Sample records for pubmed medline cochrane

  1. Searching MEDLINE via PubMed.

    PubMed

    Delwiche, Frances A

    2008-01-01

    As the volume of biomedical literature has increased, so have the number and complexity of databases that index it. Learning to conduct an efficient literature search in an online database is an essential skill for today's clinical laboratory scientist. This article describes basic and advanced strategies for searching PubMed and the use of specialized features including MyNCBI. PMID:18335860

  2. Recherche bibliographique en biologie et mdecine : du bon usage de Medline PubMed...

    E-print Network

    Paris-Sud XI, Université de

    nombre annuel de requêtes sur Medline PubMed est passé de sept millions en 1998, à plus de 220 millions26/05/11 Recherche bibliographique en biologie et médecine : du bon usage de Medline Pub disponibles dans le domaine bio-médical (Embase, Current Contents, Biosis...), Medline PubMed, de par la

  3. PubMed alternatives to search MEDLINE: an environmental scan.

    PubMed

    Keepanasseril, Arun

    2014-01-01

    The prime objective of this article is to introduce the newer methods to access, search and process MEDLINE citations. It also aims to provide a brief overview of each service's salient features. A targeted search was conducted in MEDLINE through the OVID gateway. This was followed with a search in Google Scholar as well as Google and Bing. Ninety-two web-based services that can be used to search MEDLINE were identified. The list was shortened to 24 by applying a set of relevancy criteria to select those services more relevant to general medical and dental users. Salient features of the selected services are outlined and a use case based classification of the system has been proposed to help dental practitioners and researchers select the appropriate service for a given purpose. PMID:25307922

  4. Searching the MEDLINE literature database through PubMed: a short guide.

    PubMed

    Motschall, Edith; Falck-Ytter, Yngve

    2005-10-01

    The Medline database from the National Library of Medicine (NLM) contains more than 12 million bibliographic citations from over 4,600 international biomedical journals. One of the interfaces for searching Medline is PubMed, provided by the NLM for free access via the Internet (www.pubmed.gov). Also searchable with the PubMed interface are non-Medline citations, i.e. articles supplied by publishers to the NLM. Direct access to an electronic full text version is also possible if the article is available from a publisher or institution participating in Linkout (www.ncbi.nlm.nih.gov/entrez/linkout/). Some publishers provide free access to their journals. Other journals require an online license and are fee based. The following example demonstrates some of the most important search functions in PubMed. We will start out with a fast and simple approach without the use of specific searching techniques and then continue with a more sophisticated search that requires the knowledge of Medline search functions. This example will show how the application of Medline search tools and how the use of the controlled vocabulary of 'Medical Subject Headings' (MeSH) will influence the results in comparison with the fast and simple approach. Let's try to find the best evidence to answer the following question: Is a 30-year-old man with typical acid reflux symptoms for many years (gastroesophageal reflux disease, GERD) more likely to develop esophageal cancer than people without reflux symptoms? This question can be split into several components: -a patient with reflux symptoms (GERD), -esophageal cancer: etiology, risk, -study design for etiology studies: cohort studies, case-control studies. PMID:16186693

  5. Retrieval comparison of EndNote to search MEDLINE (Ovid and PubMed) versus searching them directly.

    PubMed

    Gall, Carole; Brahmi, Frances A

    2004-01-01

    Using EndNote version 7.0, the authors tested the search capabilities of the EndNote search engine for retrieving citations from MEDLINE for importation into EndNote, a citation management software package. Ovid MEDLINE and PubMed were selected for the comparison. Several searches were performed on Ovid MEDLINE and PubMed using EndNote as the search engine, and the same searches were run on both Ovid and PubMed directly. Findings indicate that it is preferable to search MEDLINE directly rather than using EndNote. The publishers of EndNote do warn its users about the limitations of their product as a search engine when searching external databases. In this article, the limitations of EndNote as a search engine for searching MEDLINE were explored as related to MeSH, non-MeSH, citation verification, and author searching. PMID:15364649

  6. All Information Is Not Equal: Using the Literature Databases PubMed and The Cochrane Library for Identifying the Evidence on Granulocyte Transfusion Therapy

    PubMed Central

    Metzendorf, Maria-Inti; Schulz, Manuela; Braun, Volker

    2014-01-01

    Summary To be able to take well-informed decisions or carry out sound research, clinicians and researchers alike require specific information seeking skills matching their respective information needs. Biomedical information is traditionally available via different literature databases. This article gives an introduction to two diverging sources, PubMed (23 million references) and The Cochrane Library (800,000 references), both of which offer sophisticated instruments for searching an increasing amount of medical publications of varied quality and ambition. Whereas PubMed as an unfiltered source of primary literature comprises all different kinds of publication types occurring in academic journals, The Cochrane Library is a pre-filtered source which offers access to either synthesized publication types or critically appraised and carefully selected references. A search approach has to be carried out deliberately and requires a good knowledge on the scope and features of the databases as well as on the ability to build a search strategy in a structured way. We present a specific and a sensitive search approach, making use of both databases within two application case scenarios in order to identify the evidence on granulocyte transfusions for infections in adult patients with neutropenia. PMID:25538539

  7. A quiver full of arrows: recommended Web-based tutorials for PubMed, PowerPoint, Ovid MEDLINE, and FrontPage.

    PubMed

    Dixon, Laura A

    2002-01-01

    Librarians often are responsible for instructing their patrons in the use of various databases and popular software packages. When this instruction can't be provided through face-to-face contact, Web-based tutorials can be useful tools to bridge the information gap. This article recommends Web-based tutorials for PubMed, Ovid MEDLINE, PowerPoint, and FrontPage. PMID:12017015

  8. Agreement between Medline searches using the Medline-CD-Rom and Internet PubMed, BioMedNet, Medscape and Gateway search-engines

    Microsoft Academic Search

    Rosa Ángela Caro-Rojas; Javier H. Eslava-Schmalbach

    2005-01-01

    Objective To compare the information obtained from the Medline database using Internet commercial search engines with that obtained from a compact disc (Medline-CD). Methods An agreement study was carried out based on 101 clinical sce- narios provided by specialists in internal medicine, pharmacy, gynaecology- obstetrics, surgery and paediatrics. 175 search strategies were employed using the connector AND plus text within

  9. PUBMED OR NLM GATEWAY

    EPA Science Inventory

    PubMed, a service of the National Library of Medicine, provides access to over 12 million MEDLINE citations back to the mid-1960's and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. PubMed was design...

  10. PubMed contains all of MEDLINE (1966-present), OLDMEDLINE (1946-1965), PubMed in-process records (new citations not yet fully indexed) and some additional non-MEDLINE citations. It is the primary database for researchers in the fields of biochemistry, mol

    E-print Network

    California at Berkeley, University of

    BASIC SEARCH TECHNIQUES PubMed searching is easy. Just enter your search terms in the search box to additional searching options. Keyword Searching Enter one or more keywords (e.g., molecular motors) in the search box and click Search. PubMed automatically combines (ANDs) significant terms together using

  11. Evaluation of PubMed filters used for evidence-based searching: validation using relative recall

    PubMed Central

    Hoogendam, Arjen; de Vries Robbé, Pieter F.; Stalenhoef, Anton F.H.; Overbeke, A. John P.M.

    2009-01-01

    Objectives: The research sought to determine the value of PubMed filters and combinations of filters in literature selected for systematic reviews on therapy-related clinical questions. Methods: References to 35,281 included and 48,514 excluded articles were extracted from 2,629 reviews published prior to January 2008 in the Cochrane Database of Systematic Reviews and sent to PubMed with and without filters. Sensitivity, specificity, and precision were calculated from the percentages of unfiltered and filtered references retrieved for each review and averaged over all reviews. Results: Sensitivity of the Sensitive Clinical Queries filter was reasonable (92.7%, 92.1–93.3); specificity (16.1%, 15.1–17.1) and precision were low (49.5%, 48.5–50.5). The Specific Clinical Queries and the Single Term Medline Specific filters performed comparably (sensitivity, 78.2%, 77.2–79.2 vs. 78.0%; 77.0–79.0; specificity, 52.0%, 50.8–53.2 vs. 52.3%, 51.1–53.5; precision, 60.4%, 59.4–61.4 vs. 60.6%, 59.6–61.6). Combining the Abridged Index Medicus (AIM) and Single Term Medline Specific (65.2%, 63.8–66.6), Two Terms Medline Optimized (64.2%, 62.8–65.6), or Specific Clinical Queries filters (65.0%, 63.6–66.4) yielded the highest precision. Conclusions: Sensitive and Specific Clinical Queries filters used to answer questions about therapy will result in a list of clinical trials but cannot be expected to identify only methodologically sound trials. The Specific Clinical Queries filters are not suitable for questions regarding therapy that cannot be answered with randomized controlled trials. Combining AIM with specific PubMed filters yields the highest precision in the Cochrane dataset. PMID:19626144

  12. PubMed: National Library of Medicine

    NSDL National Science Digital Library

    1997-01-01

    The US National Library of Medicine has made its searchable MEDLINE database freely available to all Americans. This site provides searchable access to over 8.5 million MEDLINE and PreMEDLINE citations. Users can also search molecular biology databases from the National Center for Biotechnology Information's Entrez system. Entrez, integrates information from a number of databases (nucleotide sequences, protein sequences, macromolecular structures, whole genomes, and MEDLINE) at the National Center for Biotechnology Information (NCBI). Entrez provides access "to over 10 million citations in MEDLINE, PreMEDLINE, and other related databases, with links to participating online journals." Its new single search interface includes four new menus that display field limits, indexes, search history (active for one hour), and a clipboard where users can store up to 500 items for one hour.A journal browser, which allows users to find articles based on the journals they appear in, and clinical alert notices are also featured at PubMed.

  13. Methods to improve recruitment to randomised controlled trials: Cochrane systematic review and meta-analysis

    PubMed Central

    Treweek, Shaun; Lockhart, Pauline; Pitkethly, Marie; Cook, Jonathan A; Kjeldstrøm, Monica; Johansen, Marit; Taskila, Taina K; Sullivan, Frank M; Wilson, Sue; Jackson, Catherine; Jones, Ritu; Mitchell, Elizabeth D

    2013-01-01

    This review is an abridged version of a Cochrane Review previously published in the Cochrane Database of Systematic Reviews 2010, Issue 4, Art. No.: MR000013 DOI: 10.1002/14651858.MR000013.pub5 (see www.thecochranelibrary.com for information). Cochrane Reviews are regularly updated as new evidence emerges and in response to feedback, and Cochrane Database of Systematic Reviews should be consulted for the most recent version of the review. Objective To identify interventions designed to improve recruitment to randomised controlled trials, and to quantify their effect on trial participation. Design Systematic review. Data sources The Cochrane Methodology Review Group Specialised Register in the Cochrane Library, MEDLINE, EMBASE, ERIC, Science Citation Index, Social Sciences Citation Index, C2-SPECTR, the National Research Register and PubMed. Most searches were undertaken up to 2010; no language restrictions were applied. Study selection Randomised and quasi-randomised controlled trials, including those recruiting to hypothetical studies. Studies on retention strategies, examining ways to increase questionnaire response or evaluating the use of incentives for clinicians were excluded. The study population included any potential trial participant (eg, patient, clinician and member of the public), or individual or group of individuals responsible for trial recruitment (eg, clinicians, researchers and recruitment sites). Two authors independently screened identified studies for eligibility. Results 45 trials with over 43?000 participants were included. Some interventions were effective in increasing recruitment: telephone reminders to non-respondents (risk ratio (RR) 1.66, 95% CI 1.03 to 2.46; two studies, 1058 participants), use of opt-out rather than opt-in procedures for contacting potential participants (RR 1.39, 95% CI 1.06 to 1.84; one study, 152 participants) and open designs where participants know which treatment they are receiving in the trial (RR 1.22, 95% CI 1.09 to 1.36; two studies, 4833 participants). However, the effect of many other strategies is less clear, including the use of video to provide trial information and interventions aimed at recruiters. Conclusions There are promising strategies for increasing recruitment to trials, but some methods, such as open-trial designs and opt-out strategies, must be considered carefully as their use may also present methodological or ethical challenges. Questions remain as to the applicability of results originating from hypothetical trials, including those relating to the use of monetary incentives, and there is a clear knowledge gap with regard to effective strategies aimed at recruiters. PMID:23396504

  14. MEDLINE PLUS

    EPA Science Inventory

    MEDLINE plus is the National Library of Medicine's web site for consumer health information. MEDLINE plus has extensive information from the National Institutes of Health and other trusted sources on over 600 diseases and conditions. There are also lists of hospitals and physicia...

  15. MINING MEDLINE: ABSTRACTS, SENTENCES, OR PHRASES? , D. BERLEANTa,d

    E-print Network

    Wurtele, Eve Syrkin

    deep, fully automated literature analysis via natural language understanding (NLU) is an intriguing, sentences, or phrases. The most basic way to "mine" MEDLINE is simply to use the PUBMED Web interface.8

  16. McMaster Premium LiteratUre Service (PLUS) performed well for identifying new studies for updated Cochrane reviews

    Microsoft Academic Search

    Brian J. Hemens; R. Brian Haynes

    ObjectiveWe compared the performance of McMaster Premium LiteratUre Service (PLUS) and Clinical Queries (CQs) to that of the Cochrane Controlled Trials Register, MEDLINE, and EMBASE for locating studies added during an update of reviews.

  17. PubMed Help PubMed comprises over 23 million citations for biomedical literature from MEDLINE, life

    E-print Network

    Levin, Judith G.

    the key concepts for your search. 2 Enter the terms (or key concepts) in the search box. 3 Suggestions by Bonnie W. Ramsey about gene therapy for cystic fibrosis enter the following search terms into the search will display as you type your search terms. Click Turn off to temporarily disable the autocomplete feature. 4

  18. Treatment of diffuse proliferative lupus nephritis: a meta-analysis of randomized controlled trials 1 1 This review is excerpted from a Cochrane Review in The Cochrane Library 2004, Issue 1 (“Treatment for Lupus Nephritis”; http:\\/\\/www.update-software.com\\/cochrane\\/). Cochrane Reviews are regularly updated as new evidence emerges and in response to comments and criticisms, and The Cochrane Library should be consulted for the most recent version of the Review

    Microsoft Academic Search

    Robert S Flanc; Matthew A Roberts; Giovanni F. M Strippoli; Steven J Chadban; Peter G Kerr; Robert C Atkins

    2004-01-01

    Background: In this systematic review of randomized controlled trials (RCTs), we assess the benefits and harm of current treatments for diffuse proliferative lupus nephritis (DPLN). Methods: The Cochrane Controlled Trial Registry, MEDLINE, and EMBASE were searched for RCTs of treatment for DPLN. All available RCTs of patients with biopsy-proven DPLN were included, and data were extracted for overall mortality, end-stage

  19. McMaster Premium Literature Service (Plus) Performs Well for Identifying New Studies to be Included in Updated Cochrane Systematic Reviews

    Microsoft Academic Search

    Briam Hemens

    2010-01-01

    Objective: We compared the performance of PLUS to that ofthe Cochrane Trial Registry (CCTR), Medline and EMBASE for locating studies added during an update of Cochrane Systematic reviews. We investigated the effect of excluding studies not found in PLUS on meta-analysis results.\\u000aStudy Design and Setting: A sample of new studies in updated Cochrane Systematic Reviews was used to establish

  20. MedlinePlus Connect

    MedlinePLUS

    ... Connect also accepts text strings for medication requests Laboratory Tests • LOINC® (Logical Observation Identifiers Names and Codes) MedlinePlus ... How does MedlinePlus Connect work? Problems/Diagnoses Medications Laboratory Tests

  1. Medicinal Herbs for Hepatitis C Virus Infection: A Cochrane Hepatobiliary Systematic Review of Randomized Trials

    Microsoft Academic Search

    Jianping Liu; Eric Manheimer; Kiichiro Tsutani; Christian Gluud

    2003-01-01

    OBJECTIVE:The aim of this study was to assess beneficial and harmful effects of medicinal herbs for hepatitis C virus (HCV) infection.METHODS:The databases of the Cochrane Collaboration, MEDLINE, EMBASE, and BIOSIS were searched combined with manual searches of five Chinese and one Japanese journals. We included randomized trials comparing medicinal herbs with placebo, no intervention, nonspecific treatment, other herbs, or interferon

  2. Alpha-glucosidase inhibitors for patients with type 2 diabetes: results from a Cochrane systematic review and meta-analysis

    Microsoft Academic Search

    FLORIS A. VAN DE LAAR; PETER L. LUCASSEN; REINIER P. AKKERMANS; ELOY H. VAN DE LISDONK; G. E. H. M. Rutten; CHRIS VAN WEEL

    2005-01-01

    OBJECTIVE: To review the effects of monotherapy with alpha-glucosidase inhibitors (AGIs) for patients with type 2 diabetes, with respect to mortality, morbidity, glycemic control, insulin levels, plasma lipids, body weight, and side effects. RESEARCH DESIGN AND METHODS: We systematically searched the Cochrane Central register of Controlled Trials, MEDLINE, EMBASE, Current Contents, LILACS, databases of ongoing trials, and reference lists, and

  3. Predicting clicks of PubMed articles

    PubMed Central

    Mao, Yuqing; Lu, Zhiyong

    2013-01-01

    Predicting the popularity or access usage of an article has the potential to improve the quality of PubMed searches. We can model the click trend of each article as its access changes over time by mining the PubMed query logs, which contain the previous access history for all articles. In this article, we examine the access patterns produced by PubMed users in two years (July 2009 to July 2011). We explore the time series of accesses for each article in the query logs, model the trends with regression approaches, and subsequently use the models for prediction. We show that the click trends of PubMed articles are best fitted with a log-normal regression model. This model allows the number of accesses an article receives and the time since it first becomes available in PubMed to be related via quadratic and logistic functions, with the model parameters to be estimated via maximum likelihood. Our experiments predicting the number of accesses for an article based on its past usage demonstrate that the mean absolute error and mean absolute percentage error of our model are 4.0% and 8.1% lower than the power-law regression model, respectively. The log-normal distribution is also shown to perform significantly better than a previous prediction method based on a human memory theory in cognitive science. This work warrants further investigation on the utility of such a log-normal regression approach towards improving information access in PubMed. PMID:24551386

  4. The absolute spectrophotometric catalog by Anita Cochran

    NASA Astrophysics Data System (ADS)

    Burnashev, V. I.; Burnasheva, B. A.; Ruban, E. V.; Hagen-Torn, E. I.

    2014-06-01

    The absolute spectrophotometric catalog by Anita Cochran is presented in a machine-readable form. The catalog systematizes observations acquired at the McDonald Observatory in 1977-1978. The data are compared with other sources, in particular, the calculated broadband stellar magnitudes are compared with photometric observations by other authors, to show that the observational data given in the catalog are reliable and suitable for a variety of applications. Observations of variable stars of different types make Cochran's catalog especially valuable.

  5. About CAM on PubMed

    MedlinePLUS

    ... search instructions PubMed Disclaimer and Copyright Notice Home Home Page Contact Us Site Map FAQs Accessibility Web Site Policies Privacy Policy ... page last modified March 03, 2015 Share This Page: E-mail Twitter Read our ... FOIA Site Map Contact Us Change text size: S M L ...

  6. MEDLINE (MEDLARS ONLINE)

    EPA Science Inventory

    MEDLINE (MEDlars onLINE) is the National Library of Medicines (NLM) premier bibliographic database covering the fields of medicine, nursing, dentistry, veterinary medicine, the health care system, and the preclinical sciences. It contains bibliographic citations (e.g., authors, ...

  7. Ribavirin Monotherapy for Chronic Hepatitis C Infection: A Cochrane HepatoBiliary Group Systematic Review and Meta-Analysis of Randomized Trials

    Microsoft Academic Search

    Jesper Brok; Lise L. Gluud; Christian Gluud

    2006-01-01

    OBJECTIVES:Adding ribavirin to interferon improves treatment response for patients with chronic hepatitis C, but the effects of ribavirin monotherapy are unclear. We conducted a systematic review to assess the benefits and harms of ribavirin monotherapy for patients with chronic hepatitis C.METHODS:Randomized trials were identified through the Cochrane Hepato-Biliary Group Controlled Trials Register, The Cochrane Library, MEDLINE, and EMBASE (last search

  8. Multivariate Versions of Cochran's Theorems II

    Microsoft Academic Search

    C. S. Wong; T. H. Wang

    1993-01-01

    A general easily checkable Cochran theorem is obtained for a normal random operator Y. This result does not require that the covariance, [Sigma]Y, of Y is nonsingular or is of the usual form A [circle times operator] [Sigma] ; nor does it assume that the mean, [mu], of Y is equal to zero. Indeed, {Y'WiY} (with nonnegative definite Wi's) is

  9. Dialogues with Marilyn Cochran-Smith

    ERIC Educational Resources Information Center

    Fiorentini, Dario; Crecci, Vanessa Moreira

    2015-01-01

    For more than 30 years, Dr. Marilyn Cochran-Smith has developed and directed research and contributed to publications about education and "practitioner research," especially about teachers' research and learning in inquiry communities. Her primary topics are inquiry communities, teacher research, teacher education for social…

  10. SPELLING CORRECTION IN THE PUBMED SEARCH ENGINE.

    PubMed

    Wilbur, W John; Kim, Won; Xie, Natalie

    2006-11-01

    It is known that users of internet search engines often enter queries with misspellings in one or more search terms. Several web search engines make suggestions for correcting misspelled words, but the methods used are proprietary and unpublished to our knowledge. Here we describe the methodology we have developed to perform spelling correction for the PubMed search engine. Our approach is based on the noisy channel model for spelling correction and makes use of statistics harvested from user logs to estimate the probabilities of different types of edits that lead to misspellings. The unique problems encountered in correcting search engine queries are discussed and our solutions are outlined. PMID:18080004

  11. A Cochrane systematic review finds tongue scrapers have short-term efficacy in controlling halitosis.

    PubMed

    Outhouse, Trent L; Fedorowicz, Zbigniew; Keenan, James V; Al-Alawi, Rashad

    2006-01-01

    The Cochrane systematic review promotes evidence-based outcome studies. This review was conducted to determine reliable evidence concerning the effectiveness of tongue scraping or cleaning, compared with other interventions for controlling halitosis. A competent search strategy was developed and used across several databases--including the Cochrane Oral Health Group Trials Register, the Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, and Google Scholar--to identify randomized controlled trials that compared different methods of tongue cleaning to reduce mouth odor in adults with halitosis. Methodological quality of studies was assessed based on criteria defined by the Cochrane Collaboration. Clinical outcome (expressed in terms of a reduction in mouth odor in adults with halitosis) was examined. The review included two trials involving a total of 40 participants. Based on the independent data from these two trials, the tongue cleaner or the tongue scraper demonstrated a statistically significant difference in reducing levels of volatile sulfur compounds (VSCs) when compared with the toothbrush. The findings indicate a small but statistically significant difference in reduction of VSC levels when tongue scrapers or cleaners, rather than toothbrushes, are used to reduce halitosis in adults. PMID:17004573

  12. Studying PubMed usages in the field for complex problem solving: Implications for tool design

    PubMed Central

    Song, Jean; Tonks, Jennifer Steiner; Meng, Fan; Xuan, Weijian; Ameziane, Rafiqa

    2012-01-01

    Many recent studies on MEDLINE-based information seeking have shed light on scientists’ behaviors and associated tool innovations that may improve efficiency and effectiveness. Few if any studies, however, examine scientists’ problem-solving uses of PubMed in actual contexts of work and corresponding needs for better tool support. Addressing this gap, we conducted a field study of novice scientists (14 upper level undergraduate majors in molecular biology) as they engaged in a problem solving activity with PubMed in a laboratory setting. Findings reveal many common stages and patterns of information seeking across users as well as variations, especially variations in cognitive search styles. Based on findings, we suggest tool improvements that both confirm and qualify many results found in other recent studies. Our findings highlight the need to use results from context-rich studies to inform decisions in tool design about when to offer improved features to users. PMID:24376375

  13. Exploring MEDLINE space with random indexing and pathfinder networks.

    PubMed

    Cohen, Trevor

    2008-01-01

    The integration of disparate research domains is a prerequisite for the success of the translational science initiative. MEDLINE abstracts contain content from a broad range of disciplines, presenting an opportunity for the development of methods able to integrate the knowledge they contain. Latent Semantic Analysis (LSA) and related methods learn human-like associations between terms from unannotated text. However, their computational and memory demands limits their ability to address a corpus of this size. Furthermore, visualization methods previously used in conjunction with LSA have limited ability to define the local structure of the associative networks LSA learns. This paper explores these issues by (1) processing the entire MEDLINE corpus using Random Indexing, a variant of LSA, and (2) exploring learned associations using Pathfinder Networks. Meaningful associations are inferred from MEDLINE, including a drug-disease association undetected by PUBMED search. PMID:18999236

  14. Exploring MEDLINE Space with Random Indexing and Pathfinder Networks

    PubMed Central

    Cohen, Trevor

    2008-01-01

    The integration of disparate research domains is a prerequisite for the success of the translational science initiative. MEDLINE abstracts contain content from a broad range of disciplines, presenting an opportunity for the development of methods able to integrate the knowledge they contain. Latent Semantic Analysis (LSA) and related methods learn human-like associations between terms from unannotated text. However, their computational and memory demands limits their ability to address a corpus of this size. Furthermore, visualization methods previously used in conjunction with LSA have limited ability to define the local structure of the associative networks LSA learns. This paper explores these issues by (1) processing the entire MEDLINE corpus using Random Indexing, a variant of LSA, and (2) exploring learned associations using Pathfinder Networks. Meaningful associations are inferred from MEDLINE, including a drug-disease association undetected by PUBMED search. PMID:18999236

  15. Meta-analysis and The Cochrane Collaboration: 20 years of the Cochrane Statistical Methods Group

    PubMed Central

    2013-01-01

    The Statistical Methods Group has played a pivotal role in The Cochrane Collaboration over the past 20 years. The Statistical Methods Group has determined the direction of statistical methods used within Cochrane reviews, developed guidance for these methods, provided training, and continued to discuss and consider new and controversial issues in meta-analysis. The contribution of Statistical Methods Group members to the meta-analysis literature has been extensive and has helped to shape the wider meta-analysis landscape. In this paper, marking the 20th anniversary of The Cochrane Collaboration, we reflect on the history of the Statistical Methods Group, beginning in 1993 with the identification of aspects of statistical synthesis for which consensus was lacking about the best approach. We highlight some landmark methodological developments that Statistical Methods Group members have contributed to in the field of meta-analysis. We discuss how the Group implements and disseminates statistical methods within The Cochrane Collaboration. Finally, we consider the importance of robust statistical methodology for Cochrane systematic reviews, note research gaps, and reflect on the challenges that the Statistical Methods Group faces in its future direction. PMID:24280020

  16. The Cochrane Library can answer your nursing care effectiveness questions.

    PubMed

    Forbes, Dorothy; Clark, Kathie

    2003-09-01

    Systematic reviews help nurses to manage the overwhelming volume of available information by synthesizing valid data from primary studies and summarizing the results of interventions. One reliable source of systematic reviews of healthcare interventions is the Cochrane Library. This paper briefly describes the Cochrane Collaboration and the Cochrane Library. It also encourages nurse clinicians and nurse administrators to use the Cochrane Library and encourages nurse researchers to contribute to the Cochrane Library by conducting systematic reviews in the field of nursing care effectiveness. PMID:14603566

  17. Dr. Felix's Free MEDLINE Page

    NSDL National Science Digital Library

    Perry, Helga J.

    1997-01-01

    If you need to search the National Medical Library's Medline database, Dr. Felix's Free Medline Page is a good place to start. This simple page is a comparison of twenty-eight web based services that offer free access to parts or all of Medline. For each service users can access information about database coverage, registration requirements, usage restrictions, and document delivery. Hypertext links are available from all of the services discussed. Dr. Felix is a quick and convenient way to launch a Medline session that can inform users of the possible limitations of their search right from the start.

  18. MedlinePlus: Diets

    NSDL National Science Digital Library

    In this section of their website, Medline Plus, a service of the U.S. National Library of Medicine and the National Institutes of Health, tackles the subject of diets. The information is divided up into half a dozen labeled boxes near the top of the page, and includes "Basics", "Research", "Learn More", and "Reference Shelf". Within these sections visitors can find links to information on "Nutrition", "Specific Conditions", "Journal Articles", "Dictionaries/Glossaries", and more. Many of the topics discussed throughout the categories is the safety of certain diets, such as the link "Nutrition for Weight Loss: What You Need to Know About Fad Diets", and "Are Detox Diets Safe?" found under the Teenagers category at the bottom of the page. Visitors interested in participating in clinical trials going on throughout the United States, can check out the links "ClinicalTrials.gov: Diet" and "ClinicalTrials.gov: Diet Therapy" under the category Clinical Trials.

  19. Medline Plus: Mammography

    NSDL National Science Digital Library

    MedLine Plus has been bringing helpful medical and health information to the web-browsing public for over a decade, and they have always been committed to providing information for educators as well. As one of their more specialized sections, the mammography site contains information on how to perform mammograms, including several interactive tutorials. First-time visitors will want look at the "Contents of this page" area, which allows them to move directly to sections such as "Clinical Trials", "Research", "Pictures/Diagrams", and "Overviews". One nice touch is that the site draws on materials culled from a number of high-quality sources, including the National Cancer Institute, the National Women's Health Information Center, and the American Cancer Society. Two other resources here that are worth special mention are the Atlas of the Body (provided by the American Medical Association) and the multilingual mammogram tutorials offered in Chinese, Tagalog, and Vietnamese.

  20. Medline Plus: Sports Injuries

    NSDL National Science Digital Library

    Exercising and playing sports can lead to a sound mind and body, but sports-related injuries can be frustrating for anyone. This very helpful site, offered as part of the Medline Plus series from the U.S. National Library of Medicine, contains dozens of fact sheets, media presentations, and other items regarding various sports injuries. Visitors who know exactly what they need can click on over to the "Related Topics" area on the right-hand side of the homepage, where they will find resources on everything from ankle injuries to general wellness. Their homepage also contains sections like "Basics", "Research", and "Multimedia & Cool Tools". Two items that are definitely worth checking out are the tennis elbow tutorial and the basic overview of sports injuries offered by the National Institute of Arthritis and Musculoskeletal and Skin Diseases.

  1. Bibliometric and content analysis of the Cochrane Complementary Medicine Field specialized register of controlled trials

    PubMed Central

    2013-01-01

    Background The identification of eligible controlled trials for systematic reviews of complementary and alternative medicine (CAM) interventions can be difficult. To increase access to these difficult to locate trials, the Cochrane Collaboration Complementary Medicine Field (CAM Field) has established a specialized register of citations of CAM controlled trials. The objective of this study is to describe the sources and characteristics of citations included in the CAM Field specialized register. Methods Between 2006 and 2011, regular searches for citations of CAM trials in MEDLINE and the Cochrane Central Register of Controlled Trials (CENTRAL) were supplemented with contributions of controlled trial citations from international collaborators. The specialized register was ‘frozen’ for analysis in 2011, and frequencies were calculated for publication date, language, journal, presence in MEDLINE, type of intervention, and type of medical condition. Results The CAM Field specialized register increased in size from under 5,000 controlled trial citations in 2006 to 44,840 citations in 2011. Most citations (60%) were from 2000 or later, and the majority (71%) were reported in English; the next most common language was Chinese (23%). The journals with the greatest number of citations were CAM journals published in Chinese and non-CAM nutrition journals published in English. More than one-third of register citations (36%) were not indexed in MEDLINE. The most common CAM intervention type in the register was non-vitamin, non-mineral dietary supplements (e.g., glucosamine, fish oil) (34%), followed by Chinese herbal medicines (e.g., Astragalus membranaceus, Schisandra chinensis) (27%). Conclusions The availability of the CAM Field specialized register presents both opportunities and challenges for CAM systematic reviewers. While the register provides access to thousands of difficult to locate trial citations, many of these trials are of low quality and may overestimate treatment effects. When including these trials in systematic reviews, adequate analysis of their risk of bias is of utmost importance. PMID:23826877

  2. How to improve your PubMed/MEDLINE searches: 1. background and basic searching.

    PubMed

    Fatehi, Farhad; Gray, Leonard C; Wootton, Richard

    2013-12-01

    PubMed provides free access via the Internet to more than 23 million records, of which over 19 million are from the MEDLINE database of journal articles. PubMed also provides access to other databases, such as the NCBI Bookshelf. To perform a basic search, you can simply enter the search terms or the concept that you are looking for in the search box. However, taking care to clarify your key concepts may save much time later on, because a non-specific search is likely to produce an overwhelming number of result hits. One way to make your search more specific is to specify which field you want to search using field tags. By default, the results of a search are sorted by the date added to PubMed and displayed in summary format with 20 result hits (records) on each page. In summary format, the title of the article, list of authors, source of information (e.g., journal name followed by date of publication, volume, issue, pages) and the unique PubMed record number called the PubMed identifier (PMID) are shown. Although information is stored about the articles, PubMed/MEDLINE does not store the full text of the papers themselves. However, PubMedCentral (PMC) stores more than 2.8 million articles (roughly 10% of the articles in PubMed) and provides access to them for free to the users. PMID:24197398

  3. Bosnian and Herzegovinian medical scientists in PubMed database.

    PubMed

    Masic, Izet

    2013-01-01

    In this paper it is shortly presented PubMed as one of the most important on-line databases of the scientific biomedical literature. Also, the author has analyzed the most cited authors, professors of the medical faculties in Bosnia and Herzegovina, from the published papers in the biomedical journals abstracted and indexed in PubMed. PMID:24341067

  4. Medline Plus: Herbal Medicine

    NSDL National Science Digital Library

    From the world of Aloe Vera to yohimbe, this site leaves no herbal medicines unexplored. As part of the Medline Plus omnibus site which was created by the U.S. National Library of Medicine and the National Institutes of Health, this particular section covers many aspects of the world of herbal medicine. First-time visitors will want to start by looking over the background essays on the use of botanical dietary supplements offered from the Office of Dietary Supplements. After that, they should browse through sections that include "Basics", "Learn More", "Research", and "Reference Shelf". They can also just scroll down through the homepage, which includes overviews on the use of different herbs and supplements. Those persons looking for the latest information about research findings on herbs and topical treatments can look within the "Latest News" listings, which are updated frequently. Researchers will appreciate the inclusion of a "Clinical Trials" area which provides the latest information about ongoing clinical trials that draw on various aspects of herbal medicine.

  5. MedlinePlus FAQ: Mobile Version of MedlinePlus

    MedlinePLUS

    ... device to access MedlinePlus Mobile. Simply point the Web browser of any mobile device to http://m.medlineplus.gov/ . The mobile site has an improved design for easier use on mobile devices. The mobile ...

  6. Mobile MedlinePlus | NIH MedlinePlus Magazine

    MedlinePLUS

    ... Table of Contents Trusted medical information on your mobile phone http://m.medlineplus.gov Wondering what the side effects are for your new prescription? Go to Mobile MedlinePlus while you're waiting for the pharmacist ...

  7. Mobile MedlinePlus | NIH MedlinePlus the Magazine

    MedlinePLUS

    ... Table of Contents Trusted medical information on your mobile phone http://m.medlineplus.gov Wondering what the side effects are for your new prescription? Go to Mobile MedlinePlus ( http://m.medlineplus.gov ) while you're ...

  8. Context View from 11' on ladder across Cochran Street toward ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Context View from 11' on ladder across Cochran Street toward entrance to Bottle Village parcel. Senior apartments on west side and residential home on east side of parcel. Camera facing north northwest. - Grandma Prisbrey's Bottle Village, 4595 Cochran Street, Simi Valley, Ventura County, CA

  9. Cochrane methods - twenty years experience in developing systematic review methods

    PubMed Central

    2013-01-01

    This year, The Cochrane Collaboration reached its 20th anniversary. It has played a pivotal role in the scientific development of systematic reviewing and in the development of review methods to synthesize research evidence, primarily from randomized trials, to answer questions about the effects of healthcare interventions. We introduce a series of articles, which form this special issue describing the development of systematic review methods within The Cochrane Collaboration. We also discuss the impact of Cochrane Review methods, and acknowledge the breadth and depth of methods development within The Cochrane Collaboration as part of the wider context of evidence synthesis. We conclude by considering the future development of methods for Cochrane Reviews. PMID:24050381

  10. Health Topics: MedlinePlus

    MedlinePLUS

    ... features on this page, please enable JavaScript. Health Topics Read about symptoms, causes, treatment and prevention for ... illnesses, health conditions and wellness issues. MedlinePlus health topics are regularly reviewed, and links are updated daily. ...

  11. MedlinePlus FAQ: Framing

    MedlinePLUS

    ... as HealthDay. Our license agreements do not permit framing of their content from our site. For more ... privacy of our users, we have blocked all framing. Please see our guidelines on linking to MedlinePlus ...

  12. PubMed searches: overview and strategies for clinicians.

    PubMed

    Lindsey, Wesley T; Olin, Bernie R

    2013-04-01

    PubMed is a biomedical and life sciences database maintained by a division of the National Library of Medicine known as the National Center for Biotechnology Information (NCBI). It is a large resource with more than 5600 journals indexed and greater than 22 million total citations. Searches conducted in PubMed provide references that are more specific for the intended topic compared with other popular search engines. Effective PubMed searches allow the clinician to remain current on the latest clinical trials, systematic reviews, and practice guidelines. PubMed continues to evolve by allowing users to create a customized experience through the My NCBI portal, new arrangements and options in search filters, and supporting scholarly projects through exportation of citations to reference managing software. Prepackaged search options available in the Clinical Queries feature also allow users to efficiently search for clinical literature. PubMed also provides information regarding the source journals themselves through the Journals in NCBI Databases link. This article provides an overview of the PubMed database's structure and features as well as strategies for conducting an effective search. PMID:23442731

  13. Death, dying and informatics: misrepresenting religion on MedLine

    PubMed Central

    Rodríguez del Pozo, Pablo; Fins, Joseph J

    2005-01-01

    Background The globalization of medical science carries for doctors worldwide a correlative duty to deepen their understanding of patients' cultural contexts and religious backgrounds, in order to satisfy each as a unique individual. To become better informed, practitioners may turn to MedLine, but it is unclear whether the information found there is an accurate representation of culture and religion. To test MedLine's representation of this field, we chose the topic of death and dying in the three major monotheistic religions. Methods We searched MedLine using PubMed in order to retrieve and thematically analyze full-length scholarly journal papers or case reports dealing with religious traditions and end-of-life care. Our search consisted of a string of words that included the most common denominations of the three religions, the standard heading terms used by the National Reference Center for Bioethics Literature (NRCBL), and the Medical Subject Headings (MeSH) used by the National Library of Medicine. Eligible articles were limited to English-language papers with an abstract. Results We found that while a bibliographic search in MedLine on this topic produced instant results and some valuable literature, the aggregate reflected a selection bias. American writers were over-represented given the global prevalence of these religious traditions. Denominationally affiliated authors predominated in representing the Christian traditions. The Islamic tradition was under-represented. Conclusion MedLine's capability to identify the most current, reliable and accurate information about purely scientific topics should not be assumed to be the same case when considering the interface of religion, culture and end-of-life care. PMID:15992401

  14. Retrieval of diagnostic and treatment studies for clinical use through PubMed and PubMed's Clinical Queries filters

    Microsoft Academic Search

    Cynthia Lokker; R Brian Haynes; Nancy L Wilczynski; K Ann McKibbon; Stephen D Walter

    2011-01-01

    ObjectiveClinical Queries filters were developed to improve the retrieval of high-quality studies in searches on clinical matters. The study objective was to determine the yield of relevant citations and physician satisfaction while searching for diagnostic and treatment studies using the Clinical Queries page of PubMed compared with searching PubMed without these filters.Materials and methodsForty practicing physicians, presented with standardized treatment

  15. Neuraminidase inhibitors: the story behind the Cochrane review

    E-print Network

    Doshi, Peter

    Although billions have been spent on oseltamivir in the face of pandemic influenza, the team updating the Cochrane review of neuraminidase inhibitors in healthy adults found that the public evidence base for this global ...

  16. Visit the MedlinePlus Search Cloud | NIH MedlinePlus the Magazine

    MedlinePLUS

    ... please turn Javascript on. Visit the MedlinePlus Search Cloud Past Issues / Winter 2011 Table of Contents Free, ... Visit the new MedlinePlus Visit the MedlinePlus search cloud, featuring the top 100 search terms of the ...

  17. PubMed Central Canada: Beyond an Open Access Repository?

    ERIC Educational Resources Information Center

    Nariani, Rajiv

    2013-01-01

    PubMed Central Canada (PMC Canada) represents a partnership between the Canadian Institutes of Health Research (CIHR), the National Research Council's Canada Institute for Scientific and Technical Information (NRC-CISTI), and the National Library of Medicine of the US. The present study was done to gauge faculty awareness about the CIHR Policy on…

  18. PubMed Central: An Archive of Life Science Journals

    NSDL National Science Digital Library

    There has been an increased interest in open source publishing as of late, and the U.S government has gotten involved recently with the creation of PubMed Central (through the National Center for Biotechnology Information and the National Library of Medicine) in 2000. PubMed Central is a digital archive of life science journal literature which offers free and complete access to the contents of approximately 50 peer-reviewed journals, such as Applied and Environmental Microbiology, Dynamic Medicine, and the Journal of Bacteriology. The search engine is fairly straightforward, as users may elect to enter author names, journal titles in full, or by keywords. All told, PubMed currently contains many thousands of articles, many of which will be of great interest to researchers and students in these fields. Perhaps the most crucial features of PubMed are summarized in this passage from their overview section, which remarks thusly: "It also makes it possible to integrate the literature with a variety of other information resources such as sequence databases and other factual databases that are available to scientists, clinicians, and everyone else interested in the life sciences. The intentional and serendipitous discoveries that such links might foster excite us and stimulate us to move forward."

  19. PubMed advanced exercise: MeSH Searching

    E-print Network

    Rzepa, Henry S.

    achilles tendon and click Search. With MeSH searches, you enter only one search term at a time and you don can remove the need to enter multiple alternative terms to describe the same concept. For the following exercise, please search PubMed using: a) search terms that feature within the following

  20. Spelling correction in the PubMed search engine

    Microsoft Academic Search

    W. John Wilbur; Won Kim; Natalie Xie

    2006-01-01

    It is known that users of internet search engines often enter queries with misspellings in one or more search terms. Several web search engines make suggestions for correcting misspelled words, but the methods used are proprietary and unpublished to our knowledge. Here we describe the methodology we have developed to perform spelling correction for the PubMed search engine. Our approach

  1. MedlinePlus Connect: Email List

    MedlinePLUS

    ... Drugs & Supplements Videos & Cool Tools MedlinePlus Connect: Email List To use the sharing features on this page, ... health care providers. Join the MedlinePlus Connect discussion list to keep up with developments and exchange ideas ...

  2. MedlinePlus FAQ: RSS Service

    MedlinePLUS

    ... Do you have a Really Simple Syndication (RSS) feed for MedlinePlus? To use the sharing features on ... JavaScript. Answer: MedlinePlus offers a variety of RSS feeds to suit your particular interests. You can subscribe ...

  3. MedlinePlus Connect: Technical Information

    MedlinePLUS

    ... to keep you informed of updates and enhancements. Web Application The MedlinePlus Connect Web application responds to ... Connect response pages, visit the Web application demonstration . Web Service Using the MedlinePlus Connect Web service, a ...

  4. Best Available Evidence in Cochrane Reviews on Herbal Medicine?

    PubMed Central

    Davidson, Elyad; Vlachojannis, Julia; Cameron, Melainie; Chrubasik, Sigrun

    2013-01-01

    Cochrane reviews are considered by many to be the “gold standard” or the final word in medical conversation on a topic. We explored the eleven most relevant Cochrane reviews on herbal medicine and identified that frequently herbal medicines in the included studies had not been sufficiently well characterised. If data on the effects of the plant parts are unavailable, effects of co-active ingredients need to be considered and the plausibility of the study medications for the specific indications discussed. Effect sizes calculated from exploratory studies would be best used to determine the sample sizes required for future confirmatory studies, rather than as definitive reports of intervention effects. Reviews should be comprehensive, including discussion of putative adverse events and possible drug interactions. We suggest that the guidelines for preparing Cochrane reviews be revised and offer assistance in this task. PMID:23840246

  5. MedlinePlus Connect: Web Service

    MedlinePLUS

    MedlinePlus Connect: Web Service To use the sharing features on this page, please enable JavaScript. MedlinePlus Connect is available as a ... if you implement MedlinePlus Connect by contacting us . Web Service Overview The parameters for the Web service ...

  6. Author Name Disambiguation in MEDLINE

    PubMed Central

    TORVIK, VETLE I.; SMALHEISER, NEIL R.

    2009-01-01

    Background We recently described “Author-ity,” a model for estimating the probability that two articles in MEDLINE, sharing the same author name, were written by the same individual. Features include shared title words, journal name, coauthors, medical subject headings, language, affiliations, and author name features (middle initial, suffix, and prevalence in MEDLINE). Here we test the hypothesis that the Author-ity model will suffice to disambiguate author names for the vast majority of articles in MEDLINE. Methods Enhancements include: (a) incorporating first names and their variants, email addresses, and correlations between specific last names and affiliation words; (b) new methods of generating large unbiased training sets; (c) new methods for estimating the prior probability; (d) a weighted least squares algorithm for correcting transitivity violations; and (e) a maximum likelihood based agglomerative algorithm for computing clusters of articles that represent inferred author-individuals. Results Pairwise comparisons were computed for all author names on all 15.3 million articles in MEDLINE (2006 baseline), that share last name and first initial, to create Author-ity 2006, a database that has each name on each article assigned to one of 6.7 million inferred author-individual clusters. Recall is estimated at ~98.8%. Lumping (putting two different individuals into the same cluster) affects ~0.5% of clusters, whereas splitting (assigning articles written by the same individual to >1 cluster) affects ~2% of articles. Impact The Author-ity model can be applied generally to other bibliographic databases. Author name disambiguation allows information retrieval and data integration to become person-centered, not just document-centered, setting the stage for new data mining and social network tools that will facilitate the analysis of scholarly publishing and collaboration behavior. Availability The Author-ity 2006 database is available for nonprofit academic research, and can be freely queried via http://arrowsmith.psych.uic.edu. PMID:20072710

  7. Complex event extraction at PubMed scale

    PubMed Central

    Björne, Jari; Ginter, Filip; Pyysalo, Sampo; Tsujii, Jun'ichi; Salakoski, Tapio

    2010-01-01

    Motivation: There has recently been a notable shift in biomedical information extraction (IE) from relation models toward the more expressive event model, facilitated by the maturation of basic tools for biomedical text analysis and the availability of manually annotated resources. The event model allows detailed representation of complex natural language statements and can support a number of advanced text mining applications ranging from semantic search to pathway extraction. A recent collaborative evaluation demonstrated the potential of event extraction systems, yet there have so far been no studies of the generalization ability of the systems nor the feasibility of large-scale extraction. Results: This study considers event-based IE at PubMed scale. We introduce a system combining publicly available, state-of-the-art methods for domain parsing, named entity recognition and event extraction, and test the system on a representative 1% sample of all PubMed citations. We present the first evaluation of the generalization performance of event extraction systems to this scale and show that despite its computational complexity, event extraction from the entire PubMed is feasible. We further illustrate the value of the extraction approach through a number of analyses of the extracted information. Availability: The event detection system and extracted data are open source licensed and available at http://bionlp.utu.fi/. Contact: jari.bjorne@utu.fi PMID:20529932

  8. COMMENTARY Open Access Cochrane methods -twenty years experience in

    E-print Network

    Paris-Sud XI, Université de

    COMMENTARY Open Access Cochrane methods - twenty years experience in developing systematic review randomized trials, to answer questions about the effects of healthcare interventions. We introduce a series for improvement and development as pressures continue for the synthesis of the proliferation of re- search

  9. Parenting Training for Intellectually Disabled Parents: A Cochrane Systematic Review

    ERIC Educational Resources Information Center

    Coren, Esther; Thomae, Manuela; Hutchfield, Jemeela

    2011-01-01

    Objectives: This article presents a Cochrane/Campbell systematic review of the evidence on the effect of parent training to support the parenting of parents with intellectual disabilities. Method: Randomized controlled trials (RCTs) comparing parent training interventions for parents with intellectual disability with usual care or with a control…

  10. Avoidable Ignorance and the Role of Cochrane and Campbell Reviews

    ERIC Educational Resources Information Center

    Gambrill, Eileen

    2015-01-01

    The Campbell and Cochrane Collaborations were created to reveal the evidentiary status of claims focusing especially on the effectiveness of specific interventions. Such reviews are constrained by the population of studies available and biases that may influence this availability such as preferred framing of problems. This highlights the…

  11. PubMed redesign november 2009. PubMed van de National Library of Medicine (VS) is een zoeksysteem voor biomedische literatuur.

    E-print Network

    Franssen, Michael

    , en naar andere NLM databases Links naar andere NLM zoeksystemen zoals ClinicalTrials.gov®, MedlinePlus zoektermen met de MeSH (Medical Subject Heading Database), een gids naar MEDLINE's gecontroleerde

  12. Assessing and presenting summaries of evidence in Cochrane Reviews

    PubMed Central

    2013-01-01

    Cochrane Reviews are intended to help providers, practitioners and patients make informed decisions about health care. The goal of the Cochrane Applicability and Recommendation Methods Group (ARMG) is to develop approaches, strategies and guidance that facilitate the uptake of information from Cochrane Reviews and their use by a wide audience with specific focus on developers of recommendations and on healthcare decision makers. This paper is part of a series highlighting developments in systematic review methodology in the 20 years since the establishment of The Cochrane Collaboration, and its aim is to present current work and highlight future developments in assessing and presenting summaries of evidence, with special focus on Summary of Findings (SoF) tables and Plain Language Summaries. A SoF table provides a concise and transparent summary of the key findings of a review in a tabular format. Several studies have shown that SoF tables improve accessibility and understanding of Cochrane Reviews. The ARMG and GRADE Working Group are working on further development of the SoF tables, for example by evaluating the degree of acceptable flexibility beyond standard presentation of SoF tables, developing SoF tables for diagnostic test accuracy reviews and interactive SoF tables (iSoF). The plain language summary (PLS) is the other main building block for dissemination of review results to end-users. The PLS aims to summarize the results of a review in such a way that health care consumers can readily understand them. Current efforts include the development of a standardized language to describe statistical results, based on effect size and quality of supporting evidence. Producing high quality PLS and SoF tables and making them compatible and linked would make it easier to produce dissemination products targeting different audiences (for example, providers, health policy makers, guideline developers). Current issues of debate include optimal presentation formats of SoF tables, the training required to produce SoF tables, and the extent to which the authors of Cochrane Reviews should provide explicit guidance to target audiences of patients, clinicians and policy-makers. PMID:24059250

  13. Some problems with Cochrane reviews of diet and chronic disease

    Microsoft Academic Search

    A S Truswell

    2005-01-01

    The sum of evidence-based nutrition has to be more than a Cochrane-type meta-analysis of randomised controlled trials (RCTs). Most of the evidence base in nutrition is observational, especially cohort studies. RCTs of diet change through to disease outcome are uncommon and the change has usually been addition or removal of only a single food component. Trials with whole diets through

  14. Mobile app versus Web app: a comparison using 2008-2012 "PubMed for Handhelds" server data.

    PubMed

    Fontelo, Paul; Liu, Fang

    2013-01-01

    Recent surveys show that mobile apps are more popular than Web apps. Apple's iTunes Store, now has about 800,000 apps and reported to have about 40 billion downloads. Android apps, although fewer, is available to the most number of smartphones today. About 40,000 apps are medical or health related. We developed a PubMed4Hh mobile app for iPhone/iPad users to search MEDLINE/PubMed with same features as our Web-based search tools, in use since 2002. Five-year (2008-2012) server data for PubMed4Hh and Web app were analyzed. Searches using the mobile app significantly increased compared to the same five-year time period. Month-by-month comparison showed a 3 to 5-fold increase in queries. The six-month total accesses comparison increased 280% from the previous four-year average. A review of 500 randomly selected queries revealed that the majority of queries were clinical questions ((97.8%) and 61% of these queries are searches related to therapy. PMID:24551349

  15. MedlinePlus FAQ: What's New on Medline Plus Page and Email Updates

    MedlinePLUS

    ... Cool Tools ESPAÑOL Question: How is the What's New on MedlinePlus page and RSS feed different from ... this page, please enable JavaScript. Answer: The What's New on MedlinePlus page and RSS feed include alerts ...

  16. Visit the new MedlinePlus | NIH MedlinePlus the Magazine

    MedlinePLUS

    ... this page please turn Javascript on. Visit the new MedlinePlus Past Issues / Fall 2010 Table of Contents ... trusted, up-to-date medical information Visit the new MedlinePlus From the top medical experts at the ...

  17. MedlinePlus FAQ: Can you tell me how to cite MedlinePlus pages?

    MedlinePLUS

    ... date you saw the information online. Homepage MedlinePlus [Internet]. Bethesda (MD): National Library of Medicine (US); [updated ... add information about the topic being cited : MedlinePlus [Internet]. Bethesda (MD): National Library of Medicine (US); [updated ...

  18. MedlinePlus Survey Results 2012

    MedlinePLUS

    ... in 2012. Learn more about the American Customer Satisfaction Index survey used to gather MedlinePlus survey data. During 2012 MedlinePlus served an average of 62 million page views a month. Patients, their families, and their health care providers come ...

  19. MedlinePlus Connect: Web Application

    MedlinePLUS

    MedlinePlus Connect: Web Application To use the sharing features on this page, please enable JavaScript. MedlinePlus Connect is available as a ... please see our guidelines and instructions on linking. Web Application Overview The API for the Web application ...

  20. School as Parkland: Re-Storying the Story of Cochrane School

    ERIC Educational Resources Information Center

    Craig, Cheryl J.

    2007-01-01

    The narrative inquiry reported in this study offers a partial view of Cochrane Academy's nuanced landscape. This article elaborates a theoretical frame, then uses different story perspectives to survey Cochrane's professional knowledge landscape over time. It relates what currently is Cochrane Academy to parkland landscape, and it discusses the…

  1. Development of biomedical publications on ametropia research in PubMed from 1845 to 2010: a bibliometric analysis

    PubMed Central

    Xu, Chang-Tai; Li, Shan-Qu; Lü, Yong-Gang; Pan, Bo-Rong

    2011-01-01

    AIM We have carried out a bibliometric analysis on the development of ametropia literature to determine its growth rule and tendency, and to provide the basis for the problems related to ametropia research. METHODS Literatures that contained the descriptors of ametropia in title or paper published before Nov. 10, 2010 in PubMed databases (www.ncbi.nlm.nih.gov/Pubmed) were selected. As bibliometric indicators of ametropia, biomedical journals referring to ophthalmology by ISSN were calculated. The principal bibliometric indicators: Price's and Bradford's laws were applied on the increase or dispersion of scientific literature, the participation index of languages and the journals. By means of manual coding, literatures were classified according to documents study and statistical analysis. RESULTS The literatures cited in ametropia, astigmatism, myopia and hypermetropia had accumulated to 26475, which consists of Review (n=1560), Randomized Controlled Trial (n=776), Practice Guideline (n=10), Meta-Analysis (n=23), Letter (n=1222), Editorial (n=328), Clinical Trial (n=1726) and Others (n=20830), and Humans (n=23073), Animals(n=1434) and others (n=1968). 1136 literatures were included in PubMed Central, 22384 in MEDLINE and 2955 in others. The ametropia literatures rose every 5 years which of the ametropia-year cumulated amount of the literatures had three periods: before 1900, slowly increasing from 1901 to 1950, rapidly rising from 1951 to 2010 (increased approximate exponentiation exponent). Sixty kinds of languages listed in PubMed databases, of which English is dominant for aborting to ametropia research documents before 2010 (77.32%, 20471/26475). The document languages of top eight account for 95.58% (English, German, French, Japanese, Russian, Italian, Spanish, Chinese), and others for 4.42% (1171/26475). The SCI database includes 48 ophthalmologic journals and the impact factor of 39 journals is ?1 on Thomson-Reuters in 2010. Of 48 ophthalmologic journals, there were 14785 documents (55.85%) of ametropia, astigmatism, myopia, and hypermetropia. Others were without exception. CONCLUSION The bibliometric analysis results show that ametropia literature are increased progressively, approximate exponentiation exponent during 1951-2010. In addition, ametropia research has become more popular since nearly half century. PMID:22553598

  2. Psychosocial interventions to reduce alcohol consumption in concurrent problem alcohol and illicit drug users: Cochrane Reviewa

    PubMed Central

    2013-01-01

    Background Problem alcohol use is common among illicit drug users and is associated with adverse health outcomes. It is also an important factor in poor prognosis among drug users with hepatitis C virus (HCV) as it impacts progression to hepatic cirrhosis or opiate overdose in opioid users. The aim of this systematic review was to assess the effects of psychosocial interventions for problem alcohol use in adult illicit drug users with concurrent problem alcohol use (principally, problem drug users of opiates and stimulants). Methods We searched the following databases (November 2011): Cochrane Library, PUBMED, EMBASE, CINAHL, PsycINFO and reference list of articles. We also searched conference proceedings and online registers of clinical trials. Two reviewers independently assessed risk of bias and extracted data from included randomized controlled trials. Results Four studies (594 participants) were included in this review. Half of the trials were rated as having a high or unclear risk of bias. The four studies considered six different psychosocial interventions grouped into four comparisons: 1) cognitive-behavioral coping skills training versus 12-step facilitation (N = 41), 2) brief intervention versus treatment as usual (N = 110), 3) hepatitis health promotion versus motivational interviewing (N = 256), and 4) brief motivational intervention versus assessment-only group (N = 187). Differences between studies precluded any pooling of data. Findings are described for each trial individually. Most findings were not statistically significant except for comparison 2: decreased alcohol use at three months (risk ratio (RR) 0.32; 95% confidence interval (CI) 0.19 to 0.54) and nine months (RR 0.16; 95% CI 0.08 to 0.33) in the treatment-as-usual group and comparison 4: reduced alcohol use in the brief motivational intervention (RR 1.67; 95% CI 1.08 to 2.60). Conclusions No conclusion can be made because of the paucity of the data and the low quality of the retrieved studies. PMID:23311684

  3. Selenium Supplementation for Hashimoto's Thyroiditis: Summary of a Cochrane Systematic Review

    PubMed Central

    van Zuuren, Esther J.; Albusta, Amira Y.; Fedorowicz, Zbys; Carter, Ben; Pijl, Hanno

    2014-01-01

    Selenium supplementation in people with Hashimoto's thyroiditis might reduce antibody levels and result in a decreased dosage of levothyroxine (LT4) and may provide other beneficial effects (e.g. on mood and health-related quality of life). The aim of our systematic review was to assess the effects of selenium supplementation on Hashimoto's thyroiditis. We searched The Cochrane Library, MEDLINE, EMBASE and Web of Science for randomized controlled trials. Study selection, data extraction, assessment of risk of bias and analyses were carried out by two independent review authors. We assessed the quality of the evidence of included studies using GRADE. Four studies rated at unclear to high risk of bias comprising 463 participants were included. One study at high risk of bias showed statistically significant improvement in subjective well-being with sodium selenite 200 ?g plus titrated LT4 compared with placebo plus titrated LT4 (RR 4.67, 95% CI 1.61-13.50). Selenomethionine 200 ?g as a single treatment or combined with LT4 reduced the serum levels of anti-thyroid peroxidase antibodies compared with placebo (or placebo plus LT4) in three studies (p < 0.001). Although the changes from baseline were statistically significant in these three studies, their clinical relevance is unclear. In conclusion, the results of these four studies, assessed at unclear to high risk of bias, show that evidence to support or refute the efficacy of selenium supplementation in people with Hashimoto's thyroiditis is incomplete and not reliable to help inform clinical decision making. PMID:24847462

  4. Selenium Supplementation for Hashimoto's Thyroiditis: Summary of a Cochrane Systematic Review.

    PubMed

    van Zuuren, Esther J; Albusta, Amira Y; Fedorowicz, Zbys; Carter, Ben; Pijl, Hanno

    2014-03-01

    Selenium supplementation in people with Hashimoto's thyroiditis might reduce antibody levels and result in a decreased dosage of levothyroxine (LT4) and may provide other beneficial effects (e.g. on mood and health-related quality of life). The aim of our systematic review was to assess the effects of selenium supplementation on Hashimoto's thyroiditis. We searched The Cochrane Library, MEDLINE, EMBASE and Web of Science for randomized controlled trials. Study selection, data extraction, assessment of risk of bias and analyses were carried out by two independent review authors. We assessed the quality of the evidence of included studies using GRADE. Four studies rated at unclear to high risk of bias comprising 463 participants were included. One study at high risk of bias showed statistically significant improvement in subjective well-being with sodium selenite 200 ?g plus titrated LT4 compared with placebo plus titrated LT4 (RR 4.67, 95% CI 1.61-13.50). Selenomethionine 200 ?g as a single treatment or combined with LT4 reduced the serum levels of anti-thyroid peroxidase antibodies compared with placebo (or placebo plus LT4) in three studies (p < 0.001). Although the changes from baseline were statistically significant in these three studies, their clinical relevance is unclear. In conclusion, the results of these four studies, assessed at unclear to high risk of bias, show that evidence to support or refute the efficacy of selenium supplementation in people with Hashimoto's thyroiditis is incomplete and not reliable to help inform clinical decision making. PMID:24847462

  5. NLM Director's Comments Podcasts: MedlinePlus

    MedlinePLUS

    ... Director's Comments on . Clicking on this link opens iTunes and takes you to the MedlinePlus: NLM Director's ... the most recent podcast should download automatically. An iTunes subscription to NLM Director's comments works only if ...

  6. Connecting the Dots between PubMed Abstracts

    PubMed Central

    Hossain, M. Shahriar; Gresock, Joseph; Edmonds, Yvette; Helm, Richard; Potts, Malcolm; Ramakrishnan, Naren

    2012-01-01

    Background There are now a multitude of articles published in a diversity of journals providing information about genes, proteins, pathways, and diseases. Each article investigates subsets of a biological process, but to gain insight into the functioning of a system as a whole, we must integrate information from multiple publications. Particularly, unraveling relationships between extra-cellular inputs and downstream molecular response mechanisms requires integrating conclusions from diverse publications. Methodology We present an automated approach to biological knowledge discovery from PubMed abstracts, suitable for “connecting the dots” across the literature. We describe a storytelling algorithm that, given a start and end publication, typically with little or no overlap in content, identifies a chain of intermediate publications from one to the other, such that neighboring publications have significant content similarity. The quality of discovered stories is measured using local criteria such as the size of supporting neighborhoods for each link and the strength of individual links connecting publications, as well as global metrics of dispersion. To ensure that the story stays coherent as it meanders from one publication to another, we demonstrate the design of novel coherence and overlap filters for use as post-processing steps. Conclusions We demonstrate the application of our storytelling algorithm to three case studies: i) a many-one study exploring relationships between multiple cellular inputs and a molecule responsible for cell-fate decisions, ii) a many-many study exploring the relationships between multiple cytokines and multiple downstream transcription factors, and iii) a one-to-one study to showcase the ability to recover a cancer related association, viz. the Warburg effect, from past literature. The storytelling pipeline helps narrow down a scientist's focus from several hundreds of thousands of relevant documents to only around a hundred stories. We argue that our approach can serve as a valuable discovery aid for hypothesis generation and connection exploration in large unstructured biological knowledge bases. PMID:22235301

  7. Overview of Reviews The prevention of eczema in infants and children: an overview of Cochrane and non-Cochrane reviews

    PubMed Central

    Foisy, Michelle; Boyle, Robert J.; Chalmers, Joanne R.; Simpson, Eric L.; Williams, Hywel C.

    2012-01-01

    Background Eczema is the most common inflammatory skin disease of childhood, characterized by an itchy red rash that usually involves the face and skin folds. There is currently no curative treatment for eczema, so the reduction of eczema incidence through disease prevention is a desirable goal. Potential interventions for preventing eczema include exclusive breastfeeding, hydrolysed protein formulas and soy formulas when bottle feeding, maternal antigen avoidance, omega oil supplementation, prebiotics and probiotics. Objectives This overview of reviews aims to present the current body of data from Cochrane and non-Cochrane reviews to provide the most up-to-date evidence on the efficacy and safety of interventions to prevent eczema in infants and children at different risk levels for developing allergic disease. Methods Our pool of Cochrane and non-Cochrane reviews came from the 2010 United Kingdom National Health Service (NHS) Evidence Skin Disorders Annual Evidence Updates Mapping Exercise on Atopic Eczema. This group used a comprehensive search strategy last conducted in August 2010 to identify all systematic reviews on eczema prevention. We identified all reviews that met our pre-specified inclusion criteria, and data were extracted, analysed, compiled into tables and synthesized using quantitative and qualitative methods. Main results Seven systematic reviews containing 39 relevant trials with 11 897 participants were included in this overview. Overall, there was no clear evidence that any of the main interventions reviewed reduced eczema incidence. In subgroup analyses of infants at high risk of allergic disease, an observational study found that exclusive breastfeeding for at least six months compared with introduction of solids at three to six months decreased the incidence of eczema by 60% (risk ratio (RR): 0.40; 95% confidence interval (CI): 0.21, 0.78), and a randomized controlled trial found that prebiotics compared with no prebiotics decreased incidence by 58% (RR: 0.42; 95% CI: 0.21, 0.84). However, each of these findings was based on the results of a single small trial, and no intervention reduced eczema incidence beyond the first two years of life. Although we pre-specified incidence of atopic eczema (i.e. eczema associated with immunoglobulin E (IgE) sensitization) as a primary outcome, data on whether participants diagnosed with eczema were truly atopic were largely lacking from systematic reviews. Similarly, data on atopy, measured using skin prick tests or specific IgE tests to allergens, were not reported in many reviews. No interventions were found to decrease atopy when reported. Adverse events data were generally lacking, but data from a trial of probiotics versus no probiotics showed significantly more spitting up in the first one (RR: 1.88; 95% CI: 1.03, 3.45) and two (RR: 1.69; 95% CI: 1.02, 2.80) months of life, but no overall increase in risk of gastrointestinal symptoms in the first year. Authors’ conclusions Although there is currently no clear evidence showing that any of the interventions examined in this overview prevent eczema in participants not selected for risk of allergic disease, there is some evidence that exclusive breastfeeding for at least six months and prebiotics might reduce eczema incidence in high-risk participants. However, these conclusions are based on limited evidence with methodological shortcomings. Future research on prevention of eczema is needed and should examine different types of hydrolysed formulas, prebiotics and probiotics, as well as enhancement of the skin barrier and other novel approaches in infants at different risk levels for developing allergic disease. PMID:22822349

  8. An active visual search interface for Medline.

    PubMed

    Xuan, Weijian; Dai, Manhong; Mirel, Barbara; Wilson, Justin; Athey, Brian; Watson, Stanley J; Meng, Fan

    2007-01-01

    Searching the Medline database is almost a daily necessity for many biomedical researchers. However, available Medline search solutions are mainly designed for the quick retrieval of a small set of most relevant documents. Because of this search model, they are not suitable for the large-scale exploration of literature and the underlying biomedical conceptual relationships, which are common tasks in the age of high throughput experimental data analysis and cross-discipline research. We try to develop a new Medline exploration approach by incorporating interactive visualization together with powerful grouping, summary, sorting and active external content retrieval functions. Our solution, PubViz, is based on the FLEX platform designed for interactive web applications and its prototype is publicly available at: http://brainarray.mbni.med.umich.edu/Brainarray/DataMining/PubViz. PMID:17951838

  9. Identifying the fundamentals of care within Cochrane Systematic reviews: the role of the Cochrane Nursing Care Field Fundamentals of Care Node.

    PubMed

    Kitson, Alison; Robertson-Malt, Suzi; Conroy, Tiffany

    2013-04-01

    The role of the Fundamentals of Care (FoC) Node within the Cochrane Nursing Care Field (CNCF) is to identify universal aspects of patient care as they relate to and potentially affect the application of the results of systematic reviews. The CNCF was established to provide a nursing perspective of Cochrane reviews and to promote their dissemination and uptake. The core functions of the CNCF include identifying topics for nursing care not currently addressed by Cochrane Reviews, raising awareness of the Cochrane Collaboration and the resources it has that supports the delivery of nursing care and the dissemination of relevant reviews to the nursing care community. We outline how volunteers with an interest in the FoC can work to identify care-related aspects for specific clinical reviews. This article describes the development of a tool designed to guide the review of a Cochrane Systematic Review from the vantage of the FoC. The FoC Node is seeking volunteers to undertake this review work, and we have outlined the steps used to do this. We also show how using the FoC Template can inform the tagging and classifying of existing reviews within the Cochrane library. PMID:23577967

  10. Reconsidering the Teacher Education Reform Debate: A Commentary on Cochran-Smith and Fries

    Microsoft Academic Search

    Gary D Fenstermacher

    2002-01-01

    In the November 2001 issue of Educational Researcher, Marilyn Cochran-Smith and Mary Kim Fries provided a penetrating analysis of the discourse that comprises the debate between those who advocate highly professionalized teacher preparation and those who seek simpler and more abundant routes to teacher training and certification. This commentary extends the Cochran-Smith and Fries analysis in several directions, inquiring into

  11. Economics methods in Cochrane systematic reviews of health promotion and public health related interventions

    Microsoft Academic Search

    Ian Shemilt; Miranda Mugford; Michael Drummond; Eric Eisenstein; Jacqueline Mallender; David McDaid; Luke Vale; Damian Walker

    2006-01-01

    BACKGROUND: Provision of evidence on costs alongside evidence on the effects of interventions can enhance the relevance of systematic reviews to decision-making. However, patterns of use of economics methods alongside systematic review remain unclear. Reviews of evidence on the effects of interventions are published by both the Cochrane and Campbell Collaborations. Although it is not a requirement that Cochrane or

  12. Herbal Medicine - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... features on this page, please enable JavaScript. Herbal Medicine - Multiple Languages Chinese - Simplified (????) French (français) Hindi (??????) ... Return to the MedlinePlus Health Information in Multiple Languages page. ... Library of Medicine 8600 Rockville Pike, Bethesda, MD 20894 U.S. Department ...

  13. Detroit MEDLINE Consortium; An Interim Report.

    ERIC Educational Resources Information Center

    DeSchryver, Victor; And Others

    The Detroit MEDLINE Consortium is an experimental pilot project which is intended to extend use of the on line retrieval system to the hospital environment. The consortium was initiated to increase the capacity for bibliographic information retrieval supportive of the delivery of patient care in the hospital environment. Secondarily, it addresses…

  14. Development and classification of an operational definition of complementary and alternative medicine for the Cochrane Collaboration

    PubMed Central

    Wieland, L. Susan; Manheimer, Eric; Berman, Brian M.

    2011-01-01

    Over the past decade the Cochrane Collaboration has been an increasingly important source of information on complementary and alternative medicine (CAM) therapies. From 2007 to 2008 the Cochrane CAM Field developed a topics list that allowed us to categorize all 396 Cochrane reviews related to CAM (as of The Cochrane Library, Issue 4, 2009). This topics list is an advance in making Cochrane reviews on CAM topics accessible to the public. In this paper, we discuss challenges in developing the topics list, including developing an operational definition of CAM, deciding which reviews should be included within the CAM Field’s scope, developing the structured list of CAM Field-specific topics, and determining where in the topics list the reviews should be placed. Although aspects of our operational definition of CAM are open to revision, a standardized definition provides us with an objective, reproducible and systematic method for defining and classifying CAM therapies. PMID:21717826

  15. Research synthesis and dissemination as a bridge to knowledge management: the Cochrane Collaboration.

    PubMed Central

    Volmink, Jimmy; Siegfried, Nandi; Robertson, Katharine; Gülmezoglu, A. Metin

    2004-01-01

    In the current information age, research synthesis is a particularly useful tool for keeping track of scientific research and making sense of the large volumes of frequently conflicting data derived from primary studies. The Cochrane Collaboration is a global initiative "to help people make well-informed decisions about health care by preparing, maintaining and promoting the accessibility of systematic reviews of the effects of healthcare interventions". In this paper we set the work of the Cochrane Collaboration in historical perspective, explain what a Cochrane review is, and describe initiatives for promoting worldwide dissemination of synthesized information. We also consider emerging evidence of the Cochrane Collaboration's impact on health-care practice, policy, research and education. Finally, we highlight the need for increased investment in the preparation and maintenance of Cochrane reviews, particularly those that address health issues that are relevant to people living in low- and middle-income countries. PMID:15643800

  16. Do Cochrane reviews provide useful information to guide policy and practice? The experience of the Cochrane drugs and alcohol group.

    PubMed

    Davoli, M; Amato, L

    2011-09-01

    This contribution reviewed the experience of the Cochrane Drugs and Alcohol Group (CDAG) in terms of production of evidence to guide policy and practice. By December 2010, the group had published 55 reviews, with 299 authors involved and 744 primary studies included out of 2114 studies considered for inclusion. 90% of the studies included were randomized controlled trials (RCTs). Considering the 'Implication for practice' section of each review, 31% interventions were classified as to do, 11% as do not do it, 52% to do only in research and for 6% a final judgment was impossible because the reviews included no studies or only one study. These proportions varied according to the type of substance of abuse studied; interventions judged as to do were 42% for alcohol, 32% for opioids, 12% for psychostimulants, 33% for poly drugs, and for prevention. The reviews produced by the CDAG provide evidence on effectiveness of several interventions, and identify areas of uncertainty, where more primary research is needed. PMID:21922962

  17. Multidisciplinary biopsychosocial rehabilitation for chronic low back pain: Cochrane systematic review and meta-analysis

    PubMed Central

    Apeldoorn, A T; Chiarotto, A; Smeets, R J E M; Ostelo, R W J G; Guzman, J; van Tulder, M W

    2015-01-01

    Objective To assess the long term effects of multidisciplinary biopsychosocial rehabilitation for patients with chronic low back pain. Design Systematic review and random effects meta-analysis of randomised controlled trials. Data sources Electronic searches of Cochrane Back Review Group Trials Register, CENTRAL, Medline, Embase, PsycINFO, and CINAHL databases up to February 2014, supplemented by hand searching of reference lists and forward citation tracking of included trials. Study selection criteria Trials published in full; participants with low back pain for more than three months; multidisciplinary rehabilitation involved a physical component and one or both of a psychological component or a social or work targeted component; multidisciplinary rehabilitation was delivered by healthcare professionals from at least two different professional backgrounds; multidisciplinary rehabilitation was compared with a non- multidisciplinary intervention. Results Forty one trials included a total of 6858 participants with a mean duration of pain of more than one year who often had failed previous treatment. Sixteen trials provided moderate quality evidence that multidisciplinary rehabilitation decreased pain (standardised mean difference 0.21, 95% confidence interval 0.04 to 0.37; equivalent to 0.5 points in a 10 point pain scale) and disability (0.23, 0.06 to 0.40; equivalent to 1.5 points in a 24 point Roland-Morris index) compared with usual care. Nineteen trials provided low quality evidence that multidisciplinary rehabilitation decreased pain (standardised mean difference 0.51, ?0.01 to 1.04) and disability (0.68, 0.16 to 1.19) compared with physical treatments, but significant statistical heterogeneity across trials was present. Eight trials provided moderate quality evidence that multidisciplinary rehabilitation improves the odds of being at work one year after intervention (odds ratio 1.87, 95% confidence interval 1.39 to 2.53) compared with physical treatments. Seven trials provided moderate quality evidence that multidisciplinary rehabilitation does not improve the odds of being at work (odds ratio 1.04, 0.73 to 1.47) compared with usual care. Two trials that compared multidisciplinary rehabilitation with surgery found little difference in outcomes and an increased risk of adverse events with surgery. Conclusions Multidisciplinary biopsychosocial rehabilitation interventions were more effective than usual care (moderate quality evidence) and physical treatments (low quality evidence) in decreasing pain and disability in people with chronic low back pain. For work outcomes, multidisciplinary rehabilitation seems to be more effective than physical treatment but not more effective than usual care. PMID:25694111

  18. How to improve your PubMed/MEDLINE searches: 3. advanced searching, MeSH and My NCBI.

    PubMed

    Fatehi, Farhad; Gray, Leonard C; Wootton, Richard

    2014-03-01

    Although the basic PubMed search is often helpful, the results may sometimes be non-specific. For more control over the search process you can use the Advanced Search Builder interface. This allows a targeted search in specific fields, with the convenience of being able to select the intended search field from a list. It also provides a history of your previous searches. The search history is useful to develop a complex search query by combining several previous searches using Boolean operators. For indexing the articles in MEDLINE, the NLM uses a controlled vocabulary system called MeSH. This standardised vocabulary solves the problem of authors, researchers and librarians who may use different terms for the same concept. To be efficient in a PubMed search, you should start by identifying the most appropriate MeSH terms and use them in your search where possible. My NCBI is a personal workspace facility available through PubMed and makes it possible to customise the PubMed interface. It provides various capabilities that can enhance your search performance. PMID:24614997

  19. Rev Epidemiol Sante Publique . Author manuscript Fanny Bourr e

    E-print Network

    Paris-Sud XI, Université de

    was performed in Pubmed/MEDLINE, Banque de Donn es Sant Publique (BDSP), The Cochrane Library, Pascal sont le plus souvent utilis es pour prendre des d cisions, g n rer des id es ou hi rarchiser, dans des

  20. PubMed QUICK GUIDE University of California Berkeley Library Use this URL to access the UCcustomized version of PubMed, with links to UCBsubscribed full text

    E-print Network

    PubMed searching is easy: just enter terms in the search box and click Search. The Advanced Search link below the search box provides access to additional searching options. Keyword Searching Enter combines (ANDs) significant terms together using automatic term mapping, matching your search terms

  1. MedlinePlus FAQ: Listing Your Web Site

    MedlinePLUS

    ... Supplements Videos & Cool Tools ESPAÑOL Question: How do Web sites get listed in MedlinePlus? To use the ... authoritative resources. MedlinePlus uses quality guidelines to evaluate Web sites. We try to ensure that the information ...

  2. MedlinePlus FAQ: Easy-to-Read Documents

    MedlinePLUS

    ... Cool Tools ESPAÑOL Question: How can I locate materials on MedlinePlus that are easy to read and ... public, not for health professionals. But, not all materials on MedlinePlus are at the same reading level. ...

  3. MedlinePlus FAQ: Copyrighted and Non-Copyrighted Material

    MedlinePLUS

    ... Supplements Videos & Cool Tools ESPAÑOL Question: Is the material on MedlinePlus copyrighted? To use the sharing features ... Answer: MedlinePlus contains both copyrighted and non-copyrighted material. Please see our copyright information page . Restrictions may ...

  4. MedlinePlus Marks its 15th Anniversary

    MedlinePLUS

    ... or near the top of the American Customer Satisfaction Index for government news sites. In 2010, MedlinePlus introduced the MedlinePlus Connect service that allows electronic health record systems to link from patient diagnoses, medications, and lab test results to MedlinePlus ...

  5. GOClonto: an ontological clustering approach for conceptualizing PubMed abstracts.

    PubMed

    Zheng, Hai-Tao; Borchert, Charles; Kim, Hong-Gee

    2010-02-01

    Concurrent with progress in biomedical sciences, an overwhelming of textual knowledge is accumulating in the biomedical literature. PubMed is the most comprehensive database collecting and managing biomedical literature. To help researchers easily understand collections of PubMed abstracts, numerous clustering methods have been proposed to group similar abstracts based on their shared features. However, most of these methods do not explore the semantic relationships among groupings of documents, which could help better illuminate the groupings of PubMed abstracts. To address this issue, we proposed an ontological clustering method called GOClonto for conceptualizing PubMed abstracts. GOClonto uses latent semantic analysis (LSA) and gene ontology (GO) to identify key gene-related concepts and their relationships as well as allocate PubMed abstracts based on these key gene-related concepts. Based on two PubMed abstract collections, the experimental results show that GOClonto is able to identify key gene-related concepts and outperforms the STC (suffix tree clustering) algorithm, the Lingo algorithm, the Fuzzy Ants algorithm, and the clustering based TRS (tolerance rough set) algorithm. Moreover, the two ontologies generated by GOClonto show significant informative conceptual structures. PMID:19635585

  6. Challenges and strategies of increasing the production and use of Cochrane reviews: the Argentinean experience.

    PubMed

    Ciapponi, Agustín

    2008-01-01

    The Cochrane Collaboration (CC), established in 1993, is an internationally renowned initiative dedicated to improving health care for the world's population. In the late 1990 s, the Iberoamerican Cochrane Centre (IbCC) was created to promote the CC in Latin America. Because the production and use of Cochrane reviews were still low in 2002, Argentina implemented specific strategies and a model to expand the IbCC. The objective of this article was to describe strategies to increase the production and use of Cochrane reviews in Argentina. Methods used included surveys delivered to primary health care workers to provide data about their knowledge and use of the CC, and about the production of titles, protocols, and systematic reviews published in the Cochrane Library. Our survey showed that only 51% of a selected population of primary healthcare workers knew about the CC and only 23% knew about the Argentine Cochrane centre. In the previous year, 60% had never used the CC. To overcome these challenges, we used seven types of complementary strategies: (1) networking, (2) dissemination, (3) training, (4) support to Cochrane members, (5) strategic alliances, (6) research, and (7) fund-raising. An improvement in the production and use of Cochrane reviews was seen in Argentina, and the set of aforementioned strategies could be partly responsible for this increase. Multi-level networking, training and an appropriate centre's mother institution could be the most important interventions. More research is needed to explore this hypothesis. Lessons learned on this first evaluation will help us to continue with the development of the CC in Argentina. PMID:18237346

  7. MedlinePLUS: Interactive Health Tutorials

    NSDL National Science Digital Library

    This Web site from the National Library of Medicine's MedlinePLUS contains interactive health tutorials developed by the Patient Education Institute. The tutorials use easy-to-follow animations and narration to explain medical procedures and health conditions. Dozens and dozens of tutorials are available. Recent additions include tutorials on smallpox, hearing loss, bone densitometry, dust mite allergies, and many more. Users control the pace of the tutorial, and can test their understanding of the material at various points with short, interactive quizzes.

  8. Finding UMLS Metathesaurus concepts in MEDLINE.

    PubMed Central

    Srinivasan, Suresh; Rindflesch, Thomas C.; Hole, William T.; Aronson, Alan R.; Mork, James G.

    2002-01-01

    The entire collection of 11.5 million MEDLINE abstracts was processed to extract 549 million noun phrases using a shallow syntactic parser. English language strings in the 2002 and 2001 releases of the UMLS Metathesaurus were then matched against these phrases using flexible matching techniques. 34% of the Metathesaurus names (occurring in 30% of the concepts) were found in the titles and abstracts of articles in the literature. The matching concepts are fairly evenly chemical and non-chemical in nature and span a wide spectrum of semantic types. This paper details the approach taken and the results of the analysis. PMID:12463920

  9. Strategies to improve retention in randomised trials: a Cochrane systematic review and meta-analysis

    PubMed Central

    Brueton, V C; Tierney, J F; Stenning, S; Meredith, S; Harding, S; Nazareth, I; Rait, G

    2014-01-01

    Objective To quantify the effect of strategies to improve retention in randomised trials. Design Systematic review and meta-analysis. Data sources Sources searched: MEDLINE, EMBASE, PsycINFO, DARE, CENTRAL, CINAHL, C2-SPECTR, ERIC, PreMEDLINE, Cochrane Methodology Register, Current Controlled Trials metaRegister, WHO trials platform, Society for Clinical Trials (SCT) conference proceedings and a survey of all UK clinical trial research units. Review methods Included trials were randomised evaluations of strategies to improve retention embedded within host randomised trials. The primary outcome was retention of trial participants. Data from trials were pooled using the fixed-effect model. Subgroup analyses were used to explore the heterogeneity and to determine whether there were any differences in effect by the type of strategy. Results 38 retention trials were identified. Six broad types of strategies were evaluated. Strategies that increased postal questionnaire responses were: adding, that is, giving a monetary incentive (RR 1.18; 95% CI 1.09 to 1.28) and higher valued incentives (RR 1.12; 95% CI 1.04 to 1.22). Offering a monetary incentive, that is, an incentive given on receipt of a completed questionnaire, also increased electronic questionnaire response (RR 1.25; 95% CI 1.14 to 1.38). The evidence for shorter questionnaires (RR 1.04; 95% CI 1.00 to 1.08) and questionnaires relevant to the disease/condition (RR 1.07; 95% CI 1.01 to 1.14) is less clear. On the basis of the results of single trials, the following strategies appeared effective at increasing questionnaire response: recorded delivery of questionnaires (RR 2.08; 95% CI 1.11 to 3.87); a ‘package’ of postal communication strategies (RR 1.43; 95% CI 1.22 to 1.67) and an open trial design (RR 1.37; 95% CI 1.16 to 1.63). There is no good evidence that the following strategies impact on trial response/retention: adding a non-monetary incentive (RR=1.00; 95% CI 0.98 to 1.02); offering a non-monetary incentive (RR=0.99; 95% CI 0.95 to 1.03); ‘enhanced’ letters (RR=1.01; 95% CI 0.97 to 1.05); monetary incentives compared with offering prize draw entry (RR=1.04; 95% CI 0.91 to 1.19); priority postal delivery (RR=1.02; 95% CI 0.95 to 1.09); behavioural motivational strategies (RR=1.08; 95% CI 0.93 to 1.24); additional reminders to participants (RR=1.03; 95% CI 0.99 to 1.06) and questionnaire question order (RR=1.00, 0.97 to 1.02). Also based on single trials, these strategies do not appear effective: a telephone survey compared with a monetary incentive plus questionnaire (RR=1.08; 95% CI 0.94 to 1.24); offering a charity donation (RR=1.02, 95% CI 0.78 to 1.32); sending sites reminders (RR=0.96; 95% CI 0.83 to 1.11); sending questionnaires early (RR=1.10; 95% CI 0.96 to 1.26); longer and clearer questionnaires (RR=1.01, 0.95 to 1.07) and participant case management by trial assistants (RR=1.00; 95% CI 0.97 to 1.04). Conclusions Most of the trials evaluated questionnaire response rather than ways to improve participants return to site for follow-up. Monetary incentives and offers of monetary incentives increase postal and electronic questionnaire response. Some strategies need further evaluation. Application of these results would depend on trial context and follow-up procedures. PMID:24496696

  10. A SNPshot of PubMed to associate genetic variants with drugs, diseases, and adverse reactions

    E-print Network

    Baral, Chitta

    A SNPshot of PubMed to associate genetic variants with drugs, diseases, and adverse reactions Jörg, drug efficacy, and drug responses between individuals and sub-populations. Wrong dosages of drugs can lead to severe adverse drug reac- tions in individuals whose drug metabolism drastically differs from

  11. Comparison of PubMed, Scopus, Web of Science, and Google Scholar: strengths and weaknesses

    Microsoft Academic Search

    Matthew E. Falagas; Eleni I. Pitsouni; George A. Malietzis; Georgios Pappas

    2007-01-01

    The evolution of the electronic age has led to the development of numerous medical databases on the World Wide Web, offering search facilities on a particular subject and the ability to perform citation analysis. We compared the content coverage and prac- tical utility of PubMed, Scopus, Web of Science, and Google Scholar. The official Web pages of the data- bases

  12. Systematic reviews published in the July 2014 issue of the Cochrane Library.

    PubMed

    Wiffen, Philip J

    2014-12-01

    The Cochrane Library of Systematic Reviews is published quarterly as a DVD and monthly online ( http://www.thecochranelibrary.com ). The July 2014 issue (3rd DVD for 2014) contains 6050 complete reviews, 2,359 protocols for reviews in production, and 31,000 short summaries of systematic reviews published in the general medical literature. In addition, there are citations of 789,000 randomized controlled trials, and 15,700 cited papers in the Cochrane Methodology Register. The Health Technology Assessment database contains some 14,000 citations. Ninety-six new reviews have been published in the previous 3 months of which five have potential relevance for practitioners in pain and palliative medicine. The impact factor of the Cochrane Library stands at 5.715. Readers are encouraged to access the full report for any articles of interest as only a brief commentary is provided. PMID:25338103

  13. Antenatal interventions to reduce preterm birth: an overview of Cochrane systematic reviews

    PubMed Central

    2014-01-01

    Background Several factors are associated with an increased risk of preterm birth (PTB); therefore, various interventions might have the potential to influence it. Due to the large number of interventions that address PTB, the objective of this overview is to summarise evidence from Cochrane reviews regarding the effects and safety of these different interventions. Methods We conducted a systematic literature search in the Cochrane Database of Systematic Reviews. Included reviews should be based on randomised controlled trials comparing antenatal non-pharmacological and pharmacological interventions that directly or indirectly address PTB with placebo/no treatment or routine care in pregnant women at less than 37 completed weeks of gestation without signs of threatened preterm labour. We considered PTB at less than 37 completed weeks of gestation as the primary outcome. Results We included 56 Cochrane systematic reviews. Three interventions increased PTB risk significantly. Twelve interventions led to a statistically significant lower incidence of PTBs. However, this reduction was mostly observed in defined at-risk subgroups of pregnant women. The remaining antenatal interventions failed to prove a significant effect on PTB?Cochrane reviews which intended to report on PTB?Cochrane systematic reviews. Few interventions have been demonstrated to be effective and a small number have been found to be harmful. For around half of the interventions evaluated, the Cochrane review concluded that there was insufficient evidence to provide sound recommendations for clinical practice. No RCT evidence is available for a number of potentially relevant interventions. PMID:24758148

  14. The impact of Cochrane Systematic Reviews: a mixed method evaluation of outputs from Cochrane Review Groups supported by the UK National Institute for Health Research

    PubMed Central

    2014-01-01

    Background There has been a growing emphasis on evidence-informed decision-making in health care. Systematic reviews, such as those produced by the Cochrane Collaboration, have been a key component of this movement. The UK National Institute for Health Research (NIHR) Systematic Review Programme currently supports 20 Cochrane Review Groups (CRGs). The aim of this study was to identify the impacts of Cochrane reviews published by NIHR-funded CRGs during the years 2007–2011. Methods We sent questionnaires to CRGs and review authors, interviewed guideline developers and used bibliometrics and documentary review to get an overview of CRG impact and to evaluate the impact of a sample of 60 Cochrane reviews. We used a framework with four categories (knowledge production, research targeting, informing policy development and impact on practice/services). Results A total of 1,502 new and updated reviews were produced by the 20 NIHR-funded CRGs between 2007 and 2011. The clearest impacts were on policy with a total of 483 systematic reviews cited in 247 sets of guidance: 62 were international, 175 national (87 from the UK) and 10 local. Review authors and CRGs provided some examples of impact on practice or services, for example, safer use of medication, the identification of new effective drugs or treatments and potential economic benefits through the reduction in the use of unproven or unnecessary procedures. However, such impacts are difficult to objectively document, and the majority of reviewers were unsure if their review had produced specific impacts. Qualitative data suggested that Cochrane reviews often play an instrumental role in informing guidance, although a poor fit with guideline scope or methods, reviews being out of date and a lack of communication between CRGs and guideline developers were barriers to their use. Conclusions Health and economic impacts of research are generally difficult to measure. We found that to be the case with this evaluation. Impacts on knowledge production and clinical guidance were easier to identify and substantiate than those on clinical practice. Questions remain about how we define and measure impact, and more work is needed to develop suitable methods for impact analysis. PMID:25348511

  15. PubMed search tips March 2013, Medical Library Nijmegen MeSH Search Medical Subject Headings

    E-print Network

    van Suijlekom, Walter

    PubMed search tips March 2013, Medical Library Nijmegen Search MeSH Search Medical Subject HeadingsSH is the National Library of Medicine's controlled vocabulary thesaurus. It consists of sets of terms naming with a MeSH term in PubMed you have 2 options: 1. Type the MeSH term in the PubMed search box adding [Me

  16. Reaching Beyond MEDLINE: A Beginner's Overview of Electronic Biomedical Resources

    Microsoft Academic Search

    Keith M. Pickett

    2008-01-01

    Information professionals in the health sciences have a fantastic, readily available resource to use for locating and accessing information: MEDLINE. Many times, however, sleuthing reference librarians or informationists may find themselves looking beyond MEDLINE in order to find needed information in the fast-paced world of health science librarianship, because it does not index all of the possibly helpful literature, including

  17. Surgical management of pelvic organ prolapse in women: a short version Cochrane review

    Microsoft Academic Search

    Christopher Maher; Kaven Baessler; Cathryn M. A. Glazener; Elizabeth J. Adams; Suzanne Hagen

    2008-01-01

    Pelvic organ prolapse may occur in up to 50% of parous women. A variety of urinary, bowel and sexual symptoms may be associated with prolapse. Objectives were to determine the effects of the many different surgeries in the management of pelvic organ prolapse. We searched the Cochrane Incontinence Group Specialised Trials Register (searched 3 May 2006) and reference lists of

  18. Assessing Diagnostic Expertise of Counselors Using the Cochran-Weiss-Shanteau (CWS) Index

    ERIC Educational Resources Information Center

    Witteman, Cilia L. M.; Weiss, David J.; Metzmacher, Martin

    2012-01-01

    Counseling studies have shown that increasing experience is not always associated with better judgments. However, in such studies performance is assessed against external criteria, which may lack validity. The authors applied the Cochran-Weiss-Shanteau (CWS) index, which assesses the ability to consistently discriminate. Results showed that novice…

  19. Small Sample Comparisons of the Cochran Q and the Minimum X sub one squared Statistics.

    ERIC Educational Resources Information Center

    Vitaliano, Peter Paul

    The Cochran Q and the Minimum X sub one squared statistics are two ways to test a hypothesis of equivalent correlated proportions. This study investigated the small sample properties of Q and X sub one squared by Monte Carlo methods. The observed distributions were compared for their rates of covergence to the limiting theoretical X sub one…

  20. 78 FR 62678 - Morris W. Cochran, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-22

    ...13-17] Morris W. Cochran, M.D.; Decision and Order On July 9...dispense controlled substances. R.D. at 12-13. Applying longstanding...plenary, administrative hearing. See Larry Elbert Perry, M.D., 77 FR 67,671 (DEA...

  1. Treatment of Varicocele in Subfertile Men: The Cochrane Review – A Contrary Opinion

    Microsoft Academic Search

    Vincenzo Ficarra; Maria Angela Cerruto; Giovanni Liguori; Guglielmo Mazzoni; Sergio Minucci; Angelo Tracia; Vincenzo Gentile

    2006-01-01

    ObjectiveA recent Cochrane meta-analysis of randomised clinical trials (RCTs) concluded that surgical or radiological treatment of varicocele in men from couples with otherwise unexplained subfertility cannot be recommended. The aim of the present study is to address criticisms of this review carrying out a critical analysis of all available RCTs.

  2. Ideology and Reform in Teacher Education in England: Some Reflections on Cochran-Smith and Fries.

    ERIC Educational Resources Information Center

    Furlong, John

    2002-01-01

    Presents an international perspective on Cochran-Smith and Fries' recent analysis of the ways that two competing ideologies (deregulation and professionalization) are being employed in the United States to support teacher education reform, noting important differences between the United States and England in how these ideologies have been advanced…

  3. Ideology and Reform in Teacher Education in England: Some Reflections on Cochran-Smith and Fries

    Microsoft Academic Search

    John Furlong

    2002-01-01

    This article presents an international perspective on Cochran-Smith and Fries’ (2001) recent analysis of the ways in which two competing ideologies are currently being employed in the United States in support of teacher education reform. In England over the last 15 years, teacher education has been fundamentally reformed and the arguments of both the “deregulators” and the “professionalizers” have been

  4. NEW CONSTRUCTIONS OF SLICE LINKS TIM COCHRAN, STEFAN FRIEDL AND PETER TEICHNER

    E-print Network

    Friedl, Stefan

    NEW CONSTRUCTIONS OF SLICE LINKS TIM COCHRAN, STEFAN FRIEDL AND PETER TEICHNER ABSTRACT. We use-infection of a slice link is again slice (not necessarily smoothly slice). We provide a general context for proving links are slice that includes most of the previously known results. 1. INTRODUCTION A link of m

  5. What time-lag for a retraction search on PubMed?

    PubMed Central

    2014-01-01

    Background To investigate fraud and errors, scientists have studied cohorts of retraction notices. These researches have been performed using a PubMed search on publication type “retraction of publication” which retrieves the notices of the retractions. We assessed the stability of the indexation of retraction notices over a 15-month period and what was the time-lag to get stability. Findings A search on notices of retraction issued in 2008 was repeated every 3 months during 15 months from February 2011. The first search resulted in 237 notices of retraction. Throughout the study period, 14 discrepancies with the initial search were observed (6%). We found that the number of retraction notices became stable 35 months after the retraction. Conclusions The time-lag observed in this study has to be taken into account when performing a PubMed search. PMID:24965905

  6. Increasing dominance of English in publications archived by PubMed

    Microsoft Academic Search

    Politimi Eleni Valkimadi; Drosos E. Karageorgopoulos; Harissios Vliagoftis; Matthew E. Falagas

    2009-01-01

    English is becoming the international language in numerous fields of human civilization. We sought to evaluate the extent\\u000a of use of English in the field of biomedical publications. We searched in PubMed for the number of articles written in the\\u000a 57 indexed languages, during each one of the four past 10-year periods. The extent of use of English as the

  7. Bibliometric analysis on retinoblastoma literatures in PubMed during 1929 to 2010

    PubMed Central

    Zhao, Zhi-Guang; Guo, Xue-Gang; Xu, Chang-Tai; Pan, Bo-Rong; Xu, Li-Xian

    2011-01-01

    AIM To determine the growth rule and tendency of retinoblastoma (Rb) literature, and to provide the basis for research of diagnosis, treatment and on Rb. METHODS Bibliometric analyses were carried out on Rb literatures which contain the descriptors of Rb in their titles or texts from 1929 to 2010 in PubMed database (www.ncbi.nlm.nih.gov/Pubmed). The biomedical journals referring to Rb by using bibliometric indicators were calculated. The principal bibliometric indicators, i.e., Price's and Bradford's laws to the increase or distribution of scientific literature, the participation index of languages and the journals were applied. By means of manual coding, Rb documents were classified according to documents studied and to statistical analysis. RESULTS During 1929-2010, there were 16162 literatures in the PubMed database including the word Rb. According to the literature type, it includes Review (n=2026), Randomized Controlled Trial (n=7), Practice guideline (n=3), meta-analysis (n=4), letter (n=215), editorial (n=98), clinical trial (n=115) and others (n=13694). By the statistical analysis, its equation is near power index (y=3.0477x2.6088, R2=0.9666). From 1929 to 2010, Rb literatures in English were primarily dominant (90.71%) and the amount of the literature in Chinese ranked the fourth (1.37%). By searching PubMed, 1420(8.8%) literatures covered were from 41 of 48 ophthalmological, and 406 (2.5%) literatures from 44 of 86 pediatrics journals that correlated with retinoblastoma (SCI-indexed). The data showed that the literatures of Rb were gradually increasing year by year and were approximate near power index during 1929-2010, and the document publishes published mainly in ophthalmological journals, and in English (90.71%), and showing that the study on Rb is a popular subject in the last half century. CONCLUSION The literatures of Rb are gradually increasing, mainly English in ophthalmologic journals. PMID:22553624

  8. A study of abbreviations in MEDLINE abstracts.

    PubMed

    Liu, Hongfang; Aronson, Alan R; Friedman, Carol

    2002-01-01

    Abbreviations are widely used in writing, and the understanding of abbreviations is important for natural language processing applications. Abbreviations are not always defined in a document and they are highly ambiguous. A knowledge base that consists of abbreviations with their associated senses and a method to resolve the ambiguities are needed. In this paper, we studied the UMLS coverage, textual variants of senses, and the ambiguity of abbreviations in MEDLINE abstracts. We restricted our study to three-letter abbreviations which were defined using parenthetical expressions. When grouping similar expansions together and representing senses using groups, we found that after ignoring senses where the total number of occurrences within the corresponding group was less than 100, 82.8% of the senses matched the UMLS, covered over 93% of occurrences that were considered, and had an average of 7.74 expansions for each sense. Abbreviations are highly ambiguous: 81.2% of the abbreviations were ambiguous, and had an average of 16.6 senses. However, after ignoring senses with occurrences of less than 5, 64.6% of the abbreviations were ambiguous, and had an average of 4.91 senses. PMID:12463867

  9. Issues in the incorporation of economic perspectives and evidence into Cochrane reviews

    PubMed Central

    2013-01-01

    Background Methods for systematic reviews of the effects of health interventions have focused mainly on addressing the question of 'What works?’ or 'Is this intervention effective in achieving one or more specific outcomes?’ Addressing the question 'Is it worth it given the resources available?’ has received less attention. This latter question can be addressed by applying an economic lens to the systematic review process. This paper reflects on the value and desire for the consideration by end users for coverage of an economic perspective in a Cochrane review and outlines two potential approaches and future directions. Methods Two frameworks to guide review authors who are seeking to include an economic perspective are outlined. The first involves conducting a full systematic review of economic evaluations that is integrated into a review of intervention effects. The second involves developing a brief economic commentary. The two approaches share a set of common stages but allow the tailoring of the economic component of the Cochrane review to the skills and resources available to the review team. Results The number of studies using the methods outlined in the paper is limited, and further examples are needed both to explore the value of these approaches and to further develop them. The rate of progress will hinge on the organisational leadership, capacity and resources available to the CCEMG, author teams and other Cochrane entities. Particular methodological challenges to overcome relate to understanding the key economic trade-offs and casual relationships for a given decision problem and informing the development of evaluations designed to support local decision-makers. Conclusions Methods for incorporating economic perspectives and evidence into Cochrane intervention reviews are established. Their role is not to provide a precise estimate of 'cost-effectiveness’ but rather to help end-users of Cochrane reviews to determine the implications of the economic components of reviews for their own specific decisions. PMID:24050504

  10. PubMed and beyond: a survey of web tools for searching biomedical literature

    PubMed Central

    Lu, Zhiyong

    2011-01-01

    The past decade has witnessed the modern advances of high-throughput technology and rapid growth of research capacity in producing large-scale biological data, both of which were concomitant with an exponential growth of biomedical literature. This wealth of scholarly knowledge is of significant importance for researchers in making scientific discoveries and healthcare professionals in managing health-related matters. However, the acquisition of such information is becoming increasingly difficult due to its large volume and rapid growth. In response, the National Center for Biotechnology Information (NCBI) is continuously making changes to its PubMed Web service for improvement. Meanwhile, different entities have devoted themselves to developing Web tools for helping users quickly and efficiently search and retrieve relevant publications. These practices, together with maturity in the field of text mining, have led to an increase in the number and quality of various Web tools that provide comparable literature search service to PubMed. In this study, we review 28 such tools, highlight their respective innovations, compare them to the PubMed system and one another, and discuss directions for future development. Furthermore, we have built a website dedicated to tracking existing systems and future advances in the field of biomedical literature search. Taken together, our work serves information seekers in choosing tools for their needs and service providers and developers in keeping current in the field. Database URL: http://www.ncbi.nlm.nih.gov/CBBresearch/Lu/search PMID:21245076

  11. NEMO: Extraction and normalization of organization names from PubMed affiliation strings

    PubMed Central

    Jonnalagadda, Siddhartha; Topham, Philip

    2010-01-01

    Background. We are witnessing an exponential increase in biomedical research citations in PubMed. However, translating biomedical discoveries into practical treatments is estimated to take around 17 years, according to the 2000 Yearbook of Medical Informatics, and much information is lost during this transition. Pharmaceutical companies spend huge sums to identify opinion leaders and centers of excellence. Conventional methods such as literature search, survey, observation, self-identification, expert opinion, and sociometry not only need much human effort, but are also noncomprehensive. Such huge delays and costs can be reduced by “connecting those who produce the knowledge with those who apply it”. A humble step in this direction is large scale discovery of persons and organizations involved in specific areas of research. This can be achieved by automatically extracting and disambiguating author names and affiliation strings retrieved through Medical Subject Heading (MeSH) terms and other keywords associated with articles in PubMed. In this study, we propose NEMO (Normalization Engine for Matching Organizations), a system for extracting organization names from the affiliation strings provided in PubMed abstracts, building a thesaurus (list of synonyms) of organization names, and subsequently normalizing them to a canonical organization name using the thesaurus. Results: We used a parsing process that involves multi-layered rule matching with multiple dictionaries. The normalization process involves clustering based on weighted local sequence alignment metrics to address synonymy at word level, and local learning based on finding connected components to address synonymy. The graphical user interface and java client library of NEMO are available at http://lnxnemo.sourceforge.net . Conclusion: NEMO is developed to associate each biomedical paper and its authors with a unique organization name and the geopolitical location of that organization. This system provides more accurate information about organizations than the raw affiliation strings provided in PubMed abstracts. It can be used for : a) bimodal social network analysis that evaluates the research relationships between individual researchers and their institutions; b) improving author name disambiguation; c) augmenting National Library of Medicine (NLM)’s Medical Articles Record System (MARS) system for correcting errors due to OCR on affiliation strings that are in small fonts; and d) improving PubMed citation indexing strategies (authority control) based on normalized organization name and country. PMID:20922666

  12. 28. W. W. Cochran, M. Wikelski, in Birds of Two Worlds, P. Marra, R. Greenberg, Eds. (Johns Hopkins Press, Baltimore,

    E-print Network

    Falkowski, Paul G.

    measurements and thank M. Bowlin, N. Sapir, A. Medina, W. Cochran, J. Cochran, J. Mandel, and S. David with high silicic acid in the south and low silicic acid in the north, where diatom growth may be limited by both silicic acid and iron

  13. Down the Block... Around the World...MedlinePlus.gov

    MedlinePLUS

    ... Issue Past Issues Down the Block... Around the World...MedlinePlus.gov Past Issues / Spring 2008 Table of ... on. No matter where you are in the world, www.medlineplus.gov is your best global source ...

  14. Treating Cataracts | NIH MedlinePlus the Magazine

    MedlinePLUS

    ... her experience recently with NIH MedlinePlus magazine. What did you notice about your vision that told you ... how long it would take to recover. Where did you go for information about cataracts and surgery? ...

  15. MedlinePlus FAQ: Information on Doctors or Hospitals

    MedlinePLUS

    ... Where can I find information on doctors or hospitals? To use the sharing features on this page, ... of information about physicians, other health professionals, and health facilities. MedlinePlus does not produce the content of these ...

  16. MEDLINE training for medical students integrated into the clinical curriculum.

    PubMed

    Schwartz, D G; Schwartz, S A

    1995-03-01

    This study was initiated in response to the availabilty of unlimited access to MEDLINE via the PaperChase interface at the host institution. The goal of the study was to analyse the usage of MEDLINE by medical students during their third-year clinical clerkship in paediatrics. This was achieved by first giving them a formal demonstration of MEDLINE and then longitudinally administering a structured questionnaire at several points during their paediatric clerkship. Since medical students were required to write a thesis for this clerkship, which included an analysis of the primary literature, there was an identified need for using the system. This study analyses the students' perceptions and searching activities after formal training and upon having unlimited access to MEDLINE. PMID:7623700

  17. MedlinePlus en español marks its 10th anniversary

    MedlinePLUS

    ... of authoritative, reliable consumer-level health information in Spanish from the National Institutes of Health and national ... public can use. Making MedlinePlus information available in Spanish greatly expands NIH's ability to carry out its ...

  18. Mary Tyler Moore Helps Launch NIH MedlinePlus Magazine

    MedlinePLUS

    ... Regula (R-OH), Mary Tyler Moore, former Rep. Paul Rogers, and NLM Director Dr. Donald Lindberg. Photo ... receive a free subscription to NIH MedlinePlus . Sincerely, Paul G. Rogers Chairman Friends of the National Library ...

  19. Archibald Cochrane (1909–1988): the father of evidence-based medicine

    PubMed Central

    Stavrou, Antonio; Challoumas, Dimitrios; Dimitrakakis, Georgios

    2014-01-01

    Professor Archibald Cochrane (1909–1988) is considered to be the originator of the idea of evidence-based medicine in our era. With his landmark book ‘Effectiveness and Efficiency: Random Reflections on Health services’ he managed to inspire and positively influence the medical society with respect to the proper assessment of reliable evidence for the provision of the best medical care. His vision combined with his scientific achievements can be considered as the foundation of the Cochrane Collaboration; named after him in recognition of and gratitude for his pioneering work. We present the highlights of his adventurous and vibrant personal and academic life in an attempt to honour his contribution to shaping modern medical research. PMID:24140816

  20. Evaluating the effectiveness of public health interventions: the role and activities of the Cochrane Collaboration

    PubMed Central

    Waters, Elizabeth; Doyle, Jodie; Jackson, Nicki; Howes, Faline; Brunton, Ginny; Oakley, Ann

    2006-01-01

    Public health decision makers, funders, practitioners, and the public are increasingly interested in the evidence that underpins public health decision making. Decisions in public health cover a vast range of activities. With the ever increasing global volume of primary research, knowledge and changes in thinking and approaches, quality systematic reviews of all the available research that is relevant to a particular practice or policy decision are an efficient way to synthesise and utilise research efforts. The Cochrane Collaboration includes an organised entity that aims to increase the quality and quantity of public health systematic reviews, through a range of activities. This paper aims to provide a glossary of the terms and activities related to public health and the Cochrane Collaboration. PMID:16537343

  1. Archibald Cochrane (1909-1988): the father of evidence-based medicine.

    PubMed

    Stavrou, Antonio; Challoumas, Dimitrios; Dimitrakakis, Georgios

    2014-01-01

    Professor Archibald Cochrane (1909-1988) is considered to be the originator of the idea of evidence-based medicine in our era. With his landmark book 'Effectiveness and Efficiency: Random Reflections on Health services' he managed to inspire and positively influence the medical society with respect to the proper assessment of reliable evidence for the provision of the best medical care. His vision combined with his scientific achievements can be considered as the foundation of the Cochrane Collaboration; named after him in recognition of and gratitude for his pioneering work. We present the highlights of his adventurous and vibrant personal and academic life in an attempt to honour his contribution to shaping modern medical research. PMID:24140816

  2. Creating the First MedlinePlus “Go Local” Service

    Microsoft Academic Search

    Christie Silbajoris; Diana McDuffee; Cynthia Olney

    2007-01-01

    NC Health Info is an online collection of North Carolina-based health services Web sites that seamlessly links local health resources to topical health information on MedlinePlus, the National Library of Medicine's consumer health information Web site. NC Health Info was the first project to connect local resources with MedlinePlus in the “Go Local” initiative. As such, NC Health Info serves

  3. Assessing bias in osteoarthritis trials included in Cochrane reviews: protocol for a meta-epidemiological study

    PubMed Central

    Hansen, Julie B; Juhl, Carsten B; Boutron, Isabelle; Tugwell, Peter; Ghogomu, Elizabeth A T; Pardo Pardo, Jordi; Rader, Tamara; Wells, George A; Mayhew, Alain; Maxwell, Lara; Lund, Hans; Christensen, Robin

    2014-01-01

    Introduction The validity of systematic reviews and meta-analysis depends on methodological quality and unbiased dissemination of trials. Our objective is to evaluate the association of estimates of treatment effects with different bias-related study characteristics in meta-analyses of interventions used for treating pain in osteoarthritis (OA). From the findings, we hope to consolidate guidance on interpreting OA trials in systematic reviews based on empirical evidence from Cochrane reviews. Methods and analysis Only systematic reviews that compare experimental interventions with sham, placebo or no intervention control will be considered eligible. Bias will be assessed with the risk of bias tool, used according to the Cochrane Collaboration’s recommendations. Furthermore, center status, trial size and funding will be assessed. The primary outcome (pain) will be abstracted from the first appearing forest plot for overall pain in the Cochrane review. Treatment effect sizes will be expressed as standardised mean differences (SMDs), where the difference in mean values available from the forest plots is divided by the pooled SD. To empirically assess the risk of bias in treatment benefits, we will perform stratified analyses of the trials from the included meta-analyses and assess the interaction between trial characteristics and treatment effect. A relevant study-level covariate is defined as one that decreases the between-study variance (?2, estimated as Tau-squared) as a consequence of inclusion in the mixed effects statistical model. Ethics and dissemination Meta-analyses and randomised controlled trials provide the most reliable basis for treatment of patients with OA, but the actual impact of bias is unclear. This study will systematically examine the methodological quality in OA Cochrane reviews and explore the effect estimates behind possible bias. Since our study does not collect primary data, no formal ethical assessment and informed consent are required. Trial registration number PROSPERO (CRD42013006924). PMID:25280805

  4. Qatar biomedical and cancer publications in PubMed between 2000 and 2012

    PubMed Central

    Zeeneldin, Ahmed A.; Taha, Fatma Mohamed

    2014-01-01

    Background: The aim of this work was to analyse the past trends of biomedical and cancer publications from Qatar listed on PubMed for the years 2000–2012. These findings were then compared with the corresponding global number of publications. Methods: PubMed was searched for cancer publications, clinical trials, publications on humans or other species. Searching for “Qatar*” in the “Affiliation” field yielded the lowest number of publications; searching for “Qatar*” in the “Affiliation” or in “Title/Abstract” yielded a moderate number of results and searching for “Qatar*” in the “Affiliation” or “Title/Abstract” or “Text Word” fields yielded the highest number of publications. The annual percentage change (APC) from one year to the next was calculated for the population and each type of publication. Information on the population of Qatar was gathered from the website of Qatar Statistics Authority to determine the correlation of papers published per 1000 population. Results: The number of publications retrieved from PubMed was not particularly different for each variation of search carried out. However, the most representative number of publications was retrieved upon searching for “Qatar*” in the “Affiliation” or in “Title/Abstract” fields. Between the years 2000 and 2012, the total number of biomedical publications from Qatar increased 24 times with an average APC of 33.4%, which was found to be more than the APC of the population in Qatar which averaged at 9%. The number of biomedical publications per 1000 population increased from 0.02 in 2000 to 0.15% in 2012. Most publications retrieved were humans studies and occasionally were for other animal species. Cancer publications in Qatar represented 16.9% of the total publications and the number of cancer publications per 1000 population increased from 0% in 2000 to 0.02% in 2012. Publications classified as clinical trials represented 4.6% of Qatar biomedical publications. Publication of cancer clinical trials were very rare (0.4%). Conclusions: Despite the obvious increase in Qatar biomedical and cancer publications in PubMed, the absolute numbers were relatively small. While strategies are in place, leaders of Qatar biomedical research need to consider increasing cancer research and clinical trials to meet the country's needs. Linking research output to researchers, research facilities and research funding is needed. PMID:25320690

  5. Beyond PubMed: Searching the “Grey Literature” for Clinical Trial Results

    PubMed Central

    2014-01-01

    Clinical trial results have been traditionally communicated through the publication of scholarly reports and reviews in biomedical journals. However, this dissemination of information can be delayed or incomplete, making it difficult to appraise new treatments, or in the case of missing data, evaluate older interventions. Going beyond the routine search of PubMed, it is possible to discover additional information in the “grey literature.” Examples of the grey literature include clinical trial registries, patent databases, company and industrywide repositories, regulatory agency digital archives, abstracts of paper and poster presentations on meeting/congress websites, industry investor reports and press releases, and institutional and personal websites. PMID:25337445

  6. Utilization of the PICO framework to improve searching PubMed for clinical questions

    PubMed Central

    Schardt, Connie; Adams, Martha B; Owens, Thomas; Keitz, Sheri; Fontelo, Paul

    2007-01-01

    Background Supporting 21st century health care and the practice of evidence-based medicine (EBM) requires ubiquitous access to clinical information and to knowledge-based resources to answer clinical questions. Many questions go unanswered, however, due to lack of skills in formulating questions, crafting effective search strategies, and accessing databases to identify best levels of evidence. Methods This randomized trial was designed as a pilot study to measure the relevancy of search results using three different interfaces for the PubMed search system. Two of the search interfaces utilized a specific framework called PICO, which was designed to focus clinical questions and to prompt for publication type or type of question asked. The third interface was the standard PubMed interface readily available on the Web. Study subjects were recruited from interns and residents on an inpatient general medicine rotation at an academic medical center in the US. Thirty-one subjects were randomized to one of the three interfaces, given 3 clinical questions, and asked to search PubMed for a set of relevant articles that would provide an answer for each question. The success of the search results was determined by a precision score, which compared the number of relevant or gold standard articles retrieved in a result set to the total number of articles retrieved in that set. Results Participants using the PICO templates (Protocol A or Protocol B) had higher precision scores for each question than the participants who used Protocol C, the standard PubMed Web interface. (Question 1: A = 35%, B = 28%, C = 20%; Question 2: A = 5%, B = 6%, C = 4%; Question 3: A = 1%, B = 0%, C = 0%) 95% confidence intervals were calculated for the precision for each question using a lower boundary of zero. However, the 95% confidence limits were overlapping, suggesting no statistical difference between the groups. Conclusion Due to the small number of searches for each arm, this pilot study could not demonstrate a statistically significant difference between the search protocols. However there was a trend towards higher precision that needs to be investigated in a larger study to determine if PICO can improve the relevancy of search results. PMID:17573961

  7. Updated method guidelines for cochrane musculoskeletal group systematic reviews and metaanalyses.

    PubMed

    Ghogomu, Elizabeth A T; Maxwell, Lara J; Buchbinder, Rachelle; Rader, Tamara; Pardo Pardo, Jordi; Johnston, Renea V; Christensen, Robin D K; Rutjes, Anne W S; Winzenberg, Tania M; Singh, Jasvinder A; Zanoli, Gustavo; Wells, George A; Tugwell, Peter

    2014-02-01

    The Cochrane Musculoskeletal Group (CMSG), one of 53 groups of the not-for-profit, international Cochrane Collaboration, prepares, maintains, and disseminates systematic reviews of treatments for musculoskeletal diseases. It is important that authors conducting CMSG reviews and the readers of our reviews be aware of and use updated, state-of-the-art systematic review methodology. One hundred sixty reviews have been published. Previous method guidelines for systematic reviews of interventions in the musculoskeletal field published in 2006 have been substantially updated to incorporate methodological advances that are mandatory or highly desirable in Cochrane reviews and knowledge translation advances. The methodological advances include new guidance on searching, new risk-of-bias assessment, grading the quality of the evidence, the new Summary of Findings table, and comparative effectiveness using network metaanalysis. Method guidelines specific to musculoskeletal disorders are provided by CMSG editors for various aspects of undertaking a systematic review. These method guidelines will help improve the quality of reporting and ensure high standards of conduct as well as consistency across CMSG reviews. PMID:24293581

  8. [Analysis of the Cochrane review: Anticoagulation versus placebo for heart failure in sinus rhythm. Cochrane Database Syst Rev. 2014;3:CD003336].

    PubMed

    Caldeira, Daniel; Vaz-Carneiro, António; Costa, João

    2014-01-01

    Thrombotic and embolic events contribute to the morbidity and mortality associated to Chronic Heart Failure (HF). Differently from patients with atrial fibrillation (AF) and HF, in which the benefit of anticoagulation is well documented, the use of these drugs in those with HF in sinus rhythm (without AF history) is controversial. In this systematic review from the Cochrane Collaboration, the authors evaluated the benefits and risks associated with oral anticoagulation (versus placebo) in this population. Only 2 randomized controlled trials were published (one with open-label design) enrolling a total of 324 patients. The results of the meta-analysis based on the best available evidence do not support the systematic use of oral anticoagulants in patients with HF and sinus rhythm for preventing death (overall or cardiovascular) or non-fatal cardiovascular events. Furthermore the major bleeding risk was significantly increased. PMID:25017336

  9. The Method Quality of Cross-Over Studies Involved in Cochrane Systematic Reviews

    PubMed Central

    Zheng, Xue Yan; Chen, Qing; Threapleton, Diane Erin; Zhou, Zeng Huan

    2015-01-01

    Background It is possible that cross-over studies included in current systematic reviews are being inadequately assessed, because the current risk of bias tools do not consider possible biases specific to cross-over design. We performed this study to evaluate whether this was being done in cross-over studies included in Cochrane Systematic Reviews (CSRs). Methods We searched the Cochrane Library (up to 2013 issue 5) for CSRs that included at least one cross-over trial. Two authors independently undertook the study selection and data extraction. A random sample of the CSRs was selected and we evaluated whether the cross-over trials in these CSRs were assessed according to criteria suggested by the Cochrane handbook. In addition we reassessed the risk of bias of these cross-over trials by a checklist developed form the Cochrane handbook. Results We identified 688 CSRs that included one or more cross-over studies. We chose a random sample of 60 CSRs and these included 139 cross-over studies. None of these CSRs undertook a risk of bias assessment specific for cross-over studies. In fact items specific for cross-over studies were seldom considered anywhere in quality assessment of these CSRs. When we reassessed the risk of bias, including the 3 items specific to cross-over trials, of these 139 studies, a low risk of bias was judged for appropriate cross-over design in 110(79%), carry-over effects in 48(34%) and for reporting data in all stages of the trial in 114(82%).Assessment of biases in cross-over trials could affect the GRADE assessment of a review’s findings. Conclusion The current Cochrane risk of bias tool is not adequate to assess cross-over studies. Items specific to cross-over trials leading to potential risk of bias are generally neglected in CSRs. A proposed check list for the evaluation of cross-over trials is provided. PMID:25867772

  10. History and Trends of "Personal Health Record" Research in PubMed

    PubMed Central

    Kim, Jeongeun; Bates, David W.

    2011-01-01

    Objectives The purpose of this study was to review history and trends of personal health record research in PubMed and to provide accurate understanding and categorical analysis of expert opinions. Methods For the search strategy, PubMed was queried for 'personal health record, personal record, and PHR' in the title and abstract fields. Those containing different definitions of the word were removed by one-by-one analysis from the results, 695 articles. In the end, total of 229 articles were analyzed in this research. Results The results show that the changes in terms over the years and the shift to patient centeredness and mixed usage. And we identified history and trend of PHR research in some category that the number of publications by year, topic, methodologies and target diseases. Also from analysis of MeSH terms, we can show the focal interest in regards the PHR boundaries and related subjects. Conclusions For PHRs to be efficiently used by general public, initial understanding of the history and trends of PHR research may be helpful. Simultaneously, accurate understanding and categorical analysis of expert opinions that can lead to the development and growth of PHRs will be valuable to their adoption and expansion. PMID:21818452

  11. Concordance of Adherence Measurement Using Self-Reported Adherence Questionnaires and Medication Monitoring Devices

    Microsoft Academic Search

    Lizheng Shi; Jinan Liu; Yordanka Koleva; Vivian Fonseca; Anupama Kalsekar; Manjiri Pawaskar

    2010-01-01

    The primary objective of this review was to identify and examine the literature on the association between medication adherence self-reported questionnaires (SRQs) and medication monitoring devices. The primary literature search was performed for 1980-2009 using PubMed, PubMed In Process and Non-Indexed, Ovid MEDLINE, Ovid MEDLINE In-Process, PsycINFO (EBSCO), CINAHL (EBSCO), Ovid HealthStar, EMBASE (Elsevier) and Cochrane Databases and using the

  12. Interactive text mining with Pipeline Pilot: a bibliographic web-based tool for PubMed.

    PubMed

    Vellay, S G P; Latimer, N E Miller; Paillard, G

    2009-06-01

    Text mining has become an integral part of all research in the medical field. Many text analysis software platforms support particular use cases and only those. We show an example of a bibliographic tool that can be used to support virtually any use case in an agile manner. Here we focus on a Pipeline Pilot web-based application that interactively analyzes and reports on PubMed search results. This will be of interest to any scientist to help identify the most relevant papers in a topical area more quickly and to evaluate the results of query refinement. Links with Entrez databases help both the biologist and the chemist alike. We illustrate this application with Leishmaniasis, a neglected tropical disease, as a case study. PMID:19519489

  13. A Search Engine to Access PubMed Monolingual Subsets: Proof of Concept and Evaluation in French

    PubMed Central

    Schuers, Matthieu; Soualmia, Lina Fatima; Grosjean, Julien; Kerdelhué, Gaétan; Kergourlay, Ivan; Dahamna, Badisse; Darmoni, Stéfan Jacques

    2014-01-01

    Background PubMed contains numerous articles in languages other than English. However, existing solutions to access these articles in the language in which they were written remain unconvincing. Objective The aim of this study was to propose a practical search engine, called Multilingual PubMed, which will permit access to a PubMed subset in 1 language and to evaluate the precision and coverage for the French version (Multilingual PubMed-French). Methods To create this tool, translations of MeSH were enriched (eg, adding synonyms and translations in French) and integrated into a terminology portal. PubMed subsets in several European languages were also added to our database using a dedicated parser. The response time for the generic semantic search engine was evaluated for simple queries. BabelMeSH, Multilingual PubMed-French, and 3 different PubMed strategies were compared by searching for literature in French. Precision and coverage were measured for 20 randomly selected queries. The results were evaluated as relevant to title and abstract, the evaluator being blind to search strategy. Results More than 650,000 PubMed citations in French were integrated into the Multilingual PubMed-French information system. The response times were all below the threshold defined for usability (2 seconds). Two search strategies (Multilingual PubMed-French and 1 PubMed strategy) showed high precision (0.93 and 0.97, respectively), but coverage was 4 times higher for Multilingual PubMed-French. Conclusions It is now possible to freely access biomedical literature using a practical search tool in French. This tool will be of particular interest for health professionals and other end users who do not read or query sufficiently in English. The information system is theoretically well suited to expand the approach to other European languages, such as German, Spanish, Norwegian, and Portuguese. PMID:25448528

  14. Towards automatic augmentation of electronic medical records with MEDLINE citations.

    PubMed

    Chacko, Vinod

    2007-01-01

    The adoption of Electronic Medical Records (EMR)is increasing every year even though the rate of adoption is slow. MEDLINE is adding thousands of new citations every day. It may be possible to enrich an EMR system with relevant information from NLM resources. During my elective at NLM I was assigned to evaluate the preliminary stages in designing and building a system, which automatically augment a patient's EMR with pertinent information from NLM resources. Clinical informatics experiments using content from real EMR is necessary to achieve the ultimate goal of automatic augmentation of the EMR with MEDLINE. PMID:18693995

  15. [Analysis of the Cochrane Review: Use of systemic corticosteroids for acute exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2014, 9:CD001288].

    PubMed

    Azevedo, Pedro; Costa, João; Vaz-Carneiro, António

    2014-01-01

    Acute exacerbations of chronic obstructive pulmonary disease are a major cause of hospital admissions and mortality, contributing to the decline in lung function, exercise capacity and quality of life. Infections are the major cause of exacerbations and treatment includes antibiotics, bronchodilators and systemic corticosteroids as anti- inflammatory agents. This Cochrane review compared: 1. use of oral and parenteral corticosteroids with placebo use; 2. routes of administration among themselves. The results indicate that there is evidence for the use of corticosteroids in the treatment of chronic obstructive pulmonary disease exacerbations since early improvement in lung function [assessed by forced expiratory volume in one second (FEV1)] has been noted, the likelihood of treatment failure and relapse in the first month has been reduced and it shortens the hospital stay in patients who do not require intensive care regimen. However, corticosteroid therapy causes an increase in adverse effects associated with drug, namely hyperglycaemia, especially if the route of administration is parenteral. Parenteral route has not shown to be superior to oral route in treatment failure, relapse, or death. Mortality up to 30 days does not seem to be affected by the use of corticosteroids. PMID:25409206

  16. [Analysis of the Cochrane Review: Vitamin D supplementation for prevention of cancer in adults. Cochrane Database Syst Rev. 2014, 6:CD007469].

    PubMed

    Cardoso, André Torres; Nanji, Liliana; Costa, João; Vaz-Carneiro, António

    2014-01-01

    Vitamin D has been mentioned in the literature has a potentially important agent for preventing the development of tumors, namely breast, colon, prostate and ovary tumors. However, the currently available evidence on the subject is contradictory and inconclusive. In this Cochrane systematic review, patients taking supplemental vitamin D on its various forms (cholecalciferol, ergocalciferol, alfacalcidol or calcitriol), regardless the dose, duration and route of administration, were compared with placebo, healthy adults without any intervention or adults with a disease in a stable phase, non-related with vitamin D metabolism. The results showed that currently, there is no firm evidence that vitamin D supplementation increases or decreases the risk of cancer occurrence, mainly in elderly community-dwelling women. Though at risk of type I errors due to small samples and substantial dropout of participants during the trials, the administration of supplemental cholecalciferol led to a 12% (CI 95%: 2 a 22%) decreased in cancer mortality, while the administration of supplemental vitamin D decreased all-cause mortality by 7% (CI 95%: 2 a 12%). The combined administration of supplements of cholecalciferol and calcium induced an increased incidence of nephrolithiasis. PMID:25203945

  17. Clinical trials of investigational agents for IPF: a review of a Cochrane report.

    PubMed

    Richeldi, Luca

    2013-01-01

    The magnitude of treatment effect can be assessed by a number of methods. One reliable method of collectively analysing data from randomised clinical trials is that used in Cochrane reviews. These systematic reviews identify and analyse the available evidence using the reliable method of meta-analysis. These often combine data from studies to provide robust evaluations of overall treatment effects. In 2003, a review of data from studies of corticosteroid use in IPF patients found no evidence of a treatment effect. Similarly, very little evidence was found to support the use of immunomodulatory agents. A recent update of these Cochrane reviews failed to identify any new evidence supporting the use of corticosteroids in IPF. However, a review of non-steroid agents for the treatment of IPF identified data from 15 RCTs that was suitable for analysis. Two trials of interferon gamma-1b were pooled and analysed, but no treatment effect was observed in terms of survival. Meta-analysis of three Phase III studies of pirfenidone treatment in IPF patients suggested that progression-free survival was significantly increased by 30%, demonstrating a reduction in the decline of lung function in IPF patients. In addition, there are numerous ongoing trials investigating potential therapeutic agents which provides hope for IPF patients and their doctors. PMID:23734867

  18. Study flow diagrams in Cochrane systematic review updates: an adapted PRISMA flow diagram.

    PubMed

    Stovold, Elizabeth; Beecher, Deirdre; Foxlee, Ruth; Noel-Storr, Anna

    2014-01-01

    Cochrane systematic reviews are conducted and reported according to rigorous standards. A study flow diagram must be included in a new review, and there is clear guidance from the PRISMA statement on how to do this. However, for a review update, there is currently no guidance on how study flow diagrams should be presented. To address this, a working group was formed to find a solution and produce guidance on how to use these diagrams in review updates.A number of different options were devised for how these flow diagrams could be used in review updates, and also in cases where multiple searches for a review or review update have been conducted. These options were circulated to the Cochrane information specialist community for consultation and feedback. Following the consultation period, the working group refined the guidance and made the recommendation that for review updates an adapted PRISMA flow diagram should be used, which includes an additional box with the number of previously included studies feeding into the total. Where multiple searches have been conducted, the results should be added together and treated as one set of results.There is no existing guidance for using study flow diagrams in review updates. Our adapted diagram is a simple and pragmatic solution for showing the flow of studies in review updates. PMID:24886533

  19. Don't Panic! | NIH MedlinePlus the Magazine

    MedlinePLUS

    ... treatment for the anxiety disorder. Effective therapies for phobias and other anxiety disorders are available, and research is uncovering new treatments that can help. To Find Out More MedlinePlus: www.medlineplus.gov , type "anxiety disorders" in the Search box National Institute ...

  20. Protect Yourself Against HPV | NIH MedlinePlus the Magazine

    MedlinePLUS

    ... please turn JavaScript on. Feature: Protect Yourself Against HPV Protect Yourself Against HPV Past Issues / Winter 2014 Table of Contents Find Out More MedlinePlus www.medlineplus.gov Type "HPV" in the Search box. National Cancer Institute —HPV ...

  1. Ranked Set Search in Medline Documents Kristin Mittag1

    E-print Network

    Hinneburg, Alexander

    -information mitigate the problem. However, constructing a boolean query to retrieve for example all randomized clinical papers relevant to a given informa- tion need. Controlled vocabularies like MESH-terms and meta trials on a particular subject that are present in Medline still requires a lot of manual tuning

  2. Portraying Islam and Muslims in MEDLINE: A content analysis

    Microsoft Academic Search

    Lance Daniel Laird; Justine de Marrais; Linda L. Barnes

    2007-01-01

    The growing number and diversity of Muslims in the United States and Western Europe challenge clinicians and researchers to understand this population's perspectives and experiences regarding health and biomedicine. For information about Muslim patient populations, clinicians and researchers routinely consult medical literature. To examine how this literature portrays Muslims, we conducted an ethnographic content analysis of 2342 OVID MEDLINE-indexed abstracts

  3. Language and country preponderance trends in MEDLINE and its causes

    PubMed Central

    Loria, Alvar; Arroyo, Pedro

    2005-01-01

    Objective: The authors characterized the output of MEDLINE papers by language and country of publication during a thirty-four-year time period. Methods: We classified MEDLINE's journal articles by country of publication (Anglos/Non-Anglos) and language (English/Non-English) for the years 1966 and from 1970 to 2000 at five-year intervals. Eight English-speaking countries were considered Anglos. Linear regression analysis of number of papers versus time was performed. Results: The global number of papers increased linearly at a rate of 8,142 papers per year. Anglo and English papers also increased linearly (6,740 and 9,199, respectively). Journals of Non-Anglo countries accounted for 25% of the English language increase (2,438 per year). Only Non-English papers decreased at a rate of 1,056 fewer papers per year. These trends have led to overwhelming shares of English and Anglo papers in MEDLINE. In 2000, 68% of all papers were published in the 8 Anglo countries and 90% were written in English. Conclusions: The Anglo and English preponderances appear to be a consequence of at least two phenomena: (1) editorial policy changes in MEDLINE and in some journals from Non-Anglo countries and (2) factors affecting Non-Anglo researchers in the third world (publication constraints, migration, and undersupport). These are tentative conclusions that need confirmation. PMID:16059428

  4. Déjà vu - A study of duplicate citations in Medline

    Microsoft Academic Search

    Mounir Errami; Justin M. Hicks; Wayne G. Fisher; David Trusty; Jonathan D. Wren; Tara C. Long; Harold R. Garner

    2008-01-01

    Motivation: Duplicate publication impacts the quality of the scien- tific corpus, has been difficult to detect, and studies this far have been limited in scope and size .Using text similarity searches, we were able to identify signatures of duplicate citations among a body of abstracts. Results: A sample of 62,213 Medline citations was examined and a database of manually verified

  5. Coadjuvant analgesics for cancer pain: using the clinical queries PubMed tool.

    PubMed

    Chaparro Gómez, Luis Enrique; Calvache España, José Andrés; Arbeláez León, Lina Marcela

    2010-01-01

    Coadjuvants for cancer pain are medications that, when added to opioids, can potentially decrease narcotic request and opioid-related side effects. Our goal was to review not only the evidence that supports the effectiveness, but also the mechanisms of action of these drugs. We performed a qualitative review using the PubMed database applying the clinical queries tool to identify therapeutic clinical trials or systematic reviews evaluating cancer pain--oral or transdermal--analgesia. We excluded studies using anti-inflammatories, steroids or narcotics as primary analgesia and studies focused on perioperative cancer pain. We supplemented the information describing the mechanisms of action and suggested dosage schemes. We found a qualitative systematic review evaluating ketamine, and randomized trials supporting the use of amitriptyline, gabapentin and transdermal nitroglycerin. We also found some negative trials using gabapentin and lamotrigine for neuropathic pain secondary to chemotherapy. Weak evidence supports intravenous magnesium and lidocaine for breakthrough cancer pain. Further primary research based on clinical trials is required to support some adjuvant analgesics for cancer pain. PMID:20478123

  6. Twelve Years of Scientific Production on Medline by Latin American Spine Surgeons

    PubMed Central

    Falavigna, Asdrubal; Botelho, Ricardo Vieira; Teles, Alisson Roberto; Guarise da Silva, Pedro; Martins, Delio; Guyot, Juan Pablo; Gonzalez, Alvaro Silva; Avila, José Maria Jiménez; Defino, Helton Luiz Aparecido

    2014-01-01

    Background Despite the small contribution of LA in the Science Citation Index (SCI), a growing contribution by LA research to international literature has been observed in recent years. Study Design Systematic review. Purpose To evaluate the scientific contribution of Latin American (LA) Spine Surgeons in the last decade. Methods A literature search of publications by LA spinal surgeons on topics concerning the spine or spinal cord was performed using an online database; Pubmed.gov. The results were limited to articles published from January 2000 to December 2011. The quality of the publication was evaluated with the journal impact factor (IF), Oxford classification and number of citations. Results This study comprised 320 articles published in the Medline database by LA spine surgeons from 2000 to 2011. In recent years, there has been an increase in the number of publications by LA spine surgeons. It was observed that 38.4% of LA papers were published in LA journals. 46.6% of the articles were published in journals with an IF lower than 1, and there was no statistically significant difference in the number of articles published in journals with a higher IF during the period. Linear-by-linear association analysis demonstrated an improvement in the level of evidence provided by LA articles published in recent years. Conclusions This study showed a growth in the number of publications in last 12 years by LA spinal surgeons. It is necessary to discuss a way to increase quantity and quality of scientific publications, mainly through a better education in research. PMID:24505336

  7. Book Review of 'Evolutionary and Interpretive Archaeologies' Edited by Ethan E. Cochrane and Andrew Gardner

    E-print Network

    Gabora, Liane

    2015-01-01

    Evolutionary and Interpretive Archaeologies, edited by Ethan E. Cochrane and Andrew Gardner, grew out of a seminar at the Institute for Archaeology at University College London in 2007. It consists of 15 chapters by archaeologists who self-identify themselves as practitioners who emphasize the benefits of evolutionary or interpretive approaches to the study of the archaeological record. While the authors' theoretical views are dichotomous, the editors' aim for the book as a whole is not to expound on the differences between these two kinds of archaeology but to bring forward a richer understanding of the discipline and to highlight areas of mutual concern. Some chapters come across as a bit of a sales pitch, but the majority of the contributions emphasize how each approach can be productively used to address the goals of the other. The book seeks to contribute to a mutually beneficial and more productive discipline, and overall, it succeeds in this effort.

  8. Bibliometric Perspectives on Medical Innovation using the Medical Subject Headings (MeSH) of PubMed

    E-print Network

    Leydesdorff, Loet; Rafols, Ismael

    2012-01-01

    Multiple perspectives on the nonlinear processes of medical innovations can be distinguished and combined using the Medical Subject Headings (MeSH) of the Medline database. Focusing on three main branches-"diseases," "drugs and chemicals," and "techniques and equipment"-we use base maps and overlay techniques to investigate the translations and interactions and thus to gain a bibliometric perspective on the dynamics of medical innovations. To this end, we first analyze the Medline database, the MeSH index tree, and the various options for a static mapping from different perspectives and at different levels of aggregation. Following a specific innovation (RNA interference) over time, the notion of a trajectory which leaves a signature in the database is elaborated. Can the detailed index terms describing the dynamics of research be used to predict the diffusion dynamics of research results? Possibilities are specified for further integration between the Medline database, on the one hand, and the Science Citati...

  9. Celebrating methodological challenges and changes: reflecting on the emergence and importance of the role of qualitative evidence in Cochrane reviews

    PubMed Central

    2013-01-01

    Cochrane systematic reviews have proven to be beneficial for decision making processes, both on a practitioner and a policy level, and there are current initiatives to extend the types of evidence used by them, including qualitative research. In this article we outline the major achievements of the Cochrane Qualitative and Implementation Methods Group. Although the Group has encountered numerous challenges in dealing with the evolution of qualitative evidence synthesis, both outside and within the Cochrane Collaboration, it has successfully responded to the challenges posed in terms of incorporating qualitative evidence in systematic reviews. The Methods Group will continue to advocate for more flexible and inclusive approaches to evidence synthesis in order to meet the exciting challenges and opportunities presented by mixed methods systematic reviews and reviews of complex interventions. PMID:24135194

  10. Finding Answers in a Beauty Shop | NIH MedlinePlus the Magazine

    MedlinePLUS

    ... customers the MedlinePlus website. Dexter Waiters uses the computer at MaFlo's to access the MedlinePlus consumer health ... A waiting area offers several comfortable chairs, three computers, and a printer. On a typical day, the ...

  11. MedlinePlus FAQ: Can I play videos on my mobile device?

    MedlinePLUS

    ... Videos & Cool Tools ESPAÑOL Question: Can I play videos on my mobile device? To use the sharing ... this page, please enable JavaScript. Answer: MedlinePlus has video content in different formats. MedlinePlus also links to ...

  12. Seasonal Allergy Research at NIH | NIH MedlinePlus the Magazine

    MedlinePLUS

    ... this page please turn Javascript on. Feature: Managing Allergies Seasonal Allergy Research at NIH Past Issues / Spring 2013 Table of Contents To Find Out More MedlinePlus: Allergy www.nlm.nih.gov/medlineplus/allergy.html MedlinePlus: ...

  13. Mining locus tags in PubMed Central to improve microbial gene annotation

    PubMed Central

    2014-01-01

    Background The scientific literature contains millions of microbial gene identifiers within the full text and tables, but these annotations rarely get incorporated into public sequence databases. We propose to utilize the Open Access (OA) subset of PubMed Central (PMC) as a gene annotation database and have developed an R package called pmcXML to automatically mine and extract locus tags from full text, tables and supplements. Results We mined locus tags from 1835 OA publications in ten microbial genomes and extracted tags mentioned in 30,891 sentences in main text and 20,489 rows in tables. We identified locus tag pairs marking the start and end of a region such as an operon or genomic island and expanded these ranges to add another 13,043 tags. We also searched for locus tags in supplementary tables and publications outside the OA subset in Burkholderia pseudomallei K96243 for comparison. There were 168 publications containing 48,470 locus tags and 83% of mentions were from supplementary materials and 9% from publications outside the OA subset. Conclusions B. pseudomallei locus tags within the full text and tables of OA publications represent only a small fraction of the total mentions in the literature. For microbial genomes with very few functionally characterized proteins, the locus tags mentioned in supplementary tables and within ranges like genomic islands contain the majority of locus tags. Significantly, the functions in the R package provide access to additional resources in the OA subset that are not currently indexed or returned by searching PMC. PMID:24499370

  14. Systemic review on drug related hospital admissions – A pubmed based search

    PubMed Central

    Nivya, Kolli; Sri Sai Kiran, Vempati; Ragoo, Nandita; Jayaprakash, B.; Sonal Sekhar, M.

    2013-01-01

    Background Drug related admissions have significantly increased over the past few decades. According to various studies on drug related hospital admissions, it was estimated that around 5–10% of hospital admissions were due to drug related problems (DRP), in which 50% of them are avoidable. Objective The objective of the study was to derive results from various studies conducted on drug related hospital admissions and have an overall view about the incidence, frequency, cost of treatment, major causative drugs, problems for drug related hospital admissions, and preventable drug related admissions and summarize the factors responsible for the occurrence of DRP. Method Relevant literatures related to ‘drug related hospital admissions’ were obtained from PubMed database. Articles that were published from October 2007 to September 2012 were collected. All the studies being shown in the search results were considered for the study irrespective of the specialty department. Results A total of 366 articles were found based on the keyword ‘drug related hospital admission’, ‘drug related problem admission’, and ‘adverse drug event admissions’ search. Out of which 49 articles were identified to be showing relevance to the study. Non-English, abstract-only articles, and out-patient adverse drug reaction (ADR) studies were filtered from 49 articles. Finally 15 articles were taken up for the study. Systemic analysis was made on these articles and the results were summarized. Conclusion Most of DRP studies were retrospective, multicenter studies conducted in general populations in Europe. The main objective of the studies was to estimate DRP frequency, incidence, risk factors and trends of DRP hospital admissions. Anti-neoplastic agents, CVS drugs and CNS drugs were related to most of the drug related problems. These studies concluded polypharmacy and older age were the major risk factors for developing drug related problems. It was found that the cost for the management of DRP was directly proportional to severity. PMID:25685036

  15. Semi-automatic semantic annotation of PubMed Queries: a study on quality, efficiency, satisfaction

    PubMed Central

    Névéol, Aurélie; Islamaj-Do?an, Rezarta; Lu, Zhiyong

    2010-01-01

    Information processing algorithms require significant amounts of annotated data for training and testing. The availability of such data is often hindered by the complexity and high cost of production. In this paper, we investigate the benefits of a state-of-the-art tool to help with the semantic annotation of a large set of biomedical information queries. Seven annotators were recruited to annotate a set of 10,000 PubMed® queries with 16 biomedical and bibliographic categories. About half of the queries were annotated from scratch, while the other half were automatically pre-annotated and manually corrected. The impact of the automatic pre-annotations was assessed on several aspects of the task: time, number of actions, annotator satisfaction, inter-annotator agreement, quality and number of the resulting annotations. The analysis of annotation results showed that the number of required hand annotations is 28.9% less when using pre-annotated results from automatic tools. As a result, the overall annotation time was substantially lower when pre-annotations were used, while inter-annotator agreement was significantly higher. In addition, there was no statistically significant difference in the semantic distribution or number of annotations produced when pre-annotations were used. The annotated query corpus is freely available to the research community. This study shows that automatic pre-annotations are found helpful by most annotators. Our experience suggests using an automatic tool to assist large-scale manual annotation projects. This helps speed-up the annotation time and improve annotation consistency while maintaining high quality of the final annotations. PMID:21094696

  16. From patient uncertainty to WHO policy in two years: a GP's experience of preparing and maintaining a Cochrane review.

    PubMed

    Irving, Greg

    2014-03-01

    Clinical encounters in daily practice can provide a fertile ground for identifying uncertainties that require further investigation. Addressing such uncertainties by undertaking a Cochrane review can be a rewarding educational process and result in important contributions to health care policy. This paper describes the experiences of a UK GP undertaking a Cochrane review whilst working in clinical practice. It outlines some of the practical issues when starting a review, the importance of effective mentorship and collaboration, the power of the modern medical media (BMJ, Wikipedia) and engaging with policy makers (WHO). PMID:24195593

  17. TEXTQUEST: DOCUMENT CLUSTERING OF MEDLINE ABSTRACTS FOR CONCEPT DISCOVERY IN MOLECULAR

    E-print Network

    Poirazi, Yiota

    TEXTQUEST: DOCUMENT CLUSTERING OF MEDLINE ABSTRACTS FOR CONCEPT DISCOVERY IN MOLECULAR BIOLOGY I an algorithm for large-scale document clustering of biological text, obtained from Medline abstracts of sources [2, 3]. In the fields of Biology and Medicine, abstracts are collected and maintained in Medline

  18. On Combining Text and MeSH Searches to Improve the Retrieval of MEDLINE

    E-print Network

    Blott, Stephen

    . MEDLINE est le plus grand répertoire au monde de résumés biomédicaux. Il demeure le point de départ deOn Combining Text and MeSH Searches to Improve the Retrieval of MEDLINE documents Fabrice Camous'intégralité des articles sur le Web. Chaque entrée MEDLINE est indexée manuellement avec des termes MeSH et afin d

  19. MedKit: A Helper Toolkit for Automatic Mining of MEDLINE/PubMed Citations

    E-print Network

    Berleant, Daniel

    1 MedKit: A Helper Toolkit for Automatic Mining of MEDLINE/PubMed Citations Jing Ding Department of Electrical and Computer Engineering, Iowa State University, Ames, IA 50011, USA Running head: MEDLINE/PubMed Toolkit * To whom correspondence should be addressed #12;2 ABSTRACT Summary: MEDLINE/PubMed is one

  20. Identifying well-formed biomedical phrases in MEDLINE® text

    PubMed Central

    Kim, Won; Yeganova, Lana; Comeau, Donald C.; Wilbur, W. John

    2012-01-01

    In the modern world people frequently interact with retrieval systems to satisfy their information needs. Humanly understandable well-formed phrases represent a crucial interface between humans and the web, and the ability to index and search with such phrases is beneficial for human-web interactions. In this paper we consider the problem of identifying humanly understandable, well formed, and high quality biomedical phrases in MEDLINE documents. The main approaches used previously for detecting such phrases are syntactic, statistical, and a hybrid approach combining these two. In this paper we propose a supervised learning approach for identifying high quality phrases. First we obtain a set of known well-formed useful phrases from an existing source and label these phrases as positive. We then extract from MEDLINE a large set of multiword strings that do not contain stop words or punctuation. We believe this unlabeled set contains many well-formed phrases. Our goal is to identify these additional high quality phrases. We examine various feature combinations and several machine learning strategies designed to solve this problem. A proper choice of machine learning methods and features identifies in the large collection strings that are likely to be high quality phrases. We evaluate our approach by making human judgments on multiword strings extracted from MEDLINE using our methods. We find that over 85% of such extracted phrase candidates are humanly judged to be of high quality. PMID:22683889

  1. Using Cochran's Z Statistic to Test the Kernel-Smoothed Item Response Function Differences between Focal and Reference Groups

    ERIC Educational Resources Information Center

    Zheng, Yinggan; Gierl, Mark J.; Cui, Ying

    2010-01-01

    This study combined the kernel smoothing procedure and a nonparametric differential item functioning statistic--Cochran's Z--to statistically test the difference between the kernel-smoothed item response functions for reference and focal groups. Simulation studies were conducted to investigate the Type I error and power of the proposed…

  2. The dose–response characteristics of inhaled corticosteroids when used to treat asthma: An overview of Cochrane systematic reviews

    Microsoft Academic Search

    N. P. Adams; P. W. Jones

    2006-01-01

    Summary Inhaled corticosteroids form the cornerstone of treatment for most patients with asthma. A range of compounds are available with a wide range of prescribable doses. In this overview, we summarize the findings from a number of Cochrane systematic reviews that have examined the relative benefits of different doses of beclometasone dipropionate, budesonide and fluticasone propionate when used to treat

  3. Per Reinhall Some Recent Publications Grande KJ, Cochran RP, Reinhall PG, Kunzelman KS, "Mechanisms of Aortic Valve

    E-print Network

    Hochberg, Michael

    and Cardiovascular Surgery, 119(4 ):75363, 2000 Storti DW, Reinhall PG," PhaseLocked Mode Stability for Coupled of Marfan Syndrome, Journal of Thoracic and Cardiovascular Surgery, 2001, 122(5), 946954 Huang YH of Thoracic Surgery, Vol. 69 (6):18511857, 2000 Grande KJ, Cochran RP, Reinhall PG, Verrier ED

  4. Outcomes in Cochrane Systematic Reviews Addressing Four Common Eye Conditions: An Evaluation of Completeness and Comparability

    PubMed Central

    Saldanha, Ian J.; Dickersin, Kay; Wang, Xue; Li, Tianjing

    2014-01-01

    Introduction Choice of outcomes is critical for clinical trialists and systematic reviewers. It is currently unclear how systematic reviewers choose and pre-specify outcomes for systematic reviews. Our objective was to assess the completeness of pre-specification and comparability of outcomes in all Cochrane reviews addressing four common eye conditions. Methods We examined protocols for all Cochrane reviews as of June 2013 that addressed glaucoma, cataract, age-related macular degeneration (AMD), and diabetic retinopathy (DR). We assessed completeness and comparability for each outcome that was named in ?25% of protocols on those topics. We defined a completely-specified outcome as including information about five elements: domain, specific measurement, specific metric, method of aggregation, and time-points. For each domain, we assessed comparability in how individual elements were specified across protocols. Results We identified 57 protocols addressing glaucoma (22), cataract (16), AMD (15), and DR (4). We assessed completeness and comparability for five outcome domains: quality-of-life, visual acuity, intraocular pressure, disease progression, and contrast sensitivity. Overall, these five outcome domains appeared 145 times (instances). Only 15/145 instances (10.3%) were completely specified (all five elements) (median?=?three elements per outcome). Primary outcomes were more completely specified than non-primary (median?=?four versus two elements). Quality-of-life was least completely specified (median?=?one element). Due to largely incomplete outcome pre-specification, conclusive assessment of comparability in outcome usage across the various protocols per condition was not possible. Discussion Outcome pre-specification was largely incomplete; we encourage systematic reviewers to consider all five elements. This will indicate the importance of complete specification to clinical trialists, on whose work systematic reviewers depend, and will indirectly encourage comparable outcome choice to reviewers undertaking related research questions. Complete pre-specification could improve efficiency and reduce bias in data abstraction and analysis during a systematic review. Ultimately, more completely specified and comparable outcomes could make systematic reviews more useful to decision-makers. PMID:25329377

  5. Lifestyle factors in hypertension drug research: systematic analysis of articles in a leading cochrane report.

    PubMed

    Wilson, Dan E; Van Vlack, Tashina; Schievink, Brendin P; Doak, Eric B; Shane, Jason S; Dean, Elizabeth

    2014-01-01

    Established standards for first-line hypertension management include lifestyle modification and behavior change. The degree to which and how lifestyle modification is systematically integrated into studies of first-line drug management for hypertension is of methodological and clinical relevance. This study systematically reviewed the methodology of articles from a recent Cochrane review that had been designed to inform first-line medical treatment of hypertension and was representative of high quality established clinical trials in the field. Source articles (n = 34) were systematically reviewed for lifestyle interventions including smoking cessation, diet, weight loss, physical activity and exercise, stress reduction, and moderate alcohol consumption. 54% of articles did not mention lifestyle modification; 46% contained nonspecific descriptions of interventions. We contend that hypertension management research trials (including drug studies) need to elucidate the benefits and risks of drug-lifestyle interaction, to support the priority of lifestyle modification, and that lifestyle modification, rather than drugs, is seen by patients and the public as a priority for health professionals. The inclusion of lifestyle modification strategies in research designs for hypertension drug trials could enhance current research, from trial efficacy to clinical outcome effectiveness, and align hypertension best practices of a range of health professionals with evidence-based knowledge translation. PMID:24678418

  6. Cochrane corner: is integrated disease management for patients with COPD effective?

    PubMed

    Kruis, Annemarije L; Smidt, Nynke; Assendelft, Willem J J; Gussekloo, Jacobijn; Boland, Melinde R S; Rutten-van Mölken, Maureen; Chavannes, Niels H

    2014-11-01

    Patients with COPD experience respiratory symptoms, impairments of daily living and recurrent exacerbations. The aim of integrated disease management (IDM) is to establish a programme of different components of care (ie, self-management, exercise, nutrition) in which several healthcare providers (ie, nurses, general practitioners, physiotherapists, pulmonologists) collaborate to provide efficient and good quality of care. The aim of this Cochrane systematic review was to evaluate the effectiveness of IDM on quality of life, exercise tolerance and exacerbation related outcomes. Searches for all available evidence were carried out in various databases. Included randomised controlled trials (RCTs) consisted of interventions with multidisciplinary (?2 healthcare providers) and multitreatment (?2 components) IDM interventions with duration of at least 3?months. Two reviewers independently searched, assessed and extracted data of all RCTs. A total of 26 RCTs were included, involving 2997 patients from 11 different countries with a follow-up varying from 3 to 24?months. In all 68% of the patients were men, with a mean age of 68?years and a mean forced expiratory volume in 1?s (FEV1) predicted value of 44.3%. Patients treated with an IDM programme improved significantly on quality of life scores and reported a clinically relevant improvement of 44?m on 6?min walking distance, compared to controls. Furthermore, the number of patients with ?1 respiratory related hospital admission reduced from 27 to 20 per 100 patients. Duration of hospitalisation decreased significantly by nearly 4?days. PMID:24415716

  7. Creating an Online Dictionary of Abbreviations from MEDLINE

    PubMed Central

    Chang, Jeffrey T.; Schütze, Hinrich; Altman, Russ B.

    2002-01-01

    Objective. The growth of the biomedical literature presents special challenges for both human readers and automatic algorithms. One such challenge derives from the common and uncontrolled use of abbreviations in the literature. Each additional abbreviation increases the effective size of the vocabulary for a field. Therefore, to create an automatically generated and maintained lexicon of abbreviations, we have developed an algorithm to match abbreviations in text with their expansions. Design. Our method uses a statistical learning algorithm, logistic regression, to score abbreviation expansions based on their resemblance to a training set of human-annotated abbreviations. We applied it to Medstract, a corpus of MEDLINE abstracts in which abbreviations and their expansions have been manually annotated. We then ran the algorithm on all abstracts in MEDLINE, creating a dictionary of biomedical abbreviations. To test the coverage of the database, we used an independently created list of abbreviations from the China Medical Tribune. Measurements. We measured the recall and precision of the algorithm in identifying abbreviations from the Medstract corpus. We also measured the recall when searching for abbreviations from the China Medical Tribune against the database. Results. On the Medstract corpus, our algorithm achieves up to 83% recall at 80% precision. Applying the algorithm to all of MEDLINE yielded a database of 781,632 high-scoring abbreviations. Of all the abbreviations in the list from the China Medical Tribune, 88% were in the database. Conclusion. We have developed an algorithm to identify abbreviations from text. We are making this available as a public abbreviation server at \\url{http://abbreviation.stanford.edu/}. PMID:12386112

  8. The Use of Transarterial Chemoembolization in the Treatment of Unresectable Hepatocellular Carcinoma: A Response to the Cochrane Collaboration Review of 2011

    PubMed Central

    Ray, Charles E.; Haskal, Ziv J; Geschwind, Jean-Francois H.; Funaki, Brian S.

    2015-01-01

    This commentary is written in response to a recent Cochrane Collaboration review published in March 2011 (1). The authors of this commentary would like to express their concerns over the conclusions of the Cochrane review, which state, “There is no firm evidence to support or refute transarterial chemoembolization (TACE) or transarterial embolization (TAE) for patients with unresectable hepatocellular carcinoma (HCC).” PMID:22035882

  9. Distribution of Country of Origin in Studies Used in Cochrane Reviews

    PubMed Central

    Wolff, Robert F.; Reinders, Stefan; Barth, Michael; Antes, Gerd

    2011-01-01

    Background and Objective Inclusion in systematic reviews is one important component in judging the potential impact of clinical studies upon practice and hence the ‘value for money’ of spending for clinical research. This study aims to quantify the distribution of countries of origin of clinical studies used in Cochrane Reviews (CRs), and to link these data to the size of a country and to its spending on research. Methods Random sample of publications used for CRs published in Issue 1 2008 and of publications used in CRs in the field of complementary and alternative medicine (CAM). Publications without original data were excluded. Likely countries of origin determined based on abstracts/full texts. CIA World Factbook (population data) and OECD database (economic data) were used. Results 1,000 random entries out of 140,005 references available in all specialities. In 876 (91.4%) of 959 eligible studies, country of origin was determined. The USA was the leading contributor (36.0% of the studies), followed by UK (13.4%), Canada (5.3%), Australia and Sweden (3.7%). In the CAM sample, country of origin was determined in 458 (93.5%) of 497 assessed studies. Again, the USA was the leading contributor (24.9%), with China also emerging as a significant contributor (24.7%) in this field. For both samples, the contribution of smaller countries (especially Scandinavian countries, Greece, and Ireland) became more noteworthy when considered in relation to population size and research spending. Conclusions Our results support the leading roles of both the USA and the UK in publishing clinical papers. The emerging role of China can be seen, particularly related to CAM studies. Taking into account size of population and economic power, countries like France, Germany, Italy, and Spain provide small contributions. In contrast, smaller countries like Australia, Denmark, Finland, Ireland, New Zealand, and Sweden also play major roles. PMID:21526195

  10. Automated Patent Categorization and Guided Patent Search using IPC as Inspired by MeSH and PubMed

    PubMed Central

    2013-01-01

    Document search on PubMed, the pre-eminent database for biomedical literature, relies on the annotation of its documents with relevant terms from the Medical Subject Headings ontology (MeSH) for improving recall through query expansion. Patent documents are another important information source, though they are considerably less accessible. One option to expand patent search beyond pure keywords is the inclusion of classification information: Since every patent is assigned at least one class code, it should be possible for these assignments to be automatically used in a similar way as the MeSH annotations in PubMed. In order to develop a system for this task, it is necessary to have a good understanding of the properties of both classification systems. This report describes our comparative analysis of MeSH and the main patent classification system, the International Patent Classification (IPC). We investigate the hierarchical structures as well as the properties of the terms/classes respectively, and we compare the assignment of IPC codes to patents with the annotation of PubMed documents with MeSH terms. Our analysis shows a strong structural similarity of the hierarchies, but significant differences of terms and annotations. The low number of IPC class assignments and the lack of occurrences of class labels in patent texts imply that current patent search is severely limited. To overcome these limits, we evaluate a method for the automated assignment of additional classes to patent documents, and we propose a system for guided patent search based on the use of class co-occurrence information and external resources. PMID:23734562

  11. A qualitative study into the difficulties experienced by healthcare decision makers when reading a Cochrane diagnostic test accuracy review

    PubMed Central

    2013-01-01

    Background Cochrane reviews are one of the best known and most trusted sources of evidence-based information in health care. While steps have been taken to make Cochrane intervention reviews accessible to a diverse readership, little is known about the accessibility of the newcomer to the Cochrane library: diagnostic test accuracy reviews (DTARs). The current qualitative study explored how healthcare decision makers, who varied in their knowledge and experience with test accuracy research and systematic reviews, read and made sense of DTARs. Methods A purposive sample of clinicians, researchers and policy makers (n = 21) took part in a series of think-aloud interviews, using as interview material the first three DTARs published in the Cochrane library. Thematic qualitative analysis of the transcripts was carried out to identify patterns in participants’ ‘reading’ and interpretation of the reviews and the difficulties they encountered. Results Participants unfamiliar with the design and methodology of DTARs found the reviews largely inaccessible and experienced a range of difficulties stemming mainly from the mismatch between background knowledge and level of explanation provided in the text. Experience with systematic reviews of interventions did not guarantee better understanding and, in some cases, led to confusion and misinterpretation. These difficulties were further exacerbated by poor layout and presentation, which affected even those with relatively good knowledge of DTARs and had a negative impact not only on their understanding of the reviews but also on their motivation to engage with the text. Comparison between the readings of the three reviews showed that more accessible presentation, such as presenting the results as natural frequencies, significantly increased participants’ understanding. Conclusions The study demonstrates that authors and editors should pay more attention to the presentation as well as the content of Cochrane DTARs, especially if the reports are aimed at readers with various levels of background knowledge and experience. It also raises the question as to the anticipated target audience of the reports and suggests that different groups of healthcare decision-makers may require different modes of presentation. PMID:23680077

  12. MedlinePlus 2012 User Survey Results: What is your preferred reading language on the Web? (Los usuarios de MedlinePlus ....

    MedlinePLUS

    ... Index | Previous | Next What is your preferred reading language on the Web? (MedlinePlus en español users ... National Library of Medicine 8600 Rockville Pike, Bethesda, MD 20894 U.S. Department ...

  13. Do Surgical Patients Benefit from Perioperative Gabapentin\\/Pregabalin? A Systematic Review of Efficacy and Safety

    Microsoft Academic Search

    Elina M. Tiippana; Katri Hamunen; Vesa K. Kontinen; Eija Kalso

    2007-01-01

    BACKGROUND: Gabapentin and pregabalin have antiallodynic and antihyperalgesic properties useful for treating neuropathic pain. These properties may also be beneficial in acute postoperative pain. In this study we evaluated randomized, controlled trials examining the analgesic efficacy, adverse effects, and clinical value of gabapentinoids in postoperative pain. METHODS: A systematic search of Medline, PubMed, and Cochrane Central Register of Controlled Trials

  14. The Relationship between Sugar-Containing Methadone and Dental Caries: A Systematic Review

    ERIC Educational Resources Information Center

    Tripathee, Sheela; Akbar, Tahira; Richards, Derek; Themessl-Huber, Markus; Freeman, Ruth

    2013-01-01

    Objectives: To review the evidence of a relationship between sugar-containing methadone and dental caries. Data sources: A systematic search of Cochrane Library, PubMed, PsychINFO, EMBASE, MEDLINE, Current Controlled Trials, WHO, OHRN, SIGLE and ERIC databases was conducted from January 1978 up to June 2010. Study selection: Articles were assessed…

  15. Relationship Between the Use of Asthma Action Plans and Asthma Exacerbations in Children With AsthmaA Systematic Review

    Microsoft Academic Search

    Karen R. Kessler

    2011-01-01

    The purpose of this integrative review is to describe and assess current research findings and summarize the relationship between action plans and asthma exacerbations in children with asthma. Medline, CINAHL Plus with full text, PubMed, and Cochrane Library databases were searched as well as bibliographies of included studies. Three hundred eighty-five studies were identified. Thirteen studies were identified meeting inclusion

  16. Association between Clomiphene Citrate and Visual Disturbances with Special Emphasis on Central Retinal Vein Occlusion: A Review

    Microsoft Academic Search

    Maria I. Viola; David Meyer; Thinus Kruger

    2011-01-01

    Objectives: To determine whether clomiphene citrate (CC) can be implicated as a cause for central retinal vein occlusion (CRVO) and other visual disturbances. Methods: For this systematic review, we performed a search of the following databases: PubMed (1976 to November 2009), Medline Plus 2009, Cochrane Library (1996 to November 2009), Google and Google Scholar (1996 to November 2009). Thirty-five relevant

  17. Physical Activity Measurement Instruments for Children with Cerebral Palsy: A Systematic Review

    ERIC Educational Resources Information Center

    Capio, Catherine M.; Sit, Cindy H. P.; Abernethy, Bruce; Rotor, Esmerita R.

    2010-01-01

    Aim: This paper is a systematic review of physical activity measurement instruments for field-based studies involving children with cerebral palsy (CP). Method: Database searches using PubMed Central, MEDLINE, CINAHL Plus, PsycINFO, EMBASE, Cochrane Library, and PEDro located 12 research papers, identifying seven instruments that met the inclusion…

  18. Early Childhood Dental Caries: A Rising Dental Public Health Crisis

    ERIC Educational Resources Information Center

    Gomez, Grace Felix

    2013-01-01

    The aim of this article is to examine the literature and review the risk factors and disparities contributing to early childhood caries (ECC), which is a major health problem among preschoolers in the United States of America. A search was conducted using MEDLINE, PubMed, Google Scholar, and the Cochrane Library databases and the key terms…

  19. More to Love on MedlinePlus® Mobile: A Full Version for Your Phone

    MedlinePLUS

    ... remove the need for a separate mobile site. Users will then have one destination for MedlinePlus ( medlineplus.gov ) when using any device. Until then, try out this first offering of MedlinePlus's responsive design on your smartphone at http://m.medlineplus.gov . Mobile version Get ...

  20. Trusted Health Information for the Public | NIH MedlinePlus the Magazine

    MedlinePLUS

    ... enabled phones at m.medlineplus.gov and, in Spanish, at m.medlineplus.gov/spanish . MedlinePlus.gov: just a click away For over ... and is available anytime, anywhere for free. A Spanish-language version, MedlinePlus en español ( medlineplus.gov/spanish ), ...

  1. Online Medline plus Fan Search V Offsearch: A Comparison of Literature Retrieval Methods

    Microsoft Academic Search

    Dennis F. Thompson; Mary Lee

    1986-01-01

    Medline is a computerized indexing and abstracting service for biomedical literature and is one of the most commonly used methods of literature retrieval. An alternative manual technique is fan searching. Fan searching involves scanning bibliographies of relevant articles from online Medline searches of the most current literature. We compared the amount of relevant literature retrieval between these two methods. We

  2. User experiences of evidence-based online resources for health professionals: User testing of The Cochrane Library

    PubMed Central

    Rosenbaum, Sarah E; Glenton, Claire; Cracknell, Jane

    2008-01-01

    Background Evidence-based decision making relies on easy access to trustworthy research results. The Cochrane Library is a key source of evidence about the effect of interventions and aims to "promote the accessibility of systematic reviews to anyone wanting to make a decision about health care". We explored how health professionals found, used and experienced The Library, looking at facets of user experience including findability, usability, usefulness, credibility, desirability and value. Methods We carried out 32 one-hour usability tests on participants from Norway and the UK. Participants both browsed freely and attempted to perform individually tailored tasks while "thinking aloud". Sessions were recorded and viewed in real time by researchers. Transcriptions and videos were reviewed by one researcher and one designer. Findings reported here reflect issues receiving a high degree of saturation and that we judge to be critical to the user experience of evidence-based web sites, based on principles for usability heuristics, web guidelines and evidence-based practice. Results Participants had much difficulty locating both the site and its contents. Non-native English speakers were at an extra disadvantage when retrieving relevant documents despite high levels of English-language skills. Many participants displayed feelings of ineptitude, alienation and frustration. Some made serious mistakes in correctly distinguishing between different information types, for instance reviews, review protocols, and individual studies. Although most expressed a high regard for the site's credibility, some later displayed a mistrust of the independence of the information. Others were overconfident, thinking everything on The Cochrane Library site shared the same level of quality approval. Conclusion Paradoxically, The Cochrane Library, established to support easy access to research evidence, has its own problems of accessibility. Health professionals' experiences of this and other evidence-based online resources can be improved by applying existing principles for web usability, prioritizing the development of simple search functionality, emitting "researcher" jargon, consistent marking of site ownership, and clear signposting of different document types and different content quality. PMID:18662382

  3. What efficacy measures are clinically relevant and should be used in Cochrane reviews of acute migraine trials? An alternative viewpoint.

    PubMed

    Steiner, T J

    2015-04-01

    I briefly review the purposes of efficacy measures, which go far beyond supporting new drug development. I use vignettes to illustrate the importance of functional recovery during the migraine attack, and argue that headache relief provides this. Sustained headache relief (SHR) is therefore a very worthwhile outcome when the alternative is a day of debilitating pain. As a measure, SHR may not be ideal for new drug development but it is informative to individuals, health care providers and politicians, and serves cost-effectiveness analysis better than any other. Cochrane are absolutely right to use it in systematic reviews along with the IHS-recommended measures. PMID:25212468

  4. ALICE: An Algorithm to Extract Abbreviations from MEDLINE

    PubMed Central

    Ao, Hiroko; Takagi, Toshihisa

    2005-01-01

    Objective: To help biomedical researchers recognize dynamically introduced abbreviations in biomedical literature, such as gene and protein names, we have constructed a support system called ALICE (Abbreviation LIfter using Corpus-based Extraction). ALICE aims to extract all types of abbreviations with their expansions from a target paper on the fly. Methods: ALICE extracts an abbreviation and its expansion from the literature by using heuristic pattern-matching rules. This system consists of three phases and potentially identifies valid 320 abbreviation-expansion patterns as combinations of the rules. Results: It achieved 95% recall and 97% precision on randomly selected titles and abstracts from the MEDLINE database. Conclusion: ALICE extracted abbreviations and their expansions from the literature efficiently. The subtly compiled heuristics enabled it to extract abbreviations with high recall without significantly reducing precision. ALICE does not only facilitate recognition of an undefined abbreviation in a paper by constructing an abbreviation database or dictionary, but also makes biomedical literature retrieval more accurate. This system is freely available at http://uvdb3.hgc.jp/ALICE/ALICE_index.html. PMID:15905486

  5. The effect of feature representation on MEDLINE document classification.

    PubMed

    Yetisgen-Yildiz, Meliha; Pratt, Wanda

    2005-01-01

    This work explores the effect of text representation techniques on the overall performance of medical text classification. To accomplish this goal, we developed a text classification system that supports the very basic word representation (bag-of-words) and the more complex medical phrase representation (bag-of-phrases). We also combined word and phrase representations (hybrid) for further analysis. Our system extracts medical phrases from text by incorporating a medical knowledge base and natural language processing techniques. We conducted experiments to evaluate the effects of different representations by measuring the change in classification performance with MEDLINE documents from the OHSUMED dataset. We measured classification performance with information retrieval metrics; precision (p), recall (r), and F1-score (F1). In our experiments, we achieved better classification performance with the hybrid approach (p=0.87, r=0.46, F1=0.60) compared to the bag-of-words approach (p=0.85, r=0.44, F1=0.58) and the bag-of-phrases approach (p=0.87, r=0.42, F1=0.57). PMID:16779160

  6. Bibliometric analysis of the Korean Journal of Parasitology: measured from SCI, PubMed, Scopus, and Synapse databases.

    PubMed

    Lee, Choon Shil

    2009-10-01

    The Korean Journal of Parasitology (KJP) is the official journal of the Korean Society for Parasitology which is celebrating its 50th anniversary in 2009. To assess the contributions and achievements of the KJP, bibliometric analysis was conducted based on the citation data retrieved from 4 major databases; SCI, PubMed, Synapse, and Scopus. It was found that the KJP articles were constantly cited by the articles published in major international journals represented in these databases. More than 60% of 1,370 articles published in the KJP from 1963 to June 2009 were cited at least once by SCI articles. The overall average times cited by SCI articles are 2.6. The rate is almost 3 times higher for the articles published in the last 10 years compared to 1.0 for the articles of the 1960s. The SCI journal impact factor for 2008 is calculated as 0.871. It is increasing and it is expected to increase further with the introduction of the KJP in the database in 2008. The more realistic h-indices were measured from the study data set covering all the citations to the KJP; 17 for SCI, 6 for PubMed, 19 for Synapse, and 17 for Scopus. Synapse extensively picked up the citations to the earlier papers not retrievable from the other 3 databases. It identified many papers published in the 1960s and in the 1980s which have been cited heavily, proving the central role of the KJP in the dissemination of the important research findings over the last 5 decades. PMID:19885331

  7. A Re-Analysis of the Cochrane Library Data: The Dangers of Unobserved Heterogeneity in Meta-Analyses

    PubMed Central

    Kontopantelis, Evangelos; Springate, David A.; Reeves, David

    2013-01-01

    Background Heterogeneity has a key role in meta-analysis methods and can greatly affect conclusions. However, true levels of heterogeneity are unknown and often researchers assume homogeneity. We aim to: a) investigate the prevalence of unobserved heterogeneity and the validity of the assumption of homogeneity; b) assess the performance of various meta-analysis methods; c) apply the findings to published meta-analyses. Methods and Findings We accessed 57,397 meta-analyses, available in the Cochrane Library in August 2012. Using simulated data we assessed the performance of various meta-analysis methods in different scenarios. The prevalence of a zero heterogeneity estimate in the simulated scenarios was compared with that in the Cochrane data, to estimate the degree of unobserved heterogeneity in the latter. We re-analysed all meta-analyses using all methods and assessed the sensitivity of the statistical conclusions. Levels of unobserved heterogeneity in the Cochrane data appeared to be high, especially for small meta-analyses. A bootstrapped version of the DerSimonian-Laird approach performed best in both detecting heterogeneity and in returning more accurate overall effect estimates. Re-analysing all meta-analyses with this new method we found that in cases where heterogeneity had originally been detected but ignored, 17–20% of the statistical conclusions changed. Rates were much lower where the original analysis did not detect heterogeneity or took it into account, between 1% and 3%. Conclusions When evidence for heterogeneity is lacking, standard practice is to assume homogeneity and apply a simpler fixed-effect meta-analysis. We find that assuming homogeneity often results in a misleading analysis, since heterogeneity is very likely present but undetected. Our new method represents a small improvement but the problem largely remains, especially for very small meta-analyses. One solution is to test the sensitivity of the meta-analysis conclusions to assumed moderate and large degrees of heterogeneity. Equally, whenever heterogeneity is detected, it should not be ignored. PMID:23922860

  8. bookmark.php?pub=medlineplus&title=MedlinePlus: Trusted Health Information for You&lng=en

    MedlinePLUS

    #footer {position: relative;} #footer-inner{background:#fff;} Bookmark & Share medlineplus MedlinePlus: Trusted Health Information for You 100zakladok 2 Tag 2linkme A97abi Adfty Adifni ADV QR code Amazon Amen Me! ...

  9. Using Co-Authoring and Cross-Referencing Information for MEDLINE Indexing

    E-print Network

    Zweigenbaum, Pierre

    referencing and au- thoring links can be used for this purpose. Using a JAMA-based subset of MEDLINE, we from the Journal of the American Medical Associ- ation (JAMA, http://jama.ama-assn.org/), downloading

  10. Globetrotting to a Good Night's Sleep | NIH MedlinePlus the Magazine

    MedlinePLUS

    ... is one of the most common and troubling sleep disorders. At least 1 in 10 older adults, and ... have sleep apnea. To Find Out More MedlinePlus Sleep Disorders www.nlm.nih.gov/medlineplus/sleepdisorders.html NHLBI ...

  11. MedlinePlus Connect: Linking Patient Portals and Electronic Health Records to Health Information

    MedlinePLUS

    ... of the criteria for Meaningful Use of Health Information Technology. You don't have to use MedlinePlus Connect exclusively to link to patient education information. Many EHR systems can be configured to link ...

  12. Finding Good Health Information on the Internet | NIH MedlinePlus the Magazine

    MedlinePLUS

    ... MedlinePlus Advantage Finding Good Health Information on the Internet Winter 2015 Table of Contents Millions of consumers get health information from magazines, TV, or the Internet. Some is reliable and up to date, some ...

  13. To Compare PubMed Clinical Queries and UpToDate in Teaching Information Mastery to Clinical Residents: A Crossover Randomized Controlled Trial

    PubMed Central

    Sayyah Ensan, Ladan; Faghankhani, Masoomeh; Javanbakht, Anna; Ahmadi, Seyed-Foad; Baradaran, Hamid Reza

    2011-01-01

    Purpose To compare PubMed Clinical Queries and UpToDate regarding the amount and speed of information retrieval and users' satisfaction. Method A cross-over randomized trial was conducted in February 2009 in Tehran University of Medical Sciences that included 44 year-one or two residents who participated in an information mastery workshop. A one-hour lecture on the principles of information mastery was organized followed by self learning slide shows before using each database. Subsequently, participants were randomly assigned to answer 2 clinical scenarios using either UpToDate or PubMed Clinical Queries then crossed to use the other database to answer 2 different clinical scenarios. The proportion of relevantly answered clinical scenarios, time to answer retrieval, and users' satisfaction were measured in each database. Results Based on intention-to-treat analysis, participants retrieved the answer of 67 (76%) questions using UpToDate and 38 (43%) questions using PubMed Clinical Queries (P<0.001). The median time to answer retrieval was 17 min (95% CI: 16 to 18) using UpToDate compared to 29 min (95% CI: 26 to 32) using PubMed Clinical Queries (P<0.001). The satisfaction with the accuracy of retrieved answers, interaction with UpToDate and also overall satisfaction were higher among UpToDate users compared to PubMed Clinical Queries users (P<0.001). Conclusions For first time users, using UpToDate compared to Pubmed Clinical Querries can lead to not only a higher proportion of relevant answer retrieval within a shorter time, but also a higher users' satisfaction. So, addition of tutoring pre-appraised sources such as UpToDate to the information mastery curricula seems to be highly efficient. PMID:21858142

  14. Computerized transcription of searches from MEDLINE to an information manager package, SCI-MATE.

    PubMed

    Siu, T O; Nguyen, S

    1989-12-01

    MEDLINE bibliographic files, or searches from MEDLINE, can now be downloaded to personal computers. The materials can then be input to an information manager package, such as SCI-MATE, as a personal library for future updates, sorting, searching, cross-referencing, and reports. The transcription of the downloaded material to the manager package is tedious, however. A program has therefore been written to computerize the transcription. PMID:2686928

  15. Biotea: RDFizing PubMed Central in support for the paper as an interface to the Web of Data

    PubMed Central

    2013-01-01

    Background The World Wide Web has become a dissemination platform for scientific and non-scientific publications. However, most of the information remains locked up in discrete documents that are not always interconnected or machine-readable. The connectivity tissue provided by RDF technology has not yet been widely used to support the generation of self-describing, machine-readable documents. Results In this paper, we present our approach to the generation of self-describing machine-readable scholarly documents. We understand the scientific document as an entry point and interface to the Web of Data. We have semantically processed the full-text, open-access subset of PubMed Central. Our RDF model and resulting dataset make extensive use of existing ontologies and semantic enrichment services. We expose our model, services, prototype, and datasets at http://biotea.idiginfo.org/ Conclusions The semantic processing of biomedical literature presented in this paper embeds documents within the Web of Data and facilitates the execution of concept-based queries against the entire digital library. Our approach delivers a flexible and adaptable set of tools for metadata enrichment and semantic processing of biomedical documents. Our model delivers a semantically rich and highly interconnected dataset with self-describing content so that software can make effective use of it. PMID:23734622

  16. Tamm-Horsfall protein in patients with kidney dama...[Urol Res. 2004] -PubMed Result Urol Res. 2004 May;32(2):79-83. Links

    E-print Network

    Abraham, Nader G.

    Tamm-Horsfall protein in patients with kidney dama...[Urol Res. 2004] - PubMed Result Urol Res. 2004 May;32(2):79-83. Links Tamm-Horsfall protein in patients with kidney damage and diabetes in diabetic and control kidney tissue specimens with or without kidney damage. Immunogold labeling

  17. [Analysis of the Cochrane review: biomarkers as point-of-care tests to guide prescription of antibiotics in patients with acute respiratory infections in primary care. Cochrane Database Syst Rev. 2014,11:CD10130].

    PubMed

    Azevedo, Pedro; Costa, João; Vaz-Carneiro, António

    2014-01-01

    Acute respiratory infections are the most frequent reason for prescribing antibiotics in primary health care. Since most acute respiratory infections are of viral or non-severe bacterial etiology, the use of antibiotics is not beneficial and exposes patients to side effects. In addition, the undifferentiated prescription of this drug group increases antibiotic resistance and promotes: 1. increased costs for health systems; 2. failure to future treatments, increased morbidity and mortality from infectious diseases. In the appropriate clinical setting, the use of biomarkers as point-of-care tests to assess the acute phase response to injury of tissue / organ, is a strategy in the therapeutic management of patients with acute respiratory infections in outpatient context. This Cochrane review compared the prescription of antibiotics to acute respiratory infections based: 1. exclusively in the clinic; 2. Iinn the use of biomarkers as point-of-care tests (eg C-reactive protein). The C-reactive protein in quick test seems to be associated with reduced use of antibiotics, however, there has not been a reduction in the lenght of treatment or the perception of recovery by the patient. There may be an increase of hospitalizations compared with the group of patients without the biomarker use; no mortality was register in either group. PMID:25641279

  18. Pilot study optimizing MEDLINE queries in an automated disease management telemedicine system.

    PubMed Central

    Spaeder, Jeffrey A.

    2002-01-01

    Clinicians encounter many medical questions while providing outpatient medical care. A significant number of these questions can be answered using MEDLINE; however it has proven to be difficult to incorporate MEDLINE into routine clinical workflow and for clinicians to generate well constructed MEDLINE queries. This study however hypothesized that that well-constructed MEDLINE queries could be semi-automatically generated by an application named LitButton which was incorporated into the TeleWatch telemedicine system. The LitButton application was then prospectively evaluated in a pilot study by four nurse case managers (NCM) who monitored sixty-eight outpatients for three weeks. During this period the NCMs used the LitButton application sixteen times, and they subjectively reported in real-time that they obtained an answer in 56% of the cases, but that none of the successful information retrieval events resulted in a change in a patient's clinical management. The small number of LitButton events and lack of clinical impact was likely due to the fact that the LitButton function was designed to search MEDLINE for treatment related information; however the NCMs had limited medical decision making responsibilities. As a result there was a mismatch between the user's information needs and the system capabilities. PMID:12463918

  19. World Fisheries: A Social-Ecological Analysis, First Edition. Edited by Ommer, Perry, Cochrane and Cury. 2011 Blackwell Publishing Ltd. Published 2011 by Blackwell Publishing Ltd.

    E-print Network

    Paris-Sud XI, Université de

    World Fisheries: A Social-Ecological Analysis, First Edition. Edited by Ommer, Perry, Cochrane Advice for Fisheries Management in West Africa in the Context of Global Change Bora Masumbuko, Moctar Bâ advice on fisheries in West African countries. Based on a survey among researchers, experts, and managers

  20. Information Literacy for Users at the National Medical Library of Cuba: Cochrane Library Course for the Search of Best Evidence for Clinical Decisions

    ERIC Educational Resources Information Center

    Santana Arroyo, Sonia; del Carmen Gonzalez Rivero, Maria

    2012-01-01

    The National Medical Library of Cuba is currently developing an information literacy program to train users in the use of biomedical databases. This paper describes the experience with the course "Cochrane Library: Evidence-Based Medicine," which aims to teach users how to make the best use of this database, as well as the evidence-based medicine…

  1. Helping people make well-informed decisions about health care: old and new challenges to achieving the aim of the Cochrane Collaboration.

    PubMed

    Oxman, Andrew D

    2013-01-01

    The aim of the Cochrane Collaboration is to help people make well-informed decisions about health care by preparing, maintaining and promoting the accessibility of systematic reviews of the effects of health care interventions. This aim is as relevant now as it was 20 years ago, when the Cochrane Collaboration was established. Substantial progress has been made toward addressing challenges to achieving the Collaboration's aim. At the same time, a huge amount of work remains to be done. Current challenges include improving the quality of reviews, methodological challenges, meeting the needs of contributors and users and taking on new challenges while staying focused on the Collaboration's aim. Radical thinking and substantial change may be needed to identify and implement pragmatic strategies to ensure that reviews are up-to-date and informative. Methodological challenges include the development and application of better methods for addressing explanatory factors, incorporating non-randomized evidence and making comparisons across multiple interventions. Innovations in editorial processes and strategies to meet the needs of low- and middle-income countries and diverse users of Cochrane reviews are needed. Finally, although it is important to consider broadening the aims of the Collaboration to include types of questions other than the effects of interventions and types of products other than the Cochrane Library, we should not lose sight of the aim of the Cochrane Collaboration. Addressing that aim is still a major challenge that requires the collaboration of thousands of people around the world and continuing improvements in the methods used to achieve that aim. PMID:24050439

  2. The comparative recall of Google Scholar versus PubMed in identical searches for biomedical systematic reviews: a review of searches used in systematic reviews

    PubMed Central

    2013-01-01

    Background The usefulness of Google Scholar (GS) as a bibliographic database for biomedical systematic review (SR) searching is a subject of current interest and debate in research circles. Recent research has suggested GS might even be used alone in SR searching. This assertion is challenged here by testing whether GS can locate all studies included in 21 previously published SRs. Second, it examines the recall of GS, taking into account the maximum number of items that can be viewed, and tests whether more complete searches created by an information specialist will improve recall compared to the searches used in the 21 published SRs. Methods The authors identified 21 biomedical SRs that had used GS and PubMed as information sources and reported their use of identical, reproducible search strategies in both databases. These search strategies were rerun in GS and PubMed, and analyzed as to their coverage and recall. Efforts were made to improve searches that underperformed in each database. Results GS’ overall coverage was higher than PubMed (98% versus 91%) and overall recall is higher in GS: 80% of the references included in the 21 SRs were returned by the original searches in GS versus 68% in PubMed. Only 72% of the included references could be used as they were listed among the first 1,000 hits (the maximum number shown). Practical precision (the number of included references retrieved in the first 1,000, divided by 1,000) was on average 1.9%, which is only slightly lower than in other published SRs. Improving searches with the lowest recall resulted in an increase in recall from 48% to 66% in GS and, in PubMed, from 60% to 85%. Conclusions Although its coverage and precision are acceptable, GS, because of its incomplete recall, should not be used as a single source in SR searching. A specialized, curated medical database such as PubMed provides experienced searchers with tools and functionality that help improve recall, and numerous options in order to optimize precision. Searches for SRs should be performed by experienced searchers creating searches that maximize recall for as many databases as deemed necessary by the search expert. PMID:24360284

  3. A Study on the Selection and Utilization of MEDLINE Search Systems.

    ERIC Educational Resources Information Center

    Bader, Shelley A.; Piemme, Thomas E.

    This report presents the objectives, methodology, and results of a study which assessed the selection and utilization of four MEDLINE search systems by faculty and medical residents at the George Washington University Medical Center. The four systems, which were provided or sponsored by the Himmelfarb Health Sciences Library, offer a wide range of…

  4. Mining MEDLINE: Postulating a Beneficial Role for Curcumin Longa in Retinal Diseases

    E-print Network

    Srinivasan, Padmini

    Mining MEDLINE: Postulating a Beneficial Role for Curcumin Longa in Retinal Diseases Padmini supporting the suggested connection between curcumin and retinal diseases. In particular, curcumin influ, the evidence suggests that curcumin may have a beneficial and therapeutic role in the context of these dis

  5. Parkinson's Disease Research at NIH | NIH MedlinePlus the Magazine

    MedlinePLUS

    ... of this page please turn JavaScript on. Feature: Parkinson's Disease Parkinson's Disease Research at NIH Past Issues / Winter 2014 Table ... of its research: MedlinePlus . www.medlineplus.gov . Type "Parkinson's disease" in the Search box. NIHSeniorHealth —Parkinson's Disease http:// ...

  6. Married...with Food Allergies | NIH MedlinePlus the Magazine

    MedlinePLUS

    ... of this page please turn Javascript on. Feature: Food Allergies Married...with Food Allergies Past Issues / Spring 2011 Table of Contents ... married life together and a common problem—severe food allergies. NIH MedlinePlus magazine’s Naomi Miller caught up ...

  7. High school peer tutors teach MedlinePlus: a model for Hispanic outreach*

    PubMed Central

    Warner, Debra G.; Olney, Cynthia A.; Wood, Fred B.; Hansen, Lucille; Bowden, Virginia M.

    2005-01-01

    Objectives: The objective was to introduce the MedlinePlus Website to the predominantly Hispanic residents of the Lower Rio Grande Valley region of Texas by partnering with a health professions magnet high school (known as Med High). Methods: Community assessment was used in the planning stages and included pre-project focus groups with students and teachers. Outreach methods included peer tutor selection, train-the-trainer sessions, school and community outreach, and pre- and posttests of MedlinePlus training sessions. Evaluation methods included Web statistics; end-of-project interviews; focus groups with students, faculty, and librarians; and end-of-project surveys of students and faculty. Results: Four peer tutors reached more than 2,000 people during the project year. Students and faculty found MedlinePlus to be a useful resource. Faculty and librarians developed new or revised teaching methods incorporating MedlinePlus. The project enhanced the role of school librarians as agents of change at Med High. The project continues on a self-sustaining basis. Conclusions: Using peer tutors is an effective way to educate high school students about health information resources and, through the students, to reach families and community members. PMID:15858628

  8. 2 Winter 2007 NIH MedlinePlus NIH Director Elias A. Zerhouni, M.D., leads the NIH's 27 Insti-

    E-print Network

    Bandettini, Peter A.

    2 Winter 2007 NIH MedlinePlus NIH Director Elias A. Zerhouni, M.D., leads the NIH's 27 Insti- tutes; #12;NIH MedlinePlus Winter 2007 3 predictive about what happens to whom,and when,because we're dealing

  9. Analysis of the Acceptance Behaviour of Medical Librarians and Their Patrons with Regards to Medline on CD-ROM.

    ERIC Educational Resources Information Center

    Eger, A. J.

    1988-01-01

    Two questionnaires sent to medical librarians and users of the Core Medline/Ebsco CD-ROM disc in the Netherlands gathered data on librarians' attitudes toward the various forms in which Medline is offered--i.e., printed, online, and CD-ROM. Tables and graphs present data on product attributes, availability, use, relevance, subjects searched,…

  10. Can a core outcome set improve the quality of systematic reviews? – a survey of the Co-ordinating Editors of Cochrane review groups

    PubMed Central

    2013-01-01

    Background Missing outcome data or the inconsistent reporting of outcome data in clinical research can affect the quality of evidence within a systematic review. A potential solution is an agreed standardized set of outcomes known as a core outcome set (COS) to be measured in all studies for a specific condition. We investigated the amount of missing patient data for primary outcomes in Cochrane systematic reviews, and surveyed the Co-ordinating Editors of Cochrane Review Groups (CRGs) on issues related to the standardization of outcomes in their CRG’s reviews. These groups are responsible for the more than 7,000 protocols and full versions of Cochrane Reviews that are currently available, and the several hundred new reviews published each year, presenting the world’s largest collection of standardized systematic reviews in health care. Methods Using an unselected cohort of Cochrane Reviews, we calculated and presented the percentage of missing patient data for the primary outcome measure chosen for each review published by each CRG. We also surveyed the CRG Co-ordinating Editors to see what their policies are with regards to outcome selection and outcomes to include in the Summary of Finding (SoF) tables in their Cochrane Reviews. They were also asked to list the main advantages and challenges of standardizing outcomes across all reviews within their CRG. Results In one fifth of the 283 reviews in the sample, more than 50% of the patient data for the primary outcome was missing. Responses to the survey were received from 90% of Co-ordinating Editors. Thirty-six percent of CRGs have a centralized policy regarding which outcomes to include in the SoF table and 73% of Co-ordinating Editors thought that a COS for effectiveness trials should be used routinely for a SoF table. Conclusions The reliability of systematic reviews, in particular meta-analyses they contain, can be improved if more attention is paid to missing outcome data. The availability of COSs for specific health conditions might help with this and the concept has support from the majority of Co-ordinating Editors in CRGs. PMID:23339751

  11. A Study of the Morpho-Semantic Relationship in Medline1

    PubMed Central

    Wilbur, W. John; Smith, Larry

    2014-01-01

    Morphological analysis as applied to English has generally involved the study of rules for inflections and derivations. Recent work has attempted to derive such rules from automatic analysis of corpora. Here we study similar issues, but in the context of the biological literature. We introduce a new approach which allows us to assign probabilities of the semantic relatedness of pairs of tokens that occur in text in consequence of their relatedness as character strings. Our analysis is based on over 84 million sentences from the MEDLINE database, over 2.3 million token types that occur in MEDLINE, and enables us to identify over 36 million token type pairs which have assigned probabilities of semantic relatedness of at least 0.7 based on their similarity as strings. The quality of these predictions is tested by two different manual evaluations and found to be good. PMID:24976874

  12. Developing Optimal Search Strategies for Detecting Clinically Sound Studies in MEDLINE

    Microsoft Academic Search

    R Brian Haynes; Nancy Wilczynski; K Ann McKibbon; Cynthia J Walker; JC Sinclair

    1994-01-01

    ObjectiveTo develop optimal MEDLINE search strategies for retrieving sound clinical studies of the etiology, prognosis, diagnosis, prevention, or treatment of disorders in adult general medicine.DesignAnalytic survey of operating characteristics of search strategies developed by computerized combinations of terms selected to detect studies meeting basic methodologic criteria for direct clinical use in adult general medicine.MeasuresThe sensitivities, specificities, precision, and accuracy of

  13. Development and Implementation of a Microcomputer-based Multi-user MEDLINE System

    Microsoft Academic Search

    Alan C. Simon

    1991-01-01

    The Health Sciences Libraries Consortium, a group of health sciences libraries based in Philadelphia, PA, has implemented a MEDLINE database retrieval system based on the CD Plus PlusNet2 system. The system provides access to the entire MEDLlNE database file through three centralized servers and four distributed servers, and is accessible over the HSLC wide-area network linking all of its members.

  14. Combining MEDLINE and publisher data to create parallel corpora for the automatic translation of biomedical text

    PubMed Central

    2013-01-01

    Background Most of the institutional and research information in the biomedical domain is available in the form of English text. Even in countries where English is an official language, such as the United States, language can be a barrier for accessing biomedical information for non-native speakers. Recent progress in machine translation suggests that this technique could help make English texts accessible to speakers of other languages. However, the lack of adequate specialized corpora needed to train statistical models currently limits the quality of automatic translations in the biomedical domain. Results We show how a large-sized parallel corpus can automatically be obtained for the biomedical domain, using the MEDLINE database. The corpus generated in this work comprises article titles obtained from MEDLINE and abstract text automatically retrieved from journal websites, which substantially extends the corpora used in previous work. After assessing the quality of the corpus for two language pairs (English/French and English/Spanish) we use the Moses package to train a statistical machine translation model that outperforms previous models for automatic translation of biomedical text. Conclusions We have built translation data sets in the biomedical domain that can easily be extended to other languages available in MEDLINE. These sets can successfully be applied to train statistical machine translation models. While further progress should be made by incorporating out-of-domain corpora and domain-specific lexicons, we believe that this work improves the automatic translation of biomedical texts. PMID:23631733

  15. MedlinePlus and the challenge of low health literacy: findings from the Colonias project*

    PubMed Central

    Olney, Cynthia A.; Warner, Debra G.; Reyna, Greysi; Wood, Fred B.; Siegel, Elliot R.

    2007-01-01

    Objective: To explore the potential of a community-based health information outreach project to overcome problems associated with health literacy in low-income Hispanic communities along the Texas-Mexico border. Methods: Using a train-the-trainer approach, community outreach workers known as promotoras were trained by a health information outreach team to search English and Spanish versions of MedlinePlus. These 15 promotoras submitted written examples on a weekly basis of the topics they helped residents explore on MedlinePlus and the ways in which the residents used the information. These weekly reports, along with verbal interviews with promotoras and others in the communities, allowed development of a database of 161 incidents (“stories”) demonstrating how community residents used MedlinePlus. These stories were thematically analyzed to explore how the program benefited participants. Results: The database of stories included examples of community residents becoming better informed about their illnesses, resolving to visit doctors, making decisions about recommended treatments, reducing their anxiety about health conditions, committing to healthy or preventive behavior, and assisting family members. Conclusion: With the help of paraprofessionals like promotoras, community-based health information outreach projects may improve the ability of community residents to understand their health conditions and to participate actively in their health care. PMID:17252064

  16. MEDLINE plus

    Microsoft Academic Search

    Jennifer Reiswig

    2001-01-01

    The Na tional Li brary of Med i cine's MEDLINEplus has come a long way in the past year, and has evolved into a wor thy com pet i -tor to even the best of the com mer cial health por tal sites. This re view will ex am ine the new est de vel op ments on the site

  17. Best Practice Updates for Pediatric\\/Adolescent Weight Loss Surgery

    Microsoft Academic Search

    Janey S. A. Pratt; Carine M. Lenders; Emily A. Dionne; Alison G. Hoppin; George L. K. Hsu; Thomas H. Inge; David F. Lawlor; Margaret F. Marino; Alan F. Meyers; Jennifer L. Rosenblum; Vivian M. Sanchez

    2009-01-01

    The objective of this study is to update evidence-based best practice guidelines for pediatric\\/adolescent weight loss surgery (WLS). We performed a systematic search of English-language literature on WLS and pediatric, adolescent, gastric bypass, laparoscopic gastric banding, and extreme obesity published between April 2004 and May 2007 in PubMed, MEDLINE, and the Cochrane Library. Keywords were used to narrow the search

  18. Chocolate consumption and cardiometabolic disorders: systematic review and meta-analysis

    Microsoft Academic Search

    Adriana Buitrago-Lopez; Jean Sanderson; Laura Johnson; Samantha Warnakula; Angela Wood; Emanuele Di Angelantonio; Oscar H Franco

    2011-01-01

    Objective To evaluate the association of chocolate consumption with the risk of developing cardiometabolic disorders.Design Systematic review and meta-analysis of randomised controlled trials and observational studies.Data sources Medline, Embase, Cochrane Library, PubMed, CINAHL, IPA, Web of Science, Scopus, Pascal, reference lists of relevant studies to October 2010, and email contact with authors.Study selection Randomised trials and cohort, case-control, and cross

  19. Are female athletes at increased risk for disordered eating and its complications?

    Microsoft Academic Search

    Gabriela Morgado de Oliveira Coelho; Eliane de Abreu Soares; Beatriz Gonçalves Ribeiro

    2010-01-01

    The purpose of the study was to make a systematic review and describe and confront recent studies that compare the presence of disordered eating and its complications in young female athletes and controls subjects – PubMed, Scielo, Medline, ScienceDirect, WILEY InterScience, Lilacs and Cochrane were the databases used for this review. Out of 169 studies 22 were selected and 11,000

  20. Weak evidence of caries reduction using xylitol-based lozenges in two of three selected studies

    Microsoft Academic Search

    Brett G Duane

    2012-01-01

    Data sourcesThe Medline, PubMed, ISI Web of Science, LILACS, and Cochrane Library databases and articles from the references of identified articles.Study selectionControlled clinical trials and randomised controlled clinical trials (RCTs) of at least one year investigating the link between consuming xylitol-based lozenges; and caries increment; when compared with a control, in any population group.Data extraction and synthesisTwo examiners independently evaluated

  1. Sedative hypnotics in older people with insomnia: meta-analysis of risks and benefits

    Microsoft Academic Search

    Jennifer Glass; Krista L Lanctôt; Nathan Herrmann; Beth A Sproule; Usoa E Busto

    2005-01-01

    Objectives To quantify and compare potential benefits (subjective reports of sleep variables) and risks (adverse events and morning-after psychomotor impairment) of short term treatment with sedative hypnotics in older people with insomnia. Data sources Medline, Embase, the Cochrane clinical trials database, PubMed, and PsychLit, 1966 to 2003; bibliographies of published reviews and meta-analyses; manufacturers of newer sedative hypnotics (zaleplon, zolpidem,

  2. Adrenergic-?2 receptor polymorphism and athletic performance

    Microsoft Academic Search

    Vishnu Sarpeshkar; David J Bentley

    2010-01-01

    The focus of this review is to evaluate the influence of ?2-adrenergic receptor (ADRB2) polymorphism on human physiological function and in turn on athletic performance. A narrative review is conducted on available literature using MedLine, Pubmed and the Cochrane Library to document the location and function of ADRB2 receptors, and specifically to address the influence of genetic polymorphisms on cardiovascular,

  3. Compared with what? An analysis of control-group types in Cochrane and Campbell reviews of psychosocial treatment efficacy with substance use disorders.

    PubMed

    Karlsson, Patrik; Bergmark, Anders

    2015-03-01

    Background and Aims A crucial, but under-appreciated, aspect in experimental research on psychosocial treatments of substance use disorders concerns what kinds of control groups are used. This paper examines how the distinction between different control-group designs have been handled by the Cochrane and the Campbell Collaborations in their systematic reviews of psychosocial treatments of substance abuse disorders. Methods We assessed Cochrane and Campbell reviews (n?=?8) that were devoted to psychosocial treatments of substance use disorders. We noted what control groups were considered and analysed the extent to which the reviews provided a rationale for chosen comparison conditions. We also analysed whether type of control group in the primary studies influenced how the reviews framed the effects discussed and whether this was related to conclusions drawn. Results The reviews covered studies involving widely different control conditions. Overall, little attention was paid to the use of different control groups (e.g. head-to-head comparisons versus untreated controls) and what this implies when interpreting effect sizes. Seven of eight reviews did not provide a rationale for the choice of comparison conditions. Conclusions Cochrane and Campbell reviews of the efficacy of psychosocial interventions with substance use disorders seem to underappreciate that the use of different control-group types yields different effect estimates. Most reviews have not distinguished between different control-group designs and therefore have provided a confused picture regarding absolute and relative treatment efficacy. A systematic approach to treating different control-group designs in research reviews is necessary for meaningful estimates of treatment efficacy. PMID:25393504

  4. Compared with what? An analysis of control-group types in Cochrane and Campbell reviews of psychosocial treatment efficacy with substance use disorders

    PubMed Central

    Karlsson, Patrik; Bergmark, Anders

    2015-01-01

    Abstract Background and Aims A crucial, but under-appreciated, aspect in experimental research on psychosocial treatments of substance use disorders concerns what kinds of control groups are used. This paper examines how the distinction between different control-group designs have been handled by the Cochrane and the Campbell Collaborations in their systematic reviews of psychosocial treatments of substance abuse disorders. Methods We assessed Cochrane and Campbell reviews (n?=?8) that were devoted to psychosocial treatments of substance use disorders. We noted what control groups were considered and analysed the extent to which the reviews provided a rationale for chosen comparison conditions. We also analysed whether type of control group in the primary studies influenced how the reviews framed the effects discussed and whether this was related to conclusions drawn. Results The reviews covered studies involving widely different control conditions. Overall, little attention was paid to the use of different control groups (e.g. head-to-head comparisons versus untreated controls) and what this implies when interpreting effect sizes. Seven of eight reviews did not provide a rationale for the choice of comparison conditions. Conclusions Cochrane and Campbell reviews of the efficacy of psychosocial interventions with substance use disorders seem to underappreciate that the use of different control-group types yields different effect estimates. Most reviews have not distinguished between different control-group designs and therefore have provided a confused picture regarding absolute and relative treatment efficacy. A systematic approach to treating different control-group designs in research reviews is necessary for meaningful estimates of treatment efficacy. PMID:25393504

  5. Evaluation of the Cochrane Collaboration’s tool for assessing the risk of bias in randomized trials: focus groups, online survey, proposed recommendations and their implementation

    PubMed Central

    2014-01-01

    Background In 2008, the Cochrane Collaboration introduced a tool for assessing the risk of bias in clinical trials included in Cochrane reviews. The risk of bias (RoB) tool is based on narrative descriptions of evidence-based methodological features known to increase the risk of bias in trials. Methods To assess the usability of this tool, we conducted an evaluation by means of focus groups, online surveys and a face-to-face meeting. We obtained feedback from a range of stakeholders within The Cochrane Collaboration regarding their experiences with, and perceptions of, the RoB tool and associated guidance materials. We then assessed this feedback in a face-to-face meeting of experts and stakeholders and made recommendations for improvements and further developments of the RoB tool. Results The survey attracted 380 responses. Respondents reported taking an average of between 10 and 60 minutes per study to complete their RoB assessments, which 83% deemed acceptable. Most respondents (87% of authors and 95% of editorial staff) thought RoB assessments were an improvement over past approaches to trial quality assessment. Most authors liked the standardized approach (81%) and the ability to provide quotes to support judgements (74%). A third of participants disliked the increased workload and found the wording describing RoB judgements confusing. The RoB domains reported to be the most difficult to assess were incomplete outcome data and selective reporting of outcomes. Authors expressed the need for more guidance on how to incorporate RoB assessments into meta-analyses and review conclusions. Based on this evaluation, recommendations were made for improvements to the RoB tool and the associated guidance. The implementation of these recommendations is currently underway. Conclusions Overall, respondents identified positive experiences and perceptions of the RoB tool. Revisions of the tool and associated guidance made in response to this evaluation, and improved provision of training, may improve implementation. PMID:24731537

  6. Generating MEDLINE search strategies using a librarian knowledge-based system.

    PubMed

    Peng, P; Aguirre, A; Johnson, S B; Cimino, J J

    1993-01-01

    We describe a librarian knowledge-based system that generates a search strategy from a query representation based on a user's information need. Together with the natural language parser AQUA, the system functions as a human/computer interface, which translates a user query from free text into a BRS Onsite search formulation, for searching the MEDLINE bibliographic database. In the system, conceptual graphs are used to represent the user's information need. The UMLS Metathesaurus and Semantic Net are used as the key knowledge sources in building the knowledge base. PMID:8130544

  7. Survey of individual users of MEDLINE on the NLM system (Summary)

    NASA Astrophysics Data System (ADS)

    Fukushima, Translated By Isao; Kawano, Koreni

    In the past three years the number of individual health professionals who search with MEDLINE on the NLM system has increased dramatically. It is continuing to grow at the rate of over 200 users per month. In order to provide them with an online information retrieval service that individuals can use easily and effectively, NLM surveyed this growing end-user population by the questionnaire including 35 items such as their demographic characteristics, methods of access to the system, frequency of searching, search purpose, number of citations retrieved, use of information retrieved, and level of satisfaction with current system. This paper describes the results of this survey.

  8. Exploiting MeSH indexing in MEDLINE to generate a data set for word sense disambiguation

    PubMed Central

    2011-01-01

    Background Evaluation of Word Sense Disambiguation (WSD) methods in the biomedical domain is difficult because the available resources are either too small or too focused on specific types of entities (e.g. diseases or genes). We present a method that can be used to automatically develop a WSD test collection using the Unified Medical Language System (UMLS) Metathesaurus and the manual MeSH indexing of MEDLINE. We demonstrate the use of this method by developing such a data set, called MSH WSD. Methods In our method, the Metathesaurus is first screened to identify ambiguous terms whose possible senses consist of two or more MeSH headings. We then use each ambiguous term and its corresponding MeSH heading to extract MEDLINE citations where the term and only one of the MeSH headings co-occur. The term found in the MEDLINE citation is automatically assigned the UMLS CUI linked to the MeSH heading. Each instance has been assigned a UMLS Concept Unique Identifier (CUI). We compare the characteristics of the MSH WSD data set to the previously existing NLM WSD data set. Results The resulting MSH WSD data set consists of 106 ambiguous abbreviations, 88 ambiguous terms and 9 which are a combination of both, for a total of 203 ambiguous entities. For each ambiguous term/abbreviation, the data set contains a maximum of 100 instances per sense obtained from MEDLINE. We evaluated the reliability of the MSH WSD data set using existing knowledge-based methods and compared their performance to that of the results previously obtained by these algorithms on the pre-existing data set, NLM WSD. We show that the knowledge-based methods achieve different results but keep their relative performance except for the Journal Descriptor Indexing (JDI) method, whose performance is below the other methods. Conclusions The MSH WSD data set allows the evaluation of WSD algorithms in the biomedical domain. Compared to previously existing data sets, MSH WSD contains a larger number of biomedical terms/abbreviations and covers the largest set of UMLS Semantic Types. Furthermore, the MSH WSD data set has been generated automatically reusing already existing annotations and, therefore, can be regenerated from subsequent UMLS versions. PMID:21635749

  9. An investigation of the optimization of search logic for the MEDLINE database.

    PubMed

    Heine, M H; Tague, J M

    1991-05-01

    One of the key variables in the optimization of the retrieval process is the logic imposed on a set of query terms. If the query is small, a combinatorial algorithm can be employed to identify search expressions having an optimal logical form. An experiment is described in which this was done for queries expressed against MEDLINE, for a variety of criterion variables. The method employed is useful not only for assisting in identifying optimal logical forms, as demonstrated, but also as an experimental control device to assist investigations into the effects of varying the set, and number, of search terms. The experiment also suggests several novel properties of effective searching against MEDLINE, for example that searching with four MeSH terms is likely to be more successful than searching with a lesser number of terms, provided search logic is optimal. The latter result is, surprisingly, true for both Precision and Recall, i.e., a tradeoff between the maximally attainable values of these variables fails to hold when the number of search terms varies in this range. PMID:10111575

  10. Automatic Summarization of MEDLINE Citations for Evidence–Based Medical Treatment: A Topic-Oriented Evaluation

    PubMed Central

    Fiszman, Marcelo; Demner-Fushman, Dina; Kilicoglu, Halil; Rindflesch, Thomas C.

    2009-01-01

    As the number of electronic biomedical textual resources increases, it becomes harder for physicians to find useful answers at the point of care. Information retrieval applications provide access to databases; however, little research has been done on using automatic summarization to help navigate the documents returned by these systems. After presenting a semantic abstraction automatic summarization system for MEDLINE citations, we concentrate on evaluating its ability to identify useful drug interventions for fifty-three diseases. The evaluation methodology uses existing sources of evidence-based medicine as surrogates for a physician-annotated reference standard. Mean average precision (MAP) and a clinical usefulness score developed for this study were computed as performance metrics. The automatic summarization system significantly outperformed the baseline in both metrics. The MAP gain was 0.17 (p < 0.01) and the increase in the overall score of clinical usefulness was 0.39 (p < 0.05). PMID:19022398

  11. Mining connections between chemicals, proteins, and diseases extracted from Medline annotations.

    PubMed

    Baker, Nancy C; Hemminger, Bradley M

    2010-08-01

    The biomedical literature is an important source of information about the biological activity and effects of chemicals. We present an application that extracts terms indicating biological activity of chemicals from Medline records, associates them with chemical name and stores the terms in a repository called ChemoText. We describe the construction of ChemoText and then demonstrate its utility in drug research by employing Swanson's ABC discovery paradigm. We reproduce Swanson's discovery of a connection between magnesium and migraine in a novel approach that uses only proteins as the intermediate B terms. We validate our methods by using a cutoff date and evaluate them by calculating precision and recall. In addition to magnesium, we have identified valproic acid and nitric oxide as chemicals which developed links to migraine. We hypothesize, based on protein annotations, that zinc and retinoic acid may play a role in migraine. The ChemoText repository has promise as a data source for drug discovery. PMID:20348023

  12. Journal searching in non-MEDLINE resources on Internet Web sites.

    PubMed

    Lingle, V A

    1997-01-01

    Internet access to the medical journal literature is absorbing the attention of all relevant parties, i.e., publishers, journal vendors, librarians, commercial providers, government agencies, and end users. Journal content on the Web sites spans the range from advertising and ordering information for the print version, to table of contents and abstracts, to downloadable full text and graphics of articles. The searching parameters for systems other than MEDLINE also differ extensively with a wide variety of features and resulting retrieval. This discussion reviews a selection of providers of medical information (particularly the journal literature) on the Internet, making a comparison of what is available on Web sites and how it can be searched. PMID:10173597

  13. Developing Optimal Search Strategies for Detecting Sound Clinical Prediction Studies in MEDLINE

    PubMed Central

    Wong, Sharon S.-L.; Wilczynski, Nancy L.; Haynes, R. Brian; Ramkissoonsingh, Ravi; Team, for the Hedges

    2003-01-01

    Background: The gaining interest in the use of clinical prediction guides as an aid for helping clinicians make effective front-line decisions, together with the increasing emphasis on evidence-based practice, underscores the need for accurate identification of sound clinical prediction studies. Despite the growing use of clinical prediction guides, little work has been done on identifying optimal literature search filters for retrieving these types of studies. The current study extends our earlier work, on developing optimal search strategies, to include clinical prediction guides. Objective: To develop optimal search strategies for detecting methodologically sound clinical prediction studies in MEDLINE in the publishing year 2000. Design : Comparison of the retrieval performance of methodologic search strategies in MEDLINE with a manual review (“gold standard”) of each article for each issue of 161 core health care journals for the year 2000. Methods: 6 experienced research assistants who had been trained and intensively calibrated reviewed all issues of 161 journals for the publishing year 2000. Each article was classified for format, interest, purpose, and methodologic rigor. Search strategies were developed for all purpose categories, including studies of clinical prediction guides. Main outcome measures: The sensitivity (recall), specificity, precision, and accuracy of single and combinations of search terms. Results: 39% of original studies classified as a clinical prediction guide were methodologically sound. Combinations of terms reached peak sensitivities of 95%. Compared with the best single term, a three-term strategy increased sensitivity for sound studies by 17% (absolute increase), but with some loss of specificity when sensitivity was maximized. When search terms were combined to optimize sensitivity and specificity, these values reached or were close to 90%. Conclusion: Several search strategies can enhance the retrieval of sound clinical prediction studies. PMID:14728269

  14. Citation: Smyth, G. K., Yang, Y.-H., Speed, T. P. (2003). Statistical issues in cDNA microarray data analysis. Methods in Molecular Biology 224, 111-136. [PubMed ID 12710670

    E-print Network

    Smyth, Gordon K.

    data analysis. Methods in Molecular Biology 224, 111-136. [PubMed ID 12710670] Statistical Issues in cCitation: Smyth, G. K., Yang, Y.-H., Speed, T. P. (2003). Statistical issues in cDNA microarray Institute of Medical Research 2. Department of Statistics, University of California, Berkeley Address

  15. HIV/AIDS knowledge among female migrant farm worke...[J Immigr Health. 2003] -PubMed Result 1: J Immigr Health. 2003 Jan;5(1):29-36. Links

    E-print Network

    Abraham, Nader G.

    HIV/AIDS knowledge among female migrant farm worke...[J Immigr Health. 2003] - PubMed Result 1: J Immigr Health. 2003 Jan;5(1):29-36. Links HIV/AIDS knowledge among female migrant farm workers of Ohio, Toledo, Ohio 43614-5809, USA. The rate of HIV infection in the migrant farm worker community

  16. PMD2HD – A web tool aligning a PubMed search results page with the local German Cancer Research Centre library collection

    PubMed Central

    Bohne-Lang, Andreas; Lang, Elke; Taube, Anke

    2005-01-01

    Background Web-based searching is the accepted contemporary mode of retrieving relevant literature, and retrieving as many full text articles as possible is a typical prerequisite for research success. In most cases only a proportion of references will be directly accessible as digital reprints through displayed links. A large number of references, however, have to be verified in library catalogues and, depending on their availability, are accessible as print holdings or by interlibrary loan request. Methods The problem of verifying local print holdings from an initial retrieval set of citations can be solved using Z39.50, an ANSI protocol for interactively querying library information systems. Numerous systems include Z39.50 interfaces and therefore can process Z39.50 interactive requests. However, the programmed query interaction command structure is non-intuitive and inaccessible to the average biomedical researcher. For the typical user, it is necessary to implement the protocol within a tool that hides and handles Z39.50 syntax, presenting a comfortable user interface. Results PMD2HD is a web tool implementing Z39.50 to provide an appropriately functional and usable interface to integrate into the typical workflow that follows an initial PubMed literature search, providing users with an immediate asset to assist in the most tedious step in literature retrieval, checking for subscription holdings against a local online catalogue. Conclusion PMD2HD can facilitate literature access considerably with respect to the time and cost of manual comparisons of search results with local catalogue holdings. The example presented in this article is related to the library system and collections of the German Cancer Research Centre. However, the PMD2HD software architecture and use of common Z39.50 protocol commands allow for transfer to a broad range of scientific libraries using Z39.50-compatible library information systems. PMID:15982415

  17. How much do you need: a randomised experiment of whether readers can understand the key messages from summaries of Cochrane Reviews without reading the full review

    PubMed Central

    Clarke, Mike

    2014-01-01

    Objective We explored whether readers can understand key messages without having to read the full review, and if there were differences in understanding between various types of summary. Design A randomised experiment of review summaries which compared understanding of a key outcome. Participants Members of university staff (n?=?36). Setting Universities on the island of Ireland. Method The Cochrane Review chosen examines the health impacts of the use of electric fans during heat waves. Participants were asked their expectation of the effect these would have on mortality. They were then randomly assigned a summary of the review (i.e. abstract, plain language summary, podcast or podcast transcription) and asked to spend a short time reading/listening to the summary. After this they were again asked about the effects of electric fans on mortality and to indicate if they would want to read the full Review. Main outcome measure Correct identification of a key review outcome. Results Just over half (53%) of the participants identified its key message on mortality after engaging with their summary. The figures were 33% for the abstract group, 50% for both the plain language and transcript groups and 78% for the podcast group. Conclusions The differences between the groups were not statistically significant but suggest that the audio summary might improve knowledge transfer compared to written summaries. These findings should be explored further using a larger sample size and with other reviews. PMID:25341445

  18. Mining characteristics of epidemiological studies from Medline: a case study in obesity

    PubMed Central

    2014-01-01

    Background The health sciences literature incorporates a relatively large subset of epidemiological studies that focus on population-level findings, including various determinants, outcomes and correlations. Extracting structured information about those characteristics would be useful for more complete understanding of diseases and for meta-analyses and systematic reviews. Results We present an information extraction approach that enables users to identify key characteristics of epidemiological studies from MEDLINE abstracts. It extracts six types of epidemiological characteristic: design of the study, population that has been studied, exposure, outcome, covariates and effect size. We have developed a generic rule-based approach that has been designed according to semantic patterns observed in text, and tested it in the domain of obesity. Identified exposure, outcome and covariate concepts are clustered into health-related groups of interest. On a manually annotated test corpus of 60 epidemiological abstracts, the system achieved precision, recall and F-score between 79-100%, 80-100% and 82-96% respectively. We report the results of applying the method to a large scale epidemiological corpus related to obesity. Conclusions The experiments suggest that the proposed approach could identify key epidemiological characteristics associated with a complex clinical problem from related abstracts. When integrated over the literature, the extracted data can be used to provide a more complete picture of epidemiological efforts, and thus support understanding via meta-analysis and systematic reviews. PMID:24949194

  19. Mining connections between chemicals, proteins, and diseases extracted from Medline annotations

    PubMed Central

    Baker, Nancy C.; Hemminger, Bradley M.

    2010-01-01

    The biomedical literature is an important source of information about the biological activity and effects of chemicals. We present an application that extracts terms indicating biological activity of chemicals from Medline records, associates them with chemical name and stores the terms in a repository called ChemoText. We describe the construction of ChemoText and then demonstrate its utility in drug research by employing Swanson’s ABC discovery paradigm. We reproduce Swanson’s discovery of a connection between magnesium and migraine in a novel approach that uses only proteins as the intermediate B terms. We validate our methods by using a cutoff date and evaluate them by calculating precision and recall. In addition to magnesium, we have identified valproic acid and nitric oxide as chemicals which developed links to migraine. We hypothesize, based on protein annotations, that zinc and retinoic acid may play a role in migraine. The ChemoText repository has promise as a data source for drug discovery. PMID:20348023

  20. Multivariate versions of Cochran's theorems

    Microsoft Academic Search

    Chi Song Wong; Joe Masaro; Tonghui Wang

    1991-01-01

    Let E, V be n-, p-dimensional inner product spaces over the real field, let (V, E) be the set of all linear maps of V into E, and let Y be a normal random vector in (V, E) with mean [mu] = 0 and covariance [Sigma]Y such that S1 [square not subset] S2([not equal to] }0{) is the image set,

  1. Analysis of Assembly Bill 513, Health Care Coverage: Breastfeeding

    E-print Network

    2009-01-01

    Medline), the Cochrane Library, the CABI Bioscience Database, EconLit, Global Health, Google Scholar, Scientific Web Plus,Medline), the Cochrane Library, the CABI Bioscience Database, EconLit, Global Health, Google Scholar, Scientific Web Plus,

  2. Prophylactic cranial irradiation for preventing brain metastases in patients undergoing radical treatment for non-small-cell lung cancer: A Cochrane Review

    SciTech Connect

    Lester, Jason Francis [Department of Oncology, Velindre Hospital, Whitchurch, Cardiff, Wales (United Kingdom)]. E-mail: jason.lester@velindre-tr.wales.nhs.uk; MacBeth, Fergus R. [Department of Oncology, Velindre Hospital, Whitchurch, Cardiff, Wales (United Kingdom); Coles, Bernadette [Department of Oncology, Velindre Hospital, Whitchurch, Cardiff, Wales (United Kingdom)

    2005-11-01

    Purpose: To investigate whether prophylactic cranial irradiation (PCI) has a role in the management of patients with non-small-cell lung cancer (NSCLC) treated with curative intent. Methods and Materials: A search strategy was designed to identify randomized controlled trials (RCTs) comparing PCI with no PCI in NSCLC patients treated with curative intent. The electronic databases MEDLINE, EMBASE, LILACS, and Cancerlit were searched, along with relevant journals, books, and review articles to identify potentially eligible trials. Four RCTs were identified and reviewed. A total of 951 patients were randomized in these RCTs, of whom 833 were evaluable and reported. Forty-two patients with small-cell lung cancer were excluded, leaving 791 patients in total. Because of the small patient numbers and trial heterogeneity, no meta-analysis was attempted. Results: Prophylactic cranial irradiation did significantly reduce the incidence of brain metastases in three trials. No trial reported a survival advantage with PCI over observation. Toxicity data were poorly collected and no quality of life assessments were carried out in any trial. Conclusion: Prophylactic cranial irradiation may reduce the incidence of brain metastases, but there is no evidence of a survival benefit. It was not possible to evaluate whether any radiotherapy regimen is superior, and the effect of PCI on quality of life is not known. There is insufficient evidence to support the use of PCI in clinical practice. Where possible, patients should be offered entry into a clinical trial.

  3. Full-text and bibliographic database searching in the health sciences: an exploratory study comparing CCML and MEDLINE.

    PubMed

    Gallagher, K E; Hulbert, L A; Sullivan, C P

    1990-01-01

    An exploratory study to investigate perceived differences between searching full-text databases and bibliographic databases was undertaken. BRS's full-text database, Comprehensive Core Medical Library (CCML), and BRS's current MEDLINE file (MESH) were compared. Identical literature search topics were run in the two databases and the results evaluated regarding currency of search results, success in answering specific questions, uniqueness of information retrieved, and relevancy of retrieval. Additionally, connect time and costs were noted to aid in determining the feasibility of offering full-text database searching as a service for which the authors' institution would charge. PMID:10110455

  4. Public Library Participation in a MedlinePlus® Go Local Project: Perceptions of Georgia Librarians and Staff

    PubMed Central

    Smith, Rita B.

    2010-01-01

    In an effort to promote public library involvement in Georgia Health – Go Local, a National Library of Medicine initiative to link consumers to health resources in their local areas, staff at a large public library system in south Georgia were trained to enter local records into the Go Local database. Results of two follow-up focus groups indicated that participants were enthusiastic about demonstrating Go Local and MedlinePlus to library users but were not comfortable creating or maintaining Go Local records due to concerns about the relevance of the project, unease with medical terminology, varied levels of computer expertise, and worries about possible liability. PMID:21197119

  5. Public Library Participation in a MedlinePlus Go Local Project: Perceptions of Georgia Librarians and Staff.

    PubMed

    Smith, Rita B

    2010-01-01

    In an effort to promote public library involvement in Georgia Health - Go Local, a National Library of Medicine initiative to link consumers to health resources in their local areas, staff at a large public library system in south Georgia were trained to enter local records into the Go Local database. Results of two follow-up focus groups indicated that participants were enthusiastic about demonstrating Go Local and MedlinePlus to library users but were not comfortable creating or maintaining Go Local records due to concerns about the relevance of the project, unease with medical terminology, varied levels of computer expertise, and worries about possible liability. PMID:21197119

  6. Efficacy of black cohosh (Cimicifuga racemosa) medicines for treatment of menopausal symptoms - comments on major statements of the Cochrane Collaboration report 2012 "black cohosh (Cimicifuga spp.) for menopausal symptoms (review)".

    PubMed

    Beer, André-M; Osmers, Rüdiger; Schnitker, Jörg; Bai, Wenpei; Mueck, Alfred O; Meden, Harald

    2013-12-01

    Menopausal symptoms management with high-quality plant extracts from Actaea (Cimicifuga. racemosa rootstock is well-established. Efficacy and safety are supported by research and clinical trials since several decades and backed up by official monographs. However, the recent published Cochrane review on black cohosh neglects major evidence for beneficial effects. The authors' negative conclusions are questionable and call for reply and clarification. Our careful reconsideration of all appropriate placebo-controlled clinical studies reveals a standardized mean difference of 0.385 in favor of black cohosh (p?

  7. The role of the health services in the prevention of alcohol-related facial injury.

    PubMed

    McHugh, E E; Al-Awadhi, E; Stassen, L F A

    2009-10-01

    This paper outlines the preventive health strategic measures that are currently in place and it endeavours to consider how improvements can be made to our national preventive strategy with the goal of reducing alcohol-related facial injuries. It is based on a review of the literature sourced through PubMed, Ovid Medline and the Cochrane database. The main findings are that increased funding, legislative amendment and media involvement are key to improving the work of the health services in their struggle to limit the ever increasing alcohol-related incidents that are experienced by society today. PMID:19848065

  8. Efficacy and safety of atomoxetine for attention-deficit\\/hyperactivity disorder in children and adolescents—meta-analysis and meta-regression analysis

    Microsoft Academic Search

    Jackie Y. W. Cheng; Ronald Y. L. Chen; John S. N. Ko; Emil M. L. Ng

    2007-01-01

    Objectives  The objective of this study was to evaluate the efficacy and safety of atomoxetine in children and adolescents.\\u000a \\u000a \\u000a \\u000a Materials and methods  We searched for studies published between 1985 and 2006 through Medline, PubMed, PsychInfo and Cochrane Central Register of\\u000a Controlled Trials (CENTRAL 2006 Issue 3) using keywords related to atomoxetine and attention-deficit\\/hyperactivity disorder\\u000a (ADHD) and scanned though reference lists. We included

  9. Treatment of Obesity in Primary Care Practice in the United States: A Systematic Review

    Microsoft Academic Search

    Adam Gilden Tsai; Thomas A. Wadden

    2009-01-01

    OBJECTIVES  This review examines the results of randomized controlled trials in which behavioral weight loss interventions, used alone\\u000a or with pharmacotherapy, were provided in primary care settings.\\u000a \\u000a \\u000a \\u000a DATA SOURCES  Literature search of MEDLINE, PubMed, Cochrane Systematic Reviews, CINAHL, and EMBASE (1950-present). Inclusion criteria for\\u000a studies were: (1) randomized trial, (2) obesity intervention in US adults, and (3) conducted in primary care or

  10. Network-based analysis reveals distinct association patterns in a semantic MEDLINE-based drug-disease-gene network

    PubMed Central

    2014-01-01

    Background A huge amount of associations among different biological entities (e.g., disease, drug, and gene) are scattered in millions of biomedical articles. Systematic analysis of such heterogeneous data can infer novel associations among different biological entities in the context of personalized medicine and translational research. Recently, network-based computational approaches have gained popularity in investigating such heterogeneous data, proposing novel therapeutic targets and deciphering disease mechanisms. However, little effort has been devoted to investigating associations among drugs, diseases, and genes in an integrative manner. Results We propose a novel network-based computational framework to identify statistically over-expressed subnetwork patterns, called network motifs, in an integrated disease-drug-gene network extracted from Semantic MEDLINE. The framework consists of two steps. The first step is to construct an association network by extracting pair-wise associations between diseases, drugs and genes in Semantic MEDLINE using a domain pattern driven strategy. A Resource Description Framework (RDF)-linked data approach is used to re-organize the data to increase the flexibility of data integration, the interoperability within domain ontologies, and the efficiency of data storage. Unique associations among drugs, diseases, and genes are extracted for downstream network-based analysis. The second step is to apply a network-based approach to mine the local network structure of this heterogeneous network. Significant network motifs are then identified as the backbone of the network. A simplified network based on those significant motifs is then constructed to facilitate discovery. We implemented our computational framework and identified five network motifs, each of which corresponds to specific biological meanings. Three case studies demonstrate that novel associations are derived from the network topology analysis of reconstructed networks of significant network motifs, further validated by expert knowledge and functional enrichment analyses. Conclusions We have developed a novel network-based computational approach to investigate the heterogeneous drug-gene-disease network extracted from Semantic MEDLINE. We demonstrate the power of this approach by prioritizing candidate disease genes, inferring potential disease relationships, and proposing novel drug targets, within the context of the entire knowledge. The results indicate that such approach will facilitate the formulization of novel research hypotheses, which is critical for translational medicine research and personalized medicine. PMID:25170419

  11. Information Resources Diseases Affecting Homeostasis and Cardiology

    E-print Network

    Kim, Duck O.

    Medicine's professional content undergoes 4 levels of physician peer review plus an additional review by a PharmD prior, and chemical agents. Pubmed (Medline) PubMed provides access to bibliographic information, which is drawn primarily from Medline. Medline indexes over 4,600 medical journals from 1966. PubMed also provides access

  12. Integrating CD-ROM Medline with electronic mail: first step in implementing new strategy for online reference library.

    PubMed

    Ribitzky, R

    1991-01-01

    Simultaneous ACCESS to and DISSEMINATION of electronically available PROFESSIONAL KNOWLEDGE, in a productive, Cost-of-Ownership effective, and affordable manner are now achievable. Emerging MANAGEMENT-OF-INFORMATION and SYSTEMS-INTEGRATION disciplines are essential contributing factors to devising and implementing NEW STRATEGIES for ONLINE REFERENCE LIBRARIES. Bringing integrated information closer to the ultimate user and RESHAPING the electronic databases and full-text management systems MARKETPLACE are the most significant outcomes. Key technology attributes are advancements in CD-ROM, Networking, and office automation. We have proven this concept by developing an INTERFACE between MEDLINE from COMPACT CAMBRIDGE and ALL-IN-1 from DIGITAL EQUIPMENT CORPORATION. Saved search results are automatically routed to the individual's ALL-IN-1 account where further DOCUMENT MANAGEMENT and electronic mail functions may be performed. A 486Ware system from Logicraft and a five-members VAX-Cluster (respectively), are linked in a DECNet environment that is the foundation of Children's Integrated Hospital Information System. In phase one of the project up to 8 SIMULTANEOUS USERS may access the 8 RECENT YEARS, from any one of 1500 ACCESS POINTS (local and remote), and utilize any one of 150 NETWORKED PRINTERS. Opportunities are now within reach to expand the electronic library services while utilizing progressive methods and taking advantage of the best available technologies. PMID:1807668

  13. How to do a quick search for evidence.

    PubMed

    Isaacs, David

    2014-08-01

    Doctors quote lack of time and lack of knowledge as major obstacles to searching the literature for evidence. This article argues that it is possible to do a literature search in 10-15 minutes with little specialist knowledge, using the Clinical Queries option of Medline (PubMed). PubMed is a free, user friendly service available to anyone with access to the internet and designed by librarians for use by clinicians who are not skilled in electronic searching. Numerous hidden search filters built into Clinical Queries facilitate targeted searches and find all published systematic reviews (including Cochrane Reviews). If no systematic reviews are available, the clinician can find randomised controlled trials and observational studies. PMID:24612231

  14. About MedlinePlus

    MedlinePLUS

    ... Director Dr. Donald A.B. Lindberg, Director, National Library of Medicine View Dr. Lindberg's welcome (Quicktime video ... good health information from the world's largest medical library, the National Library of Medicine. Health professionals and ...

  15. CD Plus' OVID MEDLINE

    Microsoft Academic Search

    Frances A. Brahmi; Kellie Kaneshiro

    1994-01-01

    CD Plus' OVID software is discussed in relation to CD Plus' previous software, CDP 2.0. Two versions of OVID are reviewed-3.0 (Release 8) and 2.1 (Release 3), tested as a beta product at the Ruth Lilly Medical Library (RLML) in Indianapolis. OVID 2.1, a hybrid between CDP and OVID 3.0, was designed to facilitate the transition between CDP and OVID.

  16. Effects of changes in the economic environment on diet- and physical activity related behaviours and corollary outcomes: a large-scale scoping review.

    E-print Network

    Shemilt, Ian; Hollands, Gareth J; Marteau, Theresa M; Jebb, Susan A; Kelly, Michael P; Nakamura, Ryota; Suhrcke, Marc; Ogilvie, David

    : MEDLINE (Ovid); EMBASE (Ovid); PsycINFO (Ovid); EconLit (EBSCO); SPORTDiscus with Full Text (EBSCO); Applied Social April 2013 14 Sciences Index and Abstracts (CSA Illumina); Cochrane Database of Systematic Reviews (The Cochrane Library, Wiley...

  17. CONFERENCE SPONSORS AND EXHIBITORS Mark Cochran

    E-print Network

    Soerens, Thomas

    _usrey@nps.gov Tara Verkler UA Division of Agriculture tverkle@uark.edu Brian Wagner AR Game and Fish Commission the United States. The State Water Resources Research Center Institutes were charged with arranging Oklahoma Scenic River Commission grstub@hotmail.com Rusty Tate Beaver Water District rtate@bwdh2o.org Barry

  18. Risk factors for bone metastasis in patients with primary lung cancer: study protocol for a systematic review

    PubMed Central

    Niu, Yu-Jie; Wen, Yin-Tian; Shen, Wei-Wei; Deng, Lin; Liu, Li-Li; Zhang, He-Long

    2014-01-01

    Introduction Bone metastasis (BM) in patients with primary lung cancer poses a serious health problem. Numerous risk factors have been hypothesised to predict BM in these patients, but research studies are of mutable quality, and may not be of value in clinical evaluation. Methods and analysis We will search a number of electronic databases including PubMed, MEDLINE, Web of Science, EMBASE, the Cochrane Library (Cochrane Database of Systematic Reviews) and the Cochrane Central Register of Controlled Trials (CENTRAL). We will carry out a secondary search for articles from references of included articles (from January 1990 to June 2014). Primary and secondary outcomes will be BM and skeletal-related events information. We will summarise the effect estimates of risk factors and use random-effect models to pool the estimates, if the outcomes and characteristics in studies are comparable. The quality of the study will be assessed using the Newcastle–Ottawa Scale and the Cochrane Collaboration tool. Trial registration number CRD42013003744. PMID:25059970

  19. Comparing the Precision of Information Retrieval of MeSH-Controlled Vocabulary Search Method and a Visual Method in the Medline Medical Database

    PubMed Central

    Hariri, Nadjla; Ravandi, Somayyeh Nadi

    2014-01-01

    Background: Medline is one of the most important databases in the biomedical field. One of the most important hosts for Medline is Elton B. Stephens CO. (EBSCO), which has presented different search methods that can be used based on the needs of the users. Visual search and MeSH-controlled search methods are among the most common methods. The goal of this research was to compare the precision of the retrieved sources in the EBSCO Medline base using MeSH-controlled and visual search methods. Methods: This research was a semi-empirical study. By holding training workshops, 70 students of higher education in different educational departments of Kashan University of Medical Sciences were taught MeSH-Controlled and visual search methods in 2012. Then, the precision of 300 searches made by these students was calculated based on Best Precision, Useful Precision, and Objective Precision formulas and analyzed in SPSS software using the independent sample T Test, and three precisions obtained with the three precision formulas were studied for the two search methods. Results: The mean precision of the visual method was greater than that of the MeSH-Controlled search for all three types of precision, i.e. Best Precision, Useful Precision, and Objective Precision, and their mean precisions were significantly different (P <0.001). Sixty-five percent of the researchers indicated that, although the visual method was better than the controlled method, the control of keywords in the controlled method resulted in finding more proper keywords for the searches. Fifty-three percent of the participants in the research also mentioned that the use of the combination of the two methods produced better results. Conclusion: For users, it is more appropriate to use a natural, language-based method, such as the visual method, in the EBSCO Medline host than to use the controlled method, which requires users to use special keywords. The potential reason for their preference was that the visual method allowed them more freedom of action.

  20. Bestandsvergelijking BMT Naam bestand en algemene opmerkingen Omschrijving vakgebieden Inhoud

    E-print Network

    Franssen, Michael

    of Medicine (NLM) en wordt aangeboden op Internet. Het is vrij toegankelijk. Pubmed bevat alle Medline aanduiding [PubMed - indexed for MEDLINE]. Er zijn diverse basiszoekfuncties beschikbaar. De "automatic is de meest gebruikte database op medisch gebied. Medline via OvidSP Biomedisch Gericht zoeken kan met

  1. Citation Analysis using the Medline Database at the Web of Knowledge: Searching "Times Cited" with Medical Subject Headings (MeSH)

    E-print Network

    Leydesdorff, Loet

    2012-01-01

    Citation analysis of documents retrieved from the Medline database (at the Web of Knowledge) has been possible only on a case-by-case basis. A technique is here developed for citation analysis in batch mode using both Medical Subject Headings (MeSH) at the Web of Knowledge and the Science Citation Index at the Web of Science. This freeware routine is applied to the case of "Brugada Syndrome," a specific disease and field of research (since 1992). The journals containing these publications are attributed to Web-of-Science Categories other than "Cardiac and Cardiovascular Systems"), perhaps because of the possibility of genetic testing for this syndrome in the clinic. With this routine, all the instruments available for citation analysis can be used on the basis of MeSH terms.

  2. JICST-E (Japan Information Centre of Science and Technology—English File): its construction in providing access to online Japanese biomedical information with selected comparisons to EMBASE and MEDLINE

    Microsoft Academic Search

    R. J. Sodha; B. J. Kostrewski; O. Schier

    1990-01-01

    The database JICST-E (Japan Information Centre of Sci ence and and Technology, English language database in Sci ence, Technology and Medicine) is compared with EMBASE and MEDLINE for the coverage of Japanese biomedical litera ture. Six different searches were run in each of these databases using the terms (1) diclofenac, (2) lymphokine activated killer cells, (3) tumour necrosis factor, (4)

  3. National Library of Medicine Guide to Finding Health Information

    MedlinePLUS

    ... Health Questions including pill identification, lab test results, directories, codes, statistics, and more. MedlinePlus ® information on hundreds of diseases, conditions, drugs, health topics, and directories. PubMed ® to search MEDLINE ® for citations to professional ...

  4. Incidence of neoplasms in the most prevalent autoimmune rheumatic diseases: a systematic review.

    PubMed

    Machado, Roberta Ismael Lacerda; Braz, Alessandra de Sousa; Freire, Eutilia Andrade Medeiros

    2014-01-01

    This article is a systematic review of the literature about the coexistence of cancer and autoimmune rheumatic diseases, their main associations, cancers and possible risk factors associated, with emphasis on existing population-based studies, besides checking the relation of this occur with the use of the drugs used in the treatment of autoimmune diseases. A search was conducted of scientific articles indexed in the Cochrane / BVS, Pubmed / Medline and Scielo / Lilacs in the period from 2002 to 2012. Also consulted was the IB-ICT (Brazilian digital library of theses and Masters), with descriptors in Portuguese and English for "Systemic sclerosis", "Rheumatoid Arthritis", " Systemic Lupus Erythematosus" and "Sjögren's syndrome", correlating each one with the descriptor AND "neoplasms". The results showed that in the database IBICT a thesis and a dissertation for the descriptor SLE met the inclusion criteria, none met RA one thesis to SS. Lilacs in the database/Scielo found two articles on "Rheumatoid Arthritis" AND "neoplasms". In Pubmed/Medline the inicial search resulted in 118 articles, and 41 were selected. The review noted the relationship between cancer and autoimmune rheumatic diseases, as well as a risk factor for protection, although the pathophysiological mechanisms are not known. PMID:24878860

  5. Clinical significance of early treatment of overjet is questionable

    Microsoft Academic Search

    Carlos Flores-Mir

    2007-01-01

    Data sourcesLiterature searches were made within the Cochrane Oral Health Group's Trials Register, Cochrane Central Register of Controlled Trials, Medline and Embase, and articles were also identified as part of the Cochrane Oral Health Group's handsearching programme from the following sources: American Journal of Orthodontics and Dentofacial Orthopedics, The Angle Orthodontist, European Journal of Orthodontics and Journal of Orthodontics. In

  6. Topical fluorides provide additional benefit when used with fluoride toothpaste

    Microsoft Academic Search

    Michael Monopoli

    2004-01-01

    Data sources Cochrane Oral Health Group's Trials Register (May 2000), the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library Issue 2, 2000), MEDLINE (1966 to January 2000), plus several other databases. We handsearched journals, reference lists of articles and contacted selected authors and manufacturers.Study selection Randomized or quasi-randomized controlled trials with blind outcome assessment, comparing fluoride varnish, gel,

  7. Nanotechnology and its Application in Dentistry

    PubMed Central

    Abiodun-Solanke, IMF; Ajayi, DM; Arigbede, AO

    2014-01-01

    Nanotechnology influences almost every facet of everyday life from security to medicine. The concept of nanotechnology is that when one goes down to the bottom of things, one can discover unlimited possibilities and potential of the basic particle. In nanotechnology, analysis can be made to the level of manipulating atoms, molecules and chemical bonds between them. The growing interest in the dental applications of nanotechnology is leading to the emergence of a new field called nanodentistry. An electronic database search that included PubMed, MedLine, and Cochrane library was conducted. Key words used in the search are nanotechnology dentistry and applications. Language limitation was set as articles reviewed were only those written and published in English language. We did not search the gray literature. Initially, 52 articles were retrieved from the database, and articles considered were those published from 2008 to 2013. Eight articles that met the selection criteria were eventually selected and reviewed. PMID:25364585

  8. Association between central auditory processing mechanism and cardiac autonomic regulation

    PubMed Central

    2014-01-01

    Background This study was conducted to describe the association between central auditory processing mechanism and the cardiac autonomic regulation. Methods It was researched papers on the topic addressed in this study considering the following data bases: Medline, Pubmed, Lilacs, Scopus and Cochrane. The key words were: “auditory stimulation, heart rate, autonomic nervous system and P300”. Results The findings in the literature demonstrated that auditory stimulation influences the autonomic nervous system and has been used in conjunction with other methods. It is considered a promising step in the investigation of therapeutic procedures for rehabilitation and quality of life of several pathologies. Conclusion The association between auditory stimulation and the level of the cardiac autonomic nervous system has received significant contributions in relation to musical stimuli. PMID:24834128

  9. Association of the metformin with the risk of lung cancer: a meta-analysis

    PubMed Central

    Wang, Li; Wu, Guan-Nan; Yuan, Dong-Mei

    2013-01-01

    Objective To assess the correlation between metformin and risk of developing lung cancer by meta-analysis. Methods Papers on the correlation between metformin and risk of lung cancer were searched from PubMed, MEDLINE, EMBASE, ISI Web of Science, and Cochrane Library. Results Six papers on case-control study were included in this study, involving 39,787 metformin users and 177,752 controls. Meta-analysis showed that the risk of developing lung cancer was lower in metformin users than in those without metformin (OR=0.55, 95% CI: 0.35-0.85, P<0.001). Conclusions The risk of developing lung cancer is lower in metformin users than in those without metformin.

  10. The interactions between hemostasis and resistance training: a review

    PubMed Central

    Nascimento, Dahan da Cunha; Neto, Frederico Ribeiro; de Santana, Frederico Santos; da Silva, Renato André Sousa; dos Santos-Neto, Leopoldo; Balsamo, Sandor

    2012-01-01

    Physical inactivity is considered a risk factor for cardiovascular disease and is strongly associated with changes in arterial structure. Regular physical activity and exercise contributes to the prevention of coronary artery disease. Therefore, cardiovascular and resistance training improve hemostatic parameters and promote a less thrombotic blood profile. This review highlights the studies, mechanisms, and outcomes relating to the effectiveness of resistance training on the process of hemostasis. The Pubmed, Scopus, Medline, Scielo, Lilacs, Ibecs, and Cochrane databases were used to locate the original articles. Seventeen studies were found during the research process. Of these, ten articles were excluded. Those protocols using a high volume of training for young adults showed a greater fibrinolytic response, and training protocols with intensities above 80% of 1 maximum repetition showed an increased platelet activity. In subjects with coronary artery disease, just one session of resistance training resulted in improvement in the fibrinolytic system (tissue plasminogen activator) without raising potential thrombotic markers. PMID:22419885

  11. Application of low frequency and medium frequency currents in the management of acute and chronic pain-a narrative review.

    PubMed

    Samuel, Stephen Rajan; Maiya, G Arun

    2015-01-01

    Trancutaneous electrical nerve stimulation (TENS) and interferential therapy (IFT) have been a regular line of treatment for various types of acute and chronic pain. This review aims to compile the latest literature in pain management using these modalities which use low-frequency and medium-frequency currents. The Cochrane Library, Scopus, PubMed, MEDLINE, and CINAHL were searched and studies were examined from their inception till October 2013. After title and abstract screening the relevant studies were included for this review. We found through this review that even though TENS and IFT are used in management of pain, there is limited amount of high quality research available in this area. Most of the studies lack methodological quality and have a low sample size. PMID:25709199

  12. Pharmacological treatments for frontotemporal dementias: a systematic review of randomized controlled trials.

    PubMed

    Nardell, Maria; Tampi, Rajesh R

    2014-03-01

    The objective of this review is to summarize the current data on the pharmacological treatments for frontotemporal dementias from randomized controlled trials. A systematic search of 4 major databases, PubMed, Medline, PsychINFO and Cochrane, found a total of 9 randomized controlled, double-blinded clinical trials. Of these, 2 trials used the selective serotonin reuptake inhibitor (SSRI), paroxetine; 1 trial used trazodone; 2 trials used stimulants (methylphenidate and dextroamphetamine); 1 trial used the acetylcholinesterase inhibitor, galantamine; 2 trials used the N-methyl-d-aspartate antagonist, memantine; and 1 trial used the neuropeptide oxytocin. The analysis of the available data indicates that SSRIs, trazodone, and the amphetamines may be effective in reducing some behavioral symptoms, but none of these medications had an impact on cognition. Available data indicate that these medications were well tolerated in all the trials. PMID:24164931

  13. Picture perfect: benefits and risk of fetal 3D ultrasound.

    PubMed

    Wiseman, Claudia S; Kiehl, Ermalynn M

    2007-01-01

    The purpose of this literature review was to survey available information and research related to routine three-dimensional (3D) ultrasound technology in obstetrics, with an emphasis on current medical uses, safety, and availability issues. Several data bases, including Cochrane, WHO, NIH, CINALH, Blackwell Synergy, ERIC, PubMed, and Medline, were used along with information from Internet search engines. Although fetal 3D ultrasound is used in both medical and commercial settings, recent studies focus on its possible uses rather than the more difficult issues of safety and commercial applications. Professional organizations associated with ultrasound technology support limiting ultrasounds in pregnancy to medically necessary events, whereas commercial venues use "direct to consumer" marketing to promote this technology as a way to "see" the baby before it is born. How safe is routine or frequent use of 3D ultrasound? Further research is needed to address these important questions. PMID:17356416

  14. An Evidence-Based Review of Fat Modifying Supplemental Weight Loss Products

    PubMed Central

    Egras, Amy M.; Hamilton, William R.; Lenz, Thomas L.; Monaghan, Michael S.

    2011-01-01

    Objective. To review the literature on fat modifying dietary supplements commonly used for weight loss. Methods. Recently published randomized, placebo-controlled trials were identified in PubMed, MEDLINE, International Pharmaceutical Abstracts, Cochrane Database, and Google Scholar using the search terms dietary supplement, herbal, weight loss, obesity, and individual supplement names. Discussion. Data for conjugated linoleic acid (CLA), Garcinia cambogia, chitosan, pyruvate, Irvingia gabonensis, and chia seed for weight loss were identified. CLA, chitosan, pyruvate, and Irvingia gabonensis appeared to be effective in weight loss via fat modifying mechanisms. However, the data on the use of these products is limited. Conclusion. Many obese people use dietary supplements for weight loss. To date, there is little clinical evidence to support their use. More data is necessary to determine the efficacy and safety of these supplements. Healthcare providers should assist patients in weighing the risks and benefits of dietary supplement use for weight loss. PMID:20847896

  15. Pharmaceutical applications and phytochemical profile of Cinnamomum burmannii

    PubMed Central

    Al-Dhubiab, Bandar E.

    2012-01-01

    Extensive studies have been carried out in the last decade to assess the pharmaceutical potential and screen the phytochemical constituents of Cinnamomum burmannii. Databases such as PubMed (MEDLINE), Science Direct (Embase, Biobase, biosis), Scopus, Scifinder, Google Scholar, Google Patent, Cochrane database, and web of science were searched using a defined search strategy. This plant is a member of the genus Cinnamomum and is traditionally used as a spice. Cinnamomum burmannii have been demonstrated to exhibit analgesic, antibacterial, anti-diabetic, anti-fungal, antioxidant, antirheumatic, anti-thrombotic, and anti-tumor activities. The chemical constituents are mostly cinnamyl alcohol, coumarin, cinnamic acid, cinnamaldehyde, anthocynin, and essential oils together with constituents of sugar, protein, crude fats, pectin, and others. This review presents an overview of the current status and knowledge on the traditional usage, the pharmaceutical, biological activities, and phytochemical constituents reported for C. burmannii. PMID:23055638

  16. Preventive Treatments of Iron Deficiency Anaemia in Pregnancy: A Review of Their Effectiveness and Implications for Health System Strengthening

    PubMed Central

    Osungbade, Kayode O.; Oladunjoye, Adeolu O.

    2012-01-01

    Objectives. We conducted a review of effectiveness of preventive treatments of iron deficiency anaemia in pregnancy in developing countries and highlighted their constraints as well as interventions required to strengthen the health services. Methods. Literature from Pubmed (MEDLINE), AJOL, Google Scholar, and Cochrane database was reviewed. Results. Evidence-based preventive treatment options for iron deficiency anaemia in pregnancy include prophylaxis iron supplements and food fortification with iron. Evidence abounds on their effectiveness in reducing the prevalence of iron deficiency anaemia in pregnancy. However, these prospects are threatened by side effects of iron supplements, low utilization of maternal health service in developing countries, partial implementation of preventive treatments, and weak infrastructure and political commitment to implement mass fortification of local staple foods by national governments. Conclusion. Sustainability of effectiveness of preventive treatments of iron deficiency anaemia in pregnancy could be achieved if the identified threats are adequately addressed. PMID:22848829

  17. Interruptions of nurses' activities and patient safety: an integrative literature review1

    PubMed Central

    Monteiro, Cintia; Avelar, Ariane Ferreira Machado; Pedreira, Mavilde da Luz Gonçalves

    2015-01-01

    OBJECTIVES: to identify characteristics related to the interruption of nurses in professional practice, as well as to assess the implications of interruptions for patient safety. METHOD: integrative literature review. The following databases were searched: Pubmed/Medline, LILACS, SciELO and Cochrane Library, using the descriptors interruptions and patient safety. An initial date was not established, but the final date was December 31, 2013. A total of 29 papers met the inclusion criteria. RESULTS: all the papers included describe interruptions as a harmful factor for patient safety. Data analysis revealed three relevant categories: characteristics of interruptions, implications for patient safety, and interventions to minimize interruptions. CONCLUSION: interruptions favor the occurrence of errors in the health field. Therefore, there is a need for further studies to understand such a phenomenon and its effects on clinical practice. PMID:25806646

  18. Acupuncture for patients with Alzheimer's disease: a systematic review protocol

    PubMed Central

    Zhou, Jing; Peng, Weina; Li, Wang; Liu, Zhishun

    2014-01-01

    Introduction The aim of this protocol is to provide the methods used to assess the effectiveness and safety of acupuncture for the treatment of patients with Alzheimer's disease. Methods and analysis We will search the following electronic databases: The Cochrane Library, PubMed, Medline, Embase, PsycINFO, Chinese Biomedical Literature Database, Chinese Medical Current Contents and China National Knowledge Infrastructure without restriction of language and publication status. Other sources such as Chinese acupuncture journals and the reference list of selected studies will also be searched. After screening the studies, a meta-analysis of randomised controlled trials will be conducted, if possible. Results expressed as risk ratios for dichotomous data and standardised or weighted mean differences for continuous data, will be used for data synthesis. Dissemination The protocol of this systematic review will be disseminated in a peer-reviewed journal and presented at a relevant conference. Trial registration number PROSPERO CRD42014009619 PMID:25142265

  19. Application of Low Frequency and Medium Frequency Currents in the Management of Acute and Chronic Pain-A Narrative Review

    PubMed Central

    Samuel, Stephen Rajan; Maiya, G Arun

    2015-01-01

    Trancutaneous electrical nerve stimulation (TENS) and interferential therapy (IFT) have been a regular line of treatment for various types of acute and chronic pain. This review aims to compile the latest literature in pain management using these modalities which use low-frequency and medium-frequency currents. The Cochrane Library, Scopus, PubMed, MEDLINE, and CINAHL were searched and studies were examined from their inception till October 2013. After title and abstract screening the relevant studies were included for this review. We found through this review that even though TENS and IFT are used in management of pain, there is limited amount of high quality research available in this area. Most of the studies lack methodological quality and have a low sample size. PMID:25709199

  20. Epidemiological aspects of rheumatoid arthritis patients affected by oral bisphosphonate-related osteonecrosis of the jaws

    PubMed Central

    2012-01-01

    This literature review aims to evaluate the epidemiologic profile of patients with rheumatoid arthritis (RA) that developed a bisphosphonate-related osteonecrosis that affect the jaws (BRONJ), including demographic aspects, as well as clinical and therapeutic issues. A search of PUBMED/MEDLINE, Scopus, and Cochrane databases from January 2003 to September 2011 was conducted with the objective of identifying publications that contained case reports regarding oral BRONJ in RA patients. Patients with RA who develop oral BRONJ are usually women above 60 years taking steroids and long-term alendronate. Most of them have osteoporosis, and lesions, triggered by dental procedures, are usually detected at stage II in the mandible. Although there is no accepted treatment protocol, these patients seem to have better outcomes with conservative approaches that include antibiotic therapy, chlorhexidine, and drug discontinuation. PMID:22376948

  1. Pharmacokinetic drug-drug interaction and their implication in clinical management

    PubMed Central

    Palleria, Caterina; Di Paolo, Antonello; Giofrè, Chiara; Caglioti, Chiara; Leuzzi, Giacomo; Siniscalchi, Antonio; De Sarro, Giovambattista; Gallelli, Luca

    2013-01-01

    Drug-drug interactions (DDIs) are one of the commonest causes of medication error in developed countries, particularly in the elderly due to poly-therapy, with a prevalence of 20-40%. In particular, poly-therapy increases the complexity of therapeutic management and thereby the risk of clinically important DDIs, which can both induce the development of adverse drug reactions or reduce the clinical efficacy. DDIs can be classify into two main groups: pharmacokinetic and pharmacodynamic. In this review, using Medline, PubMed, Embase, Cochrane library and Reference lists we searched articles published until June 30 2012, and we described the mechanism of pharmacokinetic DDIs focusing the interest on their clinical implications. PMID:24516494

  2. MedlinePlus FAQ: What is MedlinePlus?

    MedlinePLUS

    ... brings health consumers an extensive library of medical images and videos , as well as over 4,000 articles about diseases, tests, symptoms, injuries, and surgeries. The Merriam-Webster medical dictionary allows you to look up definitions and spellings of medical words. Drug and supplement ...

  3. An assessment of the efficacy of searching in biomedical databases beyond MEDLINE in identifying studies for a systematic review on ward closures as an infection control intervention to control outbreaks

    PubMed Central

    2014-01-01

    Background The purpose of our study is to determine the value and efficacy of searching biomedical databases beyond MEDLINE for systematic reviews. Methods We analyzed the results from a systematic review conducted by the authors and others on ward closure as an infection control practice. Ovid MEDLINE including In-Process & Other Non-Indexed Citations, Ovid Embase, CINAHL Plus, LILACS, and IndMED were systematically searched for articles of any study type discussing ward closure, as were bibliographies of selected articles and recent infection control conference abstracts. Search results were tracked, recorded, and analyzed using a relative recall method. The sensitivity of searching in each database was calculated. Results Two thousand ninety-five unique citations were identified and screened for inclusion in the systematic review: 2,060 from database searching and 35 from hand searching and other sources. Ninety-seven citations were included in the final review. MEDLINE and Embase searches each retrieved 80 of the 97 articles included, only 4 articles from each database were unique. The CINAHL search retrieved 35 included articles, and 4 were unique. The IndMED and LILACS searches did not retrieve any included articles, although 75 of the included articles were indexed in LILACS. The true value of using regional databases, particularly LILACS, may lie with the ability to search in the language spoken in the region. Eight articles were found only through hand searching. Conclusions Identifying studies for a systematic review where the research is observational is complex. The value each individual study contributes to the review cannot be accurately measured. Consequently, we could not determine the value of results found from searching beyond MEDLINE, Embase, and CINAHL with accuracy. However, hand searching for serendipitous retrieval remains an important aspect due to indexing and keyword challenges inherent in this literature. PMID:25387523

  4. Search terms and a validated brief search filter to retrieve publications on health-related values in Medline: a word frequency analysis study

    PubMed Central

    Sutcliffe, Paul; Fulford, K W M (Bill); Dale, Jeremy

    2011-01-01

    Objective Healthcare debates and policy developments are increasingly concerned with a broad range of values-related areas. These include not only ethical, moral, religious, and other types of values ‘proper’, but also beliefs, preferences, experiences, choices, satisfaction, quality of life, etc. Research on such issues may be difficult to retrieve. This study used word frequency analysis to generate a broad pool of search terms and a brief filter to facilitate relevant searches in bibliographic databases. Methods Word frequency analysis for ‘values terms’ was performed on citations on diabetes, obesity, dementia, and schizophrenia (Medline; 2004–2006; 4440 citations; 1?110?291 words). Concordance® and SPSS 14.0 were used. Text words and MeSH terms of high frequency and precision were compiled into a search filter. It was validated on datasets of citations on dentistry and food hypersensitivity. Results 144 unique text words and 124 unique MeSH terms of moderate and high frequency (?20) and very high precision (?90%) were identified. Of these, 19 text words and seven MeSH terms were compiled into a ‘brief values filter’. In the derivation dataset, it had a sensitivity of 76.8% and precision of 86.8%. In the validation datasets, its sensitivity and precision were, respectively, 70.1% and 63.6% (food hypersensitivity) and 47.1% and 82.6% (dentistry). Conclusions This study provided a varied pool of search terms and a simple and highly effective tool for retrieving publications on health-related values. Further work is required to facilitate access to such research and enhance its chances of being translated into practice, policy, and service improvements. PMID:21846778

  5. Articles about MedlinePlus

    MedlinePLUS

    ... nih.gov/pmc/articles/PMC1773045/ . Miller N, Lacroix EM, Backus JEB. MEDLINEplus: building and maintaining the National ... nz/journal/1001 . Wood FB, Benson D, LaCroix EM, Siegel ER, Fariss S. Use of internet audience measurement ...

  6. Contact Us: MedlinePlus

    MedlinePLUS

    ... Congo, Democratic Republic ofCook IslandsCosta RicaCroatia Local Name:(Hrvatska)CubaCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEstoniaEthiopiaFalkland Islands (Malvinas)FijiFinlandFranceFrench GuianaFrench ...

  7. MedlinePlus: Mental Health

    NSDL National Science Digital Library

    MedLinePlus is a joint collaboration between the U.S. National Library of Medicine and the National Institutes of Health which has received strong marks during the past few years for providing high-quality health-related materials to the Web-browsing public. This particular area of the MedLinePlus site is devoted to providing materials about mental health. Here visitors can learn about various related topics by browsing through the top-level sections that include Alternative Therapy, Coping, and Nutrition. Within each area, visitors will be directed to links provided by a host of sources, including the Mayo Foundation, the Surgeon General, the American Psychiatric Association, and a number of other reputable institutions. The News section is also a fine way to keep abreast of recent developments in the field of mental health, as it culls news releases from some of the major international press agencies.

  8. Surgery Videos: MedlinePlus

    MedlinePLUS Videos and Cool Tools

    ... Medical Center, Fort Lauderdale, FL, 12/06/2011) Digestive System Anal Disorders Anal Fistula Plug (Cook Surgical, Atlanta, GA, 11/30/2005) Bile Duct Cancer Diagnosing & Treating Digestive Tract Disorders Endoscopically (Wake Forest University Baptist Medical ...

  9. Anatomy Videos: MedlinePlus

    MedlinePLUS Videos and Cool Tools

    ... M. is also a founding member of Hi-Ethics and subscribes to the principles of the Health on the Net Foundation (www.hon.ch). The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of ...

  10. MedlinePlus FAQ: MedlinePlus and MEDLINE/PubMed

    MedlinePLUS

    ... on over 900 health topics , as well as dictionaries, directories, organizations, and news stories. Provides access to ... A.M. Medical Encyclopedia The Merriam-Webster Medical Dictionary Information on prescription drugs and over-the-counter ...

  11. Library Resources

    Cancer.gov

    Library Resources Literature Search via PubMed NOTE: PubMed replaces Entrez (previously limited to Molecular Biology references in Medline). Searches are now free, with no account required, either for Grateful Med or PubMed. National Library of Medicine NIH

  12. bibliographique avec PubMed/MedLine

    E-print Network

    Jeanjean, Louis

    , ... Références d'article : + de 20 millions (~81% ont un résumé) Plus de 5000 titres dépouillés en 2010 · Medline'articles médicaux avec PubMed puis d'accéder au texte intégral. Cela se traduit par : Savoir interroger MedLine avec. Chattot, A. Pelé, A Tramut - BU Médecine - Besançon 2010 3 Plan 1. MedLine avec PubMed 2. Base REVUES #12

  13. Isolated patellofemoral osteoarthritis

    PubMed Central

    Poolman, Rudolf W; van Kampen, Albert

    2010-01-01

    Background and purpose The optimal treatment for isolated patellofemoral osteoarthritis is unclear at present. We systematically reviewed the highest level of available evidence on the nonoperative and operative treatment of isolated patellofemoral osteoarthritis to develop an evidenced-based discussion of treatment options. Methods A systematic computerized database search (Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, MEDLINE (PubMed), and EMBASE) was performed in March 2009. The quality of the studies was assessed independently by two authors using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Results We extracted data from 44 articles. The best available evidence for treatment of isolated patellofemoral osteoarthritis is sparse and of generally low methodological quality. Nonoperative treatment using physiotherapy (GRADE: high quality, weak recommendation for use), taping (GRADE: moderate quality, weak recommendation for use), or injection therapy (GRADE: very low quality, weak recommendation for use) may result in short-term relief. Joint-preserving surgical treatment may result in insufficient, unpredictable, or only short-term improvement (GRADE: low quality, weak recommendation against use). Total knee replacement with patellar resurfacing results in predictable and good, durable results (GRADE: low quality, weak recommendation for use). Outcome after patellofemoral arthroplasty in selected patients is good to excellent (GRADE: low quality, weak recommendation for use). Interpretation Methodologically good quality comparative studies, preferably using a patient-relevant outcome instrument, are needed to establish the optimal treatment strategy for patients with isolated patellofemoral osteoarthritis. PMID:20175647

  14. The effectiveness of opioid substitution treatments for patients with opioid dependence: a systematic review and multiple treatment comparison protocol

    PubMed Central

    2014-01-01

    Background Opioids are psychoactive analgesic drugs prescribed for pain relief and palliative care. Due to their addictive potential, effort and vigilance in controlling prescriptions is needed to avoid misuse and dependence. Despite the effort, the prevalence of opioid use disorder continues to rise. Opioid substitution therapies are commonly used to treat opioid dependence; however, there is minimal consensus as to which therapy is most effective. Available treatments include methadone, heroin, buprenorphine, as well as naltrexone. This systematic review aims to assess and compare the effect of all available opioid substitution therapies on the treatment of opioid dependence. Methods/Design The authors will search Medline, EMBASE, PubMed, PsycINFO, Web of Science, Cochrane Library, Cochrane Clinical Trials Registry, World Health Organization International Clinical Trials Registry Platform Search Portal, and the National Institutes for Health Clinical Trials Registry. The title, abstract, and full-text screening will be completed in duplicate. When appropriate, multiple treatment comparison Bayesian meta-analytic methods will be performed to deduce summary statistics estimating the effectiveness of all opioid substitution therapies in terms of retention and response to treatment (as measured through continued opioid abuse). Discussion Using evidence gained from this systematic review, we anticipate disseminating an objective review of the current available literature on the effectiveness of all opioid substitution therapies for the treatment of opioid use disorder. The results of this systematic review are imperative to the further enhancement of clinical practice in addiction medicine. Systematic review registration PROSPERO CRD42013006507. PMID:25239213

  15. Definitions and outcome measures of clinical trials regarding opioid-induced constipation: a systematic review.

    PubMed

    Gaertner, Jan; Siemens, Waldemar; Camilleri, Michael; Davies, Andrew; Drossman, Douglas A; Webster, Lynn R; Becker, Gerhild

    2015-01-01

    Opioid-induced constipation (OIC) is a frequent symptom in patients treated with opioids and impacts the patients' quality of life. However, there is no generally accepted definition for OIC. The aims of this study were to identify definitions for OIC in clinical trials and Cochrane Reviews and to compile assessment tools and outcome measures that were used in clinical trials. In a systematic review, 5 databases (MEDLINE, PubMed, The Cochrane Library, Web of Science, and EMBASE) were searched to identify clinical trials assessing OIC in adult patients or healthy volunteers. Studies published between 1993 and August 2013 were included. A total of 1488 studies were retrieved and 47 publications were included in the analysis. A minority of the publications (n=16, 34%) provided a clear definition for OIC. The definitions were highly variable and the present or recent history of opioid therapy was frequently (n=6, 38%) not included in these definitions. Of 46 clinical trials, 17 (37%) relied exclusively on objective measures such as bowel movement frequency, whereas another 17 studies additionally included patient-reported outcome measures such as, "feeling of incomplete bowel evacuation." Few trials (n=7, 15%) assessed the patient-reported global burden of OIC. Standard definitions and outcome measures are necessary (i) for consistency in OIC diagnosis in clinical practice and clinical trials; and (ii) to assure comparability of trial findings (eg, in meta-analyses). An OIC definition and outcome measures are proposed. PMID:25356996

  16. Sexual and gender-based violence in areas of armed conflict: a systematic review of mental health and psychosocial support interventions

    PubMed Central

    2013-01-01

    Background Sexual and other forms of gender-based violence are common in conflict settings and are known risk factors for mental health and psychosocial wellbeing. We present findings from a systematic review of the academic and grey literature focused on the effectiveness of mental health and psychosocial support interventions for populations exposed to sexual and other forms of gender-based violence in the context of armed conflicts. Methods We searched the Cochrane Database of Systematic Reviews, Cochrane Controlled Trials Register, PubMed/ Medline, psycINFO, and PILOTS, as well as grey literature to search for evaluations of interventions, without date limitations. Results Out of 5,684 returned records 189 full text papers were assessed for eligibility. Seven studies met inclusion criteria: 1 non-randomized controlled study; 3 non-controlled pre- post-test designs; 1 retrospective cohort with a matched comparison group; and 2 case studies. Studies were conducted in West and Central Africa; Albania; UK and USA, included female participants, and focused on individual and group counseling; combined psychological, medical, social and economic interventions; and cognitive behavioral therapy (two single case studies). Conclusions The seven studies, while very limited, tentatively suggest beneficial effects of mental health and psychosocial interventions for this population, and show feasibility of evaluation and implementation of such interventions in real-life settings through partnerships with humanitarian organizations. Robust conclusions on the effectiveness of particular approaches are not possible on the basis of current evidence. More rigorous research is urgently needed. PMID:23915821

  17. Malignant transformation of hepatocellular adenomas into hepatocellular carcinomas: a systematic review including more than 1600 adenoma cases

    PubMed Central

    Stoot, Jan HMB; Coelen, Robert JS; de Jong, Mechteld C; Dejong, Cornelis HC

    2010-01-01

    Background Malignant transformation of hepatocellular adenomas (HCAs) into hepatocellular carcinomas (HCCs) has been reported repeatedly and is considered to be one of the main reasons for surgical treatment. However, its actual risk is currently unknown. Objective To provide an estimation of the frequency of malignant transformation of HCAs and to discuss its clinical implications. Methods A systematic literature search was conducted using the following databases: The Cochrane Hepatobiliary Group Controlled Trials Register, The Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, MEDLINE and EMBASE. Results One hundred and fifty-seven relevant series and 17 case reports (a total of 1635 HCAs) were retrieved, reporting an overall frequency of malignant transformation of 4.2%. Only three cases (4.4%) of malignant alteration were reported in a tumour smaller than 5 cm in diameter. Discussion Malignant transformation of HCAs into HCCs remains a rare phenomenon with a reported frequency of 4.2%. A better selection of exactly those patients presenting with an HCA with an amplified risk of malignant degeneration is advocated in order to reduce the number of liver resections and thus reducing the operative risk for these predominantly young patients. The Bordeaux adenoma tumour markers are a promising method of identifying these high-risk adenomas. PMID:20887318

  18. Describing methods and interventions: a protocol for the systematic analysis of the perioperative quality improvement literature

    PubMed Central

    2014-01-01

    Background Quality improvement (QI) methods are widely used in surgery in an effort to improve care, often using techniques such as Plan-Do-Study-Act cycles to implement specific interventions. Explicit definition of both the QI method and quality intervention is necessary to enable the accurate replication of effective interventions in practice, facilitate cumulative learning, reduce research waste and optimise benefits to patients. This systematic review aims to assess quality of reporting of QI methods and quality interventions in perioperative care. Methods Studies reporting on quality interventions implemented in perioperative care settings will be identified. Searches will be conducted in the Ovid SP version of Medline, Scopus, the Cochrane Central Register of Controlled Trials, the Cochrane Effective Practice and Organisation of Care database and the related articles function of PubMed. The journal BMJ Quality will be searched separately. Search strategy terms will relate to (i) surgery, (ii) QI and (iii) evaluation methods. Explicit exclusion and inclusion criteria will be applied. Data from studies will be extracted using a data extraction form. The Template for Intervention Description and Replication (TIDieR) checklist will be used to evaluate quality of reporting, together with additional items aimed at assessing QI methods specifically. Systematic review registration PROSPERO http://CRD42014012845 PMID:25193066

  19. New approach to managing genital warts

    PubMed Central

    Lopaschuk, Catharine C.

    2013-01-01

    Abstract Objective To summarize and determine the appropriate use for the new and old management tools for genital warts. Sources of information The following databases were searched: MEDLINE, PubMed, EMBASE, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, ACP Journal Club, and Trip. The bibliographies of retrieved papers were also reviewed. Clinical trials, qualitative review articles, consensus reports, and clinical practice guidelines were retrieved. Main message Symptomatic warts are prevalent in at least 1% of the population between the ages of 15 and 49, with estimates of up to 50% of the population being infected with human papillomavirus at some point in their lifetime. Imiquimod and podophyllotoxin are 2 new treatments for external genital warts that are less painful and can be applied by patients at home. In addition, the quadrivalent human papillomavirus vaccine has been shown to be efficacious in preventing genital warts and cervical cancer. There is still a role for the older treatment methods in certain situations, such as intravaginal, urethral, anal, or recalcitrant warts; or for pregnant patients. Conclusion The new treatments of external genital warts can reduce the pain of treatment and the number of office visits. Other treatment methods are still useful in certain situations. PMID:23851535

  20. The Anxiolytic Effect of Midazolam in Third Molar Extraction: A Systematic Review

    PubMed Central

    Chen, Qi; Wang, Lufei; Ge, Lina; Gao, Yuan; Wang, Hang

    2015-01-01

    Purpose To assess the efficacy of midazolam for anxiety control in third molar extraction surgery. Methods Electronic retrievals were conducted in Medline (via PubMed, 1950-2013.12), the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2013, Issue 3), Embase (via OVID 1974-2013.12), and the System for Information on Grey Literature in Europe (SIGLE). The bibliographies of relevant clinical trials were also checked. Randomized controlled trials satisfying the inclusion criteria were evaluated, with data extraction done independently by two well-trained investigators. Disagreements were resolved by discussion or by consultation with a third member of the review team. Results Ten studies were included, but meta-analysis could not be conducted because of the significant differences among articles. All but one article demonstrated that midazolam could relieve anxiety. One article demonstrated that propofol offered superior anxiolysis, with more rapid recovery than with midazolam. Compared with lorazepam and diazepam, midazolam did not distinctly dominate in its sedative effect, but was safer. Two articles used midazolam in multidrug intravenous sedation and proved it to be more effective than midazolam alone. Conclusion It was found, by comparison and analysis, that midazolam might be effective for use for anxiety control during third molar extraction and can be safely administered by a dedicated staff member. It can also be used with other drugs to obtain better sedative effects, but the patient’s respiratory function must be monitored closely, because multidrug sedation is also more risky. PMID:25849859

  1. Interventions to support children’s engagement in health-related decisions: a systematic review

    PubMed Central

    2014-01-01

    Background Children often need support in health decision-making. The objective of this study was to review characteristics and effectiveness of interventions that support health decision-making of children. Methods A systematic review. Electronic databases (PubMed, the Cochrane Library, Web of Science, Scopus, ProQuest Dissertations and Theses, CINAHL, PsycINFO, MEDLINE, and EMBASE) were searched from inception until March 2012. Two independent reviewers screened eligibility: a) intervention studies; b) involved supporting children (?18 years) considering health-related decision(s); and c) measured decision quality or decision-making process outcomes. Data extraction and quality appraisal were conducted by one author and verified by another using a standardized data extraction form. Quality appraisal was based on the Cochrane Risk of Bias tool. Results Of 4313 citations, 5 studies were eligible. Interventions focused on supporting decisions about risk behaviors (n?=?3), psycho-educational services (n?=?1), and end of life (n?=?1). Two of 5 studies had statistically significant findings: i) compared to attention placebo, decision coaching alone increased values congruence between child and parent, and child satisfaction with decision-making process (lower risk of bias); ii) compared to no intervention, a workshop with weekly assignments increased overall decision-making quality (higher risk of bias). Conclusions Few studies have focused on interventions to support children’s participation in decisions about their health. More research is needed to determine effective methods for supporting children’s health decision-making. PMID:24758566

  2. The effectiveness of middle and high school-based suicide prevention programmes for adolescents: a systematic review

    Microsoft Academic Search

    Michael D Cusimano; Mojib Sameem

    2010-01-01

    ObjectiveTo assess the effectiveness of middle and high school-based suicide prevention curricula.Data sourcesThe following were searched: Ovid MEDLINE(R) in-process and other non-indexed citations and Ovid MEDLINE(R), Ovid Healthstar, CINAHL, PsycINFO, all EBM reviews—Cochrane DSR, ACP Journal Club, DARE, CCTR, CMR, HTA, and NHSEED, and the ISI Web of Science, until October 2009; government web pages for statistics and other demographic

  3. Effectiveness of an intervention for disseminating Cochrane Reviews to nurses.

    PubMed

    Oermann, Marilyn H; Roop, Janna C; Nordstrom, Cheryl K; Galvin, Elizabeth A; Floyd, Judith A

    2009-01-01

    Disseminating research findings to clinicians can be a challenging task. In this study, researchers tested the effectiveness of disseminating summaries of systematic reviews to clinicians. The findings suggest that these summaries are well-accepted by nurses and increase their knowledge of research findings. PMID:19331274

  4. Effectiveness of an intervention for disseminating Cochrane reviews to nurses.

    PubMed

    Oermann, Marilyn H; Roop, Janna C; Nordstrom, Cheryl K; Galvin, Elizabeth A; Floyd, Judith A

    2007-12-01

    Disseminating research findings to clinicians can be a challenging task. In this study, researchers tested the effectiveness of disseminating summaries of systematic reviews to clinicians. The findings suggest that these summaries are well-accepted by nurses and increase their knowledge of research findings. PMID:18390257

  5. Heparin for assisted reproduction: summary of a Cochrane review.

    PubMed

    Akhtar, Muhammad Ahsan; Sur, Shyamaly; Raine-Fenning, Nick; Jayaprakasan, Kannamannadiar; Thornton, Jim; Quenby, Siobhan; Marjoribanks, Jane

    2015-01-01

    It is suggested that heparin given in the peri-implantation period may improve clinical outcomes in women undergoing assisted reproduction techniques (ART). This systematic review evaluates the use of heparin in subfertile women undergoing ART. PMID:25282470

  6. Online Medical Literature Consultation Habits of Academic Teaching Physicians in the EU and CIS Countries: A Cross-Sectional Study

    PubMed Central

    van der Voort, Chiel T. M.; Swenne, Cees A.; van der Hoorn-van Velthoven, Catharina A. M.; Belt, Johannes H. J.

    2012-01-01

    Background Both in the Commonwealth of Independent States (CIS) and in the European Union (EU2004), ample availability of up to date medical scientific literature is important for progress in medical science and for the education of the next generation of healthcare workers. The aim of this research is to assess if the use of online medical literature among academic teaching (AT) physicians is at the same level in the CIS as in the EU2004. Methodology/Principal Findings In the capital cities of the CIS and the EU2004 member states, AT physicians holding an academic position at least equivalent to an associate professor and performing the three classical tasks in academic medicine (teaching, research and patient care) were interviewed about their use of and familiarity with the Internet and 9 online literature services, including journals and bibliographical databases such as PubMed (Medline), The Cochrane Library and Web of Science. Library staff members were interviewed about the availability of these online literature services at their libraries. About 750 physicians and 40 library staff members were invited for participation. Eventually 124 AT physicians and 22 library staff members participated. Internet was everywhere available, but used daily by more AT physicians in the EU2004 (71% versus 48% in the CIS, P?=?.005). AT physicians in the EU2004 accessed a higher percentage of all articles online (74% versus 43% in the CIS, P<.001). PubMed (P<.001), The Cochrane Library (P<.001) and Web of Science (P<.003) were used more frequently in the EU2004. In the EU2004 more AT physicians were familiar with Open Access journals (89% versus 51% in the CIS, P<.001). Conclusions/Significance AT physicians in the CIS use online medical literature less than in the EU2004. It is recommended that the awareness of freely available online literature services such as Open Access journals is enhanced among AT physicians and library staff members, especially in the CIS. PMID:23133588

  7. Malignant pleural effusions and the role of talc poudrage and talc slurry: a systematic review and meta-analysis

    PubMed Central

    Mummadi, Srinivas; Kumbam, Anusha; Hahn, Peter Y.

    2015-01-01

    Background: Malignant Pleural Effusion (MPE) is common with advanced malignancy. Palliative care with minimal adverse events is the cornerstone of management. Although talc pleurodesis plays an important role in treatment, the best modality of talc application remains controversial.   Objective: To compare rates of successful pleurodesis, rates of respiratory and non-respiratory complications between thoracoscopic talc insufflation/poudrage (TTI) and talc slurry (TS).  Data sources and study selection: MEDLINE (PubMed, OVID),  EBM Reviews (Cochrane database of Systematic Reviews, ACP Journal Club, DARE, Cochrane Central Register of Controlled Trials, Cochrane Methodology Register, Health Technology Assessment and NHS Economic Evaluation Database), EMBASE and Scopus. Randomized controlled trials published between 01/01/1980 - 10/1/2014 and comparing the two strategies were selected.  Results: Twenty-eight potential studies were identified of which 24 studies were further excluded, leaving four studies. No statistically significant difference in the probability of successful pleurodesis was observed between TS and TTI groups (RR 1.06; 95 % CI 0.99-1.14; Q statistic, 4.84). There was a higher risk of post procedural respiratory complications in the TTI group compared to the TS group (RR 1.91, 95% CI= 1.24-2.93, Q statistic 3.15). No statistically significant difference in the incidence of non-respiratory complications between the TTI group and the TS group was observed (RR 0.88, 95% CI= 0.72-1.07, Q statistic 4.61). Conclusions: There is no difference in success rates of pleurodesis based on patient centered outcomes between talc poudrage and talc slurry treatments.  Respiratory complications are more common with talc poudrage via thoracoscopy.

  8. Should we advise parents to administer over the counter cough medicines for acute cough? Systematic review of randomised controlled trials

    Microsoft Academic Search

    K Schroeder; T Fahey

    2002-01-01

    Aims: To determine the effectiveness of over the counter (OTC) cough medicines for acute cough in children.Methods: Systematic review of randomised controlled trials (RCTs). An all language search of the Cochrane Acute Respiratory Infections Group specialised register, Cochrane Controlled Trials Register, Medline, Embase, and the UK Department of Health National Research Register was performed. RCTs comparing oral OTC cough preparations

  9. Preventing occupational stress in healthcare workers

    Microsoft Academic Search

    A. Marine; J. Ruotsalainen; C. Serra; J. H. A. M. Verbeek

    2006-01-01

    Background Healthcare workers can suffer from occupational stress which may lead to serious mental and physical health problems. Objectives To evaluate the effectiveness of work and person-directed interventions in preventing stress at work in healthcare workers. Search strategy We searched the Cochrane Depression Anxiety and Neurosis Group trials Specialised Register, MEDLINE, PsychInfo and Cochrane Occupational Health Field database. Selection criteria

  10. The impact of physical therapy on functional outcomes after stroke: what's the evidence?

    Microsoft Academic Search

    R PS Van Peppen; G Kwakkel; S Wood-Dauphinee; H JM Hendriks; Ph J Van der Wees; J Dekker

    2004-01-01

    Objective: To determine the evidence for physical therapy interventions aimed at improving functional outcome after stroke.Methods: MEDLINE, CINAHL, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, DARE, PEDro, EMBASE and DocOnline were searched for controlled studies. Physical therapy was divided into 10 intervention categories, which were analysed separately. If statistical pooling (weighted summary effect sizes) was not

  11. Effects of treatment for intestinal helminth infection on growth and cognitive performance in children: systematic review of randomised trials

    Microsoft Academic Search

    Rumona Dickson; Shally Awasthi; Paula Williamson; Colin Demellweek; Paul Garner

    2000-01-01

    Objective To summarise the effects of anthelmintic drug treatment on growth and cognitive performance in children. Data sources Electronic databases: Cochrane Infectious Diseases Group controlled trial register, Cochrane controlled trials register, Embase, and Medline. Citations of all identified trials. Contact with the World Health Organization and field researchers. Review methods Systematic review of randomised controlled trials in children aged 1›16

  12. Insufficient evidence to support or refute the need for 6-monthly dental check-ups. What is the optimal recall frequency between dental checks?

    Microsoft Academic Search

    Th. G. P. H. Mettes

    2005-01-01

    DATA SOURCES: Trials were sourced using the Cochrane Oral Health Group Trials Register, the Cochrane Central Register of Controlled Trials, Medline and Embase. Reference lists from relevant articles were scanned and the authors of some papers were contacted to identify further trials and obtain additional information. STUDY SELECTION: Trials were selected if they met the following criteria:design: random allocation of

  13. Use of autologous fat grafting for reconstruction postmastectomy and breast conserving surgery: a systematic review protocol

    PubMed Central

    Agha, Riaz A; Goodacre, Tim; Orgill, Dennis P

    2013-01-01

    Introduction There is growing interest in the potential use of autologous fat grafting (AFG) for the purposes of breast reconstruction. However, concerns have been raised regarding the technique's clinical effectiveness, safety and interference with screening mammography. The objective of this systematic review was to determine the oncological, clinical, aesthetic and functional, patient reported, process and radiological outcomes for AFG. Methods and analysis All original studies, including randomised controlled trials, cohorts studies, case–control studies, case series and case reports involving women undergoing breast reconstruction. All AFG techniques performed for the purposes of reconstruction in the postmastectomy or breast conserving surgery setting will be considered. Outcomes are defined within this protocol along; oncological, clinical, aesthetic and functional, patient reported, process and radiological domains. The search strategy has been devised to find papers about ‘fat grafting and breast reconstruction’ and is outlined within the body of this protocol. The full search strategy is outlined within the body of the protocol. The following electronic databases will be searched from 1 January 1986 to 6 June 2013: PubMed, MEDLINE, EMBASE, SCOPUS, CINAHL, PsycINFO, SciELO, The Cochrane Library, including the Cochrane Database of Systematic Reviews (CDSR), Cochrane Central Register of Controlled Trials (CENTRAL), Database of Abstracts of Reviews of Effect (DARE), the Cochrane Methodology Register, Health Technology Assessment Database, the NHS Economic Evaluation Databases and Cochrane Groups, ClinicalTrials.gov, Current Controlled Trials Database, the World Health Organisation (WHO) International Clinical Trials Registry Platform, UpToDate.com, NHS Evidence and the York Centre for Reviews and Dissemination. Grey literature searches will also be conducted as detailed in our review protocol. Eligibility assessment occurred in two stages, title and abstract screening and then full text assessment. Data were extracted and stored in a database with standardised extraction fields to facilitate easy and consistent data entry. Ethics and dissemination This systematic review will be published in a peer-reviewed journal. It will also be presented at national and international conferences in the fields of plastic, reconstructive and aesthetic surgery and at more general surgical and methodological conferences. It will be disseminated electronically and in print. Brief reports of the review findings will be disseminated directly to the appropriate audiences of surgeons and societies through email and other modes of communication. Updates of the review will be conducted to inform and guide healthcare practice and policy. Protocol Registration PROSPERO—National Institute of Health Research (NIHR) Prospective Register of Systematic Reviews (CRD42013005254) PMID:24154518

  14. Comparison of Recovery Profile After Ambulatory Anesthesia with Propofol, Isoflurane, Sevoflurane and Desflurane: A Systematic Review

    Microsoft Academic Search

    Anil Gupta; Tracey Stierer; Rhonda Zuckerman; Neal Sakima; Stephen D. Parker; Lee A. Fleisher

    2004-01-01

    In this systematic review we focused on postoperative recovery and complications using four different anes- thetic techniques. The database MEDLINE was searched via PubMed (1966 to June 2002) using the search words \\

  15. ArticleLinker ArticleLinker

    E-print Network

    Takada, Shoji

    (Free Article), Google : KULINE : : PubMed, Scopus, CiNii, Webcat Plus, Impact Factor, RefWorks ArticleDiscus, CAB Abstracts, Global Health, AGRIS, AGRICOLA, MEDLINE(Ovid ), Evidence Based Medicine Reviews, CINAHL

  16. CHAPITRE 1. REVUE CRITIQUE DE LA LITTERATURE

    E-print Network

    Paris-Sud XI, Université de

    Library of Medicine par le moteur de recherche Pubmed (Medline et Popline) et des Current Contents, nous a permis de recenser les études épidémiologiques et de santé publique les plus pertinentes en matière de

  17. Analyse des groupes de gnes co-exprims (AGGC) : un outil automatique pour l'interprtation de donnes de biopuces

    E-print Network

    Paris-Sud XI, Université de

    bibliographiques tels que des articles, corpus de documents, des abstraits etc.): Pubmed-Medline, Biosis, etc données etc. Plus de détailles en Brazma et al. (2001). Plusieurs approches statistiques et d'analyse de

  18. Phenylketonuria - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... sharing features on this page, please enable JavaScript. Phenylketonuria - Multiple Languages Arabic (???????) Spanish (español) Arabic (???????) Phenylketonuria or PKU English (Arabic) ???? ????? ??????? -- ??? ...

  19. Heart Attack - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... JavaScript. Heart Attack - Multiple Languages Arabic (???????) Bosnian (Bosanski) Chinese - Simplified (????) Chinese - Traditional (????) French (français) ... ?????? ??????? - ??????? Multimedia Patient Education Institute Bosnian (Bosanski) Heart Attack Sr?ani udar - Bosanski (Bosnian) Bilingual PDF ...

  20. COPD - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... enable JavaScript. COPD - Multiple Languages Arabic (???????) Bosnian (Bosanski) Chinese - Simplified (????) Chinese - Traditional (????) French (français) ... Arabic) ??????? Bilingual PDF Health Information Translations Bosnian (Bosanski) Chronic Obstructive Pulmonary Disease (COPD) Hroni?na opstruktivna plu?na ...

  1. Heart Failure - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Failure - Multiple Languages Amharic (amarunya) Arabic (???????) Bosnian (Bosanski) Chinese - Simplified (????) Chinese - Traditional (????) French (français) ... ????? - ??????? Bilingual PDF Health Information Translations Bosnian (Bosanski) Heart Failure Zatajenje srca - Bosanski (Bosnian) Bilingual PDF ...

  2. Blood Thinners - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... JavaScript. Blood Thinners - Multiple Languages Arabic (???????) Bosnian (Bosanski) Chinese - Simplified (????) French (français) Hindi (??????) ... ?????????? ????? - ??????? Multimedia Patient Education Institute Bosnian (Bosanski) Coumadin (Warfarin) Kumadin (Warfarin) - Bosanski (Bosnian) Bilingual PDF ...

  3. MRSA - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... enable JavaScript. MRSA - Multiple Languages Arabic (???????) Bosnian (Bosanski) Chinese - Simplified (????) Chinese - Traditional (????) French (français) ... ???????? ???????????? - ??????? Multimedia Patient Education ... (Bosanski) MRSA (Methicillin Resistant Staphylococcus Aureus) MRSA (meticilin rezistentni ...

  4. Angina - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... enable JavaScript. Angina - Multiple Languages Arabic (???????) Bosnian (Bosanski) Chinese - Simplified (????) Chinese - Traditional (????) French (français) ... ?????? ??????? - ??????? Multimedia Patient Education Institute Bosnian ... Angina Bosanski (Bosnian) Bilingual PDF Health Information Translations ...

  5. Drug Abuse - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... JavaScript. Drug Abuse - Multiple Languages Arabic (???????) Bosnian (Bosanski) Chinese - Simplified (????) Chinese - Traditional (????) French (français) ... Arabic) ??????? Bilingual PDF Health Information Translations Bosnian (Bosanski) Substance Abuse or Dependence Zloupotreba opojnih sredstava ili ...

  6. Fever - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... enable JavaScript. Fever - Multiple Languages Arabic (???????) Bosnian (Bosanski) Chinese - Simplified (????) French (français) Japanese (???) Korean ( ... Arabic) ??????? Bilingual PDF Health Information Translations Bosnian (Bosanski) Taking a Temperature Mjerenje temperature - Bosanski (Bosnian) Bilingual ...

  7. Pain - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... enable JavaScript. Pain - Multiple Languages Arabic (???????) Bosnian (Bosanski) Chinese - Simplified (????) Chinese - Traditional (????) French (français) ... ?? ????? - ??????? Multimedia Patient Education Institute Bosnian (Bosanski) About Your Pain O Vašem bolu - Bosanski (Bosnian) ...

  8. Children's Health - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... please enable JavaScript. Children's Health - Multiple Languages Bosnian (Bosanski) Spanish (español) Bosnian (Bosanski) Taking a Temperature Mjerenje temperature - Bosanski (Bosnian) Bilingual ...

  9. Hip Replacement - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... JavaScript. Hip Replacement - Multiple Languages Arabic (???????) Bosnian (Bosanski) Chinese - Simplified (????) Chinese - Traditional (????) French (français) ... Arabic) ??????? Bilingual PDF Health Information Translations Bosnian (Bosanski) Total Hip Replacement Potpuna zamjena kuka - Bosanski (Bosnian) ...

  10. Falls - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... enable JavaScript. Falls - Multiple Languages Arabic (???????) Bosnian (Bosanski) Chinese - Simplified (????) Chinese - Traditional (????) French (français) ... Arabic) ??????? Bilingual PDF Health Information Translations Bosnian (Bosanski) Preventing Falls in the Hospital Sprje?avanje padova u ...

  11. Joint Disorders - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... JavaScript. Joint Disorders - Multiple Languages Arabic (???????) Bosnian (Bosanski) Chinese - Simplified (????) Chinese - Traditional (????) French (français) ... ??????? - ??????? Bilingual PDF Health Information Translations Bosnian (Bosanski) Home Care After Total Joint Replacement Ku?na njega ...

  12. Head Lice - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... JavaScript. Head Lice - Multiple Languages Arabic (???????) Bosnian (Bosanski) Chinese - Simplified (????) Chinese - Traditional (????) French (français) ... ????? - ??????? Bilingual PDF Health Information Translations Bosnian (Bosanski) Head Lice Vaške - Bosanski (Bosnian) Bilingual PDF Health ...

  13. Kidney Failure - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... JavaScript. Kidney Failure - Multiple Languages Arabic (???????) Bosnian (Bosanski) Chinese - Simplified (????) Chinese - Traditional (????) French (français) ... ????? ?????? - ??????? Multimedia Patient Education Institute Bosnian (Bosanski) Kidney Failure Otkazivanje rada bubrega - Bosanski (Bosnian) Bilingual ...

  14. Cesarean Section - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... JavaScript. Cesarean Section - Multiple Languages Arabic (???????) Bosnian (Bosanski) Chinese - Traditional (????) Hindi (??????) Japanese (???) ... ??????? ???????? - ??????? Multimedia Patient Education Institute Bosnian (Bosanski) Your Recovery After Cesarean Birth Vaš Oporavak Nakon ...

  15. Lung Cancer - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... JavaScript. Lung Cancer - Multiple Languages Arabic (???????) Bosnian (Bosanski) Chinese - Simplified (????) Chinese - Traditional (????) French (français) ... ????? - ??????? Bilingual PDF Health Information Translations Bosnian (Bosanski) Lung Cancer Karcinom plu?a - Bosanski (Bosnian) Bilingual PDF ...

  16. Anemia - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... enable JavaScript. Anemia - Multiple Languages Arabic (???????) Bosnian (Bosanski) Chinese - Simplified (????) French (français) Hindi (??????) ... Arabic) ??????? Bilingual PDF Health Information Translations Bosnian (Bosanski) Anemia Anemija - Bosanski (Bosnian) Bilingual PDF Health Information ...

  17. Tutorials for Africa - Malaria: MedlinePlus

    MedlinePLUS

    Tutorials for Africa: Malaria In Uganda, the burden of malaria outranks that of all other diseases. This tutorial includes information about how malaria spreads, the importance of treatment and techniques for ...

  18. MedlinePlus Milestones: 1998-present

    MedlinePLUS

    ... Go Local sites: INHealthConnect serving Indiana, Go Local Massachusetts serving Massachusetts, and South Texas Go Local serving Southern Texas. Both INHealthConnect and Go Local Massachusetts are the first sites generated by NLM's new ...

  19. Endoscopy - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Arabic (???????) French (français) Japanese (???) Korean (???) Russian (???????) Somali (af Soomaali) Spanish (español) Ukrainian (??????????) ... Bilingual PDF Health Information Translations Return to top Russian (???????) Colonoscopy with Bowel Prep: Go-Lytely, Colyte, ...

  20. Smallpox - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... sharing features on this page, please enable JavaScript. Smallpox - Multiple Languages Amharic (amarunya) Hmong (Hmoob) Khmer (Khmer) ... Soomaali) Spanish (español) Vietnamese (Tiê?ng Viê?t) Amharic (amarunya) Smallpox English amarunya (Amharic) PDF Minnesota Department of Health ...

  1. Refractive Errors - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... sharing features on this page, please enable JavaScript. Refractive Errors - Multiple Languages Chinese - Simplified (????) Chinese - Traditional (????) Spanish (español) Chinese - Simplified (????) Nearsightedness (Myopia) English ?? - ???? (Chinese - Simplified) PDF Chinese Community ...

  2. Parasitic Diseases - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... español) Ukrainian (??????????) Arabic (???????) Stool Test for Ova and Parasite (O&P) (Arabic) ??????? Bilingual PDF ... Information Translations Chinese - Simplified (????) Stool Test for Ova and Parasite (O&P) ??????????(O&P) - ???? ( ...

  3. MedlinePlus.gov (@medlineplus) | Twitter

    MedlinePLUS

    ... users Verified account @ Verified account @ Language: English Bahasa Indonesia Bahasa Melayu ?eština Dansk Deutsch English UK Español ... Vodafone, O2 India 53000 Bharti Airtel, Videocon, Reliance Indonesia 89887 AXIS, 3, Telkomsel, Indosat, XL Axiata Italy ...

  4. Gout - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... sharing features on this page, please enable JavaScript. Gout - Multiple Languages Arabic (???????) Chinese - Simplified (????) Chinese - ... ???) Spanish (español) Vietnamese (Tiê?ng Viê?t) Arabic (???????) Gout English (Arabic) ???????? - ??????? Multimedia Patient Education Institute ...

  5. Medicines - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ???? (Chinese - Simplified) Bilingual PDF Health Information Translations Chinese - Traditional (????) Giving Medicine by Subcutaneous Injection ?????? - ???? (Chinese - Traditional) Bilingual ...

  6. Diabetes Medicines - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... features on this page, please enable JavaScript. Diabetes Medicines - Multiple Languages Arabic (???????) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) ...

  7. Postpartum Depression - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... features on this page, please enable JavaScript. Postpartum Depression - Multiple Languages Arabic (???????) Bosnian (Bosanski) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Japanese (???) Korean (???) Marshallese ( ...

  8. Chemical Emergencies - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Centers for Disease Control and Prevention Facts about Sulfur Mustard English ????????? - ???? (Chinese - Traditional) PDF Centers for ... Centers for Disease Control and Prevention Facts about Sulfur Mustard English À propos du gaz moutarde - français (French) ...

  9. NIH MedlinePlus Advisory Group

    MedlinePLUS

    ... Lung and Blood Institute Larry Thompson Director of Communications and Public Liaison National Human Genome Research Institute Natalie Zeigler Senior Content Strategist National Institute of Mental Health Mobile version Get email updates Subscribe to RSS Follow ...

  10. Hyperglycemia - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... sharing features on this page, please enable JavaScript. Hyperglycemia - Multiple Languages Chinese - Simplified (????) Chinese - Traditional (????) ... ????) Low Blood Sugar (Hypoglycemia) / High Blood Sugar (Hyperglycemia) English ????, ???? - ???? (Chinese - Simplified) PDF Chinese ...

  11. Lung Diseases - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Arabic (???????) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) ... Chinese Community Health Resource Center Return to top French (français) Bronchoscopy Bronchoscopie - français (French) Bilingual PDF Health ...

  12. Child Safety - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Languages Arabic (???????) Bosnian (Bosanski) Chinese - Simplified (????) French (français) Hindi (??????) Japanese (???) Korean (???) ... Bilingual PDF Health Information Translations Return to top French (français) Child Safety Checklist Liste de contrôle pour ...

  13. Neurologic Diseases - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... JavaScript. Neurologic Diseases - Multiple Languages Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) ... ???? (Chinese - Traditional) Bilingual PDF Health Information Translations French (français) ... EEG (Électroencéphalogramme) - français (French) Bilingual ...

  14. Prenatal Testing - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Arabic (???????) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) ... Bilingual PDF Health Information Translations Return to top French (français) AFP (Alpha-Fetoprotein) Test Test AFP (alpha- ...

  15. Flu - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Chinese - Simplified (????) Chinese - Traditional (????) Farsi (?????) French (français) Haitian Creole (Kreyol) Hindi (??????) Hmong ( ... Health - Seattle and King County Return to top French (français) Home Care for Pandemic Flu Soins à ...

  16. Allergy - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Multiple Languages Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) ... Chinese - Traditional) PDF Chinese Community Health Resource Center French (français) Allergies Allergies - français (French) Bilingual PDF Health ...

  17. Mobility Aids - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Arabic (???????) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) ... Bilingual PDF Health Information Translations Return to top French (français) Crutch Walking Marche avec béquilles - français (French) ...

  18. Thyroid Diseases - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Arabic (???????) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Japanese (???) Korean (???) Russian (???????) Somali ( ... Bilingual PDF Health Information Translations Return to top French (français) Thyroid Biopsy Biopsie thyroïdienne - français (French) Bilingual ...

  19. Bladder Diseases - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Arabic (???????) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) ... Bilingual PDF Health Information Translations Return to top French (français) Care of a Foley Catheter Entretien d' ...

  20. Cancer Chemotherapy - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Bosnian (Bosanski) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) ... Bilingual PDF Health Information Translations Return to top French (français) Chemotherapy Chimiothérapie - français (French) Bilingual PDF Health ...

  1. Prenatal Care - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Bosnian (Bosanski) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) ... Bilingual PDF Health Information Translations Return to top French (français) Fetal Movement Count Compte des mouvements du ...

  2. Vascular Diseases - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Bosnian (Bosanski) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) ... Bilingual PDF Health Information Translations Return to top French (français) Angiogram Angiogramme - français (French) Bilingual PDF Health ...

  3. Gallbladder Diseases - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Arabic (???????) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) ... Bilingual PDF Health Information Translations Return to top French (français) ERCP (Endoscopic Retrograde Cholangiopancreatography) CPRE (Cholangio-pancréatographie ...

  4. Kidney Diseases - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Multiple Languages Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) ... ???? (Chinese - Traditional) Bilingual PDF Health Information Translations French (français) 24-Hour Urine Test Test d'urine ...

  5. Radiation Therapy - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Bosnian (Bosanski) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) ... Bilingual PDF Health Information Translations Return to top French (français) Preventing Infections When Your White Blood Cell ...

  6. Anal Disorders - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... enable JavaScript. Anal Disorders - Multiple Languages Arabic (???????) French (français) Hindi (??????) Japanese (???) Korean (???) ... ???????? ??? ?????? - ??????? Bilingual Health Information Translations French (français) Barium Enema Lavement baryté - français (French) Bilingual ...

  7. Colorectal Cancer - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Bosnian (Bosanski) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) ... Bilingual PDF Health Information Translations Return to top French (français) Cancer of the Colon and Rectum Cancer ...

  8. Heart Diseases - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Bosnian (Bosanski) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) ... Bilingual PDF Health Information Translations Return to top French (français) Angiogram Angiogramme - français (French) Bilingual PDF Health ...

  9. Appendicitis - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Arabic (???????) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) ... Bilingual PDF Health Information Translations Return to top French (français) Appendectomy Appendicectomie - français (French) Bilingual PDF Health ...

  10. Surgery - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Bosnian (Bosanski) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) ... Bilingual PDF Health Information Translations Return to top French (français) Biopsy Biopsie - français (French) Bilingual PDF Health ...

  11. Childbirth - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Bosnian (Bosanski) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) ... Bilingual PDF Health Information Translations Return to top French (français) Epidural Pain Relief for Labor and Delivery ...

  12. Radiation Emergencies - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Arabic (???????) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) ... Bilingual PDF Health Information Translations Return to top French (français) Decontamination Décontamination - français (French) Bilingual PDF Health ...

  13. Patient Safety - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Bosnian (Bosanski) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) ... Bilingual PDF Health Information Translations Return to top French (français) Appointment Reminder Fiche de rendez-vous - français ( ...

  14. Sleep Apnea - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Arabic (???????) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) ... Chinese Community Health Resource Center Return to top French (français) Common Sleep Problem Problèmes de sommeil courants - ...

  15. Pregnancy - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Bosnian (Bosanski) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) ... Bilingual PDF Health Information Translations Return to top French (français) A Healthy Pregnancy Une grossesse saine - français ( ...

  16. Cancer - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Bosnian (Bosanski) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Khmer (Khmer) ... Chinese Community Health Resource Center Return to top French (français) Biopsy Biopsie - français (French) Bilingual PDF Health ...

  17. Alzheimer's Disease - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Bosnian (Bosanski) Chinese - Simplified (????) Chinese - Traditional (????) French (français) German (Deutsch) Hindi (??????) Italian (italiano) ... ???? (Chinese - Traditional) Alzheimer's Association Return to top French (français) Alzheimer's Disease Maladie d'Alzheimer - français (French) ...

  18. Vaginal Diseases - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Arabic (???????) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) ... Bilingual PDF Health Information Translations Return to top French (français) Colposcopy Colposcopie - français (French) Bilingual PDF Health ...

  19. Colonoscopy - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Arabic (???????) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) ... Bilingual PDF Health Information Translations Return to top French (français) Colonoscopy with Bowel Prep: Go-Lytely, Colyte, ...

  20. Cervical Cancer - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Arabic (???????) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Khmer (Khmer) ... Bilingual PDF Harborview Medical Center Return to top French (français) Colposcopy Colposcopie - français (French) Bilingual PDF Health ...

  1. Swallowing Disorders - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Multiple Languages Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) ... ???? (Chinese - Traditional) Bilingual PDF Health Information Translations French (français) Barium Swallow Déglutition barytée - français (French) Bilingual ...

  2. Breast Cancer - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Bosnian (Bosanski) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Khmer (Khmer) ... Traditional) PDF American Cancer Society Return to top French (français) Breast Biopsy Biopsie mammaire - français (French) Bilingual ...

  3. Acute Bronchitis - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Arabic (???????) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) ... Bilingual PDF Health Information Translations Return to top French (français) Bronchitis Bronchite - français (French) Bilingual PDF Health ...

  4. Sleep Disorders - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Arabic (???????) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) ... Bilingual PDF Health Information Translations Return to top French (français) Common Sleep Problem Problèmes de sommeil courants - ...

  5. Fractures - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Fractures - Multiple Languages Arabic (???????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) ... Institute of Arthritis and Musculoskeletal and Skin Diseases French (français) Bone Fractures Fractures osseuses - français (French) Bilingual ...

  6. Laboratory Tests - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Arabic (???????) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Khmer (Khmer) ... Chinese Community Health Resource Center Return to top French (français) 24-Hour Urine Test Test d'urine ...

  7. Back Injuries - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Multiple Languages Chinese - Simplified (????) Chinese - Traditional (????) French (français) Japanese (???) Korean (???) Russian (???????) Somali ( ... ???? (Chinese - Traditional) Bilingual PDF Health Information Translations French (français) Back Health and Safety Santé et sécurité ...

  8. Asthma - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Bosnian (Bosanski) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) ... Bilingual PDF Health Information Translations Return to top French (français) Asthma Asthme - français (French) Bilingual PDF Health ...

  9. Nuclear Scans - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Arabic (???????) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) ... Bilingual PDF Health Information Translations Return to top French (français) Bone Scan Scintigraphie osseuse - français (French) Bilingual ...

  10. Hypoglycemia - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Arabic (???????) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) ... Chinese Community Health Resource Center Return to top French (français) Fasting Blood Sugar Test Test de glycémie ...

  11. Breastfeeding - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Bosnian (Bosanski) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Hmong (Hmoob) Japanese (???) ... Bilingual PDF Health Information Translations Return to top French (français) Breastfeeding Basics Principes fondamentaux de l'allaitement - ...

  12. Ultrasound - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Arabic (???????) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) ... Bilingual PDF Health Information Translations Return to top French (français) Echocardiogram Échocardiogramme - français (French) Bilingual PDF Health ...

  13. Healthlines | NIH MedlinePlus the Magazine

    MedlinePLUS

    ... at reading and writing. Treating Young People with Type 2 Diabetes The obesity epidemic is causing more children to develop type 2 diabetes. Because type 2 diabetes has primarily been an adult illness until ...

  14. HPV - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... JavaScript. HPV - Multiple Languages Amharic (amarunya) Armenian (???????) Farsi (?????) Hmong (Hmoob) Khmer (Khmer) Oromo (Afaan Oromo) ... Action Coalition; Centers for Disease Control and Prevention Farsi (?????) Human Papillomavirus HPV Vaccine Cervarix English (Farsi) ...

  15. Health Information in Farsi (?????): MedlinePlus

    MedlinePLUS

    ... this page, please enable JavaScript. Health Information in Farsi (?????) C Childhood Immunization Haemophilus Influenzae Type b (Hib) Vaccine - English (Farsi) ????? PDF Immunization Action Coalition; Centers for Disease ...

  16. Hepatitis A - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Burmese (myanmasa) Chinese - Simplified (????) Chinese - Traditional (????) Farsi (?????) Hmong (Hmoob) Khmer (Khmer) Russian (???????) Somali ( ... for Disease Control and Prevention Return to top Farsi (?????) Hepatitis A Vaccine English (Farsi) ????? PDF ...

  17. MedlinePlus FAQ: Search Cloud

    MedlinePLUS

    ... Cool Tools ESPAÑOL Question: How does the search cloud work? To use the sharing features on this page, please enable JavaScript. Answer: The search cloud displays the top 100 search terms typed into ...

  18. Foodborne Illness - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... sharing features on this page, please enable JavaScript. Foodborne Illness - Multiple Languages Chinese - Simplified (????) Chinese - Traditional (????) Spanish (español) Chinese - Simplified (????) Foodborne Illness English ?????? - ???? (Chinese - Simplified) PDF Chinese Community ...

  19. Pesticides - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Bilingual PDF Health Information Translations Return to top French (français) AFP (Alpha-Fetoprotein) Test Test AFP (alpha-foetoprotéine) - français (French) Bilingual PDF Health Information Translations Amniocentesis Amniocentèse - français ( ...

  20. Health Information in Korean (???): MedlinePlus

    MedlinePLUS

    ... ??? (Korean) Bilingual PDF Health Information Translations GTT (Glucose Tolerance Test) GTT (???(???) ??) - ??? (Korean) Bilingual PDF Health Information Translations Diabetes and Pregnancy Diabetes during Pregnancy ?? ? ??? - ...

  1. Health Information in Japanese (???): MedlinePlus

    MedlinePLUS

    ... ??? (Japanese) Bilingual PDF Health Information Translations GTT (Glucose Tolerance Test) GTT (????????) - ??? (Japanese) Bilingual PDF Health Information Translations Two Reasons I Find Time to Prevent Diabetes: My Future and Theirs ??? (Japanese) PDF National ...

  2. Health Information in Ukrainian (??????????): MedlinePlus

    MedlinePLUS

    ... ?????????? (Ukrainian) Bilingual PDF Health Information Translations GTT (Glucose Tolerance Test) GTT (????? ?? ????????????? ?? ???????) - ?????????? (Ukrainian) Bilingual PDF Health Information Translations Diabetes and Pregnancy Diabetes during Pregnancy ?????? ??? ??? ...

  3. Diabetes - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ??? (Japanese) Bilingual PDF Health Information Translations GTT (Glucose Tolerance Test) GTT (????????) - ??? (Japanese) Bilingual PDF Health Information Translations Two Reasons I Find Time to Prevent Diabetes: My Future and Theirs ??? (Japanese) PDF National ...

  4. Title | NIH MedlinePlus the Magazine

    MedlinePLUS

    ... please turn JavaScript on. Medical Movies on the Web Debuts with Gene Kelly's "Combat Fatique Irritability" 1945 ... of Medicine To view Medical Movies on the Web, go to: www.nlm.nih.gov/hmd/collections/ ...

  5. Healthlines | NIH MedlinePlus the Magazine

    MedlinePLUS

    ... dyes and computer programs used to better see biology. Life: Magnified is on display at Washington Dulles ... General Medical Sciences, the American Society for Cell Biology, and the Metropolitan Washington Airports Authority Arts Program. ...

  6. Healthlines | NIH MedlinePlus the Magazine

    MedlinePLUS

    ... Eyes on the Road: The Dangers of Distracted Driving Drivers are doing something else—like eating or texting—about 10 percent of the time they're ... cell phone; almost four times more likely when texting; and three times more ... with an increased risk. "Anything that takes a driver's eyes off the ...

  7. Knee Replacement - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Hindi (??????) Japanese (???) Korean (???) Portuguese (português) Russian (???????) Somali (af Soomaali) Spanish (español) Tagalog ( ... PDF Health Information Translations Return to top Portuguese (português) Total Knee Replacement Substituição total do joelho - português ( ...

  8. Mammography - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Japanese (???) Korean (???) Oromo (Afaan Oromo) Portuguese (português) Russian (???????) Somali (af Soomaali) Spanish (español) Tagalog ( ... PDF Harborview Medical Center Return to top Portuguese (português) Mammogram Mamografia - português (Portuguese) Bilingual PDF Health Information ...

  9. Common Cold - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ????) French (français) Hmong (Hmoob) Khmer (Khmer) Portuguese (português) Spanish (español) Tagalog (Tagalog) Vietnamese (Tiê?ng Viê?t) Chinese - ... Disease Control and Prevention Return to top Portuguese (português) Cover Your Cough English Cubrase quando tossir - português ( ...

  10. Glaucoma - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Hindi (??????) Japanese (???) Korean (???) Portuguese (português) Russian (???????) Somali (af Soomaali) Spanish (español) Vietnamese ( ... PDF Health Information Translations Return to top Portuguese (português) Glaucoma Glaucoma - português (Portuguese) Bilingual PDF Health Information ...

  11. Gallstones - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Hindi (??????) Japanese (???) Korean (???) Portuguese (português) Russian (???????) Somali (af Soomaali) Spanish (español) Vietnamese ( ... PDF Health Information Translations Return to top Portuguese (português) Gall Bladder Removal Surgery Cirurgia para remoção da ...

  12. Depression - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Hindi (??????) Japanese (???) Korean (???) Portuguese (português) Russian (???????) Somali (af Soomaali) Spanish (español) Tagalog ( ... PDF Health Information Translations Return to top Portuguese (português) Feeling Sad Sensação de tristeza - português (Portuguese) Bilingual ...

  13. Hysterectomy - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Hindi (??????) Japanese (???) Korean (???) Portuguese (português) Russian (???????) Somali (af Soomaali) Spanish (español) Vietnamese ( ... PDF Health Information Translations Return to top Portuguese (português) Hysterectomy Histerectomia - português (Portuguese) Bilingual PDF Health Information ...

  14. Menopause - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Hindi (??????) Japanese (???) Korean (???) Portuguese (português) Russian (???????) Somali (af Soomaali) Spanish (español) Vietnamese ( ... PDF Health Information Translations Return to top Portuguese (português) Managing Menopause Controle da menopausa - português (Portuguese) Bilingual ...

  15. After Surgery - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Surgery Instructions relatives aux soins à domicile après une intervention chirurgicale - français (French) Bilingual PDF Health Information ... Hospital Care After Surgery Vos soins hospitaliers après une intervention chirurgicale - français (French) Bilingual PDF Health Information ...

  16. Rehabilitation - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... sharing features on this page, please enable JavaScript. Rehabilitation - Multiple Languages Arabic (???????) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) ...

  17. Tutorials for Africa - Diarrhea: MedlinePlus

    MedlinePLUS

    Tutorials for Africa: Diarrhea Diarrhea remains one of the leading causes of childhood morbidity and mortality in the developing world. This ... Playing Tutorial) View a printer-friendly summary: Japadhola (PDF Summary) Luganda (PDF Summary) Luo (PDF Summary) Runyankole ( ...

  18. Welcome to MedlinePlus en español

    MedlinePLUS

    ... and easily?" Don Francisco asks Hispanic TV and radio audiences in public service announcements released in May. ... The new public service campaign, including television and radio announcements featuring Don Francisco, will target U.S. Hispanic ...

  19. Hepatitis - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ?????? ????? ???????? - ??????? Bilingual PDF Health Information Translations Chinese - Simplified (????) Viral Hepatitis ????? - ???? (Chinese - Simplified) Bilingual PDF Health Information Translations Chinese - Traditional (????) Viral Hepatitis ????? - ???? (Chinese - ...

  20. CT Scans - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ?????? ???????? ????????? - ??????? Bilingual PDF Health Information Translations CT Scan English (Arabic) ??????? ?????? ??????? - ??????? ... ?? - ???? (Chinese - Simplified) Bilingual PDF Health Information Translations Chinese - Traditional (????) CT (Computerized Tomography) Scan CT ( ...

  1. Headache - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ???????) Headaches (Arabic) ??????? Bilingual PDF Health Information Translations Chinese - Simplified (????) Headaches ?? - ???? (Chinese - Simplified) Bilingual PDF Health Information Translations Chinese - Traditional (????) Headaches ?? - ???? (Chinese - Traditional) ...

  2. Diabetic Foot - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... sharing features on this page, please enable JavaScript. Diabetic Foot - Multiple Languages Amharic (amarunya) Arabic (???????) Chinese - Simplified ( ... ??????? Multimedia Patient Education Institute Chinese - Simplified (????) Diabetic Foot Care English ??????? - ???? (Chinese - Simplified) PDF Chinese ...

  3. Videos and Cool Tools: MedlinePlus

    MedlinePLUS

    ... Test your knowledge with the interactive tutorials and games. Check your health by using the calculators and ... latest news Anatomy Videos Surgery Videos Calculators & Quizzes Games All calculators & quizzes Antibiotics Quiz Asthma Quiz Breast ...

  4. Streptococcal Infections - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Strep Throat (Arabic) ??????? Bilingual PDF Health Information Translations Korean (???) Strep Throat ??? ??? - ??? (Korean) Bilingual PDF Health Information Translations Spanish (español) Infecciones por estreptococo Return to top ...

  5. Dementia - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Person with Dementia in Planning for the Future English ?? ?? - ??? (Korean) PDF Alzheimer's Association Types of Dementia ????? - ??? (Korean) Bilingual PDF Health Information Translations Return to top Russian (???????) Types of Dementia ...

  6. Hemorrhoids - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... sharing features on this page, please enable JavaScript. Hemorrhoids - Multiple Languages Arabic (???????) Chinese - Simplified (????) Chinese - Traditional (????) Spanish (español) Arabic (???????) Hemorrhoid Surgery English (Arabic) ????? ???????? - ??????? Multimedia Patient ...

  7. Back Pain - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ???????) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Japanese (???) Korean (???) Russian (???????) Somali (af ... Musculoskeletal and Skin Diseases Return to top French (français) Exercises for Your Back Exercices pour votre dos - ...

  8. Arthritis - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Multiple Languages Arabic (???????) Chinese - Simplified (????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian ( ... Chinese - Simplified) Bilingual PDF Health Information Translations French (français) Arthritis Arthrite - français (French) Bilingual PDF Health Information ...

  9. Brain Diseases - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... please enable JavaScript. Brain Diseases - Multiple Languages French (français) Japanese (???) Korean (???) Russian (???????) Somali (af Soomaali) Spanish (español) Ukrainian (??????????) French (français) Brain Scan Scintigraphie cérébrale - français (French) Bilingual PDF ...

  10. Bone Cancer - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ???????) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian ( ... PDF Health Information Translations Return to top French (français) Bone Scan Scintigraphie osseuse - français (French) Bilingual PDF ...

  11. Angioplasty - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Bosanski) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian ( ... PDF Health Information Translations Return to top French (français) Heart Cath and Heart Angioplasty Cathétérisme cardiaque et ...

  12. Atrial Fibrillation - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Bosanski) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) Portuguese ( ... PDF Health Information Translations Return to top French (français) Atrial Fibrillation Fibrillation auriculaire - français (French) Bilingual PDF ...

  13. Concussion - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... enable JavaScript. Concussion - Multiple Languages Arabic (???????) French (français) Japanese (???) Korean (???) Russian (???????) Somali (af ... ?????? ?????? - ??????? Multimedia Patient Education Institute French (français) Types of Brain Injury Types de lésions cérébrales - ...

  14. Cataract - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ???????) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) Portuguese ( ... Community Health Resource Center Return to top French (français) Cataract Cataracte - français (French) Bilingual PDF Health Information ...

  15. Colonic Diseases - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... JavaScript. Colonic Diseases - Multiple Languages Arabic (???????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian ( ... ??? ?????? - ??????? Bilingual Health Information Translations French (français) Barium Enema Lavement baryté - français (French) Bilingual PDF ...

  16. Chronic Bronchitis - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ???????) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian ( ... Community Health Resource Center Return to top French (français) Bronchitis Bronchite - français (French) Bilingual PDF Health Information ...

  17. Animal Bites - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ???????) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) Portuguese ( ... PDF Health Information Translations Return to top French (français) Animal Bites and Scratches Morsures et griffures d' ...

  18. Burns - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ???????) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian ( ... PDF Health Information Translations Return to top French (français) Burn Care Soins des brûlures - français (French) Bilingual ...

  19. Breast Diseases - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ???????) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian ( ... PDF Health Information Translations Return to top French (français) Breast Biopsy Biopsie mammaire - français (French) Bilingual PDF ...

  20. Breathing Problems - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... please enable JavaScript. Breathing Problems - Multiple Languages French (français) Hindi (??????) Japanese (???) Korean (???) Russian ( ... Somali (af Soomaali) Spanish (español) Ukrainian (??????????) French (français) Incentive Spirometer Spiromètre incitatif - français (French) Bilingual PDF ...

  1. Bone Diseases - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Languages Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian ( ... Chinese - Traditional) Bilingual PDF Health Information Translations French (français) Bone Scan Scintigraphie osseuse - français (French) Bilingual PDF ...

  2. Healthlines | NIH MedlinePlus the Magazine

    MedlinePLUS

    ... Institute on Aging and the National Library of Medicine. Taking a Genomic Journey A new exhibition gives people a unique look at the genome—all the hereditary material of an organism. "Genome: ...

  3. Stomach Disorders - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... sharing features on this page, please enable JavaScript. Stomach Disorders - Multiple Languages Arabic (???????) Chinese - Simplified (????) Chinese - ... Chinese - Simplified (????) Principles of Nutritional Care for Gastritis and/or Ulcer English ???????? - ???? (Chinese - Simplified) ...

  4. Thalassemia - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... sharing features on this page, please enable JavaScript. Thalassemia - Multiple Languages Chinese - Simplified (????) Chinese - Traditional (????) Spanish (español) Chinese - Simplified (????) Thalassemia English ??????? - ???? (Chinese - Simplified) PDF Chinese Community ...

  5. Dietary Fats - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... sharing features on this page, please enable JavaScript. Dietary Fats - Multiple Languages Chinese - Simplified (????) Chinese - Traditional (????) Spanish (español) Chinese - Simplified (????) Are All Dietary Fats the Same? English ???????? - ???? (Chinese - Simplified) PDF ...

  6. Plague - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... sharing features on this page, please enable JavaScript. Plague - Multiple Languages Amharic (amarunya) Hmong (Hmoob) Spanish (español) Amharic (amarunya) Plague English amarunya (Amharic) PDF Minnesota Department of Health ...

  7. Cholesterol - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Japanese (???) Korean (???) Portuguese (português) Russian (???????) Somali (af Soomaali) Spanish (español) Tagalog (Tagalog) Ukrainian (??????????) ... Bilingual PDF Health Information Translations Return to top Somali (af Soomaali) Cholesterol Baruur (Cholesterol) - af Soomaali (Somali) ...

  8. Dialysis - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... JavaScript. Dialysis - Multiple Languages Arabic (???????) Russian (???????) Somali (af Soomaali) Spanish (español) Arabic (???????) Dialysis (Arabic) ... ?????? - ??????? (Russian) Bilingual PDF Health Information Translations Somali (af Soomaali) Dialysis Kaadi-saarista - af Soomaali (Somali) ...

  9. MedlinePlus XML Data Sources

    MedlinePLUS

    ... topic title, URL, language, date created, and ID), • vocabulary (MeSH, “Also called” terms, see references), • full summary, • group membership, • related health topics, • equivalent English or Spanish topics, • related content in other languages, • ...

  10. Healthlines | NIH MedlinePlus the Magazine

    MedlinePLUS

    ... report promising results in prevention and treatment of Ebola virus disease (from left) NIH Director Dr. Francis ... Gallin exit the Clinical Center with recently discharged Ebola patient Nina Pham (next to Dr. Fauci). NIH's ...

  11. Healthlines | NIH MedlinePlus the Magazine

    MedlinePLUS

    ... Healthlines Past Issues / Fall 2014 Table of Contents Ebola Virus Disease Information The outbreak of Ebola virus disease in West Africa may have you looking for accurate and updated information. The Ebola topic page on Medlineplus.gov rounds up helpful ...

  12. Healthline | NIH MedlinePlus the Magazine

    MedlinePLUS

    ... You Need to Know About Prescription and Illicit Drug Abuse A new health topic page on NIHSeniorHealth.gov ... to watch for and what to do about drug abuse among older Americans. National surveys find more Baby ...

  13. Healthlines | NIH MedlinePlus the Magazine

    MedlinePLUS

    ... health professionals would see with the naked eye. Drug Abuse Information Goes Mobile It's now easier for teenagers ... who care for them to get answers about drug abuse and addiction. NIH's National Institute on Drug Abuse ( ...

  14. Oncofertility | NIH MedlinePlus the Magazine

    MedlinePLUS

    ... ending. After one IUI attempt, I became pregnant with Lincoln. A small part of me feels silly even writing this because now I know so many people who have struggled to have children. People who try for years, who cannot identify ... after procedure with no results. It is with this perspective that ...

  15. Hazardous Waste - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... features on this page, please enable JavaScript. Hazardous Waste - Multiple Languages Chinese - Simplified (????) Spanish (español) Chinese - Simplified (????) Protect Yourself, Protect Others: Safe Options for Home Needle Disposal English ?????????????????? - ???? (Chinese - Simplified) PDF ...

  16. Medication Errors - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... sharing features on this page, please enable JavaScript. Medication Errors - Multiple Languages Chinese - Simplified (????) Chinese - Traditional (????) Spanish (español) Chinese - Simplified (????) Proper Use of Medications English ?????????? - ???? (Chinese - Simplified) PDF Chinese Community ...

  17. Earthquakes - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... sharing features on this page, please enable JavaScript. Earthquakes - Multiple Languages Haitian Creole (Kreyol) Spanish (español) Haitian ... Kreyol) Parent Guidelines for Helping Children After an Earthquake English Konsèy pou paran ka ede timoun yo ...

  18. Arrhythmia - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ?????? ??? ????? - ??????? Multimedia Patient Education Institute Electrocardiogram (ECG or EKG) (Arabic) ??????? Bilingual PDF Health Information Translations EPS (Electrophysiology Study) (Arabic) ??????? Bilingual PDF Health Information Translations Chinese - ...

  19. Health Information in Hindi (??????): MedlinePlus

    MedlinePLUS

    ... ???? (Hindi) Bilingual PDF Health Information Translations Arrhythmia Electrocardiogram (ECG or EKG) ?????? (Hindi) Bilingual PDF Health Information Translations EPS (Electrophysiology Study) ?????? (Hindi) Bilingual PDF Health Information Translations ...

  20. Health Information in Arabic (???????): MedlinePlus

    MedlinePLUS

    ... ?????? ??? ????? - ??????? Multimedia Patient Education Institute Electrocardiogram (ECG or EKG) (Arabic) ??????? Bilingual PDF Health Information Translations EPS (Electrophysiology Study) (Arabic) ??????? Bilingual PDF Health Information Translations Arthritis ...

  1. Childhood Immunization - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Burmese (myanmasa) Chinese - Simplified (????) Chinese - Traditional (????) Croatian (Hrvatski) Farsi (?????) French (français) German (Deutsch) Haitian ... Bilingual PDF Health Information Translations Return to top Croatian (Hrvatski) Haemophilus Influenzae Type b (Hib) Vaccine English ...

  2. Health Information in Russian (???????): MedlinePlus

    MedlinePLUS

    ... PDF Health Information Translations HPV Human Papillomavirus HPV (Gardasil) VIS - English ??????? ?????? ??? (?????? ????????? ????????) - Gardasil - ??????? (Russian) PDF Immunization Action Coalition; Centers for ...

  3. MedlinePlus Connect in Use

    MedlinePLUS

    ... Cara EHR ChiroPad EMR ChiroSuite EHR CentriHealth's Individual Health Record (IHR) ClinicTracker ClinicTree ComChart EMR Dexter Solutions eZDocs drchrono EHR DrFirst Patient Advisor DrFirst RcopiaMD ...

  4. Effect of rapid HIV testing on HIV incidence and services in populations at high risk for HIV exposure: an equity-focused systematic review

    PubMed Central

    Pottie, Kevin; Medu, Olanrewaju; Welch, Vivian; Dahal, Govinda P; Tyndall, Mark; Rader, Tamara; Wells, George

    2014-01-01

    Objective To assess the effects of rapid voluntary counselling and testing (VCT) for HIV on HIV incidence and uptake of HIV/AIDS services in people at high risk for HIV exposure. Design Cochrane systematic review and meta-analysis. Data sources We searched PubMed, EMBASE, AIDSearch, LILACS, Global Health, Medline Africa, PsychInfo, CINAHL, Cochrane CENTRAL, Cochrane HIV/AIDS Group Specialized Register and grey literature from 1 January 2001 to 5 June 2014 without language restriction. Data selection We included controlled studies that compared rapid VCT with conventional testing among people at risk for HIV exposure. Data extraction Two reviewers extracted data. We used Cochrane risk of bias tool and GRADE criteria: risk of bias, inconsistency, indirectness, imprecision and publication bias. For observational studies we used the Newcastle-Ottawa Scale. We used the PRISMA-Equity reporting guideline. Results From 2441 articles, we included 8 randomised controlled trials and 5 observational studies. Rapid VCT was associated with a threefold increase in HIV-testing uptake (relative risk (RR)=2.95 95% CI 1.69 to 5.16) and a twofold increase in the receipt of test results (RR=2.14, 95% CI 1.08 to 4.24). Women accepted testing more often than men in rapid VCT arm, but no differences in effect for age or socioeconomic status. Observational studies also showed rapid VCT led to higher rates of uptake of testing. Heterogeneity was high. A cluster-randomised trial reported an 11% reduction in HIV incidence in intervention communities (RR=0.89, 95% CI=0.63 to 1.24) over 3?years trial. Conclusions Rapid VCT in health facilities and communities was associated with a large increase in HIV-testing uptake and receipt of results. This has implications for WHO guidelines. The routine use of rapid VCT may also help avoid human rights violations among marginalised populations where testing may occur without informed consent and where existing stigma may create barriers to testing. PMID:25510889

  5. Herbal Medications Commonly Used in the Practice of Rheumatology: Mechanisms of Action, Efficacy, and Side Effects

    Microsoft Academic Search

    Arathi R. Setty; Leonard H. Sigal

    2005-01-01

    OBJECTIVE To review the literature on herbal preparations commonly utilized in the treatment of rheumatic indications. METHODS Search of MEDLINE (PubMed) was performed using both the scientific and the common names of herbs. Relevant articles in English were collected from PubMed and reviewed. RESULTS This review summarizes the efficacy and toxicities of herbal remedies used in complementary and alternative medical

  6. UNIVERSIDADE FEDERAL DO PARAN -SETOR DE CINCIAS DA SADE SIBI -BIBLIOTECA DE CINCIAS DA SADE -SD

    E-print Network

    Paraná, Universidade Federal do

    ? Nephrology, dialysis, transplantation plus, v.3, p.89- 90, 2010. 2010 PubMed Artigo Mauricio de Carvalho et Medline Artigo Mauricio de Carvalho et al. Resistência à proteína C ativada e doença arterial isquêmica em jovem. Arquivos Brasileiros de Cardiologia, v.94, p.e31-e33, 2010. 2010 Lilacs Medline Artigo Mauricio

  7. cole Doctorale Information Communication Modlisation et Simulation (ED ICMS Thse de doctorat

    E-print Network

    Paris-Sud XI, Université de

    une indexation qualitative en utilisant un filtrage personnalisé. L'index n'est plus d Medline via PubMed constitue une démonstration de la complexité d'expression d'une problématique de de mettre en avant des documents contenus dans Medline qui ne répondent pas ou peu à une indexation

  8. UNIVERSIDADE FEDERAL DO PARAN -SETOR DE CINCIAS DA SADE SIBI -BIBLIOTECA DE CINCIAS DA SADE -SD

    E-print Network

    Paraná, Universidade Federal do

    --is there a link? NDT Plus, p.1-2, 2009. 2009 PubMed Artigo José Gastão Rocha de Carvalho et al. Reserva renal em Medline Artigo José Gastão Rocha de Carvalho et al. Alterações ponderais no pós-transplante renal. Revista, 2006. 2006 Lilacs Medline Artigo #12;José Gastão Rocha de Carvalho et al. Insuficiência renal aguda

  9. Systematic Review and Meta-Analysis of Vancomycin-Induced Nephrotoxicity Associated with Dosing Schedules That Maintain Troughs between 15 and 20 Milligrams per Liter

    PubMed Central

    Paterson, D. L.; Lodise, T. P.

    2013-01-01

    In an effort to maximize outcomes, recent expert guidelines recommend more-intensive vancomycin dosing schedules to maintain vancomycin troughs between 15 and 20 mg/liter. The widespread use of these more-intensive regimens has been associated with an increase in vancomycin-induced nephrotoxicity reports. The purpose of this systematic literature review is to determine the nephrotoxicity potential of maintaining higher troughs in clinical practice. All studies pertaining to vancomycin-induced nephrotoxicity between 1996 and April 2012 were identified from PubMed, Embase, Cochrane Controlled Trial Registry, and Medline databases and analyzed according to Cochrane guidelines. Of the initial 240 studies identified, 38 were reviewed, and 15 studies met the inclusion criteria. Overall, higher troughs (?15 mg/liter) were associated with increased odds of nephrotoxicity (odds ratio [OR], 2.67; 95% confidence interval [CI], 1.95 to 3.65) relative to lower troughs of <15 mg/liter. The relationship between a trough of ?15 mg/liter and nephrotoxicity persisted when the analysis was restricted to studies that examined only initial trough concentrations (OR, 3.12; 95% CI, 1.81 to 5.37). The relationship between troughs of ?15 mg/liter and nephrotoxicity persisted after adjustment for covariates known to independently increase the risk of a nephrotoxicity event. An incremental increase in nephrotoxicity was also observed with longer durations of vancomycin administration. Vancomycin-induced nephrotoxicity was reversible in the majority of cases, with short-term dialysis required only in 3% of nephrotoxic episodes. The collective literature indicates that an exposure-nephrotoxicity relationship for vancomycin exists. The probability of a nephrotoxic event increased as a function of the trough concentration and duration of therapy. PMID:23165462

  10. Systematic review and meta-analysis of vancomycin-induced nephrotoxicity associated with dosing schedules that maintain troughs between 15 and 20 milligrams per liter.

    PubMed

    van Hal, S J; Paterson, D L; Lodise, T P

    2013-02-01

    In an effort to maximize outcomes, recent expert guidelines recommend more-intensive vancomycin dosing schedules to maintain vancomycin troughs between 15 and 20 mg/liter. The widespread use of these more-intensive regimens has been associated with an increase in vancomycin-induced nephrotoxicity reports. The purpose of this systematic literature review is to determine the nephrotoxicity potential of maintaining higher troughs in clinical practice. All studies pertaining to vancomycin-induced nephrotoxicity between 1996 and April 2012 were identified from PubMed, Embase, Cochrane Controlled Trial Registry, and Medline databases and analyzed according to Cochrane guidelines. Of the initial 240 studies identified, 38 were reviewed, and 15 studies met the inclusion criteria. Overall, higher troughs (? 15 mg/liter) were associated with increased odds of nephrotoxicity (odds ratio [OR], 2.67; 95% confidence interval [CI], 1.95 to 3.65) relative to lower troughs of <15 mg/liter. The relationship between a trough of ? 15 mg/liter and nephrotoxicity persisted when the analysis was restricted to studies that examined only initial trough concentrations (OR, 3.12; 95% CI, 1.81 to 5.37). The relationship between troughs of ? 15 mg/liter and nephrotoxicity persisted after adjustment for covariates known to independently increase the risk of a nephrotoxicity event. An incremental increase in nephrotoxicity was also observed with longer durations of vancomycin administration. Vancomycin-induced nephrotoxicity was reversible in the majority of cases, with short-term dialysis required only in 3% of nephrotoxic episodes. The collective literature indicates that an exposure-nephrotoxicity relationship for vancomycin exists. The probability of a nephrotoxic event increased as a function of the trough concentration and duration of therapy. PMID:23165462

  11. Radiofrequency ablation for chronic low back pain: A systematic review of randomized controlled trials

    PubMed Central

    Leggett, Laura E; Soril, Lesley JJ; Lorenzetti, Diane L; Noseworthy, Tom; Steadman, Rodney; Tiwana, Simrandeep; Clement, Fiona

    2014-01-01

    BACKGROUND: Radiofrequency ablation (RFA), a procedure using heat to interrupt pain signals in spinal nerves, is an emerging treatment option for chronic low back pain. Its clinical efficacy has not yet been established. OBJECTIVE: To determine the efficacy of RFA for chronic low back pain associated with lumbar facet joints, sacroiliac joints, discogenic low back pain and the coccyx. METHODS: A systematic review was conducted. Medline, EMBASE, PubMed, SPORTDiscus, CINAHL and the Cochrane Library were searched up to August 2013. Abstracts and full-text articles were reviewed in duplicate. Included articles were sham-controlled randomized controlled trials (RCTs), assessed the efficacy of RFA, reported at least one month of follow-up and included participants who had experienced back pain for at least three months. Data were extracted in duplicate and quality was assessed using the Cochrane Risk of Bias tool. Due to heterogeneity, as well as a lack of reported mean differences and SDs, meta-analysis was not possible using these data. RESULTS: The present systematic review retrieved 1063 abstracts. Eleven sham-controlled RCTs were included: three studies involving discogenic back pain; six studies involving lumbar facet joint pain; and two studies involving sacroiliac joint pain. No studies were identified assessing the coccyx. The evidence supports RFA as an efficacious treatment for lumbar facet joint and sacroiliac joint pain, with five of six and both of the RCTs demonstrating statistically significant pain reductions, respectively. The evidence supporting RFA for the treatment of discogenic pain is mixed. CONCLUSIONS: While the majority of the studies focusing on lumbar facet joints and sacroiliac joints suggest that RFA significantly reduces pain in short-term follow-up, the evidence base for discogenic low back pain is mixed. There is no RCT evidence for RFA for the coccyx. Future studies should examine the clinical significance of the achieved pain reduction and the long-term efficacy of RFA. PMID:25068973

  12. Does Vitamin E Improve the Outcomes of Pediatric Nonalcoholic Fatty Liver Disease? A Systematic Review and Meta-analysis

    PubMed Central

    Sarkhy, Ahmed A.; Al-Hussaini, Abdulrahman A.; Nobili, Valerio

    2014-01-01

    Background and Aims: To systemically evaluate the efficacy of adjuvant vitamin E on the outcomes of nonalcoholic fatty liver disease (NAFLD) and/or nonalcoholic steatohepatitis (NASH) in children. Materials and Methods: We searched MEDLINE, PUBMED, EMBASE, the Cochrane Central Register Controlled Trials, and the Cochrane Database of Systematic Reviews over the period between January 1980 and September 2012 for the studies that examined the role of adjuvant vitamin E given at any dose or duration, alone or in combination with other interventions, on the outcome of pediatric NAFLD. The outcomes are alanine aminotransferase (ALT) normalization and histological improvement. Results: Five randomized trials were eligible to be included in our analysis, with a total of 270 participants. There was no statistically significant difference in the effect of adjuvant vitamin E on normalizing serum ALT [risk ratio (RR) =1.18, confidence interval (CI) =0.92-1.53, P = 0.77 for heterogeneity, I2 = 0%]. Sensitivity analysis showed that using higher doses of vitamin E, a longer duration of therapy or adding vitamin C did not change the effect on the measured outcome. Only two studies looked at histological changes as an outcome. We observed substantial heterogeneity between the two studies. Conclusions: Our meta-analysis did not find a significant effect of adjuvant vitamin E over placebo in normalizing serum ALT. Data on the long-term effect of adjuvant vitamin E on histological improvements in NAFLD patients are still lacking. Larger, well-designed randomized controlled trials (RCTs) in children with histological endpoints are still needed to answer this question. PMID:24976277

  13. A Systematic Review of Psychological Interventions for Adult and Pediatric Patients with Vocal Cord Dysfunction

    PubMed Central

    Guglani, Loveleen; Atkinson, Sarah; Hosanagar, Avinash; Guglani, Lokesh

    2014-01-01

    Background: Vocal cord dysfunction (VCD) or paradoxical vocal-fold motion (PVFM) is a functional disorder of the vocal cords that requires multidisciplinary treatment. Besides relaxation techniques, the use of psychological interventions can help treat the underlying psychological co-morbidities. There is currently no literature that examines the effectiveness of psychological interventions for VCD/PVFM. Objectives: To review the evidence for psychological interventions used for the treatment of patients with VCD/PVFM. Data sources: We searched electronic databases for English medical literature using Pubmed (Medline), PsycInfo, Cochrane Database of Systematic Reviews, Cochrane Central Registry of Controlled Trials, and Clinicaltrials.gov. The date range for our search is from June 1964 to June 2014. Study eligibility criteria, participants, and interventions: We included studies that reported the use of psychological interventions in both adults and children diagnosed with VCD/PVFM. We included randomized controlled trials, case-control studies, retrospective chart reviews, prospective case series, and individual case reports. Results: Most reported studies are small case series or individual case reports that have described the use of interventions such as psychotherapy, behavioral therapy, use of anti-anxiety and anti-depressant medications, and hypnotherapy in conjunction with breathing exercises taught by speech therapists for symptomatic relief. Among the various psychological interventions that have been reported, there is no data regarding effectiveness and/or superiority of one approach over another in either adult or pediatric patients. Conclusions: Psychological interventions have a role to play in the management of adult and pediatric patients with VCD/PVFM. Future prospective studies using uniform approaches for treatment of associated psychopathology may help address this question. PMID:25152871

  14. The Effect of Probiotics on Prevention of Common Cold: A Meta-Analysis of Randomized Controlled Trial Studies

    PubMed Central

    Kang, En-Jin; Hwang, In-Hong; Ji, Yun-Jeong

    2013-01-01

    Background Probiotics are currently under focus for their immune improvement function. Many studies have been performed to assess the potential efficacy of probiotics in allergic disease, viral disease, respiratory disease, as well as gastrointestinal disease. This study performed a systematic review to determine the effects of probiotics on the prevention of the common cold. Methods We searched MEDLINE (PubMed), EMBASE, CINAHL, and Cochrane CENTRAL for studies released through June 2011. Two authors independently extracted the data. To assess the risk of bias of included literatures, Cochrane Collaboration's risk of bias tool was used. Results We identified 10 studies in 7 articles. A total 2,894 participants, 1,588 in the probiotics group and 1,306 in the control group, were included. The effect of probiotics on the prevention of the common cold had a relative risk (RR) of 0.92 (95% CI, 0.85 to 1.00, I2 = 26%). In the subgroup analysis, the RR of administration of probiotics for 3 months or less was 0.82 (95% CI, 0.70 to 0.97). The RR of administration of probiotics over 3 months was 1.00 (95% CI, 0.92 to 1.09). The RR of administration of probiotics without any active intervention (vitamin and mineral) was 0.87 (95% CI, 0.78 to 0.97). Conclusion In this meta-analysis, there was marginal effect of probiotics on the prevention of the common cold. The results implied that probiotics had a modest effect in common cold reduction. The balance of benefit and harms needs to be considered when using probiotics for common cold prevention. PMID:23372900

  15. Control Group Design, Contamination and Drop-Out in Exercise Oncology Trials: A Systematic Review

    PubMed Central

    Steins Bisschop, Charlotte N.; Courneya, Kerry S.; Velthuis, Miranda J.; Monninkhof, Evelyn M.; Jones, Lee W.; Friedenreich, Christine; van der Wall, Elsken; Peeters, Petra H. M.; May, Anne M.

    2015-01-01

    Purpose Important considerations for exercise trials in cancer patients are contamination and differential drop-out among the control group members that might jeopardize the internal validity. This systematic review provides an overview of different control groups design characteristics of exercise-oncology trials and explores the association with contamination and drop-out rates. Methods Randomized controlled exercise-oncology trials from two Cochrane reviews were included. Additionally, a computer-aided search using Medline (Pubmed), Embase and CINAHL was conducted after completion date of the Cochrane reviews. Eligible studies were classified according to three control group design characteristics: the exercise instruction given to controls before start of the study (exercise allowed or not); and the intervention the control group was offered during (any (e.g., education sessions or telephone contacts) or none) or after (any (e.g., cross-over or exercise instruction) or none) the intervention period. Contamination (yes or no) and excess drop-out rates (i.e., drop-out rate of the control group minus the drop-out rate exercise group) were described according to the three design characteristics of the control group and according to the combinations of these three characteristics; so we additionally made subgroups based on combinations of type and timing of instructions received. Results 40 exercise-oncology trials were included based on pre-specified eligibility criteria. The lowest contamination (7.1% of studies) and low drop-out rates (excess drop-out rate -4.7±9.2) were found in control groups offered an intervention after the intervention period. When control groups were offered an intervention both during and after the intervention period, contamination (0%) and excess drop-out rates (-10.0±12.8%) were even lower. Conclusions Control groups receiving an intervention during and after the study intervention period have lower contamination and drop-out rates. The present findings can be considered when designing future exercise-oncology trials. PMID:25815479

  16. A Systematic Review of the Effect of Expectancy on Treatment Responses to Acupuncture

    PubMed Central

    Colagiuri, Ben; Smith, Caroline A.

    2012-01-01

    Randomised controlled trials (RCTs) of acupuncture often find equivalent responses to real and placebo acupuncture despite both appearing superior to no treatment. This raises questions regarding the mechanisms of acupuncture, especially the contribution of patient expectancies. We systematically reviewed previous research assessing the relationship between expectancy and treatment responses following acupuncture, whether real or placebo. To be included, studies needed to assess and/or manipulate expectancies about acupuncture and relate these to at least one health-relevant outcome. Nine such independent studies were identified through systematic searches of Medline, PsycInfo, PubMed, and Cochrane Clinical Trials Register. The methodology and reporting of these studies were quite heterogeneous, meaning that meta-analysis was not possible. A descriptive review revealed that five studies found statistically significant effects of expectancy on a least one outcome, with three also finding evidence suggestive of an interaction between expectancy and type of acupuncture (real or placebo). While there were some trends in significant effects in terms of study characteristics, their generality is limited by the heterogeneity of study designs. The differences in design across studies highlight some important methodological considerations for future research in this area, particularly regarding whether to assess or manipulate expectancies and how best to assess expectancies. PMID:22203882

  17. Rate of early onset Alzheimer’s disease: a systematic review and meta-analysis

    PubMed Central

    Zhu, Xi-Chen; Wang, Hui-Fu; Jiang, Teng; Cao, Lei; Wang, Chong; Wang, Jun; Tan, Chen-Chen; Meng, Xiang-Fei

    2015-01-01

    It is generally accepted that the population rate of early onset Alzheimer’s disease (EOAD) in Alzheimer’s disease (AD) is 1-2%. However, the true population based rate of EOAD has never been verified by a systematic review and meta-analysis. We used electronic searches of Cochrane Library, Embase, Medline and PubMed databases to identify published related studies. The systematic review and meta-analysis was then to be conducted to calculate a pooled rate of EOAD and make comparisons between studies and geographic distribution. A total of 13 papers were included in our systematic review and meta-analysis. The rate of EOAD, 5.5% [95% confidence interval (CI): 0.039-0.079, P<0.001], was generated after pooled analysis of all studies in random effect model. The pooled analysis of the rate in developed country was 5.9% (95% CI: 0.040-0.085, P<0.001). The pooled analysis of the rate in developing countries was 4.4% (95% CI: 0.028-0.066, P<0.001). Our study showed that the rate of EOAD in AD is 5.5%, not 1-2% as usually demonstrated. And our results indicated that the rate in developed countries was relative higher than in developing countries. Further trials with larger samples across more countries and more careful designed of experiments are required to confirm whether our findings are truly significant.

  18. Systematic Review of Interventions to Improve the Provision of Information for Adults with Primary Brain Tumors and Their Caregivers

    PubMed Central

    Langbecker, Danette; Janda, Monika

    2014-01-01

    Background: Adults with primary brain tumors and their caregivers have significant information needs. This review assessed the effect of interventions to improve information provision for adult primary brain tumor patients and/or their caregivers. Methods: We included randomized or non-randomized trials testing educational interventions that had outcomes of information provision, knowledge, understanding, recall, or satisfaction with the intervention, for adults diagnosed with primary brain tumors and/or their family or caregivers. PubMed, MEDLINE, EMBASE, and Cochrane Reviews databases were searched for studies published between 1980 and June 2014. Results: Two randomized controlled, 1 non-randomized controlled, and 10 single group pre–post trials enrolled more than 411 participants. Five group, four practice/process change, and four individual interventions assessed satisfaction (12 studies), knowledge (4 studies), and information provision (2 studies). Nine studies reported high rates of satisfaction. Three studies showed statistically significant improvements over time in knowledge and two showed greater information was provided to intervention than control group participants, although statistical testing was not performed. Discussion: The trials assessed intermediate outcomes such as satisfaction, and only 4/13 reported on knowledge improvements. Few trials had a randomized controlled design and risk of bias was either evident or could not be assessed in most domains. PMID:25667919

  19. Heart rate variability in children with type 1 diabetes mellitus

    PubMed Central

    Gardim, Camila Balsamo; de Oliveira, Bruno Affonso P.; Bernardo, Aline Fernanda B.; Gomes, Rayana Loch; Pacagnelli, Francis Lopes; Lorençoni, Roselene Modolo R.; Vanderlei, Luiz Carlos M.

    2014-01-01

    OBJECTIVE: To gather current information about the effects of type 1 diabetes mellitus on children's cardiac autonomic behavior. DATA SOURCES: The search of articles was conducted on PubMed, Ibecs, Medline, Cochrane, Lilacs, SciELO and PEDro databases using the MeSH terms: "autonomic nervous system", "diabetes mellitus", "child", "type 1 diabetes mellitus", "sympathetic nervous system" and "parasympathetic nervous system", and their respective versions in Portuguese (DeCS). Articles published from January 2003 to February 2013 that enrolled children with 9-12 years old with type 1 diabetes mellitus were included in the review. DATA SYNTHESIS: The electronic search resulted in four articles that approached the heart rate variability in children with type 1 diabetes mellitus, showing that, in general, these children present decreased global heart rate variability and vagal activity. The practice of physical activity promoted benefits for these individuals. CONCLUSIONS: Children with type 1 diabetes mellitus present changes on autonomic modulation, indicating the need for early attention to avoid future complications in this group. PMID:25119762

  20. Acupuncture for erectile dysfunction: a systematic review protocol

    PubMed Central

    Cui, Xiaoming; Li, Xiaoli; Peng, Weina; Zhou, Jing; Yu, Jinna; Ye, Yongming; Liu, Zhishun

    2015-01-01

    Introduction This systematic review protocol aims to provide a protocol for assessing the safety and effectiveness of acupuncture for the treatment of erectile dysfunction(ED). Previous systematic reviews did not draw convincing conclusions owing to high heterogeneity and few included randomised controlled trials, so it is necessary to reassess the efficacy and safety of acupuncture for ED. Methods and analysis Eight electronic databases will be searched: the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, PubMed, EMBASE, PsycInfo, the Chinese Biomedical Literature Database (CBM), the Chinese Medical Current Content (CMCC) and the China National Knowledge Infrastructure (CNKI). Related Chinese literature will be searched in other Chinese databases. All relevant randomised controlled trials in English or Chinese without any restrictions of publication type will be included. The main outcome measure will be improvements in sexual activity assessed by validated questionnaires. Assessment of risk of bias, data synthesis and subgroup analysis will be carried out using Review Manager 5.3. Ethics and dissemination The results of the systematic review will be disseminated via publication in a peer-reviewed journal and presented at a relevant conference. The data we will use do not include individual patient data, so ethical approval is not required. Trial registration number PROSPERO CRD42014013575. PMID:25805531