Sample records for pubmed medline cochrane

  1. Searching the MEDLINE Literature Database through PubMed: A Short Guide

    Microsoft Academic Search

    Edith Motschall; Yngve Falck-Ytter

    2005-01-01

    The Medline database from the National Library of Medicine (NLM) contains more than 12 million bibliographic citations from over 4,600 international biomedical journals. One of the interfaces for searching Medline is PubMed, provided by the NLM for free access via the Internet (www.pubmed.gov). Also searchable with the PubMed interface are non-Medline citations, i.e. articles supplied by publishers to the NLM.

  2. All Information Is Not Equal: Using the Literature Databases PubMed and The Cochrane Library for Identifying the Evidence on Granulocyte Transfusion Therapy.

    PubMed

    Metzendorf, Maria-Inti; Schulz, Manuela; Braun, Volker

    2014-10-01

    To be able to take well-informed decisions or carry out sound research, clinicians and researchers alike require specific information seeking skills matching their respective information needs. Biomedical information is traditionally available via different literature databases. This article gives an introduction to two diverging sources, PubMed (23 million references) and The Cochrane Library (800,000 references), both of which offer sophisticated instruments for searching an increasing amount of medical publications of varied quality and ambition. Whereas PubMed as an unfiltered source of primary literature comprises all different kinds of publication types occurring in academic journals, The Cochrane Library is a pre-filtered source which offers access to either synthesized publication types or critically appraised and carefully selected references. A search approach has to be carried out deliberately and requires a good knowledge on the scope and features of the databases as well as on the ability to build a search strategy in a structured way. We present a specific and a sensitive search approach, making use of both databases within two application case scenarios in order to identify the evidence on granulocyte transfusions for infections in adult patients with neutropenia. PMID:25538539

  3. NCBI: PubMed

    NSDL National Science Digital Library

    NCBI (National Center for Biotechnology Information)

    2012-01-20

    PubMed comprises more than 21 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.

  4. Identifying nurse staffing research in Medline: development and testing of empirically derived search strategies with the PubMed interface

    Microsoft Academic Search

    Michael Simon; Elke Hausner; Susan F Klaus; Nancy E Dunton

    2010-01-01

    BACKGROUND: The identification of health services research in databases such as PubMed\\/Medline is a cumbersome task. This task becomes even more difficult if the field of interest involves the use of diverse methods and data sources, as is the case with nurse staffing research. This type of research investigates the association between nurse staffing parameters and nursing and patient outcomes.

  5. PUBMED OR NLM GATEWAY

    EPA Science Inventory

    PubMed, a service of the National Library of Medicine, provides access to over 12 million MEDLINE citations back to the mid-1960's and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. PubMed was design...

  6. PubMed

    NSDL National Science Digital Library

    National Library of Medicine

    This site, hosted by PubMed, is a service of the National Library of Medicine. The searchable site includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources.

  7. PubMed contains all of MEDLINE (1966-present), OLDMEDLINE (1946-1965), PubMed in-process records (new citations not yet fully indexed) and some additional non-MEDLINE citations. It is the primary database for researchers in the fields of biochemistry, mol

    E-print Network

    California at Berkeley, University of

    BASIC SEARCH TECHNIQUES PubMed searching is easy. Just enter your search terms in the search box to additional searching options. Keyword Searching Enter one or more keywords (e.g., molecular motors) in the search box and click Search. PubMed automatically combines (ANDs) significant terms together using

  8. Search Pubmed - Geographic Information Systems & Science

    Cancer.gov

    PubMed, a service of the National Center for Biotechnology Information (NCBI) of the National Library of Medicine (NLM), provides access to MEDLINE citations for over 12 million scientific journal articles dating back to the 1960s. Searches of the PubMed databases are executed on NCBI's servers. Please read NCBI's disclaimer and copyright information before searching.

  9. http://www.ncbi.nlm.nih.gov/sites/entrez?otool=ijputmlib PubMed PubMed ---------------------------------------------------p.2

    E-print Network

    Miyashita, Yasushi

    2014.4 PubMed http://www.ncbi.nlm.nih.gov/sites/entrez?otool=ijputmlib PubMed Pub®/PubMed® Resources Guide http://www.nlm.nih.gov/bsd/pmresources.html JOURNALS List of Journals Indexed for MEDLINE List of All Journals Included in PubMed® http://www.nlm.nih.gov/bsd/serfile_addedinfo.html Pub

  10. PubMed: National Library of Medicine

    NSDL National Science Digital Library

    1997-01-01

    The US National Library of Medicine has made its searchable MEDLINE database freely available to all Americans. This site provides searchable access to over 8.5 million MEDLINE and PreMEDLINE citations. Users can also search molecular biology databases from the National Center for Biotechnology Information's Entrez system. Entrez, integrates information from a number of databases (nucleotide sequences, protein sequences, macromolecular structures, whole genomes, and MEDLINE) at the National Center for Biotechnology Information (NCBI). Entrez provides access "to over 10 million citations in MEDLINE, PreMEDLINE, and other related databases, with links to participating online journals." Its new single search interface includes four new menus that display field limits, indexes, search history (active for one hour), and a clipboard where users can store up to 500 items for one hour.A journal browser, which allows users to find articles based on the journals they appear in, and clinical alert notices are also featured at PubMed.

  11. PubMed Assistant: a biologist-friendly interface for enhanced PubMed search.

    PubMed

    Ding, Jing; Hughes, Laron M; Berleant, Daniel; Fulmer, Andy W; Wurtele, Eve Syrkin

    2006-02-01

    MEDLINE is one of the most important bibliographical information sources for biologists and medical workers. Its PubMed interface supports Boolean queries, which are potentially expressive and exact. However, PubMed is also designed to support simplicity of use at the expense of query expressiveness and exactness. Many PubMed users have never tried explicit Boolean queries. We developed a Java program, PubMed Assistant, to make literature access easier in several ways. PubMed Assistant provides an interface that efficiently displays information about the citations and includes useful functions such as keyword highlighting, export to citation managers, clickable links to Google Scholar and others that are lacking in PubMed. PMID:16332704

  12. PubMed Tutorial

    NSDL National Science Digital Library

    PubMed Tutorial is a "web-based learning program that will show you how to search PubMed, the National Library of Medicine's journal literature search system." Clear, detailed explanations and helpful animations guide users in making the most of PubMed's many features. The level of detail in this tutorial is amazing, yet not overwhelming (thanks again to animations and demonstrations that replicate the PubMed user interface). A final review section offers a number of practice exercises.

  13. Methods to improve recruitment to randomised controlled trials: Cochrane systematic review and meta-analysis

    PubMed Central

    Treweek, Shaun; Lockhart, Pauline; Pitkethly, Marie; Cook, Jonathan A; Kjeldstrøm, Monica; Johansen, Marit; Taskila, Taina K; Sullivan, Frank M; Wilson, Sue; Jackson, Catherine; Jones, Ritu; Mitchell, Elizabeth D

    2013-01-01

    This review is an abridged version of a Cochrane Review previously published in the Cochrane Database of Systematic Reviews 2010, Issue 4, Art. No.: MR000013 DOI: 10.1002/14651858.MR000013.pub5 (see www.thecochranelibrary.com for information). Cochrane Reviews are regularly updated as new evidence emerges and in response to feedback, and Cochrane Database of Systematic Reviews should be consulted for the most recent version of the review. Objective To identify interventions designed to improve recruitment to randomised controlled trials, and to quantify their effect on trial participation. Design Systematic review. Data sources The Cochrane Methodology Review Group Specialised Register in the Cochrane Library, MEDLINE, EMBASE, ERIC, Science Citation Index, Social Sciences Citation Index, C2-SPECTR, the National Research Register and PubMed. Most searches were undertaken up to 2010; no language restrictions were applied. Study selection Randomised and quasi-randomised controlled trials, including those recruiting to hypothetical studies. Studies on retention strategies, examining ways to increase questionnaire response or evaluating the use of incentives for clinicians were excluded. The study population included any potential trial participant (eg, patient, clinician and member of the public), or individual or group of individuals responsible for trial recruitment (eg, clinicians, researchers and recruitment sites). Two authors independently screened identified studies for eligibility. Results 45 trials with over 43?000 participants were included. Some interventions were effective in increasing recruitment: telephone reminders to non-respondents (risk ratio (RR) 1.66, 95% CI 1.03 to 2.46; two studies, 1058 participants), use of opt-out rather than opt-in procedures for contacting potential participants (RR 1.39, 95% CI 1.06 to 1.84; one study, 152 participants) and open designs where participants know which treatment they are receiving in the trial (RR 1.22, 95% CI 1.09 to 1.36; two studies, 4833 participants). However, the effect of many other strategies is less clear, including the use of video to provide trial information and interventions aimed at recruiters. Conclusions There are promising strategies for increasing recruitment to trials, but some methods, such as open-trial designs and opt-out strategies, must be considered carefully as their use may also present methodological or ethical challenges. Questions remain as to the applicability of results originating from hypothetical trials, including those relating to the use of monetary incentives, and there is a clear knowledge gap with regard to effective strategies aimed at recruiters. PMID:23396504

  14. MEDLINE PLUS

    EPA Science Inventory

    MEDLINE plus is the National Library of Medicine's web site for consumer health information. MEDLINE plus has extensive information from the National Institutes of Health and other trusted sources on over 600 diseases and conditions. There are also lists of hospitals and physicia...

  15. What is a Cochrane review?

    PubMed

    Cipriani, A; Furukawa, T A; Barbui, C

    2011-09-01

    Systematic reviews carried out by Cochrane Collaboration (an international network of researchers belonging to this independent, not-for-profit organization) are recognized worldwide as the highest standard in evidence-based healthcare. The main reason is that Cochrane reviews follow a common and specific methodology to limit bias and random error. In this issue, we highlight the most important methodological features of Cochrane reviews, also reporting details on the editorial process to publish the review in the Cochrane Library. PMID:21922964

  16. Home - PubMed - NCBI

    Science.gov Websites

    Manual NCBI News PubMed PubMed Central (PMC) PubMed Clinical Queries PubMed Health All Literature Resources... Proteins BioSystems BLAST (Basic Local Alignment Search Tool)...

  17. The Cochrane tobacco addiction group.

    PubMed

    Mehta, Monaz

    2013-11-01

    The Cochrane Tobacco Addiction Group produces up-to-date systematic reviews of interventions for the cessation and prevention of tobacco use. Many of our Cochrane Reviews have also been published in scientific journals. Our review prioritization schedule is informed by our group's experience and expertise as well as identifying topics for reviews via regular searches of current scientific literature and from other news sources, such as the Action on Smoking and Health updates. The Cochrane Register of Studies allows identification of new trials, which might be eligible for review updates. Everyday challenges include timely publishing and updating of our reviews, and ensuring compliance to Cochrane methodological expectations of Cochrane intervention review standards. We are grateful for the contributions of our authors and peer reviewers, with whom we aim to have close working and productive relationships. We look forward to continuing our contribution toward a reliable evidence base on interventions to combat tobacco addiction. PMID:24325412

  18. Finding Themes in Medline Documents Probabilistic Similarity Search

    E-print Network

    Shatkay, Hagit

    National Center for Biotechnology Information National Library of Medicine National Institutes of Health: 1 Medline is maintained by the National Library of Medicine, and can be searched using PubMed, http

  19. Telehealthcare for asthma: a Cochrane review

    PubMed Central

    McLean, Susannah; Chandler, David; Nurmatov, Ulugbek; Liu, Joseph; Pagliari, Claudia; Car, Josip; Sheikh, Aziz

    2011-01-01

    Background: Telehealthcare has the potential to provide care for long-term conditions that are increasingly prevalent, such as asthma. We conducted a systematic review of studies of telehealthcare interventions used for the treatment of asthma to determine whether such approaches to care are effective. Methods: We searched the Cochrane Airways Group Specialised Register of Trials, which is derived from systematic searches of bibliographic databases including CENTRAL (the Cochrane Central Register of Controlled Trials), MEDLINE, Embase, CINAHL (Cumulative Index to Nursing and Allied Health Literature) and PsycINFO, as well as other electronic resources. We also searched registers of ongoing and unpublished trials. We were interested in studies that measured the following outcomes: quality of life, number of visits to the emergency department and number of admissions to hospital. Two reviewers identified studies for inclusion in our meta-analysis. We extracted data and used fixedeffect modelling for the meta-analyses. Results: We identified 21 randomized controlled trials for inclusion in our analysis. The methods of telehealthcare intervention these studies investigated were the telephone and video- and Internet-based models of care. Meta-analysis did not show a clinically important improvement in patients’ quality of life, and there was no significant change in the number of visits to the emergency department over 12 months. There was a significant reduction in the number of patients admitted to hospital once or more over 12 months (risk ratio 0.25 [95% confidence interval 0.09 to 0.66]). Interpretation: We found no evidence of a clinically important impact on patients’ quality of life, but telehealthcare interventions do appear to have the potential to reduce the risk of admission to hospital, particularly for patients with severe asthma. Further research is required to clarify the cost-effectiveness of models of care based on telehealthcare. PMID:21746825

  20. Lida Cochran, Matriarch of Visual Literacy

    ERIC Educational Resources Information Center

    Davis, Harry

    2009-01-01

    In this article, the author describes the life and works of Lida Cochran, the matriarch of visual literacy. Lida was practicing "visual literacy" long before there was an association devoted to it. Lida has worked with the AECT, ECT Foundation (the Cochran Internship is named for her husband, Lee Cochran), and the International Visual Literacy…

  1. Pathogenicity of amoebae. - PubMed - NCBI

    Science.gov Websites

    Manual NCBI News PubMed PubMed Central (PMC) PubMed Clinical Queries PubMed Health All Literature Resources... Proteins BioSystems BLAST (Basic Local Alignment Search Tool)...

  2. Burn resuscitation. - PubMed - NCBI

    Science.gov Websites

    Manual NCBI News PubMed PubMed Central (PMC) PubMed Clinical Queries PubMed Health All Literature Resources... Proteins BioSystems BLAST (Basic Local Alignment Search Tool)...

  3. Burn wound infections. - PubMed - NCBI

    Science.gov Websites

    Manual NCBI News PubMed PubMed Central (PMC) PubMed Clinical Queries PubMed Health All Literature Resources... Proteins BioSystems BLAST (Basic Local Alignment Search Tool)...

  4. Modeling actions of PubMed users with n-gram language models

    Microsoft Academic Search

    Jimmy J. Lin; W. John Wilbur

    2009-01-01

    Transaction logs from online search engines are valuable for two reasons: First, they provide insight into human information-seeking behavior. Second, log data can be used to train user models, which can then be applied to improve retrieval systems. This article presents a study of logs from PubMed? , the public gateway to the MEDLINE? database of bibliographic records from the

  5. Making PubMed Searching Simple: Learning to Retrieve Medical Literature Through Interactive Problem Solving

    Microsoft Academic Search

    Beatriz Vincent; Maurice Vincent; Carlos Gil Ferreira

    Searching the literature has a direct, beneficial influ- ence on patient care. The amount of medical scientific information has increased to a great extent, while the development of networking technologies has broadened access to online databases. Successful searches depend upon understanding technical librarianship concepts and the skills for mastering searching interfaces. From a problem-oriented approach, concepts like MEDLINE coverage, PubMed

  6. PubMed Help PubMed comprises over 23 million citations for biomedical literature from MEDLINE, life

    E-print Network

    Levin, Judith G.

    the key concepts for your search. 2 Enter the terms (or key concepts) in the search box. 3 Suggestions by Bonnie W. Ramsey about gene therapy for cystic fibrosis enter the following search terms into the search will display as you type your search terms. Click Turn off to temporarily disable the autocomplete feature. 4

  7. Demystifying the Search Button: A Comprehensive PubMed Search Strategy for Performing an Exhaustive Literature Review.

    PubMed

    McKeever, Liam; Nguyen, Van; Peterson, Sarah J; Gomez-Perez, Sandra; Braunschweig, Carol

    2015-08-01

    A thorough review of the literature is the basis of all research and evidence-based practice. A gold-standard efficient and exhaustive search strategy is needed to ensure all relevant citations have been captured and that the search performed is reproducible. The PubMed database comprises both the MEDLINE and non-MEDLINE databases. MEDLINE-based search strategies are robust but capture only 89% of the total available citations in PubMed. The remaining 11% include the most recent and possibly relevant citations but are only searchable through less efficient techniques. An effective search strategy must employ both the MEDLINE and the non-MEDLINE portion of PubMed to ensure all studies have been identified. The robust MEDLINE search strategies are used for the MEDLINE portion of the search. Usage of the less robust strategies is then efficiently confined to search only the remaining 11% of PubMed citations that have not been indexed for MEDLINE. The current article offers step-by-step instructions for building such a search exploring methods for the discovery of medical subject heading (MeSH) terms to search MEDLINE, text-based methods for exploring the non-MEDLINE database, information on the limitations of convenience algorithms such as the "related citations feature," the strengths and pitfalls associated with commonly used filters, the proper usage of Boolean operators to organize a master search strategy, and instructions for automating that search through "MyNCBI" to receive search query updates by email as new citations become available. PMID:26129895

  8. A Systematic Review of Cochrane Anticoagulation Reviews

    PubMed Central

    Cundiff, David Keith

    2009-01-01

    Context I coauthored a published review of anticoagulation for venous thromboembolism in the Cochrane Database of Systematic Reviews and published a review on the same topic in MedGenMed (now the Medscape Journal of Medicine). In contrast to the article in Medscape, the discussion and conclusions in the Cochrane review were altered appreciably during the review process. Consequently, I decided to critique all anticoagulation drug-related reviews and protocols in the Cochrane database with feedback letters concerning any issues of potential controversy. Evidence Acquisition Using key words in the search engine of the Cochrane Reviews, I located reviews and protocols involving anticoagulant drugs. I critiqued each anticoagulation review and protocol and sent a total of 57 feedback letters to Cochrane concerning each publication to elicit a response/rebuttal from the authors. Evidence Synthesis Cochrane anticoagulation review editors acknowledged receipt of all letters. As of 12 months after receipt of my last letter, the Cochrane authors have replied to 13 of the 57 and agreed with many of my points. Two protocols were withdrawn after my feedback letters were acknowledged. The 58 Cochrane anticoagulation drug reviews, including mine, contained 9 categories of methodological errors (207 total instances) and 4 types of biases (18 total instances). This review of those Cochrane reviews suggests that the effectiveness of anticoagulants for 30 medical indications is questionable. Conclusions The efficacy of anticoagulants for treatment and prophylaxis for 30 current medical indications should be reconsidered by the scientific community and medical regulatory agencies. At least 50,000 people per year worldwide have fatal bleeding due to anticoagulant treatment or prophylaxis for these indications. PMID:19295926

  9. Alpha-glucosidase inhibitors for patients with type 2 diabetes: results from a Cochrane systematic review and meta-analysis

    Microsoft Academic Search

    FLORIS A. VAN DE LAAR; PETER L. LUCASSEN; REINIER P. AKKERMANS; ELOY H. VAN DE LISDONK; G. E. H. M. Rutten; CHRIS VAN WEEL

    2005-01-01

    OBJECTIVE: To review the effects of monotherapy with alpha-glucosidase inhibitors (AGIs) for patients with type 2 diabetes, with respect to mortality, morbidity, glycemic control, insulin levels, plasma lipids, body weight, and side effects. RESEARCH DESIGN AND METHODS: We systematically searched the Cochrane Central register of Controlled Trials, MEDLINE, EMBASE, Current Contents, LILACS, databases of ongoing trials, and reference lists, and

  10. MedlinePlus FAQ: What is MedlinePlus?

    MedlinePLUS

    ... MedlinePlus pages contain carefully selected links to Web resources with health information on over 950 topics. MedlinePlus follows a list of guidelines for the inclusion of Web sites. The MedlinePlus health topic pages ...

  11. MEDLINE (MEDLARS ONLINE)

    EPA Science Inventory

    MEDLINE (MEDlars onLINE) is the National Library of Medicines (NLM) premier bibliographic database covering the fields of medicine, nursing, dentistry, veterinary medicine, the health care system, and the preclinical sciences. It contains bibliographic citations (e.g., authors, ...

  12. MedlinePlus FAQ: What's the difference between MedlinePlus and MedlinePlus Connect?

    MedlinePLUS

    ... Question: What's the difference between MedlinePlus and MedlinePlus Connect? To use the sharing features on this page, please enable JavaScript. Answer: MedlinePlus Connect is a free service that allows electronic health ...

  13. Dialogues with Marilyn Cochran-Smith

    ERIC Educational Resources Information Center

    Fiorentini, Dario; Crecci, Vanessa Moreira

    2015-01-01

    For more than 30 years, Dr. Marilyn Cochran-Smith has developed and directed research and contributed to publications about education and "practitioner research," especially about teachers' research and learning in inquiry communities. Her primary topics are inquiry communities, teacher research, teacher education for social…

  14. MedlinePlus Connect

    MedlinePLUS

    ... Web application provide responses in different formats. The Web application returns a link to a formatted MedlinePlus Connect response page. This page will include links to information relevant to the problem/diagnosis, medication, or lab test. For a diagnosis/problem code, the response page ...

  15. PubMed, PubMed Central and PMCID's Rev. 27 April 2011

    E-print Network

    Chen, Tsuhan

    and journal editorial staff. See Data Element (Field) codes and descriptors for PubMed records http://www.nlm.nih.gov/United States R01 HD041012-09/HD/NICHD NIH HHS/United States #12;3 PMID : PCMID Converter http://www.ncbi.nlm.nih.gov. Skill Kit: PubMed Central ID and PubMed http://www.nlm.nih.gov/pubs/techbull/so08/so08_skill

  16. Health Videos: MedlinePlus

    MedlinePLUS Videos and Cool Tools

    ... navigation menu has been collapsed. Menu Health Topics Drugs & Supplements Videos & Tools About MedlinePlus Show Search Search ... MedlinePlus Site Map FAQs Contact Us Health Topics Drugs & Supplements Videos & Tools Español You Are Here: Home ? ...

  17. Medical Questions? Medline has Answers.

    ERIC Educational Resources Information Center

    Modlin, Melanie

    1998-01-01

    Developed by the National Library of Medicine (NLM), the electronic version of "Index Medicus," Medline is the world's largest collection of published medical knowledge. Discussion includes accessing Medline (cost-free) with a Web browser, librarians as links between patients and physicians; and examples of Medline searches. (AEF)

  18. Videos & Tools: MedlinePlus

    MedlinePLUS Videos and Cool Tools

    ... U.S. National Library of Medicine Menu Health Topics Drugs & Supplements Videos & Tools About MedlinePlus Search Search MedlinePlus ... MedlinePlus Site Map FAQs Contact Us Health Topics Drugs & Supplements Videos & Tools Español You Are Here: Home ? ...

  19. Meta-analysis and The Cochrane Collaboration: 20 years of the Cochrane Statistical Methods Group

    PubMed Central

    2013-01-01

    The Statistical Methods Group has played a pivotal role in The Cochrane Collaboration over the past 20 years. The Statistical Methods Group has determined the direction of statistical methods used within Cochrane reviews, developed guidance for these methods, provided training, and continued to discuss and consider new and controversial issues in meta-analysis. The contribution of Statistical Methods Group members to the meta-analysis literature has been extensive and has helped to shape the wider meta-analysis landscape. In this paper, marking the 20th anniversary of The Cochrane Collaboration, we reflect on the history of the Statistical Methods Group, beginning in 1993 with the identification of aspects of statistical synthesis for which consensus was lacking about the best approach. We highlight some landmark methodological developments that Statistical Methods Group members have contributed to in the field of meta-analysis. We discuss how the Group implements and disseminates statistical methods within The Cochrane Collaboration. Finally, we consider the importance of robust statistical methodology for Cochrane systematic reviews, note research gaps, and reflect on the challenges that the Statistical Methods Group faces in its future direction. PMID:24280020

  20. A biobehavioral perspective of tumor biology. - PubMed - NCBI

    Science.gov Websites

    Manual NCBI News PubMed PubMed Central (PMC) PubMed Clinical Queries PubMed Health All Literature Resources... Proteins BioSystems BLAST (Basic Local Alignment Search Tool)...

  1. TAP CBRN preparedness: knowledge, training and networks. - PubMed...

    Science.gov Websites

    Manual NCBI News PubMed PubMed Central (PMC) PubMed Clinical Queries PubMed Health All Literature Resources... Proteins BioSystems BLAST (Basic Local Alignment Search Tool)...

  2. Bacterial respiration of arsenic and selenium. - PubMed - NCBI

    Science.gov Websites

    Manual NCBI News PubMed PubMed Central (PMC) PubMed Clinical Queries PubMed Health All Literature Resources... Proteins BioSystems BLAST (Basic Local Alignment Search Tool)...

  3. Current management of acute cutaneous wounds. - PubMed - NCBI

    Science.gov Websites

    Manual NCBI News PubMed PubMed Central (PMC) PubMed Clinical Queries PubMed Health All Literature Resources... Proteins BioSystems BLAST (Basic Local Alignment Search Tool)...

  4. Molecular genetics of human pigmentation diversity. - PubMed...

    Science.gov Websites

    Manual NCBI News PubMed PubMed Central (PMC) PubMed Clinical Queries PubMed Health All Literature Resources... Proteins BioSystems BLAST (Basic Local Alignment Search Tool)...

  5. The cancer prevention and control research network. - PubMed...

    Science.gov Websites

    Manual NCBI News PubMed PubMed Central (PMC) PubMed Clinical Queries PubMed Health All Literature Resources... Proteins BioSystems BLAST (Basic Local Alignment Search Tool)...

  6. Law, liability, and public health emergencies. - PubMed - NCBI

    Science.gov Websites

    Manual NCBI News PubMed PubMed Central (PMC) PubMed Clinical Queries PubMed Health All Literature Resources... Proteins BioSystems BLAST (Basic Local Alignment Search Tool)...

  7. Handwashing practices and challenges in Bangladesh. - PubMed...

    Science.gov Websites

    Manual NCBI News PubMed PubMed Central (PMC) PubMed Clinical Queries PubMed Health All Literature Resources... Proteins BioSystems BLAST (Basic Local Alignment Search Tool)...

  8. Diagnosis and management of Acanthamoeba keratitis. - PubMed...

    Science.gov Websites

    Manual NCBI News PubMed PubMed Central (PMC) PubMed Clinical Queries PubMed Health All Literature Resources... Proteins BioSystems BLAST (Basic Local Alignment Search Tool)...

  9. Burn injury and explosions: an Australian perspective. - PubMed...

    Science.gov Websites

    Manual NCBI News PubMed PubMed Central (PMC) PubMed Clinical Queries PubMed Health All Literature Resources... Proteins BioSystems BLAST (Basic Local Alignment Search Tool)...

  10. Chemotherapy-induced nausea and vomiting. - PubMed - NCBI

    Science.gov Websites

    Manual NCBI News PubMed PubMed Central (PMC) PubMed Clinical Queries PubMed Health All Literature Resources... Proteins BioSystems BLAST (Basic Local Alignment Search Tool)...

  11. Melanoma surveillance in the United States. - PubMed - NCBI

    Science.gov Websites

    Manual NCBI News PubMed PubMed Central (PMC) PubMed Clinical Queries PubMed Health All Literature Resources... Proteins BioSystems BLAST (Basic Local Alignment Search Tool)...

  12. Soil erosion: data say C sink. - PubMed - NCBI

    Science.gov Websites

    Manual NCBI News PubMed PubMed Central (PMC) PubMed Clinical Queries PubMed Health All Literature Resources... Proteins BioSystems BLAST (Basic Local Alignment Search Tool)...

  13. The year in burns 2008. - PubMed - NCBI

    Science.gov Websites

    Manual NCBI News PubMed PubMed Central (PMC) PubMed Clinical Queries PubMed Health All Literature Resources... Proteins BioSystems BLAST (Basic Local Alignment Search Tool)...

  14. Molecular epidemiology of cryptosporidiosis: an update. - PubMed...

    Science.gov Websites

    Manual NCBI News PubMed PubMed Central (PMC) PubMed Clinical Queries PubMed Health All Literature Resources... Proteins BioSystems BLAST (Basic Local Alignment Search Tool)...

  15. Ultraviolet emission spectra of sunbeds. - PubMed - NCBI

    Science.gov Websites

    Manual NCBI News PubMed PubMed Central (PMC) PubMed Clinical Queries PubMed Health All Literature Resources... Proteins BioSystems BLAST (Basic Local Alignment Search Tool)...

  16. Vaccines and Guillain-Barré syndrome. - PubMed - NCBI

    Science.gov Websites

    Manual NCBI News PubMed PubMed Central (PMC) PubMed Clinical Queries PubMed Health All Literature Resources... Proteins BioSystems BLAST (Basic Local Alignment Search Tool)...

  17. Impact of stress on cancer metastasis. - PubMed - NCBI

    Science.gov Websites

    Manual NCBI News PubMed PubMed Central (PMC) PubMed Clinical Queries PubMed Health All Literature Resources... Proteins BioSystems BLAST (Basic Local Alignment Search Tool)...

  18. Hand washing for preventing diarrhoea. - PubMed - NCBI

    Science.gov Websites

    Manual NCBI News PubMed PubMed Central (PMC) PubMed Clinical Queries PubMed Health All Literature Resources... Proteins BioSystems BLAST (Basic Local Alignment Search Tool)...

  19. The year in burns 2010. - PubMed - NCBI

    Science.gov Websites

    Manual NCBI News PubMed PubMed Central (PMC) PubMed Clinical Queries PubMed Health All Literature Resources... Proteins BioSystems BLAST (Basic Local Alignment Search Tool)...

  20. Consumer antibacterial soaps: effective or just risky? - PubMed...

    Science.gov Websites

    Manual NCBI News PubMed PubMed Central (PMC) PubMed Clinical Queries PubMed Health All Literature Resources... Proteins BioSystems BLAST (Basic Local Alignment Search Tool)...

  1. Cancer risk modelling and radiological protection. - PubMed ...

    Science.gov Websites

    Manual NCBI News PubMed PubMed Central (PMC) PubMed Clinical Queries PubMed Health All Literature Resources... Proteins BioSystems BLAST (Basic Local Alignment Search Tool)...

  2. Hygiene: new hopes, new horizons. - PubMed - NCBI

    Science.gov Websites

    Manual NCBI News PubMed PubMed Central (PMC) PubMed Clinical Queries PubMed Health All Literature Resources... Proteins BioSystems BLAST (Basic Local Alignment Search Tool)...

  3. Psychosocial care in cancer. - PubMed - NCBI

    Science.gov Websites

    Manual NCBI News PubMed PubMed Central (PMC) PubMed Clinical Queries PubMed Health All Literature Resources... Proteins BioSystems BLAST (Basic Local Alignment Search Tool)...

  4. Acta Informatica Medica Is Indexed In Pubmed And Archived In Pubmed Central

    PubMed Central

    Masic, Izet

    2013-01-01

    Acta Informatica Medica journal has been accepted for archiving in PubMed Central from 2011 onward. The journal started in 1993 as the official journal of the Society for Medical Informatics of Bosnia and Herzegovina. During the last 3 years, Acta Informatica Medica has een included in almost all prestigious online databases, including PubMed, Scopus and EMBASE. The 20th volume of the journal is fully international, with papers from 18 countries. PMID:23572852

  5. Studying PubMed usages in the field for complex problem solving: Implications for tool design

    PubMed Central

    Song, Jean; Tonks, Jennifer Steiner; Meng, Fan; Xuan, Weijian; Ameziane, Rafiqa

    2012-01-01

    Many recent studies on MEDLINE-based information seeking have shed light on scientists’ behaviors and associated tool innovations that may improve efficiency and effectiveness. Few if any studies, however, examine scientists’ problem-solving uses of PubMed in actual contexts of work and corresponding needs for better tool support. Addressing this gap, we conducted a field study of novice scientists (14 upper level undergraduate majors in molecular biology) as they engaged in a problem solving activity with PubMed in a laboratory setting. Findings reveal many common stages and patterns of information seeking across users as well as variations, especially variations in cognitive search styles. Based on findings, we suggest tool improvements that both confirm and qualify many results found in other recent studies. Our findings highlight the need to use results from context-rich studies to inform decisions in tool design about when to offer improved features to users. PMID:24376375

  6. Dr. Felix's Free MEDLINE Page

    NSDL National Science Digital Library

    Perry, Helga J.

    1997-01-01

    If you need to search the National Medical Library's Medline database, Dr. Felix's Free Medline Page is a good place to start. This simple page is a comparison of twenty-eight web based services that offer free access to parts or all of Medline. For each service users can access information about database coverage, registration requirements, usage restrictions, and document delivery. Hypertext links are available from all of the services discussed. Dr. Felix is a quick and convenient way to launch a Medline session that can inform users of the possible limitations of their search right from the start.

  7. Medline Plus: Sports Injuries

    NSDL National Science Digital Library

    Exercising and playing sports can lead to a sound mind and body, but sports-related injuries can be frustrating for anyone. This very helpful site, offered as part of the Medline Plus series from the U.S. National Library of Medicine, contains dozens of fact sheets, media presentations, and other items regarding various sports injuries. Visitors who know exactly what they need can click on over to the "Related Topics" area on the right-hand side of the homepage, where they will find resources on everything from ankle injuries to general wellness. Their homepage also contains sections like "Basics", "Research", and "Multimedia & Cool Tools". Two items that are definitely worth checking out are the tennis elbow tutorial and the basic overview of sports injuries offered by the National Institute of Arthritis and Musculoskeletal and Skin Diseases.

  8. Telehealthcare for chronic obstructive pulmonary disease: Cochrane Review and meta-analysis

    PubMed Central

    McLean, Susannah; Nurmatov, Ulugbek; Liu, Joseph LY; Pagliari, Claudia; Car, Josip; Sheikh, Aziz

    2012-01-01

    Background Chronic obstructive pulmonary disease (COPD) is common. Telehealthcare, involving personalised health care over a distance, is seen as having the potential to improve care for people with COPD. Aim To systematically review the effectiveness of telehealthcare interventions in COPD to improve clinical and process outcomes. Design and setting Cochrane Systematic Review of randomised controlled trials. Methods The study involved searching the Cochrane Airways Group Register of Trials, which is derived from the Cochrane Central Register of Controlled Trials, MEDLINE®, embase™, and CINAHL®, as well as searching registers of ongoing and unpublished trials. Randomised controlled trials comparing a telehealthcare intervention with a control intervention in people with a clinical diagnosis of COPD were identified. The main outcomes of interest were quality of life and risk of emergency department visit, hospitalisation, and death. Two authors independently selected trials for inclusion and extracted data. Study quality was assessed using the Cochrane Collaboration’s risk of bias method. Meta-analysis was undertaken using fixed effect and/or random effects modelling. Results Ten randomised controlled trials were included. Telehealthcare did not improve COPD quality of life: mean difference –6.57 (95% confidence interval [CI] = –13.62 to 0.48). However, there was a significant reduction in the odds ratios (ORs) of emergency department attendance (OR = 0.27; 95% CI = 0.11 to 0.66) and hospitalisation (OR = 0.46; 95% CI = 0.33 to 0.65). There was a non-significant change in the OR of death (OR = 1.05; 95% CI = 0.63 to 1.75). Conclusion In COPD, telehealthcare interventions can significantly reduce the risk of emergency department attendance and hospitalisation, but has little effect on the risk of death. PMID:23211177

  9. SPELLING CORRECTION IN THE PUBMED SEARCH ENGINE.

    PubMed

    Wilbur, W John; Kim, Won; Xie, Natalie

    2006-11-01

    It is known that users of internet search engines often enter queries with misspellings in one or more search terms. Several web search engines make suggestions for correcting misspelled words, but the methods used are proprietary and unpublished to our knowledge. Here we describe the methodology we have developed to perform spelling correction for the PubMed search engine. Our approach is based on the noisy channel model for spelling correction and makes use of statistics harvested from user logs to estimate the probabilities of different types of edits that lead to misspellings. The unique problems encountered in correcting search engine queries are discussed and our solutions are outlined. PMID:18080004

  10. Archie Cochrane and his vision for evidence-based medicine

    PubMed Central

    Shah, Hriday M.; Chung, Kevin C.

    2009-01-01

    Archibald (Archie) Cochrane's most influential mark on healthcare was his 1971 publication, “Effectiveness and Efficiency.” This book strongly criticized the lack of reliable evidence behind many of the commonly accepted healthcare interventions at the time. His criticisms spurred rigorous evaluations of healthcare interventions and highlighted the need for evidence in medicine. His call for a collection of systematic reviews led to the creation of The Cochrane Collaboration. Archie Cochrane was a visionary person who helped lay down much of the foundation for evidence-based medicine. This paper will introduce evidence-based medicine to Plastic Surgery by tracing its history to the seminal efforts by Archie Cochrane. PMID:19730323

  11. Finding biomedical categories in Medline®

    PubMed Central

    2012-01-01

    Background There are several humanly defined ontologies relevant to Medline. However, Medline is a fast growing collection of biomedical documents which creates difficulties in updating and expanding these humanly defined ontologies. Automatically identifying meaningful categories of entities in a large text corpus is useful for information extraction, construction of machine learning features, and development of semantic representations. In this paper we describe and compare two methods for automatically learning meaningful biomedical categories in Medline. The first approach is a simple statistical method that uses part-of-speech and frequency information to extract a list of frequent nouns from Medline. The second method implements an alignment-based technique to learn frequent generic patterns that indicate a hyponymy/hypernymy relationship between a pair of noun phrases. We then apply these patterns to Medline to collect frequent hypernyms as potential biomedical categories. Results We study and compare these two alternative sets of terms to identify semantic categories in Medline. We find that both approaches produce reasonable terms as potential categories. We also find that there is a significant agreement between the two sets of terms. The overlap between the two methods improves our confidence regarding categories predicted by these independent methods. Conclusions This study is an initial attempt to extract categories that are discussed in Medline. Rather than imposing external ontologies on Medline, our methods allow categories to emerge from the text. PMID:23046816

  12. How to improve your PubMed/MEDLINE searches: 1. background and basic searching.

    PubMed

    Fatehi, Farhad; Gray, Leonard C; Wootton, Richard

    2013-12-01

    PubMed provides free access via the Internet to more than 23 million records, of which over 19 million are from the MEDLINE database of journal articles. PubMed also provides access to other databases, such as the NCBI Bookshelf. To perform a basic search, you can simply enter the search terms or the concept that you are looking for in the search box. However, taking care to clarify your key concepts may save much time later on, because a non-specific search is likely to produce an overwhelming number of result hits. One way to make your search more specific is to specify which field you want to search using field tags. By default, the results of a search are sorted by the date added to PubMed and displayed in summary format with 20 result hits (records) on each page. In summary format, the title of the article, list of authors, source of information (e.g., journal name followed by date of publication, volume, issue, pages) and the unique PubMed record number called the PubMed identifier (PMID) are shown. Although information is stored about the articles, PubMed/MEDLINE does not store the full text of the papers themselves. However, PubMedCentral (PMC) stores more than 2.8 million articles (roughly 10% of the articles in PubMed) and provides access to them for free to the users. PMID:24197398

  13. Medline Plus: Herbal Medicine

    NSDL National Science Digital Library

    From the world of Aloe Vera to yohimbe, this site leaves no herbal medicines unexplored. As part of the Medline Plus omnibus site which was created by the U.S. National Library of Medicine and the National Institutes of Health, this particular section covers many aspects of the world of herbal medicine. First-time visitors will want to start by looking over the background essays on the use of botanical dietary supplements offered from the Office of Dietary Supplements. After that, they should browse through sections that include "Basics", "Learn More", "Research", and "Reference Shelf". They can also just scroll down through the homepage, which includes overviews on the use of different herbs and supplements. Those persons looking for the latest information about research findings on herbs and topical treatments can look within the "Latest News" listings, which are updated frequently. Researchers will appreciate the inclusion of a "Clinical Trials" area which provides the latest information about ongoing clinical trials that draw on various aspects of herbal medicine.

  14. PubMed advanced exercise: MeSH Searching

    E-print Network

    Rzepa, Henry S.

    1 PubMed ­ advanced exercise: MeSH Searching You can search PubMed by using Medical Subject. For the following exercise, please search PubMed using: a) search terms that feature within the following. The exercise 1. In this exercise, we will compare results from both "standard" and MeSH searches. You can enter

  15. KNOT CONCORDANCE AND HIGHER-ORDER BLANCHFIELD TIM D. COCHRAN

    E-print Network

    Leidy, Constance

    KNOT CONCORDANCE AND HIGHER-ORDER BLANCHFIELD DUALITY TIM D. COCHRAN , SHELLY HARVEY supported by NSF DMS-0539044 and The Alfred P. Sloan Foundation. 1 #12;2 TIM D. COCHRAN , SHELLY HARVEY invariants. In the late 60's Levine [30] (see also [42]) defined an epimorphism from C to Z Z 2 Z 4 , given

  16. Contact Us: MedlinePlus

    MedlinePLUS

    ... indexrwd.cfm?lang=en Contact the U.S. National Library of Medicine Thank you for visiting MedlinePlus. We ... Sierra Leone Singapore Slovakia Slovenia Solomon Islands South Africa Spain Sri Lanka Sudan Suriname Sweden Switzerland Taiwan ...

  17. Annotating patents with Medline MeSH codes via citation mapping.

    PubMed

    Griffin, Thomas D; Boyer, Stephen K; Councill, Isaac G

    2010-01-01

    Both patents and Medline are important document collections for discovering new relationships between chemicals and biology, searching for prior art for patent applications and retrieving background knowledge for current research activities. Finding relevance to a topic within patents is often made difficult by poor categorization, badly written descriptions, and even intentional obfuscation. Unlike patents, the Medline corpus has Medical Subject Heading (MeSH) keywords manually added to their articles, giving a medically relevant taxonomy to the 18 million article abstracts. Our work attempts to accurately recognize the citations made in patents to Medline-indexed articles, linking them to their corresponding PubMed ID and exploiting the associated MeSH to enhance patent search by annotating the referencing patents with their Medline citations' MeSH codes. The techniques, system features, and benefits are explained. PMID:20865561

  18. Review of Cochrane Reviews on Acupuncture: How Chinese Resources Contribute to Cochrane Reviews

    PubMed Central

    Jiao, Shuang; Tsutani, Kiichiro

    2013-01-01

    Abstract Background Cochrane Systematic Reviews (CSRs) are frequently referenced by acupuncture efficacy studies currently. In this study, the CSRs on acupuncture are reviewed, and the disease fields they covered and the conclusions they reached are analyzed. In order to explore the potential contribution to CSRs by Chinese resources, the authors analyzed whether the participation of Chinese reviewers, the utilization of Chinese databases, and the inclusion of Chinese clinical trials would affect the positive conclusion ratios of the CSRs. Methods Acupuncture-related CSRs in the Cochrane Library were searched and classified based on the International Classification of Diseases-10 (ICD-10). The CSRs were further designated as positive or negative according to the conclusion statements. CSRs with the participation of Chinese reviewers, the utilization of Chinese databases, or the inclusion of Chinese clinical trials were extracted, and the positive ratios of conclusions were compared separately with corresponding CSRs without those three Chinese resources. Results Thirty-two (32) CSRs were identified, 9 (28.1%) of which reached positive conclusions. The CSRs with positive conclusions were mainly about multifarious pains, nausea and vomiting, and functional disorders. Seventeen (17; 53.1%) included the participation of Chinese reviewers, 18 (56.3%) involved the utilization of Chinese databases, and 20 (62.5%) included Chinese clinical trials. No differences on the positive conclusion ratios were observed between CSRs with reviewers from Chinese institutions and those that did not (odds ratio [OR]: 0.32, 95% confidence interval [CI]: 0.06, 1.62), the utilization of Chinese databases and those that did not (OR: 0.51, 95% CI: 0.11, 2.44), or the inclusion of Chinese clinical trials and those that did not (OR: 1.29, 95% CI: 0.26, 6.49). Conclusions Most CSRs on acupuncture are inconclusive. No significant differences regarding the positive conclusion ratios were found between the CSRs with or without the utilization of Chinese resources. PMID:23410528

  19. Bosnian and Herzegovinian medical scientists in PubMed database.

    PubMed

    Masic, Izet

    2013-01-01

    In this paper it is shortly presented PubMed as one of the most important on-line databases of the scientific biomedical literature. Also, the author has analyzed the most cited authors, professors of the medical faculties in Bosnia and Herzegovina, from the published papers in the biomedical journals abstracted and indexed in PubMed. PMID:24341067

  20. Developing search strategies in medline on the occupational origin of diseases

    Microsoft Academic Search

    Frederieke Schaafsma; Carel Hulshof; J. H. A. M. Verbeek; Jurriaan Bos; Heleen Dyserinck; Dijk van F. J. H

    2006-01-01

    Background In order to support occupational health practitioners, researchers, and experts (clinical librarians, guideline developers) who search the scientific literature in PubMed (Medline), we developed and evaluated an easy-to-use and effective search strategy. Methods We tested different combinations of search terms, in answering four case vignettes calculating sensitivity and precision in retrieving literature from a gold standard. The use of

  1. MedlinePlus Connect: Technical Information

    MedlinePLUS

    ... to keep you informed of updates and enhancements. Web Application The MedlinePlus Connect Web application responds to ... Connect response pages, visit the Web application demonstration . Web Service Using the MedlinePlus Connect Web service, a ...

  2. MedlinePlus Survey Results 2012

    MedlinePLUS

    ... nlm.nih.gov/medlineplus/survey2012/index.html MedlinePlus Survey Results 2012 To use the sharing features on this page, please enable JavaScript. These survey results describe MedlinePlus and MedlinePlus en español users. ...

  3. MEDLINE on the Internet: "Healthier" than Before?

    ERIC Educational Resources Information Center

    Buntrock, Robert E.

    1997-01-01

    Examines some of the many Internet/World Wide Web versions of MEDLINE and reports whether the file is "healthier" now than it was before. Describes two search examples and two non-National Library of Medicine Web MEDLINE sites. Notes that for MEDLINE searching, the user should pick a couple of sites and perform a personal comparisons and…

  4. Author Name Disambiguation in MEDLINE

    PubMed Central

    TORVIK, VETLE I.; SMALHEISER, NEIL R.

    2009-01-01

    Background We recently described “Author-ity,” a model for estimating the probability that two articles in MEDLINE, sharing the same author name, were written by the same individual. Features include shared title words, journal name, coauthors, medical subject headings, language, affiliations, and author name features (middle initial, suffix, and prevalence in MEDLINE). Here we test the hypothesis that the Author-ity model will suffice to disambiguate author names for the vast majority of articles in MEDLINE. Methods Enhancements include: (a) incorporating first names and their variants, email addresses, and correlations between specific last names and affiliation words; (b) new methods of generating large unbiased training sets; (c) new methods for estimating the prior probability; (d) a weighted least squares algorithm for correcting transitivity violations; and (e) a maximum likelihood based agglomerative algorithm for computing clusters of articles that represent inferred author-individuals. Results Pairwise comparisons were computed for all author names on all 15.3 million articles in MEDLINE (2006 baseline), that share last name and first initial, to create Author-ity 2006, a database that has each name on each article assigned to one of 6.7 million inferred author-individual clusters. Recall is estimated at ~98.8%. Lumping (putting two different individuals into the same cluster) affects ~0.5% of clusters, whereas splitting (assigning articles written by the same individual to >1 cluster) affects ~2% of articles. Impact The Author-ity model can be applied generally to other bibliographic databases. Author name disambiguation allows information retrieval and data integration to become person-centered, not just document-centered, setting the stage for new data mining and social network tools that will facilitate the analysis of scholarly publishing and collaboration behavior. Availability The Author-ity 2006 database is available for nonprofit academic research, and can be freely queried via http://arrowsmith.psych.uic.edu. PMID:20072710

  5. Parenting Training for Intellectually Disabled Parents: A Cochrane Systematic Review

    ERIC Educational Resources Information Center

    Coren, Esther; Thomae, Manuela; Hutchfield, Jemeela

    2011-01-01

    Objectives: This article presents a Cochrane/Campbell systematic review of the evidence on the effect of parent training to support the parenting of parents with intellectual disabilities. Method: Randomized controlled trials (RCTs) comparing parent training interventions for parents with intellectual disability with usual care or with a control…

  6. Avoidable Ignorance and the Role of Cochrane and Campbell Reviews

    ERIC Educational Resources Information Center

    Gambrill, Eileen

    2015-01-01

    The Campbell and Cochrane Collaborations were created to reveal the evidentiary status of claims focusing especially on the effectiveness of specific interventions. Such reviews are constrained by the population of studies available and biases that may influence this availability such as preferred framing of problems. This highlights the…

  7. Retrieval of diagnostic and treatment studies for clinical use through PubMed and PubMed's Clinical Queries filters

    Microsoft Academic Search

    Cynthia Lokker; R Brian Haynes; Nancy L Wilczynski; K Ann McKibbon; Stephen D Walter

    2011-01-01

    ObjectiveClinical Queries filters were developed to improve the retrieval of high-quality studies in searches on clinical matters. The study objective was to determine the yield of relevant citations and physician satisfaction while searching for diagnostic and treatment studies using the Clinical Queries page of PubMed compared with searching PubMed without these filters.Materials and methodsForty practicing physicians, presented with standardized treatment

  8. Searching for unpublished data for Cochrane reviews: cross sectional study

    PubMed Central

    2013-01-01

    Objective To describe the experiences of authors of Cochrane reviews in searching for, getting access to, and using unpublished data. Design Cross sectional study. Setting Cochrane reviews. Participants 2184 corresponding authors of Cochrane reviews as of May 2012. Main outcome measure Frequencies of responses to open ended and closed questions in an online survey. Results Of 5915 authors contacted by email, 2184 replied (36.9% response rate). Of those, 1656 (75.8%) had searched for unpublished data. In 913 cases (55.1% of 1656), new data were obtained and we received details about these data for 794 data sources. The most common data source was “trialists/investigators,” accounting for 73.9% (n=587) of the 794 data sources. Most of the data were used in the review (82.0%, 651/794) and in 53.4% (424/794) of cases data were provided in less than a month. Summary data were most common, provided by 50.8% (403/794) of the data sources, whereas 20.5% (163/794) provided individual patient data. In only 6.3% (50/794) of cases were data reported to have been obtained from the manufacturers, and this group waited longer and had to make more contacts to get the data. The data from manufacturers were less likely to be for individual patients and less likely to be used in the review. Data from regulatory agencies accounted for 3.0% (24/794) of the obtained data. Conclusions Most authors of Cochrane reviews who searched for unpublished data received useful information, primarily from trialists. Our response rate was low and the authors who did not respond were probably less likely to have searched for unpublished data. Manufacturers and regulatory agencies were uncommon sources of unpublished data. PMID:23613540

  9. Prevention of bacterial meningitis: an overview of Cochrane systematic reviews.

    PubMed

    Prasad, Kameshwar; Karlupia, Neha

    2007-10-01

    Acute bacterial meningitis (ABM) is an acute inflammation of leptomeninges caused by bacteria, and has a case fatality rate of 10-30%. Prevention strategies, such as vaccination and prophylactic antibiotics, can prevent ABM and have substantial public health impact by reducing the disease burden associated with it. The aim of this paper is to summarize the main findings from Cochrane systematic reviews that have considered the evidence for measures to prevent ABM. We assessed the evidence available in the Cochrane Library. We found five Cochrane reviews focused on the prevention of ABM; three with use of vaccination and two with prophylactic antibiotics. Polysaccharide serogroup A vaccine is strongly protective for the first year, against serogroup A meningococcal meningitis in adults and children over 5 years of age. Meningococcal serogroup C conjugate (MCC) vaccine is safe and effective in infants. Haemophilus influenzae type b (Hib) vaccine is safe and effective against Hib-invasive disease at all ages. Ceftriaxone, rifampicin and ciprofloxacin are the most effective prophylactic antibiotics against Neisseria meningitidis. There is sufficient evidence to use polysaccharide serogroup A vaccine to prevent serogroup A meningococcal meningitis, MCC conjugate vaccines to prevent meningococcal C meningitis and Hib conjugate vaccine to prevent Hib infections. More studies are needed to evaluate the effects of Hib conjugate vaccine on mortality. Further, studies are required to compare the relative effectiveness of ceftriaxone, ciprofloxacin and rifampicin in chemoprophylaxis against meningococcal infection. PMID:17706408

  10. How Complementary and Alternative Medicine Practitioners Use PubMed

    PubMed Central

    Quint-Rapoport, Mia

    2007-01-01

    Background PubMed is the largest bibliographic index in the life sciences. It is freely available online and is used by professionals and the public to learn more about medical research. While primarily intended to serve researchers, PubMed provides an array of tools and services that can help a wider readership in the location, comprehension, evaluation, and utilization of medical research. Objective This study sought to establish the potential contributions made by a range of PubMed tools and services to the use of the database by complementary and alternative medicine practitioners. Methods In this study, 10 chiropractors, 7 registered massage therapists, and a homeopath (N = 18), 11 with prior research training and 7 without, were taken through a 2-hour introductory session with PubMed. The 10 PubMed tools and services considered in this study can be divided into three functions: (1) information retrieval (Boolean Search, Limits, Related Articles, Author Links, MeSH), (2) information access (Publisher Link, LinkOut, Bookshelf ), and (3) information management (History, Send To, Email Alert). Participants were introduced to between six and 10 of these tools and services. The participants were asked to provide feedback on the value of each tool or service in terms of their information needs, which was ranked as positive, positive with emphasis, negative, or indifferent. Results The participants in this study expressed an interest in the three types of PubMed tools and services (information retrieval, access, and management), with less well-regarded tools including MeSH Database and Bookshelf. In terms of their comprehension of the research, the tools and services led the participants to reflect on their understanding as well as their critical reading and use of the research. There was universal support among the participants for greater access to complete articles, beyond the approximately 15% that are currently open access. The abstracts provided by PubMed were felt to be necessary in selecting literature to read but entirely inadequate for both evaluating and learning from the research. Thus, the restrictions and fees the participants faced in accessing full-text articles were points of frustration. Conclusions The study found strong indications of PubMed’s potential value in the professional development of these complementary and alternative medicine practitioners in terms of engaging with and understanding research. It provides support for the various initiatives intended to increase access, including a recommendation that the National Library of Medicine tap into the published research that is being archived by authors in institutional archives and through other websites. PMID:17613489

  11. Visit the new MedlinePlus | NIH MedlinePlus the Magazine

    MedlinePLUS

    ... this page please turn Javascript on. Visit the new MedlinePlus Past Issues / Fall 2010 Table of Contents ... trusted, up-to-date medical information Visit the new MedlinePlus From the top medical experts at the ...

  12. MedlinePlus FAQ: Can you tell me how to cite MedlinePlus pages?

    MedlinePLUS

    ... date you saw the information online. Homepage MedlinePlus [Internet]. Bethesda (MD): National Library of Medicine (US); [updated ... add information about the topic being cited : MedlinePlus [Internet]. Bethesda (MD): National Library of Medicine (US); [updated ...

  13. Spelling correction in the PubMed search engine

    Microsoft Academic Search

    W. John Wilbur; Won Kim; Natalie Xie

    2006-01-01

    It is known that users of internet search engines often enter queries with misspellings in one or more search terms. Several web search engines make suggestions for correcting misspelled words, but the methods used are proprietary and unpublished to our knowledge. Here we describe the methodology we have developed to perform spelling correction for the PubMed search engine. Our approach

  14. PubMed Central: An Archive of Life Science Journals

    NSDL National Science Digital Library

    There has been an increased interest in open source publishing as of late, and the U.S government has gotten involved recently with the creation of PubMed Central (through the National Center for Biotechnology Information and the National Library of Medicine) in 2000. PubMed Central is a digital archive of life science journal literature which offers free and complete access to the contents of approximately 50 peer-reviewed journals, such as Applied and Environmental Microbiology, Dynamic Medicine, and the Journal of Bacteriology. The search engine is fairly straightforward, as users may elect to enter author names, journal titles in full, or by keywords. All told, PubMed currently contains many thousands of articles, many of which will be of great interest to researchers and students in these fields. Perhaps the most crucial features of PubMed are summarized in this passage from their overview section, which remarks thusly: "It also makes it possible to integrate the literature with a variety of other information resources such as sequence databases and other factual databases that are available to scientists, clinicians, and everyone else interested in the life sciences. The intentional and serendipitous discoveries that such links might foster excite us and stimulate us to move forward."

  15. 4. ALABAMA, PICKENS CO., COCHRANE COLLAPSED RAILROAD BRIDGE 1.5 miles ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. ALABAMA, PICKENS CO., COCHRANE COLLAPSED RAILROAD BRIDGE 1.5 miles N. from Cochrane on Ala. route 17. Western half of collapsed Alabama, Tenn. & Northern RR. Bridge Jack Donnell, Columbus, Ms., photographer, 1973. Copy by Sarcone Photography, Columbs, Ms Sep 1978. - Bridges of the Upper Tombigbee River Valley, Cochrane, Pickens County, AL

  16. 1. ALABAMA, PICKENS CO., COCHRANE HIGHWAY BRIDGE 1.5 miles N. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. ALABAMA, PICKENS CO., COCHRANE HIGHWAY BRIDGE 1.5 miles N. from Cochrane on Ala. route 17 Aerial view of Milner bridge, from SW. David J. Kaminsky, Architectural Photography, Atlanta Ga. Aug 1978. - Bridges of the Upper Tombigbee River Valley, Cochrane, Pickens County, AL

  17. 6. ALABAMA, PICKENS CO., COCHRANE RAILROAD BRIDGE 1.5 miles N. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. ALABAMA, PICKENS CO., COCHRANE RAILROAD BRIDGE 1.5 miles N. from Cochrane on Ala. route 17 Copy of photo by Jack Donnell, Columbus, Ms., 192. Shows center turn span and part of one fixed span. Sarcone Photography, Columbus, Ms. Sep 1978. - Bridges of the Upper Tombigbee River Valley, Cochrane, Pickens County, AL

  18. 3. ALABAMA, PICKENS CO., COCHRANE RAILROAD BRIDGE AND FERRY 1.5 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. ALABAMA, PICKENS CO., COCHRANE RAILROAD BRIDGE AND FERRY 1.5 miles N. from Cochrane on Ala. route 17. Copy of photo by Jack Donnell, Columbus, Ms., 1927. West ferry landing ferry barge, andcar in foreground. Alabama, Tennessee & Northern (later Frisco) RR bridge in background. Sarcone Photography, Columbus, Ms. Sep 1978. - Bridges of the Upper Tombigbee River Valley, Cochrane, Pickens County, AL

  19. 5. ALABAMA, PICKENS CO., COCHRANE COLLAPSED RAILROAD BRIDGE 1.5 miles ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. ALABAMA, PICKENS CO., COCHRANE COLLAPSED RAILROAD BRIDGE 1.5 miles N. from Cochrane on Ala. route 17. Copy of photo by Jack Donnell, Columbus, Ms., after bridge collapsed in 1973. Shows broken turn span and overturned center pier. Sarcone Photography, Columbus, Ms. Sep 1978. - Bridges of the Upper Tombigbee River Valley, Cochrane, Pickens County, AL

  20. 2. ALABAMA, PICKENS, CO., COCHRANE HIGHWAY BRIDGE 1.5 miles N. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. ALABAMA, PICKENS, CO., COCHRANE HIGHWAY BRIDGE 1.5 miles N. from Cochrane on Ala. route 17. Aerial view of Milner bridge, from SE. David J. Kaminsky, Architecturl Photography, Atlanta Ga. Aug 1978. - Bridges of the Upper Tombigbee River Valley, Cochrane, Pickens County, AL

  1. Information content in Medline record fields

    Microsoft Academic Search

    Ronald N. Kostoff; Joel A. Block; Jesse A. Stump; Kirstin M. Pfeil

    2004-01-01

    Background: The authors have been conducting text mining analyses (extraction of useful information from text) of Medline records, using Abstracts as the main data source. For literature-based discovery, and other text mining applications as well, all records in a discipline need to be evaluated for determining prior art. Many Medline records do not contain Abstracts, but typically contain Titles and

  2. Enhancing access to reports of randomized trials published world-wide – the contribution of EMBASE records to the Cochrane Central Register of Controlled Trials (CENTRAL) in The Cochrane Library

    PubMed Central

    Lefebvre, Carol; Eisinga, Anne; McDonald, Steve; Paul, Nina

    2008-01-01

    Background Randomized trials are essential in assessing the effects of healthcare interventions and are a key component in systematic reviews of effectiveness. Searching for reports of randomized trials in databases is problematic due to the absence of appropriate indexing terms until the 1990s and inconsistent application of these indexing terms thereafter. Objectives The objectives of this study are to devise a search strategy for identifying reports of randomized trials in EMBASE which are not already indexed as trials in MEDLINE and to make these reports easily accessible by including them in the Cochrane Central Register of Controlled Trials (CENTRAL) in The Cochrane Library, with the permission of Elsevier, the publishers of EMBASE. Methods A highly sensitive search strategy was designed for EMBASE based on free-text and thesaurus terms which occurred frequently in the titles, abstracts, EMTREE terms (or some combination of these) of reports of trials indexed in EMBASE. This search strategy was run against EMBASE from 1980 to 2005 (1974 to 2005 for four of the terms) and records retrieved by the search, which were not already indexed as randomized trials in MEDLINE, were downloaded from EMBASE, printed and read. An analysis of the language of publication was conducted for the reports of trials published in 2005 (the most recent year completed at the time of this study). Results Twenty-two search terms were used (including nine which were later rejected due to poor cumulative precision). More than a third of a million records were downloaded and scanned and approximately 80,000 reports of trials were identified which were not already indexed as randomized trials in MEDLINE. These are now easily identifiable in CENTRAL, in The Cochrane Library. Cumulative sensitivity ranged from 0.1% to 60% and cumulative precision ranged from 8% to 61%. The truncated term 'random$' identified 60% of the total number of reports of trials but only 35% of the more than 130,000 records retrieved by this term were reports of trials. The language analysis for the sample year 2005 indicated that of the 18,427 reports indexed as randomized trials in MEDLINE, 959 (5%) were in languages other than English. The EMBASE search identified an additional 658 reports in languages other than English, of which the highest number were in Chinese (320). Conclusion The results of the search to date have greatly increased access to reports of trials in EMBASE, especially in some languages other than English. The search strategy used was subjectively derived from a small 'gold standard' set of test records and was not validated in an independent test set. We intend to design an objectively-derived validated search strategy using logistic regression based on the frequency of occurrence of terms in the approximately 80,000 reports of randomized trials identified compared with the frequency of these terms across the entire EMBASE database. PMID:18826567

  3. The public health future of melanoma control. - PubMed - NCBI

    Science.gov Websites

    Manual NCBI News PubMed PubMed Central (PMC) PubMed Clinical Queries PubMed Health All Literature Resources... Proteins BioSystems BLAST (Basic Local Alignment Search Tool)...

  4. Multisystemic infection with an Acanthamoeba sp in a dog. - PubMed...

    Science.gov Websites

    Manual NCBI News PubMed PubMed Central (PMC) PubMed Clinical Queries PubMed Health All Literature Resources... Proteins BioSystems BLAST (Basic Local Alignment Search Tool)...

  5. SNP typing in forensic genetics: a review. - PubMed - NCBI

    Science.gov Websites

    Manual NCBI News PubMed PubMed Central (PMC) PubMed Clinical Queries PubMed Health All Literature Resources... Proteins BioSystems BLAST (Basic Local Alignment Search Tool)...

  6. Hot water for handwashing--where is the proof? - PubMed - NCBI

    Science.gov Websites

    Manual NCBI News PubMed PubMed Central (PMC) PubMed Clinical Queries PubMed Health All Literature Resources... Proteins BioSystems BLAST (Basic Local Alignment Search Tool)...

  7. The children of atomic bomb survivors: a synopsis. - PubMed ...

    Science.gov Websites

    Manual NCBI News PubMed PubMed Central (PMC) PubMed Clinical Queries PubMed Health All Literature Resources... Proteins BioSystems BLAST (Basic Local Alignment Search Tool)...

  8. Doses to children from intakes by ingestion. - PubMed - NCBI

    Science.gov Websites

    Manual NCBI News PubMed PubMed Central (PMC) PubMed Clinical Queries PubMed Health All Literature Resources... Proteins BioSystems BLAST (Basic Local Alignment Search Tool)...

  9. A classifier for the SNP-based inference of ancestry. - PubMed...

    Science.gov Websites

    Manual NCBI News PubMed PubMed Central (PMC) PubMed Clinical Queries PubMed Health All Literature Resources... Proteins BioSystems BLAST (Basic Local Alignment Search Tool)...

  10. Excision and skin grafting of thermal burns. - PubMed - NCBI

    Science.gov Websites

    Manual NCBI News PubMed PubMed Central (PMC) PubMed Clinical Queries PubMed Health All Literature Resources... Proteins BioSystems BLAST (Basic Local Alignment Search Tool)...

  11. Patient navigation: state of the art or is it science? - PubMed...

    Science.gov Websites

    Manual NCBI News PubMed PubMed Central (PMC) PubMed Clinical Queries PubMed Health All Literature Resources... Proteins BioSystems BLAST (Basic Local Alignment Search Tool)...

  12. Routine vaccines across the life span, 2005. - PubMed - NCBI

    Science.gov Websites

    Manual NCBI News PubMed PubMed Central (PMC) PubMed Clinical Queries PubMed Health All Literature Resources... Proteins BioSystems BLAST (Basic Local Alignment Search Tool)...

  13. Microbial keratitis and the role of rub and rinsing. - PubMed...

    Science.gov Websites

    Manual NCBI News PubMed PubMed Central (PMC) PubMed Clinical Queries PubMed Health All Literature Resources... Proteins BioSystems BLAST (Basic Local Alignment Search Tool)...

  14. Vulnerability of children: more than a question of age. - PubMed...

    Science.gov Websites

    Manual NCBI News PubMed PubMed Central (PMC) PubMed Clinical Queries PubMed Health All Literature Resources... Proteins BioSystems BLAST (Basic Local Alignment Search Tool)...

  15. Blast eye injuries: a review for first responders. - PubMed ...

    Science.gov Websites

    Manual NCBI News PubMed PubMed Central (PMC) PubMed Clinical Queries PubMed Health All Literature Resources... Proteins BioSystems BLAST (Basic Local Alignment Search Tool)...

  16. What is PubMed? PubMed is a resource provided by the US National Institutes of Health. Its subject coverage is biomedicine and health,

    E-print Network

    Rzepa, Henry S.

    PubMed What is PubMed? PubMed is a resource provided by the US National Institutes of Health. Its subject coverage is biomedicine and health, along with portions of behavioural sciences, bioengineering'; `Dermatis' is listed within `Skin diseases'. How to search using MeSH: Select MeSH from the drop-down menu

  17. Bibliometric analysis of leishmaniasis research in Medline (1945-2010)

    PubMed Central

    2013-01-01

    Background Publications are often used as a measure of success of research work. Leishmaniasis is considered endemic in 98 countries, most of which are developing. This article describes a bibliometric review of the literature on leishmaniasis research indexed in PubMed during a 66-year period. Methods Medline was used via the PubMed online service of the US National Library of Medicine. The search strategy was Leishmania [MeSH] or leishmaniasis [MeSH] from 1 January 1945 until 31 December 2010. Neither language nor document type restrictions were employed. Results A total of 20,780 references were retrieved. The number of publications increased steadily over time, with 3,380 publications from 1945-1980 to 8,267 from 2001-2010. Leishmaniasis documents were published in 1,846 scientific journals, and Transactions of the Royal Society of Tropical Medicine and Hygiene (4.9%) was the top one. The USA was the predominant country by considering the first author’s institutional address (16.8%), followed by Brazil (14.9%), and then India (9.0%), however Brazil leads the scientific output in 2001-2010 period (18.5%), followed by the USA (13.5%) and India (10%). The production ranking changed when the number of publications was normalised by population (Israel and Switzerland), by gross domestic product (Nepal and Tunisia), and by gross national income per capita (India and Ethiopia). For geographical area, Europe led (31.7%), followed by Latin America (24.5%). Conclusions We have found an increase in the number of publications in the field of leishmaniasis. The USA and Brazil led scientific production on leishmaniasis research. PMID:23497410

  18. MedlinePlus Connect: Email List

    MedlinePLUS

    ... nih.gov/medlineplus/connect/emaillist.html MedlinePlus Connect: Email List To use the sharing features on this ... developments and exchange ideas with your colleagues. This email list will be useful for health IT developers ...

  19. MedlinePlus Milestones: 1998-present

    MedlinePLUS

    ... releases a new edition of the A.D.A.M. Medical Encyclopedia that includes Patient Instruction articles covering ... See the press release .) April The A.D.A.M. Medical Encyclopedia is incorporated into MedlinePlus. The encyclopedia ...

  20. MedlinePlus Connect: Web Application

    MedlinePLUS

    ... nih.gov/medlineplus/connect/application.html MedlinePlus Connect: Web Application To use the sharing features on this ... please see our guidelines and instructions on linking. Web Application Overview The API for the Web application ...

  1. Earthquakes - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Kreyol (Haitian Creole) PDF National Child Traumatic Stress Network Spanish (español) Terremotos Characters not displaying correctly on this page? See language display issues . Return to the MedlinePlus Health Information ...

  2. Overview of Reviews The prevention of eczema in infants and children: an overview of Cochrane and non-Cochrane reviews

    PubMed Central

    Foisy, Michelle; Boyle, Robert J.; Chalmers, Joanne R.; Simpson, Eric L.; Williams, Hywel C.

    2012-01-01

    Background Eczema is the most common inflammatory skin disease of childhood, characterized by an itchy red rash that usually involves the face and skin folds. There is currently no curative treatment for eczema, so the reduction of eczema incidence through disease prevention is a desirable goal. Potential interventions for preventing eczema include exclusive breastfeeding, hydrolysed protein formulas and soy formulas when bottle feeding, maternal antigen avoidance, omega oil supplementation, prebiotics and probiotics. Objectives This overview of reviews aims to present the current body of data from Cochrane and non-Cochrane reviews to provide the most up-to-date evidence on the efficacy and safety of interventions to prevent eczema in infants and children at different risk levels for developing allergic disease. Methods Our pool of Cochrane and non-Cochrane reviews came from the 2010 United Kingdom National Health Service (NHS) Evidence Skin Disorders Annual Evidence Updates Mapping Exercise on Atopic Eczema. This group used a comprehensive search strategy last conducted in August 2010 to identify all systematic reviews on eczema prevention. We identified all reviews that met our pre-specified inclusion criteria, and data were extracted, analysed, compiled into tables and synthesized using quantitative and qualitative methods. Main results Seven systematic reviews containing 39 relevant trials with 11 897 participants were included in this overview. Overall, there was no clear evidence that any of the main interventions reviewed reduced eczema incidence. In subgroup analyses of infants at high risk of allergic disease, an observational study found that exclusive breastfeeding for at least six months compared with introduction of solids at three to six months decreased the incidence of eczema by 60% (risk ratio (RR): 0.40; 95% confidence interval (CI): 0.21, 0.78), and a randomized controlled trial found that prebiotics compared with no prebiotics decreased incidence by 58% (RR: 0.42; 95% CI: 0.21, 0.84). However, each of these findings was based on the results of a single small trial, and no intervention reduced eczema incidence beyond the first two years of life. Although we pre-specified incidence of atopic eczema (i.e. eczema associated with immunoglobulin E (IgE) sensitization) as a primary outcome, data on whether participants diagnosed with eczema were truly atopic were largely lacking from systematic reviews. Similarly, data on atopy, measured using skin prick tests or specific IgE tests to allergens, were not reported in many reviews. No interventions were found to decrease atopy when reported. Adverse events data were generally lacking, but data from a trial of probiotics versus no probiotics showed significantly more spitting up in the first one (RR: 1.88; 95% CI: 1.03, 3.45) and two (RR: 1.69; 95% CI: 1.02, 2.80) months of life, but no overall increase in risk of gastrointestinal symptoms in the first year. Authors’ conclusions Although there is currently no clear evidence showing that any of the interventions examined in this overview prevent eczema in participants not selected for risk of allergic disease, there is some evidence that exclusive breastfeeding for at least six months and prebiotics might reduce eczema incidence in high-risk participants. However, these conclusions are based on limited evidence with methodological shortcomings. Future research on prevention of eczema is needed and should examine different types of hydrolysed formulas, prebiotics and probiotics, as well as enhancement of the skin barrier and other novel approaches in infants at different risk levels for developing allergic disease. PMID:22822349

  3. MedlinePlus FAQ: What's New on Medline Plus Page and Email Updates

    MedlinePLUS

    ... faq/whatsnew.html Question: How is the What's New on MedlinePlus page and RSS feed different from ... this page, please enable JavaScript. Answer: The What's New on MedlinePlus page and RSS feed include alerts ...

  4. MedlinePlus E-mail Updates | NIH MedlinePlus the Magazine

    MedlinePLUS

    ... of this page please turn Javascript on. MedlinePlus E-mail Updates Past Issues / Spring - Summer 2010 Table ... in health and medicine? Sign up for MedlinePlus e-mail updates, and you'll receive alerts whenever ...

  5. Poor Reliability between Cochrane Reviewers and Blinded External Reviewers When Applying the Cochrane Risk of Bias Tool in Physical Therapy Trials

    PubMed Central

    Armijo-Olivo, Susan; Ospina, Maria; da Costa, Bruno R.; Egger, Matthias; Saltaji, Humam; Fuentes, Jorge; Ha, Christine; Cummings, Greta G.

    2014-01-01

    Objectives To test the inter-rater reliability of the RoB tool applied to Physical Therapy (PT) trials by comparing ratings from Cochrane review authors with those of blinded external reviewers. Methods Randomized controlled trials (RCTs) in PT were identified by searching the Cochrane Database of Systematic Reviews for meta-analysis of PT interventions. RoB assessments were conducted independently by 2 reviewers blinded to the RoB ratings reported in the Cochrane reviews. Data on RoB assessments from Cochrane reviews and other characteristics of reviews and trials were extracted. Consensus assessments between the two reviewers were then compared with the RoB ratings from the Cochrane reviews. Agreement between Cochrane and blinded external reviewers was assessed using weighted kappa (?). Results In total, 109 trials included in 17 Cochrane reviews were assessed. Inter-rater reliability on the overall RoB assessment between Cochrane review authors and blinded external reviewers was poor (? ?=? 0.02, 95%CI: ?0.06, 0.06]). Inter-rater reliability on individual domains of the RoB tool was poor (median ? ?=?0.19), ranging from ? ?=? ?0.04 (“Other bias”) to ? ?=? 0.62 (“Sequence generation”). There was also no agreement (? ?=? ?0.29, 95%CI: ?0.81, 0.35]) in the overall RoB assessment at the meta-analysis level. Conclusions Risk of bias assessments of RCTs using the RoB tool are not consistent across different research groups. Poor agreement was not only demonstrated at the trial level but also at the meta-analysis level. Results have implications for decision making since different recommendations can be reached depending on the group analyzing the evidence. Improved guidelines to consistently apply the RoB tool and revisions to the tool for different health areas are needed. PMID:24824199

  6. Finding translational science publications in MEDLINE/PubMed with translational science filters.

    PubMed

    Fontelo, Paul; Liu, Fang

    2011-12-01

    Translational Science Search (TSS; http://tscience.nlm.nih.gov) is a web application for finding MEDLINE/PubMed journal articles that are regarded by their authors as novel, promising, or may have potential clinical application. A set of "translational" filters and related terms was created by reviewing journal articles published in clinical and translational science (TS) journals. Through E-Utilities, a user's query and TS filters are submitted to PubMed, and then, the retrieved PubMed citations are matched with a database of MeSH terms (for disease conditions) and RxNorm (for interventions) to locate the search term, translational filters found, and associated interventions in the title and abstract. An algorithm ranks the interventions and conditions, and then highlights them in the results page for quick reading and evaluation. Using previously searched terms and standard formulas, the precision and recall of TSS were 0.99 and 0.47, compared to 0.58 and 1.0 for PubMed Entrez, respectively. PMID:22212228

  7. An active visual search interface for Medline.

    PubMed

    Xuan, Weijian; Dai, Manhong; Mirel, Barbara; Wilson, Justin; Athey, Brian; Watson, Stanley J; Meng, Fan

    2007-01-01

    Searching the Medline database is almost a daily necessity for many biomedical researchers. However, available Medline search solutions are mainly designed for the quick retrieval of a small set of most relevant documents. Because of this search model, they are not suitable for the large-scale exploration of literature and the underlying biomedical conceptual relationships, which are common tasks in the age of high throughput experimental data analysis and cross-discipline research. We try to develop a new Medline exploration approach by incorporating interactive visualization together with powerful grouping, summary, sorting and active external content retrieval functions. Our solution, PubViz, is based on the FLEX platform designed for interactive web applications and its prototype is publicly available at: http://brainarray.mbni.med.umich.edu/Brainarray/DataMining/PubViz. PMID:17951838

  8. CoPub Mapper: mining MEDLINE based on search term co-publication

    PubMed Central

    Alako, Blaise TF; Veldhoven, Antoine; van Baal, Sjozef; Jelier, Rob; Verhoeven, Stefan; Rullmann, Ton; Polman, Jan; Jenster, Guido

    2005-01-01

    Background High throughput microarray analyses result in many differentially expressed genes that are potentially responsible for the biological process of interest. In order to identify biological similarities between genes, publications from MEDLINE were identified in which pairs of gene names and combinations of gene name with specific keywords were co-mentioned. Results MEDLINE search strings for 15,621 known genes and 3,731 keywords were generated and validated. PubMed IDs were retrieved from MEDLINE and relative probability of co-occurrences of all gene-gene and gene-keyword pairs determined. To assess gene clustering according to literature co-publication, 150 genes consisting of 8 sets with known connections (same pathway, same protein complex, or same cellular localization, etc.) were run through the program. Receiver operator characteristics (ROC) analyses showed that most gene sets were clustered much better than expected by random chance. To test grouping of genes from real microarray data, 221 differentially expressed genes from a microarray experiment were analyzed with CoPub Mapper, which resulted in several relevant clusters of genes with biological process and disease keywords. In addition, all genes versus keywords were hierarchical clustered to reveal a complete grouping of published genes based on co-occurrence. Conclusion The CoPub Mapper program allows for quick and versatile querying of co-published genes and keywords and can be successfully used to cluster predefined groups of genes and microarray data. PMID:15760478

  9. LINK CONCORDANCE AND HIGHER-ORDER BLANCHFIELD DUALITY TIM D. COCHRAN, SHELLY HARVEY, CONSTANCE LEIDY

    E-print Network

    Leidy, Constance

    LINK CONCORDANCE AND HIGHER-ORDER BLANCHFIELD DUALITY TIM D. COCHRAN, SHELLY HARVEY, CONSTANCE Bing-double) of K is topologically slice then the integral over the circle of the Levine signatures then K is 1 #12;2 TIM D. COCHRAN, SHELLY HARVEY, CONSTANCE LEIDY K = BD(K) Figure 1.1. Bing double of K

  10. DERIVATIVES OF KNOTS AND SECOND-ORDER SIGNATURES TIM D. COCHRAN

    E-print Network

    Leidy, Constance

    DERIVATIVES OF KNOTS AND SECOND-ORDER SIGNATURES TIM D. COCHRAN , SHELLY HARVEY , AND CONSTANCE admit distinct smooth structures. In the 1960's Murasugi, Tristram, Levine and Milnor defined what we-DMS-0805867 . 1 #12;2 TIM D. COCHRAN, SHELLY HARVEY, AND CONSTANCE LEIDY exist precisely two homologically

  11. Reconsidering the Teacher Education Reform Debate: A Commentary on Cochran-Smith and Fries

    Microsoft Academic Search

    Gary D Fenstermacher

    2002-01-01

    In the November 2001 issue of Educational Researcher, Marilyn Cochran-Smith and Mary Kim Fries provided a penetrating analysis of the discourse that comprises the debate between those who advocate highly professionalized teacher preparation and those who seek simpler and more abundant routes to teacher training and certification. This commentary extends the Cochran-Smith and Fries analysis in several directions, inquiring into

  12. Research synthesis and dissemination as a bridge to knowledge management: the Cochrane Collaboration.

    PubMed Central

    Volmink, Jimmy; Siegfried, Nandi; Robertson, Katharine; Gülmezoglu, A. Metin

    2004-01-01

    In the current information age, research synthesis is a particularly useful tool for keeping track of scientific research and making sense of the large volumes of frequently conflicting data derived from primary studies. The Cochrane Collaboration is a global initiative "to help people make well-informed decisions about health care by preparing, maintaining and promoting the accessibility of systematic reviews of the effects of healthcare interventions". In this paper we set the work of the Cochrane Collaboration in historical perspective, explain what a Cochrane review is, and describe initiatives for promoting worldwide dissemination of synthesized information. We also consider emerging evidence of the Cochrane Collaboration's impact on health-care practice, policy, research and education. Finally, we highlight the need for increased investment in the preparation and maintenance of Cochrane reviews, particularly those that address health issues that are relevant to people living in low- and middle-income countries. PMID:15643800

  13. Development and classification of an operational definition of complementary and alternative medicine for the Cochrane Collaboration

    PubMed Central

    Wieland, L. Susan; Manheimer, Eric; Berman, Brian M.

    2011-01-01

    Over the past decade the Cochrane Collaboration has been an increasingly important source of information on complementary and alternative medicine (CAM) therapies. From 2007 to 2008 the Cochrane CAM Field developed a topics list that allowed us to categorize all 396 Cochrane reviews related to CAM (as of The Cochrane Library, Issue 4, 2009). This topics list is an advance in making Cochrane reviews on CAM topics accessible to the public. In this paper, we discuss challenges in developing the topics list, including developing an operational definition of CAM, deciding which reviews should be included within the CAM Field’s scope, developing the structured list of CAM Field-specific topics, and determining where in the topics list the reviews should be placed. Although aspects of our operational definition of CAM are open to revision, a standardized definition provides us with an objective, reproducible and systematic method for defining and classifying CAM therapies. PMID:21717826

  14. MedlinePlus.gov Turns 10!

    MedlinePLUS

    ... Spencer, NIH NIH's MedlinePlus.gov , the popular, consumer-friendly health Web site produced by the National Library of Medicine, is celebrating 10 years of bringing trusted health information to people across the country and around the world. What ...

  15. End User Searching of Medline. Final Report.

    ERIC Educational Resources Information Center

    Wildemuth, Barbara M.; Moore, Margaret E.

    One hundred sixty-one MEDLINE searches conducted by third year medical students were analyzed and evaluated to determine which search behaviors were used, whether those individual moves are effective, and whether there is a relationship between specific search behaviors and the effectiveness of the search strategy as a whole. The typical search…

  16. Literature in MEDLINE. . . A Bibliographic Anomaly?

    ERIC Educational Resources Information Center

    Robbins, Simone B.

    1985-01-01

    Discusses the inclusion of citations to literary articles that have appeared in medical journals in National Library of Medicine's database, MEDLINE. Highlights include search aids, search strategies, sample references, and five publications that serve as orientations to current status of movement toward interdisciplinary study of medicine and…

  17. Open Biomedical Ontology-based Medline exploration

    PubMed Central

    Xuan, Weijian; Dai, Manhong; Mirel, Barbara; Song, Jean; Athey, Brian; Watson, Stanley J; Meng, Fan

    2009-01-01

    Background Effective Medline database exploration is critical for the understanding of high throughput experimental results and the development of novel hypotheses about the mechanisms underlying the targeted biological processes. While existing solutions enhance Medline exploration through different approaches such as document clustering, network presentations of underlying conceptual relationships and the mapping of search results to MeSH and Gene Ontology trees, we believe the use of multiple ontologies from the Open Biomedical Ontology can greatly help researchers to explore literature from different perspectives as well as to quickly locate the most relevant Medline records for further investigation. Results We developed an ontology-based interactive Medline exploration solution called PubOnto to enable the interactive exploration and filtering of search results through the use of multiple ontologies from the OBO foundry. The PubOnto program is a rich internet application based on the FLEX platform. It contains a number of interactive tools, visualization capabilities, an open service architecture, and a customizable user interface. It is freely accessible at: . PMID:19426463

  18. MedlinePlus FAQ: How Often MedlinePlus is Updated

    MedlinePLUS

    ... this page, please enable JavaScript. Answer: MedlinePlus health topics pages: Reviewed continuously. We add new links every day. ... two dates in the footer of every health topic page: "Date last updated" indicates when information was added ...

  19. MedlinePlus FAQ: Will MedlinePlus work on my mobile device?

    MedlinePLUS

    ... mobile.html Question: Will MedlinePlus work on my mobile device? To use the sharing features on this page, ... Some video content might not play on your mobile device. See our FAQ on playing videos on phones ...

  20. Medline-based bibliometric analysis of gastroenterology journals between 2001 and 2007

    PubMed Central

    Chou, Li-Fang

    2009-01-01

    AIM: To analyze the MEDLINE-indexed publications in gastroenterology specialty journals from 2001 to 2007. Special attention was paid to specific types of articles, the number of publications for individual authors and the author count in each journal. METHODS: The bibliographic entries of papers belonging to journals listed under the subject heading of “gastroenterology” were downloaded from MEDLINE on the PubMed web site. The analysis was limited to journal articles published between January 1, 2001 and December 31, 2007. The analytical dimensions of an article included journal, publication year, publication type, and author name (the last name and initials). RESULTS: According to MEDLINE, 81 561 articles were published in 91 gastroenterology journals from 2001 to 2007. The number of articles increased from 9447 in 2001 to 13 340 in 2007. Only 12 journals had more than 2000 articles indexed in MEDLINE. The “World Journal of Gastroenterology” had the largest number of publications (5684 articles), followed by “Hepato-Gastroenterology” (3036) and “Gastrointestinal Endoscopy” (3005). Of all the articles published, reviews accounted for 17.2% and case reports for 15.4%. Only 3739 randomized controlled trials (4.6% of all articles) were published and their annual number increased from 442 in 2001 to 572 in 2007. Among 141 741 author names appearing in the articles of gastroenterology journals, 92 429 had published only in one journal, 22 585 in two journals, 9996 in three journals, and 16 731 in more than three journals. The “World Journal of Gastroenterology” had the greatest number of authors (17 838), followed by “Gastroenterology” (12 770), “Digestive Diseases and Sciences” (11 395), “American Journal of Gastroenterology” (10 889), and “Hepatology” (10 588). CONCLUSION: Global gastroenterology publications displayed a continuous growth in the new millennium. The change was most striking in certain journals. Regular bibliometric analyses on the trends and specific topics would help researchers publish more efficiently and allow editors to adjust the policy more accurately. PMID:19533822

  1. Contributing to the growth of Physical and Rehabilitation Medicine (PRM): call for a Cochrane Field in PRM.

    PubMed

    Negrini, S; Kiekens, C; Meerpohl, J J; Thomson, D; Zampolini, M; Christodoulou, N; Delarque, A; Gutenbrunner, C; Michail, X

    2015-06-01

    The European Society of Physical and Rehabilitation Medicine (ESPRM), together with the European Journal of PRM and the PRM Section and Board of the European Union of Medical Specialists (UEMS), started an action to establish a relationship with Cochrane (formerly the Cochrane Collaboration). Cochrane is a global, independent network of researchers, professionals, patients, carers and people interested in health, with contributors from more than 130 countries. Its aim is to produce credible, accessible health information that is free from any conflicts of interest. Cochrane produces the Cochrane Library, an evidence-based resource that includes today more than 6300 Cochrane systematic reviews. Cochrane is made up of many different review groups and other entities (such as Centres and Branches), distributed around the world, that are mainly focused on specific healthcare problems (diseases, or organs). Inside Cochrane also Fields have been created, that focus on a dimension of health care other than a specific healthcare problem. A Cochrane Field represents a bridge between Cochrane and the stakeholders of the related healthcare area. The medical specialty of PRM is covering a broad medical domain: it deals with function, activities and participation in a large number of health conditions, mostly but not exclusively musculoskeletal, neurological and cardiorespiratory. Consequently, the currently more than 200 existing Cochrane Reviews are scattered among different groups. A PRM Field could greatly serve to the need of the specialty, spreading the actual Cochrane knowledge, focusing needs today not covered by Cochrane Reviews, facing the intrinsic methodological problems of the specialty. This paper introduces a call for the development of a PRM Cochrane Field, briefly reviewing what Cochrane is and how it is organized, defining the value and identifying a pathway toward the development of a PRM Cochrane Field, and finally shortly reviewing the Cochrane reviews of PRM interest. PMID:25986225

  2. Telerehabilitation for persons with multiple sclerosis. A Cochrane review.

    PubMed

    Khan, F; Amatya, B; Kesselring, J; Galea, M P

    2015-06-01

    A wide range of telerehabilitation interventions are trialled in persons with multiple sclerosis (pwMS). However, the evidence for their effectiveness is unclear. Aim of the review was to systematically assess the effectiveness and safety of telerehabilitation intervention in pwMS, the types of approaches that are effective (setting, type, intensity) and the outcomes (impairment, activity limitation and participation) that are affected. The search strategy comprised: Cochrane Multiple Sclerosis and Rare Diseases of the Central Nervous System Review Group Specialised Register (up to 9 July, 2014). Relevant journals and reference lists of identified studies were screened for additional data. Selected studies included randomized and controlled clinical trials that compared telerehabilitation intervention/s in pwMS with a control intervention (such as lower level or different types of intervention, minimal intervention; waiting-list controls, no treatment or usual care; interventions given in different settings). Best evidence synthesis was based on methodological quality using the GRADEpro software. Nine RCTs (N.=531 participants, 469 included in analyses) investigated a variety of telerehabilitation interventions in adults with MS. The interventions evaluated were complex, with more than one rehabilitation component and included physical activity, educational, behavioural and symptom management programmes. All studies scored "low" on the methodological quality assessment. Evidence from included studies provides 'low-level' evidence for reduction in short-term disability (and symptoms) such as fatigue. There was also "low-level" evidence supporting telerehabilitation in the longer term for improved functional activities, impairments (such as fatigue, pain, insomnia); and participation. There were limited data on process evaluation (participants'/therapists' satisfaction) and no data available for cost effectiveness. There were no adverse events reported as a result of telerehabilitation intervention. There is limited evidence to date, on the efficacy of telerehabilitation in improving functional activities, fatigue and quality of life in adults with MS. There is also insufficient evidence to support what types of telerehabilitation interventions are effective, and in which setting. More robust trials are needed to build evidence for the clinical and cost effectiveness of these interventions. PMID:25943744

  3. MedlinePlus FAQ: Listing Your Web Site

    MedlinePLUS

    ... gov/medlineplus/faq/criteria.html Question: How do Web sites get listed in MedlinePlus? To use the ... authoritative resources. MedlinePlus uses quality guidelines to evaluate Web sites. We try to ensure that the information ...

  4. 28. W. W. Cochran, M. Wikelski, in Birds of Two Worlds, P. Marra, R. Greenberg, Eds. (Johns Hopkins Press, Baltimore,

    E-print Network

    Falkowski, Paul G.

    measurements and thank M. Bowlin, N. Sapir, A. Medina, W. Cochran, J. Cochran, J. Mandel, and S. David dioxide (pCO2) in the atmosphere. Because rates of photosynthesis and biological carbon export are low

  5. Extracting noun phrases for all of MEDLINE.

    PubMed Central

    Bennett, N. A.; He, Q.; Powell, K.; Schatz, B. R.

    1999-01-01

    A natural language parser that could extract noun phrases for all medical texts would be of great utility in analyzing content for information retrieval. We discuss the extraction of noun phrases from MEDLINE, using a general parser not tuned specifically for any medical domain. The noun phrase extractor is made up of three modules: tokenization; part-of-speech tagging; noun phrase identification. Using our program, we extracted noun phrases from the entire MEDLINE collection, encompassing 9.3 million abstracts. Over 270 million noun phrases were generated, of which 45 million were unique. The quality of these phrases was evaluated by examining all phrases from a sample collection of abstracts. The precision and recall of the phrases from our general parser compared favorably with those from three other parsers we had previously evaluated. We are continuing to improve our parser and evaluate our claim that a generic parser can effectively extract all the different phrases across the entire medical literature. PMID:10566444

  6. Subscribe to NIH MedlinePlus the Magazine

    MedlinePLUS

    ... turn Javascript on. Subscribe to NIH MedlinePlus the magazine NIH MedlinePlus the magazine is published quarterly, in print and on the ... up for a free subscription to NIH MedlinePlus Magazine. Librarians may order this magazine in bulk . Please ...

  7. MedlinePlus Goes Local in NC

    Microsoft Academic Search

    Carol G. Jenkins; Joanne Gard Marshall; Diana McDuffee

    2004-01-01

    NC Health Info http:\\/\\/www.nchealthinfo.orgis a collection of online North Carolina-based health services Web sites that link seamlessly with health information on MedlinePlus, the National Library of Medicine's Web site. NC Health Info is the result of a pilot study to define the components involved in creating such a system and serves as a model to be used by other states

  8. MEDLINE: the options for health professionals.

    PubMed Central

    Wood, E H

    1994-01-01

    The bibliographic database MEDLINE, produced by the National Library of Medicine (NLM), is a computerized index to the world's biomedical literature. The database can be searched back to 1966 and contains 6.8 million records. The various means of access are divided, for the purposes of this article, into three categories: logging onto a remote host computer by telephone and modem or by the Internet; subscribing to part or all of the database on compact disc (CD-ROM); and leasing the data on a transport medium such as magnetic tape or CDs for loading on a local host computer. Decisions about which method is preferable in a given situation depend on cost, availability of hardware and software, local expertise, and the size of the intended user population. Trends include increased access to the Internet by health professionals, increased network speed, links from MEDLINE records to full-text databases or online journals, and integration of MEDLINE into wider health information systems. PMID:7850561

  9. PEDro or Cochrane to Assess the Quality of Clinical Trials? A Meta-Epidemiological Study

    PubMed Central

    Armijo-Olivo, Susan; da Costa, Bruno R.; Cummings, Greta G.; Ha, Christine; Fuentes, Jorge; Saltaji, Humam; Egger, Matthias

    2015-01-01

    Objective There is debate on how the methodological quality of clinical trials should be assessed. We compared trials of physical therapy (PT) judged to be of adequate quality based on summary scores from the Physiotherapy Evidence Database (PEDro) scale with trials judged to be of adequate quality by Cochrane Risk of Bias criteria. Design Meta-epidemiological study within Cochrane Database of Systematic Reviews. Methods Meta-analyses of PT trials were identified in the Cochrane Database of Systematic Reviews. For each trial PeDro and Cochrane assessments were extracted from the PeDro and Cochrane databases. Adequate quality was defined as adequate generation of random sequence, concealment of allocation, and blinding of outcome assessors (Cochrane criteria) or as trials with a PEDro summary score ?5 or ?6 points. We combined trials of adequate quality using random-effects meta-analysis. Results Forty-one Cochrane reviews and 353 PT trials were included. All meta-analyses included trials with PEDro scores ?5, 37 (90.2%) included trials with PEDro scores ?6 and only 22 (53.7%) meta-analyses included trials of adequate quality according to the Cochrane criteria. Agreement between PeDro and Cochrane was poor for PeDro scores of ?5 points (kappa = 0.12; 95% CI 0.07 to 0.16) and slight for ?6 points (kappa 0.24; 95% CI 0.16-0.32). When combining effect sizes of trials deemed to be of adequate quality according to PEDro or Cochrane criteria, we found that a substantial difference in the combined effect size (?0.15) was evident in 9 (22%) out of the 41 meta-analyses for PEDro cutoff ?5 and 10 (24%) for cutoff ?6. Conclusions The PeDro and Cochrane approaches lead to different sets of trials of adequate quality, and different combined treatment estimates from meta-analyses of these trials. A consistent approach to assessing RoB in trials of physical therapy should be adopted. PMID:26161653

  10. Impact of Including Korean Randomized Controlled Trials in Cochrane Reviews of Acupuncture

    PubMed Central

    Kim, Kun Hyung; Kong, Jae Cheol; Choi, Jun-Yong; Choi, Tae-Young; Shin, Byung-Cheul; McDonald, Steve; Lee, Myeong Soo

    2012-01-01

    Objective Acupuncture is commonly practiced in Korea and is regularly evaluated in clinical trials. Although many Cochrane reviews of acupuncture include searches of both English and Chinese databases, there is no information on the value of searching Korean databases. This study aimed to investigate the impact of searching Korean databasesand journals for trials eligible for inclusion in existing Cochrane acupuncture reviews. Methods We searched 12 Korean databases and seven Korean journals to identify randomised trials meeting the inclusion criteria for acupuncture reviews in the Cochrane Database of Systematic Reviews. We compared risk of bias assessments of the Korean trials with the trials included in the Cochrane acupuncture reviews. Where possible, we added data from the Korean trials to the existing meta-analyses in the relevant Cochrane review and conducted sensitivity analyses to test the robustness of the results. Results Sixteen Korean trials (742 participants) met the inclusion criteria for eight Cochrane acupuncture reviews (125 trials; 13,041 participants). Inclusion of the Korean trials provided data for 20% of existing meta-analyses (24 out of 120). Inclusion of the Korean trials did not change the direction of effect in any of the existing meta-analyses. The effect size and heterogeneity remained mostly unchanged. In only one meta-analysis did the significance change. Compared to the studies included in the Cochrane acupuncture reviews, the risk of bias in the Korean trials was higher in terms of outcome assessor blinding and allocation concealment. Conclusions Many Korean studies contributed additional data to the existing meta-analyses in Cochrane acupuncture reviews. Although inclusion of these studies did not alter the results of the meta-analyses, comprehensive searches of the literature are important to avoid potential language bias. The identification and inclusion of eligible Korean trials should be considered for reviews of acupuncture. PMID:23071826

  11. MedlinePlus 2010 User Survey Results: How did you learn of the MedlinePlus web site?

    MedlinePLUS

    ... Next How did you learn of the MedlinePlus web site? (MedlinePlus en español users only) To use ... features on this page, please enable JavaScript. Responses: Web search engine (Yahoo!, Google, AOL, etc.) MedlinePlus en ...

  12. Benchmarking the dental implant evidence on MEDLINE.

    PubMed

    Russo, S P; Fiorellini, J P; Weber, H P; Niederman, R

    2000-01-01

    The purpose of this study was to estimate the quantity of dental implant literature available on MEDLINE for evidence-based clinical decision-making and to identify its location. A search strategy based on Medical Subject Headings for dental implants was developed to examine MEDLINE using the Ovid Web Gateway search engine. Sensitive and specific methodologic search filters identified 4 categories of information: etiology, diagnosis, therapy, and prognosis. The results were then subdivided by year to identify trends and sorted to identify the sources of publications. The searches identified 4,655 articles published in English between 1989 and 1999 on human dental implants on MEDLINE. The mean number of articles (+/- SD) per year ranged from 15 +/- 11 for specific searches to 107 +/- 50 for sensitive searches. The number of articles increased by 14% to 43% each year for the sensitive search. When subdivided by clinical category, the mean numbers of articles per year for sensitive and specific searches were, respectively: diagnosis 12 +/- 7.5 and 1.5 +/- 1.6, etiology 58 +/- 33 and 1.9 +/- 2.5, therapy 23 +/- 15 and 0.3 +/- 0.5, and prognosis 67 +/- 33 and 12 +/- 8.3. Four dental journals account for approximately half of these publications. These results provide 6 key central findings: (1) there appears to be a substantial literature of clinically relevant information on implants upon which to base clinical decisions; (2) the implant literature is significantly biased toward articles addressing prognosis; (3) to stay current, one would need to read between 1 and 2 articles per week 52 weeks per year, and this number increases significantly each year; (4) approximately 50% of the articles were published in 4 journals, whereas the remainder reside in approximately 97 other journals, making it difficult to stay current; (5) these trends reaffirm the need for lifelong learning; (6) these trends also suggest the need for computer-based clinical knowledge systems. PMID:11151577

  13. MedlinePLUS: Interactive Health Tutorials

    NSDL National Science Digital Library

    This Web site from the National Library of Medicine's MedlinePLUS contains interactive health tutorials developed by the Patient Education Institute. The tutorials use easy-to-follow animations and narration to explain medical procedures and health conditions. Dozens and dozens of tutorials are available. Recent additions include tutorials on smallpox, hearing loss, bone densitometry, dust mite allergies, and many more. Users control the pace of the tutorial, and can test their understanding of the material at various points with short, interactive quizzes.

  14. Systematic reviews published in the July 2014 issue of the Cochrane Library.

    PubMed

    Wiffen, Philip J

    2014-12-01

    The Cochrane Library of Systematic Reviews is published quarterly as a DVD and monthly online ( http://www.thecochranelibrary.com ). The July 2014 issue (3rd DVD for 2014) contains 6050 complete reviews, 2,359 protocols for reviews in production, and 31,000 short summaries of systematic reviews published in the general medical literature. In addition, there are citations of 789,000 randomized controlled trials, and 15,700 cited papers in the Cochrane Methodology Register. The Health Technology Assessment database contains some 14,000 citations. Ninety-six new reviews have been published in the previous 3 months of which five have potential relevance for practitioners in pain and palliative medicine. The impact factor of the Cochrane Library stands at 5.715. Readers are encouraged to access the full report for any articles of interest as only a brief commentary is provided. PMID:25338103

  15. Systematic Reviews Published in the January 2015 Issue of the Cochrane Library.

    PubMed

    Wiffen, Philip J

    2015-06-01

    The Cochrane Library of Systematic Reviews is published quarterly as a DVD and monthly online ( http://www.thecochranelibrary.com ). The January 2015 issue (first DVD for 2015) contains 6277 complete reviews, 2355 protocols for reviews in production, and 34,000 short summaries of systematic reviews published in the general medical literature. In addition, there are citations of 832,000 randomized controlled trials, and 15,700 cited papers in the Cochrane Methodology Register. The Health Technology Assessment database contains some 14,000 citations. One hundred and ten new reviews have been published in the previous 3 months, of which six have potential relevance for practitioners in pain and palliative medicine. The impact factor of the Cochrane Library stands at 5.939. Readers are encouraged to access the full report for any articles of interest, as only a brief commentary is provided. PMID:26095497

  16. PubMed QUICK GUIDE University of California Berkeley Library Use this URL to access the UCcustomized version of PubMed, with links to UCBsubscribed full text

    E-print Network

    PubMed searching is easy: just enter terms in the search box and click Search. The Advanced Search link below the search box provides access to additional searching options. Keyword Searching Enter combines (ANDs) significant terms together using automatic term mapping, matching your search terms

  17. Ideology and Reform in Teacher Education in England: Some Reflections on Cochran-Smith and Fries.

    ERIC Educational Resources Information Center

    Furlong, John

    2002-01-01

    Presents an international perspective on Cochran-Smith and Fries' recent analysis of the ways that two competing ideologies (deregulation and professionalization) are being employed in the United States to support teacher education reform, noting important differences between the United States and England in how these ideologies have been advanced…

  18. Ideology and Reform in Teacher Education in England: Some Reflections on Cochran-Smith and Fries

    Microsoft Academic Search

    John Furlong

    2002-01-01

    This article presents an international perspective on Cochran-Smith and Fries’ (2001) recent analysis of the ways in which two competing ideologies are currently being employed in the United States in support of teacher education reform. In England over the last 15 years, teacher education has been fundamentally reformed and the arguments of both the “deregulators” and the “professionalizers” have been

  19. The updated Cochrane review 2014 on GnRH agonist trigger: repeating the same errors.

    PubMed

    Kol, Shahar; Humaidan, Peter; Alsbjerg, Birgit; Engmann, Lawrence; Benadiva, Claudio; García-Velasco, Juan A; Fatemi, Human; Andersen, Claus Yding

    2015-06-01

    Cochrane reviews are powerful tools, internationally recognized as the highest standard in evidence-based health care. A Cochrane analysis makes use of precise, reproducible criteria in the selection of studies for review. In the context of a previous Cochrane review (2010) on the subject of gonadotrophin-releasing hormone agonist (GnRHa) trigger, we questioned whether a review should be conducted during the research phase when new concepts are being developed. Recently, an updated Cochrane review was published, reaching the same general conclusion as the first one, i.e., GnRHa triggers lower the chance of pregnancy in fresh autologous IVF and intracytoplasmic injection treatment cycles. We argue that the new review repeats previous errors by compiling data from studies that were not comparable as different luteal phase protocols were used. From the clinical point of view, the luteal support used is the variable which affects the pregnancy rate and not the use of the GnRHa trigger for final oocyte maturation. Therefore, a meaningful comparison between GnRHa and HCG trigger must be confined to outcome measures that are not affected by the luteal support used. We conclude that the updated review falls short of addressing meaningful clinical and fundamental questions in the context of GnRHa trigger. PMID:25892499

  20. Fractal Volume Compression Wayne O. Cochran John C. Hart Patrick J. Flynn

    E-print Network

    Fractal Volume Compression Wayne O. Cochran John C. Hart Patrick J. Flynn School of Electrical@eecs.wsu.edu October 18, 1995 Abstract This research is the rst application of fractal compression to volumetric data. The various components of the fractal image compression method extend simply and di- rectly to the volumetric

  1. Porosity distribution in San Andres Formation (Permian), Cochran and Hockley Counties, Texas

    Microsoft Academic Search

    P. E. Cowan; P. M. Harris

    1986-01-01

    The lower San Andres Formation in Cochran and Hockley Counties, Texas, is one of the most prolific hydrocarbon-bearing horizons of the Permian basin. It is a cyclic sequence of shallow-water carbonates and evaporites which prograded across the northwest shelf toward the Midland and Delaware basins. San Andres production results from the vertical stacking of porous dolomite reservoirs. Stratigraphic trapping of

  2. Metformin versus oral contraceptive pill in polycystic ovary syndrome: a Cochrane review

    Microsoft Academic Search

    Michael F. Costello; Bhushan Shrestha; John Eden; Neil P. Johnson; Peter Sjoblom

    2007-01-01

    BACKGROUND: The object of this review was to compare metformin versus oral contraceptive pill (OCP) treatment in polycystic ovary syndrome. METHODS: A systematic review and meta-analysis employing the principles of the Cochrane Menstrual Disorders and Subfertility Group was undertaken. RESULTS: Four randomized controlled trials (RCTs) (104 subjects) were included. Limited data demonstrated no evidence of a difference in effect between

  3. Development of a heart failure filter for Medline: an objective approach using evidence-based clinical practice guidelines as an alternative to hand searching

    PubMed Central

    2011-01-01

    Background Heart failure is a highly debilitating syndrome with a poor prognosis primarily affecting the elderly. Clinicians wanting timely access to heart failure evidence to provide optimal patient care can face many challenges in locating this evidence. This study developed and validated a search filter of high clinical utility for the retrieval of heart failure articles in OvidSP Medline. Methods A Clinical Advisory Group was established to advise study investigators. The study set of 876 relevant articles from four heart failure clinical practice guidelines was divided into three datasets: a Term Identification Set, a Filter Development Set, and a Filter Validation Set. A further validation set (the Cochrane Validation Set) was formed using studies included in Cochrane heart failure systematic reviews. Candidate search terms were identified via word frequency analysis. The filter was developed by creating combinations of terms and recording their performance in retrieving items from the Filter Development Set. The filter's recall was then validated in both the Filter Validation Set and the Cochrane Validation Set. A precision estimate was obtained post-hoc by running the filter in Medline and screening the first 200 retrievals for relevance to heart failure. Results The four-term filter achieved a recall of 96.9% in the Filter Development Set; 98.2% in the Filter Validation Set; and 97.8% in the Cochrane Validation Set. Of the first 200 references retrieved by the filter when run in Medline, 150 were deemed relevant and 50 irrelevant. The post-hoc precision estimate was therefore 75%. Conclusions This study describes an objective method for developing a validated heart failure filter of high recall performance and then testing its precision post-hoc. Clinical practice guidelines were found to be a feasible alternative to hand searching in creating a gold standard for filter development. Guidelines may be especially appropriate given their clinical utility. A validated heart failure filter is now available to support health professionals seeking reliable and efficient access to the heart failure literature. PMID:21272371

  4. Improving accuracy for identifying related PubMed queries by an integrated approach

    PubMed Central

    Lu, Zhiyong; Wilbur, W. John

    2009-01-01

    PubMed is the most widely used tool for searching biomedical literature online. As with many other online search tools, a user often types a series of multiple related queries before retrieving satisfactory results to fulfill a single information need. Meanwhile, it is also a common phenomenon to see a user type queries on unrelated topics in a single session. In order to study PubMed users’ search strategies, it is necessary to be able to automatically separate unrelated queries and group together related queries. Here, we report a novel approach combining both lexical and contextual analyses for segmenting PubMed query sessions and identifying related queries and compare its performance with the previous approach based solely on concept mapping. We experimented with our integrated approach on sample data consisting of 1,539 pairs of consecutive user queries in 351 user sessions. The prediction results of 1,396 pairs agreed with the gold-standard annotations, achieving an overall accuracy of 90.7%. This demonstrates that our approach is significantly better than the previously published method. By applying this approach to a one day query log of PubMed, we found that a significant proportion of information needs involved more than one PubMed query, and that most of the consecutive queries for the same information need are lexically related. Finally, the proposed PubMed distance is shown to be an accurate and meaningful measure for determining the contextual similarity between biological terms. The integrated approach can play a critical role in handling real-world PubMed query log data as is demonstrated in our experiments. PMID:19162232

  5. Saving the Time of the Library User through Subject Access Innovation: Papers in Honor of Pauline Atherton Cochrane.

    ERIC Educational Resources Information Center

    Wheeler, William J., Ed.

    This book contains the following papers in honor of Pauline Atherton Cochrane on subject access issues in library and information science: (1) "Obstacles in Progress in Mechanized Subject Access and the Necessity of a Paradigm Change" (Robert Fugmann); (2) "On MARC and the Nature of Text Searching: A Review of Pauline Cochrane's Inspirational…

  6. 77 FR 65545 - Mr. Jesse S. Capel and Mr. Hilton J. Cochran; EWP LLC; Notice of Transfer of Exemption

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-29

    ...Energy Regulatory Commission [Project No. 4815-009] Mr. Jesse S. Capel and Mr. Hilton J. Cochran; EWP LLC; Notice of...on July 30, 2012 and supplemented on August 14, 2012, Mr. Jesse S. Capel and Mr. Hilton J. Cochran and EWP LLC informed...

  7. Finding Good Health Information on the Internet | NIH MedlinePlus the Magazine

    MedlinePLUS

    ... page please turn JavaScript on. Feature: MedlinePlus Advantage The MedlinePlus Advantage Past Issues / Winter 2015 Table of Contents MedlinePlus is the National Institutes of Health's website for patients and ...

  8. PURE: a PubMed article recommendation system based on content-based filtering.

    PubMed

    Yoneya, Takashi; Mamitsuka, Hiroshi

    2007-01-01

    We have developed a PubMed article recommendation system, PURE, which is based on content-based filtering. PURE has a web interface by which users can add/delete their preferred articles. Once articles are registered, PURE then performs model-based clustering of the preferred articles and recommends the highly-rated articles by the prediction using the trained model. PURE updates the PubMed articles and reports the recommendation by email on daily-base. This system will be helpful for biologists to reduce the time required for gathering information from PubMed. PURE is downloadable under GPL license, via www.bic.kyoto-u.ac.jp/pathway/mami/out/PURE.tar.gz. PMID:18546494

  9. An automatic method to generate domain-specific investigator networks using PubMed abstracts

    PubMed Central

    Yu, Wei; Yesupriya, Ajay; Wulf, Anja; Qu, Junfeng; Gwinn, Marta; Khoury, Muin J

    2007-01-01

    Background Collaboration among investigators has become critical to scientific research. This includes ad hoc collaboration established through personal contacts as well as formal consortia established by funding agencies. Continued growth in online resources for scientific research and communication has promoted the development of highly networked research communities. Extending these networks globally requires identifying additional investigators in a given domain, profiling their research interests, and collecting current contact information. We present a novel strategy for building investigator networks dynamically and producing detailed investigator profiles using data available in PubMed abstracts. Results We developed a novel strategy to obtain detailed investigator information by automatically parsing the affiliation string in PubMed records. We illustrated the results by using a published literature database in human genome epidemiology (HuGE Pub Lit) as a test case. Our parsing strategy extracted country information from 92.1% of the affiliation strings in a random sample of PubMed records and in 97.0% of HuGE records, with accuracies of 94.0% and 91.0%, respectively. Institution information was parsed from 91.3% of the general PubMed records (accuracy 86.8%) and from 94.2% of HuGE PubMed records (accuracy 87.0). We demonstrated the application of our approach to dynamic creation of investigator networks by creating a prototype information system containing a large database of PubMed abstracts relevant to human genome epidemiology (HuGE Pub Lit), indexed using PubMed medical subject headings converted to Unified Medical Language System concepts. Our method was able to identify 70–90% of the investigators/collaborators in three different human genetics fields; it also successfully identified 9 of 10 genetics investigators within the PREBIC network, an existing preterm birth research network. Conclusion We successfully created a web-based prototype capable of creating domain-specific investigator networks based on an application that accurately generates detailed investigator profiles from PubMed abstracts combined with robust standard vocabularies. This approach could be used for other biomedical fields to efficiently establish domain-specific investigator networks. PMID:17584920

  10. Global priority setting for Cochrane systematic reviews of health promotion and public health research

    PubMed Central

    Doyle, J; Waters, E; Yach, D; McQueen, D; De Francisco, A; Stewart, T; Reddy, P; Gulmezoglu, A; Galea, G; Portela, A

    2005-01-01

    Background: Systematic reviews of health promotion and public health interventions are increasingly being conducted to assist public policy decision making. Many intra-country initiatives have been established to conduct systematic reviews in their relevant public health areas. The Cochrane Collaboration, an international organisation established to conduct and publish systematic reviews of healthcare interventions, is committed to high quality reviews that are regularly updated, published electronically, and meeting the needs of the consumers. Aims: To identify global priorities for Cochrane systematic reviews of public health topics. Methods: Systematic reviews of public health interventions were identified and mapped against global health risks. Global health organisations were engaged and nominated policy-urgent titles, evidence based selection criteria were applied to set priorities. Results: 26 priority systematic review titles were identified, addressing interventions such as community building activities, pre-natal and early infancy psychosocial outcomes, and improving the nutrition status of refugee and displaced populations. Discussion: The 26 priority titles provide an opportunity for potential reviewers and indeed, the Cochrane Collaboration as a whole, to address the previously unmet needs of global health policy and research agencies. PMID:15709077

  11. Down the Block... Around the World...MedlinePlus.gov

    MedlinePLUS

    ... Issue Past Issues Down the Block... Around the World...MedlinePlus.gov Past Issues / Spring 2008 Table of ... on. No matter where you are in the world, www.medlineplus.gov is your best global source ...

  12. Welcome to NIH MedlinePlus, the magazine

    MedlinePLUS

    ... MedlinePlus Web site. There is no advertising, no registration and the site is completely free. In addition ... books, journals, technical reports, manuscripts, microfilms, photographs and images. Housed within the Library is one of the ...

  13. Creating the First MedlinePlus “Go Local” Service

    Microsoft Academic Search

    Christie Silbajoris; Diana McDuffee; Cynthia Olney

    2007-01-01

    NC Health Info is an online collection of North Carolina-based health services Web sites that seamlessly links local health resources to topical health information on MedlinePlus, the National Library of Medicine's consumer health information Web site. NC Health Info was the first project to connect local resources with MedlinePlus in the “Go Local” initiative. As such, NC Health Info serves

  14. A usability study of the PubMed on Tap user interface for PDAs.

    PubMed

    Alexander, Gregory; Hauser, Susan; Steely, Karen; Ford, Glenn; Demner-Fushman, Dina

    2004-01-01

    Healthcare providers are challenged by the availability of information at the point of care. Overcoming these challenges requires access to current, reliable, and accurate information. The purpose of the PubMed on Tap project is to discover and implement design principles to facilitate healthcare practitioners' access to medical information at the point-of-care, related to user interface design, organization and performance. The PubMed on Tap prototype was developed for personal digital assistants (PDAs) as a testbed to study these design principles. Usability testing was used to derive conclusions regarding the functionality of PubMed on Tap. Participant events (n=323) mostly occurred in navigational ability (31%) and perceived functionality (33%). A strong correlation (r=0.87) was observed between total time and the sum of negative events in locating functions and navigational categories. Researchers concluded the basic functionality of the PubMed on Tap interface was valuable to users. However, there was room for improvement in the navigational and functional characteristics, such as placing labels on icons, which affected the users' ability to use the research tool. PMID:15361047

  15. Comparison of PubMed, Scopus, Web of Science, and Google Scholar: strengths and weaknesses

    Microsoft Academic Search

    Matthew E. Falagas; Eleni I. Pitsouni; George A. Malietzis; Georgios Pappas

    2007-01-01

    The evolution of the electronic age has led to the development of numerous medical databases on the World Wide Web, offering search facilities on a particular subject and the ability to perform citation analysis. We compared the content coverage and prac- tical utility of PubMed, Scopus, Web of Science, and Google Scholar. The official Web pages of the data- bases

  16. Chapter 9: PubMed Central (PMC): An Archive for Literature from Life Sciences Journals

    E-print Network

    Levin, Judith G.

    Chapter 9: PubMed Central (PMC): An Archive for Literature from Life Sciences Journals Jeff Beck Ed-text journal literature. Journals deposit material in PMC on a voluntary basis. Articles in PMC may be retrieved either by browsing a table of contents for a specific journal or by searching the database

  17. National Library of Medicine PubMed Central Back Issue Scanning Project

    E-print Network

    Levin, Judith G.

    National Library of Medicine PubMed Central Back Issue Scanning Project Image Specifications and Functional Requirements for Citation Capture Version 3.2 May, 2007 National Library of Medicine NationalMed Central Back Issue Scanning Specifications U.S. National Library of Medicine, 8600 Rockville Pike

  18. A SNPshot of PubMed to associate genetic variants with drugs, diseases, and adverse reactions

    E-print Network

    Baral, Chitta

    A SNPshot of PubMed to associate genetic variants with drugs, diseases, and adverse reactions Jörg, drug efficacy, and drug responses between individuals and sub-populations. Wrong dosages of drugs can lead to severe adverse drug reac- tions in individuals whose drug metabolism drastically differs from

  19. Improving links between literature and biological data with text mining: a case study with GEO, PDB and MEDLINE

    PubMed Central

    Névéol, Aurélie; Wilbur, W. John; Lu, Zhiyong

    2012-01-01

    High-throughput experiments and bioinformatics techniques are creating an exploding volume of data that are becoming overwhelming to keep track of for biologists and researchers who need to access, analyze and process existing data. Much of the available data are being deposited in specialized databases, such as the Gene Expression Omnibus (GEO) for microarrays or the Protein Data Bank (PDB) for protein structures and coordinates. Data sets are also being described by their authors in publications archived in literature databases such as MEDLINE and PubMed Central. Currently, the curation of links between biological databases and the literature mainly relies on manual labour, which makes it a time-consuming and daunting task. Herein, we analysed the current state of link curation between GEO, PDB and MEDLINE. We found that the link curation is heterogeneous depending on the sources and databases involved, and that overlap between sources is low, <50% for PDB and GEO. Furthermore, we showed that text-mining tools can automatically provide valuable evidence to help curators broaden the scope of articles and database entries that they review. As a result, we made recommendations to improve the coverage of curated links, as well as the consistency of information available from different databases while maintaining high-quality curation. Database URLs: http://www.ncbi.nlm.nih.gov/PubMed, http://www.ncbi.nlm.nih.gov/geo/, http://www.rcsb.org/pdb/ PMID:22685160

  20. How useful are systematic reviews for informing palliative care practice? Survey of 25 Cochrane systematic reviews

    PubMed Central

    Wee, Bee; Hadley, Gina; Derry, Sheena

    2008-01-01

    Background In contemporary medical research, randomised controlled trials are seen as the gold standard for establishing treatment effects where it is ethical and practical to conduct them. In palliative care such trials are often impractical, unethical, or extremely difficult, with multiple methodological problems. We review the utility of Cochrane reviews in informing palliative care practice. Methods Published reviews in palliative care registered with the Cochrane Pain, Palliative and Supportive Care Group as of December 2007 were obtained from the Cochrane Database of Systematic Reviews, issue 1, 2008. We reviewed the quality and quantity of primary studies available for each review, assessed the quality of the review process, and judged the strength of the evidence presented. There was no prior intention to perform any statistical analyses. Results 25 published systematic reviews were identified. Numbers of included trials ranged from none to 54. Within each review, included trials were heterogeneous with respect to patients, interventions, and outcomes, and the number of patients contributing to any single analysis was generally much lower than the total included in the review. A variety of tools were used to assess trial quality; seven reviews did not use this information to exclude low quality studies, weight analyses, or perform sensitivity analysis for effect of low quality. Authors indicated that there were frequently major problems with the primary studies, individually or in aggregate. Our judgment was that the reviewing process was generally good in these reviews, and that conclusions were limited by the number, size, quality and validity of the primary studies. We judged the evidence about 23 of the 25 interventions to be weak. Two reviews had stronger evidence, but with limitations due to methodological heterogeneity or definition of outcomes. No review provided strong evidence of no effect. Conclusion Cochrane reviews in palliative care are well performed, but fail to provide good evidence for clinical practice because the primary studies are few in number, small, clinically heterogeneous, and of poor quality and external validity. They are useful in highlighting the weakness of the evidence base and problems in performing trials in palliative care. PMID:18715496

  1. Challenges in integrating international evidence relating to stroke rehabilitation: experiences from a Cochrane systematic review.

    PubMed

    Pollock, Alex; Campbell, Pauline; Baer, Gillian; Choo, Pei Ling; Forster, Anne; Morris, Jacqui; Pomeroy, Valerie M; Langhorne, Peter

    2014-12-01

    There are many randomized controlled trials relating to stroke rehabilitation being carried out in China, which are often published in Chinese-language journals. A recent update to our Cochrane systematic review of physical rehabilitation to improve function and mobility after stroke included 96 trials; over half (51) were conducted in China; 37 of these included studies were published in Chinese. Analyses within this Cochrane review support the conclusion that physical rehabilitation, using a mix of components from different approaches, is effective for the recovery of function and mobility after stroke. The inclusion of the Chinese studies had a substantial impact on the volume of evidence and, consequently, the conclusions. In this paper, we explore whether it is appropriate to draw implications for clinical practice throughout the world from evidence relating to a complex rehabilitation intervention delivered within one particular geographical healthcare setting. We explore the unique challenges associated with incorporating the body of evidence from China, particularly the Chinese-language publications, and identify the ongoing debate about the quality of Chinese research publications. We conclude that the growing body of evidence from China has important implications for future systematic reviews and evidence-based stroke care, but analysis and interpretation raise challenges, and improved reporting is critical. PMID:25381686

  2. Combinatorial Topology-based Semantic Clustering Applied to PubMed

    Microsoft Academic Search

    Wen-Wen Yang; I-Jen Chiang; Ruey-Ling Yeh; Hsiang-Chun Tsai

    2007-01-01

    To confront with an ever increasing number of published scientific articles, an effective, efficient, and easy-to-use tool is required to support biomedical scientists, while entering a new scientific field and encountering clinical decision, to organize a vast amount of PubMed abstracts into the panorama of specific topics according to their relevance. In brief, the set of associations among frequently co-occurring

  3. Towards Automatic Extraction of Social Networks of Organizations in PubMed Abstracts

    Microsoft Academic Search

    Siddhartha Jonnalagadda; Philip Topham; Graciela Gonzalez

    2010-01-01

    Social Network Analysis (SNA) of organizations can attract great interest\\u000afrom government agencies and scientists for its ability to boost translational\\u000aresearch and accelerate the process of converting research to care. For SNA of\\u000aa particular disease area, we need to identify the key research groups in that\\u000aarea by mining the affiliation information from PubMed. This not only involves

  4. Enabling multi-level relevance feedback on PubMed by integrating rank learning into DBMS

    PubMed Central

    2010-01-01

    Background Finding relevant articles from PubMed is challenging because it is hard to express the user's specific intention in the given query interface, and a keyword query typically retrieves a large number of results. Researchers have applied machine learning techniques to find relevant articles by ranking the articles according to the learned relevance function. However, the process of learning and ranking is usually done offline without integrated with the keyword queries, and the users have to provide a large amount of training documents to get a reasonable learning accuracy. This paper proposes a novel multi-level relevance feedback system for PubMed, called RefMed, which supports both ad-hoc keyword queries and a multi-level relevance feedback in real time on PubMed. Results RefMed supports a multi-level relevance feedback by using the RankSVM as the learning method, and thus it achieves higher accuracy with less feedback. RefMed "tightly" integrates the RankSVM into RDBMS to support both keyword queries and the multi-level relevance feedback in real time; the tight coupling of the RankSVM and DBMS substantially improves the processing time. An efficient parameter selection method for the RankSVM is also proposed, which tunes the RankSVM parameter without performing validation. Thereby, RefMed achieves a high learning accuracy in real time without performing a validation process. RefMed is accessible at http://dm.postech.ac.kr/refmed. Conclusions RefMed is the first multi-level relevance feedback system for PubMed, which achieves a high accuracy with less feedback. It effectively learns an accurate relevance function from the user’s feedback and efficiently processes the function to return relevant articles in real time. PMID:20406504

  5. Tracking the Growth of Drug Therapy Literature Using PubMed

    Microsoft Academic Search

    Dennis F. Thompson; Nancy Toedter Williams

    2007-01-01

    The biomedical literature has exploded over the past 50 years. The purpose of this study was to track the growth of drug therapy literature using the online provider PubMed. We utilized the first 20 Disease [C] MeSH listed on the 2005 MeSH tree structures for our study. Drug therapy literature was searched using the disease MeSH with the ending\\/drug therapy

  6. An analysis of gene/protein associations at PubMed scale

    PubMed Central

    2011-01-01

    Background Event extraction following the GENIA Event corpus and BioNLP shared task models has been a considerable focus of recent work in biomedical information extraction. This work includes efforts applying event extraction methods to the entire PubMed literature database, far beyond the narrow subdomains of biomedicine for which annotated resources for extraction method development are available. Results In the present study, our aim is to estimate the coverage of all statements of gene/protein associations in PubMed that existing resources for event extraction can provide. We base our analysis on a recently released corpus automatically annotated for gene/protein entities and syntactic analyses covering the entire PubMed, and use named entity co-occurrence, shortest dependency paths and an unlexicalized classifier to identify likely statements of gene/protein associations. A set of high-frequency/high-likelihood association statements are then manually analyzed with reference to the GENIA ontology. Conclusions We present a first estimate of the overall coverage of gene/protein associations provided by existing resources for event extraction. Our results suggest that for event-type associations this coverage may be over 90%. We also identify several biologically significant associations of genes and proteins that are not addressed by these resources, suggesting directions for further extension of extraction coverage. PMID:22166173

  7. PubMed and beyond: a survey of web tools for searching biomedical literature

    PubMed Central

    Lu, Zhiyong

    2011-01-01

    The past decade has witnessed the modern advances of high-throughput technology and rapid growth of research capacity in producing large-scale biological data, both of which were concomitant with an exponential growth of biomedical literature. This wealth of scholarly knowledge is of significant importance for researchers in making scientific discoveries and healthcare professionals in managing health-related matters. However, the acquisition of such information is becoming increasingly difficult due to its large volume and rapid growth. In response, the National Center for Biotechnology Information (NCBI) is continuously making changes to its PubMed Web service for improvement. Meanwhile, different entities have devoted themselves to developing Web tools for helping users quickly and efficiently search and retrieve relevant publications. These practices, together with maturity in the field of text mining, have led to an increase in the number and quality of various Web tools that provide comparable literature search service to PubMed. In this study, we review 28 such tools, highlight their respective innovations, compare them to the PubMed system and one another, and discuss directions for future development. Furthermore, we have built a website dedicated to tracking existing systems and future advances in the field of biomedical literature search. Taken together, our work serves information seekers in choosing tools for their needs and service providers and developers in keeping current in the field. Database URL: http://www.ncbi.nlm.nih.gov/CBBresearch/Lu/search PMID:21245076

  8. Text similarity: an alternative way to search MEDLINE

    Microsoft Academic Search

    James Lewis; Stephan Ossowski; Justin M. Hicks; Mounir Errami; Harold R. Garner

    2006-01-01

    Motivation: The most widely used literature search techniques, such as those offered by NCBI's PubMed system, require significant effort on the part of the searcher, and inexperienced searchers do not use these systems as effectively as experienced users. Im- proved literature search engines can save researchers time and effort by making it easier to locate the most important and relevant

  9. Comparing Medline citations using modified N-grams

    PubMed Central

    Nawab, Rao Muhammad Adeel; Stevenson, Mark; Clough, Paul

    2014-01-01

    Objective We aim to identify duplicate pairs of Medline citations, particularly when the documents are not identical but contain similar information. Materials and methods Duplicate pairs of citations are identified by comparing word n-grams in pairs of documents. N-grams are modified using two approaches which take account of the fact that the document may have been altered. These are: (1) deletion, an item in the n-gram is removed; and (2) substitution, an item in the n-gram is substituted with a similar term obtained from the Unified Medical Language System  Metathesaurus. N-grams are also weighted using a score derived from a language model. Evaluation is carried out using a set of 520 Medline citation pairs, including a set of 260 manually verified duplicate pairs obtained from the Deja Vu database. Results The approach accurately detects duplicate Medline document pairs with an F1 measure score of 0.99. Allowing for word deletions and substitution improves performance. The best results are obtained by combining scores for n-grams of length 1–5 words. Discussion Results show that the detection of duplicate Medline citations can be improved by modifying n-grams and that high performance can also be obtained using only unigrams (F1=0.959), particularly when allowing for substitutions of alternative phrases. PMID:23715801

  10. Weed Management in Alfalfa Stands Dr. Case R. Medlin

    E-print Network

    Weed Management in Alfalfa Stands Dr. Case R. Medlin Assistant Professor of Weed Science Purdue Weed ManagementWeed ManagementWeed ManagementWeed ManagementWeed Management Purdue Extension WS-11-W Weed infestations can reduce the yield, quality, and longevity of alfalfa stands. Low soil p

  11. Work of the Cochrane Bone, Joint and Muscle Trauma Review Group: making sense of complexity.

    PubMed

    Handoll, Helen

    2013-11-01

    This article examines the ways in which members of the Cochrane Bone, Joint and Muscle Trauma Review Group have tackled the intrinsic complexity of a large clinical area. This features a diversity of injuries in people of all ages, predominantly physical and surgical interventions that are inherently complex interventions, and a huge array of outcome measures. The methods described include a purposeful focus on common injuries, such as fragility fractures in older people; and the generation of groups of "all intervention" reviews whose structure is informed by a systematic approach, incorporating knowledge of clinical pathways and categorization of interventions. The article concludes with some thoughts about the challenges ahead, particularly in terms of selecting the scopes of future reviews. PMID:24325411

  12. Porosity distribution in San Andres Formation (Permian), Cochran and Hockley Counties, Texas

    SciTech Connect

    Cowan, P.E.; Harris, P.M.

    1986-06-01

    The lower San Andres Formation in Cochran and Hockley Counties, Texas, is one of the most prolific hydrocarbon-bearing horizons of the Permian basin. It is a cyclic sequence of shallow-water carbonates and evaporites which prograded across the northwest shelf toward the Midland and Delaware basins. San Andres production results from the vertical stacking of porous dolomite reservoirs. Stratigraphic trapping of hydrocarbons results from porosity pinch-outs defined by the degree of dolomitization and anhydrite plugging, both vertically near the top of depositional cycles, and on a regional scale. Stratigraphic trapping, combined with subtle structural nosing and changes in dip, define the limits of production. Reservoir zones are regionally correlatable and mappable. Major productive trends pinch out northward onto the Matador arch, defining this feature as a major influence on San Andres deposition and production.

  13. Celebrating methodological challenges and changes: reflecting on the emergence and importance of the role of qualitative evidence in Cochrane reviews

    PubMed Central

    2013-01-01

    Cochrane systematic reviews have proven to be beneficial for decision making processes, both on a practitioner and a policy level, and there are current initiatives to extend the types of evidence used by them, including qualitative research. In this article we outline the major achievements of the Cochrane Qualitative and Implementation Methods Group. Although the Group has encountered numerous challenges in dealing with the evolution of qualitative evidence synthesis, both outside and within the Cochrane Collaboration, it has successfully responded to the challenges posed in terms of incorporating qualitative evidence in systematic reviews. The Methods Group will continue to advocate for more flexible and inclusive approaches to evidence synthesis in order to meet the exciting challenges and opportunities presented by mixed methods systematic reviews and reviews of complex interventions. PMID:24135194

  14. The trend of indexed papers in PubMed covering different aspects of self-immolation.

    PubMed

    Rezaeian, Mohsen

    2014-01-01

    Self-immolation is a fatal and devastating method of committing suicide used around the world. The chief aim of the present article is to look at the trend of indexed papers in PubMed covering different aspects of self-immolation. PubMed search engine (http://www.ncbi.nlm.nih.gov) was searched by using six keywords i.e. "self-immolation", "self-inflicted burn", "self-burning", "self-incineration", "suicidal burns" and "suicide by burning". These keywords should appear either in the title or the abstract of the articles. The time frame was set as to retrieve papers expanding from early indexing time up to end of the year 2011. Based on the search strategy 132 papers were retrieved from these total numbers; 12 (9%) were categorized as review papers; 24 (18%) as case reports and the rest 96 (73%) were original studies. It seems that the number of papers increased during the years of investigations and the highest indexed papers i.e. 14 (10.6%) belonged to the year 2011. While most journals, published only one article the highest indexed papers i.e. 35 (26.5%) belonged to Burns. There was an increasing trend in the number of self-immolation articles indexed in PubMed since 1965. Three journals i.e. Burns, Journal of Burn Care and Rehabilitation and Journal of Forensic Sciences hosted for more than 37% of all those indexed articles. However, given the increasing trend of self-immolation still more studies are needed to shed light on the diverse aspects of this appalling human behavior. PMID:24659075

  15. Twelve Years of Scientific Production on Medline by Latin American Spine Surgeons

    PubMed Central

    Falavigna, Asdrubal; Botelho, Ricardo Vieira; Teles, Alisson Roberto; Guarise da Silva, Pedro; Martins, Delio; Guyot, Juan Pablo; Gonzalez, Alvaro Silva; Avila, José Maria Jiménez; Defino, Helton Luiz Aparecido

    2014-01-01

    Background Despite the small contribution of LA in the Science Citation Index (SCI), a growing contribution by LA research to international literature has been observed in recent years. Study Design Systematic review. Purpose To evaluate the scientific contribution of Latin American (LA) Spine Surgeons in the last decade. Methods A literature search of publications by LA spinal surgeons on topics concerning the spine or spinal cord was performed using an online database; Pubmed.gov. The results were limited to articles published from January 2000 to December 2011. The quality of the publication was evaluated with the journal impact factor (IF), Oxford classification and number of citations. Results This study comprised 320 articles published in the Medline database by LA spine surgeons from 2000 to 2011. In recent years, there has been an increase in the number of publications by LA spine surgeons. It was observed that 38.4% of LA papers were published in LA journals. 46.6% of the articles were published in journals with an IF lower than 1, and there was no statistically significant difference in the number of articles published in journals with a higher IF during the period. Linear-by-linear association analysis demonstrated an improvement in the level of evidence provided by LA articles published in recent years. Conclusions This study showed a growth in the number of publications in last 12 years by LA spinal surgeons. It is necessary to discuss a way to increase quantity and quality of scientific publications, mainly through a better education in research. PMID:24505336

  16. MedlinePlus Connect: Linking Patient Portals and Electronic Health Records to Health Information

    MedlinePLUS

    Skip navigation U.S. National Library of Medicine Menu Health Topics Drugs & Supplements Videos & Tools About MedlinePlus Search ... GO About MedlinePlus Site Map FAQs Contact Us Health Topics Drugs & Supplements Videos & Tools You Are Here: ...

  17. Finding Answers in a Beauty Shop | NIH MedlinePlus the Magazine

    MedlinePLUS

    ... customers the MedlinePlus website. Dexter Waiters uses the computer at MaFlo's to access the MedlinePlus consumer health ... A waiting area offers several comfortable chairs, three computers, and a printer. On a typical day, the ...

  18. A MedlinePlus® Kiosk Promoting Health Literacy

    PubMed Central

    TEOLIS, MARILYN G.

    2010-01-01

    As an ongoing community outreach project, a pictorial touch-screen kiosk and Web site was developed for 48 MedlinePlus® tutorials. This learning experience serves Davidson County, Tennessee’s uninsured patients at the University of Tennessee/Baptist Hospital’s Internal Medicine Clinic. The availability of a health information kiosk at the University of Tennessee/Baptist Hospital primary care clinic significantly increases health literacy for patients by providing reliable, physician-recommended information in an appropriate format—information these patients did not previously find readily available. Participants report they have a greater understanding of their health issues, and the project is introducing hundreds of patients to MedlinePlus. PMID:20808715

  19. PubMed vs. HighWire Press: A head-to-head comparison of two medical literature search engines

    Microsoft Academic Search

    Thomas E. Vanhecke; Michael A. Barnes; Janet Zimmerman; Sandor Shoichet

    2007-01-01

    PubMed and HighWire Press are both useful medical literature search engines available for free to anyone on the internet. We measured retrieval accuracy, number of results generated, retrieval speed, features and search tools on HighWire Press and PubMed using the quick search features of each. We found that using HighWire Press resulted in a higher likelihood of retrieving the desired

  20. MedlinePlus Goes Local in NC: Context and Concept

    Microsoft Academic Search

    Carol G. Jenkins; Joanne Gard Marshall; Diana McDuffee

    2004-01-01

    NC Health Info is a col- lection of online North Carolina-based health services Web sites that link seamlessly with health information on MedlinePlus, the National Li- brary of Medicine's Web site. NC Health Info is the result of a pilot study to define the components involved in creating such a system and serves as a model to be used

  1. Identifying well-formed biomedical phrases in MEDLINE® text

    PubMed Central

    Kim, Won; Yeganova, Lana; Comeau, Donald C.; Wilbur, W. John

    2012-01-01

    In the modern world people frequently interact with retrieval systems to satisfy their information needs. Humanly understandable well-formed phrases represent a crucial interface between humans and the web, and the ability to index and search with such phrases is beneficial for human-web interactions. In this paper we consider the problem of identifying humanly understandable, well formed, and high quality biomedical phrases in MEDLINE documents. The main approaches used previously for detecting such phrases are syntactic, statistical, and a hybrid approach combining these two. In this paper we propose a supervised learning approach for identifying high quality phrases. First we obtain a set of known well-formed useful phrases from an existing source and label these phrases as positive. We then extract from MEDLINE a large set of multiword strings that do not contain stop words or punctuation. We believe this unlabeled set contains many well-formed phrases. Our goal is to identify these additional high quality phrases. We examine various feature combinations and several machine learning strategies designed to solve this problem. A proper choice of machine learning methods and features identifies in the large collection strings that are likely to be high quality phrases. We evaluate our approach by making human judgments on multiword strings extracted from MEDLINE using our methods. We find that over 85% of such extracted phrase candidates are humanly judged to be of high quality. PMID:22683889

  2. The reporting characteristics and methodological quality of Cochrane reviews about health policy research.

    PubMed

    Xiu-xia, Li; Ya, Zheng; Yao-long, Chen; Ke-hu, Yang; Zong-jiu, Zhang

    2015-04-01

    The systematic review has increasingly become a popular tool for researching health policy. However, due to the complexity and diversity in the health policy research, it has also encountered more challenges. We set out the Cochrane reviews on health policy research as a representative to provide the first examination of epidemiological and descriptive characteristics as well as the compliance of methodological quality with the AMSTAR. 99 reviews were included by inclusion criteria, 73% of which were Implementation Strategies, 15% were Financial Arrangements and 12% were Governance Arrangements; involved Public Health (34%), Theoretical Exploration (18%), Hospital Management (17%), Medical Insurance (12%), Pharmaceutical Policy (9%), Community Health (7%) and Rural Health (2%). Only 39% conducted meta-analysis, and 49% reported being updates, and none was rated low methodological quality. Our research reveals that the quantity and quality of the evidence should be improved, especially Financial Arrangements and Governance Arrangements involved Rural Health, Health Care Reform and Health Equity, etc. And the reliability of AMSTAR needs to be tested in larger range in this field. PMID:25260911

  3. The Cochrane Fertility Regulation Group: synthesizing the best evidence about family planning.

    PubMed

    Helmerhorst, Frans M; Belfield, Toni; Kulier, Regina; Maitra, Nandita; O'Brien, Paul; Grimes, David A

    2006-10-01

    The Fertility Regulation Group of the Cochrane Collaboration has been assessing the best available evidence on fertility regulation, family size and birth spacing. By the end of 2005, this group had published 32 systematic reviews and 12 protocols; most reviews were on contraception. Because of suboptimal trial quality, firm conclusions could be made in only five reviews. Threats to internal validity in published trials include the absence of description of allocation concealment, intentional exclusion of participants after randomization, failure to use intention-to-treat analyses and lack of treatment blinding. The precision of results has been limited by small sample sizes. The finding that most trials of oral contraceptives were conducted by pharmaceutical companies raises concerns about potential commercial bias. Of necessity, most information about fertility regulation effectiveness and adverse effects comes from observational studies, which vary widely in quality. Systematic reviews of evidence, with an emphasis on randomized controlled trials when available, will continue to improve fertility regulation in the years ahead. PMID:16982225

  4. PubCrawler: keeping up comfortably with PubMed and GenBank.

    PubMed

    Hokamp, Karsten; Wolfe, Kenneth H

    2004-07-01

    The free PubCrawler web service (http://www.pubcrawler.ie) has been operating for five years and so far has brought literature and sequence updates to over 22 000 users. It provides information on a personalized web page whenever new articles appear in PubMed or when new sequences are found in GenBank that are specific to customized queries. The server also acts as an automatic alerting system by sending out short notifications or emails with the latest updates as soon as they become available. A new output format and more flexibility for the email formatting help PubCrawler cope with increasing challenges arising from browser incompatibilities and mail filters, therefore making it suitable for a wide range of users. PMID:15215341

  5. Mental health publications from the Arab world cited in PubMed, 1987-2002.

    PubMed

    Afifi, M M

    2005-05-01

    The study aimed to identify mental health publications in Arab countries cited in PubMed from 1987 to 2002 and to analyse the year of publication, journal and field of research, specifically for child and adolescent mental health studies. A PubMedsearch was performed for all mental health publications followed by an analysis of child and adolescent mental health citations. The total number of mental health research citations published in Arab countries over the last 15 years was 338, 1.2% of the total number of citations for biomedical research; 17% were on child and adolescent mental health. The most dynamic fields of mental health research are anxiety and mood disorders and substance abuse. Child psychiatry, especially attention deficit hyperactivity disorder and child autism, are not gaining much interest from Arab researchers. PMID:16602450

  6. Factor Analytic Approach to Transitive Text Mining using Medline Descriptors

    NASA Astrophysics Data System (ADS)

    Stegmann, J.; Grohmann, G.

    Matrix decomposition methods were applied to examples of noninteractive literature sets sharing implicit relations. Document-by-term matrices were created from downloaded PubMed literature sets, the terms being the Medical Subject Headings (MeSH descriptors) assigned to the documents. The loadings of the factors derived from singular value or eigenvalue matrix decomposition were sorted according to absolute values and subsequently inspected for positions of terms relevant to the discovery of hidden connections. It was found that only a small number of factors had to be screened to find key terms in close neighbourhood, being separated by a small number of terms only.

  7. Non-steroidal antiandrogen monotherapy compared with luteinizing hormone-releasing hormone agonists or surgical castration monotherapy for advanced prostate cancer: a Cochrane systematic review.

    PubMed

    Kunath, Frank; Grobe, Henrik R; Rücker, Gerta; Motschall, Edith; Antes, Gerd; Dahm, Philipp; Wullich, Bernd; Meerpohl, Joerg J

    2015-07-01

    To assess the effects of non-steroidal antiandrogen monotherapy compared with luteinizing hormone-releasing hormone agonists or surgical castration monotherapy for treating advanced hormone-sensitive stages of prostate cancer. We searched the Cochrane Prostatic Diseases and Urologic Cancers Group Specialized Register (PROSTATE), the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, Web of Science with Conference Proceedings, three trial registries and abstracts from three major conferences to 23 December 2013, together with reference lists, and contacted selected experts in the field and manufacturers. We included randomized controlled trials comparing non-steroidal antiandrogen monotherapy with medical or surgical castration monotherapy for men in advanced hormone-sensitive stages of prostate cancer. Two review authors independently examined full-text reports, identified relevant studies, assessed the eligibility of studies for inclusion, extracted data and assessed risk of bias as well as quality of evidence according to the GRADE working group guidelines. We used Review Manager 5.2 for data synthesis and the fixed-effect model as primary analysis (when heterogeneity was low with I(2)  < 50%); we used a random-effects model when confronted with substantial or considerable heterogeneity (when I(2) ?50%). A total of 11 studies involving 3060 randomly assigned participants were included in the present review. Use of non-steroidal antiandrogens resulted in lower overall survival times (hazard ratio [HR] 1.24, 95% confidence interval [CI] 1.05-1.48, six studies, 2712 participants) and greater clinical progression (1 year: risk ratio [RR] 1.25, 95% CI 1.08-1.45, five studies, 2067 participants; 70 weeks: RR 1.26, 95% CI 1.08-1.45, six studies, 2373 participants; 2 years: RR 1.14, 95% CI 1.04-1.25, three studies, 1336 participants), as well as treatment failure (1 year: RR 1.19, 95% CI 1.02-1.38, four studies, 1539 participants; 70 weeks: RR 1.27, 95% CI 1.05-1.52, five studies, 1845 participants; 2 years: RR 1.14, 95% CI 1.05-1.24, two studies, 808 participants), compared with medical or surgical castration. The quality of evidence for overall survival, clinical progression and treatment failure was rated as moderate according to GRADE. Use of non-steroidal antiandrogens increased the risk for treatment discontinuation as a result of adverse events (RR 1.82, 95% CI 1.13-2.94, eight studies, 1559 participants), including events such as breast pain (RR 22.97, 95% CI 14.79- 35.67, eight studies, 2670 participants) and gynaecomastia (RR 8.43, 95% CI 3.19-22.28, nine studies, 2774 participants) The risk of other adverse events, such as hot flushes (RR 0.23, 95% CI 0.19-0.27, nine studies, 2774 participants) was decreased when non-steroidal antiandrogens were used. The quality of evidence for breast pain, gynaecomastia and hot flushes was rated as moderate according to GRADE. The effects of non-steroidal antiandrogens on cancer-specific survival and biochemical progression remained unclear. Non-steroidal antiandrogen monotherapy compared with medical or surgical castration monotherapy for advanced prostate cancer is less effective in terms of overall survival, clinical progression, treatment failure and treatment discontinuation resulting from adverse events. Evidence quality was rated as moderate according to GRADE; therefore, further research is likely to have an important impact on results for patients with advanced but non-metastatic prostate cancer treated with non-steroidal antiandrogen monotherapy. PMID:25523493

  8. Enhancing search efficiency by means of a search filter for finding all studies on animal experimentation in PubMed

    PubMed Central

    Hooijmans, Carlijn R; Tillema, Alice; Leenaars, Marlies; Ritskes-Hoitinga, Merel

    2010-01-01

    Collecting and analysing all available literature before starting an animal experiment is important and it is indispensable when writing a systematic review (SR) of animal research. Writing such review prevents unnecessary duplication of animal studies and thus unnecessary animal use (Reduction). One of the factors currently impeding the production of ‘high-quality’ SRs in laboratory animal science is the fact that searching for all available literature concerning animal experimentation is rather difficult. In order to diminish these difficulties, we developed a search filter for PubMed to detect all publications concerning animal studies. This filter was compared with the method most frequently used, the PubMed Limit: Animals, and validated further by performing two PubMed topic searches. Our filter performs much better than the PubMed limit: it retrieves, on average, 7% more records. Other important advantages of our filter are that it also finds the most recent records and that it is easy to use. All in all, by using our search filter in PubMed, all available literature concerning animal studies on a specific topic can easily be found and assessed, which will help in increasing the scientific quality and thereby the ethical validity of animal experiments. PMID:20551243

  9. Using Topic Models to Interpret MEDLINE's Medical Subject Headings

    NASA Astrophysics Data System (ADS)

    Newman, David; Karimi, Sarvnaz; Cavedon, Lawrence

    We consider the task of interpreting and understanding a taxonomy of classification terms applied to documents in a collection. In particular, we show how unsupervised topic models are useful for interpreting and understanding MeSH, the Medical Subject Headings applied to articles in MEDLINE. We introduce the resampled author model, which captures some of the advantages of both the topic model and the author-topic model. We demonstrate how topic models complement and add to the information conveyed in a traditional listing and description of a subject heading hierarchy.

  10. [Keeping up to date with the relevant literature: 'really simple syndication'-(RSS)-feeds within PubMed].

    PubMed

    Leclercq, E; Kremer, L C M

    2008-01-26

    For clinicians, researchers and policy makers in healthcare, it is important to keep up to date with the newest medical-scientific information. The large amount of new information makes this a difficult task. There are various techniques for keeping up to date, for instance reading systematic reviews, searching the literature at regular intervals oneself, and using the e-mail alerting services of, for example, PubMed. A new possibility is to be alerted to new scientific publications, for example, via a 'really simple syndication' (RSS)-feed. This option is now also made available by PubMed. In addition to PubMed, many other websites can now be searched systematically for new information by a RSS reader. With RSS feeds the user can be alerted to new information much faster than by an e-mail alerting service, so that one can anticipate new developments more rapidly. PMID:18320950

  11. Commentary on Cochrane review of neuraminidase inhibitors for preventing and treating influenza in healthy adults and children.

    PubMed

    Jones, M; Jefferson, T; Doshi, P; Del Mar, C; Heneghan, C; Onakpoya, I

    2015-03-01

    In recent years there has been much debate and controversy surrounding the efficacy and safety of neuraminidase inhibitors for influenza, in part because the data underlying certain efficacy claims were not available for independent scrutiny. In 2014, a Cochrane review was published, based exclusively on an almost complete set of clinical study reports and other regulatory documents. Clinical study reports can run to thousands of pages, providing an extensive amount of information on the planning, conduct and results of each trial. After a protracted campaign to obtain the reports, the manufacturers of the medications provided them unconditionally. The review authors subsequently published the underlying documents simultaneously with the Cochrane review, endorsing the concept of open science. In the following commentary, the background to and results of this review are summarized and put into clinical context. PMID:25658541

  12. Stochastic Gradient Descent and the Prediction of MeSH for PubMed Records

    PubMed Central

    Wilbur, W. John; Kim, Won

    2014-01-01

    Stochastic Gradient Descent (SGD) has gained popularity for solving large scale supervised machine learning problems. It provides a rapid method for minimizing a number of loss functions and is applicable to Support Vector Machine (SVM) and Logistic optimizations. However SGD does not provide a convenient stopping criterion. Generally an optimal number of iterations over the data may be determined using held out data. Here we compare stopping predictions based on held out data with simply stopping at a fixed number of iterations and show that the latter works as well as the former for a number of commonly studied text classification problems. In particular fixed stopping works well for MeSH® predictions on PubMed® records. We also surveyed the published algorithms for SVM learning on large data sets, and chose three for comparison: PROBE, SVMperf, and Liblinear and compared them with SGD with a fixed number of iterations. We find SGD with a fixed number of iterations performs as well as these alternative methods and is much faster to compute. As an application we made SGD-SVM predictions for all MeSH terms and used the Pool Adjacent Violators (PAV) algorithm to convert these predictions to probabilities. Such probabilistic predictions lead to ranked MeSH term predictions superior to previously published results on two test sets. PMID:25954431

  13. PIE the search: searching PubMed literature for protein interaction information

    PubMed Central

    Kim, Sun; Kwon, Dongseop; Shin, Soo-Yong; Wilbur, W. John

    2012-01-01

    Motivation: Finding protein-protein interaction (PPI) information from literature is challenging but an important issue. However, keyword search in PubMed® is often time consuming because it requires a series of actions that refine keywords and browse search results until it reaches a goal. Due to the rapid growth of biomedical literature, it has become more difficult for biologists and curators to locate PPI information quickly. Therefore, a tool for prioritizing PPI informative articles can be a useful assistant for finding this PPI-relevant information. Results: PIE (Protein Interaction information Extraction) the search is a web service implementing a competition-winning approach utilizing word and syntactic analyses by machine learning techniques. For easy user access, PIE the search provides a PubMed-like search environment, but the output is the list of articles prioritized by PPI confidence scores. By obtaining PPI-related articles at high rank, researchers can more easily find the up-to-date PPI information, which cannot be found in manually curated PPI databases. Availability: http://www.ncbi.nlm.nih.gov/IRET/PIE/ Contact: sun.kim@nih.gov Supplementary information: Supplementary data are available at Bioinformatics online. PMID:22199390

  14. Searching PubMed for molecular epidemiology studies: the case of chromosome aberrations.

    PubMed

    Ugolini, Donatella; Neri, Monica; Knudsen, Lisbeth E; Bonassi, Stefano; Merlo, Domenico Franco

    2006-05-01

    The available tools for searching literature in the field of Molecular Epidemiology are largely unsatisfactory. To identify major problems in retrieving information on this discipline, we comment here on the results of a literature search on cytogenetic biomarkers in children exposed to environmental pollutants. The search, done on the PubMed/MedLine database, was based on a strategy combining descriptors listed in the PubMed Medical Subject Headings (MeSH) Thesaurus and other available tools (free text or phrase search tools). 178 articles were retrieved by searching the period from January 1, 1980 to November 30, 2004. Only 2 of the 178 articles were indexed by the MeSH term "Epidemiology, molecular" (introduced in 1994) and 30 of 178 by the MeSH term "Biological markers" (introduced in 1989). The case of chromosome aberration (CA) was emblematic of the problem: 44 of 78 articles (56.4%) were not pertinent to the search. The reasons for this poor performance are reported and discussed. Authors and indexers may be able to improve the efficiency of article retrieval in the field of molecular epidemiology by using relevant terms in the title and abstract. This may suggest appropriate MeSH terms to the indexers for the indexing process. As regards the difficulty in identifying population studies using CA, the introduction of a specific MeSH term for chromosome aberrations when used as a biomarker would improve the search process. PMID:16416429

  15. Linking Tacit Knowledge in the Pediatric Pain e-Mail Archives and Explicit Knowledge in PubMed

    E-print Network

    Abidi, Syed Sibte Raza

    Linking Tacit Knowledge in the Pediatric Pain e-Mail Archives and Explicit Knowledge in Pub and linked directly to the explicit knowledge found in PubMed. The Pediatric Pain Mailing List (PPML of pediatric pain has been recognized widely in the past fifteen years. Although knowledge about pediatric pain

  16. Combining PubMed Knowledge and EHR Data to Develop a Weighted Bayesian Network for Pancreatic Cancer Prediction

    PubMed Central

    Zhao, Di; Weng, Chunhua

    2011-01-01

    In this paper, we propose a novel method that combines PubMed knowledge and Electronic Health Records to develop a weighted Bayesian Network Inference (BNI) model for pancreatic cancer prediction. We selected 20 common risk factors associated with pancreatic cancer and used PubMed knowledge to weigh the risk factors. A keyword-based algorithm was developed to extract and classify PubMed abstracts into three categories that represented positive, negative, or neutral associations between each risk factor and pancreatic cancer. Then we designed a weighted BNI model by adding the normalized weights into a conventional BNI model. We used this model to extract the EHR values for patients with or without pancreatic cancer, which then enabled us to calculate the prior probabilities for the 20 risk factors in the BNI. The software iDiagnosis was designed to use this weighted BNI model for predicting pancreatic cancer. In an evaluation using a case-control dataset, the weighted BNI model significantly outperformed the conventional BNI and two other classifiers (k-Nearest Neighbor and Support Vector Machine). We conclude that the weighted BNI using PubMed knowledge and EHR data shows remarkable accuracy improvement over existing representative methods for pancreatic cancer prediction. PMID:21642013

  17. Shifting Sands: Science Researchers on Google Scholar, Web of Science, and PubMed, with Implications for Library Collections Budgets

    ERIC Educational Resources Information Center

    Hightower, Christy; Caldwell, Christy

    2010-01-01

    Science researchers at the University of California Santa Cruz were surveyed about their article database use and preferences in order to inform collection budget choices. Web of Science was the single most used database, selected by 41.6%. Statistically there was no difference between PubMed (21.5%) and Google Scholar (18.7%) as the second most…

  18. Public accessibility of biomedical articles from PubMed Central reduces journal readership--retrospective cohort analysis.

    PubMed

    Davis, Philip M

    2013-07-01

    Does PubMed Central--a government-run digital archive of biomedical articles--compete with scientific society journals? A longitudinal, retrospective cohort analysis of 13,223 articles (5999 treatment, 7224 control) published in 14 society-run biomedical research journals in nutrition, experimental biology, physiology, and radiology between February 2008 and January 2011 reveals a 21.4% reduction in full-text hypertext markup language (HTML) article downloads and a 13.8% reduction in portable document format (PDF) article downloads from the journals' websites when U.S. National Institutes of Health-sponsored articles (treatment) become freely available from the PubMed Central repository. In addition, the effect of PubMed Central on reducing PDF article downloads is increasing over time, growing at a rate of 1.6% per year. There was no longitudinal effect for full-text HTML downloads. While PubMed Central may be providing complementary access to readers traditionally underserved by scientific journals, the loss of article readership from the journal website may weaken the ability of the journal to build communities of interest around research papers, impede the communication of news and events to scientific society members and journal readers, and reduce the perceived value of the journal to institutional subscribers. PMID:23554455

  19. Semi-automatic semantic annotation of PubMed Queries: a study on quality, efficiency, satisfaction

    PubMed Central

    Névéol, Aurélie; Islamaj-Do?an, Rezarta; Lu, Zhiyong

    2010-01-01

    Information processing algorithms require significant amounts of annotated data for training and testing. The availability of such data is often hindered by the complexity and high cost of production. In this paper, we investigate the benefits of a state-of-the-art tool to help with the semantic annotation of a large set of biomedical information queries. Seven annotators were recruited to annotate a set of 10,000 PubMed® queries with 16 biomedical and bibliographic categories. About half of the queries were annotated from scratch, while the other half were automatically pre-annotated and manually corrected. The impact of the automatic pre-annotations was assessed on several aspects of the task: time, number of actions, annotator satisfaction, inter-annotator agreement, quality and number of the resulting annotations. The analysis of annotation results showed that the number of required hand annotations is 28.9% less when using pre-annotated results from automatic tools. As a result, the overall annotation time was substantially lower when pre-annotations were used, while inter-annotator agreement was significantly higher. In addition, there was no statistically significant difference in the semantic distribution or number of annotations produced when pre-annotations were used. The annotated query corpus is freely available to the research community. This study shows that automatic pre-annotations are found helpful by most annotators. Our experience suggests using an automatic tool to assist large-scale manual annotation projects. This helps speed-up the annotation time and improve annotation consistency while maintaining high quality of the final annotations. PMID:21094696

  20. Exploring Treatment by Covariate Interactions Using Subgroup Analysis and Meta-Regression in Cochrane Reviews: A Review of Recent Practice

    PubMed Central

    Donegan, Sarah; Williams, Lisa; Tudur-Smith, Catrin

    2015-01-01

    Background Treatment by covariate interactions can be explored in reviews using interaction analyses (e.g., subgroup analysis). Such analyses can provide information on how the covariate modifies the treatment effect and is an important methodological approach for personalising medicine. Guidance exists regarding how to apply such analyses but little is known about whether authors follow the guidance. Methods Using published recommendations, we developed criteria to assess how well interaction analyses were designed, applied, interpreted, and reported. The Cochrane Database of Systematic Reviews was searched (8th August 2013). We applied the criteria to the most recently published review, with an accessible protocol, for each Cochrane Review Group. We excluded review updates, diagnostic test accuracy reviews, withdrawn reviews, and overviews of reviews. Data were summarised regarding reviews, covariates, and analyses. Results Each of the 52 included reviews planned or did interaction analyses; 51 reviews (98%) planned analyses and 33 reviews (63%) applied analyses. The type of analysis planned and the type subsequently applied (e.g., sensitivity or subgroup analysis) was discrepant in 24 reviews (46%). No review reported how or why each covariate had been chosen; 22 reviews (42%) did state each covariate a priori in the protocol but no review identified each post-hoc covariate as such. Eleven reviews (21%) mentioned five covariates or less. One review reported planning to use a method to detect interactions (i.e., interaction test) for each covariate; another review reported applying the method for each covariate. Regarding interpretation, only one review reported whether an interaction was detected for each covariate and no review discussed the importance, or plausibility, of the results, or the possibility of confounding for each covariate. Conclusions Interaction analyses in Cochrane Reviews can be substantially improved. The proposed criteria can be used to help guide the reporting and conduct of analyses. PMID:26029923

  1. Evidence for non-communicable diseases: analysis of Cochrane reviews and randomised trials by World Bank classification

    PubMed Central

    Heneghan, C; Blacklock, C; Perera, R; Davis, R; Banerjee, A; Gill, P; Liew, S; Chamas, L; Hernandez, J; Mahtani, K; Hayward, G; Harrison, S; Lasserson, D; Mickan, S; Sellers, C; Carnes, D; Homer, K; Steed, L; Ross, J; Denny, N; Goyder, C; Thompson, M; Ward, A

    2013-01-01

    Introduction Prevalence of non-communicable diseases (NCDs) is increasing globally, with the greatest projected increases in low-income and middle-income countries. We sought to quantify the proportion of Cochrane evidence relating to NCDs derived from such countries. Methods We searched the Cochrane database of systematic reviews for reviews relating to NCDs highlighted in the WHO NCD action plan (cardiovascular, cancers, diabetes and chronic respiratory diseases). We excluded reviews at the protocol stage and those that were repeated or had been withdrawn. For each review, two independent researchers extracted data relating to the country of the corresponding author and the number of trials and participants from countries, using the World Bank classification of gross national income per capita. Results 797 reviews were analysed, with a reported total number of 12?340 trials and 10?937?306 participants. Of the corresponding authors 90% were from high-income countries (41% from the UK). Of the 746 reviews in which at least one trial had met the inclusion criteria, only 55% provided a summary of the country of included trials. Analysis of the 633 reviews in which country of trials could be established revealed that almost 90% of trials and over 80% of participants were from high-income countries. 438 (5%) trials including 1?145?013 (11.7%) participants were undertaken in low-middle income countries. We found that only 13 (0.15%) trials with 982 (0.01%) participants were undertaken in low-income countries. Other than the five Cochrane NCD corresponding authors from South Africa, only one other corresponding author was from Africa (Gambia). Discussion The overwhelming body of evidence for NCDs pertains to high-income countries, with only a small number of review authors based in low-income settings. As a consequence, there is an urgent need for research infrastructure and funding for the undertaking of high-quality trials in this area. PMID:23833146

  2. Physical Activity Measurement Instruments for Children with Cerebral Palsy: A Systematic Review

    ERIC Educational Resources Information Center

    Capio, Catherine M.; Sit, Cindy H. P.; Abernethy, Bruce; Rotor, Esmerita R.

    2010-01-01

    Aim: This paper is a systematic review of physical activity measurement instruments for field-based studies involving children with cerebral palsy (CP). Method: Database searches using PubMed Central, MEDLINE, CINAHL Plus, PsycINFO, EMBASE, Cochrane Library, and PEDro located 12 research papers, identifying seven instruments that met the inclusion…

  3. Monoamine oxidase type B inhibitors in early Parkinson's disease: meta-analysis of 17 randomised trials involving 3525 patients

    Microsoft Academic Search

    Natalie J Ives; Rebecca L Stowe; Joanna Marro; Carl Counsell; Angus Macleod; Richard Gray; Keith Wheatley

    2004-01-01

    Objective To quantify more reliably the benefits and risks of monoamine oxidase type B inhibitors (MAOBIs) in early Parkinson's disease. Data sources Searches of the Cochrane Library, Medline, Embase, PubMed, and Web of Science for years 1966-2003, plus major journals in the field, abstract books, and proceedings of meetings, for randomised trials comparing MAOBIs with placebo or levodopa. Data extraction

  4. Early Childhood Dental Caries: A Rising Dental Public Health Crisis

    ERIC Educational Resources Information Center

    Gomez, Grace Felix

    2013-01-01

    The aim of this article is to examine the literature and review the risk factors and disparities contributing to early childhood caries (ECC), which is a major health problem among preschoolers in the United States of America. A search was conducted using MEDLINE, PubMed, Google Scholar, and the Cochrane Library databases and the key terms…

  5. The Relationship between Sugar-Containing Methadone and Dental Caries: A Systematic Review

    ERIC Educational Resources Information Center

    Tripathee, Sheela; Akbar, Tahira; Richards, Derek; Themessl-Huber, Markus; Freeman, Ruth

    2013-01-01

    Objectives: To review the evidence of a relationship between sugar-containing methadone and dental caries. Data sources: A systematic search of Cochrane Library, PubMed, PsychINFO, EMBASE, MEDLINE, Current Controlled Trials, WHO, OHRN, SIGLE and ERIC databases was conducted from January 1978 up to June 2010. Study selection: Articles were assessed…

  6. GoPubMed: ontology-based literature search applied to Gene Ontology and PubMed

    Microsoft Academic Search

    Ralph Delfs; Andreas Doms; Alexander Kozlenkov; Michael Schroeder

    2004-01-01

    The biomedical literature grows at a tremendous rate, so that find- ing the relevant literature is becoming more and more difficult. To address this problem we introduce ontology-based literature search, which structures search results thorugh the categories of an ontology. We develop and implement GoP- ubMed, which submits keywords to PubMed, extracts GeneOntology-terms from the retrieved abstracts, and presents the

  7. STM publishing meets NIH digital archive: librarian service on the PubMed Central National Advisory Committee

    Microsoft Academic Search

    J. Michael Homan; Linda A. Watson

    2004-01-01

    The PubMed Central (PMC) National Advisory Committee was established by the National Institutes of Health in 1999 to guide the development of a new, open-access digital repository of biomedical research reports. Headquartered at the National Library of Medicine’s National Center for Biotechnology Information, PMC has achieved significant technical accomplishments, including a recommended publisher document type definition for digital archiving, but

  8. PCorral--interactive mining of protein interactions from MEDLINE.

    PubMed

    Li, Chen; Jimeno-Yepes, Antonio; Arregui, Miguel; Kirsch, Harald; Rebholz-Schuhmann, Dietrich

    2013-01-01

    The extraction of information from the scientific literature is a complex task-for researchers doing manual curation and for automatic text processing solutions. The identification of protein-protein interactions (PPIs) requires the extraction of protein named entities and their relations. Semi-automatic interactive support is one approach to combine both solutions for efficient working processes to generate reliable database content. In principle, the extraction of PPIs can be achieved with different methods that can be combined to deliver high precision and/or high recall results in different combinations at the same time. Interactive use can be achieved, if the analytical methods are fast enough to process the retrieved documents. PCorral provides interactive mining of PPIs from the scientific literature allowing curators to skim MEDLINE for PPIs at low overheads. The keyword query to PCorral steers the selection of documents, and the subsequent text analysis generates high recall and high precision results for the curator. The underlying components of PCorral process the documents on-the-fly and are available, as well, as web service from the Whatizit infrastructure. The human interface summarizes the identified PPI results, and the involved entities are linked to relevant resources and databases. Altogether, PCorral serves curator at both the beginning and the end of the curation workflow for information retrieval and information extraction. Database URL: http://www.ebi.ac.uk/Rebholz-srv/pcorral. PMID:23640984

  9. Intelligent system for topic survey in MEDLINE by keyword recommendation and learning text characteristics.

    PubMed

    Tanaka, M; Nakazono, S; Matsuno, H; Tsujimoto, H; Kitamura, Y; Miyano, S

    2000-01-01

    We have implemented a system for assisting experts in selecting MEDLINE records for database construction purposes. This system has two specific features: The first is a learning mechanism which extracts characteristics in the abstracts of MEDLINE records of interest as patterns. These patterns reflect selection decisions by experts and are used for screening the records. The second is a keyword recommendation system which assists and supplements experts' knowledge in unexpected cases. Combined with a conventional keyword-based information retrieval system, this system may provide an efficient and comfortable environment for MEDLINE record selection by experts. Some computational experiments are provided to prove that this idea is useful. PMID:11700589

  10. Finding Good Health Information on the Internet | NIH MedlinePlus the Magazine

    MedlinePLUS

    ... MedlinePlus Advantage Finding Good Health Information on the Internet Past Issues / Winter 2015 Table of Contents Millions ... get health information from magazines, TV, or the Internet. Some is reliable and up to date, some ...

  11. Building Paths to Health Careers | NIH MedlinePlus the Magazine

    MedlinePLUS

    ... in a health professional career. Courses were uniformly rated as highly effective and worthwhile. The program is ... site: www.fnlm.org Mobile MedlinePlus! Trusted medical information on your mobile phone. http://m.medlineplus.gov ...

  12. What Research is being done? | NIH MedlinePlus the Magazine

    MedlinePLUS

    ... this page please turn Javascript on. Feature: Stroke Rehabilitation What Research is Being Done? Past Issues / Spring ... of Contents To Find Out More MedlinePlus: Stroke Rehabilitation www.nlm.nih.gov/medlineplus/strokerehabilitation.html National ...

  13. Automated Patent Categorization and Guided Patent Search using IPC as Inspired by MeSH and PubMed.

    PubMed

    Eisinger, Daniel; Tsatsaronis, George; Bundschus, Markus; Wieneke, Ulrich; Schroeder, Michael

    2013-04-15

    Document search on PubMed, the pre-eminent database for biomedical literature, relies on the annotation of its documents with relevant terms from the Medical Subject Headings ontology (MeSH) for improving recall through query expansion. Patent documents are another important information source, though they are considerably less accessible. One option to expand patent search beyond pure keywords is the inclusion of classification information: Since every patent is assigned at least one class code, it should be possible for these assignments to be automatically used in a similar way as the MeSH annotations in PubMed. In order to develop a system for this task, it is necessary to have a good understanding of the properties of both classification systems. This report describes our comparative analysis of MeSH and the main patent classification system, the International Patent Classification (IPC). We investigate the hierarchical structures as well as the properties of the terms/classes respectively, and we compare the assignment of IPC codes to patents with the annotation of PubMed documents with MeSH terms.Our analysis shows a strong structural similarity of the hierarchies, but significant differences of terms and annotations. The low number of IPC class assignments and the lack of occurrences of class labels in patent texts imply that current patent search is severely limited. To overcome these limits, we evaluate a method for the automated assignment of additional classes to patent documents, and we propose a system for guided patent search based on the use of class co-occurrence information and external resources. PMID:23734562

  14. A Two-Term MEDLINE Search Strategy for Identifying Randomized Trials in Obstetrics and Gynecology

    Microsoft Academic Search

    Chika R Nwosu; Khalid S Khan; Patrick F. W Chien

    1998-01-01

    Objective: To develop and test a simple MEDLINE search strategy for identification of randomized controlled trials (RCTs) in obstetrics and gynecology.Methods: To develop our search strategy, we asked clinicians in our department to indicate, from a list of search terms, the terms they would use to identify RCTs in MEDLINE. The two most common terms, controlled-clinical-trial (publication type) and randomized-controlled-trial

  15. Precision and Recall of Search Strategies for Identifying Studies on Return-To-Work in Medline

    Microsoft Academic Search

    Jean-François Gehanno; Laetitia Rollin; Tony Le Jean; Alexandre Louvel; Stefan Darmoni; William Shaw

    2009-01-01

    Introduction The purpose of this study was to report on the qualities of various search strategies and keywords to find return to work\\u000a (RTW) studies in the Medline bibliographic database. Methods We searched Medline for articles on RTW published in 2003, using multiple search strings, and hand searched 16 major periodicals\\u000a of rehabilitation or occupational medicine. Among the retrieved articles,

  16. Pharmacy journal abstracts published in PubMed that abide by the CONsolidated Standards Of Reporting Trials (CONSORT) guidelines

    PubMed Central

    Blair, Daniel A.; Woolley, Thomas W.

    2014-01-01

    The purpose of this research was to determine the proportion of abstracts in pharmacy journals that are prepared according to the CONsolidated Standards Of Reporting Trials (CONSORT) criteria for abstracts. Certain abstracts for randomized controlled clinical trials (RCTs) indexed in PubMed were eligible for inclusion, with the primary endpoint being median overall compliance to CONSORT recommendations for abstracts. A total of 63 RCT abstracts were included in the analysis, with only 56% of the recommended CONSORT items represented in the sample. It is recommended that pharmacy journals encourage authors to follow CONSORT recommendations for abstracts when submitting RCTs for publication. PMID:24860268

  17. Carbon monoxide levels experienced by heavy smoker...[Inhal Toxicol. 2008] -PubMed Result Inhal Toxicol. 2008 May;20(7):635-46. Links

    E-print Network

    Brand, Paul H.

    Carbon monoxide levels experienced by heavy smoker...[Inhal Toxicol. 2008] - PubMed Result Inhal of long-term inhalation of carbon monoxide (CO) administrated to give concentrations in the blood similar

  18. In 2006, we performed an unbiased search of Pubmed for papers published on either synergistic or antagonistic interactions between antibiotics in vitro. We required the

    E-print Network

    Kishony, Roy

    of these links will open the Pubmed abstract in the default browser. Example: Penicillin's interaction with gentamycin. In the interests of clarity, I've created the subnetwork of penicillin and its interactions

  19. Screening women for intimate partner violence in healthcare settings: abridged Cochrane systematic review and meta-analysis

    PubMed Central

    2014-01-01

    Objective To examine the effectiveness of screening for intimate partner violence conducted within healthcare settings to determine whether or not screening increases identification and referral to support agencies, improves women’s wellbeing, decreases further violence, or causes harm. Design Systematic review and meta-analysis of trials assessing effectiveness of screening. Study assessment, data abstraction, and quality assessment were conducted independently by two of the authors. Standardised estimations of the risk ratios and 95% confidence intervals were calculated. Data sources Nine databases searched up to July 2012 (CENTRAL, Medline, Medline(R), Embase, DARE, CINAHL, PsycINFO, Sociological Abstracts, and ASSIA), and five trials registers searched up to 2010. Eligibility criteria for selecting studies Randomised or quasi-randomised trials of screening programmes for intimate partner violence involving all women aged ?16 attending a healthcare setting. We included only studies in which clinicians in the intervention arm personally conducted the screening, or were informed of the screening result at the time of the consultation, compared with usual care (or no screening). Studies of screening programmes that were followed by structured interventions such as advocacy or therapeutic intervention were excluded. Results 11 eligible trials (n=13?027) were identified. In six pooled studies (n=3564), screening increased the identification of intimate partner violence (risk ratio 2.33, 95% confidence interval 1.39 to 3.89), particularly in antenatal settings (4.26, 1.76 to 10.31). Based on three studies (n=1400), we detected no evidence that screening increases referrals to domestic violence support services (2.67, 0.99 to 7.20). Only two studies measured women’s experience of violence after screening (three to 18 months after screening) and found no reduction in intimate partner violence. One study reported that screening does not cause harm. Conclusions Though screening is likely to increase identification of intimate partner violence in healthcare settings, rates of identification from screening interventions were low relative to best estimates of prevalence of such violence. It is uncertain whether screening increases effective referral to supportive agencies. Screening does not seem to cause harm in the short term, but harm was measured in only one study. As the primary studies did not detect improved outcomes for women screened for intimate partner violence, there is insufficient evidence for screening in healthcare settings. Studies comparing screening versus case finding, or screening in combination with therapeutic intervention for women’s long term wellbeing, are needed to inform the implementation of identification policies in healthcare settings. PMID:24821132

  20. Comparisons of approaches to pelvic floor muscle training for urinary incontinence in women: an abridged Cochrane systematic review.

    PubMed

    Hay-Smith, J; Herderschee, R; Dumoulin, C; Herbison, P

    2012-12-01

    Pelvic floor muscle training (PFMT) is a first-line therapy for women with stress, urgency or mixed urinary incontinence (UI). Supervision and content of PFMT programmes is highly variable. The most effective approach to training is not known. The aim of the review was to compare the effects of different approaches to PFMT for women with UI. This was a systematic review with meta-analysis of randomized or quasi-randomized trials in women with stress, urgency or mixed UI that compared one approach to PFMT with another. The Cochrane Incontinence Group Specialised Trials Register (17 May 2011) was searched. Two reviewers independently assessed trials for eligibility and risk of bias, and extracted data. Data were analyzed as described in the Cochrane Handbook for Systematic Reviews of Interventions (version 5.2.2). From 574 records we included 21 trials (1490 women randomized) that addressed 11 comparisons. Comparisons made included: differences in training supervision (amount, individual versus group), in approach (one versus another, the effect of an additional component) and the exercise training (type of contraction, frequency of training). There were few trials or data in any comparison. In women with stress UI, 10% who received more health professional contact (weekly or twice-weekly group supervision plus individual appointments) did not report improvement compared to 43% who had individual appointments only (risk ratio for no improvement 0.29, 95% confidence interval 0.15 to 0.55, four trials). While women receiving more contact were more likely to report improvement, the confidence interval was wide, and more than half of "controls" reported improvement. This finding, of subjective improvement in both active treatment groups, with more improvement reported by those receiving more health professional contact, was consistent throughout the review. Considerable caution is needed in interpreting the results of the review. Existing evidence is insufficient to make any strong recommendations about the best approach to PFMT. A consistent pattern of more self-reported improvement with more health professional contact was observed; the few data consistently showed that women receiving regular (e.g. weekly) supervision were more likely to report improvement than women doing PFMT with little or no supervision. The clinical rehabilitation impact is to offer women reasonably frequent health professional contact during supervised PFMT. PMID:23183454

  1. Information Literacy for Users at the National Medical Library of Cuba: Cochrane Library Course for the Search of Best Evidence for Clinical Decisions

    ERIC Educational Resources Information Center

    Santana Arroyo, Sonia; del Carmen Gonzalez Rivero, Maria

    2012-01-01

    The National Medical Library of Cuba is currently developing an information literacy program to train users in the use of biomedical databases. This paper describes the experience with the course "Cochrane Library: Evidence-Based Medicine," which aims to teach users how to make the best use of this database, as well as the evidence-based medicine…

  2. Rate-Achievability Strategies for Two-Hop Interference Flows Chandrashekhar Thejaswi PS, Amir Bennatan, Junshan Zhang, Robert Calderbank and Douglas Cochran

    E-print Network

    Reisslein, Martin

    Rate-Achievability Strategies for Two-Hop Interference Flows Chandrashekhar Thejaswi PS, Amir Bennatan, Junshan Zhang, Robert Calderbank and Douglas Cochran Abstract-- We consider a basic model for two-hop simultaneously transmit to two relays (in the first hop), which then simultaneously transmit to two destinations

  3. Service Engagement in Interventions for Street-Connected Children and Young People: A Summary of Evidence Supplementing a Recent Cochrane-Campbell Review

    ERIC Educational Resources Information Center

    Hossain, Rosa; Coren, Esther

    2015-01-01

    Background: This paper builds on a Cochrane-Campbell systematic review of interventions that reduce harms and promote reintegration in street-connected children and young people focusing on intervention outcomes. The aim of the present analysis is to explore questions raised in the systematic review over the potential role of service engagement in…

  4. Pilot study optimizing MEDLINE queries in an automated disease management telemedicine system.

    PubMed Central

    Spaeder, Jeffrey A.

    2002-01-01

    Clinicians encounter many medical questions while providing outpatient medical care. A significant number of these questions can be answered using MEDLINE; however it has proven to be difficult to incorporate MEDLINE into routine clinical workflow and for clinicians to generate well constructed MEDLINE queries. This study however hypothesized that that well-constructed MEDLINE queries could be semi-automatically generated by an application named LitButton which was incorporated into the TeleWatch telemedicine system. The LitButton application was then prospectively evaluated in a pilot study by four nurse case managers (NCM) who monitored sixty-eight outpatients for three weeks. During this period the NCMs used the LitButton application sixteen times, and they subjectively reported in real-time that they obtained an answer in 56% of the cases, but that none of the successful information retrieval events resulted in a change in a patient's clinical management. The small number of LitButton events and lack of clinical impact was likely due to the fact that the LitButton function was designed to search MEDLINE for treatment related information; however the NCMs had limited medical decision making responsibilities. As a result there was a mismatch between the user's information needs and the system capabilities. PMID:12463918

  5. MeSH Speller + askMEDLINE: auto-completes MeSH terms then searches MEDLINE/PubMed via free-text, natural language queries.

    PubMed

    Fontelo, Paul; Liu, Fang; Ackerman, Michael

    2005-01-01

    Medical terminology is challenging even for healthcare personnel. Spelling errors can make searching MEDLINE/PubMed ineffective. We developed a utility that provides MeSH term and Specialist Lexicon Vocabulary suggestions as it is typed on a search page. The correctly spelled term can be incorporated into a free-text, natural language search or used as a clinical queries search. PMID:16779244

  6. Integrating personalized health information from MedlinePlus in a patient portal.

    PubMed

    Borbolla, Damian; Del Fiol, Guilherme; Taliercio, Vanina; Otero, Carlos; Campos, Fernando; Martinez, Marcela; Luna, Daniel; Quiros, Fernan

    2014-01-01

    The objective of this paper is to describe the implementation and use of context aware information in Spanish from MedlinePlus embedded in a Patient Portal. Personalized information can help patients solve problems, make treatment decisions, gain confidence in their ability to care for themselves and communicate with providers. To integrate MedlinePlus information in our institutional PHR we used the HL7 Context-Aware Knowledge Retrieval Standard, also known as the Infobutton Standard. After analysing one year of use, patients accessed MedlinePlus information in Spanish in a similar rate to other personalized information generated locally. Infobuttons associated to laboratory test results were used in approximately 10% of patients portal sessions when reviewing lab results. PMID:25160204

  7. The Match of Her Life | NIH MedlinePlus the Magazine

    MedlinePLUS

    ... lives. Now, she is emphasizing the importance for women to get regular, preventive health screenings for breast cancer. Navratilova recently made time to answer questions for this issue of NIH MedlinePlus magazine about her breast cancer. You discovered you had ...

  8. Automatic extraction of mutations from Medline and cross-validation with OMIM.

    PubMed

    Rebholz-Schuhmann, Dietrich; Marcel, Stephane; Albert, Sylvie; Tolle, Ralf; Casari, Georg; Kirsch, Harald

    2004-01-01

    Mutations help us to understand the molecular origins of diseases. Researchers, therefore, both publish and seek disease-relevant mutations in public databases and in scientific literature, e.g. Medline. The retrieval tends to be time-consuming and incomplete. Automated screening of the literature is more efficient. We developed extraction methods (called MEMA) that scan Medline abstracts for mutations. MEMA identified 24,351 singleton mutations in conjunction with a HUGO gene name out of 16,728 abstracts. From a sample of 100 abstracts we estimated the recall for the identification of mutation-gene pairs to 35% at a precision of 93%. Recall for the mutation detection alone was >67% with a precision rate of >96%. This shows that our system produces reliable data. The subset consisting of protein sequence mutations (PSMs) from MEMA was compared to the entries in OMIM (20,503 entries versus 6699, respectively). We found 1826 PSM-gene pairs to be in common to both datasets (cross-validated). This is 27% of all PSM-gene pairs in OMIM and 91% of those pairs from OMIM which co-occur in at least one Medline abstract. We conclude that Medline covers a large portion of the mutations known to OMIM. Another large portion could be artificially produced mutations from mutagenesis experiments. Access to the database of extracted mutation-gene pairs is available through the web pages of the EBI (refer to http://www.ebi. ac.uk/rebholz/index.html). PMID:14704350

  9. John W. Scott Health Sciences Library Limiting to Research Articles in OVID MEDLINE

    E-print Network

    MacMillan, Andrew

    the search: Qualitative Studies Filter MEDLINE FOCUSED and click on the selection box for it. Scroll up not need to be exhaustive. If you need to be exhaustive in your search for research articles, for example an exhaustive search. Perform your topic search and apply any basic limits such as language or publication year

  10. John W. Scott Health Sciences Library Limiting to Research Articles in Ovid MEDLINE

    E-print Network

    MacMillan, Andrew

    search. Perform your topic search and apply any basic limits like language or publication year. Scroll Filter MEDLINE FOCUSED and click on the selection box for this search. Scroll up or down to locate not need to be exhaustive. If you need to be exhaustive in your search for research articles, e.g if you

  11. Mapping Medline Papers, Genes, and Proteins Related to Melanoma Research Kevin W. Boyack

    E-print Network

    Börner, Katy

    Mapping Medline Papers, Genes, and Proteins Related to Melanoma Research Kevin W. Boyack , Ketan@indiana.edu} Abstract What is the structure of the research reported on melanoma? How has it evolved over the last 40 of the melanoma research field. 1. Introduction Given the explosive growth of biomedical databases, a large

  12. Evaluating MEDLINE on CD-ROM: An Overview of Field Tests in Library and Clinical Settings.

    ERIC Educational Resources Information Center

    Rapp, Barbara A.; And Others

    1990-01-01

    Presents an overview of the National Library of Medicine's 1988 field test and evaluation project on the use of MEDLINE products on CD-ROM. Results are summarized in the areas of user characteristics, search characteristics, user satisfaction, product features and costs, and impact on online searching. (10 references) (LRW)

  13. A Zipfian Model of an Automatic Bibliographic System: An Application to MEDLINE.

    ERIC Educational Resources Information Center

    Fedorowicz, Jane

    1982-01-01

    Derives the underlying structure of the Zipf distribution, with emphasis on its application to word frequencies in the inverted files of automatic bibliographic systems, and applies the Zipfian model to the National Library of Medicine's MEDLINE database. An appendix on the Zipfian mean and 12 references are included. (Author/JL)

  14. For Distinguished Public Service: Medical Library Association Honors FNLM and NIH MedlinePlus Magazine | NIH ...

    MedlinePLUS

    ... this page please turn Javascript on. For Distinguished Public Service: Medical Library Association Honors FNLM and NIH MedlinePlus Magazine Past Issues / Summer 2011 Table of Contents MLA President Ruth Holst presented FNLM ... Service Award at the MLA’s recent national conference. ...

  15. How to select publications on occupational health: the usefulness of Medline and the impact factor

    Microsoft Academic Search

    J F Gehanno; B. Thirion

    2000-01-01

    OBJECTIVESPublications in the field of occupational health appear in various journals, including those of other medical specialties. This complicates the follow up of literature for specialists in this field. On the basis of Medline and the impact factor, this diversity was assessed, and a cost effective method for selecting the most pertinent journals in the practice of occupational health was

  16. Using MEDLINE as a Knowledge Source for Disambiguating Abbreviations in Full-Text Biomedical Journal Articles

    E-print Network

    Yu, Hong

    records as a knowledge source for disambiguating abbreviations in full-text biomedical journal articlesUsing MEDLINE as a Knowledge Source for Disambiguating Abbreviations in Full-Text Biomedical Journal Articles Hong Yua , Won Kimb , Vasileios Hatzivassilogloua,c , W. John Wilburb a Department

  17. Optimal search strategies for detecting health services research studies in MEDLINE

    Microsoft Academic Search

    Nancy L. Wilczynski; R. Brian Haynes; John N. Lavis; Alexandra E. Arnold-Oatley

    Background: Evidence from health services research (HSR) is cur- rently thinly spread through many journals, making it difficult for health services researchers, managers and policy-makers to find research on clinical practice guidelines and the appropri- ateness, process, outcomes, cost and economics of health care services. We undertook to develop and test search terms to re- trieve from the MEDLINE database

  18. Automatic Term Identification by User Profile for Document Categorisation in Medline

    E-print Network

    Petrakis, Euripides G.M.

    information by user profile. 1 http://www.nlm.nih.gov/databases/databases medline.html 2 http://www.nlm.nih.gov/mesh 3 http://www.nlm.nih.gov/research/umls 4 http://mmtx.nlm.nih.gov #12;2 A. Hliaoutakis, E

  19. Mining MEDLINE: Postulating a Beneficial Role for Curcumin Longa in Retinal Diseases

    E-print Network

    Srinivasan, Padmini

    Mining MEDLINE: Postulating a Beneficial Role for Curcumin Longa in Retinal Diseases Padmini supporting the suggested connection between curcumin and retinal diseases. In particular, curcumin influ, the evidence suggests that curcumin may have a beneficial and therapeutic role in the context of these dis

  20. Presenting Evidence to Patients Online: What Do Web Users Think of Consumer Summaries of Cochrane Musculoskeletal Reviews?

    PubMed Central

    Santesso, Nancy; O'Connor, Annette M; Lott, Alison; Lindgaard, Gitte; Syrowatka, Ania; Graham, Ian D; Tugwell, Peter S

    2011-01-01

    Background The Internet has the potential to be an effective medium for delivering health care knowledge to consumers. While computer usability research makes recommendations about how to present Web-based information generally, there remains no clear guidance on how to present specific forms of health care research evidence online in a way that facilitates understanding and good health care decision making. Objective The two goals of this study were to describe the Cochrane Musculoskeletal Group’s (CMSG’s) process for developing online patient-focused summaries of systematic reviews and to evaluate the impressions of these summaries formed by users. Methods A process for summarizing the results of systematic reviews via consumer summaries has evolved over 15 years. An evaluation of this approach took the form of Internet surveys on the Arthritis Society of Canada website and surveys of members of the Canadian Arthritis Patient Alliance (CAPA). Respondents provided information on background, relationship to the decision, their satisfaction with and preparation for decision making, and suggestions for improvements to the summaries. Survey data were collected between August 1, 2005, and February 28, 2006. Results A total of 261 respondents completed the survey. The majority (226/261 or 87%) of respondents reported having an arthritis-related condition. The consumer summary approach was generally reviewed favorably by respondents, with most agreeing that the summary provided appropriate information (177/261 or 68%), would be useful to others (160/261 or 61%), was well laid out (159/261 or 61%), was easy to learn from (157/261 or 60%), and was useful to the reader (153/261 or 59%). Areas of potential improvement were indicated by relatively fewer respondents agreeing that they could easily find all the information they wanted (118/261 or 45%), by a substantial proportion being unable to judge whether the providers of the information are reliable (80/261 or 31%), and by a similar proportion being unable to determine whether the information presented was the best available (68/261 or 26%). Conclusions The CMSG has developed an approach to summarizing the results of often-technical systematic reviews into public-friendly consumer summaries. Our online survey showed that this approach was generally well liked but identified specific areas for improvement. Feedback from this survey will help to reshape and improve the current template for consumer summaries used by the CMSG. PMID:21247863

  1. Citation: Smyth, G. K., and Speed, T. P. (2003). Normalization of cDNA microarray data. Methods 31, 265-273. [PubMed ID 14597310

    E-print Network

    Smyth, Gordon K.

    2003-01-01

    Citation: Smyth, G. K., and Speed, T. P. (2003). Normalization of cDNA microarray data. Methods 31, 265-273. [PubMed ID 14597310] Normalization of cDNA Microarray Data Gordon K. Smyth1 and Terry Speed12 means to adjust microarray data for effects which arise from variation in the technology rather than

  2. PubMed Results -Print Preview http://www.ncbi.nlm.nih.gov/sites/entrez 1 of 3 1/14/08 11:02 AM

    E-print Network

    Casavant, Tom

    PubMed Results - Print Preview http://www.ncbi.nlm.nih.gov/sites/entrez 1 of 3 1/14/08 11:02 AMMed Results - Print Preview http://www.ncbi.nlm.nih.gov/sites/entrez 2 of 3 1/14/08 11:02 AM PMID: 17398335

  3. Worldwide access to evidence-based mental health literature: how useful is PubMed in Anglo-Saxon and non-Anglo-Saxon countries?

    PubMed

    Morlino, Massimo; Polese, Daniela; Bruni, Andrea; Renato, Bellinello

    2005-10-01

    The aim of this study was to verify the presence of cultural variety among the psychiatric journals available on PubMed, the major online tool for accessing literature. Data for analysis were taken from a survey of the world psychiatric journals indexed in Index Medicus 1999 (IM), the alphabetical list used by PubMed, and from the mean impact factor (IF) values of the journals. Approximately 80% of international psychiatric literature available on PubMed is published in Anglo-Saxon countries, especially in the USA (59.8% of the total). The widespread use of the English language (94.9% of all the journals) further stresses the dominance of the Anglo-Saxon cultural model, as do the mean IF values of Anglo-Saxon journals compared to non-Anglo-Saxon publications (3.252 vs. 1.693; P=0.0079). The under-representation of non-Anglo-Saxon cultural models on PubMed plays a negative role for bringing about a truly multicultural literature in psychiatry. PMID:16194251

  4. A Study of the Morpho-Semantic Relationship in Medline1

    PubMed Central

    Wilbur, W. John; Smith, Larry

    2014-01-01

    Morphological analysis as applied to English has generally involved the study of rules for inflections and derivations. Recent work has attempted to derive such rules from automatic analysis of corpora. Here we study similar issues, but in the context of the biological literature. We introduce a new approach which allows us to assign probabilities of the semantic relatedness of pairs of tokens that occur in text in consequence of their relatedness as character strings. Our analysis is based on over 84 million sentences from the MEDLINE database, over 2.3 million token types that occur in MEDLINE, and enables us to identify over 36 million token type pairs which have assigned probabilities of semantic relatedness of at least 0.7 based on their similarity as strings. The quality of these predictions is tested by two different manual evaluations and found to be good. PMID:24976874

  5. Searching for rehabilitation articles on MEDLINE and EMBASE. An example with cross-over design

    Microsoft Academic Search

    Silvia Minozzi; Vanna Pistotti; Marco Forni

    2000-01-01

    Objective: To analyze the usefulness of MEDLINE and EMBASE biomedical databases in rehabilitation and to identify descriptors and text words necessary to do a comprehensive search.Methods: We looked for articles published since 1990 relating to neurologic, orthopedic, respiratory, urologic, and rheumatologic rehabilitation. We looked for all descriptors and text words pertinent to rehabilitation and linked them with “cross-over.”Results: We found

  6. Identifying the Interaction between Genes and Gene Products Based on Frequently Seen Verbs in Medline Abstracts

    Microsoft Academic Search

    Takeshi Sekimizu; Hyun S. Park

    1998-01-01

    We have selected the most frequently seen verbs from raw texts made up of 1-million-words ofMedline abstracts, and we were able to identify (or bracket) noun phrases contained in the corpus,with a precision rate of 90%. Then, based on the noun-phrase-bracketted corpus, we tried tofind the subject and object terms for some frequently seen verbs in the domain. The precisionrate

  7. Medline Plus

    NSDL National Science Digital Library

    This site is a service of the U.S. National Library of Medicine and the National Institutes of Health. The site provides a variety of information about human health, including the health effects of common environmental toxins.

  8. The comparative recall of Google Scholar versus PubMed in identical searches for biomedical systematic reviews: a review of searches used in systematic reviews

    PubMed Central

    2013-01-01

    Background The usefulness of Google Scholar (GS) as a bibliographic database for biomedical systematic review (SR) searching is a subject of current interest and debate in research circles. Recent research has suggested GS might even be used alone in SR searching. This assertion is challenged here by testing whether GS can locate all studies included in 21 previously published SRs. Second, it examines the recall of GS, taking into account the maximum number of items that can be viewed, and tests whether more complete searches created by an information specialist will improve recall compared to the searches used in the 21 published SRs. Methods The authors identified 21 biomedical SRs that had used GS and PubMed as information sources and reported their use of identical, reproducible search strategies in both databases. These search strategies were rerun in GS and PubMed, and analyzed as to their coverage and recall. Efforts were made to improve searches that underperformed in each database. Results GS’ overall coverage was higher than PubMed (98% versus 91%) and overall recall is higher in GS: 80% of the references included in the 21 SRs were returned by the original searches in GS versus 68% in PubMed. Only 72% of the included references could be used as they were listed among the first 1,000 hits (the maximum number shown). Practical precision (the number of included references retrieved in the first 1,000, divided by 1,000) was on average 1.9%, which is only slightly lower than in other published SRs. Improving searches with the lowest recall resulted in an increase in recall from 48% to 66% in GS and, in PubMed, from 60% to 85%. Conclusions Although its coverage and precision are acceptable, GS, because of its incomplete recall, should not be used as a single source in SR searching. A specialized, curated medical database such as PubMed provides experienced searchers with tools and functionality that help improve recall, and numerous options in order to optimize precision. Searches for SRs should be performed by experienced searchers creating searches that maximize recall for as many databases as deemed necessary by the search expert. PMID:24360284

  9. Compared with what? An analysis of control-group types in Cochrane and Campbell reviews of psychosocial treatment efficacy with substance use disorders

    PubMed Central

    Karlsson, Patrik; Bergmark, Anders

    2015-01-01

    Abstract Background and Aims A crucial, but under-appreciated, aspect in experimental research on psychosocial treatments of substance use disorders concerns what kinds of control groups are used. This paper examines how the distinction between different control-group designs have been handled by the Cochrane and the Campbell Collaborations in their systematic reviews of psychosocial treatments of substance abuse disorders. Methods We assessed Cochrane and Campbell reviews (n?=?8) that were devoted to psychosocial treatments of substance use disorders. We noted what control groups were considered and analysed the extent to which the reviews provided a rationale for chosen comparison conditions. We also analysed whether type of control group in the primary studies influenced how the reviews framed the effects discussed and whether this was related to conclusions drawn. Results The reviews covered studies involving widely different control conditions. Overall, little attention was paid to the use of different control groups (e.g. head-to-head comparisons versus untreated controls) and what this implies when interpreting effect sizes. Seven of eight reviews did not provide a rationale for the choice of comparison conditions. Conclusions Cochrane and Campbell reviews of the efficacy of psychosocial interventions with substance use disorders seem to underappreciate that the use of different control-group types yields different effect estimates. Most reviews have not distinguished between different control-group designs and therefore have provided a confused picture regarding absolute and relative treatment efficacy. A systematic approach to treating different control-group designs in research reviews is necessary for meaningful estimates of treatment efficacy. PMID:25393504

  10. Evaluation of the Cochrane Collaboration’s tool for assessing the risk of bias in randomized trials: focus groups, online survey, proposed recommendations and their implementation

    PubMed Central

    2014-01-01

    Background In 2008, the Cochrane Collaboration introduced a tool for assessing the risk of bias in clinical trials included in Cochrane reviews. The risk of bias (RoB) tool is based on narrative descriptions of evidence-based methodological features known to increase the risk of bias in trials. Methods To assess the usability of this tool, we conducted an evaluation by means of focus groups, online surveys and a face-to-face meeting. We obtained feedback from a range of stakeholders within The Cochrane Collaboration regarding their experiences with, and perceptions of, the RoB tool and associated guidance materials. We then assessed this feedback in a face-to-face meeting of experts and stakeholders and made recommendations for improvements and further developments of the RoB tool. Results The survey attracted 380 responses. Respondents reported taking an average of between 10 and 60 minutes per study to complete their RoB assessments, which 83% deemed acceptable. Most respondents (87% of authors and 95% of editorial staff) thought RoB assessments were an improvement over past approaches to trial quality assessment. Most authors liked the standardized approach (81%) and the ability to provide quotes to support judgements (74%). A third of participants disliked the increased workload and found the wording describing RoB judgements confusing. The RoB domains reported to be the most difficult to assess were incomplete outcome data and selective reporting of outcomes. Authors expressed the need for more guidance on how to incorporate RoB assessments into meta-analyses and review conclusions. Based on this evaluation, recommendations were made for improvements to the RoB tool and the associated guidance. The implementation of these recommendations is currently underway. Conclusions Overall, respondents identified positive experiences and perceptions of the RoB tool. Revisions of the tool and associated guidance made in response to this evaluation, and improved provision of training, may improve implementation. PMID:24731537

  11. The aprotinin saga and the risks of conducting meta-analyses on small randomised controlled trials – a critique of a Cochrane review

    PubMed Central

    Rosén, Måns

    2009-01-01

    Background Aprotinin for reducing blood loss during coronary artery bypass surgery was withdrawn from the market after early termination of a large randomised controlled trial (RCT) showing excess mortality for patients receiving aprotinin compared to lysine analogues. Several meta-analyses of small RCTs did not show excess mortality and even indicated reduced mortality, while several observational studies showed excess mortality. The aim of this paper is to review the quality of the meta-analysis of a Cochrane report. Methods The 52 studies included in the meta-analysis of the Cochrane report were reviewed according to whether an objective to study mortality was formulated in advance, whether follow-up method or time were specified, and whether the study had statistical power to show any effect. Results The Cochrane report restricted the analysis to RCTs, but the largest study should not have been included given that it was a prospective observational study with 1 784 patients rather than an RCT. None of the RCTs had sufficient statistical power to detect differences in mortality. Most studies had fewer than 100 patients. Seven out of 51 RCTs had mortality outcome as one of their objectives. Only very few described follow-up method or time. Conclusion It is doubtful whether small studies should be included in meta-analyses if they do not have the purpose of studying the specified outcome and if the follow-up method or time are not adequately described. The aprotinin saga shows overconfidence in small RCTs of inferior quality compared to well-conducted observational studies. PMID:19228407

  12. EnzyMiner: automatic identification of protein level mutations and their impact on target enzymes from PubMed abstracts

    PubMed Central

    Yeniterzi, Süveyda; Sezerman, U?ur

    2009-01-01

    Background A better understanding of the mechanisms of an enzyme's functionality and stability, as well as knowledge and impact of mutations is crucial for researchers working with enzymes. Though, several of the enzymes' databases are currently available, scientific literature still remains at large for up-to-date source of learning the effects of a mutation on an enzyme. However, going through vast amounts of scientific documents to extract the information on desired mutation has always been a time consuming process. In this paper, therefore, we describe an unique method, termed as EnzyMiner, which automatically identifies the PubMed abstracts that contain information on the impact of a protein level mutation on the stability and/or the activity of a given enzyme. Results We present an automated system which identifies the abstracts that contain an amino-acid-level mutation and then classifies them according to the mutation's effect on the enzyme. In the case of mutation identification, MuGeX, an automated mutation-gene extraction system has an accuracy of 93.1% with a 91.5 F-measure. For impact analysis, document classification is performed to identify the abstracts that contain a change in enzyme's stability or activity resulting from the mutation. The system was trained on lipases and tested on amylases with an accuracy of 85%. Conclusion EnzyMiner identifies the abstracts that contain a protein mutation for a given enzyme and checks whether the abstract is related to a disease with the help of information extraction and machine learning techniques. For disease related abstracts, the mutation list and direct links to the abstracts are retrieved from the system and displayed on the Web. For those abstracts that are related to non-diseases, in addition to having the mutation list, the abstracts are also categorized into two groups. These two groups determine whether the mutation has an effect on the enzyme's stability or functionality followed by displaying these on the web. PMID:19758466

  13. [Medline criteria for scientific journals selection. Methodology and indicators. Application to Spanish medical journals paying special attention to public health].

    PubMed

    Delgado López-Cózar, Emilio; Ruiz-Pérez, Rafael; Jiménez-Contreras, Evaristo

    2006-01-01

    Due to the strict selection process applied to its indexed journals, Medline is the most prestigious database in the Health and medicine field. The aim of this paper is both to analyze its selection criteria and translate into indicators that can be applied to Spanish medical journals willing to enter the Index Medicus. Analysis samples and methodology to apply obtained from the five groups of criteria considered by Medline (namely, Scope and coverage, Quality of contents, Quality of editorial work, Production quality and Audience) are proposed. A list of qualitative and quantitative indicators related to the five groups of criteria used by Medline is presented; namely, journal scientific output in the national and international context of the discipline, citation, analysis of the editorial committees, the editorial process and the peer-review system, indicators on compliance with the Vancouver guidelines, journal layout and informational quality, attractiveness, audience, journal visibility and interest as regards Medline goals. PMID:17193815

  14. Adrenergic-?2 receptor polymorphism and athletic performance

    Microsoft Academic Search

    Vishnu Sarpeshkar; David J Bentley

    2010-01-01

    The focus of this review is to evaluate the influence of ?2-adrenergic receptor (ADRB2) polymorphism on human physiological function and in turn on athletic performance. A narrative review is conducted on available literature using MedLine, Pubmed and the Cochrane Library to document the location and function of ADRB2 receptors, and specifically to address the influence of genetic polymorphisms on cardiovascular,

  15. Good evidence for effectiveness of analgesics most commonly prescribed by UK dentists

    Microsoft Academic Search

    Lasse A Skoglund

    2005-01-01

    Data sourcesDental trials were sought among systematic reviews of randomised, double-blind studies of analgesics in acute pain, which were identified from the Cochrane Library, Biological Abstracts, MEDLINE, PubMed and the Oxford Pain Relief database.Data extraction and synthesisData were extracted independently by two reviewers. Dichotomous information from active and placebo treatments was used, first to calculate the statistical significance using relative

  16. Herbal medicine for depression, anxiety and insomnia: A review of psychopharmacology and clinical evidence

    Microsoft Academic Search

    Jerome Sarris; Alexander Panossian; Isaac Schweitzer; Con Stough; Andrew Scholey

    Research in the area of herbal psychopharmacology has increased markedly over the past decades. To date however, a comprehensive review of herbal antidepressant, anxiolytic and hypnotic psychopharmacology and applications in depression, anxiety and insomnia has been absent. A search of MEDLINE (PubMed), CINAHL, PsycINFO, and the Cochrane Library databases was conducted (up to February 21st 2011) on commonly used psychotropic

  17. Laparoscopic-assisted vaginal hysterectomy vs abdominal hysterectomy for benign disease: a meta-analysis of randomized controlled trials

    Microsoft Academic Search

    Yue-xiong Yi; Wei Zhang; Qi Zhou; Wan-ru Guo; Yu Su

    The objective of this meta-analysis was to assess whether laparoscopic-assisted vaginal hysterectomy achieves better clinical results compared with abdominal hysterectomy. Medline (PubMed), EMBASE, Web of Science, ProQuest, Cochrane Library and China Biological Medicine Database were searched to identify randomized controlled trials that compared laparoscopic-assisted vaginal hysterectomy with abdominal hysterectomy. Twenty-three trials were studied and the analysis was performed using Review

  18. Effect of fish oil on arrhythmias and mortality: systematic review

    Microsoft Academic Search

    Hernando León; Marcelo C Shibata; Soori Sivakumaran; Marlene Dorgan; Trish Chatterley; Ross T Tsuyuki

    2008-01-01

    Objective To synthesise the literature on the effects of fish oil—docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA)—on mortality and arrhythmias and to explore dose response and formulation effects.Design Systematic review and meta-analysis.Data sources Medline, Embase, the Cochrane Library, PubMed, CINAHL, IPA, Web of Science, Scopus, Pascal, Allied and Complementary Medicine, Academic OneFile, ProQuest Dissertations and Theses, Evidence-Based Complementary Medicine, and

  19. Are treatment targets for hypercholesterolemia evidence based? Systematic review and meta-analysis of randomised controlled trials

    Microsoft Academic Search

    Y. Lebenthal; A. Horvath; P. Dziechciarz; H. Szajewska; R. Shamir

    2010-01-01

    ObjectiveSearch for evidence supporting target age, level of intervention and target values for low-density lipoprotein (LDL) cholesterol levels in children with familial hypercholesterolemia.DesignSystematic review and meta-analysis. PubMed, Medline, CINAHL and Cochrane Reviews databases from 1966 to 2007 were searched for articles reporting statin therapy in children and adolescents aged 8–18 years. Retrieved articles were screened for double-blind randomised controlled trials

  20. Modular Semantic Tagging of Medline Abstracts and its Use in Inferring Regulatory Networks

    SciTech Connect

    Verhagen, Marc; Pustejovsky, James; Taylor, Ronald C.; Sanfilippo, Antonio P.

    2011-09-19

    We describe MedstractPlus, a resource for mining relations from the Medline bibliographic database that is currently under construction. It was built on the remains of Medstract, a previously created resource that included a biorelation server and an acronym database. MedstractPlus uses simple and scalable natural language processing modules to structure text, is designed with reusability and extendibility in mind, and adheres to the philosophy of the Linguistic Annotation Framework. We show how MedstractPlus has been used to provide seeds for a novel approach to inferring transcriptional regulatory networks from gene expression data.

  1. Survey of individual users of MEDLINE on the NLM system (Summary)

    NASA Astrophysics Data System (ADS)

    Fukushima, Translated By Isao; Kawano, Koreni

    In the past three years the number of individual health professionals who search with MEDLINE on the NLM system has increased dramatically. It is continuing to grow at the rate of over 200 users per month. In order to provide them with an online information retrieval service that individuals can use easily and effectively, NLM surveyed this growing end-user population by the questionnaire including 35 items such as their demographic characteristics, methods of access to the system, frequency of searching, search purpose, number of citations retrieved, use of information retrieved, and level of satisfaction with current system. This paper describes the results of this survey.

  2. Exploiting MeSH indexing in MEDLINE to generate a data set for word sense disambiguation

    PubMed Central

    2011-01-01

    Background Evaluation of Word Sense Disambiguation (WSD) methods in the biomedical domain is difficult because the available resources are either too small or too focused on specific types of entities (e.g. diseases or genes). We present a method that can be used to automatically develop a WSD test collection using the Unified Medical Language System (UMLS) Metathesaurus and the manual MeSH indexing of MEDLINE. We demonstrate the use of this method by developing such a data set, called MSH WSD. Methods In our method, the Metathesaurus is first screened to identify ambiguous terms whose possible senses consist of two or more MeSH headings. We then use each ambiguous term and its corresponding MeSH heading to extract MEDLINE citations where the term and only one of the MeSH headings co-occur. The term found in the MEDLINE citation is automatically assigned the UMLS CUI linked to the MeSH heading. Each instance has been assigned a UMLS Concept Unique Identifier (CUI). We compare the characteristics of the MSH WSD data set to the previously existing NLM WSD data set. Results The resulting MSH WSD data set consists of 106 ambiguous abbreviations, 88 ambiguous terms and 9 which are a combination of both, for a total of 203 ambiguous entities. For each ambiguous term/abbreviation, the data set contains a maximum of 100 instances per sense obtained from MEDLINE. We evaluated the reliability of the MSH WSD data set using existing knowledge-based methods and compared their performance to that of the results previously obtained by these algorithms on the pre-existing data set, NLM WSD. We show that the knowledge-based methods achieve different results but keep their relative performance except for the Journal Descriptor Indexing (JDI) method, whose performance is below the other methods. Conclusions The MSH WSD data set allows the evaluation of WSD algorithms in the biomedical domain. Compared to previously existing data sets, MSH WSD contains a larger number of biomedical terms/abbreviations and covers the largest set of UMLS Semantic Types. Furthermore, the MSH WSD data set has been generated automatically reusing already existing annotations and, therefore, can be regenerated from subsequent UMLS versions. PMID:21635749

  3. Automatically extracting sentences from Medline citations to support clinicians’ information needs

    PubMed Central

    Jonnalagadda, Siddhartha Reddy; Del Fiol, Guilherme; Medlin, Richard; Weir, Charlene; Fiszman, Marcelo; Mostafa, Javed; Liu, Hongfang

    2013-01-01

    Objective Online health knowledge resources contain answers to most of the information needs raised by clinicians in the course of care. However, significant barriers limit the use of these resources for decision-making, especially clinicians’ lack of time. In this study we assessed the feasibility of automatically generating knowledge summaries for a particular clinical topic composed of relevant sentences extracted from Medline citations. Methods The proposed approach combines information retrieval and semantic information extraction techniques to identify relevant sentences from Medline abstracts. We assessed this approach in two case studies on the treatment alternatives for depression and Alzheimer's disease. Results A total of 515 of 564 (91.3%) sentences retrieved in the two case studies were relevant to the topic of interest. About one-third of the relevant sentences described factual knowledge or a study conclusion that can be used for supporting information needs at the point of care. Conclusions The high rate of relevant sentences is desirable, given that clinicians’ lack of time is one of the main barriers to using knowledge resources at the point of care. Sentence rank was not significantly associated with relevancy, possibly due to most sentences being highly relevant. Sentences located closer to the end of the abstract and sentences with treatment and comparative predications were likely to be conclusive sentences. Our proposed technical approach to helping clinicians meet their information needs is promising. The approach can be extended for other knowledge resources and information need types. PMID:23100128

  4. Study of style effects on OCR errors in the MEDLINE database

    NASA Astrophysics Data System (ADS)

    Garrison, Penny; Davis, Diane L.; Andersen, Tim L.; Barney Smith, Elisa H.

    2005-01-01

    The National Library of Medicine has developed a system for the automatic extraction of data from scanned journal articles to populate the MEDLINE database. Although the 5-engine OCR system used in this process exhibits good performance overall, it does make errors in character recognition that must be corrected in order for the process to achieve the requisite accuracy. The correction process works by feeding words that have characters with less than 100% confidence (as determined automatically by the OCR engine) to a human operator who then must manually verify the word or correct the error. The majority of these errors are contained in the affiliation information zone where the characters are in italics or small fonts. Therefore only affiliation information data is used in this research. This paper examines the correlation between OCR errors and various character attributes in the MEDLINE database, such as font size, italics, bold, etc. and OCR confidence levels. The motivation for this research is that if a correlation between the character style and types of errors exists it should be possible to use this information to improve operator productivity by increasing the probability that the correct word option is presented to the human editor. We have determined that this correlation exists, in particular for the case of characters with diacritics.

  5. Study of style effects on OCR errors in the MEDLINE database

    NASA Astrophysics Data System (ADS)

    Garrison, Penny; Davis, Diane L.; Andersen, Tim L.; Barney Smith, Elisa H.

    2004-12-01

    The National Library of Medicine has developed a system for the automatic extraction of data from scanned journal articles to populate the MEDLINE database. Although the 5-engine OCR system used in this process exhibits good performance overall, it does make errors in character recognition that must be corrected in order for the process to achieve the requisite accuracy. The correction process works by feeding words that have characters with less than 100% confidence (as determined automatically by the OCR engine) to a human operator who then must manually verify the word or correct the error. The majority of these errors are contained in the affiliation information zone where the characters are in italics or small fonts. Therefore only affiliation information data is used in this research. This paper examines the correlation between OCR errors and various character attributes in the MEDLINE database, such as font size, italics, bold, etc. and OCR confidence levels. The motivation for this research is that if a correlation between the character style and types of errors exists it should be possible to use this information to improve operator productivity by increasing the probability that the correct word option is presented to the human editor. We have determined that this correlation exists, in particular for the case of characters with diacritics.

  6. Automatic identification of comparative effectiveness research from Medline citations to support clinicians’ treatment information needs

    PubMed Central

    Zhang, Mingyuan; Fiol, Guilherme Del; Grout, Randall W.; Jonnalagadda, Siddhartha; Medlin, Richard; Mishra, Rashmi; Weir, Charlene; Liu, Hongfang; Mostafa, Javed; Fiszman, Marcelo

    2014-01-01

    Online knowledge resources such as Medline can address most clinicians’ patient care information needs. Yet, significant barriers, notably lack of time, limit the use of these sources at the point of care. The most common information needs raised by clinicians are treatment-related. Comparative effectiveness studies allow clinicians to consider multiple treatment alternatives for a particular problem. Still, solutions are needed to enable efficient and effective consumption of comparative effectiveness research at the point of care. Objective Design and assess an algorithm for automatically identifying comparative effectiveness studies and extracting the interventions investigated in these studies. Methods The algorithm combines semantic natural language processing, Medline citation metadata, and machine learning techniques. We assessed the algorithm in a case study of treatment alternatives for depression. Results Both precision and recall for identifying comparative studies was 0.83. A total of 86% of the interventions extracted perfectly or partially matched the gold standard. Conclusion Overall, the algorithm achieved reasonable performance. The method provides building blocks for the automatic summarization of comparative effectiveness research to inform point of care decision-making. PMID:23920677

  7. Creating the first MedlinePlus "Go Local" service: lessons and recommendations from the evaluation of NC Health Info.

    PubMed

    Silbajoris, Christie; McDuffee, Diana; Olney, Cynthia

    2007-01-01

    NC Health Info is an online collection of North Carolina based health services Web sites that seamlessly links local health resources to topical health information on MedlinePlus, the National Library of Medicine's consumer health information Web site. NC Health Info was the first project to connect local resources with MedlinePlus in the "Go Local" initiative. As such, NC Health Info serves as a model for other states to follow in connecting their own local information with Medline- Plus. This paper describes the processes used and lessons learned during a year-long evaluation of NC Health Info. Evaluation results may be of interest and applicable to any existing or planned "Go Local" project. PMID:17522010

  8. Addition of Japanese terms to MEDLINE File-Service through JOIS-III

    NASA Astrophysics Data System (ADS)

    Hosoe, Takao; Sakagami, Yasuhiko; Kawano, Koreni

    This paper describes new service through JOIS-III(JICST Online Information System-III) which enabled English databases, MEDLINE, TOXLINE, and CANCERLIT, to search and output both with Japanese MeSH terms and with English MeSH terms by adding terms of MeSH translated into Japanese to these three files. In this paper, circumstances and background of this plan, cooperation of the work between JICST and The Japan Medical Library Association(JMLA) , fundamental conception and rules for translation of MeSH thesaurus terms into Japanese, practical translation work, search and output by JOIS-III using Japanese MeSH terms translated, relation between JOIS-III and Japanese version of MeSH in book style published by JMLA, and future issues are also described.

  9. Mining connections between chemicals, proteins, and diseases extracted from Medline annotations.

    PubMed

    Baker, Nancy C; Hemminger, Bradley M

    2010-08-01

    The biomedical literature is an important source of information about the biological activity and effects of chemicals. We present an application that extracts terms indicating biological activity of chemicals from Medline records, associates them with chemical name and stores the terms in a repository called ChemoText. We describe the construction of ChemoText and then demonstrate its utility in drug research by employing Swanson's ABC discovery paradigm. We reproduce Swanson's discovery of a connection between magnesium and migraine in a novel approach that uses only proteins as the intermediate B terms. We validate our methods by using a cutoff date and evaluate them by calculating precision and recall. In addition to magnesium, we have identified valproic acid and nitric oxide as chemicals which developed links to migraine. We hypothesize, based on protein annotations, that zinc and retinoic acid may play a role in migraine. The ChemoText repository has promise as a data source for drug discovery. PMID:20348023

  10. Students' search process and outcome in Medline in writing an essay for a class on evidence-based medicine

    Microsoft Academic Search

    Saila Huuskonen; Pertti Vakkari

    2008-01-01

    Purpose – The aim of this study is to explore to which extent searching by medical students in Medline produces information items useful for writing an essay measured by precision and relative recall as perceived by the students, the proportion of cited items, and their utilization on four dimensions of the essay writing task evaluated by external assessors. It also

  11. MedlinePlus 2012 User Survey Results: Which of the following best describes the highest level of education you have ...

    MedlinePLUS

    ... slide6.html Slide Index | Previous | Next Which of the following best describes the highest level of education you have completed? (MedlinePlus en español users only) To use the sharing features on this page, please enable JavaScript. ...

  12. The UC MELVYL MEDLINE System: A Pilot Project for Access to Journal Literature through an Online Catalog.

    ERIC Educational Resources Information Center

    Lynch, Clifford A.; Berger, Michael G.

    1989-01-01

    Describes a pilot project by the University of California to provide access to biomedical and health sciences literature through the integration of the MEDLINE database into the University's MELVYL online union catalog. The discussion covers the design, implementation and evaluation of the system, current planning efforts, and key technical and…

  13. John W. Scott Health Sciences Library, 2012 Searching for Systematic Reviews, Meta-Analyses and Practice Guidelines in Ovid MEDLINE

    E-print Network

    MacMillan, Andrew

    -Analyses and Practice Guidelines in Ovid MEDLINE Systematic Reviews and Meta-Analyses After entering subject terms the Publication Type limit. After entering subject terms, click on Additional Limits and locate the Publication Type menu. Select Meta-Analysis and click on Limit A Search. Practice Guidelines After entering subject

  14. John W. Scott Health Sciences Library, 2012 Searching for Systematic Reviews, Meta-Analyses and Practice Guidelines in EBSCO MEDLINE

    E-print Network

    MacMillan, Andrew

    -analyses, this can be done using the Publication Type limit. After entering subject terms, browse through the Search Guidelines After entering subject terms, browse through the Search Options panel and locate the Publication-Analyses and Practice Guidelines in EBSCO MEDLINE Systematic Reviews and Meta-Analyses After entering subject terms

  15. How much do you need: a randomised experiment of whether readers can understand the key messages from summaries of Cochrane Reviews without reading the full review

    PubMed Central

    Clarke, Mike

    2014-01-01

    Objective We explored whether readers can understand key messages without having to read the full review, and if there were differences in understanding between various types of summary. Design A randomised experiment of review summaries which compared understanding of a key outcome. Participants Members of university staff (n?=?36). Setting Universities on the island of Ireland. Method The Cochrane Review chosen examines the health impacts of the use of electric fans during heat waves. Participants were asked their expectation of the effect these would have on mortality. They were then randomly assigned a summary of the review (i.e. abstract, plain language summary, podcast or podcast transcription) and asked to spend a short time reading/listening to the summary. After this they were again asked about the effects of electric fans on mortality and to indicate if they would want to read the full Review. Main outcome measure Correct identification of a key review outcome. Results Just over half (53%) of the participants identified its key message on mortality after engaging with their summary. The figures were 33% for the abstract group, 50% for both the plain language and transcript groups and 78% for the podcast group. Conclusions The differences between the groups were not statistically significant but suggest that the audio summary might improve knowledge transfer compared to written summaries. These findings should be explored further using a larger sample size and with other reviews. PMID:25341445

  16. Mining characteristics of epidemiological studies from Medline: a case study in obesity

    PubMed Central

    2014-01-01

    Background The health sciences literature incorporates a relatively large subset of epidemiological studies that focus on population-level findings, including various determinants, outcomes and correlations. Extracting structured information about those characteristics would be useful for more complete understanding of diseases and for meta-analyses and systematic reviews. Results We present an information extraction approach that enables users to identify key characteristics of epidemiological studies from MEDLINE abstracts. It extracts six types of epidemiological characteristic: design of the study, population that has been studied, exposure, outcome, covariates and effect size. We have developed a generic rule-based approach that has been designed according to semantic patterns observed in text, and tested it in the domain of obesity. Identified exposure, outcome and covariate concepts are clustered into health-related groups of interest. On a manually annotated test corpus of 60 epidemiological abstracts, the system achieved precision, recall and F-score between 79-100%, 80-100% and 82-96% respectively. We report the results of applying the method to a large scale epidemiological corpus related to obesity. Conclusions The experiments suggest that the proposed approach could identify key epidemiological characteristics associated with a complex clinical problem from related abstracts. When integrated over the literature, the extracted data can be used to provide a more complete picture of epidemiological efforts, and thus support understanding via meta-analysis and systematic reviews. PMID:24949194

  17. Hybrid approach combining contextual and statistical information for identifying MEDLINE citation terms

    NASA Astrophysics Data System (ADS)

    Kim, In Cheol; Le, Daniel X.; Thoma, George R.

    2008-01-01

    There is a strong demand for developing automated tools for extracting pertinent information from the biomedical literature that is a rich, complex, and dramatically growing resource, and is increasingly accessed via the web. This paper presents a hybrid method based on contextual and statistical information to automatically identify two MEDLINE citation terms: NIH grant numbers and databank accession numbers from HTML-formatted online biomedical documents. Their detection is challenging due to many variations and inconsistencies in their format (although recommended formats exist), and also because of their similarity to other technical or biological terms. Our proposed method first extracts potential candidates for these terms using a rule-based method. These are scored and the final candidates are submitted to a human operator for verification. The confidence score for each term is calculated using statistical information, and morphological and contextual information. Experiments conducted on more than ten thousand HTML-formatted online biomedical documents show that most NIH grant numbers and databank accession numbers can be successfully identified by the proposed method, with recall rates of 99.8% and 99.6%, respectively. However, owing to the high false alarm rate, the proposed method yields F-measure rates of 86.6% and 87.9% for NIH grants and databanks, respectively.

  18. Computer searching of the medical literature. An evaluation of MEDLINE searching systems.

    PubMed

    Haynes, R B; McKibbon, K A; Walker, C J; Mousseau, J; Baker, L M; Fitzgerald, D; Guyatt, G; Norman, G R

    1985-11-01

    Although clinicians can now search the medical literature electronically from the clinic, bedside, or operating suite, little is known about the performance characteristics of online information services. Fourteen access routes to the MEDLINE database of journal literature were compared for retrieval quantity and quality, user and online search time, and cost for randomly ordered, standardized searches on common clinical problems. All routes produced the articles we judged to be the most definitive on the clinical problem. However, routes differed significantly (p less than 0.01) for the same searches with respect to online time (range, 5.15 to 18.72 minutes), total search time (8.37 to 20.55 minutes), cost (US $3.38 to $11.62), and proportion of articles relevant to the topic (98% to 75%). "User friendliness" aside, our results showed that the higher the cost, the worse the product. Clinicians should consider these major differences when deciding which search system to use. PMID:3901853

  19. Prophylactic cranial irradiation for preventing brain metastases in patients undergoing radical treatment for non-small-cell lung cancer: A Cochrane Review

    SciTech Connect

    Lester, Jason Francis [Department of Oncology, Velindre Hospital, Whitchurch, Cardiff, Wales (United Kingdom)]. E-mail: jason.lester@velindre-tr.wales.nhs.uk; MacBeth, Fergus R. [Department of Oncology, Velindre Hospital, Whitchurch, Cardiff, Wales (United Kingdom); Coles, Bernadette [Department of Oncology, Velindre Hospital, Whitchurch, Cardiff, Wales (United Kingdom)

    2005-11-01

    Purpose: To investigate whether prophylactic cranial irradiation (PCI) has a role in the management of patients with non-small-cell lung cancer (NSCLC) treated with curative intent. Methods and Materials: A search strategy was designed to identify randomized controlled trials (RCTs) comparing PCI with no PCI in NSCLC patients treated with curative intent. The electronic databases MEDLINE, EMBASE, LILACS, and Cancerlit were searched, along with relevant journals, books, and review articles to identify potentially eligible trials. Four RCTs were identified and reviewed. A total of 951 patients were randomized in these RCTs, of whom 833 were evaluable and reported. Forty-two patients with small-cell lung cancer were excluded, leaving 791 patients in total. Because of the small patient numbers and trial heterogeneity, no meta-analysis was attempted. Results: Prophylactic cranial irradiation did significantly reduce the incidence of brain metastases in three trials. No trial reported a survival advantage with PCI over observation. Toxicity data were poorly collected and no quality of life assessments were carried out in any trial. Conclusion: Prophylactic cranial irradiation may reduce the incidence of brain metastases, but there is no evidence of a survival benefit. It was not possible to evaluate whether any radiotherapy regimen is superior, and the effect of PCI on quality of life is not known. There is insufficient evidence to support the use of PCI in clinical practice. Where possible, patients should be offered entry into a clinical trial.

  20. Using MEDLINE as a knowledge source for disambiguating abbreviations and acronyms in full-text biomedical journal articles.

    PubMed

    Yu, Hong; Kim, Won; Hatzivassiloglou, Vasileios; Wilbur, W John

    2007-04-01

    Biomedical abbreviations and acronyms are widely used in biomedical literature. Since many of them represent important content in biomedical literature, information retrieval and extraction benefits from identifying the meanings of those terms. On the other hand, many abbreviations and acronyms are ambiguous, it would be important to map them to their full forms, which ultimately represent the meanings of the abbreviations. In this study, we present a semi-supervised method that applies MEDLINE as a knowledge source for disambiguating abbreviations and acronyms in full-text biomedical journal articles. We first automatically generated from the MEDLINE abstracts a dictionary of abbreviation-full pairs based on a rule-based system that maps abbreviations to full forms when full forms are defined in the abstracts. We then trained on the MEDLINE abstracts and predicted the full forms of abbreviations in full-text journal articles by applying supervised machine-learning algorithms in a semi-supervised fashion. We report up to 92% prediction precision and up to 91% coverage. PMID:16843731

  1. Global mapping of gene/protein interactions in PubMed abstracts: a framework and an experiment with P53 interactions.

    PubMed

    Li, Xin; Chen, Hsinchun; Huang, Zan; Su, Hua; Martinez, Jesse D

    2007-10-01

    Gene/protein interactions provide critical information for a thorough understanding of cellular processes. Recently, considerable interest and effort has been focused on the construction and analysis of genome-wide gene networks. The large body of biomedical literature is an important source of gene/protein interaction information. Recent advances in text mining tools have made it possible to automatically extract such documented interactions from free-text literature. In this paper, we propose a comprehensive framework for constructing and analyzing large-scale gene functional networks based on the gene/protein interactions extracted from biomedical literature repositories using text mining tools. Our proposed framework consists of analyses of the network topology, network topology-gene function relationship, and temporal network evolution to distill valuable information embedded in the gene functional interactions in the literature. We demonstrate the application of the proposed framework using a testbed of P53-related PubMed abstracts, which shows that the literature-based P53 networks exhibit small-world and scale-free properties. We also found that high degree genes in the literature-based networks have a high probability of appearing in the manually curated database and genes in the same pathway tend to form local clusters in our literature-based networks. Temporal analysis showed that genes interacting with many other genes tend to be involved in a large number of newly discovered interactions. PMID:17317333

  2. Randomized Controlled Trials of HIV/AIDS Prevention and Treatment in Africa: Results from the Cochrane HIV/AIDS Specialized Register

    PubMed Central

    Zani, Babalwa; Pienaar, Elizabeth D.; Oliver, Joy; Siegfried, Nandi

    2011-01-01

    Introduction To effectively address HIV/AIDS in Africa, evidence on preventing new infections and providing effective treatment is needed. Ideally, decisions on which interventions are effective should be based on evidence from randomized controlled trials (RCTs). Our previous research described African RCTs of HIV/AIDS reported between 1987 and 2003. This study updates that analysis with RCTs published between 2004 and 2008. Objectives To describe RCTs of HIV/AIDS conducted in Africa and reported between 2004 and 2008. Methods We searched the Cochrane HIV/AIDS Specialized Register in September 2009. Two researchers independently evaluated studies for inclusion and extracted data using standardized forms. Details included location of trials, interventions, methodological quality, location of principal investigators and funders. Results Our search identified 834 RCTs, with 68 conducted in Africa. Forty-three assessed prevention-interventions and 25 treatment-interventions. Fifteen of the 43 prevention RCTs focused on preventing mother-to-child HIV transmission. Thirteen of the 25 treatment trials focused on opportunistic infections. Trials were conducted in 16 countries with most in South Africa (20), Zambia (12) and Zimbabwe (9). The median sample size was 628 (range 33-9645). Methods used for the generation of the allocation sequence and allocation concealment were adequate in 38 and 32 trials, respectively, and 58 reports included a CONSORT recommended flow diagram. Twenty-nine principal investigators resided in the United States of America (USA) and 18 were from African countries. Trials were co-funded by different agencies with most of the funding obtained from USA governmental and non-governmental agencies. Nineteen pharmaceutical companies provided partial funding to 15 RCTs and African agencies co-funded 17 RCTs. Ethical approval was reported in 65 trials and informed consent in 61 trials. Conclusion Prevention trials dominate the trial landscape in Africa. Of note, few principal investigators and funders are from Africa. These findings mirror our previous work and continue to indicate a need for strengthening trial research capacity in Africa. PMID:22194905

  3. HIV/AIDS knowledge among female migrant farm worke...[J Immigr Health. 2003] -PubMed Result 1: J Immigr Health. 2003 Jan;5(1):29-36. Links

    E-print Network

    Abraham, Nader G.

    HIV/AIDS knowledge among female migrant farm worke...[J Immigr Health. 2003] - PubMed Result 1: J Immigr Health. 2003 Jan;5(1):29-36. Links HIV/AIDS knowledge among female migrant farm workers of Ohio, Toledo, Ohio 43614-5809, USA. The rate of HIV infection in the migrant farm worker community

  4. Citation: Smyth, G. K., Yang, Y.-H., Speed, T. P. (2003). Statistical issues in cDNA microarray data analysis. Methods in Molecular Biology 224, 111-136. [PubMed ID 12710670

    E-print Network

    Smyth, Gordon K.

    2003-01-01

    data analysis. Methods in Molecular Biology 224, 111-136. [PubMed ID 12710670] Statistical Issues in cCitation: Smyth, G. K., Yang, Y.-H., Speed, T. P. (2003). Statistical issues in cDNA microarray Institute of Medical Research 2. Department of Statistics, University of California, Berkeley Address

  5. PMD2HD – A web tool aligning a PubMed search results page with the local German Cancer Research Centre library collection

    PubMed Central

    Bohne-Lang, Andreas; Lang, Elke; Taube, Anke

    2005-01-01

    Background Web-based searching is the accepted contemporary mode of retrieving relevant literature, and retrieving as many full text articles as possible is a typical prerequisite for research success. In most cases only a proportion of references will be directly accessible as digital reprints through displayed links. A large number of references, however, have to be verified in library catalogues and, depending on their availability, are accessible as print holdings or by interlibrary loan request. Methods The problem of verifying local print holdings from an initial retrieval set of citations can be solved using Z39.50, an ANSI protocol for interactively querying library information systems. Numerous systems include Z39.50 interfaces and therefore can process Z39.50 interactive requests. However, the programmed query interaction command structure is non-intuitive and inaccessible to the average biomedical researcher. For the typical user, it is necessary to implement the protocol within a tool that hides and handles Z39.50 syntax, presenting a comfortable user interface. Results PMD2HD is a web tool implementing Z39.50 to provide an appropriately functional and usable interface to integrate into the typical workflow that follows an initial PubMed literature search, providing users with an immediate asset to assist in the most tedious step in literature retrieval, checking for subscription holdings against a local online catalogue. Conclusion PMD2HD can facilitate literature access considerably with respect to the time and cost of manual comparisons of search results with local catalogue holdings. The example presented in this article is related to the library system and collections of the German Cancer Research Centre. However, the PMD2HD software architecture and use of common Z39.50 protocol commands allow for transfer to a broad range of scientific libraries using Z39.50-compatible library information systems. PMID:15982415

  6. Network-based analysis reveals distinct association patterns in a semantic MEDLINE-based drug-disease-gene network

    PubMed Central

    2014-01-01

    Background A huge amount of associations among different biological entities (e.g., disease, drug, and gene) are scattered in millions of biomedical articles. Systematic analysis of such heterogeneous data can infer novel associations among different biological entities in the context of personalized medicine and translational research. Recently, network-based computational approaches have gained popularity in investigating such heterogeneous data, proposing novel therapeutic targets and deciphering disease mechanisms. However, little effort has been devoted to investigating associations among drugs, diseases, and genes in an integrative manner. Results We propose a novel network-based computational framework to identify statistically over-expressed subnetwork patterns, called network motifs, in an integrated disease-drug-gene network extracted from Semantic MEDLINE. The framework consists of two steps. The first step is to construct an association network by extracting pair-wise associations between diseases, drugs and genes in Semantic MEDLINE using a domain pattern driven strategy. A Resource Description Framework (RDF)-linked data approach is used to re-organize the data to increase the flexibility of data integration, the interoperability within domain ontologies, and the efficiency of data storage. Unique associations among drugs, diseases, and genes are extracted for downstream network-based analysis. The second step is to apply a network-based approach to mine the local network structure of this heterogeneous network. Significant network motifs are then identified as the backbone of the network. A simplified network based on those significant motifs is then constructed to facilitate discovery. We implemented our computational framework and identified five network motifs, each of which corresponds to specific biological meanings. Three case studies demonstrate that novel associations are derived from the network topology analysis of reconstructed networks of significant network motifs, further validated by expert knowledge and functional enrichment analyses. Conclusions We have developed a novel network-based computational approach to investigate the heterogeneous drug-gene-disease network extracted from Semantic MEDLINE. We demonstrate the power of this approach by prioritizing candidate disease genes, inferring potential disease relationships, and proposing novel drug targets, within the context of the entire knowledge. The results indicate that such approach will facilitate the formulization of novel research hypotheses, which is critical for translational medicine research and personalized medicine. PMID:25170419

  7. Research involving women and health in the Medline database, 1965–2005: co-term analysis and visualization of main lines of research

    Microsoft Academic Search

    M. Angeles Zulueta; Gisela Cantos-Mateos; Benjamín Vargas-Quesada; Carmen Sánchez

    This paper shows the main lines of research concerning health and women, as registered in the Medline database, broken down\\u000a into four 10-year periods: 1965–1974, 1975–1984, 1985–1994, and 1995–2005. The units of analysis used were the Medline “MeSH”\\u000a major terms, processed by means of co-term analysis. For graphic representation, the social network approach was used, with\\u000a pruning performed by Pathfinder

  8. A Meta-analysis of the effects of Exercise Training on Left Ventricular Remodeling Following Myocardial Infarction: Start early and go longer for greatest exercise benefits on remodeling

    Microsoft Academic Search

    Mark Haykowsky; Jessica Scott; Ben Esch; Don Schopflocher; Jonathan Myers; Ian Paterson; Darren Warburton; Lee Jones; Alexander M Clark

    2011-01-01

    Background  The effects of variations in exercise training on Left ventricular (LV) remodeling in patients shortly after Myocardial Infarction\\u000a (MI) are important but poorly understood.\\u000a \\u000a \\u000a \\u000a \\u000a Methods  Systematic review incorporating meta-analysis using meta-regression. Studies were identified via systematic searches of: OVID\\u000a MEDLINE (1950 to 2009), Cochrane Central Register of Controlled Trials (1991 to 2009), AMED (1985 to 2009), EMBASE (1988 to\\u000a 2009), PUBMED

  9. Are the pneumococcal polysaccharide vaccines effective? Meta-analysis of the prospective trials

    Microsoft Academic Search

    R Andrew Moore; Philip J Wiffen; Benjamin A Lipsky

    2000-01-01

    The objective was to review the evidence of effectiveness of the polyvalent polysaccharide pneumococcal vaccine from prospective\\u000a properly randomised controlled trials comparing pneumococcal vaccines with placebo in subjects who are immunocompetent and\\u000a those likely to have an impaired immune system.\\u000a \\u000a \\u000a Databases searched included the Cochrane Library, (issue 2, 2000), MEDLINE (1966-August 2000), PubMed (to August 2000) and\\u000a EMBASE ( to

  10. Academic Scientists' Reaction to End-User Services: Observations on a Trial Service Giving Access to MEDLINE Using the GRATEFUL MED Software.

    ERIC Educational Resources Information Center

    Tilson, Yvette; East, Harry

    1994-01-01

    Conducted at two British universities in 1993, a year-long trial service study of 20 bio-scientists using GRATEFUL MED software access to National Library of Medicine databases, principally MEDLINE, found that the users approved most of the service's ease, convenience, and time saving features and disapproved of its susceptibility to network…

  11. From Shakespeare to Star Trek and beyond: a Medline search for literary and other allusions in biomedical titles

    PubMed Central

    Goodman, Neville W

    2005-01-01

    Objectives To document biomedical paper titles containing literary and other allusions. Design Retrospective survey. Setting Medline (1951 to mid-2005) through Dialog Datastar. Main outcome measure Allusions to Shakespeare, Hans Christian Andersen, proverbs, the Bible, Lewis Carroll, and movie titles, corrected and scaled for five year periods 1950-4 to 2000-4. Results More than 1400 Shakespearean allusions exist, a third of them to “What's in a name” and another third to Hamlet—mostly to “To be or not to be.” The trend of increasing use of allusive titles, identified from Shakespeare and Andersen, is paralleled by allusions to Carroll and proverbs; the trend of biblical allusions is also upward but is more erratic. Trends for newer allusions are also upwards, including the previously surveyed “paradigm shift.” Allusive titles are likely to be to editorial or comment rather than to original research. Conclusions The similar trends are presumably a mark of a particular learnt author behaviour. Newer allusions may be becoming more popular than older ones. Allusive titles can be unhelpful to reviewers and researchers, and many are now clichés. Whether they attract readers or citations is unknown, but better ways of gaining attention exist. PMID:16373745

  12. Alignment of systematic reviews published in the Cochrane Database of Systematic Reviews and the Database of Abstracts and Reviews of Effectiveness with global burden-of-disease data: a bibliographic analysis

    PubMed Central

    Yoong, Sze Lin; Hall, Alix; Williams, Christopher M; Skelton, Eliza; Oldmeadow, Christopher; Wiggers, John; Karimkhani, Chante; Boyers, Lindsay N; Dellavalle, Robert P; Hilton, John; Wolfenden, Luke

    2015-01-01

    Background Systematic reviews of high-quality evidence are used to inform policy and practice. To improve community health, the production of such reviews should align with burden of disease. This study aims to assess if the volume of research output from systematic reviews proportionally aligns with burden of disease assessed using percentages of mortality and disability-adjusted life years (DALYs). Methods A cross-sectional audit of reviews published between January 2012 and August 2013 in the Cochrane Database of Systematic Reviews (CDSR) and Database of Abstracts of Reviews of Effects (DARE) was undertaken. Percentages of mortality and DALYs were obtained from the 2010 Global Burden of Disease study. Standardised residual differences (SRD) based on percentages of mortality and DALYs were calculated, where conditions with SRD of more than or less than three were considered overstudied or understudied, respectively. Results 1029 reviews from CDSR and 1928 reviews from DARE were examined. There was a significant correlation between percentage DALYs and systematic reviews published in CDSR and DARE databases (CDSR: r=0.68, p=0.001; DARE: r=0.60, p<0.001). There was no significant correlation between percentage mortality and number of systematic reviews published in either database (CDSR: r=0.34, p=0.14; DARE: r=0.22, p=0.34). Relative to percentage of mortality, mental and behavioural disorders, musculoskeletal conditions and other non-communicable diseases were overstudied. Maternal disorders were overstudied relative to percentages of mortality and DALYs in CDSR. Conclusions The focus of systematic reviews is moderately correlated with DALYs. A number of conditions may be overstudied relative to percentage of mortality particularly in the context of health and medical reviews. PMID:25888595

  13. Current Awareness Using PubMed

    Microsoft Academic Search

    Matthew Eberle

    2000-01-01

    Current awareness is something that librarians do, at least informally, passing on relevant current information to their patrons on a regular basis. The type of current awareness service considered here entails running preselected searches against electronic databases. The availability of these electronic bibliographic databases allows automating much of the current awareness process. Any successful current awareness service will have three

  14. Design and validation of an automated method to detect known adverse drug reactions in MEDLINE: a contribution from the EU–ADR project

    PubMed Central

    Avillach, Paul; Dufour, Jean-Charles; Diallo, Gayo; Salvo, Francesco; Joubert, Michel; Thiessard, Frantz; Mougin, Fleur; Trifirò, Gianluca; Fourrier-Réglat, Annie; Pariente, Antoine; Fieschi, Marius

    2013-01-01

    Objectives The aim of this research was to automate the search of publications concerning adverse drug reactions (ADR) by defining the queries used to search MEDLINE and by determining the required threshold for the number of extracted publications to confirm the drug/event association in the literature. Methods We defined an approach based on the medical subject headings (MeSH) ‘descriptor records’ and ‘supplementary concept records’ thesaurus, using the subheadings ‘chemically induced’ and ‘adverse effects’ with the ‘pharmacological action’ knowledge. An expert-built validation set of true positive and true negative drug/adverse event associations (n=61) was used to validate our method. Results Using a threshold of three of more extracted publications, the automated search method presented a sensitivity of 90% and a specificity of 100%. For nine different drug/event pairs selected, the recall of the automated search ranged from 24% to 64% and the precision from 93% to 48%. Conclusions This work presents a method to find previously established relationships between drugs and adverse events in the literature. Using MEDLINE, following a MeSH approach to filter the signals, is a valid option. Our contribution is available as a web service that will be integrated in the final European EU–ADR project (Exploring and Understanding Adverse Drug Reactions by integrative mining of clinical records and biomedical knowledge) automated system. PMID:23195749

  15. Selecting CD-ROM databases for nursing students: a comparison of MEDLINE and the Cumulative Index to Nursing and Allied Health Literature (CINAHL).

    PubMed Central

    Okuma, E

    1994-01-01

    With the introduction of the Cumulative Index to Nursing and Allied Health Literature (CINAHL) on CD-ROM, research was initiated to compare coverage of nursing journals by CINAHL and MEDLINE in this format, expanding on previous comparison of these databases in print and online. The study assessed search results for eight topics in 1989 and 1990 citations in both databases, each produced by SilverPlatter. Results were tallied and analyzed for number of records retrieved, unique and overlapping records, relevance, and appropriateness. An overall precision score was developed. The goal of the research was to develop quantifiable tools to help determine which database to purchase for an academic library serving an undergraduate nursing program. PMID:8136757

  16. BASIC DEFINITIONS TO ASSIST WITH UNDERSTANDING THE NIH PUBLIC ACCESS POLICY A database of citations and abstracts for biomedical literature from MEDLINE and additional life science journals. Links are provided

    E-print Network

    Grishok, Alla

    BASIC DEFINITIONS TO ASSIST WITH UNDERSTANDING THE NIH PUBLIC ACCESS POLICY PubMed A database number used when citing papers falling under the NIH Public Access Policy on applications, proposals in a journal. This number does NOT indicate compliance with the NIH Public Access Policy. NIH Public Access

  17. Such as MEDLINE (http://www.nlm.nih.gov) and SciSearch @LANL (http://scisearch2.lanl.gov). Such as the e-Print Arxiv @ LANL (http://xxx.lanl.gov/).

    E-print Network

    Rocha, Luis

    1 Such as MEDLINE (http://www.nlm.nih.gov) and SciSearch @LANL (http://scisearch2.lanl.gov). 2://laup.lanl.gov:4003/htmls/repquery.html). 4 Such as GenBank (http://www.ncbi.nlm.nih.gov/Genbank/) for Nucleic Acid

  18. Incidence of neoplasms in the most prevalent autoimmune rheumatic diseases: a systematic review.

    PubMed

    Machado, Roberta Ismael Lacerda; Braz, Alessandra de Sousa; Freire, Eutilia Andrade Medeiros

    2014-01-01

    This article is a systematic review of the literature about the coexistence of cancer and autoimmune rheumatic diseases, their main associations, cancers and possible risk factors associated, with emphasis on existing population-based studies, besides checking the relation of this occur with the use of the drugs used in the treatment of autoimmune diseases. A search was conducted of scientific articles indexed in the Cochrane / BVS, Pubmed / Medline and Scielo / Lilacs in the period from 2002 to 2012. Also consulted was the IB-ICT (Brazilian digital library of theses and Masters), with descriptors in Portuguese and English for "Systemic sclerosis", "Rheumatoid Arthritis", " Systemic Lupus Erythematosus" and "Sjögren's syndrome", correlating each one with the descriptor AND "neoplasms". The results showed that in the database IBICT a thesis and a dissertation for the descriptor SLE met the inclusion criteria, none met RA one thesis to SS. Lilacs in the database/Scielo found two articles on "Rheumatoid Arthritis" AND "neoplasms". In Pubmed/Medline the inicial search resulted in 118 articles, and 41 were selected. The review noted the relationship between cancer and autoimmune rheumatic diseases, as well as a risk factor for protection, although the pathophysiological mechanisms are not known. PMID:24878860

  19. Timing of cannulation of arteriovenous grafts: are we too cautious?

    PubMed Central

    Al Shakarchi, Julien; Inston, Nicholas

    2015-01-01

    Background Timing of first cannulation of an arteriovenous graft has been the subject of great debate for clinicians worldwide. In this paper, we reviewed the current literature on the timing of first cannulation of arteriovenous grafts. Methods Searches of PubMed, Medline and the Cochrane Library were performed using specific search terms to identify articles, dealing primarily with the timing of dialysis graft cannulation. Results Following strict inclusion/exclusion criteria by two reviewers, eleven studies were included and divided into subgroups for ePTFE and new generation grafts. Conclusions The current literature does not seem to support the current guidelines as there is no evidence to suggest that a delay in cannulation of grafts will improve graft survival and patency.

  20. Pharmacological treatments for frontotemporal dementias: a systematic review of randomized controlled trials.

    PubMed

    Nardell, Maria; Tampi, Rajesh R

    2014-03-01

    The objective of this review is to summarize the current data on the pharmacological treatments for frontotemporal dementias from randomized controlled trials. A systematic search of 4 major databases, PubMed, Medline, PsychINFO and Cochrane, found a total of 9 randomized controlled, double-blinded clinical trials. Of these, 2 trials used the selective serotonin reuptake inhibitor (SSRI), paroxetine; 1 trial used trazodone; 2 trials used stimulants (methylphenidate and dextroamphetamine); 1 trial used the acetylcholinesterase inhibitor, galantamine; 2 trials used the N-methyl-d-aspartate antagonist, memantine; and 1 trial used the neuropeptide oxytocin. The analysis of the available data indicates that SSRIs, trazodone, and the amphetamines may be effective in reducing some behavioral symptoms, but none of these medications had an impact on cognition. Available data indicate that these medications were well tolerated in all the trials. PMID:24164931

  1. Acupuncture for patients with Alzheimer's disease: a systematic review protocol

    PubMed Central

    Zhou, Jing; Peng, Weina; Li, Wang; Liu, Zhishun

    2014-01-01

    Introduction The aim of this protocol is to provide the methods used to assess the effectiveness and safety of acupuncture for the treatment of patients with Alzheimer's disease. Methods and analysis We will search the following electronic databases: The Cochrane Library, PubMed, Medline, Embase, PsycINFO, Chinese Biomedical Literature Database, Chinese Medical Current Contents and China National Knowledge Infrastructure without restriction of language and publication status. Other sources such as Chinese acupuncture journals and the reference list of selected studies will also be searched. After screening the studies, a meta-analysis of randomised controlled trials will be conducted, if possible. Results expressed as risk ratios for dichotomous data and standardised or weighted mean differences for continuous data, will be used for data synthesis. Dissemination The protocol of this systematic review will be disseminated in a peer-reviewed journal and presented at a relevant conference. Trial registration number PROSPERO CRD42014009619 PMID:25142265

  2. Nanotechnology and its Application in Dentistry

    PubMed Central

    Abiodun-Solanke, IMF; Ajayi, DM; Arigbede, AO

    2014-01-01

    Nanotechnology influences almost every facet of everyday life from security to medicine. The concept of nanotechnology is that when one goes down to the bottom of things, one can discover unlimited possibilities and potential of the basic particle. In nanotechnology, analysis can be made to the level of manipulating atoms, molecules and chemical bonds between them. The growing interest in the dental applications of nanotechnology is leading to the emergence of a new field called nanodentistry. An electronic database search that included PubMed, MedLine, and Cochrane library was conducted. Key words used in the search are nanotechnology dentistry and applications. Language limitation was set as articles reviewed were only those written and published in English language. We did not search the gray literature. Initially, 52 articles were retrieved from the database, and articles considered were those published from 2008 to 2013. Eight articles that met the selection criteria were eventually selected and reviewed. PMID:25364585

  3. [Treatment of rheumatic patients in a warm climate abroad].

    PubMed

    Forseth, Karin Øien

    2007-02-15

    Adult rheumatic and psoriatic patients in Norway have been offered state-funded treatment in a warm climate since 1976. The offer has since then been extended to other patient groups with chronic diseases. We here present a program, which mainly consists of intensive physical treatment in a warm, sunny and dry climate, for adults with chronic rheumatic disease. The article is based on available statistics and literature found by searching Medline, PubMed and Cochrane. Patients are selected for the program according to diagnosis, physical function and disease severity and activity. The majority of the patients have rheumatoid arthritis, ankylosing spondylitis or psoriatic arthritis. The treatment is demanding and is not suitable for all. There are two closing dates for applications, 1. October and 1. February. PMID:17304274

  4. Nanotechnology and its application in dentistry.

    PubMed

    Abiodun-Solanke, Imf; Ajayi, Dm; Arigbede, Ao

    2014-09-01

    Nanotechnology influences almost every facet of everyday life from security to medicine. The concept of nanotechnology is that when one goes down to the bottom of things, one can discover unlimited possibilities and potential of the basic particle. In nanotechnology, analysis can be made to the level of manipulating atoms, molecules and chemical bonds between them. The growing interest in the dental applications of nanotechnology is leading to the emergence of a new field called nanodentistry. An electronic database search that included PubMed, MedLine, and Cochrane library was conducted. Key words used in the search are nanotechnology dentistry and applications. Language limitation was set as articles reviewed were only those written and published in English language. We did not search the gray literature. Initially, 52 articles were retrieved from the database, and articles considered were those published from 2008 to 2013. Eight articles that met the selection criteria were eventually selected and reviewed. PMID:25364585

  5. Acupuncture for symptom management in cancer care: an update.

    PubMed

    Garcia, M Kay; McQuade, Jennifer; Lee, Richard; Haddad, Robin; Spano, Michael; Cohen, Lorenzo

    2014-12-01

    In a previous systematic review of the worldwide literature of randomized controlled trials (RCTs) involving needle insertion into acupuncture points for symptom management in cancer patients, we identified only one high-quality RCT that was deemed to have a low risk of bias. Medline, Embase, CINAHL, Cochrane (all databases), Scopus, and PubMed were searched from inception through December 2011 with no language limits applied. A total of 41 RCTs met all inclusion criteria and were rated. In the current review, we examined 18 trials published since our last report. The purpose of this update was to emphasize important recent findings and discuss how concerns such as blinding, separating non-specific placebo effects from specific needling effects, determining biologic mechanisms and dosing parameters, evaluating determinants of response such as expectation, controlling for sources of bias, and the lack of standardization in treatment and study methods may affect the interpretation of study results. PMID:25325937

  6. Disciplinary processes and the management of poor performance among UK nurses: bad apple or systemic failure? A scoping study.

    PubMed

    Traynor, Michael; Stone, Katie; Cook, Hannah; Gould, Dinah; Maben, Jill

    2014-03-01

    The rise of managerialism within healthcare systems has been noted globally. This paper uses the findings of a scoping study to investigate the management of poor performance among nurses and midwives in the United Kingdom within this context. The management of poor performance among clinicians in the NHS has been seen as a significant policy problem. There has been a profound shift in the distribution of power between professional and managerial groups in many health systems globally. We examined literature published between 2000 and 10 to explore aspects of poor performance and its management. We used Web of Science, CINAHL, MEDLINE, British Nursing Index, HMIC, Cochrane Library and PubMed. Empirical data are limited but indicate that nurses and midwives are the clinical groups most likely to be suspended and that poor performance is often represented as an individual deficit. A focus on the individual as a source of trouble can serve as a distraction from more complex systematic problems. PMID:23441729

  7. High Burden of Protein–Energy Malnutrition in Nigeria: Beyond the Health Care Setting

    PubMed Central

    Ubesie, AC; Ibeziakor, NS

    2012-01-01

    There is still a high burden of protein–energy malnutrition in Nigeria. The severe forms of the disease are usually associated with high level of mortality even in the tertiary health facilities. To review the cost-effective health promotional strategies at community levels that could aid prevention, early detection, and prompt treatment of protein–energy malnutrition. The strategy used for locating articles used for this review was to search databases like Google, Google scholar, relevant electronic journals from the universities’ libraries, including PubMed and Scirus, Medline, Cochrane library and WHO's Hinari. We believe that strategies beyond the health care setting have potential of significantly reducing the morbidity and mortality associated with protein–energy malnutrition in Nigeria. PMID:23209994

  8. Are women with a history of abuse more vulnerable to perinatal depressive symptoms? A systematic review.

    PubMed

    Alvarez-Segura, M; Garcia-Esteve, L; Torres, A; Plaza, A; Imaz, M L; Hermida-Barros, L; San, L; Burtchen, N

    2014-10-01

    The objective of this paper is to examine the association between maternal lifetime abuse and perinatal depressive symptoms. Papers included in this review were identified through electronic searches of the following databases: Pubmed Medline and Ovid, EMBASE, PsycINFO, and the Cochrane Library. Each database was searched from its start date through 1 September 2011. Keywords such as "postpartum," "perinatal," "prenatal," "depression," "violence," "child abuse," and "partner abuse" were included in the purview of MeSH terms. Studies that examined the association between maternal lifetime abuse and perinatal depression were included. A total of 545 studies were included in the initial screening. Forty-three articles met criteria for inclusion and were incorporated in this review. Quality of articles was evaluated with the Newcastle-Ottawa-Scale (NOS). This systematic review indicates a positive association between maternal lifetime abuse and depressive symptoms in the perinatal period. PMID:25005865

  9. An Evidence-Based Review of Fat Modifying Supplemental Weight Loss Products

    PubMed Central

    Egras, Amy M.; Hamilton, William R.; Lenz, Thomas L.; Monaghan, Michael S.

    2011-01-01

    Objective. To review the literature on fat modifying dietary supplements commonly used for weight loss. Methods. Recently published randomized, placebo-controlled trials were identified in PubMed, MEDLINE, International Pharmaceutical Abstracts, Cochrane Database, and Google Scholar using the search terms dietary supplement, herbal, weight loss, obesity, and individual supplement names. Discussion. Data for conjugated linoleic acid (CLA), Garcinia cambogia, chitosan, pyruvate, Irvingia gabonensis, and chia seed for weight loss were identified. CLA, chitosan, pyruvate, and Irvingia gabonensis appeared to be effective in weight loss via fat modifying mechanisms. However, the data on the use of these products is limited. Conclusion. Many obese people use dietary supplements for weight loss. To date, there is little clinical evidence to support their use. More data is necessary to determine the efficacy and safety of these supplements. Healthcare providers should assist patients in weighing the risks and benefits of dietary supplement use for weight loss. PMID:20847896

  10. Preventive Treatments of Iron Deficiency Anaemia in Pregnancy: A Review of Their Effectiveness and Implications for Health System Strengthening

    PubMed Central

    Osungbade, Kayode O.; Oladunjoye, Adeolu O.

    2012-01-01

    Objectives. We conducted a review of effectiveness of preventive treatments of iron deficiency anaemia in pregnancy in developing countries and highlighted their constraints as well as interventions required to strengthen the health services. Methods. Literature from Pubmed (MEDLINE), AJOL, Google Scholar, and Cochrane database was reviewed. Results. Evidence-based preventive treatment options for iron deficiency anaemia in pregnancy include prophylaxis iron supplements and food fortification with iron. Evidence abounds on their effectiveness in reducing the prevalence of iron deficiency anaemia in pregnancy. However, these prospects are threatened by side effects of iron supplements, low utilization of maternal health service in developing countries, partial implementation of preventive treatments, and weak infrastructure and political commitment to implement mass fortification of local staple foods by national governments. Conclusion. Sustainability of effectiveness of preventive treatments of iron deficiency anaemia in pregnancy could be achieved if the identified threats are adequately addressed. PMID:22848829

  11. An evidence-based review of fat modifying supplemental weight loss products.

    PubMed

    Egras, Amy M; Hamilton, William R; Lenz, Thomas L; Monaghan, Michael S

    2011-01-01

    Objective. To review the literature on fat modifying dietary supplements commonly used for weight loss. Methods. Recently published randomized, placebo-controlled trials were identified in PubMed, MEDLINE, International Pharmaceutical Abstracts, Cochrane Database, and Google Scholar using the search terms dietary supplement, herbal, weight loss, obesity, and individual supplement names. Discussion. Data for conjugated linoleic acid (CLA), Garcinia cambogia, chitosan, pyruvate, Irvingia gabonensis, and chia seed for weight loss were identified. CLA, chitosan, pyruvate, and Irvingia gabonensis appeared to be effective in weight loss via fat modifying mechanisms. However, the data on the use of these products is limited. Conclusion. Many obese people use dietary supplements for weight loss. To date, there is little clinical evidence to support their use. More data is necessary to determine the efficacy and safety of these supplements. Healthcare providers should assist patients in weighing the risks and benefits of dietary supplement use for weight loss. PMID:20847896

  12. Surgery Videos: MedlinePlus

    MedlinePLUS

    ... Injuries and Disorders Total Ankle Replacement (Doctors Hospital, Coral Gables, FL, 11/27/2012) Back Pain Lumbar ... 09/19/2007) Rotator Cuff Repair (Doctors Hospital, Coral Gables, FL, 6/18/2008) Shoulder Arthroscopy (St. ...

  13. Medical Encyclopedia: MedlinePlus

    MedlinePLUS

    ... this page, please enable JavaScript. The A.D.A.M. Medical Encyclopedia includes over 4,000 articles about ... and illustrations. For more information about A.D.A.M., see its content review board . Find encyclopedia articles ...

  14. Curriculum Vitae D. Liane Cochran-Stafira, Ph.D.

    E-print Network

    Cochran-Stafira, D. Liane

    Adaptation and Diversity; Botany; Biology of Algae; Aquatic Biology; Invertebrate Biology; Evolution: Process Biology; Bacteriology (for nurses); Human Anatomy and Physiology (for nurses) Research Interests: Community ecology Evolutionary Ecology Metacommunity dynamics Genotypic and phenotypic diversity

  15. Systematic review and meta-analysis of closed suction drainage versus non-drainage in primary hip arthroplasty.

    PubMed

    Kelly, Enda G; Cashman, James P; Imran, Farrah H; Conroy, Ronán; O'Byrne, John

    2014-03-01

    The routine use of drains in surgery has been dogmatically instituted in some disciplines. Orthopaedic surgery is one such sub-speciality. The use of postoperative closed suction drainage in total hip arthroplasty (THA) has become increasingly controversial with multiple randomised control trials performed to assess the benefit to outcome in THA. The hypothesis of this systematic review is that closed suction drainage does not infer a benefit and increase transfusion requirements of primary total hip arthroplasty patients. A systematic review and meta-analysis was conducted adhering to the PRISMA guidelines. A search of the available literature was performed on PubMed, Cochrane Central Registry of Controlled Trials, MEDLINE (OVID) and EMBASE using a combination of MeSH terms and Boolean operators. All data analysis was performed using the Cochrane Collaboration's Review Manager 5.1. Sixteen studies (n=2705) were included in the analysis. Post-operative closed suction drainage was found to increase total blood loss and blood transfusion requirements (p<0.05). Surgical site infection demonstrated no significant difference between the two groups (p=0.82). No significant difference in haematoma formation between groups (p=0.19) was elicited. The routine use of closed suction drainage systems post primary hip arthroplasty is not supported by this meta-analysis. However, the heterogeneity between studies does limit the accuracy of the meta-analysis. PMID:24574017

  16. A Comparison of the Efficacy and Safety of Non-Steroidal Anti-Inflammatory Drugs versus Acetaminophen in Symptom Relief for the Common Cold: A Meta-Analysis of Randomized Controlled Trial Studies

    PubMed Central

    Choi, Il-Kwon; Lee, Hyun-Keun; Ji, Young-Jung; Hwang, In-Hong

    2013-01-01

    Background Non-steroidal anti-inflammatory drugs (NSAIDs) and acetaminophen are widely used for common cold symptom relief. The objective of this study was to evaluate and compare the efficacy and safety of acetaminophen and NSAIDs in common cold symptom relief using meta-analysis of randomized controlled trial. Methods We searched MEDLINE (PubMed), Cochrane, EMBASE, CINAHL, KMbase, KoreaMed, National Assembly Library, and Riss4u for studies released through June 2012. Two authors independently extracted the data. To assess the risk of bias, the Cochrane Collaborations risk of bias tool was used. The Review Manager ver. 5.1 (RevMan) was used for statistics. Results We identified 5 studies. The relative benefit for participants with pain relief was 1.00 (95% confidence interval [CI], 0.96 to 1.05) and I2 = 0%. The existence of the heterogeneity between studies was not important in this study, thus subgroup analysis was not implemented. The relative benefit for participants with rhinorrhea was 1.02 (95% CI, 0.77 to 1.35) and I2 = 0%, which also indicates the existence of heterogeneity was not important. The relative risk of adverse events was 1.14 (95% CI, 0.93 to 1.40), I2 = 0%. There was no apparent asymmetry in the funnel plot. Conclusion There was no difference between NSAIDs and acetaminophen in common cold symptom relief. PMID:23904953

  17. Sublingual immunotherapy in children with allergic rhinitis: quality of systematic reviews.

    PubMed

    de Bot, Cindy M A; Moed, Heleen; Berger, Marjolein Y; Röder, Esther; van Wijk, Roy G; van der Wouden, Johannes C

    2011-09-01

    Systematic reviews have gained popularity as a way to combine the increasing amount of research information. This study assessed the quality of systematic reviews and meta-analyses of sublingual immunotherapy (SLIT) for allergic rhinitis in children, published since 2000. Eligible reviews were identified by searching Medline/Pubmed, Embase, and the Cochrane Library, from 2000 through 2008. Methodological quality was assessed using the assessment of multiple systematic reviews instrument. Ten systematic reviews were included, one of which was published in the Cochrane Library. Eight reviews gave some details about the search strategy. None of the reviews included measures to avoid selection bias. In 60% of the reviews, the methodological quality of the included studies was (partly) assessed. Four reviews pooled the results of individual studies, neglecting clinical heterogeneity. Three of the 10 reviews provided information about sources of funding or grants from industry. Of the 10 reviews, the six reviews with the highest overall score scored 5-8 points, indicating moderate quality. Systematic reviews are useful to evaluate the efficacy of SLIT in children. Although more reviews have become available, the methodological quality could be improved. SLIT for children could be promising, but methodological flaws in the reviews and individual studies are too serious to draw definite conclusions. PMID:21919934

  18. Describing methods and interventions: a protocol for the systematic analysis of the perioperative quality improvement literature

    PubMed Central

    2014-01-01

    Background Quality improvement (QI) methods are widely used in surgery in an effort to improve care, often using techniques such as Plan-Do-Study-Act cycles to implement specific interventions. Explicit definition of both the QI method and quality intervention is necessary to enable the accurate replication of effective interventions in practice, facilitate cumulative learning, reduce research waste and optimise benefits to patients. This systematic review aims to assess quality of reporting of QI methods and quality interventions in perioperative care. Methods Studies reporting on quality interventions implemented in perioperative care settings will be identified. Searches will be conducted in the Ovid SP version of Medline, Scopus, the Cochrane Central Register of Controlled Trials, the Cochrane Effective Practice and Organisation of Care database and the related articles function of PubMed. The journal BMJ Quality will be searched separately. Search strategy terms will relate to (i) surgery, (ii) QI and (iii) evaluation methods. Explicit exclusion and inclusion criteria will be applied. Data from studies will be extracted using a data extraction form. The Template for Intervention Description and Replication (TIDieR) checklist will be used to evaluate quality of reporting, together with additional items aimed at assessing QI methods specifically. Systematic review registration PROSPERO http://CRD42014012845 PMID:25193066

  19. A systematic review of surgical ablation versus catheter ablation for atrial fibrillation

    PubMed Central

    Kearney, Katherine; Stephenson, Rowan; Phan, Kevin; Chan, Wei Yen; Huang, Min Yin

    2014-01-01

    Background Atrial fibrillation (AF) is an increasingly prevalent condition in the ageing population, with significantly associated morbidity and mortality. Surgical and catheter ablative strategies both aim to reduce mortality and morbidity through freedom from AF. This review consolidates all currently available comparative data to evaluate these two interventions. Methods A systematic search was conducted across MEDLINE, PubMed, Embase, Cochrane Central Register of Controlled Trials and the Cochrane Database of Systematic Reviews from January 2000 until August 2013. All studies were critically appraised and only those directly comparing surgical and catheter ablation were included. Results Seven studies were deemed suitable for analysis according to the inclusion criteria. Freedom from AF was significantly higher in the surgical ablation group versus the catheter ablation group at 6-month, 12-month and study endpoint follow-up periods. Subgroup analysis demonstrated similar trends, with higher freedom from AF in the surgical ablation group for paroxysmal AF patients. The incidence of pacemaker implantation was higher, while no difference in stroke or cardiac tamponade was demonstrated for the surgical versus catheter ablation groups. Conclusions Current evidence suggests that epicardial ablative strategies are associated with higher freedom from AF, higher pacemaker implantation rates and comparable neurological complications and cardiac tamponade incidence to catheter ablative treatment. Other complications and risks were poorly reported, which warrants further randomized controlled trials (RCTs) of adequate power and follow-up duration. PMID:24516794

  20. Prospective Head and Neck Cancer Research: A Four-Decade Bibliometric Perspective

    PubMed Central

    Houlton, Jeffrey J.; Moloci, Nicholas M.; MacEachern, Mark P.; Bradford, Carol R.; Prince, Mark E.; Jagsi, Reshma

    2013-01-01

    Background. It is unknown whether changes in study sponsorship have affected the proportion of prospective research on surgery, radiotherapy, and pharmacotherapy for head and neck squamous cell carcinoma (HNSCC) being published over time. Patients and Methods. We examined prospective studies from PubMed, Ovid MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials from 1980, 1985, 1990, 1995, 2000, 2005, and 2010. Chi-squared tests were used to identify significant associations between sponsorship and authorship, treatments within study protocols, and presentation of results, whereas time-based trends were analyzed using the Cochran-Armitage test. Results. Among 309 articles, industry (70, 22.7%) and the U.S. government (65, 21%) were the most common sponsors. There was a significant increase in the proportion of industry-sponsored research (p for trend = .013) and a decline in U.S. government-sponsored research (p for trend = .001) over time. The inclusion of surgery in treatment protocols declined over the past four decades (p for trend = .003). Protocols incorporating pharmacotherapy were more likely to have industry support than those without pharmacotherapy (p = .001), whereas protocols with radiotherapy (p = .003) or surgery (p = .002) were less likely to have industry support. Conclusion. Industry is the predominant sponsor of prospective HNSCC research, with an emphasis on pharmacotherapy. PMID:23635559

  1. New approach to managing genital warts

    PubMed Central

    Lopaschuk, Catharine C.

    2013-01-01

    Abstract Objective To summarize and determine the appropriate use for the new and old management tools for genital warts. Sources of information The following databases were searched: MEDLINE, PubMed, EMBASE, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, ACP Journal Club, and Trip. The bibliographies of retrieved papers were also reviewed. Clinical trials, qualitative review articles, consensus reports, and clinical practice guidelines were retrieved. Main message Symptomatic warts are prevalent in at least 1% of the population between the ages of 15 and 49, with estimates of up to 50% of the population being infected with human papillomavirus at some point in their lifetime. Imiquimod and podophyllotoxin are 2 new treatments for external genital warts that are less painful and can be applied by patients at home. In addition, the quadrivalent human papillomavirus vaccine has been shown to be efficacious in preventing genital warts and cervical cancer. There is still a role for the older treatment methods in certain situations, such as intravaginal, urethral, anal, or recalcitrant warts; or for pregnant patients. Conclusion The new treatments of external genital warts can reduce the pain of treatment and the number of office visits. Other treatment methods are still useful in certain situations. PMID:23851535

  2. The Physiological and Biochemical Outcomes Associated with a Reflexology Treatment: A Systematic Review

    PubMed Central

    McCullough, J. E. M.; Liddle, S. D.; Sinclair, M.; Close, C.; Hughes, C. M.

    2014-01-01

    Background. Reflexology is one of the top forms of complementary and alternative medicine in the UK and is used for healthcare by a diverse range of people. However, it is offered by few healthcare providers as little scientific evidence is available explaining how it works or any health benefits it may confer. The aim of this review was to assess the current evidence available from reflexology randomised controlled trials (RCTs) that have investigated changes in physiological or biochemical outcomes. Methods. Guidelines from the Cochrane Handbook of Systematic Reviews of Interventions were followed: the following databases were searched from inception to December 2013: AMED, CAM Quest, CINAHL Plus, Cochrane Central Register of Controlled Trials, Embase, Medline Ovid, Proquest, and Pubmed. Risk of bias was assessed independently by two members of the review team and overall strength of the evidence was assessed using the Grading of Recommendations, Assessment, Development, and Evaluation guidelines. Results. Seventeen eligible RCTs met all inclusion criteria. A total of 34 objective outcome measures were analysed. Although twelve studies showed significant changes within the reflexology group, only three studies investigating blood pressure, cardiac index, and salivary amylase resulted in significant between group changes in favour of reflexology. The overall quality of the studies was low. PMID:24883067

  3. Herbal medicines for cancer cachexia: protocol for a systematic review

    PubMed Central

    Park, Bongki; Jun, Ji Hee; Jung, Jeeyoun; You, Sooseong; Lee, Myeong Soo

    2014-01-01

    Introduction To assess the efficacy of herbal medicines as a treatment of cancer cachexia. Methods and analysis We will search the following 13 electronic databases from their inception. MEDLINE (PubMed), the Cochrane Central Register of Controlled Trials (CENTRAL), EMBASE, Allied and Complementary Medicine Database (AMED), China National Knowledge Infrastructure (CNKI), Wanfang, Journal Integration Platform (VIP) and six Korean Medical Databases (KoreaMed, the Korean Traditional knowledge Portal, OASIS, DBPIA, the Research Information Service System and the Korean Studies Information Service System) without restrictions on time or language. The data will be extracted independently by two authors using predefined criteria. Disagreements will be resolved by discussion between the authors. The risk of bias will be assessed using the Cochrane risk of bias tool. Dissemination The review will be published in a journal. The review will also be disseminated electronically and in print. An update of the review will be conducted to inform and guide healthcare practice and policy. Trial registration number PROSPERO 2013:CRD42013006612. PMID:24893603

  4. The efficacy of topical and oral ivermectin in the treatment of human scabies.

    PubMed

    Panahi, Yunes; Poursaleh, Zohreh; Goldust, Mohamad

    2015-01-01

    Scabies is an itchy skin condition caused by the microscopic mite Sarcoptes scabei. The itching is caused by an allergic reaction to the mites. The treatment of choice is still controversial. It is commonly treated with topical insecticides. The aim of this study was to assess the efficacy of topical and oral ivermectin in the treatment of human scabies. We searched electronic databases (Cochrane Occupational Safety and Health Review Group Specialised Register, CENTRAL (The Cochrane Library), MEDLINE (Ovid), Pubmed, EMBASE, LILACS, CINAHL, Open Grey and WHO ICTRP) up to September 2014. Randomized controlled trials (RCTs) or cluster RCTs which compared the efficacy of ivermectin with other medications in the treatment of scabies. Interventions could be compared to each other, or to placebo or to no treatment. The author intended to extract dichotomous data (developed infection or did not develop infection) for the effects of interventions. We intended to report any adverse outcomes similarly. It has been sated that ivermectin was as effective as permethrin in the treatment of scabies. In comparison to other medications such as lindane, benzyl benzoate, crotamiton and malathion, ivermectin was more effective in the treatment of scabies. Ivermectin is an effective and cost-comparable alternative to topical agents in the treatment of scabies infection. PMID:25911032

  5. Connecting the Dots between PubMed Abstracts

    Microsoft Academic Search

    M. Shahriar Hossain; Joseph Gresock; Yvette Edmonds; Richard Helm; Malcolm Potts; Naren Ramakrishnan

    2012-01-01

    BackgroundThere are now a multitude of articles published in a diversity of journals providing information about genes, proteins, pathways, and diseases. Each article investigates subsets of a biological process, but to gain insight into the functioning of a system as a whole, we must integrate information from multiple publications. Particularly, unraveling relationships between extra-cellular inputs and downstream molecular response mechanisms

  6. Molecular Genetic Testing in Reward Deficiency Syndrome (RDS): Facts and Fiction

    PubMed Central

    Blum, Kenneth; Badgaiyan, Rajendra D.; Agan, Gozde; Fratantonio, James; Simpatico, Thomas; Febo, Marcelo; Haberstick, Brett C.; Smolen, Andrew; Gold, Mark S.

    2015-01-01

    Background The Brain Reward Cascade (BRC) is an interaction of neurotransmitters and their respective genes to control the amount of dopamine released within the brain. Any variations within this pathway, whether genetic or environmental (epigenetic), may result in addictive behaviors or RDS, which was coined to define addictive behaviors and their genetic components. Methods To carry out this review we searched a number of important databases including: Filtered: Cochrane Systematic reviews; DARE; Pubmed Central Clinical Quaries; National Guideline Clearinghouse and unfiltered resources: PsychINFO; ACP PIER; PsychSage; Pubmed/Medline. The major search terms included: dopamine agonist therapy for Addiction; dopamine agonist therapy for Reward dependence; dopamine antagonistic therapy for addiction; dopamine antagonistic therapy for reward dependence and neurogenetics of RDS. Results While there are many studies claiming a genetic association with RDS behavior, not all are scientifically accurate. Conclusion Albeit our bias, this Clinical Pearl discusses the facts and fictions behind molecular genetic testing in RDS and the significance behind the development of the Genetic Addiction Risk Score (GARSPREDX™), the first test to accurately predict one’s genetic risk for RDS.

  7. Mapping Systematic Reviews on Atopic Eczema—An Essential Resource for Dermatology Professionals and Researchers

    PubMed Central

    Futamura, Masaki; Thomas, Kim S.; Grindlay, Douglas J. C.; Doney, Elizabeth J.; Torley, Donna; Williams, Hywel C.

    2013-01-01

    Background Many research studies have been published on atopic eczema and these are often summarised in systematic reviews (SRs). Identifying SRs can be time-consuming for health professionals, and researchers. In order to facilitate the identification of important research, we have compiled an on-line resource that includes all relevant eczema reviews published since 2000. Methods SRs were searched for in MEDLINE (Ovid), EMBASE (Ovid), PubMed, the Cochrane Database of Systematic Reviews, DARE and NHS Evidence. Selected SRs were assessed against the pre-defined eligibility criteria and relevant articles were grouped by treatment category for the included interventions. All identified systematic reviews are included in the Global Resource of EczemA Trials (GREAT) database (www.greatdatabase.org.uk) and key clinical messages are summarised here. Results A total of 128 SRs reviews were identified, including three clinical guidelines. Of these, 46 (36%) were found in the Cochrane Library. No single database contained all of the SRs found. The number of SRs published per year has increased substantially over the last thirteen years, and reviews were published in a variety of clinical journals. Of the 128 SRs, 1 (1%) was on mechanism, 37 (29%) were on epidemiology, 40 (31%) were on eczema prevention, 29 (23%) were on topical treatments, 31 (24%) were on systemic treatments, and 24 (19%) were on other treatments. All SRs included searches of MEDLINE in their search methods. One hundred six SRs (83%) searched more than one electronic database. There were no language restrictions reported in the search methods of 52 of the SRs (41%). Conclusions This mapping of atopic eczema reviews is a valuable resource. It will help healthcare practitioners, guideline writers, information specialists, and researchers to quickly identify relevant up-to-date evidence in the field for improving patient care. PMID:23505516

  8. Association between suicide attempts and selective serotonin reuptake inhibitors: systematic review of randomised controlled trials

    Microsoft Academic Search

    Dean Fergusson; Steve Doucette; Kathleen Cranley Glass; Stan Shapiro; David Healy; Paul Hebert; Brian Hutton

    2005-01-01

    Objective To establish whether an association exists between use of selective serotonin reuptake inhibitors (SSRIs) and suicide attempts. Design Systematic review of randomised controlled trials. Data sources Medline and the Cochrane Collaboration's register of controlled trials (November 2004) for trials produced by the Cochrane depression, anxiety, and neurosis group. Selection of studies Studies had to be randomised controlled trials comparing

  9. Methods of hysterectomy: systematic review and meta-analysis of randomised controlled trials

    Microsoft Academic Search

    Neil Johnson; David Barlow; Anne Lethaby; Emma Tavender; Liz Curr; Ray Garry

    2005-01-01

    Objective To evaluate the most appropriate surgical method of hysterectomy (abdominal, vaginal, or laparoscopic) for women with benign disease. Design Systematic review and meta-analysis. Data sources Cochrane Menstrual Disorders and Subfertility Group Trials Register, Cochrane Central Register of Controlled Trials, Medline, Embase, and Biological Abstracts. Selection of studies Only randomised controlled trials were selected; participants had to have benign gynaecological

  10. Tacrolimus versus ciclosporin as primary immunosuppression for kidney transplant recipients: meta-analysis and meta-regression of randomised trial data

    Microsoft Academic Search

    Angela C Webster; Rebecca C Woodroffe; Rod S Taylor; Jeremy R Chapman; Jonathan C Craig

    2005-01-01

    Objective To compare the positive and negative effects of tacrolimus and ciclosporin as initial treatment for renal transplant recipients. Design Systematic review. Data sources and study selection Reports of comparative randomised trials of tacrolimus and ciclosporin identified by searches of Medline, Embase, the Cochrane Register of Controlled Trials, the Cochrane Renal Group Specialist Register, and conference proceedings. Data extraction and

  11. Staff training improved oral hygiene in patients following stroke

    Microsoft Academic Search

    Maura Edwards

    2008-01-01

    Data sourcesReports were identified using the Cochrane Stroke Group and Oral Health Group trials registers, the Cochrane CENTRAL trial register, Cochrane Library, Medline, Cinahl, Research Findings Electronic Register, National Research Register, ISI Science and Technology Proceedings, Dissertation Abstracts and Conference Papers Index, and the reference lists from relevant papers. Authors and researchers in the field were also contacted.Study selectionRandomised controlled

  12. The risk factors for elevated blood pressure and how to address cardiovascular risk factors: a review in paediatric populations

    Microsoft Academic Search

    K D Monyeki; H C G Kemper

    2008-01-01

    This paper examines the epidemiology of hypertension and management strategies of cardiovascular diseases (CVDs) in paediatric populations in sub-Saharan Africa and other parts of the world in the 21st century. A computerized literature search was carried out using Medline, Evidence-Based Child Health (A Cochrane Review Journal), the Cochrane Library and Cochrane Child Health Field. A manual search in the African

  13. Use of autologous fat grafting for reconstruction postmastectomy and breast conserving surgery: a systematic review protocol

    PubMed Central

    Agha, Riaz A; Goodacre, Tim; Orgill, Dennis P

    2013-01-01

    Introduction There is growing interest in the potential use of autologous fat grafting (AFG) for the purposes of breast reconstruction. However, concerns have been raised regarding the technique's clinical effectiveness, safety and interference with screening mammography. The objective of this systematic review was to determine the oncological, clinical, aesthetic and functional, patient reported, process and radiological outcomes for AFG. Methods and analysis All original studies, including randomised controlled trials, cohorts studies, case–control studies, case series and case reports involving women undergoing breast reconstruction. All AFG techniques performed for the purposes of reconstruction in the postmastectomy or breast conserving surgery setting will be considered. Outcomes are defined within this protocol along; oncological, clinical, aesthetic and functional, patient reported, process and radiological domains. The search strategy has been devised to find papers about ‘fat grafting and breast reconstruction’ and is outlined within the body of this protocol. The full search strategy is outlined within the body of the protocol. The following electronic databases will be searched from 1 January 1986 to 6 June 2013: PubMed, MEDLINE, EMBASE, SCOPUS, CINAHL, PsycINFO, SciELO, The Cochrane Library, including the Cochrane Database of Systematic Reviews (CDSR), Cochrane Central Register of Controlled Trials (CENTRAL), Database of Abstracts of Reviews of Effect (DARE), the Cochrane Methodology Register, Health Technology Assessment Database, the NHS Economic Evaluation Databases and Cochrane Groups, ClinicalTrials.gov, Current Controlled Trials Database, the World Health Organisation (WHO) International Clinical Trials Registry Platform, UpToDate.com, NHS Evidence and the York Centre for Reviews and Dissemination. Grey literature searches will also be conducted as detailed in our review protocol. Eligibility assessment occurred in two stages, title and abstract screening and then full text assessment. Data were extracted and stored in a database with standardised extraction fields to facilitate easy and consistent data entry. Ethics and dissemination This systematic review will be published in a peer-reviewed journal. It will also be presented at national and international conferences in the fields of plastic, reconstructive and aesthetic surgery and at more general surgical and methodological conferences. It will be disseminated electronically and in print. Brief reports of the review findings will be disseminated directly to the appropriate audiences of surgeons and societies through email and other modes of communication. Updates of the review will be conducted to inform and guide healthcare practice and policy. Protocol Registration PROSPERO—National Institute of Health Research (NIHR) Prospective Register of Systematic Reviews (CRD42013005254) PMID:24154518

  14. Review of the Complications Associated with Treatment of Oropharyngeal Cancer: A Guide to the Dental Practitioner

    PubMed Central

    Turner, Lena; Mupparapu, Muralidhar; Akintoye, Sunday O

    2013-01-01

    Objectives Oropharyngeal cancer (OPC) is the 6th most common cancer worldwide. Focus on risk factors, improved diagnostic methods and effective management strategies have made it possible to successfully treat OPC. However, the 5-year survival rate has not improved for several years due to multiple treatment complications, tissue morbidity, loss of function and diminished quality of life. Survivors are faced with complications like oral mucositis, hyposalivation, osteoradionecrosis; tissue fibrosis, morbidity from jaw resection; disfigurement and loss of function that further diminish quality of life. The aim of this review is to highlight major complications associated with treatment of OPC via a literature search and review of available options for identification and management of these complications. Data Sources Relevant publications on oral complications of OPC therapy were thoroughly reviewed from the literature published between the years 1988 and 2012. Material and Method We evaluated reported incidence, prevalence and risk factors for oral complications of chemotherapy and radiotherapy for OPC. The authors conducted electronic search using English language databases namely PubMed Plus, Medline (Pre-Medline and Medline), Cochrane Database of systematic reviews (evidence-based medicine), Dentistry & Oral sciences source, AccessScience, Embase, Evidence-Based Medicine Reviews Multifile, Google Scholar, ISI Journal Citation Reports, Ovid Multi-Database. Conclusion We identified the most common complications associated with the treatment of oral cancers. Based on the information gathered, there is evidence that survival of OPC extends beyond eradication of the diseased tissue. Understanding the potential treatment complications and utilizing available resources to prevent and minimize them are important. Caring for OPC survivors should be a multidisciplinary team approach involving the dentist, oncologist, internist and social worker to improve the currently stagnant 5-year survival rate of OPC. More emphasis on improved quality of life after elimination of the cancer will ultimately improve OPC survivorship. PMID:23444208

  15. Circumcision - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian (???????) Somali (af Soomaali) Spanish (español) ... ?????? - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Male Circumcision ???? - ??? (Korean) Bilingual PDF ...

  16. Swallowing Disorders - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian (???????) Somali (af Soomaali) Spanish (español) ... ???? - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Barium Swallow ?? ???? - ??? (Korean) Bilingual ...

  17. Ultrasound - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian (???????) Somali (af Soomaali) Spanish (español) ... ????? - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Echocardiogram ?????? - ??? (Korean) Bilingual PDF Health ...

  18. Cesarean Section - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Chinese - Traditional (????) Hindi (??????) Japanese (???) Korean (???) Portuguese (português) Somali (af Soomaali) Spanish (español) ... ???????? - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Your Recovery after Cesarean Birth ???? ?? ...

  19. Breast Cancer - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... français) Hindi (??????) Japanese (???) Khmer (Khmer) Korean (???) Portuguese (português) Russian (???????) Somali (af Soomaali) ... Health Khmer (Khmer) Bilingual PDF Harborview Medical Center Korean (???) Breast Biopsy ?? ?? - ??? (Korean) Bilingual ...

  20. COPD - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Portuguese (português) Russian (???????) Somali (af Soomaali) ... COPD) - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Chronic Obstructive Pulmonary Disease (COPD) ????? ??? - ...

  1. Meningitis - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... français) Haitian Creole (Kreyol) Hmong (Hmoob) Japanese (???) Korean (???) Romanian (Român?) Russian (???????) Samoan (Gagana Samoa) ... ???? - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Lumbar Puncture ?? ?? - ??? (Korean) Bilingual ...

  2. Prenatal Care - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Portuguese (português) Russian (???????) Somali (af Soomaali) ... ???? - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Fetal Movement Count ??? ??? ?? - ??? ( ...

  3. Colorectal Cancer - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Portuguese (português) Russian (???????) Somali (af Soomaali) ... ???? - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Cancer of the Colon and Rectum ??? ...

  4. Fractures - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian (???????) Somali (af Soomaali) Spanish (español) ... ?????????? - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Bone Fractures ?? - ??? (Korean) Bilingual PDF ...

  5. Bone Cancer - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian (???????) Somali (af Soomaali) Spanish (español) ... ????? - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Bone Scan ? (?) ?? - ??? (Korean) ...

  6. Hepatitis B - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????) Chinese - Traditional (????) Hmong (Hmoob) Khmer (Khmer) Korean (???) Laotian (Lao) Spanish (español) Tagalog (Tagalog) Turkish ( ... Health Khmer (Khmer) Bilingual PDF Harborview Medical Center Korean (???) Hepatitis B and Moms-to-be English ...

  7. Flu - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ??????) Hmong (Hmoob) Japanese (???) Khmer (Khmer) Korean (???) Laotian (Lao) Polish (polski) Portuguese (português) Punjabi ( ... Khmer) PDF Public Health - Seattle and King County Korean (???) Home Care for Pandemic Flu ??? ??? ...

  8. Breast Diseases - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian (???????) Somali (af Soomaali) Spanish (español) ... ???? - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Breast Biopsy ?? ?? - ??? (Korean) Bilingual ...

  9. Lung Diseases - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian (???????) Somali (af Soomaali) Spanish (español) ... ?????? - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Bronchoscopy ???? ?? - ??? (Korean) Bilingual PDF ...

  10. Hypoglycemia - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Portuguese (português) Russian (???????) Somali (af Soomaali) ... ??? - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Fasting Blood Sugar Test ?? ?? ?? - ...

  11. Child Safety - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Marshallese (kajin Majöl) Portuguese (português) Russian (???????) ... ????????????????????????? - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Child Safety Checklist ??? ?? ??? - ??? ( ...

  12. Back Pain - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????) Chinese - Traditional (????) French (français) Japanese (???) Korean (???) Russian (???????) Somali (af Soomaali) Spanish (español) ... ???????? - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Exercises for Your Back ???? - ??? (Korean) ...

  13. Concussion - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... enable JavaScript. Arabic (???????) French (français) Japanese (???) Korean (???) Russian (???????) Somali (af Soomaali) Spanish (español) ... ??????? - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Types of Brain Injury ???? ?? - ??? ( ...

  14. Childbirth - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Portuguese (português) Russian (???????) Somali (af Soomaali) ... ???????) - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Signs of Labor ?? ?? - ??? (Korean) ...

  15. Breathing Problems - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... JavaScript. French (français) Hindi (??????) Japanese (???) Korean (???) Russian (???????) Somali (af Soomaali) Spanish (español) ... ???????? - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Incentive Spirometer ??? ???? - ??? (Korean) Bilingual ...

  16. Cataract - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Portuguese (português) Russian (???????) Somali (af Soomaali) ... ??? - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Cataract ??? - ??? (Korean) Bilingual PDF Health ...

  17. Bone Diseases - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian (???????) Somali (af Soomaali) Spanish (español) ... ????? - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Bone Scan ? (?) ?? - ??? (Korean) ...

  18. Kidney Diseases - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian (???????) Somali (af Soomaali) Spanish (español) ... IVP) - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) 24-Hour Urine Test 24-?? ???? - ...

  19. Mobility Aids - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian (???????) Somali (af Soomaali) Spanish (español) ... ??????????????? - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Crutch Walking ?? ?? - ??? (Korean) Bilingual ...

  20. Angina - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Portuguese (português) Russian (???????) Somali (af Soomaali) ... ??? - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Angina ??? - ??? (Korean) Bilingual PDF Health ...

  1. Cholesterol - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Portuguese (português) Russian (???????) Somali (af Soomaali) ... ??????? - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Cholesterol ????? - ??? (Korean) Bilingual PDF Health ...

  2. Prenatal Testing - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Portuguese (português) Russian (???????) Somali (af Soomaali) ... ???????? - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) AFP (Alpha-Fetoprotein) Test ?? ?? ???) ...

  3. Patient Safety - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian (???????) Somali (af Soomaali) Spanish (español) ... ???????????? - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Appointment Reminder ?? ?? - ??? (Korean) Bilingual ...

  4. Bladder Diseases - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian (???????) Somali (af Soomaali) Spanish (español) ... IVP) - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Care of a Foley Catheter ?? ??? ...

  5. Arthritis - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian (???????) Somali (af Soomaali) Spanish (español) ... ??? - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Arthritis ??? - ??? (Korean) Bilingual PDF Health ...

  6. Nuclear Scans - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian (???????) Somali (af Soomaali) Spanish (español) ... ????????? - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Bone Scan ? (?) ?? - ??? (Korean) ...

  7. Sleep Disorders - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Portuguese (português) Russian (???????) Somali (af Soomaali) ... ????????? - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Common Sleep Problems ???? ?? ?? - ??? ( ...

  8. Breastfeeding - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... français) Hindi (??????) Hmong (Hmoob) Japanese (???) Korean (???) Marshallese (kajin Majöl) Portuguese (português) Russian (???????) ... Milk ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Getting Started Breastfeeding Your Baby ???? ? ...

  9. Acute Bronchitis - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian (???????) Somali (af Soomaali) Spanish (español) ... ???? - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Bronchitis ???? - ??? (Korean) Bilingual PDF Health ...

  10. Cervical Cancer - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... français) Hindi (??????) Japanese (???) Khmer (Khmer) Korean (???) Russian (???????) Somali (af Soomaali) Spanish (español) ... Life Khmer (Khmer) Bilingual PDF Harborview Medical Center Korean (???) Colposcopy ???? ?? - ??? (Korean) Bilingual PDF ...

  11. Laboratory Tests - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... français) Hindi (??????) Japanese (???) Khmer (Khmer) Korean (???) Oromo (Afaan Oromo) Russian (???????) Somali (af ... Collection Khmer (Khmer) Bilingual PDF Harborview Medical Center Korean (???) 24-Hour Urine Test 24-?? ???? - ...

  12. Gallbladder Diseases - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Portuguese (português) Russian (???????) Somali (af Soomaali) ... ????? - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) ERCP (Endoscopic Retrograde Cholangiopancreatography) ??? ??????? ??? ...

  13. Burns - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian (???????) Somali (af Soomaali) Spanish (español) ... ????? - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Burn Care ?? ?? - ??? (Korean) Bilingual ...

  14. Anal Disorders - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ???????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian (???????) Somali (af Soomaali) Spanish (español) ... ?????? - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Barium Enema ?? ???? - ??? (Korean) Bilingual ...

  15. Angioplasty - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian (???????) Somali (af Soomaali) Spanish (español) ... ?????????????????? - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Heart Cath and Heart Angioplasty ?? ???? ...

  16. Alzheimer's Disease - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Deutsch) Hindi (??????) Italian (italiano) Japanese (???) Korean (???) Polish (polski) Portuguese (português) Russian (???????) Somali ( ... Interactive Tour English ???????? - ??? (Japanese) Alzheimer's Association Korean (???) Alzheimer's Disease ?????? - ??? (Korean) Bilingual PDF ...

  17. Surgery - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Portuguese (português) Russian (???????) Somali (af Soomaali) ... ???????? - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Getting Your Skin Ready for Surgery ?? ...

  18. Atrial Fibrillation - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Portuguese (português) Russian (???????) Somali (af Soomaali) ... ???? - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Atrial Fibrillation ???? - ??? (Korean) Bilingual PDF ...

  19. Allergy - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian (???????) Somali (af Soomaali) Spanish (español) ... ????? - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Allergies ???? - ??? (Korean) Bilingual PDF Health ...

  20. Cancer - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... français) Hindi (??????) Japanese (???) Khmer (Khmer) Korean (???) Portuguese (português) Russian (???????) Somali (af Soomaali) ... Prevention Khmer (Khmer) Bilingual PDF Harborview Medical Center Korean (???) Cancer ? - ??? (Korean) Bilingual PDF Health ...

  1. Anemia - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian (???????) Somali (af Soomaali) Spanish (español) ... ??? - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Anemia ?? - ??? (Korean) Bilingual PDF Health ...

  2. Colonoscopy - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian (???????) Somali (af Soomaali) Spanish (español) ... S?????? - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Colonoscopy with Bowel Prep: Go-Lytely, Colyte, ...

  3. Cancer Chemotherapy - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Portuguese (português) Russian (???????) Somali (af Soomaali) ... ???????????? - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Chemotherapy ???? - ??? (Korean) Bilingual PDF Health ...

  4. Diabetes - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ??????) Hmong (Hmoob) Japanese (???) Khmer (Khmer) Korean (???) Laotian (Lao) Oromo (Afaan Oromo) Portuguese (português) ... English Khmer (Khmer) PDF National Diabetes Education Program Korean (???) 4 Steps to Control Your Diabetes for ...

  5. Vaginal Diseases - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Portuguese (português) Russian (???????) Somali (af Soomaali) ... ???? - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Colposcopy ???? ?? - ??? (Korean) Bilingual PDF ...

  6. Pneumonia - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Kreyol) Hindi (??????) Hmong (Hmoob) Japanese (???) Korean (???) Romanian (Român?) Russian (???????) Samoan (Gagana Samoa) ... ???? - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Pneumococcal Conjugate Vaccine English ??? (Korean) PDF ...

  7. Appendicitis - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Portuguese (português) Russian (???????) Somali (af Soomaali) ... Child ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Appendectomy ?? ??? - ??? (Korean) Bilingual PDF ...

  8. Heart Diseases - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian (???????) Somali (af Soomaali) Spanish (español) ... TEE) - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Angiogram ?? ?? ?? - ??? (Korean) Bilingual ...

  9. Arrhythmia - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian (???????) Somali (af Soomaali) Spanish (español) ... ???????? - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Electrocardiogram (ECG or EKG) ??? (ECG ?? ...

  10. Sleep Apnea - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Portuguese (português) Russian (???????) Somali (af Soomaali) ... ???? - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) CPAP (Continuous Positive Airway Pressure) CPAP (??? ...

  11. Vascular Diseases - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian (???????) Somali (af Soomaali) Spanish (español) ... ???? - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Angiogram ?? ?? ?? - ??? (Korean) Bilingual ...

  12. Animal Bites - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Portuguese (português) Russian (???????) Somali (af Soomaali) ... ?????????? - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Animal Bites and Scratches ???? ???? ??? ...

  13. Diabetes Medicines - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian (???????) Somali (af Soomaali) Spanish (español) ... 2???????????? - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Drawing up One Insulin ??? ?? - ??? ( ...

  14. Childhood Immunization - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Hmong (Hmoob) Ilocano (ilokano) Japanese (???) Khmer (Khmer) Korean (???) Laotian (Lao) Polish (polski) Portuguese (português) Punjabi ( ... Action Coalition; Centers for Disease Control and Prevention Korean (???) Vaccines for Your Children ??????? - ??? (Korean) ...

  15. Acne - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... please enable JavaScript. Arabic (???????) Chinese - Traditional (????) Korean (???) Spanish (español) Vietnamese (Tiê?ng Viê?t) Arabic (???????) ... Institute of Arthritis and Musculoskeletal and Skin Diseases Korean (???) What Is Acne? English ????? ????? - ??? ( ...

  16. Dementia - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian (???????) Somali (af Soomaali) Spanish (español) ... ?????? - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Legal Plans: Assisting the Person with Dementia ...

  17. Brain Diseases - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... page, please enable JavaScript. French (français) Japanese (???) Korean (???) Russian (???????) Somali (af Soomaali) Spanish (español) ... ??????? - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Brain Scan ? ?? - ??? (Korean) Bilingual ...

  18. Medicines - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian (???????) Somali (af Soomaali) Spanish (español) ... ??????? - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Giving Medicine by Subcutaneous Injection ?? ??? ...

  19. Constipation - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian (???????) Somali (af Soomaali) Spanish (español) ... ?? - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Constipation ?? - ??? (Korean) Bilingual PDF Health ...

  20. Asthma - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Portuguese (português) Russian (???????) Somali (af Soomaali) ... ???? - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Asthma ?? - ??? (Korean) Bilingual PDF Health ...

  1. Neurologic Diseases - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian (???????) Somali (af Soomaali) Spanish (español) ... ???? - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) EEG ?? ?? - ??? (Korean) Bilingual PDF ...

  2. Back Injuries - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????) Chinese - Traditional (????) French (français) Japanese (???) Korean (???) Russian (???????) Somali (af Soomaali) Spanish (español) ... ???????? - ??? (Japanese) Bilingual PDF Health Information Translations Korean (???) Back Health and Safety ?? ??? ?? - ...

  3. Aortic Aneurysm - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Are Here: Home ? Multiple Languages ? All Health Topics ? Aortic Aneurysm URL of this page: http://www.nlm.nih. ... V W XYZ List of All Topics All Aortic Aneurysm - Multiple Languages To use the sharing features on ...

  4. Liver Cancer - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Chinese - Traditional (????) Hmong (Hmoob) Korean (???) Laotian (Lao) Spanish (español) Tagalog (Tagalog) Vietnamese (Tiê?ng Viê?t) Burmese ( ... Korean) PDF Stanford University, Asian Liver Center Laotian (Lao) Know HBV: What Every Asian and Pacific Islander ...

  5. Dialysis - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... page, please enable JavaScript. Arabic (???????) Russian (???????) Somali (af Soomaali) Spanish (español) Arabic (???????) Dialysis (Arabic) ... ?????? - ??????? (Russian) Bilingual PDF Health Information Translations Somali (af Soomaali) Dialysis Kaadi-saarista - af Soomaali (Somali) ...

  6. Dietary Sodium - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... page, please enable JavaScript. Arabic (???????) Khmer (Khmer) Somali (af Soomaali) Spanish (español) Arabic (???????) Lowering Sodium ... Sodium Khmer (Khmer) Bilingual PDF Harborview Medical Center Somali (af Soomaali) Lowering Sodium in Your Diet Yareenta ...

  7. Blood - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... sharing features on this page, please enable JavaScript. Somali (af Soomaali) Spanish (español) Somali (af Soomaali) What is Blood? Muxuu yahay dhiig? - af Soomaali (Somali) Bilingual Harborview Medical Center White blood cells (WBC) ...

  8. Diabetic Foot - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Arabic (???????) Chinese - Simplified (????) Chinese - Traditional (????) Somali (af Soomaali) Spanish (español) Tigrinya (tigrinya) Amharic (amarunya) ... Chinese - Traditional) PDF Chinese Community Health Resource Center Somali (af Soomaali) Daily Foot Check SONKOROWGA/MACAANKA: XANAANADA ...

  9. Tooth Disorders - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Are Here: Home ? Multiple Languages ? All Health Topics ? Tooth Disorders URL of this page: http://www.nlm.nih. ... V W XYZ List of All Topics All Tooth Disorders - Multiple Languages To use the sharing features on ...

  10. Coronavirus Infections - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Are Here: Home ? Multiple Languages ? All Health Topics ? Coronavirus Infections URL of this page: http://www.nlm.nih. ... V W XYZ List of All Topics All Coronavirus Infections - Multiple Languages To use the sharing features on ...

  11. Urinary Incontinence - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Spanish (español) Arabic (???????) Care of a Foley Catheter (Arabic) ??????? Bilingual PDF Health Information Translations Transvaginal Tape English (Arabic) ?????? ??????? - ??????? Multimedia Patient Education Institute Urinary Incontinence in Women (Arabic) ??? ????? ...

  12. After Surgery - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Viê?t) Home Care Instructions After Surgery H??ng D?n Ch?m Sóc T?i Nhà sau khi Ph?u Thu?t - Tiê?ng ... Health Information Translations Your Hospital Care After Surgery Ch?m Sóc ? B?nh Vi?n sau khi Ph?u Thu?t - ...

  13. Healthlines | NIH MedlinePlus the Magazine

    MedlinePLUS

    ... nih.gov/publications/Medicine/medicine.htm . White House "Precision Medicine Initiative" Details Released Earlier this year, President Obama announced a $215 million Precision Medicine Initiative. Instead of "one size fits all" health ...

  14. Tutorials for Africa - Malaria: MedlinePlus

    MedlinePLUS

    Tutorials for Africa: Malaria In Uganda, the burden of malaria outranks that of all other diseases. This tutorial includes information about ... project is a collaboration between the U.S. National Library of Medicine and Makerere University Faculty of Medicine ...

  15. Tutorials for Africa - Diarrhea: MedlinePlus

    MedlinePLUS

    Tutorials for Africa: Diarrhea Diarrhea remains one of the leading causes of childhood morbidity and mortality in the developing world. This ... project is a collaboration between the U.S. National Library of Medicine and Makerere University Faculty of Medicine ...

  16. Tutorials for Africa: MedlinePlus

    MedlinePLUS

    ... nih.gov/medlineplus/africa/index.html Tutorials for Africa To use the sharing features on this page, please enable JavaScript. The National Library of Medicine (NLM) in collaboration with the Faculty ...

  17. Rheumatoid Arthritis - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Are Here: Home ? Multiple Languages ? All Health Topics ? Rheumatoid Arthritis URL of this page: http://www.nlm.nih. ... V W XYZ List of All Topics All Rheumatoid Arthritis - Multiple Languages To use the sharing features on ...

  18. Herbal Medicine - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Are Here: Home ? Multiple Languages ? All Health Topics ? Herbal Medicine URL of this page: http://www.nlm.nih. ... V W XYZ List of All Topics All Herbal Medicine - Multiple Languages To use the sharing features on ...

  19. Head Lice - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Are Here: Home ? Multiple Languages ? All Health Topics ? Head Lice URL of this page: http://www.nlm.nih. ... V W XYZ List of All Topics All Head Lice - Multiple Languages To use the sharing features on ...

  20. Pain - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Your Pain (Arabic) ??????? Bilingual PDF Health Information Translations Expressing Your Pain English (Arabic) ?????? ?? ????? - ... Vašem bolu - Bosanski (Bosnian) Bilingual PDF Health Information Translations Chinese - Simplified (????) About Your Pain ?????? - ???? ( ...

  1. Gallstones - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????? ??????? ??????? - ??????? Bilingual PDF Health Information Translations Gallstones English (Arabic) ??????? ????????? - ??????? Multimedia Patient ... ?????? - ???? (Chinese - Simplified) Bilingual PDF Health Information Translations Gallstones English ??? - ???? (Chinese - Simplified) PDF Chinese ...

  2. Knee Replacement - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Knee Replacement (Arabic) ??????? Bilingual PDF Health Information Translations Bosnian (Bosanski) Total Knee Replacement Potpuna zamjena koljena - Bosanski (Bosnian) Bilingual PDF Health Information Translations Chinese - Simplified (????) Total Knee Replacement ?????? - ???? ( ...

  3. Glaucoma - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Glaucoma (Arabic) ????????? - ??????? Bilingual PDF Health Information Translations Chinese - Simplified (????) Glaucoma English ??? - ???? (Chinese - ... ??? - ???? (Chinese - Simplified) Bilingual PDF Health Information Translations Chinese - Traditional (????) Glaucoma English ??? - ???? (Chinese - ...

  4. Hepatitis - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ?????? ????? ???????? - ??????? Bilingual PDF Health Information Translations Chinese - Simplified (????) Viral Hepatitis ????? - ???? (Chinese - Simplified) Bilingual PDF Health Information Translations Chinese - Traditional (????) Viral Hepatitis ????? - ???? (Chinese - ...

  5. Kidney Failure - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Arabic) ????? ?????? - ??????? Bilingual PDF Health Information Translations Kidney Failure English (Arabic) ????? ?????? - ??????? Multimedia ... rada bubrega - Bosanski (Bosnian) Bilingual PDF Health Information Translations Chinese - Simplified (????) Kidney Failure ?? - ???? (Chinese - ...

  6. MRI Scans - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Resonance Imaging) (Arabic) ??????? Bilingual PDF Health Information Translations Chinese - Simplified (????) MRI (Magnetic Resonance Imaging) ??????(MRI) - ???? (Chinese - Simplified) Bilingual PDF Health Information Translations Chinese - Traditional (????) MRI (Magnetic Resonance Imaging) ??????( ...

  7. Newborn Screening - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ?????? ????? ????? - ??????? Bilingual PDF Health Information Translations Newborn Screening English (Arabic) ??? ????? ??????? - ??????? ... vaše bebe - Bosanski (Bosnian) Bilingual PDF Health Information Translations Chinese - Simplified (????) Hearing Test for Your Baby ...

  8. Menopause - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????? (?? ????? - ??????? Bilingual PDF Health Information Translations Menopause English (Arabic) ?? ????? - ??????? Multimedia Patient ... ??????? - ???? (Chinese - Simplified) Bilingual PDF Health Information Translations Menopause English ????? - ???? (Chinese - Simplified) PDF Chinese ...

  9. Mammography - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ??? ????? ??????? - ??????? Bilingual PDF Health Information Translations Mammography English (Arabic) ????? ??????? ???????? - ??????? Multimedia ... ??X??? - ???? (Chinese - Simplified) Bilingual PDF Health Information Translations Chinese - Traditional (????) Mammogram ?????? - ???? (Chinese - Traditional) ...

  10. Depression - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Feeling Sad (Arabic) ??????? Bilingual PDF Health Information Translations Bosnian (Bosanski) Feeling Sad Osje?anje tuge - Bosanski (Bosnian) Bilingual PDF Health Information Translations Chinese - Simplified (????) Depression English ??? - ???? (Chinese - ...

  11. Joint Disorders - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ?????????? ?????? ??????? - ??????? Bilingual PDF Health Information Translations Bosnian (Bosanski) Home Care After Total Joint Replacement ... zamjene zgloba - Bosanski (Bosnian) Bilingual PDF Health Information Translations Chinese - Simplified (????) Home Care After Total Joint ...

  12. Drug Abuse - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... or Dependence (Arabic) ??????? Bilingual PDF Health Information Translations Bosnian (Bosanski) Substance Abuse or Dependence Zloupotreba opojnih ... ili ovisnost - Bosanski (Bosnian) Bilingual PDF Health Information Translations Chinese - Simplified (????) Substance Abuse or Dependence ??????? - ...

  13. Heart Failure - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Arabic) ???? ????? - ??????? Bilingual PDF Health Information Translations Bosnian (Bosanski) Heart Failure Zatajenje srca - Bosanski (Bosnian) Bilingual PDF Health Information Translations Chinese - Simplified (????) Heart Failure ???? - ???? (Chinese - ...

  14. Hysterectomy - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Arabic) ??????? ????? - ??????? Bilingual PDF Health Information Translations Chinese - Simplified (????) Hysterectomy ????? - ???? (Chinese - Simplified) Bilingual PDF Health Information Translations Chinese - Traditional (????) Hysterectomy ????? - ???? (Chinese - Traditional) ...

  15. Lung Cancer - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Arabic) ????? ????? - ??????? Bilingual PDF Health Information Translations Bosnian (Bosanski) Lung Cancer Karcinom plu?a - Bosanski (Bosnian) Bilingual PDF Health Information Translations Chinese - Simplified (????) Lung Cancer ?? - ???? (Chinese - ...

  16. Heart Attack - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Arabic) ?????? ??????? - ??????? Bilingual PDF Health Information Translations Heart Attack English (Arabic) ?????? ??????? - ??????? Multimedia ... Sr?ani udar - Bosanski (Bosnian) Bilingual PDF Health Information Translations Chinese - Simplified (????) Heart Attack ????? - ???? (Chinese - ...

  17. Headache - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ???????) Headaches (Arabic) ??????? Bilingual PDF Health Information Translations Chinese - Simplified (????) Headaches ?? - ???? (Chinese - Simplified) Bilingual PDF Health Information Translations Chinese - Traditional (????) Headaches ?? - ???? (Chinese - Traditional) ...

  18. Fever - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... a Temperature (Arabic) ??????? Bilingual PDF Health Information Translations Bosnian (Bosanski) Taking a Temperature Mjerenje temperature - Bosanski (Bosnian) Bilingual PDF Health Information Translations Chinese - Simplified (????) Taking a Temperature ??? - ???? ( ...

  19. Oil Spills - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Are Here: Home ? Multiple Languages ? All Health Topics ? Oil Spills URL of this page: http://www.nlm.nih. ... V W XYZ List of All Topics All Oil Spills - Multiple Languages To use the sharing features on ...

  20. MedlinePlus Connect: Web Service

    MedlinePLUS

    ... function. For a response in XML, use: knowledgeResponseType=text/xml or leave the knowledgeResponseType parameter out of ... terms. summary class= "NLMattribution" Attribution acknowledgement for summary text, if the majority of the summary was from ...

  1. Drugs, Herbs and Supplements: MedlinePlus

    MedlinePLUS

    ... http://www.nlm.nih.gov/medlineplus/druginformation.html Drugs, Herbs and Supplements To use the sharing features on this page, please enable JavaScript. Drugs Learn about your prescription drugs and over-the- ...

  2. Kidney Cancer - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Are Here: Home ? Multiple Languages ? All Health Topics ? Kidney Cancer URL of this page: http://www.nlm.nih. ... V W XYZ List of All Topics All Kidney Cancer - Multiple Languages To use the sharing features on ...

  3. Oncofertility | NIH MedlinePlus the Magazine

    MedlinePLUS

    ... approached my decision to have children with my husband just three years ago, I carried with me ... To complicate the picture, the insurance that my husband and I had did not cover the treatments ...

  4. Quitting Smoking - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Viê?t (Vietnamese) Bilingual PDF Harborview Medical Center Quitting Smoking Can Help You Recover from Cancer CAI NGHI?N THU?C LÁ CÓ TH? GIÚP B?N KH?I B?NH UNG TH? - Tiê?ng Viê?t (Vietnamese) Bilingual ...

  5. Healthlines | NIH MedlinePlus the Magazine

    MedlinePLUS

    ... families with children 2 to 5 years old. Lessons use art, storytelling, music, and dance to teach ... can teach parents, caregivers, and children using the lessons. EatPlayGrow was developed through a partnership between the ...

  6. Chemical Emergencies - Multiple Languages: MedlinePlus

    MedlinePLUS

    GO Chemical Emergencies - Multiple Languages To use the sharing features on this page, please enable JavaScript. Amharic (amarunya) Arabic (???????) ... Amharic) PDF Minnesota Department of Health Arabic (???????) Chemical Emergencies (Arabic) ????? ??????? ?????????? - ??????? Bilingual PDF Health ...

  7. Text mining: Generating hypotheses from MEDLINE

    Microsoft Academic Search

    Padmini Srinivasan

    2004-01-01

    Hypothesis generation, a crucial initial step for making scientific discoveries, relies on prior knowledge, experi- ence, and intuition. Chance connections made between seemingly distinct subareas sometimes turn out to be fruitful. The goal in text mining is to assist in this process by automatically discovering a small set of interesting hypotheses from a suitable text collection. In this report, we

  8. Title | NIH MedlinePlus the Magazine

    MedlinePLUS

    ... please turn JavaScript on. Medical Movies on the Web Debuts with Gene Kelly's "Combat Fatique Irritability" 1945 ... of Medicine To view Medical Movies on the Web, go to: www.nlm.nih.gov/hmd/collections/ ...

  9. Health Information in Korean (???): MedlinePlus

    MedlinePLUS

    ... ??? (Korean) Bilingual PDF Health Information Translations Motor Vehicle Safety Safety with Car Seats and Booster Seats ... Korean) Bilingual PDF Health Information Translations Traumatic Brain Injury Brain Scan ? ?? - ??? (Korean) Bilingual PDF ...

  10. Health Information in Ukrainian (??????????): MedlinePlus

    MedlinePLUS

    ... ?????????? (Ukrainian) Bilingual PDF Health Information Translations Motor Vehicle Safety Safety with Car Seats and Booster Seats ... Ukrainian) Bilingual PDF Health Information Translations Traumatic Brain Injury Brain Scan ??????????????????? - ?????????? (Ukrainian) Bilingual PDF Health ...

  11. Health Information in Arabic (???????): MedlinePlus

    MedlinePLUS

    ... Arabic) ??????? Bilingual PDF Health Information Translations Motor Vehicle Safety Safety with Car Seats and Booster Seats ( ... ???????????? - ??????? Multimedia Patient Education Institute N Neck Injuries and Disorders Neck Exercises - English (Arabic) ?????? ?????? - ...

  12. Health Information in Japanese (???): MedlinePlus

    MedlinePLUS

    ... ??? (Japanese) Bilingual PDF Health Information Translations Motor Vehicle Safety Safety with Car Seats and Booster Seats ... Japanese) Bilingual PDF Health Information Translations Traumatic Brain Injury Brain Scan ??????? - ??? (Japanese) Bilingual PDF Health ...

  13. Health Information in Hindi (??????): MedlinePlus

    MedlinePLUS

    ... ???? (Hindi) Bilingual PDF Health Information Translations Motor Vehicle Safety Safety with Car Seats and Booster Seats ... Hindi) Bilingual PDF Health Information Translations Wounds and Injuries Incision Care: No Dressing ?????? (Hindi) Bilingual ...

  14. NIH MedlinePlus Advisory Group

    MedlinePLUS

    ... Cravedi, Ex-Officio Director, Office of Communications and Public Liaison National Library of Medicine Stephanie Dennis, Ex-Officio Head, Health ... Office of Dietary Supplements Martha Fishel, Chair Chief, Public Services ... Library of Medicine Lakshmi Grama Senior Digital Content Strategist ...

  15. Healthlines | NIH MedlinePlus the Magazine

    MedlinePLUS

    ... of tips. For example, a diet rich in fruits and vegetables, particularly dark leafy vegetables, such as spinach, kale, or collard greens, can help to keep your eyes healthy and disease free. There's also information on finding an eye ...

  16. Dietary Fats - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Are Here: Home ? Multiple Languages ? All Health Topics ? Dietary Fats URL of this page: http://www.nlm.nih. ... V W XYZ List of All Topics All Dietary Fats - Multiple Languages To use the sharing features on ...

  17. Health Information in Russian (???????): MedlinePlus

    MedlinePLUS

    ... ??????? (Russian) Bilingual PDF Health Information Translations Tooth Disorders Toothache ?????? ???? - ??????? (Russian) Bilingual PDF Health Information Translations Traumatic Brain Injury Brain Scan ???????????????????? - ??????? (Russian) Bilingual ...

  18. Endoscopy - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... sharing features on this page, please enable JavaScript. Arabic (???????) French (français) Japanese (???) Korean (???) Russian (???????) Somali (af Soomaali) Spanish (español) Ukrainian (??????????) Arabic (???????) Diagnostic Laparoscopy English (Arabic) ????? ????? ???????? - ...

  19. Parkinson's Disease - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... sharing features on this page, please enable JavaScript. Arabic (???????) Chinese - Simplified (????) Chinese - Traditional (????) French ( ... ???) Russian (???????) Somali (af Soomaali) Spanish (español) Arabic (???????) Parkinson's Disease English (Arabic) ??? ???????? - ??????? ...

  20. Prostate Cancer - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... sharing features on this page, please enable JavaScript. Arabic (???????) Chinese - Simplified (????) Chinese - Traditional (????) French ( ... Soomaali) Spanish (español) Ukrainian (??????????) Vietnamese (Tiê?ng Viê?t) Arabic (???????) Prostate Cancer English (Arabic) ????? ?????????? - ??????? ...

  1. MRSA - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... sharing features on this page, please enable JavaScript. Arabic (???????) Bosnian (Bosanski) Chinese - Simplified (????) Chinese - Traditional ( ... Soomaali) Spanish (español) Tagalog (Tagalog) Vietnamese (Tiê?ng Viê?t) Arabic (???????) MRSA (Methicillin Resistant Staphylococcus Aureus) (Arabic) ????????? ...

  2. Weight Control - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... sharing features on this page, please enable JavaScript. Arabic (???????) Chinese - Simplified (????) Chinese - Traditional (????) French ( ... ???????) Somali (af Soomaali) Spanish (español) Ukrainian (??????????) Arabic (???????) Avoiding Weight Gain When Quitting Tobacco (Arabic) ...

  3. Mining MEDLINE for the Treatment of Osteoporosis

    Microsoft Academic Search

    Pinar Yildirim; Çinar Çeken; Reza Hassanpour; Sadik Esmelioglu; Mehmet Resit Tolun

    In this paper, we consider the importance of osteoporosis disease in terms of medical research and pharmaceutical industry\\u000a and we introduce a knowledge discovery approach regarding the treatment of osteoporosis from a historical perspective. Osteoporosis\\u000a is a systemic skeletal disease in which osteoporotic fractures are associated with substantial morbidity and mortality and\\u000a impaired quality of life. Osteoporosis has also higher

  4. Healthline | NIH MedlinePlus the Magazine

    MedlinePLUS

    ... You Need to Know About Prescription and Illicit Drug Abuse A new health topic page on NIHSeniorHealth.gov ... to watch for and what to do about drug abuse among older Americans. National surveys find more Baby ...

  5. Healthlines | NIH MedlinePlus the Magazine

    MedlinePLUS

    ... Healthlines Past Issues / Fall 2014 Table of Contents Ebola Virus Disease Information The outbreak of Ebola virus disease in West Africa may have you looking for accurate and updated information. The Ebola topic page on Medlineplus.gov rounds up helpful ...

  6. Healthlines | NIH MedlinePlus the Magazine

    MedlinePLUS

    ... report promising results in prevention and treatment of Ebola virus disease (from left) NIH Director Dr. Francis ... Gallin exit the Clinical Center with recently discharged Ebola patient Nina Pham (next to Dr. Fauci). NIH's ...

  7. Genital Warts - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... List of All Topics All Genital Warts - Multiple Languages To use the sharing features on this page, please enable JavaScript. Amharic (amarunya) Oromo (Afaan Oromo) Spanish (español) Amharic (amarunya) ...

  8. Plague - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... XYZ List of All Topics All Plague - Multiple Languages To use the sharing features on this page, please enable JavaScript. Amharic (amarunya) Hmong (Hmoob) Spanish (español) Amharic (amarunya) Plague ...

  9. Tick Bites - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... List of All Topics All Tick Bites - Multiple Languages To use the sharing features on this page, please enable JavaScript. Amharic (amarunya) Hmong (Hmoob) Spanish (español) Amharic (amarunya) Tularemia ...

  10. Gonorrhea - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... XYZ List of All Topics All Gonorrhea - Multiple Languages To use the sharing features on this page, please enable JavaScript. Amharic (amarunya) Oromo (Afaan Oromo) Spanish (español) Amharic (amarunya) ...

  11. Effect of rapid HIV testing on HIV incidence and services in populations at high risk for HIV exposure: an equity-focused systematic review

    PubMed Central

    Pottie, Kevin; Medu, Olanrewaju; Welch, Vivian; Dahal, Govinda P; Tyndall, Mark; Rader, Tamara; Wells, George

    2014-01-01

    Objective To assess the effects of rapid voluntary counselling and testing (VCT) for HIV on HIV incidence and uptake of HIV/AIDS services in people at high risk for HIV exposure. Design Cochrane systematic review and meta-analysis. Data sources We searched PubMed, EMBASE, AIDSearch, LILACS, Global Health, Medline Africa, PsychInfo, CINAHL, Cochrane CENTRAL, Cochrane HIV/AIDS Group Specialized Register and grey literature from 1 January 2001 to 5 June 2014 without language restriction. Data selection We included controlled studies that compared rapid VCT with conventional testing among people at risk for HIV exposure. Data extraction Two reviewers extracted data. We used Cochrane risk of bias tool and GRADE criteria: risk of bias, inconsistency, indirectness, imprecision and publication bias. For observational studies we used the Newcastle-Ottawa Scale. We used the PRISMA-Equity reporting guideline. Results From 2441 articles, we included 8 randomised controlled trials and 5 observational studies. Rapid VCT was associated with a threefold increase in HIV-testing uptake (relative risk (RR)=2.95 95% CI 1.69 to 5.16) and a twofold increase in the receipt of test results (RR=2.14, 95% CI 1.08 to 4.24). Women accepted testing more often than men in rapid VCT arm, but no differences in effect for age or socioeconomic status. Observational studies also showed rapid VCT led to higher rates of uptake of testing. Heterogeneity was high. A cluster-randomised trial reported an 11% reduction in HIV incidence in intervention communities (RR=0.89, 95% CI=0.63 to 1.24) over 3?years trial. Conclusions Rapid VCT in health facilities and communities was associated with a large increase in HIV-testing uptake and receipt of results. This has implications for WHO guidelines. The routine use of rapid VCT may also help avoid human rights violations among marginalised populations where testing may occur without informed consent and where existing stigma may create barriers to testing. PMID:25510889

  12. Yohimbe

    MedlinePLUS

    ... E-mail: info@nccih.nih.gov PubMed® A service of the National Library of Medicine (NLM), PubMed® contains publication information and ( ... supporting research, sharing research results, and educating the public. Its resources include publications (such ... Library of Medicine's MedlinePlus Yohimbe Listing: www.nlm.nih. ...

  13. Evening Primrose Oil

    MedlinePLUS

    ... E-mail: info@nccih.nih.gov PubMed® A service of the National Library of Medicine (NLM), PubMed® contains publication information and ( ... supporting research, sharing research results, and educating the public. Its resources include publications (such as ... of Medicine's MedlinePlus Evening Primrose Oil Listing: www. ...

  14. Asian Ginseng

    MedlinePLUS

    ... E-mail: info@nccih.nih.gov PubMed® A service of the National Library of Medicine (NLM), PubMed® contains publication information and ( ... supporting research, sharing research results, and educating the public. Its resources include publications (such ... Library of Medicine's MedlinePlus Ginseng Listing: www.nlm.nih. ...

  15. Flaxseed and Flaxseed Oil

    MedlinePLUS

    ... E-mail: info@nccih.nih.gov PubMed® A service of the National Library of Medicine (NLM), PubMed® contains publication information and ( ... supporting research, sharing research results, and educating the public. Its resources include publications (such ... Library of Medicine's MedlinePlus Flaxseed Listing: www.nlm.nih. ...

  16. Feverfew

    MedlinePLUS

    ... E-mail: info@nccih.nih.gov PubMed® A service of the National Library of Medicine (NLM), PubMed® contains publication information and ( ... supporting research, sharing research results, and educating the public. Its resources include publications (such ... Library of Medicine's MedlinePlus Feverfew Listing: www.nlm.nih. ...

  17. Valerian

    MedlinePLUS

    ... E-mail: info@nccih.nih.gov PubMed® A service of the National Library of Medicine (NLM), PubMed® contains publication information and ( ... supporting research, sharing research results, and educating the public. Its resources include publications (such ... Library of Medicine's MedlinePlus Valerian Listing: www.nlm.nih. ...

  18. Noni

    MedlinePLUS

    ... E-mail: info@nccih.nih.gov PubMed® A service of the National Library of Medicine (NLM), PubMed® contains publication information and ( ... supporting research, sharing research results, and educating the public. Its resources include publications (such as ... Library of Medicine's MedlinePlus Noni Listing: www.nlm.nih. ...

  19. Saw Palmetto

    MedlinePLUS

    ... E-mail: info@nccih.nih.gov PubMed® A service of the National Library of Medicine (NLM), PubMed® contains publication information and ( ... supporting research, sharing research results, and educating the public. Its resources include publications (such ... Library of Medicine's MedlinePlus Saw Palmetto Listing: www.nlm. ...

  20. Bilberry

    MedlinePLUS

    ... E-mail: info@nccih.nih.gov PubMed® A service of the National Library of Medicine (NLM), PubMed® contains publication information and ( ... supporting research, sharing research results, and educating the public. Its resources include publications (such ... Library of Medicine's MedlinePlus Bilberry Listing: www.nlm.nih. ...