltmeier, Manuela; Frech, Kornelie

2009-05-05

149

How can a proposed Cochrane diet and nutrition field work effectively?  

PubMed

The Cochrane Database currently provides relatively little evidence-based guidance about nutrition relevant to general practitioners. This situation could be improved by the establishment of a new Cochrane Field to identify relevant studies, prioritize topics to include nutrition, work with Cochrane methodologists on the inclusion of observational studies, and disseminate results of Cochrane reviews to general practitioners and their patients. A Diet and Nutrition Field could be established as a separate entity or as a Subgroup of the existing Primary Health Care (PHC) Field. The Field would be appropriate if the intent is to immediately cover nutritional interventions of all sorts, in all settings. However, if the focus is nutritional evidence for use by primary care clinicians, organization as a subField would provide a simpler registration process, allow Cochrane activities to begin sooner, and would allow members to focus on primary-care-relevant nutritional issues, conserving their resources and energy. A mechanism exists for conversion to a freestanding Field if the scope later expands. Of the core Field functions, identification and assembly of relevant trials into a specialized register would be among the most important. Special registers are generated by focused literature searches augmented by hand-searching of key journals. Given the importance of studies with observational designs, a nutrition field register will require some additional work on search strategies and inclusion criteria. Other key functions would include ensuring effective communication both with members of other Cochrane entities and with the scientific and clinical community with interests in diet and nutrition. PMID:16052186

Becker, L A; van Binsbergen, J J

2005-08-01

150

Seasonal Allergy Research at NIH | NIH MedlinePlus the Magazine  

MedlinePLUS

... this page please turn Javascript on. Feature: Managing Allergies Seasonal Allergy Research at NIH Past Issues / Spring 2013 Table of Contents To Find Out More MedlinePlus: Allergy www.nlm.nih.gov/medlineplus/allergy.html MedlinePlus: ...

151

MedlinePlus 2011 User Survey Results: How frequently do you visit this site?  

MedlinePLUS

... features on this page, please enable JavaScript. 2011 User Survey Results: Slide Index | Next How frequently do you visit this site? Responses: First time MedlinePlus users 42% MedlinePlus en español users 35% More than ...

152

MedlinePlus Connect: Linking Patient Portals and Electronic Health Records to Health Information  

MedlinePLUS

... health IT providers to link patient portals and electronic health record (EHR) systems to MedlinePlus, an authoritative ... information. See examples of health care organizations and electronic health records systems using MedlinePlus Connect . Quick Facts ...

153

Developing Topic-specific Search Filters for PubMed with Click-through Data.  

PubMed

Objectives: Search filters have been developed and demonstrated for better information access to the immense and ever-growing body of publications in the biomedical domain. However, to date the number of filters remains quite limited because the current filter development methods require significant human efforts in manual document review and filter term selection. In this regard, we aim to investigate automatic methods for generating search filters. Methods: We present an automated method to develop topic-specific filters on the basis of users' search logs in PubMed. Specifically, for a given topic, we first detect its relevant user queries and then include their corresponding clicked articles to serve as the topic-relevant document set accordingly. Next, we statistically identify informative terms that best represent the topic-relevant document set using a background set composed of topic irrelevant articles. Lastly, the selected representative terms are combined with Boolean operators and evaluated on benchmark datasets to derive the final filter with the best performance. Results: We applied our method to develop filters for four clinical topics: nephrology, diabetes, pregnancy, and depression. For the nephrology filter, our method obtained performance comparable to the state of the art (sensitivity of 91.3%, specificity of 98.7%, precision of 94.6%, and accuracy of 97.2%). Similarly, high-performing results (over 90% in all measures) were obtained for the other three search filters. Conclusion: Based on PubMed click-through data, we successfully developed a high-performance method for generating topic-specific search filters that is significantly more efficient than existing manual methods. All data sets (topic-relevant and irrelevant document sets) used in this study and a demonstration system are publicly available at http://www.ncbi.nlm.nih.gov/CBBresearch/Lu/downloads/CQ_filter/ PMID:23666447

Li, J; Lu, Z

2013-05-13

154

Metformin versus oral contraceptive pill in polycystic ovary syndrome: a Cochrane review  

Microsoft Academic Search

BACKGROUND: The object of this review was to compare metformin versus oral contraceptive pill (OCP) treatment in polycystic ovary syndrome. METHODS: A systematic review and meta-analysis employing the principles of the Cochrane Menstrual Disorders and Subfertility Group was undertaken. RESULTS: Four randomized controlled trials (RCTs) (104 subjects) were included. Limited data demonstrated no evidence of a difference in effect between

Michael F. Costello; Bhushan Shrestha; John Eden; Neil P. Johnson; Peter Sjoblom

2007-01-01

155

Assessing Diagnostic Expertise of Counselors Using the Cochran-Weiss-Shanteau (CWS) Index  

ERIC Educational Resources Information Center

|Counseling studies have shown that increasing experience is not always associated with better judgments. However, in such studies performance is assessed against external criteria, which may lack validity. The authors applied the Cochran-Weiss-Shanteau (CWS) index, which assesses the ability to consistently discriminate. Results showed that…

Witteman, Cilia L. M.; Weiss, David J.; Metzmacher, Martin

2012-01-01

156

Ideology and Reform in Teacher Education in England: Some Reflections on Cochran-Smith and Fries.  

ERIC Educational Resources Information Center

|Presents an international perspective on Cochran-Smith and Fries' recent analysis of the ways that two competing ideologies (deregulation and professionalization) are being employed in the United States to support teacher education reform, noting important differences between the United States and England in how these ideologies have been…

Furlong, John

2002-01-01

157

Is management of acute traumatic brain injury effective? A literature review of published Cochrane Systematic Reviews.  

PubMed

Objective: To evaluate all the possible therapeutic measures concerning the acute management of traumatic brain injury (TBI) mentioned in Cochrane Systematic Reviews published in the Cochrane Database of Systematic Reviews (CDSR). Methods: An exhausted literature search for all published Cochrane Systematic Reviews discussing therapeutic rather than prevention or rehabilitative interventions of TBI was conducted. We retrieved such databases as CDSR and Cochrane Injury Group, excluded the duplications, and eventually obtained 20 results, which stand for critical appraisal for as many as 20 different measures for TBI patients. The important data of each systematic review, including total population, intervention, outcome, etc, were collected and presented in a designed table. Besides, we also tried to find out the possible weakness of these clinical trials included in each review. Results: Analysis of these reviews yielded meanfuling observations: (1) The effectiveness of most ordinary treatments in TBI is inconclusive except that corticosteroids are likely to be ineffective or harmful, and tranexamic acid, nimodipine and progesterone show a promising effect in bleeding trauma, traumatic subarachnoid hemorrhage, TBI or severe TBI. (2) A majority of the systematic reviews include a small number of clinical trials and the modest numbers of patients, largely due to the uncertainty of the effectiveness. (3) The quality of most trials reported in the systematic reviews is more or less questionable. (4) In addition, lots of other complex factors together may lead to the inconclusive results demonstrated in the Cochrane Systematic Reviews. Conclusions: For clinical physicians, to translate these conclusions into practice with caution is essential. Basic medication and nursing care deserve additional attention as well and can be beneficial. For researchers, high quality trials with perfect design and comprehensive consideration of various factors are urgently required. PMID:22300914

Lei, Jin; Gao, Guo-Yi; Jiang, Ji-Yao

2012-02-01

158

Search filters to identify geriatric medicine in Medline  

PubMed Central

Objectives To create user-friendly search filters with high sensitivity, specificity, and precision to identify articles on geriatric medicine in Medline. Design A diagnostic test assessment framework was used. A reference set of 2255 articles was created by hand-searching 22 biomedical journals in Medline, and each article was labeled as ‘relevant’, ‘not relevant’, or ‘possibly relevant’ for geriatric medicine. From the relevant articles, search terms were identified to compile different search strategies. The articles retrieved by the various search strategies were compared with articles from the reference set as the index test to create the search filters. Measures Sensitivity, specificity, precision, accuracy, and number-needed-to-read (NNR) were calculated by comparing the results retrieved by the different search strategies with the reference set. Results The most sensitive search filter had a sensitivity of 94.8%, a specificity of 88.7%, a precision of 73.0%, and an accuracy of 90.2%. It had an NNR of 1.37. The most specific search filter had a specificity of 96.6%, a sensitivity of 69.1%, a precision of 86.6%, and an accuracy of 89.9%. It had an NNR of 1.15. Conclusion These geriatric search filters simplify searching for relevant literature and therefore contribute to better evidence-based practice. The filters are useful to both the clinician who wants to find a quick answer to a clinical question and the researcher who wants to find as many relevant articles as possible without retrieving too many irrelevant articles.

van de Glind, Esther M M; van Munster, Barbara C; Spijker, Rene; Scholten, Rob J P M

2011-01-01

159

MedlinePlus 2011 User Survey Results: Which of the following best describes the highest level of education you have ...  

MedlinePLUS

... of education you have completed? (MedlinePlus en español users only) Responses: Graduate/ professional degree MedlinePlus en español users 33% Some college/ vocational school MedlinePlus en español ...

160

GLAD4U: deriving and prioritizing gene lists from PubMed literature  

PubMed Central

Background Answering questions such as "Which genes are related to breast cancer?" usually requires retrieving relevant publications through the PubMed search engine, reading these publications, and creating gene lists. This process is not only time-consuming, but also prone to errors. Results We report GLAD4U (Gene List Automatically Derived For You), a new, free web-based gene retrieval and prioritization tool. GLAD4U takes advantage of existing resources of the NCBI to ensure computational efficiency. The quality of gene lists created by GLAD4U for three Gene Ontology (GO) terms and three disease terms was assessed using corresponding "gold standard" lists curated in public databases. For all queries, GLAD4U gene lists showed very high recall but low precision, leading to low F-measure. As a comparison, EBIMed's recall was consistently lower than GLAD4U, but its precision was higher. To present the most relevant genes at the top of a list, we studied two prioritization methods based on publication count and the hypergeometric test, and compared the ranked lists and those generated by EBIMed to the gold standards. Both GLAD4U methods outperformed EBIMed for all queries based on a variety of quality metrics. Moreover, the hypergeometric method allowed for a better performance by thresholding genes with low scores. In addition, manual examination suggests that many false-positives could be explained by the incompleteness of the gold standards. The GLAD4U user interface accepts any valid queries for PubMed, and its output page displays the ranked gene list and information associated with each gene, chronologically-ordered supporting publications, along with a summary of the run and links for file export and functional enrichment and protein interaction network analysis. Conclusions GLAD4U has a high overall recall. Although precision is generally low, the prioritization methods successfully rank truly relevant genes at the top of the lists to facilitate efficient browsing. GLAD4U is simple to use, and its interface can be found at: http://bioinfo.vanderbilt.edu/glad4u.

2012-01-01

161

Public accessibility of biomedical articles from PubMed Central reduces journal readership--retrospective cohort analysis  

PubMed Central

Does PubMed Central—a government-run digital archive of biomedical articles—compete with scientific society journals? A longitudinal, retrospective cohort analysis of 13,223 articles (5999 treatment, 7224 control) published in 14 society-run biomedical research journals in nutrition, experimental biology, physiology, and radiology between February 2008 and January 2011 reveals a 21.4% reduction in full-text hypertext markup language (HTML) article downloads and a 13.8% reduction in portable document format (PDF) article downloads from the journals' websites when U.S. National Institutes of Health-sponsored articles (treatment) become freely available from the PubMed Central repository. In addition, the effect of PubMed Central on reducing PDF article downloads is increasing over time, growing at a rate of 1.6% per year. There was no longitudinal effect for full-text HTML downloads. While PubMed Central may be providing complementary access to readers traditionally underserved by scientific journals, the loss of article readership from the journal website may weaken the ability of the journal to build communities of interest around research papers, impede the communication of news and events to scientific society members and journal readers, and reduce the perceived value of the journal to institutional subscribers.—Davis, P. M. Public accessibility of biomedical articles from PubMed Central reduces journal readership—retrospective cohort analysis.

Davis, Philip M.

2013-01-01

162

Surgery, with or without tamoxifen, vs tamoxifen alone for older women with operable breast cancer: Cochrane review  

Microsoft Academic Search

The published literature comparing surgery, with or without adjuvant endocrine therapy, with endocrine therapy alone in older women with operable breast cancer was systematically reviewed. The design used is Cochrane review. Randomised controlled trials retrieved from the Cochrane Breast Cancer Group Specialised Register on 29 June 2005. Eligible studies recruited women aged 70 years or over with operable breast cancer,

D Hind; L Wyld; M W Reed

2007-01-01

163

Coadjuvant analgesics for cancer pain: using the clinical queries PubMed tool.  

PubMed

Coadjuvants for cancer pain are medications that, when added to opioids, can potentially decrease narcotic request and opioid-related side effects. Our goal was to review not only the evidence that supports the effectiveness, but also the mechanisms of action of these drugs. We performed a qualitative review using the PubMed database applying the clinical queries tool to identify therapeutic clinical trials or systematic reviews evaluating cancer pain--oral or transdermal--analgesia. We excluded studies using anti-inflammatories, steroids or narcotics as primary analgesia and studies focused on perioperative cancer pain. We supplemented the information describing the mechanisms of action and suggested dosage schemes. We found a qualitative systematic review evaluating ketamine, and randomized trials supporting the use of amitriptyline, gabapentin and transdermal nitroglycerin. We also found some negative trials using gabapentin and lamotrigine for neuropathic pain secondary to chemotherapy. Weak evidence supports intravenous magnesium and lidocaine for breakthrough cancer pain. Further primary research based on clinical trials is required to support some adjuvant analgesics for cancer pain. PMID:20478123

Chaparro Gómez, Luis Enrique; Calvache España, José Andrés; Arbeláez León, Lina Marcela

164

Sex Disparity in Food Allergy: Evidence from the PubMed Database  

PubMed Central

Food allergies are potentially fatal immune-mediated disorders that are growing globally. The relationship between sex and food allergy remains incompletely understood. Here we tested the hypothesis that, should sex influence the clinical response to food allergens, this would be reflected by a sex disparity in published studies of food allergy. We performed a systematic search of the PubMed literature for IgE-mediated allergy to 11 allergenic foods of international regulatory importance. No date restriction was used and only articles in English were considered. Of the 4744 articles retrieved, 591 met the inclusion criteria representing 17528 subjects with food allergies. Whereas among children with food allergies, 64.35% were males and 35.65% were females (male/female ratio, 1.80), among adults 34.82% were males and 65.18% were females (male/female ratio, 0.53). Consequently, these data argue that there is need for further investigation to define the role of sex in the pathogenesis of food allergy.

Kelly, Caleb; Gangur, Venu

2009-01-01

165

Searching PubMed for molecular epidemiology studies: the case of chromosome aberrations.  

PubMed

The available tools for searching literature in the field of Molecular Epidemiology are largely unsatisfactory. To identify major problems in retrieving information on this discipline, we comment here on the results of a literature search on cytogenetic biomarkers in children exposed to environmental pollutants. The search, done on the PubMed/MedLine database, was based on a strategy combining descriptors listed in the PubMed Medical Subject Headings (MeSH) Thesaurus and other available tools (free text or phrase search tools). 178 articles were retrieved by searching the period from January 1, 1980 to November 30, 2004. Only 2 of the 178 articles were indexed by the MeSH term "Epidemiology, molecular" (introduced in 1994) and 30 of 178 by the MeSH term "Biological markers" (introduced in 1989). The case of chromosome aberration (CA) was emblematic of the problem: 44 of 78 articles (56.4%) were not pertinent to the search. The reasons for this poor performance are reported and discussed. Authors and indexers may be able to improve the efficiency of article retrieval in the field of molecular epidemiology by using relevant terms in the title and abstract. This may suggest appropriate MeSH terms to the indexers for the indexing process. As regards the difficulty in identifying population studies using CA, the introduction of a specific MeSH term for chromosome aberrations when used as a biomarker would improve the search process. PMID:16416429

Ugolini, Donatella; Neri, Monica; Knudsen, Lisbeth E; Bonassi, Stefano; Merlo, Domenico Franco

2006-05-01

166

[Primary prevention for alcohol misuse in young people: a Cochrane Systematic Review].  

PubMed

The Cochrane Collaboration is an international no-profit organization established in 1992 in UK. The aim of the Collaboration is the conduction, update and dissemination of systematic reviews about health care. Systematic reviews are electronic documents systematically updated which synthesise the results of randomized controlled studies about treatments. The Cochrane Group on Drugs and Alcohol has the editorial base in Rome (Department of Epidemiology ASL RME) where the Coordinator, the Coordinating Editor and the Trial Search Coordinator, coordinate the work of seven editors based in several countries. As of April 2003 we published 17 reviews and 11 protocols of review. The systematic reviews on primary prevention for alcohol misuse in young people, was conducted by David Foxcroft and published by the group in 2002. The objectives of the systematic review were the identification and synthesis of the studies on psychosocial and educational programs for prevention of alcohol abuse and the assessment of long term interventions (over three years). PMID:15269452

Ferri, Marica

2004-01-01

167

Global priority setting for Cochrane systematic reviews of health promotion and public health research  

PubMed Central

Background: Systematic reviews of health promotion and public health interventions are increasingly being conducted to assist public policy decision making. Many intra-country initiatives have been established to conduct systematic reviews in their relevant public health areas. The Cochrane Collaboration, an international organisation established to conduct and publish systematic reviews of healthcare interventions, is committed to high quality reviews that are regularly updated, published electronically, and meeting the needs of the consumers. Aims: To identify global priorities for Cochrane systematic reviews of public health topics. Methods: Systematic reviews of public health interventions were identified and mapped against global health risks. Global health organisations were engaged and nominated policy-urgent titles, evidence based selection criteria were applied to set priorities. Results: 26 priority systematic review titles were identified, addressing interventions such as community building activities, pre-natal and early infancy psychosocial outcomes, and improving the nutrition status of refugee and displaced populations. Discussion: The 26 priority titles provide an opportunity for potential reviewers and indeed, the Cochrane Collaboration as a whole, to address the previously unmet needs of global health policy and research agencies.

Doyle, J; Waters, E; Yach, D; McQueen, D; De Francisco, A; Stewart, T; Reddy, P; Gulmezoglu, A; Galea, G; Portela, A

2005-01-01

168

PCorral--interactive mining of protein interactions from MEDLINE  

PubMed Central

The extraction of information from the scientific literature is a complex task—for researchers doing manual curation and for automatic text processing solutions. The identification of protein–protein interactions (PPIs) requires the extraction of protein named entities and their relations. Semi-automatic interactive support is one approach to combine both solutions for efficient working processes to generate reliable database content. In principle, the extraction of PPIs can be achieved with different methods that can be combined to deliver high precision and/or high recall results in different combinations at the same time. Interactive use can be achieved, if the analytical methods are fast enough to process the retrieved documents. PCorral provides interactive mining of PPIs from the scientific literature allowing curators to skim MEDLINE for PPIs at low overheads. The keyword query to PCorral steers the selection of documents, and the subsequent text analysis generates high recall and high precision results for the curator. The underlying components of PCorral process the documents on-the-fly and are available, as well, as web service from the Whatizit infrastructure. The human interface summarizes the identified PPI results, and the involved entities are linked to relevant resources and databases. Altogether, PCorral serves curator at both the beginning and the end of the curation workflow for information retrieval and information extraction. Database URL: http://www.ebi.ac.uk/Rebholz-srv/pcorral.

Li, Chen; Arregui, Miguel; Kirsch, Harald; Rebholz-Schuhmann, Dietrich

2013-01-01

169

The effect of feature representation on MEDLINE document classification.  

PubMed

This work explores the effect of text representation techniques on the overall performance of medical text classification. To accomplish this goal, we developed a text classification system that supports the very basic word representation (bag-of-words) and the more complex medical phrase representation (bag-of-phrases). We also combined word and phrase representations (hybrid) for further analysis. Our system extracts medical phrases from text by incorporating a medical knowledge base and natural language processing techniques. We conducted experiments to evaluate the effects of different representations by measuring the change in classification performance with MEDLINE documents from the OHSUMED dataset. We measured classification performance with information retrieval metrics; precision (p), recall (r), and F1-score (F1). In our experiments, we achieved better classification performance with the hybrid approach (p=0.87, r=0.46, F1=0.60) compared to the bag-of-words approach (p=0.85, r=0.44, F1=0.58) and the bag-of-phrases approach (p=0.87, r=0.42, F1=0.57). PMID:16779160

Yetisgen-Yildiz, Meliha; Pratt, Wanda

2005-01-01

170

Shifting Sands: Science Researchers on Google Scholar, Web of Science, and PubMed, with Implications for Library Collections Budgets  

ERIC Educational Resources Information Center

Science researchers at the University of California Santa Cruz were surveyed about their article database use and preferences in order to inform collection budget choices. Web of Science was the single most used database, selected by 41.6%. Statistically there was no difference between PubMed (21.5%) and Google Scholar (18.7%) as the second most…

Hightower, Christy; Caldwell, Christy

2010-01-01

171

Combining PubMed Knowledge and EHR Data to Develop a Weighted Bayesian Network for Pancreatic Cancer Prediction  

PubMed Central

In this paper, we propose a novel method that combines PubMed knowledge and Electronic Health Records to develop a weighted Bayesian Network Inference (BNI) model for pancreatic cancer prediction. We selected 20 common risk factors associated with pancreatic cancer and used PubMed knowledge to weigh the risk factors. A keyword-based algorithm was developed to extract and classify PubMed abstracts into three categories that represented positive, negative, or neutral associations between each risk factor and pancreatic cancer. Then we designed a weighted BNI model by adding the normalized weights into a conventional BNI model. We used this model to extract the EHR values for patients with or without pancreatic cancer, which then enabled us to calculate the prior probabilities for the 20 risk factors in the BNI. The software iDiagnosis was designed to use this weighted BNI model for predicting pancreatic cancer. In an evaluation using a case-control dataset, the weighted BNI model significantly outperformed the conventional BNI and two other classifiers (k-Nearest Neighbor and Support Vector Machine). We conclude that the weighted BNI using PubMed knowledge and EHR data shows remarkable accuracy improvement over existing representative methods for pancreatic cancer prediction.

Zhao, Di; Weng, Chunhua

2011-01-01

172

Public accessibility of biomedical articles from PubMed Central reduces journal readership--retrospective cohort analysis.  

PubMed

Does PubMed Central--a government-run digital archive of biomedical articles--compete with scientific society journals? A longitudinal, retrospective cohort analysis of 13,223 articles (5999 treatment, 7224 control) published in 14 society-run biomedical research journals in nutrition, experimental biology, physiology, and radiology between February 2008 and January 2011 reveals a 21.4% reduction in full-text hypertext markup language (HTML) article downloads and a 13.8% reduction in portable document format (PDF) article downloads from the journals' websites when U.S. National Institutes of Health-sponsored articles (treatment) become freely available from the PubMed Central repository. In addition, the effect of PubMed Central on reducing PDF article downloads is increasing over time, growing at a rate of 1.6% per year. There was no longitudinal effect for full-text HTML downloads. While PubMed Central may be providing complementary access to readers traditionally underserved by scientific journals, the loss of article readership from the journal website may weaken the ability of the journal to build communities of interest around research papers, impede the communication of news and events to scientific society members and journal readers, and reduce the perceived value of the journal to institutional subscribers. PMID:23554455

Davis, Philip M

2013-04-03

173

Shifting Sands: Science Researchers on Google Scholar, Web of Science, and PubMed, with Implications for Library Collections Budgets  

ERIC Educational Resources Information Center

|Science researchers at the University of California Santa Cruz were surveyed about their article database use and preferences in order to inform collection budget choices. Web of Science was the single most used database, selected by 41.6%. Statistically there was no difference between PubMed (21.5%) and Google Scholar (18.7%) as the second most…

Hightower, Christy; Caldwell, Christy

2010-01-01

174

Cost-Effectiveness of Complementary Therapies in the United Kingdom—A Systematic Review  

Microsoft Academic Search

Objectives: The aim of this review is to systematically summarize and assess all prospective, controlled, cost-effectiveness studies of complementary therapies carried out in the UK. Data sources: Medline (via PubMed), Embase, CINAHL, Amed (Alternative and Allied Medicine Database, British Library Medical Information Centre), The Cochrane Library, National Health Service Economic Evaluation Database (via Cochrane) and Health Technology Assessments up to

Peter H. Canter; Joanna Thompson Coon; Edzard Ernst; Exeter Devon

2006-01-01

175

Mentoring programs for medical students - a review of the PubMed literature 2000 - 2008  

PubMed Central

Background Although mentoring is acknowledged as a key to successful and satisfying careers in medicine, formal mentoring programs for medical students are lacking in most countries. Within the framework of planning a mentoring program for medical students at Zurich University, an investigation was carried out into what types of programs exist, what the objectives pursued by such programs are, and what effects are reported. Methods A PubMed literature search was conducted for 2000 - 2008 using the following keywords or their combinations: mentoring, mentoring program, medical student, mentor, mentee, protégé, mentorship. Although a total of 438 publications were identified, only 25 papers met the selection criteria for structured programs and student mentoring surveys. Results The mentoring programs reported in 14 papers aim to provide career counseling, develop professionalism, increase students' interest in research, and support them in their personal growth. There are both one-to-one and group mentorships, established in the first two years of medical school and continuing through graduation. The personal student-faculty relationship is important in that it helps students to feel that they are benefiting from individual advice and encourages them to give more thought to their career choices. Other benefits are an increase in research productivity and improved medical school performance in general. Mentored students also rate their overall well-being as higher. - The 11 surveys address the requirements for being an effective mentor as well as a successful mentee. A mentor should empower and encourage the mentee, be a role model, build a professional network, and assist in the mentee's personal development. A mentee should set agendas, follow through, accept criticism, and be able to assess performance and the benefits derived from the mentoring relationship. Conclusion Mentoring is obviously an important career advancement tool for medical students. In Europe, more mentoring programs should be developed, but would need to be rigorously assessed based on evidence of their value in terms of both their impact on the career paths of juniors and their benefit for the mentors. Medical schools could then be monitored with respect to the provision of mentorships as a quality characteristic.

2010-01-01

176

How useful are systematic reviews for informing palliative care practice? Survey of 25 Cochrane systematic reviews  

PubMed Central

Background In contemporary medical research, randomised controlled trials are seen as the gold standard for establishing treatment effects where it is ethical and practical to conduct them. In palliative care such trials are often impractical, unethical, or extremely difficult, with multiple methodological problems. We review the utility of Cochrane reviews in informing palliative care practice. Methods Published reviews in palliative care registered with the Cochrane Pain, Palliative and Supportive Care Group as of December 2007 were obtained from the Cochrane Database of Systematic Reviews, issue 1, 2008. We reviewed the quality and quantity of primary studies available for each review, assessed the quality of the review process, and judged the strength of the evidence presented. There was no prior intention to perform any statistical analyses. Results 25 published systematic reviews were identified. Numbers of included trials ranged from none to 54. Within each review, included trials were heterogeneous with respect to patients, interventions, and outcomes, and the number of patients contributing to any single analysis was generally much lower than the total included in the review. A variety of tools were used to assess trial quality; seven reviews did not use this information to exclude low quality studies, weight analyses, or perform sensitivity analysis for effect of low quality. Authors indicated that there were frequently major problems with the primary studies, individually or in aggregate. Our judgment was that the reviewing process was generally good in these reviews, and that conclusions were limited by the number, size, quality and validity of the primary studies. We judged the evidence about 23 of the 25 interventions to be weak. Two reviews had stronger evidence, but with limitations due to methodological heterogeneity or definition of outcomes. No review provided strong evidence of no effect. Conclusion Cochrane reviews in palliative care are well performed, but fail to provide good evidence for clinical practice because the primary studies are few in number, small, clinically heterogeneous, and of poor quality and external validity. They are useful in highlighting the weakness of the evidence base and problems in performing trials in palliative care.

Wee, Bee; Hadley, Gina; Derry, Sheena

2008-01-01

177

[From the Cochrane Library: the use of peer review is still under discussion].  

PubMed

Peer review is generally considered to be an invaluable part of the editorial process of biomedical journals. It is widely assumed that peer review has positive effects on the quality of submitted papers and of biomedical research. This is why improvements in peer reviewing have been studied for some years. According to the authors of a recent Cochrane methodology review, peer review does improve the quality of papers, but there is insufficient evidence that it also improves the quality of biomedical research. A major study on this subject is called for, since its results could have implications for patient care and scientific research. PMID:18561790

Stijntjes, F; Veeken, H

2008-04-19

178

Healthcare Inspection Hemodialysis Nursing Care Issues at the John Cochran Division St. Louis VA Medical Center St. Louis, Missouri.  

National Technical Information Service (NTIS)

The VA Office of Inspector General Office of Healthcare Inspections conducted an inspection to determine the validity of allegations regarding nursing care issues in the hemodialysis (HD) unit of the John Cochran Division of the St. Louis VA Medical Cente...

2012-01-01

179

MedlinePlus FAQ: Can I download a tutorial to use on my computer?  

MedlinePLUS

... Medicine National Institutes of Health Home About MedlinePlus Site Map FAQs Contact Us Search MedlinePlus Health Topics Drugs & Supplements Videos & Cool Tools ESPAÑOL Question: Can I download a tutorial to use on my computer? To use the sharing features on this page, ...

180

MedlinePlus 2011 User Survey Results: Please select the category that includes your age  

MedlinePLUS

... features on this page, please enable JavaScript. 2011 User Survey Results: Slide Index | Previous | Next Please select ... that includes your age. Responses: 45-54 MedlinePlus users 23% MedlinePlus en español users 22% 55-59 ...

181

Online Medline plus Fan Search V Offsearch: A Comparison of Literature Retrieval Methods  

Microsoft Academic Search

Medline is a computerized indexing and abstracting service for biomedical literature and is one of the most commonly used methods of literature retrieval. An alternative manual technique is fan searching. Fan searching involves scanning bibliographies of relevant articles from online Medline searches of the most current literature. We compared the amount of relevant literature retrieval between these two methods. We

Dennis F. Thompson; Mary Lee

1986-01-01

182

Extracts from The Cochrane Library: Topical anaesthetic or vasoconstrictor preparations for flexible fibre-optic nasal pharyngoscopy and laryngoscopy.  

PubMed

The "Cochrane Corner" is a quarterly section in the Journal that highlights systematic reviews relevant to otolaryngology- head and neck surgery, with invited commentary to aid clinical decision making. This installment features a Cochrane Review, "Topical Anaesthetic or Vasoconstrictor Preparations for Flexible Fibre-optic Nasal Pharyngoscopy and Laryngoscopy," that finds no evidence of reduced pain or discomfort for topical treatment prior to endoscopy. PMID:22492360

Burton, Martin J; Altman, Kenneth W; Rosenfeld, Richard M

2012-04-09

183

Extracts from The Cochrane Library: Erythropoietin as an adjuvant treatment with (chemo) radiation therapy for head and neck cancer.  

PubMed

The "Cochrane Corner" is a quarterly section in the Journal that highlights systematic reviews relevant to otolaryngology-head and neck surgery, with invited commentary to aid clinical decision making. This installment features a Cochrane Review entitled "Erythropoietin as an adjuvant treatment with (chemo) radiation therapy for head and neck cancer," which concludes that erythropoietin should not be administered as an addition to radiation therapy outside the experimental setting. PMID:19786209

Burton, Martin J; Deschler, Daniel G; Rosenfeld, Richard M

2009-10-01

184

Extracts from the Cochrane Library: "Grommets (ventilation tubes) for hearing loss associated with otitis media with effusion in children".  

PubMed

The Cochrane Corner is a quarterly section in the journal that highlights systematic reviews relevant to otolaryngology–head and neck surgery, with invited commentary to aid clinical decision making. This installment features an updated Cochrane review "Grommets (Ventilation Tubes) for Hearing Loss Associated with Otitis Media with Effusion in Children" that reinforces the modest benefits demonstrated in the original review published in 2005. PMID:21493258

Burton, Martin J; Derkay, Craig S; Rosenfeld, Richard M

2011-05-01

185

Skeletal and Dental Changes in Class II division 1 Malocclusions Treated with Splint-Type Herbst Appliances A Systematic Review  

Microsoft Academic Search

Objective: To evaluate skeletal and dental changes in growing individuals through lateral ceph- alograms obtained after the sole use of the splint-type Herbst appliances in Class II division 1 malocclusions. Methods: Several electronic databases (Pubmed, Medline, Medline In-Process & Other Non- Indexed Citations, Cochrane Library Database, Embase, Web of Sciences, Scopus, and Lilacs) were searched with the help of a

Carlos Flores-Mir; Abenaa Ayeh; Ashim Goswani

186

Subject expertise among MEDLINE searchers: results of a survey and analysis of job openings.  

PubMed Central

To determine the current demand for subject expertise among MEDLINE searchers, position announcements in the MLA News from January, 1981 to September, 1982 were examined. Of 125 reference/search analyst positions listed, 63 (50%) required or preferred a health sciences or related subject background. To ascertain how well the current medical library search analyst workforce meets these requirements of expertise 111 MEDLINE searchers were surveyed. Participants were queried as to the type of institution in which they were currently employed, searching experience, searching workload, educational background, and value placed on subject expertise in online searching. Differences were noted among the responses of hospital, academic health sciences, and corporate MEDLINE searchers.

Glasgow, V L; Foreman, G

1984-01-01

187

Proper manual handling techniques to prevent low back pain, a Cochrane systematic review.  

PubMed

Training and provision of assistive devices are considered major interventions to prevent and treat low back pain (LBP) among workers exposed to manual material handling (MMH). To establish the effectiveness of training and provision of assistive devices in preventing and treating LBP an update of a Cochrane literature review was performed to November 2010. Randomised controlled trials (RCTs) and cohort studies with a concurrent control group (CCTs) were included. Nine RCTs (20.101 employees) and nine CCTs (1280 employees) were included for prevention: six more than in the previous version. No study on treatment was found. None of the included RCTs and CCTs provided evidence that training and provision of assistive devices prevented LBP when compared to no intervention or another intervention. PMID:22317058

Verbeek, Jos H; Martimo, Kari-Pekka; Kuijer, P Paul F M; Karppinen, Jaro; Viikari-Juntura, Eira; Takala, Esa-Pekka

2012-01-01

188

Concordance of Adherence Measurement Using Self-Reported Adherence Questionnaires and Medication Monitoring Devices  

Microsoft Academic Search

The primary objective of this review was to identify and examine the literature on the association between medication adherence self-reported questionnaires (SRQs) and medication monitoring devices. The primary literature search was performed for 1980-2009 using PubMed, PubMed In Process and Non-Indexed, Ovid MEDLINE, Ovid MEDLINE In-Process, PsycINFO (EBSCO), CINAHL (EBSCO), Ovid HealthStar, EMBASE (Elsevier) and Cochrane Databases and using the

Lizheng Shi; Jinan Liu; Yordanka Koleva; Vivian Fonseca; Anupama Kalsekar; Manjiri Pawaskar

2010-01-01

189

For Distinguished Public Service: Medical Library Association Honors FNLM and NIH MedlinePlus Magazine | NIH ...  

MedlinePLUS

... turn Javascript on. For Distinguished Public Service: Medical Library Association Honors FNLM and NIH MedlinePlus Magazine Past ... hearing from you. The Friends of the National Library of Medicine has a warm and mutually appreciative ...

190

Globetrotting to a Good Night's Sleep | NIH MedlinePlus the Magazine  

MedlinePLUS

... is one of the most common and troubling sleep disorders. At least 1 in 10 older adults, and ... have sleep apnea. To Find Out More MedlinePlus Sleep Disorders www.nlm.nih.gov/medlineplus/sleepdisorders.html NHLBI ...

191

Skater Tara Lipinski Speaks Out About DVT | NIH MedlinePlus the Magazine  

MedlinePLUS

... and block blood flow. This condition is called pulmonary embolism (PE). PE is a very serious condition that ... www.nlm.nih.gov/medlineplus/deepveinthrombosis.html MedlinePlus: Pulmonary Embolism www.nlm.nih.gov/medlineplus/pulmonaryembolism.html National ...

192

A Two-Term MEDLINE Search Strategy for Identifying Randomized Trials in Obstetrics and Gynecology  

Microsoft Academic Search

Objective: To develop and test a simple MEDLINE search strategy for identification of randomized controlled trials (RCTs) in obstetrics and gynecology.Methods: To develop our search strategy, we asked clinicians in our department to indicate, from a list of search terms, the terms they would use to identify RCTs in MEDLINE. The two most common terms, controlled-clinical-trial (publication type) and randomized-controlled-trial

Chika R Nwosu; Khalid S Khan; Patrick F. W Chien

1998-01-01

193

Future horizons in vitiligo research: focusing on the recommendations of the Cochrane systematic review 'Interventions for vitiligo' 2010.  

PubMed

The 'Implications for research' section of the Cochrane systematic review, 'Interventions for vitiligo', published in 2010, highlighted three main issues that impact the standard of vitiligo research: (i) lack of consensus on the classification and definition of vitiligo; (ii) lack of consensus on the methods of assessment and outcome measures for vitiligo; and (iii) heterogeneity of interventions compared. This article provides an update of the progress made to resolve these issues since the publication of the Cochrane systematic review in 2010, 'Interventions for vitiligo'. PMID:24098902

Eleftheriadou, V

2013-10-01

194

Extracts from the Cochrane Library: modifications of the Epley (canalith repositioning) maneuver for posterior canal benign paroxysmal positional vertigo.  

PubMed

The "Cochrane Corner" is a quarterly section in the Journal that highlights systematic reviews relevant to otolaryngology-head and neck surgery, with invited commentary to aid clinical decision making. This installment features a Cochrane review "Modifications of the Epley (Canalith Repositioning) Manoeuvre for Posterior Canal Benign Paroxysmal Positional Vertigo (BPPV)" that finds no evidence of benefit for mastoid oscillation applied during the Epley maneuver nor any clinically important benefit for post-Epley postural restrictions in comparison with the Epley maneuver alone. PMID:22886077

Burton, Martin J; Eby, Thomas L; Rosenfeld, Richard M

2012-08-11

195

Evaluating the impact of MEDLINE filters on evidence retrieval: study protocol  

PubMed Central

Background Rather than searching the entire MEDLINE database, clinicians can perform searches on a filtered set of articles where relevant information is more likely to be found. Members of our team previously developed two types of MEDLINE filters. The 'methods' filters help identify clinical research of high methodological merit. The 'content' filters help identify articles in the discipline of renal medicine. We will now test the utility of these filters for physician MEDLINE searching. Hypothesis When a physician searches MEDLINE, we hypothesize the use of filters will increase the number of relevant articles retrieved (increase 'recall,' also called sensitivity) and decrease the number of non-relevant articles retrieved (increase 'precision,' also called positive predictive value), compared to the performance of a physician's search unaided by filters. Methods We will survey a random sample of 100 nephrologists in Canada to obtain the MEDLINE search that they would first perform themselves for a focused clinical question. Each question we provide to a nephrologist will be based on the topic of a recently published, well-conducted systematic review. We will examine the performance of a physician's unaided MEDLINE search. We will then apply a total of eight filter combinations to the search (filters used in isolation or in combination). We will calculate the recall and precision of each search. The filter combinations that most improve on unaided physician searches will be identified and characterized. Discussion If these filters improve search performance, physicians will be able to search MEDLINE for renal evidence more effectively, in less time, and with less frustration. Additionally, our methodology can be used as a proof of concept for the evaluation of search filters in other disciplines.

2010-01-01

196

Hand searching the Journal of Epidemiology and Community Health as part of th Cochrane Collaboration.  

PubMed Central

STUDY OBJECTIVE: To identify randomised controlled trials (RCTs) published in the Journal of Epidemiology and Community Health and to explore the contribution of these to the evaluation of public health issues. DESIGN: Hand searching of the journal by both authors with independent assessment of topics of the reports and of their relevance to the Cochrane Collaboration. Agreement was assessed using kappa scores. SETTING: All papers and letters published in the journal from the first issue to the end of 1994. SUBJECTS: Reports that might be RCTs were collected and classified into seven categories: definitely/probably/possibly RCTs or quasi-RCTs; or none of these. MAIN RESULTS: Eighty two definite RCTs were identified and a further 23 were probably/possibly RCTs or quasi-RCTs. Most reports dealt with health education, drug treatments, or "other" health service interventions. Both authors failed to identify a number of trials on hand searching. CONCLUSIONS: The journal has published many trials of importance to the development of evidence-based public health policy. Hand searching may need to be done independently by more than one person.

Milne, R; Thorogood, M

1996-01-01

197

Healthcare Inspection: Quality of Care Provided by a Nurse, John Cochran Division, St. Louis VA Medical Center, St. Louis, Missouri.  

National Technical Information Service (NTIS)

The VA Office of Inspector General Office of Healthcare Inspections conducted an inspection to determine the validity of allegations regarding the quality of care provided by a nurse at the John Cochran Division, St. Louis VA Medical Center, St. Louis, MO...

2012-01-01

198

Using Cochran's Z Statistic to Test the Kernel-Smoothed Item Response Function Differences between Focal and Reference Groups  

ERIC Educational Resources Information Center

This study combined the kernel smoothing procedure and a nonparametric differential item functioning statistic--Cochran's Z--to statistically test the difference between the kernel-smoothed item response functions for reference and focal groups. Simulation studies were conducted to investigate the Type I error and power of the proposed…

Zheng, Yinggan; Gierl, Mark J.; Cui, Ying

2010-01-01

199

Pilot study optimizing MEDLINE queries in an automated disease management telemedicine system.  

PubMed Central

Clinicians encounter many medical questions while providing outpatient medical care. A significant number of these questions can be answered using MEDLINE; however it has proven to be difficult to incorporate MEDLINE into routine clinical workflow and for clinicians to generate well constructed MEDLINE queries. This study however hypothesized that that well-constructed MEDLINE queries could be semi-automatically generated by an application named LitButton which was incorporated into the TeleWatch telemedicine system. The LitButton application was then prospectively evaluated in a pilot study by four nurse case managers (NCM) who monitored sixty-eight outpatients for three weeks. During this period the NCMs used the LitButton application sixteen times, and they subjectively reported in real-time that they obtained an answer in 56% of the cases, but that none of the successful information retrieval events resulted in a change in a patient's clinical management. The small number of LitButton events and lack of clinical impact was likely due to the fact that the LitButton function was designed to search MEDLINE for treatment related information; however the NCMs had limited medical decision making responsibilities. As a result there was a mismatch between the user's information needs and the system capabilities.

Spaeder, Jeffrey A.

2002-01-01

200

Indexing of randomised controlled trials of physiotherapy interventions: a comparison of AMED, CENTRAL, CINAHL, EMBASE, Hooked on Evidence, PEDro, PsycINFO and PubMed  

Microsoft Academic Search

ObjectiveTo compare the comprehensiveness of indexing the reports of randomised controlled trials of physiotherapy interventions by eight bibliographic databases (AMED, CENTRAL, CINAHL, EMBASE, Hooked on Evidence, PEDro, PsycINFO and PubMed).

Anne M. Moseley; Catherine Sherrington; Mark R. Elkins; Robert D. Herbert; Christopher G. Maher

2009-01-01

201

Language barriers and bibliographic retrieval effectiveness: use of MEDLINE by French-speaking end users.  

PubMed Central

OBJECTIVE: A study was conducted to determine if bibliographic retrieval performed by French-speaking end users is impaired by English language interfaces. The American database MEDLINE on CD-ROM was used as a model. METHODS: A survey of self-administered questionnaires was performed at two libraries of Victor Segalen Bordeaux 2 University, during a two-month period in 1997. Three study groups were constituted: MEDLINE / Ovid end users, MEDLINE / Ovid librarian-mediated users, and Pascal, a French bibliographic database, end users. RESULTS: Among 191 respondents, only 22% thought English was an obstacle to their bibliographic retrieval. However, the research software was generally underused and the quality of the retrieval weak. The differences were statistically significant between users trained by librarians and the self-trained group, the former performing better. CONCLUSION: Special efforts need to be made to develop curriculum training programs for computerized bibliographic retrieval in medical schools, regardless of the native language of the student.

Mouillet, E

1999-01-01

202

A Drug-Adverse Event Extraction Algorithm to Support Pharmacovigilance Knowledge Mining from PubMed Citations  

PubMed Central

Adverse drug events (ADEs) create a serious problem causing substantial harm to patients. An executable standardized knowledgebase of drug-ADE relations which is publicly available would be valuable so that it could be used for ADE detection. The literature is an important source that could be used to generate a knowledgebase of drug-ADE pairs. In this paper, we report on a method that automatically determines whether a specific adverse event (AE) is caused by a specific drug based on the content of PubMed citations. A drug-ADE classification method was initially developed to detect neutropenia based on a pre-selected set of drugs. This method was then applied to a different set of 76 drugs to determine if they caused neutropenia. For further proof of concept this method was applied to 48 drugs to determine whether they caused another AE, myocardial infarction. Results showed that AUROC was 0.93 and 0.86 respectively.

Wang, Wei; Haerian, Krystl; Salmasian, Hojjat; Harpaz, Rave; Chase, Herbert; Friedman, Carol

2011-01-01

203

Bibliometric Analysis of the Korean Journal of Parasitology: Measured from SCI, PubMed, Scopus, and Synapse Databases  

PubMed Central

The Korean Journal of Parasitology (KJP) is the official journal of the Korean Society for Parasitology which is celebrating its 50th anniversary in 2009. To assess the contributions and achievements of the KJP, bibliometric analysis was conducted based on the citation data retrieved from 4 major databases; SCI, PubMed, Synapse, and Scopus. It was found that the KJP articles were constantly cited by the articles published in major international journals represented in these databases. More than 60% of 1,370 articles published in the KJP from 1963 to June 2009 were cited at least once by SCI articles. The overall average times cited by SCI articles are 2.6. The rate is almost 3 times higher for the articles published in the last 10 years compared to 1.0 for the articles of the 1960s. The SCI journal impact factor for 2008 is calculated as 0.871. It is increasing and it is expected to increase further with the introduction of the KJP in the database in 2008. The more realistic h-indixes were measured from the study data set covering all the citations to the KJP; 17 for SCI, 6 for PubMed, 19 for Synapse, and 17 for Scopus. Synapse extensively picked up the citations to the earlier papers not retrievable from the other 3 databases. It identified many papers published in the 1960s and in the 1980s which have been cited heavily, proving the central role of the KJP in the dissemination of the important research findings over the last 5 decades.

2009-01-01

204

A study comparing centralized CD-ROM and decentralized intranet access to MEDLINE  

PubMed Central

Objective: The purpose of this study was to evaluate the efficacy of a decentralized intranet access in each medical department as opposed to centralized unique MEDLINE access in the medical library. Design: A two-phase questionnaire to evaluate MEDLINE use was given to junior and senior physicians at Rouen University Hospital (RUH). Phase I (August–October 1996) corresponded to a time period when centralized access was the only means of access available and phase II (August–October 1997) to a time period following the introduction of decentralized intranet access. Results: A total of 168 physicians filled out at least one phase of the questionnaire, among whom 123 (73%) filled out both phases. Use of MEDLINE significantly increased in 1997 (average of 10.2 ± 1.1 searches in three months) versus 1996 (average of 4.9 ± 0.7 searches in three months, P < 0.0001). The aim of searches changed, becoming significantly more care oriented in phase II (P < 0.0001). The number of searches performed by the physicians alone increased (P < 0.0001) and searches performed by the librarian decreased (P < 0.0001) in phase II. The method of searches also changed, as searches by author (P < 0.0001), by journal (P = 0.0042), and by free word (P = 0.0027) increased in phase II. Knowledge of the following concepts of MEDLINE significantly increased: explosion (P < 0.0001), scope note (P < 0.0001), Abridged Index Medicus (AIM) journals (P < 0.0001), Medical Subject Headings (MeSH) qualifier (P < 0.0001), and focus (P < 0.0001). Conclusion: A decentralized intranet access to MEDLINE increased the number of searches and knowledge of this bibliographic database. MEDLINE intranet access modified the purpose and the methods of searching.

Darmoni, Stefan J.; Benichou, Jacques; Thirion, Benoit; Hellot, Marie France; Fuss, Jacques

2000-01-01

205

PubMed Central  

Microsoft Academic Search

Many scientific, technical, and medical publishers today are moving from journal publishing to publishing information resources. This move is based on the Internet, where users have access to the benefits that can be offered with electronic publishing. However, a major problem in the publication process is length of time it can take for actual publication as well as the access

Liz Pope

2001-01-01

206

MEDLINE plus  

Microsoft Academic Search

The Na tional Li brary of Med i cine's MEDLINEplus has come a long way in the past year, and has evolved into a wor thy com pet i -tor to even the best of the com mer cial health por tal sites. This re view will ex am ine the new est de vel op ments on the site

Jennifer Reiswig

2001-01-01

207

Model Formulation: A Document Clustering and Ranking System for Exploring MEDLINE Citations  

Microsoft Academic Search

ObjectiveA major problem faced in biomedical informatics involves how best to present information retrieval results. When a single query retrieves many results, simply showing them as a long list often provides poor overview. With a goal of presenting users with reduced sets of relevant citations, this study developed an approach that retrieved and organized MEDLINE citations into different topical groups

Yongjing Lin; Wenyuan Li; Keke Chen; Ying Liu

2007-01-01

208

Measuring Information through Topical Subheadings of the Medline Database: A Case Study.  

ERIC Educational Resources Information Center

|Describes a method for measuring research information from thematic references such as headings and subheadings that are used in indexing, cataloging, and online searching, using the Rasch model as the measuring instrument. Discusses results of a search of anesthesiology in the Medline database that was used as a case study. (Author/LRW)|

Alvarez, P.; Pulgarin, A.

1999-01-01

209

Comparison of CINAHL, EMBASE, and MEDLINE Databases for the Nurse Researcher  

Microsoft Academic Search

The purpose of this research was to determine which of three databases, CINAHL, EMBASE or MEDLINE, should be accessed when researching nursing topics. The three databases were searched for citations on topics selected by three nurse researchers and the results were compared. For the search of nursing care literature on a medical condition, it was helpful to search both CINAHL

Judy Burnham; Barbara Shearer

1993-01-01

210

Ranking the whole MEDLINE database according to a large training set using text indexing  

Microsoft Academic Search

BACKGROUND: The MEDLINE database contains over 12 million references to scientific literature, with about 3\\/4 of recent articles including an abstract of the publication. Retrieval of entries using queries with keywords is useful for human users that need to obtain small selections. However, particular analyses of the literature or database developments may need the complete ranking of all the references

Brian P. Suomela; Miguel A. Andrade

2005-01-01

211

How to select publications on occupational health: the usefulness of Medline and the impact factor  

Microsoft Academic Search

OBJECTIVESPublications in the field of occupational health appear in various journals, including those of other medical specialties. This complicates the follow up of literature for specialists in this field. On the basis of Medline and the impact factor, this diversity was assessed, and a cost effective method for selecting the most pertinent journals in the practice of occupational health was

J F Gehanno; B. Thirion

2000-01-01

212

Selecting a Database for Drug Literature Retrieval: A Comparison of MEDLINE, Scopus, and Web of Science  

Microsoft Academic Search

Three widely used databases—MEDLINE, Scopus, and Web of Science—were compared for their relative ability to retrieve the largest number of articles within the drug literature, using three search terms: two for specific drugs (atorvastatin and olanzapine) and one for a major class of drugs (statins). These drugs and the class of drugs were chosen for their longevity and continued high

Svetla Baykoucheva

2010-01-01

213

Implicit Text Linkages between Medline Records: Using Arrowsmith as an Aid to Scientific Discovery.  

ERIC Educational Resources Information Center

Addresses the problem of how to find interesting but previously unknown implicit information within the scientific literature. The use of software, called Arrowsmith, that can create suggestive juxtapositions of Medline records to help biomedical researchers detect new and useful relationships, is described. Contains 34 references. (Author/MES)

Swanson, Don R.; Smallheiser, Neil R.

1999-01-01

214

Developing Optimal Search Strategies for Detecting Clinically Sound Causation Studies in MEDLINE  

Microsoft Academic Search

Background: Clinical end users of MEDLINE must be able to retrieve articles that are both scientifically sound and directly relevant to clinical practice. The use of methodologic search filters has been advocated to improve the accuracy of searching for such studies. These filters are available for the literature on therapy and diagnosis, but strategies for the literature on causation have

Nancy L. Wilczynski; R. Brian Haynes

2003-01-01

215

Does Syndrome Differentiation Matter? A Meta-Analysis of Randomized Controlled Trials in Cochrane Reviews of Acupuncture  

PubMed Central

Abstract Background One of the basic and important principles of Traditional Chinese Medicine theory is syndrome differentiation, which is widely utilized for individual diagnosis and in the application of acupuncture treatment. However, the impact of syndrome differentiation on therapeutic effect is unclear because of insufficient supportive clinical evidence. Objective The aim of this study was to analyze current Cochrane Database systematic reviews of acupuncture and to evaluate differences in therapeutic effects of acupuncture treatment when syndrome differentiation is utilized, compared to when this approach is not utilized. Methods Cochrane Database systematic reviews of acupuncture were included if the reviews had sufficient data to perform subgroup analyses by syndrome differentiation applied during acupoints' selection. Searching was conducted across all available articles of the Cochrane Library, and the search concluded in July 2011. Results Forty-four trials from five Cochrane reviews were included in 10 subgroup meta-analyses. Seven meta-analyses showed that there were no differences between trials using fixed acupoints prescriptions and trials using individualized treatment based on relevant symptom improvements in cases of acute stroke, depression, epilepsy, migraine, and peripheral joint osteoarthritis (OA). The remaining 3 meta-analyses showed that acupuncture with fixed prescriptions was superior to individualized acupuncture for pain relief of peripheral joint OA, compared to sham control. Conclusions The available evidence showed no significant difference between acupuncture treatment with or without syndrome differentiation. Large, well-designed trials are warranted to address the use of syndrome differentiation for specific diseases or conditions in order to confirm if there are any advantages of using syndrome differentiation to achieve better therapeutic effects with acupuncture.

Cao, Huijuan; Bourchier, Suzannah

2012-01-01

216

A drug-adverse event extraction algorithm to support pharmacovigilance knowledge mining from PubMed citations.  

PubMed

Adverse drug events (ADEs) create a serious problem causing substantial harm to patients. An executable standardized knowledgebase of drug-ADE relations which is publicly available would be valuable so that it could be used for ADE detection. The literature is an important source that could be used to generate a knowledgebase of drug-ADE pairs. In this paper, we report on a method that automatically determines whether a specific adverse event (AE) is caused by a specific drug based on the content of PubMed citations. A drug-ADE classification method was initially developed to detect neutropenia based on a pre-selected set of drugs. This method was then applied to a different set of 76 drugs to determine if they caused neutropenia. For further proof of concept this method was applied to 48 drugs to determine whether they caused another AE, myocardial infarction. Results showed that AUROC was 0.93 and 0.86 respectively. PMID:22195210

Wang, Wei; Haerian, Krystl; Salmasian, Hojjat; Harpaz, Rave; Chase, Herbert; Friedman, Carol

2011-10-22

217

Biotea: RDFizing PubMed Central in support for the paper as an interface to the Web of Data  

PubMed Central

Background The World Wide Web has become a dissemination platform for scientific and non-scientific publications. However, most of the information remains locked up in discrete documents that are not always interconnected or machine-readable. The connectivity tissue provided by RDF technology has not yet been widely used to support the generation of self-describing, machine-readable documents. Results In this paper, we present our approach to the generation of self-describing machine-readable scholarly documents. We understand the scientific document as an entry point and interface to the Web of Data. We have semantically processed the full-text, open-access subset of PubMed Central. Our RDF model and resulting dataset make extensive use of existing ontologies and semantic enrichment services. We expose our model, services, prototype, and datasets at http://biotea.idiginfo.org/ Conclusions The semantic processing of biomedical literature presented in this paper embeds documents within the Web of Data and facilitates the execution of concept-based queries against the entire digital library. Our approach delivers a flexible and adaptable set of tools for metadata enrichment and semantic processing of biomedical documents. Our model delivers a semantically rich and highly interconnected dataset with self-describing content so that software can make effective use of it.

2013-01-01

218

A qualitative study into the difficulties experienced by healthcare decision makers when reading a Cochrane diagnostic test accuracy review  

PubMed Central

Background Cochrane reviews are one of the best known and most trusted sources of evidence-based information in health care. While steps have been taken to make Cochrane intervention reviews accessible to a diverse readership, little is known about the accessibility of the newcomer to the Cochrane library: diagnostic test accuracy reviews (DTARs). The current qualitative study explored how healthcare decision makers, who varied in their knowledge and experience with test accuracy research and systematic reviews, read and made sense of DTARs. Methods A purposive sample of clinicians, researchers and policy makers (n = 21) took part in a series of think-aloud interviews, using as interview material the first three DTARs published in the Cochrane library. Thematic qualitative analysis of the transcripts was carried out to identify patterns in participants’ ‘reading’ and interpretation of the reviews and the difficulties they encountered. Results Participants unfamiliar with the design and methodology of DTARs found the reviews largely inaccessible and experienced a range of difficulties stemming mainly from the mismatch between background knowledge and level of explanation provided in the text. Experience with systematic reviews of interventions did not guarantee better understanding and, in some cases, led to confusion and misinterpretation. These difficulties were further exacerbated by poor layout and presentation, which affected even those with relatively good knowledge of DTARs and had a negative impact not only on their understanding of the reviews but also on their motivation to engage with the text. Comparison between the readings of the three reviews showed that more accessible presentation, such as presenting the results as natural frequencies, significantly increased participants’ understanding. Conclusions The study demonstrates that authors and editors should pay more attention to the presentation as well as the content of Cochrane DTARs, especially if the reports are aimed at readers with various levels of background knowledge and experience. It also raises the question as to the anticipated target audience of the reports and suggests that different groups of healthcare decision-makers may require different modes of presentation.

2013-01-01

219

Bibliometric assessment of publication output of child and adolescent psychiatric/psychological affiliations between 2005 and 2010 based on the databases PubMed and Scopus.  

PubMed

We aimed to determine the quantitative scientific publication output of child and adolescent psychiatric/psychological affiliations during 2005-2010 by country based on both, "PubMed" and "Scopus" and performed a bibliometric qualitative evaluation for 2009 using "PubMed". We performed our search by affiliation related to child and adolescent psychiatric/psychological institutions using "PubMed". For the quantitative analysis for 2005-2010, we counted the number of abstracts. For the qualitative analysis for 2009 we derived the impact factor of each abstract's journal from "Journal Citation Reports". We related total impact factor scores to the gross domestic product (GDP) and population size of each country. Additionally, we used "Scopus" to determine the number of abstracts for each country that was identified via "PubMed" for 2009 and compared the ranking of countries between the two databases. 61 % of the publications between 2005 and 2010 originated from European countries and 26 % from the USA. After adjustment for GDP and population size, the ranking positions changed in favor of smaller European countries with a population size of less than 20 million inhabitants. The ranking of countries for the count of articles in 2009 as derived from "Scopus" was similar to that identified via the "PubMed" search. The performed search revealed only minor differences between "Scopus" and "PubMed" related to the ranking of countries. Our data indicate a sharp difference between countries with a high versus low GDP with regard to scientific publication output in child and adolescent psychiatry/psychology. PMID:22434265

Albayrak, Ozgür; Föcker, Manuel; Wibker, Katrin; Hebebrand, Johannes

2012-03-21

220

Analysis of the Acceptance Behaviour of Medical Librarians and Their Patrons with Regards to Medline on CD-ROM.  

ERIC Educational Resources Information Center

Two questionnaires sent to medical librarians and users of the Core Medline/Ebsco CD-ROM disc in the Netherlands gathered data on librarians' attitudes toward the various forms in which Medline is offered--i.e., printed, online, and CD-ROM. Tables and graphs present data on product attributes, availability, use, relevance, subjects searched,…

Eger, A. J.

1988-01-01

221

Using Co-Authoring and Cross-Referencing Information for MEDLINE Indexing  

PubMed Central

Due to the large amount of new papers regularly entering the MEDLINE database, there is an ongoing effort to design tools that help indexing this new material. Here we investigate the hypothesis that past indexing information coming from referencing and authoring links can be used for this purpose. Using a JAMA-based subset of MEDLINE, we designed ranking scores which rely on this information; given a new article, the aim of these scores is to build an ordered list of MeSH terms that should be used to index this article. Evaluation measures on an independent, 1000-document data set are given. Comparison with equivalent works shows benefits in recall, F-measure and mean average precision. Moreover, cited articles and authors’ past articles contribute to seven of the top ten ranking features, supporting our hypothesis. Further improvements and extensions to this work are exposed in the conclusion.

Delbecque, Thierry; Zweigenbaum, Pierre

2010-01-01

222

EnzyMiner: automatic identification of protein level mutations and their impact on target enzymes from PubMed abstracts  

PubMed Central

Background A better understanding of the mechanisms of an enzyme's functionality and stability, as well as knowledge and impact of mutations is crucial for researchers working with enzymes. Though, several of the enzymes' databases are currently available, scientific literature still remains at large for up-to-date source of learning the effects of a mutation on an enzyme. However, going through vast amounts of scientific documents to extract the information on desired mutation has always been a time consuming process. In this paper, therefore, we describe an unique method, termed as EnzyMiner, which automatically identifies the PubMed abstracts that contain information on the impact of a protein level mutation on the stability and/or the activity of a given enzyme. Results We present an automated system which identifies the abstracts that contain an amino-acid-level mutation and then classifies them according to the mutation's effect on the enzyme. In the case of mutation identification, MuGeX, an automated mutation-gene extraction system has an accuracy of 93.1% with a 91.5 F-measure. For impact analysis, document classification is performed to identify the abstracts that contain a change in enzyme's stability or activity resulting from the mutation. The system was trained on lipases and tested on amylases with an accuracy of 85%. Conclusion EnzyMiner identifies the abstracts that contain a protein mutation for a given enzyme and checks whether the abstract is related to a disease with the help of information extraction and machine learning techniques. For disease related abstracts, the mutation list and direct links to the abstracts are retrieved from the system and displayed on the Web. For those abstracts that are related to non-diseases, in addition to having the mutation list, the abstracts are also categorized into two groups. These two groups determine whether the mutation has an effect on the enzyme's stability or functionality followed by displaying these on the web.

Yeniterzi, Suveyda; Sezerman, Ugur

2009-01-01

223

Optimal search strategies for detecting health services research studies in MEDLINE  

PubMed Central

Background Evidence from health services research (HSR) is currently thinly spread through many journals, making it difficult for health services researchers, managers and policy-makers to find research on clinical practice guidelines and the appropriateness, process, outcomes, cost and economics of health care services. We undertook to develop and test search terms to retrieve from the MEDLINE database HSR articles meeting minimum quality standards. Methods The retrieval performance of 7445 methodologic search terms and phrases in MEDLINE (the test) were compared with a hand search of the literature (the gold standard) for each issue of 68 journal titles for the year 2000 (a total of 25 936 articles). We determined sensitivity, specificity and precision (the positive predictive value) of the MEDLINE search strategies. Results A majority of the articles that were classified as outcome assessment, but fewer than half of those in the other categories, were considered methodologically acceptable (no methodologic criteria were applied for cost studies). Combining individual search terms to maximize sensitivity, while keeping specificity at 50% or more, led to sensitivities in the range of 88.1% to 100% for several categories (specificities ranged from 52.9% to 97.4%). When terms were combined to maximize specificity while keeping sensitivity at 50% or more, specificities of 88.8% to 99.8% were achieved. When terms were combined to maximize sensitivity and specificity while minimizing the differences between the 2 measurements, most strategies for HSR categories achieved sensitivity and specificity of at least 80%. Interpretation Sensitive and specific search strategies were validated for retrieval of HSR literature from MEDLINE. These strategies have been made available for public use by the US National Library of Medicine at www.nlm.nih.gov/nichsr/hedges/search.html.

Wilczynski, Nancy L.; Haynes, R. Brian; Lavis, John N.; Ramkissoonsingh, Ravi; Arnold-Oatley, Alexandra E.

2004-01-01

224

A Simple and Practical Dictionary-based Approach for Identification of Proteins in Medline Abstracts  

Microsoft Academic Search

ObjectiveThe aim of this study was to develop a practical and efficient protein identification system for biomedical corpora.DesignThe developed system, called ProtScan, utilizes a carefully constructed dictionary of mammalian proteins in conjunction with a specialized tokenization algorithm to identify and tag protein name occurrences in biomedical texts and also takes advantage of Medline “Name-of-Substance” (NOS) annotation. The dictionaries for ProtScan

Sergei Egorov; Anton Yuryev; Nikolai Daraselia

2004-01-01

225

A Performance and Failure Analysis of SAPHIRE with a MEDLINE Test Collection  

Microsoft Academic Search

ObjectiveAssess the performance of the SAPHIRE automated information retrieval system.DesignComparative study of automated and human searching of a MEDLINE test collection.MeasurementsRecall and precision of SAPHIRE were compared with those attributes of novice physicians, expert physicians, and librarians for a test collection of 75 queries and 2,334 citations. Failure analysis assessed the efficacy of the Metathesaurus as a concept vocabulary; the

William R. Hersh; David H. Hickman; R Brian Haynes; K. Ann Mckibbon

1994-01-01

226

Extracting Drug-Drug Interaction Articles from MEDLINE to Improve the Content of Drug Databases  

Microsoft Academic Search

Drug-drug interaction systems exhibit low signal-to- noise ratios because of the amount of clinically in- significant or inaccurate information they contain. MEDLINE represents a respected source of peer- reviewed biomedical citations that potentially might serve as a valuable source of drug-drug interaction information, if relevant articles could be pinpointed effectively and efficiently. We evaluated the classification capability of Support Vector

Stephany Duda; Constantin Aliferis; Randolph Miller

227

Patient safety and systematic reviews: finding papers indexed in MEDLINE, EMBASE and CINAHL  

Microsoft Academic Search

ObjectiveTo develop search strategies for identifying papers on patient safety in MEDLINE, EMBASE and CINAHL.MethodsSix journals were electronically searched for papers on patient safety published between 2000 and 2006. Identified papers were divided into two gold standards: one to build and the other to validate the search strategies. Candidate terms for strategy construction were identified using a word frequency analysis

A. A. Tanon; F. Champagne; A. P. Contandriopoulos; M. P. Pomey; A. Vadeboncoeur; H. Nguyen

2010-01-01

228

Development and Implementation of a Microcomputer-based Multi-user MEDLINE System  

Microsoft Academic Search

The Health Sciences Libraries Consortium, a group of health sciences libraries based in Philadelphia, PA, has implemented a MEDLINE database retrieval system based on the CD Plus PlusNet2 system. The system provides access to the entire MEDLlNE database file through three centralized servers and four distributed servers, and is accessible over the HSLC wide-area network linking all of its members.

Alan C. Simon

1991-01-01

229

Assigning categorical information to Japanese medical terms using MeSH and MEDLINE.  

PubMed

This paper reports on the assigning of MeSH (Medical Subject Headings) categories to Japanese terms in an English-Japanese dictionary using the titles and abstracts of articles indexed in MEDLINE. In a previous study, 30,000 of 80,000 terms in the dictionary were mapped to MeSH terms by normalized comparison. It was reasoned that if the remaining dictionary terms appeared in MEDLINE-indexed articles that are indexed using MeSH terms, then relevancies between the dictionary terms and MeSH terms could be calculated, and thus MeSH categories assigned. This study compares two approaches for calculating the weight matrix. One is the TF*IDF method and the other uses the inner product of two weight matrices. About 20,000 additional dictionary terms were identified in MEDLINE-indexed articles published between 2000 and 2004. The precision and recall of these algorithms were evaluated separately for MeSH terms and non-MeSH terms. Unfortunately, the precision and recall of the algorithms was not good, but this method will help with manual assignment of MeSH categories to dictionary terms. PMID:17911806

Onogi, Yuzo

2007-01-01

230

Combining MEDLINE and publisher data to create parallel corpora for the automatic translation of biomedical text  

PubMed Central

Background Most of the institutional and research information in the biomedical domain is available in the form of English text. Even in countries where English is an official language, such as the United States, language can be a barrier for accessing biomedical information for non-native speakers. Recent progress in machine translation suggests that this technique could help make English texts accessible to speakers of other languages. However, the lack of adequate specialized corpora needed to train statistical models currently limits the quality of automatic translations in the biomedical domain. Results We show how a large-sized parallel corpus can automatically be obtained for the biomedical domain, using the MEDLINE database. The corpus generated in this work comprises article titles obtained from MEDLINE and abstract text automatically retrieved from journal websites, which substantially extends the corpora used in previous work. After assessing the quality of the corpus for two language pairs (English/French and English/Spanish) we use the Moses package to train a statistical machine translation model that outperforms previous models for automatic translation of biomedical text. Conclusions We have built translation data sets in the biomedical domain that can easily be extended to other languages available in MEDLINE. These sets can successfully be applied to train statistical machine translation models. While further progress should be made by incorporating out-of-domain corpora and domain-specific lexicons, we believe that this work improves the automatic translation of biomedical texts.

2013-01-01

231

MedlinePlus and the challenge of low health literacy: findings from the Colonias project*  

PubMed Central

Objective: To explore the potential of a community-based health information outreach project to overcome problems associated with health literacy in low-income Hispanic communities along the Texas-Mexico border. Methods: Using a train-the-trainer approach, community outreach workers known as promotoras were trained by a health information outreach team to search English and Spanish versions of MedlinePlus. These 15 promotoras submitted written examples on a weekly basis of the topics they helped residents explore on MedlinePlus and the ways in which the residents used the information. These weekly reports, along with verbal interviews with promotoras and others in the communities, allowed development of a database of 161 incidents (“stories”) demonstrating how community residents used MedlinePlus. These stories were thematically analyzed to explore how the program benefited participants. Results: The database of stories included examples of community residents becoming better informed about their illnesses, resolving to visit doctors, making decisions about recommended treatments, reducing their anxiety about health conditions, committing to healthy or preventive behavior, and assisting family members. Conclusion: With the help of paraprofessionals like promotoras, community-based health information outreach projects may improve the ability of community residents to understand their health conditions and to participate actively in their health care.

Olney, Cynthia A.; Warner, Debra G.; Reyna, Greysi; Wood, Fred B.; Siegel, Elliot R.

2007-01-01

232

User experiences of evidence-based online resources for health professionals: User testing of The Cochrane Library  

PubMed Central

Background Evidence-based decision making relies on easy access to trustworthy research results. The Cochrane Library is a key source of evidence about the effect of interventions and aims to "promote the accessibility of systematic reviews to anyone wanting to make a decision about health care". We explored how health professionals found, used and experienced The Library, looking at facets of user experience including findability, usability, usefulness, credibility, desirability and value. Methods We carried out 32 one-hour usability tests on participants from Norway and the UK. Participants both browsed freely and attempted to perform individually tailored tasks while "thinking aloud". Sessions were recorded and viewed in real time by researchers. Transcriptions and videos were reviewed by one researcher and one designer. Findings reported here reflect issues receiving a high degree of saturation and that we judge to be critical to the user experience of evidence-based web sites, based on principles for usability heuristics, web guidelines and evidence-based practice. Results Participants had much difficulty locating both the site and its contents. Non-native English speakers were at an extra disadvantage when retrieving relevant documents despite high levels of English-language skills. Many participants displayed feelings of ineptitude, alienation and frustration. Some made serious mistakes in correctly distinguishing between different information types, for instance reviews, review protocols, and individual studies. Although most expressed a high regard for the site's credibility, some later displayed a mistrust of the independence of the information. Others were overconfident, thinking everything on The Cochrane Library site shared the same level of quality approval. Conclusion Paradoxically, The Cochrane Library, established to support easy access to research evidence, has its own problems of accessibility. Health professionals' experiences of this and other evidence-based online resources can be improved by applying existing principles for web usability, prioritizing the development of simple search functionality, emitting "researcher" jargon, consistent marking of site ownership, and clear signposting of different document types and different content quality.

Rosenbaum, Sarah E; Glenton, Claire; Cracknell, Jane

2008-01-01

233

Cochrane Collaboration's Annual International Colloquium (6th). Held in Baltimore, Maryland on October 22-26, 1998. Abstract, Executive Summary and Final Report.  

National Technical Information Service (NTIS)

The Cochrane Collaboration, an interntional, non-profit organization, was founded in October 1993. Its mission is to help clinicians, patients, consumers, and others make well-informed decisions about health by preparing, maintaining, and promoting the ac...

P. P. Dickersin

1998-01-01

234

Oral health and respiratory diseases  

Microsoft Academic Search

Data sourcesRelevant studies were sourced using Ovid Medline (In-Process and Other Non-Indexed Citations, Daily Update and OLDMedline); Cumulative Index to Nursing and Allied Health Literature; Evidence Based Medicine of Cochrane Central Register of Controlled Trials; Cochrane Database of Systematic Reviews; Database of Abstracts of Reviews of Effects; Embase; Health and Psychosocial Instruments; HealthSTAR; International Pharmaceutical Abstracts; PubMed; and Google Scholar.Study

Ian Needleman; Nicholas Hirsch

2007-01-01

235

Do antiviral agents effectively treat Ramsay Hunt syndrome?  

Microsoft Academic Search

Data sourcesThe Cochrane Ear, Nose and Throat Disorders Group Trials Register, the Cochrane Central Register of Controlled Trials, Medline, PubMed, Embase and other relevant databases (Cinhal.LILACS,KoreaMed, IndMed, PakMediNet, theUK Clinical Research Network Portfolio Database (UKCRN), the World Health Organization International Clinical Trials Registry Platform (ICTRP), Google Scholar, NLH ENT & Audiology Specialist Library and the metaRegister of Controlled Trials (mRCT).)

Stephen Porter

2008-01-01

236

Factors Associated with Success in Searching medline and Applying Evidence to Answer Clinical Questions  

PubMed Central

Objectives: This study sought to assess the ability of medical and nurse practitioner students to use medline to obtain evidence for answering clinical questions and to identify factors associated with the successful answering of questions. Methods: A convenience sample of medical and nurse practitioner students was recruited. After completing instruments measuring demographic variables, computer and searching attitudes and experience, and cognitive traits, the subjects were given a brief orientation to medline searching and the techniques of evidence-based medicine. The subjects were then given 5 questions (from a pool of 20) to answer in two sessions using the Ovid medline system and the Oregon Health & Science University library collection. Each question was answered using three possible responses that reflected the quality of the evidence. All actions capable of being logged by the Ovid system were captured. Statistical analysis was performed using a model based on generalized estimating equations. The relevance-based measures of recall and precision were measured by defining end queries and having relevance judgments made by physicians who were not associated with the study. Results: Forty-five medical and 21 nurse practitioner students provided usable answers to 324 questions. The rate of correctness increased from 32.3 to 51.6 percent for medical students and from 31.7 to 34.7 percent for nurse practitioner students. Ability to answer questions correctly was most strongly associated with correctness of the answer before searching, user experience with medline features, the evidence-based medicine question type, and the spatial visualization score. The spatial visualization score showed multi-collinearity with student type (medical vs. nurse practitioner). Medical and nurse practitioner students obtained comparable recall and precision, neither of which was associated with correctness of the answer. Conclusions: Medical and nurse practitioner students in this study were at best moderately successful at answering clinical questions correctly with the assistance of literature searching. The results confirm the importance of evaluating both search ability and the ability to use the resulting information to accomplish a clinical task.

Hersh, William R.; Crabtree, M. Katherine; Hickam, David H.; Sacherek, Lynetta; Friedman, Charles P.; Tidmarsh, Patricia; Mosbaek, Craig; Kraemer, Dale

2002-01-01

237

Extraction of gene-disease relations from Medline using domain dictionaries and machine learning.  

PubMed

We describe a system that extracts disease-gene relations from Medline. We constructed a dictionary for disease and gene names from six public databases and extracted relation candidates by dictionary matching. Since dictionary matching produces a large number of false positives, we developed a method of machine learning-based named entity recognition (NER) to filter out false recognitions of disease/gene names. We found that the performance of relation extraction is heavily dependent upon the performance of NER filtering and that the filtering improves the precision of relation extraction by 26.7% at the cost of a small reduction in recall. PMID:17094223

Chun, Hong-Woo; Tsuruoka, Yoshimasa; Kim, Jin-Dong; Shiba, Rie; Nagata, Naoki; Hishiki, Teruyoshi; Tsujii, Jun'ichi

2006-01-01

238

Survey of individual users of MEDLINE on the NLM system (Summary)  

NASA Astrophysics Data System (ADS)

In the past three years the number of individual health professionals who search with MEDLINE on the NLM system has increased dramatically. It is continuing to grow at the rate of over 200 users per month. In order to provide them with an online information retrieval service that individuals can use easily and effectively, NLM surveyed this growing end-user population by the questionnaire including 35 items such as their demographic characteristics, methods of access to the system, frequency of searching, search purpose, number of citations retrieved, use of information retrieved, and level of satisfaction with current system. This paper describes the results of this survey.

Fukushima, Translated By Isao; Kawano, Koreni

239

Physical Activity Interventions in Adult Populations With Disabilities: A Review  

Microsoft Academic Search

The purpose of this paper was to review the literature of physical activity interventions among adults with disabilities, focusing on interventions designed to increase physical activity. Keyword searches were used to identify articles from Academic Search Complete, CINAHL, Cochrane Library, MEDLINE, Physical Education Index, PsycINFO, PubMed, and SPORTDiscus from 1998 to 2009. Relevant data such as participant characteristics, research designs,

Carlos M. Cervantes; Wendell C. Taylor

2011-01-01

240

Hospitalization Among Medicare-Reimbursed Skilled Home Health Recipients  

Microsoft Academic Search

This article presents a summary and critique of the published empirical evidence between the years 2002 and 2011 regarding rehospitalization among Medicare-reimbursed, skilled home health recipients. The knowledge gained will be applied to a discussion regarding ACH among geriatric home health recipients and areas for future research. The referenced literature in MEDLINE, PubMed and Cochrane databases was searched using combinations

Melissa O’Connor

2012-01-01

241

Frictional Resistance in Self-Ligating Orthodontic Brackets and Conventionally Ligated Brackets  

Microsoft Academic Search

Objective: To compare the amount of expressed frictional resistance between orthodontic self- ligating brackets and conventionally ligated brackets in vitro as reported in the literature. Methods: Several electronic databases (Medline, PubMed, Embase, Cochrane Library, and Web of Science) were searched without limits. In vitro studies that addressed friction of self-ligating brackets compared with conventionally ligated brackets were selected and reviewed.

Sayeh Ehsani; Marie-Alice Mandich; Tarek H. El-Bialy; Carlos Flores-Mir

2009-01-01

242

Physical Activity Measurement Instruments for Children with Cerebral Palsy: A Systematic Review  

ERIC Educational Resources Information Center

Aim: This paper is a systematic review of physical activity measurement instruments for field-based studies involving children with cerebral palsy (CP). Method: Database searches using PubMed Central, MEDLINE, CINAHL Plus, PsycINFO, EMBASE, Cochrane Library, and PEDro located 12 research papers, identifying seven instruments that met the inclusion…

Capio, Catherine M.; Sit, Cindy H. P.; Abernethy, Bruce; Rotor, Esmerita R.

2010-01-01

243

Transvaginal sonographic measurement of cervical length to predict preterm birth in asymptomatic women at increased risk: a systematic review  

Microsoft Academic Search

Objectives To estimate the ability of cervical length mea- sured by transvaginal ultrasonography in asymptomatic high-risk women to predict spontaneous preterm birth. Methods MEDLINE, PubMed, EMBASE and the Cochrane Library were searched for articles published in any language between January 1980 and July 2006, using the keywords 'transvaginal ultrasonography' or ('cervix' and ('ultrasound' or 'ultrasonography' or 'sonog- raphy')); and ('preterm'

J. M. G. Crane; D. Hutchens

2008-01-01

244

A systematic review of cognitive development and child human immunodeficiency virus infection  

Microsoft Academic Search

The objective was to systematically review measures and effects of human immunodeficiency virus (HIV) on neurocognitive outcomes for children. Published studies were identified through the use of electronic databases (Cochrane database, Medline, PubMed, Psychinfo) supplemented by hand searching and coverage of the gray literature. All studies including children with HIV infection, which utilized at least one systematic measure of cognitive

Lorraine Sherr; Joanne Mueller; Rebecca Varrall

2009-01-01

245

Association between Clomiphene Citrate and Visual Disturbances with Special Emphasis on Central Retinal Vein Occlusion: A Review  

Microsoft Academic Search

Objectives: To determine whether clomiphene citrate (CC) can be implicated as a cause for central retinal vein occlusion (CRVO) and other visual disturbances. Methods: For this systematic review, we performed a search of the following databases: PubMed (1976 to November 2009), Medline Plus 2009, Cochrane Library (1996 to November 2009), Google and Google Scholar (1996 to November 2009). Thirty-five relevant

Maria I. Viola; David Meyer; Thinus Kruger

2011-01-01

246

Systematic Reviews of Physical and Rehabilitation Medicine Cochrane Contents. Part 1. Disabilities due to spinal disorders and pain syndromes in adults.  

PubMed

Background: This article is the first in a series presenting the strongest published evidence for physical and rehabilitation medicine (PRM) to date coming from the Cochrane Collaboration. The intent of the series is to stimulate ideas for reviews and research in neglected areas of PRM. Aim: To systematically review the rehabilitation contents of the Cochrane Collaboration on disabilities due to spinal disorders or pain syndromes in adults. Methods: The Cochrane Database of Systematic Reviews was searched at the end of June 2013 for articles relevant for PRM about disabilities resulting from spinal disorders or pain syndromes in adults. Retrieved papers were classified according to the PRM approach: active therapies, which require active participation by patients to achieve treatment goals, and passive treatments, which rely on the application of external forces. The quality of the reviews was checked against the AMSTAR checklist. Results: Reviews on spinal disorders or pain syndromes were found in the Cochrane Back Group (CBG) and in the Pain, Palliative and Supportive Care Group (CPPSCG). Thirty-eight (42.8%) of 89 Cochrane reviews in the CBG and 7 (2.4%) of 293 Cochrane reviews in the CPPSCG were included. All were of high quality (range, 8-11 points out of 11 on the AMSTAR checklist). The contents of the reviews are given in detail. Conclusion: This review presents an overview of the current evidence for PRM in the treatment of disabilities due to spinal disorders or pain syndromes in adults. Within PRM there is ample space for research in the Cochrane Collaboration and for producing original studies (randomized controlled trials [RCTs]). Clinical Rehabilitation Impact. To apply evidence-based clinical practice, clinicians must be familiar with the current best evidence. PMID:24084418

Negrini, S; Imperio, G; Villafañe, J H; Negrini, F; Zaina, F

2013-08-01

247

A performance and failure analysis of SAPHIRE with a MEDLINE test collection.  

PubMed Central

OBJECTIVE: Assess the performance of the SAPHIRE automated information retrieval system. DESIGN: Comparative study of automated and human searching of a MEDLINE test collection. MEASUREMENTS: Recall and precision of SAPHIRE were compared with those attributes of novice physicians, expert physicians, and librarians for a test collection of 75 queries and 2,334 citations. Failure analysis assessed the efficacy of the Metathesaurus as a concept vocabulary; the reasons for retrieval of nonrelevant articles and nonretrieval of relevant articles; and the effect of changing the weighting formula for relevance ranking of retrieved articles. RESULTS: Recall and precision of SAPHIRE were comparable to those of both physician groups, but less than those of librarians. CONCLUSION: The current version of the Metathesaurus, as utilized by SAPHIRE, was unable to represent the conceptual content of one-fourth of physician-generated MEDLINE queries. The most likely cause for retrieval of nonrelevant articles was the presence of some or all of the search terms in the article, with frequencies high enough to lead to retrieval. The most likely cause for nonretrieval of relevant articles was the absence of the actual terms from the query, with synonyms or hierarchically related terms present instead. There were significant variations in performance when SAPHIRE's concept-weighing formulas were modified.

Hersh, W R; Hickam, D H; Haynes, R B; McKibbon, K A

1994-01-01

248

Automatic identification of comparative effectiveness research from medline citations to support clinicians' treatment information needs.  

PubMed

Online knowledge resources such as Medline can address most clinicians' patient care information needs. Yet, significant barriers, notably lack of time, limit the use of these sources at the point of care. The most common information needs raised by clinicians are treatment-related. Comparative effectiveness studies allow clinicians to consider multiple treatment alternatives for a particular problem. Still, solutions are needed to enable efficient and effective consumption of comparative effectiveness research at the point of care. Objective: Design and assess an algorithm for automatically identifying comparative effectiveness studies and extracting the interventions investigated in these studies. Methods: The algorithm combines semantic natural language processing, Medline citation metadata, and machine learning techniques. We assessed the algorithm in a case study of treatment alternatives for depression. Results: Both precision and recall for identifying comparative studies was 0.83. A total of 86% of the interventions extracted perfectly or partially matched the gold standard. Conclusion: Overall, the algorithm achieved reasonable performance. The method provides building blocks for the automatic summarization of comparative effectiveness research to inform point of care decision-making. PMID:23920677

Zhang, Mingyuan; Del Fiol, Guilherme; Grout, Randall W; Jonnalagadda, Siddhartha; Medlin, Richard; Mishra, Rashmi; Weir, Charlene; Liu, Hongfang; Mostafa, Javed; Fiszman, Marcelo

2013-01-01

249

Gregory Cochran interview, \\  

Microsoft Academic Search

First, the conventional wisdom. Because Homo sapiens are a young species and haven't had time to genetically differentiate, we modern humans are all basically genetically identical. Because Homo sapiens figured out ways to use culture to overcome natural selection, human genetic evolution ceased ages ago. Because Homo sapiens are genetically very similar and not subject to natural selection, the differences

Marshall Poe; Gregory Cochran

2009-01-01

250

Long and short time variability of the global and the hemisphere temperature anomalies -Application of the Cochrane-Orcutt method  

NASA Astrophysics Data System (ADS)

Climate change holds a key position in science and policy today. A central issue to discuss in the scientific publications is the question how much humans contribute to the climate warming. To get answers in the last decades a lot of efforts were made to model the processes determining the climate, to make forecasts under defined conditions for the development of the society (climate projections). Another scientific tendency to find a more probable right answer consists in the application and development of the statistics to study responses of different climate forcings. Here a classical statistical method -the linear regression -is applied to examine the parts of the global and hemisphere warming due to different radiation forcings, by the use of their long and short time variabilities. The residuals of the regressions are significantly auto-correlated. Therefore the Cochrane-Orcutt method is applied to test the statistical significances. By multiple regression it is found that the main part of the temperature variability is caused by CO2. The impact of the total solar irradiance during the examined time period of 1866 up to 2000 is at the critical level of significance.

Werner, Rolf; Valev, Dimitare; Danov, Dimitar; Goranova, M.

251

A method of assessing the sensitivity of the Cochran-Mantel-Haenszel test to an unobserved confounder  

PubMed Central

Observational studies, including the case-control design frequently used in epidemiology, are subject to a number of biases and possible confounding factors. Failure to adjust with them may lead to an erroneous conclusion about the existence of a causal relationship between exposure and disease. The Cochran–Mantel–Haenszel (CMH) test is widely used to measure the strength of the association between an exposure and disease or response, after stratifying on the observed covariates. Thus, observed confounders are accounted for in the analysis. In practice, there may be causal variables that are unknown or difficult to obtain. Hence, they are not incorporated into the analysis. Sensitivity analysis enables investigators to assess the robustness of the findings. A method for assessing the sensitivity of the CMH test to an omitted confounder is presented here. The technique is illustrated by re-examining two datasets: one concerns the effect of maternal hypertension as a risk factor for low birth weight infants and the other focuses on the risk of allopurinol on having a rash. The computer code performing the sensitivity analysis is provided in appendix A.

Yu, Binbing; Gastwirth, Joseph L.

2008-01-01

252

Ginkgo biloba Compared with Cholinesterase Inhibitors in the Treatment of Dementia: A Review Based on Meta-Analyses by the Cochrane Collaboration  

Microsoft Academic Search

Data were derived from the Cochrane Collaboration meta-analyses of the efficacies of ginkgo, donepezil, rivastigmine and galantamine on changes in cognitive function in patients with dementia and, where necessary, were transformed to standardized mean differences. The proportion of patients discontinuing trials was used as a proxy measure of tolerability. Outcomes were assessed after 6 months of treatment. Trial data for

A. Kurz; B. Van Baelen

2004-01-01

253

Information Literacy for Users at the National Medical Library of Cuba: Cochrane Library Course for the Search of Best Evidence for Clinical Decisions  

ERIC Educational Resources Information Center

|The National Medical Library of Cuba is currently developing an information literacy program to train users in the use of biomedical databases. This paper describes the experience with the course "Cochrane Library: Evidence-Based Medicine," which aims to teach users how to make the best use of this database, as well as the evidence-based medicine…

Santana Arroyo, Sonia; del Carmen Gonzalez Rivero, Maria

2012-01-01

254

The UC MELVYL MEDLINE System: A Pilot Project for Access to Journal Literature through an Online Catalog.  

ERIC Educational Resources Information Center

|Describes a pilot project by the University of California to provide access to biomedical and health sciences literature through the integration of the MEDLINE database into the University's MELVYL online union catalog. The discussion covers the design, implementation and evaluation of the system, current planning efforts, and key technical and…

Lynch, Clifford A.; Berger, Michael G.

1989-01-01

255

The production of articles on cardiology from Latin America in Medline indexed journals.  

PubMed

Introduction: Latin America has dramatically increased the number of articles Publisher from 1995 to 2002, but the individual contribution of each country appears to be very unequal. Objectives: To analyze the production of articles on Cardiology research published in Latin American countries in the past years in international journals. Methods: A bibliography search was carried out throughout PubMed in regards to biomedical articles in general and on Cardiology in particular, corresponding to the period 1987 - 2006. Results: A total of 106 871 biomedical articles was identified, and 11 416 on Cardiology published between 1997 and 2006 by Latin American countries. This corresponds to 10.6% of articles on cardiovascular disease over the total. Brazil, Mexico and Argentina contributed with 80% of the publications in Latin America in the same period. The magnitude of growth since 1987 was between 5.9- and 15-fold for these countries. In regards to Brazil, since 1998 a significant increased number of publications was noted compared to Mexico and Argentina (P = 0.0001). The impact factor of the journals where each country published during 2006 showed that it was in average higher in the publications from Chile and Argentina compared to Brazil and Mexico (P <0.001). Conclusions: The scientific production in Cardiology from Latin America shows dramatic differences among the countries, and Brazil, Mexico, and Argentina alone provide 80% of the publications. Brazil seems to have led the region for 20 years, especially since 1998. From the quality of the articles point of view, considering the impact factor, Chile and Argentina appear to be better positioned. PMID:22188892

Borracci, Raúl A; Di Stéfano, María M; Voos Budal Arins, Marcel G; Calderón, José G E; Manente, Diego; Giorgi, Mariano A; Piñeiro, Daniel J; Dones, Wistremundo

2011-10-01

256

Presenting Evidence to Patients Online: What Do Web Users Think of Consumer Summaries of Cochrane Musculoskeletal Reviews?  

PubMed Central

Background The Internet has the potential to be an effective medium for delivering health care knowledge to consumers. While computer usability research makes recommendations about how to present Web-based information generally, there remains no clear guidance on how to present specific forms of health care research evidence online in a way that facilitates understanding and good health care decision making. Objective The two goals of this study were to describe the Cochrane Musculoskeletal Group’s (CMSG’s) process for developing online patient-focused summaries of systematic reviews and to evaluate the impressions of these summaries formed by users. Methods A process for summarizing the results of systematic reviews via consumer summaries has evolved over 15 years. An evaluation of this approach took the form of Internet surveys on the Arthritis Society of Canada website and surveys of members of the Canadian Arthritis Patient Alliance (CAPA). Respondents provided information on background, relationship to the decision, their satisfaction with and preparation for decision making, and suggestions for improvements to the summaries. Survey data were collected between August 1, 2005, and February 28, 2006. Results A total of 261 respondents completed the survey. The majority (226/261 or 87%) of respondents reported having an arthritis-related condition. The consumer summary approach was generally reviewed favorably by respondents, with most agreeing that the summary provided appropriate information (177/261 or 68%), would be useful to others (160/261 or 61%), was well laid out (159/261 or 61%), was easy to learn from (157/261 or 60%), and was useful to the reader (153/261 or 59%). Areas of potential improvement were indicated by relatively fewer respondents agreeing that they could easily find all the information they wanted (118/261 or 45%), by a substantial proportion being unable to judge whether the providers of the information are reliable (80/261 or 31%), and by a similar proportion being unable to determine whether the information presented was the best available (68/261 or 26%). Conclusions The CMSG has developed an approach to summarizing the results of often-technical systematic reviews into public-friendly consumer summaries. Our online survey showed that this approach was generally well liked but identified specific areas for improvement. Feedback from this survey will help to reshape and improve the current template for consumer summaries used by the CMSG.

Santesso, Nancy; O'Connor, Annette M; Lott, Alison; Lindgaard, Gitte; Syrowatka, Ania; Graham, Ian D; Tugwell, Peter S

2011-01-01

257

Constraint-induced movement therapy in the treatment of the upper limb in children with hemiplegic cerebral palsy: a Cochrane systematic review  

Microsoft Academic Search

Background: Constraint-induced movement therapy (CIMT) is emerging as a treatment approach for children with hemiplegic cerebral palsy. It aims to increase spontaneous use of the affected upper limb and limit the effects of learned non-use. This review evaluates the effectiveness of CIMT, modified CIMT or Forced use in the treatment of children with hemiplegic cerebral palsy.Design and methods: Systematic Cochrane

Brian Hoare; Christine Imms; Leeanne Carey; Jason Wasiak

2007-01-01

258

Mechanization of library procedures in the medium-sized medical library: XV. A study of the interaction of nonlibrarian searchers with the MEDLINE retrieval system.  

PubMed Central

The MEDLINE searchhes of sixteen nonlibrarian searchers at the School of Medicine Library, Washington University, were examined to determine the amount of utilization of the interactive capabilities of the system. The searchers made an average of 5.7 search statement modifications of their original searc statements and it was concluded that they did indeed use the interactive capabilities of MEDLINE.

Olson, P E

1975-01-01

259

Locating sex-specific evidence on clinical questions in MEDLINE: a search filter for use on OvidSP™  

Microsoft Academic Search

BACKGROUND: Many recently published clinical studies report sex-specific data. This information may help to improve clinical decision-making for both sexes, but it is not easily accessible in MEDLINE. The aim of this project was to develop and validate a search filter that would facilitate the retrieval of studies reporting high quality sex-specific data on clinical questions. METHODS: A filter was

Clara J Moerman; Rikie Deurenberg; Joke A Haafkens

2009-01-01

260

Implementation and Use of a University-Based Wide Area Computer Network for Access to the MEDLINE Database  

PubMed Central

Use of a wide-area network to provide access to a bibliographic database (MEDLINE) provides a functional means of assuring access to information important in the medical care setting. Access of this type promotes the use of information by making it available at the point of use and at the time of need. Availability of such a service promotes the use of computing technology and demonstrates its utility to otherwise resistant users.

Barclay, Mel L.; Shipman, Barbara L.; Grefsheim, Suzanne F.

1990-01-01

261

An open source infrastructure for managing knowledge and finding potential collaborators in a domain-specific subset of PubMed, with an example from human genome epidemiology  

PubMed Central

Background Identifying relevant research in an ever-growing body of published literature is becoming increasingly difficult. Establishing domain-specific knowledge bases may be a more effective and efficient way to manage and query information within specific biomedical fields. Adopting controlled vocabulary is a critical step toward data integration and interoperability in any information system. We present an open source infrastructure that provides a powerful capacity for managing and mining data within a domain-specific knowledge base. As a practical application of our infrastructure, we presented two applications – Literature Finder and Investigator Browser – as well as a tool set for automating the data curating process for the human genome published literature database. The design of this infrastructure makes the system potentially extensible to other data sources. Results Information retrieval and usability tests demonstrated that the system had high rates of recall and precision, 90% and 93% respectively. The system was easy to learn, easy to use, reasonably speedy and effective. Conclusion The open source system infrastructure presented in this paper provides a novel approach to managing and querying information and knowledge from domain-specific PubMed data. Using the controlled vocabulary UMLS enhanced data integration and interoperability and the extensibility of the system. In addition, by using MVC-based design and Java as a platform-independent programming language, this system provides a potential infrastructure for any domain-specific knowledge base in the biomedical field.

Yu, Wei; Yesupriya, Ajay; Wulf, Anja; Qu, Junfeng; Khoury, Muin J; Gwinn, Marta

2007-01-01

262

Public Library Participation in a MedlinePlus Go Local Project: Perceptions of Georgia Librarians and Staff.  

PubMed

In an effort to promote public library involvement in Georgia Health - Go Local, a National Library of Medicine initiative to link consumers to health resources in their local areas, staff at a large public library system in south Georgia were trained to enter local records into the Go Local database. Results of two follow-up focus groups indicated that participants were enthusiastic about demonstrating Go Local and MedlinePlus to library users but were not comfortable creating or maintaining Go Local records due to concerns about the relevance of the project, unease with medical terminology, varied levels of computer expertise, and worries about possible liability. PMID:21197119

Smith, Rita B

2010-01-01

263

Public Library Participation in a MedlinePlus® Go Local Project: Perceptions of Georgia Librarians and Staff  

PubMed Central

In an effort to promote public library involvement in Georgia Health – Go Local, a National Library of Medicine initiative to link consumers to health resources in their local areas, staff at a large public library system in south Georgia were trained to enter local records into the Go Local database. Results of two follow-up focus groups indicated that participants were enthusiastic about demonstrating Go Local and MedlinePlus to library users but were not comfortable creating or maintaining Go Local records due to concerns about the relevance of the project, unease with medical terminology, varied levels of computer expertise, and worries about possible liability.

Smith, Rita B.

2010-01-01

264

The value of focused assessment with sonography in trauma examination for the need for operative intervention in blunt torso trauma: a rebuttal to “emergency ultrasound-based algorithms for diagnosing blunt abdominal trauma (review)”, from the Cochrane Collaboration  

Microsoft Academic Search

Background and significance  The Cochrane Database of Systematic Reviews published a manuscript critical of the use of the FAST examination. The reference\\u000a is Stengel D. Bauwens K. Sehouli J. Rademacher G. Mutze S. Ekkernkamp A. Porzsolt F. Emergency ultrasound-based algorithms\\u000a for diagnosing blunt abdominal trauma. Cochrane Database of Systematic Reviews. (2):CD004446, 2005. UI: 15846717. The stated objective was the assessment of

Lawrence A. Melniker

2009-01-01

265

Cochrane Reviews of non-medication-based psychotherapeutic and other interventions for schizophrenia, psychosis, and bipolar disorder: A systematic literature review.  

PubMed

Mental health-care professionals are striving to keep up to date with health interventions that are effective and beneficial to patients. The Cochrane Reviews make available a systematic and up-to-date review of a comprehensive range of health interventions. We identified a total of 28 interventions from a systematic search and review of the Cochrane Reviews for either schizophrenia, psychosis, schizoaffective, or bipolar disorder. These interventions have been graded into tables of: strong support that merits application, moderate support that warrants consideration of application, not supported, and data that is deemed inconclusive. The tables provide a comprehensive summary and classification of evidence-based practices. This information is presented in a way to enable nurses and other health-care professionals to analyze their own practices to improve mental health services and outcomes for patients. Of the 28 interventions identified in this review, four had strong support and five had moderate support meriting application. Limitations of this review are discussed. PMID:19594644

Jung, Xenia Tricia; Newton, Richard

2009-08-01

266

Influence of a vertical subject on research in biomedicine and activities of The Cochrane Collaboration branch on medical students' knowledge and attitudes toward evidence-based medicine  

PubMed Central

Aim To investigate whether the introduction of a vertical subject on research in biomedicine and founding of The Cochrane Collaboration branch at the University of Split School of Medicine influenced students’ knowledge and attitudes toward evidence-based medicine (EBM), including the use of research literature. Methods We used a 26-item questionnaire on EBM knowledge and attitudes to survey 1232 medical students of all study years in 3 medical schools in Croatia (Split, Rijeka, Osijek) and the Croatian-speaking medical school in Mostar (Bosnia and Herzegovina). Results Students from the University of Split School of Medicine who had been exposed to the vertical subject on research in biomedicine and activities of The Cochrane Collaboration at the school had better knowledge and more positive attitudes toward EBM. In general, students rarely searched for evidence; 28% of students searched for evidence more than once a month and 96% of students used only textbooks in Croatian and teachers’ handouts, even though 74% of students agreed that articles from scholarly journals were an important supplement for textbooks. Conclusion Building up an environment that fosters EBM may be beneficial for students’ knowledge and attitudes toward EBM. Teachers should encourage and require using evidence during all the courses in medical school.

Balajic, Karolina; Barac-Latas, Vesna; Drenjancevic, Ines; Ostojic, Marko; Fabijanic, Damir; Puljak, Livia

2012-01-01

267

Smoking cessation programs targeted to women: A systematic review  

Microsoft Academic Search

Objectives: This systematic review aimed to examine tobacco interventions developed to meet the needs of women, to identify sex- and gender-specific components, and to evaluate their effects on smoking cessation in women. Methods: We searched electronic databases in the Cochrane Central Register of Controlled Trials, MEDLINE, PubMed, EBSCO, PsychINFO, CINHAL, and EMBASE; the search was not restricted by publication date.

Iris Torchalla; Chizimuzo T. C. Okoli; Joan L. Bottorff; Annie Qu; Nancy Poole; Lorraine Greaves

2012-01-01

268

Metabolic Effects of Fluoxetine in Adults with Type 2 Diabetes Mellitus: A Meta-Analysis of Randomized Placebo-Controlled Trials  

Microsoft Academic Search

BackgroundThe prevalence of obesity and diabetes is increasing dramatically throughout the world. Studies have shown that excess adiposity is a critical predictor of new onset T2DM. This meta-analysis is aimed to assess the metabolic effects of fluoxetine in T2DM.Methods and FindingsElectronic search was conducted in the database Medline, PubMed, EMBASE, and the Cochrane library, from inception through to March 2011.

Zi Ye; Lili Chen; Zhen Yang; Qin Li; Ying Huang; Min He; Shuo Zhang; Zhaoyun Zhang; Xuanchun Wang; Weiwei Zhao; Ji Hu; Chao Liu; Shen Qu; Renming Hu

2011-01-01

269

Nutritional access routes following oesophagectomy—a systematic review  

Microsoft Academic Search

Nutritional support in patients undergoing oesophagectomy is of paramount importance in this usually malnourished patient group, but encountering significant clinical practice variation between units. Our aim was therefore to assess the strength of evidence behind nutritional support routes post-oesophagectomy. The Cochrane Library and Controlled Trials Registry, MEDLINE (Ovid) (1966–April 2009), PubMed, EMBASE (1966–April 2009), CINAHL, Web of knowledge and SCOPUS

G A Markides; B Al-Khaffaf; J Vickers

2011-01-01

270

Head-to-head comparison of H2-receptor antagonists and proton pump inhibitors in the treatment of erosive esophagitis: A  

Microsoft Academic Search

Abstract Abstract Abstract Abstract AIM: To systematically evaluate the efficacy of H2-receptor antagonists (H2RAs) and proton pump inhibitors in healing erosive esophagitis (EE). METHODS: A meta-analysis was performed. A literature search was conducted in PubMed, Medline, Embase, and Cochrane databases to include randomized controlled head-to-head comparative trials evaluating the efficacy of H2RAs or proton pump inhibitors in healing EE. Relative

Wei-Hong Wang; Jia-Qing Huang; Ge-Fan Zheng; Harry Hua-Xiang Xia; Wai-Man Wong; Shiu-Kum Lam; Benjamin Chun-Yu Wong

271

Which is the most effective drug or method of sedation used for anxious children?  

Microsoft Academic Search

Data sourcesMedline, PubMed, Embase, Cochrane Central Register of Controlled Trials, Dissertation Abstracts, SIGLE, the World Wide Web (Google) and the Community of Science Database were searched for relevant trials and references. Reference lists from relevant articles were scanned and the authors contacted to identify trials and obtain additional information. There were no language restrictions. Trials pre-1966 were not searched.Study selectionStudies

Nigel D Robb

2005-01-01

272

Evidence-based treatment of open ankle fractures  

Microsoft Academic Search

Fractures of the ankle are fairly common injuries. Open ankle fractures are much less common and associated with severe injuries\\u000a to surrounding tissues. We have performed a systematic review of the literature concerning the clinical results and complication\\u000a rates in the treatment of open ankle fractures. We conducted a search limited to the following databases: Pubmed\\/Medline,\\u000a Cochrane Database of Systematic

Caroline C. C. Hulsker; Sanne Kleinveld; Chris B. L. Zonnenberg; Mike Hogervorst; Michel P. J. van den Bekerom

273

Long acting ?2 agonists for stable chronic obstructive pulmonary disease with poor reversibility: a systematic review of randomised controlled trials  

Microsoft Academic Search

BACKGROUND: The long acting ?2-agonists, salmeterol and formoterol, have been recommended, by some, as first line treatment of stable chronic obstructive pulmonary disease (COPD). We reviewed evidence of efficacy and safety when compared with placebo or anticholinergic agents in patients with poorly reversible COPD. METHODS: After searching MEDLINE, EMBASE, HealthSTAR, BIOSIS Previews, PASCAL, ToxFile, SciSearch, the Cochrane Library, and PubMed,

Don Husereau; Vijay Shukla; Michel Boucher; Shaila Mensinkai; Robert Dales

2004-01-01

274

Falls-prevention programs for older ambulatory community dwellers: from public health research to health promotion policy  

Microsoft Academic Search

Summary Objectives:Falls result in significant morbidity and mortality among the elderly. The purpose was to review the public health research literature on falls prevention among community-dwelling older adults and derive evidence-based implications for health promotion policy. Methods:CINAHL, COCHRANE, EMBASE, MEDLINE, and PUBMED databases were used to search the research literature concerning falls epidemiology, injury mechanisms, and falls-prevention strategies published during

Ray Marks; John P. Allegrante

2004-01-01

275

Laparoscopic-assisted vaginal hysterectomy vs abdominal hysterectomy for benign disease: a meta-analysis of randomized controlled trials  

Microsoft Academic Search

The objective of this meta-analysis was to assess whether laparoscopic-assisted vaginal hysterectomy achieves better clinical results compared with abdominal hysterectomy. Medline (PubMed), EMBASE, Web of Science, ProQuest, Cochrane Library and China Biological Medicine Database were searched to identify randomized controlled trials that compared laparoscopic-assisted vaginal hysterectomy with abdominal hysterectomy. Twenty-three trials were studied and the analysis was performed using Review

Yue-xiong Yi; Wei Zhang; Qi Zhou; Wan-ru Guo; Yu Su

276

The effectiveness of hydrotherapy in the management of fibromyalgia syndrome: a systematic review  

Microsoft Academic Search

Hydrotherapy is often used in the treatment of fibromyalgia syndrome (FMS), however there has been limited evaluation of its\\u000a effectiveness. The aim of this systematic review was therefore to examine the effectiveness of hydrotherapy in the management\\u000a of FMS. AMED, BNI, CINAHL, The Cochrane Library, EMBASE, MEDLINE, ProQuest, PubMed, Science Direct and Web of Science were\\u000a searched (1990–July 2006). Key

Joseph G. McVeigh; Helen McGaughey; Melissa Hall; Patricia Kane

2008-01-01

277

Effect of fish oil on arrhythmias and mortality: systematic review  

Microsoft Academic Search

Objective To synthesise the literature on the effects of fish oil—docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA)—on mortality and arrhythmias and to explore dose response and formulation effects.Design Systematic review and meta-analysis.Data sources Medline, Embase, the Cochrane Library, PubMed, CINAHL, IPA, Web of Science, Scopus, Pascal, Allied and Complementary Medicine, Academic OneFile, ProQuest Dissertations and Theses, Evidence-Based Complementary Medicine, and

Hernando León; Marcelo C Shibata; Soori Sivakumaran; Marlene Dorgan; Trish Chatterley; Ross T Tsuyuki

2008-01-01

278

Formocresol and ferric sulfate have similar success rates in primary molar pulpotomy  

Microsoft Academic Search

Data sourcesMedline Ovid Library, the Cochrane Library, PubMed, Embase, Science Citation Index (SCI) and System for Information on Grey Literature in Europe (SIGLE).Study selectionReviews, full reports, or research abstracts of prospective, retrospective, comparative, and\\/or radiographic studies were included, while case reports and letters were excluded.Data extraction and synthesisA total of 13 studies (three randomized clinical trials and 10 clinical trials)

Chris Deery

2005-01-01

279

Adrenergic-?2 receptor polymorphism and athletic performance  

Microsoft Academic Search

The focus of this review is to evaluate the influence of ?2-adrenergic receptor (ADRB2) polymorphism on human physiological function and in turn on athletic performance. A narrative review is conducted on available literature using MedLine, Pubmed and the Cochrane Library to document the location and function of ADRB2 receptors, and specifically to address the influence of genetic polymorphisms on cardiovascular,

Vishnu Sarpeshkar; David J Bentley

2010-01-01

280

Meta-analysis: the efficacy of nootropic agent Cerebrolysin in the treatment of Alzheimer’s disease  

Microsoft Academic Search

Summary.  To determine the therapeutic effect of nootropic agent Cerebrolysin on patients with mild to moderate Alzheimer’s disease\\u000a (AD), we searched the Cochrane Library, Medline, PubMed, and Chinese Biomedical Literature Analysis and Retrieval System for\\u000a Compact Disc (CBMDISC), and communicated with EBEWE Pharmaceutical Ltd, for randomized trials comparing Cerebrolysin with\\u000a placebo in AD. Available data on clinical global impression, cognitive performance

Z.-H. Wei; Q.-B. He; H. Wang; B.-H. Su; H.-Z. Chen

2007-01-01

281

Best Practice Updates for Pediatric\\/Adolescent Weight Loss Surgery  

Microsoft Academic Search

The objective of this study is to update evidence-based best practice guidelines for pediatric\\/adolescent weight loss surgery (WLS). We performed a systematic search of English-language literature on WLS and pediatric, adolescent, gastric bypass, laparoscopic gastric banding, and extreme obesity published between April 2004 and May 2007 in PubMed, MEDLINE, and the Cochrane Library. Keywords were used to narrow the search

Janey S. A. Pratt; Carine M. Lenders; Emily A. Dionne; Alison G. Hoppin; George L. K. Hsu; Thomas H. Inge; David F. Lawlor; Margaret F. Marino; Alan F. Meyers; Jennifer L. Rosenblum; Vivian M. Sanchez

2009-01-01

282

Impact of Thrombophilia on Risk of Arterial Ischemic Stroke or Cerebral Sinovenous Thrombosis in Neonates and Children A Systematic Review and Meta-Analysis of Observational Studies  

Microsoft Academic Search

Background-The aim of this study was to estimate the impact of thrombophilia on risk of first childhood stroke through a meta-analysis of published observational studies. Methods and Results-A systematic search of electronic databases (Medline via PubMed, EMBASE, OVID, Web of Science, The Cochrane Library) for studies published from 1970 to 2009 was conducted. Data on year of publication, study design,

G. Kenet; L. K. Luetkhoff; M. Albisetti; T. Bernard; M. Bonduel; L. Brandao; S. Chabrier; A. Chan; G. deVeber; B. Fiedler; H. J. Fullerton; N. A. Goldenberg; E. Grabowski; G. Guenther; C. Heller; S. Holzhauer; Iorio Di A; J. Journeycake; R. Junker; F. J. Kirkham; K. Kurnik; J. K. Lynch; C. Male; M. Manco-Johnson; R. Mesters; P. Monagle; Ommen van C. H; L. Raffini; K. Rostasy; P. Simioni; R. D. Straeter; G. Young; U. Nowak-Goettl

2010-01-01

283

Needling therapies in the management of myofascial trigger point pain: A systematic review  

Microsoft Academic Search

Cummings TM, White AR. Needling therapies in the management of myofascial trigger point pain: a systematic review. Arch Phys Med Rehabil 2001;82:986-92. Objective: To establish whether there is evidence for or against the efficacy of needling as a treatment approach for myofascial trigger point pain. Data Sources: PubMed, Ovid MEDLINE, Ovid EMBASE, the Cochrane Library, AMED, and CISCOM databases, searched

T. Michael Cummings; Adrian R. White

2001-01-01

284

A review of the treatment of chronic hepatitis C virus infection in cirrhosis  

Microsoft Academic Search

Background: Cirrhosis developing during chronic infection with the hepatitis C virus (HCV) poses a risk of anticipated liver-related death, therefore representing a dominant indication to anti-HCV therapy.Objective: This review highlights the efficacy and safety of treatment of HCV infection in cirrhotic patients with respect to the clinical stage of the disease.Methods: The PubMed, MEDLINE, EMBASE, and Cochrane databases, as well

Elena Vezali; Alessio Aghemo; Massimo Colombo

2010-01-01

285

A MEDLINE categorization algorithm  

Microsoft Academic Search

BACKGROUND: Categorization is designed to enhance resource description by organizing content description so as to enable the reader to grasp quickly and easily what are the main topics discussed in it. The objective of this work is to propose a categorization algorithm to classify a set of scientific articles indexed with the MeSH thesaurus, and in particular those of the

Stefan J Darmoni; Aurelie Névéol; Jean-Marie Renard; Jean-Francois Gehanno; Lina F Soualmia; Badisse Dahamna; Benoit Thirion

2006-01-01

286

About MedlinePlus  

MedlinePLUS

... Director Dr. Donald A.B. Lindberg, Director, National Library of Medicine View Dr. Lindberg's welcome (Quicktime video ... good health information from the world's largest medical library, the National Library of Medicine. Health professionals and ...

287

CD Plus' OVID MEDLINE  

Microsoft Academic Search

CD Plus' OVID software is discussed in relation to CD Plus' previous software, CDP 2.0. Two versions of OVID are reviewed-3.0 (Release 8) and 2.1 (Release 3), tested as a beta product at the Ruth Lilly Medical Library (RLML) in Indianapolis. OVID 2.1, a hybrid between CDP and OVID 3.0, was designed to facilitate the transition between CDP and OVID.

Frances A. Brahmi; Kellie Kaneshiro

1994-01-01

288

From Shakespeare to Star Trek and beyond: a Medline search for literary and other allusions in biomedical titles  

PubMed Central

Objectives To document biomedical paper titles containing literary and other allusions. Design Retrospective survey. Setting Medline (1951 to mid-2005) through Dialog Datastar. Main outcome measure Allusions to Shakespeare, Hans Christian Andersen, proverbs, the Bible, Lewis Carroll, and movie titles, corrected and scaled for five year periods 1950-4 to 2000-4. Results More than 1400 Shakespearean allusions exist, a third of them to “What's in a name” and another third to Hamlet—mostly to “To be or not to be.” The trend of increasing use of allusive titles, identified from Shakespeare and Andersen, is paralleled by allusions to Carroll and proverbs; the trend of biblical allusions is also upward but is more erratic. Trends for newer allusions are also upwards, including the previously surveyed “paradigm shift.” Allusive titles are likely to be to editorial or comment rather than to original research. Conclusions The similar trends are presumably a mark of a particular learnt author behaviour. Newer allusions may be becoming more popular than older ones. Allusive titles can be unhelpful to reviewers and researchers, and many are now clichés. Whether they attract readers or citations is unknown, but better ways of gaining attention exist.

Goodman, Neville W

2005-01-01

289

Integrating CD-ROM Medline with electronic mail: first step in implementing new strategy for online reference library.  

PubMed

Simultaneous ACCESS to and DISSEMINATION of electronically available PROFESSIONAL KNOWLEDGE, in a productive, Cost-of-Ownership effective, and affordable manner are now achievable. Emerging MANAGEMENT-OF-INFORMATION and SYSTEMS-INTEGRATION disciplines are essential contributing factors to devising and implementing NEW STRATEGIES for ONLINE REFERENCE LIBRARIES. Bringing integrated information closer to the ultimate user and RESHAPING the electronic databases and full-text management systems MARKETPLACE are the most significant outcomes. Key technology attributes are advancements in CD-ROM, Networking, and office automation. We have proven this concept by developing an INTERFACE between MEDLINE from COMPACT CAMBRIDGE and ALL-IN-1 from DIGITAL EQUIPMENT CORPORATION. Saved search results are automatically routed to the individual's ALL-IN-1 account where further DOCUMENT MANAGEMENT and electronic mail functions may be performed. A 486Ware system from Logicraft and a five-members VAX-Cluster (respectively), are linked in a DECNet environment that is the foundation of Children's Integrated Hospital Information System. In phase one of the project up to 8 SIMULTANEOUS USERS may access the 8 RECENT YEARS, from any one of 1500 ACCESS POINTS (local and remote), and utilize any one of 150 NETWORKED PRINTERS. Opportunities are now within reach to expand the electronic library services while utilizing progressive methods and taking advantage of the best available technologies. PMID:1807668

Ribitzky, R

1991-01-01

290

Anesthetic dose neuraxial blockade increases the success rate of external fetal version: a meta-analysis  

Microsoft Academic Search

Purpose  This study is a meta-analysis evaluating the efficacy of central neuraxial blockade (CNB) (epidural or spinal) to facilitate\\u000a fetal version.\\u000a \\u000a \\u000a \\u000a \\u000a Methods  A search with no language restriction for all available randomized controlled trials (RCT) was conducted in PUBMED on July\\u000a 2, 2009, EMBASE 1980 to 2009 Week 27, Ovid MEDLINE(R) 1950 to Week 4 in June 2009, EBM Reviews - Cochrane

Anne Lavoie; Joanne Guay

2010-01-01

291

Does use of the CONSORT Statement impact the completeness of reporting of randomised controlled trials published in medical journals? A Cochrane reviewa  

PubMed Central

Background The Consolidated Standards of Reporting Trials (CONSORT) Statement is intended to facilitate better reporting of randomised clinical trials (RCTs). A systematic review recently published in the Cochrane Library assesses whether journal endorsement of CONSORT impacts the completeness of reporting of RCTs; those findings are summarised here. Methods Evaluations assessing the completeness of reporting of RCTs based on any of 27 outcomes formulated based on the 1996 or 2001 CONSORT checklists were included; two primary comparisons were evaluated. The 27 outcomes were: the 22 items of the 2001 CONSORT checklist, four sub-items describing blinding and a ‘total summary score’ of aggregate items, as reported. Relative risks (RR) and 99% confidence intervals were calculated to determine effect estimates for each outcome across evaluations. Results Fifty-three reports describing 50 evaluations of 16,604 RCTs were assessed for adherence to at least one of 27 outcomes. Sixty-nine of 81 meta-analyses show relative benefit from CONSORT endorsement on completeness of reporting. Between endorsing and non-endorsing journals, 25 outcomes are improved with CONSORT endorsement, five of these significantly (? = 0.01). The number of evaluations per meta-analysis was often low with substantial heterogeneity; validity was assessed as low or unclear for many evaluations. Conclusions The results of this review suggest that journal endorsement of CONSORT may benefit the completeness of reporting of RCTs they publish. No evidence suggests that endorsement hinders the completeness of RCT reporting. However, despite relative improvements when CONSORT is endorsed by journals, the completeness of reporting of trials remains sub-optimal. Journals are not sending a clear message about endorsement to authors submitting manuscripts for publication. As such, fidelity of endorsement as an ‘intervention’ has been weak to date. Journals need to take further action regarding their endorsement and implementation of CONSORT to facilitate accurate, transparent and complete reporting of trials.

2012-01-01

292

Regular inhaled short acting ss2 agonists for the management of stable chronic obstructive pulmonary disease: Cochrane systematic review and meta-analysis  

PubMed Central

Background: Despite the lack of reversibility, patients with chronic obstructive pulmonary disease (COPD) often report symptomatic improvement with inhaled short acting ß2 agonist bronchodilators (ISABAs) in the management of both stable and acute exacerbations of COPD. A review of the literature was undertaken to determine the effectiveness of regular treatment with ISABAs compared with placebo in stable COPD. Methods: A search for randomised controlled trials was carried out using the Cochrane Collaboration database of trials up to and including May 2002. Results: Thirteen studies of 7 days to 8 weeks in duration on 237 patients aged 56–70 years with forced expiratory volume in 1 second (FEV1) 60–70% predicted were included in the review. All studies used a crossover design with adequate washout periods and were of high methodological quality. ISABA was delivered either through a nebuliser or a pressurised metered dose inhaler. Spirometric tests performed at the end of the study and after the treatment (post-bronchodilator) showed a slight but significant increase in FEV1 and forced vital capacity (FVC) compared with placebo. In addition, both morning and evening peak expiratory flow rate (PEFR) were significantly better during active treatment than during placebo. An improvement in the daily breathlessness score was observed with ISABA treatment. The risk of treatment failure was reduced by more than 50% with ISABA. Preference for ISABA was nine times higher than for placebo. Conclusions: Use of ISABA on a regular basis for at least 7 days in patients with stable COPD is associated with improvements in post-bronchodilator lung function and decreases in both breathlessness and treatment failure. This review has shown that regular administration of ISABAs is an effective and inexpensive treatment for the management of patients with stable COPD.

Ram, F; Sestini, P

2003-01-01

293

Low-molecular-weight heparins are superior to vitamin K antagonists for the long term treatment of venous thromboembolism in patients with cancer: a cochrane systematic review  

PubMed Central

Background Cancer and its therapies increase the risk of venous thromboembolism. Compared to patients without cancer, patients with cancer anticoagulated for venous thromboembolism are more likely to develop recurrent thrombotic events and major bleeding. Addressing all important outcomes including harm is of great importance to make evidence based health care decisions. The objective of this study was to compare low molecular weight heparin (LMWH) and oral anticoagulants (vitamin K antagonist (VKA) and ximelagatran) for the long term treatment of venous thromboembolism in patients with cancer. Methods A systematic review of the medical literature. We followed the Cochrane Collaboration methodology for conducting systematic reviews. We assessed methodological quality for each outcome by grading the quality of evidence using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology. Results Eight randomized controlled trials (RCTs) were eligible and reported data for patients with cancer. The quality of evidence was low for death and moderate for recurrent venous thromboembolism. LMWH, compared to VKA provided no statistically significant survival benefit (Hazard ratio (HR) = 0.96; 95% CI 0.81 to 1.14) but a statistically significant reduction in venous thromboembolism (HR = 0.47; 95% (Confidence Interval (CI) = 0.32 to 0.71). There was no statistically significant difference between LMWH and VKA in bleeding outcomes (RR = 0.91; 95% CI = 0.64 to 1.31) or thrombocytopenia (RR = 1.02; 95% CI = 0.60 to 1.74). Conclusion For the long term treatment of venous thromboembolism in patients with cancer, LMWH compared to VKA reduces venous thromboembolism but not death.

Akl, Elie A; Barba, Maddalena; Rohilla, Sandeep; Terrenato, Irene; Sperati, Francesca; Muti, Paola; Schunemann, Holger J

2008-01-01

294

Still too little qualitative research to shed light on results from reviews of effectiveness trials: A case study of a Cochrane review on the use of lay health workers  

Microsoft Academic Search

Background  Qualitative research is used increasingly alongside trials of complex interventions to explore processes, contextual factors,\\u000a or intervention characteristics that may have influenced trial outcomes. Qualitative research conducted alongside trials can\\u000a also be used to shed light on the results of systematic reviews of effectiveness by looking for factors that can help explain\\u000a heterogeneous results across trials. In a Cochrane review

Claire Glenton; Simon Lewin; Inger B Scheel

2011-01-01

295

Ideas for training teachers and search analysts using on-line services, arising from the training working group of the MEDLINE Workshop, 1979.  

PubMed

The types of organization offering training courses in on-line information retrieval techniques are grouped into four broad classes: system suppliers and data-base owners, library schools, independent organizations and individuals within organizations. The form of courses offered by the suppliers of the National Library of Medicine's (NLM) data-bases in Europe and Australia, discussed at the MEDLINE Workshop held in Paris in June 1979, are described. NLM already has a large programme of continuing education for search analysts, but not very much has been attempted in Europe as yet, because the services are still comparatively new. The training needed for teachers of on-line services was briefly discussed at the MEDLINE Workshop. This training includes a knowledge of computerized techniques, details of the actual system and software, public speaking, the design of courses and lectures, and the design of documentation and aids. After being trained initially, a teacher also has to keep up-to-date with changes made by the suppliers as well as developments in teaching. Seminars are proposed as a means of achieving this. PMID:6995734

Hills, S

296

New waves, new problems--use of CD-ROM MEDLINE in the Medical Library of the National University of Singapore.  

PubMed

In the rapid development of optical disc technology, compact disc read-only-memory (CD-ROM) is gaining popularity as a reference tool. The National University of Singapore Medical Library (NUSML) is the first special library of the University Library System to introduce CD-ROM technology by setting up of the MEDLINE on CD-ROM system to complement its reference and information services since February 1989. The experiences of the Library is setting up the system and feedback obtained from end users through a questionnaire survey are presented in this paper. The success of the implementation of the new services has also given rise to new problems which have implications on library user education programmes, manpower planning, collection development and system security. PMID:2260811

Wee, J G

1990-09-01

297

Selecting CD-ROM databases for nursing students: a comparison of MEDLINE and the Cumulative Index to Nursing and Allied Health Literature (CINAHL).  

PubMed Central

With the introduction of the Cumulative Index to Nursing and Allied Health Literature (CINAHL) on CD-ROM, research was initiated to compare coverage of nursing journals by CINAHL and MEDLINE in this format, expanding on previous comparison of these databases in print and online. The study assessed search results for eight topics in 1989 and 1990 citations in both databases, each produced by SilverPlatter. Results were tallied and analyzed for number of records retrieved, unique and overlapping records, relevance, and appropriateness. An overall precision score was developed. The goal of the research was to develop quantifiable tools to help determine which database to purchase for an academic library serving an undergraduate nursing program.

Okuma, E

1994-01-01

298

MedlinePlus: Drugs, Herbs and Supplements: MedlinePlus  

MedlinePLUS

... approved labels included in drug packages, see DailyMed . Herbs and Supplements Browse dietary supplements and herbal remedies ... their effectiveness, usual dosage, and drug interactions. All herbs and supplements Prescription and over-the-counter medication ...

299

Career choice in academic medicine  

Microsoft Academic Search

OBJECTIVES: To review systematically the evidence about what factors influence the decision to choose or not choose a career in academic\\u000a medicine.\\u000a \\u000a \\u000a DESIGN: A systematic review of relevant literature from 1990 to May 2005.\\u000a \\u000a \\u000a \\u000a \\u000a DATA SOURCES: Searches of The Cochrane Library, Medline (using Ovid and PubMed) from 1990 to May 2005, and EMBASE from 1990 to May 2005\\u000a were completed

Sharon E. Straus; Christine Straus; Katina Tzanetos

2006-01-01

300

Efficacy and safety of atomoxetine for attention-deficit\\/hyperactivity disorder in children and adolescents—meta-analysis and meta-regression analysis  

Microsoft Academic Search

Objectives  The objective of this study was to evaluate the efficacy and safety of atomoxetine in children and adolescents.\\u000a \\u000a \\u000a \\u000a Materials and methods  We searched for studies published between 1985 and 2006 through Medline, PubMed, PsychInfo and Cochrane Central Register of\\u000a Controlled Trials (CENTRAL 2006 Issue 3) using keywords related to atomoxetine and attention-deficit\\/hyperactivity disorder\\u000a (ADHD) and scanned though reference lists. We included

Jackie Y. W. Cheng; Ronald Y. L. Chen; John S. N. Ko; Emil M. L. Ng

2007-01-01

301

Are the pneumococcal polysaccharide vaccines effective? Meta-analysis of the prospective trials  

Microsoft Academic Search

The objective was to review the evidence of effectiveness of the polyvalent polysaccharide pneumococcal vaccine from prospective\\u000a properly randomised controlled trials comparing pneumococcal vaccines with placebo in subjects who are immunocompetent and\\u000a those likely to have an impaired immune system.\\u000a \\u000a \\u000a Databases searched included the Cochrane Library, (issue 2, 2000), MEDLINE (1966-August 2000), PubMed (to August 2000) and\\u000a EMBASE ( to

R Andrew Moore; Philip J Wiffen; Benjamin A Lipsky

2000-01-01

302

Effects on the fetus and newborn of maternal analgesia and anesthesia: a review  

Microsoft Academic Search

Purpose  To review the effects of maternal anesthesia and analgesia on the fetus and newborn.\\u000a \\u000a \\u000a \\u000a Methods  An on-line computerized search of Medline, Embase, and the Cochrane Collaboration via PubMed was conducted. English language\\u000a articles were selected. The bibliographies of relevant articles and additional material from other published sources were\\u000a retrieved and reviewed.\\u000a \\u000a \\u000a \\u000a Principal findings  No one test clearly separates the effects on the

Judith Littleford

2004-01-01

303

The role of the health services in the prevention of alcohol-related facial injury.  

PubMed

This paper outlines the preventive health strategic measures that are currently in place and it endeavours to consider how improvements can be made to our national preventive strategy with the goal of reducing alcohol-related facial injuries. It is based on a review of the literature sourced through PubMed, Ovid Medline and the Cochrane database. The main findings are that increased funding, legislative amendment and media involvement are key to improving the work of the health services in their struggle to limit the ever increasing alcohol-related incidents that are experienced by society today. PMID:19848065

McHugh, E E; Al-Awadhi, E; Stassen, L F A

2009-10-01

304

Treatment of Obesity in Primary Care Practice in the United States: A Systematic Review  

Microsoft Academic Search

OBJECTIVES  This review examines the results of randomized controlled trials in which behavioral weight loss interventions, used alone\\u000a or with pharmacotherapy, were provided in primary care settings.\\u000a \\u000a \\u000a \\u000a DATA SOURCES  Literature search of MEDLINE, PubMed, Cochrane Systematic Reviews, CINAHL, and EMBASE (1950-present). Inclusion criteria for\\u000a studies were: (1) randomized trial, (2) obesity intervention in US adults, and (3) conducted in primary care or

Adam Gilden Tsai; Thomas A. Wadden

2009-01-01

305

The Impact of Obesity on Outcome after Major Colorectal Surgery  

Microsoft Academic Search

Purpose  There is an epidemic of obesity in the Western world and its associated substantial morbidity and mortality. This review examines\\u000a the data on the impact of obesity on perioperative morbidity and mortality specifically in the context of colorectal surgery.\\u000a \\u000a \\u000a \\u000a Methods  MEDLINE, PUBMED, and the Cochrane library were searched for relevant articles. A manual search for other pertinent papers\\u000a also was performed.

Kelly A. Gendall; Sumit Raniga; Ross Kennedy; Frank A. Frizelle

2007-01-01

306

Contact Us: MedlinePlus  

MedlinePLUS

... Republic of (Congo-Kinshasa) Congo, Democratic Republic of Cook Islands Costa Rica Croatia Local Name:(Hrvatska) Cuba Cyprus ... Islands (Malvinas) Fiji Finland France French Guiana French Polynesia Gabon Gambia Georgia Germany Ghana Greece Greenland Guadeloupe ...

307

JICST-E (Japan Information Centre of Science and Technology—English File): its construction in providing access to online Japanese biomedical information with selected comparisons to EMBASE and MEDLINE  

Microsoft Academic Search

The database JICST-E (Japan Information Centre of Sci ence and and Technology, English language database in Sci ence, Technology and Medicine) is compared with EMBASE and MEDLINE for the coverage of Japanese biomedical litera ture. Six different searches were run in each of these databases using the terms (1) diclofenac, (2) lymphokine activated killer cells, (3) tumour necrosis factor, (4)

R. J. Sodha; B. J. Kostrewski; O. Schier

1990-01-01

308

Search terms and a validated brief search filter to retrieve publications on health-related values in Medline: a word frequency analysis study  

PubMed Central

Objective Healthcare debates and policy developments are increasingly concerned with a broad range of values-related areas. These include not only ethical, moral, religious, and other types of values ‘proper’, but also beliefs, preferences, experiences, choices, satisfaction, quality of life, etc. Research on such issues may be difficult to retrieve. This study used word frequency analysis to generate a broad pool of search terms and a brief filter to facilitate relevant searches in bibliographic databases. Methods Word frequency analysis for ‘values terms’ was performed on citations on diabetes, obesity, dementia, and schizophrenia (Medline; 2004–2006; 4440 citations; 1?110?291 words). Concordance® and SPSS 14.0 were used. Text words and MeSH terms of high frequency and precision were compiled into a search filter. It was validated on datasets of citations on dentistry and food hypersensitivity. Results 144 unique text words and 124 unique MeSH terms of moderate and high frequency (?20) and very high precision (?90%) were identified. Of these, 19 text words and seven MeSH terms were compiled into a ‘brief values filter’. In the derivation dataset, it had a sensitivity of 76.8% and precision of 86.8%. In the validation datasets, its sensitivity and precision were, respectively, 70.1% and 63.6% (food hypersensitivity) and 47.1% and 82.6% (dentistry). Conclusions This study provided a varied pool of search terms and a simple and highly effective tool for retrieving publications on health-related values. Further work is required to facilitate access to such research and enhance its chances of being translated into practice, policy, and service improvements.

Sutcliffe, Paul; Fulford, K W M (Bill); Dale, Jeremy

2011-01-01

309

Growing research - involving students in Cochrane reviews.  

PubMed

In 1992, the Journal of the American Medical Association published a paper launching a new paradigm for lifelong learning in medical practice - evidence based medicine (EBM). Twenty years later EBM is known well beyond the field of clinical practice and has become an integral part of medical curricula worldwide. PMID:22003485

van Driel, Mieke

2011-10-01

310

Lake Cochrane, Deuel County, South Dakota.  

National Technical Information Service (NTIS)

Annual total phosphorus and total nitrogen loadings to the lake were estimated and subdivided according to either point or non-point source origin. An assessment of the lake's trophic condition and limiting nutrient is also provided. All data collected by...

1977-01-01

311

Clinical practice: between Aristotle and Cochrane.  

PubMed

Health and disease consist of amino acids and self image, cell membranes and human ideals, muscles and politics. Only to a limited extent can clinical practice be based on science. It can never be carried on in isolation from political, and cultural forces that influence patients' health behaviour. Evidence-based medicine is essential but not sufficient. A continuous relationship with patients is a conditio sine qua non for general practice. The general practitioner must be a master of pragmatic medicine. Rationality, the dominant modern trend, may be dangerous for patients and doctors: (1) advances in technology can give patients and doctors the illusion of mastering the universe; (2) patients complain of being treated like biomachines, without human touch. Another symptom of modernity is the decline of religion. But patients and doctors are by no means rational beings. God, destiny and hope are replaced by modern medico-scientific megalomania. Modern medicine is also strongly influenced by commercialization and invasion by bureaucrats. Instead of becoming a biomedical robot, the general practitioner must learn to value the Aristotelian concept of phronesis. It means practical wisdom and can only be gained by personal experience; a form of learning by doing. Good clinical practice cannot come from science alone, or from personal experience alone. It is an amalgam of scientia and phronesis. PMID:9540138

Fugelli, P

1998-02-01

312

Searching for controlled trials of complementary and alternative medicine: a comparison of 15 databases.  

PubMed

This project aims to assess the utility of bibliographic databases beyond the three major ones (MEDLINE, EMBASE and Cochrane CENTRAL) for finding controlled trials of complementary and alternative medicine (CAM). Fifteen databases were searched to identify controlled clinical trials (CCTs) of CAM not also indexed in MEDLINE. Searches were conducted in May 2006 using the revised Cochrane highly sensitive search strategy (HSSS) and the PubMed CAM Subset. Yield of CAM trials per 100 records was determined, and databases were compared over a standardized period (2005). The Acudoc2 RCT, Acubriefs, Index to Chiropractic Literature (ICL) and Hom-Inform databases had the highest concentrations of non-MEDLINE records, with more than 100 non-MEDLINE records per 500. Other productive databases had ratios between 500 and 1500 records to 100 non-MEDLINE records-these were AMED, MANTIS, PsycINFO, CINAHL, Global Health and Alt HealthWatch. Five databases were found to be unproductive: AGRICOLA, CAIRSS, Datadiwan, Herb Research Foundation and IBIDS. Acudoc2 RCT yielded 100 CAM trials in the most recent 100 records screened. Acubriefs, AMED, Hom-Inform, MANTIS, PsycINFO and CINAHL had more than 25 CAM trials per 100 records screened. Global Health, ICL and Alt HealthWatch were below 25 in yield. There were 255 non-MEDLINE trials from eight databases in 2005, with only 10% indexed in more than one database. Yield varied greatly between databases; the most productive databases from both sampling methods were Acubriefs, Acudoc2 RCT, AMED and CINAHL. Low overlap between databases indicates comprehensive CAM literature searches will require multiple databases. PMID:19468052

Cogo, Elise; Sampson, Margaret; Ajiferuke, Isola; Manheimer, Eric; Campbell, Kaitryn; Daniel, Raymond; Moher, David

2011-06-23

313

Connecting the Dots between PubMed Abstracts  

Microsoft Academic Search

BackgroundThere are now a multitude of articles published in a diversity of journals providing information about genes, proteins, pathways, and diseases. Each article investigates subsets of a biological process, but to gain insight into the functioning of a system as a whole, we must integrate information from multiple publications. Particularly, unraveling relationships between extra-cellular inputs and downstream molecular response mechanisms

M. Shahriar Hossain; Joseph Gresock; Yvette Edmonds; Richard Helm; Malcolm Potts; Naren Ramakrishnan

2012-01-01

314

Leishmaniasis - Multiple Languages: MedlinePlus  

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... sharing features on this page, please enable JavaScript. Leishmaniasis - Multiple Languages Arabic (???????) Spanish (español) Arabic (???????) Leishmaniasis Infection English (Arabic) ?????????? ?? ??? ??? - ??????? ...

315

Welcome to MedlinePlus en español  

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... salud Web site. Don Francisco, the popular Hispanic television host, recently announced a new joint effort with ... the world." The new public service campaign, including television and radio announcements featuring Don Francisco, will target ...

316

Bone Diseases - Multiple Languages: MedlinePlus  

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... Languages Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian ( ... Chinese - Traditional) Bilingual PDF Health Information Translations French (français) Bone Scan Scintigraphie osseuse - français (French) Bilingual PDF ...

317

Brain Diseases - Multiple Languages: MedlinePlus  

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318

Breathing Problems - Multiple Languages: MedlinePlus  

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319

Brain Cancer - Multiple Languages: MedlinePlus  

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320

Flu - Multiple Languages: MedlinePlus  

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... Japanese (???) Khmer (Khmer) Korean (???) Laotian (Lao) Polish (polski) Portuguese (português) Punjabi (??????) Romanian (Român?) ... Health - Seattle and King County Return to top Polish (polski) Inactivated Influenza Vaccine English Inaktywowana Szczepionka Przeikwo ...

321

Childhood Immunization - Multiple Languages: MedlinePlus  

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... Japanese (???) Khmer (Khmer) Korean (???) Laotian (Lao) Polish (polski) Portuguese (português) Punjabi (??????) Romanian (Român?) ... for Disease Control and Prevention Return to top Polish (polski) Haemophilus Influenzae Type b (Hib) Vaccine English ...

322

Phenylketonuria - Multiple Languages: MedlinePlus  

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323

Healthy Aging - Multiple Languages: MedlinePlus  

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... ????) Spanish (español) Chinese - Simplified (????) Secrets of Longevity English ????? - ???? (Chinese - Simplified) PDF Chinese Community Health Resource Center Chinese - Traditional (????) Secrets of Longevity English ????? - ???? (Chinese - Traditional) PDF Chinese Community ...

324

Fire Safety - Multiple Languages: MedlinePlus  

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325

Heat Illness - Multiple Languages: MedlinePlus  

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... ????) Somali (af Soomaali) Spanish (español) Arabic (???????) Heat Waves English (Arabic) ??????? ?????? - ??????? Multimedia Healthy Roads Media Bosnian (Bosanski) Heat Waves English Toplotni talasi - Bosanski (Bosnian) Multimedia Healthy Roads ...

326

Botulism - Multiple Languages: MedlinePlus  

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327

Safety - Multiple Languages: MedlinePlus  

MedlinePLUS

... Bosanski) Somali (af Soomaali) Spanish (español) Arabic (???????) Natural Gas Emergencies English (Arabic) ??????? ???????? ?????? ??????? - ??????? Multimedia Healthy Roads Media Bosnian (Bosanski) Natural Gas Emergencies English Slu?ajevi neposredne opasnosti sa prirodnim gasom - ...

328

Toddler Nutrition - Multiple Languages: MedlinePlus  

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... Part 1) English myanmasa (Burmese) Multimedia Healthy Roads Media Feeding Children the Right Message (Part 2) English myanmasa (Burmese) Multimedia ... 1) English ?????? (Nepali) Multimedia Healthy Roads Media Feeding Children the Right Message (Part 2) English ?????? (Nepali) ...

329

Health Information in Nepali (??????): MedlinePlus  

MedlinePLUS

... 1) - English ?????? (Nepali) Multimedia Healthy Roads Media Feeding Children the Right Message (Part 2) - English ?????? (Nepali) ... 1) - English ?????? (Nepali) Multimedia Healthy Roads Media Feeding Children the Right Message (Part 2) - English ?????? (Nepali) ...

330

Child Nutrition - Multiple Languages: MedlinePlus  

MedlinePLUS

... Part 1) English myanmasa (Burmese) Multimedia Healthy Roads Media Feeding Children the Right Message (Part 2) English myanmasa (Burmese) Multimedia ... 1) English ?????? (Nepali) Multimedia Healthy Roads Media Feeding Children the Right Message (Part 2) English ?????? (Nepali) ...

331

Nutrition - Multiple Languages: MedlinePlus  

MedlinePLUS

... Tagalog (Tagalog) Serve Up a Healthy Life - Give the Gift of Good Nutrition Nais ng mga Pilipino ang Malusog na Puso - Tagalog (Tagalog) Bilingual PDF National Heart, Lung, and Blood Institute Return to top Date ...

332

Heart Diseases - Multiple Languages: MedlinePlus  

MedlinePLUS

... Tagalog (Tagalog) Serve Up a Healthy Life - Give the Gift of Good Nutrition Nais ng mga Pilipino ang Malusog na Puso - Tagalog (Tagalog) Bilingual PDF National Heart, Lung, and Blood Institute Return to top Ukrainian ( ...

333

Health Information in Russian (???????): MedlinePlus  

MedlinePLUS

... Russian) Bilingual PDF Health Information Translations PFT (Pulmonary Function Test) PFT (???? ???????? ???????) - ??????? (Russian) Bilingual ... Russian) Multimedia Healthy Roads Media Pain Relievers PCA (Patient Controlled Analgesia) Pump ????? ??????????????? ????????????? ???????? - ??????? ( ...

334

Fever - Multiple Languages: MedlinePlus  

MedlinePLUS

... ????) French (français) Japanese (???) Korean (???) Portuguese (português) Russian (???????) Somali (af Soomaali) Spanish (español) Tagalog ( ... PDF Health Information Translations Return to top Portuguese (português) Taking a Temperature Como medir a temperatura - português ( ...

335

Common Cold - Multiple Languages: MedlinePlus  

MedlinePLUS

... ????) French (français) Hmong (Hmoob) Khmer (Khmer) Portuguese (português) Russian (???????) Spanish (español) Tagalog (Tagalog) Vietnamese (Tiê?ng ... Disease Control and Prevention Return to top Portuguese (português) Cover Your Cough English Cubrase quando tossir - português ( ...

336

Gallbladder Diseases - Multiple Languages: MedlinePlus  

MedlinePLUS

... Hindi (??????) Japanese (???) Korean (???) Portuguese (português) Russian (???????) Somali (af Soomaali) Spanish (español) Ukrainian ( ... PDF Health Information Translations Return to top Portuguese (português) Gall Bladder Removal Surgery Cirurgia para remoção da ...

337

Cancer Chemotherapy - Multiple Languages: MedlinePlus  

MedlinePLUS

... Bosnian (Bosanski) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Khmer (Khmer) ... Bilingual PDF Health Information Translations Return to top French (français) Chemotherapy Chimiothérapie - français (French) Bilingual PDF Health ...

338

Tuberculosis - Multiple Languages: MedlinePlus  

MedlinePLUS

... Bosnian (Bosanski) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Hmong (Hmoob) Japanese (???) ... Chinese Community Health Resource Center Return to top French (français) Do I Need a TB Skin Test? ...

339

Laboratory Tests - Multiple Languages: MedlinePlus  

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... Arabic (???????) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Khmer (Khmer) ... Chinese Community Health Resource Center Return to top French (français) 24-Hour Urine Test Test d'urine ...

340

Thalassemia - Multiple Languages: MedlinePlus  

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341

Earthquakes - Multiple Languages: MedlinePlus  

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... sharing features on this page, please enable JavaScript. Earthquakes - Multiple Languages Haitian Creole (Kreyol) Spanish (español) Haitian ... Kreyol) Parent Guidelines for Helping Children After an Earthquake English Konsèy pou paran ka ede timoun yo ...

342

Diets - Multiple Languages: MedlinePlus  

MedlinePLUS

... ????) Spanish (español) Chinese - Simplified (????) Low Fat, Low Cholesterol Diet English ????????? - ???? (Chinese - Simplified) PDF Chinese Community Health Resource Center Chinese - Traditional (????) Low Fat, Low Cholesterol Diet English ????????? - ???? (Chinese - Traditional) PDF Chinese Community ...

343

Healthlines | NIH MedlinePlus the Magazine  

MedlinePLUS

... HealthLines Past Issues / Summer 2012 Table of Contents Colorectal Cancer Screening: Just Do It New research shows that ... called flexible sigmoidoscopy can reduce the risk of colorectal cancer. It's different than a colonoscopy, which is considered ...

344

Tornadoes - Multiple Languages: MedlinePlus  

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... sharing features on this page, please enable JavaScript. Tornadoes - Multiple Languages Arabic (???????) Bosnian (Bosanski) Somali (af Soomaali) Spanish (español) Arabic (???????) Tornadoes English (Arabic) ???????? - ??????? PDF Healthy Roads Media ...

345

NIH MedlinePlus Advisory Group  

MedlinePLUS

... National Library of Medicine Trish Reynolds Writer-Editor/Media Liaison National Institute of Arthritis & Musculoskeletal and Skin Diseases Mark Siegal Communications & Public Liaison Branch National Institute of Alcohol Abuse and Alcoholism Ann Taubenheim Chief, Health Campaigns ...

346

MedlinePlus Connect in Use  

MedlinePLUS

... Northern IL Buffalo Medical Group, P.C. Buffalo, NY Cleveland Clinic Cleveland, OH Halifax Regional Medical Center ... recognized Tribes Institute for Family Health New York, NY LSU Health New Orleans and Shreveport, LA NewYork- ...

347

MedlinePlus.gov (medlineplus) on Twitter  

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348

Drug Abuse - Multiple Languages: MedlinePlus  

MedlinePLUS

... Sgaw Karen) Korean (???) Nepali (??????) Portuguese (português) Russian (???????) Somali (af Soomaali) Spanish (español) Tagalog ( ... Multimedia Healthy Roads Media Return to top Portuguese (português) Substance Abuse or Dependence Abuso ou dependência de ...

349

Joint Disorders - Multiple Languages: MedlinePlus  

MedlinePLUS

... Hindi (??????) Japanese (???) Korean (???) Portuguese (português) Russian (???????) Somali (af Soomaali) Spanish (español) Tagalog ( ... PDF Health Information Translations Return to top Portuguese (português) Home Care After Total Joint Replacement Cuidados em ...

350

Knee Replacement - Multiple Languages: MedlinePlus  

MedlinePLUS

... Hindi (??????) Japanese (???) Korean (???) Portuguese (português) Russian (???????) Somali (af Soomaali) Spanish (español) Tagalog ( ... PDF Health Information Translations Return to top Portuguese (português) Total Knee Replacement Substituição total do joelho - português ( ...

351

Hip Replacement - Multiple Languages: MedlinePlus  

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... Hindi (??????) Japanese (???) Korean (???) Portuguese (português) Russian (???????) Somali (af Soomaali) Spanish (español) Tagalog ( ... PDF Health Information Translations Return to top Portuguese (português) Total Hip Replacement Substituição total de quadril - português ( ...

352

Head Lice - Multiple Languages: MedlinePlus  

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353

Plague - Multiple Languages: MedlinePlus  

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354

Chlamydia Infections - Multiple Languages: MedlinePlus  

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355

Health Information in Hindi (??????): MedlinePlus  

MedlinePLUS

... ?????? (Hindi) Bilingual PDF Health Information Translations Nuclear Scans Bone Scan ?????? (Hindi) Bilingual PDF ... ?????? (Hindi) Bilingual PDF Health Information Translations Nuclear or Radiation Emergencies ?????? (Hindi) Bilingual PDF ...

356

Health Information in Japanese (???): MedlinePlus  

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... ??????? - ??? (Japanese) Bilingual PDF Health Information Translations Nuclear Scans Bone Scan ????? - ??? (Japanese) Bilingual PDF ... ?? - ??? (Japanese) Bilingual PDF Health Information Translations Nuclear or Radiation Emergencies ?????????????? - ??? (Japanese) Bilingual PDF ...

357

Health Information in Ukrainian (??????????): MedlinePlus  

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... ?????? - ?????????? (Ukrainian) Bilingual PDF Health Information Translations Concussion Types of Brain Injury ???? ????? ????????? ????? - ... ??????? - ?????????? (Ukrainian) Bilingual PDF Health Information Translations Mobility Aids Crutch Walking ??????? ?? ??????? - ?????????? (Ukrainian) ...

358

Dental Health - Multiple Languages: MedlinePlus  

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... Dental Care English ?????????? - ???? (Chinese - Traditional) PDF Chinese Community Health Resource Center Return to top Russian (???????) Concerns and Discomforts of Pregnancy (Oral Health) English ???????? ? ?????????? ??? ???????????? - ...

359

Scabies - Multiple Languages: MedlinePlus  

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360

Alcoholism - Multiple Languages: MedlinePlus  

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... Bosanski) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) Portuguese ( ... PDF Health Information Translations Return to top French (français) Substance Abuse or Dependence Toxicomanie ou dépendance - français ( ...

361

Ulcerative Colitis - Multiple Languages: MedlinePlus  

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... Multiple Languages Arabic (???????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian ( ... PDF Health Information Translations Return to top French (français) Echocardiogram Échocardiogramme - français (French) Bilingual PDF Health Information ...

362

Kidney Diseases - Multiple Languages: MedlinePlus  

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363

Lung Diseases - Multiple Languages: MedlinePlus  

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... ???????) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian ( ... Community Health Resource Center Return to top French (français) Bronchoscopy Bronchoscopie - français (French) Bilingual PDF Health Information ...

364

Radiation Therapy - Multiple Languages: MedlinePlus  

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... Bosanski) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) Portuguese ( ... PDF Health Information Translations Return to top French (français) Preventing Infections When Your White Blood Cell Count ...

365

Thyroid Diseases - Multiple Languages: MedlinePlus  

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... ???????) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Japanese (???) Korean (???) Russian (???????) Somali (af ... PDF Health Information Translations Return to top French (français) Thyroid Biopsy Biopsie thyroïdienne - français (French) Bilingual PDF ...

366

Swallowing Disorders - Multiple Languages: MedlinePlus  

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... Languages Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian ( ... Chinese - Traditional) Bilingual PDF Health Information Translations French (français) Barium Swallow Déglutition barytée - français (French) Bilingual PDF ...

367

Radiation Exposure - Multiple Languages: MedlinePlus  

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... Radiation Exposure - Multiple Languages Chinese - Traditional (????) French (français) German (Deutsch) Korean (???) Russian (???????) Spanish (español) ... PDF Centers for Disease Control and Prevention French (français) Acute Radiation Syndrome English Syndrome d'irradiation aiguë - ...

368

Neurologic Diseases - Multiple Languages: MedlinePlus  

MedlinePLUS

... Neurologic Diseases - Multiple Languages Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian ( ... Chinese - Traditional) Bilingual PDF Health Information Translations French (français) ... EEG (Électroencéphalogramme) - français (French) Bilingual PDF ...

369

Gout - Multiple Languages: MedlinePlus  

MedlinePLUS

... ??????? Multimedia Patient Education Institute Chinese - Simplified (????) Purine Restricted Diet (For Patients with Gout) English ??????? - ???? (Chinese - ... Chinese Community Health Resource Center Chinese - Traditional (????) Purine Restricted Diet (For Patients with Gout) English ??????? - ???? (Chinese - ...

370

Medication Errors - Multiple Languages: MedlinePlus  

MedlinePLUS

... sharing features on this page, please enable JavaScript. Medication Errors - Multiple Languages Chinese - Simplified (????) Chinese - Traditional (????) Spanish (español) Chinese - Simplified (????) Proper Use of Medications English ?????????? - ???? (Chinese - Simplified) PDF Chinese Community ...

371

Mining MEDLINE for the Treatment of Osteoporosis  

Microsoft Academic Search

In this paper, we consider the importance of osteoporosis disease in terms of medical research and pharmaceutical industry\\u000a and we introduce a knowledge discovery approach regarding the treatment of osteoporosis from a historical perspective. Osteoporosis\\u000a is a systemic skeletal disease in which osteoporotic fractures are associated with substantial morbidity and mortality and\\u000a impaired quality of life. Osteoporosis has also higher

Pinar Yildirim; Çinar Çeken; Reza Hassanpour; Sadik Esmelioglu; Mehmet Resit Tolun

372

Coronavirus Infections - Multiple Languages: MedlinePlus  

MedlinePLUS

... sharing features on this page, please enable JavaScript. Coronavirus Infections - Multiple Languages Chinese - Traditional (????) Japanese (???) ... Prevention Return to top Spanish (español) Infecciones por coronavirus Return to top Vietnamese (Tiê?ng Viê?t) Basic Information ...

373

Refractive Errors - Multiple Languages: MedlinePlus  

MedlinePLUS

... sharing features on this page, please enable JavaScript. Refractive Errors - Multiple Languages Chinese - Simplified (????) Chinese - Traditional (????) Spanish (español) Chinese - Simplified (????) Nearsightedness (Myopia) English ?? - ???? (Chinese - Simplified) PDF Chinese Community ...

374

Colonic Diseases - Multiple Languages: MedlinePlus  

MedlinePLUS

... JavaScript. Colonic Diseases - Multiple Languages Arabic (???????) French (français) Hindi (??????) Japanese (???) Khmer (Khmer) Korean ( ... ??? ?????? - ??????? Bilingual Health Information Translations French (français) Barium Enema Lavement baryté - français (French) Bilingual PDF ...

375

Health Information in Korean (???): MedlinePlus  

MedlinePLUS

... Action Coalition; Centers for Disease Control and Prevention Postpartum Care Your Recovery after Vaginal Birth ???? ? ?? - ??? (Korean) Bilingual PDF Health Information Translations Postpartum Depression Emotional Changes after Giving Birth ?? ? ...

376

Evidence-based surgery for cesarean delivery: an updated systematic review.  

PubMed

The objective of our systematic review was to provide updated evidence-based guidance for surgical decisions during cesarean delivery (CD). We performed an English-language MEDLINE, PubMed, and COCHRANE search with the terms, cesarean section, cesarean delivery, cesarean, pregnancy, and randomized trials, plus each technical aspect of CD. Randomized control trials (RCTs) involving any aspect of CD technique from Jan. 1, 2005, to Sept. 1, 2012, were evaluated to update a previous systematic review. We also summarized Cochrane reviews, systematic reviews, and metaanalyses if they included additional RCTs since this review. We identified 73 RCTs, 10 metaanalyses and/or systematic reviews, and 12 Cochrane reviews during this time frame. Recommendations with high levels of certainty as defined by the US Preventive Services Task Force favor pre-skin incision prophylactic antibiotics, cephalad-caudad blunt uterine extension, spontaneous placental removal, surgeon preference on uterine exteriorization, single-layer uterine closure when future fertility is undesired, and suture closure of the subcutaneous tissue when thickness is 2 cm or greater and do not favor manual cervical dilation, subcutaneous drains, or supplemental oxygen for the reduction of morbidity from infection. The technical aspect of CD with high-quality, evidence-based recommendations should be adopted. Although 73 RCTs over the past 8 years is encouraging, additional well-designed, adequately powered trials on the specific technical aspects of CD are warranted. PMID:23467047

Dahlke, Joshua D; Mendez-Figueroa, Hector; Rouse, Dwight J; Berghella, Vincenzo; Baxter, Jason K; Chauhan, Suneet P

2013-03-01

377

Searching for Controlled Trials of Complementary and Alternative Medicine: a Comparison of 15 Databases  

Microsoft Academic Search

This project aims to assess the utility of bibliographic databases beyond the three major ones (MEDLINE, EMBASE and Cochrane CENTRAL) for finding controlled trials of complemen- tary and alternative medicine (CAM). Fifteen databases were searched to identify controlled clinical trials (CCTs) of CAM not also indexed in MEDLINE. Searches were conducted in May 2006 using the revised Cochrane highly sensitive

Elise Cogo; Margaret Sampson; Isola Ajiferuke; Eric Manheimer; Kaitryn Campbell; Raymond Daniel; David Moher

2009-01-01

378

A concept analysis of person-centered care.  

PubMed

The term person-centered care (PCC) has been frequently used in the literature, but there is no consensus about its meaning. This article uses Walker and Avants's method of concept analysis as a framework to analyze PCC. A literature search was completed and data were collected using several search engines (CINAHL, Medline, PubMed, and Cochrane Review). The key words used were "individualized-care," "person-centered care," "patient-centered care," "client-centered care," and "resident-centered care." Attributes, antecedents, and consequences of PCC were identified. Empirical referents were provided to measure PCC from the perspective of the person receiving care and finally, a model case provides an exemplar of the concept. PMID:21772048

Morgan, Stephanie; Yoder, Linda H

2011-07-19

379

High Burden of Protein-Energy Malnutrition in Nigeria: Beyond the Health Care Setting  

PubMed Central

There is still a high burden of protein–energy malnutrition in Nigeria. The severe forms of the disease are usually associated with high level of mortality even in the tertiary health facilities. To review the cost-effective health promotional strategies at community levels that could aid prevention, early detection, and prompt treatment of protein–energy malnutrition. The strategy used for locating articles used for this review was to search databases like Google, Google scholar, relevant electronic journals from the universities’ libraries, including PubMed and Scirus, Medline, Cochrane library and WHO's Hinari. We believe that strategies beyond the health care setting have potential of significantly reducing the morbidity and mortality associated with protein–energy malnutrition in Nigeria.

Ubesie, AC; Ibeziakor, NS

2012-01-01

380

An Evidence-Based Review of Fat Modifying Supplemental Weight Loss Products  

PubMed Central

Objective. To review the literature on fat modifying dietary supplements commonly used for weight loss. Methods. Recently published randomized, placebo-controlled trials were identified in PubMed, MEDLINE, International Pharmaceutical Abstracts, Cochrane Database, and Google Scholar using the search terms dietary supplement, herbal, weight loss, obesity, and individual supplement names. Discussion. Data for conjugated linoleic acid (CLA), Garcinia cambogia, chitosan, pyruvate, Irvingia gabonensis, and chia seed for weight loss were identified. CLA, chitosan, pyruvate, and Irvingia gabonensis appeared to be effective in weight loss via fat modifying mechanisms. However, the data on the use of these products is limited. Conclusion. Many obese people use dietary supplements for weight loss. To date, there is little clinical evidence to support their use. More data is necessary to determine the efficacy and safety of these supplements. Healthcare providers should assist patients in weighing the risks and benefits of dietary supplement use for weight loss.

Egras, Amy M.; Hamilton, William R.; Lenz, Thomas L.; Monaghan, Michael S.

2011-01-01

381

An evidence-based review of fat modifying supplemental weight loss products.  

PubMed

Objective. To review the literature on fat modifying dietary supplements commonly used for weight loss. Methods. Recently published randomized, placebo-controlled trials were identified in PubMed, MEDLINE, International Pharmaceutical Abstracts, Cochrane Database, and Google Scholar using the search terms dietary supplement, herbal, weight loss, obesity, and individual supplement names. Discussion. Data for conjugated linoleic acid (CLA), Garcinia cambogia, chitosan, pyruvate, Irvingia gabonensis, and chia seed for weight loss were identified. CLA, chitosan, pyruvate, and Irvingia gabonensis appeared to be effective in weight loss via fat modifying mechanisms. However, the data on the use of these products is limited. Conclusion. Many obese people use dietary supplements for weight loss. To date, there is little clinical evidence to support their use. More data is necessary to determine the efficacy and safety of these supplements. Healthcare providers should assist patients in weighing the risks and benefits of dietary supplement use for weight loss. PMID:20847896

Egras, Amy M; Hamilton, William R; Lenz, Thomas L; Monaghan, Michael S

2010-08-10

382

Neuraxial opioid-induced pruritus: An update  

PubMed Central

Pruritus is a troublesome side-effect of neuraxial (epidural and intrathecal) opioids. Sometimes it may be more unpleasant than pain itself. The prevention and treatment still remains a challenge. A variety of medications with different mechanisms of action have been used for the prevention and treatment of opioid-induced pruritus, with mixed results. The aim of this article is to review the current body of literature and summarize the current understanding of the mechanisms and the pharmacological therapies available to manage opioid-induced pruritus. The literature source of this review was obtained via PubMed, Medline and Cochrane Database of Systematic Reviews until 2012. The search results were limited to the randomized controlled trials, systemic reviews and non-systemic reviews.

Kumar, Kamal; Singh, Sudha Indu

2013-01-01

383

Conservative management of congenital muscular torticollis: an evidence-based algorithm and preliminary treatment parameter recommendations.  

PubMed

ABSTRACT Purpose: To present an algorithm with accompanying treatment parameters for the management of congenital muscular torticollis (CMT) based on the best available literature. Methods: A systematic search of PubMed, MEDLINE, CINHAL, and Cochrane databases was conducted to identify evidence to guide the conservative management of CMT. Results: An evidence-based algorithm was created based on three prognostic factors that influence treatment duration and outcome, including a sternocleidomastoid fibrotic mass, passive range of motion rotation deficit, and age at initiation of treatment. Preliminary treatment parameter recommendations for clinic and home programming accompany the algorithm. Conclusion: Use of the proposed evidence-based algorithm with accompanying preliminary treatment parameter recommendations may improve consistency of care and outcomes for infants with CMT. While a higher level of evidence supports the three prognostic factors utilized in the algorithm, research gaps continue to exist with regards to treatment parameters. PMID:23387981

Christensen, Catie; Landsettle, Angela; Antoszewski, Sandra; Ballard, B Blaire; Carey, Helen; Pax Lowes, Linda

2013-02-06

384

Minimally Invasive Versus Open Esophagectomy: Meta-Analysis of Outcomes  

Microsoft Academic Search

Background  A meta-analysis of the current literature was performed to compare the perioperative outcome measures and oncological impact\\u000a between minimally invasive and open esophagectomy.\\u000a \\u000a \\u000a \\u000a \\u000a Methods  Using the electronic databases Medline, Embase, Pubmed and the Cochrane Library, we performed a meta-analysis pooling the\\u000a effects of outcomes of 1,008 patients enrolled into eight comparative studies, using classic and modern meta-analytic methods.\\u000a \\u000a \\u000a \\u000a \\u000a Results  Two comparisons were

George Sgourakis; Ines Gockel; Arnold Radtke; Thomas J. Musholt; Stephan Timm; Andreas Rink; Achilleas Tsiamis; Constantine Karaliotas; Hauke Lang

2010-01-01

385

Effects of Sophora japonica flowers (Huaihua) on cerebral infarction  

PubMed Central

The dried flowers and buds of Sophora japonica are used as a medicinal herb in China, Japan and Korea to treat bleeding hemorrhoids and hematemesis. This article presents an overview of the effects of Sophora japonica on cerebral infarction based on literature searched from Medline, PubMed, Cochrane Library and the China National Knowledge Infrastructure (CNKI). Sophora japonica contains both anti-hemorrhagic and anti-hemostatic substances. Sophora japonica reduces cerebral infarction partly as a result of its anti-oxidative and anti-inflammatory activities. Previous studies found that Sophora japonica reduced the size of cerebral infarction and neurological deficits and reduced microglial activation, interleukin-1? release and number of apoptotic cells in ischemia-reperfusion injured Sprague-Dawley rats. Further study is required to determine the relationship between Sophora japonica-mediated reduction in cerebral infarction size and the effects of Sophora japonica on platelet aggregation and cardiovascular function.

2010-01-01

386

Evidence-based labor and delivery management.  

PubMed

Our objective was to provide evidence-based guidance for management decisions during labor and delivery. We performed MEDLINE, PubMed, and COCHRANE searches with the terms labor, delivery, pregnancy, randomized trials, plus each management aspect of labor and delivery (eg, early admission). Each management step of labor and delivery was reviewed separately. Evidence-based good quality data favor hospital births, delayed admission, support by doula, training birth assistants in developing countries, and upright position in the second stage. Home-like births, enema, shaving, routine vaginal irrigation, early amniotomy, "hands-on" method, fundal pressure, and episiotomy can be associated with complications without sufficient benefits and should probably be avoided. We conclude that labor and delivery interventions supported by good quality data as just described should be routinely performed. All aspects with lower data quality should be researched with adequately powered and designed trials. PMID:18984077

Berghella, Vincenzo; Baxter, Jason K; Chauhan, Suneet P

2008-11-01

387

The interactions between hemostasis and resistance training: a review.  

PubMed

Physical inactivity is considered a risk factor for cardiovascular disease and is strongly associated with changes in arterial structure. Regular physical activity and exercise contributes to the prevention of coronary artery disease. Therefore, cardiovascular and resistance training improve hemostatic parameters and promote a less thrombotic blood profile. This review highlights the studies, mechanisms, and outcomes relating to the effectiveness of resistance training on the process of hemostasis. The Pubmed, Scopus, Medline, Scielo, Lilacs, Ibecs, and Cochrane databases were used to locate the original articles. Seventeen studies were found during the research process. Of these, ten articles were excluded. Those protocols using a high volume of training for young adults showed a greater fibrinolytic response, and training protocols with intensities above 80% of 1 maximum repetition showed an increased platelet activity. In subjects with coronary artery disease, just one session of resistance training resulted in improvement in the fibrinolytic system (tissue plasminogen activator) without raising potential thrombotic markers. PMID:22419885

Nascimento, Dahan da Cunha; Neto, Frederico Ribeiro; de Santana, Frederico Santos; da Silva, Renato André Sousa; Dos Santos-Neto, Leopoldo; Balsamo, Sandor

2012-03-09

388

The effectiveness of walking as an intervention for low back pain: a systematic review  

PubMed Central

As current low back pain (LBP) guidelines do not specifically advocate walking as an intervention, this review has explored for the effectiveness of walking in managing acute and chronic LBP. CINAHL, Medline, AMED, EMBASE, PubMed, Cochrane and Scopus databases, as well as a hand search of reference lists of retrieved articles, were searched. The search was restricted to studies in the English language. Studies were included when walking was identified as an intervention. Four studies met inclusion criteria, and were assessed with a quality checklist. Three lower ranked studies reported a reduction in LBP from a walking intervention, while the highest ranked study observed no effect. Heterogeneity of study design made it difficult to draw comparisons between studies. There is only low–moderate evidence for walking as an effective intervention strategy for LBP. Further investigation is required to investigate the strength of effect for walking as a primary intervention in the management of acute and chronic LBP.

Hendrick, P.; Te Wake, A. M.; Tikkisetty, A. S.; Wulff, L.; Yap, C.

2010-01-01

389

Adherence to nutritional therapy in obese adolescents; a review.  

PubMed

Considering the controversies existent on the subject, the aim of this review is to discuss adherence to diet in obese adolescents. The selection of articles was made in the SCOPUS, COCHRANE, APA Psyc Net, SciELO, LILACS, CAPES Journals, PUBMED/MEDLINE and GOOGLE ACADEMIC databases. Studies published between 2002 and 2012 were selected. There was lack of evidence of conceptual discussion about adherence to diet in obesity in the child-youth context, in addition to scarcity of data on adherence to diet itself in obese adolescents and the methods of evaluating this. Lastly, multiple interdependent factors were found which both facilitated and made the process of adherence to diet difficult for obese youngsters. The majority of these (factors) belong to the socioeconomic and cultural dimension, in addition to pointing out cognitive and psychological factors and those associated with health services and professionals. PMID:23889613

França, Silvana Lima Guimarães; Sahade, Viviane; Nunes, Mônica; Adan, Luis F

390

NIH Quickfinder and NIH Medline Plus Advisory Group | NIH MedlinePlus the Magazine  

MedlinePLUS

... ex-officio) Lakshmi Grama, National Cancer Institute Susan Johnson, National Institute of Dental and Craniofacial Research Thomas Johnson, National Institute of Biomedical Imaging and Bioengineering Kathy ...

391

Knowledge for Knowledge Translation: The Role of the Cochrane Collaboration  

ERIC Educational Resources Information Center

Knowledge-translation (KT) activities, including continuing education, should be informed by the totality of available research evidence. Systematic reviews are a generic methodology used to synthesize evidence from a broad range of research methods addressing different questions. Over the past decade, there has been a dramatic increase in the…

Grimshaw, Jeremy M.; Santesso, Nancy; Cumpston, Miranda; Mayhew, Alain; McGowan, Jessie

2006-01-01

392

Phil Cochran and John Alison: Images of Apollo's Warriors.  

National Technical Information Service (NTIS)

This study attempts to determine those World War II unconventional warfare leadership attributes that might help us in selecting today's special operations leaders. In doing so, the author first develops a template of special operations leadership qualiti...

R. W. Boltz

2001-01-01

393

Sexual and gender-based violence in areas of armed conflict: a systematic review of mental health and psychosocial support interventions  

PubMed Central

Background Sexual and other forms of gender-based violence are common in conflict settings and are known risk factors for mental health and psychosocial wellbeing. We present findings from a systematic review of the academic and grey literature focused on the effectiveness of mental health and psychosocial support interventions for populations exposed to sexual and other forms of gender-based violence in the context of armed conflicts. Methods We searched the Cochrane Database of Systematic Reviews, Cochrane Controlled Trials Register, PubMed/ Medline, psycINFO, and PILOTS, as well as grey literature to search for evaluations of interventions, without date limitations. Results Out of 5,684 returned records 189 full text papers were assessed for eligibility. Seven studies met inclusion criteria: 1 non-randomized controlled study; 3 non-controlled pre- post-test designs; 1 retrospective cohort with a matched comparison group; and 2 case studies. Studies were conducted in West and Central Africa; Albania; UK and USA, included female participants, and focused on individual and group counseling; combined psychological, medical, social and economic interventions; and cognitive behavioral therapy (two single case studies). Conclusions The seven studies, while very limited, tentatively suggest beneficial effects of mental health and psychosocial interventions for this population, and show feasibility of evaluation and implementation of such interventions in real-life settings through partnerships with humanitarian organizations. Robust conclusions on the effectiveness of particular approaches are not possible on the basis of current evidence. More rigorous research is urgently needed.

2013-01-01

394

New approach to managing genital warts  

PubMed Central

Abstract Objective To summarize and determine the appropriate use for the new and old management tools for genital warts. Sources of information The following databases were searched: MEDLINE, PubMed, EMBASE, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, ACP Journal Club, and Trip. The bibliographies of retrieved papers were also reviewed. Clinical trials, qualitative review articles, consensus reports, and clinical practice guidelines were retrieved. Main message Symptomatic warts are prevalent in at least 1% of the population between the ages of 15 and 49, with estimates of up to 50% of the population being infected with human papillomavirus at some point in their lifetime. Imiquimod and podophyllotoxin are 2 new treatments for external genital warts that are less painful and can be applied by patients at home. In addition, the quadrivalent human papillomavirus vaccine has been shown to be efficacious in preventing genital warts and cervical cancer. There is still a role for the older treatment methods in certain situations, such as intravaginal, urethral, anal, or recalcitrant warts; or for pregnant patients. Conclusion The new treatments of external genital warts can reduce the pain of treatment and the number of office visits. Other treatment methods are still useful in certain situations.

Lopaschuk, Catharine C.

2013-01-01

395

Evidence-based medicine in dermatology.  

PubMed

EBM is the use of the best current evidence in making decisions about the care of individual patients. Practicing EBM requires five steps: (1) formulating well-built clinical questions, (2) finding the best evidence to answer the questions, (3) critically appraising the evidence, (4) applying the evidence to specific patients, and (5) saving the critically appraised evidence. The Cochrane Library is the best source for finding the best evidence about treatment. The second best method for finding evidence about treatment and the best source for finding most other types of best evidence in dermatology is by searching the MEDLINE database using the PubMed Clinical search engine of the National Library of Medicine (http://++www.ncbi.nlm.nih.gov/PubMed/clin ica l.html). MEDLINE searches have inherent software and operator limitations that make their reliability quite variable. The quality (strength) of evidence is based on a hierarchy of evidence: results of systematic reviews of well-designed clinical studies, results of one or more well-designed clinical studies, results of large case series, and expert opinion. Once the best evidence has been found, the EBM approach involves critically appraising the quality of the evidence, determining its magnitude and precision, and applying it to the specific patient. Guidelines to appraise critically and apply evidence are available. The clinical question, best evidence, and its critical appraisal should be saved in a format that can be easily retrieved for future use. PMID:10791153

Bigby, M

2000-04-01

396

Use of virtual reality systems as proprioception method in cerebral palsy: clinical practice guideline.  

PubMed

INTRODUCTION: The limitations in performing functional activities in children and adolescents with cerebral palsy are important. The use of virtual reality systems is a new treatment approach that reinforces task-oriented motor learning. The purpose of this guide is to study the impact of the use of virtual reality systems in the improvement and acquisition of functional skills, and to evaluate the scientific evidence to determine the strength of recommendation of such interventions. DEVELOPMENT: All available full-text articles, regardless of their methodology, were included. The following data bases were consulted: PubMed (Medline), PEDro, EMBASE (OVID-Elsevier), Cochrane Library, Medline (OVID), CINAHL, ISI Web Knowledge. An assessment was made of methodological quality, the level of scientific evidence, and the strength of recommendations using the tools: Critical Review Form - Quantitative Studies and the Guidelines for Critical Review Form - Quantitative Studies and U.S. Preventive Services Task Force. Finally, we included 13 articles and 97 participants were recruited. We obtained significant improvements in outcome measures that assessed postural control and balance, upper limb function, the selective joint control, and gait. CONCLUSIONS: The guide has some limitations: the limited number of patients enrolled, clinical diversity and age range, as well as the methodological quality of existing trials. Virtual reality is a promising tool in the treatment of children with cerebral palsy. There is strong scientific evidence of an acceptable recommendation for the use of virtual reality systems in the treatment of cerebral palsy. PMID:22341675

Monge Pereira, E; Molina Rueda, F; Alguacil Diego, I M; Cano De La Cuerda, R; De Mauro, A; Miangolarra Page, J C

2012-02-16

397

Lower dental caries prevalence associated to chronic kidney disease: a systematic review.  

PubMed

BACKGROUND: The aim of this systematic review was to determine whether there is any evidence in the literature referring to a lower prevalence of dental caries in children and adolescents with chronic kidney disease (CKD) compared to healthy individuals. METHODS: A search of the PubMed Medline, Ovid Medline and Cochrane Library databases was performed using the MeSH terms "dental caries" and "chronic renal failure". To be eligible for entry in our study, controlled observational studies had to present a decayed, missing and filled index for primary teeth (dmft) and/or for permanent teeth (DMFT) in children and adolescents with CKD. RESULTS: After evaluation of title, keywords and abstracts of the articles selected, six articles met the inclusion criteria. Three of these six articles included studies which showed susceptibility to bias and possible confounding factors. A subsequent assessment of the six studies revealed that the mean caries indices in both primary (dmf) and permanent (DMF) teeth were lower in the children and adolescents with CKD compared with healthy individuals. CONCLUSION: Data in the literature weakly support a lower prevalence of caries in children and adolescents with CKD than in their healthy counterparts. There is still a lack of well-designed studies that provide better scientific evidence in support of this conclusion. PMID:23595424

Andrade, Marcia Rejane Thomas Canabarro; Antunes, Lívia Azeredo Alves; Soares, Rosangela Maria de Araújo; Leão, Anna Theresa Tome; Maia, Luciane Cople; Primo, Laura Guimarães

2013-04-18

398

Online Medical Literature Consultation Habits of Academic Teaching Physicians in the EU and CIS Countries: A Cross-Sectional Study  

PubMed Central

Background Both in the Commonwealth of Independent States (CIS) and in the European Union (EU2004), ample availability of up to date medical scientific literature is important for progress in medical science and for the education of the next generation of healthcare workers. The aim of this research is to assess if the use of online medical literature among academic teaching (AT) physicians is at the same level in the CIS as in the EU2004. Methodology/Principal Findings In the capital cities of the CIS and the EU2004 member states, AT physicians holding an academic position at least equivalent to an associate professor and performing the three classical tasks in academic medicine (teaching, research and patient care) were interviewed about their use of and familiarity with the Internet and 9 online literature services, including journals and bibliographical databases such as PubMed (Medline), The Cochrane Library and Web of Science. Library staff members were interviewed about the availability of these online literature services at their libraries. About 750 physicians and 40 library staff members were invited for participation. Eventually 124 AT physicians and 22 library staff members participated. Internet was everywhere available, but used daily by more AT physicians in the EU2004 (71% versus 48% in the CIS, P?=?.005). AT physicians in the EU2004 accessed a higher percentage of all articles online (74% versus 43% in the CIS, P<.001). PubMed (P<.001), The Cochrane Library (P<.001) and Web of Science (P<.003) were used more frequently in the EU2004. In the EU2004 more AT physicians were familiar with Open Access journals (89% versus 51% in the CIS, P<.001). Conclusions/Significance AT physicians in the CIS use online medical literature less than in the EU2004. It is recommended that the awareness of freely available online literature services such as Open Access journals is enhanced among AT physicians and library staff members, especially in the CIS.

van der Voort, Chiel T. M.; Swenne, Cees A.; van der Hoorn-van Velthoven, Catharina A. M.; Belt, Johannes H. J.

2012-01-01

399

How good is endoscopic ultrasound for TNM staging of gastric cancers? A meta-analysis and systematic review  

PubMed Central

AIM: To evaluate the accuracy of endoscopic ultrasound (EUS) for staging of gastric cancers. METHODS: Only EUS studies confirmed by surgery were selected. Only studies from which a 2 × 2 table could be constructed for true positive, false negative, false positive and true negative values were included. Articles were searched in Medline, Pubmed, Ovid journals, Cumulative index for nursing & allied health literature, International pharmaceutical abstracts, old Medline, Medline nonindexed citations, and Cochrane control trial registry. Two reviewers independently searched and extracted data. The differences were resolved by mutual agreement. 2 × 2 tables were constructed with the data extracted from each study. Meta-analysis for the accuracy of EUS was analyzed by calculating pooled estimates of sensitivity, specificity, likelihood ratios, and diagnostic odds ratio. Pooling was conducted by both the Mantel-Haenszel method (fixed effects model) and DerSimonian Laird method (random effects model). The heterogeneity of studies was tested using Cochran’s Q test based upon inverse variance weights. RESULTS: Initial search identified 1620 reference articles and of these, 376 relevant articles were selected and reviewed. Twenty-two studies (n = 1896) which met the inclusion criteria were included in this analysis. Pooled sensitivity of T1 was 88.1% (95% CI: 84.5-91.1) and T2 was 82.3% (95% CI: 78.2-86.0). For T3, pooled sensitivity was 89.7% (95% CI: 87.1-92.0). T4 had a pooled sensitivity of 99.2% (95% CI: 97.1-99.9). For nodal staging, the pooled sensitivity for N1 was 58.2% (95% CI: 53.5-62.8) and N2 was 64.9% (95% CI: 60.8-68.8). Pooled sensitivity to diagnose distant metastasis was 73.2% (95% CI: 63.2-81.7). The P for chi-squared heterogeneity for all the pooled accuracy estimates was > 0.10. CONCLUSION: EUS results are more accurate with advanced disease than early disease. If EUS diagnoses advanced disease, such as T4 disease, the patient is 500 times more likely to have true anatomic stage of T4 disease.

Puli, Srinivas Reddy; Reddy, Jyotsna Batapati Krishna; Bechtold, Matthew L; Antillon, Mainor R; Ibdah, Jamal A

2008-01-01

400

Prevention of and Therapies for Nipple Pain: A Systematic Review  

Microsoft Academic Search

Objective: To review the literature on nipple pain and to delineate effective strategies for the pre- vention and treatment of nipple pain in breastfeeding mothers. Data Sources: Computerized searches on MED- LINE, Pre-MEDLINE, CINAHL, and the Cochrane Library.

Kristine Morland-Schultz; Pamela D. Hill

401

Closing the Quality Gap: Revisiting the State of the Science. 8. Improving Health Care and Palliative Care for Advanced and Serious Illness. Evidence Report/Technology Assessment Number 208.  

National Technical Information Service (NTIS)

The objective is to systematically review the evidence on the effectiveness of health care and palliative care interventions to improve outcomes for patients with advanced and serious illness. We searched MEDLINE, CINAHL, PsycINFO, Cochrane, and DARE from...

2012-01-01

402

Endoscopic ultrasound: It's accuracy in evaluating mediastinal lymphadenopathy? A meta-analysis and systematic review  

PubMed Central

AIM: To evaluate the accuracy of endoscopic ultrasound (EUS), EUS-fine needle aspiration (FNA) in evaluating mediastinal lymphadenopathy. METHODS: Only EUS and EUS-FNA studies confirmed by surgery or with appropriate follow-up were selected. Articles were searched in Medline, Pubmed, and Cochrane control trial registry. Only studies from which a 2 × 2 table could be constructed for true positive, false negative, false positive and true negative values were included. Two reviewers independently searched and extracted data. The differences were resolved by mutual agreement. Meta-analysis for the accuracy of EUS was analyzed by calculating pooled estimates of sensitivity, specificity, likelihood ratios, and diagnostic odds ratios. Pooling was conducted by both Mantel-Haenszel method (fixed effects model) and DerSimonian Laird method (random effects model). The heterogeneity of studies was tested using Cochran’s Q test based upon inverse variance weights. RESULTS: Data was extracted from 76 studies (n = 9310) which met the inclusion criteria. Of these, 44 studies used EUS alone and 32 studies used EUS-FNA. FNA improved the sensitivity of EUS from 84.7% (95% CI: 82.9-86.4) to 88.0% (95% CI: 85.8-90.0). With FNA, the specificity of EUS improved from 84.6% (95% CI: 83.2-85.9) to 96.4% (95% CI: 95.3-97.4). The P for chi-squared heterogeneity for all the pooled accuracy estimates was > 0.10. CONCLUSION: EUS is highly sensitive and specific for the evaluation of mediastinal lymphadenopathy and FNA substantially improves this. EUS with FNA should be the diagnostic test of choice for evaluating mediastinal lymphadenopathy.

Puli, Srinivas R; Reddy, Jyotsna Batapati Krishna; Bechtold, Matthew L; Ibdah, Jamal A; Antillon, Daphne; Singh, Shailender; Olyaee, Mojtaba; Antillon, Mainor R

2008-01-01

403

Although leukoplakia responds to some treatments relapses and adverse effects are common  

Microsoft Academic Search

Data sourcesThe Cochrane Oral Health Group's Trials Register, Cochrane Central Trials Register, Medline and Embase were searched, as well as the following journals: Cancer, Community Dentistry and Oral Epidemiology, European Journal of Oral Sciences, Journal of Dental Research, Oral Oncology, Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics. The reference lists of included studies and reviews were checked,

Shailesh Lele

2005-01-01

404

Insufficient evidence to support or refute the need for 6-monthly dental check-ups. What is the optimal recall frequency between dental checks?  

Microsoft Academic Search

DATA SOURCES: Trials were sourced using the Cochrane Oral Health Group Trials Register, the Cochrane Central Register of Controlled Trials, Medline and Embase. Reference lists from relevant articles were scanned and the authors of some papers were contacted to identify further trials and obtain additional information. STUDY SELECTION: Trials were selected if they met the following criteria:design: random allocation of

Th. G. P. H. Mettes

2005-01-01

405

A Review of the Literature on Osteonecrosis of the Jaw in Patients with Osteoporosis Treated with Oral Bisphosphonates: Prevalence, Risk Factors, and Clinical Characteristics  

Microsoft Academic Search

Objective: This literature review was performed to elucidate the relationship between bisphosphonate use and development of osteonecrosis of the jaw (ONJ) in patients receiving oral bisphosphonates for the treatment of osteoporosis.Methods: MEDLINE, the Cochrane Database of Systematic Reviews, the Cochrane Central Register of Controlled Trials, and EMBASE were searched for English-language articles published from 1966 to September 2006 whose titles

Michael Pazianas; Paul Miller; William A. Blumentals; Myriam Bernal; Prajesh Kothawala

2007-01-01

406

Which filling material is best in the primary dentition?  

Microsoft Academic Search

Data SourcesThe Cochrane Oral Health Group's specialised trial register (Cochrane Central Register of Controlled Trials) was searched along with Medline, Embase and the System for Information on Grey Literature in Europe, along with proceedings from conferences on early childhood caries, restorative materials for paediatric dentistry, and material sciences conferences for dental materials used for children's dentistry. There were no language

Sergio Uribe

2010-01-01

407

What type of orthodontic retainer is best?  

Microsoft Academic Search

Data sources The Cochrane Oral Health Group's Trials Register, The Cochrane Central Register of Controlled Trials (CENTRAL), Medline and Embase were searched. Several journals were searched by hand (American Journal of Orthodontics and Dentofacial Orthopedics (formerly American Journal of Orthodontics), Angle Orthodontist European Journal of Orthodontics, Journal of Orthodontics (formerly British Journal of Orthodontics)). No language restrictions were applied. Authors

Kathy Russell

2004-01-01

408

Effectiveness and efficiency of guideline dissemination and implementation strategies  

Microsoft Academic Search

OBJECTIVES: To undertake a systematic review of the effectiveness and costs of different guideline development, dissemination and implementation strategies. To estimate the resource implications of these strategies. To develop a framework for deciding when it is efficient to develop and introduce clinical guidelines. DATA SOURCES: MEDLINE, Healthstar, Cochrane Controlled Trial Register, EMBASE, SIGLE and the specialised register of the Cochrane

JM Grimshaw; R. Thomas; G. MacLennan; C. Fraser; C. R. Ramsay; L. Vale; P. Whitty; M. P. Eccles; L. Matowe; L. Shirran; M. J. P. Wensing; R. F. Dijkstra; C. Donaldson

2004-01-01

409

Tacrolimus versus ciclosporin as primary immunosuppression for kidney transplant recipients: meta-analysis and meta-regression of randomised trial data  

Microsoft Academic Search

Objective To compare the positive and negative effects of tacrolimus and ciclosporin as initial treatment for renal transplant recipients. Design Systematic review. Data sources and study selection Reports of comparative randomised trials of tacrolimus and ciclosporin identified by searches of Medline, Embase, the Cochrane Register of Controlled Trials, the Cochrane Renal Group Specialist Register, and conference proceedings. Data extraction and

Angela C Webster; Rebecca C Woodroffe; Rod S Taylor; Jeremy R Chapman; Jonathan C Craig

2005-01-01

410

Staff training improved oral hygiene in patients following stroke  

Microsoft Academic Search

Data sourcesReports were identified using the Cochrane Stroke Group and Oral Health Group trials registers, the Cochrane CENTRAL trial register, Cochrane Library, Medline, Cinahl, Research Findings Electronic Register, National Research Register, ISI Science and Technology Proceedings, Dissertation Abstracts and Conference Papers Index, and the reference lists from relevant papers. Authors and researchers in the field were also contacted.Study selectionRandomised controlled

Maura Edwards

2008-01-01

411

Root resorption during orthodontic treatment  

Microsoft Academic Search

Data sourcesMedline, Embase, LILACS, The Cochrane Library (Cochrane Database of Systematic Reviews, CENTRAL, and Cochrane Oral Health Group Trials Register) Web of Science, EBM Reviews, Computer Retrieval of Information on Scientific Project (CRISP, www.crisp.cit.nih.gov), On-Line Computer Library Center (www.oclc.org), Google Index to Scientific and Technical Proceedings, PAHO (www.paho.org), WHOLis (www.who.int\\/library\\/databases\\/en), BBO (Brazilian Bibliography of Dentistry), CEPS (Chinese Electronic Periodical Services),

Sally Walker

2010-01-01

412

Use of autologous fat grafting for reconstruction postmastectomy and breast conserving surgery: a systematic review protocol  

PubMed Central

Introduction There is growing interest in the potential use of autologous fat grafting (AFG) for the purposes of breast reconstruction. However, concerns have been raised regarding the technique's clinical effectiveness, safety and interference with screening mammography. The objective of this systematic review was to determine the oncological, clinical, aesthetic and functional, patient reported, process and radiological outcomes for AFG. Methods and analysis All original studies, including randomised controlled trials, cohorts studies, case–control studies, case series and case reports involving women undergoing breast reconstruction. All AFG techniques performed for the purposes of reconstruction in the postmastectomy or breast conserving surgery setting will be considered. Outcomes are defined within this protocol along; oncological, clinical, aesthetic and functional, patient reported, process and radiological domains. The search strategy has been devised to find papers about ‘fat grafting and breast reconstruction’ and is outlined within the body of this protocol. The full search strategy is outlined within the body of the protocol. The following electronic databases will be searched from 1 January 1986 to 6 June 2013: PubMed, MEDLINE, EMBASE, SCOPUS, CINAHL, PsycINFO, SciELO, The Cochrane Library, including the Cochrane Database of Systematic Reviews (CDSR), Cochrane Central Register of Controlled Trials (CENTRAL), Database of Abstracts of Reviews of Effect (DARE), the Cochrane Methodology Register, Health Technology Assessment Database, the NHS Economic Evaluation Databases and Cochrane Groups, ClinicalTrials.gov, Current Controlled Trials Database, the World Health Organisation (WHO) International Clinical Trials Registry Platform, UpToDate.com, NHS Evidence and the York Centre for Reviews and Dissemination. Grey literature searches will also be conducted as detailed in our review protocol. Eligibility assessment occurred in two stages, title and abstract screening and then full text assessment. Data were extracted and stored in a database with standardised extraction fields to facilitate easy and consistent data entry. Ethics and dissemination This systematic review will be published in a peer-reviewed journal. It will also be presented at national and international conferences in the fields of plastic, reconstructive and aesthetic surgery and at more general surgical and methodological conferences. It will be disseminated electronically and in print. Brief reports of the review findings will be disseminated directly to the appropriate audiences of surgeons and societies through email and other modes of communication. Updates of the review will be conducted to inform and guide healthcare practice and policy. Protocol Registration PROSPERO—National Institute of Health Research (NIHR) Prospective Register of Systematic Reviews (CRD42013005254)

Agha, Riaz A; Goodacre, Tim; Orgill, Dennis P

2013-01-01

413

Prioritizing PubMed articles for the Comparative Toxicogenomic Database utilizing semantic information.  

PubMed

The Comparative Toxicogenomics Database (CTD) contains manually curated literature that describes chemical-gene interactions, chemical-disease relationships and gene-disease relationships. Finding articles containing this information is the first and an important step to assist manual curation efficiency. However, the complex nature of named entities and their relationships make it challenging to choose relevant articles. In this article, we introduce a machine learning framework for prioritizing CTD-relevant articles based on our prior system for the protein-protein interaction article classification task in BioCreative III. To address new challenges in the CTD task, we explore a new entity identification method for genes, chemicals and diseases. In addition, latent topics are analyzed and used as a feature type to overcome the small size of the training set. Applied to the BioCreative 2012 Triage dataset, our method achieved 0.8030 mean average precision (MAP) in the official runs, resulting in the top MAP system among participants. Integrated with PubTator, a Web interface for annotating biomedical literature, the proposed system also received a positive review from the CTD curation team. PMID:23160415

Kim, Sun; Kim, Won; Wei, Chih-Hsuan; Lu, Zhiyong; Wilbur, W John

2012-11-17

414

Mentoring programs for medical students - a review of the PubMed literature 2000 - 2008  

Microsoft Academic Search

BACKGROUND: Although mentoring is acknowledged as a key to successful and satisfying careers in medicine, formal mentoring programs for medical students are lacking in most countries. Within the framework of planning a mentoring program for medical students at Zurich University, an investigation was carried out into what types of programs exist, what the objectives pursued by such programs are, and

Esther Frei; Martina Stamm; Barbara Buddeberg-Fischer

2010-01-01

415

Prioritizing PubMed articles for the Comparative Toxicogenomic Database utilizing semantic information  

PubMed Central

The Comparative Toxicogenomics Database (CTD) contains manually curated literature that describes chemical–gene interactions, chemical–disease relationships and gene–disease relationships. Finding articles containing this information is the first and an important step to assist manual curation efficiency. However, the complex nature of named entities and their relationships make it challenging to choose relevant articles. In this article, we introduce a machine learning framework for prioritizing CTD-relevant articles based on our prior system for the protein–protein interaction article classification task in BioCreative III. To address new challenges in the CTD task, we explore a new entity identification method for genes, chemicals and diseases. In addition, latent topics are analyzed and used as a feature type to overcome the small size of the training set. Applied to the BioCreative 2012 Triage dataset, our method achieved 0.8030 mean average precision (MAP) in the official runs, resulting in the top MAP system among participants. Integrated with PubTator, a Web interface for annotating biomedical literature, the proposed system also received a positive review from the CTD curation team.

Wilbur, W. John

2012-01-01

416

Biomedicine's Electronic Publishing Paradigm Shift : Copyright Policy and PubMed Central  

Microsoft Academic Search

Biomedical publishing stands at a crossroads. The traditional print, peer-reviewed, subscription journal has served science well but is now being called into question. Because of spiraling print journal costs and the worldwide acceptance of the Internet as a valid publication medium, there is a compelling opportunity to re-examine our current paradigm and future options. This report illustrates the conflicts and

Barry P Markovitz

2000-01-01

417

Halloween and Food Allergies: MedlinePlus Health News Video  

MedlinePLUS

... the lower right-hand corner of the player. Halloween and Food Allergies HealthDay October 18, 2013 Related ... Children's Health Food Allergy Transcript If there's a Halloween party in your future, we don't want ...

418

Medical Research | NIH MedlinePlus the Magazine  

MedlinePLUS

... Issues / Spring 2012 Table of Contents Newspapers, radio, television, and the Internet are full of health news ... about a new result of medical research on television or read about it in the paper. Perhaps ...

419

A systematic medline analysis of therapeutic approaches in ankylosing spondylitis  

Microsoft Academic Search

Ankylosing spondylitis (AS) is a chronic inflammatory disorder involving the sacroiliac joints (SIJs), spine and less frequently\\u000a the peripheral joints. Traditionally, it is well recognised that AS is a challenging disease to manage due to the lack of\\u000a effective therapeutic options. Current evidence would suggest this has changed and there are now a number of therapies available\\u000a that provide persistent

L. Goh; A. Samanta

2009-01-01

420

Build Up Your Bones! | NIH MedlinePlus the Magazine  

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... best exercise for your bones is the weight-bearing kind, which forces you to work against gravity. Some examples of weight-bearing exercises include weight training, walking, hiking, jogging, climbing ...

421

NIH Research | NIH MedlinePlus the Magazine  

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... of this page please turn Javascript on. Feature: Memory & Forgetfulness NIH Research Summer 2013 Table of Contents ... agency for research on Alzheimer's disease and related memory research. An analysis funded by the NIA finds ...

422

Bone Marrow Diseases - Multiple Languages: MedlinePlus  

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... enable JavaScript. Bone Marrow Diseases - Multiple Languages French (français) Japanese (???) Korean (???) Russian (???????) Somali (af Soomaali) Spanish (español) Ukrainian (??????????) French (français) Bone Marrow Biopsy Biopsie de moelle osseuse - français ( ...

423

Bile Duct Diseases - Multiple Languages: MedlinePlus  

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... enable JavaScript. Bile Duct Diseases - Multiple Languages French (français) Japanese (???) Korean (???) Russian (???????) Somali (af Soomaali) Spanish (español) Ukrainian (??????????) French (français) ERCP (Endoscopic Retrograde Cholangiopancreatography) CPRE (Cholangio-pancréatographie rétrograde ...

424

Biodefense and Bioterrorism - Multiple Languages: MedlinePlus  

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425

Gout: Personal Stories | NIH MedlinePlus the Magazine  

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... please turn Javascript on. Feature: Detecting and Treating Gout Gout: Personal Stories Past Issues / Winter 2012 Table of ... Jay Hobby Jay Hobby’s Tips for Taking on Gout Somewhere high over the Atlantic on a flight ...

426

Health Information in Multiple Languages: MedlinePlus  

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... kajin Majöl) Nepali (??????) Oromo (Afaan Oromo) Polish (polski) Portuguese (português) Punjabi (??????) Romanian (Român?) ... Privacy Accessibility Quality Guidelines Viewers & Players U.S. National Library of Medicine 8600 Rockville Pike, Bethesda, MD 20894 ...

427

Research Paper: Automatically Identifying Health Outcome Information in MEDLINE Records  

Microsoft Academic Search

ObjectiveUnderstanding the effect of a given intervention on the patient's health outcome is one of the key elements in providing optimal patient care. This study presents a methodology for automatic identification of outcomes-related information in medical text and evaluates its potential in satisfying clinical information needs related to health care outcomes.DesignAn annotation scheme based on an evidence-based medicine model for

Dina Demner-Fushman; Barbara Few; Susan E. Hauser; George R. Thoma

2006-01-01

428

Preventing Falls | NIH MedlinePlus the Magazine  

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... of this page please turn Javascript on. Feature: Osteoporosis Preventing Falls Past Issues / Winter 2011 Table of ... next to your bed Free NIH Videos About Osteoporosis The NIHSeniorHealth Web site features five brief, informative ...

429

NIH Quickfinder and NIH MedlinePlus Advisory Group  

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... Other Communications Disorders Ann London , National Institute of Allergy and Infectious Diseases Richard E. Manrow, Ph.D. , National Cancer Institute John McGrath, Ph.D. , National Institute of Child Health and Human Development Gregory Roa , National Institute of Alcohol Abuse and ...

430

Diagnosing Sleep Disorders | NIH MedlinePlus the Magazine  

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... Javascript on. Feature: Are You Sleep-Deprived? Diagnosing Sleep Disorders Past Issues / Summer 2012 Table of Contents At ... several possible tests when trying to diagnose a sleep disorder: Sleep history and sleep log. If you believe ...

431

Health Information in Romanian (Român?): MedlinePlus  

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... page, please enable JavaScript. Health Information in Romanian (Român?) C Childhood Immunization Haemophilus Influenzae Type b (Hib) Vaccine - English Haemophilus Influenzae Vaccinul Tip B (Hib) - Român? (Romanian) PDF Immunization Action Coalition; Centers for Disease ...

432

Gout: Symptoms, Diagnosis & Treament | NIH MedlinePlus the Magazine  

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... the levels of uric acid in your blood. Maintain a healthy weight and exercise regularly. If you are overweight, avoid low-carbohydrate diets designed for quick loss. When you don’t eat enough carbohydrates, your body can’t completely burn its own fat. The ...

433

"Be Sickle Smart!" | NIH MedlinePlus the Magazine  

MedlinePLUS

Skip Navigation Bar Home Current Issue Past Issues For an enhanced version of this page please turn Javascript on. Special Section: Sickle Cell Disease "Be Sickle Smart! " Past Issues / Winter 2011 Table of Contents Singing star and former American Idol winner Ruben Studdard wrote the song," ...

434

Health Lines | NIH MedlinePlus the Magazine  

MedlinePLUS

... NINDS) provided primary funding for the study. Cell Phones and Your Brain Scientists have found that our ... are sensitive to the electromagnetic radiation from cell phone antennae. But it’s too early to say what ...

435

Clinical Research Trials | NIH MedlinePlus the Magazine  

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... version of this page please turn Javascript on. Clinical Research Trials Past Issues / Summer 2012 Table of Contents ... Join A Clinical Study Find You How does clinical research work? Visit our website and click on New ...

436

Health Information in Burmese (myanmasa): MedlinePlus  

MedlinePLUS

... Part 1) - English myanmasa (Burmese) Multimedia Healthy Roads Media Feeding Children the Right Message (Part 2) - English myanmasa (Burmese) Multimedia ... Part 1) - English myanmasa (Burmese) Multimedia Healthy Roads Media Feeding Children the Right Message (Part 2) - English myanmasa (Burmese) Multimedia ...

437

HIV/AIDS and Pregnancy - Multiple Languages: MedlinePlus  

MedlinePLUS

... English ?????? (Nepali) Multimedia Healthy Roads Media Somali (af Soomaali) Pregnancy and HIV Uurka iyo HIVga - af Soomaali (Somali) Bilingual PDF Health Information Translations Return to top ...

438

Foot Injuries and Disorders - Multiple Languages: MedlinePlus  

MedlinePLUS

... Multiple Languages Arabic (???????) Spanish (español) Arabic (???????) Clubfoot Overview English (Arabic) ????? ??????? ??????? - ??????? Multimedia Patient Education Institute Treating Clubfoot with the Ponseti Method English (Arabic) ???????? ????? ...

439

Benchmarking the clinical prosthetic dental literature on MEDLINE  

Microsoft Academic Search

Statement of Problem. The utility of evidence-based clinical prosthetic dental decision making is, in part, predicated on the availability of high-quality clinical trials and the use of current best evidence. With literature or outcomes continually evolving, it is difficult to know how much information is available, how fast it changes, or where it is located. Purpose. This study identified and

Kenichi Nishimura; Faheem Rasool; Michael B. Ferguson; Morton Sobel; Richard Niederman

2002-01-01

440

HealthLines | NIH MedlinePlus the Magazine  

MedlinePLUS

... 8-to-19 months. Researchers found the drug hydroxyurea reduced pain and improved key blood measurements in ... sickle cell disease as early as possible on hydroxyurea,” says Susan B. Shurin, M.D., acting director ...

441

Opioids and Chronic Pain | NIH MedlinePlus the Magazine  

MedlinePLUS

... when abused. When used properly, opioids such as morphine have long been known to help the severe ... the suffering of people with advanced cancer. Recently, morphine and similar drugs have been used to treat ...

442

A systematic MEDLINE analysis of therapeutic approaches in ankylosing spondylitis.  

PubMed

Ankylosing spondylitis (AS) is a chronic inflammatory disorder involving the sacroiliac joints (SIJs), spine and less frequently the peripheral joints. Traditionally, it is well recognised that AS is a challenging disease to manage due to the lack of effective therapeutic options. Current evidence would suggest this has changed and there are now a number of therapies available that provide persistent control of inflammatory symptoms with improvement in daily function. NSAIDs remain the first step in patient treatment. Sulphasalazine may be effective in peripheral arthritis and there are emerging data to support its use in early inflammatory back pain. Studies have shown that pamidronate and steroid injection into SIJ have a symptom-modifying effect in AS. Current data suggest that anti-TNF treatment promises early benefit which is likely to continue in the longer term. Treatment with biologics should be considered sooner rather than later in the management of AS. PMID:19562344

Goh, L; Samanta, A

2009-06-28

443

Seniors and Chronic Pain | NIH MedlinePlus the Magazine  

MedlinePLUS

... it will lead to expensive tests or more medications. And there can be conditions, such as vision or hearing loss or dementia that can limit communication about pain. To help overcome these barriers, treatment ...

444

Understanding Memory Loss | NIH MedlinePlus the Magazine  

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... please turn Javascript on. Feature: Memory & Forgetfulness Understanding Memory Loss Summer 2013 Table of Contents We've all forgotten a name, our keys, or if we locked the front door. It's only normal…once in a while. However, forgetting how to make change, use the telephone, or ...

445

HealthLines | NIH MedlinePlus the Magazine  

MedlinePLUS

... to experience depression than the kids doing the bullying. Cyberbullies harass their victims with written messages sent ... helplessness. Previous studies looked at traditional forms of bullying that include physical violence or verbal taunts. In ...

446

Health Information in Somali (af Soomaali): MedlinePlus  

MedlinePLUS

... Somali) Bilingual PDF Health Information Translations PFT (Pulmonary Function Test) Baaritaanka Shaqada Sanbabada (PFT) - af Soomaali (Somali) ... Somali) Multimedia Healthy Roads Media Pain Relievers PCA (Patient Controlled Analgesia) Pump Daawada Xanuunka ee Bukaanku Xakameeyo ( ...

447

Detecting and Treating Gout | NIH MedlinePlus the Magazine  

MedlinePLUS

... acid, a bodily waste, deposits as needle-like crystals in your joints. The crystals cause swelling, redness, heat, pain, and stiffness. In ... joints and rims of the ear. Uric acid crystals also can cause kidney stones. Look Out for ...

448

Multiple Sclerosis, Personal Stories | NIH MedlinePlus the Magazine  

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... of this page please turn Javascript on. Feature: Multiple Sclerosis Personal Stories: Nicole Lemelle, Iris Young, Michael Anthony, ... something quite different for a person living with multiple sclerosis, such as his girlfriend's brother, Chuy. The more ...

449

Latest NIH Research | NIH MedlinePlus the Magazine  

MedlinePLUS

... susceptibility to adverse health effects, and signal whether smoking cessation medications will help. This research someday may lead to better nicotine addiction treatment. Large smoking cessation trials suggest that women may have more difficulty ...

450

Exercise & Sleep | NIH MedlinePlus the Magazine  

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... on. Feature: Back to School, the Healthy Way Exercise & Sleep Past Issues / Fall 2012 Table of Contents ... helps kids. Photo: iStock 6 "Bests" About Kids' Exercise At least one hour of physical activity a ...

451

Exercise and Physical Fitness - Multiple Languages: MedlinePlus  

MedlinePLUS

... Japanese (???) Khmer (Khmer) Oromo (Afaan Oromo) Portuguese (português) Russian (???????) Somali (af Soomaali) Spanish (español) Tagalog ( ... PDF Harborview Medical Center Return to top Portuguese (português) Starting an Exercise Program Início de um programa ...

452

Blood Transfusion and Donation - Multiple Languages: MedlinePlus  

MedlinePLUS

... Hindi (??????) Japanese (???) Korean (???) Portuguese (português) Russian (???????) Somali (af Soomaali) Spanish (español) Tagalog ( ... PDF Health Information Translations Return to top Portuguese (português) Receiving Blood Transfusions Transfusões de sangue - português (Portuguese) ...

453

Common Infant and Newborn Problems - Multiple Languages: MedlinePlus  

MedlinePLUS

... Hindi (??????) Japanese (???) Korean (???) Portuguese (português) Russian (???????) Somali (af Soomaali) Spanish (español) Vietnamese ( ... PDF Health Information Translations Return to top Portuguese (português) When Should I Call My Baby's Doctor? Quando ...

454

Hearing Problems in Children - Multiple Languages: MedlinePlus  

MedlinePLUS

... Japanese (???) Korean (???) Marshallese (kajin Majöl) Portuguese (português) Russian (???????) Somali (af Soomaali) Spanish (español) Ukrainian ( ... PDF Health Information Translations Return to top Portuguese (português) Hearing Test for Your Baby Teste de audição ...

455

COPD (Chronic Obstructive Pulmonary Disease) - Multiple Languages: MedlinePlus  

MedlinePLUS

... Hindi (??????) Japanese (???) Korean (???) Portuguese (português) Russian (???????) Somali (af Soomaali) Spanish (español) Tagalog ( ... PDF Health Information Translations Return to top Portuguese (português) Chronic Obstructive Pulmonary Disease (COPD) Doença Pulmonar Obstrutiva ...

456

Keep the Beat Recipes | NIH MedlinePlus the Magazine  

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... Cup celery, rinsed and diced 1 Cup pearl onions, raw or frozen 3 Cup low-sodium chicken ... 5 minutes. Add leeks, potatoes, celery, and pearl onions, and continue to cook until the vegetables become ...

457

Safely Managing Chronic Pain | NIH MedlinePlus the Magazine  

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... and memory loss because of the injury. Melanie Griffith —A skiing accident was followed by three knee ... support of husband Antonio Banderas and her family, Griffith has improved. Montel Williams —A decade of misdiagnoses ...

458

From The Director | NIH MedlinePlus the Magazine  

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... miss is his weekly volleyball game with other employees of the NIH. Biking, weight training, and volleyball ... other lifestyle factors may prevent disease and promote wellness. Dr. ... Diabetes Prevention Program trial, which found the combination of increased physical ...

459

Transforming Discovery into Health | NIH MedlinePlus the Magazine  

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... genetic profile of each patient's cancer. Breast Cancer Success Among the early success stories in this area is the drug trastuzumab ( ... the clinic. For many disorders, there are new opportunities for NIH to shorten and straighten the pathway ...

460

Progress for the Paralyzed | NIH MedlinePlus the Magazine  

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... this page please turn Javascript on. Feature: NIBIB Robotics Progress for the Paralyzed Past Issues / Spring 2013 ... Paralyzed —The expanding options for paralyzed individuals include: robotic arms spinal cord stimulation improved prosthetic limbs restored ...

461

HIV/AIDS - Multiple Languages: MedlinePlus  

MedlinePLUS

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462

Cancer--Living with Cancer - Multiple Languages: MedlinePlus  

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... Arabic (???????) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) ... Bilingual PDF Health Information Translations Return to top French (français) Cancer Related Fatigue Fatigue liée au cancer - ...

463

Diabetes Complications | NIH MedlinePlus the Magazine  

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... of this page please turn Javascript on. Feature: Diabetes Complications Learning a Healthier Way to Live Past ... it's too late. When were you diagnosed with diabetes? I was diagnosed 11 years ago, when I ...

464

Cystic Fibrosis Research | NIH MedlinePlus the Magazine  

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... turn Javascript on. Feature: Steady Advances Against Cystic Fibrosis Cystic Fibrosis Research Past Issues / Fall 2012 Table of Contents "Remarkable strides in cystic fibrosis research over the past two decades have culminated ...

465

Mother's Milk Sharing: MedlinePlus Health News Video  

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... And three of the samples bought online were contaminated with Salmonella. The researchers blame poor collection, storage or shipping practices for the excessive bacterial growth and strongly caution against buying from online milk-sharing sites. They say that bad bacteria could impact babies, ...

466

Health Information in Chinese - Simplified (????): MedlinePlus  

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... Bilingual Chinese Community Health Resource Center Low Fat, Low Cholesterol Diet - English ????????? - ???? (Chinese - Simplified) PDF Chinese Community ... Chinese Community Health Resource Center Diets Low Fat, Low Cholesterol Diet - English ????????? - ???? (Chinese - Simplified) PDF Chinese Community ...

467

Health Information in Chinese - Traditional (????): MedlinePlus  

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468

Health Information in Italian (italiano): MedlinePlus  

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... page, please enable JavaScript. Health Information in Italian (italiano) A Alzheimer's Disease Inside the Brain: An Interactive Tour - English Dentro il cervello: un viaggio interattivo - italiano (Italian) Alzheimer's Association M Metabolic Disorders Overview of ...

469

Ask Your Pharmacist | NIH MedlinePlus the Magazine  

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... drug, ask your healthcare provider if that's a choice. Not all drugs are available in the generic form, and there might be medical reasons your doctor prefers the brand name medicine. What About Over-The-Counter Medicines? ...

470

Children's Dental Health | NIH MedlinePlus the Magazine  

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... it has a dental sealant program. Community Water Fluoridation Nearly all naturally occurring water sources contain fluoride— ... decay and even reverses early decay. Community water fluoridation adjusts the amount of fluoride in an area's ...

471

Diabetes Complications | NIH MedlinePlus the Magazine  

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... with recipes that include fruits and vegetables, fish, lean meats, chicken or turkey without the skin, dried ... and fruit, one quarter of the plate a lean protein food, and one quarter of the plate ...

472

Health Information in Tagalog (Tagalog): MedlinePlus  

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473

Stroke Stories | NIH MedlinePlus the Magazine  

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... of this page please turn Javascript on. Feature: Stroke Rehabilitation Stroke Stories Past Issues / Spring 2013 Table of Contents ... these well-known personalities suffered one or more strokes. In each case, he or she has returned ...

474

Progress Against Prostate Cancer | NIH MedlinePlus the Magazine  

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... of this page please turn Javascript on. Feature: Prostate Cancer Progress Against Prostate Cancer Past Issues / Winter 2010 Table of Contents Click to enlarge. Illustration: NIDDK What Is the Prostate? The prostate is a walnut-sized gland that ...

475

Allergy Diagnosis and Treatment | NIH MedlinePlus the Magazine  

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476

Menopause Treatments | NIH MedlinePlus the Magazine  

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477

Breaking Bad Habits | NIH MedlinePlus the Magazine  

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... potentially harmfulroutines, such as overeating, smoking, drug or alcohol abuse, gambling and even compulsive use of computers and social media. Dr. Russell Poldrack, a neurobiologist at the University ...

478

Cracking the Genetic Code | NIH MedlinePlus the Magazine  

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... this page please turn Javascript on. Cracking the Genetic Code, From NIH Director Dr. Francis S. Collins Past Issues / ... moment in science in 2000: Cracking of the genetic code raised the prospect of pinpointing the root causes ...

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HealthLines | NIH MedlinePlus the Magazine  

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... Lines Past Issues / Winter 2012 Table of Contents Social Media May Help Spot a Problem Drinker College students who write about getting drunk and blacking out on Facebook and other social networking sites are more likely to have a ...

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Infant and Newborn Nutrition - Multiple Languages: MedlinePlus  

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... Japanese (???) Korean (???) Nepali (??????) Portuguese (português) Russian (???????) Somali (af Soomaali) Spanish (español) Vietnamese ( ... Multimedia Healthy Roads Media Return to top Portuguese (português) Bottle Feeding Your Baby Alimentação do bebê com ...

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Motor Vehicle Safety - Multiple Languages: MedlinePlus  

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... Japanese (???) Korean (???) Marshallese (kajin Majöl) Portuguese (português) Russian (???????) Somali (af Soomaali) Spanish (español) Ukrainian ( ... PDF Health Information Translations Return to top Portuguese (português) Safety with Car Seats and Booster Seats Segurança ...

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Hip Injuries and Disorders - Multiple Languages: MedlinePlus  

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... Hindi (??????) Japanese (???) Korean (???) Portuguese (português) Russian (???????) Somali (af Soomaali) Spanish (español) Vietnamese ( ... PDF Health Information Translations Return to top Portuguese (português) Pelvic Fracture Fratura pélvica - português (Portuguese) Bilingual PDF ...

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Diabetes and Pregnancy - Multiple Languages: MedlinePlus  

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... Chinese - Simplified) PDF Chinese Community Health Resource Center Sample Meal Plan for Gestational Diabetic Mothers English ????????? - ???? (Chinese - ... Chinese - Traditional) PDF Chinese Community Health Resource Center Sample Meal Plan for ... Diabetics English ????????? - ???? (Chinese - Traditional) ...

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Pregnancy and Nutrition - Multiple Languages: MedlinePlus  

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... Chinese - Simplified) PDF Chinese Community Health Resource Center Sample Meal Plan for Gestational Diabetic Mothers English ????????? - ???? (Chinese - ... Chinese - Traditional) PDF Chinese Community Health Resource Center Sample Meal Plan for ... Diabetics English ????????? - ???? (Chinese - Traditional) ...

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Understanding the Healing Totem | NIH MedlinePlus the Magazine  

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... that provide natural healing medicines. Nature is the first source of cures for human ailments. The top of the totem pole depicts the Algonquin story of the Medicine Woman in the Moon. The moon is the protector and guardian of ...

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Talking With Your Doctor - Multiple Languages: MedlinePlus  

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... ??????????) Vietnamese (Tiê?ng Viê?t) Arabic (???????) Be Our Partner for Safe Health Care (Arabic) ?? ?????? ?? ????? ... Information Translations ASL (American Sign Language) Be Our Partner for Better Health Care American Sign Language (ASL) Bilingual ...

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Weight Loss Surgery - Multiple Languages: MedlinePlus  

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... Multiple Languages Arabic (???????) Spanish (español) Arabic (???????) Gastric Bypass English (Arabic) ????? ????? ?????? ?? ??????? ??????? - ??????? Multimedia Patient Education Institute Spanish (español) Cirugías para la obesidad Date ...

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FNLM Medical Awards | NIH MedlinePlus the Magazine  

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... and Mehmet Oz helped improve patient education and health literacy in their bestselling YOU: The Owner’s Manual , which sparked a series of associated books from the two doctors. Award winner Dr. Michael Roizen ... Spencer Help Out for Health: Be a Friend You can be part of ...

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High Blood Pressure in Pregnancy - Multiple Languages: MedlinePlus  

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... trudno?i - Bosanski (Bosnian) Bilingual PDF Health Information Translations Chinese - Simplified (????) High Blood Pressure in Pregnancy ????? - ???? (Chinese - Simplified) Bilingual PDF Health Information ...

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Traumatic Brain Injury - Multiple Languages: MedlinePlus  

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... enable JavaScript. Traumatic Brain Injury - Multiple Languages French (français) Japanese (???) Korean (???) Russian (???????) Somali (af Soomaali) Spanish (español) Ukrainian (??????????) French (français) Brain Scan Scintigraphie cérébrale - français (French) Bilingual PDF ...

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Germs and Hygiene - Multiple Languages: MedlinePlus  

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... Language) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Hmong (Hmoob) Japanese (???) Khmer ( ... PDF Health Information Translations Return to top French (français) Cover Your Cough English Couvrez votre bouche lorsque ...

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Carbon Monoxide Poisoning - Multiple Languages: MedlinePlus  

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... Amharic (amarunya) Arabic (???????) Chinese - Traditional (????) French (français) German (Deutsch) Haitian Creole (Kreyol) Hmong (Hmoob) Khmer ( ... Disease Control and Prevention Return to top French (français) Carbon Monoxide Poisoning English Fiche d'information sur ...

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Urinary Tract Infections - Multiple Languages: MedlinePlus  

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... ???????) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian ( ... PDF Health Information Translations Return to top French (français) Urine Sample -- Female (Clean Catch) Prélèvement ?urine chez ...

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Sprains and Strains - Multiple Languages: MedlinePlus  

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... Multiple Languages Arabic (???????) Chinese - Traditional (????) French (français) Japanese (???) Korean (???) Russian (???????) Somali (af ... of Arthritis and Musculoskeletal and Skin Diseases French (français) Ankle Sprain Entorse de la cheville - français (French) ...

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Laser Eye Surgery - Multiple Languages: MedlinePlus  

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... sharing features on this page, please enable JavaScript. Laser Eye Surgery - Multiple Languages Arabic (???????) Spanish (español) Arabic (???????) LASIK English (Arabic) ??????? ???????? ????? - ????? ???????? - ??????? ...

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Creating an Online Dictionary of Abbreviations from MEDLINE  

Microsoft Academic Search

The immense volume and rapid growth of the biomedical literature present specialchallenges for both human readers and automatic algorithms. One such challenge derives fromthe common and uncontrolled use of abbreviations in the literature. Each additional abbreviationincreases the effective size of the vocabulary for a field. To create an automatically generatedand maintained lexicon of abbreviations, we have developed an algorithm to

Jeffrey T. Chang; Hinrich Schütze

2002-01-01

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MEDLINE Abstracts Classification Based on Noun Phrases Extraction  

NASA Astrophysics Data System (ADS)

Many algorithms have come up in the last years to tackle automated text categorization. They have been exhaustively studied, leading to several variants and combinations not only in the particular procedures but also in the treatment of the input data. A widely used approach is representing documents as Bag-Of-Words (BOW) and weighting tokens with the TFIDF schema. Many researchers have thrown into precision and recall improvements and classification time reduction enriching BOW with stemming, n-grams, feature selection, noun phrases, metadata, weight normalization, etc. We contribute to this field with a novel combination of these techniques. For evaluation purposes, we provide comparisons to previous works with SVM against the simple BOW. The well known OHSUMED corpus is exploited and different sets of categories are selected, as previously done in the literature. The conclusion is that the proposed method can be successfully applied to existing binary classifiers such as SVM outperforming the mixture of BOW and TFIDF approaches.

Ruiz-Rico, Fernando; Vicedo, José-Luis; Rubio-Sánchez, María-Consuelo

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Keep Gum Disease Away! | NIH MedlinePlus the Magazine  

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... this page please turn Javascript on. Feature: Fighting Gum Disease Keep Gum Disease Away! Past Issues / Fall 2010 Table of ... repair damage resulting from uncared-for teeth and gums. Photo: Frederic Havens "Take care of your teeth, ...

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Get Your Flu Shot!| NIH MedlinePlus the Magazine  

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... or lung disease "For the 2010–2011 flu season, the flu vaccine provides protection against the 2009 ... seasonal flu vaccines. For the 2010-2011 flu season, the flu vaccine provides protection against the 2009 ...

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End of Life Issues - Multiple Languages: MedlinePlus  

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... Chinese - Simplified (????) End-of-Life Choices: CPR & DNR English ???????: ????????? - ???? (Chinese - Simplified) PDF Family ... Chinese - Traditional (????) End-of-Life Choices: CPR & DNR English ?????????????????? - ???? (Chinese - Traditional) PDF Family ...